gebhart/patrepeval huggingface dataset:
A phase II study of MK-2206, an AKT inhibitor, in uterine serous carcinoma (2022)

Uterine serous carcinoma (USC) is an uncommon subtype of endometrial cancer with a poor prognosis. USCs have genomic alterations in the PI3K pathway. A prior phase II study of AKT inhibitor MK-2206 (an allosteric AKT inhibitor, primarily affecting AKT1 and AKT2) in endometrial cancers resulted in progression-free survival (PFS) of ≥6 months in five out of seven patients with USC. To further assess the activity of MK-2206 in USC, we designed a phase II, single-stage assessment of MK-2206 in patients with advanced or recurrent high-grade serous endometrial cancer, who had received up to two lines of prior therapy. MK-2206 (135 mg) was administered orally once per week, in continuous 28-day cycles. Fourteen patients received treatment. The most common treatment-related adverse events were diarrhea (36%), acneiform rash (36%), nausea (29%), fatigue (29%), and hyperglycemia (21%); most events were grade 1-2. One confirmed partial response was observed in a patient who was also alive and progression-free at 6 months. One additional patient was alive and progression-free at 6 months. The clinical benefit rate was 14.3% (95% CI: 1.8 to 42.8). Five patients had stable disease (35.7%) and seven had progressive disease (50%); one was unevaluable. Median PFS was 2 months (95% CI: 1.6 to 4.4) and median overall survival was 6.4 months (95% CI: 5.1 to not reached). In summary, MK-2206 had limited activity in USC, although a few patients achieved sustained progression-free intervals in this study and in the previously reported phase II trial of MK-2206. Further investigations are needed to identify features associated with response.
Reduced offsets for two-level multi-valued logic minimization (1990)

The approaches to two-level logic minimization can be classified into two groups: those that use tautology for expansion of cubes and those that use the offset. Tautology based schemes are generally slower and often give somewhat inferior results, because of a limited global picture of the way in which the cube can be expanded. If the offset is used, usually the expansion can be done quickly and in a more global way because it is easier to see effective directions of expansion. The problem with this approach is that there are many functions that have a reasonable size onset and don't care set but the offset is unreasonably large. It was recently shown that for the minimization of such Boolean functions, a new approach using reduced offsets, provides the same global picture and can be computed much faster. In this paper we extend reduced offsets to logic functions with multi-valued inputs.
Dataset for Temperature insensitive fiber interferometry (2019)

Data supporting the paper Zhu, Wenwu ; Numkam Fokoua, Eric ; Chen, Yong ; Bradley, Thomas ; Petrovich, Marco ; Poletti, Francesco ; Zhao, Mingshan ; Richardson, David ; Slavík, Radan. / Temperature insensitive fiber interferometry. In: Optics Letters. 2019
A 2.5-GHz 1-V High Efficiency CMOS Power Amplifier IC with a Dual-Switching Transistor and Third Harmonic Tuning Technique (2019)

This paper presents a 2.5-GHz low-voltage, high-efficiency CMOS power amplifier (PA) IC in 0.18-µm CMOS technology. The combination of a dual-switching transistor (DST) and a third harmonic tuning technique is proposed. The DST effectively improves the gain at the saturation power region when the additional gain extension of the secondary switching transistor compensates for the gain compression of the primary one. To achieve high-efficiency performance, the third harmonic tuning circuit is connected in parallel to the output load. Therefore, the flattened drain current and voltage waveforms are generated, which in turn reduce the overlapping and the dc power consumption significantly. In addition, a 0.5-V back-gate voltage is applied to the primary switching transistor to realize the low-voltage operation. At 1 V of supply voltage, the proposed PA has achieved a power added efficiency (PAE) of 34.5% and a saturated output power of 10.1 dBm.
Plasma antioxidants and phospholipids and brain imaging biomarkers among non‐demented older adults (2021)

