gebhart/patrepeval huggingface dataset:
Increased levels of leukotriene C<sub>4</sub>in retinal pigment epithelium are correlated with early events in photoreceptor shedding in<i>Xenopus laevis</i> (1989)

The levels of 5-lipoxygenase products of arachidonic acid, leukotriene (LT) B4 and LTC4 in retinal pigment epithelia (RPE) from Xenopus laevis were measured by radioimmunoassay (RIA). RPE were isolated during various stages of photoreceptor renewal to determine possible alterations in 5-lipoxygenase activity concurrent with photoreceptor detachment and phagocytosis. Both LTC4 and LTB4 were released to RPE incubation media, although levels of LTB4 in unstimulated RPE were close to the limits of detection by RIA. Incubation of RPE with the calcium ionophore A23187 increased the levels of both LTB4 and LTC4. When animals were maintained on a cycle of 12 hr light/dark, normal photoreceptor shedding, as measured by histological quantitation of the appearance of phagosomes in the RPE, occurred 1 hr after light onset. Levels of LTC4 in RPE were lower 1 hr after light onset, as compared to 1 hr prior to light onset. Due to the low levels of LTB4, no significant differences could be detected. However, when LTB4 levels were elevated with A23187, LTB4 also declined 1 hr after light onset. When animals were maintained in constant light for 5 days, then exposed to 2 hr dark and 2 hr light, a massive shedding response occurred. Levels of LTC4 were stimulated 5 min after light onset (prior to detectable shedding) and declined below dark levels as shedding progressed. These data suggest a correlation between 5-lipoxygenase activity and the events of photoreceptor shedding and phagocytosis.
Re-evaluating membrane transport processes: New insights and appreciation of protein behavior (2009)

(2009). Re-evaluating membrane transport processes: New insights and appreciation of protein behavior. Channels: Vol. 3, No. 3, pp. 143-143.
Poly(phenylquinoxalines) containing phenylethynyl groups (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPoly(phenylquinoxalines) containing phenylethynyl groupsP. M. HergenrotherCite this: Macromolecules 1981, 14, 4, 898–904Publication Date (Print):July 1, 1981Publication History Published online1 May 2002Published inissue 1 July 1981https://pubs.acs.org/doi/10.1021/ma50005a002https://doi.org/10.1021/ma50005a002research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Fossil-energy materials program plan for fiscal years 1982 through 1986. [US DOE] (1982)

This program plan for the Department of Energy Advanced Research and Technology Development Fossil Energy Materials Program reviews the background, technical issues, and research and development needs for materials of construction for fossil energy systems. The status and plans for research and development activities in the Advanced Research and Technology Development (AR and TD) Fossil Energy Materials Program are then discussed for various materials disciplines. Detailed information about these plans is provided for FY 1982 through FY 1984, and descriptions of long-range plans are given for FY 1985 and FY 1986. In addition to descriptions of planned research activities, this plan provides levels of effort required for the various activities. Thus, the emphasis of the program on long-range basic research to address perceived materials problems in the development of fossil energy technologies is indicated.
Reconstructions of the test set images x (2015)

All images of the test set that were reconstructed with our stacked thin-film luminescent concentrator image sensor prototype. Each image shows the ground truth image on left and the reconstruction on the right. The file name contains the image number and the SSIM index.
Membrane electrical properties of guinea pig bladder smooth muscle with growth (1992)

Abstract The effect of growth on bladder membrane electrical properties was studied in guinea pigs. The electrical activity of the smooth muscle membrane in dertusor muscle strips from immature (6–8 wk) and mature (22–24 wk) guinea pigs was investigated using an intracellular microelectrode technique. The parameters measured included resting membrane potential, membrane time constant, and the action potential (AP) kinetics. The results of this study can be summarized as follows: 1) Bladder weight increased with animal growth. 2) Growth did not affect the detrusor smooth muscle resting membrane potential or membrane time constant. 3) The configuration of the detrusor muscle AP (amplitude, after hyperpolarization, and overshoot potential) and indices of AP kinetics (maximum velocities of depolarization and repolarization) were similar in immature and mature animals. The AP duration, however, showed slight prolongation in the mature adult group. These results indicate that, in the guinea pig, the passive and active electrical properties of the detrusor smooth muscle membrane do not change significantly with growth. © 1992 Wiley‐Liss, Inc.
Review on phase preserving amplitude regeneration for phase-coded signals exploiting FWM in a saturated SOA (2015)

