gebhart/patrepeval huggingface dataset:
Effect of Adding UV Absorbers Embedded in Carbonate Calcium Templates Covered with Light Responsive Polymer into a Clear Wood Coating (2018)

The limited durability of clear coatings is a major issue for the coating and wood industry. The addition of organic UV absorbers improves coating resistance by the absorption and the conversion of the UV radiation into harmless heat. Organic UVAs are prone to degradation and can migrate in the binder of coatings. In this study, commercial UVAs and HALS have been entrapped into CaCO3 templates coated with stimuli responsive polymers. Microspheres were incorporated into a clear acrylic water-based coating formulation. The formulation was applied on glass and wood panels and was placed into an artificial UV chamber. This study presents a comparison between the aesthetic behavior of coating formulations with free and encapsulated commercial UVAs and HALS during the accelerated ageing test. Encapsulation of UVAs was confirmed by XPS and TGA analysis. Results have shown that the coating’s aesthetic was slightly improved when using the encapsulated products.
6E-2 Surface Acoustic Wave Trapping in a Periodic Array of High Aspect Ratio Electrodes (2006)

Surface acoustic wave transduction by the use of an interdigital transducer (IDT) is a well-known and widespread technique. However, a usual IDT makes use of electrodes with limited heights, so that surface mode properties do not differ appreciably from those of a free or a fully metalized surface. We proposed previously [V. Laude et aL, J. Appl. Phys. 90, 2492 (2001)] a theoretical analysis of the transduction of surface acoustic waves (SAW) under a metallic array of electrodes with a large aspect ratio on a piezoelectric substrate, whereby allowing the electrode height to become larger than one wavelength. We here report on the experimental observation of the multimode character of SAW propagation under a periodic array of electrodes. We also obtain experimentally the explicit dependence of the SAW velocities as a function of the electrode height. In that purpose, we fabricated interdigital transducers on the Y+128 cut of lithium niobate using electroplating of nickel. The slightly pyramidal electrodes are up to five times higher than wide. The variation of the resonances frequencies of the various surface modes was obtained experimentally. Up to a 10-fold slowing of surface waves is observed, with the phase velocity dropping from 4000 m/s down to 450 m/s. The comparison with a theory based on a coupled finite-element boundary-element-method is excellent
Sulfatide in health and disease. The evaluation of sulfatide in cerebrospinal fluid as a possible biomarker for neurodegeneration (2021)

Sulfatide (3-O-sulfogalactosylceramide, SM4) is a glycosphingolipid, highly multifunctional and particularly enriched in the myelin sheath of neurons. The role of sulfatide has been implicated in various biological fields such as the nervous system, immune system, host-pathogen recognition and infection, beta cell function and haemostasis/thrombosis. Thus, alterations in sulfatide metabolism and production are associated with several human diseases such as neurological and immunological disorders and cancers. The unique lipid-rich composition of myelin reflects the importance of lipids in this specific membrane structure. Sulfatide has been shown to be involved in the regulation of oligodendrocyte differentiation and in the maintenance of the myelin sheath by influencing membrane dynamics involving sorting and lateral assembly of myelin proteins as well as ion channels. Sulfatide is furthermore essential for proper formation of the axo-glial junctions at the paranode together with axonal glycosphingolipids. Alterations in sulfatide metabolism are suggested to contribute to myelin deterioration as well as synaptic dysfunction, neurological decline and inflammation observed in different conditions associated with myelin pathology (mouse models and human disorders). Body fluid biomarkers are of importance for clinical diagnostics as well as for patient stratification in clinical trials and treatment monitoring. Cerebrospinal fluid (CSF) is commonly used as an indirect measure of brain metabolism and analysis of CSF sulfatide might provide information regarding whether the lipid disruption observed in neurodegenerative disorders is reflected in this body fluid. In this review, we evaluate the diagnostic utility of CSF sulfatide as a biomarker for neurodegenerative disorders associated with dysmyelination/demyelination by summarising the current literature on this topic. We can conclude that neither CSF sulfatide levels nor individual sulfatide species consistently reflect the lipid disruption observed in many of the demyelinating disorders. One exception is the lysosomal storage disorder metachromatic leukodystrophy, possibly due to the genetically determined accumulation of non-metabolised sulfatide. We also discuss possible explanations as to why myelin pathology in brain tissue is poorly reflected by the CSF sulfatide concentration. The previous suggestion that CSF sulfatide is a marker of myelin damage has thereby been challenged by more recent studies using more sophisticated laboratory techniques for sulfatide analysis as well as improved sample selection criteria due to increased knowledge on disease pathology.
HYDRODYNAMICS OF THREE-PHASE AIRUFT(TPAL) REACTORS USING VISCOUS FLUIDS (1998)

