gebhart/patrepeval huggingface dataset:
Effect of age on the expressed B cell repertoire: role of B cell subsets (1993)

Aged humans and experimental animals are impaired in their responses to most foreign antigens although they produce greater amounts of autoantibodies. We have examined the effect of age on the production of antibodies to a prototypic foreign antigen, sheep erythrocytes (SRBC), and to a prototypic autoantigen, bromelain-treated mouse erythrocytes (BrMRBC), in young and old mice before and after immunization with SRBC. Old mice express more anti-BrMRBC plaque-forming cell (PFC) antibodies before and an even greater number after immunization with SRBC than young mice. Conversely, old mice produce far fewer anti-SRBC PFC than young mice following immunization with SRBC. We hypothesized that the differences in the responses of old mice to BrMRBC and SRBC reflects differences in the activity of CD5+ and CD5- B cells. To test this hypothesis we immunized young and old mice with foreign antigens reported (and confirmed in our studies) to stimulate CD5+ B cells [TNP-ficoll and phosphorylcholine-keyhole limpet hemocyanin (KLH)] or CD5- B cells (SRBC and TNP-KLH). We found that the PFC response of old mice to antigens mediated by CD5+ B cells was equal to or greater than that of young mice. In contrast the PFC response of old mice induced by antigens mediated by CD5- B cells was only 10% that of young mice. Thus it appears that the immune response of old mice is well maintained for antigens which elicit a CD5+ B cell response but not for those which elicit a CD5- B cell response.(ABSTRACT TRUNCATED AT 250 WORDS)
Functional profiles of coronal and dentin caries in children (2018)

<b>Background</b>: Dental caries results from a dysbiosis of tooth-associated biofilms and frequently extends through enamel into dentin which has a different structure and composition. <b>Objective</b>: To evaluate the metatranscriptome of caries to determine the metabolic potential of caries communities compared with health. <b>Design</b>: Samples from children, caries-free (CF: <i>n</i> = 4) or with coronal (CC: <i>n</i> = 5) or dentin (DC: <i>n</i> = 5) caries were examined for gene expression potential. Functional profiling was performed using HUMAnN2 (HMP Unified Metabolic Analysis Network). <b>Results</b>: There was increased gene expression diversity in DC compared with CC and CF. Genes in CF included alcohol dehydrogenase from <i>Neisseria sicca</i>, methylenetetrahydrofolate reductase from <i>Streptococcus sanguinis</i> and choline kinase from streptococci. Genes in CC mapped mainly to <i>Streptococcus mutans</i>. Arginine deiminase in DC mapped to <i>S. sanguinis</i> and <i>Actinomyces naeslundii</i>. Glycerol kinase genes mapped to <i>S. sanguinis</i> in all groups whereas glycerol kinase in DC were from <i>Rothia, Prevotella</i> and streptococci. Uracil-DNA glycosylase in DC mapped to <i>Prevotella denticola</i> and <i>Actinomyces</i>. Repressor LexA in DC mapped to <i>Scardovia wiggsiae, Dialister invisus</i> and <i>Veillonella parvula</i>. <b>Conclusions</b>: Functional profiling revealed enzyme activities in both caries and caries-free communities and clarified marked differences between coronal and dentin caries in bacterial composition and potential gene expression.
Advanced mimetic materials for meniscus tissue engineering : targeting segmental vascularization (2012)

