gebhart/patrepeval huggingface dataset:
Holographic Scanners For Machine Vision, Printing, And Bar Code Applications. (1987)

Holographic scanners/deflectors have been used to replace common mirrors with very limited success. When an application requires more than a simple polygon or when two or three functions can be performed by a single holographic element then the holographic approach appears more attractive and historically has been more successful. This paper reveiws 3 special purpose device designs with emphasis on the hologram design considerations, fabrication details and performance.
Nematicon-driven injection of amplified spontaneous emission into an optical fiber (2016)

We investigate experimentally the interaction between amplified spontaneous emission (ASE) and a soliton, which are both generated in a dye-doped nematic liquid crystal (LC) cell. A light beam is injected through an optical fiber slid into the cell to form a soliton beam. ASE is then automatically collected by this self-induced waveguide and efficiently coupled into the same optical fiber, in the backward direction. We demonstrate that the presence of the soliton improves the ASE collection by one order of magnitude. We also show that the ASE is highly polarized in the plane of the LC cell and that the ASE spectrum depends on the pump stripe orientation with respect to the LC director. The origin of the spectral anisotropy of the gain curves is determined with the help of femtosecond pump-probe spectroscopy.
SNP–SNP Interactions of Surfactant Protein Genes in Persistent Respiratory Morbidity Susceptibility in Previously Healthy Children (2022)

We studied associations of persistent respiratory morbidity (PRM) at 6 and 12 months after acute respiratory failure (ARF) in previously healthy children with single-nucleotide polymorphisms (SNPs) of surfactant protein (SP) genes. Of the 250 enrolled subjects, 155 and 127 were followed at 6 and 12 months after an ARF episode, respectively. Logistic regression analysis and SNP-SNP interaction models were used. We found that 1) in the multivariate analysis, an increased risk at 6 and 12 months was associated with rs1124_A and rs4715_A of <i>SFTPC</i>, respectively; 2) in a single SNP model, increased and decreased risks of PRM at both timepoints were associated with rs1124 of <i>SFTPC</i> and rs721917 of <i>SFTPD</i>, respectively; an increased risk at 6 months was associated with rs1130866 of <i>SFTPB</i> and rs4715 of <i>SFTPC</i>, and increased and decreased risks at 12 months were associated with rs17886395 of <i>SFTPA2</i> and rs2243639 of <i>SFTPD</i>, respectively; 3) in a two-SNP model, PRM susceptibility at both timepoints was associated with a number of intergenic interactions between SNPs of the studied SP genes. An increased risk at 12 months was associated with one intragenic (rs1965708 and rs113645 of <i>SFTPA2</i>) interaction; 4) in a three-SNP model, decreased and increased risks at 6 and 12 months, respectively, were associated with an interaction among rs1130866 of <i>SFTPB</i>, rs721917 of <i>SFTPD</i>, and rs1059046 of <i>SFTPA2</i>. A decreased risk at 6 months was associated with an interaction among the same SNPs of <i>SFTPB</i> and <i>SFTPD</i> and the rs1136450 of <i>SFTPA1</i>. The findings revealed that SNPs of all <i>SFTP</i>s appear to play a role in long-term outcomes of ARF survivors and may serve as markers for disease susceptibility.
Abiraterone induces SLCO1B3 expression in prostate cancer via microRNA-579-3p (2021)

Understanding mechanisms of resistance to abiraterone, one of the primary drugs approved for the treatment of castration resistant prostate cancer, remains a priority. The organic anion polypeptide 1B3 (OATP1B3, encoded by SLCO1B3) transporter has been shown to transport androgens into prostate cancer cells. In this study we observed and investigated the mechanism of induction of SLCO1B3 by abiraterone. Prostate cancer cells (22Rv1, LNCaP, and VCAP) were treated with anti-androgens and assessed for SLCO1B3 expression by qPCR analysis. Abiraterone treatment increased SLCO1B3 expression in 22Rv1 cells in vitro and in the 22Rv1 xenograft model in vivo. MicroRNA profiling of abiraterone-treated 22Rv1 cells was performed using a NanoString nCounter miRNA panel followed by miRNA target prediction. TargetScan and miRanda prediction tools identified hsa-miR-579-3p as binding to the 3'-untranslated region (3'UTR) of the SLCO1B3. Using dual luciferase reporter assays, we verified that hsa-miR-579-3p indeed binds to the SLCO1B3 3'UTR and significantly inhibited SLCO1B3 reporter activity. Treatment with abiraterone significantly downregulated hsa-miR-579-3p, indicating its potential role in upregulating SLCO1B3 expression. In this study, we demonstrated a novel miRNA-mediated mechanism of abiraterone-induced SLCO1B3 expression, a transporter that is also responsible for driving androgen deprivation therapy resistance. Understanding mechanisms of abiraterone resistance mediated via differential miRNA expression will assist in the identification of potential miRNA biomarkers of treatment resistance and the development of future therapeutics.
Foods at Subzero Temperatures (2004)

