gebhart/patrepeval huggingface dataset:
Two-Step Codeword Design for Millimeter Wave Massive MIMO Systems With Quantized Phase Shifters (2019)

In this paper, a two-step codeword design approach for millimeter wave (mmWave) massive MIMO systems is presented. Ideal codewords are first designed, which ignores the hardware constraints in terms of phase shifter resolution and the number of RF chains. Based on the ideal codewords, practical codewords are then obtained taking the hardware constraints into consideration. For the ideal codeword design in the first step, additional phase is introduced to the beam gain to provide extra degree of freedom. We develop a phase-shifted ideal codeword design (PS-ICD) method, which is based on alternative minimization with each iteration having a closed-form solution and can be extended to design more general beamforming vectors with different beam patterns. Once the ideal codewords are obtained in the first step, the practical codeword design problem in the second step is to approach the ideal codewords by considering the hardware constraints of the hybrid precoding structure in terms of phase shifter resolution and the number of RF chains. We propose a fast search based alternative minimization (FS-AltMin) algorithm that alternatively designs the analog precoder and digital precoder. Simulation results verify the effectiveness of the proposed methods and show that the codewords designed based on the two-step approach outperform those designed by the existing approaches.
Modeling of the all-gas-phase iodine laser (AGIL) (2005)

This work revisits the finite-rate chemistry mechanism for AGIL in light of recent rate measurements for kinetic processes. The effect of temperature dependence of kinetic processes measured only at room temperature conditions is explored by assuming a square-root dependence upon temperature in line with kinetic theory. A sensitivity study is performed to elucidate the relative impact of each chemical kinetic process modeled with respect to the larger set of modeled chemical kinetic processes. And reactant mixing is examined, with documentation of the effects of the reactant mixing predictions upon recent multi-watt power extraction experiments.
Midterm Outcome of the Edge-to-Edge Mitral Valve Repair in Mitral Regurgitation (2018)

Objective: The edge-to-edge mitral valve repair, invented by Alfieri and colleagues, introduced valve repair as a treatment option for patients with complex diseases where standard annuloplasty and related repair techniques are insufficient, due to annular calcification and patient frailty. We retrospectively evaluated the results of a transaortic edge-to-edge mitral valve repair (Alfieri stitch) in patients who were undergoing aortic valve replacement.
Composition of the cell wall polysaccharide produced by the unicellular red alga rhodella reticulata (1992)

The composition and heterogeneity of the cell-wall polysaccharide of the red alga Rhodella reticulata was studied by means of multi-step hydrolysis and charge fractionation. The polysaccharide was found to contain xylose, 3-O- methyl pentose, glucose, galactose, rhamnose, ribose, arabinose, 4-O-methylgalactose, mannose and glucuronic acid in the approximate proportions of 12.4:6.7:1:2.2:4:0.06:0.4:2.4:0.4:1.6, and traces of 2,4-dimethyl hexose. These results differ from those obtained from a single strong acidic hydrolysis performed in a previous study, mainly in the glucuronic acid and the two methylated sugars
Induction of Ammonium Metabolizing Enzymes is Related with Fruit Shelf Life in Tomato Crosses among Cultivated, Mutant and Exotic Germplasms (2007)

In a previous report, glutamine synthetase (GS) and glutamate dehydrogenase (GDH) were found to be differentially induced in fruits at two ripening stages among tomato lines with different shelf life (SL). The objective of the present research was to analyze SL and the induction of GS and GDH in the pericarp tissue at the mature-green and the red ripe stages in different tomato genotypes, including a set of hybrids and their parents. The L. esculentum parents were the standard ripening cultivar ‘Caimanta’, which produces round freshmarketable fruits, and two inbred lines, N and R, which are recessive for the nor and rin mutations, respectively. The exotic parent ‘Ceras’ belonged to the wild L. esculentum var. cerasiforme. Four crosses were assayed: F1 (‘Caimanta’ x N), F1 (‘Caimanta’ x ‘Ceras’), F1 (N x ‘Ceras’), and F1 (N x R). The concomitant presence of GS and GDH was found in the pericarp of mature-green and red ripe tomato fruits from N, R, ‘Ceras’, F1 (‘Caimanta’ x ‘Ceras’), F1 (N x ‘Ceras’), and F1 (N x R). All these genotypes had a long SL. Particularly, in red ripe fruits of N and R, the genotypes with the longest SL, two isoforms of GDH were detected. The F1 (‘Caimanta’ x N) had a quite shorter SL and presented a differential induction pattern: while GS was found just in mature-green fruits, GDH was present at both ripening stages. In ‘Caimanta’, the genotype with shortest SL, GS was present only at the mature-green stage and GDH at the red ripe stage.
Insights into Newer Antimicrobial Agents against Gram-negative Bacteria (2016)

