gebhart/patrepeval huggingface dataset:
Root Cause Analysis of Torsional and Lateral Vibrations on a Compressor Test Rig (2020)

Abstract In this case study an extensive root cause analysis was performed on a compressor test rig following the observation of unexpected high amplitude vibrations during the rig commissioning. Typically, the location and the frequency of an observed vibration is not enough to pinpoint the cause of the behavior in a system with multiple components. The test rig comprising of an electric motor, gearbox and compressor rotor may be subject to rotordynamics, torsional dynamics, mechanical eigenfrequencies and fluid dynamics in the compressor. In order to understand the source of the vibrations observed at the gearbox, lateral vibrations of the casing and torsional vibrations of the rotor were measured simultaneously. In parallel, the system was modeled in MADYN 2000 in order to match the observations with theoretical torsional eigenmodes of the drivetrain. The modeling of the system resulted in a torsional eigenfrequency lying within 10% of the observed gearbox vibration, making it a viable candidate to excite gearbox vibrations through a varying torque. To be able to measure this mode shape, a temporal measurement setup for torsional vibrations had to be installed. The measurements of the test campaign revealed that a torsional resonance is indeed present at the frequency of the observed vibrations. However, a lack of coherence between the torsional and lateral vibrations suggests that the torsional resonance is not the root cause of the gearbox vibrations. Two separate resonances were observed as the gear mesh frequency crossed the torsional eigenfrequency and the observed high amplitude gearbox vibration. Evidence of a structural eigenfrequency of the gearbox was found through an impact test. Although the torsional resonance is ruled out as the root cause, it is presumed that the two resonances do experience a positive coupling, causing the particularly high gearbox vibrations.
Comparison of adaptive and innate immune responses induced by licensed vaccines for human papillomavirus (2014)

Two HPV virus-like particle (VLP) vaccines, HPV-16/18 (GlaxoSmithKline, Cervarix®) and HPV-6/11/16/18 (Merck, Gardasil®), are currently licensed in the United States. Given the similar antigenic content but different adjuvant formulations in the 2 vaccines, they provide an efficient method for evaluating adjuvants and comparing the kinetics of the innate and adaptive immune responses. We randomized women to receive either Cervarix® or Gardasil®, followed 6 month vaccination delivery schedules per manufacturer's recommendations, and analyzed the humoral immune response, T cell response, and circulating plasma cytokine levels in response to vaccination. Cervarix® recipients had higher anti-HPV-16 antibody and neutralization titers at month 7, and elevated anti-HPV-18 antibody and neutralization titers at months 7 and 12. Antibody avidity was similar for the 2 vaccines. HPV-31 was the only phylogenetically related non-vaccine HPV type, for which there is evidence of cross-protection, to be cross-neutralized and only in response to Cervarix®. Comparing CD4+ T cell cytokine responses at month 12, there was a trend of increased levels of IL-2 and TNF-α in the Cervarix® groups versus the Gardasil® groups that was consistent across all 4 tested HPV types (16/18/33/45). Elevated levels of circulating plasma cytokine/chemokines were observed post first vaccination in Gardasil® recipients and proinflammatory cytokines were elevated following 1st and 3rd Cervarix® vaccinations. Cervarix® and Gardasil® are both highly immunogenic vaccines. Higher antibody levels and CD4 T cell responses were achieved with Cervarix® after 3 doses, although similar affinity maturation was measured for the 2 vaccines. The clinical implications of the differences in immune responses are unknown.
Pyrolysis of Alkyl Acetates. A Radical Pathway for the Formation of Minor Products (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrolysis of Alkyl Acetates. A Radical Pathway for the Formation of Minor ProductsBuchang Shi, Ying Ji, Hossein A. Dabbagh, and Burtron H. DavisCite this: J. Org. Chem. 1994, 59, 4, 845–849Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://pubs.acs.org/doi/10.1021/jo00083a028https://doi.org/10.1021/jo00083a028research-articleACS PublicationsRequest reuse permissionsArticle Views223Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Ligand Binding in the Catalytic Antibody 17E8. A Free Energy Perturbation Calculation Study (1997)

