gebhart/patrepeval huggingface dataset:
Lower plasma melatonin levels predict worse long-term survival in pulmonary arterial hypertension (2020)

Abstract Background Exogenous melatonin has been reported to be beneficial in the treatment of pulmonary hypertension (PH) in animal models. Multiple mechanisms may be involved, with melatonin exerting anti-oxidant and anti-inflammatory effects, as well as inducing vasodilation and cardio-protection. However, endogenous levels of melatonin in treatment-naïve pulmonary arterial hypertension (PAH) patients and their clinical significance are still unknown. Methods and results Plasma levels of endogenous melatonin were measured by liquid chromatography-tandem mass spectrometry in treatment-naïve PAH patients (n=43) and healthy controls (n=111). Melatonin levels were higher in PAH patients when compared with controls (Median 118.9 [IQR 109.3–147.7] versus 108.0 [102.3–115.2] pM, P&amp;lt;0.001) (Figure 1A). The overall mortality was 26% (11/43) during a median long-term follow-up of 42 [IQR: 32–58] months. When PAH patients were stratified into 4 groups according to the quartiles of melatonin levels, the mortality from below 1st quartile to above 4th quartile was 55% (6/11), 10% (1/10), 0% (0/12), and 40% (4/10), respectively (Figure 1B). Kaplan-Meier analysis further showed that patients with melatonin levels below the 1st quartile (&amp;lt;109.3 pM) had a worse long-term survival than patients with melatonin levels above the 1st quartile (Mean survival times were 46 [95% CI: 30–65] versus 68 [58–77] months, Log-rank, p=0.026) (Figure 1C). Conclusion Endogenous melatonin levels were increased in treatment-naïve PAH patients, and lower levels of melatonin were associated with worse long-term survival in patient with PAH, however, whether exogenous melatonin supplements may be effective as a therapeutic strategy in human PAH remains to be established. Figure 1 Funding Acknowledgement Type of funding source: Foundation. Main funding source(s): This work was supported by the China Scholarship Council (201606230252) as well as the Netherlands CardioVascular Research Initiative: an initiative with support of the Dutch Heart Foundation (CVON2014-11, RECONNECT), and German Center for Cardiovascular Research (DZHK81Z0600207). Instrumentation support was received from AB Sciex, ltd. for LC-MS/MS analyses performed in this study.
A Taxonomy of Service Discovery Systems (2009)

Service discovery is a platform for network entities, whether hardware or software, to spontaneously self-configure and self-heal in a volatile environment. An in-depth understanding of the fundamentals of service discovery is essential for system architects to effectively execute pervasive and autonomous context-aware applications. We offer this understanding by clarifying some fundamental concepts and issues in service discovery; the evolution of service discovery in the context of distributed systems, the basic architectures and their variance and the different functionalities that contribute towards satisfying the self-configuring and self-healing properties of service discovery.
We then proceed to show how service discovery fits into a system, by characterizing operational aspects. Subsequently, we describe how existing state of the art performs service discovery, in relation to the operational aspects and functionalities, and identify areas for future work.
Delivering Depression Care in OB/GYN Clinics (2014)

In primary care settings, collaborative care for depression is effective; however, whether this model would also work in obstetrics and gynecology (OB/GYN) clinics, which are the sole source of healthcare for many women, is not known. Investigators randomized 205 women (mean age, 39; 44% nonwhite; 40% with …
Feel Effects (2014)

Despite a long history of use in communication, haptic feedback is a relatively new addition to the toolbox of special effects. Unlike artists who use sound or vision, haptic designers cannot simply access libraries of effects that map cleanly to media content, and they lack even guiding principles for creating such effects. In this article, we make progress toward both capabilities: we generate a foundational library of usable haptic vocabulary and do so with a methodology that allows ongoing additions to the library in a principled and effective way. We define a feel effect as an explicit pairing between a meaningful linguistic phrase and a rendered haptic pattern. Our initial experiment demonstrates that users who have only their intrinsic language capacities, and no haptic expertise, can generate a core set of feel effects that lend themselves via semantic inference to the design of additional effects. The resulting collection of more than 40 effects covers a wide range of situations (including precipitation, animal locomotion, striking, and pulsating events) and is empirically shown to produce the named sensation for the majority of our test users in a second experiment. Our experiments demonstrate a unique and systematic approach to designing a vocabulary of haptic sensations that are related in both the semantic and parametric spaces.
Poly(dimethylsiloxane) as a Material for Fabricating Microfluidic Devices (2002)

