gebhart/patrepeval huggingface dataset:
P010. OnabotulinumtoxinA for treatment of chronic migraine: results after 1 year of treatment (2015)

OnabotulinumtoxinA (OnabotA) was approved for treatment of chronic migraine (CM) following the PREEMPT trials[1, 2], and was licensed in Italy in February 2013. Thus, in December 2013 we began to offer OnabotA to patients with CM who did not respond to other preventive therapy (mostly topiramate, beta blockers, amitriptyline and calcium channel antagonists). Demographic and migraine characteristics of patients were recorded, and changes in monthly migraine days and headache intensity (the latter variable was evaluated only after the first session of treatment), as well as, the number of symptomatic medications intake, were assessed. From December 2013, 40 patients (9 males, 31 females) were treated with at least four therapeutic sessions. Their mean age (± SD) at treatment onset was 51.3±12.6 years (range: 27-80). All the patients fulfilled the ICHD-III criteria for CM[3] and 28 (70%) were receiving other preventive therapy. In 34 of these patients (85%) overuse of symptomatic medications was observed at the onset of treatment. After obtaining an informed consent, we administered OnabotA according to the PREEMPT protocol (155 UI for a total of 31 injections divided across 7 head/neck muscles), performing no additional injections in the first session (from the second session we also adopted “follow the pain” protocol), and we gave the patients a paper diary to register the headache evolution. After one year of treatment we analyzed the data related to the 40 patients, observing positive results in all the variables considered. In particular, following 1-year treatment there was a reduction from 25.1±6.1 to 19.8±9.1 in the mean (± SD) number of monthly migraine days (reduction of 21%, p < 0.0001). The intake of symptomatic medications was reduced of about 12%, but the difference was not statistically significant. Most (78%) of the patients (n = 23) who had accurately registered the data reported that the greatest clinical benefit of OnabotA was the reduction in the headache intensity. Finally, no severe adverse event was observed, and mild pain in the injection site was the most reported experience. No patient discontinued the treatment because of side effects. We can conclude that the use of OnabotA according to the PREEMPT paradigm is an effective and well-tolerated treatment in patients with chronic migraine in a real-life setting.

Written informed consent to publication was obtained from the patient(s).
The Effect of Protein II and Pili on the Interaction of Neisseria gonorrhoeae with Human Polymorphonuclear Leucocytes (1986)

Colonial variants of Neisseria gonorrhoeae strain P9 expressing different pili and/or outer membrane protein II (P.II) were investigated with respect to their interaction with human polymorphonuclear leucocytes (PMN). Two assay systems were used. A phagocytic killing assay measured the intracellular survival of gonococci, and PMN chemiluminescence (CL) was used to determine the initial surface interactions. All variants expressing P.II were killed effectively by PMN and also greatly stimulated PMN CL. The P.II- variants, on the other hand, were resistant to phagocytic killing and stimulated a much lower CL response. The presence of different P.II species was associated with different CL profiles and therefore different modes of interaction with the PMN membrane. A P.II-specific monoclonal IgG was opsonic and greatly increased PMN CL in contrast to F(ab')2 prepared from the same antibody, which inhibited it, thus confirming the role of P.II in the PMN interaction. Phagocytic killing assays revealed that with the loss of P.II, gonococcal variants acquired resistance to killing. Comparison of piliated and non-piliated pairs of variants with the same P.II profile showed that PMN-gonococcal interactions are dominated by the nature of the P.II species present whereas pili have little effect.
Effects of Operational Variability on Heavy-Duty Truck Greenhouse Gas Emissions (2010)

