gebhart/patrepeval huggingface dataset:
Tools for Diagnosing Migraine and Measuring Its Severity (2004)

Migraine remains substantially underdiagnosed and undertreated in the United States. Tools to screen for migraine and to measure headache-related disability can help address barriers to effective diagnosis and treatment. In this article, public health criteria for screening programs for any medical condition are first reviewed. Modifications of these criteria for migraine and other chronic/episodic disorders are then proposed. Migraine is assessed to determine how well it meets criteria for screening and the steps that are necessary before firm public policy recommendations for screening for migraine are possible.
Minimally Invasive Genioplasty Procedure (2017)

In this technical note, we present a new surgical approach for genioplasty in which a minimally invasive procedure is used to perform the chin osteotomy. The main goal was to reduce postoperative functional recovery time and possible complications, especially reduction of lip incompetence, chin ptosis, and muscle dysfunction, by retaining the intactness of the mentalis muscles.
Lockheed Martin Response to the OSP Challenge (2003)

The Lockheed Martin Orbital Space Plane System provides crew transfer and rescue for the International Space Station more safely and affordably than current human space transportation systems. Through planned upgrades and spiral development, it is also capable of satisfying the Nation's evolving space transportation requirements and enabling the national vision for human space flight. The OSP System, formulated through rigorous requirements definition and decomposition, consists of spacecraft and launch vehicle flight elements, ground processing facilities and existing transportation, launch complex, range, mission control, weather, navigation, communication and tracking infrastructure. The concept of operations, including procurement, mission planning, launch preparation, launch and mission operations and vehicle maintenance, repair and turnaround, is structured to maximize flexibility and mission availability and minimize program life cycle cost. The approach to human rating and crew safety utilizes simplicity, performance margin, redundancy, abort modes and escape modes to mitigate credible hazards that cannot be designed out of the system.
Mathematical Analysis of Glioma Growth in a Murine Model (2017)

Five immunocompetent C57BL/6-cBrd/cBrd/Cr (albino C57BL/6) mice were injected with GL261-luc2 cells, a cell line sharing characteristics of human glioblastoma multiforme (GBM). The mice were imaged using magnetic resonance (MR) at five separate time points to characterize growth and development of the tumor. After 25 days, the final tumor volumes of the mice varied from 12 mm<sup>3</sup> to 62 mm<sup>3</sup>, even though mice were inoculated from the same tumor cell line under carefully controlled conditions. We generated hypotheses to explore large variances in final tumor size and tested them with our simple reaction-diffusion model in both a 3-dimensional (3D) finite difference method and a 2-dimensional (2D) level set method. The parameters obtained from a best-fit procedure, designed to yield simulated tumors as close as possible to the observed ones, vary by an order of magnitude between the three mice analyzed in detail. These differences may reflect morphological and biological variability in tumor growth, as well as errors in the mathematical model, perhaps from an oversimplification of the tumor dynamics or nonidentifiability of parameters. Our results generate parameters that match other experimental in vitro and in vivo measurements. Additionally, we calculate wave speed, which matches with other rat and human measurements.
Modification of P4 position in beta-Secretase (BACE1) inhibitors containing phenylnorstatine (2006)

The authors have already designed and synthesized a potent and chem. stable pentapeptide type BACE1 inhibitor KMI-429 with IC50 = 3.9 nM contg. a hydroxymethylcarbonyl (HMC) isostere with phenylnorstatine [(2R,3S)-3-amino-2-hydroxy-4-phenylbutyric acid; Pns] at the P1 position. The focus of this work was on optimizing the structure of the N-terminal of the inhibitors. The SAR study at the P4 position was carried out to improve the activity and physicochem. property of the inhibitors.
Molecular Diagnostics in Non-Small Cell Lung Carcinoma (2020)