Abstract For Abstract see ChemInform Abstract in Full Text.
Mild and General Conditions for Negishi Cross‐Coupling Enabled by the Use of Palladacycle Precatalysts (2012)

Ein breites Spektrum von Biarylen ist durch palladiumkatalysierte Negishi-Kreuzkupplungen bei Raumtemperatur oder mit geringen Katalysatormengen zugänglich, wobei die katalytisch aktive XPhosPd0-Spezies aus einem Aminobiphenyl-Palladacyclus erzeugt wird. Knifflige heterocyclische und polyfluorierte aromatische Substrate ergeben die Produkte in ausgezeichneten Ausbeuten. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Pure spastic paraparesis associated with a novel presenilin 1 R278K mutation (2003)

The early-onset familial AD (EOFAD) linked to presenilin 1 ( PS1 ) mutations show a heterogeneous phenotype that is illustrated mainly by the coexistence of dementia with spastic paraparesis, described in a few kindreds.1-3⇓⇓ The altered processing of amyloid precursor protein, favoring the production of the longer amyloid β-peptide form ending at residue 42 (Aβ42), is the major pathogenic effect of PS1 mutations.4 The relationship between clinical phenotype and Aβ42 production is unclear. We report a kindred bearing a novel PS1 mutation that showed an extremely wide clinical spectrum among the three affected members.

A 45-year-old woman (I-1) showed progressive paraparesis followed after 5 years by dementia. She died at age 57, and autopsy was not performed. Her daughter (II-2) presented at 48 years with delusional thinking followed by progressive impairment of all cognitive functions. Neurologic examination at 55 years did not reveal loss of strength or pyramidal signs at the limbs. Her brother (II-3) became symptomatic at the …
Filtrage de multiples sismiques par ondelettes et optimisation convexe (2013)

Nous considerons le probleme de filtrage adaptatif de donnees sismiques composees : de signaux d'interets (primaires), de perturbations structurees correspondant a des propagations d'ondes presentant des reflexions multiples (multiples) et de bruit aleatoire. Ces signaux parasites, tres energetiques, peuvent dissimuler les reflexions primaires interessantes, correspondant aux interfaces entre couches du sous-sol. Elles peuvent etre filtrees a partir de modeles approches qu'il faut adapter en delai, amplitude et frequence. Ce travail permet de contraindre cette adaptation, sous forme de combinaisons de filtres glissants a reponses impulsionnelles finies, a varier lentement en fonction de la profondeur, respectant les variations geologiques attendues. Les approches anterieures pour ce probleme, tres important en sismique reflexion, ne semblent pas prendre en compte de contraintes sur l'adaptation, et peuvent produire des filtres tres mal conditionnes, du fait notamment du caractere passe-bande des donnees sismiques. Cette formulation du probleme permet par ailleurs d'introduire, et de resoudre par optimisation convexe, des a priori de parcimonie des signaux dans des trames d'ondelettes ainsi que de prendre en compte un bruit additif gaussien. Les multiples sont tres bien estimes. La restauration des primaires realisee permet au geophysicien de voir emerger des residus de signal utile, meme en presence de bruit fort.
ChemInform Abstract: Lewis Acid Mediated Aldol Condensations Using Thioester Silyl Ketene Acetals. (1986)

Abstract Die Umsetzung der Acetale (I) und (IIa) mit den achiralen Aldehyden (III) in Gegenwart von BF 3 ‐Etherat ergibt unabhängig von der Konfiguration der Doppelbindung in (I) und (II) nahezu ausschließlich die anti‐Produkte (IV).
A multi-user underwater acoustic positioning system – experiments using ASVs and miniature acoustic transceivers (2021)