Food freezing has become awell-established food preservation technique. It is quite a new process, in contrast to the traditional presentation techniques, that owes its beginnings to the development of mechanical refrigeration and has really only been developed over the last half-century [1]. That it has gained such widespread importance is due to the fact that it delivers to the consumer many desirable attributes: high-quality products, diversity in meal preparation, and convenience. This latter attribute received a tremendous boost in importance with the development and widespread use of home microwave ovens, which are now seen to be an integral part of the development and home utilization of frozen foods [1].
Role of Hepatocyte Growth Factor in Endothelial-Dependent Hematopoietic Stem Cell Regeneration (2014)

Abstract Hematopoiesis is tightly regulated by the niche and highly sensitive to a variety of genotoxic stressors. The mechanisms responsible for the repair and regeneration of hematopoietic stem cells (HSCs) are poorly understood. Endothelial cells (ECs) are an essential component of the bone marrow microenvironment that provide regenerative signals for HSCs after injury; however, the identity of these signals remain largely unknown. We utilized RNA sequencing and a bioinformatics approach to identify hepatocyte growth factor (HGF) as an endothelial-derived mediator of HSC regeneration. HGF gene expression was 7.6-fold higher in arterial-derived ECs (HAEC) that regenerate functional long-term HSCs (CD150+LineageloSca1+Kit+ cells; CD150+LSK cells) compared to venous ECs (HUVEC) that support only hematopoietic progenitors. Furthermore, the HSC-supportive HAECs secreted up to 25 pg/mL HGF into conditioned media, whereas HGF was undetectable in media conditioned by HUVEC. To directly test the role of HGF in HSC regeneration, we supplemented co-cultures of irradiated bone marrow cells and primary ECs with recombinant HGF. Addition of HGF was sufficient to augment CD150+LSK cell regeneration up to 20-fold by HUVEC. This effect was abolished by treatment with the Met-specific small molecular inhibitor, PF04217903. Importantly, neither the addition of HGF alone to irradiated hematopoietic cells nor spiking HUVEC-conditioned media with HGF improved HSC regeneration in the absence of an EC monolayer. Together, these results indicate that HGF activates a signaling loop in ECs that supports HSC regeneration. Disclosures No relevant conflicts of interest to declare.
Passive reconstruction of non-target-specific discrete-time LTI systems (2016)

Much of the existing literature on the reconstruction of a system's dynamical structure functions has focused on learning the structure of a system using experiments in which each measured state must be perturbed independently. This work develops a reconstruction procedure that does not require multiple targeted experiments, instead determining the structure of the network when inputs are drawn from a Gaussian distribution and are active simultaneously. Although similar reconstruction procedures exist in the literature, this algorithm removes the restriction of target specificity, which states that each input must independently affect a measured state in the system. This allows for the reconstruction procedure to be applied to a larger number of networks that were previously not reconstructible because of their inherent structure. Furthermore, this is the first reconstruction procedure on the dynamical structure function to operate in the time-domain, rather than the frequency domain, in order to avoid the overhead and inaccuracies that could be introduced through transformations.
The Great Lakes-St. Lawrence River Basin from an IJC Perspective (1992)

