gebhart/patrepeval huggingface dataset:
Inter- and intramolecular carbon-hydrogen bond forming and cleavage reactivity of two different types of poly(trimethylphosphine)ruthenium intermediates (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInter- and intramolecular carbon-hydrogen bond forming and cleavage reactivity of two different types of poly(trimethylphosphine)ruthenium intermediatesJohn F. Hartwig, Richard A. Andersen, and Robert G. BergmanCite this: J. Am. Chem. Soc. 1991, 113, 17, 6492–6498Publication Date (Print):August 1, 1991Publication History Published online1 May 2002Published inissue 1 August 1991https://pubs.acs.org/doi/10.1021/ja00017a021https://doi.org/10.1021/ja00017a021research-articleACS PublicationsRequest reuse permissionsArticle Views467Altmetric-Citations30LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Concept2Box: Joint Geometric Embeddings for Learning Two-View Knowledge Graphs (2023)

Zijie Huang, Daheng Wang, Binxuan Huang, Chenwei Zhang, Jingbo Shang, Yan Liang, Zhengyang Wang, Xian Li, Christos Faloutsos, Yizhou Sun, Wei Wang. Findings of the Association for Computational Linguistics: ACL 2023. 2023.
Flouescence reference materials used for optical and biophotonic applications (2007)

Fluorescence techniques are known for their high sensitivity and are widely used as analytical tools and detection methods for product and process control, material sciences, environmental and bio-technical analysis, molecular genetics, cell biology, medical diagnostics, and drug screening. According to DIN/ISO 17025 certified standards are used for fluorescence diagnostics having the drawback of giving relative values for fluorescence intensities only. Therefore reference materials for a quantitative characterization have to be related directly to the materials under investigation. In order to evaluate these figures it is necessary to calculate absolute numbers like absorption/excitation cross sections and quantum yield. This can be done for different types of dopands in different materials like glass, glass ceramics, crystals or nano crystalline material embedded in polymer matrices. Based on the optical spectroscopy data we will discuss options for characteristic doped glasses and glass ceramics with respect to scattering and absorption regime. It has shown recently for YAG:Ce glass ceramics that for a proper determination of the quantum efficiency in these highly scattering media a reference material with similar scattering and fluorescent properties is required. This may be performed using the emission decay measurement diagnostics, where the decay time is below 100 ns. In this paper we present first results of these aspects using well performing LUMOGEN RED organic pigments for a comparison of mainly transparent glass with glass ceramics doped with various amounts of dopands e.g. ions of raw earth elements and transition metals. The LUMOGEN red is embedded in silica and polyurethane matrices. Characterisations on wavelength accuracy and lifetime for different environmental conditions (temperature, UV irradiation) have been performed. Moreover intensity patterns and results for homogeneity, isotropy, photo and thermal stability will be discussed. In a next step we will show the transfer of the characterisation methods to inorganic fluophores (YAG:Ce) in silicon. Fluorescence (steady state, decay time) and absorption (remission, absorption) spectroscopy working in different temperature regimes (10 &minus; 350 K) are employed diagnostic methods in order to get a microscopic view of the relevant physical processes and to prove the correctness of the obtained data. The work is funded by BMBF under project number 13N8849.
Podoplanin-Fc burns out platelets (2010)

In this issue of Blood, Cueni and colleagues have demonstrated that podoplanin-Fc not only displays an inhibitory effect on lymphatic vessel formation, but also induces platelet aggregation and disseminated intravascular coagulation (DIC) in transgenic mice.
Effects of Platinum Additions and Sulfur Impurities on the Microstructure and Scale Adhesion Behavior of Single-Phase CVD Aluminide Bond Coatings (1999)

The adhesion of alumina scales to aluminide bond coats is a life-limiting factor for some advanced thermal barrier coating systems. This study investigated the effects of aluminide bond coat sulfur and platinum contents on alumina scale adhesion and coating microstructural evolution during isothermal and cyclic oxidation testing at 1150 C. Low-sulfur NiAl and NiPtAl bond coats were fabricated by chemical vapor deposition (CVD). Lowering the sulfur contents of CVD NiAl bond coatings significantly improved scale adhesion, but localized scale spallation eventually initiated along coating grain boundaries. Further improvements in scale adhesion were obtained with Pt additions. The observed influences of Pt additions included: (1) mitigation of the detrimental effects of high sulfur levels, (2) drastic reductions in void growth along the scale-metal interface, (3) alteration of the oxide-metal interface morphology, and (4) elimination of Ta-rich oxides in the Al{sub 2}O{sub 3} scales during thermal cycling. The results of this study also suggested that the microstructure (especially the grain size) of CVD aluminide bond coatings plays a significant role in scale adhesion.
Anomaly Detection using Clustered Deep One-Class Classification (2020)

