gebhart/patrepeval huggingface dataset:
Query-Age-Optimal Scheduling Under Sampling and Transmission Constraints (2023)

This letter provides query-age-optimal joint sampling and transmission scheduling policies for a heterogeneous status update system, consisting of a stochastic arrival and a generate-at-will source, with an unreliable channel. Our main goal is to minimize the average query age of information (QAoI) subject to average sampling, average transmission, and per-slot transmission constraints. To this end, an optimization problem is formulated and solved by casting it into a linear program. We also provide a low-complexity near-optimal policy using the notion of weakly-coupled constrained Markov decision processes. The numerical results show up to 32% performance improvement by the proposed policies compared with a benchmark policy.
Metabotropic Glutamate 2/3 Receptor Agonists and Positive Allosteric Modulators of Metabotropic Glutamate Receptor 2 as Novel Agents for the Treatment of Schizophrenia (2012)

The origin of modern psychopharmacology can be traced to the discovery of the first clinically efficacious antipsychotic drug, chlorpromazine, in 1952. Following this watershed advance, several additional antipsychotic agents of the same (i.e., phenothiazine) class, as well as others derived from the butyrophenone scaffold (e.g., haloperidol, 1958), were discovered and widely utilized in the treatment of schizophrenia patients. Arvid Carlsson and his colleagues were the first to show that antipsychotics of both the phenothiazine and butyrophenone classes acted via blockade of dopamine (DA) receptors [1]. This hypothesis was further refined over a decade later by observations that all antipsychotic drugs potently block dopamine D2-like receptors [2, 3]. Interest in moving to mechanisms of antipsychotic action other than dopamine D2
Geoid anomalies due to low-viscosity zones in glacial isostatic adjustment modeling (2003)

Earth oriented research in the group belongs to Delft Earth Oriented Space Research (DEOS
Effect of Carrier Frequency Offset on Offset QAM Multicarrier Filter Bank Systems over Frequency-Selective Channels (2010)

This paper presents an analysis of the effect of carrier frequency offset (CFO) on offset QAM (OQAM) multicarrier filter bank (MCFB) systems, also known as staggered modulated multitone (SMT), over frequency-selective channels. This effect may be quantified by signal-to-interference ratio (SIR). We drive an accurate expression for the interference power and the desired signal power. Then SIR of SMT systems is calculated. Next, we drive an approximated SIR when the maximum delay of the channel is small in comparison with symbol spacing. The approximated SIR show that the SIR over frequency-selective channels converges to that over additive white Gaussian noise (AWGN) channels. Numerical results show that with increasing number of subcarriers, both of accurate and approximated forms of SIR as a function of CFO over frequency-selective channels converge to that over AWGN channels. Also, we compare SMT and orthogonal frequency division multiplexing (OFDM). It is shown that OFDM has better SIR in small CFO over frequency-selective channels. But with large number of subcarriers or high CFO, SMT outperforms OFDM.
Gordonia bronchialis Bacteremia and Pleural Infection: Case Report and Review of the Literature (2011)

Gordonia species are aerobic actinomycetes recently recognized as causing human disease, often in the setting of intravascular catheter-related infections. We describe a case of Gordonia bronchialis bacteremia and pleural space infection in the absence of an indwelling intravascular catheter and review the breadth of reported infections with this emerging pathogen.
ChemInform Abstract: Convenient Transformation of Carbonyl Compounds via Their Hydrazones ( I) into gem‐Difluoro Compounds (II) with N‐Bromosuccinimide/Pyridinium Poly(hydrogen Fluoride) or Poly‐4‐vinylpyridinium Poly(hydrogen Fluoride). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Impaired Dynamic Balance Control in Adolescents With Idiopathic Scoliosis and Abnormal Somatosensory Evoked Potentials (2008)

Diagnostic study, level IV (case-control study).
Comparison of the Width of Sound Sources in 2-Channel and 3-Channel Sound Reproduction (2010)

