gebhart/patrepeval huggingface dataset:
Validation of the rAHF-PFM PK Guided Dose Calculator Medical Device Using an Unrelated Clinical Dataset (2014)

Abstract Introduction: Prevention of bleeding represents the standard of care for patients with hemophilia without inhibitors. However, standard prophylactic dosing regimens with FVIII are currently based on body weight alone and do not take into account considerable inter-individual variability in FVIII PK profiles. In order to facilitate personalization of prophylaxis to individual needs and individual PK response we have developed a device that allows PK guided dosing in routine clinical care. In fact, the major barrier of PK-guided dosing in clinical practice is the necessity of multiple blood samples (6 to 11 over 48 hours) associated with a single infusion and the lack of easy-to-use statistical software to generate classical PK profiles. Leveraging the vast rAHF-PFM clinical database with more than 150 classical PK assessments, a Population PK model for children and adults was combined with a Bayesian algorithm to create a user friendly medical device. This methodology allows the use of only a few samples after different infusions to estimate individual PK parameters and help to calculate dosing regimens. Methods: In order to carry on an external validation of the Bayesian population PK model of the device, individual 10 point PK assessment data from an unrelated source, i.e. not included in the base population PK model, (rAHF-PFM prophylaxis study, Valentino et al 2012) was utilized to validate the accuracy of the calculation. First, we compared predicted post infusion FVIII levels with observed FVIII levels using all the available post infusion samples. In a second step we compared individually estimated PK parameters as obtained by using 10 post infusion samples with a progressively reduced number of post infusion samples. Results: The external validation study indicated a good agreement between the observed and predicted FVIII levels (Figure) and PK parameters. Furthermore it showed that the rAHF-PFM medical device had a good predictive performance even when using only 2 sampling time-points. Figure 1 Figure 1. Conclusion: An easy-to-use medical device that can estimate PK parameters and thus assists in designing prophylactic dosing regimens based on individual- PK characteristics represents a groundbreaking innovation. This literally shifts the treatment paradigm from one-size-fits-all prophylaxis towards a more personalized therapy in hemophilia A and allows further optimization of dosing in patients in order to improve outcome in a sustainable fashion. Disclosures Steinitz: Baxter: Employment. Spotts:Baxter Healthcare Corporation: Employment. Loew-Baselli:Baxter Innovations GmbH: Employment, Equity Ownership. Oh:Baxter Healthcare Corporation: Employment. Penny:Baxter Healthcare Limited: Employment, Equity Ownership. Gringeri:Baxter Innovations GmbH: Employment. Reininger:Baxter Innovations GmBH: Employment, Equity Ownership.
Laparoscopically assisted myomectomy: a report of a new technique in 57 cases. (1994)

We found laparoscopically assisted myomectomy to be a safe alternative to myomectomy by laparotomy. It is technically less difficult than laparoscopic myomectomy, allows better closure of the uterine defect, and may require less time to perform.
Nanophase-Separated Supramolecular Assemblies of Two Functionalized Polymers via Acid–Base Complexation (2011)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTNanophase-Separated Supramolecular Assemblies of Two Functionalized Polymers via Acid–Base ComplexationAtsushi Noro*, Koji Ishihara, and Yushu Matsushita*View Author Information Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, JapanE-mail: [email protected] (Y.M.); [email protected] (A.N.).Cite this: Macromolecules 2011, 44, 16, 6241–6244Publication Date (Web):August 1, 2011Publication History Received24 June 2011Revised15 July 2011Published online1 August 2011Published inissue 23 August 2011https://pubs.acs.org/doi/10.1021/ma201440vhttps://doi.org/10.1021/ma201440vrapid-communicationACS PublicationsCopyright © 2011 American Chemical SocietyRequest reuse permissionsArticle Views2165Altmetric-Citations45LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Complexation,Organic acids,Polyethylenimine,Polymers,Supramolecular structures and assemblies Get e-Alerts
HeartMath approach to self-regulation and psychosocial well-being (2020)

