gebhart/patrepeval huggingface dataset:
O5‐03‐03: Genetic association of progressive supranuclear palsy (PSP) risk loci variants with brain gene expression and neuropathology endophenotypes (2012)

A recent genome-wide association study (GWAS) of PSP risk identified four significant loci near MAPT, STX6, EIF2AK3, and MOBP in addition to three suggestive loci at 1q41 intergenic locus, BMS1 and SLCO1A2. There is a need to uncover the actual risk gene at these loci and the mechanism of the functional variants. Given that regulatory variants that influence gene expression constitute an important class of functional variants, we hypothesize that some of the novel PSP GWAS loci lead to disease risk by modifying brain gene expression. In this study we tested the PSP risk loci variants for their effects on brain gene expression. We also assessed the influence of two of these loci for association with neuropathology endophenotypes. We measured expression levels of 24,526 transcripts in 773 brain samples from the cerebellum and temporal cortex of autopsied subjects with Alzheimer's disease neuropathology (cerebellar-n = 197, temporal_cortex-n = 202) and those with other brain pathologies (cerebellar-n = 177, temporal_cortex-n = 197), including patients with PSP (cerebellar-n = 98, temporal_cortex-n = 107). We conducted an expression genome-wide association study (eGWAS) using 213,528 cisSNPs within 100 kb of the tested transcript. We assessed the seven strongest PSP risk loci in our eGWAS for association with the expression levels of nearby transcripts. Using the semi-quantitative neuropathology scores on 458 autopsied PSP subjects and latent modeling, we obtained quantitative neuropathology endophenotypes. We tested two of the top PSP GWAS loci for neuropathology associations. We found evidence of cis-associations between PSP risk variants and brain expression levels of SLCO1A2, MAPT and MOBP. We tested MAPT rs242557 and MOBP rs1768208 for associations with neuropathology endophenotypes and identified significant and biologically consistent associations. Regulatory variants at SLCO1A2, MAPT and MOBP loci may at least partly explain the PSP risk association at these loci. Furthermore, we identified associations with neuropathology endophenotypes for two variants that were tested. We are in the process of testing the remaining PSP GWAS variants for their effects on neuropathology. These results have implications in the search for functional variants at the novel PSP risk loci.
Supplementary Table 1 from EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis (2023)

Supplementary Table 1 from EZH2-Mediated Concordant Repression of Wnt Antagonists Promotes β-Catenin–Dependent Hepatocarcinogenesis
LANSCE Capabilities (2020)

For more than 40 years the Los Alamos Neutron Science Center (LANSCE) has provided the scientific underpinnings in nuclear physics and material science needed to ensure the safety and surety of the nuclear stockpile into the future. In addition to national security research, the LANSCE User Facility has a vibrant research program in fundamental science, providing the scientific community with intense sources of neutrons and protons to perform experiments supporting civilian research and the production of medical and research isotopes.
Associations of the Fecal Microbial Proteome Composition and Proneness to Diet-induced Obesity (2019)

Consumption of refined high-fat, low-fiber diets promotes development of obesity and its associated consequences. Although genetics play an important role in dictating susceptibility to such obesogenic diets, mice with nearly uniform genetics exhibit marked heterogeneity in their extent of obesity in response to such diets. This suggests non-genetic determinants play a role in diet-induced obesity. Hence, we sought to identify parameters that predict, and/or correlate with, development of obesity in response to an obesogenic diet. We assayed behavior, metabolic parameters, inflammatory markers/cytokines, microbiota composition, and the fecal metaproteome, in a cohort of mice (<i>n</i> = 50) prior to, and the 8 weeks following, administration of an obesogenic high-fat low-fiber diet. Neither behavioral testing nor quantitation of inflammatory markers broadly predicted severity of diet-induced obesity. Although, the small subset of mice that exhibited basal elevations in serum IL-6 (<i>n</i> = 5) were among the more obese mice in the cohort. While fecal microbiota composition changed markedly in response to the obesogenic diet, it lacked the ability to predict which mice were relative prone or resistant to obesity. In contrast, fecal metaproteome analysis revealed functional and taxonomic differences among the proteins associated with proneness to obesity. Targeted interrogation of microbiota composition data successfully validated the taxonomic differences seen in the metaproteome. Although future work will be needed to determine the breadth of applicability of these associations to other cohorts of animals and humans, this study nonetheless highlights the potential power of gut microbial proteins to predict and perhaps impact development of obesity.
Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer’s Disease Risk (2018)

