gebhart/patrepeval huggingface dataset:
Stability of motor representations after paralysis (2022)

Neural plasticity allows us to learn skills and incorporate new experiences. What happens when our lived experiences fundamentally change, such as after a severe injury? To address this question, we analyzed intracortical population activity in the posterior parietal cortex (PPC) of a tetraplegic adult as she controlled a virtual hand through a brain-computer interface (BCI). By attempting to move her fingers, she could accurately drive the corresponding virtual fingers. Neural activity during finger movements exhibited robust representational structure similar to fMRI recordings of able-bodied individuals' motor cortex, which is known to reflect able-bodied usage patterns. The finger representational structure was consistent throughout multiple sessions, even though the structure contributed to BCI decoding errors. Within individual BCI movements, the representational structure was dynamic, first resembling muscle activation patterns and then resembling the anticipated sensory consequences. Our results reveal that motor representations in PPC reflect able-bodied motor usage patterns even after paralysis, and BCIs can re-engage these stable representations to restore lost motor functions.
Influence of Sialoadenectomy on Capsaicin-Sensitive"Gastric Defense Mechanism"in Rats. (1991)

Chemical ablation of sensory afferents produced by the treatment with the neurotoxin capsaicin worsened gastric ulcers induced by 50% ethanol in sham- and sialoadenectomized (SALX)-operated rats. Conversely, capsaicin worsened water immersion stress (WIS)-ulcers in SALX, but not those in sham-operated animals. The concomitant removal of two potent antisecretory factors, such as salivary gland containing epidermal growth factor and neuropeptides contained in the sensory afferents, is probably responsible for the enhanced vulnerability of the mucosa in WIS-ulcers.
Polyelectrolyte-Coated Gold Magnetic Nanoparticles for Immunoassay Development: Toward Point of Care Diagnostics for Syphilis Screening (2013)

Immediate response for disease control relies on simple, inexpensive, and sensitive diagnostic tests, highly sought after for timely and accurate test of various diseases, including infectious diseases. Composite Fe3O4/Au nanoparticles have attracted considerable interest in diagnostic applications due to their unique physical and chemical properties. Here, we developed a simple coating procedure for gold magnetic nanoparticles (GMNs) with poly(acrylic acid) (PAA). PAA-coated GMNs (PGMNs) were stable and monodispersed and characterized by Fourier transform-infrared spectroscopy (FT-IR), transmission electron microscopy, UV-visible scanning spectrophotometry, thermogravimetric analysis, and Zetasizer methodologies. For diagnostic application, we established a novel lateral flow immunoassay (LFIA) strip test system where recombinant Treponema pallidum antigens (r-Tp) were conjugated with PGMNs to construct a particle probe for detection of anti-Tp antibodies. Intriguingly, the particle probes specifically identified Tp antibodies with a detection limitation as low as 1 national clinical unit/mL (NCU/mL). An ample pool of 1020 sera samples from three independent hospitals were obtained to assess our PGMNs-based LFIA strips, which exhibited substantially high values of sensitivity and specificity for all clinical tests (higher than 97%) and, therefore, proved to be a suitable approach for syphilis screening at a point-of-care test manner.
ChemInform Abstract: Total Synthesis of (+)‐Gelsedine. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimization of Self Checking FIR filters by means of Fault Injection Analysis (2007)

In this paper the design of a FIR filter with self checking capabilities based on the residue checking is analyzed. Usually the set of residues used to check the consistency of the results of the FIR filter are based of theoretic considerations about the dynamic range available with a chosen set of residues, the arithmetic characteristics of the errors caused by a fault and on the characteristic of the filter implementation. This analysis is often difficult to perform and, to obtain an acceptable fault coverage the set of chosen residues is overestimated, obtained result a and therefore requires that Instead, in this paper we show how using an exhaustive fault injection campaigns allows to efficiently select the best set of residues. Experimental results coming from fault injection campaigns on a 16 taps FIR filter demonstrated that by observing the occurred errors and the detection modules corresponding to different residue has been possible to reduce the number of detection module, while paying a small reduction of the percentage of SEUs that can be detected.
Has brief counselling an impact on the risk factors for cardiovascular disease in 40-year-old men. A three-year follow-up study (2008)

Abstract The metabolic syndrome presents a serious challenge to health professionals. The aim of the present study is to analyze the impact of a brief counselling on cardiovascular risk factors among 40-year-old men. Forty-six males living in north-eastern Helsinki voluntarily completed the follow-up study between 2001 and 2004, and were assessed for clinical risk factors. The mean differences were determined by a paired t-test, and the interaction between groups and time by the F-test with repeated measures ANOVA. After baseline assessment and in 2002, males received a 45 minute nurse-delivered counselling session with self-administered protocol. Cardiovascular risk factors improved significantly (p&lt;0.05) from baseline within months. However, the final measurements obtained after three years showed that almost all risk factors, except the low and high density lipoprotein, tended to revert back to baseline. The profiles were similar in all predictor groups. Brief counselling had an impact on risk factors measured in 2002, but only a partial effect on them in 2004. Conclusive results lead to the idea thatmore collaboration is needed between private health care agencies and official primary health care for ensuring the continuity of improved health habits among middle-aged males.
Hyperstimulation of the immune system as a cause of autoimmune diseases (2020)

