gebhart/patrepeval huggingface dataset:
Report of the 2013 ICSE 1st international workshop on engineering mobile-enabled systems (MOBS 2013) (2013)

The 2013 1st International Workshop on Engineering Mobile-Enabled Systems (MOBS 2013) was held in conjunction with the 35th International Conference on Software Engineering, ICSE 2013, on May 25, 2013 in San Francisco, CA USA. MOBS 2013 brought together software engineering researchers from academia and industry, as well as practitioners, to share results and open issues in diverse areas of engineering mobile-enabled systems. The many discussions throughout the day resulted in the identification of three promising areas of research to address existing gaps and problems.
Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors. (1987)

Activated c-Ki-ras genes in liver tumors from rats exposed to the potent hepatocarcinogen aflatoxin B1 were analyzed to determine the nature of their activation by characterization of two c-Ki-ras alleles present in tumor-derived NIH 3T3 mouse transformants. Using selective hybridization of synthetic oligonucleotides to transformant DNA, we have determined that a single G X C to A X T base transition in either the first or second position of the 12th codon is associated with activation of the gene. Such mutations would lead to amino acid substitutions of aspartate or serine for glycine in the mutant proteins. To confirm these findings, we applied a technique for direct sequence analysis of a 90-base-pair region of the rat c-Ki-ras gene produced by primer-directed enzymatic amplification. Findings produced by this approach, which provides a convenient method to characterize mutations in multiple alleles without the necessity to clone individual genes, confirmed the presence and identity of the 12th codon mutations in the activated oncogene, as initially determined by the oligonucleotide hybridization technique.
Photocytotoxic cancer cell-targeting platinum(<scp>ii</scp>) complexes of glucose-appended curcumin and biotinylated 1,10-phenanthroline (2019)

Mixed-ligand platinum(ii) complexes, [Pt(phen)(pacac)](NO3) (1), [Pt(phen)(cur)](NO3) (2), [Pt(bt-phen)(cur)](NO3) (3) and [Pt(phen)(scur)](NO3) (4), where phen is 1,10-phenanthroline, bt-phen is 5-biotin-1,10-phenanthroline, pacac is 1,3-diphenyl-1,3-propanedioate anion, Hcur is curcumin and Hscur is diglucosylcurcumin, were prepared, characterized and their anticancer activity studied. Complexes 2-4 showed absorption bands within 410-430 nm (ε, 2.1 × 104 to 2.8 × 104 M-1 cm-1) in 10% DMSO-DPBS (Dulbecco's phosphate-buffered saline) and emission bands near 530 nm (λex = 410-430 nm) with a fluorescence quantum yield (ΦF) value of ∼0.02. The curcumin complexes showed stability over a study period of 48 h. The photocytotoxicity was studied using human cervical HeLa, human liver HepG2, human breast cancer MDA-MB 231 and human lung adenocarcinoma A549 cancer cells along with human immortalized lung epithelial HPL1D as normal cells. Complexes 2-4 showed apoptotic photo-induced cell death in light of wavelength 400-700 nm (IC50, half maximal inhibitory concentration: 6-28 μM) by reactive oxygen species (ROS), while remaining inactive in the dark (IC50: 43-95 μM). The selectivity of the complexes 3 and 4 was enhanced significantly towards the cancer cells than towards the normal cells, thus making them targeted photochemotherapeutic agents. The ROS formation and mode of cell death were studied from 2',7'-dichlorofluorescein diacetate (DCFDA) and annexin-V/FITC (fluorescein isothiocyanate)-PI assays, respectively. Preferential nuclear and mitochondrial localization was evidenced from inductively coupled plasma mass spectrometry (ICP-MS) studies.
Nitrocalix[4]arene als Verbindungen für die nichtlineare Optik zweiter Ordnung (1992)

Zur Frequenzverdopplung von 820‐nm‐laser‐Licht und damit prinzipiell zum Aufbau eines Blaulicht‐Lasers geeignet ist eine Reihe von Nitrocalix[4]arenen. Am aussichtsreichsten erscheint das Derivat 1 , das die größte Hyperpolarisierbarkeit und das größte Dipolmoment aufweist und das als Film in einer Polymermatrix über längere Zeiträume stabil ist. magnified image
B cells produce IL-27 to upregulate PD-L1 expression and promote breast cancer development (2019)

