gebhart/patrepeval huggingface dataset:
Effect of Dielectric Permittivity on Infinite Arrays of Single-Polarized Vivaldi Antennas (2006)

The effect of dielectric substrate on the performance of infinite arrays of single-polarized Vivaldi antennas is studied by computing the input impedance of an antenna in an array environment by using full wave method of moments techniques. It is found that dielectric permittivity plays an important role in the wideband performance of such arrays, and comparison with dielectric-free cases for similar geometries is also included to bring out the impact of the substrate. In particular, increasing dielectric permittivity improves the bandwidth considerably (bandwidth up to 10:1 is predicted). The parametric variation due to permittivity is presented in detail, and optimization involving other design parameters is discussed. Results from a parallel plate waveguide simulator technique employed to assess and compare the array performance of Vivaldi with different dielectric permittivities qualitatively support the predicted effect of dielectric substrate.
Composition And Structure Of Bimodal WC-Co Materials Related To Mechanical Properties And Abrasive Wear (2015)

This study performs the comprehensive analysis with regards to the amount of ultrafine WC grains needed for the appropriate reinforcement of the metallic binder in WC-8Co cemented carbides. The rat ...
Hypersensitivity reaction to intravitreal clindamycin therapy (2002)

A Caucasian woman presenting with recurrence of intra-ocular toxoplasmosis was given intravitreal clindamycin. She subsequently developed a hypersensitivity reaction in the form of a generalized erythematous rash. To the authors' knowledge, hypersensitivity reactions to an antibiotic given by the intra-vitreal route have not previously been reported.
A Striking Property of Genetic Code-like Transformations (2001)

The gene expression process in nature evaluates the tness of a DNA through the production of different proteins in different cells. The production of protein from DNA goes through transcription that first produces the mRNA and subsequently translates the mRNA to the amino acid sequence in protein. The construction of protein is accomplished by mapping the mRNA sequence using a transformation called the genetic code. This code considers every consequent triplet (codon) of nucleic acids in the mRNA sequence and maps it to a corresponding amino acid. This paper shows that genetic code-like transformations introduce very interesting properties to the representation of a genetic fitness function. This paper presents a Fourier analysis of genetic code-like transformations. It points out that such transformations can convert a function representation of exponential description in Fourier basis to a description that is highly suitable for polynomial complexity approximation. Ge...
Integration of computer-aided automated analysis algorithms in the development and validation of immunohistochemistry biomarkers in ovarian cancer (2020)

In an era when immunohistochemistry (IHC) is increasingly depended on for histological subtyping, and IHC-determined biomarker informing rapid treatment choices is on the horizon; reproducible, quantifiable techniques are required. This study aimed to compare automated IHC scoring to quantify 6 DNA damage response protein markers using a tissue microarray of 66 ovarian cancer samples. Accuracy of quantification was compared between manual H-score and computer-aided quantification using Aperio ImageScope with and without a tissue classification algorithm. High levels of interobserver variation was seen with manual scoring. With automated methods, inclusion of the tissue classifier mask resulted in greater accuracy within carcinomatous areas and an overall increase in H-score of a median of 11.5% (0%-18%). Without the classifier, the score was underestimated by a median of 10.5 (5.2-25.6). Automated methods are reliable and superior to manual scoring. Fixed algorithms offer the reproducibility needed for high-throughout clinical applications.
Targeting Palbociclib-Resistant Estrogen Receptor-Positive Breast Cancer Cells via Oncolytic Virotherapy (2019)

While clinical responses to palbociclib have been promising, metastatic breast cancer remains incurable due to the development of resistance. We generated estrogen receptor-positive (ER+) and ER-negative (ER-) cell line models and determined their permissiveness and cellular responses to an oncolytic adenovirus (OAd) known as Ad5/3-delta24. Analysis of ER+ and ER- palbociclib-resistant cells revealed two clearly distinguishable responses to the OAd. While ER+ palbociclib-resistant cells displayed a hypersensitive phenotype to the effects of the OAd, ER- palbociclib-resistant cells showed a resistant phenotype to the OAd. Hypersensitivity to the OAd in ER+ palbociclib-resistant cells correlated with a decrease in type I interferon (IFN) signaling, an increase in viral entry receptor expression, and an increase in cyclin E expression. OAd resistance in ER- palbociclib-resistant cells correlated with an increase in type I IFN signaling and a marked decrease in viral entry receptor. Using the OAd as monotherapy caused significant cytotoxicity to both ER+ and ER- palbociclib-sensitive cell lines. However, the addition of palbociclib increased the oncolytic activity of the OAd only in ER+ palbociclib-sensitive cells. Our studies provide a mechanistic base for a novel anti-cancer regimen composed of an OAd in combination with palbociclib for the treatment of ER+ breast cancer.
Mode Jumps and Hysteresis in Surface-Wave Sustained Microwave Discharges (1997)

