gebhart/patrepeval huggingface dataset:
Multiphase Control for Robust and Complete Soft-charging Operation of Dual Inductor Hybrid Converter (2019)

This paper presents a new Multiphase Dual Inductor Hybrid (MP-DIH) Converter for application in data center and telecommunication systems. The converter is based on addition of two output filter inductors to a Dickson switched-capacitor converter. The inductors are operated in multiple phases that are non-overlapped and evenly distributed over one switching cycle, completely soft-charging all flying capacitors even in the presence of practical capacitor mismatches and voltage ripples. In this converter operation, each branch of the switched-capacitor network is activated individually in one charging phase, and two interleaved inductors are employed to softly charge and discharge the capacitors to achieve high efficiency without any complex capacitor sizing or split phase operation. To verify the topology and its soft-charging advantages, a 48V-to-1.8V 20W experimental converter prototype is constructed. The converter achieves 92.4% peak efficiency for 40V-to-1.8V conversion and 92.1% peak efficiency for 48V-to-1.8V conversion at 4A load, and with 20% capacitance variations.
13C Hyperfine Interaction in the Triplet State of C60: An Electron Spin Echo Envelope Modulation Study. Eds. H. Kuzmany, J. Fink, M. Mehring, S. Roth. (1995)

The metastable triplet state of C60 molecules in frozen toluene solution was investigated by pulsed EPR after laser flash excitation. The non-icosahedral symmetry of the wavefunction shows up in the triplet finestructure parameters |D|, |E| &gt;0 [1]. 13C hyperfine interaction in isotopically enriched material was measured by one- and two-dimensional ESEEM experiments. The observed modulation patterns are best represented by a model calculation assuming a spin density maximum near the equatorial plane of the molecule with respect to the D5d symmetry axis. As a consequence the D parameter must be positive.
Containerized Strawberry Transplants Reduce Establishment-period Water Use and Enhance Early Growth and Flowering Compared with Bare-root Plants (2006)

Experiments were conducted in two seasons in Dover, Fla. (central Florida), with bare-root and containerized (plug) strawberry ( Fragaria × ananassa ) transplants to evaluate transplant establishment-period water use, plant growth, and flowering responses in the 3-week transplant establishment period. Strawberry plug plants were established with 290 gal/acre water applied only with the transplant at planting time, while 200,000 gal/acre from microjet or 1 million gal/acre of water from sprinkler irrigation were used to establish bare-root transplants. Root, shoot, and crown dry matter of plug plants rapidly increased during the establishment period, while there was a decline in leaf area and root and crown mass of bare-root plants, even with sprinkler or microjet irrigation. Water applied with the bare-root transplant only at planting was not enough to keep the plant alive during the establishment period. Large plug plants, but not irrigated bare-root plants, began flowering at 3 weeks after planting. Plug plants were used to successfully establish strawberry crops with low water inputs.
On acquisition of high-quality video from unmanned vehicles (2015)

Unmanned ground and air vehicles are increasingly used for various applications such as area surveillance, security, geographical mapping, etc. In most applications, an important factor limiting their performance is the quality of images transmitted from the vehicle. We discuss options and current limitations for elements in the video and sensor data transmission chain and summarize our experimental evaluation of beyond-high-definition video acquisition from an unmanned vehicle.
In-situ ellipsometry: applications to thin film research, development, and production (1999)

Many industries including the optics industry, semiconductor industry, and magnetic storage industry are deeply rooted in the science and technology of thin film materials and thin film based devices. Research in novel thin film systems and the engineering of artificial structures increasingly requires a control on the atomic scale in both thickness and lateral order. Development of the deposition and fabrication processes for these thin film structures requires technical sophistication and efficiency combined with an understanding of the multi-faceted process interactions. The production of these materials necessitates a remarkable degree of control to minimize scrap and assure good performance. Furthermore, in today’s industry these operations must occur at an ever accelerating pace. In this article, we will review one technique which can make these challenges more tractable - insitu ellipsometry. This is a very powerful tool which is capable of characterizing thin film processes in real-time. We review the art and illustrate with novel applications to metal thin film growth. In addition, we will illustrate how information obtained with insitu ellipsometry can predict the end use thin film properties such as the transport properties. In conclusion, further advances in insitu ellipsometry and its applications will be discussed in terms of needs and trends as a tool for thin film research, development and production.
Analysis acceleration in the design of frequency selective surfaces using parametric techniques (2007)