In this paper, we present the result of listening tests where the width of the sound stage was compared between conventional 2-channel stereophony and 3-channel reproduction with an additional centre loudspeaker. When listeners were seated at the axis of symmetry, there was no significant difference between the two cases. On the off-axis positions there was a clear trend that the perceived image width of the noise is influenced by the way an additional interfering stimulus is reproduced, which was found to depend on the correlation of the noise. The results suggest that the spatial attribute of one sound image may be affected by another, for which possible explanations based on the principles of binaural hearing will be discussed.
Is perception isomorphic with neural activity? (1994)

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Investigation and comparative study of the quantum molecular descriptors derived from the theoretical modeling and Monte Carlo simulation of two new macromolecular polyepoxide architectures TGEEBA and HGEMDA (2018)

Our objective is to compare the performance of the quantum parameters of two new synthesized multifunctional polymeric architectures: triglycidyl ether ethylene of bisphenol A (TGEEBA) and hexaglycidyl ethylene of methylene dianiline (HDEMDA). Calculations have been performed with Gaussian software package and the prediction of the quantum molecular descriptors of the two new macromolecular matrices are namely: the energy of the highest occupied molecular orbital (EHOMO), the energy of the lowest molecular orbital (ELUMO), the ionization potanial (IP), the electron affinity (EA), gap energy (ΔE), softness (σ), electronegativity (χ), hardness (ƞ), the electrophilic character (ω) and the function of the transferred electrons of coating on the surface of the metal (ΔN), etc. These were calculated by the functional density theory method (DFT) with 6–311 G (d, p) basis sets. The local reactivity of two polymers has been studied through the Fukui indices. Indeed, we conclude that the matrix HGEMDA has a low value of the adsorption energy than that of the TGEEBA, indicating that this polymer has a high adsorption capacity on the metal surface. Finally, the results obtained by the Monte Carlo simulation are in very good agreement with the data of the theory of the DFT.
MO-FG-CAMPUS-IeP3-03: Optimal Parameters to Determine the Apparent Diffusion Coefficient in Diffusion Weighted Imaging Via Simulation (2016)

Purpose: To investigate in silico how calculation of apparent diffusion coefficient (ADC) is affected by image SNR, b-values, and the true tissue ADC. Methods: Diffusion-weighted (DW) images were generated assuming a mono-exponential signal model with two different b-values and known true ADC values. Rician noise of different levels was added to the DWI images to adjust the image SNR. Using the two DWI images, ADC was calculated using a mono-exponential model for each set of b-values, SNR, and true ADC. 40,000 simulations were performed for each parameter setting to determine the mean and the standard-deviation of the calculated ADC, as well as the percentage accuracy and precision with respect to the true ADC. In our study, we simulated two true ADCs (ADC 0.00102 for prostate tumor and 0.00180 mm2/s for normal prostate tissue). SNR was varied from 2 to 100 and b-values were varied from 0 to 2000s/mm2. Results: The accuracy (difference between known and calculated ADC) and precision (standard-deviation of calculated ADC) were increased with SNR. To increase SNR, 10 signal-averagings (NEX) were used. The optimal NEX combination for tumor and normal tissue was 2, 8, and the optimal b-value pair were 0, 1200s/mm2 and 0, 700s/mm2. The minimum accuracy and precision errors were obtained when low b-value is 0. For any choice of low b-value until 400s/mm2, the errors were minimized when b-value difference is approximately 1200 and 700s/mm2 for tumor and normal tissues respectively. For true ADC < 0.00144 mm2/s accuracy and precision improves when high b-value is around 1200s/mm2. Otherwise, for true ADC > 0.00144 mm2/s, it is around 700s/mm2. Conclusion: Using the optimal choices of parameters for the prostate peripheral region both normal and tumor tissues were calculated with 99% accuracy and 94% precision. Suggestions for parameters choices could be made for any tissue ADC.
CD4<sup>+</sup>CD25<sup>+</sup>Regulatory T Cells Impair HIV-1-Specific CD4 T Cell Responses by Upregulating Interleukin-10 Production in Monocytes (2012)