All-optical phase-preserving amplitude regeneration is an effective method to reduce nonlinear phase noise in long-haul transmission of phase-modulated signals. Here we review the latest results on a proposed differential phase shift keying (DPSK) regeneration scheme exploiting a compact architecture based on a saturated semiconductor optical amplifier. The scheme allows for amplitude-only signal regeneration with limited excess phase-noise contribution. Both the pass-through (PT) and the four wave mixing (FWM) signals exhibit enhanced Q-factor and margin improvement in bit error rate vs receiver threshold measurements, making the configuration suitable for both wavelength-preserving optical regeneration and wavelength regenerative conversion. The regeneration through FWM has an higher resilience to noise than the PT and its polarization dependency can be eliminated with the implementation of a dual co-polarized pump scheme. Preliminary experiments of simultaneous regeneration of two DPSK data streams are also provided.
Inhibition of vascular smooth muscle cell adhesion and migration by c7E3 Fab (abciximab): a possible mechanism for influencing restenosis (2000)

c7E3 Fab inhibits the adhesion and migration of SMCs via the alpha(v)beta(3) integrin. The inhibition, however, is partial, and varied depending on type of ECM protein and alpha(v)beta(3) integrin expression. Some of the clinical benefits of c7E3 Fab may be due to its effect on SMCs.
Risk Prediction Model of 90-Day Mortality After Esophagectomy for Cancer (2021)

In this study, on the basis of preoperative variables, the IESG risk prediction model allowed stratification of an individual patient's risk of death within 90 days after esophagectomy. These data suggest that this model can help in the decision-making process when esophageal cancer surgery is being considered and in informed consent.
Near-lossless compression of digital terrain elevation data (2004)

In critical applications of image compression that are sensitive to information loss, lossless compression techniques are usually employed. The compression ratios obtained from lossless techniques are low. Hence we need different schemes that give quantitative guarantees about the type and amount of distortion incurred, viz. near-lossless compression methods. In this paper, we explore hybrid techniques for near-lossless image compression based on error bound per pixel and apply them to Digital Terrain Elevation Data (DTED). We develop multi-stage quantization methods and other hybrid schemes using SPIHT as an embedded lossy coder. The methods developed are scalable with a control on maximum allowable deviation per pixel in the reconstruction. We compare the results obtained by these methods with JPEG-LS, the standard for lossless and near-lossless compression. Results show that these methods usually perform better than JPEG-LS in terms of compression performance and have additional features useful for progressive transmission.
Fresh-Frozen Plasma as a Source of Exogenous Insulin-Like Growth Factor-I in the Extremely Preterm Infant (2008)

Transfusion of FFP to extremely preterm infants during the first postnatal week elevates levels of IGF-I and IGFBP-3.
Isolation and characterization of a sulfated polysaccharide from the brown alga <i>Sargassum patens</i> and determination of its anti-herpes activity (2003)

Bioactivity-guided fractionation of the hot water extract from the brown alga Sargassun patens led to the isolation of a polysaccharide as an antiviral component against herpes simplex viruses which are the cause of cold sores (HSV-1) and genital herpes (HSV-2). The polysaccharide contained a sulfur group that could be present as a sulfate ester. It is thus a sulfated polysaccharide with a molecular mass of about 424 kDa, and is designated SP-2a. Gas chromatographic assay showed that the polysaccharide consisted of fucose, galactose, mannose, xylose, glucose, and galactosamine. The fucose is the major constituent sugar (35.3%), followed by galactose (18.4%). The 50% effective concentration (EC50) against HSV-2, HSV-1, and HSV-1 acyclovir resistant strain was 1.3, 5.5, and 4.1 microg/mL, respectively. The 50% cytotoxic concentration (CC50) of SP-2a on the growth of normal Vero cell line was more than 4000 microg/mL. Therefore SP-2a of S. patens may be a potent agent for treating HSV infections.
A Raman lidar at La Reunion (20.8° S, 55.5° E) for monitoring water vapor and cirrus distributions in the subtropical upper troposphere: preliminary analyses and description of a future system (2011)

Abstract. A ground based Rayleigh lidar has provided continuous observations of tropospheric water vapor profiles and cirrus cloud using a preliminary Raman channels setup on an existing Rayleigh lidar above La Reunion over the period 2002–2005. With this instrument, we performed a first measurement campaign of 350 independent water vapor profiles. A statistical study of the distribution of water vapor profiles is presented and some investigations concerning the calibration are discussed. The data set having several long acquisition measurements during nighttime, an analysis of the diurnal cycle of water vapor has also been investigated. Analysis regarding the cirrus clouds is presented and a classification has been performed showing 3 distinct classes. Based on these results, the characteristics and the design of a future lidar system to be implemented at the new Reunion Island altitude observatory (2200 m) for long-term monitoring is presented and numerical simulations of system performance have been realized to compare both instruments.
Identification of Genes in <i>Thuja plicata</i> Foliar Terpenoid Defenses    (2013)

