gebhart/patrepeval huggingface dataset:
Correlating Lithium Hydroxyl Accumulation with Capacity Retention in V<sub>2</sub>O<sub>5</sub> Aerogel Cathodes (2016)

V2O5 aerogels are capable of reversibly intercalating more than 5 Li(+)/V2O5 but suffer from lifetime issues due to their poor capacity retention upon cycling. We employed a range of material characterization and electrochemical techniques along with atomic pair distribution function, X-ray photoelectron spectroscopy, and density functional theory to determine the origin of the capacity fading in V2O5 aerogel cathodes. In addition to the expected vanadium redox due to intercalation, we observed LiOH species that formed upon discharge and were only partially removed after charging, resulting in an accumulation of electrochemically inactive LiOH over each cycle. Our results indicate that the tightly bound water that is necessary for maintaining the aerogel structure is also inherently responsible for the capacity fade.
Phase I/II study of LAG525 ± spartalizumab (PDR001) in patients (pts) with advanced malignancies. (2018)

3012 Background: LAG525 and spartalizumab (PDR001), humanized IgG4 mAbs, block binding of LAG-3 to MHC class II and PD-1 to PD-L1 and PD-L2, respectively. Preclinical studies show synergistic anti-tumor activity when blocking PD-1 and LAG-3. Here, we report dose escalation results from a Phase I/II study of LAG525 ± spartalizumab in advanced malignancies (NCT02460224). Methods: LAG525 was dosed Q2W (1–15 mg/kg, or 240/400 mg) or Q4W (3–10 mg/kg, or 400 mg); LAG525 + spartalizumab was dosed at 15 dose levels/schedules from 0.3 mg/kg LAG525 + 1 mg/kg spartalizumab Q2W to 1000 mg LAG525 + 400 mg spartalizumab Q4W. Phase I endpoints (dose-limiting toxicities [DLTs], additional safety, pharmacokinetics, efficacy, and biomarkers) were used along with an adaptive Bayesian logistic regression model guided by escalation with overdose control to support future study dosing. Baseline and on-treatment tumor samples were collected. Results: As of 31 Jul 2017, 115/119 pts (97%) receiving LAG525 and 99/121 pts (82%) receiving LAG525 + spartalizumab had discontinued treatment, primarily due to progressive disease (79% and 67%, respectively). DLTs occurred in 4 pts in each arm (LAG525 arm: Gr 3 intra-abdominal fluid collection, lipase increase, vomiting; Gr 4 acute kidney injury. Combination arm: Gr 3 hyperglycemia, pneumonitis, brain tumor edema, fatigue; Gr 4 autoimmune hepatitis) without clear dose relationship. Common (≥10%) related AEs were fatigue (10%) for LAG525 alone and fatigue (18%), diarrhea (15%), and nausea (12%) for the combination. Gr 3–4 related AEs were reported in 10 pts (8%) in the LAG525 arm and 10 pts (8%) in the combination arm. Approximately dose-proportional increases in LAG525 exposure were seen. No MTD was identified for either arm. LAG525 + spartalizumab led to durable RECIST responses (11 PR, 1 CR) in a variety of solid tumors, including mesothelioma (2/8 pts) and triple-negative breast cancer (TNBC; 2/5 pts). In TNBC tumor biopsies, a trend in conversion of immune-cold to immune-activated biomarker profiles was seen. Conclusions: Treatment was well tolerated with preliminary anti-tumor activity and immune profile modulation observed for LAG525 + spartalizumab. Phase II is ongoing in selected indications. Clinical trial information: NCT02460224.
Professor Alvin L. Storrs 1950-2010 In Memoriam (2010)

Article published in the Michigan State Law Review.
FORCED VITAL CAPACITY AND THE RISK OF HYPERTENSION (1988)

