gebhart/patrepeval huggingface dataset:
Antidiabetic and antioxidative effects of Lepisanthes fruticosa fruit seed extractin type 2 diabetic experimental rats (2023)

Lepisanthes fruticosa (Roxb) Leenh or locally known as ceri Terengganu is an underutilised fruit species from the Sapindaceae family. The species was previously identified as a potent antioxidant source, but scientific information is still lacking and limited to in vitro. Therefore, the present study aimed to investigate the in vivo antidiabetic and antioxidative effects of L. fruticosa fruit seed extract (LFSE) in a high-fat diet, streptozotocin (HFD/STZ)-induced Sprague Dawley rats. After 8 weeks of HFD feeding, a low-dose STZ (35 mg/kg body weight) was injected to induce type 2 diabetes mellitus (T2DM). Two dosages of LFSE (300 and 600 mg/kg body weight) were orally administered to diabetic rats for 4 weeks. High dosage LFSE (600 mg/kg body weight) showed a more pronounced effect in anti-hyperglycemic activities as indicated by both sub-chronic and acute studies. The glucose-lowering ability of LFSE was supported by its improved serum insulin level (40%) as compared to diabetic control. LFSE (600 mg/kg) also resulted in a significant (P&lt;0.05) increase in superoxide dismutase (SOD) (20%) and catalase (CAT) (43%) activities, with a significant (P&lt;0.05) decrease in lipid peroxidation (28%) as compared to diabetic control. With regard to lipid profile, low dosage LFSE (300 mg/kg) led to a significant (P&lt;0.05) improvement in high-density lipoprotein cholesterol (HDL-c) (39%). Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of LFSE showed the presence of various phytochemicals with antidiabetic and antioxidant properties, with α-kojibiose, genistein-7,4'-di-O-β-D-glucoside and soyacerebroside II being the predominant ones. The findings may suggest that L. fruticosa fruit seed extract is potential in reducing hyperglycaemia and enhancing antioxidant status in HFD/STZ-induced diabetic rats. Therefore, it can be concluded that L. fruticosa fruit species may be considered as a promising candidate for a new and safe alternative remedy for the prevention and treatment of T2DM.
Exploring Building Data from Multispectral and Single-Photon Lidar Systems (2020)

This paper investigated building data from multispectral and single-photon Lidar systems. The multispectral datasets from the individual channels and fused channels were explored. The multispectral and single-photon Lidar data were compared across multiple aspects: the data acquisition geometry, number of echoes, intensity, density, resolution, data defects, noise level, and the absolute and relative accuracy. In addition, we explored the performance of the multispectral and single-photon data for roof plane detection for eight complex/stylish buildings to investigate the suitability of these data for 3D building reconstruction. The building data from the single-photon and multispectral Lidar systems were evaluated with respect to the reference building vector data with an accuracy of better than 5 cm. The advantages and disadvantages of both technologies and their applications in the urban building environment are discussed.
Transmission in vitro of hepatitis C virus from persistently infected human B-cells to hepatoma cells by cell-to-cell contact (2005)

Virus cell-to-cell spread has been reported for many different viruses and may contribute to pathogenesis of viral disease. The role played by cell-to-cell contact in hepatitis C virus (HCV) transmission was studied in vitro by cell co-cultivation experiments. A human lymphoblastoid B-cell line, infected persistently with HCV in vitro (TO.FE(HCV)), was used as HCV donor [Serafino et al., 2003]; recipient cells were the human hepatoma HepG2 cell line. Both cell types were co-cultured for 48 hr to allow the cell-to-cell contacts. The hepatoma HepG2 cells are not permissive to free-virus infection, but they were infected successfully using TO.FE(HCV) cells as source of virus. The kinetics of viral RNA synthesis and the percentage of infected cells were compared in cell-mediated-and cell-free-viral infection. After co-cultivation, a consistent proportion of hepatoma cells replicated HCV and stably expressed viral antigens. Virus produced was infectious as demonstrated by the ability to reinfect fresh B-cells. This cell model shows that permissiveness to HCV infection can be achieved in vitro in non-permissive hepatoma cells by direct cell-to-cell contacts with infected human B-cells. This mechanism of virus spread may also play a pathogenic role in vivo.
Regulating Valence States of Gold Nanocluster as a New Strategy for the Ultrasensitive Electrochemiluminescence Detection of Kanamycin (2021)

