gebhart/patrepeval huggingface dataset:
Theoretical study of torsion potentials in <i>t</i> <i>r</i> <i>a</i> <i>n</i> <i>s</i>-stilbene and substituted <i>t</i> <i>r</i> <i>a</i> <i>n</i> <i>s</i>-stilbenes: Modeling torsions in poly(paraphenylene vinylene) and derivatives (1992)

We present ab initio and semiempirical quantum-chemical calculations as well as simple molecular mechanics calculations on the gas-phase torsion potentials of 1,1′-(trans-1,2-ethenediyl) bisbenzene, commonly known as trans-stilbene, and derivatives of trans-stilbene substituted by methyl or methoxy side groups: 1,1′-(trans-1,2-ethenediyl), bis-2,5-dimethylbenzene, and 1,1′-(trans-1,2-ethenediyl) bis-2,5-dimethoxybenzene. Our results are discussed in light of recent experimental data on poly(paraphenylene vinylene), poly(dimethyl paraphenylene vinylene), and poly(dimethoxy paraphenylene vinylene).
RECOUNT OF REPORTED CASES OF HUMAN FASCIOLIASIS IN BRAZIL OVER THE LAST 60 YEARS (2018)

Fascioliasis is an important anthropozoonotic disease caused by the ubiquitous trematode helminth, Fasciola spp. Here, as elsewhere, it is thought that the disease lacks proper reporting, and the available literature does not reflect unreported cases found in the Brazilian population, or new recently reported cases. The purpose of this work was to perform a recount of human fascioliasis (HF) cases in Brazil. For this, we considered all positive cases published in local and international official Journals, from 1950 to 2016. A theoretical-conceptual research method based on a systematic bibliographic review was applied to identify, select and index articles using the Endnote Basic Software. Here, only 48 cases of HF were found, of which 21 (43.7%) occurred in the South of the country. The small number of reported cases reflects the difficulty in diagnosing HF correctly (clinical and fecal tests). This work provides a real figure of HF reported cases in Brazil and has also corrected inaccurate information found in the literature by conducting a historical survey of the disease. Fasciola hepatica is highly endemic in ruminants and, hypothetically, the number of human cases should also be considerably higher than that reported in the literature. These findings call for more attention in regard to this neglected disease in Brazil.
Identification of Secretory Leukoprotease Inhibitor As an Endogenous Negative Regulator in Allergic Effector Cells (2017)

Mast cells, basophils, and eosinophils are central effectors in allergic inflammatory disorders. These cells secrete abundant serine proteases as well as chemical mediators and cytokines; however, the expression profiles and functions of their endogenous inhibitors remain elusive. We found that murine secretory leukoprotease inhibitor (SLPI) is expressed in basophils and eosinophils but in not in mast cells. SLPI-deficient (<i>Slpi</i><sup>-/-</sup>) basophils produce more cytokines than wild-type mice after IgE stimulation. Although the deletion of SLPI in basophils did not affect the release of chemical mediators upon IgE stimulation, the enzymatic activity of the serine protease tryptase was increased in <i>Slpi</i><sup>-/-</sup> basophils. Mice transferred with <i>Slpi</i><sup>-/-</sup> basophils were highly sensitive to IgE-mediated chronic allergic inflammation. Eosinophils lacking SLPI showed greater interleukin-6 secretion and invasive activity upon lipopolysaccharide stimulation, and the expression of matrix metalloproteinase-9 by these eosinophils was increased without stimulation. The absence of SLPI increases JNK1 phosphorylation at the steady state, and augments the serine phosphorylation of JNK1-downstream ETS transcriptional factor Elk-1 in eosinophils upon stimulation. Of note, SLPI interacts with a scaffold protein, JNK-interacting protein 3 (JIP3), that constitutively binds to the cytoplasmic domain of toll-like receptor (TLR) 4, suggesting that SLPI controls Elk-1 activation <i>via</i> binding to JIP3 in eosinophils. Mice transferred with <i>Slpi</i><sup>-/-</sup> eosinophils showed the exacerbation of chitin-induced allergic inflammation. These findings showed that SLPI is a negative regulator in allergic effector cells and suggested a novel inhibitory role of SLPI in the TLR4 signaling pathways.
Macromol. Chem. Phys. 22/2007 (2007)