The ability to alter one’s emotional responses is central to overall well-being and effectively meeting the demands of life. In this article, we discuss the perspective that one’s ability to self-regulate the quality of feeling and emotion of one’s moment-to-moment experience influences our physiology and the reciprocal interactions between physiological, cognitive, and emotional systems. We outline the bi-directional communication pathways between the heart and brain, and how neural activity in these pathways affect the central processes of cognitive and emotional function and self-regulatory capacity. We discuss how self-induced positive emotions is reflected in the pattern of one’s heart’s rhythm, which in turn increases the coherence in bodily processes. This shift in the heart rhythm plays an important role in facilitating higher cognitive functions, creating emotional flexibility, and facilitating social connectedness. Over time, this establishes a new inner-baseline reference, resulting in improvements in attention, behaviour, and measures of health and wellness.
Crystallization of purified recombinant human interleukin‐1β (1988)

The gene for human interleukin-1 beta was cloned from SK-hep-1 hepatoma cellular RNA and expressed at high levels in Escherichia coli both as the naturally processed form (rIL-1 beta) and as a variant with an additional sequence of three amino acids on the N-terminus (rIL-1 beta +). Expressed protein was purified to homogeneity by a sequence of steps, which included low pH incubation, adsorption and desorption from Procion Red Sepharose, sizing on a Superose 12 fast-performance liquid chromatography (FPLC) column, and anion exchange chromatography on QAE Sepharose. The final step provided a biologically active protein that migrates on two-dimensional (2-D) gels as a single spot with a pI of 6.7 +/- 0.2 and a molecular mass of 17,500 daltons. Concentrated solutions of rIL-1 beta have produced crystals by ammonium sulfate precipitation. The crystals are tetragonal, show the symmetry of space group P4(1) or its enantiomer, have lattice constants of a = 58.46 (1) and c = 77.02 (3) A, and scatter to at least 2 A resolution. A structure determination based on these crystals is under way.
A comprehensive digital protection method in very high voltage power systems (2002)

We have proposed a new design methodology to integrate digital protection relays. We have solved the timing problems involved with the conventional integrated protection systems. The proposed algorithms not only have led to an overall fast protection response, as well as integration advantages, but also have offered possibility of ommitting conventional different relays with their abnormal characteristics (CT saturation, restraint harmonic extraction, etc.).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Backbending phenomena in light nuclei at A∼60 (2006)

Recent studies of the backbending phenomenon in medium light weight nuclei near A∼ 60 expanded greatly our interest about how the single particle orbits are nonlinearly affected by the collective motion. As a consequence we have applied a modified version of the exponential model in mass region at A ∼ 60. A firm conclusion is obtained concerning the successful validity of the proposed modified model in describing the backbending phenomenon in this region. Comparison with different theoretical descriptions is discussed.
Terminal Platinum(II) Phosphido Complexes:  Synthesis, Structure, and Thermochemistry (1998)

A series of terminal Pt(II) phosphido complexes Pt(dppe)(Me)(PRR‘) (R = H; R‘ = Mes* (1), R‘ = Mes (2), R‘ = Ph (3), R‘ = Cy (4); R = R‘ = Mes (5); R = R‘ = Ph (6); R = R‘ = Cy (7); R = R‘ = Et (8); R = Ph, R‘ = i-Bu (9)) has been prepared by proton transfer from the appropriate phosphine to the methoxide ligand of Pt(dppe)(Me)(OMe) (10) (dppe = Ph2PCH2CH2PPh2; Mes* = 2,4,6-(t-Bu)3C6H2; Mes = 2,4,6-Me3C6H2; Cy = cyclo-C6H11). Complexes 1 and 2 were also made by deprotonation of the cations [Pt(dppe)(Me)(PH2Ar)][BF4] (Ar = Mes* (13); Ar = Mes (14)). For comparison to 1, the arylthiolate and aryloxide complexes Pt(dppe)(Me)(EMes*) (E = S (11); E = O (12)) were also prepared from 10. NMR studies of the proton-transfer equilibria between Pt(dppe)(Me)(X), Pt(dppe)(Me)(Y), and the acids HY and HX (see Bryndza, H. E.; Fong, L. K.; Paciello, R. A.; Tam, W.; Bercaw, J. E. J. Am. Chem. Soc. 1987, 109, 1444−1456 and Bryndza, H. E.; Domaille, P. J.; Tam, W.; Fong, L. K.; Paciello, R. A.; Bercaw, J. E. Polyhedron 1988, 7, 1441−1452) provide an approximate partial ranking of Pt−P bond strengths in this series: Pt−PHPh > Pt−PHMes > Pt−PHMes*; Pt−PPh2 > Pt−PMes2. Complementary solution calorimetry investigations probe the role of entropic effects on the equilibria. Both steric and electronic factors appear to be important in controlling relative Pt−P bond strengths. The Pt−S bonds in 11 and Pt(dppe)(Me)(SPh) are stronger than the analogous Pt−P bonds in 1 and 3. Complexes 1 and 5·THF were structurally characterized by X-ray crystallography.
A color graphics display of the field intensity around the insulator on 13.2 kV distribution lines (1993)

