gebhart/patrepeval huggingface dataset:
A Numerical Investigation of the Effect of Inlet Preswirl Ratio on Rotordynamic Characteristics of Labyrinth Seal (2018)

Full three-dimensional (3D) computational fluid dynamics (CFD) simulations are carried out using ANSYS cfx to obtain the detailed flow field and to estimate the rotordynamic coefficients of a labyrinth seal for various inlet swirl ratios. Flow fields in the labyrinth seal with the eccentricity of the rotor are observed in detail and the detailed mechanisms that increase the destabilizing forces at high inlet swirl ratios are discussed based on the fluid governing equations associated with the flow fields. By evaluating the contributions from each term of the governing equation to cross-coupled force, it is found that circumferential velocity and circumferential distribution of axial mass flow rate play key roles in generating cross-coupled forces. In the case that circumferential velocity is high and decreases along the axial direction, all contributions from each term are positive cross-coupled force. On the other hand, in the case that circumferential velocity is low and increases along the axial direction, one contribution is positive but the other is negative. Therefore, cross-coupled force can be negative in the local chamber depending on the balance even if circumferential velocity is positive. CFD predictions of cross-coupled stiffness coefficients and direct damping coefficients show better agreement with experimental results than a bulk flow model does by considering the force on the rotor in the inlet region. Cross-coupled stiffness coefficients derived from the force on the rotor in the seal section agree well with those of the bulk flow model.
Sequenzen in partiell an den Doppelbindungen halogeniertem 1,4-Polybutadien (2008)

ZusammenfassungAn einen Teil der Doppelbindungen von 1,4-Polybutadien wird Brom bzw. Chlor addiert. Die Polymeren werden durch Metathese mit 2-Buten bzw. 4-Octen abgebaut. Für die Statistische Anlagerung wird eine Verteilungsfunktion für die Länge der halogenierten Sequenzen abgeleitet und an den Abbau mittels Olefin-Matathese angepaßt. Nach den experimentellen Ergebnissen ist eher eine statistische Addition des Halogens als eine Addition in Blöcken oder eine alternierende Verteilung anzunehmen.
Involvement of an SHP-2-Rho Small G Protein Pathway in Hepatocyte Growth Factor/Scatter Factor–induced Cell Scattering (2000)

Hepatocyte growth factor/scatter factor (HGF/SF) induces cell scattering through the tyrosine kinase-type HGF/SF receptor c-Met. We have previously shown that Rho small G protein (Rho) is involved in the HGF/SF-induced scattering of Madin-Darby canine kidney (MDCK) cells by regulating at least the assembly and disassembly of stress fibers and focal adhesions, but it remains unknown how c-Met regulates Rho activity. We have found here a novel signaling pathway of c-Met consisting of SHP-2-Rho that regulates the assembly and disassembly of stress fibers and focal adhesions in MDCK cells. SHP-2 is a protein-tyrosine phosphatase that contains src homology-2 domains. Expression of a dominant negative mutant of SHP-2 (SHP-2-C/S) markedly increased the formation of stress fibers and focal adhesions in MDCK cells and inhibited their scattering. C3, a Clostridium botulinum ADP-ribosyltransferase, and Y-27632, a specific inhibitor for ROCK, reversed the stimulatory effect of SHP-2-C/S on stress fiber formation and the inhibitory effect on cell scattering. Vav2 is a GDP/GTP exchange protein for Rho. Expression of a dominant negative mutant of Vav2 blocked the stimulatory effect of SHP-2-C/S on stress fiber formation. Conversely, expression of mutants of Vav2 that increased stress fiber formation inhibited HGF/SF-induced cell scattering. These results indicate that SHP-2 physiologically modulates the activity of Rho to form stress fibers and focal adhesions and thereby regulates HGF/SF-induced cell scattering. In addition, Vav2 may be involved in the SHP-2-Rho pathway.
Online Machine Learning for 1-Day-Ahead Prediction of Indoor Photovoltaic Energy (2023)

