gebhart/patrepeval huggingface dataset:
Multilanguage interoperability in distributed systems (1996)

The Q system provides interoperability support for multilingual, heterogeneous component-based software systems. Initial development of Q began in 1988, and was driven by the very pragmatic need for a communication mechanism between a client program written in Ada and a server written in C. The initial design was driven by language features present in C, but not in Ada, or vice-versa. In time our needs and aspirations grew and Q evolved to support other languages, such as C++, Lisp, Prolog, Java, and Tcl. As a result of pervasive usage by the Arcadia SDE research project, usage levels and modes of the Q system grew and so more emphasis was placed upon portability, reliability, and performance. In that context we identified specific ways in which programming language support systems can directly impede effective interoperability. This necessitated extensive changes to both our conceptual model and our implementation of the Q system. We also discovered the need to support modes of interoperability far more complex than the usual client-server. The continued evolution of Q has allowed the architecture of Arcadia software to become highly distributed and component-based, exploiting components written in a variety of languages. In addition to becoming an Arcadia project mainstay, and has also been made available to over 100 other sites, and it is currently in use in a variety of other projects. This paper summarizes key points that have been learned from this considerable base of experience.
Integration of model-predictive control in medium and high-voltage power electronics products: An industrial perspective on gaps and progress required (2015)

Model predictive control (MPC) technologies could deliver numerous benefits for power electronic converters and their applications. However, a varying degree of effort is required to integrate such technologies into industrial products. Moreover, the degree of complexity associated with the problem formulation and associated constraints, is linked to a number of unclear benefits for the industrial acceptance of such powerful yet inadequately appreciated control techniques by industry engineers. Translating the benefits of taking into account increased input control parameters for a more accurate and robust control against the classical single-input single-output Proportional-Integral-Derivative (PID) control is a serious challenge when one wishes to integrate such technologies in industrial products. The paper discusses MPC development steps across the spectrum of research, technology development and product development to contribute to the understanding of the challenges that need to be addressed to adopt such technologies into industrial products. The case of Medium-Voltage (MV) motor drives and High-Voltage Direct Current (HVDC) power transmission are considered in the paper. Both steady state and dynamic performance benefits are considered in the discussion and a number of potential paths to address the still limited commercial acceptance of such technologies are presented.
High frequency operation of an integrated electro-absorption modulator onto a vertical-cavity surface-emitting laser (2019)

International audience
Cyclic GMP, sodium nitroprusside and sodium azide reduce aqueous humour formation in the isolated arterially perfused pig eye (2005)

The effect of nitric oxide (NO) on aqueous humour formation (AHF) and intraocular pressure (IOP) was studied using NO donors, sodium azide (AZ) and sodium nitroprusside (SNP). Using the porcine arterially perfused eye preparation, drug effects on AHF and IOP were measured by fluorescein dilution and manometry, respectively. Perfusion pressure of the ocular vasculature was also monitored using digital pressure transducer and pen recorder. L-Arginine (1.0 mM), a precursor of NO, but not D-arginine (1.0 mM), the inactive analogue, produced a significant reduction in AHF (28.5%) and IOP (21.1%). L-NAME (L-nitro-L-arginine) (10-100 microM), an NO synthase inhibitor, had no effect on AHF and IOP. However, L-NAME (100 microM) completely reversed L-arginine's effect. AZ and SNP reduced the AHF and IOP dose-dependently. AZ at 100 nM, 1 and 10 microM reduced AHF by 26.0, 39.7 and 51.7% and IOP by 10.8, 17.3 and 24.0%, respectively. SNP at 1, 10 and 100 microM reduced the AHF by 6.0, 24.2 and 35.4% and IOP by 3.5, 9.5 and 15.5%, respectively. 8-pCPT-cGMP (8-para-chlorophenyl-thioguanosine-3',5'-cyclic guanosine monophosphate, 10 microM), a cGMP analogue, also reduced the AHF (34.9%) and IOP (15.9%). The effects of AZ and SNP on the AHF and IOP were blocked by a soluble guanylate cyclase inhibitor ODQ (10 microM), whereas ODQ alone or combined with 8-pCPT-cGMP had no effect on the AHF and IOP. None of the drugs had any significant effect on ocular vasculature. The reduction of the AHF and IOP in the arterially perfused pig eye by nitrovasodilators is likely to involve the NO-cGMP pathway.
Monolithic Stationary Phases for Capillary Electrochromatography Based on Synthetic Polymers: Designs and Applications (2000)

