gebhart/patrepeval huggingface dataset:
European R&amp;D Trends in wire bonding technologies (2012)

Asian industry and development is currently very focused on replacing extremely expensive Au wire with Cu or Pd-plated Cu in IC (mass production) packaging technologies (ball/wedge bonding). In contrast, Europe traditionally is researching and developing in the field of wedge/wedge bonding using heavy wire (&amp;gt; 100 μm) for power electronic modules or standard (thin) wire (&amp;lt; 100 μm, mostly 25–50 μm) for chip-on-board (COB) applications. One primary failure mechanism limiting the lifetime of power modules is Al wedge lift-off due to the different coefficients of thermal expansion (CTE) of the Al wedge and the chip (Si). This classical type of fatigue cracking can be reduced by using materials of higher strength and/or lower CTE. Key strategies include doping or alloying elements and/or optimizing bonding conditions to improve the microstructure. Cu-based wire or Cu-Al bimetal ribbons are another option, although these include changes to the chip structure and metallization. AlSi1 has been the industry standard bonding material in wedge/wedge thin wire bonding for many years. Its thermal stability is limited at temperature above ≈100°C due to recrystallization, grain growth and Si coagulation. For example, glob top material curing processes used in chip on board (COB) applications (e.g. several hours at 160°C) can decrease the strength of standard AlSi1 wire to less than 60% of its original value. Research and development is currently attempting to improve this situation by alloying and doping Al base material to increase high-temperature behavior or by using Al-coated Au or Cu wires. The presentation will give an overview of alternative wedge/wedge wire bonding materials and discuss the challenges to processing and reliability.
Selective Effects of Oxygen Free Radicals on Excitation-Contraction Coupling in Ventricular Muscle (1996)

These results indicate that exposure to the H2O2 + Fe3+ free radical-generating system reduces activator Ca2+ availability, whereas XO + P decreases the Ca2+ sensitivity of the myofilaments. Exogenously generated OFRs, particularly those produced by XO + P, mimic the effects of myocardial stunning on cardiac excitation-contraction coupling.
Albuminuria: Prevalence, associated risk factors and relationship with cardiovascular disease (2013)

The prevalence of albuminuria was high in the general Chinese population. Aging, female sex, hypertension, hyperglycemia, dyslipidemia, insulin resistance, obesity and metabolic syndrome were all independent risk factors for albuminuria. The causal relationship between ACR and CVD might require further follow-up investigation.
Binary colloidal glasses under transient stress- and strain-controlled shear (2017)

We investigate the yielding and transition to flow of different colloidal glasses. Using a single model system, a binary mixture of colloidal hard spheres with different compositions and size ratios, we study single, double and asymmetric glasses, which differ in the degree of mobility of the small particles and the caging mechanisms of the large spheres. The rheological response following either a step to a constant shear rate or to a constant stress (creep) is measured and the two responses are quantitatively compared. Although the same steady state of flow is observed at long times, the transient responses in strain- and stress-controlled experiments differ significantly. To achieve yielding and a steady state of flow, less time and less energy input is required if a constant strain rate is applied. Moreover, larger strain rates or stresses result in faster yielding and flow, but require more total energy input. If a constant strain rate is applied, yielding and the transition to flow depend on the properties of the glass state, while much smaller differences are observed if a constant stress is applied.
An experimental comparison of localization methods (2002)

Localization is the process of updating the pose of a robot in an environment, based on sensor readings. In this experimental study, we compare two methods for localization of indoor mobile robots: Markov localization, which uses a probability distribution across a grid of robot poses; and scan matching, which uses Kalman filtering techniques based on matching sensor scans. Both these techniques are dense matching methods, that is, they match dense sets of environment features to an a priori map. To arrive at results for a range of situations, we utilize several different types of environments, and add noise to both the dead-reckoning and the sensors. Analysis shows that, roughly, the scan-matching techniques are more efficient and accurate, but Markov localization is better able to cope with large amounts of noise. These results suggest hybrid methods that are efficient, accurate and robust to noise.
Three-Dimensional Quantum Confinement of Charge Carriers in Self-Organized AlGaN Nanowires: A Viable Route to Electrically Injected Deep Ultraviolet Lasers (2015)