To support the navigation of multiple autonomous underwater vehicles (AUVs) it is highly desirable to have multiuser acoustic positioning based purely upon reception of signals periodically broadcast by georeferenced positioning beacons, analogous to an underwater Global Positioning System (GPS). This paper presents a concept for achieving this using small Autonomous Surface Vehicles (ASV) as beacons in a long baseline (LBL) array. Low hardware complexity and cost is achieved by eliminating the need to maintain accurate synchronisation of underwater nodes or to incorporate high accuracy oven controlled or atomic clocks. The EU Marine Robots (EUMR) project enabled a joint experiment in the Adriatic Sea using 4 H2Omni-X ASVs, developed by the University of Zagreb, equipped with miniature, low cost spread spectrum acoustic modems (NMv3) developed by Newcastle University. Positioning results obtained, and compared with ground truth from GPS, provided a successful validation of this concept and the hardware implementation, achieving mean squared error on position estimates of $\sim$ 1m and graceful deterioration as the receiver moves outside the baselines.
Dynamic Surface Tension and Adsorption Kinetics of β-Casein at the Solution/Air Interface (2004)

A diffusion model is proposed to describe the adsorption kinetics of proteins at a liquid interface. The model is based on the simultaneous solution of the Ward-Tordai equation and a set of recently developed equations describing the equilibrium state of the adsorption layer: the adsorption isotherm, the surface layer equation of state, and the function of adsorption distribution over the states with different molar areas. The new kinetics model is compared with dynamic surface tensions of beta-casein solutions measured with the drop/bubble profile and maximum bubble pressure methods. The adsorption process for low concentrations is governed by the diffusion mechanism, while at large protein concentrations this is only the case in the initial stage. The effective diffusion coefficients agree fairly well with literature data. The adsorption values calculated from the dynamic surface tension data agree very well with the used equilibrium adsorption model.
Advanced Electrolytes Enabling Safe and Stable Rechargeable Li‐Metal Batteries: Progress and Prospects (2021)

Abstract Rechargeable Li‐metal batteries (RLBs) can boost energy yet possess poor cycle stability and safety concerns when utilizing carbonate electrolytes. Countless effort has been invested in researching and developing electrolytes for RLBs to obtain stable and safe batteries. However, only few existing electrolytes meet the requirements for practical RLBs. In this perspective, the challenges of organic liquid electrolytes in the application in RLBs are summarized, and requirements for electrolytes for practical RLBs are proposed. This perspective briefly reviews the recent achievements of electrolytes (liquid‐ and solid‐state) for RLBs and analyzes the corresponding drawbacks of each electrolyte. Further, possible solutions to the existing shortcomings of various electrolytes are proposed. In particular, this perspective outlines the development strategy of in situ gelation electrolytes, accompanied by a call for people using pouch cells to evaluate performance and paying more attention to battery safety research. This perspective aims to expound on the challenges and the possible research directions of RLBs electrolytes to promote practical RLBs better.
O<sub>2</sub>-dependent prostanoid synthesis activates functional PGE receptors on corpus cavernosum smooth muscle (2001)

We have previously demonstrated that decreased O2 tension inhibits prostaglandin synthesis from human corpus cavernosum smooth muscle cells in static culture over 8-18 h (R. B. Moreland et al., Molecular Urology 2: 41-47, 1998). In this report, an experimental system was designed that allowed determination of the effects of O2 tension changes over the time frame of physiological penile erection. Human corpus cavernosum smooth muscle cells were cultured on microcarrier beads in enclosed stirrer flasks so that rapid changes of O2 tension could be modulated. After 18 h of equilibration at 30-40 mmHg to simulate blood PO2 at penile flaccidity, O2 tension was increased to 100 mmHg for 1 h and then returned to 30-40 mmHg. Media samples were withdrawn for prostanoid synthesis and cell samples were taken for cAMP determinations. After 18 h of 30-40 mmHg PO2 values, prostanoid synthesis by human corpus cavernosum smooth muscle cells was low (0.1-0.7 pmol/10(6) cells). When PO2 was increased to 100 mmHg, a rapid increase in PGE2 >> PGF2alpha > PGD2 was observed (thromboxane A2 was undetectable), which peaked at 5.7 pmol PGE2/10(6) cells. Increased O2 tension correlated with increased PGE2 and increased intracellular synthesis of cAMP. The prostaglandin G/H synthase inhibitor indomethacin or the E prostanoid (EP2)-selective antagonist AH-6809 each inhibited the O2-tension-dependent increases in cAMP. These data support a role of differential O2 tension in the penis in the smooth muscle synthesis of PGE2, which in turn increases cAMP synthesis via EP2 receptors.
ChemInform Abstract: Silver Delafossite Oxides. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Metalated Nitriles:  Halogen−Metal Exchange with α-Halonitriles (2004)

