gebhart/patrepeval huggingface dataset:
Simulation of V-shaped stability in AFLC (2002)

The V-shaped transmission-voltage characteristics in FLC have been explained by the existence of a splayed state, caused by strong polar interaction with the alignment layers. Both simulation results and analytical calculations have been used to confirm this statement. The conditions that guarantee V-shaped characteristics have been described. There is no consensus on whether V-shaped characteristics can exist in AFLC. In tri-state switching the AFLC will be in the so-called ferroelectric up- (or down-) state FU (FD) for sufficiently high applied positive (negative) voltage. By means of the uniform-(phi) theory it has been shown that if V decreases to zero, one first follows the symmetrical up- (down-) state SU (SD), and then switches back to the normal alternating state so called antiferroelectric state AF. In this article we investigate switching from a strong positive voltage to zero and check under which conditions one ends up in a special alternating state SA, with both polarizations parallel to the glass surfaces, instead of in the normal alternating state, with both polarizations perpendicular to the glass surfaces. The first case guarantees V-shaped switching in AFLC, the second case leads to tri-stable switching. The simulation program is based on implicit iteration and on the Newton-Raphson linearization method. Several simulation results will be shown and discussed. They confirm that V-shaped switching occurs in AFLC under approximately the same conditions as for FLC, i.e. with strong interactions with the alignment layers.
Iron‐depleted Bi‐YIG having enhanced gyromagnetic properties suitable for LTCC processing (2018)

Abstract The traditional method of ferrite synthesis is based upon solid‐state reaction. The advantages of this approach include simplicity, cost effectiveness, and suitability for commercial process scaling. However, there exist shortcomings in that impurities and defects adversely affect magnetic properties. Here, iron‐depleted compositions of bismuth‐substituted yttrium iron garnet (ie Bi:YIG) were studied with emphasis placed on the impact of synthesis processing parameters upon the structure and gyromagnetic properties. It was shown that ferrimagnetic resonance linewidth experienced a minimum of 180.3 Oe (X‐band) when the sample stoichiometry was 4% depleted in iron (x = 0.2), a reduction of 29.3% from the parent compound. Concomitantly, iron depletion caused a systematic change in lattice parameter that resulted in a dilation of Goodenough‐Kanamori‐Anderson bond angles increasing exchange energy and magnetization. The substitution of Bi for Y on the dodecahedron sites altered the reaction path and decreased the activation energy effectively reducing sintering temperature. To establish a functional processing protocol, an ion diffusion model is presented to explain the demonstrated processing, structure, and performance paradigm.
Galet-LSC, A Geant4 Application Templet and its Application for Liquid Scintillation Counter (2018)

Geant4 is a Monte Carlo simulation toolkit to simulate interactions of particles with matter. It is widely used in various science field such as high energy physics, nuclear physics, space and medicine. Since Geant4 only provides users with a series of class libraries, users need to develop their own code for target application. It requires user's expertise in application software developments and deep knowledge of Geant4 classes. In order to minimize such efforts in Geant4 application developments, we have proposed a Geant4 application templet (Galet), that is a skeleton Geant4 application program for primer As one of integrated software based on the Galet, a simulation for liquid scintillation counter system (Galet-LSC) has been developed. It modeled two LSC systems, LSC-5100 and LSC-LB7 manufactured by Hitachi, Ltd. The simulator aims to study characteristics of counting efficiency in various system configurations as well as liquid scintillation properties. In this paper, firstly, the concept and design of Galet are briefly described. Secondly the functions of Galet-LSC is presented. Thirdly, some preliminary results in Galet-LSC are demonstrated.
A novel ACE2 activator reduces monocrotaline-induced pulmonary hypertension by suppressing the JAK/STAT and TGF-β cascades with restored caveolin-1 expression (2014)

NCP-2454 prevented MCT-induced PH by suppressing intracellular inflammatory cascades, an upstream molecular change of which is the disruption of Cav-1 expression.
Genotyping Microarray for CSNB-Associated Genes (2009)

This relatively inexpensive first-pass genetic testing device for patients with a diagnosis of CSNB will improve molecular diagnostics and genetic counseling of patients and their families and gives the opportunity to analyze whether, for example, more progressive disorders such as cone or cone-rod dystrophies underlie the same gene defects.
Boundary-Layer Stability Analysis of the Mean Flows Obtained Using Unstructured Grids (2014)

