gebhart/patrepeval huggingface dataset:
Channel structure and divalent cation regulation of phototransduction (1995)

Abstract The identification of additional subunits of the cGMP-gated cation channel suggests exciting questions about their regulatory roles and about structure/functional relationships. How do the different subunits interact? How is the complex assembled into the plasma membrane? Divalent cations have been implicated in the regulation of adaptation. One often overlooked cation is magnesium. Could this ion play a role in phototransduction?
Calcification of Advanced Atherosclerotic Lesions in the Innominate Arteries of ApoE-Deficient Mice (2005)

Calcification of advanced lesions in chow-fed apolipoprotein E-deficient mice occurs reproducibly in mice between 45 and 75 weeks of age. The deposition of hydroxyapatite is mediated by chondrocytes, which suggests that the mechanism of calcification may in part recapitulate the process of endochondral bone formation.
Impact of Current Management Practices on Early and Late Death in More Than 500 Consecutive Cardiac Transplant Recipients (2000)

Previously identified risk factors did not adversely affect short- or long-term survival of heart transplant recipients in the current era. The steady improvement in survival during this period argues that advances in transplantation have offset the increasing acuity of transplant recipients.
A wearable and mobile intervention delivery system for individuals with panic disorder (2015)

Panic disorder is a serious condition that affects approximately six million adults in the United States per year. Reducing the severity of panic attack symptoms would allow a better quality of life for panic attack sufferers. This paper presents steps towards a mobile and wearable system that aims to help reduce the severity of symptoms experienced by individuals with this condition. The system provides a way to continuously monitor the physiological data of an individual via a wearable device. Users are able to report when panic attacks take place, along with a rating of the severity of symptoms experienced. Reported episodes provide ground truth data to build panic prediction models. The eventual goal of the system is to make predictions about approaching panic attacks and to deliver interventions that help the individual to cope with the approaching episode. We describe a mobile-based intervention that has been developed, which instructs the individual to perform breathing and relaxation exercises. Presently, the system has been utilized in a small pilot study where 10 individuals who suffer from panic disorder reported 29 panic attacks while collecting physiological data, along with the severity of symptoms. We found that out of 15 symptoms the ones with high severity reported were anxiety, worry and shortness of breath. Furthermore, physiological differences were observed between panic and non-panic intervals.
CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention (2020)

The DNA-binding protein CCCTC-binding factor (CTCF) and the cohesin complex function together to shape chromatin architecture in mammalian cells, but the molecular details of this process remain unclear. Here, we demonstrate that a 79-aa region within the CTCF N terminus is essential for cohesin positioning at CTCF binding sites and chromatin loop formation. However, the N terminus of CTCF fused to artificial zinc fingers was not sufficient to redirect cohesin to non-CTCF binding sites, indicating a lack of an autonomously functioning domain in CTCF responsible for cohesin positioning. BORIS (CTCFL), a germline-specific paralog of CTCF, was unable to anchor cohesin to CTCF DNA binding sites. Furthermore, CTCF-BORIS chimeric constructs provided evidence that, besides the N terminus of CTCF, the first two CTCF zinc fingers, and likely the 3D geometry of CTCF-DNA complexes, are also involved in cohesin retention. Based on this knowledge, we were able to convert BORIS into CTCF with respect to cohesin positioning, thus providing additional molecular details of the ability of CTCF to retain cohesin. Taken together, our data provide insight into the process by which DNA-bound CTCF constrains cohesin movement to shape spatiotemporal genome organization.
Analysis and Implementation of Doherty Power Amplifier With Two-Point Envelope Modulation (2012)

