gebhart/patrepeval huggingface dataset:
Omnidirectional 3D Nanoplasmonic Optical Antenna Array via Soft-Matter Transformation (2011)

Inspired by the natural processes during morphogenesis, we demonstrate the transformation capability of active soft-matter to define nanoscale metal-on-polymer architectures below the resolution limit of conventional lithography. Specifically, using active polymers, we fabricate and characterize ultradense nanoplasmonic antenna arrays with sub-10 nm tip-to-tip nanogaps. In addition, the macroscale morphology can be independently manipulated into arbitrary three-dimensional geometries, demonstrated with the fabrication of an omnidirectional nanoplasmonic optical antenna array.
Studying Regioisomer Formation in the Pd‐Catalyzed Fluorination of Cyclic Vinyl Triflates: Evidence for in situ Ligand Modification** (2023)

Abstract Pd‐catalyzed nucleophilic fluorination reactions are important methods for the synthesis of fluoroarenes and fluoroalkenes. However, these reactions can generate a mixture of regioisomeric products that are often difficult to separate. While investigating the Pd‐catalyzed fluorination of cyclic vinyl triflates, we observed that the addition of a substoichiometric quantity of TESCF 3 significantly improved the regioselectivity of the reaction. Herein, we report a combined experimental and computational study on the mechanism of this transformation focusing on the role of TESCF 3 . The poor regioselectivity of the reaction in the absence of additives results from the formation of LPd‐cyclohexyne complexes (L=biaryl monophosphine ligand). When TESCF 3 is added to the reaction mixture, the generation of the Pd‐cyclohexyne complexes is diminished by an unexpected pathway involving the dearomatization of the ligand by nucleophilic attack from a trifluoromethyl anion (CF 3 − ).
Antibodies Against the Erythroferrone N-Terminal Domain Prevent Hepcidin Suppression and Ameliorate Murine Thalassemia (2019)

Erythroferrone (Erfe) is produced by erythroblasts in response to erythropoietin (EPO) and acts in the liver to prevent hepcidin stimulation by BMP6. Hepcidin suppression allows for the mobilization of iron to the bone marrow for the production of red blood cells. Aberrantly high circulating Erfe levels in conditions of stress erythropoiesis, such as in patients with β-thalassemia, promote the tissue iron accumulation that decisively contributes to morbidity in these patients. Here we developed neutralizing antibodies against Erfe to prevent hepcidin suppression and correct the iron loading phenotype in a mouse model of β-thalassemia (Hbb Th3/+ mice) and used these antibodies as tools to further characterize Erfe's mechanism of action. We demonstrate that Erfe binds to BMP6 with low nanomolar affinity, but also binds BMP2 and BMP4 with lower affinities. We further show that BMP6 binds the N-terminal domain of ERFE. This domain in itself was sufficient to cause hepcidin suppression in Huh7 hepatoma cells and in vivo in wildtype mice. Concurrently, anti-Erfe antibodies targeting the N-terminal domain prevented hepcidin suppression in Erfe-treated Huh7 cells and in EPO-treated mice. Crystal structure of the antibodies in contact with an N-terminal peptide of Erfe demonstrated critical contacts in the Erfe N-terminal domain imparting antibody selectivity to human and murine protein. Finally, we tested these antibodies in vivo in a mouse model of thalassemia. We observed a decrease in serum and liver iron in antibody-treated Hbb Th3/+ mice. In addition, treatment with anti-Erfe antibodies increased the number of red blood cells, hemoglobin concentration and hematocrit, while decreasing the number of reticulocytes and the red cell distribution width. These changes were more pronounced when mice are treated for eight weeks. Anti-Erfe treatment caused an increase in hepatic hepcidin mRNA expression, red blood cells, hemoglobin and hematocrit, while reticulocytes levels were lower and peripheral red cell lifespan was increased. In summary, we demonstrate that antibodies targeting the N-terminal domain of Erfe constitute a potential therapeutic tool for iron-loading anemias. Disclosures Arezes: UCB: Employment. Foy:Pfizer Inc.: Employment. Benard:pfizer: Employment. Sawant:Pfizer Inc.: Employment. Tam:Pfizer Inc.: Employment. Maben:Pfizer Inc.: Employment. LaVallie:Pfizer Inc.: Employment. Cunningham:Pfizer Inc.: Employment. Lambert:Pfizer Inc.: Employment. Pittman:Pfizer Inc.: Employment. Murphy:Pfizer Inc.: Employment. Draper:Pfizer: Research Funding. Jasuja:Pfizer Inc.: Employment. Drakesmith:Pfizer: Consultancy, Research Funding; Kymab: Other: Scientific Advistory; La Jolla Pharmaceutical: Research Funding.
LB-S&amp;T-14 MICRO-RNA 144 ENHANCES GLUCOCORTICOID RECEPTOR BETA DURING BLADDER CANCER INVASION (2016)

