gebhart/patrepeval huggingface dataset:
Continuous single sensillum recording as a detection method for moth pheromone components in the effluent of a gas chromatograph (1983)

ABSTRACT. Single sensillum recordings were made from male antennal pheromone receptors of Agrotis segetum (Schiff.) (Noctuidae) and Adoxophyes orana (F.v.R.) (Tortricidae). A gas chromatograph (GC) was used to prepare and to deliver the odour stimuli. Samples of female abdominal gland extracts were injected into the column of the GC and the responses of the receptor cells to the effluent were recorded continuously. The receptor cells responded with an increase of their action potential frequency during elution of the major pheromone components. The pheromone receptors of Agrotis showed a much higher sensitivity than those of Adoxophyes. In the extract of female glands from Agrotis , compounds were detected which have not been identified in previous studies of the sex pheromone of this species. It is suggested that the combination of GC techniques with direct single sensillum recording may serve as a valuable supplement to electro‐antennographic techniques.
A tangent formula derived from Patterson-function arguments. VI. structure solution from powder patterns with systematic overlap (1999)

Besides accidental peak overlap, systematic overlap constitutes one of the principal limitations for the solution of crystal structures from powder diffraction data. Unlike accidental overlap which affects all types of structures, systematic overlap is restricted to high-symmetry structures ( e.g. 65% of the space groups compatible with a hexagonal lattice). In this work, the direct-methods sum function is adapted to cope with data extracted from patterns containing systematic overlap. Preliminary results indicate that at least for moderate-size inorganic structures, systematic overlap should not represent a serious drawback for the application of direct methods. In contrast to the usual two-stage procedures employed for solving structures with accidental overlap, here both multiplet decomposition and phase refinement are carried out simultaneously. This procedure is illustrated using two examples: the dominant crystalline phase of a hydrated high-alumina cement and the fibrous alumino-silicate `aerinite'.
Análisis multicapa de composites. Aplicación al estudio interlaminar de techos de autobuses (1986)

Se expone en este trabajo un estudio teórico-experimental relativo al aspecto multicapas de materiales composites. La campaña de ensayos de laboratorio se ha efectuado en colaboración con Cristalería Española, S.A. en la parte final del artículo, se describe una aplicación a techos de autobús realizados en poliéster reforzado con fibra de vidrio, tema de gran actualidad debido a la reciente aparición del reglamento 36 de homologación de autobuses. Esta aplicación se ha llevado a cabo de forma conjunta con la empresa Hispano Carrocera, S.A. Summary This paper exposes a theoretical and experimental study relative to the multilayer aspect of the composite materials. The laboratory tests have been made with the gentle collaboration of Cristalería Española, S.A. In the last part of the paper, an application to bus ceilings made of glass fibre-reinforced polyester is described. This is a subject of actuality due to the recent publication of the 36th normative of buses homologation. This application has been made in collaboration with the firm Hispano Carrocera, S.A.
National treatment practices in the management of infectious intracranial aneurysms and infective endocarditis (2015)

In this NIS database study, the majority of patients with IIAs were managed non-operatively, regardless of rupture status. Further investigation is warranted to standardize the management of these lesions.
Novel Use of <i>Helicobacter pylori</i> Nitroreductase (<i>rdxA</i>) as a Counterselectable Marker in Allelic Vector Exchange to Create <i>Legionella pneumophila</i> Philadelphia-1 Mutants (2014)

This chapter tests the feasibility of replacing the sacB gene with another suicide gene, rdxA, from Helicobacter pylori, which encodes an NADPH oxygen insensitive nitroreductase. The authors show that the improved suicide vector pKBOXR (rdxA) and use of metronidazole in counterselection is superior to the sacB in Legionella pneumophila. Helicobacter pylori rdxA encodes an oxygen insensitive NADPH nitroreductase which exhibits high substrate specificity for the prodrug metronidazole, which is rapidly reduced to DNA damaging adducts of hydroxylamine, a bactericidal agent, thereby acting as a potential and novel counterselectable marker To create a gene knockout construct, flanking regions of ~500 bp of the targeted gene were individually PCR amplified and ligated into the multiple cloning site of an appropriate high-copy cloning vector (i.e., pBluescript, pUC19), after which an antibiotic cassette (kanamycin or gentamicin) was inserted between the two flanking regions. To date, utilization of the novel allelic exchange vector pKBOXR in our laboratory has generated several successful chromosomal gene knockouts of ahpC1, ahpC2D, ihfA, and ihfB in L. pneumophila Lp02. The pKBOXR vector appears to be more efficient than pBOC20 in generating knockout gene mutant strains, with the additional benefit that L. pneumophila is not subjected to osmotic stress during the counterselectable process.
Facilitating meetings with playful feedback (2010)