Anomalies on Cyber-Physical System (CPS) can have a devastating effect on the entire system of complex CPS. Thus, it is important to detect anomalies quickly. Since CPS can collect sensor data in near real-time throughout the process, many attempts have been made to solve this problem from the perspective of data-driven security based on the collected data. However, since the CPS datasets are big data and most of the data are normal data, it has always been a great challenge to analyze the data and implement the anomaly detection model. In this paper, we propose and evaluate the Clustered Deep One-Class Classification (CD-OCC) model that combines the clustering algorithm and deep learning (DL) models using only a normal dataset for anomaly detection. We classify normal data into optimal cluster size using the K-means clustering algorithm. DL models train to classify each cluster based on clustered normal data, and we can obtain the softmax values in the process of predicting the cluster. We use the softmax values as a dataset with distilled knowledge of the DL model for anomaly detection. We transfer the softmax values to one-class classification (OCC) models to detect anomalies. As a result of the experiment, the F1-score of the proposed model shows performance close to 0.8 and performance improvement of about 0.5 compared to the encoded OCC model, which has reduced-dimensionality through auto-encoder as well as the basic OCC model.
An Essential Role for Liver ERα in Coupling Hepatic Metabolism to the Reproductive Cycle (2016)

Lipoprotein synthesis is controlled by estrogens, but the exact mechanisms underpinning this regulation and the role of the hepatic estrogen receptor α (ERα) in cholesterol physiology are unclear. Utilizing a mouse model involving selective ablation of ERα in the liver, we demonstrate that hepatic ERα couples lipid metabolism to the reproductive cycle. We show that this receptor regulates the synthesis of cholesterol transport proteins, enzymes for lipoprotein remodeling, and receptors for cholesterol uptake. Additionally, ERα is indispensable during proestrus for the generation of high-density lipoproteins efficient in eliciting cholesterol efflux from macrophages. We propose that a specific interaction with liver X receptor α (LXRα) mediates the broad effects of ERα on the hepatic lipid metabolism.
Using Loaded N-Port Structures to Achieve the Continuous-Space Electromagnetic Channel Capacity Bound (2023)

A method for achieving the continuous-space electromagnetic channel capacity bound using loaded <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> -port structures is described. It is relevant for the design of compact multiple-input multiple-output (MIMO) antennas that can achieve channel capacity bounds when constrained by size. The method is not restricted to a specific antenna configuration and a closed-form expression for the channel capacity limits are provided with various constraints. Furthermore, using loaded <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$N$ </tex-math></inline-formula> -port structures to represent arbitrary antenna geometries, an efficient optimization approach is proposed for finding the optimal MIMO antenna design that achieves the channel capacity bounds. Simulation results of the channel capacity bounds achieved using our MIMO antenna design with one square wavelength size are provided. These show that at least 18 ports can be supported in one square wavelength and achieve the continuous-space electromagnetic channel capacity bound. The results demonstrate that our method can link continuous-space electromagnetic channel capacity bounds to MIMO antenna design.
Inside-Outside Stereoisomerism. 6.+ Synthesis of trans-Bicyclo[4.4.1]undecan-11-one and the First Stereoselective Construction of the Tricyclic Nucleus of the Ring System of the Ingenane Diterpenes (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInside-Outside Stereoisomerism. 6.+ Synthesis of trans-Bicyclo[4.4.1]undecan-11-one and the First Stereoselective Construction of the Tricyclic Nucleus of the Ring System of the Ingenane DiterpenesJeffrey D. Winkler, Kevin E. Henegar, Bor-Cherng Hong, and Paul G. WilliardCite this: J. Am. Chem. Soc. 1994, 116, 10, 4183–4188Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 May 1994https://pubs.acs.org/doi/10.1021/ja00089a006https://doi.org/10.1021/ja00089a006research-articleACS PublicationsRequest reuse permissionsArticle Views557Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
The Wide World of Molecular Profiling for Tumor Classification (2017)

Featured Article: Gene-expression profiles predict survival of patients with lung adenocarcinoma. Beer DG, Kardia SL, Huang CC, Giordano TJ, Levin AM, Misek DE, et al. Nat Med 2002;8:816–24.2