Thuja plicata (western redcedar) is a long-lived conifer species whose foliage is rarely affected by disease or insect pests, but can be severely damaged by ungulate browsing. Deterrence to browsing correlates with high foliar levels of terpenoids, in particular the monoterpenoid α-thujone. Here, we set out to identify genes whose products may be involved in the production of α-thujone and other terpenoids in this species. First, we generated a foliar transcriptome database from which to draw candidate genes. Second, we mapped the storage of thujones and other terpenoids to foliar glands. Third, we used global expression profiling to identify more than 600 genes that are expressed at high levels in foliage with glands, but can either not be detected or are expressed at low levels in a natural variant lacking foliar glands. Fourth, we used in situ RNA hybridization to map the expression of a putative monoterpene synthase to the epithelium of glands and used enzyme assays with recombinant protein of the same gene to show that it produces sabinene, the monoterpene precursor of α-thujone. Finally, we identified candidate genes with predicted enzymatic functions for the conversion of sabinene to α-thujone. Taken together, this approach generated both general resources and detailed functional characterization in the identification of genes of foliar terpenoid biosynthesis in T. plicata.
Proinflammatory Cytokines and the Hypermetabolism of Children with Sickle Cell Disease (2005)

Sickle cell anemia (HbSS) includes chronic inflammation, but the origin is unclear. We hypothesized that in stable HbSS patients the inflammation was associated with hypermetabolism. We compared selected hypermetabolic and key immunomodulator indicators in HbSS versus control children and examined associations between measures of hypermetabolism and inflammation. Twelve fasting asymptomatic HbSS children 6-12 years and 9 controls matched for age, gender and fat mass (FM) were studied. Proportional reticulocyte count (retic%) and resting energy expenditure (REE) represented hypermetabolism, and C-reactive protein (CRP) indicated inflammation. Proinflammatory cytokines tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6), chemokine monocyte chemoattractant protein-1 (MCP-1), and energy balance cytokine leptin were measured. Methods were indirect calorimetry, enzyme-linked immunosorbent assay, and radioimmunoassay. Statistical analysis included simple correlation and regression analysis. REE (51 +/- 6 vs. 43 +/- 12 kcal/kg per fat-free mass (FFM), mean +/- SD), retic% (12 +/- 4 vs. 0.7 +/- 0.3%), CRP (5 +/- 3 vs. 0.3 +/- 0.4 mg/liter), and IL-6 (71 +/- 40 vs. 20 +/- 7 pg/ml) were significantly higher for HbSS than controls (P < 0.05). Conversely, leptin (0.1 +/- 0.1 vs. 2 +/- 1 microg/liter per kgFM) and MCP-1 (34 +/- 5 vs. 41 +/- 4 pg/ml) were significantly lower for the HbSS subjects (P < 0.01). TNF-alpha was not significantly different. There were no significant associations between REE or retic% and any cytokine measured. However, CRP was significantly associated with REE in HbSS (r = 0.8, P = 0.003) and an important predictor of REE/FFM. We provide new evidence for low circulating levels of inflammatory chemokine MCP-1 in stable HbSS children, confirm mostly low cytokine levels, inflammation, and hypermetabolism and demonstrate association of hypermetabolism with inflammation via CRP but not via cytokines.
Correlation of Human in Vivo and in Vitro Cutaneous Antimicrobial Factors (1975)

the presence of antimicrobial substances on human skin was investigated. Staphyloccus aureus (10-4 colony-forming units) was applied on the forearm of 50 subjects and covered with a semiocclusive device for 24 hr. In 54% of the subjects the organisms persisted, and in 34% S. aureus was inhibited on the skin. Subjects with persistent S. aureus also had persistent Candida albicans, and vice persa. This correlation was not noted with Streptococcus pyogenes. Skin lipids from the two groups of subjects were extracted with acetone and assayed against S. aureus, S. pyogenes, and C. albicans. The percentage of S. aureus or C. albicans recovered was higher (79% and 55%, respectively) in subjects with persistent microrgamisms on their skin than in those without (47% and 28%, respectively). Subjects with persistent S. aureus and C. albicans had higher counts of normal flora (average, 9.2 times 10-3) than those on whose skin these organisms did not persist (average, 7.4 times 10-2). Coagulase-negative Staphylococcus and Micrococcus were found in higher proportions in subjects with persistent test organisms than in those without. Subjects with lower counts of their normal flora had a higher proportion of diphtheroids (34%) than the high-count group (12%).
SoC Compatible 1T1C FeRAM Memory Array Based on Ferroelectric Hf0.5Zr0.5O2 (2020)

