gebhart/patrepeval huggingface dataset:
Opposite Effects of Tor1 and Tor2 on Nitrogen Starvation Responses in Fission Yeast (2006)

The TOR protein kinases exhibit a conserved role in regulating cellular growth and proliferation. In the fission yeast two TOR homologs are present. tor1(+) is required for starvation and stress responses, while tor2(+) is essential. We report here that Tor2 depleted cells show a phenotype very similar to that of wild-type cells starved for nitrogen, including arrest at the G(1) phase of the cell cycle, induction of nitrogen-starvation-specific genes, and entrance into the sexual development pathway. The phenotype of tor2 mutants is in a striking contrast to the failure of tor1 mutants to initiate sexual development or arrest in G(1) under nitrogen starvation conditions. Tsc1 and Tsc2, the genes mutated in the human tuberous sclerosis complex syndrome, negatively regulate the mammalian TOR via inactivation of the GTPase Rheb. We analyzed the genetic relationship between the two TOR genes and the Schizosaccharomyces pombe orthologs of TSC1, TSC2, and Rheb. Our data suggest that like in higher eukaryotes, the Tsc1-2 complex negatively regulates Tor2. In contrast, the Tsc1-2 complex and Tor1 appear to work in parallel, both positively regulating amino acid uptake through the control of expression of amino acid permeases. Additionally, either Tsc1/2 or Tor1 are required for growth on a poor nitrogen source such as proline. Mutants lacking Tsc1 or Tsc2 are highly sensitive to rapamycin under poor nitrogen conditions, suggesting that the function of Tor1 under such conditions is sensitive to rapamycin. We discuss the complex genetic interactions between tor1(+), tor2(+), and tsc1/2(+) and the implications for rapamycin sensitivity in tsc1 or tsc2 mutants.
Ultra-High-Performance Fiber-Reinforced Concrete: Shrinkage Strain Development at Early Ages and Potential for Cracking (2017)

Abstract This study investigates the effects of the concrete-ring thickness and steel fiber on the restrained shrinkage behavior of ultra-high-performance fiber-reinforced concrete (UHPFRC) using the ring test. To do this, three different concrete-ring thicknesses (tc = 20, 30, and 40 mm) and two different fiber contents (Vf = 0 % and 2 %) were considered. The test results indicated that the ring specimen without fiber exhibited shrinkage cracking after nearly 1.4 days because of its low tensile strength, whereas no shrinkage cracking was observed for the ring specimens with fibers during testing. A thicker concrete ring provided lower residual stress, relaxed stress, degree of restraint, and cracking potential. Therefore, it was concluded that using steel fiber and increasing the concrete thickness perpendicular to the tensile stress direction can improve the shrinkage cracking resistance of UHPFRC.
The insertion geometry of the posterolateral corner of the knee (2005)

We have quantitatively documented the insertion geometry of the main stabilising structures of the posterolateral corner of the knee in 34 human cadavers. The lateral collateral ligament inserted posterior (4.6 mm, sd 2) and proximal (1.3 mm, sd 3.6) to the lateral epicondyle of the femur and posterior (8.1 mm, sd 3.2) to the anterior point of the head of the fibula. On the femur, the popliteus tendon inserted distally (11 mm, sd 0.8) and either anterior or posterior (mean 0.84 mm anterior, sd 4) to the lateral collateral ligament. The popliteofibular ligament inserted distal (1.3 mm, sd 1.2) and anterior (0.5 mm, sd 2.0) to the tip of the styloid process of the fibula. The ligaments had a consistent pattern of insertion and, despite the variation between specimens, the standard deviations were less than the typical size of drill hole used in reconstruction of the posterolateral corner. The data provided in this study can be used in the anatomical repair and reconstruction of this region of the knee.
A Two-Dimensional Superconducting Electron Gas in Freestanding LaAlO<sub>3</sub>/SrTiO<sub>3</sub> Micromembranes (2022)

