gebhart/patrepeval huggingface dataset:
Incorporation of Naked Peptide Nucleic Acids into Liposomes Leads to Fast and Efficient Delivery (2015)

The delivery of peptide nucleic acids (PNAs) to cells is a very challenging task. We report here that a liposomal formulation composed of egg PC/cholesterol/DSPE-PEG2000 can be loaded, according to different encapsulation techniques, with PNA or fluorescent PNA oligomers. PNA loaded liposomes efficiently and quickly promote the uptake of a PNA targeting the microRNA miR-210 in human erythroleukemic K562 cells. By using this innovative delivery system for PNA, down-regulation of miR-210 is achieved at a low PNA concentration.
Strong Domain Variation and Treebank-Induced LFG Resources (2005)

In this paper we present a number of experiments to test the portability of existing treebankinduced LFG resources. We test the LFG parsing resources of Cahill et al. (2004) on the ATIS corpus which represents a considerabley different domain to the Penn-II Treebank Wall Street Journal sections, from which the resources were induced. This testing shows an underperformance at both c- and f-structure level as a result of the domain variation. We show that in order to adapt the LFG resources of Cahill et al. (2004) to this new domain, all that is necessary is to retrain the c-structure parser on data from the new domain.
Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B cells through a PI3-kinase–dependent pathway (2009)

Chronic lymphocytic leukemia (CLL) involves a profound humoral immune defect and tumor-specific humoral tolerance that directly contribute to disease morbidity and mortality. CD154 gene therapy can reverse this immune defect, but attempts to do this pharmacologically have been unsuccessful. The immune-modulatory agent lenalidomide shows clinical activity in CLL, but its mechanism is poorly understood. Here, we demonstrate that lenalidomide induces expression of functional CD154 antigen on CLL cells both in vitro and in vivo. This occurs via enhanced CD154 transcription mediated by a Nuclear Factor of Activated T cells c1 (NFATc1)/Nuclear Factor-kappaB (NF-kappaB) complex and also through phosphoinositide-3 (PI3)-kinase pathway-dependent stabilization of CD154 mRNA. Importantly, CD154-positive CLL cells up-regulate BID, DR5, and p73, become sensitized to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis, and promote costimulatory activation of normal B cells to produce antibodies. In CLL patients receiving lenalidomide, similar evidence of CD154 activation is observed including BID, DR5, and p73 induction and also development of anti-ROR1 tumor-directed antibodies. Our data demonstrate that lenalidomide promotes CD154 expression on CLL cells with subsequent activation phenotype, and may therefore reverse the humoral immune defect observed in this disease. This study is registered at http://clinicaltrials.gov as NCT00466895.
GroundsWell: Community-engaged and data-informed systems transformation of Urban Green and Blue Space for population health – a new initiative (2022)

Natural environments, such as parks, woodlands and lakes, have positive impacts on health and wellbeing. Urban Green and Blue Spaces (UGBS), and the activities that take place in them, can significantly influence the health outcomes of all communities, and reduce health inequalities. Improving access and quality of UGBS needs understanding of the range of systems (e.g. planning, transport, environment, community) in which UGBS are located. UGBS offers an ideal exemplar for testing systems innovations as it reflects place-based and <i>whole society</i> processes <i>,</i> with potential to reduce non-communicable disease (NCD) risk and associated social inequalities in health. UGBS can impact multiple behavioural and environmental aetiological pathways. However, the systems which desire, design, develop, and deliver UGBS are fragmented and siloed, with ineffective mechanisms for data generation, knowledge exchange and mobilisation. Further, UGBS need to be co-designed with and by those whose health could benefit most from them, so they are appropriate, accessible, valued and used well. This paper describes a major new prevention research programme and partnership, <i>GroundsWell</i>, which aims to transform UGBS-related systems by improving how we plan, design, evaluate and manage UGBS so that it benefits all communities, especially those who are in poorest health. We use a broad definition of health to include physical, mental, social wellbeing and quality of life. Our objectives are to transform systems so that UGBS are planned, developed, implemented, maintained and evaluated with our communities and data systems to enhance health and reduce inequalities. GroundsWell will use interdisciplinary, problem-solving approaches to accelerate and optimise community collaborations among citizens, users, implementers, policymakers and researchers to impact research, policy, practice and active citizenship. GroundsWell will be shaped and developed in three pioneer cities (Belfast, Edinburgh, Liverpool) and their regional contexts, with embedded translational mechanisms to ensure that outputs and impact have UK-wide and international application.
Modular design of a high performance 32-bit microcontroller (1989)