In this paper, the effect of the fundamental current provided by a peaking cell consisting of a Doherty amplifier is analyzed using a new closed-current model. The proposed current model can be used as a foundation to accurately explain and optimize previous compensation methods such as uneven, asymmetric, and gate envelope cases. Based on the proposed analysis, and in conjunction with the envelope tracking scheme, two-point envelope modulation simultaneously supplying the carrier and peaking cells is introduced to improve the overall efficiency. For further verification, the Doherty amplifier, targeting a third-generation long-term evolution base station at 2.6 GHz has been fabricated utilizing a commercially available 120-W gallium nitride device, which provides a drain efficiency of 53.1% at an average output power of 45.8 dBm with an 8.5-dB peak-to-average power ratio signal maintaining an adjacent channel leakage power ratio of - 48.6 dBc using digital pre-distortion functionality.
Hydrogen Bonding as a Construction Element for Bidentate Donor Ligands in Homogeneous Catalysis: Regioselective Hydroformylation of Terminal Alkenes. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Supporting 'team science' to achieve ambitious Cancer Moonshot goals. (2016)

Since President Barack Obama laid out a vision for a Cancer Moonshot research initiative during his 2016 State of the Union address, the public and private sectors have moved swiftly to respond with multiple activities aimed at achieving progress against the many diseases we classify under the heading of cancer.
[Viscoelastic properties of normal human synovia and their relation to biomechanics]. (1985)

The viscoelastic parameters of synovial fluid (SF) collected from donors with healthy joints were investigated in a shear rate range between D = 10(-3) to 10(+3) s-1. The rheological parameters obtained from these SF yielded a common Master-curve, which can be accepted as characteristic for healthy human FS: it shows high zero shear viscosity (6-60 Pa X s) and pronounced shear thinning with increasing shear rates. The shear module G, calculated from the first normal stress difference, shows a constant range with values between 1 and 5 Pa. The largest average relaxation times are observed in the range of 2 to 5 s, and they decrease linearly with increasing shear rate to values of 0.01 to 0.05 s. The above viscoelastic properties appear to be necessary for the formation of a fluid film to guarantee optimal joint lubrication and to protect the cartilage from mechanical damage.
Tau pathology propagation in mice models induced by native human Alzheimer PHF. (2019)

DI-fusion, le Dépôt institutionnel numérique de l'ULB, est l'outil de référencementde la production scientifique de l'ULB.L'interface de recherche DI-fusion permet de consulter les publications des chercheurs de l'ULB et les thèses qui y ont été défendues.
Digitoxin induces apoptosis in cancer cells by inhibiting nuclear factor of activated T-cells-driven c-MYC expression (2013)

These results suggest that the carcinotoxic activity of digitoxin includes suppression of NFAT-driven c-MYC expression.
Utilization of macrophages in anticancer therapy: the macrophage network theory. (2004)

Appropriate and rational modulation of innate immunity may enhance the therapeutic efficacy of emerging immune therapies for treating cancer. One of the crucial cells of innate immunity is the macrophage. The purpose of this article was to review those issues that suggest ways of exploiting macrophage local functions in immune therapy, and to discuss the suitability of low molecular-weight lipopolysaccharides as potent modulators of macrophage functions for immune therapy of cancer.
Experimental validation of the numerical model of a commercial mobile phone for specific absorption rate assessment (2014)

International audience
Chemoenzymatic Synthesis of Enantiopure Structured Triacylglycerols (2008)

A highly efficient chemoenzymatic method for the synthesis of enantiopure ABC-type asymmetrically structured triacyl­glycerols has been developed starting from enantiopure (S)-solketal and involving two lipase steps.
Liquid direct reactive interface printing of structural aluminum alloys (2018)

Direct reactive interface printing is a fused filament fabrication method that exploits specially designed alloys with reactive chemistries and, in this example, structurally significant mechanical properties. Spatial control and fully molten filament stability are driven by high surface energy interfaces resulting from high formation enthalpy. In this study, molten Al–Ce-based alloys are deposited directly onto a build surface where they rapidly solidify, retaining an intended shape, and successive layers bond to one another through highly reactive interfaces. Significant free space spanning, greater than 5 cm, is demonstrated. Electron microscopy and nanoindentation are used to examine the metallurgical bond. The use of efficient electromagnetic heating and low-cost feedstock, such as cast performs or wires rather than powders, can lower equipment costs and increase scalability and adaptation.
Joint resource management and action scheduling for carrier-grade NFV (2021)

