gebhart/patrepeval huggingface dataset:
Using a Spectrophotometer to Evaluate the Spectral Power Distribution of Lamps for Poultry Production (2014)

Recently, the U.S. government has begun restricting the production of incandescent light bulbs. Many poultry houses use incandescent light bulbs; however, more energy efficient types of technology are required. This project is testing the spectral power distribution from a variety of alternative lighting technologies including light emitting diodes (LED) and cold cathode fluorescent lamps (CCFL). Three LED, two incandescent and one CCFL were tested using a StellarNet Spectrophotometer was used. Each bulb was placed within the instrument and the spectral power distribution was recorded at 10% increments from 100% down to 10%. There was a difference between dimmers and between technologies. The spectral power distributions of the incandescent bulbs (Sylvania and General Electric) followed the same trend except the General Electric lamp contained more peaks than the Sylvania. Three of LED lamps (Overdrive 6W, NextGen 12W and Evergreen 9W) were similar to each other, while the ONCE Agrishift LED lamp included different peaks than the others. The cold cathode fluorescent lamp contained spectra unlike the others with numerous peaks. Depending on the technology, the PLS-7200 MR3 and Pro-Tech 2K Green Rimmer dimmers seemed to be the most proportional when comparing intensity and percentage. The PLS-2000 MR4 was the least proportional when comparing intensity and percentage.
Terahertz time-domain imaging of “The Last Supper” (2020)

The terahertz time-domain imaging technique is applied to investigate the internal structure of “The Last Supper”, a masterpiece wall painting of Leonardo Da Vinci. The experimental results support the estimated internal structure based on previous studies by using fragment samples during the last conservation.
Redox-Mediator-Assisted Electrocatalytic Hydrogen Evolution from Water by a Molybdenum Sulfide-Functionalized Metal–Organic Framework (2018)

The Zr6-based metal–organic framework NU-1000 was successfully functionalized with candidate catalysts—MoSx units—via SIM (solvothermal deposition in MOFs) of molybdenum(VI), followed by reaction with H2S gas. The structure of the material, named MoSx-SIM, was characterized spectroscopically and through a single-crystal X-ray diffraction measurement. These measurements and others established that the catalyst is monometallic, with mixed oxygen and sulfur coordination, and that it forms from a MOF-node-supported molybdenum-based cluster featuring only oxy ligands. Notably, the formal potential for the MOF-grafted complex, like that for the metal–sulfur active site of hydrogenase, is nearly coincident with the formal potential for the hydrogen couple. Its effective concentration within the mesoporous MOF is several hundred millimolar, and its porous-framework-based immobilization/heterogenization obviates the need for aqueous solubility as a condition for use as a well-defined catalyst. MoSx-SIM was evaluated as an electrocatalyst for evolution of molecular hydrogen from aqueous acid. Although the MoSx-functionalized framework exhibits catalytic behavior, the highly insulating nature of the support inhibits high electrocatalytic performance. Introduction of an archetypal redox mediator (RM), methyl viologen (MV2+), resulted in more than 20-fold enhancement in its catalytic performance on a turnover frequency basis, implying efficient RM-assisted electron transfer to otherwise electrochemically non-addressable MoSx moieties. Electrochemical kinetic studies with additional viologens as mediators reveal an unexpected square-root dependence of overall reaction rate on mediator concentration, as well as sensitivity to the strength of RM•+ as a reductant. These observations, together with observations of potential-dependent H/D isotope effects and potential-dependent pH effects, provide useful insights into the catalysis mechanism and help to explain how the MOF-affixed monometallic catalyst can effectively catalyze a two-electron reduction reaction, i.e., hydrogen evolution from acidified water.
Predictive Value of Psychiatric History, Genital Pain and Menstrual Symptoms for Sexuality After Hysterectomy (1995)

Departments of Obstetrics and Gynecology, and Statistics, University of Uppsala, Uppsala; Department of Obstetrics and Gynecology, University Hospital of Uppsala and Umea, Umea, Sweden. Acta Obstet Gynecol Scand 1994;73:575-580
Electricalsteeringofvehicles-fault-tolerantanalysisanddesign (2006)