Monitoring of kanamycin residue has attracted considerable attention owing to the potential harm caused by the abuse of kanamycin. However, the detection of kanamycin has been limited owing to its electrochemical and optical inertness. Herein, we report a facile and highly efficient electrochemiluminescence (ECL) strategy for the detection of kanamycin based on the valence state effect of gold nanocluster (AuNC) probes. It is proven that Au<sup>0</sup> in chemically reduced AuNCs (CR-AuNCs) could be oxidized to Au<sup>I</sup> via the redox reaction between kanamycin and CR-AuNCs in the presence of H<sub>2</sub>O<sub>2</sub>, resulting in ECL quenching due to the valence state change of CR-AuNCs. Because the ECL of the AuNC probes is sensitively affected by the valence state, excellent sensitivity for kanamycin was achieved without any signal amplification operation and aptamers. A preferable linear-dependent curve was acquired in the detection range from 1.0 × 10<sup>-11</sup> to 3.3 × 10<sup>-5</sup> M with an extremely low detection limit of 1.5 × 10<sup>-12</sup> M. The proposed kanamycin sensing platform is very simple and shows high selectivity and an extremely broad linear range detection of kanamycin. Furthermore, the proposed sensing platform can detect kanamycin in milk samples with excellent recoveries. Therefore, this sensing strategy provides an effective and facile way to detect kanamycin and can help promote the understanding of the constructed mechanism of the AuNC-based ECL system, thus greatly broadening its potential application in ECL fields.
Metasurface-Based Tunable Reflector for Independent Control of Orthogonal Polarizations (2018)

This paper presents a metasurface reflector, characterized with a 0° reflection phase, which can be tuned to operate at any frequency within the band [1.1 - 1.7] GHz and in two orthogonal polarizations independently. The proposed metasurface, based on a double layer of periodic metallic patches and varactors, behaves like an artificial magnetic conductor (AMC). By varying the capacitance values of the varactors, the positions of the resonant frequencies of the AMC can be tuned in real time. The proposed solution offers the possibility to overcome the narrow band characteristics of AMC structures and to control the two orthogonal polarizations independently.
Motor unit recruitment strategies investigated by surface EMG variables (2002)

During isometric contractions of increasing strength, motor units (MUs) are recruited by the central nervous system in an orderly manner starting with the smallest, with muscle fibers that usually show the lowest conduction velocity (CV). Theory predicts that the higher the velocity of propagation of the action potential, the higher the power at high frequencies of the detected surface signal. These considerations suggest that the power spectral density of the surface detected electromyogram (EMG) signal may give indications about the MU recruitment process. The purpose of this paper is to investigate the potential and limitations of spectral analysis of the surface EMG signal as a technique for the investigation of muscle force control. The study is based on a simulation approach and on an experimental investigation of the properties of surface EMG signals detected from the biceps brachii during isometric linearly increasing torque contractions. Both simulation and experimental data indicate that volume conductor properties play an important role as confounding factors that may mask any relation between EMG spectral variables and estimated CV as a size principle parameter during ramp contractions. The correlation between spectral variables and CV is thus significantly lower when the MU pool is not stable than during constant-torque isometric contractions. Our results do not support the establishment of a general relationship between spectral EMG variables and torque or recruitment strategy.
CD40 and CD70 Co-Stimulate a Potent In Vivo Antitumor T Cell Response (1998)

In several studies, CD80, a potent co-stimulatory molecule, has been reported to be responsible for the induction of CD8+ antitumor T cell responses by CD80-transfected tumor cells. However, expression of CD80 by tumors not always ensures generation of a T cell-mediated antitumor response. Variables such as the inherent immunogenicity of a tumor and its major histocompatibility complex (MHC) expression status affect the efficacy of this approach. Therefore, in this study two other co-stimulatory ligands, CD40 and CD70, have been investigated for their ability to co-stimulate antitumor responses. The efficacy of CD40 and CD70 is compared with that of CD80, with respect to CD4 and CD8 T cell co-stimulatory capacity in vitro and their ability to induce in vivo antitumor responses. Furthermore, CD40 and CD70 are tested for their capacity to induce a long-lived memory response in vivo, as defined both by induction of tumor-specific cytotoxic T lymphocytes (CTLs) and rejection of wild-type tumor cells. It was found that, despite the fact that CD40 predominantly stimulates CD4 T cells, CD40-transfected MHC class II-negative P815 tumor cells become highly immunogenic and induce long-lasting memory tumor-specific CTLs in vivo. Furthermore, CD40 and CD70 emerge as powerful and even superior alternatives to CD80 for improving tumor immunogenicity in vivo. While the mechanisms by which they do so remain to be defined, these findings suggest additional strategies for immunotherapy.
Impact of charged species transport coefficients on self-bias voltage in an electrically asymmetric RF discharge (2018)

