gebhart/patrepeval huggingface dataset:
Glucocorticoid receptor concentrations and terminal transferase activity as indicators of prognosis in acute non-lymphocytic leukaemia LAMBERT SKOOG, BO NORDENSKJ?LD, ?KE OST, B?RJE ANDERSSON, ROBERT HAST, NICOLOUS GIANNOULIS, SOLVEIG HUMLA, TORSTEN H?GERSTR?M, PETER REIZENSTEIN (2016)

Activity ofterminal deoxynucleotidyl transferase (TdT), adenosine deaminase, and5'nucleotidase andthecellular concentration ofglucocorticoid (dexamethasone) receptor were determined in25patients withacutenon-lymphocytic leukaemia. Allpatients were treated according toa common protocol. Increased activity ofTdT(> 01unit/,ug DNA) was foundin11patients. Thisgroup ofpatients was showntohavehigherremission andsurvival rates (p= 006)comparedwithpatients withlowactivity of TdT.The glucocorticoid receptorconcentration ofthe leukaemic blastcells rangedfrom0to0-94fmol/4g DNA. Thirteenpatients had blastcells witha glucocorticoid receptorconcentration over 0-22fmol/4Lg DNA. These patientshad significantly increasedremissionand survival rates(p=0 006)comparedwiththosewitha low receptorconcentration. Thisfinding cannotbeexplained by a difference insensitivity to glucocorticoids since thesewere not usedas therapeutic agents.Adenosine deaminaseand 5'nucleotidase activities bothvaried within two ordersofmagnitude. No correlation couldbe foundbetweenactivities ofthese enzymes andremission or survival rate. Theseresults showthatmeasurementsofTdT activity and theglucocorticoid receptor concentration yield valuable prognostic information inacutenon-lymphocytic leukaemia.
Prodrug Activation Gated by a Molecular “OR” Logic Trigger (2005)

Molecules that define logic: A molecular “OR” logic gate trigger has been demonstrated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z500842_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Crystalline Si Solar Cells: Applying the Experience from Microelectronics to Improve Efficiency and Reduce Cost (2009)

The PV industry is expected to reduce its manufacturing costs well below 1 Euro/Wattpeak. Major technological changes lie ahead of us for manufacturing wafers, solar cells and modules if this cost target is to be met. The situation will require the same attention as the disruptive introduction of Cu, low-k and high-k materials in the IC industry over the last 2 decades. In order to focus R&amp;D efforts amongst the plentitude of options, and to speed up the learning curve, the PV industry (equipment vendors, material suppliers and PV manufacturers) may benefit from collaborative efforts guided by an ITRS-like roadmap. In this paper we present the IMEC roadmap. The target is to reduce drastically the amount of pure Si needed per Wp, by combining efficiencies beyond 20 % with aggressive reductions in wafer thicknesses. In parallel the manufacturing cost has to be reduced by substituting expensive materials and shortening the manufacturing cycle from quartz sand to module.
Soliton interaction in the presence of a weak nonsoliton component (1994)

We study both experimentally and theoretically soliton interaction in the presence of a weak nonsoliton component and show that the existence of a frequency-shifted cw wave results in a temporal shift of the soliton.
A Mutual Information Measure of Phase-Amplitude Coupling using High Dimensional Sparse Models (2022)

Cross frequency coupling (CFC) between electrophysiological signals in the brain has been observed and it's abnormalities have been observed in conditions such as Parkinson's disease and epilepsy. More recently, CFC has been observed in stomach-brain electrophysiologic studies and thus becomes an enticing possible target for diseases involving aberrations of the gut-brain axis. However, current methods of detecting coupling do not attempt to capture the underlying statistical relationships that give rise to this coupling. In this paper, we demonstrate a new method of calculating phase amplitude coupling by estimating the mutual information between phase and amplitude, using a flexible parametric modeling approach. Specifically, we develop an exponential generalized linear model (GLM) to model amplitude given phase, using a high dimensional basis of von-Mises function regressors and l<sub>1</sub> regularized model selection. Using synthetically generated gut-brain coupled signals, we demonstrate that our method outperforms the existing gold-standard methods for detectable low-levels of phase amplitude coupling through receiver operating characteristic (ROC) curve analysis.
Do HIV-Positive Women with Prior Hysterectomies Require Pap Testing? (2012)

