gebhart/patrepeval huggingface dataset:
Very frequent loss of heterozygosity throughout chromosome 17 in sporadic ovarian carcinoma (1993)

Frequent loss of heterozygosity (LOH) on both arms of chromosome 17 has been described in ovarian carcinoma (OC) by a number of groups, and the recent fine mapping of an inherited breast-ovarian cancer gene (brcAI) to a small region at 17q12-21 has focused interest on this area. We studied 28 sporadic OCs with 21 markers at 18 loci on chromosome 17 (5 on 17p and 13 on 17q). LOH on 17p was 78%, and always involved p53. In 86% of cases showing LOH, all informative markers on chromosome 17 showed reduction to homozygosity. Using 6 markers flanking the brcAI locus on 17q, LOH was 75%, but only one tumour showed LOH with telomeric retention. The data therefore suggest that small deletions on chromosome 17 are very uncommon in sporadic OC. No genomic rearrangements by Southern blotting were seen in the brcAI candidate gene estradiol 17 beta dehydrogenase 2 (17hsd2), or in erbB2, prohibition (phb) and nmeI (previously nm23-HI). LOH on chromosome 17 was more common in high-grade, late-stage carcinomas, and no LOH was seen in any benign or borderline tumour. This study has clearly demonstrated that LOH at any one site on chromosome 17 is most commonly explained by LOH over the whole of the chromosome. We consider possible reasons for the absence of small deletions on chromosome 17 in OC.
Perioperative Outcomes for the Emergent Whipple Operation in the United States: An Analysis of the American College of Surgeons National Surgical Quality Improvement Program (2017)

Ivanics, Tommy MD; Rubinfeld, Ilan MD, FACS; Kwon, David S. MD, FACS Author Information
Microchirurgie robotique dans la chirurgie nerveuse périphérique (2016)

Les techniques de microchirurgie stagnent depuis les années 1960. Les propriétés de la robotique (disparition du tremblement, magnification du geste opératoire, etc.) permettent de créer un nouveau concept : la microchirurgie endoscopique robot-assistée.
A Negative Word-line Voltage Step-Down Erase Pulse Scheme with ΔV&lt;sub&gt;TH&lt;/sub&gt;=⅙ ΔV&lt;sub&gt;ERASE&lt;/sub&gt; for Enterprise SSD Application Ferroelectric(Fe)-NAND Flash Memories (2009)

2009 International Conference on Solid State Devices and Materials,A Negative Word-line Voltage Step-Down Erase Pulse Scheme with ΔV<sub>TH</sub>=⅙ ΔV<sub>ERASE</sub> for Enterprise SSD Application Ferroelectric(Fe)-NAND Flash Memories
ChemInform Abstract: Facile Synthesis of 2‐Azaazulenes from Thiobenzoyl Isocyanates Using Trimethylsilyldiazomethane. (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Timing and Predictors of T2-Lesion Resolution in Patients With Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease (2023)

The high frequency of spontaneous T2-lesion resolution suggests that this represents MOGAD's natural history. The speed of T2-lesion resolution and influence of size, corticosteroids, and T1-hypointensity on this phenomenon gives insight into MOGAD pathogenesis.
Wavelet transform cardiorespiratory coherence for monitoring nociception (2010)

Heart rate variability (HRV) may provide anesthesiologists with a noninvasive tool for nociception monitoring during general anesthesia. A novel wavelet transform cardiorespiratory coherence (WTCRC) algorithm was used to calculate estimates of the linear coupling between heart rate and respiration. WTCRC was tested on clinical data from 19 pediatric patients receiving general anesthesia during dental surgery. WTCRC decreased during nociception, and increased following additional anesthetic drugs. Data were divided into categories with normal respiratory rate (RR) (in the HF band) and low RR (in the LF band), then split into 2-minute windows. WTCRC and LF/HF were calculated for each window and compared in each category. The algorithms showed correlations of −0.5506 and −0.1403 for data with normal and low RR, respectively. WTCRC and LF/HF are comparable when the RR is normal, and WTCRC significantly outperforms when the RR is low.
The pathophysiology of vascular calcification in a rodent model of chronic kidney disease (2010)