The topic of this paper is systems that need be designed such that no single fault can cause failure at the overall level. A methodology is presented for analysis and design of fault-tolerant architectures, where diagnosis and autonomous reconflguration can replace high cost triple redundancy solutions and still meet strict requirements to functional safety. The paper applies graph-based analysis of functional system structure to flnd a novel fault-tolerant architecture for an electrical steering where a dedicated AC-motor design and cheap voltage measurements ensure ability to detect all relevant faults. The paper shows how active control reconflguration can accommodate all critical faults and the fault-tolerant abilities are demonstrated on a warehouse truck hardware.
Morphology, Thermal and Mechanical Properties of Poly(propylene) Fibre‐Matrix Composites (2003)

Abstract Preparation and properties of poly(propylene)‐poly(propylene) composites have been investigated. Poly(propylene) fibres of varying diameter have been incorporated in a random ethylene co ‐poly(propylene). The composites prepared from the same semi‐crystalline polymer in the matrix and reinforcement have lead to inherently strong interfacial bonding between the two phases of the same polymer. The composites demonstrated enhanced stiffness, which increased with fibre diameter. The structure, thermal, static and mechanical properties of poly(propylene) long fibre reinforced random co ‐poly(propylene) composites have been studied with reference to the fibre diameter. The matrix and fibre components retained their separate melting temperatures. After melting, the two phases remained separate and showed their individual crystallization temperatures on cooling, and melting temperatures on a second heating. The melting temperature of the poly(propylene) fibres increased after formation of the composites. The compression molding of the composites at a temperature below the melting temperature of the fibres caused annealing of the fibre crystals. By incorporation of long poly(propylene) fibre into random co ‐poly(propylene), the glass transition, storage and static modulus have been found to be increasing and composite with the largest fibre diameter shows better properties. Transcrystallization of the matrix poly(propylene) was observed. Optical microscopy of composites with fibre diameter 68 μm. magnified image Optical microscopy of composites with fibre diameter 68 μm.
Super‐Resolution Detection of DNA Nanostructures Using a Nanopore (2023)

High-resolution analysis of biomolecules has brought unprecedented insights into fundamental biological processes and dramatically advanced biosensing. Notwithstanding the ongoing resolution revolution in electron microscopy and optical imaging, only a few methods are presently available for high-resolution analysis of unlabeled single molecules in their native states. Here, label-free electrical sensing of structured single molecules with a spatial resolution down to single-digit nanometers is demonstrated. Using a narrow solid-state nanopore, the passage of a series of nanostructures attached to a freely translocating DNA molecule is detected, resolving individual nanostructures placed as close as 6 nm apart and with a surface-to-surface gap distance of only 2 nm. Such super-resolution ability is attributed to the nanostructure-induced enhancement of the electric field at the tip of the nanopore. This work demonstrates a general approach to improving the resolution of single-molecule nanopore sensing and presents a critical advance towards label-free, high-resolution DNA sequence mapping, and digital information storage independent of molecular motors.
Composition, yield, texture and aroma compounds of goat cheeses as related to the A and O variants of αsl casein in milk (1998)

International audience
Technoeconomic Boundary Analysis of Biological Pathways to Hydrogen Production (2009)

Report documenting the biological and engineering characteristics of five algal and bacterial hydrogen production systems selected by DOE and NREL for evaluation.
PDBMine: A Reformulation of the Protein Data Bank to Facilitate Structural Data Mining (2019)

Large scale initiatives such as the Human Genome Project, Structural Genomics, and individual research teams have provided large deposits of genomic and proteomic data. The transfer of data to knowledge has become one of the existing challenges, which is a consequence of capturing data in databases that are optimally designed for archiving and not mining. In this research, we have targeted the Protein Databank (PDB) and demonstrated a transformation of its content, named PDBMine, that reduces storage space by an order of magnitude, and allows for powerful mining in relation to the topic of protein structure determination. We have demonstrated the utility of PDBMine in exploring the prevalence of dimeric and trimeric amino acid sequences and provided a mechanism of predicting protein structure.
Total synthesis of (.+-.)-ferruginol and (.+-.)-hinokione (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of (.+-.)-ferruginol and (.+-.)-hinokioneDavid L. Snitman, Richard J. Himmelsbach, and David S. WattCite this: J. Org. Chem. 1978, 43, 25, 4758–4762Publication Date (Print):December 1, 1978Publication History Published online1 May 2002Published inissue 1 December 1978https://pubs.acs.org/doi/10.1021/jo00419a011https://doi.org/10.1021/jo00419a011research-articleACS PublicationsRequest reuse permissionsArticle Views661Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Redistribution of microtubules in dendrites of hippocampal CA1 neurons after tetanic stimulation during long-term potentiation. (2008)

