gebhart/patrepeval huggingface dataset:
Autism Spectrum Disorders and Mastocytosis (2009)

Autism Spectrum Disorders (ASD) are diagnosed in early childhood and include Autism, Asperger's disorder and Pervasive neurodevelopmental disorder--not otherwise specified (PDD-NOS, or atypical autism). ASD are associated with varying degrees of dysfunctional communication and social skills, repetitive and stereotypic behaviors, as well as attention and learning disabilities. Most ASD patients also have food intolerance and other allergic symptomatology indicative of mast cell activation. The number of ASD cases have increased over the last decade to 1/100, but there is no definite pathogenesis or curative therapy. We report that the apparent prevalence of ASD in patients with mastocytosis, a rare disease occurring in 1/4,000 children and characterized by an increased number of hypersensitive mast cells in many organs, is about 1/10 or 10 times higher than the general population. A child with skin mastocytosis (urticaria pigmentosa), and regressive autism is presented to illustrate the point. Allergic, infectious, neuroimmune and environmental triggers may activate mast cells to release vasoactive, inflammatory and neurotoxic molecules. These could disrupt the gut-blood-brain-barriers, and/or activate susceptibility genes, thus contributing to brain inflammation and ASD.
Promoter‐specific alterations of <i>APC</i> are a rare cause for mutation‐negative familial adenomatous polyposis (2014)

n familial adenomatous polyposis (FAP), 20% of classical and 70% of attenuated/atypical (AFAP) cases remain mutation-negative after routine testing; yet, allelic expression imbalance may suggest an APC alteration. Our aim was to determine the proportion of families attributable to genetic or epigenetic changes in the APC promoter region. We studied 51 unrelated families/cases (26 with classical FAP and 25 with AFAP) with no point mutations in the exons and exon/intron borders and no rearrangements by multiplex ligation-dependent probe amplification (MLPA, P043-B1). Promoter-specific events of APC were addressed by targeted resequencing, MLPA (P043-C1), methylation-specific MLPA, and Sanger sequencing of promoter regions. A novel 132-kb deletion encompassing the APC promoter 1B and upstream sequence occurred in a classical FAP family with allele-specific APC expression. No promoter-specific point mutations or hypermethylation were present in any family. In conclusion, promoter-specific alterations are a rare cause for mutation-negative FAP (1/51, 2%). The frequency and clinical correlations of promoter 1B deletions are poorly defined. This investigation provides frequencies of 1/26 (4%) for classical FAP, 0/25 (0%) for AFAP, and 1/7 (14%) for families with allele-specific expression of APC. Clinically, promoter 1B deletions may associate with classical FAP without extracolonic manifestations.
Options for a New Arizona Observatory: Configurations, Costs and Site (1984)

This paper is concerned with the process of creating a major observatory at minimum cost. Its premises are that cost optimization starts with an appropriately modestly priced building block, a 7.5m telescope. There are many possible configurations in which this building block can be used, ranging from a single telescope or a set of separate telescopes with at most electronic data addition, to an MMT in which the light of all telescopes can be phased when desired. In addition there are options for using elements in a non-redundant linear array or Michelson inteferometer. We provide the reader with a means of estimating costs of different facilities all on the same basis, and tied to the actual cost of producing the MMT. It is also important to place the observatory on a site which maximizes the output per unit cost of the facility. We discuss the selection process which has led to Mt. Graham in Arizona as being likely to satisfy this criterion. We give brief details of our preliminary knowledge about the site.
Natural fracture systems studies (1992)