Currently, drug resistance, especially against cephalosporins and carbapenems, among gram-negative bacteria is an important challenge, which is further enhanced by the limited availability of drugs against these bugs. There are certain antibiotics (colistin, fosfomycin, temocillin, and rifampicin) that have been revived from the past to tackle the menace of superbugs, including members of Enterobacteriaceae, Acinetobacter species, and Pseudomonas species. Very few newer antibiotics have been added to the pool of existing drugs. There are still many antibiotics that are passing through various phases of clinical trials. The initiative of Infectious Disease Society of America to develop 10 novel antibiotics against gram-negative bacilli by 2020 is a step to fill the gap of limited availability of drugs. This review aims to provide insights into the current and newer drugs in pipeline for the treatment of gram-negative bacteria and also discusses the major challenging issues for their management.
Fast Evaluation of the Radiation Patterns of True Time Delay Arrays With Beam Steering (2007)

A multilevel algorithm for the computation of the transient radiation patterns of true time delay (TTD) conformal arrays over a range of observation and beam steering directions is presented. The multilevel algorithm is based on hierarchical decomposition of the array into smaller sub-arrays of elements. At the finest level of decomposition, the angular-temporal radiation patterns of single-element sub-arrays are obtained over a sparse angular grid of directions and short temporal duration, by either measurement or calculation. Subsequent steps of the algorithm comprise multilevel aggregation of delayed sub-array contributions. This process continues until the transient radiation pattern of the whole array is obtained. At each level, the radiation pattern is interpolated to a finer angular grid of observations and steering directions followed by temporal delay compensation. The multilevel array decomposition algorithm attains a computational complexity substantially lower than that of the direct evaluation. Furthermore, the algorithm is particularly efficient for large arrays with large numbers of elements.
Is benign rolandic epilepsy genetically determined (2004)

Benign rolandic epilepsy (BRE) is considered to be a genetically determined idiopathic partial epilepsy. We studied twins with BRE and compared the concordance with a twin sample of idiopathic generalized epilepsy (IGE). All eight BRE pairs (six monozygous [MZ], two dizygous [DZ]) were discordant. MZ pairwise concordance was 0 (95% confidence interval [CI], 0–0.4) for BRE compared with 0.7 (95% CI, 0.5– 0.9) for 26 IGE MZ pairs. Our data suggest that conventional genetic influences in BRE are considerably less than for IGE, and other mechanisms need to be explored.
Targeting CCR5 trafficking to inhibit HIV-1 infection (2019)

Using a cell-based assay monitoring differential protein transport in the secretory pathway coupled to high-content screening, we have identified three molecules that specifically reduce the delivery of the major co-receptor for HIV-1, CCR5, to the plasma membrane. They have no effect on the closely related receptors CCR1 and CXCR4. These molecules are also potent in primary macrophages as they markedly decrease HIV entry. At the molecular level, two of these molecules inhibit the critical palmitoylation of CCR5 and thereby block CCR5 in the early secretory pathway. Our results open a clear therapeutics avenue based on trafficking control and demonstrate that preventing HIV infection can be performed at the level of its receptor delivery.
Determination of radiation by spherical wave expansionusing single dual-polarised field probe (1999)