We present free energy calculations on the Michaelis complexes of the catalytic antibody 17E8 with two substrates, which differ only in their side chains. Replacing a -CH2- group with a -S- increases KM by a factor of about 5−8. This corresponds to a free energy “preference” for the -CH2- ligand of about 0.9−1.3 kcal/mol. The calculations semiquantitatively reproduce the experimental free energies and show that the preference for a -CH2- over a -S- is mainly due to the more favorable solvation free energy in the unbound form of the molecule.
Solitaire Flow Restoration Thrombectomy for Acute Ischemic Stroke (2013)

Our study shows that a variety of other endovascular approaches are used in conjunction with Solitaire FR in actual practice in the United States. Early postmarket results suggest that Solitaire FR is an effective tool for endovascular treatment of acute ischemic stroke.
Commitment and oncogene-induced plasticity of human stem cell-derived pancreatic acinar and ductal organoids (2021)

The exocrine pancreas, consisting of ducts and acini, is the site of origin of pancreatitis and pancreatic ductal adenocarcinoma (PDAC). Our understanding of the genesis and progression of human pancreatic diseases, including PDAC, is limited because of challenges in maintaining human acinar and ductal cells in culture. Here we report induction of human pluripotent stem cells toward pancreatic ductal and acinar organoids that recapitulate properties of the neonatal exocrine pancreas. Expression of the PDAC-associated oncogene GNAS<sup>R201C</sup> induces cystic growth more effectively in ductal than acinar organoids, whereas KRAS<sup>G12D</sup> is more effective in modeling cancer in vivo when expressed in acinar compared with ductal organoids. KRAS<sup>G12D</sup>, but not GNAS<sup>R201C</sup>, induces acinar-to-ductal metaplasia-like changes in culture and in vivo. We develop a renewable source of ductal and acinar organoids for modeling exocrine development and diseases and demonstrate lineage tropism and plasticity for oncogene action in the human pancreas.
Insights into the Effects of Cancer Associated Mutations at the UPF2 and ATP-Binding Sites of NMD Master Regulator: UPF1 (2019)

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that recognizes post-transcriptionally abnormal transcripts and mediates their degradation. The master regulator of NMD is UPF1, an enzyme with intrinsic ATPase and helicase activities. The cancer genomic sequencing data has identified frequently mutated residues in the CH-domain and ATP-binding site of UPF1. In silico screening of UPF1 stability change as a function over 41 cancer mutations has identified five variants with significant effects: K164R, R253W, T499M, E637K, and E833K. To explore the effects of these mutations on the associated energy landscape of UPF1, molecular dynamics simulations (MDS) were performed. MDS identified stable H-bonds between residues S152, S203, S205, Q230/R703, and UPF2/AMPPNP, and suggest that phosphorylation of Serine residues may control UPF1-UPF2 binding. Moreover, the alleles K164R and R253W in the CH-domain improved UPF1-UPF2 binding. In addition, E637K and E833K alleles exhibited improved UPF1-AMPPNP binding compared to the T499M variant; the lower binding is predicted from hindrance caused by the side-chain of T499M to the docking of the tri-phosphate moiety (AMPPNP) into the substrate site. The dynamics of wild-type/mutant systems highlights the flexible nature of the ATP-binding region in UPF1. These insights can facilitate the development of drug discovery strategies for manipulating NMD signaling in cell systems using chemical tools.
ChemInform Abstract: Highly Efficient Microwave‐Assisted CO Aminocarbonylation with a Recyclable Pd(II)/TPP‐β‐Cyclodextrin Cross‐Linked Catalyst. (2015)

Abstract A new recyclable catalytic system based on Pd(II) embedded in cross‐linked cyclodextrin is found to be very efficient in aminocarbonylation reactions of aryl iodides (I).
Fibre Bragg grating based effective soil pressure sensor for geotechnical applications (2009)

