gebhart/patrepeval huggingface dataset:
PROLONGATION OF GRAFT SURVIVAL IN PRIMATE ALLOGRAFT TRANSPLANTATION BY YTTRIUM-90-LABELED ANTI-TAC IN CONJUNCTION WITH GRANULOCYTE COLONY-STIMULATING FACTOR (1992)

High-affinity IL-2 receptors are expressed by T cells activated in response to foreign histocompatibility antigens but not by normal resting T cells. To exploit this difference in IL-2R expression, anti-Tac, a murine monoclonal antibody specific for the IL-2R alpha subunit, was used to inhibit organ allograft rejection. To enhance its effector function, anti-Tac was armed by chelation with yttrium-90, a pure beta-emitting radionuclide. Animals received no immunosuppression (n = 5, group I, controls), unmodified anti-Tac (n = 5, 1 mg/kg q.o.d., group II), or 90Y-anti-Tac (n = 5, 1.6 mCi/kg divided into four doses, group III). The animals in group IV (n = 4) were treated identically to those in group III with the exception that 5 micrograms/kg/dose of granulocyte colony-stimulating factor was administered intramuscularly on the days when the yttrium-90 was given and on postoperative days 12 through 35 in order to reduce hematopoietic toxicity. Mean graft survival +/- S.E.M. for the control group was 8.2 +/- 0.5 days as compared with 13.8 +/- 2.1 days (P < 0.05) for those monkeys treated with unmodified anti-Tac. Graft survival was further prolonged in animals of group III that received 90Y-anti-Tac, with a mean graft survival of 45.0 +/- 11.8 days; however, three of the five monkeys retained viable grafts within this group but died secondary to bone marrow suppression. In comparison, the monkeys in group IV that were treated with G-CSF in conjunction with 90Y-anti-Tac had a mean graft survival of 49.2 +/- 2.9 days. In contrast to group III there were no deaths in the group (IV) receiving G-CSF. Furthermore, animals in group IV had a reduced magnitude and shortened duration of irradiation-induced neutropenia when compared with that observed in group III animals that did not receive G-CSF. Thus, treatment with 90Y-anti-Tac in conjunction with G-CSF may have potential applications in organ transplantation and the treatment of IL-2 receptor-expressing neoplastic diseases.
AN ETCH HOLE-FREE PROCESS FOR TEMPERATURE-COMPENSATED, HIGH Q, ENCAPSULATED RESONATORS (2014)

A process is presented for the fabrication of high quality factor (Q), temperature-compensated silicon resonators without release-etch perforations within the epitaxial polysilicon encapsulation (epi-seal). Electrostatically actuated Lam-mode square resonators up to 400 m wide with frequencies from 8 to 107 MHz are released with no etch perforations, resulting in high f-Q products of up to 2e13 Hz. Temperature compensation with a turnover point is achieved using an epitaxially grown, highly boron-doped device layer.
Dopamine-Dependent Long-Term Depression at Subthalamo-Nigral Synapses Is Lost in Experimental Parkinsonism (2013)

Impairments of synaptic plasticity are a hallmark of several neurological disorders, including Parkinson's disease (PD) which results from the progressive loss of dopaminergic neurons of the substantia nigra pars compacta leading to abnormal activity within the basal ganglia (BG) network and pathological motor symptoms. Indeed, disrupted plasticity at corticostriatal glutamatergic synapses, the gateway of the BG, is correlated to the onset of PD-related movement disorders and thus has been proposed to be a key neural substrate regulating information flow and motor function in BG circuits. However, a critical question is whether similar plasticity impairments could occur at other glutamatergic connections within the BG that would also affect the inhibitory influence of the network on the motor thalamus. Here, we show that long-term plasticity at subthalamo-nigral glutamatergic synapses (STN-SNr) sculpting the activity patterns of nigral neurons, the main output of the network, is also affected in experimental parkinsonism. Using whole-cell patch-clamp in acute rat brain slices, we describe a molecular pathway supporting an activity-dependent long-term depression of STN-SNr synapses through an NMDAR-and D1/5 dopamine receptor-mediated endocytosis of synaptic AMPA glutamate receptors. We also show that this plastic property is lost in an experimental rat model of PD but can be restored through the recruitment of dopamine D1/5 receptors. Altogether, our findings suggest that pathological impairments of subthalamo-nigral plasticity may enhance BG outputs and thereby contribute to PD-related motor dysfunctions.
Learning from Longitudinal Face Demonstration - Where Tractable Deep\n Modeling Meets Inverse Reinforcement Learning (2017)

