gebhart/patrepeval huggingface dataset:
Characterization of a novel synapse-specific protein. I. Developmental expression and cellular localization of the F1-20 protein and mRNA (1992)

A molecular description of the nerve terminal will be required to understand synaptic function fully. The goals of this study were to contribute toward such a description by characterizing a novel synapse- specific protein. A monoclonal antibody library was screened for antibodies to synaptic proteins. The antibodies were then used to isolate cDNA clones by expression screening. Here we report a detailed characterization of the protein reactive with monoclonal antibody F1– 20. Immunohistochemical and biochemical analyses revealed that the F1– 20 protein is synapse associated. Western blot analyses revealed that the F1–20 protein is a brain-specific polypeptide with an apparent molecular weight on SDS-PAGE of 190,000 Da. Northern blot analyses indicated that probes generated from an F1–20 cDNA clone hybridize to a single brain-specific mRNA of approximately 4.8 kilobases. In situ hybridization experiments demonstrated that F1–20 mRNA expression is neuronal specific. Northern and Western blot analyses indicated that F1– 20 mRNA levels increase abruptly at postnatal day 4 and protein levels increase abruptly at postnatal day 7. This corresponds to a period of active synaptogenesis and synaptic maturation in the mouse CNS. We characterized the neuroanatomical distribution of the F1–20 protein by immunohistochemistry, and of the F1–20 mRNA by in situ hybridization. We found that the F1–20 mRNA and protein are expressed nonuniformly in brain. Variation in the expression of the F1–20 protein is complex and reveals patterns also exhibited by probes directed against other synapse-associated molecules. The highest levels of F1–20 protein are found in the cortically organized regions of the brain. The highest levels of F1–20 mRNA are found in long-distance projection neurons. There is also variation in the expression of F1–20 mRNA between different classes of large output neuron, as well as extensive variation in the expression of F1–20 mRNA between different nuclear groups.
Trade-off analysis between timing error rate and power dissipation for adaptive speed control with timing error prediction (2009)

Timing margin of a chip varies chip by chip due to manufacturing variability, and depends on operating environment and aging. Adaptive speed control with timing error prediction is a promising approach to mitigate the timing margin variation, whereas it inherently has a critical risk of timing error occurrence when a circuit is slowed down. This paper presents how to evaluate the relation between timing error rate and power dissipation in self-adaptive circuits with timing error prediction. The discussion is experimentally validated using a 32-bit ripple carry adder in subthreshold operation in a 90nm CMOS process. We show a trade-off between timing error rate and power dissipation, and reveal the dependency of the trade-off on design parameters.
Hydrothermal synthesis and characterization of a layered cobalt phenylphosphonate, Co(PhPO<sub>3</sub>)(H<sub>2</sub>O) (2005)

We report the hydrothermal synthesis and characterization of a layered cobalt phenylphosphonate. Unlike most metal phosphonates reported to date, the structure was solved by single crystal X-ray diffraction (SC-XRD). Co(ii) centres are hexa-coordinated by oxygen and the octahedra corner-share into a layer. The layers are capped by phenylphosphonate groups, where the phenyl groups define a hydrophobic bilayer region. The material was also characterized by powder X-ray diffraction (PXRD), thermogravimetric analysis (TGA) and SQUID (superconducting quantum interference device) magnetometry. The material undergoes an antiferromagnetic transition at a relatively low Néel temperature of 4.0 K, while the Curie-Weiss temperature of -76.5 K reflects the low-dimensionality of the magnetic structure. The effective magnetic moment of 5.01 micro(B) per Co(2+) verifies a high-spin configuration and an octahedral coordination of the metal centres. This layered material was correctly predicted in the literature from powder data, adds to the structural diversity of the cobalt phosphonates, and may be useful as an intercalation or exfoliation compound.
A New Approach of Dedusting for IGCC by a Two-Stage Moving Granular Bed Filter (2021)

