gebhart/patrepeval huggingface dataset:
Attenuation of cisplatin-induced acute kidney injury by N-(2-Hydroxyphenyl) acetamide and its gold conjugated nano-formulations in mice. (2020)

The attenuation of cisplatin-induced acute kidney injury (AKI) in mice by N-(2-hydroxyphenyl) acetamide (NA-2) and NA-2-conjugated gold nanoparticles (NA2-AuNPs) was investigated. Male BALB/c mice (n = 54) were divided into nine groups having six animals in each group. Animals in groups 3-9 were pre-treated for 5 days with test compounds, whereas, animals in group 1 and 2 received normal saline. On day 4, animals in groups 2, 3, 4, 5, 6 and 9 were given single intra-peritoneal injection of CP at the dose of 5 mg/kg. After 72 hours of CP injection, all animals were sacrificed. Blood was collected for serum urea and creatinine estimation, and kidneys were harvested for histo-pathological examinations and qPCR studies for nuclear factor-κB p50, (NFκB) ; inducible nitric oxide synthase (iNOS); hemeoxygenase-1 (HO-1); and interleukin-6 (IL-6).NA-2 and NA2-AuNPs was observed to decrease the serum urea and creatinine levels. Both the test compounds reduced kidney injury damage score and improved histological architecture in the treated animals in dose dependent manner. Furthermore, the mRNA expressions of NFkB p50, iNOS and IL-6 genes were down-regulated, and HO-1 gene was up-regulated in the animals treated with the test compounds. It is concluded that NA-2 and NA2-AuNPs attenuates CP-induced AKI in mice models through anti-inflammatory and anti-oxidant mechanisms.
Topological optimization of PLAs for yield enhancement (2002)

Several topological optimization techniques have been developed to minimize the area of PLAs. Significant yield enhancement can also be achieved by minimizing the defect sensitivity of a design that is already optimized for area. The authors propose a yield enhancement technique through which the defect sensitivity of the design will be minimized without increasing the area. This reduction in critical area is achieved primarily by minimizing the wire lengths in several layers of the layout. The yield enhancement results of the proposed technique on some benchmark PLA examples are presented.
On the isolation of a MIMO 2 × 2 antenna system using non-resonant elements: 1.71 GHz-2.69 GHz case study (2017)

A MIMO antenna system with two non-resonant antenna elements operating at the high-bands of LTE (1.71GHz–2.69GHz) is proposed. To improve the isolation, a stub has been located between the two non-resonant elements in a smartphone platform. Results for measured multiplexing efficiency and isolation are compared with and without the stub. The main conclusion is that the stub not only improves isolation but also improves the average measured multiplexing efficiency by 1dB across the band.
Induction of Four‐Dimensional Spatiotemporal Geometric Transformations in High Cell Density Tissues via Shape‐Changing Hydrogels (2021)

Developing and healing tissues begin as a cellular condensation. Spatiotemporal changes in tissue geometry, transformations in the spatial distribution of the cells and extracellular matrix, are essential for its evolution into a functional tissue. 4D materials, 3D materials capable of geometric changes, may have the potential to recreate the aforementioned biological phenomenon. However, most reported 4D materials are non-degradable and/or not biocompatible, which limits their application in regenerative medicine, and to date there are no systems controlling the geometry of high density cellular condensations and differentiation. Here, we describe 4D high cell density tissues based on shape-changing hydrogels. By sequential photocrosslinking of oxidized and methacrylated alginate (OMA) and methacrylated gelatin (GelMA), bi-layered hydrogels presenting controllable geometric changes without any external stimuli were fabricated. Fibroblasts and human adipose-derived stem cells (ASCs) were incorporated at concentrations up to 1.0 × 10<sup>8</sup> cells/mL to the 4D constructs, and controllable shape changes were achieved in concert with ASCs differentiated down chondrogenic and osteogenic lineages. Bioprinting of the high density cell-laden OMA and GelMA permitted the formation of more complex constructs with defined 4D geometric changes, which may further expand the promise of this approach in regenerative medicine applications.
Correction for Imperi et al., Repurposing the antimycotic drug flucytosine for suppression of <i>Pseudomonas aeruginosa</i> pathogenicity (2013)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Electron Density Mapping of Triblock Copolymers Associated with Model Biomembranes: Insights into Conformational States and Effect on Bilayer Structure (2008)