Boundary-layer stability analyses of mean flows extracted from unstructured-grid Navier–Stokes solutions have been performed. A procedure has been developed to extract mean flow profiles from the FUN3D unstructured-grid solutions for the purpose of stability analysis. Extensive code-to-code validations were performed by comparing the extracted mean flows as well as the corresponding stability characteristics to the predictions based on structured-grid mean flow solutions. Comparisons were made for a set of progressively complex geometric configurations ranging from a simple flat plate to a full aircraft configuration: a modified Gulfstream III with a natural laminar-flow glove. The results for the swept wing flow over the wing–glove assembly point to the need for stability analysis based on Navier–Stokes solutions or possibly fully three-dimensional boundary-layer codes when the underlying flow develops strong three-dimensionality. The effect of grid resolution, mean flow convergence, and low-order interpolation to a stability grid on metrics relevant to linear stability of the boundary-layer flow are also examined to provide guidelines for the use of both structured and unstructured grids in practical applications related to transition prediction for swept wing boundary layers.
Objective way to support embryo transfer: a probabilistic decision (2013)

This study was supported by a grant, CTI Medtech Project Number: 9707.1 PFLS-L, Swiss Confederation. No competing interests are declared.
Scl regulates the quiescence and the long-term competence of hematopoietic stem cells (2009)

The majority of long-term reconstituting hematopoietic stem cells (LT-HSCs) in the adult is in G(0), whereas a large proportion of progenitors are more cycling. We show here that the SCL/TAL1 transcription factor is highly expressed in LT-HSCs compared with short-term reconstituting HSCs and progenitors and that SCL negatively regulates the G(0)-G(1) transit of LT-HSCs. Furthermore, when SCL protein levels are decreased by gene targeting or by RNA interference, the reconstitution potential of HSCs is impaired in several transplantation assays. First, the mean stem cell activity of HSCs transplanted at approximately 1 competitive repopulating unit was 2-fold decreased when Scl gene dosage was decreased. Second, Scl(+/-) HSCs were at a marked competitive disadvantage with Scl(+/+) cells when transplanted at 4 competitive repopulating units equivalent. Third, reconstitution of the stem cell pool by adult HSCs expressing Scl-directed shRNAs was decreased compared with controls. At the molecular level, we found that SCL occupies the Cdkn1a and Id1 loci in primary hematopoietic cells and that the expression levels of these 2 regulators of HSC cell cycle and long-term functions are sensitive to Scl gene dosage. Together, our observations suggest that SCL impedes G(0)-G(1) transition in HSCs and regulates their long-term competence.
Abstract 15078: Long-Non-Coding RNA HypERrlnc Regulates Human Pericyte Function by Modulation of the Endoplasmic Reticulum-Stress Cell Response (2016)

Introduction: Pericytes are perivascular mural cells that induce vessel maturation and endothelial barrier function. Long non-coding RNAs (lncRNAs) are known to influence endothelial cell function, but their role in pericyte biology remains unexplored. Endoplasmic reticulum (ER) stress is a common cellular response upon stimuli such as hypoxia that triggers cell death and consecutive organ dysfunction. Here we show that lncRNA HypeERlnc (Hypoxia-Induced Endoplasmic Reticulum-Stress Regulating RNA) affects pericyte function by modulating the ER-stress cell response. Methods and Results: RNA seq identified 30 hypoxia regulated lncRNAs in primary human pericytes (hPC), including HypERrlnc. Silencing HypERrlnc, which is enriched in the nucleus (nucleus/cytosol ratio: 1.55±0.09, n=3), with LNA-GapmeRs decreased cell viability (MTT assay: 0.77±0.02 vs Ctrl, P Conclusion: LncRNA HypERrlnc regulates the evolution of ER-stress and is important for pericyte survival, proliferation, differentiation, coronary endothelial recruitment and endothelial barrier function. Moreover, downregulation of HypERrlnc in chronic heart failure indicates a role of HypERrlnc in human cardiac disease.
Saturation Phenomenon of Stress-Induced Gate Leakage Current (2002)