A 32-bit microcontroller the MC68332 has been fabricated using a macro-module design approach. This permitted early fabrication and evaluation of the modules as the designs were completed. Interface to the modules was achieved by a common bus interface, which was accessible externally for testing
Posterior Capsular Rupture Causing Posterior Shoulder Instability: A Case Report (2011)

Abstract We report the case of a 20‐year‐old male competitive football player who was treated for a midsubstance posterior capsule rupture after a posterior dislocation from falling onto his shoulder. Conservative management for 5 months after the injury failed to improve his subjective symptoms, with the primary symptom being activity‐related posterior shoulder pain. Advanced imaging findings and physical examination were consistent with posterior instability, thought to be due to a posterior labral tear. At the time of a diagnostic arthroscopy, the patient was found to have an oval‐shaped rupture of the capsule that was neither a reverse humeral avulsion of the glenohumeral ligament lesion nor a posterior labral tear. The capsular tear was repaired through an all‐arthroscopic technique with nonabsorbable sutures. The patient returned to his previous competitive function, had no pain, and had full motion at final follow‐up without recurrence of instability or pain symptoms.
Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease (2015)

HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis.
Efectos del extracto de alcoholes purificados de la cera de abejas (Apis mellifera) en dos modelos de analgesia (2010)

The D-002 is a mixture of 6 high molecular weight aliphatic acids purified from bee wax (Apis mellifera). The aim of present study was to research the effects of an oral treatment using D-002 on the acetic acidinduced abdominal writhings and in the hot plate model in mice. Animals were randomized distributed to 5 groups (1020 animals/group): a control one received the Gum Arabic vehicle/H20, three received D-002 (25, 125 and 250 mg/kg), and another received aspirin (abdominal contortions model) or morphine (hot plate). The D-002 inhibited the above mentioned writhings in a 44., 44,8 and 47. , respectively; however, not modified the response latency in the hot plate model. These results demonstrate that the D002 (25-250 mg/kg) oral treatment may to inhibit in a moderate way the above mentioned writhings without to affect the response to hot plate. It suggests that the D-002 exerts a peripheral analgesic action but not a central level.
Engineering Renewable carbon to bio-based product (2020)

Increased use of bio-based products has the potential to accelerate the shift towards asustainable economy with reduced dependence on fossil based carbon and reduced CO2 emissions. Many countries through International Energy Agency (IEA) Bioenergy Task 42 and Mission Innovation initiatives have targeted development and deployment of integrated bio-refineries for producing sustainable bio-based products using renewable sources of carbon. Renewable carbons can be a combination of first generation (food derived), second generation (non-food derived), third generation (non-land use change) and fourth generation carbon that can be channelled for production of bio-based products for use as food, feed, fuels and materials.The world has substantial amount of under-utilize renewable carbon in the form of non-fodder agricultural wastes and other wastes such as municipal solid wastes, municipal liquid waste and industrial waste that put together have the potential to fully substitute all fossil carbon requirements. Sustainable technology platforms have been designed at DBT-ICT Centre for Energy Biosciences, India using a smart combination of chemical processes and biological routes that can convert different renewable carbons to value added bio-based products. The bio-based products include food and feed products, wellness products, chemicals and polymer precursors. The talk shall address the technological roadblocks that need to be overcome to render the bio-based products techno-commercially viable and environmentally sustainable
Numerical Characterization of Electrohydrodynamic Micro- or Nanopatterning Processes Based on a Phase-Field Formulation of Liquid Dielectrophoresis (2013)

