gebhart/patrepeval huggingface dataset:
Transplantable immunoglobulin-secreting tumors in rats. VI. N-terminal sequence variability in LOU/C/Wsl rat monoclonal heavy chains. (1975)

Parametric roll is one of the research topics in the maritime industry. Due to longitudinal\nwaves, this phenomenon will cause explosive increase in a ships roll motion.\nThis large roll oscillations may lead to dangerous situations for the ship,\ncargo, crew and passengers. It can even lead to capsizing of the ship and results\nin damages into millions of Euro’s. Therefore parametric roll in ships need to be\navoided.\nTo determine if an avoidance system needs to be activated, nowadays the roll angle\nof the ship is measured. When this angle exceeds a certain value, the avoidance\nsystem will be switched on. If this occurs the ship already has a quite large roll angle.\nParametric roll occurs under different conditions of the environment and ship.\nOne of these conditions is that the natural roll period of the ship is twice the period\nof the waves observed from the ship (encounter frequency). So if the encounter\nfrequency can be estimated, it also can be predicted when parametric roll appears.\nFirst a small literature study to parametric roll is done. Then, in order to "‘detune"’\nthe roll condition, a dynamical speed controller is described. As a result of\nthat a surge-roll model is considered. After that, the encounter frequency is estimated\nby using an identification algorithm that combines the least square method\nwith a matrix forgetting factor algorithm. The model is further implemented in an\nelectro mechanical system in order to experimentally validate the effectiveness of\nthe controller.\nThe method to estimate the encounter frequency did not work out as expected.\nYet the proposed estimation algorithm wasn’t suitable, the average of the estimated\n!e signal seemed to variate around the expected value. On the other hand the dynamic\nvelocity controller was tested in the experimental setup. The controller now\nwasn’t activated when the encounter frequency reached a critical level, but at a critical\nroll angle of the ship. Slowing down the ship seemed to be a possibility to avoid\nparametric roll. But there the question occurs if one wants to take into account the\neconomic disadvantages of nearly coming to stand still. More research to combine\nspeed adjustment and avoidance mechanisms need to be done.
Open-world Instance Segmentation: Top-down Learning with Bottom-up Supervision (2023)

Many top-down architectures for instance segmentation achieve significant success when trained and tested on pre-defined closed-world taxonomy. However, when deployed in the open world, they exhibit notable bias towards seen classes and suffer from significant performance drop. In this work, we propose a novel approach for open world instance segmentation called bottom-Up and top-Down Open-world Segmentation (UDOS) that combines classical bottom-up segmentation algorithms within a top-down learning framework. UDOS first predicts parts of objects using a top-down network trained with weak supervision from bottom-up segmentations. The bottom-up segmentations are class-agnostic and do not overfit to specific taxonomies. The part-masks are then fed into affinity-based grouping and refinement modules to predict robust instance-level segmentations. UDOS enjoys both the speed and efficiency from the top-down architectures and the generalization ability to unseen categories from bottom-up supervision. We validate the strengths of UDOS on multiple cross-category as well as cross-dataset transfer tasks from 5 challenging datasets including MS-COCO, LVIS, ADE20k, UVO and OpenImages, achieving significant improvements over state-of-the-art across the board. Our code and models are available on our project page.
Nanohole formation by FIB and its application to biomolecular sensors (2002)

Rapid, reliable, and inexpensive characterisation of biomolecules, particularly nucleic acids and proteins, has become increasingly important. Among the current sensors, engineered transmembrane protein pores have been advantageous candidates for sensing elements. This sensor has two electrolyte-filled pools, which are separated by a lipid bilayer having a protein pore (e.g. /spl alpha/-hemolysin). The specimen molecules place in one of the pools can stochastically pass via the pore. They produce a fluctuating binary response in the transmembrane ionic current (Bezrukov et al, 1994; Li-Qun Gu et al, 1999). Instead of the protein pore, we have proposed use of nanometer-sized holes in a SiN/sub x/ membrane as a sensor head. We have fabricated the biomolecular sensor with nanoholes using a Si bulk micromachining technique (Fertig et al, 2000) and observed the ionic current via nanoholes. Through-nanoholes are formed by FIB (focused ion beam) (Yamaguchi et al, 1985; Gierak et al, 1997).
The Contribution of Salvador Moncada to Our Understanding of the Biology of Nitric Oxide (2003)

