gebhart/patrepeval huggingface dataset:
The effect of pancreatic and intestinal venous blood on hepatic atrophy and compensatory hyperplasia in the rat. (1989)

Hepatotrophic effect of pancreatic and intestinal venous blood was studied in rats with mesocaval or distal splenocaval shunt following ligation of a branch of the portal vein supplying 70% of liver mass. Because 2/3 of liver mass was deprived of portal flow the nonligated liver lobes were not hypoperfused due to shunt procedure. During the first three postoperative days the DNA synthesis, mitotic index, and changes in relative weights were measured in both ligated (atrophied) and nonligated (compensatory hyperplasia) parts of the liver. It was found, that the restorative capacity of the liver existed in rats with selective portasystemic shunts. The stimulus to growth was greater in lobes supplied by intestinal venous blood compared to those perfused by pancreatic effluent. The increase in DNA synthesis occurred in lobes undergoing atrophy and the intensity of this response was also dependent on type of shunt since recirculation of intestinal blood by way of the hepatic artery inhibited atrophy to a greater extent than pancreatic venous effluent. Although the patency of arterial branches was confirmed the ligated lobes showed necrotic lesions. Systemic recirculation of intestinal venous blood far more inhibited necrosis than pancreatic venous blood.
Immunohistochemical pattern of p53 is a measure of TP53 mutation burden and adverse clinical outcome in myelodysplastic syndromes and secondary acute myeloid leukemia (2016)

Myelodysplastic syndromes (MDS) are genetically diverse malignancies with peripheral cytopenias, dysplastic hematopoiesis, and increased risk for acute myeloid leukemia (AML) transformation. Recent investigations indicate that somatic, myeloid-specific gene mutations refine clinical staging to alter estimates of overall survival (OS), and should be included in current risk stratification models.1 Hence, the identification of these mutations and corresponding protein expression levels has increasing clinical utility. TP53 mutations are found in 5–10% of MDS patients, are enriched in patients with isolated del(5q), complex cytogenetics, or MDS with fibrosis (MDS-F), and are associated with an overall worse prognosis.1–5 Next-generation sequencing (NGS) is a valuable ancillary tool, however, the technology may not be economically feasible for routine community use. Alternatively, immunohistochemistry (IHC) is fast, reproducible, and cost effective for routine laboratory use. In this study, we explore the relationship between p53 expression and TP53 gene mutation in MDS and acute myeloid leukemia with myelodysplasia-related changes (AML-MRC). Additionally, we investigate correlations between p53 expression and clinical characteristics, including TP53 mutation variant allele frequency (VAF), myeloblast percentage, cytogenetic characteristics and outcome.
Insulin receptor function in fibroblasts from patients with leprechaunism. Differential alterations in binding, autophosphorylation, kinase activity, and receptor-mediated internalization. (1988)

Insulin receptor function was examined in cultured skin fibroblasts from three patients with leprechaunism (Ark-1, Minn-1, and Can-1), a rare syndrome of severe insulin resistance and neonatal growth retardation. All three patients cell lines demonstrated insulin binding less than 15% of control. This was primarily due to reduced affinity of the receptor in Can-1 and due to reduced number of receptors in the other two cell lines (Ark-1 and Minn-1). When expressed as a fraction of total insulin bound, the percentage of cell-associated insulin internalized and degraded did not differ between the patient cell lines and the controls. However, chloroquine, which inhibited degradation by 50% in the control cells, had no effect in the cells from the patients. When normalized to insulin binding, insulin receptor autophosphorylation was normal in cells from Can-1, but reduced in those of Ark-1 and Minn-1. In contrast, the receptor-associated tyrosine kinase activity toward exogenous substrates was decreased in all three patient cell lines. These results suggest that leprechaunism is a biochemically heterogenous disease associated with a variety of alterations in receptor function. Cells from Ark-1 and Minn-1 exhibit parallel alterations in receptor autophosphorylation and kinase activity. Cells from Can-1 demonstrate normal receptor autophosphorylation but reduced kinase activity, thus displaying a unique form of a mutant insulin receptor. Despite reduced kinase activity, all three cell lines exhibit normal rates of insulin internalization, but decreased lysosomal-mediated degradation. Our data imply that receptor autophosphorylation and kinase activity may be regulated separately and that kinase activity may be linked to insulin degradation, but not necessarily internalization.
Suivi agroclimatique des cultures par Meteosat et NOAA en zone sahelienne (1988)