The pathogenesis of autoimmune diseases is very complex and multi-factorial. The concept of Mosaics of Autoimmunity was introduced to the scientific community 30 years ago by Y. Shoenfeld and D.A. Isenberg, and since then new tiles to the puzzle are continuously added. This concept specifies general pathological ideas about the multifactorial threshold model for polygenic inheritance with a threshold effect by the action of a number of external causal factors as applied to the field of autoimmunology. Among the external factors that can excessively stimulate the immune system, contributing to the development of autoimmune reactions, researchers are particularly interested in chemical substances, which are widely used in pharmacology and medicine. In this review we highlight the autoimmune dynamics i.e. a multistep pathogenesis of autoimmune diseases and the subsequent development of lymphoma in some cases. In this context several issues are addressed namely, genetic basis of autoimmunity; environmental immunostimulatory risk factors; gene/environmental interaction; pre-clinical autoimmunity with the presence of autoantibodies; and the mechanisms, underlying lymphomagenesis in autoimmune pathology. We believe that understanding the common model of the pathogenesis of autoimmune diseases is the first step to their successful management.
Blind Source Separation of Event-Related EEG/MEG (2016)

Event-related responses and BSS are valuable and popular tools in neuroscience. Correctly designed BSS is an efficient way of identifying artifactual and neural processes from nonstationary event-related data.
Online Multisensor-Multitarget Detection and Tracking (2006)

In this paper we present an online approach for joint detection and tracking for multiple targets with multiple sensors using sequential Monte Carlo (SMC) methods. There are two main contributions in the paper. The first contribution is the extension of the deterministic detection method proposed in our previous publications to a full SMC context in which the track initiation and termination are executed using Bayesian Monte Carlo methods. In effect the dimensions of the particles are variable, and the number of targets can be obtained by the MAP estimation of the dimensions of these particles. The second contribution is the tracking of maneuvering targets without using multiple-model approaches. This can be achieved by recursively estimating the heading directions of the targets, followed by the sampling of the target state along these directions. In effect the use of multiple models to model target maneuvers may not be necessary. Furthermore there is no limitation on which the number of targets that can be simultaneously handled by proposed algorithm. With the employment of multiple sensors, a central-level tracking strategy is adopted, where the observations from all active sensors are fused together for detection and tracking and a set of global tracks is maintained. To further save in the increased computational load arising as a result of the multisensor scenario, only those observations from different sensors that are close to each other according to a distance metric are used for data association. To cope with the data association between the observations from all active sensors and the targets at a given time, we adopt an efficient 2-D data assignment algorithm. Computer simulations demonstrate that the proposed approach is robust in performing joint detection and tracking for multiple maneuvering targets even though the environment is hostile with high clutter rate and low target detection probability
Supplementary Figures 1 - 4 from Efficacy and Mechanism-of-Action of a Novel Superagonist Interleukin-15: Interleukin-15 Receptor αSu/Fc Fusion Complex in Syngeneic Murine Models of Multiple Myeloma (2023)

&lt;p&gt;PDF file - 304K, Growth pattern of 5T33P murine myeloma cells in BM of C57BL/6NHsd mice (S1); ALT-803 activity in murine myeloma models (S2); 5T33P cell apoptosis is not induce culturing with ALT-803 or IFNy (S3); Gating strategy and analysis of donors (S4).&lt;/p&gt;
The Application of Stimuli‐Responsive VEGF‐ and ATP‐Aptamer‐Based Microcapsules for the Controlled Release of an Anticancer Drug, and the Selective Targeted Cytotoxicity toward Cancer Cells (2016)