Abstract Apolipoprotein E (ApoE) mediates clearance of circulating lipoproteins from blood by binding to ApoE receptors. Humans express three genetic variants, ApoE2, ApoE3, and ApoE4, that exhibit distinct ApoE receptor binding properties. In brain, ApoE is abundantly produced by activated astrocytes and microglia, and three variants differentially affect Alzheimer’s disease (AD), such that ApoE2 protects against, and ApoE4 predisposes to the disease. A role for ApoE4 in driving microglial dysregulation and impeding Aβ clearance in AD is well documented, but the direct effects of three variants on neurons are poorly understood. Extending previous studies, we here demonstrate that ApoE variants differentially activate multiple neuronal signaling pathways and regulate synaptogenesis. Specifically, using human neurons cultured in the absence of glia to exclude indirect glial mechanisms, we show that ApoE broadly stimulates signal transduction cascades which among others enhance synapse formation with an ApoE4&gt;ApoE3&gt;ApoE2 potency rank order, paralleling the relative risk for AD conferred by these variants. Unlike the previously described induction of APP transcription, however, ApoE-induced synaptogenesis involves CREB rather than cFos activation. We thus propose that in brain, ApoE acts as a glia-secreted paracrine signal and activates neuronal signaling pathways in what may represent a protective response, with the differential potency of ApoE variants causing distinct levels of chronic signaling that may contribute to AD pathogenesis.
Cloud based Storage Drive Forensics (2016)

Cloud Storage is recently as emerging topic in these eras. As the data are increasing, the storage become major

issue for the people. There are different kind of Cloud Storage application such as One Drive, Sky Drive, Drop Box

and Google Drive. Google Drive is gaining more popularity as it is user friendly than any other Cloud Storage

Application. Google Drive is a Cloud Storage Application which allows user to store, share and edit the file in the

cloud. In these paper, the authors will perform forensics of Google Drive via di1fferent technique such as using

client software, Google Drive access via browser, Memory Analysis, Network Analysis and other techniques. From

that the Authors will find, what type of data remnants can be found in user device.
Silicon Microring Modulator for High SFDR Analog Links in Monolithic 45nm CMOS (2022)

We characterize the linearity of a lateral junction microring modulator in a mono-lithic 45 nm CMOS platform versus modulator bias, optical wavelength, and input power, and achieve peak third-order SFDR of <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="eq1" display="inline"> <mml:mrow> <mml:mn>96.4</mml:mn> <mml:mo/> <mml:mtext>dB</mml:mtext> <mml:mo>⋅</mml:mo> <mml:msup> <mml:mrow> <mml:mtext>Hz</mml:mtext> </mml:mrow> <mml:mrow> <mml:mfrac> <mml:mn>2</mml:mn> <mml:mn>3</mml:mn> </mml:mfrac> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> at 0dBm laser power.
Detection of equid herpesviruses among different Arabian horse populations in Egypt (2019)

Equid herpesviruses (EHVs) threaten equine health and can cause significant economic losses to the equine industry worldwide. Different equid herpesviruses, EHV-1, EHV-2, EHV-4 and EHV5 are regularly detected among horse populations. In Egypt, monitoring is sporadic but EHV-1 or EHV-4 have been reported to circulate in the horse population. However, there is a lack of reports related to infection and health status of horses, likely due to the absence of regular diagnostic procedures. In the current study, the circulation of four infectious equid herpesviruses (EHV-1, EHV-2, EHV-4 and EHV-5) among different Arabian horse populations and donkeys residing the same farm was monitored. Different samples were collected and DNA was extracted and subjected to quantitative (q)-PCR to detect the four equid herpesviruses using specific primers and probes. Antibody titres against EHV-1 and EHV-4 were tested using virus neutralization test and type-specific ELISA. The results showed that EHV-1, EHV-2, EHV-4 and EHV-5 are endemic and can be a continuous threat for horses in the absence of vaccination programs and frequent virus reactivation. There is an urgent need for introduction of active regular surveillance measures to investigate the presence of different equid herpesviruses, and other equine viral pathogens, in various horse populations around Egypt and to establish a standardized cataloguing of equine health status.
Sequence specific inhibition of human type II phospholipase A<sub>2</sub>, enzyme activity by phosphorothioate oligonucleotides (1994)