We explore the potential for predicting indoor photovoltaic energy on a forecasting horizon of up to 24 hours. The objective is to enable energy management approaches that exploit harvesting opportunities more strategically, for which they require more accurate energy intake predictions. Our study is based on a data set covering over 3 years, for which we simulate online machine learning algorithms with different amounts of training data and input features. Our results show that relatively simple machine learning methods can outperform a persistent predictor considerably, and we observed a reduction of errors of up to 56%. When devices obtain a significant amount of sunlight, adding the weather forecast improves the prediction accuracy. We discuss prediction features, the amount of training data and analyze the sources of errors to understand the potential of indoor photovoltaic energy harvesting predictions.
Isolation of coronaviruses antigenically indistinguishable from bovine coronavirus from wild ruminants with diarrhea (1995)

Diarrheal feces from three sambar deer and one waterbuck in a wild animal habitat and one white-tailed deer on a wildlife farm in Ohio contained coronavirus particles which were agglutinated by antiserum to bovine coronavirus (BCV) in immune electron microscopy. Three coronavirus strains were isolated in human rectal tumor cells from the feces of the sambar and white-tailed deer and the waterbuck, respectively. Hemagglutination, receptor-destroying enzyme activity, indirect immunofluorescence, hemagglutination inhibition, virus neutralization, and Western blot (immunoblot) tests showed close biological and antigenic relationships among the isolates and with selected BCV strains. Gnotobiotic and colostrum-deprived calves inoculated with each of these isolates developed diarrhea and shed coronavirus in their feces and from their nasal passages. In a serological survey of coronavirus infections among wild deer, 8.7 and 6.6% of sera from mule deer in Wyoming and from white-tailed deer in Ohio, respectively, were seropositive against both of the isolates and selected BCV isolates by indirect immunofluorescence tests. These results confirm the existence of coronaviruses in wild ruminants and suggest that these species may harbor coronavirus strains transmissible to cattle.
Sodium-Directed Photon-Induced Assembly Strategy for Preparing Multisite Catalysts with High Atomic Utilization Efficiency (2023)

Integrating different reaction sites offers new prospects to address the difficulties in single-atom catalysis, but the precise regulation of active sites at the atomic level remains challenging. Here, we demonstrate a sodium-directed photon-induced assembly (SPA) strategy for boosting the atomic utilization efficiency of single-atom catalysts (SACs) by constructing multifarious Au sites on TiO<sub>2</sub> substrate. Na<sup>+</sup> was employed as the crucial cement to direct Au single atoms onto TiO<sub>2</sub>, while the light-induced electron transfer from excited TiO<sub>2</sub> to Au(Na<sup>+</sup>) ensembles contributed to the self-assembly formation of Au nanoclusters. The synergism between plasmonic near-field and Schottky junction enabled the cascade electron transfer for charge separation, which was further enhanced by oxygen vacancies in TiO<sub>2</sub>. Our dual-site photocatalysts exhibited a nearly 2 orders of magnitude improvement in the hydrogen evolution activity under simulated solar light, with a striking turnover frequency (TOF) value of 1533 h<sup>-1</sup> that exceeded other Au/TiO<sub>2</sub>-based photocatalysts reported. Our SPA strategy can be easily extended to prepare a wide range of metal-coupled nanostructures with enhanced performance for diverse catalytic reactions. Thus, this study provides a well-defined platform to extend the boundaries of SACs for multisite catalysis through harnessing metal-support interactions.
IL-23 induces regulatory T cell plasticity with implications for inflammatory skin diseases. (2017)

Abstract Foxp3+ regulatory T cells (Tregs) are a major fraction of T cells in the skin. At steady state, Treg cells make little to no inflammatory cytokines and control against inflammation. However, under certain autoimmune inflammatory settings (including psoriasis) Treg cells have been shown to become dysfunctional, making pro-inflammatory cytokines and contributing to disease pathogenesis. To better understand the role of Treg cells in psoriasis we analyzed the homeostasis and function of these cells in a mouse model of psoriasiform dermatitis (IL-23 mediated skin inflammation). We find that IL-23 induced inflammation drove both proliferation and increased accumulation of Foxp3+T cells in the skin. Furthermore, IL-23 induced a population of Foxp3+T cells that expressed RORgt and made IL17A. The induction of this putative pathogenic population was completely abrogated by a RORgt inverse agonist that inhibits RORgt signaling in vivo. IL-23 was also sufficient to drive the generation of Foxp3+RORgt+IL17A+ cells in vitro, suggesting a cell intrinsic role for IL-23. Interestingly, IL-23 did not induce production of other pro-inflammatory cytokines like IFN-g by Treg cells. This is in line with recent studies where both increased accumulation and the ability of Foxp3+ T cells to make IL17A was reported in lesional skin of psoriasis patients. Current efforts are focused on better defining the characteristics of Foxp3+RORgt+IL17A+ cells in lesional skin of psoriatic patients and mice treated with IL-23. Collectively, our data suggests that IL-23 drives Treg cell plasticity by inducing a population of Foxp3+RORgt+IL17A+ cells that is regulated by RORgt signaling and could be relevant to disease pathogenesis.
A DIGITAL RAD1 AND SOURCE OCESSOR FOR CHANNEL DEMODULATION DING OF SATELLITE RADIO PROGRAMS (1996)