Heavy-duty diesel trucks are critical to goods movement in the United States and their demand is expected to increase significantly in the near future. Although diesel engines are more fuel efficient than their gasoline counterpart, their abundant use in the freight transportation sector makes them a significant source of carbon dioxide (CO2), the most significant anthropogenic greenhouse gas (GHG). With the increasing concern over limiting GHG emissions, much attention has been put on heavy duty trucks and improving their fuel economy as well as reducing their CO2 emissions. Most of the focus to date has been placed on specific vehicle technology and alternative fuels. However, another key area that is often overlooked is operational variability associated with heavy duty truck use and how vehicle operation can be modified to reduce CO2. This paper examines some of these truck operational variables including vehicle speed, road grade, vehicle weight, and roadway facility type. To examine these variables, we have collected a large amount of on-road heavy-duty truck data using a state-of-the-art mobile emission laboratory. This lab collects real-world fuel economy and emissions data for a variety of driving conditions. In addition, a state-of-the-art modal emission model for heavy duty diesel trucks is utilized in the analysis.
Supplementary Data from Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2 (2023)

Supplementary Data from Escape from hsa-miR-519c enables drug-resistant cells to maintain high expression of ABCG2
A Method of A Behavior Suggestion System using ECG Monitor and Accelerometer (2021)

In recent years, the wearable computing equipped with several sensors built into a small microcomputer has been attracting people’s attention, and various information and data are acquired from people. In this paper, a novel behavior suggestion system using a small microcomputer connected with an ECG (Electrocardiograph) monitor and an accelerometer is proposed.
A performance analysis of single versus multiple processors (2005)

We consider a simple model of a multiprocessor digital system, with three main ingredients: a load of different transaction types with given arrival statistics, an architecture consisting of a network of loosely coupled nodes with tightly coupled symmetric multiple processors at each node, and a load partitioning or assignment of each step of execution of each transaction type to a given node. In order to quantify this problem, we adopt a Jackson network for ease of analysis. Our goal is to consider tradeoffs between the workload, the architecture, and workload partitioning to maximize performance. We measure performance by two indices, the mean throughput rate of completing each tran saction type, and the mean response time to completely execute each transaction type. We present analytic formulae for the mean response time for a job assuming simple Poisson arrival statistics. To illustrate the many tradeoffs possible, we consider one example in detail. We show that if we fix the total mean instruction rate, the mean response time for the multiprocessor network is always greater than the mean response time for a job submitted to one equivalent fast processor. In the special case of purely random arrivals and equalutilization of all network nodes, the mean response time will be at least N times that of a single equivalent fast processor. Moreover, the optimum assignment of excess processing capacity to each node to minimize mean response time does not obey a simple linear proportionment based on utilization, but rather a square root assignment of excess capacity. This model accounts for randomness in arrival and service patterns. Significant features left out of this analysis are the system overhead in coordinating all the multiprocessor interactions, memory contention, and so forth, which presumably will only further degrade performance. In many applications, other issues, such as flexibility, reliability, cost, and so forth, may play a dominant role in a design decision; here we concentrate solely on the system response time as the performance measure, with a fixed total instruction rate.
Complete genome sequence of “Enterobacter lignolyticus” SCF1 (2011)

In an effort to discover anaerobic bacteria capable of lignin degradation, we isolated "Enterobacter lignolyticus" SCF1 on minimal media with alkali lignin as the sole source of carbon. This organism was isolated anaerobically from tropical forest soils collected from the Short Cloud Forest site in the El Yunque National Forest in Puerto Rico, USA, part of the Luquillo Long-Term Ecological Research Station. At this site, the soils experience strong fluctuations in redox potential and are net methane producers. Because of its ability to grow on lignin anaerobically, we sequenced the genome. The genome of "E. lignolyticus" SCF1 is 4.81 Mbp with no detected plasmids, and includes a relatively small arsenal of lignocellulolytic carbohydrate active enzymes. Lignin degradation was observed in culture, and the genome revealed two putative laccases, a putative peroxidase, and a complete 4-hydroxyphenylacetate degradation pathway encoded in a single gene cluster.
A New Magneto-Rheological Brake for Haptic Applications (2011)