The objectives of this program are (1) to develop a basinal-analysis methodology for natural fracture exploration and exploitation, and (2) to determine the important characteristics of natural fracture systems for use in completion, stimulation, and production operations. Natural-fracture basinal analysis begins with studies of fractures in outcrop, core and logs in order to determine the type of fracturing and the relationship of the fractures to the lithologic environment. Of particular interest are the regional fracture systems that are pervasive in western US tight sand basins. A Methodology for applying this analysis is being developed, with the goal of providing a structure for rationally characterizing natural fracture systems basin-wide. Such basin-wide characterizations can then be expanded and supplemented locally, at sites where production may be favorable. Initial application of this analysis is to the Piceance basin where there is a wealth of data from the Multiwell Experiment (MWX), DOE cooperative wells, and other basin studies conducted by Sandia, CER Corporation, and the USGS (Lorenz and Finley, 1989, Lorenz et aI., 1989, and Spencer and Keighin, 1984). Such a basinal approach has been capable of explaining the fracture characteristics found throughout the southern part of the Piceance basin and along the Grand Hogback.
Diminished Electron Transfer Kinetics for [Ru(NH<sub>3</sub>)<sub>6</sub>]<sup>3+/2+</sup>, [α-SiW<sub>12</sub>O<sub>40</sub>]<sup>4–/5–</sup>, and [α-SiW<sub>12</sub>O<sub>40</sub>]<sup>5–/6–</sup> Processes at Boron-Doped Diamond Electrodes (2015)

Heterogeneous electron transfer rate constants (k0 values) at a boron-doped diamond (BDD) electrode (10–2 cm s–1 range) that are more than an order of magnitude smaller than found at metal or glassy carbon (GC) electrodes (≥2.0 cm s–1) are reported for the outer-sphere [Ru(NH3)6]3+/2+, [α-SiW12O40]4–/5–, and [α-SiW12O40]5–/6– redox couples in aqueous electrolyte media. The k0 values and other parameters relevant to electrode kinetics were derived from analysis of the higher-order harmonic components available in Fourier transformed large amplitude alternating current voltammetry at BDD, GC, and platinum (Pt) or gold (Au) electrodes for the reduction of highly positively charged [Ru(NH3)6]3+ and highly negatively charged Keggin-type silicon tungstate ([α-SiW12O40]4– and [α-SiW12O40]5–). The slower electron transfer kinetics at the BDD electrode, relative to the other electrode materials, are discussed in terms of the double layer, density of states, and other factors.
Cover Picture: Matter‐Wave Metrology as a Complementary Tool for Mass Spectrometry (Angew. Chem. Int. Ed. 33/2008) (2008)

An artist's view …︁ of the matter-wave interferometer for large molecules is shown in the cover picture: the three-grating arrangement is seen through the window of the vacuum chamber. The molecular model in the foreground is a compound studied in the experiments reported by K. Hornberger, M. Mayor, M. Arndt et al. in their Communication on page 6195 ff. The compound's fragmentation behavior can be analyzed using quantum interferometry.
In situ accelerated degradation of polyoxyethylene/poly(ε-caprolactone) multiblock copolymer by moderate thermal treatment (2003)

Alternating amphiphilic multiblock copolymers, consisting of polyoxyethylene (POE) and poly(epsilon-caprolactone) (PCL) of various lengths, were synthesized by a polycondensation reaction between dicarboxylated PEG and dihydroxyl PCL. The polymer formed a physical hydrogel by PCL crystallization. For in vitro hydrolysis in phosphate-buffered saline solution, the change of molecular weight depended on the composing block length of POE. The polymer with longer POE showed a faster decline in molecular weight. The mass remaining at the end of two weeks at 25 degrees C was more than 95 w%. However, when the swollen hydrogels were exposed to temperatures slightly above PCL melting point for 30 min, the degradation rate was accelerated and the mass remaining dropped to less than 10 wt% in one week. In vivo degradation after hydrogel implantation, the polymer degraded as under in vitro. However, the implant irradiated with infrared (IR) accelerated its degradation similar to a treatment with elevated temperature.
Structural Basis for Peptidomimicry by the Effector Element of Rapamycin (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationStructural Basis for Peptidomimicry by the Effector Element of RapamycinYoshi Odagaki and Jon ClardyView Author Information Department of ChemistryBaker Laboratory Cornell University, Ithaca, New York 14853-1301 Cite this: J. Am. Chem. Soc. 1997, 119, 42, 10253–10254Publication Date (Web):October 22, 1997Publication History Received25 June 1997Published online22 October 1997Published inissue 1 October 1997https://pubs.acs.org/doi/10.1021/ja972098whttps://doi.org/10.1021/ja972098wrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views308Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical structure,Fluorescence recovery after photobleaching,Hydrophobicity,Ligands,Peptides and proteins Get e-Alerts
The serotonin 5-HT2A and 5-HT3 receptors mediate cat urinary bladder contraction in vivo (2002)