Current clinical practice guidelines recognize <i>EGFR, BRAF, ALK,</i> and <i>ROS1</i> as essential molecular biomarkers, and a host of other genetic alterations as emerging biomarkers for non-small cell lung carcinoma patients. The available approaches to detecting relevant alterations in these genes are diverse and often complementary. Laboratories have increasingly migrated away from a "single-gene test" approach, embracing assays that incorporate panels of genes capable of detecting a diverse set of alterations. The adoption of next generation sequencing (NGS) techniques has driven this shift; however, the approach to incorporation of NGS varies greatly between practices. Choice of molecular diagnostics assay, be it single-gene or NGS-based panel, will be driven by cost, urgency, clinical and laboratory focus, and professional considerations. Preanalytic factors including operator expertise, sample type and choice of fixative, and postanalytic factors including informatics pipeline and approaches to variant reporting have a significant impact on the quality of molecular diagnostics results. There is no real "one-size-fits-all" test for genomic profiling for lung cancer; clinicians and laboratorians must be prepared to offer a diverse set of assays in order to address turnaround time requirements and optimize detection of critical but difficult-to-detect tumor alterations such as gene fusions.
Utilization of Lignocellulosic Biomass via Novel Sustainable Process (2018)

In this review, we show novel methods for utilizing lignocellulosic biomass, polysaccharides, and lignin. Firstly, the simultaneous enzymatic saccharification and comminution (SESC) of plant materials is described as an extraction method for lignocellulosic biomass that does not require toxic reagents or organic solvents. Secondly, we demonstrate the material utilization of non-deteriorated lignocellulosic biomass extracted by SESC, such as for sugar and ethanol synthesis, and as a heatproof filler. Finally, we exhibit the use of a functional monomer (e.g., in disinfection chemicals, cesium chelation, and building blocks for polymers), 2-pyrone-4,6-dicarboxylic acid, derived from lignin via metabolic degradation.
A Novel Geographic Set-up and an Access Protocol for Mesh, Ad-Hoc and Cognitive Networks (2009)

This paper introduces a combined geographic and a Media Access Control (MAC) protocol for mesh, ad-hoc and cognitive networks. For mesh and ad-hoc networks, this paper examines the end-to-end (source to destination) link performance characteristics when supporting multimedia traffic. This paper also explains the cognitive network concept prior to analyzing cognitive network related results. The performance analysis was performed by a Monte Carlo simulator, the accuracy of which was verified by a Markov model analysis. An overlaid cell structure was considered for the Monte Carlo simulation where the terminals can be mobile within this environment. The system model includes Rice fading, log-normal shadowing and distance dependent pathloss. The system model also considers preferential channel access based on the capture effect. For mesh and ad-hoc networks, the proposed MAC protocol produced satisfactory performance characteristics in the presence of multimedia traffic. These results also show performance benefits of mesh networks over ad-hoc networks and how network density affects the network performance. Finally, the effect of primary users in cognitive networks is demonstrated.
The Naval Research Laboratory MEM adaptive optics program (2010)

The Naval Prototype Optical Interferometer (NPOI) is the longest baseline interferometer operating at visible wavelengths in the world. The astronomical capabilities of such an instrument are being exploited and recent results will be presented. NPOI is also the largest optical telescope belonging to the US Department of Defense with a maximum baseline of 435 meter has a resolution that is approximately 181 times the resolution attainable by the Hubble Space Telescope (HST) and 118 times the resolution attainable by the Advanced Electro-Optical System (AEOS). It is also the only optical interferometer capable of recombining up to six apertures simultaneously. The NPOI is a sparse aperture and its sensitivity is limited by the size of the unit aperture, currently that size is 0.5 meters. In order to increase the overall sensitivity of the instrument a program was started to manufacture larger, 1.4 meter, ultra-light telescopes. The lightness of the telescopes requirement is due to the fact that telescopes have to be easily transportable in order to reconfigure the array. For this reason a program was started three years ago to investigate the feasibility of manufacturing Carbon Fiber Reinforced Polymer (CFRP) telescopes, including the optics. Furthermore, since the unit apertures are now much larger than r0 there is a need to compensate the aperture with adaptive optics (AO). Since the need for mobility of the telescopes, compact AO systems, based on Micro-Electro-Mechanical-Systems (MEMS), have been developed. This paper will present the status of our adaptive optics system and some of the results attained so far with it.
Combination Therapy with Amprenavir, Abacavir, and Efavirenz in Human Immunodeficiency Virus (HIV)-Infected Patients Failing a Protease-Inhibitor Regimen: Pharmacokinetic Drug Interactions and Antiviral Activity (2000)