As the past millennium was coming to an end and we were about to enter a new one, the National Cancer Institute (NCI) director issued a request for applications in which the scientific community was challenged to submit proposals “to harness the power of comprehensive molecular analysis technologies to make the classification of tumors vastly more informative.” The director invited investigators to form multidisciplinary research groups with proposals to exploit 1 or a related set of comprehensive molecular analysis technologies for the examination of tumor specimens. Together with a group of investigators at the University of Michigan, we submitted a proposal to exploit comprehensive gene expression and proteomic technologies to …
Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice (2020)

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in 2019 as the causative agent of the novel pandemic viral disease COVID-19. With no approved therapies, this pandemic illustrates the urgent need for safe, broad-spectrum antiviral countermeasures against SARS-CoV-2 and future emerging CoVs. We report that remdesivir (RDV), a monophosphoramidate prodrug of an adenosine analog, potently inhibits SARS-CoV-2 replication in human lung cells and primary human airway epithelial cultures (EC <sub>50</sub> = 0.01 μM). Weaker activity was observed in Vero E6 cells (EC <sub>50</sub> = 1.65 μM) due to their low capacity to metabolize RDV. To rapidly evaluate <i>in vivo</i> efficacy, we engineered a chimeric SARS-CoV encoding the viral target of RDV, the RNA-dependent RNA polymerase, of SARS-CoV-2. In mice infected with chimeric virus, therapeutic RDV administration diminished lung viral load and improved pulmonary function as compared to vehicle treated animals. These data provide evidence that RDV is potently active against SARS-CoV-2 <i>in vitro</i> and <i>in vivo</i> , supporting its further clinical testing for treatment of COVID-19.
Translating Orthopaedic Technologies Into Clinical Practice: Challenges and Solutions (2018)

Despite the wealth of innovation in the orthopaedic sciences, few technologies translate to clinical use. By way of a 2-day symposium titled "AAOS/ORS Translating Orthopaedic Technologies into Clinical Practice: Pathways from Novel Idea to Improvements in Standard of Care Research Symposium," key components of successful commercialization strategies were identified as a passionate entrepreneur working on a concept aimed at improving patient outcomes and decreasing the cost and burden of disease; a de-risking strategy that has due recognition of the regulatory approval process and associated costs while maximizing the use of institutional, state, and federal resources; and a well thought-out and prepared legal plan and high quality, protected intellectual property. Challenges were identified as a lack of education on the scale-up and commercialization processes; few opportunities to network, get feedback, and obtain funding for early stage ideas; disconnect between the intellectual property and the business model; and poor adoption of new technologies caused in part by un-optimized clinical trials. By leveraging the network of professional orthopaedic societies, there exists an opportunity to create an enlightened community of musculoskeletal entrepreneurs who are positioned to develop and commercialize technologies and transform patient care.
Dynamic logic for belief revision (2007)

We show how belief revision can be treated systematically in the format of dynamicepistemic logic, when operators of conditional belief are added. The core engine consists of definable update rules for changing plausibility relations between worlds, which have been proposed independently in the dynamic-epistemic literature on preference change. Our analysis yields two new types of modal result. First, we obtain complete logics for concrete mechanisms of belief revision, based on compositional reduction axioms. Next, we show how various abstract postulates for belief revision can be analyzed by standard modal frame correspondences for model-changing operations.
Power-Law Fluctuation in Expressway Traffic Flow: Detrended Fluctuation Analysis (2006)

The temporal behavior of expressway traffic flow is a complex mixture of various time scales. The fundamental response time of drivers is on the order of 1 s, and the periodic appearances of traffic congestion reflect our social activities. We need some filters to extract proper dynamical fluctuations from raw observed traffic data. We employ the detrended fluctuation analysis (DFA) for studying long-range correlation in the time sequence of traffic flow. The time series of expressway traffic flow is understood to consist of periodic trends with power-law fluctuation. The power spectrum P ( k ) behaves as P ( k )∼ k -β with β∼1. The power-law fluctuation is observed in the wide time range from minutes to months.
Cation and anion channelrhodopsins: Sequence motifs and taxonomic distribution (2021)

