gebhart/patrepeval huggingface dataset:
An architecture for extensible workflow process servers (1997)

Process-centered environments (PCEs) are viewed by many as a way around the crisis; they formalize development methodologies in enactable modeling languages (PMLs) that can be executed in order to provide various assistance modes to developers. These include, e.g. maintaining consistency, monitoring compliance with and/or actually enforcing the process, automation of routine activities, and guiding developers through the process.
Research has produced a variety of PCEs, each with its own PML, providing one or more assistance modes. However, no consensus has formed on such issues as the appropriate set of assistance modes, or the best software formalism; we doubt that there is a single best PML. Thus, for a development organization wishing to move to a process-based environment, there is a problem of competing formalisms--choosing an appropriate PCE, with its associated PML.
Problems can also arise in migrating to a PCE. Integrating the organization's development tools into the PCE is generally simple, but the also must be coded up in the PML, and the existing code immigrated into the PCE. This can present technical difficulties, but there are also serious organizational problems, notably training the developers, managers, etc., who know only the old legacy environment, to use the new PCE.
We address both problems: Competing formalisms, by translating high-level PMLs into a rule-based process assembly language (PAL), and legacy environments, by means of servers that provide enactment facilities to an existing environment, rather than taking over top-level control, as PCEs generally do. We present A scMBER, a engine with extensible PAL syntax and semantics tailorable to any desired assistance modes, as a kernel for servers supporting a wide range of PMLs. New enactment directives may be added to the syntax of the PAL, adding new assistance modes to A scMBER. The engine is parameterized by callbacks to mediator code in order to implement any new directives and to modify the enactment behavior. A scMBER's mediators also facilitate integration with a wide variety of environment architectures.
Haptic wrist guidance using vibrations for Human-Robot teams (2016)

Human-Robot teams can efficiently operate in several scenarios including Urban Search and Rescue (USAR). Robots can access areas too small or deep for a person, can begin surveying larger areas that people are not permitted to enter and can carry sensors and instruments. One important aspect in this cooperative framework is the way robots and humans can communicate during rescue operation. Vision and audio modalities may result not efficient in case of reduced visibility or high noise. A promising way to guarantee effective communications between robot and human in a team is the exploitation of haptic signals. In this work, we present a possible solution to let a robot guide the position of a human operator's hand by using vibrations. We demonstrate that an armband embedding four vibrating motors is enough to guide the wrist of an operator along a predefined path or in a target location. The results proposed can be exploited in human-robot teams. For instance, when the robot detects the position of a sensible target, it can guide the wrist of the operator in such position following an optimal path.
CLINICAL LARGE INTESTINAL COCCIDIOSIS IN CAMELS (CAMELUS DROMEDARIUS) IN THE UNITED ARAB EMIRATES: DESCRIPTION OF LESIONS, ENDOGENOUS STAGES, AND REDESCRIPTION OF ISOSPORA ORLOVI, TSYGANKOV, 1950 OOCYSTS (2002)

Between January and March 2001, eight 4- to 8-wk-old camels (Camelus dromedarius) from 2 farms from Dubai area of the United Arab Emirates were submitted for necropsy examination. The camels had diarrhea of 2-5 days duration. Grossly, a severe diphtheroid-to-hemorrhagic colitis was seen in all animals. Gamonts, unsporulated oocysts, sporulating oocysts, and fully sporulated oocysts were present in the intestinal epithelium and the lamina propria. Fully sporulated oocysts contained 2 sporocysts and 4 sporozoites in each sporocyst. Oocysts from fecal samples resembled oocysts of Isospora orlovi. This is the first report of an isosporan parasite associated with hemorrhagic enteritis in the large intestine of any animal.
Diverse biological characteristics and varied virulence of H7N9 from Wave 5 (2019)