Vascular calcification (VC) occurs in aging populations, but is markedly accelerated in patients with chronic kidney disease (CKD). Through manipulation of dietary adenine, we produced a Sprague Dawley rat model characterized by graded severity of CKD with VC. Circulatory changes were determined by arterial radiotelemetry (n=6) and by assessment of aortic pulse wave velocity (PWV; n=32). VC was assessed using the calcium‐O‐cresophthalein assay and von Kossa staining. At sacrifice, kidney function (creatinine (μmol/L)) was worst in the CKD group with VC (251±60 μmol/L), compared to CKD alone (200±69 μmol/L) or control (50±16 μmol/L). Longitudinal serum phosphate measures revealed that those CKD animals with the highest serum phosphate mid‐study and prior to the development of circulatory changes (i.e. radiotelemetry) subsequently developed calcification (5.96±1.3 mM in calcifying CKD versus 4.4±1.3 mM in CKD versus 2.8±0.2 mM in control). VC animals also demonstrated elevated PWV (3.2±0.3 log(cm/s) vs control 2.9±0.1 log(cm/s)) and widening pulse pressure ((PP) 38±4.7 mmHg to 58 ±15.2 mmHg). Furthermore, there were positive correlations between the phosphate regulating hormone, fibroblast growth factor 23, and PP with left ventricular hypertrophy (LVH; r 2 =0.32 &amp; r 2 =0.58 respectively, p&lt;0.005). Hyperphosphatemia and VC in CKD are likely mechanistically linked and are key factors in enhanced LVH.
Magnetoresistance of CdSe/CdS quantum dot films (2009)

Films of n-type CdSe/CdS colloidal quantum dots show positive and negative magnetoresistance (MR) with magnetic field lower than 0.4 T. The MR sign and magnitude vary with the occupancy of the lowest state, the temperature, and the electrical field. Low occupancy leads to +20% MR at 10 K, while high occupancy leads to ∼−5% MR. The MR reaches +35% in mixed samples of large and small dots. Intrinsic films are photoconductive and display positive MR.
PDMS, a safe shelter for flexible W-BAN antennas (2014)

This contribution describes a new technology for the realization of soft, flexible, and robust antennas intended to operate in a harsh environment. The method is based on the use of a silicon based elastomer, Polydimethylsiloxane (PDMS) for the substrate material, and copper mesh or any kind of perforated metal plates as flexible conductive materials. The initial liquid state of the PDMS allows a lot of freedom in the fabrication process, both from the electrical and mechanical point of view. The electric and mechanic properties of the substrate can be adjusted by loading the PDMS with low or high permittivity inclusions, controlling thus the permittivity and the rigidity. Copper meshes or perforated metal structures enable good adhesion between the substrate and conductor and improve the overall flexibility. Measured results show good repetitiveness of the substrate samples, both with or without inclusions. Several antenna prototypes have been built and tested through washing and bending in order to assess their robustness to environmental changes.
Polycyclodextrin and Carbon Nanotubes as Composite for Tyrosinase Immobilization and Its Superior Electrocatalytic Activity Towards Butylparaben an Endocrine Disruptor (2014)

We developed a protocol for the immobilization of tyrosinase (Tyr) on the composite of polycyclodextrin polymer (CDP) and carbon nanotubes for the detection of an endocrine disruptor, i.e., butylparaben (BP). The formation of the CDP polymer was characterized by UV-Vis spectrophotometry. The conducting film of cross-linked CDP and carbon nanotubes, displays excellent matrix capabilities for Tyr immobilization. The host-guest chemical reaction ability of CD and the π-π stacking interaction assure the bioactivity of Tyr towards butylparaben. The developed biosensor was characterized electrochemically by electrochemical impedance spectroscopy. The enzyme-substrate kinetic parameters such as the apparent Michaelis-Menten constant (K(M)(app)) was measured under saturated substrate concentration. The determination of butylparaben was carried out by using square wave voltammetry over the concentration range of 2.1 to 35.4 μM with a detection limit of 0.1 μM. The fabricated biosensor was successfully applied in real-life cosmetic samples with good recovery ranging from 98.5 to 102.8%.
Endothelial P-Selectin as a Target of Heparin Action in Experimental Melanoma Lung Metastasis (2004)

