gebhart/patrepeval huggingface dataset:
System Non‐Linearities Induced by Skyhook Dampers (2001)

The nonlinearities induced by skyhook dampers are studied experimentally and analytically using a single degree of freedom base‐excited system that is representative of the systems that such dampers are often used in. The experimental results are used to show that the nonlinearities introduced by skyhook dampers manifest themselves as high frequency peaks in the frequency spectrum of the system response. More precisely, using a pure tone input with a known frequency, it is shown that these peaks occur at odd multiples of the system input (or driving) frequency. Using a Fourier series analysis, it is proven that the nonlinearities are caused by the switching policy of skyhook dampers, in which the damper force is changed according to the relative sign of the sprung mass absolute velocity and the relative velocity across the damper. The analysis shows that the skyhook damper force always contains a frequency component that is equal to the frequency of the system input (as is expected for a linear system), in addition to other frequencies that are odd multiples of the input frequency. The damping force peak that occurs at the input frequency is necessary for controlling the forced response of the system. The peaks at higher frequencies, however, are not desirable – although always present – because they introduce corresponding peaks in the system response that can cause ancillary vibration problems. For most systems, the high frequency peaks can significantly diminish any isolation benefits that are gained by the skyhook damper. When using skyhook dampers, such effects must be considered and their impact on the system dynamics studied carefully.
The Expression of Anti-Müllerian Hormone Type II Receptor (AMHRII) in Non-Gynecological Solid Tumors Offers Potential for Broad Therapeutic Intervention in Cancer (2021)

The anti-Müllerian hormone (AMH) belongs to the TGF-β family and plays a key role during fetal sexual development. Various reports have described the expression of AMH type II receptor (AMHRII) in human gynecological cancers including ovarian tumors. According to qRT-PCR results confirmed by specific In-Situ Hybridization (ISH) experiments, AMHRII mRNA is expressed in an extremely restricted number of normal tissues. By performing ISH on tissue microarray of solid tumor samples AMHRII mRNA was unexpectedly detected in several non-gynecological primary cancers including lung, breast, head and neck, and colorectal cancers. AMHRII protein expression, evaluated by immunohistochemistry (IHC) was detected in approximately 70% of epithelial ovarian cancers. Using the same IHC protocol on more than 900 frozen samples covering 18 different cancer types we detected AMHRII expression in more than 50% of hepato-carcinomas, colorectal, lung, and renal cancer samples. AMHRII expression was not observed in neuroendocrine lung tumor samples nor in non-Hodgkin lymphoma samples. Complementary analyses by immunofluorescence and flow cytometry confirmed the detection of AMHRII on a panel of ovarian and colorectal cancers displaying comparable expression levels with mean values of 39,000 and 50,000 AMHRII receptors per cell, respectively. Overall, our results suggest that this embryonic receptor could be a suitable target for treating AMHRII-expressing tumors with an anti-AMHRII selective agent such as murlentamab, also named 3C23K or GM102. This potential therapeutic intervention was confirmed in vivo by showing antitumor activity of murlentamab against AMHRII-expressing colorectal cancer and hepatocarcinoma Patient-Derived tumor Xenografts (PDX) models.
Grating enhanced back scatter fiber for distributed sensing (2016)

We demonstrate the sensing capability of a twisted multicore optical fiber with continuous grating enhanced back scatter. Our fiber allows spatially continuous temperature measurement in a sensor with more than 20dB round trip transmission loss.
cDNA cloning, expression and characterization of an allergenic L3 ribosomal protein of <i>Aspergillus fumigatus</i> (2003)

Aspergillus fumigatus (Afu) is an important fungal pathogen causing allergic and invasive respiratory disorders. A plethora of multi-functional allergens/antigens secreted by Afu have been implicated in pathogenesis. The present study was undertaken to identify and characterize novel Afu allergen/antigen by cDNA library approach. cDNA library of Afu was immunoscreened with pooled sera of allergic bronchopulmonary aspergillosis (ABPA) patients. The cDNA clone, TS1, reacting significantly with specific IgG antibodies, was selected. cDNA was subcloned and expressed in Escherichia coli. Sequencing of the cDNA revealed an open reading frame (ORF) of 1179 bases coding for a protein with an approximate molecular weight of 44 kDa. Immunoreactivity of the recombinant TS1 protein (rTS1) was evaluated by ELISA and Western blot analysis using pooled sera of ABPA patients. The rTS1 exhibited binding to specific IgG and IgE antibodies present in sera of ABPA patients. The deduced amino acid sequence showed homology to 60S ribosomal protein L3 (RpL3) of Aspergillus nidulans, Saccharomyces cerevisiae and Homo sapiens. The RpL3 of S. cerevesiae, tcm1, to which TS1 sequence shows significant homology (72% identity), is known to be responsible for conferring resistance against trichodermin (antibiotic, inhibiting protein synthesis). The present study has led to identification, cloning and expression of a 44-kDa novel allergen/antigen of Afu with sequence homology to L3 ribosomal protein with a probable role in resistance of Afu to antifungal drugs. Sixty-four per cent sequence identity of Afu RpL3 with human RpL3 and common regions in their predicted epitopes suggest a possibility of involvement of Afu RpL3 in autoimmune reactions due to molecular mimicry.
Thermal Analysis of the Iodine Satellite %28iSAT%29 (2015)