Cover: The picture shows schematically the selective transport of butane through the free volume of a PMP/TiO 2 hybrid membrane. The TiO 2 nanoparticles occupy part of the free volume of PMP. This incorporation result in a simultaneous increase of butane permeability and butane/methan selectivity. Further details can be found in the article by W. Yave, S. Shishatskiy, V. Abetz, S. Matson, E. Litvinova, V. Khotimskiy, and K.‐V. Peinemann * on page 2412.
Acridine Orange-Nucleic Acid Fluorescence (1980)

Acridine orange-RNA fluorescence in diagnostic muscle biopsies is a sensitive, specific method to identify single fibers undergoing neurogenic atrophy. Fibers thus identified may be clearly distinguished from nonfluorescent type-specific atrophic fibers, as well as from atrophic fibers encountered in other myopathic conditions. Regenerating fibers, inflammatory cells, and mast cells stain prominently with acridine orange but area easily identified by their morphologic features. Acridine orange-RNA fluorescence is extremely useful in the evaluation of early neurogenic atrophy without fiber-type grouping and may be performed on paraffin-embedded sections, thus allowing retrospective studies. In addition, this technique may provide clues to the pathogenesis of neuromuscular disease that involves altered nucleic acid metabolism.
Optical generation of microwave signal by doped fiber external cavity semiconductor laser for radio-over-fiber transmission (2005)

We report on the first experiments of optical microwave generation by heterodyne beating of two doped-fiber semiconductor external-cavity lasers (DFECL). Our measurements show that minor side-mode beating in DFECL affect the optical heterodyne beat signal. Using the RF methods we study the side-mode suppression in the DFECL.
A Pedestrian Bridge from Transparent Thermoplastics (2002)

Conference paper written by Uwe Gleiter and Johann-Dietrich Woerner presented at IABSE Symposium: Towards a Better Built Environment - Innovation, Sustainability, Information Technology, Melbourne, Australia, 11-13 September 2002.
Mst1 and Mst2 control liver size and suppress the development of hepatocellular carcinoma (2009)

Conrad, Claudius MD, PhD; Zhou, Dawang PhD; Park, Ji Sun MSc; Avruch, Joseph MD; Warshaw, Andrew MD, FACS; Bardeesy, Nabeel PhD Author Information
Biomimetic Sensors: Vectorially Imprinted Hybrid Nanofilm for Acetylcholinesterase Recognition (Adv. Funct. Mater. 32/2015) (2015)

On page 5178, R. E. Gyurcsányi, F. W. Scheller, and co-workers demonstrate specific recognition of acetylcholinesterase, a potential marker of Alzheimer's disease, by a hybrid material which shows threefold selectivity gain by the “shape-specific” electrosynthesized molecularly imprinted polymer, oriented binding to the propidium layer and signal generation exclusively by the enzyme bound to the nanofilm. Acetylcholinesterase is detected in the nanomolar range, whilst interfering proteins are effectively suppressed.
CCDC 1009732: Experimental Crystal Structure Determination (2003)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Five-year clinical effectiveness of a two-step self-etching adhesive. (2007)

The clinical effectiveness of the two-step self-etching adhesive Clearfil SE remained excellent after 5 years of clinical service. Additional etching of the enamel cavity margins resulted in an improved marginal adaptation on the enamel side; however, this was not critical for the overall clinical performance of the restorations.
Abstract 2415: Long-Term Baroreflex Activation Therapy Increases the Threshold for the Induction of Lethal Ventricular Arrhythmias in Dogs with Chronic Advanced Heart Failure (2008)

