gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis and Antiinflammatory Activity of 1‐(6′‐Substituted‐2′‐benzothiazolyl)‐3,4‐dimethylpyrano[2,3‐c]pyrazol‐6(1H)‐ones. (1986)

Abstract The title compounds (IV) can be synthesized by the two pathways shown in the scheme.
Increased Production of Soluble FAS in Acute Liver Failure (1998)

Conference Abstract| February 01 1998 Increased Production of Soluble FAS in Acute Liver Failure A Tagami; A Tagami 1Institute of Liver Studies, King's College School of Medicine and Dentistry, London SE5 9RS Search for other works by this author on: This Site PubMed Google Scholar H Ohnishi; H Ohnishi 1Institute of Liver Studies, King's College School of Medicine and Dentistry, London SE5 9RS Search for other works by this author on: This Site PubMed Google Scholar RD Hughes RD Hughes 1Institute of Liver Studies, King's College School of Medicine and Dentistry, London SE5 9RS Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1998) 94 (s38): 14P. https://doi.org/10.1042/cs094014Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation A Tagami, H Ohnishi, RD Hughes; Increased Production of Soluble FAS in Acute Liver Failure. Clin Sci (Lond) 1 February 1998; 94 (s38): 14P. doi: https://doi.org/10.1042/cs094014Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1998 The Biochemical Society and the Medical Research Society1998 Article PDF first page preview Close Modal You do not currently have access to this content.
Parenteral and enteral feeding in preterm piglets differently affects extracellular matrix proteins, enterocyte proliferation and apoptosis in the small intestine (2010)

The preterm intestine is immature and responds differently to total parenteral nutrition (TPN) and enteral nutrition, compared with the term intestine. We hypothesised that in preterms, diet composition and feeding route affect mucosal morphology, enterocyte mitosis and apoptosis, and the distribution of laminin-1, fibronectin and collagen IV (extracellular matrix proteins (ECMP)). Preterm piglets (93.5 % of gestation) were delivered via caesarean section and birth weight-matched allocated to one of the four experimental groups: the piglets were either euthanised immediately after delivery, after 3 d of TPN or after 2 d enteral feeding with colostrum or milk formula, following 3 d of TPN. We combined immunohistochemistry, image analysis and stereological measurements to describe the intestinal mucosal layer. No significant changes occurred after 3 d of TPN. Feeding colostrum or milk replacer for 2 d after TPN was associated with an increased crypt depth. Only enteral feeding with colostrum resulted in an increased villus height and mitotic index. Neither TPN nor enteral feeding changed the distribution pattern of ECMP or the occurrence of bifid crypts. The immature distribution pattern of ECMP in TPN-fed piglets, coupled with unchanged enterocyte mitosis and apoptosis indices, illustrates that feeding preterm pigs 3 d TPN does not lead to mucosal atrophy. Despite the invariable distribution of ECMP, colostrum was associated with crypt hyperplasia resulting in an increased villus height. These data illustrate that some mechanisms regulating cell turnover are immature in preterms and may in part explain the abnormal gut responses to TPN and enteral feeding in prematurely born pigs.
Association of FOXP4 Gene with Prostate Cancer and the Cumulative Effects of rs4714476 and 8q24 in Chinese Men (2015)

These data suggest that rs4714476 at the 5' near gene of FOXP4 potentially contributes to the susceptibility of PCa in Chinese men. The cumulative effect of rs4714476 at FOXP4 and 8q24 could increase PCa risk.
A Nucleophilic Chemical Probe Targeting Electrophilic Functional Groups in an Untargeted Way to Explore Cysteine Modulators in Natural Products (2022)

The vital roles of biologically relevant cysteines have been discovered from proteins that are promising targets for new drugs or chemical tools. Therefore, new electrophilic small molecules that can covalently modulate these cysteines have attracted immense interest. Because of their extremely wide chemical diversity, electrophilic natural products (NPs) have been studied as promising sources of cysteine modulators. Previous studies have developed chemical probes to facilitate the detection and isolation of electrophilic NPs. To address the problems with the current methods, including their low sensitivity, high false-positive rate, and dependence on performing manual processing with a plethora of spectra, we report a chemical probe that can first covalently capture electrophilic NPs from natural resources and then produce sensitive reporter ion signals that are specific for the detected NPs. We applied this untargeted method to explore electrophilic NPs from natural resources and found that the complexity of electrophilic NPs was beyond our expectations. We used this chemical probe to identify a new electrophilic furanosesterterpene (<b>BG-1</b>) from an extract of <i>Ginkgo biloba</i> that targets the Cys207 of acyl-CoA thioesterase 7 (ACOT7).
Analysis of current crowding in thin film contacts from exact field solution (2015)

