gebhart/patrepeval huggingface dataset:
Knochenmetastasierung beim Wilms-Tumor in Abhängigkeit vom histologischen Grading. Histologische und klinische Besonderheiten (1981)

86 patients with Wilms' tumor were treated in Heidelberg between 1951 and 1980. Using the histopathologic grading according to Hardwick and Stowens the sarcomatous tumor type has an unfavorable prognosis. All the patients in stage III to V developed metastases. In contrast to other types of Wilms' tumor these sarcomatous tumors do metastasize to bones, not primarily to the lung. Boys up to 5 years are mostly affected by the tumor. These were "cold" lesions in bone scan using different radionuclides on skeletal osteolytic metastases, which is limiting the application of scans to detect bone metastases in Wilms' tumor. A more aggressive chemotherapy should be given to improve prognosis of the sarcomatous type of Wilms' tumor.
[Safety depth of acupuncture at Yamen (GV 15) in patients with atlantoaxial dislocation]. (2019)

The safe depth of acupuncture at Yamen (GV 15) has significantly changed under AAD, so during the clinical acupuncture the needle insertion should be less than its safe depth.
Acyclovir therapy in neonatal herpes simplex virus infection (1982)

OFFIT, PAUL A. MD; STARR, STUART E. MD; ZOLNICK, PATRICIA AND; PLOTKIN, STANLEY A. MD Author Information
From Animals to Animats 10 (2008)

The Animals to Animats Conference brings together researchers from ethology, psychology, ecology, artificial intelligence, artificial life, robotics, engineering, and related fields to further understanding of the behaviors and underlying mechanisms that allow natural and synthetic agents (animats) to adapt and survive in uncertain environments. The work presented focuses on well-defined models--robotic, computer-simulation, and mathematical--that help to characterize and compare various organizational principles or architectures underlying adaptive behavior in both natural animals and animats.
Current-sensorless power-angle-based MPPT for single-stage grid-connected photovoltaic voltage-source inverters (2013)

This paper proposes a current-sensorless power-angle-based MPPT for single-stage grid-connected photovoltaic voltage-source inverters. The proposed tracker eliminates the use of the current sensor by using only the voltage sensor: The current sensor is substituted with a new quantity, which is the sine value of the power-angle (the phase angle between the inverter output voltage and the power grid voltage). A theoretical proof for this quantity is developed and is provided. Then, the proposed tracker is designed in MATLAB Simulink and implemented using a fixed-point DSP. Moreover, a breadboard has been built-up for testing the use of the proposed tracker with a single-stage grid-connected photovoltaic voltage-source inverter. Both of simulation and experimental results show that the proposed tracker attains a satisfactory performance. On the other hand, it requires a good control tool to accurately achieve the arithmetic calculations. A substantial part of the manufacturing cost and complexity burdens of MPPTs involves the use of current sensors. Considering this investigation saves cost, decreases complexity, and therefore increases the power density of the MPPTs.
The Energetics of Surfactant‐Templating of Zeolites (2018)

Mesoporosity can be conveniently introduced into zeolites by treating them in basic surfactant solutions. The apparent activation energy involved in the formation of mesopores in USY by surfactant-templating was determined using a combination of in situ synchrotron X-ray diffraction and ex situ gas adsorption. Additionally, techniques such as pH measurement and thermogravimetry/differential thermal analysis were employed to determine OH<sup>-</sup> evolution and cetyltrimethylammonium ion (CTA<sup>+</sup> ) uptake during the development of mesoporosity, thereby providing information about the different steps involved. The combination of both in situ and ex situ techniques has allowed determination of the apparent activation energies of the different processes involved in the mesostructuring of USY zeolites for the first time. Apparent activation energies are of the same order of magnitude (30-65 kJ mol<sup>-1</sup> ) as those involved in the crystallization of zeolites. Hence, important mechanistic insight into the surfactant-templating method was obtained.
Efficient Baseband Digital Predistorter Using Lut for Power Amplifier (PA) with Memory Effect (2014)

