gebhart/patrepeval huggingface dataset:
Numerical modeling of device structure for FeS&lt;inf&gt;2&lt;/inf&gt; thin film solar cells (2016)

This paper describes device modeling of FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> thin-film solar cells by device simulation to investigate the cause of 0% conversion efficiency from the reported device structure. We demonstrated that the reported device didn't form a suitable structure as a photovoltaic device. In order to achieve FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> photovoltaic device, we suggested that obtaining not only suitable band structure but also suitable band gap of FeS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> was necessary.
RETRACTED: Splicing-defective mutants of the yeast mitochondrial COXI gene can be corrected by transformation with a hybrid maturase gene. (1991)

We have developed a recombinant vector, termed pMIT, for transient expression of genes delivered to yeast mitochondria by biolistic transformation. Using that vector, we introduced a hybrid RNA maturase (splicing) gene into mitochondria of rho 0 petite cells and showed the gene to be functional in crosses. The hybrid maturase is an in-frame fusion between the N-terminal half of the maturase encoded by intron 1 of the COXI (cytochrome oxidase) gene and the C-terminal half of a similar maturase encoded by COXI intron 2. pMIT transformants can provide a functional maturase in crosses to restore respiration and COXI polypeptide synthesis to a respiratory-deficient strain defective in the synthesis of a maturase encoded by COXI intron 1; the transformant will also restore respiration to two splicing-defective cis mutants of COXI introns 1 and 3. We detect a 68-kDa polypeptide comparable in abundance to other major mitochondrial translation products as a likely product of the hybrid maturase gene. Transformants containing an internal 218-amino acid deletion mutation of the hybrid maturase gene no longer express a functional maturase in crosses and produce the expected shortened polypeptide of approximately 40 kDa; however, those transformants still restore respiration to the COXI cis mutants. These studies show the utility of the pMIT transformation system for the expression and reverse genetic analysis of yeast mitochondrial genes.
Fatal Disseminated Adenovirus Disease in a Patient who Received Chemotherapy for Mantle Cell Lymphoma: A Case Report (2023)

Disseminated adenovirus infections in patients who received chemotherapy alone for lymphoma are extremely rare, however, should be included in differential diagnosis for those who received T cell suppressive agents. We report a fatal case of disseminated adenovirus disease in a patient who had received chemotherapy and presented with hypoxia
A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation (2023)

Inhibition of amyloid-β peptide (Aβ) accumulation in the brain is a promising approach for treatment of Alzheimer's disease (AD). Aβ is produced by β-secretase and γ-secretase in endosomes via sequential proteolysis of amyloid precursor protein (APP). Aβ and APP have a common feature to readily cluster to form multimers. Here, using multivalent peptide library screens, we identified a tetravalent peptide, LME-tet, which binds APP and Aβ via multivalent interactions. In cells, LME-tet-bound APP in the plasma membrane is transported to endosomes, blocking Aβ production through specific inhibition of β-cleavage, but not γ-cleavage. LME-tet further suppresses Aβ aggregation by blocking formation of the β-sheet conformation. Inhibitory effects are not observed with a monomeric peptide, emphasizing the significance of multivalent interactions for mediating these activities. Critically, LME-tet efficiently reduces Aβ levels in the brain of AD model mice, suggesting it may hold promise for treatment of AD.
Virtual Issue on Carbon Dioxide: Physical Chemistry That Impacts Its Capture, Sequestration, and Conversion (2022)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTVirtual Issue on Carbon Dioxide: Physical Chemistry That Impacts Its Capture, Sequestration, and ConversionEdward J. Maginn*Edward J. MaginnDepartment of Chemical and Biomolecular Engineering, University of Notre Dame, Notre Dame, Indiana 46556 United States*E-mail: [email protected]. Phone: +1 574 631 5687.More by Edward J. Maginnhttps://orcid.org/0000-0002-6309-1347Cite this: J. Phys. Chem. B 2022, 126, 48, 9927–9929Publication Date (Web):December 8, 2022Publication History Received27 October 2022Published online8 December 2022Published inissue 8 December 2022https://pubs.acs.org/doi/10.1021/acs.jpcb.2c07562https://doi.org/10.1021/acs.jpcb.2c07562editorialACS PublicationsCopyright © Published 2022 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1062Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (978 KB) Get e-AlertscloseSUBJECTS:Diffusion,Liquids,Molecular dynamics,Salts,Solvents Get e-Alerts
Simultaneous measurement of soft error rate of 90 nm CMOS SRAM and cosmic ray neutron spectra at the summit of Mauna Kea (2008)