The paper presents a systematic evaluation of current crowding and spreading resistance in thin film contacts, based on the exact field solution that contains very large contrasts in dimensions and resistivity. It is found that current crowding becomes more severe as the interface specific contact resistivity decreases, the resistivity ratio of the contact electrode to the thin film decreases, or the thickness of either the contact or the thin film decreases. The current transfer length from our exact field solution is compared to that of transmission line model (TLM), , where is the interface specific contact resistivity, and ρsh is the sheet resistance of the thin film under contact. It is found that, if is small, is bounded by the smaller of the two dimensions—thin film thickness and contact size. As increases, increases, but saturates at a constant value, determined by the smaller of the two dimensions—contact size and . The total contact resistance is decomposed into three components: the interface resistance due to , the spreading resistance due to current crowding, and the resistance due to the contact electrode. Unambiguously identified, each component is explicitly evaluated and compared in detail.
In vivo turnover studies of C-reactive protein and lipoproteins in the rabbit. (1984)

Clearance from the plasma of 125I-labelled rabbit C-reactive protein (CRP) was significantly slower in animals undergoing an acute phase response (T1/2, mean +/- s.d., 6.48 +/- 1.4 h, n = 4) than in normal rabbits (3.17 +/- 0.4 h, n = 4), P less than 0.01. In contrast there was no difference between the rates of clearance of CRP in rabbits on a normal diet and hypercholesterolaemic rabbits, the plasma of which contained high levels of beta-VLDL with which CRP is known to form circulating complexes. Furthermore the apparent rates of clearance of 125I-labelled beta-VLDL, VLDL and LDL did not differ between normal rabbits and rabbits undergoing an acute phase response. The significance of these findings is discussed.
A negative regulator linking chromosome segregation to developmental transcription in <i>Bacillus subtilis</i> (1998)

The SpoOJA and SpoOJB proteins of Bacillus subtilis are similar to the ParA and ParB plasmid-partitioning proteins, respectively, and mutation of spoOJB prevents the expression of stage II genes of sporulation. This phenotype is a consequence of SpoOJA activity in the absence of SpoOJB, and its basis was unknown. In the studies reported here, SpoOJA was found specifically to dissociate transcription initiation complexes formed in vitro by the phosphorylated sporulation transcription factor SpoOA and RNA polymerase with the spollG promoter. This repressor-like activity is likely to be the basis for preventing the onset of differentiation in vivo. SpoOJB is known to neutralize SpoOJA activity in vivo and also to interact with a mitotic-like apparatus responsible for chromosome partitioning. These data suggest that SpoOJA and SpoOJB form a regulatory link between chromosome partition and development gene expression.
Mechanism for the opsin shift of retinal's absorption in bacteriorhodopsin (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism for the opsin shift of retinal's absorption in bacteriorhodopsinJohan. Lugtenburg, Maria. Muradin-Szweykowska, Carola. Heeremans, and Johannes A. PardoenCite this: J. Am. Chem. Soc. 1986, 108, 11, 3104–3105Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://pubs.acs.org/doi/10.1021/ja00271a050https://doi.org/10.1021/ja00271a050research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A Cell-Free Transcription System for the Hyperthermophilic Archaeon Pyrococcus Furiosus (1996)

We describe here the establishment of a cell-free transcription system for the hyperthermophilic Archaeon Pyrococcus furiosus using the cloned glutamate dehydrogenase (gdh) gene as template. The in vitro system that operated up to a temperature of 85 degrees C initiated transcription 23 bp downstream of a TATA box located 45 bp upstream of the translational start codon of gdh mRNA, at the same site as in Pyrococcus cells. Mutational analyses revealed that this TATA box is essential for in vitro initiation of transcription. Pyrococcus transcriptional components were separated into at least two distinct transcription factor activities and RNA polymerase. One of these transcription factors could be functionally replaced by Methanococcus aTFB and Thermococcus TATA bind- ing protein (TBP). Immunochemical analyses demonstrated a structural relationship between Pyrococcus aTFB and Thermococcus TBP. These findings indicate that a TATA box and a TBP are essential components of the Pyrococcus transcriptional machinery.
Adaptive magnetic resonance image guided radiation for intact localized prostate cancer how to optimally test a rapidly emerging technology (2022)

The number and scope of trials evaluating MRI-guided RT for localized prostate cancer is limited. Yet multiple promising opportunities to test this technology and potentially improve outcomes for men with prostate cancer undergoing definitive RT exist. Attention, in the form of multi-institutional randomized trials, is needed.
The effect of citicoline oral solution on quality of life in patients with glaucoma: the results of an international, multicenter, randomized, placebo-controlled cross-over trial (2023)