This paper experimentally demonstrates fundamental memory array operation of a ferroelectric HfO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> -based 1T1C FeRAM. Metal/ferroelectric/metal (MFM) capacitors consisting of a TiN/ Hf <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</sub> Zr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.5</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> (HZO)/TiN stack were optimized for a sub 500°C process. Structures revealed excellent performance such as remanent polarization, 2P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> > 40 μC/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> endurance > 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sup> cycles, and 10 years data retention at 85°C. Furthermore, the MFM capacitors were successfully integrated into a 64 kbit 1T1C FeRAM array including our dedicated circuit for array operation. Back-end-of-line (BEOL) wiring showed no degradation of the underlying CMOS logic. Program and read operation were properly controlled resulting in 100 % bit functionality at an operation voltage of 2.5 V and operating speed at 14 ns. This technology matches requirements of last level cash (LLC) and embedded non-volatile-memory (NVM) in low power System-on-a-Chip (SoC) for IoT applications.
Spatial Autocorrelation in Mass Spectrometry Imaging (2016)

Mass spectrometry imaging (MSI) is a powerful molecular imaging technique. In microprobe MSI, images are created through a grid-wise interrogation of individual spots by mass spectrometry across a surface. Classical statistical tests for within-sample comparisons fail as close-by measurement spots violate the assumption of independence of these tests, which can lead to an increased false-discovery rate. For spatial data, this effect is referred to as spatial autocorrelation. In this study, we investigated spatial autocorrelation in three different matrix-assisted laser desorption/ionization MSI data sets. These data sets cover different molecular classes (metabolites/drugs, lipids, and proteins) and different spatial resolutions ranging from 20 to 100 μm. Significant spatial autocorrelation was detected in all three data sets and found to increase with decreasing pixel size. To enable statistical testing for differences in mass signal intensities between regions of interest within MSI data sets, we propose the use of Conditional Autoregressive (CAR) models. We show that, by accounting for spatial autocorrelation, discovery rates (i.e., the ratio between the features identified and the total number of features) could be reduced between 21% and 69%. The reliability of this approach was validated by control mass signals based on prior knowledge. In light of the advent of larger MSI data sets based on either an increased spatial resolution or 3D data sets, accounting for effects due to spatial autocorrelation becomes even more indispensable. Here, we propose a generic and easily applicable workflow to enable within-sample statistical comparisons.
A cloned cell line mediating natural killer cell function inhibits immunoglobulin secretion. (1982)

We previously described a cloned cell line that combines information for a unique display of cell surface antigens and specialized function similar to activated natural killer (NK) cells. In addition to conventional cellular targets such as the YAC-1 and MBL-2 lymphomas, this cloned line also lysed lipopolysaccharide-activated B lymphocytes. To determine whether some NK cells can inhibit B cell function, we tested the ability of NK-like clones to suppress Ig secretion in vitro and in vivo. These cloned cells suppressed Ig secretion when they constituted as few as 0.2% of the total cell population and inhibition did not require identity at the H-2 locus. We suggest that some NK cells might recognize non-major histocompatibility complex gene products on activated B lymphocytes and lyse these cells, and this might represent a fundamental cell-cell interaction that regulates antibody secretion by activated B cells.
Nlrp12 mutation causes C57BL/6J strain-specific defect in neutrophil recruitment (2016)

The inbred mouse strain C57BL/6J is widely used in models of immunological and infectious diseases. Here we show that C57BL/6J mice have a defect in neutrophil recruitment to a range of inflammatory stimuli compared with the related C57BL/6N substrain. This immune perturbation is associated with a missense mutation in Nlrp12 in C57BL/6J mice. Both C57BL/6J and NLRP12-deficient mice have increased susceptibility to bacterial infection that correlates with defective neutrophil migration. C57BL/6J and NLRP12-deficient macrophages have impaired CXCL1 production and the neutrophil defect observed in C57BL/6J and NLRP12-deficient mice is rescued by restoration of macrophage NLRP12. These results demonstrate that C57BL/6J mice have a functional defect in NLRP12 and that macrophages require NLRP12 expression for effective recruitment of neutrophils to inflammatory sites.
Crystallization Of The Terminal Oxygenase Component Of Biphenyl Dioxygenase Derived From Rhodococcus Sp. Strain Rha1 (2003)

The terminal oxygenase component of the biphenyl dioxygenase (BphA1A2 complex) was over-expressed with a novel over expression system in recombinant Rhodococcus strain and purified. The purified enzyme has been crystallized by the hanging drop vapor diffusion method and subjected to X-ray diffraction analysis. The crystals belong to the tetragonal system in the space group P4(1)2(1)2 or P4(3)2(1)2 and diffract to better than 2.2A resolution.