We propose a dust removal technology in which a two-stage moving granular bed filter was employed using coarse and fine filtering granules. The pressure drop, collection efficiency, and dust particulate size distributions were investigated using various mass flow rates for coarse and fine granules at room temperature. In addition, the ratio of mass consumption was used to reveal the actual mass flow. The ratio of mass consumption influenced the pressure drop, collection efficiency, and dust particulate size distributions. Particulates larger than 1.775 μm were removed by the filter. Our results showed that a mass flow of 330 g/min for coarse granules and a mass flow of 1100 g/min for fine granules provided optimal collection efficiency and particulate size distribution. The proposed design can aid the development of high-temperature systems in power plants.
Planar Hall-Effect Bridge Sensor With NiFeX (X &lt;inline-formula&gt; &lt;tex-math notation="LaTeX"&gt;$=$ &lt;/tex-math&gt;&lt;/inline-formula&gt; Cu, Ag, and Au) Sensing Layer (2015)

This paper presents a new material alloy for planar Hall-effect bridge (PHEB) sensors and the accurate analysis of the resistance and sensitivity of these materials. The sensing layer is based on NiFeX (X = Cu, Ag, and Au). These alloys have a lower resistance without a significant loss of sensitivity. The presented PHEB sensors with NiFeX sensing layer show a coercivity of 1.7 Oe, lower than that of PHEB sensors with NiFe sensing layers, which have coercivities of 2.2 Oe.
Long term anticoagulation with low molecular weight heparin in outpatients with side effects on oral anticoagulants. (1989)

A total of 70 outpatients with previous severe haemorrhages and other side effects on conventional oral anticoagulants given for prophylaxis of tromboembolism, were treated with low molecular weight (LMW) heparin fraction Kabi 2165. Anticoagulation was necessary in all patients because of recurrent venous thromboembolism (n = 39), artificial heart valve replacement (n = 12), atrial fibrillation with peripheral embolism (n = 10), and cardiomyopathy (n = 9). LMW heparin was injected sc at doses ranging from 2,500 to 15,000 antifactor Xa (aXa) units once daily by the patients themselves. The dose was adjusted on the basis of body weight, of bleeding risk, and risk of developing thromboembolism. Five of 70 patients with poor compliance, 3 experienced non fatal embolism during the treatment period. Two of 65 patients with good compliance experienced repeat embolism. No fatal embolism occurred. One major episode of gastrointestinal bleeding occurred in a patient with an undetected colon carcinoma. Nine minor hemorrhages were observed in all patients. The present experience suggests that LMW heparin may be used safely and effectively as an alternative anticoagulant in patients who have experienced bleeding and other complications with oral anticoagulants or conventional heparin.
Electronic Structures and OH-Induced Atmospheric Degradation of CF<sub>3</sub>NSF<sub>2</sub>: A Potential Green Dielectric Replacement for SF<sub>6</sub> (2017)

Electronic structures of [(trifluoromethyl)imino]sulfur difluoride (CF<sub>3</sub>NSF<sub>2</sub>) and degradation mechanisms by hydroxyl radical have been investigated using density functional theory (M06-2X), the complete basis set quadratic CBS-Q, and the explicitly correlated coupled-cluster methods [CCSD(T)-F12]. The d-function augmented correlation-consistent basis sets including triple- and quadruple-ξ were employed for the sulfur-containing species. It was found that CF<sub>3</sub>NSF<sub>2</sub> exists as two conformations connected by the internal rotation of CF<sub>3</sub> around the central NS bond. The distorted syn conformer is more stable than the symmetrical anti conformer. The nitrogen-sulfur link in CF<sub>3</sub>NSF<sub>2</sub> was revealed to be predominantly ionic CF<sub>3</sub>N<sup>-</sup>-<sup>+</sup>SF<sub>2</sub> in structure rather than the conventional N═S double bond on the basis of natural bond orbital analysis. OH radical prefers to attach on the S atom of CF<sub>3</sub>NSF<sub>2</sub> along the opposite direction of the S-F bond via a nucleophilic addition mechanism with a barrier of 2.9 kcal/mol whereas the ON association pathway is negligible. Although many product channels are thermodynamically favorable, none of them is kinetically accessible because of the significant barriers along the reaction routes. However, the degradation of CF<sub>3</sub>NSF<sub>2</sub> by OH can be accelerated considerably in the presence of a single water molecule, which acts as a bridge for the consecutive proton migration within the floppy cyclic geometries. The half-life of CF<sub>3</sub>NSF<sub>2</sub> was estimated to be 2.5 year, and the final products are exclusively CF<sub>3</sub>NH and SF<sub>2</sub>O. Theoretical calculation supports that CF<sub>3</sub>NSF<sub>2</sub> is an environment-friendly green gas. It is worthy of testing its dielectric properties to replace SF<sub>6</sub> for practical use.
Predicting 30-Day Readmissions after Robotic Transhiatal Esophagectomy and the Impact of Readmission on Long-Term Survival (2023)