It is now well accepted that the trafficking of AMPA receptors to the postsynaptic plasma membrane plays an essential role in long-term potentiation at the hippocampal Schaffer collateral synapses on CA1 pyramidal cells, but the motor mechanism of trafficking is unknown. We suspected that this trafficking of AMPA receptors during long-term potentiation may be carried out along microtubules by their motors. To ascertain this hypothesis, we light- and electron-microscopically studied the distribution of microtubules in dendrites of CA1 neurons of non-stimulated and stimulated rat hippocampal slices by using very strong tetanic stimulation for inducing long-term potentiation. As a result, we observed the following changes: 1. In immunofluorescence for microtubules and IP3 receptor using ultrathin-cryosections, linear signals of microtubules in main dendritic shafts were changed into fragmented. 2. Many spotty signals of microtubules emerged at the peripheral area of dendrites. Electron-microscopically, there was redistribution of microtubules in dendritic spines and dendritic shafts, and the thickening of post-synaptic density. 3. Many microtubules concentrated to thickened postsynaptic density in spines and new ones emerged, going to spines from dendritic shafts. These results strongly suggest that new tracks of microtubules from cell bodies to the stimulated postsynaptic membranes were produced after tetanic stimulation during long-term potentiation. This newly produced microtubules between stimulated postsynaptic membranes and the cell body must be the most promising candidate of the track for the trafficking of AMPA receptors to the stimulated postsynaptic plasma membrane.
Supplementary Table 1 from Preclinical Evaluation of the WEE1 Inhibitor MK-1775 as Single-Agent Anticancer Therapy (2023)

&lt;p&gt;XLSX file - 155K, Proliferation assay EC50 results for MK-1775 in diverse tumor cell lines.&lt;/p&gt;
NFE2L2 synergizes with beta‐catenin gene mutations to induce HCC in patients and mice (2019)

Nrf/Keap signaling and Wnt/b‐catenin signaling are important in liver pathophysiology. Mutations in NFE2L2 (encoding for Nrf2) and CTNNB1 (encoding for beta‐catenin) can co‐occur in a subset of HCC patients. However, the precise relevance of these co‐occurrences remains obscure. In the current study, we explored the relevance of any cross‐talk between Nrf2 and Wnt signaling using the sleeping beauty transposon/transposase and hydrodynamic tail vein injection (HDTVI) to co‐express relevant mutant forms of CTNNB1 and NFE2L2 in murine livers. TCGA data showed that among the 377 HCC patients, there were 99 patients with CTNNB1 mutation, 15 patients with NFE2L2 mutation and 18 with mutations in KEAP1. 12 patients of the 377 cases had concomitant mutations in CTNNB1 and NFE2L2 or KEAP1, representing around 3% of all and 12% of CTNNB1 mutated cases. We next co‐expressed beta‐catenin‐T41A and NFE2L2‐WT or NFE2LE‐G3A1 or NFE2L2‐T80K in mouse livers, either individually or together. The NFE2L2‐WT:beta‐catenin‐T41A injected mice showed normal gross morphology and histology by H&amp;E test at 14‐weeks post injection. At this time, NFE2L2‐T80K:beta‐catenin‐T41A and NFE2L2‐G31A:beta‐catenin‐T41A groups develop HCC. HCC developed faster in the NFE2L2‐G31A:beta‐catenin‐T41A group versus the NFE2L2‐T80K:beta‐catenin‐T41A group. Several downstream target genes of Nrf2 were up‐regulated significantly in HCCs occurring in these models, including NAD(P)H dehydrogenase [quinone]1 (NQO1) and peroxiredoxin 1 (PRDX1), suggesting the mutations in NFE2L2 to be GOF. There was also an increase in activation of AKT, mTOR and ERK. Likewise, beta‐catenin targets such as GS were increased remarkably. Thus, we have a generated a highly relevant mouse model of HCC representing a subset of human HCC which is characterized by activation of both Nrf2 and Wnt signaling and hence will lend itself well for investigating biology and precision therapies. Support or Funding Information 1R01DK62277, 1R01DK100287,1R01CA204586 and Endowed Chair for Experimental Pathology (S.P.M.). This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
The 1.4 Å Crystal Structure of the Human Oxidized Low Density Lipoprotein Receptor Lox-1 (2005)

