gebhart/patrepeval huggingface dataset:
Modulation of the biliary expression of arylalkylamine N-acetyltransferase alters the autocrine proliferative responses of cholangiocytes (2013)

Cholangiocytes secrete several neuroendocrine factors regulating biliary functions by autocrine/paracrine mechanisms (Alpini et al., 1994). Melatonin inhibits biliary growth and secretin-stimulated choleresis in cholestatic rats by interaction with melatonin recepror 1 (MT1) (Renzi et al., 2011). We will try to localize the key enzyme involved in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT), in cholangiocytes and, possibly, we will try to determine the effect of modulation of AANAT on the autocrine proliferative/secretory responses of cholangiocytes. In liver sections we found that: (i) AANAT is expressed by cholangiocytes and hepatocytes; (ii) the cholangiocytes expression of AANAT decreased in morpholino (AANAT down regulator)-treated rats; and (iii) the decrease in AANAT expression and subsequent lower melatonin secretion by cholangiocytes is associated with increased biliary proliferation and increased expression of Secretin Receptor (SR) and VEGFA/ C. In vitro, we observed that overexpression of AANAT in large cholangiocyte (LC) decreased proliferation and ablated secretin-stimulated biliary secretion. These results indicate that: in vivo down-regulation of biliary AANAT stimulates cholangiocyte proliferation by an autocrine loop, and in vitro overexpression of AANAT in LC decreases proliferation. Local targeting of AANAT in cholangiocytes may be important for the management of cholangiopathies.
PWM ripple currents based turn fault detection for 3-phase permanent magnet machines (2017)

Most permanent magnet (PM) machines are driven by inverter with pulse-width-modulation (PWM) voltages. The resultant phase current contains high frequency (HF) components, based on which, a new technique to detect turn fault is proposed. The machine model at high frequency is established and the HF current components are analyzed. A bandpass filter is used to extract the selected sideband components, and their root-mean-square (RMS) values are measured. The ratio of the RMS values in two adjacent phases are calculated. Both the individual ratio and the variance of 3 ratios are studied and testified to show the feasibility of detecting fault. Simulations have shown that both of them are valid fault indicator in ideal conditions while the variance is better in conditions with phase imbalance.
Spectrophotometric stopped-flow apparatus suitable for high-pressure experiments to 200 MPa (1993)

A modified high-pressure, stopped-flow apparatus has been developed to enable kinetic experiments to be monitored spectrophotometrically to 200 MPa, with efficient mixing of the reactant solutions. This apparatus is compact, relatively inexpensive to construct, and the solutions are only exposed to inert materials, such as Kel-F, Teflon, quartz (low-pressure windows), and glass or Viton. The drive-syringe pistons are propelled by a step motor housed on top of the stopped-flow unit inside the pressure vessel, resulting in a dead time for the system of ∼10 ms at 25 °C.
1P1-G05 Study on Robustness Condition for Robot Trajectories and Effectiveness of Direct Teaching Based on Parameter Space Representation : The 2nd Report : Case Study of Flexible Part Insertion(Robots for Works) (2012)

In this paper, robustness condition for robot trajectory against environmental variation and effectiveness of direct teaching are discussed based on the parameter space expression, through a case study of the flexible part insertion whose hole position is intentionally varied. According to the experimental results, the trajectories in which flexible part is actively bended are more robust than other trajectories. Moreover jamming between the flexible part and the hole tends to occur if the part is highly flexible. These results suggest that analysis of material deformation is required in order to theoretically analyze the robustness conditions. However, analytical approach to generate robot trajectories by using, e.g., FEM, is not easy and takes much time, and seems not practical for factory automation such as robotic cell production. Therefore, it is concluded flexible part insertion requires direct teaching method to generate robust trajectories.
Apolipoprotein E genotype and Lewy body disease (1995)

