gebhart/patrepeval huggingface dataset:
Mechanism of Date Retention Improvement by High Temperature Annealing of Al<sub>2</sub>O<sub>3</sub> Blocking Layer in Flash Memory Device (2011)

The mechanism underlying improved data retention via high-temperature oxygen annealing of the Al 2 O 3 blocking layer in a charge-trap type flash memory device is investigated in comparison with the case of high-temperature nitrogen annealing. The results show that significant improvement of the retention property can be achieved by oxygen annealing at 1100 °C, compared to nitrogen annealing. Experimental evidence indicated that the underlying mechanism does not arise from suppression of the trap-assisted tunneling current through the blocking oxide; instead it is caused by a reduction of the thermionic emission component of the charge loss factor. This is possibly due to changes of the conduction band offset of the crystallized Al 2 O 3 .
Clinical activity, safety and tolerability of ASN002, a dual SYK/JAK inhibitor, in patients non-Hodgkin lymphoma (NHL) and solid tumors. (2017)

7545 Background: ASN002 is a novel, potent inhibitor of Spleen Tyrosine Kinase (SYK) and Janus Kinases (JAK). Pre-clinical studies indicate that ASN002 has low nM IC50s against SYK and JAK, decreases proliferation in ibrutinib-resistant cell lines, and suppresses tumor growth in rodent xenograft models of NHL and other hematologic malignancies. Methods: This Phase 1/2 clinical trial in patients with solid tumors and hematologic malignancies evaluates escalating ASN002 oral doses of 10, 20, 30, 40, 50 and’ 75 mg BID and 80 and 120 mg QD mg (NCT02440685). Phase 1 allows patients with solid tumors or hematologic malignancies; Phase 2 allows only patients with diffuse large B-Cell lymphoma (DLBCL), follicular lymphoma (FL) or mantle cell lymphoma (MCL). Endpoints include safety, tolerability, pharmacokinetics, serum markers of inflammation, and response using RECIST or Lugano Classification System. Results: Twenty-eight patients have enrolled in the DLT phase at doses of 10 mg – 75 mg BID and at 80 mg QD. All patients had multiple prior lines of treatment (range: 2 – 8). ASN002 was well tolerated. No dose limiting adverse events have been reported at these dose levels. Most drug-related adverse events were Gr 1/2 (e.g. headache, fatigue). Steady-state systemic exposure was high (C max , AUC (0-12h) and T 1/2 at 40 mg BID were 0.7 µM, 6.3 µM.h and 18 h, respectively). High systemic exposure was also observed at 80 mg QD. Robust reduction of CRP, IL-18, MIP1β, VCAM-1, TNFR2 was observed at all doses. Stable disease (RECIST, 9+ months) in a patient with primary peritoneal cancer, about 50% reduction in target lesions at 3 months in a FL patient (Lugano, 6 prior lines) and stable disease and reduction of pruritus in a peripheral T-Cell lymphoma patient after 2 months (Lugano, 2 prior lines) of treatment were observed. ASN002 treatment continues in both lymphoma patients. Accrual of patients continues. Conclusions: ASN002 was safe and well tolerated. Encouraging preliminary evidence of efficacy in NHL patients was observed. MTD has not been reached and dose escalation continues. Updated and detailed results will be presented. Clinical trial information: NCT02440685.
<i>In Vitro</i> Degradation of a Poly(Propylene Fumarate)/ <i>β</i> -Tricalcium Phosphate Composite Orthopaedic Scaffold (1997)

This study involves investigating the in vitro degradation of a poly(propylene fumarate) (PPF) based composite material for orthopaedic applications. The effects of PPF molecular weight, PPF to vinyl monomer ratio, and solid phase content were studied. Mechanical properties, pore morphology, and sample mass loss were analyzed over a 12-week period of degradation. An initial increase in both compressive modulus and strength was seen for all formulations incorporating high molecular weight PPF. The PPF/monomer ratio was not seen to have a significant effect on any observations. Incorporation of β-tricalcium phosphate (β-TCP) resulted in an increase in mechanical properties and had no effect on weight loss. A composite formulation with an initial PPF/β-TCP ratio of 1.0 g/0.66 g exhibited an initial compressive strength of 2.60 MPa, which rose to 9.38 MPa at 3 weeks, and fell to 3.24 MPa at 7 weeks into the study. The initial modulus of 62.0 MPa for the same formulation increased to 250 MPa at 3 weeks, and fell to 63.7 MPa at 7 weeks. These studies further show that PPF/β-TCP composite scaffolds can be fabricated exhibiting initial mechanical properties similar to human trabecular bone and maintain these properties over several weeks of degradation.
Immobilization Techniques and Integrated Signal Enhancement for POC Nanocolor Microfluidic Devices (2015)