There was a substantial increase with infections of H7N9 avian influenza virus (AIV) in humans during Wave 5 (2016-2017). To investigate whether H7N9 had become more infectious/transmissible and pathogenic overall, we characterized the receptor binding and experimentally infected ferrets with highly pathogenic (HP)- and low pathogenic (LP)-H7N9 isolates selected from Wave 5, and compared their pathogenicity and transmissibility with a Wave 1 isolate from 2013. Studies show that A/Anhui/1/2013 (LP) and A/Chicken/Heyuan/16876/2016 (HP) were highly virulent in ferrets, A/Guangdong/Th008/2017 (HP) and A/Chicken/Huizhou/HZ-3/2017 (HP) had moderate virulence and A/Shenzhen/Th001/2016 (LP) was of low virulence in ferrets. Transmission was observed only in ferrets infected with A/Anhui/1/2013 and A/Chicken/Heyuan/16876/2016, consistent with the idea that sicker ferrets had a higher probability to transmit virus to naive animals. Given the Varied virulence and transmissibility observed in circulating H7N9 viruses from Wave 5, we conclude that the current public health risk of H7N9 has not substantially increased compared to 2013 and the circulating viruses are quite diverse.
Development of a high-speed confocal line scanning FLIM microscope for live cell imaging (Conference Presentation) (2023)

We report the development of a novel confocal line-scanning microscope capable of acquiring video-frame rate TCSPC-based FLIM. The system consists of a one-dimensional laser beam, which is optically conjugated to a 1024×16 single photon avalanche diode(SPAD) based line-imaging CMOS(1), with 23.78 μm pixel pitch at 49.31% fill factor. Incorporation of on-chip histogramming on the line-sensor facilitates the acquisition of up to 16.5 Giga-photon counts/s, enabling operation 66 times faster than our previously reported bespoke high speed FLIM platforms. We will demonstrate its use in live-cell imaging investigating the roles that PAK proteins play in regulation of cytoskeletal dynamics.
Ionic Liquids - A Unique Palette to Create Advanced Electrolytes (2016)

The drive to identify high energy batteries remains an on-going challenge. There are two key R &amp; D thrusts at this time – next generation Lithium-ion batteries that (i) require the use of intercalation materials that can operate high voltages (5 V vs Li|Li + ) and (ii) alternative high energy density electrodes such as Sulfur (2567 Wh/kg) or the holy-grail for the field, an air breathing cathode (3505 Wh/kg). To harness these high energy densities Lithium metal anodes are required as one of very few alternatives. In both instances, there is a distinct need to develop electrolytes that are stable under strongly oxidising environments and strongly reductive environments, respectively. To this end, CSIRO has been actively researching ionic liquid electrolytes as an option to replace aprotic solvent based electrolytes in batteries. Ionic liquids have some unique properties in terms of negligible vapor pressure, relatively high conductivity, wide electrochemical windows and high thermal decomposition temperatures. This makes them ideally suited to a range of electrochemical storage devices, specifically those that are being targeted at this time. (i) High voltage lithium-ion batteries require electrolytes that are stable in contact with intercalation cathode at potentials &gt; 4.5 V (vs Li|Li + ) and do not cause Al current collector corrosion. To-date, there are very few materials that can achieve both of these goals. We will describe work we have been undertaking to determine failure modes of both active materials and electrode structures and the role of the electrolyte in solving these issues. (ii) Although a 10 fold increase in specific energy is possible with recent advances in Li-Sulfur (2567 Wh / kg) technologies, there are several challenges in the development of these devices. The most vexing of these challenges is the generation of lithium polysulfides which are highly prone to irreversibly move into the electrolyte media. These can have deleterious effects on the performance of the device such as reduced capacity and cycle-life. To overcome this problem, numerous different approaches have been trialled to “lock” S within a conductive structure / matrix whilst still making it available to lithium ions from the electrolyte to form the required lithium polysulfides that deliver the high capacity of the device. At CSIRO, we have been looking at a range of different methodologies to understand the formation of polysulfides both in the electrolyte and the cathode and then examine various methods to keep them electrically connected within the cathode. In this presentation, we will highlight our work methods to prevent polysulfide dissolution via changes to the electrolyte and the effect on cycling and in-situ studies at the Australian Synchrotron.
FLASH PHOTOLYSIS OF BOVINE SERUM ALBUMIN: IDENTIFICATION AND DECAY KINETICS OF TRANSIENT INTERMEDIATES (1978)