One-dimensional electron-density profiles derived from synchrotron small-angle X-ray scattering (SAXS) have been constructed and used to determine the conformational state of selected poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO-PPO-PEO) triblock copolymers and the region of their association with a lipid bilayer. The number of molecular repeat units in the hydrophobic PPO block has been found to determine both the nature of triblock polymer-membrane association and the conformational state of the symmetric, flanking hydrophilic PEO units. For DMPC-based biomembranes, polymers whose PPO chain length is less than that of the bilayer thickness insert weakly into the membrane with the PEO blocks on the same side of the bilayer, leading to delocalization of the PEO at the membrane-water interface. This polymer architecture has been found not to alter the membrane fluidity and roughness. Conversely, polymers whose chain length is sufficient to span the lipid bilayer are tightly integrated, projecting their PEO chains into the water channels on opposing sides of the bilayer. The coiled conformational state of the PEO chains produces steric pressure on the bilayer, causing a thinning of the membrane and leading to a rigid, less-mobile bilayer than systems where the polymer is introduced as the lipid conjugate.
Phase-locking a fiber laser array by phase contrast filtering and nonlinearity (2012)

International audience
ChRmine in MSP1E3D1 lipid nanodisc (2022)

EMPIAR, the Electron Microscopy Public Image Archive centered at EMBL-EBI, is a public resource for raw electron microscopy images related to EMDB, contains micrographs, particle sets and tilt-series.
A game theoretic approach to balance privacy risks and familial benefits (2023)

As recreational genomics continues to grow in its popularity, many people are afforded the opportunity to share their genomes in exchange for various services, including third-party interpretation (TPI) tools, to understand their predisposition to health problems and, based on genome similarity, to find extended family members. At the same time, these services have increasingly been reused by law enforcement to track down potential criminals through family members who disclose their genomic information. While it has been observed that many potential users shy away from such data sharing when they learn that their privacy cannot be assured, it remains unclear how potential users' valuations of the service will affect a population's behavior. In this paper, we present a game theoretic framework to model interdependent privacy challenges in genomic data sharing online. Through simulations, we find that in addition to the boundary cases when (1) no player and (2) every player joins, there exist pure-strategy Nash equilibria when a relatively small portion of players choose to join the genomic database. The result is consistent under different parametric settings. We further examine the stability of Nash equilibria and illustrate that the only equilibrium that is resistant to a random dropping of players is when all players join the genomic database. Finally, we show that when players consider the impact that their data sharing may have on their relatives, the only pure strategy Nash equilibria are when either no player or every player shares their genomic data.
Markers of Cerebral Lateralization and Alcoholism (1994)

We assessed markers of anomalous cerebral dominance in 70 problem drinkers at risk for alcoholism, 43 alcoholics who had been sober for at least six months, and 311 healthy control subjects age-matched to the problem drinkers. Markers of anomalous cerebral dominance included left-handedness, learning disabilities, neuro-immune disorders, and special cognitive talents. We also administered a "drinking inventory" to assess frequency and severity of drinking patterns for self and family. Analysis showed elevated rates of left-handedness and learning disabilities in the alcoholic group and in the "at risk" problem drinkers. These same subjects rated themselves and their families as relatively poor at left-hemisphere-mediated cognitive talents. Alcoholic women evidenced significantly greater incidence of immune disorders than alcoholic men. Alcoholism appears to be related to biological factors which have been associated with anomalous cerebral dominance.
Predicting the solar thermochemical water splitting ability and reaction mechanism of metal oxides: a case study of the hercynite family of water splitting cycles (2015)

We report and validate a method for predicting the solar thermal water splitting abilities of novel materials using easily calculated quantities.
Processing German Tractor Rockets with Propellant in EDS. (2009)

Abstract not provided.
A Comparison of Directional Atherectomy with Balloon Angioplasty for Lesions of the Left Anterior Descending Coronary Artery (1993)