Immunocompetent women who have undergone hysterectomies for benign disease can forgo further Pap testing. Whether this practice can be extended to women with human immunodeficiency virus (HIV) infection was investigated among women with prior hysterectomies enrolled in the Women's Interagency HIV Study and followed for a …
A collection of edge-based elements (1992)

Edge-based elements have proved useful in solving electromagnetic problems since they are nondivergent. Previous authors have presented several two and three dimensional elements. Herein, we present four types of elements which are suitable for modeling several types of three dimensional geometries. Distorted brick and triangular prism elements are given in cartesian coordinates as well as the specialized cylindrical shell and pie-shaped prism elements which are suitable for problems best described in polar cylindrical coordinates.
Biofeedback control of horseback riding simulator (2003)

We have developed a horseback-riding simulator according to horseback riding therapy as an empirical therapy for both physical and mental disease. The effect of increasing muscle strength has been proved by clinical experiment. However, the quantitative exercise can't be realized because the exercise effect is different as everyday condition of everyone's body and individual active muscle is different. In this paper, a portable electromyometer is applied to construct the biofeedback control system. A control strategy that is to adjust the movement mode of the simulator for obtaining certain exercise intension online is proposed. The results of experiments are shown.
Multiple Interleukin-1 Activities in Luteal Phase Human Plasma (1985)

Correlation of IL-1 levels in the human circulation with various physiological and pathological conditions has been hampered by substances in whole plasma or serum which interfere with the in vitro lymphocyte activation assay. Chromatography over G-50 separates most of the interfering factors from IL-1 activity found in the 4-15 kD molecular weight range. Using this method, IL-1 activity was found consistently in plasma from women in the lutcal phase of their menstrual cycle (1) This investigation provides further evidence that the activity is attributable to IL-1 by demonstrating that whole plasma injected into rats reduced their plasma iron levels and that plasma fractions which activated thymocytcs also caused fever when injected into mice
American Society for Enhanced Recovery and Perioperative Quality Initiative Joint Consensus Statement on Nutrition Screening and Therapy Within a Surgical Enhanced Recovery Pathway (2018)

Perioperative malnutrition has proven to be challenging to define, diagnose, and treat. Despite these challenges, it is well known that suboptimal nutritional status is a strong independent predictor of poor postoperative outcomes. Although perioperative caregivers consistently express recognition of the importance of nutrition screening and optimization in the perioperative period, implementation of evidence-based perioperative nutrition guidelines and pathways in the United States has been quite limited and needs to be addressed in surgery-focused recommendations. The second Perioperative Quality Initiative brought together a group of international experts with the objective of providing consensus recommendations on this important topic with the goal of (1) developing guidelines for screening of nutritional status to identify patients at risk for adverse outcomes due to malnutrition; (2) address optimal methods of providing nutritional support and optimizing nutrition status preoperatively; and (3) identifying when and how to optimize nutrition delivery in the postoperative period. Discussion led to strong recommendations for implementation of routine preoperative nutrition screening to identify patients in need of preoperative nutrition optimization. Postoperatively, nutrition delivery should be restarted immediately after surgery. The key role of oral nutrition supplements, enteral nutrition, and parenteral nutrition (implemented in that order) in most perioperative patients was advocated for with protein delivery being more important than total calorie delivery. Finally, the role of often-inadequate nutrition intake in the posthospital setting was discussed, and the role of postdischarge oral nutrition supplements was emphasized.
Effectiveness of catalytic converters on diesel engines used in underground mining. Information Circular/1988 (1988)