A new matrix formulation for determining the field of a radio-frequency source is presented. The new matrix formulation gives a theoretical validation of measurements using a single dual-polarised field probe. It is shown that if the field magnitudes at two orthogonal tangential polarisations and the phase difference between the field components are measured at a number of locations, the radiated field may be determined without knowing the phase difference between the measurement locations.
Preparation of colored iron particles by multistratification with alternate thin layers of SiO2 and TiO2 (1999)

Coloring ferromagnetic fine particles was achieved only by coating the particles with SiO2 and TiO2 alternate layers of appropriate thickness that act as light interference filters. We propose a new model called the “hemisphere model” for the calculation of the optimum thickness of layers on spherical particles to obtain any specific colored particles. The stratification of alternative thin layers of SiO2 and TiO2 layers was achieved by deposition of amorphous SiO2 and quasigranular TiO2 layers by the sol-gel method.
Suppl Fig 1 from Targeting the Inducible T-cell Costimulator (ICOS) in Patients with Relapsed/Refractory T-follicular Helper Phenotype Peripheral T-cell and Angioimmunoblastic T-cell Lymphoma (2023)

&lt;p&gt;Supplemental Figure 1. CD4 count recovery after end of treatment (by local site collection)&lt;/p&gt;
Computationally efficient modeling of wafer temperatures in a low-pressure chemical vapor deposition furnace (2003)

A new thermal model is developed to predict wafer temperatures within a hot-wall low pressure chemical vapor deposition furnace based on the furnace wall temperatures as measured by thermocouples. Based on an energy balance of the furnace system, this model is a transformed linear model which captures the nonlinear relationship between the furnace wall temperature distribution and the wafer temperature distribution. The model can be solved with a direct algorithm instead of iterative algorithms which are used in all existing thermal models. Since the direct algorithm is noniterative, there is no convergence problem, nor local minima problem, related to nonlinear optimization. In addition, the direct algorithm greatly reduces the computation effort. Configuration factors are calculated by a finite area to finite area method. This avoids numerical integration methods which are much more difficult to implement and require more computation. The simplicity of the model form and the fast algorithm make the model useful for real-time updating and control. Model predictions show excellent agreement with experimental data.
A Discrete Model to Consider the Influence of the Air Flow on Blade Vibrations of an Integral Blisk Compressor Rotor (2008)

The influence of the aerodynamic coupling in the forced response analysis of a HPC test-blisk is studied by means of a reduced order mechanical model. In the first step this equivalent blisk model (EBM) is derived based on a finite element analysis of the disk from design and an adjustment to experimentally determined blade alone frequencies in order to consider the real blade mistuning. Applying the EBM — so far not considering the air flow influence — to carry out forced response analyses due to a rotating excitation acting on the stationary blisk, a maximum blade displacement amplification of more than 50% has been calculated comparing the tuned and the mistuned blisk. Aiming at an additional consideration of the air flow, fully coupled computations of the fluid structure interaction (FSI) are exemplarily carried out for elastically supported blades in a cascade arrangement. The results are used to calibrate simple mass-spring-damper models from which quantities of additional aerodynamic elements in terms of a consideration of co-vibrating air masses, air stiffening and aerodynamic damping are derived. Based on this information the EBM is extended to a so called advanced EBM. Aerodynamic influences are considered assigning the aerodynamic properties to each blade in dependence on the inter blade phase angle (IBPA). Forced response analyses, now including all aerodynamic influences, show that for an extreme application of a rear blisk close to the combustion chamber and under MTO conditions a strong smoothing of originally localized vibration modes occurs. The maximum blade displacement amplification due to mistuning is decreased from more than 50% to below 12% for the first blade flap mode.
Organometallic growth and characterization of Ga<i>x</i>In1−<i>x</i>P (<i>x</i>=0.51, 0.65, 0.69) (1986)