To determine whether apolipoprotein E (APOE) genotype affects neuropathology in Lewy body disease (LBD), we examined 18 cases of LBD that did not have concurrent Alzheimer's disease by the CERAD criteria. We obtained APOE genotypes, determined diffuse beta-amyloid plaque (A beta P) and Lewy body densities in multiple brain regions, and graded the intensity of CA2-3 ubiquitin-positive neurites, vacuolar change, nigral pathology, amyloid angiopathy, and subpial amyloid deposition. The APOE allele frequencies were as follows: epsilon 2, 0.14 +/- 0.07; epsilon 3, 0.64 +/- 0.08; and epsilon 4, 0.22 +/- 0.03. The mean A beta P density was lower in APOE epsilon 3/3 cases (14.5 A beta Ps per mm2) than in the groups with the APOE epsilon 2 (67.0) or APOE epsilon 4 (46.6) alleles. This difference was due largely to the difference between A beta P density in the APOE epsilon 2 group and the APOE epsilon 3/3 group (F = 5.525, p < 0.02). CA2-3 neuritic degeneration was greater in those with the APOE epsilon 4 allele than in those with the APOE epsilon 3/3 genotype (grade = 1.9 +/- 1.3 versus 0.938 +/- 0.9; Kruskal-Wallis test statistic = 6.962, p < 0.05). These data are consistent with the hypothesis that APOE genotype may affect neuropathology in LBD.
Brimonidine–montmorillonite hybrid formulation for topical drug delivery to the eye (2020)

Brimonidine (BMD) is often prescribed as an eye drop to reduce the intraocular pressure (IOP) for glaucoma treatment. However, eye drops are limited by rapid clearance from the preocular surface, and hence a low ocular drug bioavailability. Therefore, in this study, we propose montmorillonite (MMT), as a delivery carrier, hybridized with BMD (BMD-MMT) for topical drug delivery to the eye. The BMD-MMT hybrid was prepared by intercalating the BMD molecules in the interlayer space of the MMT lattice via ion-exchange reaction; it was then formulated with polyvinyl alcohol (PVA) to produce a dry tablet (i.e., BMD-MMT@PVA). The BMD-MMT@PVA hybrid drug released BMD in a sustained manner for more than 5 h under in vitro conditions. When the hybrid drug was administered to rabbit eyes in vivo, 43% and 18.5% BMD-MMT still remained on the preocular surface for 10 and 60 min after administration, respectively. Thus, the BMD-MMT@PVA hybrid drug exhibited a prolonged decrease in IOP, that is, for 12 h, which was approximately two times longer than that observed with the commercially available BMD eye drop, Alphagan® P.
Polarity Effect in Electrovibration for Tactile Display (2006)

Electrovibration is the tactile sensation of an alternating potential between the human body and a smooth conducing surface when the skin slides over the surface and where the current is too small to stimulate sensory nerves directly. It has been proposed as a high-density tactile display method, for example to display pictographic information to persons who are blind. Previous models for the electrovibration transduction mechanism are based on a parallel-plate capacitor in which the electrostatic force is insensitive to polarity. We present experimental data showing that electrovibratory perceptual sensitivity to positive pulses is less than that for negative or biphasic pulses and propose that this disparity may be due to the asymmetric electrical properties of human skin. We furthermore propose using negative pulses for insulated tactile displays based on electrovibration because their sensory thresholds were found to be more stable than for waveforms incorporating positive pulses.
A Unified Framework for Bandwidth Management and Motion Control of Collaborative Robotic Swarms (2021)

In this paper, we propose an algorithm that aims at unifying motion control and bandwidth management schemes via a supervisory monitor that manages a swarm of robots. The main idea of the proposed algorithm is to distribute available bandwidth among the existing communication channels in the network based on various factors representing changes occurring in the swarm and its environment. These factors include Interesting Events (IEs), Quality of Collaboration (QoCollab) between agents, Quality of Control (QoControl), and the Quality of Trajectory Generation (QoTG) of each agent of the swarm. The proposed algorithm is simulated on a fleet of two quadrotors, where the obtained results demonstrate its effectiveness in reducing network bandwidth consumption by approximately 42% as compared to two static algorithms with equal rates and equal bandwidth, while maintaining similar swarm performance.
Alkali-induced disproportionation of palladium(II) tertiary phosphine complexes, [L2PdCl2], to LO and palladium(O). Key intermediates in the biphasic carbonylation of ArX catalyzed by [L2PdCl2] (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAlkali-induced disproportionation of palladium(II) tertiary phosphine complexes, [L2PdCl2], to LO and palladium(O). Key intermediates in the biphasic carbonylation of ArX catalyzed by [L2PdCl2]Vladimir V. Grushin and Howard AlperCite this: Organometallics 1993, 12, 5, 1890–1901Publication Date (Print):May 1, 1993Publication History Published online1 May 2002Published inissue 1 May 1993https://pubs.acs.org/doi/10.1021/om00029a052https://doi.org/10.1021/om00029a052research-articleACS PublicationsRequest reuse permissionsArticle Views2244Altmetric-Citations193LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Development of the Fabry Disease Patient-Reported Outcome (FD-PRO): a new instrument to measure the symptoms and impacts of Fabry Disease (2021)