National audience
Identification of a Bacillus subtilis secretion mutant using a  -galactosidase screening procedure (1995)

High-level synthesis of exportable beta-galactosidase (LacZ) fusion proteins in Bacillus subtilis results in a lethal phenotype, and has been suggested as a tool for the selection of secretion mutants. We tested a plasmid-based, inducible lacZ fusion gene system for this purpose, but frequent mutations in cis, which reduced expression of the fusion gene, forced abandonment of the induction-selection strategy. Instead, after modification of the indicator plasmid, a screening procedure for increased basal LacZ activity levels was adopted. This led to the identification of a conditional B. subtilis secretion mutant after nitrosoguanidine mutagenesis. At 42 degrees C, but not at 30 degrees C, this mutant displayed extreme growth retardation when the LacZ fusion protein was produced, and and was also defective in the secretion of subtilisin Carlsberg. The processing kinetics and secretion of a subtilisin Carlsberg-alkaline phosphatase fusion derivative were found to be defective specifically at the non-permissive temperature. The secretion defect was not linked to the secA/div locus.
Automating Operational and Science Analysis Processes with the Autonomous Sciencecraft Constellation (2002)

The Autonomous Sciencecraft Constellation-Techsat 21 mission is a NASA New Millennium Program mission selected for flight in 2004. ASC will autonomously perform science analyses of X-band radar data, while in Earth orbit. Additional information is contained in the original extended abstract.
Ion optical considerations of a quadrupole–octapole lens system for varying mass range on a simultaneous detector (1989)

Abstract The sensitivity and mass resolution of a conventional double‐focusing mass spectrometer equipped with an array detector are limited by the fixed range of masses that can be detected simultaneously. This paper describes ion‐optical properties of a new lens system for varying the relative mass range on the simultaneous detector.
Synthesis and Biological Evaluation of 6‐Aryl‐6H‐pyrrolo[3,4‐d]pyridazine Derivatives: High‐Affinity Ligands to the α<sub>2</sub>δ Subunit of Voltage Gated Calcium Channels. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Sphenoid Sinus Mucocele: A Rare Complication of Transsphenoidal Hypophysectomy (2001)

Only seven cases of a sphenoid mucocele occurring after transsphenoidal hypophysectomy have been previously reported in the world literature. In this article, we report a new case, which occurred in a 67-year-old man. The sphenoid sinus mucocele developed 12 years following transsphenoidal hypophysectomy and adjunctive radiotherapy. The patient was successfully managed with incision and drainage. Although transsphenoidal hypophysectomy is a common operation, this particular complication appears to be rare or at least under-reported. Sphenoid sinus mucocele deserves consideration in the differential diagnosis of a sphenoidal parasellar mass in a patient who has undergone an earlier transsphenoidal hypophysectomy.
Supplementary Methods from HSP90 Inhibitor–SN-38 Conjugate Strategy for Targeted Delivery of Topoisomerase I Inhibitor to Tumors (2023)

&lt;p&gt;Plasma stability assay&lt;/p&gt;
Generalization of processing gain definition and selection of spread spectrum signals (2003)

It is shown that optimization of a data modulation technique in a spread spectrum communication system requires generalization of processing gain definition because conventionally defined processing gain is not always a sufficient parameter. Introduction of the generalized parameter, relative effective processing gain, allows selection of the signals with maximum jam resistance and multiple access capacity.
High Stability Self-Injection Locked Laser (2019)

We demonstrate a miniature self-injection locked 1550 nm laser characterized with Allan deviation of 10−12 at 1s integration time. The stability is achieved using a composite crystalline monolithic optical resonator. The thermal stabilization on the order of 10 μK at 1s is achieved using a standard thermo-electric element. © 2019 The Author(s)
Development of an ultra-miniaturized inertial measurement unit WB-3 for human body motion tracking (2010)