Patients with plasma viral RNA >50,000 copies/mL, despite a protease-inhibitor regimen, received abacavir, amprenavir, and efavirenz to assess efavirenz-amprenavir drug interactions and to evaluate safety and antiviral response. Patients first received amprenavir with abacavir and other nucleoside analogs. Amprenavir levels were measured before and after adding efavirenz. Patients then received a second protease inhibitor. There was evidence of genotypic and phenotypic resistance at study entry. No patient had study drugs discontinued because of toxicity. Efavirenz decreased the steady-state area under the curve, maximum plasma concentration, and minimum plasma concentration of amprenavir by 24%, 33%, and 43%, respectively. Three of 10 patients had >1.5 log10 viral response to abacavir and amprenavir. All 8 patients who added efavirenz had >0.5 log10 decline in viral load, and this response lasted >24 weeks for 3 of the patients. A combination regimen that included abacavir, amprenavir, and efavirenz was well tolerated and had sustained activity in some patients. Concomitant efavirenz therapy decreases amprenavir concentrations.
Common concerns, barriers to care, and the lived experience of individuals with hepatitis B: a qualitative study (2021)

People living with HBV are in need of information to manage their disease and prevent its spread. Analysis of queries uncovered significant misconceptions about HBV transmission and treatment. Additionally, the emotional and psychological impact of an HBV diagnosis on those living with the infection is significant. There is a clear need for patient and community education to expand knowledge and awareness of HBV globally to achieve 2030 WHO HBV elimination goals.
Design of a Pulsed Flux Concentrator for the ILC Positron Source (2010)

The positron source at a future TeV scale electron linear collider will need to generate positrons at a rate two orders of magnitude larger than have been previously achieved. We report on a design of a 3.5 Tesla pulsed flux concentrator magnet which uses liquid nitrogen cooling of the flux concentrator plates to reduce the electrical resistance leading to reduced energy deposition and the ability to generate the required 1 ms pulse duration. This magnet can double the collection efficiency of positrons emitted from the target.
Synthetic Oligonucleotide Libraries Reveal Novel Regulatory Elements in <i>Chlamydomonas</i> Chloroplast mRNAs (2012)

Gene expression in chloroplasts is highly regulated during translation by sequence and secondary-structure elements in the 5' untranslated region (UTR) of mRNAs. These chloroplast mRNA 5' UTRs interact with nuclear-encoded factors to regulate mRNA processing, stability, and translation initiation. Although several UTR elements in chloroplast mRNAs have been identified by site-directed mutagenesis, the complete set of elements required for expression of plastid mRNAs remains undefined. Here we present a synthetic biology approach using an arrayed oligonucleotide library to examine in vivo hundreds of designed variants of endogenous UTRs from Chlamydomonas reinhardtii and quantitatively identify essential regions through next-generation sequencing of thousands of mutants. We validate this strategy by characterizing the relatively well-studied 5' UTR of the psbD mRNA encoding the D2 protein in photosystem II and find that our analysis generally agrees with previous work identifying regions of importance but significantly expands and clarifies the boundaries of these regulatory regions. We then use this strategy to characterize the previously unstudied psaA 5' UTR and obtain a detailed map of regions essential for both positive and negative regulation. This analysis can be performed in a high-throughput manner relative to previous site-directed mutagenesis methods, enabling compilation of a large unbiased data set of regulatory elements of chloroplast gene expression. Finally, we create a novel synthetic UTR based on aggregate sequence analysis from the libraries and demonstrate that it significantly increases accumulation of an exogenous protein, attesting to the utility of this strategy for enhancing protein production in algal chloroplasts.
Optimizing concentrating solar collection systems considering integrated performance over time band and location (2007)