New satellite based digital radio standards have been developed recently. The advantages of these standards (CD-like sound quaky, small bandwidth requirements, embedded digital data services) require considerable larger modulation and demodulation eforts because forward error correction and sophisiticated data compression techniques are used. A commercial success of these radio systems is closely related to the availablity of low cost receiver equipment. This paper describes the concept and the architecture of a chipset that is designed for the demodulation of digital radio signals according to the european ALII?') standard. The chipset consists of the MSP2) -chip which is already widely used in standard satellite receivers or Tv sets and the newly developed Digital Radio Processor (DRP) as a coprocessor for ADR decoding. The presented chipset allows a very cost-ef fective upgrade of standard satellite receivers for digital broadcast reception because substantial parts of the analog TV-sound processing are used for ADR-demodulation as well. Both IC's of the chipset are based on DSP-cores that provides a highjexibilty with respect to modijkations and additional Jeatures.
NLOS mitigation in FMCW RADAR with CLEAN peak detection (2017)

A secondary frequency modulated continuous wave (FMCW) RADAR with two-way ranging can be used for indoor and outdoor positioning with high precision and accuracy. However, non-line-of-sight (NLOS) conditions lead to multipath effects that have a negative impact on the quality of ranging and positioning measurements, if the spectral analysis is not able to detect the correct line-of-sight (LOS) path. This work proposes an improved peak detection algorithm - based on CLEAN - that works on the base band spectra in each RADAR base station, in order to enable LOS path detection. In a simple ranging scenario at 3 m distance, the conventional parabolic interpolation for sub-bin resolution exhibits errors of up to 1.5 m (50%) for a large fraction of the measurements. The CLEAN algorithm, however, improves upon this by drastically reducing the number of outliers. In a positioning scenario, the parabolic interpolation exhibits errors between 0.2-0.8 m, the CLEAN algorithm reduces this error to below 0.5 m.
Ginseng (2014)

Physical memory is the scarcest resource in today's cloud computing platforms. Cloud providers would like to maximize their clients' satisfaction by renting precious physical memory to those clients who value it the most. But real-world cloud clients are selfish: they will only tell their providers the truth about how much they value memory when it is in their own best interest to do so. How can real-world cloud providers allocate memory efficiently to those (selfish) clients who value it the most?
Combination therapy with etanercept and rituximab in relapsed CLL/SLL (2008)

7065 Background: Rituximab has modest activity in relapsed chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL) but is associated with TNF-α release that can cause CLL proliferation and inhibit apoptosis. We examined whether disruption of TNF-a signaling by etanercept would improve response duration to rituximab in CLL. Methods: Eligible adult patients (pts) had previously treated CLL with a performance status 0–3. Pts received etanercept 25 mg subcutaneously twice weekly (weeks 1–5) and rituximab 375 mg/m2 intravenously three times weekly (weeks 2–5). Primary endpoints were response, toxicity, and progression-free survival (PFS). An abbreviated phase I followed by a two-stage phase II design was used. Results: Between 11/02 and 6/06, 36 pts with CLL/SLL were enrolled. Pts had a median of 2 prior treatments, 50% were fludarabine-refractory, and 22% had del(17p13.1). 33 pts completed therapy, and 34 patients were evaluable for response. Using NCI 96 criteria, 10 pts (overall response rate [ORR] 29%) had responses including 9 partial responses and 1 complete remission. Response rate was not affected by prior rituximab treatment (ORR 33%) and fludarabine-refractory status (ORR 28%), but no responses were observed in pts with del(17p13.1). Median response duration was 12.3 (range 4–48) months and median PFS was 6.5 (range 1–52) months. 10 pts have had treatment-free intervals exceeding 12 months, including 3 who have remained untreated for 24, 35 and 48 months, respectively. Adverse events were mild, including grade 1/2 infusion reactions (39%), grade 3/4 cytopenias (anemia 3%, thrombocytopenia 19%, and neutropenia 33%), and grade 3 infections (14%). No CMV reactivation or opportunistic infections were observed. Conclusions: The combination of etanercept and thrice weekly rituximab produces durable remissions in non-del(17p13.1) CLL patients and is well tolerated. Future investigation of this combination therapy in elderly pts who are not candidates for aggressive chemoimmunotherapy should be pursued. No significant financial relationships to disclose.
Development of Enhanced Primer Sets for Detection of Norovirus (2015)