Meniscus lesions are among the most common orthopaedic injuries which can ultimately lead to degeneration of the knee articular cartilage. The human meniscus has a limited healing potential, partly due to a poor vasculature, and thus meniscus regeneration using tissue engineering strategies has recently been investigated as a promising alternative to total/partial meniscectomy [1]. Advanced scaffolds for tissue engineering of meniscus should be able to mimic and preserve the asymmetric vascular network of this complex tissue, i.e. enable controlling the segmental vascularization during the regeneration process. Novel scaffolds were produced combining a silk polymeric matrix (12 wt%) [2] and the methacrylated gellan gum hydrogel (iGG-MA), which has been shown to be able to prevent the ingrowth of endothelial cells and blood vessels into the hydrogels [3,4]. The angiogenic/ anti-angiogenic potential of acellular and cell-laden silk-12 scaffolds combined with iGG-MA hydrogel was investigated in vivo, using the chick embryo chorioallantoic membrane (CAM) assay. For producing the cell-laden scaffolds, human meniscus cells (HMC¢s) were isolated from morphologically intact human menisci using an enzymatic-based digestion and expanded using standard culture conditions. The HMC’sladen hydrogel/silk scaffolds were produced by encapsulating the HMC’s into a 2 wt% GG-MA hydrogel, followed by impregnation onto the 12 wt% silk scaffold and ionic-crosslinking in a saline solution. A CAM assay was used to investigate the control of segmental vascularization of the acellular and HMC¢s-laden hydrogel/silk scaffolds by the effect of GG-MA hydrogel, until day 14 of embryonic development. The in vivo study allowed investigating the number of macroscopic blood vessels converging to the implants. The evaluation of possible inflammation and endothelial cells ingrowths was performed by histological (haematoxylin and eosin - H&E - staining) and immunohistochemical methods (SNA-lectin staining). When the silk-12 scaffold was combined with the hydrogel, an inhibitory effect was observed as demonstrated by the low number of convergent blood vessels. Results have shown that iGG-MA hydrogel prevented the endothelial cells adhesion and blood vessels infiltration into the HMC’s hydrogel/silk scaffolds, after 4 days of implantation. This study showed that the hydrogel/silk scaffolds enabled controlling the segmental vascularization, thus it can possibly mimic the native vasculature architecture during meniscus regeneration.
Anti-E Alloimmunization: A Rare Cause of Severe Fetal Hemolytic Disease Resulting in Pregnancy Loss (2009)

We report a case of severe intrauterine hemolysis caused by sole anti-E alloimmunization. A 36-year-old multipara woman presented with hydrops fetalis at 27 weeks of gestation. She had a history of previous neonatal death. In this pregnancy, she was found to have very high titer of anti-E antibody. Ultrasonography detected marked skin edema, cardiomegaly, hepatosplenomegaly, pleural effusion, ascites, placentomegaly, and polyhydramnios. The Doppler peak systolic velocity in the middle cerebral artery was 0.8 m/s, indicating severe fetal anemia. Multiple intrauterine transfusions for the anemic fetus were administered. However, persistent severe fetal anemia and placentomegaly caused poor neonatal death and mirror syndrome in the mother. Uncommon red blood cell alloimmunization has to be watched for early in any population, especially in a woman with a history of unexplained perinatal loss.
Studying and improving the performance of ETSI ITS contention-based forwarding (CBF) in urban and highway scenarios: S-FoT+ (2023)

This paper evaluates the performance of ETSI ITS Contention-Based Forwarding (CBF) and ETSI Simple GeoBroadcast forwarding while disseminating warning messages over a Geographical Area in highway and urban scenarios. Our experimental evaluation considers the complete ETSI ITS architecture including the Decentralized Congestion Control (DCC) mechanism. We propose an enhanced CBF mechanism, named S-FOT+, which combines several improvements to the ETSI CBF algorithm. S-FoT+ has a similar or better performance than the ETSI forwarding algorithms regarding both reliability and end-to-end delay while requiring much fewer transmissions. The improvements are equally effective and efficient in both urban and highway scenarios with large Destination Areas. Finally, we evaluate the trade-offs that stem from using multi-hop broadcast mechanisms in urban settings with smaller Destination Areas when compared to single-hop broadcast. Results show that multi-hop mechanisms significantly improve coverage at the cost of an increased number of transmissions.
Contributions to early HIV diagnosis among patients linked to care vary by testing venue (2008)

Test venues varied by the number of new diagnoses made and the stage of illness at diagnosis. To improve the rate of early diagnosis, scarce resources should be allocated to maximize the number of new diagnoses at screening venues where diagnoses are more likely to be early or alter testing strategies at test venues where diagnoses are traditionally made late. Efforts to improve early diagnosis should be coordinated longitudinally on a regional basis according to this conceptual paradigm.
Pervaporation of Alcohols and Methyl <i>t</i><i>ert</i>-Butyl Ether through a Dense Poly(2,6-dimethyl-1,4-phenylene oxide) Membrane (2004)