Stress incontinence and overactive bladder are disorders with a common symptom, urinary incontinence, which is a serious medical and social handicap. Several neurotransmitters regulate the function of the lower urinary tract, including noradrenaline, acetylcholine, and serotonin.The present study is part of the search for pharmacological incontinence drugs. The aims of this thesis were to improve the existing pharmacological treatments of urinary incontinence and to look for alternative treatments: i) an α1-adrenergic agonist that preferentially affects urethral over blood pressure was tested in vivo; ii) a modified cystometry model was developed for screening of muscarinic antagonists, by construction of a complete dose-response curve in each individual animal; iii) a new muscarinic antagonist, PNU-171990, was pharmacologically characterized in vitro and in vivo; iv) functional differences of the isomers of the muscarinic agonist BM-5 were characterized in the urinary bladder and ileum, in vitro and in vivo; v) the role of serotonin 5-HT2A, 5-HT3 and 5-HT4 receptors were characterized on urinary bladder contractions in vivo.In the search for urethra selective compounds, the α1-adrenoceptors agonists phenylephrine and phenylpropanolamine selectively enhanced blood pressure as compared to the urethral pressure in rabbit. This is in contrast to the effect of oxymetazoline and NS-49. Muscarinic antagonists produced a dose-dependent inhibition of the volume-induced micturition pressure in the rat. PNU-171990, a non-selective muscarinic antagonist, revealed selectivity for urinary bladder pressure over salivation (P<0.05). (R)-BM-5 induced bladder contraction and saliva secretion in cats. The selective serotonin 5-HT2A and 5-HT3 receptor antagonists, ketanserin and tropisetron, both inhibited the effect of chemically induced bladder contraction in the anaesthetized cat.In conclusion, an urethral-selective α1A-adrenoceptor agonist may be a good treatment of stress incontinence. A bladder-selective competitive muscarinic antagonist is considered a good pharmacotherapy for overactive bladder. In addition, the 5-HT2A and 5-HT3 receptor antagonist may improve lower urinary tract symptoms.
Real-Time Blind Photonic Interference Cancellation for mmWave MIMO (2023)

Multiple-input multiple-output (MIMO) mmWave devices broadcast multiple spatially-separated data streams simultaneously in order to increase data transfer rates. Data transfer can, however, be compromised by interference. Conventional techniques for mitigating interference require additional space and power not generally available in handheld mobile devices. Here, we propose a photonic mmWave MIMO receiver architecture capable of interference cancellation with greatly reduced space and power needs. We demonstrate real-time photonic interference cancellation with an integrated FPGA-photonic system that executes a novel zero-calibration micro-ring resonator control algorithm. The system achieves sub-second cancellation weight determination latency with sub-Nyquist sampling. We evaluate the impact of canceller design parameters on performance, establishing that effective photonic cancellation is possible in handheld devices with less than 30 ms weight determination latency.
Mutational Signatures in Mandibular Ameloblastoma Correlate with Smoking (2019)