Monolithic materials have quickly become a well-established stationary phase format in the field of capillary electrochromatography (CEC). Both the simplicity of their in situ preparation method and the large variety of readily available chemistries make the monolithic separation media an attractive alternative to capillary columns packed with particulate materials. This review summarizes the contributions of numerous groups working in this rapidly growing area, with a focus on monolithic capillary columns prepared from synthetic polymers. Various approaches employed for the preparation of the monoliths are detailed, and where available, the material properties of the resulting monolithic capillary columns are shown. Their chromatographic performance is demonstrated by numerous separations of different analyte mixtures in variety of modes. Although detailed studies of the effect of polymer properties on the analytical performance of monolithic capillaries remain scarce at this early stage of their development, this review also discusses some important relationships such as the effect of pore size on the separation performance in more detail.
Video Stabilization and Enhancement (2007)

We describe a simple and computationally efficient approach for video stabilization and enhancement. By combining multiple low-quality video frames, it is possible to extract a high-quality still image. This technique is particularly helpful in identifying people, license plates, etc. from low-quality video surveillance cameras. 1 1
Solubility and stability enhancement of curcumin in Soluplus<sup>®</sup>polymeric micelles: a spectroscopic study (2019)

Polymer micelles are considered to be efficient carriers for solubilizing and stabilizing various hydrophobic drugs. In order to address the problem of poor bioavailability of curcumin, a different approach known as solid dispersion technique has been utilized to develop a formulation of curcumin with a novel amphiphilic polymer – Soluplus®. The mechanism of interaction of curcumin with Soluplus® has been elucidated using UV–vis absorption and steady-state fluorescence spectroscopy. At a molecular level, the reduced interaction of water molecules with curcumin, in the optimized system led to an enhancement of both absorption and emission intensities of curcumin accompanied by a hypsochromic shift in the fluorescence spectra. Furthermore, stability analysis indicated a much better environment for the drug with less than 3% degradation of curcumin in 3 days. The steady state anisotropy studies confirms the presence of a rigid environment for curcumin upon encapsulation by the polymer. The extra stability of this system can be ascribed to the formation of multiple intermolecular H-bonding interactions between curcumin and Soluplus® which is proved by IR spectroscopy. Finally, in vitro cell viability assays indicated that it is a highly safe and effective system that could be further screened for a plethora of biological applications.
Reaction Mechanism Analysis of Di-Air-Contributions of Hydrocarbons and Intermediates (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The details of Di-Air, a new NO&lt;sub&gt;x&lt;/sub&gt; reduction system using continuous short pulse injections of hydrocarbons (HC) in front of a NO&lt;sub&gt;x&lt;/sub&gt; storage and reduction (NSR) catalyst, have already been reported. This paper describes further studies into the deNO&lt;sub&gt;x&lt;/sub&gt; mechanism, mainly from the standpoint of the contribution of HC and intermediates.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;In the process of a preliminary survey regarding HC oxidation behavior at the moment of injection, it was found that HC have unique advantages as a reductant. The addition of HC lead to the reduction or metallization of platinum group metals (PGM) while keeping the overall gas atmosphere in a lean state due to adsorbed HC. This causes local O₂ inhibition and generates reductive intermediate species such as R-NCO.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Therefore, the specific benefits of HC were analyzed from the viewpoints of 1) the impact on the PGM state, 2) the characterization of intermediate species, and 3) Di-Air performance compared to other reductants. As a result, the operando dispersive X-ray adsorption fine structure (DXAFS) method was used to find that HC prolong the metallic state of Pt compared to CO and H₂ during a period of time lasting a number of seconds under a lean atmosphere. Moreover, adsorption species and the catalyst outlet gas compositions during the period when lean gases of NO + O₂ are supplied to the metalized PGM were investigated using FTIR and a mass spectrometer. As a result, under lean conditions, intermediate species such as R-NCO were generated for a number of seconds after the supply of NO + O₂, and these species were changed into N₂.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;In addition, temperature programmed desorption (TPD) results showed that HC intermediate species were more thermally stable and that their adsorption energy was larger compared to that of CO and bulk nitrates stored in a conventional NSR. This result also suggests that these characteristics of HC intermediate species contribute to high NO&lt;sub&gt;x&lt;/sub&gt; conversion under high temperature conditions. Moreover, it was found that HC is superior to other reductants, such as CO and H₂, only when small amounts of reductant are continuously supplied at short intervals under high temperature conditions. This result is different from past experience, which concluded that H₂ was the best reductant in any case. It was concluded that these observations explain the reason why the Di-Air system can achieve high NO&lt;sub&gt;x&lt;/sub&gt; conversion at high temperatures.&lt;/div&gt;&lt;/div&gt;
AlGaN/GaN High Electron Mobility Transistor with Thin Buffer Layers (2003)