[reaction: see text] Alpha-halonitriles react with organometallic reagents in a facile halogen-metal exchange. The halogen-metal exchange is extremely fast with Grignard and alkyllithium reagents, generating metalated nitriles in situ with aldehyde, ketone, acid chloride, and acyl cyanide electrophiles. Sequential halogen-metal exchange and methylation of conformationally constrained nitriles is highly stereoselective and consistent with a retentive alkylation of a C-magnesiated nitrile.
HARDENING OF β-TRICALCIUM PHOSPHATE MECHANICALLY TREATED BY MORTAR GRINDER (2011)

Hardening of β-tricalcium phosphate (β-TCP) mixed with a 2.5wt% Na2HPO4 aqueous solution was investigated by a compressive strength test, XRD, SEM, and calorimetry. The β-TCP starting material was ground using a mortar grinder for 7, 24, and 72 h in an air atmosphere. Compressive strength for β-TCP cement ground for 24 h was stronger than that ground for 7 h and 72 h, and was 42.8±4.1 MPa after soaking in saline for 7 days. It was found that β-TCP requires rapid hydrolysis to harden β-TCP cement. The Na2HPO4 aqueous solution facilitates this hydrolysis reaction. The compressive strength of β-TCP cement depends on the length and the number of acicular apatite crystals deposited from β-TCP.
Differential expression of miRNAs and functional role of mir-200a in high and low productivity CHO cells expressing an Fc fusion protein (2021)

These results may suggest a role for miR-200a in post-transcriptional regulation of the UPR, presenting miR-200a as a potential target for engineering industrially attractive CHO cell phenotypes.
Antifungal activity of aqueous and organic extracts from Withania somnifera L. against Fusarium oxysporum f. sp. radicis-lycopersici (2016)

The aim of this study was to evaluate the in vitro antifungal activity of aqueous and organic extracts from native Withania somnifera L. leaves, stems, and fruits against Fusarium oxysporum f. sp. radicis-lycopersici (FORL), the causal agent of Fusarium Crown and Root Rot disease in tomato. Aqueous and organic extracts (used at 1, 2, 3 and 4%) were added to molten Potato Dextrose Agar (PDA) medium. After pathogen challenge, cultures were incubated at 25°C for 5 days. All extracts tested, whatever the concentrations used, showed a strong antifungal activity toward targeted pathogen. FORL response to the different extracts assessed using the poisoned food technique, varied depending on plant organs, concentrations tested and organic solvent used for extraction. For aqueous extracts, fruit extract used at 2% exhibited the highest antifungal potential where FORL growth was decreased by 56.27%, relative to the untreated control, compared to 52 and 45.34% achieved using stem and leaf extracts at 3%, respectively. The highest antifungal activity of organic extracts was registred at the highest concentration used (4%). FORL was found to be more sensitive to fruit extracts than those from leaves and stems. Among the three organic extracts tested, butanolic fractions were the most active against FORL growth. The highest antifungal potential expressed by 62.03% decrease in pathogen radial growth was displayed by butanolic stem extracts applied at 4%. These results indicate that native W. somnifera plants may be exploited as potential source of allelochemicals biologically active against FORL.
An approach to design antennas and arrays for broadband communication and sensor systems (2007)

This work is focused on broadband signal transmission between antennas connected to front-end transmitter/receiver circuits. A design approach is developed to account for antenna&apos;s impact on system-level performance measures through decomposing systems into EM-related (antenna and channel), circuit and signal components. A set of system merits, which are measurable, is introduced. The basic results are illustrated numerically for geolocation of a transmitter using a receiver linear array. (4 pages)
Recommendations on performance characteristics of diagnostic exposure meters: Report of AAPM Diagnostic X‐Ray Imaging Task Group No. 6 (1992)