prostate disease (BPD) between subjects with and without H. pylori infection. In animal study, subcutaneous dorsal H. pylori protein extract injection in time sequential manner was used to induce chronic reaction. Systemic and prostate inflammation were evaluated by checking splenic tumor necrosis factor alpha (TNF-a), interleukin-1 beta (IL-1b), and prostatic nuclear factor-kappa B (NF-kB) respectively. Prostate was stained to confirm the location of these responses.
RETRACTED ARTICLE: The urinary exosomes derived from premature infants attenuate cisplatin-induced acute kidney injury in mice via microRNA-30a-5p/ mitogen-activated protein kinase 8 (MAPK8) (2022)

Acute kidney injury (AKI) is a susceptible factor for chronic kidney disease (CKD). There is still a lack of effective prevention methods in clinical practice. This study investigated the protective effect of the urinary exosomes from premature infants on cisplatin-induced acute kidney injury. Here we isolated exosomes from the fresh urine of premature infants. A C57BL/6 mice model of cisplatin-induced acute kidney injury was given 100 ug urinary exosomes 24 hours after model establishment. The kidneys were collected for pathological examination and the evaluation of renal tubular damage and apoptosis. In the <i>in vitro</i> experiment, human renal cortex/proximal tubular cells (HK-2) were induced by cisplatin to assess the effect of the urine exosomes from premature infants. Exosome microRNA (miRNA) sequencing technology was applied to investigate the miRNAs enriched in exosomes and the dual-luciferase gene reporter system to examine the targeting relationship of the miRNA with target genes. The results indicated that the urinary exosomes could decrease the serum creatinine level and the apoptosis of renal tubular cells, and reduce mice mortality. In addition, miR-30a-5p was the most abundant miRNA in the exosomes. It protected HK-2 cells from cisplatin-induced apoptosis by targeting and down-regulating the mitogen-activated protein kinase 8 (MAPK8). Together, our findings identified that the urinary exosomes derived from premature infants alleviated cisplatin-induced acute kidney injury and inhibited the apoptosis of HK-2 via miR-30a-5p, which could target MAPK8. These findings implied that urinary exosomes from premature infants riched in miR-30a-5p might become a potential treatment for AKI.
Distinguishing post‐translational modifications in dominantly inherited frontotemporal dementias: FTLD‐TDP Type A ( <i>GRN</i> ) vs Type B ( <i>C9orf72</i> ) (2022)

The current results provide evidence that the intraneuronal inclusions in the two genetic diseases contain TDP-43 filaments. The discovery of novel, potentially type-specific TDP-43 PTMs emphasises the need to determine the mechanisms leading to filament formation and PTMs, and the necessity of exploring the validity and occupancy of PTMs in a prognostic/diagnostic setting.
Ibrutinib and idelalisib target B cell receptor- but not CXCL12/CXCR4-controlled integrin-mediated adhesion in Waldenstrom macroglobulinemia (2015)

The Bruton tyrosine kinase (BTK) inhibitor ibrutinib and the phosphatidylinositol 3-kinase δ (PI3Kδ) inhibitor idelalisib show promising clinical efficacy in the treatment of Waldenstrom macroglobulinemia (WM), a lymphoplasmacytic lymphoma.[1][1]–[3][2] Very recently, ibrutinib became the first
Cyclic and Lasso Peptides: Sequence Determination, Topology Analysis, and Rotaxane Formation (2018)

A broadly applicable chemical cleavage methodology to facilitate MS/MS sequencing was developed for macrocyclic and lasso peptides, which hold promise as exciting new therapeutics. Existing methods such as Edman degradation, CNBr cleavage, and enzymatic digestion are either limited in scope or completely fail in cleavage of constrained nonribosomal peptides. Importantly, the new method was utilized for synthesizing a unique peptide-based rotaxane (both cyclic and threaded) from the lasso peptide, benenodin-1 ΔC5.
The effects of Pertussis toxin on Group 1 Metabotropic Glutamate Receptors Expressed in a Syrian Hamster Tumour Cell Line (1999)