The optical design of a solar concentrator is based not on understanding and evaluating a point solution in time, but instead on the integrated performance over a band of time. Important additional factors are to evaluate different locations in the world and different seasons. Here we construct a software tool for modeling bands of time and use it to study different types of passive, low-concentration, CPC-profile solar collectors. Extruded trough geometry is shown to have superior performance to an annulus, and a cylindrically curved CPC profile had better pointing tolerance than the trough collector.
Role of Growth Factors in the Incorporation of Unloaded Bone Allografts in the Goat (1999)

Revision of a failed total joint replacement often demands bone grafting methods to restore deficient bone stock. However, impaired allograft incorporation can be the result of inadequate host or graft properties. The stimulation of bone healing with growth factors could provide a new approach to deal with this problem. The repeated sampling bone chamber was used in the goat to investigate the properties of bone allografts enriched with transforming growth factor-beta, recombinant human bone morphogenetic protein-2, and basic fibroblastic growth factor under unfavorable vascular and nonloaded conditions. Ten goats each had three bone chambers implanted in the medial proximal tibia. Different carrier allograft bone preparations were used for each growth factor based on convention and previously reported results. The period between implantation and chamber harvest was 8 weeks. The concentrations of the growth factors used was 0, 1, or 10 micrograms of transforming growth factor-beta 2, 0, 1, or 5 micrograms of bone morphogenetic protein-2, and 0, 40, 200 ng of basic fibroblastic growth factor. The specimens were analyzed histomorphometrically for the amount of soft tissue ingrowth, bone ingrowth, and the number of osteoclasts. In all specimens, a resorption front grew into the graft followed by fibrovascular tissue and, in some instances, bone. In the 5 micrograms of bone morphogenetic protein-2 specimens, larger amounts of soft tissue and woven bone were present, whereas in the specimens that received 10 micrograms of transforming growth factor-beta 2, there was a decrease in the amount of tissue and bone ingrowth. Two hundred nanograms of basic fibroblastic growth factor had a negative effect on soft tissue formation but increased the amount of vascular elements containing erythrocytes. The number of osteoclasts was higher in the 5-microgram bone recombinant human morphogenetic protein-2 specimens. In the clinical arena with absence of good perigraft vascularization and loading, bone morphogenetic protein-2 may have a strong stimulatory effect on bone graft incorporation.
Performance evaluation of emerging block copolymer membranes for oil-water separation (2022)

Abstract Membrane processes such as microfiltration (MF) and ultrafiltration (UF) are known to be the best advanced technologies for water reuse application. Numerous research efforts have been conducted in areas of modifying commercial MF/UF products or synthesizing novel materials promising enhanced oil-water separation performances. Block copolymer (BCP)-based membranes have recently gained increased popularity due to their improved water permeabilities. This study applies a comprehensive testing protocol for performance evaluation of two emerging poly (styrene-block-methyl methacrylate) BCP membranes developed by the project team. Tests mimicking industrial conditions were conducted by using a representative synthetic produced water and operating repeat tests. Both BCP membranes (referred to as A &amp; B) were found to possess high permeabilities of 5538 and 12,424 LMH/bar, respectively. Membrane B showed higher organic rejection at 79% against 74% rejection obtained for membrane A. The novel membranes were then compared to a relevant commercial product. Lower permeability at 3831 LMH/bar and slightly higher rejection performance (within ~ 10%) were obtained for the commercial membrane as compared to the BCP membranes. Test results obtained for those novel membranes being still in the development stage will be utilized in future studies investigating further optimization of the membrane structure and oil-water separation performance. Graphical Abstract
Nano-CMOS Design for Manufacturability: Robust Circuit and Physical Design for Sub-65nm Technology Nodes (2008)

This book is the sequel to Nano-CMOS Circuit and Physical Design, taking design to technology nodes beyond 65nm geometries. It examines the challenges that design engineers face in the nano-scaled era, such as exacerbated effects and the proven design for manufacturability (DFM) methodology in the midst of increasing variability and design process interactions. It also tackles complex issues in the design process and introduces several emerging concepts, including stress proximity effects, contour-based extraction, and design process interactions.
Chromogranin A Deficiency Confers Protection from Autoimmune Diabetes Via Multiple Mechanisms (2021)