Phosphorothioate oligonucleotides were identified which directly inhibited human type II phospholipase A2 (PLA2) enzyme activity in a sequence specific manner. The minimum pharmacophore common to all oligonucleotides which inhibited PLA2 enzyme activity consisted of two sets of three or more consecutive guanosine residues in a row. These oligonucleotides appear to form G quartets resulting in the formation of oligonucleotide aggregates. Additionally, a phosphorothioate backbone was required to be effective inhibitors of type II PLA2. The activity of one oligodeoxynucleotide, IP 3196 (5'-GGGTGGGTATAGAAGGGCTCC-3') has been characterized in more detail. IP 3196 inhibited PLA2 enzyme activity when the substrate was presented in the form of a phospholipid bilayer but not when presented in the form of a mixed micelle with anionic detergents. Human type II PLA2 was 50-fold more sensitive to inhibition by IP 3196 than venom and pancreatic type I enzymes. These data demonstrate that phosphorothioate oligonucleotides can specifically inhibit human type II PLA2 enzyme activity in a sequence specific manner.
Severity of Tip-Out Induced Impacts in Drive Line Systems With Backlash (2010)

Numerical simulations are used to study the transient behavior of a four degree-of-freedom, rotational piecewise linear system. This study focuses on the impact between bodies in a system with backlash as a result of a sudden step input and the associated transient response. The subsequent single sided impacts and double sided impacts are studied as a function of the amplitude of the step input and the size of the backlash. Transitions have been observed between double sided impact regions and single sided impact regions, which agree with earlier findings. However, in this paper a more complete overview of the boundaries is given. The severity of the impacts is quantified with the peak-to-peak acceleration of the impacting bodies. The increase in the size of step input increases the severity of the impacts. However, the increase in backlash size leads to an extremum in impact severity. This is a possible explanation for seeming contradictions in literature.
Effects of SNF472, a Novel Inhibitor of Hydroxyapatite Crystallization in Patients Receiving Hemodialysis — Subgroup Analyses of the CALIPSO Trial (2020)

SNF472 treatment for 52 weeks reduced CACvs progression compared with placebo in a broad range of patients receiving maintenance hemodialysis. Future studies will determine the impact of SNF472 on cardiovascular events in this population.
Nonlinear Equalizer for Multi-User Hybrid mmW Massive MIMO Systems (2017)

The aim of this manuscript is to propose a new hybrid nonlinear block space-time receiver structure for millimeter wave (mmW) systems, to efficiently separate the spatial streams. We consider a fully connected analog-digital architecture. We assume that both the transmitter and the receiver are equipped with a large antenna array and the number of radio frequency (RF) chains is lower than the number of antennas. The analog and digital parts of the equalizer are jointly optimized using as a metric the mean square error (MSE) between the transmitted data vector and its estimate after the digital equalizer. The specificities of the analog domain impose several constraints in the joint optimization. To efficiently deal with the constraints the analog part is selected from a dic-tionary based on the array response vectors. The performance results have shown that the performance of our hybrid nonlinear space-time equalizer is close to the fully digital counterpart after only a few iterations. Moreover, it clearly outperforms the linear receivers recently proposed for hybrid mmW massive MIMO architectures.
Experiment K-7-33: Functional Neuromuscular Adaptation to Spaceflight (1994)

The following data were collected from two Rhesus monkeys (782 and 2483) that were flown aboard a 14-day biosatellite mission (COSMOS 2044). The proposed study was designed to determine the effects of the absence of weight support on flexor and extensor muscles of the hindlimb. These effects were assessed morphologically and biochemically from muscle biopsies taken from a slow extensor, the soleus; a fast extensor, the medial gastrocnemius; and a fast flexor, the tibialis anterior. A second objective of this study was to determine the relative importance of activity (as determined by intramuscular electromyography, and force (as determined by joint torque) on the adaptation of muscle.
J Wave Syndromes as a Cause of Sudden Arrhythmic Death (2013)

