gebhart/patrepeval huggingface dataset:
Inhibition of the formation of EETs and 20-HETE with 1-aminobenzotriazole attenuates pressure natriuresis (2004)

This study examined the effects of chronic blockade of the renal formation of epoxyeicosatrienoic acids and 20-hydroxyeicosatetraenoic acid with 1-aminobenzotriazole (ABT; 50 mg.kg(-1). day(-1) ip for 5 days) on pressure natriuresis and the inhibitory effects of elevations in renal perfusion pressure (RPP) on Na(+)-K(+)-ATPase activity and the distribution of the sodium/hydrogen exchanger (NHE)-3 in the proximal tubule of rats. In control rats (n = 15), sodium excretion rose from 2.3 +/- 0.4 to 19.4 +/- 1.8 microeq.min(-1).g kidney weight(-1) when RPP was increased from 114 +/- 1 to 156 +/- 2 mmHg. Fractional excretion of lithium rose from 28 +/- 3 to 43 +/- 3% of the filtered load. Chronic treatment of the rats with ABT for 5 days (n = 8) blunted the natriuretic response to elevations in RPP by 75% and attenuated the increase in fractional excretion of lithium by 45%. In vehicle-treated rats, renal Na(+)-K(+)-ATPase activity fell from 31 +/- 5 to 19 +/- 2 micromol P(i).mg protein(-1).h(-1) and NHE-3 protein was internalized from the brush border of the proximal tubule after an elevation in RPP. In contrast, Na(+)-K(+)-ATPase activity and the distribution of NHE-3 protein remained unaltered in rats treated with ABT. These results suggest that cytochrome P-450 metabolites of arachidonic acid contribute to pressure natriuresis by inhibiting Na(+)-K(+)-ATPase activity and promoting internalization of NHE-3 protein from the brush border of the proximal tubule.
Raman Lidar Measurements of Atmospheric Water Vapor: Development of a Daytime-Optimized System (1992)

This paper describes our research program on development of a Raman lidar system for measuring daytime profiles of atmospheric water vapor. The Raman lidar technique is a leading candidate for providing the high-resolution, day-night profiling of water vapor that is critical to programs in global climate change research. Because of the crucial role that water vapor plays directly in the earth’s radiation budget as an absorber, as well as its role in cloud formation and optical phenomenology, accurate, three-dimensional measurements of water-vapor concentration are an essential part of the experimental capability that is anticipated to be required for climate-change research.
Characterization of Granular Systems by Digital Signal Processing of Low Strain Wave Response (1996)

The characterization and quality assessment of composite materials, particularly those constructed of residual materials such as slags, ashes, and crumb rubber, are difficult because of chemical and physical inhomogeneity and inconsistency at the time of their production. The characterization of granular systems, constructed of a mixture of geological and residual materials, may provide inconclusive information when tested by existing methods. The proposed nondestructive evaluation uses low-strain, low-frequency dynamic excitation as a means to better evaluate such materials. The applied excitation results in a sample response characterized by wave patterns. The wave pattern response is analyzed by digital signal processing and an artificial neural networks (ANN) system to facilitate characterization of the material. Dynamic excitation of representative samples was accomplished using a longitudinal-torsional resonant column. Nondestructive testing was conducted at low strain levels applying a torsional oscillatory motion. The resulting sample response wave forms were recorded. The shear modulus values obtained at the resonant frequency of each sample were used to train an ANN system to characterize sample wave responses measured at random frequencies. The recorded sample response wave forms were analyzed to identify the embedded dominant frequencies, which were unique signatures of the tested materials. These signatures were then submitted to the previously trained ANN to predict the material shear modulus. The samples tested were composed of dry Ottawa sand (0.85 to 0.6 mm), Ottawa sand and crumb rubber modifier, and soda-lime spheres compacted at various densities and tested under different confining pressures. Distinctive patterns, unique to the granular sample composition, were obtained. These are termed the signature patterns. A fast Fourier transform algorithm was used to convert collected data to the frequency domain. ANN analysis was applied to enhance pattern recognition and characterize the samples according to their shear moduli
ChemInform Abstract: Copper(I)‐Catalyzed Regio‐ and Chemoselective Single and Double Addition of Nucleophilic Silicon to Propargylic Chlorides and Phosphates. (2012)

