gebhart/patrepeval huggingface dataset:
Inter-domain Traffic Conditioning Agreement (TCA) Exchange Attribute (2018)

Network administrators typically enforce Quality of Service (QoS)
policies according to Traffic Conditioning Agreement (TCA) with their
providers. The enforcement of such policies often relies upon vendor-
specific configuration language. Both learning of TCA, either thru TCA
documents or via some other out-of-band method, and translating them
to vendor specific configuration language is a complex, often manual,
process and prone to errors. This document specifies an optional
transitive attribute to signal TCA parameters in-band, across
administrative boundaries (considered as Autonomous Systems (AS)),
thus simplifying and facilitating some of the complex provisioning
tasks in situations where BGP is available as a routing protocol.
Mode of action of β-carboline convulsants on the insect nervous system and their potential as insecticides (1997)

Little information is available on the actions of β-carboline convulsants on insect GABA receptors or their potential as insecticides. Accordingly, two compounds (3-ethoxy-β-carboline, 3-EBC; dimethoxy-β-carboline-3-methyl ester, DMCM) were studied for their effects on Drosophila melanogaster larval neuron discharge and also in lethality bioassays on adult female D. melanogaster and adult male Blattella germanica. Recordings of nerve spiking in the isolated larval central nervous system showed that 3-EBC and DMCM inhibited nerve discharge, and this inhibitory effect was not additive with that of GABA, confirming that the inhibition was expressed through an action on the GABA receptor. Nerve blockage induced by β-carbolines could not be reversed by picrotoxinin, indicating that there may exist some overlap or negative allosteric coupling between the picrotoxinin and β-carboline binding sites. DMCM and 3-EBC effectively antagonized the effects of exogenously applied GABA in nerve preparations from insecticide-susceptible larvae. In contrast, preparations from the rdl strain of D. melanogaster, which possesses a GABA receptor that is highly resistant to cyclodienes and related convulsants, were less sensitive to the GABA antagonist effect of DMCM. Neither of the β-carbolines produced any appreciable mortality in insects, even when synergized with piperonyl butoxide or S,S,S-tributyl phosphorotrithioate, The toxicity of the β-carbolines is probably limited by their relatively weak effects on the GABA receptor and perhaps also by pharmacokinetic factors. These considerations, coupled with the cross-resistance observed in cyclodiene-resistant insects, suggest that the currently available β-carbolines are not viable as lead compounds for insecticide screening efforts. © 1997 SCI.
Parameters distinguishing herpes simplex virus type 2-transformed tumorigenic and nontumorigenic rat cells. (1981)

Abstract A newly developed experimental model system was used to determine in vitro transformation-specific parameters which correlate with tumorigenicity. The data suggested that clonal herpes simplex virus type 2-transformed syngeneic rat embryo cells with intermediate, transformed rat embryo fibroblasts (t-REF-G-1) or high, rat fibrosarcoma tumorigenic potential in syngeneic rats could be differentiated from clonal transformed nontumorigenic (t-REF-G-2) and nontransformed rat embryo fibrobiast cells by their growth to increased saturation density and cloning efficiency in soft-agar medium. All clonal herpes simplex virus type 2-transformed cells, regardless of tumorigenic potential, possessed an increased rate of hexose transport and plasminogen activator activity and were less fibroblastoid in morphology compared to nontransformed rat embryo fibroblast cells. There was no significant difference in cell-doubling time or total phospholipid composition between clonal transformed tumorigenic, nontumorigenic, and nontransformed cells. However, all clonal herpes simplex virus type 2-transformed cell lines possessed a decreased percentage of arachidonic acid and an increased percentage of monounsaturates compared to percentages in nontransformed rat embryo fibroblast cells. Saturation density, cloning efficiency, and tumorigenicity in newborn and adult rats of one nontumorigenic clonal cell line (t-REF-G-2) increased with cell passage in tissue culture. Other transformation-specific biochemical parameters (hexose transport, plasminogen activator activity, and fatty acid composition) remained stable with in vitro passage of the clonal cell lines. Five subclonal cell lines established from 12- O -tetradecanoylphorbol-13-acetate-treated clonal t-REF-G-2 (low passage) cells showed increased cloning efficiencies compared to 2 subclonal cell lines from mock-treated cells; also, all 5 subclonal cell lines from 12- O -tetradecanoylphorbol-13-acetate-treated clonal cells were tumorigenic in newborn rats. Subclonal cell lines from mock-treated clonal cells were non-tumorigenic. It was clear from the results that the absolute cloning efficiency did not correlate with tumorigenicity. This is an important conclusion, since it suggests that quantitation of transformation-specific characteristics at a given point in time will not necessarily be indicative of the tumorigenic potential of the cells.
Isolation and assessment of phytate‐hydrolysing bacteria from the DelMarVa Peninsula (2007)