Accentuated J waves have been associated with idiopathic ventricular tachycardia and fibrillation (VT/VF) for nearly three decades. Prominent J waves characterize both Brugada and early repolarization syndromes leading to their designation as J wave syndromes. An early repolarization (ER) pattern, characterized by J point elevation, slurring of the terminal part of the QRS and ST segment elevation was considered to be a totally benign electrocardiographic manifestation until a decade ago. Recent casecontrol and population-based association studies have advanced evidence that an ER pattern in the inferior or infero-lateral leads is associated with increased risk for life-threatening arrhythmias, named early repolarization syndrome (ERS). ERS and Brugada syndrome (BrS) share similar electrocardiogram features, clinical outcomes, risk factors as well as a common arrhythmic platform related to amplification of Ito-mediated J waves. Although BrS and ERS differ with respect to the magnitude and lead location of abnormal J wave manifestation, they are thought to represent a continuous spectrum of phenotypic expression, termed J wave syndromes. A classification scheme for ERS has been proposed: type 1, displaying an ER pattern predominantly in the lateral precordial leads, is considered to be largely benign; type 2, displaying an ER pattern predominantly in inferior or infero-lateral leads, is associated with a higher level of risk; whereas type 3, displaying an ER pattern globally in inferior, lateral and right precordial leads, is associated with the highest level of risk for development of malignant arrhythmias and is often associated with VF storms.
Comparative study of stochastic optimization methods to solve load allocation problem for aircraft electrical power system design (2012)

International audience
Commonality of Drug-associated Adverse Events Detected by 4 Commonly Used Data Mining Algorithms (2014)

The EBGM method was the most conservative among the 4 methods examined, which suggested its better suitability for pharmacoepidemiological studies. Further examinations should be performed on the reproducibility of clinical observations, especially for EBGM-based signals.
The Efficacy of Mesenchymal Stem Cell Transplantation in Caustic Esophagus Injury: An Experimental Study (2014)

Introduction. Ingestion of corrosive substances may lead to stricture formation in esophagus as a late complication. Full thickness injury seems to exterminate tissue stem cells of esophagus. Mesenchymal stem cells (MSCs) can differentiate into specific cell lineages and have the capacity of homing in sites of injury. Aim and Methods. We aimed to investigate the efficacy of MSC transplantation, on prevention of esophageal damage and stricture formation after caustic esophagus injury in rats. 54 rats were allocated into four groups; 4 rats were sacrificed for MSC production. Group 1, untreated controls (n: 10). Group 2, membrane labeled MSCs-treated rats (n: 20). Group 3, biodistribution of fluorodeoxyglucose labeled MSCs via positron emission tomography (PET) imaging (n: 10). Group 4, sham operated (n: 10). Standard caustic esophageal burns were created and MSCs were transplanted 24 hours after. All rats were sacrificed at the 21st days. Results. PET scan images revealed the homing behavior of MSCs to the injury site. The histopathology damage score was not significantly different from controls. However, we demonstrated Dil labeled epithelial and muscle cells which were originating from transplanted MSCs. Conclusion. MSC transplantation after caustic esophageal injury may be a helpful treatment modality; however, probably repeated infusions are needed.
High performance circularly polarized microstrip array antenna at Ka band (1992)

The experimental research, design, and testing of a high-performance circularly polarized microstrip array antenna operating at Ka band are described. A simple and robust design of a 16-element circularly polarized microstrip array is presented. It utilizes four newly invented high-performance circularly polarized microstrip array antenna clusters. The antenna elements used are square microstrips, although a circular one will do as well. A single probe feed excites the 16-element array and the center frequency of this design is chosen to be 29.5 GHz. The array was designed on a 10-mil low-loss duroid substrate. Return loss measurements obtained from a sample array are shown, and the antenna gain pattern is presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Nanolithography of chemically prepared Si with a scanning tunneling microscope (1991)