This paper presents the progress of the thermal analysis and design of the Iodine Satellite (iSAT). The purpose of the iSAT spacecraft (SC) is to demonstrate the ability of the iodine Hall Thruster propulsion system throughout a one year mission in an effort to mature the system for use on future satellites. The benefit of this propulsion system is that it uses a propellant, iodine, that is easy to store and provides a high thrust-to-mass ratio. The spacecraft will also act as a bus for an earth observation payload, the Long Wave Infrared (LWIR) Camera. Four phases of the mission, determined to either be critical to achieving requirements or phases of thermal concern, are modeled. The phases are the Right Ascension of the Ascending Node (RAAN) Change, Altitude Reduction, De-Orbit, and Science Phases. Each phase was modeled in a worst case hot environment and the coldest phase, the Science Phase, was also modeled in a worst case cold environment. The thermal environments of the spacecraft are especially important to model because iSAT has a very high power density. The satellite is the size of a 12 unit cubesat, and dissipates slightly more than 75 Watts of power as heat at times. The maximum temperatures for several components are above their maximum operational limit for one or more cases. The analysis done for the first Design and Analysis Cycle (DAC1) showed that many components were above or within 5 degrees Centigrade of their maximum operation limit. The battery is a component of concern because although it is not over its operational temperature limit, efficiency greatly decreases if it operates at the currently predicted temperatures. In the second Design and Analysis Cycle (DAC2), many steps were taken to mitigate the overheating of components, including isolating several high temperature components, removal of components, and rearrangement of systems. These changes have greatly increased the thermal margin available.
Development of home garden model for year round production and consumption for improving resource-poor household food security in Bangladesh (2016)

• A year round production system of fresh vegetables and fruits was tested.• After the intervention, the highest amount of vegetables was produced by the small farmer groups (511 kg/year) followed by marginal (499 kg/year) and landless (422 kg/year) farmers.• The yearly vegetable requirements of farmers were largely met by the homestead garden with a supply between 55 and 79 kg/head/year compared with the bench mark level of 21–30 kg/head/year before the intervention.• The upscaling of the production model based on niche/ecosystem in different poverty stricken regions of Bangladesh is recommended to achieve food security and malnutrition reduction.
Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein (2015)

Knowledge of the sequences and structures of proteins produced by microbial pathogens is continuously increasing. Besides offering the possibility of unraveling the mechanisms of pathogenesis at the molecular level, structural information provides new tools for vaccine development, such as the opportunity to improve viral and bacterial vaccine candidates by rational design. Structure-based rational design of antigens can optimize the epitope repertoire in terms of accessibility, stability, and variability. In the present study, we used epitope mapping information on the well-characterized antigen of Neisseria meningitidis factor H binding protein (fHbp) to engineer its gonococcal homologue, Ghfp. Meningococcal fHbp is typically classified in three distinct antigenic variants. We introduced epitopes of fHbp variant 1 onto the surface of Ghfp, which is naturally able to protect against meningococcal strains expressing fHbp of variants 2 and 3. Heterologous epitopes were successfully transplanted, as engineered Ghfp induced functional antibodies against all three fHbp variants. These results confirm that structural vaccinology represents a successful strategy for modulating immune responses, and it is a powerful tool for investigating the extension and localization of immunodominant epitopes.
Construction techniques of a molecular hydrogen laser (1985)

Simple techniques are described for construction of a discharge channel, and spark gap trigger electrode for a traveling-wave excited molecular hydrogen laser.
Pharmacological Inhibition of O-GlcNAc Transferase Promotes mTOR-Dependent Autophagy in Rat Cortical Neurons (2020)