Freestanding oxide membranes constitute an intriguing material platform for new functionalities and allow integration of oxide electronics with technologically important platforms such as silicon. Sambri et al. recently reported a method to fabricate freestanding LaAlO<sub>3</sub>/SrTiO<sub>3</sub> (LAO/STO) membranes by spalling of strained heterostructures. Here, we first develop a scheme for the high-yield fabrication of membrane devices on silicon. Second, we show that the membranes exhibit metallic conductivity and a superconducting phase below ∼200 mK. Using anisotropic magnetotransport we extract the superconducting phase coherence length ξ ≈ 36-80 nm and establish an upper bound on the thickness of the superconducting electron gas <i>d</i> ≈ 17-33 nm, thus confirming its two-dimensional character. Finally, we show that the critical current can be modulated using a silicon-based backgate. The ability to form superconducting nanostructures of LAO/STO membranes, with electronic properties similar to those of the bulk counterpart, opens opportunities for integrating oxide nanoelectronics with silicon-based architectures.
Coherent coupling of a metamaterial resonator with hydrogen-like acceptor impurities in Si (2022)

We investigate the coherent coupling of metamaterial resonators with hydrogen-like boron acceptors in doped Si at cryogenic temperature. When the resonance frequency of the metamaterial superimposes a transition frequency of the acceptors, Rabi splitting is observed. As expected, the splitting shows a square-root dependence on the density of the acceptors. Our experiments open a new route for the investigation of quantum information processes employing strong coupling of dopants in Si.
LAS ESTRATEGIAS DE LECTURA. CONCEPTO Y ENSEÑANZA Reading skills. Concept and teaching Les stratégies de la lecture. Le concept et apprendre (2000)

RESUMEN; Los continuos cambios que la sociedad sufre se convierten en fundamento para desarrollar en nuestros alumnos la capacidad de aprender a aprender Con ello se pretende favorecer un dominio procedimental adecuado que les posibilite un aprendizaje autonomo, el cual garantiza su adaptacion a las necesidades que presente el entorno. Esta perspectiva desemboca en la necesidad de dotar a nuestros alumnos de distintas estrategias de aprendizaje. Hasta el momento, se han seguido dos alternativas paralelas: por un lado los programas estructurados de «ensenar a pensar», y por otro el impulso que la reforma dio a los contenidos procedimentales en el desarrollo curricular. Ambas perspectivas han recibido criticas, f)ero pensamos que ninguno de los analisis presentados ha detectado el origen de esta problematica. Damos una alternativa, desde una nueva vision de que es ensenar estrategias de aprendizaje. No se trata de desarrollar procesos encadenados, que se reproduzcan en situaciones nuevas de ensenanza. Mas bien lo interpretamos como la optimizacion de recursos del sujeto, aplicada a cada una de las realidades a las que este se enfrente, buscando su
Delayed Dosing of Oral Rotavirus Vaccine Demonstrates Decreased Risk of Rotavirus Gastroenteritis Associated With Serum Zinc: A Randomized Controlled Trial (2016)

NCT01375647.
Enhanced durability and reactivity for zinc ferrite desulfurization sorbent. Quarterly technical progress report 8, July--September 1988 (1988)

AMAX Research & Development Center (AMAX R&D) has been investigating methods for enhancing the reactivity and durability of the zinc ferrite desulfurization sorbent. Zinc ferrite sorbents are intended for use in desulfurization of hot coal gas in integrated gasification combined cycle (IGCC) or molten carbonate fuel cell (MCFC) applications. For the present program, the reactivity of the sorbent may be defined as its sulfur sorption capacity at the breakthrough point and at saturation in a bench-scale, fixed-bed reactor. Durability may be defined as the ability of the sorbent to maintain important physical characteristics such As size, strength, and specific surface area during 10 cycles of sulfidation and oxidation.
ChemInform Abstract: Ruthenium Dioxide in Fluoro Acid Medium Part 5. Application to the Nonphenolic Oxidative Coupling of Diarylbutanes. Conformational Studies of cis and trans Deoxyschizandrins. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simple and Fast Rolling Circle Amplification-Based Detection of Topoisomerase 1 Activity in Crude Biological Samples (2022)

