gebhart/patrepeval huggingface dataset:
The detection of encapsulated and non-encapsulated species of<i>Trichinella</i>suggests the existence of two evolutive lines in the genus (2001)

In recent years, the discovery of many non-encapsulated isolates of Trichinella, designated Trichinella pseudospiralis and the identification of a new non-encapsulated species, Trichinella papuae, has revealed that the biomass of the genus Trichinella does not only include the well known encapsulated species (T. spiralis, T. nativa, T. britovi, T. murrelli, and T. nelsoni) but also includes geographically disseminated, non-encapsulated species that represent important biological entities in the genus. Larvae of the first stage (L1) of both non-encapsulated and encapsulated species are able to penetrate the muscle cell and induce a dedifferentiation of this cell. But following this point in the parenteral cycle, non-encapsulated and encapsulated species diverge with respect to their developmental strategies where L1 of encapsulated species are able to induce the nurse cell to synthesize collagen, unlike non-encapsulated larvae which do not induce collagen production. The presence or absence of a collagen capsule is of great importance in the natural cycle of these parasites in that it allows the encapsulated larva to survive to substantially longer periods of time and therefore remain infective even within putrified muscle tissue.
Monolithic Integration of All‐in‐One Supercapacitor for 3D Electronics (2019)

Abstract A supercapacitor is usually stacked in the configuration of a layered sandwiched architecture, and has been adopted as discrete energy storage device or circuit component. However, this stacked structure decreases mechanical integrity, leads to low specific capacity, and prevents high‐density monolithic integration. Here all‐in‐one supercapacitors are fabricated by integrating cathode, anode, current collector, and separator into one monolithic glass fiber (GF) substrate together with other circuit components through matured and scalable fabrication techniques, the all‐in‐one supercapacitor is embedded as a component for 3D electronics. This all‐in‐one architecture demonstrates its effectiveness in the prevention of the delamination of the sandwiched supercapacitor and the minimization of the proportion of inactive materials. The supercapacitor delivers high power density (320 mW cm −3 ) and energy density (2.12 mWh cm −3 ), and exhibits a capacitance retention of 100% even after a continuous cycling of 431 h. Furthermore, a 3D polydimethylsiloxane/GF architecture is constructed for driving a flash light emitting diode system, where the all‐in‐one supercapacitor is monolithically integrated in the 3D system, and each layer is connected via vertical through‐holes. This all‐in‐one device can be constructed with a macroscopically available membrane and readily integrated into 3D systems without secondary packaging, providing the potential for high‐density heterogeneous 3D electronics.
Evidence for dynamic heterogeneities in computer simulations of miscible polymer blends (2003)

The controversial origins of the unusual dynamics of miscible polymer blends are incisively probed through computer simulations. The distribution of mobilities experienced by a probe monomer in a miscible blend of chains with disparate glass transition temperatures is found to be much broader than in the pure polymers, providing clear evidence for local concentration variations in the mixture. These concentration fluctuations yield distinctly different temperature dependences for the dynamics of the two different components, in a manner that closely mimics experiments.
Thioether‐Functionalized Corn Oil Biosorbents for the Removal of Mercury and Silver Ions from Aqueous Solutions (2018)

Abstract Heavy‐metal contamination is one of the most important environmental problems faced in the world, particularly in developing countries. Metals such as silver and mercury from drinking water, food, and air sources can accumulate in living organisms and present significant health concerns. Meanwhile, the demand for these metals in many industries continues to increase. In the present study, thioether‐functionalized corn oil (TFCO) from a photoinitiated thiol‐ene synthesis was utilized to remove Ag + and Hg 2+ ions from an aqueous solution. An aqueous solution containing AgNO 3 and Hg[NO 3 ] 2 was prepared and contacted directly with TFCO. After vortex mixing for 60 s, the experiment ran for 351 min with the aqueous phase being periodically sampled for the analysis of metal ions (M n + ). Results showed that 88.9% of Ag + and 99.6% of Hg 2+ ions were removed from the aqueous phase by the TFCO. Mass balances indicated that the total M n + concentration in the oil phase was 13.890 g kg −1 under the conditions studied. TFCO exhibited higher selectivity for removing Hg 2+ than for Ag + ions. Analysis of the adsorption kinetics showed that a pseudosecond‐order model may be used to determine the rate of Ag + ion sorption by the oil phase. The presence of the Hg 2+ ions interfered with the adsorption of Ag + ions from the aqueous solution.
A unique single-step algorithm for time-stepping electromagnetic fields (1993)