The observation, by Furchgott and Zawadzki, that a factor of short average life, released by endothelial cells accounted for vasodilation was the beginning of one of the most fascinating adventures in the recent history of science. The discovery that this released factor was nitric oxide had tremendous implications for our understanding not only of the homeostasis of the vascular tissue, but also of a variety of other biological processes ranging from synaptic plasticity to regulation of immune responses. This review article will lead the reader through the landmark events in this adventure, highlighting the fundamental role played by Salvador Moncada and his team.
Previous Preterm Cesarean Delivery and Risk of Subsequent Uterine Rupture (2008)

Women who have had a previous preterm cesarean delivery are at a minimally increased risk for uterine rupture in a subsequent pregnancy when compared with women who have had previous term cesarean deliveries.
Supplementary Table 2 from MLN0905, a Small-Molecule &lt;i&gt;PLK1&lt;/i&gt; Inhibitor, Induces Antitumor Responses in Human Models of Diffuse Large B-cell Lymphoma (2023)

&lt;p&gt;PDF file, 48KB, Plasma and OCI LY-19-Luc tumor pharmacokinetic parameters following a single oral dose of MLN0905 in CB-17 SCID mice.&lt;/p&gt;
Erratum: Oestreicher and elastography [J. Acoust. Soc. Am. <b>138</b>, 2317–2325 (2015)] (2018)

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&lt;title&gt;Perceived lightness difference with regard to spatial frequency and amplitude modulation&lt;/title&gt; (2000)

It has been found that the L* function defined in the CIELAB color space is not suitable to predict the human visual perception of modulated patterns at high spatial frequencies. For example, in multilevel halftoning (multitoning), when output levels are equally spaced in L*, it has been observed that the visibility of the resulting multitone patterns is not uniform across different parts of the tone scale. This leads to the hypothesis that the CIE L* function may not be a good metric to evaluate the perceived lightness differences at high-spatial frequencies as it was derived based on the perception of large area uniform patches. To investigate the relationship between suprathreshold lightness difference perception with regard to spatial frequency and amplitude modulation, we designed a psychophysical experiment, which was conducted using a lightness difference matching paradigm. The stimuli used in the experiment were horizontal square-wave gratings. The behavior of lightness difference perception under varying spatial frequencies and modulation amplitudes across the entire L* scale was studied. Consistent results were acquired that show a significant frequency-dependent effect where the effective lightness difference for high- frequency patterns is reduced for low L* values. The magnitude of this effect was found to be highly related to the spatial frequency of the modulation. Based on these results, we derived an effective lightness function that is dependent on spatial frequency. The effective lightness function can be applied to the selection of the output levels for multitoning.
A case of orbital and palpebral emphysema following fracture of the orbital floor. (2000)

A case of orbital and palpebral emphysema caused by fracture of the orbital floor is presented. The patient was a 4-year-old boy. He fell from a slide and struck the left side of his face. The patient presented with swelling of the left lower eyelid. A computed tomographic scan revealed a low density area inthe orbit and under the skin of the lower eyelid. Although mild exophthalmusand upward esodeviation ofthe eyeball had been caused by left orbital emphysema, no disorder of ocular movement was observed, andocular tension was normal. We administered antibiotics for 5 days to prevent infection and observed thepatient's grogress, giving instructions not to sneeze or blow his nose. Subsequent progress was favorable, and the swelling of the lower eyelid disappeared on the 7 th day after the injury. A computed tomographicscan obtained in the third week showed no remaining gas.
A clinician's guide to CAMBRA: a simple approach. (2009)

Caries risk assessment identifies those factors that are pathologic and suggests ways an astute clinician can implement protective strategies that can prevent progression and/or return the patient to health. Caries management by risk assessment (CAMBRA) focuses on treating and preventing the cause of the disease at an early stage, rather than waiting until it causes damage to tooth structure. This article summarizes and simplifies information previously published about CAMBRA implementation from the perspective of today's practicing clinician. The most recent science on prevention, remineralization, antimicrobials, and pH, as well as the use of fluoride, xylitol, and casein phosphopeptide-amorphous calcium phosphate (CCP-ACP) is also discussed.
THE IN VIVO CYTOTOXIC T CELL RESPONSE TO ALLOANTIGEN REQUIRES A Lyt-1+ HELPER T LYMPHOCYTE (1981)

