gebhart/patrepeval huggingface dataset:
Perioperativna uporaba medicinske hipnoze (2021)

Perioperativni čustveni stres je za bolnika slaba izkušnja, ki ima negativne posledice. Zmanjšamo ga lahko s farmakološkimi ali nefarmakološkimi metodami. Medicinska hipnoza je nefarmakološka metoda, ki zmanjša perioperativni stres in bolečino. Hipnosedacija je anestezijska tehnika, pri kateri se medicinska hipnoza uporablja kot dodatek k lokalni ali področni anesteziji ob sedaciji ali analgeziji. Izboljša udobje med posegom, zmanjša občutek tesnobe, bolečine, porabo anksiolitikov in analgetikov, izboljša pogoje za operacijo in skrajša čas okrevanja. Uporablja se le pri določenih kirurških posegih in pri izbranih bolnikih. Multimodalna strategija zdravljenja vključuje tako farmakološke kot nefarmakološke pristope. Medicinska hipnoza se lahko uporablja kot sredstvo, ki učinkovito dopolnjuje perioperativno zdravljenje.
Hydrogels of Polycationic Acetohydrazone-Modified Phosphorus Dendrimers for Biomedical Applications: Gelation Studies and Nucleic Acid Loading (2018)

In this work, we report the assemblage of hydrogels from phosphorus dendrimers in the presence of biocompatible additives and the study of their interactions with nucleic acids. As precursors for hydrogels, phosphorus dendrimers of generations 1⁻3 based on the cyclotriphosphazene core and bearing ammonium or pyridinium acetohydrazones (Girard reagents) on the periphery have been synthesized. The gelation was done by the incubation of dendrimer solutions in water or phosphate-buffered saline in the presence of biocompatible additives (glucose, glycine or polyethylene glycol) to form physical gels. Physical properties of gels have been shown to depend on the gelation conditions. Transmission electron microscopy revealed structural units and well-developed network structures of the hydrogels. The hydrogels were shown to bind nucleic acids efficiently. In summary, hydrogels of phosphorus dendrimers represent a useful tool for biomedical applications.
Abstract 14306: Development of Sleep-Disordered Breathing Destabilizes Ventricular Repolarization (2022)

Introduction: Sleep-disordered breathing (SDB) is a prevalent condition associated with adverse cardiovascular events, including nocturnal arrhythmias and sudden cardiac death, but the underlying mechanism is unclear. Hypothesis: Ventricular repolarization instability increases in those who develop SDB. Methods: For the participants of the Sleep Heart Health Study (SHHS), the percentage of sleep time with oxygen saturation levels &lt; 90% (T90) was measured. We identified participants who did not have SDB (T90 &lt; 0.22% = median of the SHHS cohort) during the initial study but developed SDB (T90 &gt; 10%) by the time of the 5-year follow-up. A comparator group was identified as those who matched the first group on age, sex, BMI, and race but had T90 &lt; 0.22% during both the initial and the follow-up sleep studies. Each group consisted of 25 (8 M and 17 F) participants, none of whom had any diagnosed comorbidities or prescriptions that could affect cardiac repolarization. Heart rate (HR), heart rate variability (SDNN), and QT variability index (QTVI, a measure of ventricular repolarization instability) were calculated from one-lead ECG recordings. Paired sample t- test was used to assess statistical associations. Results: The respiratory disturbance index (RDI) for the study group increased from 2.57 ± 0.74 events/hr at baseline to 14.8 ± 3.72 events/hr at follow-up (P = 0.001), while the RDI was not different for the comparators (3.08 ± 0.71 events/hr at baseline, 3.65 ± 0.68 events/hr at follow-up, P = 0.599). In those who developed SDB, HR and SDNN did not change between baseline and follow-up, but QTVI increased from -1.25 ± 0.15 to -0.85 ± 0.15 (P = 0.013). None of the measured electrocardiographic parameters differed between baseline and follow-up in comparators. Conclusion: Over a five-year follow-up, the development of SDB was associated with an increase in QT variability comparable to symptomatic heart failure. Hypoxemia appears to be the main underlying mechanism.
Diarrea emorragica: a volte i nodi vengono al pettine tardi (2023)

The case of a two-year-old girl finally diagnosed with haemolytic uremic syndrome is described.
Treatment possibilities for patients with advanced prostate cancer (2006)