A unique algorithm for time-stepping electromagnetic fields is developed that saves a significant amount of computer resources. It is applied to two-dimensional scattering problems and can be applied to any type of grid and finite difference scheme that uses the Yee time-stepping algorithm. The two-step finite difference equations are reduced to a single step which bypasses many redundant calculations. CPU and memory savings are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Aminophenyl‐ and Nitrophenyl‐Labeled Nucleoside Triphosphates: Synthesis, Enzymatic Incorporation, and Electrochemical Detection (2008)

Primer extension is used to incorporate labeled nucleoside triphosphates into oligonucleotides (ONs). Aminophenyl and nitrophenyl modifications serve as electrochemical labels that are detectable by either oxidation or reduction, respectively (see representation of the ON double strand and redox curves). The redox potentials of the labels differ depending on the nucleobase and respond to incorporation into ONs. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705088_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A Mild and Regioselective Route to Functionalized Quinazolines (2015)

A Rh-catalyzed ortho-amidation cyclocondensation sequence gave a range of 4-aminoquinazolines in high yield. The method features a remarkably mild C(sp(2) )H activation step and can be exploited to rapidly access compounds with established biological activity.
Association between<i>CDH1</i>haplotypes and gastric cancer risk in a Japanese population (2007)

These results suggest that the ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of GC in the Japanese population.
Mushroom Tyrosinase-Based Enzyme Inhibition Assays Are Not Suitable for Bioactivity-Guided Fractionation of Extracts (2019)

Tyrosinase (Tyr) catalyzes the rate-limiting step of melanogenesis in human skin and is thus the main target for treating pigmentation disorders today. This has led to an increased research interest in Tyr inhibitors during the last decades, with a frequent focus on polyphenols. In the early stages of drug discovery, it is typical to avoid the high costs of human Tyr by using the more economic mushroom tyrosinase (mh-Tyr). Since some polyphenols are accepted as substrates by mh-Tyr, the present study aimed to more generally investigate this enzyme's specificity toward polyphenols and to discuss its significance in the context of bioactivity-guided fractionation. Mh-Tyr substrates can change the sample color during an inhibition assay, leading to unreliable inhibition constants or to the discontinuation of a bioactivity-guided fractionation campaign. A data set of 56 natural products was investigated and classified into assay interferers (AIs) and noninterferers, using a spectrophotometric and an LC-ESIHRMS assay. Based on these experimental findings, structure-activity relationships defining AIs were deduced and implemented into an in silico tool that will allow for rapid prescreening in the future. We anticipate that these results will aid in the search for new Tyr inhibitors and contribute to the understanding of this enzyme, as well as its optimal use in pharmacological research.
Breeding Record for Rufous-Crowned Emu-wren (2011)

On 30th March 2010 we observed a nest of the Rufous-crowned Emu-wren Stipiturus ruficeps near Mt. Unbunmaroo, otherwise known as Black Mountain, 54 km north-east of Boulia in western Queensland. Th...
Monoclonal antibodies to growth hormone (GH) prolong liver GH binding and GH-induced IGF-I/IGFBP-3 synthesis (1999)