There are, of course, many ways to look at the Great Lakes-St.Law- rence Basin.The focus can be on geography, water quality, socio-economic considerations or legal and regulatory regimes, to name just a few.In fact, the International Joint Commission ("IJC") now tries to incorporate all relevant considerations in its work through what is termed an "ecosystem approach".However, in the last analysis, the IJC's perspective is the perspective of its mandate, which is set out in the Boundary Waters Treaty of 1909.The Boundary Waters Treaty was concluded between the United States and the United Kingdom at a time when the U.K. had responsibility for Canada's international relations.As Canada gained the attributes of nationhood in the 1920s, it succeeded to Britain's rights and duties under the Boundary Waters Treaty.The immediate effect of the Treaty was to resolve two specific issues: the apportionment of the St. Mary and Milk Rivers in the West and the diversion of water for power generation at Niagara Falls.In addition, it provided a mechanism for resolving difficulties between the two countries concerning the use of waters flowing along or across the boundary.It also went somewhat further and, in the preamble, stated that both Parties, who are today the Governments of Canada and the United States, were equally desirous:... to prevent disputes regarding the use of boundary waters and to settle all questions which are now pending between the United States and the Dominion of Canada involving the rights, obligations, or interests of either in relation to the other or to the inhabitants of the other, along their common frontier, and to make provision for the adjustment and settlement of all such questions as may hereinafter arise .... To achieve this goal, the Treaty set out a number of principles and established the IJC to play a key role in the resolution and avoidance of disputes.Since that time, the IJC has become one of several mechanisms available to assist the two Governments in resolving issues along the border.
Comparative Pharmacokinetic Analysis of Community Use Naloxone formulations for Acute Treatment of Opioid Overdose (2019)

Recent increases in mortality from overdoses in the US have been primarily driven by deaths due to the more potent synthetic opioids. Naloxone is an effective countermeasure to treat opioid overdose. We compared the pharmacokinetics of the three available doses of naloxone used to treat prehospital opioid overdoses. Overall, the systemic exposures of 2 mg intramuscular and 4 mg intranasal of naloxone appear to be similar. By comparison, the exposure levels of the 5 mg dose intramuscular naloxone (ZIMHI) appears to be greater and more rapid. These results support the notion that higher doses of naloxone result in greater bioavailability which may be required for reversal due to the more potent synthetic opioids, such as fentanyl.
Vote-taking for EUV lithography: a radical approach to mitigate mask defects (2017)

Vote-taking lithography sums up N mask images, each at 1/N dose, to mitigate the mask defects on each individual mask. The fundamental assumption is that the mask defects do not correlate in position from mask to mask, and so each individual defect will be blended with good images from the other N-1 masks. This paper will explore vote-taking for EUV lithography with both simulation and experimental results. PROLITH simulations will show the size of defects that can be healed for different N, the number of masks. SEM images of NXE 3300 exposures will be shown that are similar to those predicted from simulation. The implementation of vote-taking lithography for High Volume Manufacturing has huge practical and economic barriers. Some expose tool capabilities that could enable vote-taking lithography will be discussed. Besides defect mitigation, we briefly speculate on other possible imaging benefits opened up by voting with several exposure passes.
Geospatial Distribution and Accessibility of Primary and Secondary Schools: A case of Abbottabad City, Pakistan (2019)

Abstract. Quality education in isolated areas is a major issue in developing countries like Pakistan, as access to formal education is linked to improved life prospects for rural students. Among the factors for education, accessibility is school availability within a minimum spatial distance. The spatial distribution of schools is generally uneven in most of the cities of Northern Pakistan, thus limiting access to formal education at the primary and secondary level. This paper analyzes the spatial distribution of the primary and secondary schools found in the hilly terrain of Abbottabad city. Results show an uneven scattered pattern of schools and decreasing accessibility with longer travel times, at higher costs. Cost-weighted distance showed that this spatial distribution extends the travel distance by more than 5km for secondary school students living in the city. However, spatial restructuring and reorganization of schools in the study area would enhance student access to school facilities.
Semiconductor surface diffusion: Nonthermal effects of photon illumination (2000)