Modern communications systems will have to integrate multiple radio technologies to support a large number of wireless standards (WLAN, WPANâ¦). This system should operate with third generation (3G) air interface standards, where non constant envelope modulation formats (MQAM, OFDMâ¦) are required. The amplification of a modulated signal with large variation of envelope introduces distortions when the input-output characteristic is nonlinear. These distortions are particularly important when the power amplifier (PA) has non-linear memory effects with a wideband signal. The technique proposed in this paper aims to fight against this phenomenon by optimizing the method developed in the laboratory for a real-time implementation. This technique is able to provide exactly the reverse characteristics of a PA modeled by a Hammerstein model in base band. Its principle is to find the largest real root of a polynomial related to the analytical model of the PA and to the input signal to be amplified to calculate a pre-distorted signal. To reduce significantly the computation time, an implementation by the LUT method is proposed. This method uses two pre-distortion principles and can be implemented on a FPGA board with table bases method known for simplicity including in the same way the correction of the memory effect.
Dynamic Flash Memory with Dual Gate Surrounding Gate Transistor (SGT) (2021)

This paper proposes an ultra-scaled memory device, called `Dynamic Flash Memory (DFM)'. With a dual-gate Surrounding Gate Transistor (SGT), a capacitorless 4F <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> cell can be achieved. Similar to DRAM [1], refresh is needed, but high speed block refresh can improve the duty ratio. Analogous to Flash [2], three fundamental operations of “0” Erase, “1” Program, and Read are needed, but fast random read and page program are available. Through 2D TCAD simulation, the three basic operations for Dynamic Flash Memory have been qualitatively validated.
Enhancement of nonradiative interface recombination in GaAs coupled quantum wells (1990)

The recombination dynamics of GaAs multiple quantum wells as a function of barrier widths LB are studied in a semiconductor in the range between LB=0.87 nm (superlattice) and LB=18.1 nm (uncoupled wells) by means of cathodo- and photoluminescence. With decreasing LB the nonradiative recombination rate is found to be drastically enhanced, where-as the radiative recombination probability decreases. Thus a pronounced decrease of the quantum efficiency results. The controlled variation of the barrier width is found to be decisive for an unambiguous identification of the origin of the traps which are responsible for the nonradiative processes: Comparison with a theoretical calculation shows that they are localized at the heterointerfaces and not in the barriers.
The Extracellular Signal–Regulated Kinase Isoform ERK1 Is Specifically Required for In Vitro and In Vivo Adipogenesis (2005)

Hyperplasia of adipose tissue is critical for the development of obesity, but molecular mechanisms governing normal or pathological recruitment of new adipocytes remain unclear. The extracellular signal-regulated kinase (ERK) pathway plays a pivotal role in many essential cellular functions, such as proliferation and differentiation. Using ERK1(-/-) mice, we investigated the role of this isoform in adipose tissue development. Mice lacking ERK1 have decreased adiposity and fewer adipocytes than wild-type animals. Furthermore, ERK1(-/-) mice challenged with high-fat diet are resistant to obesity, are protected from insulin resistance, and have a higher postprandial metabolic rate. To get insights into cellular mechanisms implicated in reduced adiposity in ERK1(-/-) animals, we analyzed adipocyte differentiation in ERK1(-/-) cells. Compared with wild-type control cells, mouse embryo fibroblasts and cultures of adult preadipocytes isolated from ERK1(-/-) adult animals exhibit impaired adipogenesis. An inhibitor of the ERK pathway does not affect the residual adipogenesis of the ERK1(-/-) cells, suggesting that ERK2 is not implicated in adipocyte differentiation. Our results clearly link ERK1 to the regulation of adipocyte differentiation, adiposity, and high-fat diet-induced obesity. This suggests that a therapeutic approach of obesity targeting specifically the ERK1 isoform and not ERK2 would be of particular interest.
Structural versatility of peptides from C.alpha.,.alpha.-dialkylated glycines. A conformational energy computation and x-ray diffraction study of homopeptides from 1-aminocyclohexane-1-carboxylic acid1 (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStructural versatility of peptides from C.alpha.,.alpha.-dialkylated glycines. A conformational energy computation and x-ray diffraction study of homopeptides from 1-aminocyclohexane-1-carboxylic acid1V. Pavone, E. Benedetti, V. Barone, B. Di Blasio, F. Lelj, C. Pedone, A. Santini, M. Crisma, G. M. Bonora, and C. TonioloCite this: Macromolecules 1988, 21, 7, 2064–2070Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ma00185a031https://doi.org/10.1021/ma00185a031research-articleACS PublicationsRequest reuse permissionsArticle Views60Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Detection of Air Leakage in Building Envelopes Using Ultrasound Technology (2019)