Abstract Background Previous studies have linked dietary fatty acids and antioxidants to dementia risk and cognitive decline. The relationships of objective markers of fatty acid and antioxidant intakes with brain imaging biomarkers remain uncertain. Method We assessed the associations of antioxidants and phospholipids in plasma, collected in 2000‐2002, with brain amyloid‐ß deposition on PET scans and hippocampal and white matter lesion volume on MRIs in 2009 among 193 participants of the Ginkgo Evaluation of Memory Study who were free of clinical dementia. We used multivariable‐adjusted and inverse‐probability‐weighted robust linear regression models. We measured antioxidants by organic phase extraction followed by chromatographic analysis and individual plasma phospholipids (as a percentage of total plasma phospholipid fatty acids) by gas chromatography with flame ionization detection. Result A total of 20 participants (10%) had mild cognitive impairment at baseline and 134 participants (69%) used either multivitamin, vitamin A or β‐carotene, or vitamin E supplements ( Table 1 ). Higher plasma retinol,α‐tocopherol, and total vitamin E were related to higher future amyloid‐ß deposition ( Table 2 ). Higher α‐tocopherol and total vitamin E were also related to less white matter lesion volume. Carotenoids were not significantly related to any of the brain imaging biomarkers. Higher concentrations of the saturated fatty acid margaric acid (17:0) were associated with more amyloid‐ß deposition (adjusted difference per 1 SD higher margaric acid: 0.10 standardized uptake value ratio; 95% CI: 0.02, 0.19) and smaller hippocampal volume ( Table 3 ). In contrast, higher concentrations of the saturated fatty acid behenic acid (22:0) were associated with less white matter lesion volume. Higher oleic acid (18:1n‐9c, a major monounsaturated fatty acid), was related to more hippocampal volume. Higher concentrations of the n‐3 polyunsaturated fatty acid docosahexaenoic acid (22:6n‐3c) were associated with more amyloid‐ß deposition, while higher concentrations of linoleic acid (18:2n‐6cc; a major n‐6 polyunsaturated fatty acid) were associated with less amyloid‐ß deposition (adjusted difference per 1 SD higher linoleic acid: ‐0.10 standardized uptake value ratio; 95% CI:‐0.19, ‐0.01). Conclusion Specific antioxidants and phospholipids may be associated with brain imaging biomarkers, a hypothesis that requires formal testing in long‐term intervention studies and that represents a possible preventive intervention,
&lt;title&gt;Mechanisms of multiple shot bulk damage of silicate glasses with and without conditions of multiphoton absorption&lt;/title&gt; (1995)

Accumulation effect in silicate glasses under single frequency laser radiation (0.53 and 1.06 micrometers ) has been investigated. It is shown that this effect in lead silicate glasses at 0.53 micrometers is the result of the multiphoton matrix ionization, the accumulation of color centers and radiation absorption by them, and the decrease of thermal self- focusing threshold. However, under radiation at 1.06 micrometers in the same materials the multiphoton ionization and color centers formation are not observed. It is established that in this case accumulation effect is connected with densification of glasses in the interaction bulk. This densification is the result of the action of large electrostrictional pressure. It leads to the modification of physical properties of glasses without electronic excitations and the decrease of the self-focusing threshold. In this connection, the accumulation effect takes place only if electrostrictional pressure exceeds threshold value of pressure required to densification of glasses.
Optical neuromorphic processing with Kerr microcombs: Scaling the network in size and speed to the PetaOp regime (2022)

Abstract Convolutional neural networks (CNNs), inspired by biological visual cortex systems, are a powerful category of artificial neural networks that can extract the hierarchical features of raw data to greatly reduce the network parametric complexity and enhance the predicting accuracy. They are of significant interest for machine learning tasks such as computer vision, speech recognition, playing board games and medical diagnosis [1–7]. Optical neural networks offer the promise of dramatically accelerating computing speed to overcome the inherent bandwidth bottleneck of electronics. Here, we demonstrate a universal optical vector convolutional accelerator operating beyond 10 Tera-OPS (TOPS - operations per second), generating convolutions of images of 250,000 pixels with 8-bit resolution for 10 kernels simultaneously — enough for facial image recognition. We then use the same hardware to sequentially form a deep optical CNN with ten output neurons, achieving successful recognition of full 10 digits with 900 pixel handwritten digit images with 88% accuracy. Our results are based on simultaneously interleaving temporal, wavelength and spatial dimensions enabled by an integrated microcomb source. We show that this approach is scalable and trainable to much more complex networks for demanding applications such as unmanned vehicle and real-time video recognition.
Retinal pigment epithelial cell expression of active Rap 1a by scAAV2 inhibits choroidal neovascularization (2016)