Abstract Treatment of linear propargylic chlorides and phosphates with equimolar amounts of Zn agents (II) and (IX) allows an efficient and regioselective formation of silylated allenes.
Relationships Among Resistances to Fusarium and Aspergillus Ear Rots and Contamination by Fumonisin and Aflatoxin in Maize (2007)

ABSTRACT Fusarium verticillioides, F. proliferatum, and Aspergillus flavus cause ear rots of maize and contaminate the grain with mycotoxins (fumonisin or aflatoxin). The objective of this study was to investigate the relationships between resistance to Fusarium and Aspergillus ear rots and fumonisin and aflatoxin contamination. Based on a previous study of 143 recombinant inbred lines from the cross NC300 x B104, 24 lines with the highest and 24 lines with the lowest mean fumonisin concentration were selected for further evaluation. Paired plots of each line were inoculated with F. verticillioides and F. proliferatum or with A. flavus in replicated trials in 2004 and 2005 in Clayton, NC, and College Station, TX. The low-fumonisin group had significantly lower levels of fumonisin, aflatoxin, and Fusarium and Aspergillus ear rots. Across year-location environments, all four traits were significantly correlated; the genotypic correlation (r(G)) ranged from r(G) = 0.88 (aflatoxin and Aspergillus ear rot) to r(G) = 0.99 (Fusarium and Aspergillus ear rots). Quantitative trait loci (QTLs) were identified and their effects estimated. Two QTLs affected both toxin concentrations, one QTL affected both ear rots, and one QTL affected Aspergillus and Fusarium rots and fumonisin. These results suggest that at least some of the genes involved in resistance to ear rots and mycotoxin contamination are identical or genetically linked.
Directional functions for orientation distribution estimation (2008)

We propose a novel method to obtain the orientation distribution function (ODF) from diffusion weighted signals measured using the Q-ball imaging methodology. Past work has involved using the spherical harmonics or radial basis functions to represent the ODF. In this work, we propose a novel function that has the ability to compactly represent signals measured using high angular resolution diffusion imaging (HARDI). Further, the closed form solution for computing the corresponding ODF turns out to be the Watson distribution used in directional statistics. As a special case, we formulate a directional function for which the ODF is the von Mises-Fisher (vMF) distribution. Experiments on some synthetic data show the robustness of the proposed method to represent ODF's in the presence of noise. We also compare the method with ODF estimation using spherical harmonics and show some of its advantages.
Repeated exposure to aerosolized brevetoxin-3 induces prolonged airway hyperresponsiveness and lung inflammation in sheep (2011)

Repeated exposures to PbTx-3 result in prolonged AHR and lung inflammation. These pathophysiologic responses could be underlying contributors to the prolonged respiratory symptoms in humans after red tides.
Advancements in Toxicity Testing Applied to Design and Control of Biological Processes (1991)

Toxicity testing is an essential tool for assessing the effects of, and fate of, many low-concentration toxicants in wastewater treatment systems. Toxicity testing can be divided into two parts: diagnostic toxicology evaluates the toxicity of a contaminant, effluent, or process, and toxicological engineering bases engineering design on the removal or production of toxicity. This paper presents six recent advancements in diagnostic toxicology and toxicological engineering identified by members of the Specialty Group on Hazard Assessment and Control of Environmental Contaminants. They are: (1) an ecological framework for applying toxicity testing, (2) biological early warning systems for on-line detection of toxic inputs, (3) inplant testing to detect and mitigate a toxic upset, (4) methods for rapid and cost-effective detection of genotoxins, (5) an approach for determining what discharged component must be controlled to eliminate an ecosystem disturbance, and (6) an application of process kinetics to design biological processes that are resistant to toxic upsets.
Abstract 5447: Gene expression of circulating tumor cells is predictive of treatment response in patients with advanced prostate cancer (2020)