The synthesis of microcapsules consisting of DNA shells crosslinked by anti‐VEGF (vascular epithelial growth factor) or anti‐ATP (adenosine triphosphate) aptamers and loaded with tetramethylrhodamine‐modified dextran, TMR‐D, and Texas Red‐modified dextran, TR‐D, respectively, as fluorescence labels acting as models for drug loads, is described. The aptamer‐functionalized microcapsules act as stimuli‐responsive carriers for the triggered release of the fluorescent labels in the presence of the overexpressed cancer cell biomarkers VEGF or ATP. The VEGF‐ and ATP‐responsive microcapsules are, also, loaded with the anticancer drug doxorubicin (DOX), in the form of DOX‐functionalized dextran, DOX‐D. The release of DOX‐D from the respective microcapsules proceeds in the presence of VEGF or ATP as triggers. Preliminary cell experiments reveal that the ATP‐responsive DOX‐D‐loaded microcapsules undergo effective endocytosis into MDA‐MB‐231 cancer cells. The ATP‐responsive DOX‐D‐loaded microcapsules incorporated into the MDA‐MB‐231 cancer cells reveal impressive cytotoxicity as compared to normal epithelial MCF‐10A breast cells (50% vs 0% cell death after 24 h, respectively). The cytotoxicity of the ATP‐responsive DOX‐D‐loaded microcapsules toward the cancer cells is attributed to the effective unlocking of the microcapsules by overexpressed ATP, and to the subsequent release of DOX from the dextran backbone under acidic conditions present in cancer cells (pH = 6.2).
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer (2022)

Increased tetrahydrobiopterin (BH4) generated in injured sensory neurons contributes to increased pain sensitivity and its persistence. GTP cyclohydrolase 1 (GCH1) is the rate-limiting enzyme in the de novo BH4 synthetic pathway, and human single-nucleotide polymorphism studies, together with mouse genetic modeling, have demonstrated that decreased GCH1 leads to both reduced BH4 and pain. However, little is known about the regulation of <i>Gch1</i> expression upon nerve injury and whether this could be modulated as an analgesic therapeutic intervention. We performed a phenotypic screen using about 1000 bioactive compounds, many of which are target-annotated FDA-approved drugs, for their effect on regulating <i>Gch1</i> expression in rodent injured dorsal root ganglion neurons. From this approach, we uncovered relevant pathways that regulate <i>Gch1</i> expression in sensory neurons. We report that EGFR/KRAS signaling triggers increased <i>Gch1</i> expression and contributes to neuropathic pain; conversely, inhibiting EGFR suppressed GCH1 and BH4 and exerted analgesic effects, suggesting a molecular link between EGFR/KRAS and pain perception. We also show that GCH1/BH4 acts downstream of KRAS to drive lung cancer, identifying a potentially druggable pathway. Our screen shows that pharmacologic modulation of GCH1 expression and BH4 could be used to develop pharmacological treatments to alleviate pain and identified a critical role for EGFR-regulated GCH1/BH4 expression in neuropathic pain and cancer in rodents.
Analysis of subcellular phosphatidyl choline in developing rabbit lung (1979)

Abstract Phosphatidyl choline is a major lung surfactant. Insufficient development of the surfactant in neonates is often associated with the Respiratory Distress Syndrome. The concentration and fatty acid composition of phosphatidyl choline have not been studied in the subcellular organelles of the developing lung. This study has investigated the development of the concentration and fatty acid composition of phosphatidyl choline in subcellular fractions of 28‐day and 30‐day fetal and maternal New Zealand rabbit lungs. The concentration of total phospholipids in lamellar bodies increased four to five fold from 28‐day fetus to 30‐day fetus which, in turn, was similar to the maternal level. Total phospholipid content increased only about 50% in mitochondria and microsomes. The percentage of phosphatidyl choline among total phospholipids in lamellar bodies increased successively from 60% at 28 days gestation to 84% at 30 days gestation and leveled at 84% in maternal lamellar bodies. Microsomal PC increased steadily from 52% in the 28‐day fetus to 65% in the adult. Analysis of the fatty acid composition of phosphatidyl choline in lamellar bodies confirmed 16∶0 as the major fatty acid, and its content remained constant from 28 days gestation to adult. In contrast, the content of 16∶0 of the microsomal phosphatidyl choline decreased with increasing gestation. Changes of several unsaturated fatty acid components were observed in both lamellar bodies and microsomes in the developing lungs. Maturational development of phosphatidyl choline is reflected in an increase in the concentration of this surfactant, particularly in lamellar bodies, and possibly in remodeling of fatty acid composition in both lamellar bodies and microsomes.
ChemInform Abstract: Synthesis of 2‐(2‐Arylethyl)imidazoles (V) by Direct Alkylation of 1‐( N,N‐Dimethylaminomethyl)‐2‐lithiomethylimidazole (III). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Intravesical Recombinant Tumor Necrosis Factor in the Treatment of Superficial Bladder Cancer: An Eastern Cooperative Oncology Group Study (1995)

We tested and proved the safety of recombinant human tumor necrosis factor given intravesically weekly for 11 weeks (dwell time 2 hours) for the treatment of superficial bladder cancer in 8 men and 1 woman 46 to 87 years old (mean age 69 years). Cohorts of 3 patients received 200, 400 and 1,000 micrograms. recombinant human tumor necrosis factor. The maximal tolerated dose was not achieved. There were 9 episodes of urological symptoms, 8 of flu-like symptoms, 4 of headache and 3 of chest tightness. Hematological and gastrointestinal toxicities were minor, and no renal toxicity was encountered. Recombinant human tumor necrosis factor was safe to administer at doses up to 1,000 micrograms. We hope that recombinant human tumor necrosis factor in conjunction with other antitumor agents will lead to a new, effective treatment for superficial bladder cancer.
Motion-based camera localization system in colonoscopy videos (2021)