An effective-soil-pressure sensor for geotechnical applications based on Fibre Bragg Gratings is presented. The sensor simultaneous measures total soil pressure and pore pressure, allowing the calculation of the effective stress of soil. Calibration of the sensor using pressurised air demonstrated a pressure sensitivity of 2.02x10<sup>-3</sup> ± 2.84x10<sup>-5</sup>nm/kPa and 1.87x10<sup>-3</sup> ± 6.88x10<sup>-5</sup>nm/kPa for the total and pore pressure respectively. This corresponds to a pressure resolution of 4.95x10<sup>-1</sup>kPa and 5.46x10<sup>-1</sup>kPa for total and pore pressure using a 1pm interrogation system. Measurements undertaken in two types of soil demonstrated dependence of the total pressure sensitivity on soil density/stiffness. Pore pressure measurements agreed well with the preliminary calibration.
Bandwidth-Efficient Mobile Fronthaul Transmission for Future 5G Wireless Networks (2015)

We review recent advances in bandwidth-efficient mobile fronthaul transmission where multiple wireless signals are aggregated and transmitted with their spectral bandwidths unchanged. Applying this technique to future 5G wireless networks with massive-MIMO is also discussed.
Lightweight Communications and Marshalling for Low-Latency Interprocess Communication (2009)

We describe the Lightweight Communications and Marshalling (LCM) library for message passing and data marshalling. The primary goal of LCM is to simplify the development of low-latency message passing systems, targeted at real-time robotics applications. LCM is comprised of several components: a data type specification language, a message passing system, logging/playback tools, and real-time analysis tools. LCM provides a platform- and language-independent type specification language. These specifications can be compiled into platform and language specific implementations, eliminating the need for users to implement marshalling code while guaranteeing run-time type safety. Messages can be transmitted between different processes using LCM's message-passing system, which implements a publish/subscribe model. LCM's implementation is notable in providing low-latency messaging and eliminating the need for a central communications "hub". This architecture makes it easy to mix simulated, recorded, and live data sources. A number of logging, playback, and traffic inspection tools simplify common development and debugging tasks. LCM is targeted at robotics and other real-time systems where low latency is critical; its messaging model permits dropping messages in order to minimize the latency of new messages. In this paper, we explain LCM's design, evaluate its performance, and describe its application to a number of autonomous land, underwater, and aerial robots.
Jointly Learnable Behavior and Trajectory Planning for Self-Driving Vehicles (2019)

The motion planners used in self-driving vehicles need to generate trajectories that are safe, comfortable, and obey the traffic rules. This is usually achieved by two modules: behavior planner, which handles high-level decisions and produces a coarse trajectory, and trajectory planner that generates a smooth, feasible trajectory for the duration of the planning horizon. These planners, however, are typically developed separately, and changes in the behavior planner might affect the trajectory planner in unexpected ways. Furthermore, the final trajectory outputted by the trajectory planner might differ significantly from the one generated by the behavior planner, as they do not share the same objective. In this paper, we propose a jointly learnable behavior and trajectory planner. Unlike most existing learnable motion planners that address either only behavior planning, or use an uninterpretable neural network to represent the entire logic from sensors to driving commands, our approach features an interpretable cost function on top of perception, prediction and vehicle dynamics, and a joint learning algorithm that learns a shared cost function employed by our behavior and trajectory components. Experiments on real-world self-driving data demonstrate that jointly learned planner performs significantly better in terms of both similarity to human driving and other safety metrics, compared to baselines that do not adopt joint behavior and trajectory learning.
Effect of Ultra-Stokesian Drag and Particle Interception on Impaction Characteristics (1985)