Real-time tracking of human body motion is an important technology in synthetic environments, robotics, and other human-computer interaction applications. This paper presents an ultra-miniaturized inertial measurement unit (IMU) named WB-3 for real-time attitude estimation of human limb segments. The WB-3 IMU is provided with a 32-bit microcontroller and 9-axis inertial sensors (miniaturized MEMS accelerometer, gyroscope and magnetometer). The quaternion-based Extended Kalman Filter (EKF) was implemented for the sensor fusion to retrieve the attitude of the human segment. An upper body motion capture system with 12 WB-3 IMUs was elaborated for tracking human movements in real time scenarios.
Noncontact nanolithography using the atomic force microscope (1998)

We have demonstrated that the atomic force microscope (AFM) operating in air may be used to pattern narrow features in resist in a noncontact lithography mode. A micromachined AFM cantilever with an integrated silicon probe tip acts as a source of electrons. The field emission current from the tip is sensitive to the tip-to-sample spacing and is used as the feedback signal to control this spacing. Feature sizes below 30 nm have been patterned in 65-nm-thick resist and transferred through reactive ion etching into the silicon substrate. We show that the same AFM probe used for noncontact patterning can be used to image the sample. In addition to eliminating the problem of tip wear, this noncontact system is easily adapted to multiple-tip arrays where each cantilever has an integrated actuator to adjust the probe height.
Perception of American English /r/ and /l/ by Mandarin speakers: Influences of phonetic identification and category goodness (1998)

Studies in speech perception show a perceptual magnet effect for listeners which is characterized by shrunken perceptual distances near excellent exemplars of phonetic categories and stretched distances near poor exemplars. This study extended this work by examining the influence of Mandarin speakers’ phonetic identification and category goodness on their perception of American English /r/ and /l/. Eighteen /ra/ and /la/ tokens were used that varied F2 and F3 frequencies. Listeners identified stimuli as Mandarin /u/, /m/, or /l/, provided goodness ratings for them, and rated the similarity of all stimulus pairs. Multidimensional scaling analyses of similarity ratings exhibited that the perceptual ‘‘map’’ for Mandarin speakers differs substantially from that of American speakers [Iverson and Kuhl, J. Acoust. Soc. Am. (1996)] listening to the same stimuli. The results indicate that (1) Mandarin speakers perceived /u/ and /l/ in the space, (2) perceptual distance was shrunk near the best exemplars of phonetic categories and stretched near the category boundary, (3) variations of F2 were more important than F3, and (4) individual differences in /l/ identification corresponded to a degree of shrinking near the best exemplars of the /l/ category. Results indicate that listeners use their native-language representations in the perception of a non-native language.
An explicit Hybrid Model Predictive Control Strategy for Intravenous Anaesthesia (2015)

The paper describes a strategy for the control of intravenous depth of anaesthesia for the induction and maintenance phase. Based on the anaesthesia model, described by a piece-wise affine system, a hybrid model predictive control problem results, which is solved explicitly via the solution of a novel multi-parametric mixed integer quadratic programming algorithm. The control strategy is successfully tested on a set of 7 patients.
Fast H.264/AVC stream joiner for interactive free view-area multivision video (2011)

With the spread of high-definition video devices, and with the advance of digital broadcasting systems and video portal services in the Internet domains, numerous high-definition video presentations become available in everyday life. Under these circumstances, the desire of people to enjoy video contents in new ways had grown. This paper proposes a new multivision video provisioning system that enables numerous users to access any view area with any desired resolution interactively. The basic idea is that the partial area (tile)-based pre-coded video streams are stored in advance. These multiple streams are joined dynamically and delivered based on the user's view-area position. In this paper, the details of H.264/AVC tile-based video coding and a fast tile stream joiner scheme are presented. Simulation experiments and our practical implementation demonstrate the feasibility and effectiveness of our proposal.
Complement C3a and C5a receptors promote GVHD by suppressing mitophagy in recipient dendritic cells (2018)