Previous evidence has shown that Lyt-1+ helper T cells are required for an in vitro cytotoxic T cell response. We now present evidence which demonstrates an in vivo requirement for Lyt-1+ helper T cells in the activation of a killer T cell response. An adoptive transfer system was designed in which alloantigen-primed parental helper cells were transferred to an F1 recipient. After 1 day, this recipient of primed helper cells was lethally irradiated and normal responder spleen cells syngeneic to the primed helper cells were injected into the F1 recipient. In these experiments the semiallogeneic cells of the irradiated F1 mouse serve as the source of stimulator cells. When responder cells and irradiated helper cells were both present in the F1 mouse, good cytotoxic T cell responses were obtained. When either responders alone or helpers alone were examined, cytotoxic T cell responses were much lower. The presence in vivo of suppressor cells which inhibit cytotoxic T cell responses made it necessary to culture spleen cells from these irradiated recipients for short periods in vitro to reveal the cytotoxic T cells which had been generated in vivo. Cell collaboration was shown to occur before this in vitro culture period commenced; the generation of cytotoxicity required that helper cells and killer cell precursors interact in vivo. Treatment of the primed helper cells with anti-Thy-1 serum plus complement or anti-Lyt-1+ serum and complement removed helper cell activity. This indicates that the primed helper cell in in vivo collaboration is a Lyt-1+ T lymphocyte.
A Volume Rendering Algorithm Using an Analytic Approach for Curvilinear Volumes (1999)

A new approach is presented to visualize curvilinear volume data produced using the CFD or FEM Methods. Ray casting methods are effective and renders images with good quality. However, these methods suffer from a tremendous number of computations and can not deal with the curvilinear volume efficiently. The marching cubes method is a popular approach when the ambiguity problem reduces the reliability of the rendered image. We propose a new method to solve these problems. Our method is a cell-by-cell process which constructs sosurfaces using trilinear functions. Several speed up techniques are proposed to reduce the number of computations in our algorithm. In addition to this, error analysis and error minimization are also discussed. Our method is also easy to implement parallelized.
Cyclodextrin-Enabled Polymer Composites for Packaging (2018)

Cyclodextrin complexes of fragrances, antimicrobial agents, dyes, insecticides, UV-filters can be incorporated into polymers (packaging films, trays, containers) either to ensure the slow release or a homogeneous distribution of the complexed substances. This way the propagation of microorganisms on surface of enwrapped products is decelerated, or the product is made more attractive by slowly released fragrances, protected against UV-light-induced deterioration, oxidation, etc. Incorporating empty cyclodextrins into the packaging material an aroma barrier packaging is produced, which decelerates the loss of the aroma from the packaged food, prevents the penetration of undesired volatile pollutants from the environment, like components of exhaust gases, cigarette smoke, and reduces the migration of plasticizers, residual solvents and monomers, etc. Applying cyclodextrins in active packaging allows to preserve the quality of food and ensures a longer shelf-life for the packaged items.
Supplementary Figures 1 - 6 from Collagen Signaling Enhances Tumor Progression after Anti-VEGF Therapy in a Murine Model of Pancreatic Ductal Adenocarcinoma (2023)

&lt;p&gt;PDF file - 2694K, Supplementary Figure 1: Characterization of tumor growth in KIC mice (LSL-KrasG12D; Cdkn2alox/lox; p48Cre). Supplementary Figure 2: Liver metastatic burden in KIC mice. Supplementary Figure 3: Level of hypoxia, collagen I, Hif1alpha, and Hexokinase II in tumors from mice treated with mcr84 or mcr84 plus Gem. Supplementary Figure 4: Anti-TGFbeta inhibits mcr84-induced collagen deposition. Supplementary Figure 5: PDA cells express collagen receptors and Sparc. Supplementary Figure 6: Peak1 activation by collagen is sensitive to Ddr1 blockade.&lt;/p&gt;
Decoding of generic mental representations from functional MRI data using word embeddings (2016)