The role of atherectomy in percutaneous coronary revascularization remains to be fully defined. However, as compared with angioplasty, atherectomy did not result in better late angiographic or clinical outcomes in patients with lesions of the proximal left anterior descending coronary artery.
Verapamil Is Not an Antidepressant in Patients Resistant to Tricyclic Antidepressants (1994)

The effects of a calcium channel blocker (verapamil, 160-320 mg/day for 4 weeks) were studied in seven unipolar major-depressed patients resistant to treatment with tricyclic antidepressants. This regimen of verapamil did not alter either the Hamilton rating scales for depression and anxiety or the Beck depression inventory score in these patients. Thus, verapamil appears devoid of antidepressant properties in patients resistant to tricyclic antidepressants.
Letter regarding "Prevalence of growth hormone deficiency in previously GH‐treated young adults with Prader‐Willi syndrome" by Donze et al (2019)

International audience
Degradation of dynamic ON-resistance of AlGaN/GaN HEMTs under proton irradiation (2013)

SiN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> -passivated AlGaN/GaN high electron mobility transistors (HEMTs) on Si substrates demonstrated high tolerance to 2 MeV proton irradiation, up to a dose of 6 × 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">14</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> . Radiation-induced changes were observed in Hall mobility, two-dimensional electron gas sheet carrier density, sheet resistance, ON-resistance, transconductance, threshold voltage, and dynamic ON-resistance. Dynamic ON-resistance was measured by pulsing to ON-state from OFF-state quiescent points with drain voltages up to 20 V. The dynamic ON-resistance measured from high OFF-state quiescent voltages was more sensitive to irradiation than the DC and Hall parameters, making the dynamic ON-resistance measurement useful in characterizing radiation-induced degradation.
Content Preference-aware User Association and Caching in Cellular Networks (2020)

The ever-growing trend of mobile users to consume high quality videos in their devices has pushed the backhaul network to its limits. Caching at Small-cell Base Stations (SBSs) has been established as an effective mechanism for alleviating this burden. Next generation mobile networks promise high Access Network density, hence multiple SBS association options per mobile user may exist. In this paper, we study the joint problem of mobile user association to SBSs and content placement to SBS-collocated caches, aiming to further optimize the utilization of backhaul network. The problem is solved periodically, considering time intervals where the users’ location to the system is assumed to be fixed. First, we decompose the joint problem into two sub-problems that are solve sequentially, namely the content preference similarity-driven user association and the demand aware content placement sub-problems. We then propose a heuristic that consists of multiple phases. In particular, at a preparation phase, it performs clustering of users based on the similarity of their content preferences, accounting also for geographical constraints. The resulting clusters are then utilized for the demand-aware association of users to the SBS, while the placement of content is driven by the resulting local demand in each SBS, and takes place at the end. We demonstrate the effectiveness of our heuristic by evaluating its performance against multiple schemes that either lack a preparation phase or do not account for geographical constraints. As it is evident through the numerical results, the user clustering that takes place during the preparation phase can increase the overall cache hit ratio up to 20%.
Mn-doped 0.15BiInO3-0.85PbTiO3 piezoelectric films deposited by pulsed laser deposition (2012)

Undoped, 0.5 and 1.0 mol. % Mn-doped 0.15BiInO3-0.85PbTiO3 films were grown on PbTiO3/Pt/Ti/SiO2/Si substrates by pulsed laser deposition. Phase-pure perovskite films were obtained at a substrate temperature of 585 °C irrespective of Mn doping level. The 0.5 mol. % Mn-doped films showed a room temperature permittivity of 480 and a dielectric loss tangent of 0.015 at 100 kHz after 650 °C post-deposition annealing. The coercive field and remanent polarization were 80 kV/cm and 29 µC/cm2, respectively. The ferroelectric transition temperature of the films ranged from 535 to 585 °C. The e31,f piezoelectric coefficient was −7.1 C/m2. X-ray diffraction and phase transition temperature data showed that the Mn atoms substitute on the Ti-site as Mn3+; the resulting films have p-type conduction characteristics.
Dielectronic recombination data for dynamic finite-density plasmas (2005)