The design of multi-layer frequency selective surfaces often requires characterising the behaviour of the structure in wide frequency and angle ranges. Moreover, a fine tuning of the design leads to a large parameter space and results in a long computational time. To address this problem, an efficient parameterisation and interpolation technique has been implemented within the multimode equivalent network approach based on the integral equation formulation, a technique developed for the analysis of multi-layer periodic structures. The paper describes this technique and shows for a test case consisting of an array integrated with an FSS how the calculation time can be drastically reduced.
HEREDITARY FIBRINOGEN A A ALPHA-CHAIN AMYLOIDOSIS; PHENOTYPIC CHARACTERIZATION AND THE ROLE OF LIVER TRANSPLANTATION (2008)

Heaton, N D.; O'Grady, J; Rela, M; Portmann, B; Wendon, J; Hendry, B; Buxton-Thomas, M; Banner, N; Benson, M; Stangou, A J. Author Information
Major hemolymph protein of <i>Aedes aegypti</i> larvae (1997)

Aedes aegypti larval hemolymph proteins were analyzed, and the major protein was characterized. The major protein, designated P1, is hexameric and is composed of subunits with molecular weights estimated to be 83,000. P1 is dissociated into its subunits when the pH is elevated from 7 to 9. This protein accumulates during the last larval instar and is not detected in adult mosquitoes. These characteristics, together with the high content of aromatic amino acids, include P1 in the arylphorin group of the insect storage proteins. Arch. Insect Biochem. Physiol. 34:191–201, 1997. © 1997 Wiley-Liss, Inc.
Design optimization of highly efficient spectrum-splitting and beam-concentrating diffractive optical element for lateral multijunction solar cells (2014)

Two improved algorithms are proposed to extend a diffractive optical element (DOE) to work under the broad spectrum of sunlight. An optimum design has been found for the DOE, with a weighted average optical efficiency of about 6.8% better than that of the previous design. The optimization of designing high optical efficiency DOEs will pave the way for future designs of high-efficiency, low-cost lateral multijunction solar cells based on such a DOE.
Pain and allodynia/hyperalgesia induced by intramuscular injection of serotonin in patients with fibromyalgia and healthy individuals (2000)

The aim of this study was to investigate the effect of injection of serotonin (5-HT) into the masseter muscle on pain and allodynia/hyperalgesia. Twelve female patients with fibromyalgia (FM) and 12 age-matched female healthy individuals (HI) participated in the study. The current pain intensity (CPI) and the pressure pain threshold (PPT) of the superficial masseter muscles were assessed bilaterally. 5-HT in one of three randomized concentrations (10(-3), 10(-5), 10(-7) M) or isotonic saline was then injected into either of the two masseter muscles in a double-blind manner. After the injections the CPI and PPT were recorded ten times during 30 min. The injections were repeated twice with the other concentrations of 5-HT after 1 and 2 weeks, respectively. In the FM-group there was a non-significant increase of CPI after injection that lasted during the entire 30-min period irrespective of whether 5-HT or saline was injected. Neither did the PPT change significantly. In the HI-group pain developed significantly after injection irrespective of whether 5-HT or saline was injected, but significantly more so after 5-HT at 10(-3) M than saline injection. CPI decreased quickly and then remained on a very low level for most of the experiment. 5-HT at both 10(-5) M and 10(-3) M caused a significantly greater decrease of PPT than saline. In conclusion, our results show that 5-HT injected into the masseter muscle of healthy female subjects elicits pain and allodynia/hyperalgesia, while no such responses occur in patients with fibromyalgia.
The Generalized Degrees of Freedom Region of the MIMO Z-Interference Channel With Delayed CSIT (2017)