Isothermal amplification-based techniques such as the rolling circle amplification have been successfully employed for the detection of nucleic acids, protein amounts, or other relevant molecules. These methods have shown to be substantial alternatives to PCR or ELISA for clinical and research applications. Moreover, the detection of protein amount (by Western blot or immunohistochemistry) is often insufficient to provide information for cancer diagnosis, whereas the measurement of enzyme activity represents a valuable biomarker. Measurement of enzyme activity also allows for the diagnosis and potential treatment of pathogen-borne diseases. In all eukaryotes, topoisomerases are the key DNA-binding enzymes involved in the control of the DNA topological state during important cellular processes and are among the important biomarkers for cancer prognosis and treatment. Over the years, topoisomerases have been substantially investigated as a potential target of antiparasitic and anticancer drugs with libraries of natural and synthetic small-molecule compounds that are investigated every year. Here, the rolling circle amplification method, termed rolling circle enhanced enzyme activity detection (REEAD) assay that allows for the quantitative measurement of topoisomerase 1 (TOP1) activity in a simple, fast, and gel-free manner is presented.By cleaving and ligating a specially designed DNA substrate, TOP1 converts a DNA oligonucleotide into a closed circle, which becomes the template for rolling circle amplification, yielding ~10<sup>3</sup> tandem repeat rolling circle products. Depending on the nucleotide incorporation during the amplification, there is the possibility of different readout methods, from fluorescence to chemiluminescence to colorimetric. As each TOP1-mediated cleavage-ligation generates one closed DNA circle, the assay is highly sensitive and directly quantitative.
The second solar spectrum. A new window for diagnostics of the Sun (1997)

The Sun's radiation becomes linearly polarized by coherent scattering processes in the solar atmosphere. With a novel polarimetry system that achieves a precision of 10 5 in the degree of polarization, the previously largely unexplored territory of scattering physics on the Sun is now fully acces- sible. The observations reveal a polarized spectrum that looks very different as compared with the ordinary, unpolarized solar spectrum but has an astounding wealth of spectral structures. It is therefore refered to as the \second solar Inthepresentpaperweshowhowthesecondsolarspectrum is governed by different physical processes, which provide new diagnostic opportunities and tools that are complementary to those of the ordinary intensity spectrum. We illustrate the ef- fects of quantum interferences and hyperne structure, isotope abundances, partial frequency redistribution, molecular contri- butions, and magnetic canopies. Also shown are polarization features,forwhichtheunderlyingphysicshasnotyetbeeniden- tied.
ChemInform Abstract: Vinyl Carbanions. Part 41. Diastereoselectivity in Center‐Face Interaction of Reactants. Synthesis of Tetronic Acid Derivatives from β‐C‐Lithiated Acrylates and Aldehydes and Methylation of 5‐Deprotonated 4‐Amino‐2(5H)‐furanones. (1990)

Abstract The optically active methyl acrylate (I) reacts with acetaldehyde (II) in the presence of lithium diisopropylamide to produce the methylfuranone (III) as the main product.
INTRATHYMIC DELETION OF ALLOREACTIVE T CELLS IN MIXED BONE MARROW CHIMERAS PREPARED WITH A NONMYELOABLATIVE CONDITIONING REGIMEN1 (1998)

Tolerance to transplantation antigens is achieved through intrathymic deletion of donor-reactive T cells in mixed chimeras prepared with a nonmyeloablative conditioning regimen and allogeneic bone marrow transplantation.
Detection of <i>Pistacia vera</i> adulteration by using laser induced breakdown spectroscopy (2018)

The results of the present study demonstrate that LIBS with the chemometric methods showed a good performance based on the high value of prediction accuracy for pistachio adulteration. This technique has high potential as a rapid method for pistachio identification and detection of adulteration. © 2018 Society of Chemical Industry.
Rhodium Supported Hβ Zeolite for the Hydrogenation of Toluene (2008)