An AlGaN/GaN high electron mobility transistor (HEMT) on a high-temperature-grown GaN buffer layer as thin as 0.35 µm has been demonstrated for the first time. The investigation of device characteristics is carried out using fat field-effect transistor (FATFET), ring-type FET and Hall measurements. The field-effect mobility obtained from the FATFET is about 1200 cm2/Vs, whereas the mobility in the buffer layers is around 200 cm2/Vs. A leakage current is found to be due to the non-semi-insulating underlying buffer layers. A two-layer model was adopted to separate the surface channel and buffer channel from Hall measurement data. The surface mobility enhancement can be attributed to the screening effect of ionized impurity and defects by the accumulated electrons.
Corporate Credit, Stock Price Inflation and Economic Fluctuations (2001)

We analyze in this paper the empirical interaction between real corporate credit, real income, real stock prices, the short-term interest rate and inflation for the Netherlands and the United States. The framework is based on a five-variable vector error correction model with economically based restrictions upon the cointegrating vectors. Structure is imposed on the vector error correction model in order to identify the permanent and temporary shocks within the system and we use impulse response functions and forecast error variance decompositions to analyze the interdependencies between the aforementioned variables. Erratic shocks in the real amount of corporate credit and in stock prices could potentially have some impact on inflation in the case of United States and on real output in the Netherlands. However, our structural VAR analysis also shows that the above mentioned erratic shocks only explain a small proportion of the variation in inflation and economic activity, and inflation objective shifts and supply side shocks are much more important determinants for economic fluctuations.
Targeting Jak–Stat Signaling in Experimental Pulmonary Hypertension (2020)

In pulmonary arterial hypertension (PAH), progressive structural remodeling accounts for the pulmonary vasculopathy including the obliteration of the lung vasculature that causes an increase in vascular resistance and mean blood pressure in the pulmonary arteries ultimately leading to right heart failure-mediated death. Deciphering the molecular details of aberrant signaling of pulmonary vascular cells in PAH is fundamental for the development of new therapeutic strategies. We aimed to identify kinases as new potential drug targets that are dysregulated in PAH by means of a peptide-based kinase activity assay. We performed a tyrosine kinase-dependent phosphorylation assay using 144 selected microarrayed substrate peptides. The differential signature of phosphopeptides was used to predict alterations in tyrosine kinase activities in human pulmonary arterial smooth muscle cells (HPASMCs) from patients with idiopathic PAH (IPAH) compared with healthy control cells. Thereby, we observed an overactivation and an increased expression of Jak2 (Janus kinase 2) in HPASMCs from patients with IPAH as compared with controls. <i>In vitro</i>, IL-6-induced proliferation and migration of HPASMCs from healthy individuals as well as from patients with IPAH were reduced in a dose-dependent manner by the U.S. Food and Drug Administration-approved Jak1 and Jak2 inhibitor ruxolitinib. <i>In vivo</i>, ruxolitinib therapy in two experimental models of pulmonary arterial hypertension dose-dependently attenuated the elevation in pulmonary arterial pressure, partially reduced right ventricular hypertrophy, and almost completely restored cardiac index without signs of adverse events on cardiac function. Therefore, we propose that ruxolitinib may present a novel therapeutic option for patients with PAH by reducing pulmonary vascular remodeling through effectively blocking Jak2-Stat3 (signal transducer of activators of transcription)-mediated signaling pathways.
Detecting Exoplanets with a Liquid-Crystal-Based Vortex Coronagraph (2012)