Resonance enhanced absorption (REA) nanocolor microfluidic devices are new promising bioassay platforms, which employ nanoparticle‐ (NP‐) protein conjugates for the immunodetection of medically relevant markers in biologic samples such as blood, urine, and saliva. The core component of a REA test device is a PET chip coated with aluminum and SiO 2 thin layers, onto which biorecognitive molecules are immobilized. Upon addition of a sample containing the analyte of interest, a NP‐protein‐analyte complex is formed in the test device that is captured on the REA chip, for example, via streptavidin‐biotin interaction. Thereby, a colored symbol is generated, which allows optical readout. Silver enhancement of the bound nanoparticles may be used to increase the sensitivity of the assay. Herein, we demonstrate that adsorptive immobilization via a cationic polymeric interlayer is a competitive and fast technique for the binding of the capture protein streptavidin onto planar SiO 2 surfaces such as REA biochips. Moreover, we report the development of a silver enhancement technology that operates even in the presence of high chloride concentrations as may be encountered in biologic samples. The silver enhancement reagents may be integrated into the microfluidic assay platform to be released upon sample addition. Hereby, a highly sensitive one‐step assay can be realized.
Virulence genes in herpes simplex virus type 1 corneal infection (2004)

Click to increase image sizeClick to decrease image sizecorneal infection herpes simplex virus keratitis virulence virulence genes
FREQUENCY-TUNABLE BANDPASS FILTERS WITH CONSTANT ABSOLUTE BANDWIDTH AND IMPROVED LINEARITY (2012)

This paper presents a frequency-tunable bandpass fllter with constant absolute bandwidth and improved linearity. The proposed resonator is composed of an open-ended transmission line with back-to-back varactor diodes loaded at one end. The back-to-back varactor diodes are used to enhance the linearity of the fllter, which is better than that of the single varactor counterparts. A mixed electric and magnetic coupling scheme is utilized to control the overall coupling coe-cients so that the absolute bandwidth can be kept constant when the frequency is tuned. For validation, two frequency-tuning fllters with 30-MHz and 44-MHz absolute bandwidth are implemented. The experimental and simulated results are presented to verify the proposed design.
Bayesian Markov chain Monte Carlo imputation for the transiting exoplanets with an application in clustering analysis (2015)

To impute the missing values of mass in the transiting exoplanet data, this paper uses the Frank copula to combine two Pareto marginal distributions. Next, a Bayesian Markov chain Monte Carlo (MCMC) imputation method is proposed. The proposed Bayesian MCMC imputation method is found to outperform the mean imputation method. Clustering analysis can shed light on the formation and evolution of exoplanets. After imputing the missing values of mass in the transiting exoplanet data using the proposed approach, the similarity-based clustering method (SCM) clustering algorithm is applied to the logarithm of mass and period for this complete data set. The SCM clustering result indicates two clusters. Furthermore, the intracluster Spearman rank-order correlation coefficients ρs for mass and period in these two clusters are 0.401 and −0.188, respectively, at a significance level of 0.01. This result illustrates that the mass and period correlate in an opposite way between the two different clusters. It implies that the formation and evolution processes of these two clusters are different.
Single-Event Upsets in Substrate-Etched CMOS SOI SRAMs Using Ultraviolet Optical Pulses with Sub-Micrometer Spot Sizes (2013)

International audience
Ultra high-speed fiber wireless transport (2014)

This paper describes high-speed data transmission based on combination of optical fiber and radio-wave links, which would enable low-latency transfer and agile deployment capability, where broadband radio signal waveforms can be transferred by radio-on-fiber technology.
Mechanism of the<i>ortho-para</i>conversion of hydrogen on Ag surfaces (2008)