The electrohydrodynamic patterning of polymer is a unique technique for micro- and nanostructuring where an electric voltage is applied to an electrode pair consisting of a patterned template and a polymer-coated substrate either in contact or separated by an air gap to actuate the deformation of the rheological polymer. Depending on the template composition, three processes were proposed for implementing the EHDP technique and have received a great amount of attention (i.e., electrostatic force-assisted nanoimprint, dielectrophoresis-electrocapillary force-driven imprint, and electrically induced structure formation). A numerical approach, which is versatile for visualizing the full evolution of micro- or nanostructures in these patterning processes or their variants, is a desirable critical tool for optimizing the process variables in industrial applications of this structuring technique. Considering the fact that all of these processes use a dielectric and viscous polymer (behaving mechanically as a liquid) and are carried out in ambient air, this Article presents a generalized formulation for the numerical characterization of the EHDP processes by coupling liquid dielectrophoresis (L-DEP) and the phase field of the air-liquid dual phase. More importantly, some major scale effects, such as the surface tension, contact angle, liquid-solid interface slip, and non-Newtonian viscosity law are introduced, which can impact the accuracy of the numerical results, as shown experimentally by our electrical actuation of a dielectric microdroplet as a test problem. The numerical results are in good agreement with or are well explained by experimental observations published for the three EHDP processes.
Positron Annihilation in Alkali Halides at Low Temperatures (1986)

We report on low-temperature positron studies for pure, single crystals of the alkali halides KCl, NaCl and NaF. Strong temperature dependences are observed in the lifetime and angular correlation measurements in the temperature range 10–300 K. Delocalized para-positronium is observed at low temperatures in the three crystals. The broadening, with rising temperature, of the narrow peak in the angular correlation curve can be accounted for by the self-trapping model of positronium. The results are discussed in the light of this model, in terms of positronium localization at imperfections and in terms of positron interactions with imperfections created in the spur of the positron. The increased positronium formation with temperature is viewed as an enhanced escape probability of the excess electrons from sinks competing with positronium formation.
Simple authentication for the web (2007)

Automated email-based password reestablishment (EBPR) is an efficient, cost-effective means to deal with forgotten passwords. In this technique, email providers authenticate users on behalf of web sites. This method works because web sites trust email providers to deliver messages to their intended recipients. Simple Authentication for the Web (SAW) improves upon this basic approach to user authentication to create an alternative to password-based logins. SAW: 1) Removes the setup and management costs of passwords at sites that accept the risks of EBPR; 2) Provides single sign-on without a specialized identity provider; 3) Thwarts all passive attacks.
Supplementary Figure 3 from Characterization of Chemokines and Adhesion Molecules Associated with T cell Presence in Tertiary Lymphoid Structures in Human Lung Cancer (2023)

&lt;p&gt;PDF file - 65KB, Appendix A5.&lt;/p&gt;
Generation of Specific Resistance Profiles in FLT3-ITD and FIP1L1-PDGFRalpha towards Specifically Acting Tyrosine Kinase Inhibitors. (2006)