The characteristics of impactors with round or rectangular nozzles have been determined by the numerical solution of the Navier-Stokes equations and of the equation of motion of the particles. The sensitivity of this solution to the system of grid lines was investigated by decreasing the spacing between them; these studies yielded sharper curves and higher √St50 for finer grids. The particle trajectory calculation program included an empirical ultra-Stokesian drag coefficient and a facility for handling particle interception. Studies comparing the results of runs made using the ultra-Stokesian drag law with those assuming Stokes law indicated that the latter underpredicts the √St20 by 5 to 10%. The influence of particle interception was found to be small except at very low Reynolds numbers, the characteristics for which demon strated low-efficiency tails. Dimensional analysis of the impactor system required the introduction of a second dimensionless quantity (in addition to the St) to char acterize the particle-fluid interaction for a given flow field. This dimensionless number, taken as (1/C)(ρ/ρ p ), was found to influence results at the high and low extremes of the Reynolds number only. For moderate values of the Reynolds number, a single curve relating collection efficiency to √St was found to characterize impactor systems adequately.
A Buckybowl with a Lot of Potential: <i>C</i><sub>5</sub>‐C<sub>20</sub>H<sub>5</sub>(CF<sub>3</sub>)<sub>5</sub> (2012)

Jede Menge Potential: Ein trifluormethyliertes Corannulen, C5-C20H5(CF3)5, wurde synthetisiert und spektroskopisch sowie röntgenographisch charakterisiert. In der Struktur findet sich eine hochgeordnete Stapelung der Schalen, die für Corannulene mit acyclischen Substituenten untypisch ist. Die erste Reduktion von C5-C20H5(CF3)5 ist 0.95 V anodisch verschoben; damit handelt es sich um den bislang stärksten Corannulen-basierten Elektronenakzeptor. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The International Cancer Expert Corps: A Unique Approach for Sustainable Cancer Care in Low and Lower-Middle Income Countries (2014)

The growing burden of non-communicable diseases including cancer in low- and lower-middle income countries (LMICs) and in geographic-access limited settings within resource-rich countries requires effective and sustainable solutions. The International Cancer Expert Corps (ICEC) is pioneering a novel global mentorship-partnership model to address workforce capability and capacity within cancer disparities regions built on the requirement for local investment in personnel and infrastructure. Radiation oncology will be a key component given its efficacy for cure even for the advanced stages of disease often encountered and for palliation. The goal for an ICEC Center within these health disparities settings is to develop and retain a high-quality sustainable workforce who can provide the best possible cancer care, conduct research, and become a regional center of excellence. The ICEC Center can also serve as a focal point for economic, social, and healthcare system improvement. ICEC is establishing teams of Experts with expertise to mentor in the broad range of subjects required to establish and sustain cancer care programs. The Hubs are cancer centers or other groups and professional societies in resource-rich settings that will comprise the global infrastructure coordinated by ICEC Central. A transformational tenet of ICEC is that altruistic, human-service activity should be an integral part of a healthcare career. To achieve a critical mass of mentors ICEC is working with three groups: academia, private practice, and senior mentors/retirees. While in-kind support will be important, ICEC seeks support for the career time dedicated to this activity through grants, government support, industry, and philanthropy. Providing care for people with cancer in LMICs has been a recalcitrant problem. The alarming increase in the global burden of cancer in LMICs underscores the urgency and makes this an opportune time fornovel and sustainable solutions to transform cancer care globally.
Near-Infrared Light Triggered ROS-activated Theranostic Platform based on Ce6-CPT-UCNPs for Simultaneous Fluorescence Imaging and Chemo-Photodynamic Combined Therapy (2016)