This paper proposes a new brake featuring magneto-rheological (MR) fluid. The outstanding feature of the proposed MR brake is the possibility of compensating for the passive friction completely. It consists of two coils, one quasi-stator and two rotors. These rotors are in relatively reverse rotation mode. After a configuration of this brake is proposed, an optimization procedure based on integrated finite element analysis (FEA) and Particle Swarm Optimization (PSO) algorithm is developed to obtain its geometric dimensions. Then, the simulated performance of the optimized brake is shown with remarkable discussions.
Advancing Chelation Chemistry for Actinium and Other +3 f-Elements, Am, Cm, and La (2019)

A major chemical challenge facing implementation of <sup>225</sup>Ac in targeted alpha therapy-an emerging technology that has potential for treatment of disease-is identifying an <sup>225</sup>Ac chelator that is compatible with <i>in vivo</i> applications. It is unclear how to tailor a chelator for Ac binding because Ac coordination chemistry is poorly defined. Most Ac chemistry is inferred from radiochemical experiments carried out on microscopic scales. Of the few Ac compounds that have been characterized spectroscopically, success has only been reported for simple inorganic ligands. Toward advancing understanding in Ac chelation chemistry, we have developed a method for characterizing Ac complexes that contain highly complex chelating agents using small quantities (μg) of <sup>227</sup>Ac. We successfully characterized the chelation of Ac<sup>3+</sup> by DOTP<sup>8-</sup> using EXAFS, NMR, and DFT techniques. To develop confidence and credibility in the Ac results, comparisons with +3 cations (Am, Cm, and La) that could be handled on the mg scale were carried out. We discovered that all M<sup>3+</sup> cations (M = Ac, Am, Cm, La) were completely encapsulated within the binding pocket of the DOTP<sup>8-</sup> macrocycle. The computational results highlighted the stability of the M(DOTP)<sup>5-</sup> complexes.
Electroencephalogram-Based Methodology for Determining Unconsciousness During Depopulation (2012)

When an avian influenza or virulent Newcastle disease outbreak occurs within commercial poultry, key steps involved in managing a fast-moving poultry disease can include: education; biosecurity; diagnostics and surveillance; quarantine; elimination of infected poultry through depopulation or culling, disposal, and disinfection; and decreasing host susceptibility. Available mass emergency depopulation procedures include whole-house gassing, partial-house gassing, containerized gassing, and water-based foam. To evaluate potential depopulation methods, it is often necessary to determine the time to the loss of consciousness (LOC) in poultry. Many current approaches to evaluating LOC are qualitative and require visual observation of the birds. This study outlines an electroencephalogram (EEG) frequency domain-based approach for determining the point at which a bird loses consciousness. In this study, commercial broilers were used to develop the methodology, and the methodology was validated with layer hens. In total, 42 data sets from 13 broilers aged 5-10 wk and 12 data sets from four spent hens (age greater than 1 yr) were collected and analyzed. A wireless EEG transmitter was surgically implanted, and each bird was monitored during individual treatment with isoflurane anesthesia. EEG data were evaluated using a frequency-based approach. The alpha/delta (A/D, alpha: 8-12 Hz, delta: 0.5-4 Hz) ratio and loss of posture (LOP) were used to determine the point at which the birds became unconscious. Unconsciousness, regardless of the method of induction, causes suppression in alpha and a rise in the delta frequency component, and this change is used to determine unconsciousness. There was no statistically significant difference between time to unconsciousness as measured by A/D ratio or LOP, and the A/D values were correlated at the times of unconsciousness. The correlation between LOP and A/D ratio indicates that the methodology is appropriate for determining unconsciousness. The A/D ratio approach is suitable for monitoring during anesthesia, during depopulation, and in situations where birds cannot be readily viewed.
Optical characterization of CuIn1−xGaxSe2 alloy thin films by spectroscopic ellipsometry (2003)