Conference Abstract| June 01 1999 The effects of Pertussis toxin on Group 1 Metabotropic Glutamate Receptors Expressed in a Syrian Hamster Tumour Cell Line Non Evans; Non Evans 1Eli Lilly & Co. Ltd., Lilly Research centre, Erl Wood Manor, Windlesham, Surrey GU20 6PH Search for other works by this author on: This Site PubMed Google Scholar Ann Kingston Ann Kingston 1Eli Lilly & Co. Ltd., Lilly Research centre, Erl Wood Manor, Windlesham, Surrey GU20 6PH Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1999) 27 (3): A116. https://doi.org/10.1042/bst027a116b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Non Evans, Ann Kingston; The effects of Pertussis toxin on Group 1 Metabotropic Glutamate Receptors Expressed in a Syrian Hamster Tumour Cell Line. Biochem Soc Trans 1 June 1999; 27 (3): A116. doi: https://doi.org/10.1042/bst027a116b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1999 Biochemical Society1999 Article PDF first page preview Close Modal You do not currently have access to this content.
Effects of Scattering Direction of Hot Electrons in the Drain of Ballistic n<sup>+</sup>–i–n<sup>+</sup> Diode (2011)

Ionized impurity scattering has a weak influence on hot electron transport at low doping concentrations owing to the fact that ionized impurity scattering is an anisotropic scattering with a high preference for forward scattering and most hot electrons are absorbed in the drain after undergoing ionized impurity scattering. On the other hand, ionized impurity scattering approaches isotropic characteristics at sufficiently high doping concentrations and enhances the scattering of hot electrons in the backward direction and severely degrades the peak of the mean velocity of electrons in the channel and the steady-state current. We conclude that the scattering direction is an important factor for hot electron transport in the drain region of semiconductor devices.
Limits of specific contact resistivity to Si, Ge and III-V semiconductors using interfacial layers (2013)

Specific contact resistivities of source/drain contacts employing interfacial layers are calculated with simulations of tunneling transport. Fermi level depinning, dipoles, and other techniques for barrier lowering are explored. Interfacial materials with the potential to meet future contact resistivity requirements are identified for silicon and high-mobility alternatives.
« Des amis, des témoins, des possibilités de jeu » (2011)

Le Chemin Solitaire d’Arthur Schnitzler joué par le Tg STAN, c’est d’abord la virtuosité incroyable des acteurs du collectif qui incarnent chacun à tour de rôle plusieurs personnages. Mais pour la question qui nous intéresse, c’est aussi, au niveau scénographique, un plateau blanc quadrillé d’objets divers allant du plus quotidien (un grille-pain, une bouilloire électrique, une machine à café), au plus insolite (un bain de pied, un broyeur à bois). C’est autour de cette présence et des foncti...
An error-aware gaze-based keyboard by means of a hybrid BCI system (2018)

Gaze-based keyboards offer a flexible way for human-computer interaction in both disabled and able-bodied people. Besides their convenience, they still lead to error-prone human-computer interaction. Eye tracking devices may misinterpret user's gaze resulting in typesetting errors, especially when operated in fast mode. As a potential remedy, we present a novel error detection system that aggregates the decision from two distinct subsystems, each one dealing with disparate data streams. The first subsystem operates on gaze-related measurements and exploits the eye-transition pattern to flag a typo. The second, is a brain-computer interface that utilizes a neural response, known as Error-Related Potentials (ErrPs), which is inherently generated whenever the subject observes an erroneous action. Based on the experimental data gathered from 10 participants under a spontaneous typesetting scenario, we first demonstrate that ErrP-based Brain Computer Interfaces can be indeed useful in the context of gaze-based typesetting, despite the putative contamination of EEG activity from the eye-movement artefact. Then, we show that the performance of this subsystem can be further improved by considering also the error detection from the gaze-related subsystem. Finally, the proposed bimodal error detection system is shown to significantly reduce the typesetting time in a gaze-based keyboard.
Three new carbazole alkaloids from Murraya euchrestifolia. (1987)

The structures of a monomeric carbazole, isomurrayafoline-B (1), and two new dimeric carbazoles, bismurrayafolinol (3) and oxydimurrayafoline (9), from Murraya euchrestifolia Hayata (Rutaceae) have been studied in spectral and chemical experiments.
Synthesis and Electronic Properties of Low-Dimensional Bis(benzene) Vanadium Reduced Mesoporous Niobium Oxide Composites (2001)