The saturation phenomenon of stress-induced leakage currents (SILCs) is monitored with various stress voltages, gate oxide thicknesses and temperatures for gate oxides formed with different fabrication processes. It is found that there exist seeds of defects at the point when the gate oxide is fabricated and the number of the seeds determines the saturation phenomenon. Injected holes do not create new sites of defects, but help to activate the seeds of defects. Degradation models are proposed based on the percolation theory. In the presaturation region, defects in the body of the oxide are activated and SILC increases rapidly. The saturation phenomenon occurs when most of the seeds are activated. After saturation, many holes are used to create interface states and the increase of the SILC is suppressed.
Telomerase Inhibition and Cell Growth Arrest After Telomestatin Treatment in Multiple Myeloma (2004)

These results demonstrate that telomestatin exerts its antiproliferative and proapoptotic effects in myeloma cells via inhibition of telomerase and subsequent reduction in telomere length. We conclude that telomerase is an important potential therapeutic target for multiple myeloma therapy, and G-quadruplex interacting agents with specificity for binding to telomeric sequences can be important agents for additional evaluation.
DNA : changing science and society (2004)

Introduction -- Torsten Krude -- Ch. 1. The discovery of the DNA double helix / Aaron Klug -- Ch. 2. Genetic fingerprinting / Alec J. Jeffreys -- Ch. 3. Ancient DNA / Svante Paabo -- Ch. 4. DNA and cancer / Ron Laskey -- Ch. 5. DNA, biotechnology and society / Malcolm Grant -- Ch. 6. DNA and reproductive medicine / Robert M.L. Winston -- Ch. 7. Genes and language / Dorothy V.M. Bishop -- Ch. 8. DNA and ethics / Onora O'Neill -- Notes on the contributors -- Index -- The plate section for chapter 1 is between pp. 26 and 27 -- The plate section for chapter 4 is between pp. 90 and 91 -- The plate section for chapter 6 is between pp. 122 and 123
Laser Plasma Accelerators (2011)

The concepts of laser‐plasma based accelerator and injector are discussed here. A two stage laser plasma accelerator design study for the production of a high‐quality GeV electron beam with low energy spread (1%) is proposed. New results demonstrating colliding laser pulse scheme will be also presented. These laser‐produced particle beams have a number of interesting properties and could lend themselves to applications in many fields, including medicine (radiotherapy), chemistry (radiolysis), accelerator physics. They could be used as a source for the production of γ ray beams for non‐destructive material inspection by radiography, or for future compact XFEL machines.
Complex study of solitonic ultrafast self-switching in slightly asymmetric dual-core fibers (2021)

We present a complex study of pulse-energy-controlled solitonic self-switching of femtosecond pulses at wavelengths of 1700 and 1560 nm in two nonlinear high-index contrast dual-core fibers having different levels of slight asymmetry. In the case of the fiber with higher dual-core asymmetry excited by 1700 nm pulses, the highest switching contrast of 20.8 dB at 40 mm fiber length was demonstrated. It was accompanied by multiple exchanges of the dominant core at the fiber output, which is a strong signature of the soliton-based switching process. In the case of the fiber with lower dual-core asymmetry, excited by 1560 nm pulses, the highest switching contrast of 21.4 dB at 35 mm fiber length was achieved with a broadband character of the switching in the spectral range of 1450-1650 nm. Both demonstrations represent progress in all-optical switching studies at these particular wavelengths thanks to a comparison between their results, which reveals the requirement of a higher level of dual-core symmetry for applicable C-band operation.
A calibration-and-error correction method for improved texel (fused ladar/digital camera) images (2012)

The fusion of imaging ladar information and digital imagery results in 2.5-D surfaces covered with texture information. Called "texel images," these datasets, when taken from dierent viewpoints, can be combined to create 3-D images of buildings, vehicles, or other objects. These 3-D images can then be further processed for automatic target recognition, or viewed in a 3-D viewer for tactical planning purposes. This paper presents a procedure for calibration, error correction, and fusing of ladar and digital camera information from a single hand-held sensor to create accurate texel images. A brief description of a prototype sensor is given, along with calibration technique used with the sensor, which is applicable to other imaging ladar/digital image sensor systems. The method combines systematic error correction of the ladar data, correction for lens distortion of the digital camera image, and fusion of the ladar to the camera data in a single process. The result is a texel image acquired directly from the sensor. Examples of the resulting images, with improvements from the proposed algorithm, are presented.
Diversity and population structure of a near–shore marine–sediment viral community (2004)