Pervaporation separation and swelling experiments of methanol/methyl tert-butyl ether mixtures were performed by using a flat-sheet, dense poly(2,6-dimethyl-1,4-phenylene oxide) membrane prepared from a chloroform casting solvent. The effect of the feed composition on the membrane performance was described by the permeability of the components, the separation factor, and the sorption selectivity. The effect of the feed temperature on the separation was also studied, and the Arrhenius activation energy for permeability was determined over the whole range of feed composition. Pervaporation operations offered a maximum methanol selectivity of 5.4 and an overall normalized flux of 110 kg·μm/m2·h. Pervaporation and sorption experiments were also conducted using ethanol, propanol, butanol, and octanol to study the effect of the size of the alcohol molecule on the transport across the membrane.
Feature analysis and centromere segmentation of human chromosome images using an iterative fuzzy algorithm (2002)

Classification of homologous chromosomes is essential to advanced studies of cancer genetics. Centromere intensities are believed to be an important differentiating feature between homologs. Therefore, segmentation of centromeres is a major step toward the realization of homolog classification. This paper describes an iterative fuzzy algorithm which successfully segments centromeres from images of human chromosomes prepared using fluorescence in-situ hybridization technique. The algorithm is based on assigning a fuzzy membership value to each pixel in the centromere image. An iterative algorithm then updates and minimizes a defined error function. Chromosome 22, a highly heteromorphic chromosome, is used to verify the centromere segmentation method. Homologs of this chromosome are classified based on their segmented centromere intensities as well as their morphological differences. The classification results of these two methods agree completely and are used to validate our developed algorithm.
Development of the Astro Edge solar array (2002)

The Astro Edge solar array is a new and innovative low concentrator power generating system which has been selected for CTA Incorporated's NASA Small Spacecraft Technology Initiative (SSTI) program. Under the program, Astro will design, develop, produce and qualify two Right Astro Edge wings to support a July 1996 launch of the SSTI SmallSat dubbed "CLARK". The Astro Edge was selected as a new technology to benefit future NASA and commercial missions by providing high specific power, high stiffness, low risk, low stowed volume, reliability, light weight, and cost reduction features to meet the agency's "better, faster, cheaper" goals. A brief program overview of design requirements, configuration, subsystem description, analysis, and planned testing of the SSTI Astro Edge solar array is discussed.
Neutral Bimetallic Nickel(II) Phenoxyiminato Catalysts for Highly Branched Polyethylenes and Ethylene−Norbornene Copolymerizations (2008)

The synthesis and characterization of novel bimetallic, neutrally charged dinickel 2,7-diimino-1,8-dioxynaphthalene polymerization catalysts is reported. Ethylene polymerizations as well as ethylene-co-norbornene copolymerizations display increased catalytic activity, methyl branch formation, and comonomer enchainment selectivity versus the monometallic analogues. Furthermore, these systems turn over in the absence of cocatalyst under mild conditions.
&lt;title&gt;The Hologram As An Electronic Display&lt;/title&gt; (1983)

Displays have only one function: the conveying of information to human beings. To do this well, the display must be well suited to the human viewing-comprehending system. Evolving in a three-dimensional (3D) world, humans have an exquisitely tuned system for seeing in 3D. A display capable of providing information in 3D would have a significant advantages over its more common 2D competitors: television, the printed page, etc. The fact that 3D displays are not in common use can only mean that the existing 3D displays have major drawbacks. Indeed that is the case.
Host‐Guest Chemistry of Linked β‐ and γ‐Cyclodextrin Dimers and 1‐ and 2‐Naphthyl‐Sulfonamide Substituted Poly(acrylate)s in Aqueous Solution (2017)

Abstract Host‐guest complexation by β‐ and γ‐cyclodextrin and their four succinamide‐linked dimers of the naphthyl substituents of four randomly substituted poly(acrylate)s in twenty‐four aqueous systems has been characterised. Complexation occurs through entry of the naphthyl substituents into the cyclodextrin annuli. The naphthyl substitution position, the length of the tether attaching the naphthyl substituent to the poly(acrylate) backbone and the size and stereochemistry of the cyclodextrin hosts determine the relative stabilities of poly(acrylate) intra‐strand complexes in dilute solution and the formation of inter‐strand cross‐links in more concentrated solution.
REAL-TIME SIMULATION OF HAPTIC COLLISION BETWEEN NONLINEAR SOLIDS (2015)