Ameloblastoma is a rare tumor of odontogenic epithelium, the low incidence rate of which precludes statistical determination of its molecular characterizations. Despite recent genomic and transcriptomic profiling, the etiology of ameloblastomas remains poorly understood. Risk factors of ameloblastoma development are also largely unknown. Whole exome sequencing was performed on 11 mandibular ameloblastoma samples. We identified 2 convergent mutational signatures in ameloblastoma: 1) a signature found in multiple types of lung cancers with probable etiology of tobacco carcinogens (COSMIC signature 4) and 2) a signature present in gingivobuccal oral squamous cell carcinoma and correlated with tobacco-chewing habits (COSMIC signature 29). These mutational signatures highlight tobacco usage or related mutagens as one possible risk factor of ameloblastoma, since the association of BRAF mutations and smoking was demonstrated in multiple studies. In addition to BRAF hotspot mutations (V600E), we observed clear inter- and intratumor heterogeneities. Interestingly, prior to BRAF mutation, important genes regulating odontogenesis mutated (e.g., corepressor BCOR), possibly playing important roles in tumorigenesis. Furthermore, recurrent mutations in the CDC73 gene, the germline mutations of which predispose patients to the development of jaw tumors, were found in 2 patients, which may lead to recurrence if not targeted by therapeutic drugs. Our unbiased profiling of coding regions of ameloblastoma genomes provides insights to the possible etiology of mandibular ameloblastoma and highlights potential disease risk factors for screening and prevention, especially for Asian patients. Because of the limited sample size and incomplete habitual, dietary, and occupational data, a causal link between tobacco usage and ameloblastoma still requires further investigations.
Heavy Metals, Pesticide, Plasticizers Contamination and Risk Analysis of Drinking Water Quality in the Newly Developed Housing Societies of Gujranwala, Pakistan (2022)

The supply of clean drinking water is essential for a healthy life, but access to safe and healthy drinking water has become a key issue worldwide, especially in developing nations such as Pakistan. This research work focused on investigating the suitability of groundwater by measuring quality parameters, identification of pesticide pollutants, and health risk analysis in adults and children due to the consumption of groundwater in recently developed housing societies of the Gujranwala district, Punjab, Pakistan. Drinking water samples (n = 200) were collected from electric water pumps and analyzed by in situ testings following the Standard American Public Health Association (APHA) methods. Pesticides and plasticizers detection was carried out using gas chromatography-mass spectrometry (GC/MS). Results showed that the concentrations of dissolved Cr and Pb at more than 20% of sampling sites exceeded the allowable limit of the World Health Organization (WHO). However, the measured physico-chemical attributes and concentrations of Fe and Zn did not exceed their respective permissible limits. The most abundant pollutants detected were plasticizers (30); followed by herbicides (21); fungicides, acaricides, and insecticides (16); and various types of plant growth regulators (7). Differential patterns for the hazard quotient (HQ) and hazard indices (HI) were observed, of which were above the WHO limits. The decreasing order of the hazard quotient was Cl &gt; Zn &gt; Mg &gt; Cr &gt; Pb for both adults and children. In crux, the quality of water is poor for drinking purposes and the safety and well-being of residents in the recently developed housing societies of the study area may be at risk. Hence, it is important to implement a plan for water quality management, and the regular monitoring (periodic testing of qualitative and quantitative attributes) of the water quality to overcome health-related issues.
Editorial: Sex bias in autoimmunity: From animal models to clinical research and applications (2022)

EDITORIAL article Front. Med., 13 December 2022Sec. Rheumatology Volume 9 - 2022 | https://doi.org/10.3389/fmed.2022.1112966
Microengineered osteoinductive and vasculogenic scaffold (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Opinion mining for social media and news items in Romanian (2013)

Although opinion mining solutions with good performance exist for English, it is much more difficult to develop an effective solution for other languages. Moreover, even in English the results deteriorate strongly if the texts that are processed are from a variety of contexts (domains, sources, etc.) We present the preliminary results of several experiments with a system that uses machine learning in order to identify opinions in a corpus in Romanian that was manually annotated. This dataset contains texts from a wide range of sources: popular social networking sites, blogs, comments, news providers and online forums.
The stage of N-methylation in ergot alkaloid biosynthesis (1979)

Cultures of Claviceps species, strain SD 58, efficiently incorporate N-methyl-4-(γγ-dimethylallyl)-tryptophan (1) as an intact unit into elymoclavine (2), whereas the corresponding tryptamine (3) is not utilized, suggesting N-methylation as the second pathway-specific step in ergot alkloid biosynthesis and rendering pyridoxal phosphate catalysis of C-ring closure unlikely.
Supplemental Figure 2 from &lt;i&gt;NFE2L2&lt;/i&gt; Mutations Enhance Radioresistance in Head and Neck Cancer by Modulating Intratumoral Myeloid Cells (2023)