Abstract This paper describes a series of experiments undertaken to evaluate the influence of liquid viscosities of up to 17mPason the hydrodynamic behaviour of an external-loop TPAL reactor. Mixtures of glycerol and water were used as model viscous Newtonian fluids. The primary effects of the increase in viscosity were to reduce the terminal settling velocity of the solids, and to increase the system head losses. Empirical expressions describing the gas holdups in the riser and downcomer were obtained from the data. These have been used to generate solutions for a mathematical model describing the system, which enable the prediction of the reactor stalling point and the magnitude of the liquid recirculation velocity (U LR) for a given gas flowrate. Experimental measurements of U LR have been compared with predicted U LR values obtained using the mathematical model, and there is good agreement between the two.
ChemInform Abstract: Synthesis of 1,1‐Bisphosphono‐2‐aza‐1,3‐dienes, a New Class of Electron‐Deficient Azadienes. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Data from Direct Inhibition of Retinoblastoma Phosphorylation by Nimbolide Causes Cell-Cycle Arrest and Suppresses Glioblastoma Growth (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Classical pharmacology allows the use and development of conventional phytomedicine faster and more economically than conventional drugs. This approach should be tested for their efficacy in terms of complementarity and disease control. The purpose of this study was to determine the molecular mechanisms by which nimbolide, a triterpenoid found in the well-known medicinal plant &lt;i&gt;Azadirachta indica&lt;/i&gt;, controls glioblastoma growth.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Using &lt;i&gt;in vitro&lt;/i&gt; signaling, anchorage-independent growth, kinase assays, and xenograft models, we investigated the mechanisms of its growth inhibition in glioblastoma.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; We show that nimbolide or an ethanol soluble fraction of &lt;i&gt;A. indica&lt;/i&gt; leaves (Azt) that contains nimbolide as the principal cytotoxic agent is highly cytotoxic against glioblastoma multiforme &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. Azt caused cell-cycle arrest, most prominently at the G&lt;sub&gt;1&lt;/sub&gt;–S stage in glioblastoma multiforme cells expressing &lt;i&gt;EGFRvIII&lt;/i&gt;, an oncogene present in about 20% to 25% of glioblastoma multiformes. Azt/nimbolide directly inhibited CDK4/CDK6 kinase activity leading to hypophosphorylation of the retinoblastoma protein, cell-cycle arrest at G&lt;sub&gt;1&lt;/sub&gt;—S, and cell death. Independent of retinoblastoma hypophosphorylation, Azt also significantly reduced proliferative and survival advantage of glioblastoma multiforme cells &lt;i&gt;in vitro&lt;/i&gt; and in tumor xenografts by downregulating Bcl2 and blocking growth factor-induced phosphorylation of Akt, extracellular signal-regulated kinase 1/2, and STAT3. These effects were specific because Azt did not affect mTOR or other cell-cycle regulators. &lt;i&gt;In vivo&lt;/i&gt;, Azt completely prevented initiation and inhibited progression of glioblastoma multiforme growth.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our preclinical findings demonstrate nimbolide as a potent anti-glioma agent that blocks cell cycle and inhibits glioma growth &lt;i&gt;in vitro&lt;/i&gt; and in &lt;i&gt;vivo&lt;/i&gt;. &lt;i&gt;Clin Cancer Res; 20(1); 199–212. ©2013 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A novel test technology for a standardized stability control system and its test platform (2022)