Viruses, most of which are phage, are extremely abundant in marine sediments, yet almost nothing is known about their identity or diversity. We present the metagenomic analysis of an uncultured near-shore marine-sediment viral community. Three-quarters of the sequences in the sample were not related to anything previously reported. Among the sequences that could be identified, the majority belonged to double-stranded DNA phage. Temperate phage were more common than lytic phage, suggesting that lysogeny may be an important lifestyle for sediment viruses. Comparisons between the sediment sample and previously sequenced seawater viral communities showed that certain phage phylogenetic groups were abundant in all marine viral communities, while other phage groups were under-represented or absent. This 'marineness' suggests that marine phage are derived from a common set of ancestors. Several independent mathematical models, based on the distribution of overlapping shotgun sequence fragments from the library, were used to show that the diversity of the viral community was extremely high, with at least 10(4) viral genotypes per kilogram of sediment and a Shannon index greater than 9 nats. Based on these observations we propose that marine-sediment viral communities are one of the largest unexplored reservoirs of sequence space on the planet.
Chemically tuning attractive and repulsive interactions between solubilizing oil droplets (2022)

Solubilization is a spontaneous transport process occurring in surfactant-stabilized emulsions that can lead to Marangoni flow and droplet motility. Conventionally, active droplets exhibit self-propulsion and pairwise repulsion due to solubilization processes and/or solubilization products raising the droplet’s interfacial tension. Here, we report emulsions with the opposite behavior, wherein solubilization and/or its products decrease the interfacial tension and cause droplets to attract. We systematically characterize the influence of oil structure, nonionic surfactant structure, and surfactant concentration on the interfacial tensions and Marangoni flows of solubilizing oil-in-water drops. Three regimes corresponding to droplet “attraction”, “repulsion” or “inactivity” are identified and the chemical trends leading to these behaviors are discussed. Notably, droplet inactivity, wherein no convective flow is observed, can still occur even when the droplet is solubilizing at appreciable rates. Droplets that are inactive can be induced to become active through doping of the surfactant continuous phase with another oil type. We believe these studies contribute to a new fundamental understanding of solubilization processes in emulsions and provide guidance as to how chemical parameters can be used to influence the dynamics and chemotactic interactions between active droplets.
Measurement of the high-mass Drell–Yan differential cross-section in pp collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:msqrt><mml:mi>s</mml:mi></mml:msqrt><mml:mo>=</mml:mo><mml:mn>7</mml:mn><mml:mtext> </mml:mtext><mml:mtext>TeV</mml:mtext></mml:math> with the ATLAS detector (2013)

This Letter reports a measurement of the high-mass Drell-Yan differential cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC. Based on an integrated luminosity of 4.9 fb -1 , the differential cross-section in the Z / * e + e -channel is measured with the ATLAS detector as a function of the invariant mass, m ee , in the range 116 < m ee < 1500 GeV, for a fiducial region in which both the electron and the positron have transverse momentum p T > 25 GeV and pseudorapidity || < 2.5.
Supplementary Table 1 from MYCN-Dependent Expression of Sulfatase-2 Regulates Neuroblastoma Cell Survival (2023)

&lt;p&gt;Sequences of primers used for RT-PCR.&lt;/p&gt;
Immune-Related Transcriptome of Coptotermes formosanus Shiraki Workers: The Defense Mechanism (2013)