&lt;p&gt;The relationship between NFE2L2 mutation and radiation resistance in OC cancer. Kaplan-Meier analysis of PFS and OSin OC patients treated with surgery and postoperative (chemo)radiotherapy.&lt;/p&gt;
Neue Anwendung der V.A.C.®-Therapie in der Bauchhöhle bei offenem Abdomen (2004)

Additional intra-abdominally positioned V.A.C. system with an own drainage system supports open abdomen therapy with the standard abdominal V.A.C. system and prevents dissemination of intra-abdominal infection.
Vaccenic Acid Feeding Increases Tissue Levels of Conjugated Linoleic Acid and Suppresses Development of Premalignant Lesions in Rat Mammary Gland (2001)

The objective of this report was to determine whether vaccenic acid (t11-18:1) is converted efficiently to conjugated linoleic acid (c9,t11-18:2, CLA) in rats via the delta 9-desaturase reaction and, if so, whether vaccenic acid could substitute for CLA as an anticancer agent. In Study 1, rats were fed 1%, 2%, or 3% vaccenic acid in their diet, and tissue levels of CLA and CLA metabolites were determined in liver and mammary gland. In general, concentrations of CLA and CLA metabolites increased proportionately with an increase in vaccenic acid intake, at least up to the 2% dose level. Beyond this dose, there was clearly a plateauing effect. Thus vaccenic acid concentration increased from an undetectable level in the control to 78.5 nmol/mg lipid in the liver of rats fed a 2% vaccenic acid diet. This was accompanied by an increase in CLA from 2.3 to 33.6 nmol/mg lipid. These changes were also mirrored in the mammary gland, where increases in vaccenic acid (from 27.5 to 163.2 nmol/mg lipid) and CLA (from 17.8 to 108.9 nmol/mg lipid) were similarly observed. Vaccenic acid at 2% produced a CLA concentration in the mammary gland that was historically associated with a positive response in tumor inhibition based on our past experience. This provided the basis for selecting 2% vaccenic acid in Study 2, which was designed to evaluate its efficacy in blocking the development of premalignant lesions in the rat mammary gland. In this experiment, formation of histologically identifiable pathology due to intraductal proliferation of terminal end bud cells of mammary epithelium was used as the end point of analysis at 6 wk after carcinogen administration. Treatment with vaccenic acid reduced the total number of these premalignant lesions by approximately 50%. We hypothesize that the anticancer response to vaccenic acid is likely to be mediated by its endogenous conversion to CLA via delta 9-desaturase.
Evaluation of adaptive multimicrophone algorithms for hearing aids. (1987)

It appears that one of the most important factors limiting the usefulness of hearing aids is the high sensitivity of hearing aid users to interfering sounds. In this work, the possibility of utilizing computing power that could be packaged into a unit the size of a hearing aid in order to cancel out noises before they reach the ear was investigated. Algorithms for combining the outputs of a number of microphones so as to achieve a considerable noise reduction are proposed and evaluated, and some questions related to implementation are studied. Some experimental results based on numerical and listening tests are presented. The computation is started by indicating to the system a silent period of the main speaker. In order to minimize distortion for the main speaker, the algorithms try to produce an output that matches the first few autocorrelations of the main speaker. It is expected that the system should be able to track sufficiently slow variations in the positions of the noise sources and the main speaker.
Fast and practical head tracking in brain imaging with Time-of-Flight camera (2013)

This paper investigates the potential use of Time-of-Flight cameras (TOF) for motion correction in medical brain scans. TOF cameras have previously been used for tracking purposes, but recent progress in TOF technology has made it relevant for high speed optical tracking in high resolution medical scanners. Particularly in MRI and PET, the newest generation of TOF cameras could become a method of tracking small and large scale patient movement in a fast and user friendly way required in clinical environments. We present a novel methodology for fast tracking from TOF point clouds without the need of expensive triangulation and surface reconstruction. Tracking experiments with a motion controlled head phantom were performed with a translational tracking error below 2mm and a rotational tracking error below 0.5°.