This time-course study further explored the mechanisms whereby monoclonal antibodies (MAbs) may enhance growth hormone (GH) effects. Hypophysectomized rats were killed 0, 1, 3, 6, 12, 24, and 48 h after a single injection of bovine (b) GH alone or complexed with an anti-bGH MAb. Serum insulin-like growth factor I (IGF-I) concentrations were increased more and for a longer period after MAb-GH complexes (peak at 24 h: 295 +/- 24 ng/ml) than after bGH alone (peak at 12 h: 219 +/- 37 ng/ml; P < 0.01), whereas liver IGF-I mRNA was similar at 12 h in both groups but remained higher at 24 h (by 65%, P < 0.001) and 48 h (by 64%, P < 0.001) in the presence of the MAb. Induction of serum insulin-like growth factor-binding protein (IGFBP)-3 and liver IGFBP-3 mRNA by bGH also was markedly amplified by the MAb (3.6- and 2-fold at 24 h, respectively; P < 0.01). GH receptors (GHR) remained occupied for a longer period after MAb-GH injection (36 +/- 16 and 35 +/- 8% at 6 and 12 h, respectively) compared with bGH alone (0 +/- 28 and -15 +/- 11%), whereas total liver GH-binding sites and GHR mRNA levels were not affected by the MAb. We conclude that MAbs against GH amplify and prolong the serum IGF-I response to GH, which may result from both a prolongation of liver IGF-I synthesis and an enhanced induction of IGFBP-3. These two effects may in turn be the consequences of sustained GH binding to its liver receptors in the presence of MAb.
Supplementary Figure 2, Part 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies (2023)

Supplementary Figure 2, Part 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies
ChemInform Abstract: Stereoselective Synthesis of Conformationally Constrained Reverse Turn Dipeptide Mimetics (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Anti-nociceptive effect of tricyclic anti-depressants following intrathecal administration. (1985)

The anti-nociceptive effects of three tricyclic anti-depressants (desipramine, protriptyline, fluoxetine) were evaluated in mice following intrathecal administration. Nociceptive behavior was produced by intrathecal administration of Substance P and measured for 60 seconds following subcutaneous and intrathecal administration of vehicle and increasing doses of the drugs being tested. Systemically administered protriptyline produced dose related antinociception in this paradigm. A similar effect was seen following systemic desipramine; while fluoxetine was inactive systemically. Both protriptyline and desipramine given intrathecally were antinociceptive while fluoxetine had a biphasic effect, being analgesic only at low doses. These results indicate that tricyclic antidepressants may produce analgesia at the spinal level in rodents. This action may be related to the therapeutic success of tricyclic antidepressants in chronic pain syndromes.
ChemInform Abstract: Acetogenic Isoquinoline Alkaloids. Part 77. Ancistroheynine A, the First 7,8′‐Coupled Naphthylisoquinoline Alkaloid from Ancistrocladus heyneanus. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Chimie, nanomatériaux, nanotechnologies (2020)

On rencontre les nanotechnologies partout : dans nos smartphones, les nouveaux médicaments, l’alimentation ou les cosmétiques, dans les nouveaux matériaux pour le bâtiment, l’automobile ou l’énergie… Ils intriguent, ils inquiètent, ils enthousiasment, mais que sont-ils ? Cet ouvrage reprend les exposés d’experts de l’industrie et des laboratoires qui font comprendre les propriétés étonnantes et prometteuses des nanomatériaux. Le thème coordinateur de ces exposés est l’utilisation de la chimie dans tous ses aspects – organique ou supramoléculaire pour la nanomédecine, inorganique ou polymère pour la nanoélectronique –, sa puissance d’innovation et son rôle clé pour mettre à notre disposition cette spectaculaire richesse de propriétés. Les questions sur la sécurité des nanomatériaux ne sont pas absentes : on voit le soin qui est déployé dans les laboratoires pour qu’ils soient caractérisés et pour mesurer les risques potentiels évalués. L’ambigüité première (les nanomatériaux sont-ils utiles ? Ou dangereux ?) nous confronte à nous-mêmes : sommes-nous pour le progrès ? Ou sommes-nous en face d’innovations au simple but de développer la consommation ? De quoi apprendre le nouveau monde technologique et réfléchir !
A phase II trial cohort of nivolumab plus ipilimumab in patients (Pts) with recurrent/metastatic adenoid cystic carcinoma (R/M ACC). (2019)