Abstract. Using the method of flash photolysis, the triplet of the single indole side chain of human serum albumin was detected at room temperature. In a nitrogen saturated solution, this species was found to decay exponentially for over a factor of ten with a lifetime τ 0.5 ms. Analogous experiments, reported here, with bovine serum albumin yield a non‐exponential decay which may be decomposed into two components. The yield of the longer lived triplet, with an average τ of ∼6 ms, is significantly enhanced by addition of a 20 fold excess of sodium dodecyl sulfate or 1 M Br ‐ . The yield of the shorter lived triplet, τ 0.4 ms, is unaffected by these treatments as was previously observed for the single indole in HSA. Thus, the short lived triplet may be assigned to the indole in BSA which is homologous to the one in HSA. The longer lived triplet may be assigned to the remaining indole of BSA. On the bases of wavelength dependence studies, two additional transients may be identified; the electron adduct of the disulfide bond, λ; 420 with a τ 30 ms, and the neutral indole radical,λ; 520 nm with τ ls. These results suggest that the triplet, because of its long τ, will be a valuable intrinsic reporter group for the study of the structure and dynamics of proteins in solution at room temperature.
A Study of a Fast Booting Technique for a New memory+DRAM Hybrid Memory System (2015)

Next generation memory technologies, which we denote as 'new memory', have both non-volatile and byte addressable properties. These characteristics are expected to bring changes to the conventional computer system structure. In this paper, we propose a fast boot technique for hybrid main memory architectures that have both new memory and DRAM. The key technique used for fast booting is write-tracking. Write-tracking is used to detect and manage modified data detection and involves setting the kernel region to read-only. This setting is used to trigger intentional faults upon modification requests. As the fault handler can detect the faulting address, write-tracking makes use of the address to manage the modified data. In particular, in our case, we make use of the MMU (Memory Management Unit) translation table. When a write occurs to the boot completed state, write-tracking preserves the original state of the modified address of the kernel region to a particular location, and execution continues. Upon booting, the fast booting process restores the preserved data to the original kernel region allowing rapid system boot-up. We develop the fast booting technique in an actual embedded board equipped with new memory. The boot time is reduced to less than half a second compared to around 15 seconds that is required for the original system.
Does a Low Level of Expression of HLA Molecules Engender Autoimmunity? (1999)

The immune system can summon a variety of defenses against invaders from the outside. Among these deterrents are three types of killer lymphocytes that attack and lyse cellular targets. One type consists of cytotoxic, or CD8, T cells with α/β antigen receptors that interact with the HLA class I glycoproteins on nearly all cells. These HLA molecules bind to peptides derived from intracellular antigens, such as viral proteins, and display them on the cell surface. Binding of the α/β antigen receptor to complexes of HLA class I molecules and peptide fragments of an invading virus induces the T lymphocyte to . . .
Poorer survival outcomes in patients with multiple versus single primary melanoma (2022)

Patients with MPMs had worse RFS and OS compared with patients with SPMs. Immunologic differences were also observed, including TIL content and expression of CXCL6/FOXJ1 in PBMCs of patients with MPMs, which warrant further investigation.
Stator circulating currents as media of fault detection in synchronous motors (2013)

Often found in critical, high power applications, synchronous machines require reliable condition monitoring systems. Large synchronous machines are typically designed with parallel connected windings in order to split the currents in parallel paths, delivering the total power at the terminals. Under ideal symmetrical conditions, no current will circulate between parallel branches of the same phase. However, when a motor fault breaks this symmetry, currents circulate between the branches. Thus, due to the fact that they are only non-zero under faulty conditions, circulating currents potentially represent a sensitive indicator of faulty condition. In this paper, the advantages of using the circulating current between parallel branches of the stator of a synchronous motor as an early indicator of motor faults are shown. Analysis is conducted both through simulation, via the use of finite element methods (FEM), and through experimentation using a specially-designed synchronous machine which allows various fault conditions to be investigated. Through comparison between experiment and simulation, the simulation tool is validated. Furthermore, it is shown that the circulating current is better suited for fault detection than either the branch or the stator current. It is concluded that an improved condition monitoring and protection system for a synchronous machine may be achieved if these currents are monitored.
Study of a Pilotless Fine Frequency Estimator Algorithm in Burst-mode PSK Transmissions (2019)