Optical colonoscopy is an essential diagnostic and prognostic tool for many gastrointestinal diseases, including cancer screening and staging, intestinal bleeding, diarrhea, abdominal symptom evaluation, and inflammatory bowel disease assessment. However, the evaluation, classification, and quantification of findings from colonoscopy are subject to inter-observer variation. Automated assessment of colonoscopy is of interest considering the subjectivity present in qualitative human interpretations of colonoscopy findings. Localization of the camera is essential to interpreting the meaning and context of findings for diseases evaluated by colonoscopy. In this study, we propose a camera localization system to estimate the relative location of the camera and classify the colon into anatomical segments. The camera localization system begins with non-informative frame detection and removal. Then a self-training end-to-end convolutional neural network is built to estimate the camera motion, where several strategies are proposed to improve its robustness and generalization on endoscopic videos. Using the estimated camera motion a camera trajectory can be derived and a relative location index calculated. Based on the estimated location index, anatomical colon segment classification is performed by constructing a colon template. The proposed motion estimation algorithm was evaluated on an external dataset containing the ground truth for camera pose. The experimental results show that the performance of the proposed method is superior to other published methods. The relative location index estimation and anatomical region classification were further validated using colonoscopy videos collected from routine clinical practice. This validation yielded an average accuracy in classification of 0.754, which is substantially higher than the performances obtained using location indices built from other methods.
A systolic machine for string correction (1987)

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Initial Results of the MINDView PET Insert Inside the 3T mMR (2018)

Hybrid molecular and anatomical imaging devices, especially when simultaneously working, have shown to provide advantages over sequential acquisitions. In particular, we present in this preliminary study, the working performance of a brain positron emission tomography (PET) insert, within a 3T magnetic resonance imaging (MRI) system. To our knowledge, this is the largest PET system based on monolithic LYSO blocks. It consists of 60 scintillator blocks of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$50\ \text{mm} \times 50\ \text{mm} \times 20\ \text{mm}$ </tex-math></inline-formula> arranged in 3 rings of 20 detector modules each. An effective field of view (FOV) of 240 mm in diameter and 154 mm axially is defined. The crystals included a retroreflector layer at the entrance face, and are coupled to custom arrays of <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$12 \times 12$ </tex-math></inline-formula> silicon photomultipliers (SiPM), <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$3\ \text{mm} \times 3\ \text{mm}$ </tex-math></inline-formula> each. Frontend electronics provide <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${X}$ </tex-math></inline-formula> and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${Y}$ </tex-math></inline-formula> projections of the scintillation light by sampling each row and column of the SiPM arrays. The insert is thermally stabilized by using temperature-controlled air to about 27 °C. The PET insert has been installed at the Klinikum rechts der Isar (Munich) and tested within the whole-body Siemens biograph mMR, a 3T MRI combined with a PET scanner. A system sensitivity of almost 7% for an energy window of 350–650 keV was measured using a small size source at the center of the FOV (CFOV). Current system evaluation showed a spatial resolution at the CFOV of 1.7 mm using iterative algorithms, being below 2 mm within a centered diameter of 120 mm. Rods of a small Derenzo phantom of 2.5 mm were clearly resolved, independently of all tested MRI sequences including echo-planar imaging, ultrashort time echo, MPrage, and T2-flair or arterial spin labeling. The PET insert did not show any count rate degradation also under those sequences for a variety of MR imaging acquisitions.
Preparation, Electro-Optics, and Applications of Stressed Liquid Crystals (2017)

This paper is aimed at the development of the detailed procedure describing how to produce and characterize stressed liquid crystals, a class of promising electro-optical materials characterized by a giant phase modulation and fast response.
The Rainwater Memorial Calibration Facility for X-Ray Optics (2011)

The Nuclear Spectroscopic Telescope ARray (NuSTAR) is a NASA Small Explorer mission that will carry the first focusing hard X-ray (5–80 keV) telescope to orbit. The ground calibration of the optics posed a challenge as the need to suppress finite source distance effects over the full optic and the energy range of interest were unique requirements not met by any existing facility. In this paper we present the requirements for the NuSTAR optics ground calibration, and how the Rainwater Memorial Calibration Facility, RaMCaF, is designed to meet the calibration requirements. The nearly 175 m long beamline sports a 48 cm diameter 5–100 keV X-ray beam and is capable of carrying out detailed studies of large diameter optic elements, such as the NuSTAR optics, as well as flat multilayer-coated Silicon wafers.