Covered conductors have been used, especially in wooded areas on low as well as high voltage overhead distribution lines for preventing brush contact and short circuit faults between conductors. Burndown on covered conductors has become a significant problem. The burndown mechanism is complicated since it is determined by combinations of the various types of insulators, ties, and conductors. In order to investigate the burndown mechanism, a finite element analysis is carried out to identify the electric field around the insulator. A newly developed electric field digital simulation system is reported in which a finite element analysis method considering isoparametric triangular and line elements is developed. A new color display method for electric potential and electric field distributions with lines of electric force is also described as a means of observing the results.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Wavelength-dependent optical degradation of green II–VI laser diodes (1999)

In this letter we report on optical degradation studies on BeMgZnSe separate confinement quantum well laser structures for the blue-green spectral region. The wavelength of the incident light has been tuned from 3.81 down to 2.10 eV, corresponding to an energy range from above the band gap of the cladding layers down to below the band gap of the quantum well. The dominant degradation mechanism is initiated when electron hole pairs are created in the quantum well. Absorption of light in deep defect bands, e.g., of the p-type cladding material is negligible in these structures. The strain state of the quantum well is one possible driving force for the degradation. In this context, point defect propagation as well as a structural phase transition of the ZnCdSe quantum well are discussed.
Droplet Sampling of an Oil-Based and Two Water-Based Antievaporant Ultra-Low Volume Insecticide Formulations Using Teflon (registered trademark)- and Magnesium Oxide-Coated Slides (2013)

Abstract : We estimated the diameters below which 50% and 90% of the volume of droplets exist (Dv50 and Dv90, respectively) of 1 oil-based (Permanone 30-30) and 2 water-based (AquaReslin, Aqua-KOthrine) antievaporant aerosols (with the Film Forming Aqueous Spray Technology [FFASTTM]) using TeflonH- and magnesium oxide (MgO)-coated slides and determined whether the aging of the droplets on the slides (up to 60 min) exhibited any significant effect on Dv50 and Dv90 calculations. There were no significant differences in either Dv50 or Dv90 estimates on MgO-coated slides at 0 min and 60 min for all 3 products tested. On Teflon-coated slides, the only product that showed significant difference between 0 min and 60 min in both Dv50 and Dv90 estimates was Aqua-K-Othrine, perhaps due to a difference in formulation components. Specifically, both values corresponding to Dv50 and Dv90 at 60 min decreased by approximately 50% when compared to the values at 0 min. For the other 2 products, AquaReslin and Permanone, aging of droplets on Teflon up to 60 min did not have any significant effect on Dv50 and Dv90 values. To further investigate the behavior of Aqua-K-Othrine droplets on Teflon-coated slides we observed the droplets immediately after spraying and at 10-min intervals under different conditions of temperature and humidity. The majority of the shrinkage occurred within the 1st 10 min after impaction on the slides under all conditions tested. So in most field situations where slides are read several hours or days after collection, this shrinkage would not be observed. The MgO-coated slides should be the preferred field method for sampling droplets of Aqua-K-Othirne with the FFAST antievaporant technology.
Acceleration of electrons with the racetrack nonscaling ffag for e-RHIC (2007)