The objectives of the report are to quantitatively assess the effects of catalytic converters on diesel-exhaust emissions and to make recommendations for their use. Information in the report is from a literature survey and contact research supported by the Bureau of Mines. Catalytic converters are effective in reducing CO, HC, and odors when the exhaust temperature is high enough so that the converter remains about 250/sup 0/C. Converter temperature is dependent upon engine duty cycle. Catalytic converters increase sulfate emissions and slightly increase oxides of nitrogen (NO) emissions. In addition, in vitro bioassays have shown that catalytic converters produce soluble organic compounds, which have increased mutagenic activity with respect to untreated exhaust.
Diet-Induced Adipose Tissue Inflammation and Liver Steatosis Are Prevented by DPP-4 Inhibition in Diabetic Mice (2011)

Our findings indicated that DPP-4 inhibition has extrapancreatic protective effects against diet-induced adipose tissue inflammation and hepatic steatosis.
Expression of secreted osteoclastogenic factor of activated T cells (SOFAT) by T- and B-lineage cells may contribute significantly to bone loss in periodontitis. (CCR3P.221) (2014)

Abstract A novel T cell-secreted cytokine, termed secreted osteoclastogenic factor of activated T cells (SOFAT), that induces osteoclastic bone resorption in a RANKL-independent manner, has recently been described. We have previously reported that SOFAT is highly expressed in gingival tissues of patients with chronic periodontitis (CP) suggesting a putative role in the bone loss associated with CP. Here we characterized the cell types producing SOFAT in CP. Gingival tissues were biopsied from subjects without periodontal disease (n=5) and patients with CP (n=5) and SOFAT quantified by immunohistochemistry and immunofluorescence staining. Our data reveal marked SOFAT staining in CP that was predominantly associated with the lymphocytic infiltration of gingival tissues. Interestingly, besides CD3+ T cells, B-lineage cells including plasma cells also exhibited strong staining for SOFAT. Because SOFAT has not previously been reported in B-linage cells, we further purified splenic T cells and B cells from Balb/c mice and activated them using LPS or CD3/CD28 antibodies respectively. SOFAT was quantified by RT-qPCR and revealed significant induction of SOFAT expression in both activated T cells and B cells in comparison to unstimulated cells. Our data support a putative role of SOFAT in the bone loss associated with chronic periodontitis and further demonstrates for the first time that in addition to T cells, B-linage cells may also be a significant source of SOFAT in inflammatory states.
Water-soluble, organic fluorophores with powerful electrochemical and photophysical properties (2020)

Welcome to my presentation: "Water-Soluble, Organic Fluorophores with Powerful Electrochemical and Photophysical Properties", which is part of the virtual ACS Spring Meeting 2020.In the next couple of minutes, I will share with you the key results obtained during my PhD studies in the group of Prof. Christof Sparr at the University of Basel. Slide 2 (full-screen image):Small-molecule organic fluorophores are extremely fascinating and simply beautiful to look at. Slide 3 (full-screen image):Additionally, they are also very helpful in visualizing and supporting our understanding of the complex interplay of biomolecules.This is a fluorescence microscopy image with three distinct fluorophores: Fluorescein, rhodamine and DAPI. Slide 4:Century-long development led from these simple fluoresceins and rhodamines, quite complexly substituted organic fluorophores with distinct dye properties and diverse colors.This includes unsymmetrically substituted fluorophores such as ATTO 647 which is present as a racemate due to atropisomerism that occurs from the restricted rotation about the single bond.Interestingly, the distinct interactions of the two enantiomers in a biological environment are still unexplored today. Slide 5:Also current dye syntheses still rely on archetypical Baeyer condensation and Bernthsen-type reactions.These often require high reaction temperatures, an additional oxidation step or highly reactive reagents that limit the desired dye diversity.Also, the more modern heteroanthrone addition of organometallic reagents would require multiple steps to readjust and change the substitution pattern on the heterocyclic moiety.Therefore, a transformation of ACS Spring Meeting 2020
Microstructure, local electronic structure and optical behaviour of zinc ferrite thin films on glass substrate (2018)