Prostate cancer is the second leading cause of cancer-related death in Switzerland as well as in other western countries. For patients with advanced disease, ablation of androgens is regarded as optimal first-line treatment. But this treatment is palliative with a median duration of response of about 18 months and hormone refractory prostate cancer remains a challenge. Last year, two large randomised trials demonstrated for the first time a survival benefit with docetaxel based therapy. Additionally, because of better understanding of the biology of hormone refractory prostate cancer a number of new systemic therapies are emerging. To evaluate their usefulness and to make progress in the therapy of this disease, it is essential to enrol prostate cancer patients in clinical trials. Another important issue are bone metastases because they are a significant cause of pain and morbidity in prostate cancer patients. Palliation of pain can be achieved with different means like radiation therapy, radioisotopes, hormonal therapy, chemotherapy, and bisphosphonates. For the optimal treatment of patients with symptomatic advanced prostate cancer a multidisciplinary approach is mandatory.
Multiple-wavelength free-space laser communications (2003)

Free-space optical communications systems in the atmosphere, based on intensity modulation and direct detection, are heavily affected by fading caused by turbulence cells of varying scale and motion. Several data sets of fading measurements under different scenarios have been recorded demonstrating this effect. In this paper we introduce a form of free-space laser communications involving a source operating on several wavelengths. The goal is to overcome atmospheric interference on a communications link. We have performed simulations using the DLR PILab Matlab toolbox. These indicate the extent to which the turbulence and beam properties interact. Experimental investigations are planned. Further properties are also taken into account, including the choice of appropriate laser bandwidth and wavelengths, the effect of atmospheric absorption from aerosols and molecular absorption lines, as well as effects of atmospheric structure on beam propagation. Possible scenarios for application of this scheme will be presented as well.
Platelet-derived growth factor-dependent association of the GTPase-activating protein of Ras and Src (1999)

Here we report that the platelet-derived growth factor β receptor (βPDGFR) is not the only tyrosine kinase able to associate with the GTPase-activating protein of Ras (RasGAP). The interaction of non-βPDGFR kinase(s) with RasGAP was dependent on stimulation with platelet-derived growth factor (PDGF) and seemed to require tyrosine phosphorylation of RasGAP. Because the tyrosine phosphorylation site of RasGAP is in a sequence context that is favoured by the Src homology 2 (‘SH2’) domain of Src family members, we tested the possibility that Src was the kinase that associated with RasGAP. Indeed, Src interacted with phosphorylated RasGAP fusion proteins; immunodepletion of Src markedly decreased the recovery of the RasGAP-associated kinase activity. Thus PDGF-dependent tyrosine phosphorylation of RasGAP results in the formation of a complex between RasGAP and Src. To begin to address the relevance of these observations, we focused on the consequences of the interaction of Src and RasGAP. We found that a receptor mutant that did not activate Src was unable to efficiently mediate the tyrosine phosphorylation of phospholipase Cγ (PLCγ). Taken together, these observations support the following hypothesis. When RasGAP is recruited to the βPDGFR, it is phosphorylated and associates with Src. Once bound to RasGAP, Src is no longer able to promote the phosphorylation of PLCγ. This hypothesis offers a mechanistic explanation for our previously published findings that the recruitment of RasGAP to the βPDGFR attenuates the tyrosine phosphorylation of PLCγ. Finally, these findings suggest a novel way in which RasGAP negatively regulates signal relay by the βPDGFR.
Biomimetic Oxidation Studies. 11. Alkane Functionalization in Aqueous Solution Utilizing in Situ Formed [Fe<sub>2</sub>O(η<sup>1</sup>-H<sub>2</sub>O)(η<sup>1</sup>-OAc)(TPA)<sub>2</sub>]<sup>3+</sup>, as an MMO Model Precatalyst, Embedded in Surface-Derivatized Silica and Contained in Micelles (1999)