Various electromagnetic surface modes along a finite area dielectric interface can sustain large area overdense plasmas. Mode jumps between these modes have been reported when changing the gas pressure. In this paper we report similar mode jumps caused by changing the wave power at fixed gas pressure. A simple theoretical analysis is proposed to explain this phenomenon on the basis of the resonance behavior of the chamber impedance and a stability criterion is formulated. The theory predicts a hysteresis in the power-density dependence, which was also observed experimentally.
Atypical Plasmacytic Proliferation in a Case of C3 Glomerulopathy (2017)

An 11-year-old Hispanic female underwent evaluation of asymptomatic proteinuria and hematuria. The patient denied fever, edema, and gross hematuria. Urinalysis showed mild proteinuria, and a urine microscopic examination revealed red blood cells. Screening tests for glomerulonephritis revealed a low C3 and negative ANA, ASO, DNAse-B, and ANCA. Histological examination of a renal biopsy specimen showed glomeruli with endocapillary proliferation, a predominant C3 deposition in the capillary loops by immunofluorescence, and electron dense deposits in the mesangium, paramesangium, and capillary walls by electron microscopy consistent with a diagnosis of C3 glomerulopathy. An interstitial plasmacytosis was also present with focal clustering of plasma cells, which were found to be kappa light chain restricted by in situ hybridization suggestive of a clonal proliferation. One can speculate that these plasma cells may be directly responsible for the renal pathology that was seen.
Quality of Life Self‐Assessment as a Function of Lateralization of Lesion in Candidates for Epilepsy Surgery (2001)

A high level of anxiety shown by LTLE patients may represent a personality trait and cause a response bias in overreporting of negative symptoms and a decreased self-assessment of QOL. It may also present a presurgical risk factor, particularly for patients with LTLE lesions. Appropriate patient counseling is advised.
Linear Round Bit-Decomposition of Secret-Shared Values (2014)

In the field of signal processing in the encrypted domain, linear operations are usually easy to perform, whereas multiplications, and bitwise operations like comparison, are more costly in terms of computation and communication. These bitwise operations frequently require a decomposition of the secret value into bits. To minimize the communication complexity, previous studies have focused on solutions that require a constant number of communication rounds, often at the cost of a large number of multiplications. We develop a bit-decomposition protocol within a linear secret sharing system, where sharings of the bits are computed from an integer that is secret-shared among multiple parties. We consider new solutions that require fewer multiplications, but where the number of communication rounds is linear in the input size. Although our basic solution requires m communication rounds to extract the m least significant bits, we present a way of reducing it by an arbitrary factor, using additional precomputations. Given that the best constant round solutions need at least 23 communication rounds, our solution is preferable for integers up to 165 bits, leading to fewer rounds and a smaller number of secure multiplications. In one variant, it is even possible to compute all I bits through only one opening and one additional communication round containing l multiplications, when a precomputation phase of 2 + log <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> I rounds and 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">I</sup> -l-1 secure multiplications has been performed.
Development of a 1 T cryocooler-cooled pulse coil with a Bi2223 superconducting parallel conductor for SMES (1999)

The authors designed and fabricated a 1 T cryocooler-cooled pulse coil operating at 40 K. A 4-strand interlayer-transposed parallel conductor composed of Bi-2223 rectangular cross-sectional multifilamentary wires was adopted to realize a uniform current distribution and to reduce the AC loss density down to the level of that of a single strand. The pulse coil is a 16-layer solenoidal one with an inner diameter of 52 mm, an outer diameter of 111 mm and a height of 120 mm. The heat drains of AlN plates, which are insulators, are arranged between layers for the cooling of the heat due to the AC loss by heat conduction. They could continuously operate the coil in a triangular waveform mode with an amplitude of 1 T and a frequency of 1 Hz. The AC loss was 10.6 W and the other thermal load was 13 W.
Challenges and opportunities in the rural development plan for Malta (2007)