The lectin-like oxidized low density lipoprotein receptor-1 (Lox-1) mediates the recognition and internalization of oxidatively modified low density lipoprotein by vascular endothelial cells. This interaction results in a number of pro-atherogenic cellular responses that probably play a significant role in the pathology of atherosclerosis. The 1.4 angstrom crystal structure of the extracellular C-type lectin-like domain of human Lox-1 reveals a heart-shaped homodimer with a ridge of six basic amino acids extending diagonally across the apolar top of Lox-1, a central hydrophobic tunnel that extends through the entire molecule, and an electrostatically neutral patch of 12 charged residues that resides next to the tunnel at each opening. Based on the arrangement of critical binding residues on the Lox-1 structure, we propose a binding mode for the recognition of modified low density lipoprotein and other Lox-1 ligands.
Photocurrent measurements of electron traps on ITOX processed SIMOX structures (2002)

Photocurrent measurements have been performed on internal thermal oxide (ITOX) buried oxide (BOX) SIMOX structures. After electron injection, from a 5eV mercury light source, the net electron trapping per area for the ITOX structure was found to be larger than that of a control SIMOX structure. This increase has been attributed to the ITOX's process influence on the formation of the ITOX/BOX oxide.
Unique aggregation of conjugated amphotericin B and its interaction with lipid membranes (2016)

The purpose of this paper was to investigate the aggregation of amphotericin B (AMB) and AMB-arabinogalactan conjugate (AMB-AGC), and the interactions of these drugs with free and membrane-embedded sterols. Aggregation of AMB and AMB-AGC was studied by circular dichroic (CD) and UV absorbance spectroscopic techniques. The effect of liposomes on the spectra was utilized to investigate the interactions of aggregates with membrane-embedded sterols. Interaction with free sterols was studied by measuring sterols' effect on AMB/AMB-AGC susceptibility test. The results demonstrated that AMB-AGC forms unique aggregates in aqueous solution which differ from those formed by free AMB. Ergosterol and cholesterol embedded in liposomes, affected the CD spectra obtained for both AMB and AMB-AGC, indicating interactions of these sterols with both drugs. Interaction with both cholesterol and ergosterol resulted in an increase of AMB-AGC's minimal inhibitory concentration (MIC) in Candida albicans. In conclusion, AMB-AGC forms unique aggregates in aqueous solution; these aggregates interact with membrane-embedded cholesterol and ergosterol and with free sterols. These results indicate that the selectivity of AMB-AGC to fungal cells may not occur due to inability to bind cholesterol but probably as a result of this unique aggregation. Understanding this mechanism may help to develop a safer AMB formulation for therapy.
Laser Shock Peening: Toward the Use of Pliable Solid Polymers for Confinement (2019)

This paper presents the first extensive study of the performances of solid polymers used as confinement materials for laser shock applications such as laser shock peening (LSP) as opposed to the exclusively used water-confined regime up to now. The use of this new confinement approach allows the treatment of metal pieces needing fatigue behavior enhancement but located in areas which are sensitive to water. Accurate pressure determination in the polymer confinement regime was performed by coupling finite element simulation and experimental measurements of rear free-surface velocity using the velocity interferometer system for any reflector (VISAR). Pressure could reach 7.6 and 4.6 GPa for acrylate-based polymer and cross-linked polydimethylsiloxane (PDMS), respectively. At 7 and 4.7 GW/cm 2 , respectively, detrimental laser breakdown limited pressure for acrylate and PDMS. These results show that the pressures produced were also as high as in water confinement, attaining values allowing the treatment of all types of metals with LSP and laying the groundwork for future determination of the fatigue behavior exhibited by this type of treated materials.
962-P: Continuous Glucose Monitor Readings Lag Interstitial Glucose by Several Minutes (2019)