This is an erratum for Dielectronic recombination data for dynamic finite-density plasmas II. Originally published in vol 412 (2003) page 587.
Segmentation by Classification for Through-the-Wall Radar Imaging Using Polarization Signatures (2012)

A scheme for target detection using segmentation by classification is proposed. The scheme is applied to through-the-wall microwave images obtained using frequency-domain back-projection in a wideband radar. We consider stationary targets where Doppler and change-detection-based techniques are inapplicable. The proposed scheme uses features from polarimetric images to segment and classify the image observations into target, clutter, and noise segments. We map target polarization signatures from copolarized and cross-polarized target returns to a pixel-by-pixel feature space, then oversegment the image to homogeneous regions called superpixels depending on this feature space. The features of each superpixel are used subsequently to group homogeneous superpixels into clusters. The clusters are then classified using decision trees. Real data collected using an indoor radar imaging scanner are used for performance validation.
Simulation of coupled spin torque oscillators for pattern recognition (2018)

In this paper, we use circuit-level simulations to investigate the synchronization dynamics of spin torque oscillators (STOs) and demonstrate a pattern recognition scheme based on STO dynamics. We perform a sensitivity analysis in order to determine the robustness of the different STO coupling methods, considering parameter variations, such as radius or thickness of STOs. After pointing out the advantages of the cross coupled architecture, we demonstrate a coupling scheme for pattern recognition. Several patterns are encoded in the resistive coupling network and are successfully identified, after the network has been initialized correspondingly. Finally, by extracting the corresponding impulse sensitivity function, we show how an existing analytical phase domain model can be adapted to the STO array. We compare the results of this analytical model with the numerical model of the STO and conclude that they agree well providing thus a fast method for design.
A novel POLE mutation associated with cancers of colon, pancreas, ovaries and small intestine (2015)

In some families there is an increased risk for colorectal cancer, caused by heritable, but often unidentified genetic mutations predisposing to the disease. We have identified the likely genetic cause for disease predisposition in a large family with high burden of colorectal adenomas and carcinomas, in addition to extra-colonic cancers. This family had previously been tested for known cancer susceptibility genes, with negative results. Exome sequencing was used to identify a novel mutation, c.1373A>T (p.Tyr458Phe), in the gene for DNA polymerase epsilon catalytic subunit (POLE). This mutation is located in the active site of the exonuclease domain of the enzyme, and affects a residue that has previously been shown to be important for exonuclease activity. The first predisposing mutation identified in POLE (c.1270C>G, p.Leu424Val) was associated with colorectal cancer only, but another mutation with a broader tumour spectrum (c.1089C>A, p.Asn363Lys) has recently been reported. In the family described in the present study, carriers generally have multiple colorectal adenomas and cancer of colon, pancreas, ovaries and small intestine which represents an important broadening of the tumour spectrum of POLE mutation carriers. We also observe a large phenotypic variation among the POLE mutation carriers in this family, most likely explained by modifying variants in other genes. One POLE mutation carrier has a novel variant in EXO1 (c.458C>T, p.Ala153Val), which may contribute to a more severe phenotype. The findings in this study will have important implications for risk assessment and surveillance of POLE mutation carriers.
Secreted Wnt Antagonists During Eradication of Cytomegalovirus Infection in Solid Organ Transplant Recipients (2013)

We evaluated secreted wingless (Wnt) modulators during cytomegalovirus (CMV) infection in solid organ transplant recipients (SOTr). The major findings were: (i) Plasma levels of Dickkopf-1 (DKK-1) were significantly lower in patients with CMV DNAemia above lower level of quantification at baseline. (ii) Receiver operating characteristic analysis indicated that low DKK-1 and increased secreted frizzled related protein-3 levels were predictors of poor virological outcomes during follow-up. Our findings demonstrate an imbalanced pattern of circulating secreted Wnt modulators in SOTr with poor virological outcomes following treatment for CMV disease, and may suggest a role for dysregulated Wnt signaling on viral pathogenesis during CMV infection.
Estimating the Time-of-Involvement of Bulk Packed Lithium-Ion Batteries in a Warehouse Storage Fire (2014)