The first bis(benzene) vanadium mesoporous niobium oxide composite was synthesized and characterized. The XRD pattern of this material shows a peak (100) centered at 45 A, identical to that of starting material. The nitrogen adsorption and desorption analyses of this material exhibit a slight decrease of BET surface area from 580 m(2) g(-1) to 467 m(2) g(-1) and a concomitant decrease in pore size and volume from 28 A and 0.500 cm(3) g(-1) to 25 A and 0.363 cm(3) g(-1), respectively. The powder EPR spectrum shows eight lines which can be assigned to (51)V from bis(benzene) vanadium as well as other resonances that can be assigned to the corresponding cation. The presence of two or more organometallic vanadium species was further confirmed by UV, (1)H-MAS NMR, and XPS methods. Broadened and shifted Nb 3/2, 5/2 peaks were also observed, providing further evidence that the mesoporous transition metal oxide framework was reduced by the organometallic. SQUID magnetometer measurements on this material show paramagnetic behavior with a small contribution of spin glass behavior. The conductivity of this material was 10(-4) ohm(-1) cm(-1), significantly greater than that measured for the analogous bis(benzene) chromium composite previously studied. Since alkali-metal reduced mesoporous niobium oxide materials are insulating, this conductivity was attributed to the low-dimensional bis-arene vanadium phase in the pores and rationalized according to the balance between the Hubbard potential and the bandwidth estimated for the relevant organometallic species. A bis-1,3,5-tri-tert-butylbenzene yttrium composite was also synthesized; however, complete loss of ligand upon reduction of the mesostructure was observed, indicating that this dopant behaves more like an alkali naphthalene reagent in its reactions with mesoporous niobium oxide than other bis(arene) complexes investigated by our group.
On Dynamic Pricing with Covariates (2021)

We consider dynamic pricing with covariates under a generalized linear demand model: a seller can dynamically adjust the price of a product over a horizon of $T$ time periods, and at each time period $t$, the demand of the product is jointly determined by the price and an observable covariate vector $x_t\in\mathbb{R}^d$ through a generalized linear model with unknown co-efficients. Most of the existing literature assumes the covariate vectors $x_t$'s are independently and identically distributed (i.i.d.); the few papers that relax this assumption either sacrifice model generality or yield sub-optimal regret bounds. In this paper, we show that UCB and Thompson sampling-based pricing algorithms can achieve an $O(d\sqrt{T}\log T)$ regret upper bound without assuming any statistical structure on the covariates $x_t$. Our upper bound on the regret matches the lower bound up to logarithmic factors. We thus show that (i) the i.i.d. assumption is not necessary for obtaining low regret, and (ii) the regret bound can be independent of the (inverse) minimum eigenvalue of the covariance matrix of the $x_t$'s, a quantity present in previous bounds. Moreover, we consider a constrained setting of the dynamic pricing problem where there is a limited and unreplenishable inventory and we develop theoretical results that relate the best achievable algorithm performance to a variation measure with respect to the temporal distribution shift of the covariates. We also discuss conditions under which a better regret is achievable and demonstrate the proposed algorithms' performance with numerical experiments.
Beyond the cybernetic jam fantasy: the continuator (2004)

The Continuator is a usable musical instrument combining techniques from interactive and automatic learning systems. It learns and interactively plays with a user in the user's style. Music-generation systems have traditionally belonged to one of two categories: interactive systems in which players trigger musical phrases, events, or effects, such as the Karma musical workstation, and systems such as Risset's interactive piano, which allow for user input such as keystrokes or chords, but can't learn and use preprogrammed musical styles. Most of these systems propose musical effects libraries (a term used in the Karma workstation meaning a generation of music material based on user input). Although some of these effects are musically impressive, these systems can't be considered cybernetic musicians or even musical companions, because they use preprogrammed reactions and have no memory or facility for evolving.
Proposal of integrated search engine of web and TV contents (2006)