This paper presents a novel Subject-dependent Deep Aging Path (SDAP), which\ninherits the merits of both Generative Probabilistic Modeling and Inverse\nReinforcement Learning to model the facial structures and the longitudinal face\naging process of a given subject. The proposed SDAP is optimized using\ntractable log-likelihood objective functions with Convolutional Neural Networks\n(CNNs) based deep feature extraction. Instead of applying a fixed aging\ndevelopment path for all input faces and subjects, SDAP is able to provide the\nmost appropriate aging development path for individual subject that optimizes\nthe reward aging formulation. Unlike previous methods that can take only one\nimage as the input, SDAP further allows multiple images as inputs, i.e. all\ninformation of a subject at either the same or different ages, to produce the\noptimal aging path for the given subject. Finally, SDAP allows efficiently\nsynthesizing in-the-wild aging faces. The proposed model is experimented in\nboth tasks of face aging synthesis and cross-age face verification. The\nexperimental results consistently show SDAP achieves the state-of-the-art\nperformance on numerous face aging databases, i.e. FG-NET, MORPH, AginG Faces\nin the Wild (AGFW), and Cross-Age Celebrity Dataset (CACD). Furthermore, we\nalso evaluate the performance of SDAP on large-scale Megaface challenge to\ndemonstrate the advantages of the proposed solution.\n
Inflow mapping method for numerical flow simulations of OCT-based patient-specific vessels using CFD (2017)

Abstract Alteration of the flow characteristics in coronary vessels is correlated with coronary heart disease (CHD). In particular, wall shear stress (WSS) appears to be a hemody-namic key factor in the genesis of CHD. Since computational fluid dynamics (CFD) is a well-known method for the inves-tigation of WSS, it may be a valuable tool for the prediction of CHD. Latest imaging techniques, such as optical coher-ence tomography (OCT) in conjunction with angiography deliver precise 2D data sets of patient-specific vessel geome-try, which can be used for CFD analysis. Current CFD stud-ies utilize patient-specific geometries, but are lacking well defined physiologic inflow conditions. In this study, we present an inflow mapping method for patient-specific arterial vessels, which is capable of consider-ing the influence of bifurcations located proximal of the OCT-data set. At first, the patient-specific vessel was recon-structed. For this purpose the OCT-based vessel cross sec-tions were arranged along an angiographic based vessel pathway. Secondly, we simulated the flow field in a generic bifurcation model by means of CFD. Thereafter the flow field of a side branch was extracted and transferred (mapped) to the inlet of the patient-specific vessel. To evaluate the influence of the physiological inlet the WSS distribution of the same patient-specific vessel was calculated using an axial-symmetric inflow condition. Analy-sis of the simulation data yielded deviations of the WSS distribution in the proximal vessel segment. A bifurcation, located upstream of the relevant vessel segment strongly affects the flow in the OCT-based vessel reconstruction and has a strong influence on the results of the numerical analy-sis. Therefore, it is important to implement not only the pa-tient-specific geometry, but also an inlet boundary condition adapted to the upstream velocity distribution reflecting the actual proximal flow situation of the vessel.
Different cytokine expression profiles in metaphyseal and diaphyseal fracture healing may provide new insights in the field of bone regeneration (2022)