The biomimetic, methane monooxygenase enzyme (MMO) precatalyst, [Fe(2)O(eta(1)-H(2)O)(eta(1)-OAc)(TPA)(2)](3+) (TPA = tris[(2-pyridyl)methyl]amine), 1, formed in situ at pH 4.2 from [Fe(2)O(&mgr;-OAc)(TPA)(2)](3+), 2, was embedded in an amorphous silicate surface modified by a combination of hydrophilic poly(ethylene oxide) and hydrophobic poly(propylene oxide). The resulting catalytic assembly was found to be a biomimetic model for the MMO active site within a hydrophobic macroenvironment, allowing alkane functionalization with tert-butyl hydroperoxide (TBHP)/O(2) in an aqueous reaction medium (pH 4.2). For example, cyclohexane was oxidized to a mixture of cyclohexanone, cyclohexanol, and cyclohexyl-tert-butyl peroxide, in a ratio of approximately 3:1:2. The balance between poly(ethylene oxide) and poly(propylene oxide), tethered on the silica surface, was crucial for maximizing the catalytic activity. The silica-based catalytic assembly showed reactivity somewhat higher in comparison to an aqueous micelle system utilizing the surfactant, cetyltrimethylammonium hydrogen sulfate at its critical micelle concentration, in which functionalization of cyclohexane with TBHP/O(2) in the presence of 1 was also studied at pH 4.2 and was found to provide similar products: cyclohexanol, cyclohexanone, and cyclohexyl-tert-butyl peroxide, in a ratio of approximately 2:3:1. Moreover, the mechanism for both the silica-based catalytic assembly and the aqueous micelle system was found to occur via the Haber-Weiss process, in which redox chemistry between 1 and TBHP provides both the t-BuO(*)() and t-BuOO(*)()( )()radicals. The t-BuO(*)()( )()radical initiates the C-H functionalization reaction to form the carbon radical, followed by O(2) trapping, to provide cyclohexyl hydroperoxide, which produces the cyclohexanol and cyclohexanone in the presence of 1, whereas the coupling product emanates from t-BuOO(*)() and cyclohexyl radicals. A discussion concerning both approaches for alkane functionalization in water will be presented.
Coherent optical computing for T-ray imaging (2010)

Single-point imagery of 2D objects is proposed by exploiting the extreme broadband nature of an ultrafast terahertz wave. In the proposed imagery, a collimated terahertz beam is illuminated on an object, and the scattered fields are measured through a hole at the Fourier plane in a conventional terahertz time-domain spectroscope. This arrangement allows conversion of radial spatial frequencies of the object to the temporal spectrum of the pulse. Hence, a 2D image can be readily obtained by rotating a hole around the optical axis. Experimental results confirm that a complicated object can be reliably imaged using only 30 waveform measurements.
Synthesis of dicarboxylate oligosaccharide multilayer terminal functionality upon poly(lysine) dendrimer scaffolding (2002)

Abstract A reactive three‐layered dendrimer containing carboxyl groups was synthesized by the coupling of dicarboxylic acid and a highly reactive, two‐layered glycopeptide dendrimer. Lactose, maltose, or maltotriose was reacted with the poly(lysine) dendrimer in its third and fourth generations by reductive amination and afforded two‐layered glycolysine dendrimers. The reaction was conducted in a borate buffer (pH 9.0). 1 H NMR, 13 C NMR, and matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry analyses were applied for the determination of the structures of the products. When an excess amount of the oligosaccharide and a long reaction time were used, the degree of substitution increased to 1.5–2.0 against an amino group. For the preparation of highly reactive, multilayered dendrimers for an antigen carrier, C6 hydroxy groups of the oligosaccharides were selectively esterified by adipic acid and suberic acid to give 6‐ O ‐adipoyl oligosaccharide–poly(lysine) dendrimers and 6‐ O ‐suberoyl oligosaccharide–poly(lysine) dendrimers. The reactivity of these multilayered dendrimers was examined by a model reaction with phenylalanine ethyl ester. The dendrimer showed high reactivity, providing phenylalanine ethyl ester–dicarboxylate oligosaccharide–poly(lysine) dendrimers with a considerably high proportion of phenylalanine residues. © 2002 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 40: 3622–3633, 2002
Undersulfated chondroitin sulfate does not increase in osteoarthritic cartilage. (2004)

The structure of chondroitin sulfate in degenerated bovine cartilage did not support the hypothesis that sulfate depletion is present in osteoarthritic joint.
Thickness Effects on the Martensite Transformations and Mechanical Properties of Nanocrystalline NiTi Wires (2022)

This paper studied the features of the martensitic transformations and mechanical properties of 40, 60, and 90 µm thick NiTi wires with nanocrystalline B2 structures. It was established that the wires were composites and consisted of a TiNi matrix and a TiO<sub>2</sub> + TiNi<sub>3</sub> surface layer. Structural methods showed that the wire matrix was formed by grains of up to 20 nm in size. The method of measuring the electrical resistivity during cooling and heating revealed a two-stage nature of the martensitic transformation. Cyclic loading-unloading demonstrated that all the samples exhibited superelasticity effects and completely restored their shape when unloaded from a 4-8% relative strain at room temperature. An increase in mechanical characteristics with respect to the wire thickness was experimentally established. This was due to the change in the composition of the TiNi matrix during drawing.
Beacon-Based Wireless TSN Association (2022)