This report describes the development of hypertension among 1,270 males (aged 23-80 years at the time of entry into the study) observed prospectively for 10 years who had a baseline blood pressure of less than 140/90 mmHg and who underwent baseline spirometry. Subjects were participants in the Normative Aging Study, a longitudinal study on aging initiated in 1961 at the Veterans Administration Outpatient Clinic in Boston, Massachusetts. Blood pressures were taken at five- and 10-year follow-up examinations. The age-adjusted incidence of hypertension during the follow-up period was found to be inversely related to forced vital capacity. Multiple logistic regression was employed to assess the relation of forced vital capacity to the subsequent development of hypertension after controlling for baseline levels of age, weight, cigarettes smoked per day, and systolic and diastolic blood pressures. Forced vital capacity was a statistically significant and negative predictor, indicating that lower values of forced vital capacity were associated with the subsequent development of hypertension. This was consistently found in several logistic regression analyses with a standardized odds ratio associated with forced vital capacity of approximately 0.7. Although the physiologic mechanism for this association is unknown, these findings may have importance in identifying subjects at risk and may also provide insight into disease pathogenesis.
Low fill factor diode laser bars with high brilliance from 808 nm to 1020 nm for fibre coupling (2009)

In recent years high brilliance semiconductor diode lasers are gaining attraction for the industrial laser market. The emerging generation of multi kilowatt fibre lasers require brilliant pump sources and additionally fibre coupled direct diode lasers increasingly compete with solid state lasers in many industrial areas. This paper investigates diode lasers, which combine several advantages from single emitters and high fill factor laser bars when considering fibre coupling applications. New facet technologies enable the laser to be driven at higher powers per emitter allowing a reduction in fill factor without penalty in total output power per laser bar. These low fill factor bars enable reliable and efficient operation at output power densities comparable to single emitters. The resulting beam parameters allow coupling into a single fibre with low effort in beam shaping or fibre combining.
The role played by oxygen plasma on Teflon: relevance to the concept of “cryptoelectrons” (2012)

Dr Williams (AIP Adv., 2012, 2, 010701) suggested that cleaning Teflon by high pressure oxygen plasma may have affected our result that Cu(2+) and Pd(2+) ions can be absorbed but not chemically reduced by a Teflon surface rubbed by PMMA (Phys. Chem. Chem. Phys., 2012, 14, 5551). In response, we show that this treatment does not affect the adsorption of Cu(2+) and Pd(2+). We reaffirm our statement that Cu(2+) and Pd(2+) ions can be adsorbed by a Teflon surface only after rubbing with the organic polymers, not before rubbing.
Supplementary Figures S1-S2 from The Proliferative Activity of Mammary Epithelial Cells in Normal Tissue Predicts Breast Cancer Risk in Premenopausal Women (2023)

&lt;p&gt;Image analysis of benign breast lesions (S1); Boxplots of the percentage of p27+, ER+, and Ki67+ cells in benign breast lesions (S2).&lt;/p&gt;
ChemInform Abstract: A Flexible, Practical, and Stereoselective Synthesis of Enantiomerically Pure trans‐5‐Oxohexahydropyrrolo[3,2‐b]pyrroles (Pyrrolidine‐trans‐lactams) (I), a New Class of Serine Protease Inhibitors, Using Acyliminium Methodology. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Procedure for the Removal of Insect Specimens from Sticky-trap Material (1985)

Correct identification of specimens is crucial to the cost-effective operation of insect population studies and biological control programs. Traps containing sticky materials are often used to detect and allow the quantification of populations of certain kinds of insects. Removal of insect specimens from such materials is frequently necessary for accurate identification. Provided here are instructions for removing insects from the most widely used sticky material, polyisobutylene, by use of specific solvents, as well as for washing and preparing cleaned specimens for microscopic examination.
Mathematical Aspects of Geometric Modeling (1995)

Preface A brief overview 1. Matrix subdivision 2: Stationary subdivision 3: Piecewise polynomial curves 4: Geometric methods for piecewise polynomial surfaces 5: Recursive algorithms for polynomial evaluation.
Single‐Walled Carbon Nanotubes Modified Gold Electrodes as an Impedimetric DNA Sensor (2009)