This is the first placebo-controlled clinical study evaluating the effect of a medical treatment aiming at improving vision-related quality of life in glaucomatous patients.
Laboratory Development of a Novel, Simultaneous Cake-Cleanup and Gravel-Packing System for Long, Highly-Deviated or Horizontal Open-Hole Completions (1998)

Laboratory Development of a Novel, Simultaneous Cake-Cleanup and Gravel-Packing System for Long, Highly-Deviated or Horizontal Open-Hole Completions M. Parlar; M. Parlar Schlumberger Search for other works by this author on: This Site Google Scholar R.J. Tibbles; R.J. Tibbles Schlumberger Search for other works by this author on: This Site Google Scholar F.F. Chang; F.F. Chang Schlumberger Search for other works by this author on: This Site Google Scholar D. Fu; D. Fu Schlumberger Search for other works by this author on: This Site Google Scholar L. Morris; L. Morris Schlumberger Search for other works by this author on: This Site Google Scholar M. Davison; M. Davison Schlumberger Search for other works by this author on: This Site Google Scholar P.S. Vinod; P.S. Vinod Schlumberger Search for other works by this author on: This Site Google Scholar A. Wierenga A. Wierenga Schlumberger Search for other works by this author on: This Site Google Scholar Paper presented at the European Petroleum Conference, The Hague, Netherlands, October 1998. Paper Number: SPE-50651-MS https://doi.org/10.2118/50651-MS Published: October 20 1998 Cite View This Citation Add to Citation Manager Share Icon Share Twitter LinkedIn Get Permissions Search Site Citation Parlar, M., Tibbles, R.J., Chang, F.F., Fu, D., Morris, L., Davison, M., Vinod, P.S., and A. Wierenga. "Laboratory Development of a Novel, Simultaneous Cake-Cleanup and Gravel-Packing System for Long, Highly-Deviated or Horizontal Open-Hole Completions." Paper presented at the European Petroleum Conference, The Hague, Netherlands, October 1998. doi: https://doi.org/10.2118/50651-MS Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll ProceedingsSociety of Petroleum Engineers (SPE)SPE Europec featured at EAGE Conference and Exhibition Search Advanced Search This paper was prepared for presentation at the 1998 SPE European Petroleum Conference held in The Hague, The Netherlands, 20-22 October 1998. Keywords: caco 3, completion, enzyme, directional drilling, laboratory development, upstream oil & gas, drilling fluid formulation, packing, drilling operation, cake removal Subjects: Drilling Operations, Drilling Fluids and Materials, Directional drilling, Drilling fluid selection and formulation (chemistry, properties), Sand Control This content is only available via PDF. 1998. Society of Petroleum Engineers You can access this article if you purchase or spend a download.
Visual content fingerprinting and search an MPEG perspective (2014)

Our society is creating, storing and using an ever increasing volumes of digital multimedia content. We have access to hundreds of billions of images and videos on the Internet, in the archives of professional content creators and owners, and in the personal libraries of home users. In this context, content-based identification of images' and videos and visual search capabilities are essential enablers for a range of applications that require fast, robust and efficient algorithms. The interoperability of the technologies and systems is also an important consideration. During the lecture Miroslaw Bober will review the latest advances in content fingerprinting and visual search and how they impact related standardisation efforts within the MPEG group. In particular will present the MPEG Visual Signatures, which include the Image Signature and Video Signature content description tools. The Visual Signatures are designed specifically to enable fast and robust identification of near duplicate or derived (modified) visual content in large-scale databases. We will also look at the latest addition to the MPEG family of standards: Compact Descriptors for Visual Search (CDVS). Achieving a state-of-the-art identification and recognition performance, the applications are numerous and include rights management and monetization, distribution management, usage monitoring, and professional or personal database management.
Actinic Keratosis: Rationale and Management (2014)