Graft-versus-host disease (GVHD) is a major complication of allogeneic hematopoietic cell transplantation (HCT). DCs play critical roles in GVHD induction. Modulating autophagy represents a promising therapeutic strategy for the treatment of immunological diseases. Complement receptors C3aR/C5aR expressed on DCs regulate immune responses by translating extracellular signals into intracellular activity. In the current study, we found that C3aR/C5aR deficiency enhanced ceramide-dependent lethal mitophagy (CDLM) in DCs. Cotransfer of host-type C3aR-/-/C5aR-/- DCs in the recipients significantly improved GVHD outcome after allogeneic HCT, primarily through enhancing CDLM in DCs. C3aR/C5aR deficiency in the host hematopoietic compartment significantly reduced GVHD severity via impairing Th1 differentiation and donor T cell glycolytic activity while enhancing Treg generation. Prophylactic treatment with C3aR/C5aR antagonists effectively alleviated GVHD while maintaining the graft-versus-leukemia (GVL) effect. Altogether, we demonstrate that inhibiting C3aR/C5aR induces lethal mitophagy in DCs, which represents a potential therapeutic approach to control GVHD while preserving the GVL effect.
A Nanomechanical Investigation of Engineered Bone Tissue Comparing Elastoplastic and Viscoelastoplastic Modeling (2017)

It is common practice to implement the elastoplastic Oliver and Pharr (OP) model to investigate the spatial and temporal variations of mechanical properties of engineered bone. However, the viscoelastoplastic (VEP) model may be preferred being envisaged to provide additional insights into the regeneration process, as it allows evaluating also the viscous content of bone tissue. In this work, the elastic modulus (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M1"><mml:mrow><mml:msub><mml:mrow><mml:mi>E</mml:mi></mml:mrow><mml:mrow><mml:mi>R</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>), contact hardness (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M2"><mml:mrow><mml:msub><mml:mrow><mml:mi>H</mml:mi></mml:mrow><mml:mrow><mml:mi>C</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>), hardness (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M3"><mml:mrow><mml:mi>H</mml:mi></mml:mrow></mml:math>), and viscosity index (<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" id="M4"><mml:mrow><mml:msub><mml:mrow><mml:mi>η</mml:mi></mml:mrow><mml:mrow><mml:mi>Q</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>) of newly formed bone tissue regenerated at 4 and 12 weeks from the implantation of a macroporous hydroxyapatite scaffold in a rabbit femoral critical-size model were addressed and compared to the mechanical properties of preexisting bone. Indentation curves were fitted with both the OP and VEP models. The VEP model outlined a wider gap between the mechanical properties of native and regenerated tissue when compared to the OP model. In addition, the VEP model indicated an increase of the viscosity index from 4 to 12 weeks, supporting the evidence of a still active regeneration process. The reported results confirmed the higher ability of VEP model compared to the more diffused OP model to provide important insights into bone mechanical properties, also during the bone regeneration process.
Energy harvesting optical modulators with sub-attojoule per bit electrical energy consumption (2021)

The light input to a semiconductor optical modulator can constitute an electrical energy supply through the photovoltaic effect, which is unexploited in conventional modulators. In this work, we leverage this effect to demonstrate a silicon modulator with sub-aJ/bit electrical energy consumption at sub-GHz speeds, relevant for massively parallel input/output systems such as neural interfaces. We use the parasitic photovoltaic current to self-charge the modulator and a single transistor to modulate the stored charge. This way, the electrical driver only needs to charge the nano-scale gate of the transistor, with attojoule-scale energy dissipation. We implement this 'photovoltaic modulator' in a monolithic CMOS platform. This work demonstrates how close integration and co-design of electronics and photonics offers a path to optical switching with as few as 500 injected electrons and electrical energy consumption as low as 20 zJ/bit, achieved only by recovering the absorbed optical energy that is wasted in conventional modulation.
Comparative proteomics of human endothelial cell caveolae and rafts using two‐dimensional gel electrophoresis and mass spectrometry (2004)