6084 Background: R/M ACC is a malignant neoplasm most commonly of salivary gland origin with no standard treatment. The impact of combined PD-1/CTLA-4 checkpoint blockade in R/M ACC is unknown. Methods: In a two-stage minimax phase II trial, pts with progressive R/M ACC (non-salivary primaries allowed) were enrolled and treated with nivolumab 3 mg/kg every 2 weeks plus ipilimumab 1 mg/kg every 6 weeks (1 cycle = 6 weeks). Imaging, using RECIST v1.1 response assessment, was scheduled to be performed approximately every 12 weeks. The primary endpoint was overall response rate (ORR = complete response [CR]+partial response [PR]) per RECIST v1.1. To detect a difference between an unacceptable ORR of 5% and a desirable ORR of 20% (one-sided type I error of 10%, power of 90%), at least 1 in the first 18 pts required an observed response. At least 4 responses of 32 total pts were needed to meet the primary endpoint. Treatment beyond progression of disease (PD) was allowed at the discretion of the investigator. A second cohort of pts with non-ACC salivary cancer is still accruing for separate analysis. Results: From 6/12/2017-6/20/2018, 32 pts were enrolled and evaluable for the primary endpoint. There was 1 confirmed PR in the first 18 pts, therefore enrollment of the second stage continued. ORR was 6% (2/32). One additional pt had an unconfirmed PR (-31% regression before CNS PD). For best overall response, there were 2 PRs, 15 SD, and 11 PD. Four pts never reached a first disease assessment: 3 due to death from clinical PD and 1 was removed for toxicity. Six pts discontinued the trial for toxicities (Grade 4 (G4) neutropenia/sepsis and G3 adrenal insufficiency (1), G2 hypophysitis (2), G3 arthritis &gt; 7 days (1), G3 colitis (1), and G3 hepatitis/G4 creatinine kinase (CK) elevation (1)). The 2 confirmed PRs consisted of -73.1% and -58.4% regressions, with a duration of therapy of 18.4 and 7.8 months, respectively (treatment ongoing for both). Conclusions: The study did not meet its primary endpoint, though the responses observed were dramatic. Paired biopsy and peripheral blood samples will be analyzed to elucidate insights into mechanisms of response and resistance to dual checkpoint blockade. Clinical trial information: NCT03172624.
Magnetic Microtweezers: A Tool for High‐Throughput Bioseparation in Sub‐Nanoliter Droplets (2022)

Abstract Droplet microfluidics has revolutionized the field of single‐cell analysis. Production of micro‐droplets at high throughput allows for rapid isolation of single cells within micro‐compartments, which are then subjected to different analytical processes. However, certain operations, such as physical separation from droplets, remain difficult to implement at high throughput and single‐cell level but would be highly valuable to currently expanding multiomics techniques, where several biomolecular modalities are involved. This work presents a method based on microfabricated NiFe structures, the magnetic microtweezers, to trap and extract magnetic particles from a continuous stream of sub‐nanoliter droplets, and enable physical separation from single cell‐based droplets. Using a physical model, simulations, and experiments, a comprehensive description of the complex particle extraction process is provided. After optimization, the magnetic microtweezers provided unprecedented particle extraction performance, allowing extraction of high loads (10‐20 ng) of magnetic particles from 500 pL droplets, with a capture rate close to 100% at 20 Hz. To evaluate the applicability to single‐cell analysis, mRNA extraction is performed. It demonstrated around 72% specific recovery of mRNA from droplets containing purified nucleic acids, and 43% from single cells. Overall, this approach enables efficient physical separation that is compatible with existing high‐throughput droplet‐based single‐cell workflows.
A review of the use of risk factor modification in the management of atherosclerotic arterial disease (2005)