We report on the molecular beam epitaxial growth and structural characterization of self-organized AlGaN nanowire arrays on Si substrate with high luminescence efficiency emission in the deep ultraviolet (UV) wavelength range. It is found that, with increasing Al concentration, atomic-scale compositional modulations can be realized, leading to three-dimensional quantum confinement of charge carriers. By further exploiting the Anderson localization of light, we have demonstrated, for the first time, electrically injected AlGaN lasers in the deep UV band operating at room temperature. The laser operates at ∼289 nm and exhibits a threshold of 300 A/cm(2), which is significantly smaller compared to the previously reported electrically injected AlGaN multiple quantum well lasers.
Sensitivity of reentrant driver localization to electrophysiological parameter variability in image-based computational models of persistent atrial fibrillation sustained by a fibrotic substrate (2017)

Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia, causing morbidity and mortality in millions worldwide. The atria of patients with persistent AF (PsAF) are characterized by the presence of extensive and distributed atrial fibrosis, which facilitates the formation of persistent reentrant drivers (RDs, i.e., spiral waves), which promote fibrillatory activity. Targeted catheter ablation of RD-harboring tissues has shown promise as a clinical treatment for PsAF, but the outcomes remain sub-par. Personalized computational modeling has been proposed as a means of non-invasively predicting optimal ablation targets in individual PsAF patients, but it remains unclear how RD localization dynamics are influenced by inter-patient variability in the spatial distribution of atrial fibrosis, action potential duration (APD), and conduction velocity (CV). Here, we conduct simulations in computational models of fibrotic atria derived from the clinical imaging of PsAF patients to characterize the sensitivity of RD locations to these three factors. We show that RDs consistently anchor to boundaries between fibrotic and non-fibrotic tissues, as delineated by late gadolinium-enhanced magnetic resonance imaging, but those changes in APD/CV can enhance or attenuate the likelihood that an RD will anchor to a specific site. These findings show that the level of uncertainty present in patient-specific atrial models reconstructed without any invasive measurements (i.e., incorporating each individual's unique distribution of fibrotic tissue from medical imaging alongside an average representation of AF-remodeled electrophysiology) is sufficiently high that a personalized ablation strategy based on targeting simulation-predicted RD trajectories alone may not produce the desired result.
Apohemoglobin-Haptoglobin Complex Prevents Microvascular Dysfunction in Sickle Cell Mice: Potential Therapeutic Approach for Vaso-Occlusive Crisis (2022)

Background: Sickle cell disease (SCD) is associated with episodes of vaso-occlusive events (VOE) caused by the effects of hemoglobin S (HbS) polymerization in red blood cells (RBCs) and resultant hemolysis. In the acute setting, treatment for VOE is limited to supportive care such as hydration and aggressive pain management as no specific therapies can alter the course of acute VOE. The apohemoglobin-haptoglobin (apoHb-Hp) complex is a two-protein formulation that is capable of scavenging and neutralizing the toxic effects of cell-free hemoglobin (Hb) and heme released from the hemolysis of polymerized HbS RBCs. The primary objective of this study was to evaluate the microcirculatory effects of apoHb-Hp during hypoxia-induced VOE. Methods: The effects of apoHb-hp was studied in a mouse model of SCD using sickle cell transgenic mice (HbSS-Towne's mice, and compared to mice expressing normal human Hb (HbAA-Towne's mice). Each group consisted of 11 mice, they were initially kept in normal conditions (21% O2) for an hour followed by a hypoxic state (7% O2) for another hour and finally brought back to normal conditions (21% O2) for an hour before being sacrificed. ApoHb-hp (60 mg/mL) and Hp (85 mg/mL) were injected intravenously to yield equimolar total heme and Hb binding capacity between treatments prior to hypoxia exposure. During baseline, hypoxia and normoxia systemic parameters (mean arteriole pressure and heart rate), blood gases (pO2,A, pO2,v, sO2,A, sO2,v), hematological properties (total Hb concentration, hematocrit, and concentration of lactate) and microcirculatory hemodynamics (velocity, diameter, flow and functional capillary density) were measured. After the mice were sacrificed a count of present macrophages, neutrophils and lymphocytes were quantified in the pulmonary tissue. Results: There was no notable changes in blood gas concentrations with any of the treatments. ApoHb-Hp treatment improved microcirculatory hemodynamics of HbSS mice by preventing hypoxia-induced vasoconstriction and reduction of blood flow in arterioles <40µm (P=0.818, P<0.0001), arterioles >40 µm (P>0.9999, P<0.0001) and venules 20<x<60 µm (P=0.150, P=0.330) compared to HbAA mice. Furthermore, the functional capillary density saw favorable recovery to baseline when HbSS mice were treated with apoHb-Hp seeing a 36% drop initially, 50% drop after 24 hours, 35% drop after 48 hours, and 27% drop after 72 hours. For comparison, HbSS mice that didn't receive treatment saw a 50% drop initially, 77% drop after 24 hours, 80% drop after 48 hours, and 72% drop after 72 hours when compared to baseline. Conclusion: These results suggest a role for ApoHb-Hp complex in alleviating microvascular changes occurring during hypoxia mediated acute vaso-occlusion in SCD and merits further study for development as a potential therapeutic. Figure 1View largeDownload PPTFigure 1View largeDownload PPT Close modal
Downlink User Capacity in a CDMA Macrocell with a Hotspot Microcell (2005)