Abstract BCR-ABL kinase domain mutations constitute the major mechanism of resistance in patients with chronic myelogenous leukemia treated with the ABL kinase inhibitor imatinib. Mutations causing resistance to therapeutic kinase inhibition were also identified in other target kinases in various malignant diseases, such as FLT3-ITD in acute myelogenous leukemia, cKit in gastrointestinal stromal tumors, EGFR in patients with lung cancer, and FIP1L1-PDGFRalpha in hypereosinophilic syndrome. Thus, mutations in kinase domains seem to be a general mechanism of resistance to therapeutically applicated tyrosine kinase inhibitors. We recently developed a cell-based screening strategy that allows one to predict the pattern and relative abundance of BCR-ABL resistance mutations emerging in the presence of imatinib, and the novel ABL kinase inhibitor AMN107 (nilotinib). We therefore intended to determine, if this method would also allow the generation of resistant cell clones with other oncogeneic tyrosine kinases as targets in the presence of specifically acting kinase inhibitors. When FLT3-ITD and su5614 were used as drug/target combination in our cell-based method, the frequency of resistant clones in the presence of su5614 at 10 times the IC50 was 0.17 per million cells. In 40 per cent of resistant clones, point mutations were detected leading to amino acid exchanges within the FLT3-ITD split kinase domain. The yield of resistant clones was increased by the factor of 14 to 2.37 per million cells by adding ethyl-nitrosourea (ENU), a potent inducer of point mutations. Also, the proportion of mutant clones increased from 40 to 74 per cent. In 83 mutant clones that were examined so far, we detected eight exchanges affecting kinase domain two (TK2) of the split kinase domain within or shortly behind the FLT3-ITD activation loop (A-loop). We did not detect exchanges affecting TK1. We next examined whether resistant clones would also come up with FIP1L1-PDGFRalpha-transformed cells in the presence of imatinib. Again, the yield of resistant clones increased when cells were pretreated with ENU, and a proportion of resistant clones contained mutations in the FIP1L1-PDGFRalpha kinase domain, affecting the nucleotide-binding loop (P-loop) and A-loop. We conclude that cell-based resistance screening is a simple and powerful tool that allows prediction of resistance mutations towards kinase inhibitors in various relevant oncogeneic kinases.
Hemodynamic segmentation of MR brain perfusion images using independent component analysis, thresholding, and Bayesian estimation (2003)

Dynamic-susceptibility-contrast MR perfusion imaging is a widely used imaging tool for in vivo study of cerebral blood perfusion. However, visualization of different hemodynamic compartments is less investigated. In this work, independent component analysis, thresholding, and Bayesian estimation were used to concurrently segment different tissues, i.e., artery, gray matter, white matter, vein and sinus, choroid plexus, and cerebral spinal fluid, with corresponding signal-time curves on perfusion images of five normal volunteers. Based on the spatiotemporal hemodynamics, sequential passages and microcirculation of contrast-agent particles in these tissues were decomposed and analyzed. Late and multiphasic perfusion, indicating the presence of contrast agents, was observed in the choroid plexus and the cerebral spinal fluid. An arterial input function was modeled using the concentration-time curve of the arterial area on the same slice, rather than remote slices, for the deconvolution calculation of relative cerebral blood flow.
The FANTOM web resource: from mammalian transcriptional landscape to its dynamic regulation (2009)

In FANTOM4, an international collaborative research project, we collected a wide range of genome-scale data, including 24 million mRNA 5'-reads (CAGE tags) and microarray expression profiles along a differentiation time course of the human THP-1 cell line and under 52 systematic siRNA perturbations. In addition, data regarding chromatin status derived from ChIP-chip to elucidate the transcriptional regulatory interactions are included. Here we present these data to the research community as an integrated web resource.
Topographic nonoverlapping distribution of D<sub>1</sub> and D<sub>2</sub> dopamine receptors in the amygdaloid nuclear complex of the rat brain (1992)

The distribution of D1 and D2 dopamine (DA) receptors in the nuclei and subnuclear zones of the rat amygdaloid complex was mapped using quantitative light microscopic autoradiography. [125I]iodosulpiride and [125I]SCH 23982 (in the presence of 50 nM ketanserin) were used to label D2 and D1 DA receptors, respectively. The DA receptor subtypes exhibited a topographic, nonoverlapping distribution which generally conformed to the cytoarchitectonic boundaries of the component nuclei and subnuclear zones of the amygdaloid complex. The highest density of [125I]iodosulpiride binding sites was observed in the main intercalated cell group and the central amygdaloid nucleus where a medial to lateral gradient of binding sites was localized to its subnuclear zones. [125I]SCH 23982 binding sites were localized in the main intercalated cell group and the basolateral amygdaloid nucleus with a uniform low density in the central nucleus. The functional topography of mesoamygdaloid DA neurons may therefore be mediated, in part, at the level of DA receptor subtypes. The pattern of distribution of [125I]iodosulpiride binding sites in subdivisions of the central amygdaloid nucleus and bed nucleus of the stria terminalis suggests that the functions of the "extended amygdala," a major system of the functional organization of the basal forebrain, may be regulated by DA afferents at multiple key sites of D2 receptor action.
Oxidation in Fish Oil Enriched Mayonnaise:  Ascorbic Acid and Low pH Increase Oxidative Deterioration (2001)