In this paper, we use a fluid model to simulate the excitation of a hydrogen radio-frequency discharge, and employ tailored voltage waveforms to assess the effect of charged species transport properties. Results of the fluid simulation are compared with experimental data and previous results obtained with a hybrid model. Several expressions for electron and ion transport coefficients are compared, and their impact on the self-bias potential is studied. The self-bias is shown to be insensitive to the choice of electron transport coefficients, while remarkably sensitive to variations in ion mobility. Besides, our results show that fluid models can be competitive with hybrid models, provided self-consistent ion transport models and rate constants are used.
Chemical Reactions in Supercritical Fluids. (1995)

Most homogeneous catalysts have higher selectivity but lower rates than heterogeneous catalysts in gas-phase reactions. An ideal catalyst would have the best of both worlds, high selectivity and high rates which may be possible with homogeneous catalysts in supercritical fluids rather than liquid solvents. These fluids are compressed gases heated past their critical point. Preliminary results have confirmed that increased rates and selectivities can be obtained because of several unusual properties of supercritical fluids: high solubility of reactant gases , rapid diffusion between phases, and possibly weaker solvation of the catalyst. This review will describe research on organic reactions and homogeneous catalysis in supercritical fluids, with emphasis on supercritical carbon dioxide and water as reaction media.
Thermométrie ultrasonore sur des géométries variables dans le temps. Application à la fabrication additive par fusion laser sur lit de poudre. (2022)

International audience
Experimental Investigation of Dynamic Delamination in Thick Polymeric Composite Laminates (1994)

Abstract In this work we present some preliminary results of optical experiments performed on dynamically deforming thick polymeric composite laminate plates. The composites used for this study are graphite-epoxy fiber reinforced composite plates, consisting of 48 plies (6mm inch thickness) in a quasi-isotropic arrangement. The plates are impact loaded in an out-of-plane configuration using a gas gun. Impact velocities are of the order of 1m/s to 30m/s. The lateral shearing interferometer of Coherent Gradient Sensing (CGS), in conjunction with high speed photography, is used to obtain real time interferograms of the out-of-plane deformation of the laminate. Both the elastic behavior of the laminate and the deformation following the onset of dynamic delamination are observed. Quantities such as the speed of delamination are measured and presented.
Mechanisms of Film Growth Rate Enhancement in Anodic and Cathodic Corona‐Discharge Oxiation Processes (1998)

Negative‐ and positive‐point corona discharge oxidation processes (anodic and cathodic cases, respectively), result in markedly different oxide thickness profiles. In the cathodic case, the enhancement varies in a complex manner over the entire wafer surface. The enhancement profiles are simulated using linear‐parabolic rate constants, modified to account for the corona current. Three enhancement factors are required for a reasonable fit. The interface reaction constant may be enhanced in both anodic and cathodic cases due to movement or emission of electrons. Effective oxidant concentration under the corona needle is hypothesized to be increased in the anodic case, and decreased in the cathodic case. Oxide fixed charge concentrations are much higher in the cathodic case and are potentially consistent with an electrochemical model of the oxidation rate enhancement.
In Vitro Models of Blood and Lymphatic Vessels—Connecting Tissues and Immunity (2022)