Heating energy represents a significant proportion of the total energy consumption of theFederal Republic of Germany. Thus, a reduction of heating energy demand in buildings is one of the central points of German energy saving and climate goals. Considering that the current rate of new building construction is approximately 1 %, the most significant energy saving potential lies in existing buildings. The analysis of existing buildings will thus become more important in the years to come. As a result, the development of new measurement systems to assess the need for renovation is required. In this context, detailed Information about heat insulation and airtightness is essential. The current approaches to detect air leakage in building envelopes are mostly time consuming and expensive. Therefore, the development of an advanced and more inexpensive method is a vital step. In this paper, we2 present a study about the feasibility and suitability of ultrasound technology to evaluate the size of air leakages in building envelopes. The advantage of ultrasound technology is that the corresponding wavelengths are small enough to penetrate small openings and that disturbing background noise is usually low. Moreover, the frequencies are above the human threshold of hearing; hence, working and living inside the building would be affected less by the measurement than by a blower door test or leakage detection with audible sound. To examine the suitability of this technology, we use an experimental setup of ultrasound microphones and a speaker in a test chamber. Within this setup, we measured different hole sizes and assessed whether they could be detected using ultrasonic frequency swept signals.
4‐Hydroxyderricin, as a PPARγ Agonist, Promotes Adipogenesis, Adiponectin Secretion, and Glucose Uptake in 3T3‐L1 Cells (2016)

Adipocyte differentiation plays a pivotal role in maintaining the production of small-size adipocytes with insulin sensitivity, and impaired adipogenesis is implicated in insulin resistance. 4-Hydroxyderricin (4-HD), a phytochemical component of Angelica keiskei, possesses diverse biological properties such as anti-inflammatory, antidiabetic, and antitumor. In the present study, we investigated the effects of 4-HD on adipocyte differentiation. 4-HD promoted lipid accumulation in 3T3-L1 cells, upregulated both peroxisome proliferator-activated receptor (PPAR)-γ mRNA and protein expression, and acted as a ligand for PPARγ in the luciferase assay. Moreover, 4-HD increased the mRNA and protein expression levels of adiponectin. Additionally, it promoted insulin-dependent glucose uptake into 3T3-L1 adipocytes and increased Akt phosphorylation and glucose transporter (GLUT) 4 mRNA expression. In summary, these findings suggest that 4-HD, which promoted adipogenesis and insulin sensitivity in 3T3-L1 cells, might be a phytochemical with potent insulin-sensitizing effects.
A modular architecture for formation control (2003)

We present a four layer architecture for coordinating a team of mobile robots equipped with range sensors and wireless network cards, and the task of navigating to a desired location in a desired formation. We develop graph-based algorithms for discovery, and cooperative control. Discovery involves the use of sensory information to organize the robots into a mobile network allowing each robot to establish its neighbors and, when necessary, one or more leaders. Cooperative control is the task of achieving a desired formation shape and maintaining it. In addition, we integrate a modular adaptive controller into our framework to explicitly deal with the unknown dynamics of the vehicles information. Numerical simulations illustrate the application of these ideas and demonstrate the scalability of the proposed architecture for a large group of robots.
Distribution of Irinotecan in Liver and a Human Tumor Xenograft Model by Tissue Imaging Mass Spectrometry (2012)