The human endothelial cell plasma membrane harbors two subdomains of similar lipid composition, caveolae and rafts, both crucially involved in various essential cellular processes like transcytosis, signal transduction and cholesterol homeostasis. Caveolin-enriched membranes, isolated by either cationic silica or buoyant density methods, were explored by comparing large series of two-dimensional (2-D) maps and subsequent identification of over 100 protein spots by matrix-assisted laser desorption/ionization (MALDI) peptide mass fingerprinting. Improved representation and identification of membrane proteins and valuable information on various post-translational modifications was achieved by the presented optimized procedures for solubilization, destaining and database searching/computing. Whereas the cationic silica purification yielded predominantly known endoplasmic reticulum residents, the cold-detergent method yielded a large number of known caveolae residents, including caveolin-1. Thus, a large part of this subproteome was established, including known (trans-)membrane, signal transduction and glycosyl phosphatidylinositol (GPI)-anchored proteins. Several predicted proteins from the human genome were isolated for the first time from biological samples, including SGRP58, SLP-2, C8ORF2, and XRP-2. These findings and various optimized procedures can serve as a reference to study the differential composition of endothelial cell caveolae and rafts, known to be involved in pathologies like cancer and cardiovascular disease.
Exercise Hyperventilation in Chronic Heart Failure is Not Caused by Systemic Lactic Acidosis (2005)

In heart failure VE/VCO(2) slope and low arterial pCO(2) at peak exercise are not related to the degree of systemic lactic acidosis. Lactic acidosis is therefore not a plausible mechanism of exercise induced hyperventilation.
Crystal Structure of a New Pyrrolo[1,2-a][1,10]phenanthroline Derivative (2007)

The compound diisopropyl 11-(4-phenylbenzoyl)-pyrrolo[1,2-a][1,10]phenanthroline-9,10-dicarboxylate 1 contains a pyrrole ring bearing three bulky substituents. X-ray analysis was undertaken to establish the effect of this substitution on the helical distortion reported previously for molecules in this class. Compound 1 crystallizes in the space group P1 with a = 12.0300(2)Å, b = 16.1897(3)Å, c = 17.0965(4)Å, α = 109.934(1)°, β = 102.655(1)°, γ = 99.678(1)° and Z = 4. The extent of helical distortion is significant and comparable in the two crystallographically independent molecules, the average angle between the pyrrole ring plane and the terminal pyridine ring being ∼20°.
Monte Carlo simulation of stress-induced leakage current by hopping conduction via multi-traps in oxide (2002)

For the first time a new simulation method applicable to a stress-induced leakage current (SILC) by successive hopping conduction via multi-traps is presented. This method describes the electron hopping process and trap distribution microscopically. A rate-limiting process of hopping conduction is found to be an electrode-to-trap tunneling, which causes large electric field and temperature dependences of the current.
Conjugate heat transfer modeling of a turbine vane endwall with thermal barrier coatings (2019)

ABSTRACT Advanced cooling techniques involving internal enhanced heat transfer and external film cooling and thermal barrier coatings (TBCs) are employed for gas turbine hot components to reduce metal temperatures and to extend their lifetime. A deeper understanding of the interaction mechanism of these thermal protection methods and the conjugate thermal behaviours of the turbine parts provides valuable guideline for the design stage. In this study, a conjugate heat transfer model of a turbine vane endwall with internal impingement and external film cooling is constructed to document the effects of TBCs on the overall cooling effectiveness using numerical simulations. Experiments on the same model with no TBCs are performed to validate the computational methods. Round and crater holes due to the inclusion of TBCs are investigated as well to address how film-cooling configurations affect the aero-thermal performance of the endwall. Results show that the TBCs have a profound effect in reducing the endwall metal temperatures for both cases. The TBC thermal protection for the endwall is shown to be more significant than the effect of increasing coolant mass flow rate. Although the crater holes have better film cooling performance than the traditional round holes, a slight decrement of overall cooling effectiveness is found for the crater configuration due to more endwall metal surfaces directly exposed to external mainstream flows. Energy loss coefficients at the vane passage exit show a relevant negative impact of adding TBCs on the cascade aerodynamic performance, particularly for the round hole case.
Quantification of Small Cell Numbers with a Microchannel Device (2008)

The ability to precisely quantify rare populations of cells has become an essential first step of many cell-based assays in stem cell research. Since current devices for cell quantification require relatively high cell concentrations and/or absolute cell numbers, we have developed a microchannel-based device, allowing precise quantification of limiting cell numbers/concentrations. We anticipate this device will serve as an important tool to overcome a practical obstacle in stem cell research.