Abstract Several different groups have demonstrated the feasibility of building forward models of functional MRI data in response to concrete stimuli such as pictures or video, and of using these models to decode or reconstruct stimuli shown while acquiring test fMRI data. In this paper, we introduce an approach for building forward models of conceptual stimuli, concrete or abstract, and for using these models to carry out decoding of semantic information from new imaging data. We show that this approach generalizes to topics not seen in training, and provides a straightforward path to decoding from more complex stimuli such as sentences or paragraphs.
Epoxidation of the Commercially Relevant Divinylbenzene with [<i>tetrakis</i>-(Pentafluorophenyl)porphyrinato]iron(III) Chloride and Its Derivatives (2014)

Fluorinated Fe-porphyrins, especially [tetrakis(pentafluorophenyl)porphyrinato]iron(III) chloride (tetrakis(pentafluorophenyl)porphyrinato = TPFPP) (TPFPP)FeCl (Fepor-2a), were found to be highly efficient for catalyzing the double epoxidation of divinylbenzene (DVB) to divinylbenzene dioxide (DVBDO), a novel component of epoxy resin formulation. The electronic properties of the catalysts are highly dependent on the substituents on the phenyl groups of these metalloporphyrins. The electron-rich fluorinated Fe-porphyrins are more selective toward epoxidation but are more vulnerable toward decomposition in H2O2. On the other hand, the electron deficient Fe-porphyrins are more stable, yet more Lewis acidic, which facilitates the formation of byproducts such as epoxide ring opening and overoxidation.
An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for &lt;em&gt;in vivo&lt;/em&gt; Tumor Imaging and Monitoring of Tumor Immune Responses (2010)

Background: Ovarian cancer is generally diagnosed at an advanced stage where the case/fatality ratio is high and thus remains the most lethal of all gynecologic malignancies among US women 1,2,3. Serous tumors are the most widespread forms of ovarian cancer and 4,5 the Tg-MISIIR-TAg transgenic represents the only mouse model that spontaneously develops this type of tumors. Tg-MISIIR-TAg mice express SV40 transforming region under control of the Mullerian Inhibitory Substance type II Receptor (MISIIR) gene promoter 6. Additional transgenic lines have been identified that express the SV40 TAg transgene, but do not develop ovarian tumors. Non-tumor prone mice exhibit typical lifespan for C57Bl/6 mice and are fertile. These mice can be used as syngeneic allograft recipients for tumor cells isolated from Tg-MISIIR-TAg-DR26 mice. Objective: Although tumor imaging is possible 7, early detection of deep tumors is challenging in small living animals. To enable preclinical studies in an immunologically intact animal model for serous ovarian cancer, we describe a syngeneic mouse model for this type of ovarian cancer that permits in vivo imaging, studies of the tumor microenvironment and tumor immune responses. Methods: We first derived a TAg+ mouse cancer cell line (MOV1) from a spontaneous ovarian tumor harvested in a 26 week-old DR26 Tg-MISIIR-TAg female. Then, we stably transduced MOV1 cells with TurboFP635 Lentivirus mammalian vector that encodes Katushka, a far-red mutant of the red fluorescent protein from sea anemone Entacmaea quadricolor with excitation/emission maxima at 588/635 nm 8,9,10. We orthotopically implanted MOV1Kat in the ovary 11,12,13,14 of non-tumor prone Tg-MISIIR-TAg female mice. Tumor progression was followed by in vivo optical imaging and tumor microenvironment was analyzed by immunohistochemistry. Results: Orthotopically implanted MOV1Kat cells developed serous ovarian tumors. MOV1Kat tumors could be visualized by in vivo imaging up to three weeks after implantation (fig. 1) and were infiltrated with leukocytes, as observed in human ovarian cancers 15 (fig. 2). Conclusions: We describe an orthotopic model of ovarian cancer suitable for in vivo imaging of early tumors due to the high pH-stability and photostability of Katushka in deep tissues. We propose the use of this novel syngeneic model of serous ovarian cancer for in vivo imaging studies and monitoring of tumor immune responses and immunotherapies.
Drug-induced aseptic meningitis (2023)