Task Group 6 of the Diagnostic X-Ray Imaging Committee of the American Association of Physicists in Medicine (AAPM) was appointed to develop performance standards for diagnostic x-ray exposure meters. The recommendations as approved by the Diagnostic X-Ray Imaging Committee and the Science Council of the AAPM are delineated in this report and provide specifications on meter precision, calibration accuracy, calibration reference points, linearity, energy dependence, exposure rate dependence, leakage, amplification gain settings, directional dependence, the stem effect, constancy checks, and calibration intervals. The report summarizes recommendations for meters used in mammography, general purpose radiography including special procedures, computed tomography, and radiation safety surveys for x-ray radiography.
<i>trans</i>-Diaquadichloridobis(<i>N</i>,<i>N</i>-dimethylformamide-κ<i>O</i>)manganese(II) (2007)

The title complex, [MnCl2(C3H7NO)2(H2O)2], was obtained upon dissolution of a dimethoxy­ethane adduct of MnCl2 in N,N-dimethyl­formamide. In the crystal structure, each MnII ion is located on a crystallographic inversion center, coordinated by two Cl [Mn—Cl = 2.53423 (17) Å] and four O [Mn—O = 2.1847 (5) and 2.2199 (6) Å] atoms in a distorted octa­hedral geometry. The complexes are linked into chains by complementary pairs of O—H⋯Cl hydrogen bonds. Adjacent chains pack via weaker O—H⋯Cl inter­actions or by inter­digitation of —NMe2 groups. The H atoms of two symmetry-related methyl groups are disordered between two orientations in a 0.51:0.49 ratio.
Detecting Cognitive Distortions Through Machine Learning Text Analytics (2017)

Machine learning and text analytics have proven increasingly useful in a number of health-related applications, particularly in the context of analyzing online data for disease epidemics and warning signs of a variety of mental health issues. We follow in this tradition here, but focus our attention on cognitive distortion, a precursor and symptom of disruptive psychological disorders such as anxiety, anorexia and depression. We collected a number of personal blogs from the Tumblr API, and labeled them based on whether they exhibited distorted thought patterns. We then used LIWC to extract textual features and applied machine learning to the resulting vectors. Our findings show that it is possible to detect cognitive distortions automatically from personal blogs with relatively good accuracy (73.0%) and false negative rate (30.4%).
Loading-Induced Bone Formation is Mediated by <i>Wnt1</i> Induction in Osteoblast-Lineage Cells (2022)

Abstract Mechanical loading on the skeleton stimulates bone formation. Although the exact mechanism underlying this process remains unknown, a growing body of evidence indicates that the Wnt signaling pathway is necessary for the skeletal response to loading. Recently, we showed that Wnts produced by osteoblast lineage cells mediate the osteo-anabolic response to tibial loading in adult mice. Here, we report that Wnt1 specifically plays a crucial role in mediating the mechano-adaptive response to loading. Independent of loading, short-term loss of Wnt1 in the Osx-lineage resulted in decreased cortical bone area in the tibias of 5-month old mice. In females, strain-matched loading enhanced periosteal bone formation in Wnt1F/F controls, but not in Wnt1F/F; OsxCreERT2 knockouts. In males, strain-matched loading increased periosteal bone formation in both control and knockout mice; however, the periosteal relative bone formation rate was 65% lower in Wnt1 knockouts versus controls. Together, these findings show that Wnt1 supports adult bone homeostasis and mediates the bone anabolic response to mechanical loading.
October Consultation # 8 (2007)

Journal of Cataract & Refractive Surgery: October 2007 - Volume 33 - Issue 10 - p 1686-1687 doi: 10.1016/j.jcrs.2007.08.012
N-linked glycan structures of glycoproteins in suspension-cultured Arabidopsis thaliana MM2d cells (2007)

The oligosaccharide structures of total glycoproteins in suspension-cultured Arabidopsis thaliana MM2d cells are determined. The N-linked sugar chains released by hydrazinolysis were labeled with 2-aminopyridine, and analyzed by a combination of HPLC, matrix-assisted laser desorption/ionization time-of-flight mass spectrometry, and exoglucosidase digestion. The glycan structures determined were GlcNAcMan3FucXylGlcNAc2 (8.5%), Man3FucXylGlcNAc2 (70.0%), Man3XylGlcNAc2 (13.7%), and GlcNAcMan3XylGlcNAc2 (7.8%). All the glycan structures of glycoproteins from Arabidopsis MM2d cells used in this study contain typical plant bisecting either β1,2-xylose or α1,3-fucose residues, showing that suspension-cultured MM2d cells have a glycosylation potential similar to that of tobacco BY2 suspension-cultured cells.