Ortho-para conversion of ${\mathrm{H}}_{2}$ and para-ortho conversion of ${\mathrm{D}}_{2}$ on an Ag surface were investigated by resonance-enhanced multiphoton ionization combined with photostimulated desorption. The conversion processes were found to be accelerated by laser irradiation at $193\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$, while photo-irradiation at $532\phantom{\rule{0.3em}{0ex}}\mathrm{nm}$ had little effect on the conversion time. The natural conversion time of ${\mathrm{H}}_{2}$ and ${\mathrm{D}}_{2}$ was estimated to be 610 and $1030\phantom{\rule{0.3em}{0ex}}\mathrm{s}$, respectively. The roles of electron transfer and rotational-energy dissipation in the conversion are discussed.
Regulation of the<i>Bacillus subtilis yciC</i>Gene and Insights into the DNA-Binding Specificity of the Zinc-Sensing Metalloregulator Zur (2008)

The Bacillus subtilis Zur protein regulates zinc homeostasis by repressing at least 10 genes in response to zinc sufficiency. One of these genes, yciC, encodes an abundant protein postulated to function as a metallochaperone. Here, we used a genetic approach to identify the cis-acting elements and trans-acting factors contributing to the tight repression of yciC. Initial studies led to the identification of only trans-acting mutations, and, when the selection was repeated using a transposon library, all recovered mutants contained insertionally inactivated zur. Using a zur merodiploid strain, we obtained two cis-acting mutations that contained large deletions in the yciC regulatory region. We demonstrate that the yciC regulatory region contains two functional Zur boxes: a primary site (C2) overlapping a sigma(A) promoter approximately 200 bp upstream of yciC and a second site near the translational start point (C1). Zur binds to both of these sites to mediate strong, zinc-dependent repression of yciC. Deletion studies indicate that either Zur box is sufficient for repression, although repression by Zur bound to C2 is more efficient. Binding studies demonstrate that both sites bind Zur with high affinity. Sequence alignment of these and previously described Zur boxes suggest that Zur recognizes a more extended operator than other Fur family members. We used synthetic oligonucleotides to identify bases critical for DNA binding by Zur. Unlike Fur and PerR, which bind efficiently to sequences containing a core 7-1-7 repeat element, Zur requires a 9-1-9 inverted repeat for high-affinity binding.
Femtosecond pulse generation with a diode-pumped Yb^3+:YVO_4 laser (2005)

A diode-pumped Yb:YVO4 laser has been passively mode locked for the first time, to our knowledge. 120 fs pulses with an average output power of 300 mW and a peak power as high as 14.5 kW are obtained by use of a semiconductor saturable-absorber mirror for passive mode locking. The optical spectrum has a 10 nm bandwidth (full width at half-maximum) and is centered at 1021 nm.
In Situ FTIR‐Diffuse Reflection Spectroscopy of the Anode Surface in a Direct Methanol/Oxygen Fuel Cell (1996)

In situ Fourier transform infrared‐diffuse reflection spectroscopy is introduced as a method for studying the catalytic surfaces of membrane electrode assemblies in working fuel cells. An annular collection electrode and a window are used to expose a sufficient area of the electrode to the IR beam. Experimental results for methanol oxidation, CO adsorption, and adsorption show that this method can be used to monitor the catalyst surface in a direct methanol fuel cell under load. The IR peaks associated with CO adsorption on high surface area Pt‐Ru are similar to previously observed peaks on smooth electrodes reported in the literature.
A Multi-Dimensional Approach to Improving Skin Barrier Function, Reducing Skin Sensitivity and Cosmetic Intolerance Syndrome (2009)

Skin sensitivity can arise from impaired barrier function or an exaggerated response to topically applied agents which normally are minimally irritating. As we age, skin sensitivity generally increases. This is in part due to a decrease in the production of key barrier lipids, thus allowing for an increased penetration into the skin. Skin reactivity also often changes, due to the over expression or under expression of key genes involved in regulation of the inflammatory response. Together these changes are responsible for an increase in what has been recently termed “Cosmetic Intolerance Syndrome” (CIS). CIS is an idiopathic response to the use or overuse of multiple cosmetic products. CIS reactions range from simple stinging and burning to an all out allergic contact dermatitis.
Device-free passive localization from signal subspace eigenvectors (2014)