The future relativistic electron hadron collider: e-RHIC requires acceleration of electrons to 10 GeV with a possible upgrade to 20 GeV. In the case that the super conducting linac is selected for acceleration, an energy recovery scheme is required. We propose to study a possibility of using the non-scaling Fixed-Field Gradient- Accelerator (NS-FFAG) for different energies. The beam will be accelerated by the superconducting linac at the top of the sine function, brought back to the front of the linac by the non-scaling FFAG and repeating this a few times until the total energy of 20 GeV is reached. After collisions the beam is brought back by the non-scaling FFAG and decelerated (on the lower RF phase) in the same sequence but in the reverse order. Conventional and non-conventional beam dynamic issues will be discussed, like the transit time matching effect and the time of flight adjustments.
Development of high-order segmented MEMS deformable mirrors (2012)

The areas of biological microscopy, ophthalmic research, and atmospheric turbulence correction require high-order DMs to obtain diffraction-limited images. Iris AO has been developing high-order MEMS DMs to address these requirements. Recent development has resulted in fully functional 489-actuator DMs capable of 9.5 µm stroke. For laser applications, the DMs were modified to make them compatible with high-reflectance dielectric coatings. Experimental results for the 489-actuator DMs with dielectric coatings shows they can be made with superb optical quality &lambda;/93.3 rms (11.4 nm rms) and &lambda;/75.9 rms (20.3 nm rms) for 1064 nm and 1540 nm coatings. Laser testing has demonstrated 300 W/cm2 power handling with off-the-shelf packaging. Power handling of 2800 W/cm2 is projected when incorporating packaging optimized for heat transfer.
Impact of drug resistance genotypes on CD4+ counts and plasma viremia in heavily antiretroviral‐experienced HIV‐infected patients (2005)

The number of HIV-infected individuals with prior multiple treatment failures is increasing as time passes by. The success of antiretroviral therapy in these patients is often compromised by the selection of drug-resistant viruses. Despite initial concerns, a rebound in AIDS cases among heavily treatment-experienced patients failing virologically their antiretroviral therapy has not occurred yet. In a multicenter study conducted in Spain, HIV-infected patients were assessed with prior failure to antiretrovirals from the three main drug families who presented during the last semester of the year 2003 with plasma HIV-RNA values above 1,000 copies/ml, despite good treatment adherence. The relationships between CD4+ T cell counts, viral loads and drug-resistant genotypes were examined. A total of 273 patients were identified in 12 centers (78% male, median age: 41 years). The mean viral load was 50,438 copies/ml and the mean CD4+ count was 328 cells/mul. Only 19.5% had less than 200 CD4+ T cells/mul. Most patients (95%) were receiving nucleoside reverse transcriptase inhibitors (NRTI) in their last antiretroviral regimen, while 63% were treated with protease inhibitors (PI) and 27% on non-nucleoside reverse transcriptase inhibitors (NNRTI). Overall, 97.4% had at least one drug resistance mutation (87.2% for NRTI, 68.5% for NNRTI, and 92.7% for PI). Using the virtual phenotype, resistance to three or more drugs within each class was recognized in 45.8% for NRTI, 40.7% for NNRTI, and 44.7% for PI. Moreover, cross-resistance to compounds from two or three drug families was recognized in 41% and 19.4% of patients, respectively. Nearly half of the patients had plasma HIV-RNA below 10,000 copies/ml and they showed significantly higher CD4 + counts than those with greater viremia (408 versus 259 cells/mul; P < 0.001). Patients with higher plasma viremia had significantly more drug resistance mutations than those with lower viremia. No favorable effect on viral load could be recognized for individual drug resistance mutations known to reduce viral fitness in vitro (i.e., rtM184V, rtL74V, rtK65R, proD30N, or proI50L). In summary, a large proportion of treatment-experienced patients failing their current antiretroviral regimen carry viruses with broad cross-resistant genotypes. Nearly half of the patients with these multi-drug resistant viruses had < 10,000 HIV-RNA copies/ml and 80% have more than 200 CD4 + T cells/mul. Thus, maintaining treatment HIV-infected individuals failing virologically and harboring drug-resistant viruses might ameliorate immunological deterioration until new drugs became available. J. Med. Virol. 77:23-28, 2005. (c) 2005 Wiley-Liss, Inc.
Recommendations for authors of manuscripts reporting inhibitor cases developed in previously treated patients with hemophilia: communication from the SSC of the ISTH (2016)