Software upgrades, reconfiguration, and deployment of new services happen so frequently in the carrier-grade VNF-based networks that operators need automated orchestration and change management systems. The current approaches deal independently with each service and concentrate mainly on resource allocation or optimization of the change execution processes. We propose a new Joint Resource Allocation and Scheduling (JRAS) approach, where the orchestrator manages changes, addressing the diverse requirements and dependencies of all services together. These features result in significant gain achieved by JRAS compared to other approaches, as shown by the performed numerical analysis.
50-ps Passively Mode-Locked Red Praseodymium Laser (2014)

We report on the first SESAM mode-locked visible praseodymium laser. Self-starting continuous-wave mode locking operation with 50-ps pulses and an output power of 16 mW at a wavelength 639.5 nm is achieved.
Genome Sequence of Rhodococcus erythropolis Strain CCM2595, a Phenol Derivative-Degrading Bacterium (2014)

We announce the completion of the genome sequence of a phenol derivative-degrading bacterium, Rhodococcus erythropolis strain CCM2595. This bacterium is interesting in the context of bioremediation for its capability to degrade phenol, catechol, resorcinol, hydroxybenzoate, hydroquinone, p-chlorophenol, p-nitrophenol, pyrimidines, and sterols.
SpyB, a Small Heme-Binding Protein, Affects the Composition of the Cell Wall in Streptococcus pyogenes (2016)

<i>Streptococcus pyogenes</i> (Group A <i>Streptococcus</i> or GAS) is a hemolytic human pathogen associated with a wide variety of infections ranging from minor skin and throat infections to life-threatening invasive diseases. The cell wall of GAS consists of peptidoglycan sacculus decorated with a carbohydrate comprising a polyrhamnose backbone with immunodominant N-acetylglucosamine side-chains. All GAS genomes contain the <i>spyBA</i> operon, which encodes a 35-amino-acid membrane protein SpyB, and a membrane-bound C3-like ADP-ribosyltransferase SpyA. In this study, we addressed the function of SpyB in GAS. Phenotypic analysis of a <i>spyB</i> deletion mutant revealed increased bacterial aggregation, and reduced sensitivity to β-lactams of the cephalosporin class and peptidoglycan hydrolase PlyC. Glycosyl composition analysis of cell wall isolated from the <i>spyB</i> mutant suggested an altered carbohydrate structure compared with the wild-type strain. Furthermore, we found that SpyB associates with heme and protoporphyrin IX. Heme binding induces SpyB dimerization, which involves disulfide bond formation between the subunits. Thus, our data suggest the possibility that SpyB activity is regulated by heme.
Thermal, Chemical, and Biological Processing (1997)

This session focuses on processing steps required to convert the carbohydrates of biomass into fuels and chemicals. For illustrative purposes, Fig. 1 shows a representative block flow diagram for a bioethanol process. (Of course, other approaches may be taken as well.) First, the biomass is pretreated to render it more digestible. Then enzymes are added that hydrolyze cellulose and hemicellulose into sugars. Finally, microorganisms (e.g., yeast) ferment these sugars to ethanol, which is recovered by distillation. The papers in this session describe various aspects of the process shown in Fig. 1, such as new developments in pretreatments, models of the saccharification and fermentation steps, enzyme recovery, combined enzyme/ethanol production, and a process that allows ethanol to be produced from biomass contaminated with radioactivity.
Liquid Crystal Enabled Early Stage Detection of Beta Amyloid Formation on Lipid Monolayers (2015)