Spontaneous and experimental metastasis can be effectively inhibited by the widely used anticoagulant heparin in different tumor models. At the cellular level, many of the antimetastatic effects of heparin in vivo are due to its action on P-selectin-mediated binding. Whereas previous attention has focused on P-selectin-dependent tumor-cell-platelet interactions in blood-borne metastasis, we sought to address the potential contribution of endothelial P-selectin expression to adhesive events between the microvasculature and melanoma cells in vivo. Transplantation of bone marrow from P-selectin-deficient into wild-type mice conveyed inhibition of ex-perimental melanoma metastasis. However, the extent to which bone marrow-conferred lack of platelet P-selectin expression attenuated melanoma lung metastasis was significantly less than that seen in P-selectin-deficient mice, suggesting that endothelial P-selectin expression may additionally contribute to formation of hematogenous metastases. This assumption was supported by our intravital microscopy studies, in which a significant proportion of melanoma cells were capable of directly interacting with postcapillary venules of the murine ear in a P-selectin-dependent manner. Heparin not only inhibits P-selectin-mediated melanoma cell rolling but also attenuates melanoma metastasis formation in vivo, further supporting the concept that endothelial P-selectin expression may represent an additional target of heparin action in experimental melanoma lung metastasis.
REGULATION OF PULMONARY VASOCONSTRICTION BY AGONISTS AND CAVEOLAE (2008)

Sustained pulmonary vasoconstriction contributes to the elevated pulmonary vascular resistance observed in pulmonary arterial hypertension. A rise in cytosolic Ca(2 +) in pulmonary artery smooth muscle cells (PASMCs) is major trigger for pulmonary vasoconstriction. One family of drugs currently being pursued as a potential treatment for pulmonary hypertension are the statins, which act by depleting cholesterol and reducing the number of caveolae. This study aimed at investigating the role of caveolae, membrane receptors, and ion channels (that are potentially located in the caveolae) in agonist-mediated pulmonary vasoconstriction in order to gain a greater understanding of the signaling mechanisms involved in the regulation of pulmonary vascular tone. Chronic treatment of PASMCs with the cholesterol-depleting agent, methyl-beta -cyclodextrin (Mbeta CD), significantly reduced the number of cholesterol rich caveolae regions in the membrane. This disruption of cholesterol in caveolae significantly inhibited pharmacomechanical (induced by phenylephrine), but not electromechanical (induced by elevated extracellular potassium concentration), rat pulmonary artery contraction. These results indicate that receptors may functionally colocalize in caveolae in PASMCs and coordinate to regulate pulmonary vascular tone.
Transport and quantum electron mobility in the modulation Si δ-doped pseudomorphic GaAs/In0.2Ga0.8As/Al0.2Ga0.8As quantum well grown by metalorganic vapor phase epitaxy (2000)

A study of transport and quantum mobility of electrons in two-dimensional electron gas (2DEG) in the modulation Si δ-doped pseudomorphic GaAs/In0.2Ga0.8As/Al0.2Ga0.8As quantum well (QW) grown by metalorganic vapor phase epitaxy is presented. Well-resolved Shubnikov–de Haas oscillations of the magnetoresistivity observed at T=4.2 K suggest that the 2DEG with high electron mobility (μt≈46 000 cm2/V s) formed in the QW with no significant parallel conduction. A persistent photoconductivity effect resulted in an increase in electron sheet density. An increase of transport and quantum mobilities up to the onset of the second subband occupancy was observed. Further illumination resulted in a decrease of both mobilities. Strong dependence of the quantum mobility on the thermal history of the investigated sample was attributed to the effect of actual distribution of ionized centers in the sample.
Detecting EEG bursts after hypoxic-ischemic injury using energy operators (2002)