A novel experimental approach was developed to evaluate the hazard posed by bulk storage of Li-ion batteries in warehouse scenarios. The flammability characteristics of cartoned small-format Li-ion batteries were evaluated via free-burn fire tests of three-tier-high rack storage arrays. For each test, only the ignition flue area of the array was lined with commodity as a means of reducing the required quantity of Li-ion batteries. Effort was placed on measurement of the fire development and, more importantly, the time of significant battery involvement, a key parameter in the hazard analysis of these fires. This parameter was inferred through diagnostics of the convective gas flow, and corroborated with visual observations and analyses of combustion products. For the tests considered herein, Li-ion batteries are shown to contribute significantly to the severity of the storage fires within 5 minutes of ignition.
Ligand-Based Prediction of Active Conformation by 3D-QSAR Flexibility Descriptors and Their Application in 3+3D-QSAR Models (2005)

A conceptionally new 3D molecular descriptor type and methodology are deduced by simple statistical thermodynamic reasoning, based on the free energy change encountered during a transformation of a conformational ensemble of the ligand to an active conformation. The performance of the descriptor was first tested on 37 endomorphin analogues with mu-opiate activity. The method resulted in predictive 3D-QSAR models, and the active conformation was also predicted. Generally, the methodology can be combined with the traditional 3D-QSAR techniques in a 3+3D-QSAR manner. This feature was tested on a series of 38 PGF2alphaprostaglandin analogues with antinidatory activity; the extent to which the molecular flexibility explains the variation in the biological activity was estimated and the active conformation was predicted. The novel descriptors in combination with the grid-based SOMFA descriptors resulted in 3+3D-QSAR models with good levels of predictivity leading to the approach of separation of the effect of the molecular interaction field of the active conformation and the effect of the conformational free energy loss.
Optical properties of CaSrSiO4:Eu2+ phosphors prepared by using a solid-state reaction method for white light-emitting diodes (2015)

We have studied the optical properties of CaSrSiO4:Eu2+ phosphors synthesized by using the conventional solid-state reaction method and the role of Eu3+ minority ions in those phosphors. The maximum photoluminescence integrated peak intensity was observed for the Ca1−x Sr1−x SiO4:2xEu2+ (2x = 0.0050) phosphor. A red shift of 3 nm from 510 to 513 nm in the emission wavelength of the CaSrSiO4:Eu2+ phosphors was observed with increasing Eu concentration. Under an excitation of 244 nm, the Ca1−x Sr1−x SiO4:2xEu2+ (2x = 0.0050) phosphor showed a broad emission band at about 515 nm due to the 4f 65d 1 → 4f 7 transition of the Eu2+ and small sharp peaks at about 594, 612, and 701 nm corresponding to the 5D 0-7 F J transitions of Eu3+. The existence of Eu3+ minority ions in the phosphor resulted in a broader full width at half maximum in the emission of the phosphor at the excitation wavelength of 390 ~ 400 nm, even at low Eu concentration. The white light-emitting diodes (LEDs) were fabricated by using the CaSrSiO4:Eu2+ phosphors and 400-nm GaN-based LED chips and exhibited a high color rendering index of ~ 95 and correlated color temperature of ~ 5370 K. The broad emissions of the CaSrSiO4:Eu2+ phosphors combined with the GaN-based LED chips are suitable for the realization of white LEDs.
Aqueous Na-ion Redox Flow Battery with Ceramic NaSICON Membrane. (2017)

A redox flow battery is described herein that has a sodium-super-ionic-conductor NaSICON barrier disposed between an anolyte chamber of the battery and the catholyte chamber of the battery. The NaSICON barrier prevents crossover of solvents or active redox species between the anolyte chamber and the catholyte chamber, while permitting transport of sodium ions between the chambers. In exemplary embodiments, the anolyte chamber includes an anolyte solution that comprises a first active redox species dissolved in a first solvent, while the catholyte chamber includes a catholyte solution that comprises a second active redox species dissolved in a second solvent.
(Tab 2) Average signal to noise ratio (SNR) for individual microarray probes in an alluvial aquifer along the Colorado River in Rifle, Colorado, USA (2015)

(Tab 2) Average signal to noise ratio (SNR) for individual microarray probes in an alluvial aquifer along the Colorado River in Rifle, Colorado, USA