Effective group meetings are important for the productivity of corporations. Various types of meeting facilitators have been developed over the past couple of years. We present a prototype that is unique because it captures both individual and group behaviors and provides real time playful feedback. The portable prototype includes a set of table-top microphones with an audio interface to a laptop PC, where audio data are processed and an avatar-based UI displays the shared state of individual and group behaviors during a meeting. The interface reveals not only level of participation, but also several other meaningful but harder to detect behaviors such as turn taking, interruptions, and group laughter. The presentation's design is deliberately playful to keep participants monitor, self-estimate and improve their meeting behavior.
A semantic-based conversational agent framework (2009)

This paper focuses on the implementation of a novel semantic-based Conversational Agent (CA) framework. Traditional CA frameworks interpret scripts consisting of structural patterns of sentences. User input is matched against such patterns and an associated response is sent as output. This technique, which takes into account solely surface information, that is, the structural form of a sentence, requires the scripter to anticipate the inordinate ways that a user may send input. This is a tiresome and time-consuming process. As such, a semantic-based CA that interprets scripts consisting of natural language sentences will alleviate such burden. Using a pre-determined, domain-specific scenario, the CA was evaluated by participants indicating promising results.
5‐(Pyren‐1‐yl)uracil as a Base‐Discriminating Fluorescent Nucleobase in Pyrrolidinyl Peptide Nucleic Acids (2011)

A pyrene-labeled uridine (U(Py)) monomer for a pyrrolidinyl peptide nucleic acid with an alternating proline/2-aminocyclopentanecarboxylic acid backbone (acpcPNA) was synthesized and incorporated into the PNA. The U(Py) base in acpcPNA could specifically recognize the base A in its complementary DNA strand as determined by thermal denaturation (T(m)) experiments. The fluorescence of the U(Py)-containing single-stranded acpcPNA was very weak in aqueous buffer. In the presence of a complementary DNA target, the fluorescence was enhanced significantly (2.7-41.9 folds, depending on sequences). The fluorescence enhancement was specific to the pairing between U(Py) and dA, making the U(Py)-modified acpcPNA useful as a hybridization-responsive fluorescence probe for DNA-sequence determination.
MAGIC and H.E.S.S. detect VHE gamma rays from the blazar OT081 for the first time: a deep multiwavelength study (2021)

OT 081 is a luminous blazar well known for its variability in many energy bands. The very-high-energy (VHE; E >100 GeV) gamma-ray emission from the source was discovered by MAGIC and H.E.S.S. during flaring activity in July 2016, after a trigger from the Large Area Telescope (LAT) onboard the Fermi satellite. By analysing the multiwavelength light curves andthe broadband spectral energy distribution (SED), we study the activity of the source and investigate four individual states of activity in the window from MJD 57575 to 57602. The intrinsic gamma-ray spectrum can be described by a power law with spectral indices of 3.27 ± 0.44(MAGIC)and 3.39 ± 0.58(H.E.S.S.) over energy ranges 60–300 GeV and 120–500 GeV, respectively. The combined contemporaneous high-energy (HE;E >100 MeV) through VHE SED shows curvatureand can be described by a log-parabola shape. A simple one-zone synchrotron self-Compton (SSC)model is not sufficient to describe the broadband SED. The presence of broad emission lines in the optical spectrum of the source challenges the categorisation of OT 081 as a BL Lac and, together with the emission scenarios tested, points to the possibility that the source is transitional in nature between a BL Lac and a flat-spectrum radio quasar.
Intestinal Absorption and Tissue Distribution of [14C]Pyrroloquinoline Quinone in Mice (1991)