Permanent nanometer structures were fabricated on chemically prepared Si by chemical activation of loosely bound hydrocarbon clusters triggered by voltage pulses across the tunneling gap of a scanning tunneling microscope. Current-voltage measurements show that the fabrication process results in a local transition from a Schottky junction behavior to a MIS junction behavior, indicating the formation of topographic structures. Our experimental results indicate that the size and density of the clusters and the shape of the tunneling tip are important factors of the process. An example of parallel fabrication is presented.
An SQNR Improvement Technique Based on Magnitude Segmentation for Polar Quantizers (2014)

This paper improves the performance of the polar quantizer for wireless signals with complex Gaussian probability density functions (PDFs) first proposed by Nazari et al. A new signal-to-quantization noise ratio (SQNR) enhancement technique based on magnitude segmentation of polar space is employed, which can boost the SQNR of the quantizer significantly compared to that of the conventional rectangular and polar quantizers. First, an N-segmentation technique is examined using N different bit allocations for magnitude and phase quantizers. The study then covers a polar quantizer incorporating a three-segmentation technique for practical implementation. Using this technique, the overall maximum SQNR of the polar quantizer improves about 2.5 dB higher than the rectangular quantizer. In addition, over 14 dB SQNR improvement at low average magnitude is achieved if equal numbers of quantization levels for both polar and rectangular quantizers are utilized.
ChemInform Abstract: Two New Bisdesmosidic Steroidal Saponins from the Underground Parts of Ruscus aculeatus. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Active Site Inhibitors of HCV NS5B Polymerase. The Development and Pharmacophore of 2‐Thienyl‐5,6‐dihydroxypyrimidine‐4‐carboxylic Acid. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Characterization of transgenic mice lineages. II. Transgenic mice expressing HBsAg particles and showing female sterility (1993)

Abstract The tissue specificity of the expression of the hepatitis B surface antigen (HBsAg) in transgenic mice was studied. Northern blot hybridization and electron microscopy of various tissues revealed the higher HBsAg transcription levels confined to the liver and kidney, and to a lesser extent to the spleen and intestines. In electron microscopic studies we found HBsAg particles in the serum of transgenic animals to be positive by ELISA to HBsAg. The expression of the transgene was localized in situ in the ovary, liver, kidney, and spleen of transgenic mice, employing a polyclonal antiserum directed against the HBsAg and conjugated with protein A‐gold. Surprisingly, F1 transgenic females from the CB‐104 line, expressing HBsAg in the serum, showed impaired fertility, although the ovarian function was not diminished. Normal off‐spring were obtained after cross embryo transfer between transgenic (Tg) females to non‐transgenic (Ntg) recipients or from Ntg embryos transferred to Tg recipients. We speculate that this phenomenon could be related to a disruption on a gene(s) somehow involved in the reproductive performance of the transgenic females.
Effect of the Time Delay between Spin State Preparation and Measurement on Electron Spin Teleportation in a Covalent Donor–Acceptor–Radical System (2021)

We recently demonstrated photodriven quantum teleportation of an electron spin state in a covalent donor-acceptor-radical (D-A-R<sup>•</sup>) system. Following specific spin state preparation on R<sup>•</sup> with a microwave pulse, photoexcitation of A results in two-step electron transfer producing D<sup>•+</sup>-A-R<sup>-</sup>, where the spin state on R<sup>•</sup> is teleported to D<sup>•+</sup>. This study examines the effects of varying the time (τ<sub>D</sub>) between spin state preparation and photoinitiated teleportation. Using pulse electron paramagnetic resonance spectroscopy, the spin echo of D<sup>•+</sup> resulting from teleportation shows a damped oscillation as a function of τ<sub>D</sub> that is simulated using a density matrix model, which provides a fundamental understanding of the echo behavior. Teleportation fidelity calculations also show oscillatory behavior as a function of τ<sub>D</sub> due to the accumulation of a phase factor between ⟨S<sub><i>x</i></sub>⟩ and ⟨S<sub><i>y</i></sub>⟩. Understanding experimental parameters intrinsic to quantum teleportation in molecular systems is crucial to leveraging this phenomenon for quantum information applications.