Abstract The host immune response can be corrupted by cancer cells during tumor progression. Here we showed that B lymphocytes played an important role in promoting murine breast cancer (BCa) development, as B cell-deficient mMT mice displayed virtually abrogated tumor growth from transplanted syngeneic ERa+ breast adenocarcinoma cells, concomitant with reduced PD-L1 expression and increased BCa cell death. In murine BCa tumors and tumor-associated lymph nodes, B cells were the major source of IL-27, a pleotropic cytokine with both pro- and anti-inflammatory functions. Deficiency in IL-27 expression specifically in B cells abolished the BCa tumor growth, showing that the effect of B cells in BCa development was mainly through IL-27 production, as likely induced by TLR ligands in the tumor microenvironment together with CD154 and IL-21 expressed by tumor-infiltrating CD4+ T cells. IL-27 treatment of BCa cells resulted in STAT1 and STAT3 phosphorylation, upregulated PD-L1 gene expression and enhanced cell growth. In addition, IL-27 induced activated B cells to express PD-L1 in vitro, consistent with high levels of PD-L1 expression by B cells in tumors. In humans, IL-27 receptor genes were highly expressed in the breast tissue, at levels comparable to those in lymphoid organs, and high IL-27 gene expression was associated with reduced survival in BCa patients, who displayed increased circulating IL-27 levels. Finally, IL-27 supported human BCa cell growth in the presence of tamoxifen, suggesting a role of IL-27 in the drug resistance. Thus, TLR-fueled IL-27 induction in B cells reinforces PD-L1 expression in the tumor environment to drive BCa cell growth and to promote generation of PD-L1hi B regulatory cells, leading to BCa tumor progression.
Controlled Protective Layer Based on Biphenyl Derivatives for Li-S Battery (2019)

International audience
Demonstration of the discrepancy between AT‐wave morphology on 12‐lead ECG and AT mechanism in scar‐related AT (2023)

The 12-lead electrocardiogram (ECG) is a fundamental modality to help determine the mechanism and the localization of atrial tachycardias (ATs). Although macroreentrant ATs and focal ATs typically show F-waves and discrete P-waves respectively on the 12-lead ECG, this is not universally the case in scar-related ATs.1<sup>,</sup> We present three cases clearly showing the discrepancy between the AT morphology on the 12-lead ECG and the AT-mechanism.
Instability of a Tandem Network and Its Propagation Under RED (2004)

The interaction between a random early detection (RED) gateway and transmission control protocol (TCP) connections has been shown to lead to a rich set of nonlinear phenomena in single bottleneck cases. We extend this work and study the interaction of TCP connections with RED gateways in a simple tandem network, using a nonlinear first-order discrete-time model. We demonstrate that the nonlinear behavior of TCP can result in both smooth and nonsmooth bifurcations, leading to chaos. We show that the instabilities can be induced at both bottlenecks by changing the system parameters only at one of the bottlenecks while fixing the parameters at the other, thus demonstrating the propagation of instability. Moreover, we show that locally sufficient conditions for stability based on single node analysis are not sufficient for global network stability.
Trial registration of abstracts from the American Society of Anesthesiologists Meetings 2010–2016: A review of prospective trial registration and selective outcome reporting (2022)

Mandatory prospective trial registration was introduced in 2005 to reduce publication bias and selective outcome reporting. In this study, we measured the proportion of prospective trial registration in randomized controlled trials in the anesthesia literature after this introduction, discrepancies between these trial protocols and subsequent publications, the association between being prospectively registered and reporting positive or negative results, and between being prospectively registered and achieving publication. We reviewed all abstracts from the American Society of Anesthesiologists annual meetings between 2010-2016 and included randomized controlled trials in humans. The abstract conclusions were scored as positive or negative according to predetermined definitions. We conducted a systematic search for trial registration and subsequent publication. Of the 9789 abstracts reviewed, 1070 abstracts were included. 222 (21%) of these abstracts had undergone prospective trial registration. 168/222 (76%) had a corresponding journal publication. 81(48%) had a major discrepancy between registration and publication. 149 (67%) of the abstracts with registration had positive outcomes compared with 616 (73%) of those without (Odds Ratio 0.77; 95% CI: 0.56 to 1.06; P = 0.105). Abstracts that had been registered were more likely to proceed to publication than those that had not (Odds Ratio 3.82; 95% CI 2.73 to 5.35; P < 0.001). The proportion of randomized controlled trials being prospectively registered in anesthesia remains low. Discrepancies between registry entries and corresponding journal publications are common. There was no association between prospective trial registration and subsequent positive outcomes. There was a strong association between prospective trial registration and the likelihood of progression to journal publication.
Remote Plasma‐Enhanced Metalorganic Chemical Vapor Deposition of Aluminum Oxide Thin Films (2008)