Heart failure (HF) is associated with a high incidence of ventricular tachycardia (VT) and fibrillation (VF). Patients with HF in whom these lethal arrhythmias can be induced by electrophysiological (EP) testing carry a high risk of sudden cardiac death. We showed that chronic electrical carotid baroreflex activation therapy (BAT) with the Rheos® System (CVRx, Inc.) improves LV function, attenuates LV remodeling and restores autonomic sympathetic-parasympathetic balance in dogs with HF. This study examined the effects of long-term therapy with BAT on the induction of VT or VF in dogs with coronary microembolization-induced HF (LV ejection fraction ~20%). Eleven dogs with HF underwent EP testing at baseline prior to therapy and after 3 and 6 months of therapy with BAT and again 6 weeks after withdrawal of BAT therapy (n = 7) or no therapy at all (Control, n = 4). Programmed ventricular stimulation was performed from the right ventricular apex and included delivery of up to 4 extrastimuli at progressively shorter coupling intervals (in steps of 10 msec). The extrastimuli were delivered following 8 ventricular paced beats with a drive cycle length between 600 and 200 msec. If a sustained monomorphic VT or VF could not be induced, isoproterenol infusion was initiated to increase the sinus rate by ~30% and the EP stimulation protocol was repeated. At baseline, a sustained VT or VF was induced in all 11 dogs (100%). After 3 and 6 months of follow-up, all Control dogs (100%) were induced into sustained VT or VF. After 3 months of BAT, only 3 of 7 dogs (43%) were induced into sustained VT or VF. After 6 months of BAT, only 2 of 7 dogs (29%) were induced into sustained VT or VF. Finally after withdrawal of BAT therapy, all dogs (100%) were again induced into systained VT or VF. In addition to improving LV function and attenuating LV remodeling, long-term monotherapy with BAT markedly increases the threshold for lethal ventricular arrhythmias in dogs with chronic HF. This is a marked improvement over inducibility of lethal arrhythmias seen in historical untreated controls. This benefit of BAT supports the continued exploration of this device as a therapeutic modality for treating patients with chronic HF and increased risk of sudden cardiac death.
Cytotoxic T-cell and NK-cell Lymphomas (2014)

The cytotoxic T-cell and natural killer (NK)-cell lymphomas and related disorders are important but relatively rare lymphoid neoplasms that frequently are a challenge for practicing pathologists. This selective review, based on a meeting of the International Lymphoma Study Group, briefly reviews T-cell and NK-cell development and addresses questions related to the importance of precise cell lineage (αβ-type T cell, γδ T cell, or NK cell), the implications of Epstein-Barr virus infection, the significance of anatomic location including nodal disease, and the question of further categorization of enteropathy-associated T-cell lymphomas. Finally, developments subsequent to the 2008 World Health Organization Classification, including the recognition of indolent NK-cell and T-cell disorders of the gastrointestinal tract are presented.
Platinum‐Catalyzed Amidocarbonylation. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
&lt;title&gt;Model-based superresolution CSO processing&lt;/title&gt; (1993)

This is a description of a model-based maximum likelihood estimation technique for determining the position and intensities of closely spaced objects (CSO's) present in the focal plane of a forward-looking infrared (FLIR) sensor. The object model considered here is approximate point sources; we present a methodology to superresolve two point sources separated closer than the Rayleigh resolution criteria. The Cramer-Rao theoretical lower bound is derived in closed form; the variance of the proposed estimator will be compared to this bound to verify its superresolving capability. Simulation results are presented for medium and high signal-to-noise (Gaussian noise) ratios and source separations.
Conception, synthèse et évaluation d'une nouvelle famille d'agents de fluoration électrophile énantiosélective issue des alcaloides du Quinquina (2002)

Ce travail focalise sur l'obtention de composes carbonyles a-fluores enantiomeriquement enrichis par fluoration electrophile enantioselective. D'abord, nous avons concu et synthetise une nouvelle famille d'agents de fluoration electrophile enantioselective derives des alcaloides du quinquina. Leur synthese rapide et efficace permet de les obtenir sous forme d'ammoniums quaternaires N-fluores avec de bons rendements par reaction de transfluoration. Cette synthese mise au point, nous avons tire profit de la structure polyfonctionnelle des alcaloides pour synthetiser de nombreux derives afin d'avoir une large panoplie de structures. Ces nouveaux agents de fluoration ont ete engages dans la fluoration d'enolates et d'enoxysilanes. Le produits fluores correspondants ont ete obtenus avec des rendements quantitatifs et des enantioselections interessantes. En effet, on a pu decouvrir que la chimie des enolates donnaient des enantioselections moyennes de l'ordre de 50 %, alors que les enoxysilanes ont permis d'obtenir les a-fluoro-cetones desirees avec de hautes enantioselections (jusqu'a 87 %. Puis, grâce aux differents substrats etudies sous forme d'enolates ou d'enoxysilanes, et grâce aux differents agents de fluoration synthetises, nous avons realise une etude Relation Structure-Enantioselectivite. Ainsi on a elabore un modele de reconnaissance moleculaire et pu comprendre les enantioselections observees pour les substrats etudies. Enfin notre travail a consiste en l'application de notre methodologie a la synthese d'une molecule fluoree d'interet therapeutique. Apres la synthese de l'intermediaire clef desire, nos agents de fluoration ont servi pour la fluoration electrophile enantioselective tardive de cet intermediaire. La molecule fluoree a ainsi ete obtenue avec un exces enantiomerique de 76 %.
Supplementary Figure S4 from Small-Molecule Polθ Inhibitors Provide Safe and Effective Tumor Radiosensitization in Preclinical Models (2023)