Drug-induced aseptic meningitis is a rare but serious condition that should be suspected in patients with meningitis who test negative for a microbiological agent. The medical history is presented here of a woman with recurrent urinary tract infections where meningitis symptoms arose after repeated exposure to a frequently prescribed drug.
Data from A Pilot Trial of the Combination of Transgenic NY-ESO-1–reactive Adoptive Cellular Therapy with Dendritic Cell Vaccination with or without Ipilimumab (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Transgenic adoptive cell therapy (ACT) targeting the tumor antigen NY-ESO-1 can be effective for the treatment of sarcoma and melanoma. Preclinical models have shown that this therapy can be improved with the addition of dendritic cell (DC) vaccination and immune checkpoint blockade. We studied the safety, feasibility, and antitumor efficacy of transgenic ACT with DC vaccination, with and without CTLA-4 blockade with ipilimumab.&lt;/p&gt;Patients and Methods:&lt;p&gt;Freshly prepared autologous NY-ESO-1–specific T-cell receptor (TCR) transgenic lymphocytes were adoptively transferred together with NY-ESO-1 peptide-pulsed DC vaccination in HLA-A2.1–positive subjects alone (ESO, NCT02070406) or with ipilimumab (INY, NCT01697527) in patients with advanced sarcoma or melanoma.&lt;/p&gt;Results:&lt;p&gt;Six patients were enrolled in the ESO cohort, and four were enrolled in the INY cohort. Four out of six patients treated per ESO (66%), and two out of four patients treated per INY (50%) displayed evidence of tumor regression. Peripheral blood reconstitution with NY-ESO-1–specific T cells peaked within 2 weeks of ACT, indicating rapid &lt;i&gt;in vivo&lt;/i&gt; expansion. Tracking of transgenic T cells to the tumor sites was demonstrated in on-treatment biopsies via TCR sequencing. Multiparametric mass cytometry of transgenic cells demonstrated shifting of transgenic cells from memory phenotypes to more terminally differentiated effector phenotypes over time.&lt;/p&gt;Conclusions:&lt;p&gt;ACT of fresh NY-ESO-1 transgenic T cells prepared via a short &lt;i&gt;ex vivo&lt;/i&gt; protocol and given with DC vaccination, with or without ipilimumab, is feasible and results in transient antitumor activity, with no apparent clinical benefit of the addition of ipilimumab. Improvements are needed to maintain tumor responses.&lt;/p&gt;&lt;/div&gt;
Combining EEG and fMRI in Epilepsy: Methodological Challenges and Clinical Results (2004)

It is now possible to combine continuous recording of the EEG and continuous functional MRI scanning. This makes it possible to determine the regions of the brain showing changes in the fMRI signal in response to epileptic spikes occurring in the EEG. This article reviews the experience with this method in more than 100 studies performed over the last 4 years at the Montreal Neurological Institute. The technique is complex, and the authors review the various issues related to obtaining a good-quality EEG in the hostile environment of the magnetic resonance scanner, the statistical analysis of magnetic resonance images, in particular the issue of knowing what is the hemodynamic response function appropriate for the analysis of epileptic spikes, and the combination of EEG and fMRI results. The difficult theoretical issues raised by the interpretation of activation and deactivation, both frequently seen in response to spikes, are discussed. Finally, the authors give examples of fMRI responses seen with focal spikes and with generalized spike and wave discharges.
Optimum modulation and multicode formats in CDMA systems with multiuser receivers (2002)

We study the problem of maximizing the total system throughput under a bit error rate constraint for all users in the uplink of a single-cell synchronous CDMA system. Users realize variable bit rates by using a combination of multicode transmission and adaptive QAM modulation. We assume random signature sequences for all users, and perform an asymptotic analysis. We parametrize each user's resource allocation scheme by two parameters, viz., the number of signatures the user transmits with and the number of signal points in the user's QAM constellation, and optimize the total throughput over this parameter space. We examine four different settings: single-user matched filter (SUMF) and minimum-mean-square error (MMSE) receiver at the base station, with and without maximum power constraints. For a single user system, we describe the jointly optimum number of multicodes and constellation sizes for these four different system models. When multiple users are present, we show that the total throughput is maximized when only one user transmits: with no maximum power constraints this user can be chosen arbitrarily, otherwise it should be the one with the largest SNR. This solution, although optimal in the sense of maximizing the total throughput, is unfair to all but one user: thus, we examine a scheduling mechanism that assigns equal time frames to all users, thus yielding maximum fairness, and discuss the resulting total throughput loss.