Noble metal Rh supported on a large pore high acidic zeolite Hβ has been explored as a hydrodearomatization catalyst. The detail kinetic study of hydrodearomatization of toluene over a 1 wt % Rh/Hβ was done in a continuous-downflow stainless steel catalytic fixed bed reactor at varied space time, toluene feed rate, hydrogen partial pressure, hydrogen to toluene mole ratio, temperature, and in the presence of dibenzothiophene. The time on stream data and reaction order with respect to toluene were measured and was found to be of first order. Fourier transform infrared (FTIR) spectra and chemical analysis of fresh and spent catalyst suggested the presence of surface carbon species and weight percent carbon was found to be 4.43%. It was observed that toluene conversion was increased on increasing H2 partial pressure and H2/feed mole ratio. The conversion is dependent on temperature and shows a well-defined maximum. The decrease of the catalyst activity in the presence of dibenzothiophene is mainly attributed to the adsorption and decomposition of dibenzothiophene (DBT) on the metal sites, which results in a loss of metal surface available for the reaction to take place and a higher coke formation reducing the fraction of acid sites available for toluene hydrodearomatization. A nonlinear semiempirical kinetic model was also developed to have the best fit with 12% error.
Ultra-high brightness electron beams from very-high field cryogenic radiofrequency photocathode sources (2018)

Recent investigations of RF copper structures operated at cryogenic temperatures performed by a SLAC-UCLA collaboration have shown a dramatic increase in the maximum surface electric field, to 500 MV/m. We examine use of these fields to enable very high field cryogenic photoinjectors that can attain over an order of magnitude increase in peak electron beam brightness. We present beam dynamics studies relevant to X-ray FEL injectors, using start-to-end simulations that show the high brightness and low emittance of this source enables operation of a compact FEL reaching a photon energy of 80 keV. The preservation of beam brightness in compression, exploiting micro-bunching techniques is discussed. While the gain in brightness at high field is due to increase of the emission current density, further increases in brightness due to lowering of the intrinsic cathode emittance in cryogenic operation are also enabled. While the original proposal for this type of cryogenic, ultra-high field photoinjector has emphasized S-band designs, there are numerous potential advantages that may be conferred by operation in C-band. We examine issues related to experimental implementation in C-band, and expected performance of this type of device in a future hard X-ray FEL such as MaRIE.
Formulation of the term refinement problem for user-oriented information retrieval (2003)

A framework called the user-oriented information retrieval system is introduced. The framework enables the retrieval system to be adaptive in the sense that not only the structuring and organization of documents, but also their representation can be dynamically modified through feedback. An important problem that arises in this context is one of determining the significance for retrieval of index terms assigned to documents. This problem, called the term refinement problem, is formulated rigorously. It is shown that there is a direct correspondence between this problem and the well known
Conservation of the Optical Properties of SRO after CMOS IC Processing (2014)

The Silicon rich silicon oxide (SRO) is a CMOS compatible material that present light emission properties when annealed at high temperatures to produce the silicon segregation process. This material can be used to integrate optoelectronics circuits. However, during the CMOS fabrication process there are thermal processes that could alter the characteristics of this material. Moreover, in the same way thermal treatments needed for efficient light emission in the SRO could damage the electronic circuits. Then, special care has to be paid when SRO devices with optical functions and CMOS with electronic control circuits are integrated. In this paper, it is shown how a silicon sensor cover with a SRO layer and various electronic CMOS circuits were fabricated simultaneously. Details of how the SRO film was protected to avoid it to be damage, and how the SRO film was deposited and annealed in order to maintain the electronic circuitry working, are given. Experimental details of the optical properties and the electronic functionality are displayed. So, it is possible to integrate the SRO film and electronic functions in silicon IC successfully.
Radiation Transfer in a Cylindrical Vessel Containing High-Temperature Corium Aerosols (1986)

