The platelet count at initial autologous peripheral blood stem cell harvest does not influence platelet engraftment after stem cell transplantation (2006)

Many factors influence marrow recovery after autologous peripheral blood stem cell (PBSC) transplantation. The status of the patient’s bone marrow function at harvesting may certainly be an important factor. This study was conducted to evaluate whether the platelet count at the initial stem cell harvest predicts time to platelet and neutrophil engraftment after transplantation. The data of 96 consecutive patients who underwent autologous PBSC transplantation between 2001 and 2004 were reviewed. Data collected included diagnosis, date of diagnosis, date of first harvest, number of harvests to obtain prerequisite number of CD34+ cells, platelet and neutrophil counts at initial harvest, and time to platelet and neutrophil engraftment. An adequate target CD34+ cell number was >2.5 × 106/kg patient weight. The majority of patients had multiple myeloma (45%), followed by non-Hodgkin’s lymphoma (25%), Hodgkin’s Disease (17%), and others (13%). Two collection groups were identified, 1 group requiring only 1 collection period and a second group requiring more than one. Seventy-one patients required 1 collection period of up to 5 consecutive days of stem cell harvest. The average harvest time to obtain the required numbers of stem cells was 3.16 days. The average platelet count at initial harvest was 187,000/uL. Average time to platelet engraftment was 19.2 days and to neutrophil engraftment was 11.6 days. Sixteen patients required >1 peripheral stem cell collection periods. For these patients, the time to platelet engraftment was 22.7 days and to neutrophil engraftment was 12.2 days. Nine patients did not have platelet engraftment because they either died before platelet engraftment or their platelets did not engraft secondary to relapse of disease. The average initial count of this group was 187,000/uL, similar to the other patient group. There was no correlation between platelet count at first harvest and time to platelet engraftment (r = −0.12141). Platelet engraftment time did not correlate with neutrophil engraftment (r = 0.1). In conclusion, patients who required >1 peripheral stem cell collection period, have delayed engraftment of platelets and to lesser extent delayed neutrophil engraftment, when compared to patients requiring only one collection period. Many factors influence marrow recovery after autologous peripheral blood stem cell (PBSC) transplantation. The status of the patient’s bone marrow function at harvesting may certainly be an important factor. This study was conducted to evaluate whether the platelet count at the initial stem cell harvest predicts time to platelet and neutrophil engraftment after transplantation. The data of 96 consecutive patients who underwent autologous PBSC transplantation between 2001 and 2004 were reviewed. Data collected included diagnosis, date of diagnosis, date of first harvest, number of harvests to obtain prerequisite number of CD34+ cells, platelet and neutrophil counts at initial harvest, and time to platelet and neutrophil engraftment. An adequate target CD34+ cell number was >2.5 × 106/kg patient weight. The majority of patients had multiple myeloma (45%), followed by non-Hodgkin’s lymphoma (25%), Hodgkin’s Disease (17%), and others (13%). Two collection groups were identified, 1 group requiring only 1 collection period and a second group requiring more than one. Seventy-one patients required 1 collection period of up to 5 consecutive days of stem cell harvest. The average harvest time to obtain the required numbers of stem cells was 3.16 days. The average platelet count at initial harvest was 187,000/uL. Average time to platelet engraftment was 19.2 days and to neutrophil engraftment was 11.6 days. Sixteen patients required >1 peripheral stem cell collection periods. For these patients, the time to platelet engraftment was 22.7 days and to neutrophil engraftment was 12.2 days. Nine patients did not have platelet engraftment because they either died before platelet engraftment or their platelets did not engraft secondary to relapse of disease. The average initial count of this group was 187,000/uL, similar to the other patient group. There was no correlation between platelet count at first harvest and time to platelet engraftment (r = −0.12141). Platelet engraftment time did not correlate with neutrophil engraftment (r = 0.1). In conclusion, patients who required >1 peripheral stem cell collection period, have delayed engraftment of platelets and to lesser extent delayed neutrophil engraftment, when compared to patients requiring only one collection period.