This paper examines the downlink user capacity in a CDMA system composed of a macrocell and a microcell, where both cells use the same frequency channel. The effect of channel dispersion on the number of simultaneous users supported is studied for three different downlink power control methods. Channel dispersion produces in-cell interference and variable fading of the received signal power. Novel analytical methods are developed to account for both effects; these techniques derive user capacity for any delay profile using the results for the uniform delay profile. The downlink user capacities for the three power control methods are compared to the uplink user capacity under the same channel conditions. The results point to the need for fast power control to obtain uplink-limited performance.
On the Efficacy of a Fused CPU+GPU Processor (or APU) for Parallel Computing (2011)

The graphics processing unit (GPU) has made significant strides as an accelerator in parallel computing. However, because the GPU has resided out on PCIe as a discrete device, the performance of GPU applications can be bottlenecked by data transfers between the CPU and GPU over PCIe. Emerging heterogeneous computing architectures that "fuse" the functionality of the CPU and GPU, e.g., AMD Fusion and Intel Knights Ferry, hold the promise of addressing the PCIe bottleneck. In this paper, we empirically characterize and analyze the efficacy of AMD Fusion, an architecture that combines general-purposex86 cores and programmable accelerator cores on the same silicon die. We characterize its performance via a set of micro-benchmarks (e.g., PCIe data transfer), kernel benchmarks(e.g., reduction), and actual applications (e.g., molecular dynamics). Depending on the benchmark, our results show that Fusion produces a 1.7 to 6.0-fold improvement in the data-transfer time, when compared to a discrete GPU. In turn, this improvement in data-transfer performance can significantly enhance application performance. For example, running a reduction benchmark on AMD Fusion with its mere 80 GPU cores improves performance by 3.5-fold over the discrete AMD Radeon HD 5870 GPU with its 1600 more powerful GPU cores.
Low threshold vertical-cavity surface-emitting lasers based on high contrast distributed Bragg reflectors (1997)

Data are presented on vertical-cavity surface-emitting lasers that use high contrast distributed Bragg reflectors on both sides of the cavity. The upper reflector consists of a six pair ZnSe/MgF quarter-wave stack, while the lower reflector consists of an eleven pair AlxOy/GaAs stack fabricated using selective oxidation. Strain due to the lower reflector is reduced by using AlxOy layers of less than a quarter-wave thickness. Device sizes ranging from 1 to 7 μm diameters are characterized, with a minimum threshold current of 53 μA.
Experimental Analysis of E-Glass/Epoxy and E-Glass/Polyester Composites for Auto Body Panel (2015)