Abstract Background: Genome and transcriptome-based analysis has begun to reshape the approach to prostate cancer (PC). Two different gene expression signatures have shown that PC can be divided into 3 subclasses reflecting luminal-basal biology. These subtypes point toward biological drivers that may strongly influence how care should be personalized including optimization of androgen receptor targeted therapy. The majority of work done in this area has been based on tissue-based gene expression. With the advent of newer nanotechnology platforms for isolation of circulating tumor cells (CTCs), profiling of PC gene expression from blood is now possible. Methods: We recruited 34 patients with metastatic castration resistant PC who had available blood specimens prior to initiation of androgen receptor signaling inhibitor (ARSI, e.g. abiraterone, enzalutamide and apalutamide) therapy. We combined variations of the NanoVelcro Assays (thermoresponsive, click-chemistry) allowing for capture and release of CTCs with intact mRNA. Gene sets from the PCS and PAM50 signatures were re-reviewed to optimize signal detection in the blood and enriched for genes upregulated in PC. The NanoString nCounter platform was applied to profile the resulting genes. A pilot study was conducted using banked samples available through the Urologic Oncology Program Blood and Biospecimen Bank at Cedars-Sinai Medical Center. Results: The final assay was tested in banked blood samples and provided classifications of patients that associated with clinical responsiveness to therapy. Validation was conducted to examine the performance of the CTC-specific PCS/PAM50 panel in public databases (including Prostate Cancer Transcriptome Atlas and GenomeDx). Our pilot study showed that the median overall survival was significantly worse in PCS1 patients. Conclusions: This study shows initial proof of principle that genomic classification in blood is possible using contemporary tool for blood component isolation and RNA profiling. Additional technical and clinical validations are needed prior to widespread implementation, but these methods may make it possible to increase the utilization of genomic classifiers in clinical studies and in practice. Citation Format: PAI-CHI TENG, Minhyung Kim, Yu Jen Jan, Jie-Fu Chen, Nu Yao, Gina C. Chu, Pin-Jung Chen, Jasmine J. Wang, Yi-Te Lee, Yazhen Zhu, Leland W. Chung, Felix Y. Feng, Michael R. Freeman, Sungyong You, Hsian-Rong Tseng, Edwin M. Posadas. Gene expression of circulating tumor cells is predictive of treatment response in patients with advanced prostate cancer [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 5447.
Monitoring the oxidative stability of virgin coconut oil during oven test using chemical indexes and FTIR spectroscopy. (2011)

To investigate the role of myo-inositol under hypertonic conditions, we examined the effects of inhibition of myo-inositol transport in Madin-Darby canine kidney (MDCK) cells using an analog of myo-inositol, 2-O,C-methylene-myo-inositol (MMI). We first characterized the inhibitory effects of MMI on myo-inositol transport in MDCK cells. The Na+-dependent component of [3H] myo-inositol uptake was inhibited by MMI in a concentration-dependent manner, although MMI did not inhibit the activities of the betaine transporter and system A neutral amino acid transporter. We found decreased affinity for myo-inositol in the presence of MMI, whereas the maximal velocity (Vmax) of the transporter did not change. Thus MMI behaves as a competitive inhibitor of myo-inositol transport with a relatively high inhibition constant (K(i)) value (1.6 mM). Myo-inositol content in hypertonic MDCK cells was markedly reduced in the presence of 5 mM MMI, but MMI itself did not accumulate in these cells. The hypertonic cells began to detach in the presence of MMI 3 days after increasing medium osmolality, whereas MMI did not affect the cells in isotonic medium. We also examined the effects of MMI on colony-forming efficiency of MDCK cells. MMI decreased colony-forming efficiency in a concentration-dependent manner, and addition of myo-inositol returned the efficiency to the value without MMI. Addition of betaine also increased colony-forming efficiency in the presence of MMI. These results indicate that myo-inositol plays an important role in survival and growth under hypertonic environment.
Von Willebrand Factor, ADAMTS13 and D-Dimer Are Correlated with Different Levels of Nephropathy in Type 1 Diabetes Mellitus (2015)