Malta became part of the European Union in May 2004. On the&#13;\n23rd June 2004, the first Rural Development Plan for Malta was&#13;\napproved. This plan was designed to establish a concrete base&#13;\nplatform through which the Maltese agriculture sector could&#13;\nevolve and develop. The plan provided for the growth and de·&#13;\nvelopment of the sector in a sustainable manner applying guide,&#13;\nlines and procedures common to the rest of the other European&#13;\nMember States. This plan recommended that the overall strategy&#13;\nfor Maltese agriculture should focus on the development&#13;\nand specialisation of agricultural niche quality products that are&#13;\nbest suited for the Maltese agro,ecosystems, The 2004·2006 Rural&#13;\nDevelopment Plan was the first ever serious attempt to put&#13;\ntogether a series of measures capable of acUng and reacting in&#13;\nsynChrony to achieve measurable results.&#13;\nThe second Rural Development Plan 2007-2013 aspires to implement&#13;\na strategy that builds upon the achievements and mile,&#13;\nstones of the first Plan. It seeks to offer a more deliverable pro,&#13;\ngramme that IS well aware of the strengths of the rural sector&#13;\nwhile at the same time addressing relevant weaknesses in order&#13;\nto attain a more sustainable development of agriculture. The in,&#13;\nelusion of past, as well as recent experiences both from a technical&#13;\nand from an administrative point of view will strengthen&#13;\nthe commitment in focusing on present and future needs of all&#13;\nstakeholders as well on current European and world trends.&#13;\nThe objective of this paper is to highlight the challenges and opportunities&#13;\nthat are present in the Rural Development Plan (RDP)&#13;\nfor Malta 2007 -2013.
Mobile-Edge Computing Architecture: The role of MEC in the Internet of Things (2016)

Mobile-Edge computing (MEC) is an emerging technology currently recognized as a key enabler for 5G networks. Compatible with current 4G networks, MEC will address many key uses of the 5G system, motivated by the massive diffusion of the Internet of Things (IoT). This article aims to provide a tutorial on MEC technology and an overview of the MEC framework and architecture recently defined by the European Telecommunications Standards Institute (ETSI) MEC Industry Specification Group (ISG) standardization organization. We provide some examples of MEC deployment, with special reference to IoT cases, since IoT is recognized as a main driver for 5G. Finally, we discuss the main benefits and challenges for MEC moving toward 5G.
A Case of IgA Vasculitis Deficiency Presenting with Typical Endoscopic Image (2018)

22歳女性．従妹にIgA血管炎の家族歴あり．食事摂取困難な心窩部痛を主訴に受けた上部消化管内視鏡検査（esophagogastroduodenoscopy：EGD）で十二指腸に血豆様発赤を認め，入院となった．第5病日には腹痛増強と消化管出血をきたし，内視鏡像の増悪を認め，血管炎によるものと判断し，ステロイド加療を開始した．ステロイド投与により症状は速やかに軽快し，第13病日に両下腿に皮診が出現するも，症状の増悪はきたさなかった．腹部症状の先行したIgA血管炎は診断に難渋することも多いが，血豆様所見はIgA血管炎に特徴的な内視鏡像と考えられており，早期診断と治療の一助となる可能性がある．
A Depletion-Mode a-IGZO TFT Shift Register With a Single Low-Voltage-Level Power Signal (2011)

We proposed and fabricated a new depletion-mode amorphous indium-gallium-zinc-oxide thin-film-transistor (a-IGZO TFT) shift register. Although only one low-voltage-level power signal (VGL) rather than widely used two ones was employed, the depletion-mode a-IGZO TFTs in the proposed shift register were turned off completely due to a series-connected two-transistor structure. The proposed shift register exhibited successfully a high-voltage output pulse. The power consumption of the shift register with ten stages is 1.67 mW at the high-voltage-level power signal of 20 V, the VGL of -5 V, and the clock frequency of 13.9 kHz.
ChemInform Abstract: Organophosphorus‐Functionalized Monomers and Pharmaceutical Intermediates (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Sofosbuvir protects human brain organoids against SARS-CoV-2 (2020)