The effect of ascorbic acid (0-4000 ppm) and pH (3.8-6.2) on oxidation and levels of iron and copper in various fractions of mayonnaise enriched with 16% fish oil was investigated. Ascorbic acid induced release of iron from the assumed oil-water interface into the aqueous phase at all pH levels, but this effect of ascorbic acid was strongest at low pH (pH 3.8-4.2). Ascorbic acid generally promoted formation of volatile oxidation compounds and reduced the peroxide value in mayonnaises. Peroxide values and total volatiles generally increased with decreasing pH values, suggesting that low pH promoted oxidation. It is proposed that iron bridges between the egg yolk proteins low-density lipoproteins, lipovitellin, and phosvitin at the oil-water interface are broken at low pH values, whereby iron ions become accessible as oxidation initiators. In the presence of ascorbic acid, oxidation is further enhanced due to the reduction of Fe(3+) to Fe(2+) that rapidly catalyzes lipid oxidation via lipid hydroperoxide decomposition at the oil-water interface in mayonnaise.
The Level of Mastery of Polysemic Words Showing Second Language Learners' English Proficiency (2001)

Ultrasound speckle is a consequence of the stochastic nature of the reflectivity of scattering media (e.g., biological tissue) and of the coherent nature of piezoelectric transducers. This speckle noise can be reduced by the use of incoherent processing techniques (e.g., spatial compounding, incoherent summation, random phase and phase insensitive transducers). We present a unified framework that explains the limitations of incoherent processing in terms of the information grain theory. This theory predicts the gains in SNR as well as the losses in directivity. We also present the random phase transducer approach to incoherence to total coherence. We present applications to speckle reduction, detection of specular reflectors, attenuation estimation and ultrasound imaging. We show that totally incoherent transducers completely remove diffraction effects. They might be used in attenuation estimation, in which case, correction for diffraction is no longer required, in order to obtain unbiased estimates. Partially coherent transducers might also be useful in imaging to reduce speckle noise.
Phase-dependent knee model identification in gait motion using an active knee rehabilitation orthotic device (2011)

International audience
Study of texture, mechanical and electrical properties of cold drawn AGS alloy wire (2016)

An investigation has been done to study the evolution of the microstructure, mechanical and electrical properties of AlMgSi alloy destined for the transport of electric energy, in function of the deformation caused by the cold drawing process. We identified that drawing of aluminum wire causes development of a fibrous texture of type <111> and <100>. We notice also that the electrical resistivity and mechanical resistance increases with the increasing of the deformation level. Characterization methods used in this work is: The Electron Back Scattered Diffraction EBSD, X-Ray diffraction, Vickers microhardness, Tensile test, Measuring electrical resistivity, the Scanning Electron Microscope (SEM) and Energy Diffraction Spectrum (EDS).
A capacity management service for resource pools (2005)

Resource pools are computing environments that offer virtualized access to shared resources. When used effectively they can align the use of capacity with business needs (flexibility), lower infrastructure costs (via resource sharing), and lower operating costs (via automation). This paper describes the Quartermaster capacity manager service for managing such pools. It implements a trace-based technique that models workload (e.g., application) resource demands, their corresponding resource allocations, and resource access quality of service. The primary advantages of the technique are its accuracy, generality, support for resource access qualities of service, and optimizing search method. We pose general capacity management questions for resource pools and explain how the capacity manager helps to address them in an automated manner. A case study demonstrates and validates the method on empirical data from an enterprise application. We show that the technique exploits much of the resource savings to be achieved from resource sharing and is significantly more accurate at estimating per-server required capacity than a benchmark method used in practice to manage a resource pool. Finally, we explain how the problems relate to other practices regarding enterprise capacity management and software performance engineering.