Introduction Fractures are traumatic injuries that mainly occur in bone metaphysis, however most studies of bone healing have focused on diaphyseal bone.This is important because the healing process of trabecular metaphyseal bone has different healing characteristics from the diaphyseal area.Inflammation is thought to play an important, but different role in these two bone fracture types: diaphyseal fractures heal slowly through the formation of callus tissue, and metaphyseal trabecular bone heals faster, with no, or limited callus formation.As cytokines are key modulators of inflammation, the aim of the present study was to define the cytokine profiles at the core of these two conditions with possible implications for the bone healing process.Materials and Methods This study included sixteen patients with long bone metaphyseal and diaphyseal fractures and a healthy control group.Blood samples were taken at two timepoints: i) between the 1 st (the day of the fracture) and the 6 th day after fracture occurrence; ii) between the 7 th and the 21 st day after fracture occurrence.Fractures were treated either conservatively or surgically, depending on specific clinical indications.All participants with diaphyseal fractures were treated surgically.The control group provided blood samples on one occasion.The obtained plasma samples were pooled into 5 different experimental groups and analysed using commercial cytokine arrays.Results Marked differences in cytokine expression profiles were found between the fracture groups and the control group.The diaphyseal group had an "activated" pro-inflammatory cytokine profile with markedly higher levels of cytokines at both timepoints compared to the metaphyseal group, which in contrast had a "silenced" cytokine expression profile.Single cytokine analysis revealed that in both metaphyseal and diaphyseal fracture groups MCP-1 and RANTES showed the most prominent fold change at both timepoints.IL-6 and TNF-α also show similarly elevated levels in both timepoints in the diaphyseal fracture group, whereas this is not observed in the metaphyseal group.Furthermore, IL-3 expression was also elevated in the diaphyseal group, but only in the first timepoint.Conclusion This pilot study indicated chemokines which might be potential crucial drivers of bone healing, as well as painted distinct cytokine plasma profiles evident in metaphyseal and diaphyseal healing.
Genome Structures and Transcriptomes Signify Niche Adaptation for the Multiple-Ion-Tolerant Extremophyte <i>Schrenkiella parvula</i> (2014)

Schrenkiella parvula (formerly Thellungiella parvula), a close relative of Arabidopsis (Arabidopsis thaliana) and Brassica crop species, thrives on the shores of Lake Tuz, Turkey, where soils accumulate high concentrations of multiple-ion salts. Despite the stark differences in adaptations to extreme salt stresses, the genomes of S. parvula and Arabidopsis show extensive synteny. S. parvula completes its life cycle in the presence of Na⁺, K⁺, Mg²⁺, Li⁺, and borate at soil concentrations lethal to Arabidopsis. Genome structural variations, including tandem duplications and translocations of genes, interrupt the colinearity observed throughout the S. parvula and Arabidopsis genomes. Structural variations distinguish homologous gene pairs characterized by divergent promoter sequences and basal-level expression strengths. Comparative RNA sequencing reveals the enrichment of ion-transport functions among genes with higher expression in S. parvula, while pathogen defense-related genes show higher expression in Arabidopsis. Key stress-related ion transporter genes in S. parvula showed increased copy number, higher transcript dosage, and evidence for subfunctionalization. This extremophyte offers a framework to identify the requisite adjustments of genomic architecture and expression control for a set of genes found in most plants in a way to support distinct niche adaptation and lifestyles.
Structures of collagen IV globular domains: insight into associated pathologies, folding and network assembly. Corrigendum (2020)

[This corrects the article DOI: 10.1107/S2052252518012459.].
Cost optimal analysis and load shifting potentials of cold storage equipment (1995)

Cold storage systems are sized on the basis of economic considerations and constraints imposed by the cooling system components. In this study, a cost optimal analysis is presented for sizing cold storage equipment and a chiller. The analysis is based on life-cycle costs with energy rates for the City of Seattle. The optimal operating protocol for storage charging and discharging is determined by a dynamic programming method that minimizes the operating cost over an entire year. A sensitivity analysis is presented to provide insights into the importance of electricity rates and demand charges as they affect the optimal size of the storage and the chiller. Due to the extensive computation times for a whole year`s optimization, a reduction of the time horizon was investigated. The paper also discusses the economics of reducing the electric power demand during peak periods in terms of the reduction of peak electric power (kW) and electric energy (kWh). The paper will discuss the incremental cost for implementing full storage operation in which the entire cooling load is produced during off-peak hours.
Laminin promotes formation of cord-like structures by sertoli cells in vitro (1990)