To test the hypothesis that increased Rap1a activity specifically in retinal pigment epithelial cells resists choroidal neovascularization (CNV), self-complementary adeno-associated virus 2 (scAAV2) with RPE65-promoter-driven GFP vectors were generated and introduced subretinally into Rap1b -deficient mice. Six-week-old mice that received subretinal control (scAAV2-Con) or constitutively active Rap1a (scAAV2-CARap1a) showed strong GFP at the 5 × 10 8 viral particle/μl dose 5 weeks later without altering retinal morphology or function. Compared to scAAV2-Con- or phosphate-buffered saline (PBS)-injected, eyes injected with scAAV2-CARap1a had increased Rap1 in retinal pigment epithelial (RPE)/choroidal lysates and a significant reduction in CNV volume 7 days after laser, comparable to eyes that received intravitreal anti-VEGF versus IgG control. scAAV2-CARap1a-, but not anti-VEGF-, injected eyes had increased pan-cadherin in RPE/choroids. In cultured RPE cells, increased active Rap1a inhibited TNFα-induced disassociation of junctional pan-cadherin/β-catenin complexes, increased transepithelial electrical resistance through an interaction of β-catenin with phosphorylated scaffold protein, IQGAP1, and inhibited choroidal endothelial cell (CEC) transmigration of an RPE monolayer. This evidence shows that increased Rap1a activity specifically in RPE cells is sufficient to reduce CEC transmigration and CNV and involves IQGAP1-mediated protection of RPE junctional complexes.
Contrôle d'un système multi-CNN via le cap magnétique du smartphone pour la reconnaissance de scènes indoor (2022)

National audience
MR Imaging Findings of Cortical Dysplasia of the Brain: Correlation with Pathologic Grades and Subtypes. (2003)

Purpose : Cortical dysplasia is known to be of variety of MR imaging findings. We attempted to classify MR imaging findings of cortical dysplasia into several types and to correlate those with histopathologic grades and subtypes. Materials and Methods : Preoperative MR images of 97 patients with pathologically-proven cortical dysplasia were retrospectively reviewed with knowledge of the diagnosis and operative sites. The patients were divided into MR-positive and MR-negative groups based on the presence or absence of MR imaging abnormalities. In MR-positive group, MR imaging features were arbitrarily classified into four types (atrophic, cortical-band, inward-rounding, and nonspecific types) on the basis of size of the gyrus and adjacent CSF space, cortical thickness, signal intensity of the subcortical white matter, and blurring of the gray-white matter junction. The pathologic findings were also retrospectively reviewed without knowledge of MR imaging findings and divided into three grades (mild, moderate, and severe) and two subtypes (nonballoon-cell and balloon-cell). Pathologic grades and subtypes we re compared between MR-positive and MR-negative groups. Four MR types of the MR-positive group were correlated with the pathologic grades and subtypes. Results : MR-positive and MR-negative groups consisted of 39 (40%) and 58 (60%) patients, respectively. Of the MR-positive group, atrophic type was seen in 13 patients (33 %), cortical-band type in 9 (23%), inward-rounding type in 9 (23%), and nonspecific type in 8 (21%). There was no significant difference in the pathologic grades between MR-positive and MR-negative groups, although MR-positive group tended to have higher pathologic grades than MR-negative group did. Balloon-cell subtype was found significantly higher in MR-positive group than in MR-negative group (p
Trichodysplasia spinulosa in a child: Identification of trichodysplasia spinulosa‐associated polyomavirus in skin, serum, and urine (2019)

A 6-year-old girl with a history of chronic immunosuppression following small bowel and colon transplantation for tufting enteropathy presented with a diffuse, facial-predominant eruption composed of pink-to-skin-colored papules with central white dystrophic spicules. Histology from a punch biopsy and polymerase chain reaction (PCR) from plucked spicules confirmed a diagnosis of trichodysplasia spinulosa (TS). Additional molecular studies identified several strains of the trichodysplasia spinulosa-associated polyomavirus infecting multiple tissues of the patient, confirming the systemic nature of trichodysplasia spinulosa infections.
Synthesis and characterization of tetrafunctional lactic acid oligomers: A potentialin situ forming degradable orthopaedic biomaterial (2001)

Tetrafunctional lactic acid oligomers with low molecular weight ethylene glycol cores were synthesized and characterized to assess their applicability to orthopaedics. Utilizing a visible light photoinitiating system, these oligomers polymerize within minutes to form highly crosslinked networks and, thus, have potential for in situ formation. Varying the oligomer structure readily alters the physical properties of the resultant polymer networks. For instance, mechanical properties were highly dependent on the number of lactic acid and ethylene glycol units in the oligomer backbone. Additionally, polymer mass loss ranged from ∼30 to 60% within 8 weeks of degradation time depending on the oligomer chemistry. Mechanical properties decreased with degradation of these polymers, indicating a bulk degradation mechanism. Finally, scaffolds with a controlled architecture were fabricated from these oligomers that show potential for tissue-engineering applications. © 2001 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 39: 683–692, 2001
High average power laser using a transverse flowing liquid host (2023)