We carried out simultaneous measurement of SERs and cosmic ray neutron spectra for the first time. We measured SERs using 90 nm CMOS SRAM chips and measured neutron spectra using a Bonner multisphere spectrometer. We carried out the SER field measurement at the 4200 m summit of Mauna Kea, which is the most suitable place for SER field measurements because the neutron flux is over 10 times greater there than that at sea level. Therefore, we could avoid making field measurements that usually require a long measuring time (about a year) to obtain sufficient accuracy.
Effect of surface resistor loading on high‐impedance surface radar absorber return loss and bandwidth (2009)

Abstract A simple method for the selection of the appropriate choice of surface‐mounted loading resistor required for a thin radar absorber based on a high‐impedance surface (HIS) principle is demonstrated. The absorber consists of a HIS, (artificial magnetic ground plane), thickness 0.03 λ 0 surface‐loaded resistive‐elements interconnecting a textured surface of square patches. The properties of absorber are characterized under normal incident using a parallel plate waveguide measurement technique over the operating frequency range of 2.6–3.95 GHz. We show that for this arrangement return loss and bandwidth are insensitive to ±2% tolerance variations in surface resistor values about the value predicted using the method elaborated in this letter, and that better than −28 dB at 3.125 GHz reflection loss can be obtained with an effective working bandwidth of up to 11% at −10 dB reflection loss. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 1773–1775, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24454
Method for the separation of overlapping density porous materials from less porous materials (2023)

Enhanced methods for separating of overlapping density porous materials are provided. The methods of the invention exploit the differences in the porosity of porous feed materials compared to that of the solid plastics. In the first stage, air is forced out of the pores of a porous feed material. In the second stage, a solution, having the appropriate density, is forced into the pores. This increases the density of the porous material relative to the density of the solid plastics. As a result, the porous material can be made to sink, while the solid plastics continue to float.
&lt;title&gt;Optimization of two-dimensional photonic bandgap structures&lt;/title&gt; (2001)

Photonic band gap structures and their applications have gained a great deal of interest in recent years, with the primary focus on designing structures that have specific optical characteristics. However, little attention has been given to solving the inverse problem of determining the optimum photonic lattice given a desired output. In this paper, we address this need using optimization techniques to design two-dimensional photonic crystals to arbitrarily guide light in two dimensions. By switching the rods of this lattice on and off (rod or no rod), the optimization algorithm arrives at a solution (distribution of the rod in this lattice) that minimizes the cost function. The performance of the optimization is driven by the proper selection of both the cost function and optimization algorithm.
Predicting the Time to Detect Moderately Virulent African Swine Fever Virus in Finisher Swine Herds Using a Stochastic Disease Transmission Model (2021)

Abstract Background: African swine fever (ASF) is a highly contagious and devastating pig disease that has caused extensive global economic losses. Understanding ASF virus (ASFV) transmission dynamics within a herd is necessary in order to prepare for and respond to an outbreak in the United States. Although the transmission parameters for the highly virulent ASF strains have been estimated in several articles, there are relatively few studies focused on moderately virulent strains. Using an approximate Bayesian computation algorithm in conjunction with Monte Carlo simulation, we have estimated the adequate contact rate for moderately virulent ASFV strains and determined the statistical distributions for the durations of mild and severe clinical signs using individual, pig-level data. A discrete individual based disease transmission model was then used to estimate the time to detect ASF infection based on increased mild clinical signs, severe clinical signs, or daily mortality. Results: Our results indicate that it may take two weeks or longer to detect ASF in a finisher swine herd via mild clinical signs or increased mortality beyond levels expected in routine production. A key factor contributing to the extended time to detect ASF in a herd is the fairly long latently infected period for an individual pig (mean 4.5, 95% P.I., 2.4 - 7.2 days). Conclusion: These transmission model parameter estimates and estimated time to detection via clinical signs provide valuable information that can be used not only to support emergency preparedness but also to inform other simulation models of evaluating regional disease spread.
Causes, consequences, and amelioration of late adverse ventricular remodeling after myocardial infarction (2012)

Department of Medicine, Cardiovascular Research Institute, University of Vermont, Colchester, Vermont, USA The Editor’s Corner appears periodically in Coronary Artery Disease. The Editor and Associate Editors consider ethical, social, and philosophical issues affecting cardiology and medicine. From time to time, we publish observations and conjectures by the editor and his colleagues such as the following article addressing negative left ventricular remodeling. Correspondence to A.K.M. Tarikuz Zaman, PhD, University of Vermont, 208 South Park Drive, Room 240, Colchester, VT 05446, USA Tel: +1 802 656 3362; fax:+1 802 656 8957; e-mail: [email protected] Received January 6, 2012 Accepted January 12, 2012
Bolus arrival time estimation in dynamic contrast-enhanced magnetic resonance imaging of small animals based on spline models (2019)

Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used to quantify perfusion and vascular permeability. In most cases a bolus arrival time (BAT) delay exists between the arterial input function (AIF) and the contrast agent arrival in the tissue of interest which needs to be estimated. Existing methods for BAT estimation are tailored to tissue concentration curves, which have a fast upslope to the peak as frequently observed in patient data. However, they may give poor results for curves that do not have this characteristic shape such as tissue concentration curves of small animals. In this paper, we propose a method for BAT estimation of signals that do not have a fast upslope to their peak. The model is based on splines which are able to adapt to a large variety of concentration curves. Furthermore, the method estimates BATs on a continuous time scale. All relevant model parameters are automatically determined by generalized cross validation. We use simulated concentration curves of small animal and patient settings to assess the accuracy and robustness of our approach. The proposed method outperforms a state-of-the-art method for small animal data and it gives competitive results for patient data. Finally, it is tested on in vivo acquired rat data where accuracy of BAT estimation was also improved upon the state-of-the-art method. The results indicate that the proposed method is suitable for accurate BAT estimation of DCE-MRI data, especially for small animals.
Nanodomain engineering in two-dimensional /spl Lambda//sup (2)/ nonlinear photonic crystal on bulk lithium niobate (2005)

Four-to-six fold rotation-symmetry with sub-mum domain size is observed in periodically-poled LiNbO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> . Depth-resolved pyroelectric microscopy analysis indicates the 2D-confinement of inverted domains is ascribed to selective nucleation and minimized fringe-field effect by flattened polystyrene spheres on the surface
Device pairing based on adaptive channel fluctuation control for large-scale organizations (2009)

We are developing device pairing methods that enable a user to establish two devices, such as a mobile phone and a PC as a device pair. In our previous developed method, a user can create a device pair by simultaneously clicking the pairing buttons shown on their screens. However, when the system handles many users, clicks from different users could overlap, resulting in request collisions. In this paper, we propose a device pairing method that can keep the collision probability under a permissible limit by using multiple pairing buttons. In this method, a single pairing button with a numeric identifier is shown on a mobile phone, and multiple buttons with different numeric identifiers are shown on a PC. First, a user chooses the button on the PC with the same identifier as the one on the phone. Then, the user simultaneously clicks the single button on the phone and the corresponding button on the PC. A device pair is created based on not only the simultaneity of the two clicks but also the correspondence between the two buttons' identifiers. If too many pairing buttons are shown on a PC, it will be bothersome for the user to choose one button from many candidates: the smaller the number of pairing buttons shown on a PC, the simpler the user operation. To ensure ease of user operation, our method adaptively fluctuates the number of pairing buttons shown on a PC, i.e., the number of device pairing channels, according to the latest amount of pairing requests from users.
Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles (2020)

Extracellular vesicles (EVs) mediate critical intercellular communication within healthy tissues, but are also exploited by tumour cells to promote angiogenesis, metastasis, and host immunosuppression under hypoxic stress. We hypothesize that hypoxic tumours synthesize hypoxia-sensitive proteins for packing into EVs to modulate their microenvironment for cancer progression. In the current report, we employed a heavy isotope pulse/trace quantitative proteomic approach to study hypoxia sensitive proteins in tumour-derived EVs protein. The results revealed that hypoxia stimulated cells to synthesize EVs proteins involved in enhancing tumour cell proliferation (NRSN2, WISP2, SPRX1, LCK), metastasis (GOLM1, STC1, MGAT5B), stemness (STC1, TMEM59), angiogenesis (ANGPTL4), and suppressing host immunity (CD70). In addition, functional clustering analyses revealed that tumour hypoxia was strongly associated with rapid synthesis and EV loading of lysosome-related hydrolases and membrane-trafficking proteins to enhance EVs secretion. Moreover, lung cancer-derived EVs were also enriched in signalling molecules capable of inducing epithelial-mesenchymal transition in recipient cancer cells to promote their migration and invasion. Together, these data indicate that lung-cancer-derived EVs can act as paracrine/autocrine mediators of tumorigenesis and metastasis in hypoxic microenvironments. Tumour EVs may, therefore, offer novel opportunities for useful biomarkers discovery and therapeutic targeting of different cancer types and at different stages according to microenvironmental conditions.
Advanced Diesel Particulate Filter Design for Lifetime Pressure Drop Solution in Light Duty Applications (2007)