T cell dysfunction in the presence of ongoing antigen exposure is a cardinal feature of chronic viral infections with persistent high viremia, including HIV-1. Although interleukin-10 (IL-10) has been implicated as an important mediator of this T cell dysfunction, the regulation of IL-10 production in chronic HIV-1 infection remains poorly understood. We demonstrated that IL-10 is elevated in the plasma of individuals with chronic HIV-1 infection and that blockade of IL-10 signaling results in a restoration of HIV-1-specific CD4 T cell proliferation, gamma interferon (IFN-γ) secretion, and, to a lesser extent, IL-2 production. Whereas IL-10 blockade leads to restoration of IFN-γ secretion by HIV-1-specific CD4 T cells in all categories of subjects investigated, significant enhancement of IL-2 production and improved proliferation of CD4 T helper cells are restricted to viremic individuals. In peripheral blood mononuclear cells (PBMCs), this IL-10 is produced primarily by CD14(+) monocytes, but its production is tightly controlled by regulatory T cells (Tregs), which produce little IL-10 directly. When Tregs are depleted from PBMCs of viremic individuals, the effect of the IL-10 signaling blockade is abolished and IL-10 production by monocytes decreases, while the production of proinflammatory cytokines, such as tumor necrosis factor alpha (TNF-α), increases. The regulation of IL-10 by Tregs appears to be mediated primarily by contact or paracrine-dependent mechanisms which involve IL-27. This work describes a novel mechanism by which regulatory T cells control IL-10 production and contribute to dysfunctional HIV-1-specific CD4 T cell help in chronic HIV-1 infection and provides a unique mechanistic insight into the role of regulatory T cells in immune exhaustion.
The Influence of Uber on the Tourism Industry in Sub-Saharan Africa (2020)

An unreliable and inefficient public transportation system can be a barrier to the successful development of a destination’s tourism industry. Uber, a convenient ride-hailing service, can complement underdeveloped public transport and play a significant role in stimulating the tourism economy by increasing tourists’ mobility and accessibility to attractions and service facilities. Using the data of 48 sub-Saharan African countries, this study conducted propensity score matching and difference-in-differences analysis to empirically examine the influence of Uber on a country’s tourism industry. The results showed that Uber contributed $20 million annually in total tourist spending—$24 per tourist spending—on average, to a country’s economy between 2013 and 2016. However, it did not have a significant influence on the number of international arrivals. The findings of this study provided insights into the benefits of Uber service in promoting per tourist spending by providing a reliable and efficient means of travel.
Synchronizing Spatiotemporal Chaos of Partial Differential Equations (1997)

A general approach for synchronizing pairs of unidirectionally coupled partial differential equations (PDEs) with spatiotemporally chaotic dynamics is introduced. We show that for a large class of PDEs, a pair of PDEs can be synchronized by driving the response system only at a finite number of space points. We also discuss the relevance of our results for control of spatiotemporal chaos.
Histochemistry of Mucosubstances in the Mantle of the Clam, Mercenaria mercenaria. II. MucoSubstances in the Second Marginal Fold (1969)

Robert E. Hillman, Histochemistry of Mucosubstances in the Mantle of the Clam, Mercenaria mercenaria. II. MucoSubstances in the Second Marginal Fold, Transactions of the American Microscopical Society, Vol. 88, No. 3 (Jul., 1969), pp. 420-425
A Numerical Method to Solve a Phaseless Coefficient Inverse Problem from a Single Measurement of Experimental Data (2018)

The goal of this paper is to develop a globally convergent numerical method for the inverse problem which would work with the optical experimental data collected by this research group. Only the intensity (modulus square) of the total complex valued wave field is measured at an array of light detectors located on a measurement plane. The phase is not measured. We solve numerically the phaseless coefficient inverse problem to reconstruct locations and refractive indices of unknown scatterers from those measurements. Our method consists of two stages. In the first stage, we obtain an upper estimate for the modulus of the scattered wave field. This estimate allows us to approximately reconstruct the wave field at the measurement plane using a resulting inversion formula. This reduces the phaseless inverse scattering problem to the phased one. In the second stage, we apply a recently developed globally convergent numerical method to reconstruct the desired refractive index from the total wave obtained at the first stage. Unlike the optimization approach, our two-stage numerical method is global in the sense that it does not require a good initial guess of the true solution. A significant part of this work is devoted to testing our numerical method on both computationally simulated and experimental data.
Influence of External Loads on Thin Film Cracking (2004)