The Delaware-Maryland-Virginia (DelMarVa) Peninsula, flanking one side of the Chesapeake Bay, is home to a substantial broiler chicken industry. As such, it produces a significant amount of manure that is typically composted and spread onto local croplands as a fertilizer. Phytate (myo inositol hexakisphosphate), the major form of organic phosphorus in the manure, can be hydrolysed by microorganisms to produce orthophosphate. Orthophosphate is a eutrophication agent which can lead to algal blooms, hypoxia and fish kills in the Chesapeake Bay and its tributaries. This transect study reveals a subpopulation of heterotrophic, thiosulfate-utilizing bacteria that can degrade phytate within the watershed as well as its receiving water sediment. Aerobic isolates were typical soil bacteria, e.g. Pseudomonad, Bacillus and Arthrobacter species, as well as a less common Staphylococcus inhabitant. Bacillus pumilus, Staphyloccocus equorum, Arthrobacter bergei and Pseudomonas marginalis strains have not been previously described as phytate-degrading. Each site along the transect - from manure pile to receiving sediment - was host to a population of bacteria that can degrade phytate and hence, each is a possible non-point source of orthophosphate pollution. Each new isolate could provide an enzyme additive for monogastric feed, thus reducing the impact of excessive phytate load on the environment.
Preparation of &lt;small&gt;D&lt;/small&gt;-Gulose from Disaccharide Lactitol Using Microbial and Chemical Methods (2013)

When an M31 strain of Agrobacterium tumefaciens was grown in a mineral salt medium at 30 °C containing 1.0% lactitol as sole carbon source, a keto-sugar was efficiently accumulated in the supernatant. This oxidation from lactitol to the keto-sugar was caused by M31 cells grown with medium containing a disaccharide unit, including sucrose, lactitol, lactose, maltose, or maltitol, suggesting that the enzyme is inducible. M31 also demonstrated good growth characteristics in Tryptic Soy Broth (TSB) medium containing 1.0% sucrose, and cells grown under these conditions showed strong lactitol transformation activity. The keto-sugar product was reduced by chemical hydrogenation and the resulting product was hydrolyzed to D-gulose, D-galactose, and D-sorbitol by acid hydrolysis, revealing that the reduced products are lactitol and D-gulosyl-(β-1,4)-D-sorbitol. Taken together, these results indicate that M31 can convert lactitol to 3-ketolactitol and thus provide access to the rare sugar D-gulose.
Supplementary Figure from Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma (2023)

Supplementary Figure from Ultrasmall Nanoparticle Delivery of Doxorubicin Improves Therapeutic Index for High-Grade Glioma
Circular beams from slab lasers (2006)

A novel resonator concept that produces a circular output beam and highly-elliptical cavity mode suitable for slab lasers is presented, including preliminary results for a diode-bar-pumped Nd:YLF slab laser. Prospects for power scaling are considered.
Total Synthesis of (−)-Cylindrocyclophane F (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTTotal Synthesis of (−)-Cylindrocyclophane FAmos B. Smith, Sergey A. Kozmin, and Daniel V. PaoneView Author Information Department of Chemistry, Monell Chemical Sciences Center, and Laboratory on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104 Cite this: J. Am. Chem. Soc. 1999, 121, 32, 7423–7424Publication Date (Web):July 27, 1999Publication History Received10 May 1999Published online27 July 1999Published inissue 1 August 1999https://doi.org/10.1021/ja991538bCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views2106Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (54 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Aromatic compounds,Hydrocarbons,Metathesis,Organic compounds Get e-Alerts
Freshwater Ichnocoenoses from Triassic Red Beds of East Greenland: ABSTRACT (1977)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Investigating dynamical deformations of tumor cells in circulation: predictions from a theoretical model (2012)