A search engine that can handle TV programs and Web content in an integrated way is proposed. Conventional search engines have been able to handle Web content and/or data stored in a PC desktop as target information. In the future, however, the target information is expected to be stored in various places such as in hard-disk (HD)/DVD recorders, digital cameras, mobile devices, and even in real space as ubiquitous content, and a search engine that can search across such heterogeneous resources will become essential. Therefore, as a first step towards developing such next-generation search engine, a prototype search system for Web and TV programs is developed that performs integrated search of those content, and that allows chain search where related content can be accessed from each search result. The integrated search is achieved by generating integrated indices for Web and TV content based on vector space model and by computing similarity between the query and all the content described by the indices. The chain search of related content is done by computing similarity between the selected result and all other content based on the integrated indices. Also, the zoom-based display of the search results enables to control media transition and level of details of the contents to acquire information efficiently. In this paper, testing of a prototype of the integrated search engine validated the approach taken by the proposed method.
Supplementary Figures 1 - 6 from Inhibiting Tankyrases Sensitizes KRAS-Mutant Cancer Cells to MEK Inhibitors via FGFR2 Feedback Signaling (2023)

&lt;p&gt;PDF file - 660KB, Supplementary Figure S1. All RAS mutant cell lines have a higher sensitivity to the TNKSi/MEKi combination. Supplementary Figure S2. Validation of TNKSi/MEKi combination in KRAS mutant cancer cells. Supplementary Figure S3. Combinations with MEK inhibitor in the SW480 cell line. Supplementary Figure S4. TNKSi/MEKi combination leads to enhanced inhibition of AKT signaling activity. Supplementary Figure S5. TNKSi potentiates MEKi by releasing a feedback loop on FGFR2 signaling. Supplementary Figure S6. Consequences of combined inhibition of TNKS and MEK on FGFR2 and AKT signaling pathways in KRAS mutant cell lines.&lt;/p&gt;
Applications of Pillar[<i>n</i>]arene‐Based Supramolecular Assemblies (2018)

Macrocycles are an important player in supramolecular chemistry. In 2008, a new class of macrocycles, "pillar[n]arenes", were first discovered. Research efforts in the area of pillar[n]arenes have elucidated key properties, such as their shape, reaction mechanism, host-guest properties, and their versatile functionality, which has contributed to the development of pillar[n]arene chemistry and their applications to various fields. This Minireview describes how pillar[n]arene-based supramolecular assemblies can be applied to supramolecular gel formation, reactions, light-harvesting systems, drug-delivery systems, biochemical applications, separation and storage materials, and surface chemistry.
Risk for subsequent venous thromboembolic complications in carriers of the prothrombin or the factor V gene mutation with a first episode of deep-vein thrombosis (2000)

Abstract Carriers of a mutation in the prothrombin (clotting factor II) or factor V gene have a 2- to 4-fold greater risk for venous thromboembolism than subjects without the mutations. Whether both mutations also predispose to recurrent venous thromboembolism is unclear. Outpatients who had a first episode of proven symptomatic deep-vein thrombosis and a long-term follow-up were studied. The outcome measure was the cumulative incidence of confirmed venous thromboembolic complications. Two hundred fifty-one patients were enrolled in the study. Mean duration of follow-up was 8.3 years. The prothrombin gene mutation was demonstrated in 27 patients (prevalence, 10.8%; 95% CI, 6.9 to 14.6), and the factor V gene mutation was demonstrated in 41 patients (prevalence, 16.3%; 95% CI, 11.8 to 20.9). The cumulative incidence of venous thromboembolic complications after 10 years was 61.3% (95% CI, 35.7 to 87.9), and the hazard ratio was 2.4 (95% CI, 1.3 to 4.7; P = .004) in patients with the prothrombin gene mutation); the cumulative incidence of venous thromboembolic complications after 10 years was 55.2% (95% CI, 36.4 to 74.0), and the hazard ratio was 2.4 (95% CI, 1.4 to 4.1;P = .001) in patients with the factor V gene mutation. In comparison, the cumulative incidence of venous thromboembolic complications after 10 years was 23.1% (95% CI, 16.2 to 30.1) in patients without the mutations. Prothrombin and factor V gene mutations occur frequently in patients with venous thrombosis and are associated with an increased risk for recurrent venous thromboembolic complications
Demonstration of passive <i>Q</i> -switching inmultiquantum well InGaAs/AlGaInAs diode laser (2000)

The first passive Q-switched operation is reported of an InGaAs/AlGaInAs diode laser with a frequency repetition ranging from 1 to 2.5 GHz at the emitting wavelength of 1.58 µm. This material is important as a thermally stable alternative to InGaAsP based laser systems operating around 1.5 µm.