The generalized degrees of freedom (GDoF) region of the multiple-input multiple-output (MIMO) Gaussian Z-interference channel with an arbitrary number of antennas at each node is established under the assumption of delayed channel state information at transmitters (CSIT). The GDoF region is parameterized by α, which links the interference-to-noise ratio (INR) to the signal-to-noise ratio (SNR) via INR = SNRα. A new outer bound for the GDoF region is established by maximizing a bound on the weighted sum-rate of the two users, which in turn is obtained by using a combination of genie-aided side-information and an extremal inequality. The maximum weighted sum-rate in the high SNR regime is shown to occur when the transmission covariance matrix of the interfering transmitter has full rank. An achievability scheme based on block-Markov encoding and backward decoding is developed which uses interference quantization and digital multicasting to take advantage of the channel statistics of the cross-link, and the scheme is separately shown to be GDoF-optimal in both the weak (α ≤ 1) and strong (α > 1) interference regimes. This is the first complete characterization of the GDoF region of any interference network with delayed CSIT, as well as the first such GDoF characterization of a MIMO network with delayed CSIT and arbitrary number of antennas at each node. For all antenna tuples, the GDoF region is shown to be equal to or larger than the degrees of freedom (DoF) region over the entire range of α, which leads to a V-shaped maximum sum-GDoF as a function of α, with the minimum occurring at α = 1. The delayed CSIT GDoF region and the sum-DoF are compared with their counterparts under perfect CSIT, thereby characterizing all antenna tuples and ranges of α for which delayed CSIT is sufficient to achieve the perfect CSIT GDoF region (or sum-DoF). It is also shown that treating interference as noise is not, in general, GDoF-optimal for the MIMO Z-IC, even in the weak interference regime.
A 3D Unsteady Analysis of a Wells Turbine in a Sea-Wave Energy Conversion Device (2003)

A Wells turbine designed for power generation in an innovative OWC (Oscillating Water Column) device for sea-wave energy conversion is investigated. This work aims to predict the turbine performance under a continuously variable reciprocating flow due to the action of the sea waves. When the amplitude of the oscillating flow reaches high values, stall occurs around the blades with a drop in the turbine performance. CFD simulation has been carried out aiming to provide an insight of flow behavior over the blades approaching these large amplitude flow conditions. Three test cases, preliminarily examined in order to assess the capability of the numerical methods, are presented and discussed: the first test-case concerns the 2D unsteady turbulent flow past a symmetrical airfoil undergoing oscillating pitching motion; the second test case concerns the 3D analysis of a high solidity Wells turbine in presence of different constant axial fluxes; the third test case concerns the 3D analysis of a high solidity Wells turbine in presence of an oscillating axial flux. Finally the flow past the low solidity Wells turbine rotor is simulated. The analysis has been performed by considering the flow to be unsteady, incompressible and viscous, while turbulence was modeled using the one-equation Spalart Allmaras model or the two-equations k-ω model.
Abstract 167: Collateral Flow and ASPECTS of Infarct Evolution Dominate Time to Reperfusion in Outcomes of TREVO2 (2013)