The stability control system is the second defense line of the power system, and the test before applying the stability control system is a key link to ensure the performance of the system. Since the configuration and strategy of the standardized stability control system are related through the setting of fixed value items, it is necessary to comprehensively consider the coupling between different application scenarios, different operation modes, and different stability control strategies to verify the functions of each device. Starting from the design concept and function of the standardized stability control system, this paper introduces the test scheme of the standardized stability control system from three aspects: monomer test, static test, and strategy verification test. Besides, the test platform of the stability control system based on RTDS is built, which lays the foundation for the stability control test and ensures that the standardized stability control system meets the requirements of regulations and specifications.
Communication lifting: fixed point computation for parallelism (1995)

Abstract Communication lifting is a program transformation that can be applied to a synchronous process network to restructure the network. This restructuring in theory improves sequential and parallel performance. The transformation has been formally specified and proved correct and it has been implemented as an automatic program transformation tool. This tool has been applied to a small set of programs consisting of synchronous process networks. For these networks communication lifting generates parallel programs that do not require locking. Measurements indicate performance gains in practice both with sequential and parallel evaluation. Communication lifting is a worthwhile optimization to be included in a compiler for a lazy functional language.
Thickness dependence of interfacial magneto-optic effects in Pt/Co multilayers (1998)

Spectroscopic ellipsometry and magneto-optic Kerr effects are measured on Pt/Co multilayers with a series of Co layer thicknesses from 0.08 to 1 nm. An electromagnetic theory of multilayered structures allows regression analysis fits between acquired data and parameter dependent model analysis. Recently, we determined the single layer Co magneto-optic Voigt parameter and found that it depends on Co layer thickness. In the present work, we report an in-depth study of interfacial magneto-optic effects for a large number of Pt/Co multilayer samples. Kerr rotation and ellipticity were measured over the spectral range from 200 to 1700 nm. Voigt parameters of the magnetic layers for these Pt/Co multilayer samples with different thicknesses were compared, and the Pt–Co interface thicknesses were determined in terms of the material dielectric tensor.
Retina, Third Edition. (2001)

Equi, Robert A. MD; Phillips, Stephen J. MD; Walsh, Alexander C. MDEditor(s): Wilkinson, C. P. MD Author Information
Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif (2015)

The corticotropin-releasing hormone receptor type 1 (CRHR1) plays an important role in orchestrating neuroendocrine, behavioral, and autonomic responses to stress. To identify molecules capable of directly modulating CRHR1 signaling, we performed a yeast-two-hybrid screen using the C-terminal intracellular tail of the receptor as bait. We identified several members of the membrane-associated guanylate kinase (MAGUK) family: postsynaptic density protein 95 (PSD95), synapse-associated protein 97 (SAP97), SAP102 and membrane associated guanylate kinase, WW and PDZ domain containing 2 (MAGI2). CRHR1 is co-expressed with the identified MAGUKs and with the additionally investigated PSD93 in neurons of the adult mouse brain and in primary hippocampal neurons, supporting the probability of a physiological interaction in vivo. The C-terminal PDZ (PSD-95, discs large, zona occludens 1) binding motif of CRHR1 is essential for its physical interaction with MAGUKs, as revealed by the CRHR1-STAVA mutant, which harbors a functionally impaired PDZ binding motif. The imitation of a phosphorylation at Thr413 within the PDZ binding motif also disrupted the interaction with MAGUKs. In contrast, distinct PDZ domains within the identified MAGUKs are involved in the interactions. Expression of CRHR1 in primary neurons demonstrated its localization throughout the neuronal plasma membrane, including the excitatory post synapse, where the receptor co-localized with PSD95 and SAP97. The co-expression of CRHR1 and respective interacting MAGUKs in HEK293 cells resulted in a clustered subcellular co-localization which required an intact PDZ binding motif. In conclusion, our study characterized the PDZ binding motif-mediated interaction of CRHR1 with multiple MAGUKs, which directly affects receptor function.
CRAGE-CRISPR facilitates rapid activation of secondary metabolite biosynthetic gene clusters in bacteria (2021)