Nonthermal influences of photon illumination on surface diffusion at high temperatures have been measured experimentally. Activation energies and pre-exponential factors for diffusion of germanium, indium, and antimony on silicon change by up to 0.3 eV and two orders of magnitude, respectively, in response to illumination by photons having energies greater than the substrate band gap. The parameters decrease for n-type material and increase for p-type material. Aided by results from photoreflectance spectroscopy, we suggest that motion of the surface quasi-Fermi-level for minority carriers accounts for much of the effect by changing the charge states of surface vacancies. An additional adatom-vacancy complexation mechanism appears to operate on p-type substrates. The results have significant implications for aspects of microelectronics fabrication by rapid thermal processing that are governed by surface mobility.
Participación de la comunidad de Huanchaquito bajo en la gestión del patrimonio arqueológico de Gramalote como alternativa de promoción turística (2017)

ABSTRACT
COMMUNITY INVOLVEMENT HUANCHAQUITO LOW IN ASSET MANAGEMENT AS AN ALTERNATIVE
GRAMALOTE ARCHAEOLOGICAL TOURISM PROMOTION
This research addressed the theme: Participation of the Community of Huanchaquito Under the
Archaeological Heritage Management Gramalote alternative tourism They tried to show, in the
desire to involve the community, the management mechanisms archaeological heritage in the Site Gramalote,
the same that is located in Sector Huanchaquito Low, District of Huanchaco, Trujillo Province. This heritage is
very close to the community of the same name, also located adjacent to the local commune of the sector is
therefore intended that involve, in order to participate actively in the tourist promotion of this heritage.
The objectives was to establish alternatives to promote participation of the Community of Huanchaquito Under
the Archaeological Heritage Management Gramalote alternative tourism promotion, in order to contribute to the
identity and the cultural development of the community.
With respect to the research methodology used, the ethnographic method that served to know the cultural
characteristics of the community Huanchaquito Low, that is able to verify in situ the reality under study related
to the independent variable of community identity was applied so as the deductive method - inductive that
identified not only the theoretical indicators of the archaeological heritage of Gramalote stuff research.
techniques were used as surveys and interviews, both residents of the community and their local authorities,
the same that permit to demonstrate the validity of our hypothesis as the results obtained so far have indicated
that the community Huanchaquito Low and managers of the commune have an idea of what is heritage and
tourism, but in reality is not translated in their attitudes, so your regular lack of interest is translated in the low
active participation for the proper functioning of tourism promotion of their cultural heritage.
RC-101, a Retrocyclin-1 Analogue with Enhanced Activity against Primary HIV Type 1 Isolates (2004)

Rhesus macaques express three θ-defensins (RTDs 1–3), cyclic octadecapeptides with antiviral and lectin-like properties. Corresponding θ-defensin genes exist and are expressed in humans, but a signal sequence mutation prevents the formation of mature θ-defensin peptides. Retrocyclin-1 is a θ-defensin peptide whose precursor is encoded by human θ-defensin pseudogenes. It can protect human peripheral blood lymphocytes from infection by R5 and X4 strains of HIV-1, and provides a molecular template for designing novel antiviral agents. In this study, we used JC53-BL reporter cells to assess the activity of retrocyclin-1 (RC-100) and several analogues against primary HIV-1 isolates, including R5 and R5X4 strains of subtypes A–D, CRF-01_AE, and recombinants. Each analogue differed from retrocyclin-1 by a single amino acid substitution: Gly ↠ Tyr in RC-106, RC-115, and RC-116, and Arg ↠ Lys in RC-101. Although the modification in RC-101 was chemically conservative, this peptide was significantly more potent than retrocyclin-1 across the panel of primary isolates. We performed surface plasmon resonance binding studies, using recombinant gp120 and CD4 produced in insect cells. Although RC-100 and RC-101 bound gp120 LAV/IIIB with a Kd of 30–35 nM, they bound gp120 from CRF-01_AE strains (CM 235 and 93TH975.15) with Kd values of 200–750 nM. Overall, our findings suggest that clade-related differences in gp120 glycosylation impact the ability of retrocyclin-1 to bind this viral glycoprotein, and modulate the peptides' ability to prevent HIV-1 infection. The performance of RC-101 suggests that additional "engineering" could further enhance the antiviral properties of θ-defensins.
Lipoprotein-associated phospholipase A2 does not predict mortality or new ischaemic events in acute coronary syndrome patients (2007)