Time-sensitive networking (TSN) is utilized in industrial environments to support reliable low-latency communications. Bringing TSN features to wireless networks is getting traction recently by achieving time synchronization and traffic scheduling over wireless links. Besides these basic features, impact-less and network transparent association of prospective clients is paramount for wireless TSN. This demo presents an impactless TSN association procedure, where beacons are used to provide time synchronization and scheduling to prospective clients, where association procedure is done in reserved time slots. The presented demo is designed, implemented, and tested on top of a wireless Software Defined Radio platform using the IEEE802.11 standard. By utilizing a dashboard, this demo will demonstrate real-time control over association as well as high accuracy synchronization on client frame transmissions even with challenging scheduling configuration of 128 μ S timeslots.
Self‐Powered Gas Sensors: 2D Transition Metal Dichalcogenide Heterostructures for p‐ and n‐Type Photovoltaic Self‐Powered Gas Sensor (Adv. Funct. Mater. 43/2020) (2020)

In article number 2003360, Woo-Hee Kim, Jusang Park, Hyungjun Kim, and co-workers demonstrate a photovoltaic self-powered gas sensor using a two-dimensional (2D) transition metal dichalcogenide (TMD) heterostructure for the first time. The p- (WSe2/WS2) and n-type (MoS2/WSe2) gas sensors exhibit highly sensitive, selective gas sensing properties to NO2 and NH3 gas without external bias due to their photovoltaic features. Further, this study contributes toward revealing the gas sensing mechanism in the 2D TMD heterostructure.
Nonlinear Instability Analysis for Partially Premixed Swirl Flames (2013)

Limit-cycle prediction of thermoacoustic instabilities for unstable practical gas turbine combustion systems is still a challenge for the gas turbine industry. The nonlinear stability analysis is especially demanding for highly turbulent swirling flames with significant equivalence ratio fluctuations. In the present study, a partially premixed swirl-stabilized flame at a Reynolds number of approximately 35,000 is investigated. An experimentally obtained flame describing function (FDF) is used for the determination of the thermoacoustic oscillation frequency and amplitude. Damping is obtained directly from measurements. The multi-microphone method is used to determine the amplitude dependent transfer function of the flame as well as the transfer function of the burner and the acoustic response of the boundary conditions. Solving the thermoacoustic modeling framework, with the measured transfer functions incorporated, yields frequency and amplitude of the self-excited limit cycle oscillation. The error between model and experimental results is thoroughly assessed. Measurements were made for various lengths of the combustion chamber exhaust gas tube to verify the results for different frequencies and amplitudes. Good agreement is found for the entire range of combustor lengths investigated. A sensitivity analysis of the linear flame transfer function to several operational parameters is provided allowing for an assessment of the limits of the nonlinear stability analysis approach. Furthermore, the effect of amplitude dependent damping is addressed.
Electrical Behavior of Cu Thin Fluorinated PECVD Oxide MIS Capacitors (2000)

This paper reports the results of extensive bias temperature annealing investigations made with metal‐insulator semiconductor (MIS) capacitors of copper and fluorinated plasma‐enhanced chemical vapor deposition (PECVD) oxide. Reduction of resistance‐capacitance delay is necessary to improve interconnect performance. While copper has been accepted as the new interconnect metal, several low dielectric constant materials are being considered as potential replacements for silicon oxide. Fluorinated silicon oxides deposited by the PECVD process have a moderately low dielectric constant (K = 3.0–3.7). The film structure and electrical behavior of fluorinated films was found to depend on the flow rate of the fluorine precursor . In several cases, both fluorinated and nonfluorinated oxides exhibit significant leakage currents. The reason for such poor electrical behaior has been related to the presence of pinholelike defects (which were identified by KOH etch testing) in these oxides. The existence of such pinholes is believed to be associated with nucleation and growth processes during the deposition and the thickness of the deposited dielectric (100 nm) used in this investigation. © 2000 The Electrochemical Society. All rights reserved.
Fiber optic sensor system for remote, long-term monitoring of soil and groundwater contamination (1994)