Liquid crystals (LCs) can serve as sensitive reporters of interfacial events, and this property has been used for sensing of synthetic or biological toxins. Here it is demonstrated that LCs can distinguish distinct molecular motifs and exhibit a specific response to beta‐sheet structures. That property is used to detect the formation of highly toxic protofibrils involved in neurodegenerative diseases, where it is crucial to develop methods that probe the early‐stage aggregation of amyloidogenic peptides in the vicinity of biological membranes. In the proposed method, the amyloid fibrils formed at the lipid–decorated LC interface can change the orientation of LCs and form elongated and branched structures that are amplified by the mesogenic medium; however, nonamyloidogenic peptides form ellipsoidal domains of tilted LCs. Moreover, a theoretical and computational analysis is used to reveal the underlying structure of the LC, thereby providing a detailed molecular‐level view of the interactions and mechanisms responsible for such motifs. The corresponding signatures can be detected at nanomolar concentrations of peptide by polarized light microscopy and much earlier than the ones that can be identified by fluorescence‐based techniques. As such, it offers the potential for early diagnoses of neurodegenerative diseases and for facile testing of inhibitors of amyloid formation.
An approach to online network monitoring using clustered patterns (2017)

Network traffic monitoring is a core element in network operations and management for various purposes such as anomaly detection, change detection, and fault/failure detection. In this paper, we introduce a new approach to online monitoring using a pattern-based representation of the network traffic. Unlike the past online techniques limited to a single variable to summarize (e.g., sketch), the focus of this study is on capturing the network state from the multivariate attributes under consideration. To this end, we employ clustering with its benefit of the aggregation of multidimensional variables. The clustered result represents the state of the network with regard to the monitored variables, which can also be compared with the previously observed patterns visually and quantitatively. We demonstrate the proposed method with two popular use cases, one for estimating state changes and the other for identifying anomalous states, to confirm its feasibility.
[Two cases of stage IV breast cancer with severe hypercalcemia]. (2006)

Case 1: A 34-year-old woman,who had a right breast cancer with axillary lymph node metastasis and multiple bone metastases, was referred to our clinic. She developed paralysis of lower extremities and disorder of the bladder and rectum due to metastasis to the thoracic vertebra, and also had renal dysfunction due to severe hypercalcemia and hemorrhagic cystitis. Correcting the serum calcium level with intravenous infusion, elcatonin, pamidronate and betamethasone, she underwent radiation therapy for the vertebral metastasis. The first hormonal therapy (leuprorelin/exemestane) had been effective for about 4 months, however the second hormonal therapy (leuprorelin/tamoxifen) was not effective. Chemotherapy with paclitaxel (80 mg/m(2), day 1, 8, 15, every 4 weeks) brought about a stable general condition and a normal level of serum calcium with zoledronate in the ninth month of treatment. Case 2: A 32-year-old woman, who had a right breast cancer with multiple bone metastases and axillary and hilar lymph node metastases, came to our clinic, complaining of nausea due to severe hypercalcemia. After successful correction of hypercalcemia by the intravenous infusion and administration of elcatonin, pamidronate and dexamethasone, the hormonal therapy(goserelin/tamoxifen) caused rapid re-elevation of serum calcium and tumor marker, so that a tumor flare was suspected. After 3 cycles of EC therapy (EPI 90 mg/m(2), CPM 600 mg/m(2), every 3 weeks), 2 cycles of paclitaxel therapy (80 mg/m(2), day 1, 8, 15, every 4 weeks) brought about tumor reduction and the normal level of serum calcium. After 7 cycles of paclitaxel therapy,the hormonal therapy (goserelin/tamoxifen) proved effective for several months. To achieve tumor reduction and stabilize the serum calcium level, we need to start immediately the treatment of breast cancer with severe hypercalcemia, considering the general condition of the patient.
Intelligent Resource Allocation in Residential Buildings Using Consumer to Fog to Cloud Based Framework (2019)

In this work, a new orchestration of Consumer to Fog to Cloud (C2F2C) based framework is proposed for efficiently managing the resources in residential buildings. C2F2C is a three layered framework consisting of cloud layer, fog layer and consumer layer. Cloud layer deals with on-demand delivery of the consumer’s demands. Resource management is intelligently done through the fog layer because it reduces the latency and enhances the reliability of cloud. Consumer layer is based on the residential users and their electricity demands from the six regions of the world. These regions are categorized on the bases of the continents. Two control parameters are considered: clusters of buildings and load requests, whereas four performance parameters are considered: Request Per Hour (RPH), Response Time (RT), Processing Time (PT) and cost in terms of Virtual Machines (VMs), Microgrids (MGs) and data transfer. These parameters are analysed by the round robin algorithm, equally spread current execution algorithm and our proposed algorithm shortest job first. Two scenarios are used in the simulations: resource allocation using MGs and resource allocation using MGs and power storage devices for checking the effectiveness of the proposed work. The simulation results of the proposed technique show that it has outperformed the previous techniques in terms of the above-mentioned parameters. There exists a tradeoff in the PT and RT as compared to cost of VM, MG and data transfer.
Analysis of subsynchronous current propagation path of subsynchronous oscillation induced by renewable energy integrated to the power grid (2017)