With the advent of genome sequencing and mining technologies, secondary metabolite biosynthetic gene clusters (BGCs) within bacterial genomes are becoming easier to predict. For subsequent BGC characterization, clustered regularly interspaced short palindromic repeats (CRISPR) has contributed to knocking out target genes and/or modulating their expression; however, CRISPR is limited to strains for which robust genetic tools are available. Here we present a strategy that combines CRISPR with chassis-independent recombinase-assisted genome engineering (CRAGE), which enables CRISPR systems in diverse bacteria. To demonstrate CRAGE-CRISPR, we select 10 polyketide/non-ribosomal peptide BGCs in Photorhabdus luminescens as models and create their deletion and activation mutants. Subsequent loss- and gain-of-function studies confirm 22 secondary metabolites associated with the BGCs, including a metabolite from a previously uncharacterized BGC. These results demonstrate that the CRAGE-CRISPR system is a simple yet powerful approach to rapidly perturb expression of defined BGCs and to profile genotype-phenotype relationships in bacteria.
Non-Interactive Multi-Client Searchable Encryption: Realization and Implementation (2020)

In this article, we introduce a new mechanism for constructing multi-client searchable encryption (SE). By tactfully leveraging the RSA-function, we propose the first multi-client SE protocol that successfully avoids per-query interaction between data owner and client. Therefore, our approach significantly reduces the communication cost by eliminating the need for data owner to authorize client queries at all times. To be compatible with the RSA-based approach, we also present a deterministic and memory-efficient &#x2018;keyword to prime&#x2019; hash function, which may be of independent interest. Further, to improve efficiency, we put forward a more generic construction from set-constrained PRFs. The construction not only inherits the merits of our first protocol, but also achieves an enhanced security (against untrusted clients), where colluding attack among clients is also taken into account. Both protocols are instantiated via the recent representative SE protocol by Cash <i>et al.</i> with the support of boolean queries. At last, we implement our proposed protocols and comprehensively evaluate their performance to demonstrate their practicability and scalability.
Decolourisation and treatment of pulp and paper mill effluent by lignin‐degrading <i>Bacillus</i> sp. (2007)

Abstract Three lignin‐degrading bacterial strains, identified as Paenibacillus sp., Aneurinibacillus aneurinilyticus and Bacillus sp. have been examined for the treatment of pulp and paper mill effluent. The results of this study revealed that all three bacterial strains effectively reduced colour (39–61%), lignin (28–53%), biochemical oxygen demand (BOD) (65–82%), chemical oxygen demand (COD) (52–78%) and total phenol (64–77%) within six days of incubation. However, the highest reduction in colour (61%), lignin (53%), BOD (82%) and COD (78%) was recorded by Bacillus sp. while, maximum reduction in total phenol (77%) was recorded with Paenibacillus sp. treatment. Significant reduction in colour and lignin content by these bacterial strains was observed after two days of incubation, indicating that bacterium initially utilized growth supportive substrates and subsequently chromophoric compounds thereby reducing lignin content and colour in the effluent. The total ion chromatograph (TIC) of compounds present in the ethyl acetate extract of control and bacterial treated samples revealed the formation of several lignin‐related aromatic compounds. The compounds identified in extracts of treated samples by Paenibacillus sp were t ‐cinnamic acid and ferulic acid, while 3‐hydroxy‐4‐methoxyphenol, vanillic acid and vanillin acid by A. aneurinilyticus and gallic acid and ferulic acid by Bacillus sp. respectively indicating the degradation of lignin present in the effluent. The identified compounds obtained after different bacterial treatments were found to be strain‐specific. Among these identified compounds, ferulic acid, vanillic acid and vanillin could have immense value for their use in preservatives and in the food flavour industry. Copyright © 2007 Society of Chemical Industry
Optimal Sensing Disruption for a Cognitive Radio Adversary (2010)

Spectrum sensing vulnerabilities in cognitive radio (CR) networks are being actively investigated, where most research focuses on mechanisms that deal with possible attacks without examining optimal sensing disruption strategies. This paper addresses the optimal design and analysis of a power-limited intelligent adversary to a CR network. The adversary targets unused bands and puts energy into them so that the number of unused bands appears reduced to secondary users. This is called sensing disruption. The optimal disruption strategy is obtained by maximizing the average number of false detections under the adversary's power constraint. It is shown that, for a CR network where energy detection is utilized by secondary users, the optimal sensing disruption strategy for noise spoofing for a CR adversary is equal-power partial-band spoofing. Numerical results and analyses of the optimal sensing disruption are provided.
A test point insertion method to reduce the number of test patterns (2003)