The FD-PRO is a novel, disease-specific instrument that measures the patient experience in Fabry disease. Such tools are valuable in capturing the burden of disease in patients with FD and demonstrating the value of treatment in clinical trials.
In vitro studies of the physical interactions between neurofilaments, microtubules and mitochondria isolated from the central nervous system (1991)

In order to explore the molecular nature and the regulation of dense cytomatrix which interconnects MT, NF and membranous organelles in neurons (9), the interactions between NF, MT and each of these cytoskelatal elements with brain mitochondria were investigated in vitro using biochemical and viophysical methods. From these studies, the following conclusions were drawn: 1‐ Pure NF form in vitro a highly viscous gel, dependent upon the phosphorylation state of the side arms of the NF‐H and M subunits which might participate directly to the interactions since antibodies specific of these phosphorylated sites inhibited efficiently the NF gelation. This process is modulated by both ATP hydrolysis and soluble molecules from nervous tissue and it might reflect the highly controled organization of NF bundles in axons. 2‐ In contrast with NF, low viscosity levels were detected in MT suspensions. However, the occurrence of weak interactions between MT were deduced from studies with taxol, ATP, AMP‐PNP and Mg ions, which affected the viscosity and the organization of MT in vitro, possibly through MAPs mediated interactions. 3‐ Mitochondria associated permanently in vitro to few MT through cross‐bridges involving MAPs, which bind to specific sites on the outer membrane (17). In addition, brain mitochondria (and not liver mitochondria) interact with NF in an ATP‐dependent manner, through thin cross‐bridges possibly involving the NF‐H and M subunits since these molecules, when purified, compete efficiently with MAPs for the binding to membrane sites. These results suggest the participation of structure MAPs and of NF‐H and M subunits in the spatial organization MT and NF and in anchoring mitochondria to the cytomatrix.
Operation of Droplet-Microfluidic Devices with a Lab Centrifuge (2016)

Microfluidic devices are valuable for a variety of biotechnology applications, such as synthesizing biochemical libraries, screening enzymes, and analyzing single cells. However, normally, the devices are controlled using specialized pumps, which require expert knowledge to operate. Here, we demonstrate operation of poly(dimethylsiloxane) devices without pumps. We build a scaffold that holds the device and reagents to be infused in a format that can be inserted into a 50 mL falcon tube and spun in a common lab centrifuge. By controlling the device design and centrifuge spin speed, we infuse the reagents at controlled flow rates. We demonstrate the encapsulation and culture of clonal colonies of red and green <i>Escherichia coli</i> in droplets seeded from single cells.
Escherichia coli Outer Membrane Vesicle Immunization Protocol and Induction of Bacterial Sepsis (2013)

Outer membrane vesicles (OMVs) are spherical bilayered phospholipids of 20-200 nm in size produced from all Gram-negative bacteria and Gram-positive bacteria investigated to date. OMVs, which resemble the outer membrane and periplasm in composition, are proinflammatory and immunogenic facsimiles, and therefore could activate both innate and adaptive immunity. Here, we describe the OMVs immunization protocol and bacteria challenge protocol to induce bacterial sepsis in mice.
Differentially Private Empirical Risk Minimization: Efficient Algorithms and Tight Error Bounds (2014)