Actinic keratoses (AKs) are common skin lesions heralding an increased risk of developing squamous cell carcinoma (SCC) and other skin malignancies, arising principally due to excessive ultraviolet (UV) exposure. They are predominantly found in fair-skinned individuals, and increasingly, are a problem of the immunosuppressed. AKs may regress spontaneously, remain stable or transform to invasive SCC. The risk of SCC increases for those with more than 5 AKs, and the majority of SCCs arise from AKs. The main mechanisms of AK formation are inflammation, oxidative stress, immunosuppression, impaired apoptosis, mutagenesis, dysregulation of cell growth and proliferation, and tissue remodeling. Human papilloma virus has also been implicated in the formation of some AKs. Understanding these mechanisms guides the rationale behind the current available treatments for AKs. One of the main principles underpinning the management of AKs is that of field cancerization. Wide areas of skin are exposed to increasing amounts of UV light and other environmental insults as we age. This is especially true for the head, neck and forearms. These insults do not target only the skin where individual lesions develop, but also large areas where crops of AKs may appear. The skin between lesions is exposed to the same insults and is likely to contain as-yet undetectable preclinical lesions or areas of dysplastic cells. The whole affected area is known as the 'field'. Management is therefore divided into lesion-directed and field-directed therapies. Current therapies include lesion-directed cryotherapy and/or excision, and topical field-directed creams: 5-fluorouracil, imiquimod, diclofenac, photodynamic therapy and ingenol mebutate. Combining lesion- and field-directed therapies has yielded good results and several novel therapies are under investigation. Treatment is variable and tailored to the individual making a gold standard management algorithm difficult to design. This literature review article aims to describe the rationale behind the best available therapies for AKs in light of current understanding of pathophysiology and epidemiology. A PubMed and MEDLINE search of literature was performed between January 1, 2000 and September 18, 2013. Where appropriate, articles published prior to this have been referenced. This is not a systematic review or meta-analysis, but aims to highlight the most up to date understanding of AK disease and its management.
Attack surface reduction for commodity OS kernels (2011)

Kernel vulnerabilities are a major current practical security problem, as attested by the weaknesses and flaws found in many commodity operating system kernels in recent years. Ever-growing code size in those projects, due to the addition of new features and the reluctance to remove legacy support, indicate that this problem will remain a severe system security threat in the foreseeable future. Reactive measures such as bug fixes via code reviews and testing, while effective, can only alleviate the issue. Furthermore, common practices in system hardening often focus on complex and sometimes hard to achieve goals that require extensive manual intervention such as security policies for sandboxing.
Physics-Based Design and Optimization of Schottky Diode Frequency Multipliers for Terahertz Applications (2010)

Planar Schottky diode frequency multipliers are by far the most employed devices for local oscillator (LO) power generation at terahertz frequencies. In order to push up to the limit the available LO power at terahertz frequencies, the use of accurate physics-based simulation tools is highly necessary to develop multiplier circuits with the highest performance. This paper investigates the potential capabilities of Schottky multipliers for LO power generation up to 2.4 THz by means of an in-house computer-aided design tool that combines harmonic balance techniques with an accurate physics-based numerical model of the semiconductor device. According to numerical simulation results, a 32-μW LO power could be theoretically achieved with a 2.4-THz LO chain at room temperature from a 150-mW W-band solid-state LO source. This demonstrates that there is still a broad margin for the improvement of state-of-the-art terahertz LO power sources.
The effect of grapefruit juice on cyclosporine and prednisone metabolism in transplant patients (1995)

Grapefruit juice inhibits the metabolism of cyclosporine for a brief period after administration, which may be explained by the inhibition of cytochrome P450 enzymes in the gut wall and to a lesser extent by inhibition of these enzymes in the liver. Grapefruit juice can be one of the factors leading to intraindividual variability in the pharmacokinetics of cyclosporine. Grapefruit juice had no significant effect on the metabolism of prednisone or prednisolone.
Functional CD4 T cell subset interplay in an intact immune system (1993)

Immunization with human collagen IV has been shown to lead to the selective activation of Th-1 and Th-2-like cells in vivo depending on the I-A genotype of the mice. Mice expressing I-As generate Th-1 cells, and mice expressing I-Ab generate Th-2 cells after immunization. We examined the response of (bxs)F1 hybrid mice to determine the types of CD4 T cell activated. We found that Th-1-like responses dominated, in that CD4 T cells from human collagen IV-primed mice displayed good proliferative responses and little ability to induce antibody formation, and secreted IFN-gamma and not IL-5. Most of the Th-1-like activity of F1 hybrid T cells was I-As restricted. Inhibition of Th-1 cell priming using anti-I-As antibody administered with the priming Ag in vivo revealed Th-2-like activity, in that the CD4 T cells now secreted IL-5 and not IFN-gamma and induced antibody formation. Additional studies indicated that anti-IFN-gamma treatment in vivo also revealed Th-2 cells, suggesting that I-As-restricted CD4 T cells producing or controlling the production of IFN-gamma suppress Th-2 priming.
Broadband sources in the 1&amp;#x2013;3 THz range (2009)

Broadband electronically tunable sources in the terahertz range are a critical technology for enabling space-borne as well as ground-based applications. By power-combining MMIC amplifier and frequency tripler chips, we have recently demonstrated >1 mW of output power at 900 GHz. This source provides a stepping stone to enable sources in the 2-3 THz range that can sufficiently pump multi-pixel imaging arrays.