Optical constants of polycrystalline thin film CuIn1−xGaxSe2 alloys with Ga/(Ga+In) ratios from 0 to 1 have been determined by spectroscopic ellipsometry over an energy range of 0.75–4.6 eV. CuIn1−xGaxSe2 films were deposited by simultaneous thermal evaporation of elemental copper, indium, gallium and selenium. X-ray diffraction measurements show that the CuIn1−xGaxSe2 films are single phase. Due to their high surface roughness, the films are generally not suitable for ellipsometer measurements. A method is presented in which spectroscopic ellipsometer measurements were carried out on the reverse side of the CuIn1−xGaxSe2 films immediately after peeling them from Mo-coated soda lime glass substrates. A detailed description of multilayer optical modeling of ellipsometric data, generic to ternary chalcopyrite films, is presented. Accurate values of the refractive index and extinction coefficient were obtained and the effects of varying Ga concentrations on the electronic transitions are presented.
Low-Carbon-Steel Corrosion at High Temperatures by Aminopolycarboxylic Acids (2017)

Summary Aminopolycarboxylic acids (APCAs) have been used in a variety of applications ranging from textiles to pharmaceuticals. They are also commonly used in the oil-and-gas industry for scale removal, standalone stimulation, and iron control. Because of the commonplace usage of APCAs, it is important to understand the corrosion that can result from the use of APCAs and the methods that can be applied to reduce corrosion damage resulting from their use. The objective of this work is to evaluate the corrosion rate of APCAs on low-carbon steel at high temperatures and to determine the mechanism of corrosion. At high temperatures, conventional acids such as hydrochloric acid (HCl) are extremely corrosive, lack penetration, and have sludging tendencies. Several organic acids such as formic acid and citric acid were proposed to overcome these shortcomings. However, these organic acids have displayed problems with solubility and compatibility. Chelating agents show good dissolving power, low corrosion, low sludging tendencies, and excellent iron control, and have been successfully used to replace HCl in certain applications. Furthermore, some of them are easily biodegradable and environmentally friendly. To study the mechanism of corrosion at high temperature, N-80 coupons were exposed to APCA solutions for 12 hours in the absence of corrosion inhibitors (CIs). At 350°F, the corrosion rate of ethylenediamine tetraacetic acid (EDTA), L-glutamic diacetic acid (GLDA), hydroxyethyl ethylene triacetic acid (HEDTA), and methylglycine diacetic acid (MGDA) had corrosion rates of 1.07, 0.754, 0.974, and 0.76 lbm/ft2, respectively. When the temperature was lowered to 300°F, the corrosion rates of each chelating agent decreased to 0.858, 0.724, 0.803, and 0.642 lbm/ft2 for EDTA, GLDA, HEDTA, and MGDA, respectively. The addition of a 1-vol% sulfur-containing CI to HEDTA and MGDA tests at 350°F caused a significant decrease in corrosion rates to 0.0102 and 0.00561 lbm/ft2, respectively. Furthermore, the mechanism of the APCA corrosion of low-carbon steel was found to be a combination of chelant-enhanced dissolution and cathodic reduction of the APCA. Chelant-enhanced dissolution involves the dissolution of the oxide layer on the surface of the metal, and is accelerated at high temperatures by reductive dissolution. Cathodic reduction of carboxylic-acid groups of APCAs was determined to be responsible for the corrosion of the bare metal layer.
The Benefits of Going Small: Nanostructures for Mammalian Cell Transfection (2020)