Abstract Aluminum oxide films were deposited using remote plasma‐enhanced metalorganic chemical vapor deposition from oxygen/trimethylaluminum mixtures. Initial studies by in situ spectroscopic ellipsometry demonstrated that the aluminum oxide films deposited at temperatures &lt;150 °C were porous. The low refractive index of 1.38 was found to increase to 1.52 under ambient conditions, due to ageing. In order to improve the film properties, two routes were explored. First, by increasing the substrate temperature films with a refractive index of 1.48 were obtained at 400 °C, accompanied by a strong decrease in OH concentration, as shown by infrared spectroscopy. Second, by applying an additional rf bias to the substrate the in situ refractive index increased up to 1.60 and the OH groups were quantitatively removed. magnified image
Muonium chemistry and spin dynamics in sulphur, modelling interstitial hydrogen (2011)

The nature of the elusive muonium centre in sulphur is re-examined in the light of new data on its level-crossing resonance and spin-lattice relaxation. The aim is to provide a model for the solid-state chemistry of interstitial hydrogen in this element, which is as yet unknown, as well as to solve one of the longest standing puzzles in μSR spectroscopy, namely the surprisingly strong depolarization of muons mimicking ion-implanted protons in this innocuous non-magnetic material. The paramagnetic muonium (and by inference hydrogen) centre is confirmed to have the character of a molecular radical, but with huge anisotropy at cryogenic temperatures and a striking shift of the resonance at ordinary temperatures, the hyperfine parameters appearing to collapse and vanish towards the melting point. New density-functional supercell calculations identify a number of possible structures for the defect centre, including a novel form of bond-centred muonium in a closed-ring S(8)Mu complex. Simulations of the spin dynamics and fits to the spectra suggest a dynamical equilibrium or chemical exchange between several configurations, with occupancy of the bond-centre site falling from unity at low cryogenic temperatures to zero near the melting point.
Synthesis of Substituted Trans-1,6-Dimethylbicyclo[4.3.0]-non-2-enes Using A Claisen Rearrangement of α-(Thioalkoxy) Esters (1989)

Abstract The Claisen rearrangement of α-(thioalkoxy)-esters provided access to substituted trans-1, 6-dimethylbicyclo[4.3.0]non-2-enes characteristic of the CD rings of the cucurbitanes.
Facile access to chiral 5-hydroxy-2-methylhexanoic acid lactones (pheromones of the carpenter Bee) (1981)

Alkyl 2-acyloxy-3-deoxy-D-erythro-hex-2-enopyranoside diesters are converted into the corresponding alkyl 2-C-methylene-3, 4-enopyranosides upon treatment with methylenetriphenylphosphorane and, depending on the nature of the aglycone, hydrogenation of the dienes can lead to 2-C-methyl derivatives with (R)- or (S)-stereochemistry, which can be easily converted into isomeric chiral 2,5-dimethylvalerolactones.
Characterization of the Effects of Aryl‐azido Compounds and UVA Irradiation on the Viral Proteins and Infectivity of Human Immunodeficiency Virus Type 1 (2010)

Hydrophobic UV-activatable compounds have been shown to partition into the hydrophobic region of biological membranes to selectively label transmembrane proteins, and to inactivate enveloped viruses. Here, we analyze various UV-activatable azido- and iodo-based hydrophobic compounds for their ability to inactivate a model-enveloped virus, human immunodeficiency virus (HIV-1 MN). Treatment of HIV-1 with 1,5-diazidonapthalene (DAN), 1-iodo, 5-azidonaphthalene (INA), 1-azidonaphthalene (AzNAP) or 4,4'-diazidobiphenyl (DABIPH) followed by UVA irradiation for 2 min resulted in complete viral inactivation, whereas treatment using analogous non-azido-containing controls had no effect. Incorporation of an azido moiety within these hydrophobic compounds to promote photoinduced covalent reactions with proteins was found to be the primary mechanism of viral inactivation for this class of compounds. Prolonged UVA irradiation of the virus in the presence of these azido compounds resulted in further modifications of viral proteins, due to the generation of reactive oxygen species, leading to aggregation as visualized via Western blot analysis, providing additional viral modifications that may inhibit viral infectivity. Furthermore, inactivation using these compounds resulted in the preservation of surface antigenic structures (recognized by neutralizing antibodies b12, 2g12 and 4e10), which is favorable for the creation of vaccines from these inactivated virus preparations.
Topographic optical profilometry of steep slope micro-optical transparent surfaces (2015)