Basement membranes are thin extracellular matrices which contact epithelial cells and promote their adhesion, migration, differentiation, and morphogenesis. These matrices are composed of collagen IV, heparan sulfate proteoglycan, laminin, and entactin as well as other minor components. Sertoli cells, like most epithelial cells, are in contact at their basal surface with a basement membrane. When cultured within three-dimensional basement membrane gels (Matrigel), Sertoli cells reorganize into cords that resemble testicular seminiferous cords found in the in vivo differentiating testis. Anti-laminin and anti-entactin antisera inhibit this cord morphogenesis by Sertoli cells whereas antisera against type IV and type I collagen, heparan sulfate proteoglycan, fibronectin, and preimmune sera had no effect. The RGD (RGDS-NH2) sequence, found in the cell binding domain of the integrin family of cell adhesion molecules as well as in the A chain of laminin and in entactin, effectively inhibited Sertoli cell cord formation at a concentration of 1.0 mg/ml but was unable to prevent Sertoli cell attachment at concentrations as high as 2.0 mg/ml. A synthetic pentapeptide from a cell-binding domain of the B1 chain of laminin. YIGSR-NH2, inhibited cord formation at a concentration of 0.25 mg/ml, but Sertoli cells were still adherent to the basement membrane matrix. At concentrations greater than 0.50 mg/ml, Sertoli cells detached. Antiserum against the YIGSR-NH2-containing sequence was also effective in inhibiting cord formation by Sertoli cells. Ligand (YIGSR-NH2 peptide) blot analysis of Sertoli cell lysates revealed an interaction with a major band at 60 kDa and with minor bands at 39 and 127 kDa. Furthermore, in Western blot analysis the anti-67-kDa laminin-binding protein antibody recognized a 59- to 60-kDa protein in Sertoli cells. The data indicate that laminin is involved in both Sertoli cell attachment and migration during formation of histotypic cord structures by these cells in culture. Two separate laminin cell-binding domains appear to be involved in Sertoli cell cord morphogenesis in vitro and are likely to participate in the formation of seminiferous cords in vivo.
Is the HERV-K HML-2 Xq21.33, an endogenous retrovirus mutated by gene conversion of chromosome X in a subset of African populations, associated with human breast cancer? (2020)

The human endogenous retroviruses HERV-K HML-2 have been considered a possible cause of human breast cancer (BrC). A HERV-K HML-2 fully intact provirus Xq21.33 was recently identified in some West African people. We used PCR technology to search for the Xq21.33 provirus in DNA from Nigerian women with BrC and controls. to see if Xq21.33 plays any role in predisposing to BrC. This provirus was detected in 27 of 216 (12.5%) women with BrC and in 22 of 219 (10.0%) controls. These results were not statistically significant. The prevalence of provirus in premenopausal control women 44 years or younger [18/157 (11.46%)} vs women with BrC [12/117 (10.26%)] showed no statistical difference. The prevalence of virus in postmenopausal control women > 45 yrs. was 7.4% (4/54) vs 15.31% (15/98) in postmenopausal women with BrC. These changes were not statistically significant at <.05, but the actual <i>p</i> value of <.0.079, suggests that Xq21.33 might play some role in predisposing to BrC in postmenopausal women. Provirus was present in Ghanaian women (6/87), in 1/6 Pygmy populations and in African American men (4/45) and women (6/68), but not in any Caucasian women (0/109). Two BrC cell lines (HCC 70 and DT22) from African American women had Xq21.33. E<i>nv</i> regions of the virus which differed by 2-3 SNPs did not alter the protein sequence of the virus. SNP at 5730 and 8529 were seen in all persons with provirus, while 54% had an additional SNP at 7596.Two Nigerian women and 2 Ghanaian women had additional unusual SNPs. Homozygosity was seen in (5/27) BrC and (2/22) control women. The genetic variation and homozygosity patterns suggested that there was gene conversion of this X chromosome associated virus. The suggestive finding in this preliminary data of possible increased prevalence of Xq21.33 provirus in post-menopausal Nigerian women with BrC should be clarified by a more statistically powered study sample to see if postmenopausal African and/or African American women carriers of Xq21.33 might show increased risk of BrC. The implication of finding such a link would be the development of antiretroviral drugs that might aid in preventing BrC in Xq21.33+ women.
Molecular diodes enabled by quantum interference (2014)

We use scanning tunneling microscope break-junction (STM-BJ) measurements to study the low-bias conductance and high-bias current-voltage (IV) characteristics of a series of asymmetric para-meta connected diphenyl-oligoenes. From tight-binding calculations, we determine that the quantum interference features inherent in our molecular design result in a 'through-bond' coupling on the para-side, and through-space coupling on the meta-side. We show that these molecular junctions form single molecule diodes, and show that the rectification results from a difference in the voltage dependence of the coupling strength on the through-bond and the through-space side. The interplay between the applied voltage and the molecule-metal coupling results from the asymmetric polarizability of the conducting orbital under an external field.
Automated provisioning method for a modular PON-OLT device toward Plug &amp; Provision (2020)