During recovery following episodes of hypoxic-ischemic (HI) injury in the neonate, the electroencephalogram (EEG) recovers with sporadic, fluctuating energy discharges known as "bursts" and periods of electrical silence ("burst suppression"). Prior to the resumption of normal activity, the individual pattern of bursting may hold important diagnostic information regarding neurological outcome. Detection and characterization of the bursts seems to be an important factor in understanding the dynamics of the recovering EEG. The Teager Energy Algorithm (TEA) is a new method to describe abrupt EEG energy changes. Prior to the resumption of continuous EEG we coupled the use of the TEA and sequential detection to describe the start and stop time of bursts. Employing a dominant frequency model, the TEA provides distortion-free reproduction of signal energy without the need for filtering high or sum frequency components portions. In an animal model of neonatal HI injury, we showed that TEA provides efficient detection of burst and burst suppression episodes. Burst counts might provide indicators of neurological and behavioral outcomes.
ChxR is a transcriptional activator in <i>Chlamydia</i> (2006)

Chlamydia spp. are obligate intracellular bacterial pathogens that alternate between two metabolically and morphologically distinct developmental forms, and differentiation depends on transcriptional regulation. Genome sequencing of Chlamydia trachomatis revealed an ORF, CT630 (chxR), whose amino acid sequence contains a winged helix-turn-helix motif similar to the DNA-binding domain of response regulators in the OmpR subfamily. ChxR differs from many response regulators in that essential residues in the receiver or phosphorylation domain are lacking. ChxR functions as a transcriptional regulator because it activated transcription of ompF and ompC when expressed in Escherichia coli. In vitro transcription combined with microarray analysis also demonstrated that ChxR activates its own expression by binding directly to sites upstream of chxR; it also activates infA, tufA, oppA, and CT084. DNase I protection studies showed that ChxR bound to sites in the ompF and ompC promoter proximal regions that overlap but were distinct from OmpR binding sites. Both proteins could bind simultaneously to their nonoverlapping binding sites. This report identifies a stage-specific transcriptional regulator and some of its target genes in Chlamydia.
Analysis of Amikacin-Resistant Pseudomonas aeruginosa Developing in Patients Receiving Amikacin (1989)

During a 36-month period, 28 patients treated for infections due to amikacin-susceptible Pseudomonas aeruginosa subsequently developed infections or colonization with amikacin-resistant P aeruginosa at the same site. Eleven amikacin-susceptible/-resistant pairs of isolates were analyzed for aminoglycoside-inactivating enzymes, plasmid profiles, cellular proteins, outer membrane proteins (OMPs), lipopolysaccharide (LPS) profiles, and amikacin uptake. While clearly distinct from isolates of other patients, sensitive and resistant isolates from the same patients were indistinguishable in plasmid profile, LPS profiles, and OMPs. These results suggest that the resistant P aeruginosa isolates were derived from the sensitive isolates. None of the resistant isolates produced enzymes known to inactivate amikacin. In nine of 11 resistant isolates tested, transport of amikacin into P aeruginosa was reduced. A major mechanism of in vivo development of amikacin resistance in P aeruginosa is alteration in permeability to amikacin, but the aquisition of plasmids or changes in OMPs or LPS profile may not account for this phenomenon.
Check-ins and Photos: Spatiotemporal Correlation-Based Location Inference Attack and Defense in Location-Based Social Networks (2018)