It is inevitable for tumor cells to deal with various mechanical forces in order to move from primary to metastatic sites. In particular, the circulating tumor cells that have detached from the primary tumor and entered into the bloodstream need to survive in a completely new microenvironment. They must withstand hemodynamic forces and overcome the effects of fluid shear before they can leave the vascular system (extravasate) to establish new metastatic foci. One of the hypotheses of the tumor cell extravasation process is based on the so called "adhesion cascade" that was formulated and observed in the context of leukocytes circulating in the vascular system. During this process, the cell needs to switch between various locomotion strategies, from floating with the blood stream, to rolling on the endothelial wall, to tumor cell arrest and crawling, and finally tumor cell transmigration through the endothelial layer. The goal of this project is to use computational mechanical modeling to investigate the fundamental biophysical parameters of tumor cells in circulation. As a first step to build a robust in silico model, we consider a single cell exposed to the blood flow. We examine parameters related to structure of the actin network, cell nucleus and adhesion links between the tumor and endothelial cells that allow for successful transition between different transport modes of the adhesion cascade.
Corticotropin release inhibiting factor is encoded within prepro-TRH (1995)

Corticotropin synthesis and secretion is under negative feedback regulation by glucocorticoids. In addition a hypothalamic factor inhibiting ACTH synthesis and secretion, named corticotropin release inhibiting factor (CRIF), has been postulated but not identified. Here we report that transient transfection of a rat prepro-TRH cDNA into the mouse anterior pituitary tumor cell line AtT-20 inhibits the synthesis and secretion of both basal and CRH-stimulated ACTH. Thus, CRIF appears to be encoded by the same precursor as TRH, suggesting a coordinated regulation of pituitary-adrenal and pituitary-thyroid functions.
Longitudinal Keystroke Biometric Studies on Long-Text Input (2008)

Pace University’s keystroke biometric system is able to identify individuals with a high degree of accuracy. A relatively new dichotomy model system has been developed to support studies of keystroke biometric authentication, and preliminary results with this system have shown promise. The current study extends those authentication experiments and examines the consistency of an individual’s keystroke patterns over periods of week and years, expanding upon a small preliminary longitudinal study carried out on four subjects in the fall of 2007. Results of the preliminary study suggest that an individual’s typing patterns do not change significantly over a period of 2 to 4 weeks. The current study repeats the fall 2007 experiments with a larger sample size, and begins to examine the consistency of typing patterns over a longer period of approximately two years. The study also provides new data on keystroke patterns in a set of identical twins, shedding light on the extent to which keystroke patterns may be biologically determined. 1.
[IgG autoantibodies against cellular p72 antigen crossing with (MLV) p15-gag antigen: presence in early HIV 1 infection, in HBV infection and in primary Gougerot-Sjögren]. (1992)

IgG antibodies of autoimmune SLE (Systemic Lupus Erythematosus) serum S detected a HeLa hnRNP 72 kDa protein, cross-reacting with the retroviral (MLV) p15-gag polypeptide. Since serum S disclosed a ubiquitous 72 kDa antigen in HeLa cell fractions, was prepared the so-called cytoplasmic "X fraction", enriched for the 72 kDa protein, defined here as p72. This autoantigen was detected by antibodies of HIV 1+ patients, recently of seroconverted (RSC) asymptomatic subjects, of HBV+ sera, and of primary Gougerot-Sjögren (prGS) sera. The presence of these autoantibodies in different autoimmune and infectious pathologies raises the question of the involvement of p72 in the immune processes and in the early HIV1 infection.
Cementless Fixation Is Associated With Increased Risk of Early and All-Time Revision After Hemiarthroplasty But Not After THA for Femoral Neck Fracture: Results From the American Joint Replacement Registry (2021)

Level III, therapeutic study.
Control of Distannoxane Structure by Silicon‐Containing Spacers (2000)