ABSTRACT Cation and anion channelrhodopsins (CCRs and ACRs, respectively) primarily from two algal species, Chlamydomonas reinhardtii and Guillardia theta , have become widely used as optogenetic tools to control cell membrane potential with light. We mined algal and other protist polynucleotide sequencing projects and metagenomic samples to identify 75 channelrhodopsin homologs from three channelrhodopsin families, including one revealed in dinoflagellates in this study. We carried out electrophysiological analysis of 33 natural channelrhodopsin variants from different phylogenetic lineages and 10 metagenomic homologs in search of sequence determinants of ion selectivity, photocurrent desensitization, and spectral tuning in channelrhodopsins. Our results show that association of a reduced number of glutamates near the conductance path with anion selectivity depends on a wider protein context, because prasinophyte homologs with the identical glutamate pattern as in cryptophyte ACRs are cation-selective. Desensitization is also broadly context-dependent, as in one branch of stramenopile ACRs and their metagenomic homologs its extent roughly correlates with phylogenetic relationship of their sequences. Regarding spectral tuning, two prasinophyte CCRs exhibit red-shifted spectra to 585 nm, although their retinal-binding pockets do not match those of previously known similarly red-shifted channelrhodopsins. In cryptophyte ACRs we identified three specific residue positions in the retinal-binding pocket that define the wavelength of their spectral maxima. Lastly, we found that dinoflagellate rhodopsins with a TCP motif in the third transmembrane helix and a metagenomic homolog exhibit channel activity. IMPORTANCE Channelrhodopsins are widely used in neuroscience and cardiology as research tools and are considered as prospective therapeutics, but their natural diversity and mechanisms remain poorly characterized. Genomic and metagenomic sequencing projects are producing an ever-increasing wealth of data, whereas biophysical characterization of the encoded proteins lags behind. In this study we used manual and automated patch clamp recording of representative members of four channelrhodopsin families including a family that we report in this study in dinoflagellates. Our results contribute to a better understanding of molecular determinants of ionic selectivity, photocurrent desensitization, and spectral tuning in channelrhodopsins.
Simultanübersetzung durch Maschinen (2013)

University without Language Barriers Introducing the First Simultaneous Translation Service by Computer - Simultaneous Speech Translation In an increasingly mobile and global world, universities are faced with the problem of language barriers like never before. Should a German university switch to English, or must all students learn German before enrolling? On June 11th, we will unveil a third solution: the world's first automatic simultaneous translation service at a university.
Repeated manual evacuation for treatment of rectal tears in four horses (1999)

Horses with tears that involve all layers of the rectum except the mesocolon (grade IIIb) have a poor prognosis for survival because of the difficulty in treating these wounds and the propensity for them to progress to full perforations (grade IV). Most treatments for grade-IIIb rectal tears involve surgery of some kind, but not all grade-IIIb rectal tears require surgical intervention. We report on 4 horses with grade-IIIb rectal tears that were evaluated via palpation per rectum and endoscopy. Two of 4 horses were admitted with signs consistent with shock and endotoxemia, and evaluation of all peritoneal fluid samples was indicative of nonseptic peritonitis. Horses were treated via administration of antibiotics and anti-inflammatory drugs and repeated manual evacuation of the terminal portion of the small colon and rectum. Treatment centered on preventing further enlargement of the rectal tear by eliminating the storage function of the terminal portion of the small colon and rectum. None of our horses had worsening of the original injury, and horses were discharged within 2 weeks of admission with full resolution of the rectal tear. Outcomes in the horses of our report indicate that repeated manual evacuation can be successful for treatment of horses with grade-IIIb rectal tears.
Herstellung und selektive Umsetzungen von gemischt bimetallischen aromatischen und heteroaromatischen Bor‐Magnesium‐Reagentien (2005)

Die Mischung macht's: Die Magnesierung von Iodaryl- und Iodheteroarylboronsäureestern mit iPrMgCl⋅LiCl führt zu gemischt bimetallischen Verbindungen, die durch Reaktion mit Elektrophilen die Synthese hochfunktioneller Boronsäureester ermöglichen (siehe Schema). Diese neuen Reagentien gehen unterschiedliche Suzuki-Kreuzkupplungen ein und führen so zu mehrfach substituierten aromatischen und heteroaromatischen Verbindungen. Hintergrundinformationen zu diesem Beitrag sind im WWW unter http://www.wiley-vch.de/contents/jc_2001/2005/z462928_s.pdf zu finden oder können beim Autor angefordert werden. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Vers une méthode d'evaluation comparée de mécanismes de regroupements de pixels : Application à la décomposition en composantes connexes et à la croissance de régions pour l'utilisation dans un système de vision robotique temps réel (2003)

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