Pyrroloquinoline quinone (PQQ) functions as a cofactor for prokaryotic oxidoreductases, such as methanol dehydrogenase and membrane-bound glucose dehydrogenase. In animals fed chemically defined diets, PQQ improves reproductive outcome and neonatal growth. Consequently, the present study was undertaken to determine the extent to which PQQ is absorbed by the intestine, its tissue distribution, and route of excretion. About 28 micrograms of PQQ (0.42 microCi/mumol), labeled with 14C derived from L-tyrosine, was administered orally to Swiss-Webster mice (18-20 g) to estimate absorption. PQQ was readily absorbed (62%, range 19-89%) in the lower intestine, and was excreted by the kidneys (81% of the absorbed dose) within 24 hr. The only tissues that retained significant amounts of [14C]PQQ at 24 hr were skin and kidney. For kidney, it was assumed that retention of [14C]PQQ represented primarily PQQ destined for excretion. For skin, the concentration of [14C]PQQ increased from 0.3% of the absorbed dose at 6 hr to 1.3% at 24 hr. Furthermore, most of the [14C]PQQ in blood (greater than 95%) was associated with the blood cell fraction, rather than plasma.
IgG Glyco-Engineering to Improve IVIg Potency (2018)

Intravenous immunoglobulins (IVIg) are used in the treatment of different autoimmune and inflammatory diseases, such as immune thrombocytopenia and hemolytic anemia. One of the modes of action of IVIg is preventing phagocytosis of autoantibody-opsonized blood cells by saturation of the Fc-gamma receptors of macrophages in spleen and liver. IgG contains a fixed glycan, which is in most cases biantennary, at the asparagine residue at position 297 in the Fc tail. This glycan consists of a core structure of N-acetyl glucosamine (GlcNAc) and mannose groups, variably extended with core fucose, bisecting GlcNAc as well as terminal galactose and sialic acid. This structural glycan influences the binding affinity of IgG to Fc-gamma receptors. By glyco-engineering, we generated monoclonal IgG antibodies with different Fc-tail glycans and tested both their opsonizing and blocking capacity in a phagocytosis assay of IgG-opsonized erythrocytes with human monocyte-derived macrophages. In contrast to a lack of effect in opsono-phagocytosis, these IgG glycovariants differentially inhibited the uptake of opsonized erythrocytes. The level of bisecting GlcNAc and galactosylation had unexpectedly larger impact than core fucosylation, and suggest that targeted modifications different from the core fucose may well improve the immunomodulating efficacy of IVIg treatment.
New Onset Autoimmune Diseases after the Sputnik Vaccine (2023)

The vertiginous advance for identifying the genomic sequence of SARS-CoV-2 allowed the development of a vaccine including mRNA-based vaccines, inactivated viruses, protein subunits, and adenoviral vaccines such as Sputnik. This study aims to report on autoimmune disease manifestations that occurred following COVID-19 Sputnik vaccination. Patients and Methods: A retrospective study was conducted on patients with new-onset autoimmune diseases induced by a post-COVID-19 vaccine between March 2021 and December 2022, in two referral hospitals in Mexico City and Argentina. The study evaluated patients who received the Sputnik vaccine and developed recent-onset autoimmune diseases. Results: Twenty-eight patients developed recent-onset autoimmune diseases after Sputnik vaccine. The median age was 56.9 ± 21.7 years, with 14 females and 14 males. The autoimmune diseases observed were neurological in 13 patients (46%), hematological autoimmune manifestations occurred in 12 patients (42%), with thrombotic disease observed in 10 patients (28%), and autoimmune hemolytic anemia in two patients (7.1%). Rheumatological disorders were present in two patients (7.1%), and endocrine disorders in one patient (3.5%). Principio del formulario Conclusion: Although the COVID-19 Sputnik vaccine is generally safe, it can lead to adverse effects. Thrombosis and Guillain-Barre were the most frequent manifestations observed in our group of patients.
Influence of Disulfide Bonds on the Conformational Changes and Activities of Refolded Phytase (2005)

Aspergillus sp. phytase contains five disulfide bonds. In order to elucidate their role, the reactivation and refolding of phytase in the absence and presence of dithiothreitol (DTT) was investigated. The results indicated that the disulfide bonds play an important role in the catalytic activity and conformational stability of the enzyme.
Single-Dislocation Schottky Diodes (2021)