Background: Definitive reperfusion, or revascularization associated with good clinical outcomes, is likely dependent on key imaging variables. ASPECTS score on imaging before and after revascularization may chronicle the extent of ischemic injury in acute stroke. We hypothesized that ASPECTS and other key imaging variables would be associated with clinical outcome after endovascular therapy in the TREVO2 trial. Methods: TREVO2 utilized independent core labs for CT/MRI and angiography central review. Retrospective review of ASPECTS by expert consensus on baseline and 24 hour imaging was conducted in anterior circulation cases, blinded to all other data. Univariate and multivariate analyses determined the impact of key imaging variables (baseline ASPECTS, ASPECTS ≥ 8, collaterals, time to TICI 2a reperfusion or greater, final TICI, 24-hour ASPECTS) on good clinical outcome (mRS 0-2) and mortality at day 90. Results: 166/177 cases in TREVO2 were anterior circulation occlusions. Baseline ASPECTS was ≤ 7 in 83/166 (50%) cases. Baseline ASPECTS score ≤ 7 was unrelated to age, gender, or any other clinical parameter other than NIHSS score (median 19 (17-23) vs. 17 (13-20) for ASPECTS &gt; 7, p&lt;0.001) and clot location (more ICA than M2 occlusions, p=0.044). Baseline ASPECTS ≤ 7 was also unrelated to post-device TICI or post-procedure SICH. Baseline ASPECTS ≤ 7 was associated with asymptomatic hemorrhage at 24 hours (63.9% vs. 37.3%, p=0.001), 90-day mortality (35.4% vs. 19.3%, p=0.024), and less frequent good clinical outcome (21.5% vs. 42.0%, p=0.007). Univariate imaging predictors of good clinical outcome at day 90 included baseline ASPECTS (OR 1.82, p&lt;0.001), baseline ASPECTS ≥ 8 (OR 2.64, p=0.006), collateral grade (OR 1.85, p=0.003), post-procedure TICI (OR 2.11, p&lt;0.001), 24-hour ASPECTS (OR 1.67, p&lt;0.001) and 24-hour ASPECTS ≥ 8 (OR 4.38, p&lt;0.001). Time to TICI 2a or greater was not predictive. Multivariate analyses showed that 24-hour ASPECTS (OR 1.70, p&lt;0.001) and post-procedure TICI (OR 2.49, p=0.003) best predicted good outcome. Conclusions: Better ASPECTS (≥ 8), collaterals, and reperfusion are strongly associated with good clinical outcome whereas the large proportion (50%) of TREVO2 cases with baseline ASPECTS ≤ 7 likely influenced mortality.
La densité urbaine permet-elle de favoriser une mobilité plus durable ? (2017)

LASUR
IL-4 inhibits the expression of high affinity IL-2 receptors on monoclonal human B cells. (1990)

In the presence of anti-mu antibodies (anti-microAb), monoclonal B lymphocytes from patients suffering from B type chronic lymphocytic leukemia (B-CLL) can respond to IL-2. In contrast to the effect it exerts on normal B cells, IL-4 does not promote DNA synthesis by B-CLL lymphocytes. Rather this interleukin inhibits the response to IL-2 in all patients' cells that responded to this interleukin. We thus examined whether IL-4 would modulate the number and/or the affinity of IL-2 receptors. A 3-day activation of cells by anti-microAb induced a few hundred high affinity IL-2 receptors (HA-IL-2R) on B-CLL cell surface, as determined by Scatchard analysis. Treatment of cells with IL-4 caused a marked decrease in the number of HA-IL-2R without interfering with the binding ability of IL-2. In contrast with this profound suppressive effect, IL-4 did not down-regulate the expression of each chain, alpha and beta (p55 and p75, respectively), of the HA-IL-2R heterodimer. In fact, the expression of alpha and beta induced by anti-microAb was enhanced by IL-4. Altogether, IL-4 exerts a critical influence on the function and the configuration of HA-IL-2R without inhibiting the expression of two subunits, alpha and beta.
Catecholaminergic cell type-specific expression of Cre recombinase in knock-in transgenic rats generated by the <i>Combi</i> -CRISPR technology (2022)

ABSTRACT Background Cell groups containing catecholamines provide a useful model to study the molecular and cellular mechanisms underlying the morphogenesis, physiology, and pathology of the central nervous system. For this purpose, it is necessary to establish a system to induce catecholaminergic group-specific expression of Cre recombinase. Recently, we introduced a gene cassette encoding 2A peptide fused to Cre recombinase into the site between the C-terminus and translational termination codons of the rat tyrosine hydroxylase (TH) open reading frame by the Combi -CRISPR technology, which is a genomic editing method to enable an efficient knock-in (KI) of long DNA sequence into a target site. However, the expression patterns of the transgene and its function as well as the effect of the mutation on the biochemical and behavioral phenotypes in the KI strains have not been characterized yet. New Method We aimed to evaluate the usefulness of TH-Cre KI rats as an experimental model for investigating the structure and function of catecholaminergic neurons in the brain. Results We detected cell type-specific expression of Cre recombinase and site-specific recombination activity in the representative catecholaminergic groups in the TH-Cre KI rat strains. In addition, we measured TH expression level and catecholamine accumulation in the brain regions, and spontaneous locomotion, indicating that catecholamine metabolism and general behavior are apparently normal in these KI rats. Conclusions TH-Cre KI rat strains produced by the Combi -CRISPR system offer a beneficial model to study the molecular and cellular mechanics for the morphogenesis, physiology, and pathology of catecholamine-containing neurons in the brain.
Implementation of arbitrary real-valued correlation filters for the shadow-casting incoherent correlator (1996)