A laser includes an optical cavity. A diode laser pumping device is located within the optical cavity. An aprotic lasing liquid containing neodymium rare earth ions fills the optical cavity. A circulation system that provides a closed loop for circulating the aprotic lasing liquid into and out of the optical cavity includes a pump and a heat exchanger.
Low Complexity Optimization for Line-of-Sight RIS-Aided Holographic Communications (2023)

The synergy of metasurface-based holographic surfaces (HoloS) and reconfigurable intelligent surfaces (RIS) is considered a key aspect for future communication networks. However, the optimization of dynamic metasurfaces requires the use of numerical algorithms, for example, based on the singular value decomposition (SVD) and gradient descent methods, which are usually computationally intensive, especially when the number of elements is large. In this paper, we analyze low complexity designs for RIS-aided HoloS communication systems, in which the configurations of the HoloS transmitter and the RIS are given in a closed-form expression. We consider implementations based on diagonal and non-diagonal RISs. Over line-of-sight channels, we show that the proposed schemes provide performance that is close to that offered by complex numerical methods.
Reversible room temperature ammonia gas absorption in pore water of microporous silica–alumina for sensing applications (2018)

The high reversible ammonia adsorption capacity of pore water in a microporous silica–alumina material.
Wireless power transfer through metallic barriers enclosing a harsh environment; feasibility and preliminary results (2016)

Modern sensor networks are evolving toward wireless interfaces for both power and data transmission. Design of these devices is challenging, especially when both power and data transmission must reach a harsh environment subject to high temperature, high pressure and through thick metallic layers. This paper reports the design and simulation of an inductive power transfer (IPT) system, which characterizes achievable link efficiency. The problem formulation comes from a family of aerospace applications in which electronic must operate at high temperature (500°C) and high pressure (100 bar) and in which a metal casing (15mm thick) isolates the harsh environment from the environment. Specifically, the requirements of booster rockets in aerospace industry are considered. The proposed IPT system was modeled and simulate d using COMSOL. Reported results demonstrate the feasibility of wirelessly transferring power to a high temperature and high pressure zone through various metallic layers using custom electromagnetic link configurations. Power transfer efficiencies of 38% and 15.5% are reported with Titanium and Steel metal booster interfaces at resonance frequencies of 450Hz and 220Hz respectively.
Data from Engineered Adoptive T-cell Therapy Prolongs Survival in a Preclinical Model of Advanced-Stage Ovarian Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Adoptive T-cell therapy using high-affinity T-cell receptors (TCR) to target tumor antigens has potential for improving outcomes in high-grade serous ovarian cancer (HGSOC) patients. Ovarian tumors develop a hostile, multicomponent tumor microenvironment containing suppressive cells, inhibitory ligands, and soluble factors that facilitate evasion of antitumor immune responses. Developing and validating an immunocompetent mouse model of metastatic ovarian cancer that shares antigenic and immunosuppressive qualities of human disease would facilitate establishing effective T-cell therapies. We used deep transcriptome profiling and IHC analysis of human HGSOC tumors and disseminated mouse ID8&lt;sub&gt;VEGF&lt;/sub&gt; tumors to compare immunologic features. We then evaluated the ability of CD8 T cells engineered to express a high-affinity TCR specific for mesothelin, an ovarian cancer antigen, to infiltrate advanced ID8&lt;sub&gt;VEGF&lt;/sub&gt; murine ovarian tumors and control tumor growth. Human CD8 T cells engineered to target mesothelin were also evaluated for ability to kill HLA-A2&lt;sup&gt;+&lt;/sup&gt; HGSOC lines. IHC and gene-expression profiling revealed striking similarities between tumors of both species, including processing/presentation of a leading candidate target antigen, suppressive immune cell infiltration, and expression of molecules that inhibit T-cell function. Engineered T cells targeting mesothelin infiltrated mouse tumors but became progressively dysfunctional and failed to persist. Treatment with repeated doses of T cells maintained functional activity, significantly prolonging survival of mice harboring late-stage disease at treatment onset. Human CD8 T cells engineered to target mesothelin were tumoricidal for three HGSOC lines. Treatment with engineered T cells may have clinical applicability in patients with advanced-stage HGSOC.&lt;/p&gt;&lt;/div&gt;
Automatic Detection of Japanese Compound Functional Expressions and its Application to Statistical Dependency Analysis (2007)