Optical profilometers based on light reflection may fail at surfaces presenting steep slopes and highly curved features. Missed light, interference and diffraction at steps, peaks and valleys are some of the reasons. Consequently, blind areas or profile artifacts may be observed when using common reflection micro-optical profilometers (confocal, scanning interferometers, etc…). The Topographic Optical Profilometry by Absorption in Fluids (TOPAF) essentially avoids these limitations. In this technique an absorbing fluid fills the gap between a reference surface and the surface to profile. By comparing transmission images at two different spectral bands we obtain a reliable topographic map of the surface. In this contribution we develop a model to obtain the profile under micro-optical observation, where high numerical aperture (NA) objectives are mandatory. We present several analytical and experimental results, validating the technique's capabilities for profiling steep slopes and highly curved micro-optical surfaces with nanometric height resolution.
Dose schedule evaluation of metoclopramide as a potentiator of cisplatin and carboplatin treatments of xenografted squamous cell carcinomas of the head and neck (1991)

The potentiating effect of metoclopramide on the tumor growth inhibition of cisplatin has been studied on human squamous cell carcinomas xenografted to nude mice. In this system, the optimal time interval for intraperitoneal administration of metoclopramide was 8 h after intraperitoneal administration of cisplatin. The optimal single dose level of metoclopramide in this study was 2 mg/kg. Metoclopramide enhanced the cytotoxic effect of cisplatin at all cisplatin doses tested between 2.5 and 7.5 mg/kg body weight. Under experimental conditions that gave optimal sensitization of cisplatin-induced cytotoxicity, there was no potentiation of the cytotoxic effect with metoclopramide in combination with carboplatin. There is great similarity in the cytotoxic action of cisplatin and carboplatin, with the main difference being a much slower rate of formation of DNA crosslink formation following carboplatin exposure. Hence the data reported here support an important role for the kinetics of formation and reparability of DNA damage as part of the mechanism of metoclopramide sensitization of platinum-containing drugs.
Variation in nutrient digestibility and energy intake are key contributors to differences in postweaning growth performance1 (2014)

Pig weight variation represents an important source of lost production and profitability in the swine industry. To date, few experiments have classified how pigs of the same age but different weight utilize dietary energy and nutrients. The objective of this experiment was to characterize how pigs with varying weaning weights (WW) and postweaning growth performance differ in apparent total tract digestibility (ATTD) of energy or nutrient digestibility or energy utilization. Ninety-six barrows weaned at 18 to 22 d of age were selected from 960 to represent the 10% of the lightest (LWW), median (MWW), and heaviest (HWW) at weaning (n = 32 pigs per WW category). Pigs were housed in metabolism crates for a 5-d acclimation period and a 27-d study and fed ad libitum quantities of a common diet containing titanium dioxide as an indigestible marker. Fecal grab samples and total urine were collected during a 3-d collection period at the beginning and end of the experiment. After the experiment, pigs within each WW category were further classified into the 33% slowest, median, or fastest ADG categories. This resulted in a total of 9 treatments in a nested design. Data were analyzed using the GLIMMIX procedure of SAS. There were no differences in ATTD according to WW at the beginning or end of the experiment, or when ADG was nested within WW at the beginning of the experiment. However, the ATTD of DM, GE, N, and ash, as well as the related DE, ME, and NE content, were greatest (P < 0.01) in the median ADG categories of pigs at the end of the experiment. Energy intake increased with increasing WW (P < 0.001; NE intake = 1.40, 1.64, and 1.89 Mcal/d for pigs from the LWW, MWW, and HWW, respectively). However, the ratio of calculated to actual ME intake was lower in LWW pigs than HWW pigs (P = 0.04; 1.03 and 1.10 for LWW and HWW pigs, respectively). When ADG was nested within WW category, both increasing WW and ADG increased (P < 0.001) energy intake, utilization, and efficiency for gain, energy retained as tissue, and retained GE. The calculated to actual ME intake ratio differed (P < 0.03), supposedly because of differences in thermoneutrality, and therefore maintenance requirements. Reduced postweaning ADG appears to be driven by a combination of poor nutrient digestibility, energy intake, and, possibly, cold stress, which may provide avenues for more directed pig management strategies in the future to minimize variation within a group.
Harnessing coupler-induced localized backscattering for enhanced fast and slow light performances in a traveling wave microresonator (2010)