&lt;p&gt;Accompanies Figure 3 (Effect of ART558 under hypoxic conditions)&lt;/p&gt;
Higher order absorbing boundary conditions for the finite-difference time-domain method (1992)

Higher-order absorbing boundary conditions are introduced and implemented in a finite-difference time-domain (FDTD) computer code. Reflections caused by the absorbing boundary conditions are examined. For the case of a point source radiating in a finite computational domain, it is shown that the error decreases as the order of approximation of the absorbing boundary condition increases. Fifth-order approximation reduces the normalized reflections to less than 0.2%, whereas the widely used second-order approximation produces about 3% reflections. A method for easy implementation of any order approximation is also presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Zeros of random tropical polynomials, random polygons and stick-breaking (2016)

For $i = 0, 1, \ldots , n$, let $C_i$ be independent and identically distributed random variables with distribution $F$ with support $(0,\infty )$. The number of zeros of the random tropical polynomials $\mathcal {T}f_n(x) = \min _{i=1,\ldots ,n}(C_i + ix)$ is also the number of faces of the lower convex hull of the $n+1$ random points $(i,C_i)$ in $\mathbb {R}^2$. We show that this number, $Z_n$, satisfies a central limit theorem when $F$ has polynomial decay near $0$. Specifically, if $F$ near $0$ behaves like a $gamma(a,1)$ distribution for some $a > 0$, then $Z_n$ has the same asymptotics as the number of renewals on the interval $[0,\log (n)/a]$ of a renewal process with inter-arrival distribution $-\log (Beta(a,2))$. Our proof draws on connections between random partitions, renewal theory and random polytopes. In particular, we obtain generalizations and simple proofs of the central limit theorem for the number of vertices of the convex hull of $n$ uniform random points in a square. Our work leads to many open problems in stochastic tropical geometry, the study of functionals and intersections of random tropical varieties.
The inverse emulsion polymerization of acrylamide with pentaerythritolmyristate as emulsifier. 1. Experimental studies (1998)

The inverse emulsion polymerization of aqueous acrylamide solutions in isooctane as dispersing media with the emulsifier pentaerythritolmyristate and an oil-soluble azo initiator was studied, particularly with respect to the influence of the chemically pure emulsifier. In this free radical polymerization, a water-in-oil emulsion with droplet sizes around 10μm is converted into a latex with average particle diameters between 80 and 200nm containing a polymer with molar masses up to 16×106gmol-1 Kinetic data were measured by adiabatic as well as by isothermal calorimetry. The influences of various parameters on polymerization kinetics, particle numbers and molar mass averages were studied. Experimental results show a positive influence of the emulsifier concentration on the reaction rate and indicate the dominance of a bimolecular termination re-action with respect to the polymer radicals above a certain initiator concentration. © 1998 SCI.
High power solid state switch module (2004)

A high voltage, high di/dt, solid state switch module has been developed. This compact module can be used to replace thyratrons in high power modular applications. The module contains multiple silicon thyristors packaged in a low inductance series configuration with a strip-line output connection. A self powered gate drive is triggered by a 15 V, 1 A pulse. Each module has a rating of 8000 volts and is capable of conducting 6000 amperes over a 10 microsecond pulse with maximum repetition rates of over 120 hertz. The modules have demonstrated a 70 ns turn-on delay time and operation at 25 kA/us, limited by the external circuit. Switches rated for over 50 kV have been assembled using a modular design to easily connect the modules in series. These modules are suitable for pulse modulators for high power RF and microwave amplifiers used in particle accelerators, radars, medical and defense applications, medium and high power lasers, pulsed magnet drivers, and other high power applications. The performance of the modules under normal and fault conditions is described.
Microfluidic Synthesis of Polymer and Inorganic Particulate Materials (2010)

This article reviews recent developments in the microfluidic preparation of different types of particles made of polymeric and inorganic materials. We discuss control of the particle sizes, morphologies, shapes, and structures in terms of various features of microfluidic synthesis.
Nutrient loading of developing seeds (2007)