In this paper Experimental characterization of the mechanical properties of E-glass/Epoxy & E- glass/Polyester composite was conducted. The objectives of this paper is to present processing techniques of specimen preparation, conducting experiment to obtain mechanical properties and conduct experimental observation using Scanning Electron Microscopy (SEM) to know inhomogeneity, porosity and fracture behavior. The effect of strain rate on E-glass/epoxy and E-glass/polyester has been investigated & experimentation was performed to determine property data for material specifications. E-glass/polyester laminates were obtained by compression molding process and E-glass/epoxy laminate by hand lay-up vacuum assisted technique. The laminates were cut to obtain ASTM standards. This investigation deals with the testing of tensile, compression, shear and flexural strength on a universal testing machine. The graphs that are obtained from the tests were documented. This research indicates that the mechanical properties are mainly dependent on the strain rate.
Protein kinase C activators inhibit the antigen receptor‐coupled polyphosphoinositide phosphodiesterase in murine B lymphocytes (1988)

Protein kinase C activators (e.g. PMA) inhibit the inositol phosphate release generated by crosslinking antigen receptors (sIgM and sIgD) on murine B lymphocytes with anti-receptor antibodies. Unlike other Ca2+-mobilizing receptor systems, the antigen receptor signal transduction pathway in B cells is not interrupted by PMA at the level of receptor/G-protein or G-protein/polyphosphoinositide phosphodiesterase coupling. In these cells, PMA, presumably by activating protein kinase C, inhibits inositol phosphate release by direct effects on the polyphosphoinositide-specific phosphodiesterase.
Fabrication of Si-substituted hydroxyapatite foam using calcium silicates (2008)

Silicon-substituted hydroxyapatite (Si-HAP) foam may be an ideal bone substitute since Si-HAP has stimulating effect for bone formation and the foam morphology provides interconnected macro porous structure which is ideal for bone formation. However, lower temperature was reported to be required for the fabrication of pure Si-HAP whereas higher temperature was required for the fabrication of HAP foam. In the present investigation, three calcium silicate compounds (CaSiO3, wollastonite; Ca2SiO4, belite; Ca3SiO5, alite) were evaluated for their feasibility as a silicon source for the fabrication of Si-HAP foam. Sintering temperature at 1300°C resulted in a very weak HAP foam, whereas sintering at 1400°C resulted in HAP foam with improved compressive strength up to approximately 9 kPa. XRD analysis showed the appearance of a secondary phase, α-tricalcium phosphate, when wollastonite was used as the silicon source. In contrast, pure Si-HAP phase was obtained when belite or alite was used as the silicon source. The porosities of the Si-HAP foams were approximately 95% regardless of composition of the foam. We therefore concluded that Si-HAP foam with fully interconnecting pores could be fabricated when belite or alite was used as the silicon source. Further evaluation is expected based on this initial finding.
ChemInform Abstract: Transannular, Decarboxylative Claisen Rearrangement Reactions for the Synthesis of Sulfur‐Substituted Vinylcyclopropanes. (2010)

Abstract The treatment of lactone (I) with BSA at room temperature leads to carboxylic acid (II), whilst the reaction under microwave irradiation gives rise to trans‐cyclopropylsulfone (III).
Atomtronics with a spin: Statistics of spin transport and nonequilibrium orthogonality catastrophe in cold quantum gases (2019)

We propose to investigate the full counting statistics of nonequilibrium spin transport with an ultracold atomic quantum gas. The setup makes use of the spin control available in atomic systems to generate spin transport induced by an impurity atom immersed in a spin-imbalanced two-component Fermi gas. In contrast to solid-state realizations, in ultracold atoms spin relaxation and the decoherence from external sources is largely suppressed. As a consequence, once the spin current is turned off by manipulating the internal spin degrees of freedom of the Fermi system, the nonequilibrium spin population remains constant. Thus one can directly count the number of spins in each reservoir to investigate the full counting statistics of spin flips, which is notoriously challenging in solid-state devices. Moreover, using Ramsey interferometry, the dynamical impurity response can be measured. Since the impurity interacts with a many-body environment that is out of equilibrium, our setup provides a way to realize the nonequilibrium orthogonality catastrophe. Here, even for spin reservoirs initially prepared in a zero-temperature state, the Ramsey response exhibits an exponential decay, which is in contrast to the conventional power-law decay of Anderson's orthogonality catastrophe. By mapping our system to a multistep Fermi sea, we are able to derive analytical expressions for the impurity response at late times. This allows us to reveal an intimate connection of the decay rate of the Ramsey contrast and the full counting statistics of spin flips.
The effect of farrowing crate heat lamp location on sow and pig patterns of lying and pig survival. (1998)