Ross, Sharona B MD, FACS; Jacoby, Harel MD; Sucandy, Iswanto MD; LaRocque, Breann BS; Syblis, Cameron; Crespo, Kaitlyn BS; Rosemurgy, Alexander S II MD, FACS Author Information
A Framework for End-to-End Evaluation of 5G mmWave Cellular Networks in ns-3 (2016)

The growing demand for ubiquitous mobile data services along with the scarcity of spectrum in the sub-6 GHz bands has given rise to the recent interest in developing wireless systems that can exploit the large amount of spectrum available in the millimeter wave (mmWave) frequency range. Due to its potential for multi-gigabit and ultra-low latency links, mmWave technology is expected to play a central role in 5th Generation (5G) cellular networks. Overcoming the poor radio propagation and sensitivity to blockages at higher frequencies presents major challenges, which is why much of the current research is focused at the physical layer. However, innovations will be required at all layers of the protocol stack to effectively utilize the large air link capacity and provide the end-to-end performance required by future networks. Discrete-event network simulation will be an invaluable tool for researchers to evaluate novel 5G protocols and systems from an end-to-end perspective. In this work, we present the first-of-its-kind, open-source framework for modeling mmWave cellular networks in the ns-3 simulator. Channel models are provided along with a configurable physical and MAC-layer implementation, which can be interfaced with the higher-layer protocols and core network model from the ns-3 LTE module to simulate end-to-end connectivity. The framework is demonstrated through several example simulations showing the performance of our custom mmWave stack.
Strain contouring with Gabor filters: filter bank design (2002)

A novel fringe processing method is proposed to segment whole-field strain distributions from interferometric deformation patterns by use of Gabor filters. This novel strategy is specifically proposed for strain measurement with a Gabor filter used as a set of wavelets. To increase computational speed as well as for selection of contour intervals, judicious design of the filter bank, based on the fringe pattern and the requirements of the user, is crucial in this methodology. A filter design strategy is developed and, based on the proposed filter design scheme, properly designed filter banks are generated and applied for strain contouring in low-strain and strain concentration regions. This scheme allows one to measure engineering strains within regions of interest and hence provides the design engineer great flexibility of monitoring, testing, or analysis.
High Numerical Aperture Diffractive Optics for Imaging Applications at 0.6 THz Frequency (2018)

High numerical aperture diffractive lenses such as conventional and combined zone plates, silicon based multilevel phase Fresnel zones were developed for high resolution THz imaging at the frequency range of 0.6 THz. Spectral features, spatial profiles, and focal depth characteristics are discussed, demonstrating the results to be in a good agreement with simulation data. In addition, new technique of the bifocal THz imaging is proposed.
Direct intralymphatic injection of peptide vaccines enhances immunogenicity (2005)

Research to enhance the efficiency of vaccines focuses mainly on improving either the adjuvant or the type and form of the antigen. This study evaluates the influence of the administration route on the efficiency of a peptide-based vaccine. Peptide vaccines are generally administered subcutaneously or intradermally, from where they must reach secondary lymphatic organs to induce an immune response. We analyzed the efficacy of peptide vaccines administered directly into a lymph node. Using a MHC class I-binding peptide from lymphocytic choriomeningitis virus, we found that intralymphatic injection enhanced immunogenicity by as much as 10(6) times when compared to subcutaneous and intradermal vaccination. Intralymphatic administration induced CD8 T cell responses with strong cytotoxic activity and IFN-gamma production that conferred long-term protection against viral infections and tumors. These results should have immediate implications for clinical immunotherapy of infectious disease and cancer.
Bismuth Chelate‐Doped Microfiltration Membrane and Its Anti‐Biofouling Performance During a High‐Flux Membrane Bioreactor Operation (2017)