Abstract A gold surface modified with a self‐assembled monolayer of 11‐amino‐1‐undecanethiol (AUT) was used for the covalent immobilization of oxidized single‐walled carbon nanotubes (SWNTs). The as‐described SWNTs‐modified substrate was subsequently used to attach single‐stranded deoxyribonucleic acid (ssDNA) used as a substrate for DNA hybridization. Electrochemical impedance spectroscopy measurements were performed to follow the DNA hybridization process by using the redox couple [Fe(CN) 6 ] 3−/4− as a marker ion. Specifically, changes in charge transfer resistance obtained from the Nyquist plots were used as the sensing parameter of DNA hybridization. The substrate sensitivity towards changes in target DNA concentration, its selectivity toward different DNA sequences and its reusability are successfully demonstrated in this report.
Rapamycin inhibits proteasome activator expression and proteasome activity (1997)

Rapamycin (RAPA) is a potent immunosuppressive drug, and certain of its direct or indirect targets might be of vital importance to the regulation of an immune response. In this study, we used differential hybridization to search for human genes whose expression was sensitive to RAPA. Seven RAPA-sensitive genes were found and one of them encoded a protein with high homology to the alpha subunit of a proteasome activator (PA28 alpha). This gene was later found to code for the beta subunit of the proteasome activator (PA28 beta). Activated T and B cells had up-regulated PA28 beta expression at the mRNA level. Such up-regulation could be suppressed by RAPA, FK506, and cyclosporin A. RAPA and FK506 also repressed the up-regulated PA28 alpha messages in phytohemagglutinin (PHA)-stimulated T cells. At the protein level, RAPA inhibited PA28 alpha and PA28 beta in the activated T cells according to immunoblotting and confocal microscopy. Probably as a consequence, there was a fourfold increase of proteasome activities in the peripheral blood mononuclear cell lysate after the PHA activation. RAPA could inhibit the enhanced part of the proteasome activity. Considering the critical role played by the proteasome in degrading regulatory proteins, our data suggest that the proteasome activator is a relevant and important downstream target of rapamycin, and that the immune response could be modulated through the activity of the proteasome.
Soft x-ray continuum radiation transmitted through metallic filters: An analytical approach to fast electron temperature measurements (2010)

A new set of analytic formulas describes the transmission of soft x-ray continuum radiation through a metallic foil for its application to fast electron temperature measurements in fusion plasmas. This novel approach shows good agreement with numerical calculations over a wide range of plasma temperatures in contrast with the solutions obtained when using a transmission approximated by a single-Heaviside function [S. von Goeler et al., Rev. Sci. Instrum. 70, 599 (1999)]. The new analytic formulas can improve the interpretation of the experimental results and thus contribute in obtaining fast temperature measurements in between intermittent Thomson scattering data.
p90 ribosomal S6 kinase 2 is associated with and dephosphorylated by protein phosphatase 2Cδ (2004)

RSK2 (p90 ribosomal S6 kinase 2) is activated via the ERK (extracellular-signal-regulated kinase) pathway by phosphorylation on four sites: Ser227 in the activation loop of the N-terminal kinase domain, Ser369 in the linker, Ser386 in the hydrophobic motif and Thr577 in the C-terminal kinase domain of RSK2. In the present study, we demonstrate that RSK2 is associated in vivo with PP2Cδ (protein phosphatase 2Cδ). In epidermal growth factorstimulated cells, RSK2 is partially dephosphorylated on all four sites in an Mn2+-dependent manner, leading to reduced protein kinase activity. Furthermore, PP2Cδ is phosphorylated by ERK on Thr315 and Thr333 in the catalytic domain. Mutation of Thr315 and Thr333 to alanine in a catalytically inactive mutant PP2Cδ(H154D) (His154→Asp) increases the association with RSK2 significantly, whereas mutation to glutamate, mimicking phosphorylation, reduces the binding of RSK2. The domains of interaction are mapped to the N-terminal extension comprising residues 1–71 of PP2Cδ and the N-terminal kinase domain of RSK2. The interaction is specific, since PP2Cδ associates with RSK1–RSK4, MSK1 (mitogen- and stress-activated kinase 1) and MSK2, but not with p70 S6 kinase or phosphoinositide-dependent kinase 1. We conclude that RSK2 is associated with PP2Cδ in vivo and is partially dephosphorylated by it, leading to reduced kinase activity.
Identification and management of cancer cachexia in patients: Assessment of healthcare providers' knowledge and practice gaps (2022)