Cracking in thin films under the combined influence of residual stress and an external load is examined. An improved accuracy version of the existing solution for substrate cracking absent the external load is provided. A superposition scheme that uses the solution for substrate cracking and other existing published solutions is presented for the determination of the energy release rate. The superposition scheme is validated using finite element analysis, and conditions under which the superposition scheme is valid are discussed. Crack arrest is examined and two parameters that determine the possibility of crack arrest are identified. The influence of external loading on channelling behavior in the substrate is discussed.
Research Article Actions of a Series of PPADS Analogs at P2X1 and P2X3 Receptors (2001)

Seven PPADS ( yridoxal-5'- hosphate 6- zophenyl 2',4'- i ulfonate) analogs were investi- gated at Group 1 P2X receptors expressed in Xenopus oocytes. All seven analogs potently inhibited P2X1 (IC50 range, 5-32 nM) and P2X3 (IC50 range, 22-345 nM), the two Group I P2X receptor subtypes. Analogs showed greater inhibitory activity where the pyridoxal moiety of PPADS contained a 5'-phosphonate group, rather than a 5'-phosphate group. Analogs also showed greater potency where disulfonate groups were removed from, or substituted at, the azophenyl moiety. The most active analog was MRS 2257 (pyridoxal- 5'-phosphonate 6-azophenyl 3',5'-bismethylenephosphonate) at P2X1 (IC50, 5 nM) and P2X3 (IC50, 22 nM) receptors, being 14-fold and 10-fold more potent than PPADS itself. MRS 2257 produced a nonsurmountable inhibition when tested against a range of ATP concentrations, although blockade was reversed by about 85% after 20 minutes of washout. TNP-ATP and Ip5I were equipotent with MRS 2257 at P2X1 receptors, whereas TNP-ATP was 64-fold more potent than MRS 2257 at P2X3 receptors. In conclusion, the PPADS template can be altered at the pyridoxal and phenyl moieties to produce P2X1 and P2X3 receptor antagonists showing higher potency and greater degree of reversibility than the parent compound at these Group I P2X receptors. Drug Dev. Res. 53:281-291, 2001. © 2001 Wiley-Liss, Inc.
Switchable resolution in soft x-ray tomography of single cells (2020)

The diversity of living cells, in both size and internal complexity, calls for imaging methods with adaptable spatial resolution. Soft x-ray tomography (SXT) is a three-dimensional imaging technique ideally suited to visualizing and quantifying the internal organization of single cells of varying sizes in a near-native state. The achievable resolution of the soft x-ray microscope is largely determined by the objective lens, but switching between objectives is extremely time-consuming and typically undertaken only during microscope maintenance procedures. Since the resolution of the optic is inversely proportional to the depth of focus, an optic capable of imaging the thickest cells is routinely selected. This unnecessarily limits the achievable resolution in smaller cells and eliminates the ability to obtain high-resolution images of regions of interest in larger cells. Here, we describe developments to overcome this shortfall and allow selection of microscope optics best suited to the specimen characteristics and data requirements. We demonstrate that switchable objective capability advances the flexibility of SXT to enable imaging cells ranging in size from bacteria to yeast and mammalian cells without physically modifying the microscope, and we demonstrate the use of this technology to image the same specimen with both optics.
The promiscuous binding of the Fyn SH3 domain to a peptide from the NS5A protein (2012)

The hepatitis C virus nonstructural 5A (NS5A) protein is a large zinc-binding phosphoprotein that plays an important role in viral RNA replication and is involved in altering signal transduction pathways in the host cell. This protein interacts with Fyn tyrosine kinase in vivo and regulates its kinase activity. The 1.5 Å resolution crystal structure of a complex between the SH3 domain of the Fyn tyrosine kinase and the C-terminal proline-rich motif of the NS5A-derived peptide APPIPPPRRKR has been solved. Crystals were obtained in the presence of ZnCl(2) and belonged to the tetragonal space group P4(1)2(1)2. The asymmetric unit is composed of four SH3 domains and two NS5A peptide molecules; only three of the domain molecules contain a bound peptide, while the fourth molecule seems to correspond to a free form of the domain. Additionally, two of the SH3 domains are bound to the same peptide chain and form a ternary complex. The proline-rich motif present in the NS5A protein seems to be important for RNA replication and virus assembly, and the promiscuous interaction of the Fyn SH3 domain with the NS5A C-terminal proline-rich peptide found in this crystallographic structure may be important in the virus infection cycle.
Analytical and Preparative Separation of Geometrical Isomers by High Efficiency Silver Nitrate Liquid Chromatography (1977)