Abstract COVID-19 was rapidly declared a pandemic by the World Health Organization, only three months after the initial outbreak in Wuhan, China. Early clinical care mainly focused on respiratory illnesses. However, a variety of neurological manifestations in both adults and newborns are also emerging. To determine whether SARS-CoV-2 could target the human brain, we infected iPSC-derived human brain organoids. Our findings show that SARS-CoV-2 was able to infect and kill neural cells, including cortical neurons. This phenotype was accompanied by impaired synaptogenesis. Finally, Sofosbuvir, an FDA-approved antiviral drug, was able to rescue these alterations. Given that there are currently no vaccine or antiviral treatments available, urgent therapies are needed. Our findings put Sofosbuvir forward as a potential treatment to alleviate COVID-19-related neurological symptoms. One Sentence Summary SARS-CoV-2 infection causes neuronal death and impaired synaptogenesis, both rescued by Sofosbuvir treatment.
Screening of cell-virus, cell-cell, gene-gene cross-talks among kingdoms of life at single cell resolution (2021)

Abstract The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) issued a significant and urgent threat to global health. The exact animal origin of SARS-CoV-2 remains obscure and understanding its host range is vital for preventing interspecies transmission. Previously, we have assessed the target cell profiles of SARS-CoV-2 in pets, livestock, poultry and wild animals. Herein, we expand this investigation to a wider range of animal species and viruses to provide a comprehensive source for large-scale screening of potential virus hosts. Single cell atlas for several mammalian species (alpaca, hamster, hedgehog, chinchilla etc.), as well as comparative atlas for lung, brain and peripheral blood mononuclear cells (PBMC) for various lineages of animals were constructed, from which we systemically analyzed the virus entry factors for 113 viruses over 20 species from mammalians, birds, reptiles, amphibians and invertebrates. Conserved cellular connectomes and regulomes were also identified, revealing the fundamental cell-cell and gene-gene cross-talks between these species. Overall, our study could help identify the potential host range and tissue tropism of SARS-CoV-2 and a diverse set of viruses and reveal the host-virus co-evolution footprints.
[A case of pulmonary multicentric Castleman disease which appeared as a very large lesion]. (2011)

A 31-year-old man visited our hospital with a persistent cough. Computed tomography (CT) scans of his chest showed a very large mass and multiple nodular lesions in the right lung field, mediastinal and hilar lymph node enlargement and splenomegaly. Laboratory analysis showed polyclonal hyperimmunoglobulinemia and increased levels of serum C-reactive protein (14.05 mg/dl) and interleukin-6 (44.2 pg/ml). The pathological findings of lung specimens obtained using video-assisted thoracoscopy revealed hyperplasia of the lymphoid follicles with germinal centers, plasma cell infiltration which stained positively with either anti-kappa chain or anti-lambda chain antibodies, and fibrosis in the alveolar septum. We made a diagnosis of multicentric Castleman disease based on high levels of serum IL-6, multiple lymph node enlargement and splenomegaly, although this case had histological findings in common not only with Castleman disease but also with inflammatory myofibroblastic tumor. His abnormal chest radiography findings and laboratory data significantly improved 6 months after his first visit, without any treatment. Multicentric Castleman disease showing a very large mass is extremely rare.
Polyimide/Carbon Nanotubes Composite Films: A Potential for FPCB (2006)

Polyimide/carbon nanotube (CNT) composite films for potential use in more efficient flexible copper clad laminated (FCCL) films for flexible printed circuit boards (FPCB) were prepared by mixing a polyisoimide (PII) solution and a CNT suspension in NMP followed by casting, evaporation, and thermal imidization. The CNTs were modified by a nitric acid treatment in order to improve the thermal and electrical properties as well as to provide good dispersion of the CNTs in a polymer matrix. The formation of functional groups on the modified CNT was confirmed by Raman spectroscopy. Scanning electron microscopy revealed the modified CNTs to be well dispersed in the polyimide matrix with a uniform diameter of ca. 50A. The thermal stability and electrical properties of the films containing the CNTs were greatly improved due to the strong interfacial interaction and good dispersion between the polyimide matrix and modified CNTs. In addition, the thermal expansion coefficient of the composites films, as measured by thermo mechanical analysis, decreased with increasing CNT content, which is favorable for practical use in packaging and FPCB materials.
Confocal reflectance microscopy-guided margin-mapping of melanomas for pre-surgical planning (2004)