Based on current knowledge, it appears that atherosclerosis is a multifactorial disease. There are differences in the effects of atherosclerotic risk factors between the various vascular beds. More than one risk factor is found in the majority of the patients and, often there is atherosclerotic involvement of several vascular territories. In order to prevent or retard atherosclerotic complications and improve patient survival, it is prudent that all the major modifiable risk factors should be corrected in patients with cardiovascular, cerebrovascular, and peripheral vascular disease.
Growing Evidence Supports the Use of Radiation Therapy in Unresectable Intrahepatic Cholangiocarcinoma (2016)

From the Department of Radiation Oncology, University of Michigan Medical Center, Ann Arbor, MI. Conflicts of Interest and Sources of Funding: The authors have disclosed that they have no significant relationships with, or financial interest in, any commercial companies pertaining to this article. Reprints: Kyle C. Cuneo, MD, University of Michigan Medical School, Ann Arbor. E-mail: [email protected].
ChemInform Abstract: Dirubidium Tetrachlorodioxouranium(VI)‐Water (1:2). (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nonmetallic left-handed material based on negative-positive anisotropy in low-dimensional quantum structures (2008)

Nonmetallic left-handed material by assembly of low-dimensional quantum structures is theoretically proposed. Specifically, we predict relatively wideband, tunable left-handed material by employing structures comprised of semiconductor quantum wells and quantum dots. Well established epitaxial growth of semiconductor material allows a feasible composition of such metamaterials. The advantages of the proposed scheme is the potential ability to invert the material losses to gain by electrical pumping and the possibility to switch the material regime from left-handed to right-handed by applying external voltage, which are not affordable in the recently proposed left-handed material configurations.
14nm FDSOI technology for high speed and energy efficient applications (2014)

This paper presents a 14nm technology designed for high speed and energy efficient applications using strain-engineered FDSOI transistors. Compared to the 28nm FDSOI technology, this 14nm FDSOI technology provides 0.55× area scaling and delivers a 30% speed boost at the same power, or a 55% power reduction at the same speed, due to an increase in drive current and low gate-to-drain capacitance. Using forward back bias (FBB) we experimentally demonstrate that the power efficiency of this technology provides an additional 40% dynamic power reduction for ring oscillators working at the same speed. Finally, a full single-port SRAM offering is reported, including an 0.081°m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> high-density bitcell and two 0.090°m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> bitcell flavors used to address high performance and low leakage-low Vmin requirements.
Protective effects of the lipophilic redox conjugate tocopheryl succinyl‐ethyl ferulate on HIV replication (1997)

Previously, we demonstrated that ferulate ethyl and tocopherol reduced HIV replication. In this study, we investigate whether the conjugation of both compounds (O-tocopheryl succinyl O-ethyl ferulate) can increase HIV inhibition. We show here for the first time that O-tocopheryl succinyl O-ethyl ferulate inhibits 80% of HIV replication (HIV-1 acute infection and HIV transmission), inhibits cell lipoperoxidation and prevents cellular glutathione consumption. Compared to ferulate ethyl and tocopheryl succinyl, O-tocopheryl succinyl O-ethyl ferulate inhibits more HIV replication. This may be due in part to the great increase in the lipophilicity of this compound.
Pinned to the walls: impact of packaging and application properties on the memory and power walls (2011)

This article presents a study of the impact of packaging on the memory and power walls, in the context of application properties. The analysis is supported by characterizations of 130 hardware designs spanning 30 years, along with both microarchitectural simulation and actual-hardware performance counter measurements of 25 applications. It is shown that if trends in supply pin count (growing as the square root of current) and total packaging pin count (doubling every six years) continue, application memory bandwidth requirements, even in the presence of aggressive cache hierarchies, may limit the number of on-chip threads to under a thousand in 2020.