日本語には, 「にあたって」や「をめぐって」のように, 2つ以上の語から構成され, 全体として1つの機能的な意味をもつ機能表現という表現が存在する.一方, この機能表現に対して, それと同一表記をとり, 内容的な意味をもつ表現が存在することがある.そして, この表現が存在することによって, 機能表現の検出は困難であり, 機能表現を正しく検出できる機能表現検出器が必要とされている.そこで, 本論文では, 日本語機能表現を機械学習を用いて検出する手法を提案する.提案手法では, Support Vector Machine (SVM) を用いたチャンカーYam Chaを利用して, 形態素解析結果を入力とする機能表現検出器を構築する.具体的には, 形態素解析によって得られる形態素の情報と, 機能表現を構成している形態素の数の情報, 機能表現中における形態素の位置情報, 機能表現の前後の文脈の情報を学習・解析に使用することにより, F値で約93%という高精度の検出器を実現した.さらに, 本論文では, 機能表現検出器の解析結果を入力として, 機能表現を考慮した係り受け解析器を提案する.提案手法では, Support Vector Machine (SVM) に基づく統計的係り受け解析手法を利用して, 機能表現を考慮した係り受け解析器を構築する.具体的には, 京都テキストコーパスに対して, 機能表現の情報を人手で付与し, 機能表現の情報を基に文節の区切りや係り先の情報を機能表現を考慮したものに変換した.そして, SVMに基づく統計的係り受け解析の学習・解析ツールCabo Chaを用いて, 変i換したデータを学習し, 機能表現を考慮した係り受け解析を実現した.評価実験では, 従来の係り受け解析手法よりもよい性能を示すことができた.
Biomechanical Changes of Repair Tissue after Autologous Chondrocyte Implantation at Long-Term Follow-Up (2020)

<i>Objective</i>. This study aims to describe biomechanical maturation process of repair tissue after cartilage repair with autologous chondrocyte implantation (ACI) at long-term follow-up. <i>Design</i>. After ACI, 40 patients underwent altogether 60 arthroscopic biomechanical measurements of the repair tissue at various time points during an up to 11-year follow-up period. Of these patients, 30 patients had full-thickness cartilage lesions and 10 had an osteochondritis dissecans (OCD) defect. The mean lesion area was 6.5 cm<sup>2</sup> (SD 3.2). A relative indentation stiffness value for each individually measured lesion was calculated as a ratio of repair tissue and surrounding cartilage indentation value to enable interindividual comparison. <i>Results</i>. Repair tissue stiffness improved during approximately 5 years after surgery. Most of the increase in stiffness occurred during the first 2 years. The curvilinear correlation between relative stiffness values and the follow-up time was 0.31 (95% CI 0.07-0.52), <i>P</i> = 0.017. The interindividual variation of the stiffness was high. Lesion properties or demographic factors showed no significant correlation to biomechanical outcome. The overall postoperative average relative stiffness was 0.75 (SD 0.47). <i>Conclusions</i>. Our clinical study describes a biomechanical maturation process of cartilage repair that may continue even longer than expected. A substantial increase in tissue stiffness proceeds for the first two years postoperatively. Minor progression proceeds for even longer. In some repairs, the biomechanical result was equal to native cartilage, suggesting hyaline-type repair. The variation in biomechanical results suggests substantial inconsistency in the structural outcome following ACI.
Design of a multimodal hearing system (2013)

Hearing instruments (HIs) have become context-aware devices that analyze the acoustic environment in order to automatically adapt sound processing to the user?s current hearing wish. However, in the same acoustic environment an HI user can have different hearing wishes requiring different behaviors from the hearing instrument. In these cases, the audio signal alone contains too little contextual information to determine the user?s hearing wish. Additional modalities to sound can provide the missing information to improve the adaption. In this work, we review additional modalities to sound in HIs and present a prototype of a newly developed wireless multimodal hearing system. The platform takes into account additional sensor modalities such as the user?s body movement and location. We characterize the system regarding runtime, latency and reliability of the wireless connection, and point out possibilities arising from the novel approach.
[Complications following cerebral angiography. Report on 4181 cerebral angiographies]. (1980)

Complications of 4181 cerebral angiographies performed from 1973 to 1978 in 2365 patients were analysed. In 13,6% of the patients temporary complications could be observed. In 3,1% temporary neurologic-psychiatric complications occurred, most of them in patients of younger age and in the presence of diffuse cerebrovasuclar disease. There was a permanent damage in 0,21%.