In this paper, we initiate a systematic investigation of differentially private algorithms for convex empirical risk minimization. Various instantiations of this problem have been studied before. We provide new algorithms and matching lower bounds for private ERM assuming only that each data point's contribution to the loss function is Lipschitz bounded and that the domain of optimization is bounded. We provide a separate set of algorithms and matching lower bounds for the setting in which the loss functions are known to also be strongly convex. Our algorithms run in polynomial time, and in some cases even match the optimal non-private running time (as measured by oracle complexity). We give separate algorithms (and lower bounds) for $(ε,0)$- and $(ε,δ)$-differential privacy; perhaps surprisingly, the techniques used for designing optimal algorithms in the two cases are completely different. Our lower bounds apply even to very simple, smooth function families, such as linear and quadratic functions. This implies that algorithms from previous work can be used to obtain optimal error rates, under the additional assumption that the contributions of each data point to the loss function is smooth. We show that simple approaches to smoothing arbitrary loss functions (in order to apply previous techniques) do not yield optimal error rates. In particular, optimal algorithms were not previously known for problems such as training support vector machines and the high-dimensional median.
Evaluation of sleep and daytime somnolence in spinocerebellar ataxia type 6 (SCA6) (2006)

To determine the frequency of subjective sleep problems in spinocerebellar ataxia type 6 (SCA6), the authors surveyed 25 patients and 25 age-matched controls with the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI). The ESS was higher in patients with SCA6 (9.12 +/- 5.80; CI: 2.28) than in controls (4.96 +/- 3.01; CI: 1.18) (p = 0.003, t test). The PSQI was higher in patients with SCA6 (7.96 +/- 4.65; CI: 1.86) than in controls (5.08 +/- 3.39; CI: 1.36) (p = 0.018, t test).
Involvement of Vitronectin in Lipopolysaccaride-Induced Acute Lung Injury (2007)

Vitronectin is present in large concentrations in serum and participates in regulation of humoral responses, including coagulation, fibrinolysis, and complement activation. Because alterations in coagulation and fibrinolysis are common in acute lung injury, we examined the role of vitronectin in LPS-induced pulmonary inflammation. Vitronectin concentrations were significantly increased in the lungs after LPS administration. Neutrophil numbers and proinflammatory cytokine levels, including IL-1beta, MIP-2, KC, and IL-6, were significantly reduced in bronchoalveolar lavage fluid from vitronectin-deficient (vitronectin(-/-)) mice, as compared with vitronectin(+/+) mice, after LPS exposure. Similarly, LPS induced increases in lung edema, myeloperoxidase-concentrations, and pulmonary proinflammatory cytokine concentrations were significantly lower in vitronectin(-/-) mice. Vitronectin(-/-) neutrophils demonstrated decreased KC-induced chemotaxis as compared with neutrophils from vitronectin(+/+) mice, and incubation of vitronectin(+/+) neutrophils with vitronectin was associated with increased chemotaxis. Vitronectin(-/-) neutrophils consistently produced more TNF-alpha, MIP-2, and IL-1beta after LPS exposure than did vitronectin(+/+) neutrophils and also showed greater degradation of IkappaB-alpha and increased LPS-induced nuclear accumulation of NF-kappaB compared with vitronectin(+/+) neutrophils. These findings provide a novel vitronectin-dependent mechanism contributing to the development of acute lung injury.
Isotropic non-contrast whole-heart lumen only coronary MRA using local re-inversion and 2D-SENSE at 3 Tesla (2011)

Double-inversion recovery MRI with a cylindrical re-inversion prepulse has been presented for selective visualization of the coronaries [1]. Local re-inversion (LoReIn [1]) labels the blood in the ascending aorta and LV, and acquires images after a labeling delay providing coronary MRA(cMRA) of the blood flow with excellent suppression of myocardial signal. LoReIn was now implemented and tested for whole-heart cMRA [2] at high magnetic field strength.
Risk Factors for Carriage of Antibiotic-resistant Bacteria in Healthy Children in the Community (2020)

The factors that promote carriage of AR bacteria by healthy children differed between bacterial species. To reduce reservoirs of AR bacteria in the community, it is essential for intervention strategies to target the specific risk factors for different bacteria.
Blood-ocular barrier permeability in experimental myopia. (1990)