This paper deals with operational parameter to study the propagation path of the subsynchronous current generated by the wind farm. First, the complex frequency domain operation parameter model of the transmission network, thermal power generator and other power system components are established. Then, the wind farm is taken as the subsynchronous current injection point and the subsynchronous current's propagation path is analysed according to the frequency impedance characteristic of the transmission network. The influences of the current frequency, the position of the wind farms and the structure of the AC system on the harmonic current distribution are analysed and studied with this method. Then the digital simulation method is used to demonstrate the conclusion drawn from the theoretical method. On the basis of the method proposed, the subsynchronous component shunt coefficient of the power system actual operation can be obtained initially.
The Design and Implementation of a Clinical Laboratory Quality Management System Model in a Research and Development Biotechnology Setting to Comply with Industry-specific Regulations (2015)

As a biotechnology company evolving from research and development into the more regulated arenas of FDA and USDA manufacturing requirements, the management team at Morphogenesis, Inc, recognized the necessity of implementing a comprehensive quality management system (QMS) that would facilitate the company’s …
Abscisic Acid May Play a Critical Role in the Moderating Effect of Epichloë Endophyte on Achnatherum inebrians under Drought Stress (2022)

Water scarcity is a major constraint that adversely affects plant development and growth. Abscisic acid (ABA) is a plant stress hormone that is rapidly synthesized and can induce stomatal closure to conserve water, thereby alleviating the drought stress of plants. The <i>Epichloë</i> endophyte enhances the drought tolerance of <i>Achnatherum inebrians</i> (drunken horse grass, DHG). To better understand how the <i>Epichloë</i> endophyte enhances drought tolerance, DHG plants without (EF) and with (EI), an <i>Epichloë</i> endophyte, were grown under 20% and 60% soil water conditions (SWC), and the leaves of the three treatments of EF and EI plants were sprayed with ABA solution (1 mg/L); fluridone (FLU), the ABA biosynthesis inhibitor solution (1 mg/L); and distilled water, respectively. Four-weeks later, the results indicated that the exogenous ABA application promoted plant growth, stomatal conductance, and photosynthetic rate, while the opposite effect occurred with plants sprayed with FLU. The differences between EI and EF plants in tiller number, height, chlorophyll content, stomata conductance, and photosynthetic rate were highest when sprayed with ABA. Thus, it is concluded that ABA might be involved in the moderating effect of <i>Epichloë</i> endophytes on DHG plants exposed to drought by maintaining growth and improving photosynthetic efficiency.
Editors' Choice—Epitaxial CVD Growth of Ultra-Thin Si Passivation Layers on Strained Ge Fin Structures (2018)

Epitaxially grown ultra-thin Si layers are often used to passivate Ge surfaces in the high-k gate module of (strained) Ge FinFET and Gate All Around devices. We use Si4H10 as Si precursor as it enables epitaxial Si growth at temperatures down to 330°C. C-V characteristics of blanket capacitors made on Ge virtual substrates point to the presence of an optimal Si thickness. In case of compressively strained Ge fin structures, the Si growth results in non-uniform and high strain levels in the strained Ge fin. These strain levels have been calculated for different shapes of the Ge fin and in function of the grown Si thickness. The high strain is the driving force for potential (unwanted) Ge surface reflow during Si deposition. The Ge surface reflow is strongly affected by the strength of the H-passivation during Si-capping and can be avoided by carefully selected process conditions.