ACS patients had higher Lp-PLA(2) levels than healthy controls. Lp-PLA(2) was significantly correlated to lipid levels but only weakly correlated or unrelated to other well-established risk markers in ACS. The risk of future cardiovascular events or mortality was not related to Lp-PLA(2) levels in ACS patients. The biological role of Lp-PLA(2) and its role as a risk marker in ACS patients still remain unclear.
Hybrid Precoding for Mixture Use of Phase Shifters and Switches in mmWave Massive MIMO (2022)

A variable-phase-shifter (VPS) architecture with hybrid precoding for mixture use of phase shifters and switches, is proposed for millimeter wave massive multiple-input multiple-output communications. For the VPS architecture, a hybrid precoding design (HPD) scheme, called VPS-HPD, is proposed to optimize the phases according to the channel state information by alternately optimizing the analog precoder and digital precoder. To reduce the computational complexity of the VPS-HPD scheme, a low-complexity HPD scheme for the VPS architecture (VPS-LC-HPD) including alternating optimization in three stages is then proposed, where each stage has a closed-form solution and can be efficiently implemented. To reduce the hardware complexity introduced by the large number of switches, we consider a group-connected VPS architecture and propose a HPD scheme, where the HPD problem is divided into multiple independent subproblems with each subproblem flexibly solved by the VPS-HPD or VPS-LC-HPD scheme. Simulation results verify the effectiveness of the propose schemes and show that the proposed schemes can achieve satisfactory spectral efficiency performance with reduced computational complexity or hardware complexity.
COMSAT's ATM satellite services (1996)

COMSAT's new ATM satellite service employs advanced satellite interface technology to transport high quality ATM traffic in a bandwidth efficient way. In the life-cycle planning for these interface devices new features may soon be added that will enable processing of switched virtual circuits, extend the data compression feature for input rates up to 8 Mbit/s, add SNMP-based equipment control, and allow optional terrestrial interfaces that can accommodate frame relay traffic. Alpha and beta tests have been completed for the ALA and ALE, with results showing that performance standards are met when ALA/ALE devices are deployed between the ATM switch and the modem. As these ATM-enabling interfaces are deployed commercially, international expansion of ATM networks via satellite will have real potential. (7 pages)
Divergent low-density lipoprotein receptor (LDLR) linked to low VSV G-dependent viral infectivity and unique serum lipid profile in zebra finches (2021)

The low-density lipoprotein receptor (LDLR) is key to cellular cholesterol uptake and is also the main receptor for the vesicular stomatitis virus glycoprotein (VSV G). Here we show that in songbirds LDLR is highly divergent and lacks domains critical for ligand binding and cellular trafficking, inconsistent with universal structure conservation and function across vertebrates. Linked to the LDLR functional domain loss, zebra finches show inefficient infectivity by lentiviruses (LVs) pseudotyped with VSV G, which can be rescued by the expression of human LDLR. Finches also show an atypical plasma lipid distribution that relies largely on high-density lipoprotein (HDL). These findings provide insights into the genetics and evolution of viral infectivity and cholesterol transport mechanisms in vertebrates.
Scientific Writing for Impact Factor Journals (2015)

Lichtfouse E. New York: Nova Science Publishers Inc, 2013. pp 87. $52.00. ISBN: 978-1-62618-943-0

Effective scientific writing is a fundamental skill required for all researchers in order to communicate ideas and knowledge clearly and effectively. Scientific Writing for Impact Factor Journals is an outstanding writing guide for scientific publication. The author, Eric Lichtfouse, is the Chief Editor of the journal Agronomy for Sustainable Development that has been awarded the highest per cent increase in citations in the field of agricultural sciences by the essential science indicators. He is also the Chief Editor and founder of Environmental Chemistry Letters and books in the field. Based on his experience in the field as a chief editor, Lichtfouse has constructed his book offering tips and directions for young researchers and doctoral students on the craft of writing publishable manuscripts and scientific communication. This book is an excellent and practical, step-by-step guide in the field of writing that is supported with examples and great summarising illustrations and tables.

The book is divided into two main sections: General advice and Tips by section. The book ends with appendices that …