Enteroviruses, including the Coxsackievirus Bs (CVB), have been implicated as causal agents in human type 1 diabetes. Immunization of at-risk individuals with a CVB vaccine provides an attractive strategy for elucidating the role of CVBs in the disease etiology. Previously we have shown that an inactivated whole-virus vaccine covering all CVB serotypes (CVB1-6) is safe to administer and highly immunogenic in preclinical models, including non-human primates. Before initiating clinical trials with this type of vaccine it was also important to address whether a) the vaccine itself induces adverse immune reactions including accelerating diabetes onset in a diabetes prone host and b) the vaccine can prevent CVB induced diabetes in a well-established disease model. Here we present results from studies in which female NOD mice were left untreated, mock-vaccinated or vaccinated with CVB1-6 vaccine and monitored for insulitis occurrence or diabetes development. We demonstrate that vaccination induces virus neutralizing antibodies without altering insulitis scores or the onset of diabetes. We also show that NOD mice vaccinated with a CVB1 vaccine are protected from CVB-induced accelerated disease onset. Taken together, these studies show that CVB vaccines do not alter islet inflammation or accelerate disease progression in an animal model that spontaneously develops autoimmune type 1 diabetes. However, they can prevent CVB-mediated disease progression in the same model. &lt;b&gt;&lt;/b&gt;
Biologic activities of poly (2-azaadenylic acid) and poly (2-azainosinic acid) (1977)

Poly (2-azaadenylic acid) [(aza2A)n] and poly(2-azainosinic acid [(aza2I)n], two newly synthesized analogues of (A)n and (I)n, in which CH-2 of the purine ring is replaced by a nitrogen atom, have been evaluated in various biological assay systems. (Aza2A) n formed a complex with (U)n and (br5U)n, and (aza2I)n formed a complex with (C)n and (br5C)n, but these complexes were markedly destabilized relative to the corresponding (A)n or (I)n complexes. The (aza2A)n-and (aza2I)n-derived complexes failed to stimulate the production of interferon in primary rabbit kidney cells and human diploid fibroblasts, under conditions (A)n. (U)n, (I)n. (C)n and (I)n. (br5C)n induced high amounts of interferon. both (aza2A)n and (aza2I)n exerted a marked inhibitory effect on the endogenous RNA directed DNA polymerase (reverse transcriptase) activity associated with murine leukemia virus. They caused a relatively mild inhibition of complement activity in an hemolytic assay system.
Nanotechnological Strategies for Administration of Poorly Soluble Neuroactive Drugs (2020)

Many neuroactive drugs are characterized by poor solubility, hampering their therapeutic potential and clinical research studies. For instance, the lipophilic molecules dimethylfumarate, retinyl palmitate, progesterone, and URB597 can be employed in the treatment of relapsing remitting multiple, early brain injury, learning deficits, and/or traumatic brain injuries. In this study, the possibility to encapsulate these drugs in lipid nanoparticles is investigated. Solid lipid nanoparticles and nanostructured lipid carriers have been produced by melt and ultrasonication of stearic triglyceride or a mixture of stearic triglyceride and caprylic/capric triglycerides. Mean diameters and morphology of lipid particles were studied by photon correlation spectroscopy, cryo-transmission electron microscopy, and x-ray diffraction, while encapsulation efficiency and in vitro drug release have been determined by HPLC. A behavioral study was conducted in rats to study the capability of lipid nanoparticles containing URB597 to alter behaviors relevant to psychiatric disorders after intranasal administration. In this regard, the nanoparticle surface has been modified by polysorbate 80 in order to obtain “stealth” nanoparticles. The nanoencapsulation strategy allowed increased drug solubility with respect to unphysiological solvent or solvent mixtures usually employed for animal and clinical studies. In particular, retinyl palmitate solubility in nanostructured lipid carriers has been increased up to eight-fold. Moreover, rat behavioral effects observed by nanoencapsulated URB597 administered intranasally suggest the therapeutic potential of this non-invasive route to treat social dysfunctions, such as autism.