Vitreous fluorophotometry (VFP) was performed for myopic eyes induced by unilateral eyelid suturing of six young cynomolgus monkeys in order to study the permeability of the blood-ocular barrier. The eyelid fusion was temporarily cut and opened at about five-month intervals, and the dioptric power and axial length of test and control eyes were measured. VFP was carried out before and after intravenous injections of fluorescein-Na. The inward permeability of the blood-retinal barrier (P(in)) was estimated by our computer simulation method, and the index of permeability of the blood-aqueous barrier (AQ) was also obtained. Significant prolongation of the length of the vitreous cavity was first seen 10 months after suturing, with the degree of myopia progressing subsequently. P(in) and AQ values increased as myopia progressed: significant increases were observed at 10 and 16 months after suturing, respectively. These results indicate a close relationship between the occurrence and progress of myopia and increased permeability of the blood-ocular barrier.
Reliability enhancement of a steep slope tunnel transistor based ring oscillator designs with circuit interaction (2016)

Tunnel field effect transistors (TFETs) have emerged as one of the most promising post‐CMOS technologies for digital, analogue and RF designs. However, it has been demonstrated by several researchers that TFET circuits face increased on‐state Miller capacitance effect, which leads to poor transient characteristics with large overshoots and undershoots. This would minimise the reliability of TFET circuits though energy efficient. This work gives more design insights (optimal sizing, number of stages, supply voltage) into TFET circuit reliability and proposes a TFET based circuit interaction design approach for ultra‐low power and reliable ring oscillator circuit design. It has been shown that TFET circuit designs without proper reliability enhancement techniques such as circuit interaction or co‐design approach exhibits very large undershoots/overshoots (∼20–50%). The proposed TFET circuit co‐design approach (i.e. differential topology based design in comparison with the complementary static TFET logic designs) enhances the TFET circuit reliability by minimising the undershoots/overshoots to less than 0.5% with a trade‐off in operating frequency and power consumption.
Aggregation Behavior of a Symmetric, Fluorinated, Telechelic Polymer System Studied by<sup>19</sup>F NMR Relaxation (1999)

19F NMR experiments are used to study the aggregation behavior of two telechelic polymer systems. These polymer systems consist of a water−soluble chain, here poly(ethylene glycol), with two hydrophobic endgroups. Because of the hydrophobic interaction of the fluorocarbon endgroups, these polymer chains associate in water to form aggregates at low concentrations. The aggregate comprises a core formed from the insoluble hydrophobic endgroups that are surrounded by a corona of long water-soluble polymer chains. With increasing polymer concentration, the polymer chains start bridging so that a three-dimensional, physical network with fluorinated aggregate cores as cross-link points is formed. This effect can be substantially enhanced by replacing the hydrophobic endgroup C6F13 with C8F17, a consequence of the stronger association of C8F17 in aqueous solution. By different 19F NMR parameters, i.e., 19F transverse relaxation and 19F chemical shift, we can distinguish aggregated and nonaggregated chain ends. This enables us to follow the formation of an infinite network.
Improved Electrical Characteristics of Al<sub> 2</sub>O<sub> 3</sub>/InP Structure by Combination of Sulfur Passivation and Forming Gas Annealing (1999)

The capacitance-voltage (C–V) characteristics of a Al 2 O 3 /InP capacitor fabricated by helicon-wave excited O 2 –Ar plasma oxidation of vacuum–evaporated Al were significantly improved by a combination of sulfur passivation of the InP substrate in (NH 4 ) 2 S x (for 60 min) and post-thermal annealing in forming gas (FG) containing 5% H 2 (at 350°C) of the grown films after plasma oxidation. X-ray photoelectron spectroscopic (XPS) data indicated the formation of In–S bonds and suppression of InP oxidation after the sulfur passivation. The reason for the improved C–V characteristics is briefly discussed as being due to the termination of the incomplete or dangling bonds by sulfur and hydrogen.
Lateral Control Of Single Unit Heavy Vehicles (1997)

This report presents two performance enhancement lateral control designs for single unit heavy vehicles. It is shown that robust performance can be achieved using the techniques on a feedback linearized system.