The main disadvantage of membrane bioreactor (MBR) technology, which is an important alternative for advanced wastewater treatment, is fouling. In this regard, polyether sulfone (PES) membranes were prepared by adding bismuth 2,3‐dimercapto‐1‐propanol (BisBAL) chelate to the dope solution for biofouling control. BisBAL was synthesized using bismuth metal and a thiol. The bare and BisBAL‐doped PES membranes were tested for their physical properties and biofouling resistance properties using xanthan gum solution as a model foulant and real activated sludge. The results showed that the BisBAL‐doped PES membrane has a lower absorptive surface and fouling tendency when compared to the bare PES membrane. Bismuth release from BisBAL‐doped PES membrane during pure water filtration was measured using inductive‐coupled plasma spectrometry and the results showed that bismuth release from BisBAL‐doped PES membrane was quite low. According to the MBR operation results, it can be said that the rate of transmembrane pressure increase, total fouling and biofilm creation could be decreased with BisBAL‐doped PES membrane usage without any effect on activated sludge structure and microbial community population in the MBR. BisBAL‐doped PES membranes did not lose their durability and anti‐biofouling activities in time and could be chemically washed. The novelty of this study was the application of a microfiltration membrane manufactured with bismuth metal in MBR operation.
Locally adaptive learning for translation-variant MRF image priors (2008)

Markov random field (MRF) models are a powerful tool in machine vision applications. However, learning the model parameters is still a challenging problem and a burdensome task. The main contribution of this paper is to propose a locally adaptive learning framework. The proposed learning framework is simple and effective learning framework for translation-variant MRF models. The key idea is to use neighboring patches as a locally adaptive training set. We use multivariate Gaussian MRF models for local image prior models. Although the Gaussian MRF models are too simple for whole natural image priors, the locally adaptive framework enables to express the prior distributions of the every observed image. These locally adaptive learning framework and the multivariate Gaussian translation-variant MRF models simplify the learning procedures. This paper also includes other two contributions; a novel iteration framework by updating the prior information, and a simple and intuitive derivation of the well-known bilateral filter. Experimental results of denoising applications demonstrate that the denoising based on the proposed locally adaptive learning framework outperforms existing high-performance denoising algorithms.
New insights on the propagation of pulsed atmospheric plasma streams: From single jet to multi jet arrays (2015)

Atmospheric pressure plasma propagation inside long dielectric tubes is analyzed for the first time through nonintrusive and nonperturbative time resolved bi-directional electric field (EF) measurements. This study unveils that plasma propagation occurs in a region where longitudinal EF exists ahead the ionization front position usually revealed from plasma emission with ICCD measurement. The ionization front propagation induces the sudden rise of a radial EF component. Both of these EF components have an amplitude of several kV/cm for helium or neon plasmas and are preserved almost constant along a few tens of cm inside a capillary. All these experimental measurements are in excellent agreement with previous model calculations. The key roles of the voltage pulse polarity and of the target nature on the helium flow patterns when plasma jet is emerging in ambient air are documented from Schlieren visualization. The second part of this work is then dedicated to the development of multi jet systems, using two different setups, based on a single plasma source. Plasma splitting in dielectric tubes drilled with sub millimetric orifices, but also plasma transfer across metallic tubes equipped with such orifices are reported and analyzed from ICCD imaging and time resolved EF measurements. This allows for the design and the feasibility validation of plasma jet arrays but also emphasizes the necessity to account for voltage pulse polarity, target potential status, consecutive helium flow modulation, and electrostatic influence between the produced secondary jets.
TAS-121, A Selective Mutant EGFR Inhibitor, Shows Activity Against Tumors Expressing Various <i>EGFR</i> Mutations Including T790M and Uncommon Mutations G719X (2019)

TAS-121 is a novel orally active selective covalent inhibitor of the mutant EGFR. We performed preclinical characterization of TAS-121 and compared its efficacy and selectivity for common <i>EGFR</i> mutations (Ex19del and L858R), first- and second- generation EGFR-tyrosine kinase inhibitor (EGFR-TKI) resistance mutation (T790M), and uncommon mutations (G719X and L861Q) with those of other EGFR-TKIs. We also commenced investigation of the clinical benefits of TAS-121. The IC<sub>50</sub> for intracellular EGFR phosphorylation was determined by using Jump-In GripTite HEK293 cells transiently transfected with <i>EGFR</i> expression vectors. Mouse xenograft models were used to evaluate the antitumor activity of TAS-121. TAS-121 potently inhibited common activating and resistance EGFR mutations to the same extent as another third-generation EGFR-TKI (osimertinib). In addition, TAS-121 showed equivalent inhibitory activity against some uncommon mutations such as G719X and L861Q. Furthermore, TAS-121 demonstrated greater selectivity for mutant EGFRs versus the wild-type EGFR compared with other EGFR-TKIs. Moreover, TAS-121 displayed antitumor activity in SW48 (<i>EGFR</i> G719S) and NCI-H1975 (<i>EGFR</i> L858R/T790M) xenograft models, and achieved an objective response in patients with NSCLC with <i>EGFR</i> mutations including G719A mutation. In conclusion, TAS-121 is a novel third-generation EGFR-TKI and demonstrates antitumor activities in patients with NSCLC expressing either common or uncommon EGFR mutations.
Optimal binary phase-only matched filters (1988)