Device-free passive (DFP) localization systems are a key solution for location-based services because they do not require any wireless device on a human body. Most of the existing DFP localization systems are based on the received signal strength (RSS) measurement only. However, the localization accuracy of RSS only-based systems is easily affected by the spatial and temporal variances of RSS due to multipath fading and noise, even in a static environment. In this paper, we propose a novel localization system for DFP using signal subspace eigenvectors from an antenna array. We present a fingerprinting technique using multiclass support vector machines (SVMs) based on a combination of array signal features with spatial and temporal averaging. We then evaluate the localization accuracy of our proposed system in different propagation environments: line-of-sight (LOS) and non-line-of-sight (NLOS). In addition, we analyze two types of receive antenna placement: centralized and distributed antennas. The experimental results show that the localization accuracy can be improved by the proposed system, particularly in the centralized antenna case. Moreover, they show that the proposed system can improve localization accuracy compared to the conventional RSS-only based system.
A Comparative Analysis of Iridium Oxide Nanowires in Electrical Detection of Biochemical Reactions (2008)

Pt, Ir, Au and few other precious metals have highly conducive electrical and chemical properties; hence have been widely used in pH sensors and bimolecular sensing applications. The chief objective of this research is to highlight and demonstrate the advantages that Iridium Oxide (IrOx) nanowires offer over these competing metals in improving the performance metrics of biomolecular sensing. Iridium oxide has very good conductivity and very high charge storing capacity, and hence has an ability to detect very small changes in the surface charge. Nanowires have an ideal morphology to crowd protein molecules and highly increase the surface area of interaction. Higher area of interaction along with iridium oxide's high intrinsic physical adsorption rate, strongly enhance the rate of immobilization of biomolecules and hence enabling high sensitivity detection. Inflammatory protein, C-Reactive protein (CRP) that is a biomarker for cardiovascular disease was used as the model biomolecule for this study.
Low rifampicin concentrations in tuberculosis patients with HIV infection (2014)

Approximated peak rifampicin concentrations were well below the recommended target range of 8 to 24 µg/mL in this patient population with its high frequency of the SLCO1B1 (rs4149032) polymorphism. Increased rifampicin dosage may be warranted in African, HIV- TB co-infected patients.
Removal of geosmin and 2-methylisoborneol during managed aquifer recharge: batch and column studies (2012)

Managed aquifer recharge is a robust barrier in the multi-barrier approach to supply safe drinking water. The removal performance of gesomin and 2-methylisoborneol through managed aquifer recharge was investigated using batch and column experiments. Batch experiments were carried out to investigate the removal of geosmin and 2-methylisoborneol (MIB) in the presence of different types of biodegradable organic matter using different types of water. Five different types of water spiked with 70-293 ng/L of geosmin and MIB were used in batch reactors, and complete removal of geosmin and MIB (down to the detection limit) was achieved in all cases. Soil column studies showed that biodegradation contributed to the removal of geosmin and MIB by 23 and 31%, respectively (empty bed contact time: 17 hours). The removal of geosmin and MIB appeared to be influenced more by microbial activity than the initial concentrations of geosmin and MIB. Adsorption was found to be the dominant mechanism (major role) followed by biodegradation (minor role) for geosmin and MIB removals during soil passage. Managed aquifer charge can therefore be used as a robust barrier to remove taste and odor (T&amp;O) causing compounds.© IWA Publishing 2012.
Abstract PR08: Autophagic degradation of Δ133p53 during replicative cellular senescence: An isoform-specific protein degradation mechanism for p53 (2013)

Abstract Δ133p53, a p53 isoform that dominant-negatively inhibits full-length p53, is downregulated at replicative senescence in a manner independent of mRNA regulation and proteasome-mediated degradation. We here demonstrate that, in contrast to proteasomal degradation of full-length p53, Δ133p53 is degraded by autophagy. Pharmacological inhibition of autophagy restores the reduced expression of Δ133p53 in replicatively senescent fibroblasts. The siRNA-mediated knockdown of pro-autophagic proteins (ATG5, ATG7 and Beclin-1) also results in restored expression of Δ133p53. The degradation of Δ133p53 via selective autophagy is indicated by its ubiquitination at the C-terminal lysine residues, its colocalization in the cytoplasm with a ubiquitin-binding protein p62/SQSTM1 and an autophagosome component LC3-II upon autophagy induction, and its stabilization by siRNA knockdown of p62/SQSTM1. A chaperone-associated E3 ubiquitin ligase STUB1, rather than MDM2, physically interacts with Δ133p53 and, consistent with the downregulation of endogenous STUB1 at replicative senescence, siRNA knockdown of STUB1 induces autophagic degradation of Δ133p53 and thereby senescence. Our data reveal that Δ133p53 degradation is controlled specifically by STUB1, rather than overall activity of autophagy. This study has identified for the first time a p53 isoform-specific protein turnover mechanism that orchestrates p53-mediated senescence and supports the hypothesis that Δ133p53 functions at the crossroads of senescence and autophagy. This abstract is also presented as poster B19. Citation Format: Izumi Horikawa, Kaori Fujita, Lisa Miller Jenkins, Yukiharu Hiyoshi, Abdul M. Mondal, Borivoj Vojtesek, David P. Lane, Ettore Appella, Curtis C. Harris. Autophagic degradation of Δ133p53 during replicative cellular senescence: An isoform-specific protein degradation mechanism for p53. [abstract]. In: Proceedings of the Third AACR International Conference on Frontiers in Basic Cancer Research; Sep 18-22, 2013; National Harbor, MD. Philadelphia (PA): AACR; Cancer Res 2013;73(19 Suppl):Abstract nr PR08.
Fast Computation of Combustion Phasing and Its Influence on Classifying Random or Deterministic Patterns (2016)