Blood and lymphatic vessels are regulators of physiological processes, including oxygenation and fluid transport. Both vessels are ubiquitous throughout the body and are critical for sustaining tissue homeostasis. The complexity of each vessel's processes has limited the understanding of exactly how the vessels maintain their functions. Both vessels have been shown to be involved in the pathogenesis of many diseases, including cancer metastasis, and it is crucial to probe further specific mechanisms involved. In vitro models are developed to better understand blood and lymphatic physiological functions and their mechanisms. In this review, blood and lymphatic in vitro model systems, including 2D and 3D designs made using Transwells, microfluidic devices, organoid cultures, and various other methods, are described. Models studying endothelial cell-extracellular matrix interactions, endothelial barrier properties, transendothelial transport and cell migration, lymph/angiogenesis, vascular inflammation, and endothelial-cancer cell interactions are particularly focused. While the field has made significant progress in modeling and understanding lymphatic and blood vasculature, more models that include coculture of multiple cell types, complex extracellular matrix, and 3D morphologies, particularly for models mimicking disease states, will help further the understanding of the role of blood and lymphatic vasculature in health and disease.
Design and fabrication of si-based photonic crystal stamps (2009)

In this work we report on the technology for enabling the mass replication of custom-designed and e-beam lithographically prepared structures via establishing UV-NIL nanoimprint processes for pattern transfer into UV curable pre-polymers. The new nano-fabrication technology based on the concept of disposal master technology (DMT) is suitable for mass volume manufacturing of large area arrays of sub-wavelength photonic elements. To show the potential of the application of the new nanoimprint technologies we choose as an example the fabrication of a photonic crystal (PhC) structure with integrated light coupling devices for low loss interconnection between PhC light wave circuits and optical fiber systems. We present two kinds of PhCs for fabrication of nanoimprint lithography stamps in Si. (a) A photonic crystal of Si-rods in air. This structure was fabricated with electron beam lithography (EBL) in resist and after lift-off, there is a mask of Cr on Si, then the pattern transfer into Si is performed using reacting ion etching (RIE) with SF6 as etch gas. We use 260 nm of positive resist (950K PMMA) for EBL exposure. Resist thickness, exposure dose, development time and parameters for etching have been optimized in this method. (b) In the second method lift-off was performed and metal mask was used as master. The subsequent steps for fabricating the master will be presented detail in our contribution.
Self‐assembly of Protein Nanoarrays on Block Copolymer Templates (2008)

Abstract There is considerable interest in developing functional protein arrays on the nanoscale for high‐throughput protein‐based array technology, and for the study of biomolecular and cell interactions at the physical scale of the biomolecules. To these ends, self‐assembly based techniques may be desirable for the nanopatterning of proteins on large sample areas without the use of lithography equipment. We present a fast, general approach for patterning proteins (and potentially other biomolecules) on the nanoscale, which takes advantage of the ability of block copolymers to self‐assemble into ordered surface nanopatterns with defined chemical heterogeneity. We demonstrate nanoarrays of immunoglobulin and bovine serum albumin on polystyrene‐block‐poly(methyl methacrylate) templates, and illustrate the applicability of our technique through immunoassays and DNA sensing performed on the protein nanoarrays. Furthermore, we show that the pattern formation mechanism is a nanoscale effect originating from a combination of fluid flow forces and geometric restrictions templated by an underlying nanopattern with a difference in protein adsorption behavior on adjacent, chemically distinct surfaces. This understanding may provide a framework for extending the patterning approach to other proteins and material systems.
Identification And Quantification Of Impurities Critical To The Performance Of Nitride Semiconductor Devices (2006)

Abstract not Available.
Effects of SCH 34826, an orally active inhibitor of atrial natriuretic peptide degradation, in healthy volunteers (1991)

Atrial natriuretic peptide is cleared from plasma by clearance receptors and by enzymatic degradation by way of a neutral metalloendopeptidase. Inhibition of neutral metalloendopeptidase activity appears to provide an interesting approach to interfere with metabolism of atrial natriuretic peptide to enhance the renal and haemodynamic effects of endogenous atrial natriuretic peptide. In this study, the effects of SCH 34826, a new orally active neutral metalloendopeptidase inhibitor, have been evaluated in a single-blind, placebo-controlled study involving eight healthy volunteers who had maintained a high sodium intake for 5 days. SCH 34826 had no effect on blood pressure or heart rate in these normotensive subjects. SCH 34826 promoted significant increases in excretion of urinary sodium, phosphate, and calcium. The cumulative 5-hour urinary sodium excretion was 15.7 +/- 7.3 mmol for the placebo and 22.9 +/- 5, 26.7 +/- 6 (p less than 0.05), and 30.9 +/- 6.8 mmol (p less than 0.01) for the 400, 800, and 1600 mg SCH 34826 doses, respectively. During the same time interval, the cumulative urinary phosphate excretion increased by 0.3 +/- 0.4 mmol after placebo and by 1.5 +/- 0.3 (p less than 0.01), 1.95 +/- 0.3 (p less than 0.01), and 2.4 +/- 0.4 mmol (p less than 0.001) after 400, 800, and 1600 mg SCH 34826, respectively. There was no change in diuresis or excretion of urinary potassium and uric acid. The natriuretic response to SCH 34826 occurred in the absence of any change in plasma atrial natriuretic peptide levels but was associated with a dose-dependent elevation of urinary atrial natriuretic peptide and cyclic guanosine monophosphate.(ABSTRACT TRUNCATED AT 250 WORDS)
Prenatal Rosiglitazone Administration to Neonatal Rat Pups Does Not Alter the Adult Metabolic Phenotype (2012)