Objective: Continuous glucose monitor (CGM) measured glucose lags blood glucose by several minutes, and this delay is usually attributed to the latency of interstitial fluid. However, independent findings suggest that interstitial glucose dispersion is near-immediate. This study seeks to determine the physiological locus of CGM latency. Methods: Current was measured at 1 Hz in Dexcom G4 CGMs using a CHI 1440 potentiostat. CGMs were exposed to varying glucose levels in vitro to define sensor kinetics. Next, CGMs were implanted in mice, and sensor vs. blood glucose responses were measured following an intravenous glucose challenge. Finally, dispersion of a fluorescent glucose analogue (2-NBDG) into the CGM micro-environment was observed in vivo using intravital microscopy. Tissue deposited on sensors and non-CGM implanted subcutaneous fat were then collected for histological analysis. Results: The CGM time constant in vitro was 51±3 seconds. In vivo, CGMs took 24±7 minutes to reach a local maximum in maximum current following intravenous injection of glucose. 2-NBDG took 21±7 minutes to reach maximum fluorescence near the sensor, vs. 6±6 minutes in subcutaneous fat (p=0.0011). Collagen was increased in sensor deposits relative to non-CGM implanted subcutaneous fat (p=0.0018), and collagen content was correlated with 2-NBDG latency (R=0.96, p=0.0004). Conclusions: Interstitial glucose responds to changes in blood glucose within seconds, whereas the glucose levels seen by a CGM are delayed by several minutes due to fibrous encapsulation. A CGM that avoids encapsulation could approximate real-time blood glucose measurements. Additionally, these data raise the possibility that fibrosis underlies insulin resistance by creating a biophysical impediment to the interstitial dispersion of glucose. Disclosure P.M. McClatchey: None. E.S. McClain: None. I.M. Williams: None. J.M. Gregory: Consultant; Self; InClinica. D. Cliffel: None. D. Wasserman: None. Funding National Institutes of Health (DK059637, DK054902, DK050277, T32DK101003, F32DK120104); American Heart Association
An analysis of replacement and synonymous changes in the rodent L1 repeat family. (1986)

L1 is a family of long interspersed repetitive sequences in mammals that includes the BamHI family in rodents and the KpnI family in primates. Previous studies have shown that L1 repeats contain a long open reading frame and that the family evolves in concert. Working with 32 rodent elements for which DNA sequence is available, we used the distribution of replacement and synonymous changes to determine which L1 lineages had been expressing their reading frame. The evidence obtained is consistent with there having been a small number of L1 genes that have been expressing a functional protein. Much of the concerted evolution in L1 is accounted for by the tendency of these functioning L1 genes to continually create nonfunctional pseudogenes by reinsertion into the genome of sequences derived from their transcripts. The gain of new pseudogenes is balanced by the loss of old pseudogenes with a half-life of 2 Myr. Therefore, most of the observed L1 repeats are at a dead end with respect to either the expression of the L1 protein or the potential to elaborate further copies of themselves. However, the turnover of L1 pseudogenes is sufficient to constitute a vast flux of sequences into and then out of the flanking regions of all cellular genes. If the presence of flanking L1 pseudogenes affects the expression of other genes in even a subtle fashion, this process should represent a major source of genetic variation. A second level of concerted evolution occurs within the functional L1 sequences in a pattern that did not meet our expectations for selfish DNA. Also, in spite of the marked suppression of replacement relative to synonymous changes in functioning L1 genes, they evolve at an overall rate accelerated to the level of their own pseudogenes.
ChemInform Abstract: Cells Containing Solvated Electron Lithium Negative Electrodes. (1990)

Abstract The novel solvated electron lithium electrode, developed in order to improve the electrochemical reversibility in lithium based nonaqueous cells, consists of lithium initially dissolved in liq.