In Location-Based Social Networks (LBSNs) users' interaction is largely carried through check-ins and photo sharing. The study of location privacy issues with check-ins has yielded different Location Privacy-Preserving Mechanisms (LPPMs), including dummies to hide user's whereabouts in a set of dummy locations without using a trusted-third party(TTP). However, the impact of shared photos on location privacy is yet to be understood. Our experiment on real data from a LBSN reveals that, like the check-ins, the spatial distribution of shared photos can influence user's location privacy. In this paper, we propose an inference model based on spatial distribution of historical check-ins and photos, and show that it is possible to deduce user's location at a high accuracy through spatiotemporal analysis of multiple events, comprising check-ins and photos. In the process, we evaluate state-of-the-art dummy mechanisms with the proposed inference model to stress the limitation of existing LPPMs. Then, we design a LPPM, called photo-check, to protect user privacy in LBSN for both check-in and photos; and carry out the experiment with real data from Foursquare to show its effectiveness and efficacy.
Library (2016)

Biomolecular screening is now a crucial component of the drug discovery process, and this glossary will be of use to practitioners in the field of screening and to those who interact with the screening community. The glossary contains definitions related to various aspects of the screening process such as assay types, data handling, and relevant technologies. Many of the terms used in this discipline are not covered by existing glossaries, and where they are, the definitions are often not appropriate for this field. Where appropriate, this document provides new or modified definitions to better reflect the new context. The field of biomolecular screening is multidisciplinary in nature, and this glossary, containing authoritative definitions, will be useful not only for regular practitioners, but also for those who make use of data generated during the screening process.
High loop-filter-order ΣΔ-fractional-n frequency synthesizers for use in frequency-hopping-spread-spectrum communication-systems (2003)

Frequency-hopping spread-spectrum wireless digital communication-systems impose stringent requirements on both phase noise and settling time of PLL based frequency synthesizers employed in receivers and transmitters. If a /spl Sigma//spl Delta/-fractional-N-synthesizer is used either the reference frequency or the loop filter order must therefore be high. We theoretically investigate PLLs of higher order and find that the settling time of a sixth order PLL suitable for operation in a Bluetooth transceiver can be as low as 7 /spl mu/s in spite of a reference frequency of 16 MHz.
High performance liquid chromatographic separation of polycyclic aromatic hydrocarbons on microparticulate pyrrolidone and application to the analysis of shale oil (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh performance liquid chromatographic separation of polycyclic aromatic hydrocarbons on microparticulate pyrrolidone and application to the analysis of shale oilT. H. Mourey, Sidney. Siggia, P. C. Uden, and R. J. CrowleyCite this: Anal. Chem. 1980, 52, 6, 885–891Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1 May 1980https://pubs.acs.org/doi/10.1021/ac50056a026https://doi.org/10.1021/ac50056a026research-articleACS PublicationsRequest reuse permissionsArticle Views90Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
High Power Fiber Lasers based on very large Mode Area Fiber Designs – Challenges and Prospects (2014)

Rare-earth-doped fiberlasers and amplifiers have established themselves as an attractive and power scalable solid-state laser concept for various applications in science and industry. The prospects for future developments using advanced fiber designs will be discussed.
A flow handover protocol to support state migration in softwarized networks (2019)

Summary Softwarized networks are the key enabler for elastic, on‐demand service deployments of virtualized network functions. They allow to dynamically steer traffic through the network when new network functions are instantiated, or old ones are terminated. These scenarios become in particular challenging when stateful functions are involved, necessitating state management solutions to migrate state between the functions. The problem with existing solutions is that they typically embrace state migration and flow rerouting jointly, imposing a huge set of requirements on the on‐boarded virtualized network functions (VNFs), eg, solution‐specific state management interfaces. To change this, we introduce the seamless handover protocol (SHarP). An easy‐to‐use, loss‐less, and order‐preserving flow rerouting mechanism that is not fixed to a single state management approach. Using SHarP, VNF vendors are empowered to implement or use the state management solution of their choice. SHarP supports these solutions with additional information when flows are migrated. In this paper, we present SHarP's design, its open source prototype implementation, and show how SHarP significantly reduces the buffer usage at a central (SDN) controller, which is a typical bottleneck in state‐of‐the‐art solutions. Our experiments show that SHarP uses a constant amount of controller buffer, irrespective of the time taken to migrate the VNF state.