Norovirus (NV) is a major viral pathogen that causes nonbacterial acute gastroenteritis and outbreaks of food-borne disease. The genotype of NV most frequently responsible for NV outbreaks is GII.4, which accounts for 60-80% of cases. Moreover, original and new NV variant types have been continuously emerging, and their emergence is related to the recent global increase in NV infection. In this study, we developed advanced primer sets (NKI-F/R/F2, NKII-F/R/R2) for the detection of NV, including the variant types. The new primer sets were compared with conventional primer sets (GI-F1/R1/F2, SRI-1/2/3, GII-F1/R1/F2, and SRII-1/2/3) to evaluate their efficiency when using clinical and environmental samples. Using reverse transcription polymerase chain reaction (RT-PCR) and seminested PCR, NV GI and GII were detected in 91.7% (NKI-F/R/F2), 89.3% (NKII-F/R/R2), 54.2% (GI-F1/R1/F2), 52.5% (GII-F1/R1/F2), 25.0% (SRI-1/2/3), and 32.2% (SRII-1/2/3) of clinical and environmental specimens. Therefore, our primer sets perform better than conventional primer sets in the detection of emerged types of NV and could be used in the future for epidemiological diagnosis of infection with the virus.
Patient-derived, vaccine-elicited MUC1 antibodies mediate immune effector functions against cancer cells (2019)

Abstract Cancer cells undergo changes that the immune system recognizes, and this can be leveraged for therapy. Antibodies specific for such changes can exert anti-tumor effects via multiple mechanisms, including blocking oncogenic signaling, serving as Trojan horses carrying toxic compounds, coordinating innate immune engagement for cytotoxicity through cellular and non-cellular means, and promoting antigen uptake to jumpstart adaptive immunity for durable protection. We analyzed 12 high-affinity fully human IgG1 monoclonal antibodies that recognize a tumor-specific hypoglycosylated form of Mucin-1 (MUC1) that is overexpressed in &amp;gt;80% of all cancers. These antibodies are unique and different from humanized murine anti-MUC1 mAbs, having undergone selection and affinity maturation in individuals receiving the MUC1-100mer peptide vaccine (Lohmueller et al. Sci. Rep. 2016). Importantly, in all vaccinated individuals that generated antibodies to MUC1, there have been no adverse events in 8 years, increasing the likelihood that as therapeutic agents they would be safe. To test their immune effector capacity, we used these human anti-MUC1 antibodies in in vitro antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP) and complement-dependent cytotoxicity (CDC) assays with different huMUC1-expressing cell lines, immune effector cells and serum. Several of the anti-MUC1 antibodies can mediate ADCC by NK cells and ADCP by macrophages, although there was very little or no CDC function. Notably, unlike in published studies on rituximab and alemtuzumab, the amount of antibody binding to cancer cells (MUC1) did not always correlate with increased effector function.
Long-Term Follow-Up of IV Busulfan (Bu) with Fludarabine (Flu) vs IV Bu with Cyclophosphamide (Cy) as Pre (Allogeneic) Transplant Conditioning Therapy for AML/MDS. (2006)