Findings from this international assessment highlight the challenges associated with the care of patients with cancer cachexia, opportunities for interventions to improve patient outcomes and areas of variance in care that would benefit from further analysis.
Domain imaging in magnetic garnets using tunneling-stabilized magnetic force microscopy (1992)

Magnetic domains in low-coercivity magnetic garnets have been imaged using tunneling-stabilized magnetic force microscopy (TSMFM). In TSMFM, a triangular, Au-coated, thin-film, Ni-spring tunneling tip flexes in response to the sample's fringing magnetic field as the tip is scanned across the Au-coated garnet sample. The magnetic garnet is an epitaxial YGdTmGa/YSmTmGa film, grown on a nonmagnetic Gd/sub 3/Ga/sub 5/O/sub 12/ (GGG) substrate, with a zero-field stripe width of 2.2 mu m. The Ni tip does not appear to disturb the garnet's domain structure despite the garnet's low coercivity, nor does the magnetization from the garnet appear to disturb the Ni tip. The shape and period of the contrast observed with TSMFM are consistent with magnetic domain patterns measured using ferrofluid decoration and magnetooptic Faraday-effect imaging.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Elevated Levels of Phosphorylated Fibrinogen-α-Iso-forms and Differential Expression of Other Post-Translationally Modified Proteins in the Plasma of Ovarian Cancer Patients <i>J. Proteome Res</i>. <b>2006</b>,<i> 5</i>, 3318−3325. (2007)

ADVERTISEMENT RETURN TO ISSUEPREVAdditions & Corr...Additions & CorrectionsORIGINAL ARTICLEThis notice is a correctionElevated Levels of Phosphorylated Fibrinogen-α-Iso-forms and Differential Expression of Other Post-Translationally Modified Proteins in the Plasma of Ovarian Cancer Patients J. Proteome Res. 2006, 5, 3318−3325.Yuko Ogata, Carrie J. Heppelmann, M. Cristine Charlesworth, Benjamin J. Madden, Melinda N. Miller, Kimberly R. Kalli, William A. Cilby, H. Robert Bergen, Diana A. Saggese, and David C. MuddimanCite this: J. Proteome Res. 2007, 6, 4, 1615Publication Date (Web):March 7, 2007Publication History Published online7 March 2007Published inissue 1 April 2007https://pubs.acs.org/doi/10.1021/pr078005jhttps://doi.org/10.1021/pr078005jcorrectionACS PublicationsCopyright © 2007 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views265Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (43 KB) Get e-AlertscloseSUBJECTS:Cancer,Peptides and proteins,Plasma,Protein dynamics Get e-Alerts
Today's Engineering Heroes (2015)

Last July, IEEE Spectrum chall enged readers to identify today's unsung engineering heroes-those worthy engineers who are making a difference in the world and yet have not received the recognition they deserve. As author G. Pascal Zachary noted, engineering suffers from an unusual lack of heroes. "The hero deficit is...bad for engineering," he added, "because it diminishes the enterprise in the eyes of the public, and it constricts the flow of talent into the field."
Remaking the news: Essays on the future of journalism scholarship in the digital age (2018)

As editors Pablo Boczkowski and C. W. Anderson explain in the introduction to Remaking the News, this is a collection of essays “about the relationship between technology and journalism.” The “technology” is, of course, digital and the “journalism” is pretty much everything that digital technologies touch—both in production and circulation—across a vast landscape of computer-enabled reportage, from the trivial to the profound. What an ambitious undertaking! Yet the ambition is not misplaced. There is serious scholarship here, organized across four sections that embrace and interrogate broad categories: theory and methodology; key concepts; occupational culture and practice; and underexamined themes. Furthermore, unlike many collected works, Remaking the News does not suffer from inconsistency, wherein one or two disappointing contributions tend to spoil the effect of the whole. On the contrary, this is an extraordinarily even presentation where the reader can be assured of taking away something of value from each essay on offer. And should the trajectory of a section become somehow muddled there are helpful commentaries by senior scholars to help us resituate thematic purpose.
Designing planning and control interfaces to support user collaboration with flying robots (2017)