The growth and characterization of GaxIn1−xP (x=0.51, 0.65, 0.69) are described in this paper. The organometallic vapor-phase epitaxial (OMVPE) growth was carried out in an atomospheric pressure reactor using trimethylgallium (TMGa), trimethylindium (TMIn), and phosphine (PH3). GaAs and commercially available hydride vapor-phase epitaxial GaAs0.70P0.30 and GaAs0.61P0.39 were used as the substrates. The influence of growth temperature and V/III ratio on the properties of the OMVPE epilayers was studied. This resulted in the determination of an optimum growth temperature of 625 °C and an optimum V/III ratio range of 40–50. The results of the mismatch due to the different lattice constants of the GaxIn1−xP epilayer and the substrate were investigated. It was found that high-quality GaxIn1−xP epilayers can be obtained only when the mismatch ‖Δa/a0‖ is less than 1×10−3. Under the conditions mentioned above, epilayers were reproducibly obtained with featureless surface morphologies, and photoluminescence (PL) with high intensities and narrow half-widths (41–43 meV at 300 K). The dislocation etch pit densities ρ of Ga0.65In0.35P and Ga0.69In0.31P epilayers were 7.4–8.6×104 cm−2, grown lattice matched to GaAs1−yPy ( y=0.30, 0.39) substrates with ρ=6.4–7.5×105 cm−2. The degradation of PL intensity after annealing at temperatures between 400 and 600 °C in H2 or N2 indicates an increase in the surface recombination velocity for GaInP epilayers. Etching 30 Å from the surface was found to restore the original PL intensity.
HDA9-PWR-HOS15 Is a Core Histone Deacetylase Complex Regulating Transcription and Development (2019)

Histone deacetylases remove acetyl groups from histone proteins and play important roles in many genomic processes. How histone deacetylases perform specialized molecular and biological functions in plants is poorly understood. Here, we identify HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 15 (HOS15) as a core member of the Arabidopsis (<i>Arabidopsis thaliana</i>) HISTONE DEACETYLASE9-POWERDRESS (HDA9-PWR) complex. HOS15 immunoprecipitates with both HDA9 and PWR. Mutation of <i>HOS15</i> induces histone hyperacetylation and methylation changes similar to <i>hda9</i> and <i>pwr</i> mutants. <i>HOS15</i>, <i>HDA9</i>, and <i>PWR</i> are coexpressed in all organs, and mutant combinations display remarkable phenotypic resemblance and nonadditivity for organogenesis and developmental phase transitions. Ninety percent of <i>HOS15</i>-regulated genes are also controlled by <i>HDA9</i> and <i>PWR</i> HDA9 binds to and directly represses 92 genes, many of which are responsive to biotic and abiotic stimuli, including a family of ethylene response factor genes. Additionally, <i>HOS15</i> regulates HDA9 nuclear accumulation and chromatin association. Collectively, this study establishes that HOS15 forms a core complex with HDA9 and PWR to control gene expression and plant development.
Absolute bioavailability of evacetrapib in healthy subjects determined by simultaneous administration of oral evacetrapib and intravenous [<sup>13</sup>C<sub>8</sub>]‐evacetrapib as a tracer (2015)

This open-label, single-period study in healthy subjects estimated evacetrapib absolute bioavailability following simultaneous administration of a 130-mg evacetrapib oral dose and 4-h intravenous (IV) infusion of 175 µg [(13) C8 ]-evacetrapib as a tracer. Plasma samples collected through 168 h were analyzed for evacetrapib and [(13) C8 ]-evacetrapib using high-performance liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameter estimates following oral and IV doses, including area under the concentration-time curve (AUC) from zero to infinity (AUC[0-∞]) and to the last measureable concentration (AUC[0-tlast ]), were calculated. Bioavailability was calculated as the ratio of least-squares geometric mean of dose-normalized AUC (oral : IV) and corresponding 90% confidence interval (CI). Bioavailability of evacetrapib was 44.8% (90% CI: 42.2-47.6%) for AUC(0-∞) and 44.3% (90% CI: 41.8-46.9%) for AUC(0-tlast ). Evacetrapib was well tolerated with no reports of clinically significant safety assessment findings. This is among the first studies to estimate absolute bioavailability using simultaneous administration of an unlabeled oral dose with a (13) C-labeled IV microdose tracer at about 1/1000(th) the oral dose, with measurement in the pg/mL range. This approach is beneficial for poorly soluble drugs, does not require additional toxicology studies, does not change oral dose pharmacokinetics, and ultimately gives researchers another tool to evaluate absolute bioavailability.
A novel anti-inflammatory drug, SDZ ASM 981, for the topical and oral treatment of skin diseases:<i>in vivo</i>pharmacology (1997)