Abstract We previously demonstrated early safety and efficacy of fixed-dose IV BuFlu. Here we compare IV BuFlu and IV BuCy2, with long follow-up in a large number of pts. Since pts were treated on consecutive, not randomized programs, we used pts receiving Flu-Melphalan (M) in a program spanning the time of the IV Bu-based studies to estimate/correct for this non-randomized “period” effect. Methods: 293 pts received Bu 130 mg/m2, Flu 40 mg/m2 (after April 2001; n=148); Bu 0.8 mg/kg × 16, Cy 60 mg/kg × 2 (before April 2001; n=67); Flu 30mg/m2 × 4, M 140–180 mg/m2 (FM; before and after April 2001; n=78). Patients received FM mainly based on higher age and coorbidities. Graft-vs-host dx (GVHD) prophylaxis was tacrolimus-based. Bayesian log-normal regression models were used to assess covariate- and treatment effects on survival, non-relapse mortality (NRM) and time to progressive disease (TPD). Covariates and survival model are shown in the table. The model accounts for the “period” effect, the effects of Bu-vs-FM, and Flu-vs-Cy within IV Bu pts. Patient and treatment characteristics were (BuFlu, BuCy2 and FM): median age 46 (19–66), 39 (13–64) and 54 (22–74) years. At HSCT 47%, 48% and 21% of the patients were in CR1-3. Donors were HLA-identical siblings in 53%, 79% and 41%. 30% of the Bu groups and 47% of FM had poor prognosis cytogenetics. Results: Median follow-up in months (BuFlu, BuCy2 and FM; alive pts): 30 (9–56; n=80; all but 2 pts followed for at least 1 yr), 69 (24–102; n=23) and 48 (17–89, n=25). 100-day NRM for pts in CR at HSCT was 2% and 9% after Bu-Flu and BuCy2, while 1 yr-NRM was 7% and 18%. BuFlu produced significantly better EFS (P=0.04) and overall NRM (P=0.02) than BuCy2, but TPD was similar (P=0.34). 2-yr actuarial survival (CR pts): 75% (BuFlu) vs. 50% (BuCy), P=0.01. Conclusion: After accounting for covariate and treatment period effects, there was a significant benefit to being treated with BuFlu compared to BuCy2 in spite of a higher median age and proportion of MUDs. The benefit was most evident for CR-pts due to a significant reduction in NRM, without loss of antileukemic activity due to exchanging Cy with Flu. Fitted Bayesian log-normal overall survival model Variable Mean SD Posterior 95% credible interval 2.5% 97.5%* Probability of beneficial effect *1=beneficial effect; 0=low likelihood of beneficial effect Cytogenetics −0.85 0.4 −1.652 −0.045 0.017 Disease status (CR vs other) 1.12 0.55 0.019 2.15 0.975 Donor (sibling vs other) 0.606 0.237 0.149 1.056 0.992 Age −0.022 0.010 −0.041 −0.003 0.017 Circulating blasts (0 vs &gt;0) 0.951 0.268 0.454 1.463 1 Platelet count 0.002 0.001 0.000 0.004 0.967 Period effect −0.914 0.458 −1.795 0.041 0.029 IV Bu (vs FM) −0.513 0.481 −1.455 0.420 0.148 BuFlu (vs Bucy2) 1.476 0.544 0.406 2.555 0.995 Survival – patients in CR at transplant Survival – patients in CR at transplant
Imaging technologies from bench to bedside (2015)

The last few decades have seen tremendous advances in medicine that have enhanced understanding of pathophysiological processes at the cellular and molecular level, and led to the development of increasingly sophisticated diagnostic imaging technologies. Early detection of disease induced molecular and functional changes before induction of irreversible structural changes is key for optimal treatment efficacy. Non-invasive imaging modalities, such as positron emission tomography (PET) [1], single photon emission computed tomography (SPECT) [2], computed tomography (CT) [3], optical tomographic technologies [4], magnetic resonance imaging (MRI) [5], ultrasound (US) [6], and X-rays play a vital role in both the diagnosis and monitoring of disease in response to therapy. These techniques cover a broad range of spatio-temporal resolution and varying degrees of sensitivity and specificity to different molecular changes, and in many cases provide complementary information [7,8]. Recently discovered molecular targets of various disease states, including oncology, neurodegenerative and neuropsychiatric, cardiovascular, and musculoskeletal pathologies, drive further developments in the imaging field to detect these new molecular markers. Ultimately, these technologies contribute to improved disease management and personalized patient care.
ChemInform Abstract: Asymmetric Induction in Allylic Alkylation via Enantiotopic Facial Discrimination. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.