This work investigates the frequency estimation method and proposed an improved pilotless fine frequency estimator (FFE) algorithm for burst-mode (PSK) transmissions.The algorithm is data-aided (DA) and has an approach based on approximated Maximum Likelihood (ML).The simulations results obtained show us its estimation accuracy is close to the Modified Cramer-Rao Bound (MCRB) for a Signal-to-Noise (SNR) as low as 0 dB.Compared with theoretical solutions and based on the results obtained here, the estimator proposed is a good candidate for implementation in hardware.The algorithm is simple and easy to be implemented in digital form.The estimator was developed targeting a digital receiver for the DVB-S2 standard, that is under development in 65nm CMOS technology, and with minor changes it can also support DVB-S2X receivers or communication system that require the same constraints for low SNR (LSNR).
Optimization of iron oxide nanoparticle detection using ultrashort echo time pulse sequences: Comparison of <i>T</i><sub>1</sub>, <i>T</i><sub>2</sub>*, and synergistic <i>T</i><sub>1</sub> − <i>T</i><sub>2</sub>* contrast mechanisms (2011)

Abstract Iron oxide nanoparticles (IONPs) are used in various MRI applications as negative contrast agents. A major challenge is to distinguish regions of signal void due to IONPs from those due to low signal tissues or susceptibility artifacts. To overcome this limitation, several positive contrast strategies have been proposed. Relying on IONP T 1 shortening effects to generate positive contrast is a particularly appealing strategy because it should provide additional specificity when associated with the usual negative contrast from effective transverse relaxation time ( T 2 *) effects. In this article, ultrashort echo time imaging is shown to be a powerful technique which can take full advantage of both contrast mechanisms. Methods of comparing T 1 and T 2 * contrast efficiency are described and general rules that allow optimizing IONP detection sensitivity are derived. Contrary to conventional wisdom, optimizing T 1 contrast is often a good strategy for imaging IONPs. Under certain conditions, subtraction of a later echo signal from the ultrashort echo time signal not only improves IONP specificity by providing long T 2 * background suppression but also increases detection sensitivity, as it enables a synergistic combination of usually antagonist T 1 and T 2 * contrasts. In vitro experiments support our theory, and a molecular imaging application is demonstrated using tumor‐targeted IONPs in vivo. Magn Reson Med, 2011. © 2011 Wiley‐Liss, Inc.
Storage Temperature and Ethylene Influence on Ripening of Papaya Fruit (1990)

The temperature and ethylene response of ripening papaya fruit (Carica papaya L. cv . Sunset) was determined with and without 14 days of storage at 10C. Temperatures at or higher than 30C adversely affected the quality of the ripe papaya. Papayas held at 32.5C for 10 days failed to ripen normally, as evidenced by poor color development, abnormal softening, surface pitting, and an occasional off-flavor. Skin yellowing, fruit softening, and flesh color of papayas exhibited a quadratic response to ripening time within the temperature range of 22.5 to 27.5C. Flesh color development of nonstored fruit did not change significantly during the first 6 days at ripening temperatures, then rapidly increased. Fruit stored for 14 days at 10C exhibited faster ripening rates (e.g., degreening and softening and no delay in flesh color development) than nonstored fruit when removed to other ripening temperatures (17.5 to 32.5 C). Problems of weight loss and development of external abnormalities were more significant at temperatures higher than 27.5C. The optimal temperature range was found to be between 22.5 and 27.5C, with fruit taking 10 to 18 days to reach full skin yellowing from color break, whether or not fruit was stored at 10C. Exogenously applied ethylene (=100 μl·liter -1 ) stimulated the rate of fruit ripening, as measured by more uniform skin yellowing and rate of flesh softening whether or not the fruit were stored for 14 days at 10C. Ethylene did not ripen immature papayas completely in terms of skin and flesh color development. The outer portion of the flesh of ethylene-treated fruit had a faster rate of ripening, as indicated by carotenoid development and softening rate, while the same area of the flesh was still pale white in nonethylene-treated fruit. Ethylene reduced the coefficient of variation for skin color, softening rate, and flesh color development in treated fruit. Ethylene increased the rate of skin degreening and hastened the rate of carotenoid development and softening in the outer mesocarp, while having little effect on the inner mesocarp.
Integral variable structure current control of DFIG-based wind turbines near cut-in speed (2009)

Based on the grid voltage orientated vector control technique, a novel integral variable structure controller for current control of variable speed doubly fed induction generator (DFIG) wind turbines near cut-in wind speed is proposed. The proposed current controller can not only ensure generators' safe cut-in switches to the grid, but also maximum energy capture after switch motion without any regulations. By these, simulations of a 1.5 MW DFIG-based wind turbine near cut-in wind speed are separately conducted under integral variable structure control (IVSC) and PI control. The results show that IVSC strategy, which gives better dynamic response, less static error, smaller controller output dithering, stronger global robustness against generator parameters uncertainty and the grid voltage fluctuation, as well as needless controller regulation after cutting-in the grid, obviously preponderates over traditional PI control for DFIG-based wind turbines near cut-in speed.
<i>PTBP1</i> mRNA isoforms and regulation of their translation (2018)

Polypyrimidine tract-binding proteins (PTBPs) are RNA binding proteins that regulate a number of post-transcriptional events. Human PTBP1 transits between the nucleus and cytoplasm and is thought to regulate RNA processes in both. However, information about PTBP1 mRNA isoforms and regulation of PTPB1 expression remain incomplete. Here we mapped the major PTBP1 mRNA isoforms in HEK293T cells, and identified alternative 5' and 3' untranslated regions (5' UTRs, 3' UTRs) as well as alternative splicing patterns in the protein coding region. We also assessed how the observed PTBP1 mRNA isoforms contribute to PTBP1 expression in different phases of the cell cycle. Previously, PTBP1 mRNAs were shown to crosslink to eukaryotic translation initiation factor 3 (eIF3). We find that eIF3 binds differently to each PTBP1 mRNA isoform in a cell cycle-dependent manner. We also observe a strong correlation between eIF3 binding to PTBP1 mRNAs and repression of PTBP1 levels during the S phase of the cell cycle. Our results provide evidence of translational regulation of PTBP1 protein levels during the cell cycle, which may affect downstream regulation of alternative splicing and translation mediated by PTBP1 protein isoforms.
I'm Not Going to Pay a Lot for This Supercomputer! (1998)

Los Alamos National Laboratory and Caltech obtain gigaflops performance on parallel Linux machines running free software and built of commodity parts costing less than $55,000 each
A Novel Fundamental Frequency Estimator Based on Harmonic Pattern Match for Music Signals (2014)

The fundamental frequency (F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ) is an ubiquitous and crucial feature of music signals. However, due to nonstationary noise, missing harmonics, nonideal, i.e., Undesired, physical vibration of the musical instruments, etc., the estimation of F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> represents a considerable challenge when desiring to obtain robust and reliable results. In this paper, a novel harmonic pattern match (HPM) algorithm for F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> estimation of music signals is proposed to achieve improved performance. The novel HPM algorithm relies on the autocorrelation both in the time domain and in the frequency domain, exploiting the spectrum subset to guide the searching of F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> candidates (FCs), and an efficient mechanism to evaluate the match between each FC and the harmonic pattern of the input signal. The harmonic pattern of the measured spectrum is converted into a set of sub-pitches, which are extracted from the segmented sub bands. Finally, the estimated F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> is selected to best match the sub-pitches under a weighting strategy. Validation experiments were carried out using a database representation of musical instruments consisting of single pitched notes and the viability of the HPM algorithm was demonstrated to be competitive with several other F <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> estimators.