Radiation transfer is relevant to a number of key technical issues related to nuclear reactor safety studies. To gain understanding of thermal radiation transfer under hypothetical reactor accident conditions, analysis of radiation transfer in a finite length cylindrical vessel containing high-temperature aerosols that absorb, emit, and scatter thermal radiation has been performed. The fine particles are assumed to be produced by the dispersion of the reactor core debris under high pressure. The model parameters used in the calculations correspond to those proposed in the High-Pressure Melt Streaming experimental program. Results of calculations show that the extinction coefficient and the single scattering albedo of the aerosol and the emissivity of the vessel are important model parameters. The sensitivity studies have identified the radiative property data base needed to make realistic radiative transfer calculations relevant to hypothetical reactor accidents in which fine aerosol particles are generated from the core debris.
Summary (2015)

This chapter presents a summary key concepts discussed in the book, which presents the basic guidelines for the long-term evolution (LTE) planning and optimization of the backhaul based on the operator's own strategy and cost structure. The various operators and the different regions have their own particular needs and resources when setting up their backhaul. The amount of end-user activity differs from area to area and the used services vary, based on the needs of individuals, so the traffic load in terms of volume and mix of services is always different. The examples, cases and guidelines in the book helps planners to tackle the many issues found when planning and optimizing a backhaul network or when working with service providers. The book outlines the economical modeling to understand the cost-versus-technology selection and discusses the theory of dimensioning the backhaul.
Medical, psychological and social features in a large cohort of adults with <scp>P</scp>rader–<scp>W</scp>illi syndrome: experience from a dedicated centre in France (2014)

Adult patients with PWS showed high prevalence of comorbid health problems that need to be monitored for early treatment. Some of them are influenced by genotype and age. Another salient problem concerns the lack of adapted structures for better social integration. Further data about the real life and health conditions of adults with PWS are necessary to further our knowledge of the natural history of the disease and to design appropriate care strategies.
« Evidence for Self-Healing Effect in a Multi-Layer Glass Coating» (2016)

International audience
Data from Genomic Heterogeneity and the Small Renal Mass (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Tumor heterogeneity may represent a barrier to preoperative genomic characterization by needle biopsy in clear cell renal cell carcinoma (ccRCC). The extent of heterogeneity in small renal tumors remains unknown. Therefore, we set out to evaluate heterogeneity in resected large and small renal tumors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; We conducted a study from 2013 to 2016 that evaluated 47 consecutive ccRCC tumors resected during radical or partial nephrectomy. Cases were designated as small (&lt;4 cm) and large (&gt;7 cm) tumors. Each tumor had three regions sampled. Copy-number variation (CNV) was assessed and gene expression analysis was performed to characterize the clear-cell A and B (ccA/ccB) profile and the cell-cycle progression (CCP) score. Genomic heterogeneity between three regions was evaluated using CNV subclonal events, regional expression profiles, and correlation between gene expression.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Twenty-three small and 24 large tumors were analyzed. Total CNVs and subclonal CNVs events were less frequent in small tumors (&lt;i&gt;P&lt;/i&gt; &lt; 0.001). Significant gene expression heterogeneity was observed for both CCP scores and ccA/ccB classifications. Larger tumors had more variance in CCP scores (&lt;i&gt;P&lt;/i&gt; = 0.026). The distribution of ccA/ccB differed between small and large tumors with mixed ccA/ccB tumors occurring more frequently in the larger tumors (&lt;i&gt;P&lt;/i&gt; = 0.024). Analysis of five mixed tumors (with both ccA/ccB regions) demonstrated the more aggressive ccB phenotype had greater CNV events (&lt;i&gt;P&lt;/i&gt; = 0.014).&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Small renal tumors have much less genomic complexity and fewer subclonal events. Pretreatment genomic characterization with single-needle biopsy in small tumors may be useful to assess biologic potential and may influence therapy. &lt;i&gt;Clin Cancer Res; 24(17); 4137–44. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Disintegrin-Integrin Binding for Attachment of Polymer Substrate to the Retina (2018)

We successfully lased and produced an active area on the silicone surface to allow disintegrin-silicone binding. Different silicones interact differently with the laser energy, and this is reflected in the strength of the silicone-disintegrin-retina attachment.