Planets beyond our own solar system are difficult to image directly because of their proximity to significantly brighter stars. In order to suppress the intense starlight, a high-performance optical coronagraph is required, and the optical vortex coronagraph can in theory enable observations very close to stars. The vortex phase masks needed to implement this approach have been manufactured as circularly symmetric half-wave plates made of liquid crystal polymers, and initial on-sky tests have been carried out. This approach has in fact already allowed the successful detection of exoplanets as close as two diffraction beam widths from a bright star, at contrasts of approximately 10−5. Significantly improved performance should be possible in the near future.
Uroplakin III-Delta4 Messenger RNA as a Promising Marker to Identify Nonulcerative Interstitial Cystitis (2007)

Although the clinical implications of the over expression of uroplakin III and III-delta4 in nonulcerative interstitial cystitis bladders remains to be clarified, from the diagnostic viewpoint uroplakin III-delta4 is a potential marker for identifying nonulcerative interstitial cystitis.
Surface Tracking Algorithm for Computing Lagrangian Coherent Structures in a Hurricane Simulation (2012)

We present the results of using a recently developed 3D surface tracking algorithm to compute the Lagrangian coherent structures (LCSs) for a simulation of hurricane Rita (2005). The surface tracking algorithm greatly speeds the LCS computations and results in computing the actual LCS surfaces, rather than just a eld of nite time Lyapunov exponents, as is often done. This allows for simpler and more detailed visualization and analysis of the resulting LCSs. We examine two interesting features of the hurricane LCS: a signicant asymmetry in the eye and the complex \checkerboard pattern LCS in the boundary layer. The asymmetry in the eye results in uid exchange between the eye and the surrounding environment. We also propose a mechanism that reproduces the checkerboard pattern LCS in a simple analytical ow.
Models to identify treatments for the acute and persistent effects of seizure‐inducing chemical threat agents (2016)

Exposures to seizure-inducing chemical threat agents are a major public health concern. Of particular need is improved treatment to terminate convulsions and to prevent the long-term neurological sequelae in survivors. We are studying the organophosphorus cholinesterase inhibitor diisopropyl fluorophosphate (DFP) and the GABA receptor inhibitor tetramethylenedisulfotetramine (TETS), which arguably encompass the mechanistic spectrum of seizure-inducing chemical threats, with the goal of identifying therapeutic approaches with broad-spectrum efficacy. Research efforts have focused on developing translational models and translational diagnostic approaches, including (1) in vivo models of DFP- and TETS-induced seizures for studying neuropathological mechanisms and identifying treatment approaches; (2) in vivo imaging modalities for noninvasive longitudinal monitoring of neurological damage and response to therapeutic candidates; and (3) higher-throughput in vitro platforms for rapid screening of compounds to identify potential antiseizure and neuroprotective agents, as well as mechanistically relevant novel drug targets. This review summarizes our progress toward realizing these goals and discusses best practices and mechanistic insights derived from our modeling efforts.
Development of Electrically Controlled Energetic Materials (ECEM) (2013)

U.S. Army ARDEC has been examining a novel pyroelectric-type material developed by Digital Solid State Propulsion, LLC for its unique combustion properties and insensitivity. This unique ECEM is formed using an ionic liquid oxidizer and polymer fuel, via sol-gel processes and is quite dense, making it very suitable for energetic applications in both the civilian and military fields. This ECEM is completely insensitive to the application of impact, flame, friction, and shock threats. Once a power of the required voltage is applied, the baseline ECEM rapidly initiates combustion with H 2 O, CO 2 , and N 2 formed as the only major gas phase products produced. Initial testing of ECEM in perforated pipes appears promising as indicated by uniform ignition along the entire length of the test assembly.
SOUND LOCALIZATION USING COMPRESSIVE SENSING (2012)