We have investigated whether von Willebrand factor, ADAMTS13 (a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13), and D-Dimer were associated with different levels of renal function in patients with type 1 diabetes. Patients were classified according to level of renal function through estimated glomerular filtration rate: ≥90 and <130mL/min/1,73m2, n=52 (control group), ≥60 and <90mL/min/1,73m2, n=29 (mild renal dysfunction group), <60mL/min/1,73m2, n=28 (severe renal dysfunction group); and through urinary albumin excretion: normoalbuminuria, microalbuminuria and macroalbuminuria. Von Willebrand factor, ADAMTS13, and D-Dimer plasma levels were determined by enzyme-linked immunosorbent assay. ADAMTS13 activity was determined by fluorescence resonance energy transfer assay. Von Willebrand factor levels were increased in patients with mild (P=0.001) and severe (P<0.001) renal dysfunction as compared to the control group. ADAMTS13 levels were also increased in mild (P=0.029) and severe (P=0.002) renal dysfunction groups in comparison to the control group, while ADAMTS13 activity was increased only in the severe renal dysfunction group as compared to the control group (P=0.006). No significant differences were observed among the groups regarding von Willebrand factor/ADAMTS13 ratio. ADAMTS13 activity/ADAMTS13 levels ratio was reduced in patients with mild (P=0.013) and severe (P=0.015) renal dysfunction as compared to the control group. D-Dimer levels were increased in patients with mild (P=0.006) and severe (P<0.001) renal dysfunction as compared to the control group; it was also higher in patients with severe renal dysfunction as compared to the mild renal dysfunction group (P=0.019). Similar results were found for albuminuria classification. Increased von Willebrand factor, ADAMTS13, and D-Dimer levels and decreased ADAMTS13 activity/ADAMTS13 levels ratio are associated with renal dysfunction in patients with type 1 diabetes, suggesting that endothelial dysfunction and hypercoagulability are associated with nephropathy in type 1 diabetes.
The Nuclear Receptor Superfamily: A Personal Retrospect on the First Two Decades (2005)

International audience
Comparison of validated HPLC methods using two derivatizing agents for gamma-aminobutyric acid quantification (2016)

Objective: The purpose of this study was to validate and compare two HPLC analyses of GABA after derivatization with 2-hydroxynaphthaldehyde (HN) or with o-phthaladehyde (OPA) and 3-mercaptopropionic acid (MPA) in terms of reproducibility, sensitivity and stability of two derivatives.Materials and Methods: GABA was derivatized with either 2-hydroxynaphthaldehyde (HN) or with o-phthaladehyde (OPA) and 3-mercaptopropionic acid (MPA) and was analyzed and validated using two different HPLC methods.Results: Reliability resulted in satisfaction for the HPLC methods in each derivatizing agent.Linear correlation was obtained in the concentration ranges of 40-600 g/ml and 0.2-0.9g/ml for GABA-HN and GABA-OPA/MPA, respectively.The low limit of detection (LOD) and the limit of quantification (LOQ) of GABA-HN were 1 g/ml and 5 g/ml while LOD and LOQ of GABA-OPA/MPA were 0.004 g/ml and 0.02 g/ml.Validation results of two methods with chosen derivatizing agents showed that the methods were reproducible and precise on quantification of GABA.The method with GABA-OPA/MPA derivatization revealed higher sensitivity compared to one with GABA-HN derivatization.However, GABA-OPA/MPA derivative was less stable.Conclusion: Both validated methods could be used for sensitive and accurate analysis of GABA.
ChemInform Abstract: Indium‐Mediated Facile Dehydration and Beckmann Rearrangement of Oximes. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
1764-P: Insulin Sensitive Induction of Adipogenesis (2019)