Nude mice with transplanted human head andneck tumors were treated with either irinotecan, methyl-selenocysteine (MSC), both drugs in combination, or non-treated (control). Frozen tumors and livers were sliced to~12 µm thick and thaw-mounted on to non-conductiveglass slides. Irinotecan metabolites were investigated bySingle Reaction Monitoring or CRM with an LTQ XLcoupled to a MALDI source.
Publisher’s Note: Measurement of the inclusive jet cross section using the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>k</mml:mi><mml:mi>T</mml:mi></mml:msub></mml:math>algorithm in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>p</mml:mi><mml:mover accent="true"><mml:mi>p</mml:mi><mml:mo>¯</mml:mo></mml:mover></mml:math>collisions at<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>1.96</mml:mn><mml:mtext> </mml:mtext><mml:mtext> </mml:mtext><mml:mi>TeV</mml:mi></mml:math>with the CDF II detector [Phys. Rev. D<b>75</b>, 092006 (2007)] (2007)

The authors report on measurements of the inclusive jet production cross section as a function of the jet transverse momentum in p{bar p} collisions at {radical}s = 1.96 TeV, using the k{sub T} algorithm and a data sample corresponding to 1.0 fb{sup -1} collected with the Collider Detector at Fermilab in Run II. The measurements are carried out in five different jet rapidity regions with |y{sup jet}| &lt; 2.1 and transverse momentum in the range 54 &lt; p{sub T}{sup jet} &lt; 700 GeV/c. Next-to-leading order perturbative QCD predictions are in good agreement with the measured cross sections.
Model-based condition monitoring at the wheel–rail interface (2008)

The dynamics of a rail vehicle is driven by the interaction between the wheel and rail. Any change to, for example, the shape of the wheel-rail profile or the contact adhesion conditions will change the response of the vehicle. The condition monitoring challenge is to interpret these changes into useful condition information. This paper presents the ongoing research into model-based condition monitoring at the wheel-rail interface applied to two applications: (i) wheel-rail profile estimation; and (ii) low adhesion detection. The wheel-rail profile estimation was carried out on a linearised simulation model that included a nonlinear conicity function. This function could be successfully estimated by also estimating the lateral track irregularities and giving the Kalman Filter self-updating information about the shape of the conicity function. The low adhesion detection was carried out on a complex nonlinear half vehicle model that included saturating contact force equations. The contact forces could be estimated by considering the half vehicle floating on a set of contact forces. Low adhesion conditions can be implied by the relative magnitudes of these contact forces.
Whole metabolome profiling identifies the combination of an eicosanoid, a bile acid and an androgen as a highly accurate marker of liver fibrosis in patients with non-alcoholic fatty liver disease (2019)

Non-alcoholic fatty liver disease (NAFLD) is among the most frequent causes of liver disease and estimates based on imaging and biopsy studies suggest that about 20 – 30% of adults in the United States and Europe have excess hepatic fat accumulation, and are at risk of developing progressive fibrosis, end-stage liver disease or hepatocellular carcinoma. Liver biopsy is considered the gold standard in the diagnostic evaluation of patients with suspected NAFLD, and fibrosis at index biopsy identifies those at risk of progression. However, liver biopsy is uncomfortable, more expensive than most non-invasive tools and carries a procedure-related risk which together renders it unsuitable for regular screening. This study aims to identify novel non-invasive markers by metabolite profiling that correlate with histological key lesions of progressive NAFLD.
Polymorphic markers of the glycogen debranching enzyme gene allowing linkage analysis in families with glycogen storage disease type III. (1997)

Glycogen storage disease type III (GSD-III), an autosomal recessive disease, is caused by deficient glycogen debranching enzyme (GDE) activity. We identified three polymorphic markers in the GDE gene using single strand conformation polymorphism (SSCP) analysis and DNA sequencing. They were -10G/A in the 5' non-translated region of exon 3,2001 + 8C/T in intron 16, and 3199C/T (P1067S) in exon 25. Two polymorphic markers (-10G/A and 2001 + 8C/T) were highly informative in both controls and GSD-III patients with heterozygosity values of 0.50 and 0.46, respectively. The third marker (3199C/T) had a heterozygosity value of 0.26. Restriction analysis of the PCR amplified genomic DNA products in two GSD-III families showed for the first time the potential use of these markers for carrier detection and prenatal diagnosis in this disease.
Tri-2-Hydroxyarachidonein Induces Cytocidal Autophagy in Pancreatic Ductal Adenocarcinoma Cancer Cell Models (2022)