Confocal reflectance microscopy may enable real-time in vivo imaging and mapping of the margins of primary cutaneous melanoma. Confocal maps of primary, pigmented and amelanotic cutaneous melanomas show excellent correlation to histology. Subclinical, subsurface tumor margins may be determined for pre-surgical planning, to guide biopsy and excision.
Astaxanthin Inhibits Proliferation of Human Gastric Cancer Cell Lines by Interrupting Cell Cycle Progression (2015)

Astaxanthin inhibits proliferation by interrupting cell cycle progression in KATO-III and SNU-1 gastric cancer cells. This may be caused by the inhibition of the phosphorylation of ERK and the enhanced expression of p27(kip-1).
Successful Retroviral Gene Transfer of Simian Virus 40 T Antigen and Herpes Simplex Virus-Thymidine Kinase into Human Hepatocytes (2001)

Current clinical reports have indicated that hepatocyte transplantation (HTX) could be used in patients with liver failure and in children with liver-based metabolic diseases. One of the major limiting factors of HTX is a serious shortage of donor livers for hepatocyte isolation. To address this issue, we immortalized adult human hepatocytes with a retroviral vector SSR#69 expressing the genes of simian virus 40 large T antigen and herpes simplex virus-thymidine kinase simultaneously. One of the resulting clones, NKNT-3, grew steadily in chemically defined serum-free medium without any obvious crisis and showed the gene expression of differentiated liver functions. Under the administration of 5 microM ganciclovir, NKNT-3 cells stopped proliferation and died in in vitro experiments. We have established a tightly regulated immortal human hepatocyte cell line. The cells could allow the need for immediate availability of consistent and functionally uniform cells in sufficient quantity and adequate quality.
Precast Concrete Models Fabricated with Big Area Additive Manufacturing (2018)

The traditional process of making precast concrete molds requires significant manual labor. The molds are made using hardwood, cost tens of thousands of dollars, and take weeks to build. Once built, a mold will last 5-10 pulls before becoming too heavily degraded to continue use. With additive manufacturing, the same mold can be built in eight hours, post-machined in eight hours, costs about $9000, and is projected to last nearly 200 pulls. Oak Ridge National Laboratory has been working with Big Area Additive Manufacturing (BAAM) to fabricate concrete molds for a new high-rise apartment complex in New York. The molded pieces will form structural window supports for the hundreds of windows in building façade. The magnitude of window molds is where additive manufacturing can shine when producing the geometry. This paper will discuss the methods and findings of using BAAM to replace conventional precast concrete pattern making.
Propagation and mutual information of a nonlinear frequency division multiplexed signal (2018)

Nonlinear signal-noise interaction of a propagating 2-soliton strongly exceeds NFT demultiplexer noise enhancement. In terms of reach a 2-soliton with joint detection of the two discrete spectral amplitudes outperforms a single soliton.
Nucleotide Sequence of the Staphylocoagulase Gene: Its Unique COOH-Terminal 8 Tandem Repeats12 (1987)

The entire staphylocoagulase gene of Staphylococcus aureus strain BB was cloned on a MboI restriction endonuclease fragment inserted into pAT153 plasmid vector. The staphylocoagulase was expressed in Escherichia coli, as judged by the formation of a fibrin halo on an agar plate containing rabbit plasma and bovine fibrinogen. We have determined the complete nucleotide sequence of the staphylocoagulase gene by the dideoxynucleotide chain termination method. The deduced amino acid sequence consisted of 715 residues including a signal peptide of 26 residues. Therefore, the predicted molecular weight of the mature protein was 77,337. This sequence was corroborated by reference to the amino acid compositions of 30 lysyl endopeptidase peptides and the sequences of 12 of these peptides isolated from the purified staphylocoagulase. The 5'-flanking region was found to contain a putative Shine-Dalgarno sequence and a putative "-10" element for transcription. The COOH-terminal stretch of 216 amino acids of staphylocoagulase was composed of 8 tandem repeats each consisting of 27 amino acid residues. The amino acid sequence of staphylocoagulase derived from strain BB showed 57% identity with that of the chymotryptic 43-kDa fragment of staphylocoagulase isolated previously from strain 213 (Kawabata, S., Miyata, To., Morita, T., Miyata, Ta., Iwanaga, S., & Igarashi, H. (1986) J. Biol. Chem. 261, 527-531).