We present an analytical study on the effects of coupler-induced localized backscattering (CILB) on the nature of superluminal and subliminal propagations in a traveling wave microresonator (TWMR). It is found that in the weak CILB regime, the flexibility to control the light propagation velocity is improved, and fast and slow light with high output power can be generated for a TWMR with a small net optical gain.
Mitogenic response of human thymocytes: identification of functional Ca2+-dependent and independent signals. (1986)

In contrast to peripheral blood mononuclear cells (PBMC), human thymocytes do not exhibit a proliferative response to the T cell mitogens phytohaemagglutinin (PHA), concanavalin A (Con A), or Staphylococcal protein A (SPA). In thymocytes and PBMC, Con A and PHA induce increases in free cytosolic calcium concentrations [( Ca2+]i). Since both Con A and PHA induce similar increases in [Ca2+]i in thymocytes and PBMC, the absence of thymocyte proliferation was not due to an inability to induce an increase in [Ca2+]i. The lack of proliferative response was secondary to the failure of the mitogens to induce interleukin 2 (IL-2) production. Incubation of mitogen-treated thymocytes with phorbol esters reconstituted IL-2 production and the proliferative response indicating that the cells were indeed activated by the mitogens. Similarly, addition of exogenous recombinant IL-2 also induced mitogen-treated thymocytes to proliferate. This IL-2-dependent proliferation established that SPA, Con A, and PHA triggered the expression of biologically active IL-2 receptors. Since an increase in [Ca2+]i is a prerequisite, and possibly a trigger, for IL-2 production, the failure of PHA, Con A, or SPA to result in thymocyte proliferation may be due to an inability of thymocytes to respond to increases in [Ca2+]i with subsequent IL-2 production.
Guided Feature Labeling for Budget-Sensitive Learning Under Extreme Class Imbalance (2010)

Extreme class skew is a hurdle in many machine learning tasks. In such skewed settings, traditional methods for procuring labeled examples, including random sampling and active learning, are often ineffective— they struggle to find representative minority examples. The framework of Dual Supervision, which incorporates feature-based background information into traditional supervised learning, provides one avenue to combat this problem. However, active learning for feature information (feature labeling), like active learning, is often not resilient to extreme class skew. In this work, we present an alternative to active feature labeling, Guided Feature Labeling. In this paradigm, human domain experts are tasked with finding classindicative features given a description of a class. This work explores different data acquisition costs, and demonstrates that under certain conditions, Guided Feature Labeling does indeed offer high performance models at a far lower budget than complementary active labeling approaches. 1.
Frequency-doubled DBR-tapered diode laser for direct pumping of Ti:sapphire lasers generating sub-20 fs pulses (2011)

For the first time a single-pass frequency doubled DBR-tapered diode laser suitable for pumping Ti:sapphire lasers generating ultrashort pulses is demonstrated. The maximum output powers achieved when pumping the Ti:sapphire laser are 110 mW (CW) and 82 mW (mode-locked) respectively at 1.2 W of pump power. This corresponds to a reduction in optical conversion efficiencies to 75% of the values achieved with a commercial diode pumped solid-state laser. However, the superior electro-optical efficiency of the diode laser improves the overall efficiency of the Ti:sapphire laser by a factor > 2. The optical spectrum emitted by the Ti:sapphire laser when pumped with our diode laser shows a spectral width of 112 nm (FWHM). Based on autocorrelation measurements, pulse widths of less than 20 fs can therefore be expected.
Optical magnetic response of upright plasmonic molecules in 3D metamaterial (2011)

An array of fabricated U-shaped split-ring resonators shows a profound response to the magnetic field of light incident normal to the sample.