The recent advances in semiconductor integration technology have resulted in an increasing number of the test lengths of full scan designed LSI. This paper presents a test point insertion method for reducing test patterns of full scan designed LSI. In our method, test points are inserted based on improved fault detection probability and value assignment probability such that test patterns are efficiently compacted. Experimental results for some practical designs show that the rate of test pattern compaction ranges from 31% to 65%. Those results also prove that our method is very effective for reducing the number of test patterns.
Investigation of Surface Oxide Layer Structure to Improve Durability of Stainless Steels Under Humidified Hydrogen (2023)

Durability of low cost stainless steels, selected from the materials widely used in other applications, was investigated under humidified hydrogen of SOFC anode condition. JIS SUS430J1L exhibited higher resistance for water oxidation. The feature came mainly from the thin Cr-rich oxide layer covering the alloy uniformly with little defects or segregations. Under humidified H 2 at 700 o C, Mn migrated outward and the morphology changed. Durability of the alloy seems to depend on the inner side of the surface oxide layer. Although the Cr-rich oxide layer blocked outward diffusion of metal ions, the layer could not block inward diffusion of oxygen ion completely. Improvement of the durability is possible by controlling the thickness of the surface oxide layer by the pre-heat-treatment.
Data from Reconstitution of Human Telomerase Reverse Transcriptase Expression Rescues Colorectal Carcinoma Cells from &lt;i&gt;In vitro&lt;/i&gt; Senescence: Evidence against Immortality as a Constitutive Trait of Tumor Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Although &lt;i&gt;in vitro&lt;/i&gt; establishment of new colorectal carcinoma (CRC) cell lines is an infrequent event, we have observed that primary cultures of CRC can be repeatedly and reproducibly initiated following &lt;i&gt;in vitro&lt;/i&gt; plating of tumor-derived epithelial cells. These cultures, however, usually display a short life span as they undergo a limited number of cell passages before entering a state of irreversible growth arrest. In this study, we show that short-lived CRC primary cultures lack constitutive telomerase activity and undergo a senescence process characterized by progressive telomere shortening. Moreover, transduction of these cells with a retroviral vector encoding human telomerase reverse transcriptase (hTERT) is sufficient to reconstitute telomerase activity and allow immortalization. Detailed molecular characterization of hTERT-immortalized CRC cell lines confirms their individual tumor origin by showing expression of colonic epithelial differentiation markers, such as cytokeratin-20 (CK20), full match with class I and class II human leukocyte antigen genotyping of autologous B-lymphoblastoid cells, and presence of somatic mutations in key cancer genes (&lt;i&gt;KRAS2&lt;/i&gt;, &lt;i&gt;APC&lt;/i&gt;) identical to those of the corresponding autologous original tumor tissues. Moreover, functional characterization of hTERT-immortalized CRC cell lines shows that they have a transformed phenotype, being able to form colonies in soft agar and tumors in severe combined immunodeficient mice. Most interestingly, immunohistochemical analysis of original tumor tissues indicates that short-lived CRC primary cultures, although hTERT-negative &lt;i&gt;in vitro&lt;/i&gt;, derive from hTERT-positive tumors. Taken together, our data show that, in a least subset of CRC, biochemical pathways involved in maintenance of telomere length, such as telomerase, are not activated in a constitutive way in all tumor cells.&lt;/p&gt;&lt;/div&gt;
Infant Feeding, Gut Permeability, and Gut Inflammation Markers (2023)

Higher intake of breast milk may contribute to higher calprotectin concentration, whereas several complementary foods may decrease gut permeability and concentrations of calprotectin and HBD-2 in infant gut.
Figure S2 from Clinical Utility of Prospective Molecular Characterization in Advanced Endometrial Cancer (2023)

&lt;p&gt;Comparison of most recurrently mutated genes in MSKCC vs. TCGA cohort&lt;/p&gt;