Zinc ferrite thin films were deposited using a radio-frequency-sputtering method on glass substrates. As-deposited films were annealed at 200°C for 1, 3 and 5 h, respectively. X-ray diffraction studies revealed the amorphous nature of as-grown and annealed films. Thickness of as-deposited film is 96 nm as determined from Rutherford backscattering spectroscopy which remains almost invariant with annealing. Transmission electron microscopic investigations envisaged a low degree of crystalline order in as-deposited and annealed films. Thicknesses estimated from these measurements were almost 62 nm. Roughness values of these films were almost 1-2 nm as determined from atomic force microscopy. X-ray reflectivity measurements further support the results obtained from TEM and AFM. Near-edge X-ray absorption fine structure measurements envisaged 3+ and 2+ valence states of Fe and Zn ions in these films. UV-Vis spectra of these films were characterized by a sharp absorption in the UV region. All films exhibited almost the same value of optical band gap within experimental error, which is close to 2.86 eV.
Product Complexity and Mode Choice in Global Product Development (2009)

20th Annual Conference of the Production and Operations Management Society (POMS 2009) presentation
Carboxymethylation of dextran in aqueous alcohol as the first step of the preparation of derivatized dextrans (1998)

Carboxymethyldextrans (CMD) with a degree of substitution of carboxymethyl groups DS > 0.9 are precursors for the synthesis of derivatized dextrans termed CMDBS, which present heparin-like biological properties. Syntheses of CMD in water/organic solvent mixtures using monochloroacetic acid (MCA) and strong alkaline conditions allowed to obtain highly substituted CMD with good reproducibility and high yields. The influences of, respectively, individual concentrations of reactants, composition and temperature of reaction medium, and allowed reaction time have been examined. The most favorable conditions for dextran carboxymethylation were obtained with 3.8 M NaOH and a [MCA]/[dextran] ratio of 2.5, allowed to react at 60°C for 90 min, in a reaction medium consisting of a tert-butanol/water (alternatively isopropanol/water) 85 : 15 (v/v) mixture. A DS of about 1.0 was obtained in one step, as compared to a DS less than 0.6 when using aqueous conditions. Improvements on overall CMD substitution levels (up to DS of 1.47) were achieved by merely repeating the reaction i. e. using the CMD products of the first reaction as substrate in the second. Carboxymethyldextrane (CMD) mit einem Substitutionsgrad der Carboxymethylgruppen DS > 0.9 sind Vorstufen für die Synthese von derivatisierten Dextranen (CMDBS) mit heparinähnlichen biologischen Eigenschaften. Die Herstellung von CMD in wäßrigen organischen Lösungsmitteln und in Gegenwart von Monochloressigsäure (MCA) unter stark alkalischen Bedingungen führt mit guter Reproduzierbarkeit und hohen Ausbeuten zu hochsubstituierten CMD. Der Einfluß der Konzentration der Reaktanden, der Zusammensetzung und Temperatur des Reaktionsmediums sowie der Reaktionszeit wurden untersucht. Die günstigsten Bedingungen für die Carboxymethylierung von Dextran zeigten sich mit 3.8 M NaOH, einem [MCA]/[Dextran]-Verhältnis von 2.5, einer Reaktionstemperatur von 60°C und einer Reaktionsdauer von 90 min in einer 85 : 15 (v/v) tert-Butanol/Wasser (alternativ Isopropanol/Wasser)-Mischung als Reaktionsmedium. Ein Substitutionsgrad von etwa 1.0 wurde mit einem Reaktionsschritt erhalten, während unter wäßrigen Bedingungen ein DS von weniger als 0.6 resultierte. Verbesserungen des CMD-Substitutionsgrades (bis zu DS 1.47) wurden durch wiederholte Reaktion erzielt.
Cross-dehydrogenative coupling of ethers and amides with tautomerizable quinazolinones and mechanistic studies (2022)

Cross-dehydrogenative coupling reactions have been utilized to alkylate 4(3<i>H</i>)-quinazolinones with ethers and amides, using catalytic <i>n</i>-Bu<sub>4</sub>NI and <i>t</i>-BuOOH as oxidants. The reactions with amides represent the first examples under such conditions. Studies <i>via</i> inter- and intramolecular competitive experiments with protio and deuterio reactants, as well as radical inhibition experiments, provided mechanistic insight. Also, an understanding of the relative reactivities of ethers was obtained by pairwise competitions with 4(3<i>H</i>)-quinazolinone.
Deposition Methods for the Integration of Molecularly Imprinted Polymers (MIPs) in Sensor Applications (2023)