Aim The scope of this recommendation is to provide guidance for reporting of inhibitor cases in previously treated patients (PTPs) with hemophilia A. This guidance is intended to improve transparency and completeness of reporting of observed events; it does not cover planning, executing or analyzing original studies aimed at the assessment of inhibitor rates. Recommendation We recommend that for each case of inhibitor development reported in a published paper, a paragraph or a table is included in the main publication reporting as a minimum the underlined data fields in Table . We recommend transparent reporting when any of the suggested information is not available. We recommend that particular care is used in reporting the timeline of events by clearly identifying a reference time-point. We suggest that journals in the field adopt this guidance as instructions for the authors and as a guide for reviewers. Conclusion Development of inhibitors in PTPs is a very rare event. Standardized reporting of inhibitor characteristics will contribute to generating a body of evidence otherwise not available. Case by case reporting of the recommended data elements may shed light on the natural history and risk factors of inhibitor development in PTPs and be useful for tailoring care in similar future cases.
Utilisation of the “FAST” indicator in follow-up of children with implanted pacemakers (2001)

Heart rate variability (HRV) evaluates the autonomic modulation on sinus node and is age-related in children. In pediatric patients (pts), permanent pacing is performed by WlR and DDD pacemakers (PM) according to pts age, Aim of the study is to compare heart rate (HR) and HRV in pts with WlR (activity sensor) and DDD PM for congenital or post-surgical complete A-V block and in age-matched controls. Children were divided in 4 groups: I, 16 pts with WIR PM; II, 51 controls; III, 10 pts with DDD; IV, 51 controls. All children underwent echocardiography that showed normal ventricular dimensions and function in all children, and 24-hour Holter monitoring to evaluate mean, max and rain HR and time-domain indexes of HRV (sdnn, sdnni, sdann) in the whole registration and, only dunng wake hours, in groups I-A (5 pts with WIR PM) and II-A (6 controls). Statistical analysis was performed by t test (p<0.05 significant) in age-matched groups. WIR PMs were programmed with rain HR 76+7 bpm, max HR 168+13 bpm, activity parameters at medium values; DDD PMs rain. HR 67+17 bpm e max. tracking rate 163+9 bpm.
&lt;title&gt;Electro-optical approach to pavement deflection management&lt;/title&gt; (1995)

A prototype continuous deflection device, referred to as a rolling weight deflectometer (RWD), has been developed as a nondestructive evaluation tool for airfield pavements. The system consists of a rigid trailer equipped with specially designed optical triangulation pavement sensors, a high-speed data acquisition system, and a high-pressure tire/load platform assembly. Pavement sensors are mounted on a rigid box beam equipped with an internal sensor system that corrects, in real time, the relative pavement height position measurements for displacements induced in the beam by mechanical vibrations, changes in temperature, or nonuniform dynamic loads at points where the beam attaches to the frame. The device produces continuous deflection profiles that show pavement response to a moving loaded wheel along the path of travel. These deflection profiles, combined with multiple passes along a lane, provide a far more detailed picture of the pavement structural integrity than has ever before been possible, because existing evaluation tools only produce response information at discrete points. Preliminary results show deflections measured by the RWD are in general agreement with the expected pavement response for various loads. A discussion of the device configuration, preliminary data, and potential as a pavement management tool is presented.