&lt;div class="htmlview paragraph"&gt;Highly efficient wall-flow diesel particulate filters (DPF) are the primary means of PM emissions control in light-duty diesel vehicles. The successful commercialization of DPF technology has allowed combining attractive characteristics (good fuel economy, high low-end torque characteristics) of a diesel engine with significant PM emissions reductions to meet the stringent legislation.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;The design for advanced filter systems is driven by the lifetime pressure drop requirements with the accumulation of non-combustible materials (ashes) over time in the filter. More compact filter designs can be achieved by using filters with the proprietary Asymmetric Cell Technology (ACT) providing a larger inlet channel volume and therefore a higher ash storage capacity in the same space envelope without compromising the filter bulk heat capacity and mechanical integrity. The current work on engine dynamometer demonstrates a 65% higher ash capacity to reach the same pressure drop threshold compared to the same volume filter with the standard cell design. This benefit can be utilized in different ways dependent on the application requirements, like lower lifetime pressure drop or longer service interval for the same size filter or a smaller filter volume with the same service interval. In combination with the robust DuraTrap® AT filter material, the ACT design has the potential to meet the soot load as well as lifetime pressure drop requirements in a very compact package of 75% of the standard filter at equal total soot load levels.&lt;/div&gt;
Sorting Laguerre-Gaussian modes by radial quantum number (2018)

An efficient sorter based on the fractional Fourier transform is realized to detect the radial quantum number of the Laguerre-Gaussian modes. The reported scheme can, in principle, have unit efficiency and no cross-talk.
Behavioural effects of acute phenylalanine and tyrosine depletion in healthy male volunteers (2002)

Acute phenylalanine and tyrosine depletion (APTD) studies have been used to assess the role of the cathecholaminergic system in various aspects of human behaviour. In this study we conducted a randomized, double-blind, controlled and cross-over comparison to evaluate the effects of APTD on memory, attention and mood in normal subjects. Twelve healthy male volunteers were included in this study. The subjects ingested a nutritionally balanced mixture (B) or a similar mixture deficient in phenylalanine and tyrosine (PT-). Before and 5 h after ingestion of the drink, volunteers underwent tests on mood, memory and attention. Results of the memory tests showed that PT- mixture impaired word recall as measured in Rey's test (p = 0.016). The assessment of changes in mood showed that the balanced mixture improved scores of as alertness (VAMS factor I, p = 0.037) and the PT- mixture induces an opposite effect, increased scores of anxiety (Profiles of Mental State composed-anxious dimension, p = 0.022). These results suggest that tyrosine plasma levels and cathecholamines may be important factors in regulating mood and memory.
Autologous stem cell therapy in the treatment of limb ischaemia induced chronic tissue ulcers of diabetic foot patients (2012)

The transplantation of BMCs as well as TRCs proved to be safe and feasible. Improvements of microcirculation and complete wound healing were observed in the transplant groups.
Expression of Glutamine Synthetase and Carbamoylphosphate Synthetase I in a Bioartificial Liver: Markers for the Development of Zonation in vitro (2008)

Induction of GS expression inside the AMC-BAL is not dependent of (low) oxygen tensions and hepatic nuclear factor 4alpha transcript levels. GS expression might be related to (1) low substrate levels and/or autocrine soluble factors, or (2) to cytoskeleton interactions, putatively associated with the beta-catenin signaling pathway.
Studies on the Synthesis of Apoptolidin: Progress on the Stereocontrolled Assembly of the Pseudo Aglycone of Apoptolidin (2005)

Abstract Progress on a stereocontrolled total synthesis of the pseudo aglycone of apoptolidin ( 2 ) starting from ( S )‐epichlorohydrin is reported. The lower C(12)–C(28) fragment ( 4 ) was derived by consecutive stereoselective aldol reactions and extended using a Suzuki cross‐coupling reaction. Studies on glycoyslation of the C9 hydroxy group are also described. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2006)
Nonmutagenic mechanisms in carcinogenesis: role of protein kinase C in signal transduction and growth control. (1991)

There is accumulating evidence that the multistage carcinogenic process is associated with the progressive acquisition of mutations in cellular proto-oncogenes and in growth-suppressor genes. At the same time, several types of evidence indicate that nongenotoxic agents and epigenetic events also play an important role in the evolution of tumors. One of the most intensively studied nongenotoxic agents is the phorbol ester tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) and related compounds. Since TPA appears to exert its biologic effects through protein kinase C (PKC), a key enzyme in signal transduction, we have studied this enzyme in considerable detail. Our strategy has been to perturb signal transduction by developing cell lines that overexpress the beta 1 isoform of PKC. Such derivatives of rat fibroblasts display alterations in morphology and growth factors, altered expression of c-myc, ornithine decarboxylase, and phorbin, and increased susceptibility to transformation by certain oncogenes, H-ras, myc, and fos. These findings provide direct genetic evidence that PKC plays a critical role in growth control and the action of certain growth factors, tumor promoters, and oncogenes. In related studies, we have characterized the beta 1 isoform that is overproduced in the above cell systems in terms of its biochemical, kinetic, and immunologic properties. The enzyme has several properties characteristic of native PKCs. A surprising finding is that c-H-ras-transformed derivatives of the cells that overexpress PKC beta 1 display a several-fold increase in the expression of the endogenous alpha 1 isoform of PKC and a decrease in the expression of the endogenous epsilon isoform.(ABSTRACT TRUNCATED AT 250 WORDS)