In a sensor network with remote sensor devices, it is important to have a method that can accurately localize a sound event with a small amount of data transmitted from the sensors.In this paper, we propose a novel method for localization of a sound source using compressive sensing.Instead of sampling a large amount of data at the Nyquist sampling rate in time domain, the acoustic sensors take compressive measurements integrated in time.The compressive measurements can be used to accurately compute the location of a sound source.
The Effect of Three-Season Drought on Natural Rubber in Xishuangbanna (2010)

The extremely weather of three seasons from the year of 2009 to 2010 was recorded.This drought caused great loss in natural rubber,i.g.abnormal phenomenon for rubber,seriously pest and disease,tapping time was delayed for 10 to 30 days,less dry rubber,high cost in rubber planting and as well as wind and hail disaster.
Comment on “Theoretical analysis of numerical aperture increasing lens microscopy” [J. Appl. Phys. 97, 053105 (2005)] (2006)

In a recent paper, Ippolito et al. [J. Appl. Phys. 97, 053105 (2005)] analyzed focusing at high numerical aperture into a dielectric medium. They considered three geometries, those of focusing through a level planar interface and through spherical interfaces arranged in concentric or aplanatic positions. The treatment for focusing through a planar interface is based on a different model from that presented elsewhere. It is shown that this model describes the aberration effect only approximately, in contrast to the previous, rigorous treatment.
Collinear ferromagnetism and spin orientation in the molecule-based magnets<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>M</mml:mi><mml:mo>[</mml:mo><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">N</mml:mi><mml:mo>(</mml:mo><mml:mi mathvariant="normal">CN</mml:mi><mml:mo>)</mml:mo><mml:mn/></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mo>]</mml:mo></mml:mrow><mml:mrow><mml:mn>2</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mo>(</mml:mo><mml:mi>M</mml:mi><mml:mo>=</mml:mo><mml:mi mathvariant="normal">Co</mml:mi><mml:mo>,</mml:mo></mml:math>Ni) (1999)

Zero-field unpolarized neutron powder diffraction has been used to study the low-$T$ magnetic structure and T-dependent crystal structure of $M[{\mathrm{N}(\mathrm{CN})}_{2}{]}_{2}$ $(M=\mathrm{Co},$Ni). Both compounds show collinear ferromagnetism with spin orientation along the c axis. The results provide the determination of a complete magnetic structure in the ordered state for a molecule-based magnet. The c lattice parameter exhibits negative thermal expansion, explained by a wine-rack-like deformation.
Development of a self-replicating plasmid system for Mycoplasma hyopneumoniae (2013)

Mycoplasma hyopneumoniae is a prevalent swine respiratory pathogen that is a major cause of economic loss to pig producers. Control is achieved by a combination of antimicrobials, vaccination and management practices, but current vaccines offer only partial control and there is a need for improved preventative strategies. A major barrier to advances in understanding the pathogenesis of M. hyopneumoniae and in developing new vaccines is the lack of tools to genetically manipulate the organism. We describe the development and optimisation of the first successful plasmid-based system for the genetic manipulation of M. hyopneumoniae. Our artificial plasmids contain the origin of replication (oriC) of M. hyopneumoniae along with tetM, conferring resistance to tetracycline. With these plasmids, we have successfully transformed M. hyopneumoniae strain 232 by electroporation, generating tetracycline resistant organisms. The persistence of extrachromosomal plasmid and maintenance of plasmid DNA over serial passages shows that these artificial plasmids are capable of self-replication in M. hyopneumoniae. In addition to demonstrating the amenability of M. hyopneumoniae to genetic manipulation and in optimising the conditions necessary for successful transformation, we have used this system to determine the minimum functional oriC of M. hyopneumoniae. In doing so, we have developed a plasmid with a small oriC that is stably maintained over multiple passages that may be useful in generating targeted gene disruptions. In conclusion, we have generated a set of plasmids that will be valuable in studies of M. hyopneumoniae pathogenesis and provide a major step forward in the study of this important swine pathogen.