We have developed a fiber-optic chemical sensor technology for the remote monitoring of various volatile solvents. The accuracy, linearity, and sensitivity of the sensor (<5 ppb by weight in water, determined by comparison with standard gas chromatographic measurements) are sufficient for environmental monitoring of at least trichloroethlyene (TCE) and chloroform.
Reaction Mechanism of Alanine Racemase from Bacillus stearothermophilus (2002)

The crystal structures of alanine racemase bound with reaction intermediate analogs, N-(5'-phosphopyridoxyl)-L-alanine (PLP-L-Ala) and N-(5'-phosphopyridoxyl)-D-alanine (PLP-D-Ala), were determined at 2.0-A resolution with the crystallographic R factor of 17.2 for PLP-L-Ala and 16.9 for PLP-D-Ala complexes. They were quite similar not only to each other but also to the structure of the native pyridoxal 5'-phosphate (PLP)-form enzyme; root mean square deviations at Calpha among the three structures were less than 0.28 A. The side chains of the amino acid residues around the PLP-L-Ala and PLP-D-Ala were virtually superimposable on each other as well as on those around PLP of the native holoenzyme. The alpha-hydrogen of the alanine moiety of PLP-L-Ala was located near the OH of Tyr(265)', whereas that of PLP-D-Ala was near the NZ of Lys(39). These support the previous findings that Tyr(265)' and Lys(39) are the catalytic bases removing alpha-hydrogen from L- and D-alanine, respectively. The prerequisite for this two-base mechanism is that the alpha-proton abstracted from the substrate is transferred (directly or indirectly) between the NZ of Lys(39) and the OH of Tyr(265'); otherwise the enzyme reaction stops after a single turnover. Only the carboxylate oxygen atom of either PLP-Ala enantiomer occurred at a reasonable position that can mediate the proton transfer; neither the amino acid side chains nor the water molecules were located in the vicinity. Therefore, we propose a mechanism of alanine racemase reaction in which the substrate carboxyl group directly participates in the catalysis by mediating the proton transfer between the two catalytic bases, Lys(39) and Tyr(265)'. The results of molecular orbital calculation also support this mechanism.
Electromagnetic Modeling of Third-Order Nonlinearities in Photonic Crystal Fibers Using a Vector Two-Dimensional FDTD Algorithm (2015)

An algorithm accounting for dispersive and third-order nonlinear effects in a vector two-dimensional FDTD method is developed and validated in this paper. Kerr and Raman phenomena are implemented in FDTD using a new approach, which combines the accuracy of a rigorous FDTD update scheme and the speed of an approximate solution. As it is shown in this paper, the proposed method is applicable to the mode analysis of waveguide structures, like photonic crystal fibers, where the appropriate balance between dispersion and nonlinear phenomena is essential for supercontinuum generation. Several computational examples discussed in this paper successfully validate the proposed method.
Quality inspection and optimization of concrete production by means of cusum techniques (2008)

In order to control the production of concrete, control charts can be used to detect significant changes in performance and to indicate when actions should be taken in order to meet the specifications. A cumulative sum control chart (CUSUM) is well adapted to detect the inherent and abrupt changes in the concrete production. In order to indicate when actions should be taken, a mask is superimposed on the CUSUM chart. In this paper, an original probabilistic background for the design of a one-sided U-mask is derived in relation to the quality inspection of concrete production. Operating characteristic curves (OC-curves) are calculated, using Monte Carlo simulation techniques. The parameter selection for the U-masks is based on the AOQL principle, which enables an objective parameter selection. Finally, the possibilities of the designed U-masks are illustrated with a case study, based on data from a Belgian concrete plant. Using the results of this paper it is possible to use the conformity assessment as a steering element for the production process of concrete.
Can Religiosity and Social Support Explain Effects of Trait Emotional Intelligence on Health-Related Quality of Life: A Cross-Cultural Study (2021)

Religion and social support along with trait emotional intelligence (EI) help individuals to reduce stress caused by difficult situations. Their implications may vary across cultures in reference to predicting health-related quality of life (HRQoL). A convenience sample of N = 200 chronic heart failure (CHF) patients was recruited at cardiology centers in Germany (n = 100) and Pakistan (n = 100). Results indicated that trait-EI predicted better mental component of HRQoL in Pakistani and German CHF patients. Friends as social support appeared relevant for German patients only. Qualitative data indicate an internal locus of control in German as compared to Pakistani patients. Strengthening the beneficial role of social support in Pakistani patients is one example of how the current findings may inspire culture-specific treatment to empower patients dealing with the detrimental effects of CHF.