Many spatial light modulators and computer-generated hologram techniques can very efficiently implement binary phase-only filters. At present, almost all binary phase-only filters are designed by first designing a matched spatial filter and then binarizing it. There is no theoretical basis to expect that such a filter will be optimal. This paper first develops a theory for optimal binary phase-only filters and then presents a numerical algorithm which designs the optimal binary phase-only matched filter for a given image. The filter is optimal in the matched filter sense of maximizing SNR at the output origin. Characteristics of the optimal filter compared to conventional binary phase-only filters are discussed.
BDNF Regulates Atypical PKC at Spinal Synapses to Initiate and Maintain a Centralized Chronic Pain State (2013)

Hence, BDNF is a key regulator of aPKC synthesis and phosphorylation and an essential mediator of the maintenance of a centralized chronic pain state. These findings point to BDNF regulation of aPKC as a potential therapeutic target for the permanent reversal of a chronic pain state.
Building 235-F Goldsim Fate And Transport Model (2012)

Savannah River National Laboratory (SRNL) personnel, at the request of Area Completion Projects (ACP), evaluated In-Situ Disposal (ISD) alternatives that are under consideration for deactivation and decommissioning (D&D) of Building 235-F and the Building 294-2F Sand Filter. SRNL personnel developed and used a GoldSim fate and transport model, which is consistent with Musall 2012, to evaluate relative to groundwater protection, ISD alternatives that involve either source removal and/or the grouting of portions or all of 235-F. This evaluation was conducted through the development and use of a Building 235-F GoldSim fate and transport model. The model simulates contaminant release from four 235-F process areas and the 294-2F Sand Filter. In addition, it simulates the fate and transport through the vadose zone, the Upper Three Runs (UTR) aquifer, and the Upper Three Runs (UTR) creek. The model is designed as a stochastic model, and as such it can provide both deterministic and stochastic (probabilistic) results. The results show that the median radium activity concentrations exceed the 5 ?Ci/L radium MCL at the edge of the building for all ISD alternatives after 10,000 years, except those with a sufficient amount of inventory removed. A very interesting result was that grouting was shown to basically have minimal effect on the radium activity concentration. During the first 1,000 years grouting may have some small positive benefit relative to radium, however after that it may have a slightly deleterious effect. The Pb-210 results, relative to its 0.06 ?Ci/L PRG, are essentially identical to the radium results, but the Pb-210 results exhibit a lesser degree of exceedance. In summary, some level of inventory removal will be required to ensure that groundwater standards are met.
Configurational Analysis of Tetracyclic Dimeric Pyrrole–Imidazole Alkaloids Using a Floating Chirality Approach (2012)

The structure elucidation of the palau'amine congener tetrabromostyloguanidine (1), which used interproton distances from ROESY spectra as restraints in a computational approach, the so-called fc-rDG/DDD method, led to a revision of the relative configuration of palau'amine (2) and its congeners in 2007. The recent total synthesis of (±)-palau'amine (2) subsequently confirmed the computed structural revision of the relative configuration. In order to test a broader application range of the fc-rDG/DDD method, the present study investigated two additional dimeric pyrrole-imidazole alkaloids, axinellamine A (3) and 3,7-epi-massadine chloride (4). These calculations allowed the simultaneous assignment of the relative configuration for all eight stereogenic centers of compounds 3 and 4 without using any information from the reported configurations. In contrast to the palau'amine congeners, the fc-rDG/DDD method confirmed the relative configuration originally described for axinellamine A (3) and 3,7-epi-massadine chloride (4).