There is a need for safe and effective therapies for inflammatory skin diseases. Current topical and systemic treatment of psoriasis is effective but suffers from side-effects or is inconvenient. The therapeutic armamentarium for atopic dermatitis is very limited and far from satisfactory. In vivo preclinical data are presented for SDZ ASM 981, a novel ascomycin macrolactam derivative with high anti-inflammatory activity. Anti-inflammatory activity was observed in mouse, rat and pig models of allergic contact dermatitis. In the pig model, topical SDZ ASM 981 was as effective as the ultrapotent corticosteroid clobetasol-17-propionate, and when compared with a series of commercial topical corticosteroid preparations, 0.1% SDZ ASM 981 had equivalent efficacy to clobetasol-17-propionate (0.05%), the most potent product on the market. Unlike the corticosteroid, however, SDZ ASM 981 did not cause skin atrophy in pigs. SDZ ASM 981 potently inhibited allergic contact dermatitis in mice and rats when given systemically, and oral treatment was more effective than cyclosporin A in rats. Furthermore, SDZ ASM 981 has a low potential for affecting systemic immune responses, as demonstrated in rat models of localized graft vs. host reaction and allogeneic kidney transplantation. Preclinical results suggest that SDZ ASM 981 has the potential to be a well-tolerated and effective drug for topical as well as oral treatment of inflammatory skin diseases.
Analysis Of The Energy Dependence Of The Photorefractive Gain In Nanosecond Wave Mixing In Semiconductor Crystals. (1989)

Based on the results of two wave-mixing experiments in the nanosecond regime conducted in the semi-insulating crystal InP:Fe we present an analysis of the build-up of the photoinduced space charge field that governs the photorefractive effect. A numerical integration of the material&apos;s differential equations is carried out taking into account charge transport by holes and electrons. Competition between drift and diffusion, and between hole and electron charge transport limits the coupling gain. The time evolution and the role of the important quantities are explained by the use of appropriate approximations.
T cells, B cells, and PD-L1 expression in esophageal and gastric adenocarcinoma before and after neoadjuvant chemotherapy: relationship with histopathological response and survival (2021)

Perioperative chemotherapy enhances the survival rates for patients with esophageal and gastric (EG) adenocarcinoma, but not all patients benefit from this additional treatment. Chemotherapeutic agents have been demonstrated to alter the immune cell (IC) composition in the tumor microenvironment. Hence, there is a rationale to investigate the influence of neoadjuvant chemotherapy (NAC) on different IC subsets, to better understand and compare their utility as complementary prognostic or predictive biomarkers in a clinically relevant context. The density of T cells (CD8<sup>+</sup> and FoxP3<sup>+</sup>), B cells (CD20<sup>+</sup>) and the expression of PD-L1 on ICs and tumor cells (TC) was assessed by immunohistochemistry on paired biopsies from primary tumors (PT) pre-NAC, and resected PT and lymph node metastases post-NAC. The cohort encompasses 148 patients with resectable EG adenocarcinoma, all of whom received NAC. The density of CD8<sup>+</sup> cells was decreased and the density of FoxP3<sup>+</sup> cells and CD20<sup>+</sup> cells was increased in PT post-NAC. PD-L1 expression was not altered following NAC. In pre-NAC specimens, high FoxP3<sup>+</sup> density and high PD-L1 expression on ICs were favorable prognostic factors, whereas high CD8<sup>+</sup> density was an unfavorable prognostic factor. In post-NAC specimens, however, high FoxP3<sup>+</sup> density was an unfavorable prognostic factor, and high PD-L1 expression on TC was associated with a shorter survival. There were no significant associations between IC density or PD-L1 expression in PT pre-NAC and histopathological regression. These findings propose that NAC might alter the density and prognostic impact of some IC subsets in EG adenocarcinoma.