In this work a novel strategy for the real-time simulation of collision between non-linear deformable solids is presented. We use a PGD technology to generate computational vademecums or metamodels with the response solution, and employ the Voxmap Pointshell method for two deformable solids obtaining the response of the system for haptic feedback rates. These are in essence a pre-computed solution of a parametric model in which every possible situation during the on-line phase of the method has been considered through the
Preclinical evaluation of non-imidazole histamine H3 receptor antagonists in comparison to atypical antipsychotics for the treatment of cognitive deficits associated with schizophrenia (2012)

Cognitive deficits associated with schizophrenia (CDS) are implicated as a core symptom cluster of the disease and are associated with poor daily life functioning. Unfortunately, current antipsychotic agents provide little alleviation of CDS, representing a critical unmet therapeutic need. Here we investigated the effects of ABT-239 and A-431404, non-imidazole histamine H(3) receptor (H(3)R) antagonists, in animal models with relevance to CDS. As N-methyl-d-aspartate receptor hypofunction is considered an important factor in the pathogenesis of schizophrenia, acute administration of ketamine or MK-801 was used to induce cognitive impairments. The assays employed in the current studies were spontaneous alternation in cross-maze, used as an indication of working memory, and inhibitory avoidance (IA), used to assess long-term memory retention. Risperidone and olanzapine were also tested to directly compare the effects of H(3)R antagonists to two widely used antipsychotics. ABT-239 and A-431404, but not risperidone and olanzapine, attenuated ketamine-induced deficits on spontaneous alternation in cross-maze, while none of these compounds affected alternation performance on their own. ABT-239 and A-431404 also attenuated MK-801-induced impairments in IA; no effects were observed when given alone. Risperidone and olanzapine, however, failed to attenuate MK-801-induced deficits in IA and produced dose-dependent impairments when given alone. ABT-239 was also investigated in methylazoxymethanol acetate (MAM) treated rats, a neurodevelopmental model for schizophrenia. Chronic, but not acute, treatment with ABT-239 significantly improved spontaneous alternation impairments in MAM rats tested in cross-maze. In summary, these results suggest H(3)R antagonists may have the potential to ameliorate CDS.
The clinical impact of <scp>COVID</scp>‐19 on endoscopic surgery in Japan: Analysis of data from the National Clinical Database (2023)

The number of endoscopic surgeries decreased in 2020 as a result of the COVID-19 pandemic. However, the procedures were performed safely in Japan.
Unobtrusive monitoring of ECG-derived features during daily smartphone use (2014)

Heart rate variability (HRV) is known to be one of the representative ECG-derived features that are useful for diverse pervasive healthcare applications. The advancement in daily physiological monitoring technology is enabling monitoring of HRV in people's everyday lives. In this study, we evaluate the feasibility of measuring ECG-derived features such as HRV, only using the smartphone-integrated ECG sensors system named Sinabro. We conducted the evaluation with 13 subjects in five predetermined smartphone use cases. The result shows the potential that the smartphone-based sensing system can support daily monitoring of ECG-derived features; The average errors of HRV over all participants ranged from 1.65% to 5.83% (SD: 2.54~10.87) for five use cases. Also, all of individual HRV parameters showed less than 5% of average errors for the three reliable cases.
Ionic end-capping of (semi)telechelic polymers by mesogens (2000)

Two methods have been used to end-cap linear polymer chains at one end or at both ends by a mesogen through ionic bonding. These polymers are designated as liquid-crystalline halato(semi)telechelic polymers (LC H(S)TPs). The first method relies on the ion exchange reaction between the metal counterion of halato(semi)telechelic polymers and an ionic mesogen. The second method is based on the proton transfer from a sulfonic or carboxylic acid end-group to a tertiary aliphatic amine, this approach being controlled by the relative pKa values of the acidic and basic groups. If the pKa difference is not large enough, strong hydrogen-bonding is observed by Fourier-transform infrared (FTIR) spectroscopy rather than proton transfer. The resulting materials have been characterized by differential scanning calorimetry (DSC), polarized optical microscopy (POM) and small-angle X-ray scattering (SAXS). © 2000 Society of Chemical Industry
Delayed venous occlusion following embolotherapy of vascular malformations in the brain. (1992)