Interest in nutrient loading of seeds is fuelled by its central importance to plant reproductive success and human nutrition. Rates of nutrient loading, imported through the phloem, are regulated by transport and transfer processes located in sources (leaves, stems, reproductive structures), phloem pathway and seed sinks. During the early phases of seed development, most control is likely to be imposed by a low conductive pathway of differentiating phloem cells serving developing seeds. Following the onset of storage product accumulation by seeds, and, depending on nutrient species, dominance of path control gives way to regulation by processes located in sources (nitrogen, sulfur, minor minerals), phloem path (transition elements) or seed sinks (sugars and major mineral elements, such as potassium). Nutrients and accompanying water are imported into maternal seed tissues and unloaded from the conducting sieve elements into an extensive post-phloem symplasmic domain. Nutrients are released from this symplasmic domain into the seed apoplasm by poorly understood membrane transport mechanisms. As seed development progresses, increasing volumes of imported phloem water are recycled back to the parent plant by process(es) yet to be discovered. However, aquaporins concentrated in vascular and surrounding parenchyma cells of legume seed coats could provide a gated pathway of water movement in these tissues. Filial cells, abutting the maternal tissues, take up nutrients from the seed apoplasm by membrane proteins that include sucrose and amino acid/H<sup>+</sup> symporters functioning in parallel with non-selective cation channels. Filial demand for nutrients, that comprise the major osmotic species, is integrated with their release and phloem import by a turgor-homeostat mechanism located in maternal seed tissues. It is speculated that turgors of maternal unloading cells are sensed by the cytoskeleton and transduced by calcium signalling cascades.
A +1 ribosomal frameshifting motif prevalent among plant amalgaviruses (2016)

Sequence accessions attributable to novel plant amalgaviruses have been found in the Transcriptome Shotgun Assembly database. Sixteen accessions, derived from 12 different plant species, appear to encompass the complete protein-coding regions of the proposed amalgaviruses, which would substantially expand the size of genus Amalgavirus from 4 current species. Other findings include evidence for UUU_CGN as a 1 ribosomal frameshifting motif prevalent among plant amalgaviruses; for a variant version of this motif found thus far in only two amalgaviruses from solanaceous plants; for a region of helical coiled coil propensity conserved in a central region of the ORF1 translation product of plant amalgaviruses; and for conserved sequences in a C-terminal region of the ORF2 translation product (RNA-dependent RNA polymerase) of plant amalgaviruses, seemingly beyond the region of conserved polymerase motifs. These results additionally illustrate the value of mining the TSA database and others for novel viral sequences for comparative analyses.
Ca <sup>2+</sup> /Calmodulin Dependent Protein Kinase Kinase-2 (CaMKK2) promotes Protein Kinase G (PKG)-dependent actin cytoskeletal assembly to increase tumor metastasis (2023)

Triple-negative breast cancers (TNBCs) tend to become highly invasive early during cancer development. Despite some successes in the initial treatment of patients diagnosed with early-stage localized TNBC, the rate of metastatic recurrence remains high with poor long-term survival outcomes. Here we show that elevated expression of the serine/threonine-kinase, Calcium/Calmodulin (CaM)-dependent protein kinase kinase-2 (CaMKK2), is highly correlated with tumor invasiveness. We determined that genetic disruption of CaMKK2 expression, or inhibition of its activity, disrupted spontaneous metastatic outgrowth from primary tumors in murine xenograft models of TNBC. High-grade serous ovarian cancer (HGSOC), a high-risk, poor-prognosis ovarian cancer subtype, shares many genetic features with TNBC, and importantly, CaMKK2 inhibition effectively blocked metastatic progression in a validated xenograft model of this disease. Probing the mechanistic links between CaMKK2 and metastasis we defined the elements of a new signaling pathway that impacts actin cytoskeletal dynamics in a manner which increases cell migration/invasion and metastasis. Notably, CaMKK2 increases the expression of the phosphodiesterase PDE1A which decreases the cGMP-dependent activity of protein kinase G1 (PKG1). This inhibition of PKG1 results in decreased phosphorylation of Vasodilator-Stimulated Phosphoprotein (VASP), which in its hypophosphorylated state binds to and regulates F-actin assembly to facilitate contraction/cell movement. Together, these data establish a targetable CaMKK2-PDE1A-PKG1-VASP signaling pathway that controls cancer cell motility and metastasis. Further, it credentials CaMKK2 as a therapeutic target that can be exploited in the discovery of agents for use in the neoadjuvant/adjuvant setting to restrict tumor invasiveness in patients diagnosed with early-stage TNBC or localized HGSOC.