A packing technique in which carbon tetrachloride is the dispersing agent was used to pack high performance liquid chromatographic columns with 5 μsilica gel. The efficiencies obtained with analytical and preparative silica columns and AgNO3-coated silica columns packed by this technique were compared. Special considerations were taken to minimize losses in column efficiency due to the chromatographic system. The AgNO3-coated silica columns enabled the rapid separation of geometrical isomers of pheromones both analytically and preparatively. The highly efficient AgNO3 silica columns gave baseline separations of some isomers on a column 5 cm in length and resulted in the development of a column in which the percentage of impregnated silver ion was critical to the separation.
Smart Devices in Airbnbs: Considering Privacy and Security for both Guests and Hosts (2020)

Abstract Consumer smart home devices are becoming increasingly pervasive. As Airbnb hosts deploy smart devices in spaces shared with guests, we seek to understand the security and privacy implications of these devices for both hosts and guests. We conducted a large-scale survey of 82 hosts and 554 guests to explore their current technology practices, their preferences for smart devices and data collection/sharing, and their privacy and security concerns in the context of Airbnbs. We found that guests preferred smart devices, even viewed them as a luxury, but some guests were concerned that smart devices enable excessive monitoring and control, which could lead to repercussions from hosts (e.g., locked thermostat). On average, the views of guests and hosts on data collection in Airbnb were aligned, but for the data types where differences occur, serious privacy violations might happen. For example, 90% of our guest participants did not want to share their Internet history with hosts, but one in five hosts wanted access to that information. Overall, our findings surface tensions between hosts and guests around the use of smart devices and in-home data collection. We synthesize recommendations to address the surfaced tensions and identify broader research challenges.
Effect of the solid phase on the global phase behavior of Lennard–Jones mixtures (2004)

Abstract Complete phase diagrams, that is, showing the solid, liquid, and vapor phases, are calculated for 29 binary mixtures of Lennard–Jones molecules characterized by different sets of interaction parameters using the Gibbs–Duhem integration technique. The impact of including the possibility of a solid phase on the global phase behavior of such mixtures is investigated by comparing the complete phase behavior calculated by simulation to the global phase diagram calculated from a fluid‐phase‐only equation of state. Complete phase diagrams from each region of the global phase diagram are presented and compared with the fluid‐phase‐only phase behavior for the same mixture. It is found that for mixtures in which the components have greatly dissimilar critical temperatures, the presence of the solid phase significantly alters the fluid‐phase equilibria. In those cases, the phase behavior classification based on experimental observations should differ from that predicted by an equation‐of‐state approach. © 2004 American Institute of Chemical Engineers AIChE J, 50: 1948–1960, 2004
Ifosfamide-based chemotherapy for previously treated lung cancer patients. (1998)

The study results suggest that ifosfamide chemotherapy is active with an acceptable toxicity profile in previously treated SCLC patients. However, it lacks efficacy in NSCLC patients who have been previously treated.
Spherical Large Intelligent Surfaces (2020)

As an emerging technology and evolution that goes beyond massive multi-input multi-output (MIMO), large intelligent surface (LIS) has gained much interest. LIS acts as an electromagnetic surface that can transmit, redirect, and receive radiating signals across its entire contiguous surface. It allows for unprecedented energy-focusing, data-transmission and terminal-positioning, and can fulfill the most grand visions for future communication systems. Earlier proposed LISs are in two-dimensional (2D), i.e., planar shapes. In this paper, we extend LISs to be three-dimensional (3D) and deployed as spherical surfaces. Compared to 2D LIS, a spherical LIS has advantages in wide coverage, simple positioning technique, and flexible deployment as reflecting surface.