In the reaction of [Me3SiCH2(Cl2)SnCH2SiMe2]2Y (Y = CC, O) with (tBu2SnO)3 the SiMe2 groups control the formation of dimeric tetraorgano-distannoxanes. The syntheses and molecular structures are reported of the unsymmetric hydroxy-substituted distannoxane dimer 7 and the symmetric distannoxane dimer 8b. Compounds of this type may serve as homogeneous catalysts in various organic reactions.
Structure-Property Relationships in Epoxy Hybrid Networks Based on High Mass Fraction Pendant POSS Incorporated at Molecular Level (2018)

Abstract Epoxy hybrid networks containing up to 50 wt.% pendant polyhedral oligomeric silsesquioxane (POSS) dispersed at molecular level are prepared by polymerizing DGEBA-POSS precursors with 4,4′-diaminodiphenylmethane (DDM). A high molecular weight control precursor was prepared without pendant POSS cage to quantify the effect of pendant POSS cage on network free volume, number of crosslinks per unit volume and glass transition temperature. Differential scanning calorimetry (DSC) shows drastic decrease in T g with increasing pendant POSS content. The T g value of hybrid network containing 50wt.% POSS is 100 °C lower than the DGEBA-DDM network compare to 77 °C for epoxy network prepared by high molecular weight control precursor (without POSS cage). In order to establish structure-property correlations, these variations have been correlated with free volume, crosslinking density, and chain packing in the network. For the epoxy hybrid networks containing up to 50wt% pendant POSS, the storage modulus of the glassy state (−50 °C) are lower than that of the DGEBA-DDM network, indicating that incorporation of pendant POSS at molecular level increases the spacing and free volume between the chains, and provides them freedom to promote motions. Also, lower storage modulus values in the rubbery state suggest there is no nano-reinforcement effect of POSS cages even at a very high loading (50wt%). Thermogravimetric analysis (TGA) and cone calorimetry show the POSS containing epoxy nanocomposites display high ceramic yields, suggesting the flame retardant behavior of the materials is improved by the molecular level dispersion of pendant POSS. A total of 62% increase in char yield and 53% decrease in peak heat release rate (PHRR) during combustion were observed in hybrid network containing 50wt% POSS compared to DGEBA-DDM network. This study gives new insights into the effects of structural changes in POSS containing thermosets on their performance properties.
Current and future perspectives in psychiatric drug discovery (2009)

On March 12, 2009, the Society for Medicines Research held a 1-day meeting entitled Current and Future Perspectives in Psychiatric Drug Discovery at GlaxoSmithKline, Harlow, U.K. The meeting, organized by Wendy Alderton, Eric Karran and Simon Ward, brought together experts from industry and academia to review the current challenges in the treatment of depression, schizophrenia and addiction. Recent advances in the development of novel agents for the treatment of these diseases were also presented.
Angiodysplasia in Transposed Colon (1988)

A 40-year-old man with a history of colonic transposition for lye stricture at 10 years of age presented with upper gastrointestinal tract bleeding due to angiodysplasia in a transposed right colon.
PC-SPES down-regulates COX-2 via inhibition of NF-κB and C/EBPβ in non-small cell lung cancer cells (2006)

Aberrant expression of COX-2 occurs in many types of malignancies including colon and lung cancers, and is implicated in development and progression of cancer. The molecular mechanisms associated with aberrant expression of COX-2 in lung cancer cells remain to be fully elucidated. In this study, we found that non-small cell lung cancer (NSCLC) NCI-H520 and NCI-H460 cells constitutively expressed COX-2 and produced prostaglandin E2 (PGE2) as measured by Western blotting and enzyme-linked immunosorbent assay (ELISA), respectively. Reporter assays showed that transcriptional regulation of COX-2 was blunted when either the NF-IL6 (C/EBPbeta) or nuclear factor-kappaB (NF-kappaB) binding site in the COX-2 promoter was mutated, suggesting that C/EBPbeta and NF-kappaB transcription factors have an important role in aberrant expression of COX-2 in these lung cancer cells. In addition, the eight herbal mixture PC-SPES (Lot. 5431219) caused growth arrest and apoptosis of NCI-H520 and NCI-H460 cells in association with blockade of NF-kappaB and down-regulation of C/EBPbeta, resulting in down-regulation of COX-2 and PGE2 in these cells. On the other hand, PC-SPES up-regulated the level of C/EBPbeta in these cells. Taken together, C/EBPbeta and NF-kappaB may be promising molecular targets for COX-2 inhibition in lung cancer cells. PC-SPES might be useful in the adjuvant setting for the treatment of individuals with resected NSCLC as well as other types of cancer in which COX-2 is activated.
Polyethylenimine Coated Carbon Nanotube For Detecting Rancidity In Frying Oil (2011)