Dislocations often exhibit unique physical properties distinct from those of the bulk material. However, functional applications of dislocations are challenging due to difficulties in the construction of high-performance devices of dislocations. Here we demonstrate unidirectional single-dislocation Schottky diode arrays in a Fe<sub>2</sub>O<sub>3</sub> thin film on Nb-doped SrTiO<sub>3</sub> substrates. Conductivity measurements using conductive atomic force microscopy indicate that a net current will flow through individual dislocation Schottky diodes under forward bias and disappear under reverse bias. Under cyclic bias voltages, the single-dislocation Schottky diodes exhibit a distinct resistive switching behavior containing low-resistance and high-resistance states with a high resistance ratio of ∼10<sup>3</sup>. A combined study of transmission electron microscopy and first-principles calculations reveals that the Fe<sub>2</sub>O<sub>3</sub> dislocations comprise mixed Fe<sup>2+</sup> and Fe<sup>3+</sup> ions due to O deficiency and exhibit a one-dimensional electrical conductivity. The single-dislocation Schottky diodes may find applications for developing ultrahigh-density electronic and memory devices.
Laser Induced Transient Structures in a 150 nm Gold Crystal (2007)

Abstract The evolution of transient structures induced in gold crystals by irradiation with 400 nm, 100 fs laser pulses has been measured by means of time resolved x‐ray diffraction. The data show that the photon/electron interaction generates a hot electron wave on a 150 nm Au crystal, which is responsible for a “blast force” that generates an intense shock wave that alters the lattice structure as it propagates, with sound velocity, through the bulk of the crystal. This mechanical force is developed within 1‐2 ps after the laser pulse interacts with the gold surface electrons. Other major effects that have contributed to the strain in the lattice have also been evaluated.
Evidence of Muller’s ratchet in herpes simplex virus type 1 (2012)

Population bottlenecks can have major effects in the evolution of RNA viruses, but their possible influence in the evolution of DNA viruses is largely unknown. Genetic and biological variation of herpes simplex virus type 1 (HSV-1) has been studied by subjecting 23 biological clones of the virus to 10 plaque-to-plaque transfers. In contrast to large population passages, plaque transfers led to a decrease in replicative capacity of HSV-1. Two out of a total of 23 clones did not survive to the last transfer in 143 TK(-) cells. DNA from three genomic regions (DNA polymerase, glycoprotein gD and thymidine kinase) from the initial and passaged clones was sequenced. Nucleotide substitutions were detected in the TK and gD genes, but not in the DNA polymerase gene. Assuming a uniform distribution of mutations along the genome, the average rate of fixation of mutations was about five mutations per viral genome and plaque transfer. This value is comparable to the range of values calculated for RNA viruses. Four plaque-transferred populations lost neurovirulence for mice, as compared with the corresponding initial clones. LD(50) values obtained with the populations subjected to serial bottlenecks were 4- to 67-fold higher than for their parental clones. These results equate HSV-1 with RNA viruses regarding fitness decrease as a result of plaque-to-plaque transfers, and show that population bottlenecks can modify the pathogenic potential of HSV-1. Implications for the evolution of complex DNA viruses are discussed.
Effects of hypothyroidism on cell proliferation and neuroblasts in the hippocampal dentate gyrus in a rat model of type 2 diabetes (2010)

We observed how the hypothyroid state affects diabetic states and modifies cell proliferation and neuroblast differentiation in the hippocampal dentate gyrus (DG). For this, 0.03% methimazole, an anti-thyroid drug, was administered to 7-week-old, pre-diabetic Zucker diabetic fatty (ZDF) rats by drinking water for 5 weeks, and the animals were sacrificed at 12 weeks of age. At this age, corticosterone levels were significantly increased in the ZDF rats compared to those in the control (Zucker lean control, ZLC) rats. Methimazole (methi) treatment in the ZDF rats (ZDF-methi rats) significantly decreased corticosterone levels and diabetes-induced hypertrophy of adrenal glands. In the DG, Ki67 (a marker for cell proliferation)- and doublecortin (DCX, a marker for neuronal progenitors)-immunoreactive cells were much lower in the ZDF rats than those in the ZLC rats. However, in ZDF-methi rats, numbers of Ki67- and DCX-immunoreactive cells were similar to those in the ZLC rats. These suggest that methi significantly reduces diabetes-induced hypertrophy of the adrenal gland and alleviates the diabetes-induced reduction of cell proliferation and neuronal progenitors in the DG.
Supplementary Figure 2 from A Small Molecule Reacts with the p53 Somatic Mutant Y220C to Rescue Wild-type Thermal Stability (2023)