Abstract Offering high specificity and selectivity, molecularly imprinted polymers (MIPs) are synthetic polymeric affinity reagents that have become increasingly popular over the last couple of decades. Due to their long‐term chemical and physical stability and low production cost, they have become an increasingly popular choice of receptor in the realm of sense. MIPs have therefore been associated with the detection of small molecules, proteins, cells, and pathogens, proving a highly robust and useful tool in the production of next‐gen sensing platforms. This said, the development of these sensors pivots on one simple fact; these receptors have to be deposited onto a substrate for their desired application. The deposition of MIPs during sensor fabrication is therefore of great importance, with the field utilizing an array of mechanical and chemical deposition methods to achieve this. To this end, this review, therefore, sets aim at coalescing these different deposition approaches, classifying them, and outlining their utility when it comes to receptor design and integration. Thus, offering a knowledge base on current deposition methods, potential future approaches and analyzing where the MIP deposition field is tending toward.
Using Image Fairness Representations in Diversity-Based Re-ranking for Recommendations (2018)

The trade-off between relevance and fairness in personalized recommendations has been explored in recent works, with the goal of minimizing learned discrimination towards certain demographics while still producing relevant results. We present a fairness-aware variation of the Maximal Marginal Relevance (MMR) re-ranking method which uses representations of demographic groups computed using a labeled dataset. This method is intended to incorporate fairness with respect to these demographic groups. We perform an experiment on a stock photo dataset and examine the trade-off between relevance and fairness against a well known baseline, MMR, by using human judgment to examine the results of the re-ranking when using different fractions of a labeled dataset, and by performing a quantitative analysis on the ranked results of a set of query images. We show that our proposed method can incorporate fairness in the ranked results while obtaining higher precision than the baseline, while our case study shows that even a limited amount of labeled data can be used to compute the representations to obtain fairness. This method can be used as a post-processing step for recommender systems and search.
Synthetic Complementary Peptides Inhibit a Neutrophil Chemoattractant Found in the Alkali-injured Cornea (2000)

Purpose. We have previously presented evidence that the neutrophil chemoattractant, N-acetyl-proline-glycine-proline (N-acetyl-PGP), triggers the initial polymorphonuclear leukocyte (PMN) invasion into the alkali-injured eye. In this study, sense–antisense methodology was used to develop novel complementary peptides to be potential inhibitors of N-acetyl-PGP. Methods. The polarization assay was used to measure the potential chemotactic response of PMNs to synthetic N-acetyl-PGP, the ultrafiltered tripeptide chemoattractants obtained from alkali-degraded rabbit corneas, or leukotriene B4 (LTB4). Inhibition was expressed as the peptide concentration producing 50% inhibition (ID50) of polarization. Five complementary peptides were tested as potential inhibitors of N-acetyl-PGP: arginine-threonine-arginine (RTR), RTR-glycine-glycine (RTRGG), RTR dimer, RTR tetramer, and alanine-serine-alanine (ASA) tetramer. In addition, the RTR tetramer and both monomeric peptides (RTR and RTRGG) were separately tested for inhibition of the ultrafiltered tripeptide chemoattractants or LTB4. Results. The complementary RTR tetrameric peptide was a powerful antagonist of N-acetyl-PGP-induced PMN polarization (ID50 of 200 nM). The RTR dimer was much less potent (ID50 of 105 μM). Both monomeric peptides, RTR and RTRGG, were only antagonistic at millimolar concentrations. The ASA tetramer showed no capacity to inhibit N-acetyl-PGP. The RTR tetramer also inhibited PMN activation by the ultrafiltered tripeptide chemoattractants (ID50 of 30 μM) but had no effect on LTB4. Conclusions. A complementary peptide (RTR) was designed which is an effective inhibitor of the neutrophil chemoattractant, N-acetyl-PGP. The potency of the RTR complementary peptide is dramatically enhanced by tetramerization. Inhibition of N-acetyl-PGP by complementary peptides offers great promise for control of the inflammatory response in the alkali-injured eye.