Many drug controlled release methods have been integrated in multifunctional nanoparticles, such as pH-, redox-, temperature-, enzyme-, and light-responsive release. However, few report is associated with the ROS responsive drug controlled release. Herein, a thioketal linker-based ROS responsive drug (camptothecin conjugated with thioketal linker, abbreviated as TL-CPT) was prepared and the thioketal linker could be cleaved by ROS(reactive oxygen species). To achieve cancer simultaneous optical imaging, photodynamic therapy and chemotherapy, the photosensitizer Chlorin e6(Ce6), TL-CPT and carboxyl-mPEG were loaded on the upconversion nanoparticles (UCNPs), which were named as Ce6-CPT-UCNPs. Under 980 nm laser irradiation, Ce6-CPT-UCNPs emitted a narrow emission band at 645-675 nm which was overlapped with Ce6 absorption peak. Ce6 absorbed the light to produce ROS, which was used for photodynamic therapy and to cleave the thioketal linker in Ce6-CPT-UCNPs to release camptothecin for chemotherapy. Meanwhile, Ce6 absorbed the light, was used for near-infrared fluorescence imaging. The in vivo biodistribution studies showed that the prepared nanoparticles had high orthotopic lung cancer targeting efficiency. The in vivo therapeutic results demonstrated that NCI-H460 lung cancers could be completely eliminated by combining chemo- and photodynamic therapy under 980 nm laser irradiation. The prepared multifunctional Ce6-CPT-UCNPs have great potential in applications such as cancer targeted fluorescent imaging, simultaneous ROS activated chemo- and photodynamic therapy in near future.
A Review of Field-Based Assessments of Neuromuscular Control and Their Utility in Male Youth Soccer Players (2017)

Read, PJ, Oliver, JL, Croix, MS, Myer, GD, and Lloyd, RS. A review of field-based assessments of neuromuscular control and their utility in male youth soccer players. J Strength Cond Res 33(1): 283-299, 2019-Lower-extremity injuries in male youth soccer are common and equate to a substantial time loss from training and competitions during the course of a season. Extended periods of absence will impact player involvement in skill and physical development activities, as well as participation in competitive match play. Neuromuscular risk factors for lower-extremity injury in male youth soccer players can be categorized into quadriceps dominance, leg dominance, ligament dominance, trunk dominance, and reduced dynamic stability. Valid screening methods to identify risk factors that are practically viable are needed for youth athletes who may be at a greater risk of injury in soccer. Although field-based tests of neuromuscular control provide a reliable option for the assessment of injury risk in adults and females, less data are available in male youth soccer players, and further research is required to examine their ability to predict injury risk. This article provides a review of the current literature pertaining to field-based screening tests and critically appraises their suitability for use with male youth soccer players. Currently, the only method that has been validated in male youth soccer players is the landing error scoring system. Asymmetrical anterior reach measured during the Y-Balance test may also be considered because of its strong predictive ability in male youth basketball players; however, further research is required to fully support its use with soccer players.
ChemInform Abstract: CATALYTIC SYNTHESIS OF FLUOROAROMATIC URETHANES IN THE PRESENCE OF SELENIUM‐CONTAINING COMPOUNDS (1984)

Abstract In Gegenwart der Harnstoff‐analogen Selenverbindung (II) reagieren die Nitroaromaten (I) mit CO/Et‐OH zu den Urethanen (III) bzw. (VI).
Chemical Composition and in Vitro Antioxidant Evaluation of Commercial Water-Soluble Willow Herb (<i>Epilobium angustifolium</i> L.) Extracts (2006)

Five commercially available water-soluble extracts prepared from the aerial parts of Epilobium angustifolium L. (Onagraceae) were screened for antioxidant-related properties in a battery of six in vitro assays. Total phenol content and qualitative-quantitative analyses were also carried out. The extracts demonstrated varying degrees of efficacy in each screen. Two extracts, denoted as nonfermented and Tver, were the most effective toward reducing iron(III), scavenging 1,1-diphenyl-2-picrylhydrazyl free radicals, inhibiting hydroxyl radical-catalyzed bovine brain-derived phospholipid degradation, and non-site- and site-specific hydroxyl radical-catalyzed 2-deoxy-D-ribose degradation. The activity profile of the extracts changed, however, when their iron(II) chelating ability was assessed. The nonfermented and Tver extracts were not as effective iron(II) chelators as the extract denoted as Lotos. All the extracts contained Folin-Ciocalteu-reactive substances, which was confirmed by the presence of predominantly polar phenolic analytes (i.e., hydroxylated benzoic acid derivatives and flavonoids).