Cell proliferation in pancreatic cancer is determined by a complex network of signaling pathways. Despite the extensive understanding of these protein-mediated signaling processes, there are no significant drug discoveries that could considerably improve a patient's survival. However, the recent understanding of lipid-mediated signaling gives a new perspective on the control of the physiological state of pancreatic cells. Lipid signaling plays a major role in the induction of cytocidal autophagy and can be exploited using synthetic lipids to induce cell death in pancreatic cancer cells. In this work, we studied the activity of a synthetic lipid, tri-2-hydroxyarachidonein (TGM4), which is a triacylglycerol mimetic that contains three acyl moieties with four double bonds each, on cellular and <i>in vivo</i> models of pancreatic cancer. We demonstrated that TGM4 inhibited proliferation of Mia-PaCa-2 (human pancreatic carcinoma) and PANC-1 (human pancreatic carcinoma of ductal cells) in <i>in vitro</i> models and in an <i>in vivo</i> xenograft model of Mia-PaCa-2 cells. <i>In vitro</i> studies demonstrated that TGM4 induced cell growth inhibition paralleled with an increased expression of PARP and CHOP proteins together with the presence of sub-G<sub>0</sub> cell cycle events, indicating cell death. This cytocidal effect was associated with elevated ER stress or autophagy markers such as BIP, LC3B, and DHFR. In addition, TGM4 activated peroxisome proliferator-activated receptor gamma (PPAR-γ), which induced elevated levels of p-AKT and downregulation of p-c-Jun. We conclude that TGM4 induced pancreatic cell death by activation of cytocidal autophagy. This work highlights the importance of lipid signaling in cancer and the use of synthetic lipid structures as novel and potential approaches to treat pancreatic cancer and other neoplasias.
Polarized Raman scattering and localized embedded strain in self-organized Si/Ge nanostructures (2003)

Using polarized Raman spectroscopy, we examine different vibrational modes (i.e., Si–Si, Si–Ge, and Ge–Ge) in Si/Ge self-organized nanostructures. Here, we present unambiguous proof that multilayers of Ge nanometer-size, “dome-shaped” islands grown on a 〈100〉 Si substrate are nearly fully relaxed and that the built-in strain field is substantially localized in the surrounding Si matrix. In contrast, multilayers with “pyramid-shaped” islands do not show observable relaxation. The large strain in the Si layers of the multilayer dome samples correlates with the greater self-organization in these structures compared to the multilayer pyramid samples.
Ultrafast all-optical modulation in silicon-based nanoplasmonic devices (2009)

A five-layer silicon-based nanoplasmonic waveguiding structure is proposed for ultrafast all-optical modulation and switching applications. Ultrafast nonlinear phase and amplitude modulation is achieved via photo-generated free carrier dynamics in ion-implanted silicon using above-bandgap femtosecond pump pulses. Both an analytical model and rigorous numerical simulations of the structures have shown that a switching time of 5 ps and an on-off contrast of 35 dB can be achieved in these devices.
Predictive Temperature-Aware DVFS (2009)

In this paper, we propose predictive temperature-aware dynamic voltage and frequency scaling (DVFS) using the performance counters that are already embedded in commercial microprocessors. By using the performance counters and simple regression analysis, we can predict the localized temperature and efficiently scale the voltage/frequency. When localized thermal problems that were not detected by thermal sensors are found after layout (or fabrication), the thermal problems can be avoided by the proposed software solution without delaying time-to-market. The evaluation results show that in a Linux-based laptop with the Intel Core2 Duo processor, DVFS using the performance counters performs comparable to DVFS using the thermal sensor.