Nanostructures, with their localized interactions with mammalian cells, can offer better efficiency and lower cell perturbation than conventional viral, biochemical, and electroporation transfection techniques. In this Perspective, I describe the different stages of transfection and provide a comparison of transfection techniques based on their mechanisms. Focusing on specific aims of transfection, I also illustrate how recent developments in high-aspect-ratio nanostructures have endowed them with properties that are superior to existing viral, biochemical, and electroporation methods as a versatile technique to deliver a variety of cargoes and to interface with different mammalian cell types for biomedical applications. Finally, I describe the challenges associated with transfection that need to be overcome to enhance cargo delivery efficiency and clinical translation.
Data from Longitudinal SARS-CoV-2 mRNA Vaccine-Induced Humoral Immune Responses in Patients with Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Longitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we measured antibody levels [anti-spike (IgG-(S-RBD) and anti-nucleocapsid immunoglobulin] at three time points. Antibody level trajectories and frequency of breakthrough infections were evaluated by tumor type and timing of treatment relative to vaccination. IgG-(S-RBD) at peak response (median = 42 days after dose 2) was higher (&lt;i&gt;P&lt;/i&gt; = 0.002) and remained higher after 4 to 6 months (&lt;i&gt;P&lt;/i&gt; = 0.003) in patients receiving mRNA-1273 compared with BNT162b2. Patients with solid tumors attained higher peak levels (&lt;i&gt;P&lt;/i&gt; = 0.001) and sustained levels after 4 to 6 months (&lt;i&gt;P&lt;/i&gt; &lt; 0.001) compared with those with hematologic malignancies. B-cell targeted treatment reduced peak (&lt;i&gt;P&lt;/i&gt; = 0.001) and sustained antibody responses (&lt;i&gt;P&lt;/i&gt; = 0.003). Solid tumor patients receiving immune checkpoint inhibitors before vaccination had lower sustained antibody levels than those who received treatment after vaccination (&lt;i&gt;P&lt;/i&gt; = 0.043). Two (0.69%) vaccinated and one (1.9%) unvaccinated patient had severe COVID-19 illness during follow-up. Our study shows variation in sustained antibody responses across cancer populations receiving various therapeutic modalities, with important implications for vaccine booster timing and patient selection.&lt;/p&gt;Significance:&lt;p&gt;Long-term studies of immunogenicity of SARS-CoV-2 vaccines in patients with cancer are needed to inform evidence-based guidelines for booster vaccinations and to tailor sequence and timing of vaccinations to elicit improved humoral responses.&lt;/p&gt;&lt;/div&gt;
Probing Ca[sup +] ions in a miniature trap (1999)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation M. Knoop, M. Vedel, M. Houssin, T. Schweizer, T. Pawletko, F. Vedel; Probing Ca+ ions in a miniature trap. AIP Conf. Proc. 15 January 1999; 457 (1): 365–368. https://doi.org/10.1063/1.57478 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Molecular scanning for mutations in the beta 3-adrenergic receptor gene in Nauruans with obesity and noninsulin-dependent diabetes mellitus. (1996)

We recently identified a mutation in the human P,-adrenergic receptor (p&R) gene (codon 64 Z'GG-+ CGGhg;
H1(0) histone and differentiation of dendritic cells. A molecular target for tumor-derived factors. (2002)

Dendritic cells (DC) play a central role in antitumor immune responses. Abnormal differentiation of DC and their inability to stimulate T cells are important factors in tumor escape from immune-system control. However, the mechanisms of this process remain elusive. Here, we have described one possible molecular mechanism that involves replacement linker histone H1 (0). A close association between expression of H1(0) and DC differentiation in vitro has been found. DC production in H1(0) -deficient mice was decreased significantly, whereas generation and function of macrophages, granulocytes, and lymphocytes appear to be normal. However, these mice had a significantly reduced response to vaccination with antigens. Tumor-derived factors considerably reduced H1(0) expression in hematopoietic progenitor cells. We have demonstrated that transcription factor NF-kappaB is involved actively in regulation of H1(0). Thus, H1(0) histone may be an important factor in normal DC differentiation. Tumor-derived factors may inhibit DC differentiation by affecting H1(0) expression.
Enhancement of THz EO Sampling Signal by Polarization Filtering (2018)

To improve the detection efficiency of electro-optic (EO) sampling of terahertz waves, we propose “polarization filtering,” where the main polarization component of the probe optical beam is suppressed after the interaction in the EO crystal. Experimentally, we achieved a factor of 2.4 increase in the EO sampling signal by the polarization filtering.