International audience
PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects (2012)

The small heat-shock protein Hsp20 (heat-shock protein 20), also known as HspB6, has been shown to protect against a number of pathophysiological cardiac processes, including hypertrophy and apoptosis. Following β-adrenergic stimulation and local increases in cAMP, Hsp20 is phosphorylated on Ser16 by PKA (protein kinase A). This covalent modification is required for many of its cardioprotective effects. Both Hsp20 expression levels and its phosphorylation on Ser16 are increased in ischaemic myocardium. Transgenic mouse models with cardiac-specific overexpression of Hsp20 that are subject to ischaemia/reperfusion show smaller myocardial infarcts, and improved recovery of contractile performance during the reperfusion phase, compared with wild-type mice. This has been attributed to Hsp20's ability to protect against cardiomyocyte necrosis and apoptosis. Phosphomimics of Hsp20 (S16D mutants) confer improved protection from β-agonist-induced apoptosis in the heart, whereas phospho-null mutants (S16A) provide no protection. Naturally occurring mutants of Hsp20 at position 20 (P20L substitution) are associated with markedly reduced Hsp20 phosphorylation at Ser16, and this lack of phosphorylation correlates with abrogation of Hsp20's cardioprotective effects. Therefore phosphorylation of Hsp20 at Ser16 by PKA is vital for the cardioprotective actions of this small heat-shock protein. Selective targeting of signalling elements that can enhance this modification represents an exciting new therapeutic avenue for the prevention and treatment of myocardial remodelling and ischaemic injury.
Near-field ultraviolet photoluminescence spectroscopy for evaluating the crystallinity of polycrystalline zinc oxide (2001)

By extending the optical near-field technique to the ultraviolet region, a two-dimensional evaluation of the optical properties and crystallinity of polycrystalline zinc oxide (ZnO) was carried out at room temperature. Using an ultraviolet fiber probe with an aperture diameter of 80 nm, we obtained spatially resolved photoluminescence spectra from individual ZnO nanocrystallites; the emission intensity depended on the topography and on crystal orientation.
Fresnel zone imaging of Bloch-modes from a Hollow-Core Photonic Crystal Fiber Cladding (2007)

A Fresnel zone imaging technique at the output of a short length of hollow core photonic crystal fiber allows the identification of the photonic crystal cladding Bloch-modes. The experimental results show excellent agreement with theory.
D-dimer Quantification from Autologous Red Blood Cells Agglutination by a Lens-free Imaging Device (2017)

Quantification of biomarkers closest to the patient remains an impressive challenge for the development of personalized medicine. The detection of D-dimer, a fibrin degradation product, indicative of deep vein thrombosis, pulmonary embolism or stroke is a particular biomarker of interest. In this study, we developed a quantitative assay based on the measurement of autologous red blood cells agglutination by a lens-free device. An indicator, obtained from the shape of the gray level histogram of the images, allows us for a linear quantification of D-dimer opening the door for a Point-of-Care device.
ChemInform Abstract: Methyl 7‐Methoxy‐2‐naphthoate (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Modeling, analysis and design tools for dual-rate systems (2002)

This paper is concerned with dual-rate sampled-data systems modeled as dual-rate discrete systems. We assume that the continuous-time system has been already designed in order to meet continuous time-domain and frequency-domain specifications. Based on the lifting technique, dual-rate high-order-holds and discrete equivalent models are obtained. Dual-rate models are computed based on dual-rate high-order-holds and dual-rate samplers. The dual-rate equivalent model of controllers, filters, estimators, etc. are encountered in the indirect design of digital controllers. From a dual-rate point-of-view, two different situations can arise: (a) the output is sampled every NT instants and the input is updated at T (N-times faster); (b) the input is updated at NT and the output is sampled at T (N-times faster). The effectiveness of the dual-rate sampling can be studied a priori at single-rate low frequency (constrained frequency) by analyzing its effects on the system when the ratio between frequencies goes to infinity.