The classification between a sequence of highly variable combustion events that have an underlying deterministic pattern and a sequence of combustion events with similar level of variability but random characteristics is important for control of combustion phasing. In the case of high cyclic variation (CV) with underlying deterministic patterns, it is possible to apply closed-loop combustion control on a cyclic-basis with a fixed mean value, such as injection timing in homogeneous charge compression ignition (HCCI) or spark timing in spark ignition (SI) applications, to contract the CV. In the case of a random distribution, the high CV can be avoided by shifting operating conditions away from the unstable region via advancing or retarding the injection timing or the spark timing in the mean-sense. Therefore, the focus of this paper is on the various methods of computing CA50 for analyzing and classifying cycle-to-cycle variability. The assumptions made to establish fast and possibly online methods can alter the distribution of the calculated parameters from cycle-to-cycle, possibly leading to incorrect pattern interpretation and improper control action. Finally, we apply a statistical technique named “permutation entropy” for the first time on classifying combustion patterns in HCCI and SI engine for varying operating conditions. Then, the various fast methods for computing CA50 feed the two statistical methods, permutation and the Shannon entropy, and their differences and similarities are highlighted.
Stabilization of Self-Mode-Locked Quantum Dash lasers by symmetric dual-loop optical feedback: effects of power ratio and optical phase tuning (2020)

We have stabilized self mode-locked quantum dash lasers emitting at 1550nm, reducing pulse train RF linewidth by 100x, using optical feedback from dual fiber loops.
Platelet serotonin uptake in duodenal ulcer patients. (1994)

Platelet serotonin uptake was measured in 10 duodenal ulcer patients and 10 controls by determining the concentration of radioactivity in platelets after incubation with tritium-labelled serotonin binoxalate. Platelet 5-HT uptake in ulcer patients (312.0 +/- 125.0 CPM/10(7) platelets) was significantly higher than that in the control group (186.0 +/- 53.0 CPM/10(7) platelets; p < 0.01). Since the kinetics of 5-HT uptake by platelets may be a reflector of enhanced serotonergic activity, this finding may have implications in future therapeutic strategies for this disease.
Smooth pursuit detection in binocular eye-tracking data with automatic video-based performance evaluation (2016)

An increasing number of researchers record binocular eye-tracking signals from participants viewing moving stimuli, but the majority of event-detection algorithms are monocular and do not consider smooth pursuit movements. The purposes of the present study are to develop an algorithm that discriminates between fixations and smooth pursuit movements in binocular eye-tracking signals and to evaluate its performance using an automated video-based strategy. The proposed algorithm uses a clustering approach that takes both spatial and temporal aspects of the binocular eye-tracking signal into account, and is evaluated using a novel video-based evaluation strategy based on automatically detected moving objects in the video stimuli. The binocular algorithm detects 98% of fixations in image stimuli compared to 95% when only one eye is used, while for video stimuli, both the binocular and monocular algorithms detect around 40% of smooth pursuit movements. The present article shows that using binocular information for discrimination of fixations and smooth pursuit movements is advantageous in static stimuli, without impairing the algorithm's ability to detect smooth pursuit movements in video and moving-dot stimuli. With an automated evaluation strategy, time-consuming manual annotations are avoided and a larger amount of data can be used in the evaluation process.