O-GlcNAc transferase (OGT) is a ubiquitous enzyme that regulates the addition of β-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of target proteins. Autophagy is a cellular process of self-digestion, in which cytoplasmic resources, such as aggregate proteins, toxic compounds, damaged organelles, mitochondria, and lipid molecules, are degraded and recycled. Here, we examined how three different OGT inhibitors, alloxan, BXZ2, and OSMI-1, modulate O-GlcNAcylation in rat cortical neurons, and their autophagic effects were determined by immunoblot and immunofluorescence assays. We found that the treatment of cortical neurons with an OGT inhibitor decreased O-GlcNAcylation levels and increased LC3-II expression. Interestingly, the pre-treatment with rapamycin, an mTOR inhibitor, further increased the expression levels of LC3-II induced by OGT inhibition, implicating the involvement of mTOR signaling in O-GlcNAcylation-dependent autophagy. In contrast, OGT inhibitor-mediated autophagy was significantly attenuated by 3-methyladenine (3-MA), a blocker of autophagosome formation. However, when pre-treated with chloroquine (CQ), a lysosomotropic agent and a late-stage autophagy inhibitor, OGT inhibitors significantly increased LC3-II levels along with LC3 puncta formation, indicating the stimulation of autophagic flux. Lastly, we found that OGT inhibitors significantly decreased the levels of the autophagy substrate p62/SQSTM1 while increasing the expression of lysosome-associated membrane protein 1 (LAMP1). Together, our study reveals that the modulation of O-GlcNAcylation by OGT inhibition regulates mTOR-dependent autophagy in rat cortical neurons.
Stress changes induced at neighbouring faults by the June 2000 earthquakes, South Iceland Seismic Zone (2010)

The South Iceland Seismic Zone (SISZ) is an E-W trending active transform zone with high seismicity. N-S trending right-lateral strike-slip faults accommodate the left-lateral transform motion. Using seismological data recorded from 1991 to 2007, we carried out stress inversion of focal mechanisms of 1340 earthquakes that affected the Skard and Leirubakki faults, eastern SISZ. Not only did the inversion show typical deviations of stress across the faults, it also revealed anticlockwise and clockwise rotations of stress axes with time. Numerical models of the Leirubakki Fault show that these rotations are consistent with the mechanical effect of a lowered friction coefficient during the post-seismic period relative to the pre-seismic period. The Skard Fault reveals a more complex behaviour associated with a higher post-seismic friction, resulting from a higher density of pre-existing fracturing and probable stress interaction between faults. Our results suggest that faults where micro-earthquakes occur during neighbouring major seismic events may undergo significant stress changes at the scale of several kilometres and on time-scales of several years.
PUTATIVE VIRULENCE FACTORS OF <i>CANDIDA ALBICANS</i> (1991)

INTRODUCTION 187 Hypothetical Set of Virulence Genes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . 188 Commensal or Opportunistic Pathogen? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 188 Purpose of Review . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 189 HYPHAL PRODUCTION 190 Early Observation . . . . . . . . . .. . . , .... .. .. . . . . .. . . .. .. ...... . . . . . . . . .. . . . . . . .. .. . . . . . ,. 190 Inherent Experimental Diff iculties . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . 191 Recent Observations. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 193 Other Approaches. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 197 PROTEINASE ACTIVITy 197 Is There Only One Proteinase? 198 Evidence For and Against Proteinase . .... . . . . . . . . . . . . . . ....... ... . . . . . . ....... . . . . . .... . . ... 1 99 ADHERENCE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ... . . . . . . . . . . .. . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . . . 203 Classification of Receptor-Ligand Molecules . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 204 How Many Receptor-Ligand Molecules on C. albicans Are There? . . . . . . . . . . . . . . .... . 205 Virulence Role . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 206 VARIABILITY . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . .. . . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 207 Chromosomal Instabilities . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 208 Antigenic Variabilit y . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .. . . . . . . . 208 OTHER ATTRIBUTES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ,.. . . ...... . . . . . 209 Suppression-Activation of Host-Acquired Specific Immunity. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 209 CONCLUDING REMARKS 209
Infrastructure Support for Contention-Based Forwarding (2019)

Geocast is an important forwarding method for vehicular networks. One standard of vehicular communication is ETSI ITS-G5 GeoNetworking. One of the forwarding methods for geocast in this standard is Contention Based Forwarding (CBF). CBF is dependent on a favourable vehicle distribution to forward messages over multiple hops. A method to extend the effective range of vehicles is to use road side infrastructure to help forward messages. We propose a slightly modified CBF algorithm for road side infrastructure to enable infrastructure assisted forwarding for geocast messages, without modifying the CBF algorithm in the vehicles. In this paper we show that such a relatively small modification can significantly increase delivery rates while also reducing wireless load and delivery delays.
Linkage of familial essential tremor to chromosome 5q35 (2016)

A locus on chromosome 5 is linked to essential tremor. Further research is needed to identify a causative variant. © 2016 International Parkinson and Movement Disorder Society.
Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer Cells (2018)