Robots are becoming increasingly prevalent and are already providing assistance in a variety of activities, ranging from space exploration to domestic housework. Recent advances in the design of sensors, motors, and microelectromechanical systems have enabled the development of a new class of small aerial robots. These free-flying robots hold great promise in assisting humans by acting as mobile sensor platforms to collect data in areas that are difficult to access or infeasible to instrument. In this work, we explored the design of interfaces that support users in working with free-flying robots to accomplish tasks including inventory logistics and management, environmental data collection, and visual inspection. Extending prior work in control interfaces for ground robots, we conducted a formative study in order to identify key design requirements for free-flyer interfaces. We designed several realistic tasks for use in evaluating human–robot interaction within the context of indoor free-flyer operation. We implemented three prototype interfaces that each provide varying degrees of support in enabling remote users to work with a flying robot to plan, communicate goals, accomplish tasks, and respond to changes in a dynamic environment. An experimental evaluation of each interface found that the interface designed to support collaborative planning and replanning using an interactive timeline and three-dimensional spatial waypoints significantly improved users’ efficiency in accomplishing tasks, their ability to intervene in response to spontaneous changes in task demands, and their ratings of the robot as a teammate compared to interfaces that support low-level teleoperation or waypoint-based supervisory control. Our results demonstrate the utility of a data-driven design process and show the need for free-flyer interfaces to consider planning phases in addition to task execution. In addition, we demonstrate the importance of providing interface support for interrupting robot operations as unplanned events arise.
Influence of target temperature on crystallization and properties of NiTi thin film shape memory alloy (2001)

A new process parameter viz.; target temperature, has been introduced to decrease the composition variables between the target and substrate. A DC magnetron sputtering system has been used for the deposition of NiTi film from equiatomic NiTi target on silicon substrate. The target transitions from a low temperature value to a high temperature value (&gt;700 degree(s)C) during sputtering. The sputtered films were crystallized by heating to 500 degree(s)C for 10 minutes in situ prior to removal from the sputtering system. X-ray diffractogram shows that the film peaks correspond to martensite as well as austenite phases. The film developed under this process displays the two-way shape memory effect without post annealing. Electrical resistivity measurement reveals that there are three different phases present viz.; austenite, rhombohedral and martensite, which exists at different temperature ranges. The characteristic transformation temperatures determined by the electrical resistivity method are compared with those obtained with DSC thermograms.
Highly electron rich alkyl- and dialkyl-N-pyrrolidinyl phosphines: an evaluation of their electronic and structural properties (2002)

Phosphines containing two N-bound pyrrolidine groups and one alkyl or aryl group have been prepared and shown to be unusually electron rich donor ligands when compared to either tris(N-pyrrolidinyl)phosphine or the trialkyl- or triaryl-phosphines. It is proposed that the electron donating ability of a pyrrolidine group towards phosphorus had been underestimated as only two pyrrolidinyl groups can donate towards the phosphine via the nitrogen lone pair. trans-L2Rh(CO)Cl complexes have been prepared from the phosphines and used to quantify the electron donor characteristics. Two of these complexes have been characterised by X-ray crystallography. The reaction of these phosphines with iron(II) complexes has also been studied. Platinum(II) complexes of the ligands have been prepared and also (in three examples) characterised by X-ray crystallography, which has enabled the steric and bonding properties to be evaluated. tert-Butyl(dipyrrolidinyl)phosphine is one of the most electron rich phosphines known. The dialkyl(pyrrolidinyl)phosphines have been found to contain less potent N→P donation, and are somewhat less good donor ligands.