Healthy adipose tissue has a remarkable ability to adapt to energy intake through contraction and expansion. A large body of evidence pin-points the ability expand adipose tissue as vital to maintain whole body lipid homeostasis and insulin sensitivity in humans as well as in mice. Increases in fat mass can be driven by expansion of existing adipocytes or by recruitment of new adipocytes from adipose tissue pre-courser cells or preadipocytes (Adipogenesis). Failure to expand adipose tissues as well as appearance of dysfunctional large adipocytes both result in local and systemic insulin resistance. Conversely, strategies to preserve adipocyte function during tissue expansion through enhanced adipogenesis could preserve insulin function in the face of obesity or high caloric intake. In order to study the hormonal control of adipose tissue expansion we have examined the ability of insulin and IGF-1 to induce adipogenesis in isolated rodent primary SVF cells. We find that both insulin and IGF-1 dose dependently induce lipid droplet accumulation and expression of adipocyte genes in primary cells isolated from mouse epididymal and subcutaneous adipose depots. Surprisingly, adipogenesis in mouse SVF cells is a very insulin sensitive process and more specifically we identify CD45neg/Ly6c low SVF cells isolated from epididymal fat pads as extremely sensitive to insulin induced adipogenesis. These results indicate that insulin signaling directly in preadipocytes could drive adipocyte differentiation in vivo e.g., during high insulin levels in serum in response to prolonged periods of high caloric intake or lipid induced insulin resistance. Disclosure T.Å. Pedersen: Employee; Spouse/Partner; Cook Medical. Employee; Self; Novo Nordisk A/S. J. Peics: Employee; Self; Novo Nordisk A/S. G.S. Olsen: Employee; Self; Novo Nordisk A/S.
Spin frustration and concealed asymmetry: structure and magnetic spectrum of [Fe3O(O2CPh)6(py)3]ClO4·py † (2001)

The oxo-centred trinuclear complex [Fe3O(O2CPh)6(py)3]ClO4·py and its fully deuteriated analogue have been synthesized. X-Ray crystallography at T = 233 K shows that the complex has threefold symmetry, space group P63/m. Incoherent inelastic neutron scattering spectra at T = 1.5 K however show the presence of two inequivalent sets of molecules, one a static “isosceles” coupled system, with two J values for the three metal–metal interactions, the other a dynamic system, with rapid pseudorotation between equivalent isosceles geometries. Combining infrared and neutron scattering data, the distortion of the cluster has been estimated.
The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy (2020)

The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims on the precision of SUV measurements. First, tumor glycolytic activity as reflected by the maximum SUV (SUV<sub>max</sub>) is measurable from FDG PET/CT with a within-subject coefficient of variation of 10%-12%. Second, a measured increase in SUV<sub>max</sub> of 39% or more, or a decrease of 28% or more, indicates that a true change has occurred with 95% confidence. Two applicable use cases are clinical trials and following individual patients in clinical practice. Other components of the Profile address the protocols and conformance standards considered necessary to achieve the performance claim. The Profile is intended for use by a broad audience; applications can range from discovery science through clinical trials to clinical practice. The goal of this report is to provide a rationale and overview of the FDG PET/CT Profile claims as well as its context, and to outline future needs and potential developments.
Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis (2016)

The data suggest that IGF-I is modulated distinctly in different clinical forms of tegumentary leishmaniasis. IGF-I seemingly exerts effect on parasite growth likely contributing to its persistence in the skin in earlier phase. In addition the decreased IGF-I serum levels may affect the modulation of inflammation and lesion healing in chronic phase. In view of potential role of IGF-I in the pathogenesis of ATL we can speculate on therapeutic procedures taking into account the local IGF-I level.
Preoperative prediction of vestibular schwannoma's nerve of origin with posturography and electronystagmography (2010)

Hearing loss due to surgery was significantly lower in patients with tumors from the SVN than from the IVN (p = 0.011). Pathologic results in preoperative ENG (p < 0.0001) and CDPP (p = 0.025) were significantly more frequent in subjects with SVN than with IVN schwannomas.
The Only Constant is Change: New ICD-10 Codes in Neonatology (2021)

The philosopher Heraclitus stated, "the only constant in life Is change."With nearly 30 years of experience as a neonatologist and 45 years within the hospital setting, Heraclitus' adage holds true when considering healthcare.Advances in knowledge surrounding technology, genetics, diagnostic evaluations, and therapeutic interventions remain at the forefront in the practice of most clinicians."51 NEONATOLOGY TODAYtwww.NeonatologyToday.nettOctober2021