It is postulated that thrombosis in the arteriovenous fistula group was induced by conversion (due to embolization) of a patulous high flow venous outlet into a slow flow system; in the vein-of-Galen group, the occlusion was thought to be due to high-flow venopathy.
A Distributed CSMA Algorithm for Throughput and Utility Maximization in Wireless Networks (2009)

In multihop wireless networks, designing distributed scheduling algorithms to achieve the maximal throughput is a challenging problem because of the complex interference constraints among different links. Traditional maximal-weight scheduling (MWS), although throughput-optimal, is difficult to implement in distributed networks. On the other hand, a distributed greedy protocol similar to IEEE 802.11 does not guarantee the maximal throughput. In this paper, we introduce an adaptive carrier sense multiple access (CSMA) scheduling algorithm that can achieve the maximal throughput distributively. Some of the major advantages of the algorithm are that it applies to a very general interference model and that it is simple, distributed, and asynchronous. Furthermore, the algorithm is combined with congestion control to achieve the optimal utility and fairness of competing flows. Simulations verify the effectiveness of the algorithm. Also, the adaptive CSMA scheduling is a modular MAC-layer algorithm that can be combined with various protocols in the transport layer and network layer. Finally, the paper explores some implementation issues in the setting of 802.11 networks.
Sirolimus-Eluting Stents for In-Stent Restenosis? (2003)

In-stent restenosis (ISR) is the most common reason for failure of percutaneous coronary intervention. When balloon angioplasty is used for ISR,
Cetyl alcohol mediated synthesis of CuCr<sub>2</sub>O<sub>4</sub> spinel nanoparticles: a green catalyst for selective oxidation of aromatic C–H bonds with hydrogen peroxide (2014)

We report here cetyl alcohol-promoted synthesis of spherical CuCr<sub>2</sub>O<sub>4</sub> spinel nanoparticles with almost uniform morphology, prepared hydrothermally.
Pricing in WiMAX Networks (2009)

This chapter contains sections titled: Introduction Economics in Network Engineering Building the Pricing Schemes Pricing in Different WiMAX Topologies Conclusion References
Radial excitation force generated by permanent magnet motor using d-axis current injection (2018)

This paper proposes a dynamic characteristics measurement method for condition monitoring in a rotor system with a permanent magnet (PM) motor. The PM motor is used not only as a torque generator but also as an exciter for measuring the dynamic characteristics of the rotor system. The radial excitation force is generated by current injection into the d-axis motor windings under eccentricity. The principle of the radial excitation force generation is theoretically discussed in this paper. Furthermore, the force is numerically calculated and experimentally measured to verify the proposed excitation method. It becomes clear that the radial force from the motor windings is proportional to the d-axis current and eccentricity. Thus, the force can be used to measure the frequency response functions of rotor systems as a stability index under eccentricities such as unbalanced vibration.
Three-dimensional comparison of peripheral benzodiazepine binding and histological findings in rat brain tumor (1990)

Experiments were undertaken to determine the in vivo utility of the mixed benzodiazepine ligand [3H]flunitrazepam and the selective peripheral benzodiazepine ligand [3H]PK 11195 [1-(2-chlorophenyl)-N-methyl-N-(1-methylpropyl)-3-isoquinoline carboxamide] to outline the borders of rat C6 glial tumors in three dimensions. Intravenous injection of [3H]flunitrazepam resulted in a tumor/cortex ratio of radioactive densities between 2.7 and 1.5 within the first 60 minutes after injection. [3H]PK 11195 demonstrated a higher tumor/cortex ratio (5.3) than [3H]flunitrazepam. For three-dimensional studies, images were generated from thionin-stained histological sections and autoradiograms. The mixed type benzodiazepine ligand [3H]flunitrazepam was superior in showing some of the normal anatomical structures surrounding the tumor, whereas [3H]PK 11195, a specific peripheral ligand, demonstrated higher tumor/brain contrast and superior topographical correlation between histological and autoradiographic images. Implications of peripheral benzodiazepine receptor ligands for positron emission tomography are discussed.