Three experiments were conducted to study sow and pig behavior during the 1st 3 d after birth and pig survival during the 1st 2 wk after farrowing. In Exp. 1, 23 sows were housed in conventional farrowing crates that were divided into five sections: a .5- x 1.5-m front creep section and the remaining area divided into four sections, .75 x 1.05 m each. Air temperature was maintained at 19 degrees C, and a 250-W heat lamp was placed at the right side of the front creep in Treatment 1 (T1), or in the creep at the right side of the sow for Treatment 2 (T2). The percentage of pigs within 8 cm of the sow's trunk was not affected by treatment, but it decreased (P < .001) from 61.8 +/- 3.4% on d 1 to 28.1 +/- 3.5% on d 3. As the percentage of pigs near the sow decreased, the percentage of pigs within the section containing the heat lamp increased (T1, P < .05; T2, P < .10). Experiment 2 involved 15 sows and litters housed as in Exp. 1, except that heat lamps were not provided, and average air temperature was 27.3 +/- .2 degrees C during behavioral observations. Even though the portion of the litter near the sow decreased (P < .001) from d 1 to d 3 (d 1, 57.0 +/- 3.4%; d 2, 42.9 +/- 3.3%; d 3, 31.7 +/- 3.3%), pigs did not concentrate in any specific section as they moved away from the sow. The average number of pigs within the front creep section (Section 1) for the 3-d period was less than (P < .01) the number in any other crate section. Experiment 3 involved 147 sows and tested the effect of solid creep floor covering on pig survival for each of the heat lamp locations used in Exp. 1. Neither heat lamp location nor floor covering affected pig survival. During the 1st 3 d of life, pigs tend to lie near the sow regardless of heat lamp location or air temperature. Heat lamp position and floor covering under the lamp do not affect pig survival.
Variational Bayes for continuous hidden Markov models and its application to active learning (2006)

In this paper, we present a varitional Bayes (VB) framework for learning continuous hidden Markov models (CHMMs), and we examine the VB framework within active learning. Unlike a maximum likelihood or maximum a posteriori training procedure, which yield a point estimate of the CHMM parameters, VB-based training yields an estimate of the full posterior of the model parameters. This is particularly important for small training sets since it gives a measure of confidence in the accuracy of the learned model. This is utilized within the context of active learning, for which we acquire labels for those feature vectors for which knowledge of the associated label would be most informative for reducing model-parameter uncertainty. Three active learning algorithms are considered in this paper: 1) query by committee (QBC), with the goal of selecting data for labeling that minimize the classification variance, 2) a maximum expected information gain method that seeks to label data with the goal of reducing the entropy of the model parameters, and 3) an error-reduction-based procedure that attempts to minimize classification error over the test data. The experimental results are presented for synthetic and measured data. We demonstrate that all of these active learning methods can significantly reduce the amount of required labeling, compared to random selection of samples for labeling.
Landscapes of binding antibody and T-cell responses to pox-protein HIV vaccines in Thais and South Africans (2020)

Our approach can be used to advance vaccine development objectives, including the characterization and comparison of candidate vaccine multivariate immune responses and improved design of studies to identify correlates of protection. For instance, results suggested that HVTN 702 will have adequate power to interrogate immune correlates involving anti-V1V2 IgG/IgG3 and CD4+ T-cell co-readouts, but will have lower power to study anti-gp120/gp140 IgG/IgG3 due to their lower dynamic ranges. The findings also generate hypotheses for future testing in experimental and computational analyses aimed at achieving a mechanistic understanding of vaccine-elicited immune response heterogeneity.