Background/ Objective: Camel milk is traditionally known for its human health benefits and believed to be a remedy for various human ailments including cancer. The study was aimed to evaluate the inhibitory effects of commercially available camel milk on cancer cells and its underlying mechanism(s). Materials and Methods: Two cell lines: colorectal cancer HCT 116 and breast cancer MCF-7 were cultured with different doses of camel milk. The effects of camel milk on cell death were determined by MTT assay, viability by trypan blue exclusion assay and migration by in vitro scratch assay. The mechanism was elucidated by western blotting and confocal microscopy was used to confirm autophagy. Results: Camel milk significantly reduced proliferation, viability as well as migration of both the cells. The accumulation of LC3-II protein along with reduction in expression of p62 and Atg 5-12, the autophagy proteins implied induction of autophagy. The (GFP)-LC3 puncta detected by confocal microscopy confirmed the autophagosome formation in response to camel milk treatment. Conclusion: Camel milk exerted antiproliferative effects on human colorectal HCT 116 and breast MCF-7 cancer cells by inducing autophagy.
Cathodoluminescent Properties of Sol-Gel Derived Gd&lt;sub&gt;2&lt;/sub&gt;O&lt;sub&gt;3&lt;/sub&gt;:Eu Thin-Film Phosphors on Sapphire Substrates (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
The Association of Insomnia, Perceived Immune Functioning, and Irritable Bowel Syndrome Complaints (2018)

Experiencing IBS complaints is associated with reduced perceived immune functioning, a poorer perception of general health, and sleep disturbances. These effects are reflected in a significantly lower reported quality of life in subjects with more IBS and/or sleep complaints.
Error-Free Computation of 8x8 2-D DCT and IDCT Using Two-Dimensional Algebraic Integer Quantization (2005)

This paper presents a novel error-free (infinite-precision) architecture for the fast implementation of both 8/spl times/8 2D discrete cosine transform and inverse DCT. The architecture uses a new algebraic integer quantization of a 1D radix-8 DCT that allows the separable computation of a 2D 8/spl times/8 DCT without any intermediate number representation conversions. This is a considerable improvement on previously introduced algebraic integer encoding techniques to compute both DCT and IDCT which eliminates the requirements to approximate the transformation matrix elements by obtaining their exact representations and hence mapping the transcendental functions without any errors. Using this encoding scheme, an entire 8/spl times/8 1D DCT-SQ (scalar quantization) algorithm can be implemented with only 24 adders. Apart from the multiplication-free nature, this new mapping scheme fits to this algorithm, eliminating any computational or quantization errors and resulting short-word-length and high-speed-design.
Planetary-scale views on a large instant-messaging network (2008)

We present a study of anonymized data capturing a month of high-level communication activities within the whole of the Microsoft Messenger instant-messaging system. We examine characteristics and patterns that emerge from the collective dynamics of large numbers of people, rather than the actions and characteristics of individuals. The dataset contains summary properties of 30 billion conversations among 240 million people. From the data, we construct a communication graph with 180 million nodes and 1.3 billion undirected edges, creating the largest social network constructed and analyzed to date. We report on multiple aspects of the dataset and synthesized graph. We find that the graph is well-connected and robust to node removal. We investigate on a planetary-scale the oft-cited report that people are separated by "six degrees of separation" and find that the average path length among Messenger users is 6.6. We find that people tend to communicate more with each other when they have similar age, language, and location, and that cross-gender conversations are both more frequent and of longer duration than conversations with the same gender.
Galacto-oligosaccharides modulate the juvenile gut microbiome and innate immunity to improve broiler chicken performance (2019)

ABSTRACT Improvements in growth performance and health are key goals in broiler chicken production. Inclusion of prebiotic galacto-oligosaccharides in broiler feed enhanced the growth rate and feed conversion of chickens relative to a calorie-matched control diet. Comparison of the cecal microbiota identified key differences in abundance of Lactobacillus spp. Increased levels of L. johnsonii in GOS-fed juvenile birds at the expense of L. crispatus was linked to improved performance (growth rate and market weight). Investigation of the innate immune responses highlighted increases of ileal and cecal IL-17A gene expression counterposed to a decrease in IL-10 and IL-17F. Quantification of the autochthonous Lactobacillus ssp. revealed a correlation between bird performance and L. johnsonii abundance. Shifts in the cecal populations of key Lactobacillus spp. of juvenile birds primed intestinal innate immunity without harmful pathogen challenge. IMPORTANCE Improvements in the growth rate of broiler chickens can be achieved through dietary manipulation of the naturally occurring bacterial populations whilst mitigating the withdrawal of antibiotic growth promoters. Prebiotic galacto-oligosaccharides (GOS) are manufactured as a by-product of dairy cheese production, which can be incorporated in the diets of juvenile chickens to improve their health and performance. This study investigates the key mechanisms behind this progression and pin points L. johnsonii as a key species that facilitates the enhancements in growth rate and gut health. It also relates the role of the innate immune system in the response to the GOS diet.