&lt;p&gt;Supplementary Figure S2: Differential scanning fluorimetry (A) Carbazole series plot of average values from differential scanning fluorimetry. (B) Indole series plot of average values from differential scanning fluorimetry. (C) Azaindole series plot of average values from differential scanning fluorimetry. (D) p53 Y220C-CL D228A DMSO or KG11 adduct plot of average values from differential scanning fluorimetry.&lt;/p&gt;
Optimal Link Scheduling in Millimeter Wave Multi-hop Networks with\n MU-MIMO radios (2019)

This paper studies the maximum throughput achievable with optimal scheduling\nin multi-hop mmWave picocellular networks with Multi-user Multiple-Input\nMultiple-Output (MU-MIMO) radios. MU-MIMO enables simultaneous transmission to\nmultiple receivers (Space Division Multiplexing) and simultaneous reception\nfrom multiple transmitters (Space Division Multiple Access). The main\ncontribution is the extension to MU-MIMO of the Network Utility Maximization\n(NUM) scheduling framework for multi-hop networks. We generalize to MU-MIMO the\nclassic proof that Maximum Back Pressure (MBP) scheduling is NUM optimal. MBP\nrequires the solution of an optimization that becomes harder with MU-MIMO\nradios. In prior models with one-to-one transmission and reception, each valid\nschedule was a matching over a graph. However, with MU-MIMO each valid schedule\nis, instead, a Directed Bipartite SubGraph (DBSG). In the general case this\nprevents finding efficient algorithms to solve the scheduler. We make MU-MIMO\nMBP scheduling tractable by assuming fixed power allocation, so the optimal\nscheduler is the Maximum Weighted DBSG. The MWDBSG problem can be solved using\nstandard Mixed Integer Linear Programing. We simulate multi-hop mmWave\npicocellular networks and show that a MU-MIMO MBP scheduler enables a 160%\nincrease in network throughput versus the classic one-to-one MBP scheduler,\nwhile fair rate allocation mechanisms are used in both cases.\n
ChemInform Abstract: POLY(IMINOMETHYLENES). 6. SYNTHESIS AND POLYMERIZATION OF α‐ AND β‐D‐GLUCOPYRANOSYL ISOCYANIDE (1978)

Abstract Aus den Glucosylbromiden (I) erhält man über einen Azidaustausch bei der Reduktion die Amine (IIb), die in Benzoyl‐ und Formyl‐Verbindungen (IIc) und (IId) übergeführt werden.
&lt;title&gt;Subwavelength imaging of an etched fiber with an intracore Bragg grating by apertured photon scanning tunneling microscope&lt;/title&gt; (1995)

Apertured photon scanning tunneling microscopy (APSTM) was used to image the internal structure of an etched optical fiber with an intracore Bragg grating. Direct evidence of the subwavelength periodic variation of the index of refraction along the fiber is obtained by probing evanescent field intensity modulated by the etched fiber grating structure. The images we observed suggests local non-uniformity in the grating structure. Local anomalies appear in the values of the grating spacing. The modulation of the evanescent field intensity originates from variations in the index of refraction as well as from surface structure induced by etching of the fiber.
[Hyperthyroidism in children (author's transl)]. (1982)

The present paper analyzes the causes, signs and symptoms of hyperthyroidism in children and the problems, complications and results associated with the various therapeutic regimes. Childhood hyperthyroidism is usually due to Grave's disease, an autoimmune thyroid disease. Genetic factors are also involved in its development. The diagnosis and in particular the differential diagnosis with Hashimoto's thyroiditis are discussed. Treatment of Graves' disease is controversial, but medical therapy is commonly accepted as the treatment of choice. Some dosage schedules of antithyroid drugs are considered, and some techniques for predicting remission status and relapse of disease are reported. Both the minor and more serious complications of medical therapy are examined. Careful follow-up for the development of hypothyroidism is advocated, especially in patients treated with radiation or surgery. Autonomous hyperfunctioning thyroid adenoma is rare, but occurs even in childhood, and can degenerate into carcinoma.
High-speed electro-optic control of the optical quality factor of a silicon microcavity (2008)

We demonstrate electro-optic ultrafast control of the optical quality factor of an on-chip silicon microcavity. The micrometer-sized cavity is formed by light confinement between two microring resonators acting as frequency selective mirrors. The ring resonators are integrated into p-i-n junctions enabling ultrafast injection and extraction of carriers. We show tuning of the cavity quality factor from 20,000 to 6,000 in under 100 ps. We demonstrate both high-Q to low-Q and low-Q to high-Q transitions.