We propose a new automation concept for access network equipment called “Plug &amp; Provision.” This concept aims at reducing the workload in provisioning passive optical network (PON) service by utilizing a modular optical line terminal (OLT) and automating the setup sequence. To realize this concept, the automation platform must automatically detect the modular OLT plugged into a switch port and execute the configuration sequence that it triggered. We utilize open-source software in the control/management layer, especially focusing on OpenFlow as a control protocol. We present the overall architecture including a newly proposed PON abstraction and in-band control method for deeply disaggregated modular OLTs, and we demonstrate the feasibility of the architecture.
Families of maps Singularities and its Gauss maps (2011)

This paper mainly studies the Singularities of smooth mapping. The singularities of the families of Gauss maps corresponding to the family of mappings are studied and the shape of these families and their singularities using mathematica program are illustrated and plotted. (M. A. Soliman, Nassar. H. Abdel-All, Soad. A. Hassan and E. Dahi. Families of maps Singularities and its Gauss maps. Life Science Journal. 2011;8(3):482-487) (ISSN: 1097-8135). http://www.lifesciencesite.com.
Interparticle Collisions Driven by Ultrasound (1990)

Ultrasound has become an important synthetic tool in liquid-solid chemical reactions, but the origins of the observed enhancements remained unknown. The effects of high-intensity ultrasound on solid-liquid slurries were examined. Turbulent flow and shock waves produced by acoustic cavitation were found to drive metal particles together at sufficiently high velocities to induce melting upon collision. A series of transition-metal powders were used to probe the maximum temperatures and speeds reached during such interparticle collisions. Metal particles that were irradiated in hydrocarbon liquids with ultrasound underwent collisions at roughly half the speed of sound and generated localized effective temperatures between 2600 degrees C and 3400 degrees C at the point of impact for particles with an average diameter of approximately 10 microns.
Erfolgreiche Therapie eines konnatalen Chylothorax mit dem Somatostatin-Analogon Octreotid (2007)

Einleitung: Konservative Maßnahmen zur Behandlung eines konnatalen Chylothorax sind die Drainage des Pleuraspalts, eine extrem fettarme enterale Ernährung mit oraler Zufuhr von mittelkettigen Fettsäuren und schließlich die totale parenterale Ernährung. In 90% aller Fälle kann der Chylusfluss durch diese Maßnahmen zum Stillstand gebracht werden. Bei Versagen der konservativen Behandlung besteht jedoch eine Mortalität von 50%. In der Regel muss eine chirurgische Therapie durchgeführt werden. Octreotid, ein synthetisches Somatostatin-Analogon, wurde bei der Behandlung eines posttraumatischen Chylothorax sowohl bei Erwachsenen als auch bei Kindern erfolgreich eingesetzt. Einzelne Berichte existieren auch für die effektive Therapie des konnatalen Chylothorax. Wir berichten über ein weibliches Frühgeborenes der 35+2 SSW mit konnatalem Chylothorax, bei dem nach Versagen der üblichen konservativen Therapie durch die Behandlung mit Octreotid eine Operation vermieden werden konnte. Anamnese und Diagnostik: Bei einem weiblichen Frühgeborenen der 35+2 SSW wurde bereits intrauterin die Diagnose eines Hydrothorax gestellt. Eine begleitende Lungenhypoplasie konnte ausgeschlossen werden. Postnatal zeigte das Röntgenbild einen rechtsseitigen Pleuraerguss mit einer Spaltbreite von 1,2cm. Die Analyse des Pleurapunktats ergab ein für Chylus typisches protein- und lymphozytenreiches Sekret. Der Gehalt an Triglyceriden war aufgrund der noch nicht erfolgten enteralen Ernährung niedrig. In den Blutuntersuchungen fielen eine Hypoproteinämie, eine Verlängerung der PTT und ab der 3. Lebenswoche eine leichte Lymphozytopenie auf. Therapie und Verlauf: