gebhart/patrepeval huggingface dataset:
The Interaction of the Medial Preoptic Area and the Dorsomedial-Ventromedial Nuclei of the Hypothalamus in the Regulation of the Mating-Induced Release of Prolactin (1985)

The medial preoptic area (MPOA) and the dorsomedial-ventromedial nuclei (DMN-VMN) of the hypothalamus regulate the mating-induced nocturnal and diurnal surges of prolactin in rats. The neural mechanisms governing the release of the two surges differ. For the nocturnal surge the MPOA serves an inhibitory role while the DMN-VMN serves a stimulatory role. The diurnal surge is controlled by both areas functioning as stimulatory centers. The goal of the present study was to explore the possibility of functional interactions between the MPOA and the DMN-VMN in control of mating-induced prolactin secretion. Stimulation of the MPOA in conscious, cervically stimulated (CS) females suppresses the nocturnal surge of prolactin. To determine if the inhibitory effects of the MPOA operate through the DMN-VMN, electrical stimulation was applied to the MPOA of conscious ovariectomized female rats bearing bilateral electrolytic lesions of the DMN-VMN. In the first experiment, control (sham-stimulated, sham-lesioned) CS females exhibited normal nocturnal surges which peaked at 03.00 h. MPOA stimulation (01.00-05.00 h) of both sham-lesioned and DMN-VMN lesioned CS females inhibited the release of their nocturnal surges. This suggests that the inhibitory function of the MPOA is independent of the DMN-VMN. MPOA stimulation can induce the release of a diurnal surge if the females are anesthetized with pentobarbital. In the second experiment, MPOA stimulation (15.00-19.00 h) of sham-lesioned anesthetized females produced elevated prolactin levels with significant peaks at 15.30 and 19.00 h. Anesthetized females with DMN-VMN lesions did not respond to MPOA stimulation with any change in prolactin secretion.(ABSTRACT TRUNCATED AT 250 WORDS)
Progress in CIGS solar cell technologies (2008)

Cu(In <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-x</sub> Ga <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> )Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (CIGS)-based solar cells have emerged as one of the most promising candidates for high-efficiency low-cost thin-film solar cells, and a significant improvement in solar cell performance has been reported with conversion efficiencies as high as eta=19.9%, though the efficiencies of commercial modules are limited to eta=11-12%. In Japan, the efficiency goal for 2030 is set to be eta=25% for small area cells and eta=22% for large-size modules, therefore improvement in conversion efficiencies for both cells and modules are required.
Comparison of Energy Efficiency of Various Ultrasonic Devices in Aquasonochemical Reactions (2006)

Abstract For economic reasons, reaction rate and energy efficiency of ultrasonic devices need to be higher. In this investigation, it was found that the 850 kHz ultrasonic device achieves a higher energy efficiency and a higher sonochemical reaction rate than the 24 or 30 kHz device during the oxidation of KI or the degradation of benzene in aqueous solutions. Moreover, lower power intensity or higher power density is generally favorable to the oxidation of KI. For benzene degradation, however, energy efficiency is enhanced with the increase in power intensity and density at lower input power and decreases with the increase in power intensity and density at higher input power. In addition, energy efficiency can also be diminished by changing fluid motion, for example, shortening the distance between the tip of the ultrasonic horn and the reactor bottom, and stirring during sonication.
Induction of glutathioneS-transferase-? in Barrett's metaplasia and Barrett's adenocarcinoma cell lines (1999)

Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for adenocarcinoma development, understanding the mechanisms that predispose the esophageal mucosa to malignant degeneration is clinically important. Glutathione s-transferase (GST)-pi belongs to a class of protective enzymes whose activity has been shown to be much lower in Barrett's metaplasia than in the normal esophagus, where this form of GST is predominant. In the studies described here, using immunocytochemical analysis, we observed higher levels of cytoplasmic GST-pi protein in normal esophageal mucosa than in Barrett's metaplasia. Using northern blot analysis, we also observed lower GST-pi mRNA levels in Barrett's metaplasia than in normal esophagus or adenocarcinomas from the same patients. Using as model systems three Barrett's adenocarcinoma cell lines and short-term organ culture of freshly resected normal esophagus and Barrett's metaplasia, dose-dependent induction of GST-pi mRNA was observed by using butylated hydroxyanisole and dexamethasone. GST-pi mRNA in Barrett's metaplasia was induced up to 2.5-fold with 60 microM butylated hydroxyanisole and nearly fivefold with 320 nM dexamethasone after 24 h. These studies demonstrate the ability to induce protective GST-pi in Barrett's metaplasia and may suggest a mechanism for future chemoprevention studies in patients with this type of epithelium, which is at high risk for malignant degeneration.
Probabilistic GNSS signal tracking for safety relevant automotive applications (2015)

Signal processing based on software defined radio (SDR) carries out innovative potential for advanced data fusion algorithms. In the field of satellite navigation, SDR is a key enabling technology for new integration approaches based on GNSS base band processing. As multipath and non-line-of-sight (NLOS) errors are the main challenge for GNSS in automotive applications, much research for the mitigation of those influences is still ongoing. Existing localization approaches are suitable to a limited extent for meeting the requirements of services and applications, especially in the context of driver assistance and autonomous driving where a proper computation of confidence levels is of mayor importance. If unhandled, multipath and NLOS errors introduce a bias to the GNSS observations resulting in an overestimation of the position confidence which violates the integrity of subsequent applications. This paper proposes an integrated probabilistic approach for a continuous implementation of the Bayesian framework within the signal processing of GNSS receivers. Special attention will be on modeling ambiguities on signal level that in traditional GNSS receivers ends up in multipath or NLOS errors. The idea is based on the theory of multiple object tracking to resolve ambiguities within the measurement space. The outcome of this paper is a model which condenses local error sources as generic system properties and proposes a Bayesian filter which improves the integrity and accuracy of the position estimate in urban areas without additional environmental knowledge. This approach is a step towards the applicability of low cost GNSS for safety relevant applications in the automotive area.
Important regulatory function of transient receptor potential ankyrin 1 receptors in age-related learning and memory alterations of mice (2019)

Expression of the transient receptor potential ankyrin 1 (TRPA1) receptor has been demonstrated not only in the dorsal root and trigeminal ganglia but also in different brain regions (e.g., hippocampus, hypothalamus, and cortex). However, data concerning their role in neurodegenerative and age-related diseases of the CNS is still indistinct. The aim of our study was to investigate the potential role of TRPA1 in a mouse model of senile dementia. For the investigation of changes during aging, we used male young (3-4-month-old) and old (18-month-old) wild-type (TRPA1<sup>+/+</sup>;WT) and TRPA1 receptor gene-deleted (TRPA1<sup>-/-</sup>) mice. Novel object recognition (NOR) test as well as Y maze (YM), radial arm maze (RAM), and Morris water maze (MWM) tests were used to assess the decline of memory and learning skills. In the behavioral studies, significant memory loss was detected in aged TRPA1<sup>+/+</sup> mice with the NOR and RAM, but there was no difference measured by YM and MWM tests regarding the age and gene. TRPA1<sup>-/-</sup> showed significantly reduced memory loss, which could be seen as higher discrimination index in the NOR and less exploration time in the RAM. Furthermore, young TRPA1<sup>-/-</sup> animals showed significantly less reference memory error in the RAM and notably higher mobility in NOR, RAM, and YM compared with the age-matched WTs. Our present work has provided the first evidence that TRPA1 receptors mediate deteriorating effects in the old age memory decline. Understanding the underlying mechanisms could open new perspectives in the pharmacotherapy of dementia.
Structural characterization of thiol-functionalized MCM-41 and MCM-48 mesoporous silicas for Hg(II) sorption (2006)

Congrès du 13.11.2006 au 17.11.2006
Single-shot dense active stereo with pixel-wise phase estimation based on grid-structure using CNN and correspondence estimation using GCN (2022)

Active stereo systems based on static pattern projection, a.k.a. oneshot scan, have been widely used for measuring dynamic scenes. Many patterns used for oneshot active stereo have grid-structures and grid-wise codes. For such systems, the grid structure is first detected, and graph matching methods are applied to estimate correspondences. However, such graph matching is often vulnerable to graph connection errors caused by grid structure analysis based on image features. Also, dense reconstruction for such systems is an open problem, where pixel-wise correspondence estimation from sparse image features is required. We propose a learning-based method to capture grid structure information and pixel-wise positional information simultaneously. We also propose to represent the grid structure by graphs with augmented connections other than 4-neighbor connections and applying them to a graph convolutional network (GCN). The proposed method can analyze large variety of grid patterns, has auto-calibration capability, can reconstruct dense shapes for fast moving objects.
Cortical Auditory Evoked Potentials in (Un)aided Normal-Hearing and Hearing-Impaired Adults (2016)

Cortical auditory evoked potentials (CAEPs) are influenced by the characteristics of the stimulus, including level and hearing aid gain. Previous studies have measured CAEPs aided and unaided in individuals with normal hearing. There is a significant difference between providing amplification to a person with normal hearing and a person with hearing loss. This study investigated this difference and the effects of stimulus signal-to-noise ratio (SNR) and audibility on the CAEP amplitude in a population with hearing loss. Twelve normal-hearing participants and 12 participants with a hearing loss participated in this study. Three speech sounds-/m/, /g/, and /t/-were presented in the free field. Unaided stimuli were presented at 55, 65, and 75 dB sound pressure level (SPL) and aided stimuli at 55 dB SPL with three different gains in steps of 10 dB. CAEPs were recorded and their amplitudes analyzed. Stimulus SNRs and audibility were determined. No significant effect of stimulus level or hearing aid gain was found in normal hearers. Conversely, a significant effect was found in hearing-impaired individuals. Audibility of the signal, which in some cases is determined by the signal level relative to threshold and in other cases by the SNR, is the dominant factor explaining changes in CAEP amplitude. CAEPs can potentially be used to assess the effects of hearing aid gain in hearing-impaired users.
Graphene–sponges as high-performance low-cost anodes for microbial fuel cells (2012)

A high-performance microbial fuel cell (MFC) anode was constructed from inexpensive materials. Key components were a graphene–sponge (G–S) composite and a stainless-steel (SS) current collector. Anode fabrication is simple, scalable, and environmentally friendly, with low energy inputs. The SS current collector improved electrode conductivity and decreased voltage drop and power loss. The resulting G–S–SS composite electrode appears promising for large-scale applications.
Propagation of optical pulses in photonic crystal waveguides (2004)

The dispersion properties of planar photonic crystal (PhC) coupled cavity waveguides are investigated. Both pulse broadening and compression have been demonstrated by propagating various chirped sub-picosecond pulses through the waveguides. The PhC waveguide exhibits large positive group-velocity dispersion (GVD), which is opposed to the negative GVD in a single-mode fibre (SMF). A maximum pulse width reduction of 40%, from 1.91 ps to 1.17 ps, is achieved, after transmission through an 8 μm long planar PhC waveguide. The equivalent dispersion value is &gt;106 times larger than that available from standard single-mode fibre at the pulse centre wavelength of 1536 nm.
Floquet topological insulators for sound (2016)

The unique conduction properties of condensed matter systems with topological order have recently inspired a quest for the similar effects in classical wave phenomena. Acoustic topological insulators, in particular, hold the promise to revolutionize our ability to control sound, allowing for large isolation in the bulk and broadband one-way transport along their edges, with topological immunity against structural defects and disorder. So far, these fascinating properties have been obtained relying on moving media, which may introduce noise and absorption losses, hindering the practical potential of topological acoustics. Here we overcome these limitations by modulating in time the acoustic properties of a lattice of resonators, introducing the concept of acoustic Floquet topological insulators. We show that acoustic waves provide a fertile ground to apply the anomalous physics of Floquet topological insulators, and demonstrate their relevance for a wide range of acoustic applications, including broadband acoustic isolation and topologically protected, nonreciprocal acoustic emitters.
Conformational Control of Intramolecular Electron Transfer in Calix[4]diquinones and Their Cationic Complexes (1998)

The synthesis is described of a photoactive molecular dyad comprising a luminescent ruthenium(II) tris(2,2‘-bipyridyl) fragment covalently attached, via a methylene bridge, to a calix[4]arene receptor in which two of the four walls are benzoquinone functions. A distribution of interconverting conformers is expected for the calix[4]arene platform, including cone, partial cone, and 1,3-alternated forms, according to molecular dynamics simulations and NMR studies. Luminescence from the metal complex is quenched because of light-induced electron transfer from the triplet state to a nearby quinone. The MD simulations indicate that the redox-active subunits approach within orbital contact of each other and that the noncone conformations adopt coparallel arrangements of the redox partners that appear to be highly favorable for electron transfer. Cations, such as barium(II), are held at the lower rim of the receptor by coordination to the four O atoms and by two N atoms provided by an ancillary 2,2‘-bipyridine that is appended to the receptor. Cation complexation increases slightly the thermodynamic driving force for light-induced electron transfer but restores luminescence from the ruthenium(II) tris(2,2‘-bipyridyl) fragment. This apparent contradiction is explained in terms of the cation inducing a major structural modification of the supermolecule. Both MD and NMR studies indicate that the cation forces the luminophore away from the quinone and, by favoring the cone conformation of the calix[4]arene, destabilizes cofacial orientations between closely spaced reactants. Consequently, the system functions as a sensitive photoionic detector.
A low latency and intuitive control video streaming system (2012)

Although demand for emergency medical services (EMS) is growing, sustaining EMS becomes more difficult and costly. It becomes a big problem, especially in Japan, that faces the problem of aging society. In this paper, we propose a smart EMS system. In order to increase efficiency of EMS, we focus on providing and sharing the information in real-time. In our system, Smart ambulance provides its location and patient information using video streaming in real-time. We realized a low latency streaming for communication, and remotely camera control system using touch panel. In evaluation, we showed that the video stream latency of our system was 45% lower than these of other methods.
Immediate or Delayed Nasal Reconstruction in Infant After Subtotal Amputation? (2008)

Nasal reconstruction using the forehead flap is one of the oldest recorded reconstructive procedures. The forehead flap is considered a standard for reconstruction of large defect. Most of reports concerning the forehead flap in nasal reconstructions deal with adults. Nasal reconstruction in infants raises some controversies, and very few articles report nasal reconstruction in the infants. A 15-month-old boy was presented after subtotal nasal amputation, after a dog bite. Microsurgical replantation was performed, but proved unsuccessful. The wound healed with debridement and local care. At age 2, nasal reconstruction was performed with autogenous ear cartilage and forehead flap. The reconstructed nose currently appears to be of good color, texture match, and functional. To our knowledge, few reconstructions of acquired nasal deformities using a forehead flap have been previously reported in infants. This 2-year-old patient may be among the youngest to have undergone this procedure. The forehead flap can be applied in very young children with reasonable expectations of excellent functional and esthetic outcome. Long-term results remain to be seen regarding nasal function and growth.
Automatic cellularity assessment from post‐treated breast surgical specimens (2017)

Neoadjuvant treatment (NAT) of breast cancer (BCa) is an option for patients with the locally advanced disease. It has been compared with standard adjuvant therapy with the aim of improving prognosis and surgical outcome. Moreover, the response of the tumor to the therapy provides useful information for patient management. The pathological examination of the tissue sections after surgery is the gold-standard to estimate the residual tumor and the assessment of cellularity is an important component of tumor burden assessment. In the current clinical practice, tumor cellularity is manually estimated by pathologists on hematoxylin and eosin (H&E) stained slides, the quality, and reliability of which might be impaired by inter-observer variability which potentially affects prognostic power assessment in NAT trials. This procedure is also qualitative and time-consuming. In this paper, we describe a method of automatically assessing cellularity. A pipeline to automatically segment nuclei figures and estimate residual cancer cellularity from within patches and whole slide images (WSIs) of BCa was developed. We have compared the performance of our proposed pipeline in estimating residual cancer cellularity with that of two expert pathologists. We found an intra-class agreement coefficient (ICC) of 0.89 (95% CI of [0.70, 0.95]) between pathologists, 0.74 (95% CI of [0.70, 0.77]) between pathologist #1 and proposed method, and 0.75 (95% CI of [0.71, 0.79]) between pathologist #2 and proposed method. We have also successfully applied our proposed technique on a WSI to locate areas with high concentration of residual cancer. The main advantage of our approach is that it is fully automatic and can be used to find areas with high cellularity in WSIs. This provides a first step in developing an automatic technique for post-NAT tumor response assessment from pathology slides. © 2017 International Society for Advancement of Cytometry.
Aeroallergens Derived from <i>Alternaria alternata</i> Stimulate COX2‐dependent Expression of Antioxidant Defense Enzymes in Human Bronchial Epithelial Cells (2015)

Alternaria aeroallergens stimulate allergic inflammation and exacerbation of respiratory distress in patients with asthma. Our previous studies have demonstrated that release of ATP and subsequent increases in intracellular [Ca 2+ ] was the result of Alternaria induced oxidative stress. Stimulation of Human Bronchial Epithelial Cells (HBECs) with Alternaria extract for 12 hours induced the expression of several phase II antioxidant enzymes, including cyclooxygenase 2 (COX2) which exhibited a 19 fold increase in mRNA expression. HBE cells loaded with CellRox™ Orange, a fluorogenic probe used for detecting oxidative stress, revealed that blocking COX2 inhibited resveratrol mediated inhibition of Alternaria induced oxidative stress. Furthermore induction of COX2 following Alternaria exposure was associated with an increase in expression of prostaglandin D 2 synthase and PGD 2 secretion into the extracellular media. Moreover, 15‐deoxy Δ 12,14 ‐protaglandin J 2 (15d‐PGJ 2 ) a metabolic product of PGD 2 was also shown to decrease Alternaria induced oxidative stress. These results suggest that upregulation of COX2 following sustained exposure to Alternaria induces PGD 2 synthesis and subsequent formation of 15d‐PGJ 2 , a known activator of Nrf2 signaling and ultimately, increased expression of phase II antioxidant enzymes.
Time dependence of hypoxia-specific accumulation of pimonidazole in rodent breast cancers (2010)

228 Objectives Imaging tumor hypoxia is an important goal, but defining “hypoxia” is challenging. Pimonidazole is often used as the “gold standard” to mark hypoxia in tissue. We studied the influence of the time interval between pimonidazole administration and sacrifice in rats with mammary cancer and compared the Pimonidazole accumulation to another hypoxia marker, GLUT1 expression. Methods Rat mammary tumors (RMT) were established in the interscapular subcutaneous region of Lewis rats. Pimonidazole (60mg/kg) was injected i.p. 1, 3, 6 or 12 hours before sacrifice of each rat. Hoechst 33342, a perfusion marker, was injected i.v. one minute before sacrifice. Tumors were removed and sections of three different parts of each tumor were made. The accumulation of pimonidazole and Hoechst 33342, and the expression of GLUT1 were evaluated using a confocal microscope. Correlation coefficients among Pimonidazole, GLUT1 and Hoechst33342 were calculated. Results Intratumoral pimonidazole accumulation pattern with 6- and 12-hour uptake intervals were substantially more focal than those seen with shorter uptake intervals where pimonidazole was distributed more diffusely. A negative correlation between pimonidazole accumulation and perfusion was far more evident in the 6-12 hour interval groups (r=-0.303, p Conclusions In rat mammary tumors, pimonidazole showed a considerably different intratumoral accumulation pattern dependent on the time between its administration and the time of sacrifice. Pimonidazole had much higher diffuse background in normoxic areas when assessed in a short uptake interval likely not accurately imaging hypoxia. Our studies illustrate the challenge of defining “hypoxia” in vivo even with a “gold standard” and support more than 6-hour delay from pimonidazole to sacrifice to best define hypoxia in this rat model