Chemical detection is still a continuous challenge when it comes to designing single-walled carbon nanotube (SWCNT) sensors with high selectivity, especially in complex chemical environments. A perfect example of such an environment would be in thermally oxidized soybean oil. At elevated temperatures, oil oxidizes through a series of chemical reactions which results in the formation of monoacylglycerols, diacylglycerols, oxidized triacylglycerols, dimers, trimers, polymers, free fatty acids, ketones, aldehydes, alcohols, esters, and other minor products. In order to detect the rancidity of oxidized soybean oil, carbon nanotube chemiresistor sensors have been coated with polyethylenimine (PEI) to enhance the sensitivity and selectivity. PEI functionalized SWCNTs are known to have a high selectivity towards strong electron withdrawing molecules. The sensors were very responsive to different oil oxidation levels and furthermore, displayed a rapid recovery in ambient air without the need of heating or UV exposure.
Hypoxia-Responsive Subtype Cells Differentiate Into Neurons in the Brain of Zebrafish Embryos Exposed to Hypoxic Stress (2022)

Severe hypoxia results in complete loss of central nervous system (CNS) function in mammals, while several other vertebrates, such as zebrafish, can regenerate after hypoxia-induced injury of CNS. Since the cellular mechanism involved in this remarkable feature of other vertebrates is still unclear, we studied the cellular regeneration of zebrafish brain, employing zebrafish embryos from transgenic line <i>huORFZ</i> exposed to hypoxia and then oxygen recovery. GFP-expressing cells, identified in some cells of the CNS, including some brain cells, were termed as hypoxia-responsive recovering cells (HrRCs). After hypoxia, HrRCs did not undergo apoptosis, while most non-GFP-expressing cells, including neurons, did. Major cell types of HrRCs found in the brain of zebrafish embryos induced by hypoxic stress were neural stem/progenitor cells (NSPCs) and radial glia cells (RGs), that is, subtypes of NSPCs (NSPCs-HrRCs) and RGs (RGs-HrRCs) that were induced by and sensitively responded to hypoxic stress. Interestingly, among HrRCs, subtypes of NSPCs- or RGs-HrRCs could proliferate and differentiate into early neurons during oxygen recovery, suggesting that these subtype cells might play a critical role in brain regeneration of zebrafish embryos after hypoxic stress.
Biochemical methane potential of microalgae biomass using different microbial inocula (2018)

Overall, this study showed that working with tailored anaerobic microbiome could help avoiding pretreatments devoted to methane yield enhancement.
Kinetics study and crystallization process design for scale‐up of UiO‐66‐NH<sub>2</sub> synthesis (2012)

A comprehensive scale‐up procedure for amine‐functionalized UiO‐66 is implemented, which leads to the development of a novel flow‐through metal‐organic framework synthesis process. Products are characterized via BET modeling of N 2 adsorption at 77 K and powder XRD to confirm crystal porosity and phase, respectively. Batch syntheses are conducted to examine the effects of polytetrafluoroethylene and glass vessel materials on crystal yield and quality. Intermediate samples from sealed‐vessel trials at 373, 383, and 393 K are collected and characterized, which show a high degree of product consistency. Nucleation rates are determined at the same temperatures, and the Arrhenius relationship is used to predict the activation energy of nucleation, E aNuc . A continuous‐flow reactive crystallization process is developed using a draft‐tube type reactor. As a proof of concept, the reactor is operated for three retention times. The cumulative product, material retained within the crystallizer, and intermediate samples are collected and characterized to confirm UiO‐66‐NH 2 production. © 2012 American Institute of Chemical Engineers AIChE J, 59: 1255–1262, 2013