Prenatally administered rosiglitazone (RGZ) is effective in enhancing lung maturity; however, its long-term safety remains unknown. This study aimed to determine the effects of prenatally administered RGZ on the metabolic phenotype of adult rats. Methods. Pregnant Sprague-Dawley rat dams were administered either placebo or RGZ at embryonic days 18 and 19. Between 12 and 20 weeks of age, the rats underwent glucose and insulin tolerance tests and de novo fatty acid synthesis assays. The lungs, liver, skeletal muscle, and fat tissue were processed by Western hybridization for peroxisome proliferator-activated receptor (PPAR)γ, adipose differentiation-related protein (ADRP), and surfactant proteins B (SPB) and C (SPC). Plasma was assayed for triglycerides, cholesterol, insulin, glucagon, and troponin-I levels. Lungs were also morphometrically analyzed. Results. Insulin and glucose challenges, de novo fatty acid synthesis, and all serum assays revealed no differences among all groups. Western hybridization for PPARγ, ADRP, SPB, and SPC in lung, liver, muscle, and fat tissue showed equal levels. Histologic analyses showed a similar number of alveoli and septal thickness in all experimental groups. Conclusions. When administered prenatally, RGZ does not affect long-term fetal programming and may be safe for enhancing fetal lung maturation.
Data from Polyamine Blocking Therapy Decreases Survival of Tumor-Infiltrating Immunosuppressive Myeloid Cells and Enhances the Antitumor Efficacy of PD-1 Blockade (2023)

&lt;div&gt;Abstract&lt;p&gt;Despite unprecedented advances in the treatment of cancer through the use of immune checkpoint blockade (ICB), responses are not universal and alternative strategies are needed to enhance responses to ICB. We have shown previously that a novel polyamine blocking therapy (PBT), consisting of cotreatment with α-difluoromethylornithine (DFMO) to block polyamine biosynthesis and a Trimer polyamine transport inhibitor, decreases myeloid-derived suppressor cells (MDSC) and M2-like tumor-associated macrophages (TAM). Both MDSCs and TAMs promote tumor progression, inhibit antitumor immunity, and limit the efficacy of ICB. In this study, we investigated the use of PBT to heighten therapeutic responses to PD-1 blockade in mice bearing 4T1 mammary carcinoma and B16F10 melanoma tumors. Whereas PBT inhibited primary tumor growth in both tumor models, 4T1 lung metastases were also dramatically decreased in mice treated with PBT. Reductions in MDSC and TAM subpopulations in 4T1 tumors from PBT-treated mice were accompanied by reduced cytoprotective autophagy only in tumor-infiltrating MDSC and macrophage subpopulations but not in the lung or spleen. PBT treatment blunted M2-like alternative activation of bone marrow–derived macrophages and reduced STAT3 activation in MDSC cultures while increasing the differentiation of CD80&lt;sup&gt;+&lt;/sup&gt;, CD11c&lt;sup&gt;+&lt;/sup&gt; macrophages. PBT significantly enhanced the antitumor efficacy of PD-1 blockade in both 4T1 and B16F10 tumors resistant to anti–PD-1 monotherapy, increasing tumor-specific cytotoxic T cells and survival of tumor-bearing animals beyond that with PBT or PD-1 blockade alone. Our results suggest that cotreatment with DFMO and the Trimer polyamine transport inhibitor may improve the therapeutic efficacy of immunotherapies in patients with cancer with resistant tumors.&lt;/p&gt;&lt;/div&gt;