Formosan subterranean termites, Coptotermes formosanus Shiraki, live socially in microbial-rich habitats. To understand the molecular mechanism by which termites combat pathogenic microbes, a full-length normalized cDNA library and four Suppression Subtractive Hybridization (SSH) libraries were constructed from termite workers infected with entomopathogenic fungi (Metarhizium anisopliae and Beauveria bassiana), Gram-positive Bacillus thuringiensis and Gram-negative Escherichia coli, and the libraries were analyzed. From the high quality normalized cDNA library, 439 immune-related sequences were identified. These sequences were categorized as pattern recognition receptors (47 sequences), signal modulators (52 sequences), signal transducers (137 sequences), effectors (39 sequences) and others (164 sequences). From the SSH libraries, 27, 17, 22 and 15 immune-related genes were identified from each SSH library treated with M. anisopliae, B. bassiana, B. thuringiensis and E. coli, respectively. When the normalized cDNA library was compared with the SSH libraries, 37 immune-related clusters were found in common; 56 clusters were identified in the SSH libraries, and 259 were identified in the normalized cDNA library. The immune-related gene expression pattern was further investigated using quantitative real time PCR (qPCR). Important immune-related genes were characterized, and their potential functions were discussed based on the integrated analysis of the results. We suggest that normalized cDNA and SSH libraries enable us to discover functional genes transcriptome. The results remarkably expand our knowledge about immune-inducible genes in C. formosanus Shiraki and enable the future development of novel control strategies for the management of Formosan subterranean termites.
Investigation on the compositionally graded Hf/sub x/Al/sub y/O/sub z/ films for TiN based DRAM capacitor (2005)

New concept of capacitor dielectric thin film was successfully demonstrated through graded Hf/sub x/Al/sub y/O/sub z/ dielectric thin film accompanied by post ozone annealing for the application to DRAM capacitor. MIM capacitor with graded Hf/sub x/Al/sub y/O/sub z/ dielectric films showed drastically reduced leakage current and highly improved breakdown voltage by 0.45-0.75V maintaining the same EOT value. In the case of graded film with Hf/Al=1.5/1, EOT showed very small value of 12.3/spl Aring/ and leakage current could be maintained as low as 1E/sup -16/A/cell at +1.0V.
A nanoplasmonic label-free surface-enhanced Raman scattering strategy for non-invasive cancer genetic subtyping in patient samples (2017)

Simple nucleic acid detection methods could facilitate the progress of disease diagnostics for clinical uses. An attractive strategy is label-free surface-enhanced Raman scattering (SERS) due to its capability of providing structural fingerprinting of analytes that are close to or on nanomaterial surfaces. However, current label-free SERS approaches for DNA/RNA biomarker detection are limited to short and synthetic nucleic acid targets and have not been fully realized in clinical samples due to two possible reasons: (i) low target copies in limited patient samples and (ii) poor capability in identifying specific biomarkers from complex samples. To resolve these limitations and enable label-free SERS for clinical applications, we herein present a novel strategy based on multiplex reverse transcription-recombinase polymerase amplification (RT-RPA) to enrich multiple RNA biomarkers, followed by label-free SERS with multivariate statistical analysis to directly detect, identify and distinguish between these long amplicons (∼200 bp). As a proof-of-concept clinical demonstration, we employed this strategy for non-invasive subtyping of prostate cancer (PCa). In a training cohort of 43 patient urinary samples, we achieved 93.0% specificity, 95.3% sensitivity, and 94.2% accuracy. We believe that our proposed assay could pave the way for simple and direct label-free SERS detection of multiple long nucleic acid sequences in patient samples, and thus facilitate rapid cancer molecular subtyping for personalized therapies.
Microfluidic system for synthesis of nanofibrous conductive hydrogel and muscle differentiation (2017)

Microscale hydrogels can be synthesized within microfluidic systems and subsequently assembled to make tissues composed of units such as myofibers in muscle tissue. Importantly, the nanofibrous surface of hydrogels is essential for tissue engineering aims due to inducing beneficial cell-surface interactions. In this study, a new microfluidic platform, embedded with a hydrogel, was introduced that allowed for performing multiple non-parallel steps for the synthetic approaches. Satellite cells, isolated from skeletal tissues of 10-day Naval Medical Research Institute-murine were cultured on the prepared hydrogel within the microfluidic system. The normal proliferation of satellite cells occurred after the employment of continuous perfusion cell culture. Interestingly, the positive results of the immuno-staining assay along with the cellular bridge formation between hydrogel fragments confirmed the muscle differentiation of seeded satellite cells. Further on, COMSOl simulations anticipated that the thermodynamic conditions of the microfluidic system during hydrogel synthesis had to be kept steady while a shear stress value of 15 × 10<sup>-6</sup> Pa was calculated, exhibiting a cell culture condition free of environmental stress.