gebhart/patrepeval huggingface dataset:
Factors Determining Sensitivity and Resistance of Tumor Cells to Arsenic Trioxide (2012)

Previously, arsenic trioxide showed impressive regression rates of acute promyelocytic leukemia. Here, we investigated molecular determinants of sensitivity and resistance of cell lines of different tumor types towards arsenic trioxide. Arsenic trioxide was the most cytotoxic compound among 8 arsenicals investigated in the NCI cell line panel. We correlated transcriptome-wide microarray-based mRNA expression to the IC(50) values for arsenic trioxide by bioinformatic approaches (COMPARE and hierarchical cluster analyses, Ingenuity signaling pathway analysis). Among the identified pathways were signaling routes for p53, integrin-linked kinase, and actin cytoskeleton. Genes from these pathways significantly predicted cellular response to arsenic trioxide. Then, we analyzed whether classical drug resistance factors may also play a role for arsenic trioxide. Cell lines transfected with cDNAs for catalase, thioredoxin, or the anti-apoptotic bcl-2 gene were more resistant to arsenic trioxide than mock vector transfected cells. Multidrug-resistant cells overexpressing the MDR1, MRP1 or BCRP genes were not cross-resistant to arsenic trioxide. Our approach revealed that response of tumor cells towards arsenic trioxide is multi-factorial.
&lt;title&gt;Feature-based watermarking of 2D vector data&lt;/title&gt; (2003)

This paper deals with the issue of watermarking 2D-vector data (point coordinates) which are used in Geographical Information Systems (GIS). The tolerance range of the coordinates is used to embed the information. As an embedding constraint no violation of the tolerance range at each point may occur. In the first step of our approach we lay a rectangular grid over the map, where the origin, the extension, and the subdivision of this grid is only known by the embedder. Based on a secret key we choose two disjunctive sets A and B of grid elements namely "patches". Now these selected elements are further divided into smaller subareas or "subpatches". In subpatches belonging to set A the distances of points to a reference line within each subpatch are decreased while the distances of subpatches of set B are unchanged. In the retrieving procedure we consider all subpatches belonging to the sets A and B and calculate for each of the two sets their sample variance. The decision whether the map is watermarked with a certain key or not is based on this feature and is made with the help of a hypothesis test. The proposed method is robust against attacks changing the coordinates within the tolerance range and against polygon simplification procedures.
Improving service coordination in municipal government with the Shared Data Manager (2012)

In this paper, we describe our work in the design and evaluation of a tool, the Shared Data Manager, to be used to enable automatic data sharing capabilities for municipal government applications. In an earlier study, we determined that municipal government employees rely heavily on manual methods for data sharing, which is time-consuming and error-prone. We describe in detail our findings from a two-week evaluation of the Shared Data Manager system with municipal employees. Overall, municipal employees found the tool to be useful for sharing data between departments and customizing data sharing access controls.
Latency arbitrage, market fragmentation, and efficiency (2013)

We study the effect of latency arbitrage on allocative efficiency and liquidity in fragmented financial markets. We propose a simple model of latency arbitrage in which a single security is traded on two exchanges, with aggregate information available to regular traders only after some delay. An infinitely fast arbitrageur profits from market fragmentation by reaping the surplus when the two markets diverge due to this latency in cross-market communication. We develop a discrete-event simulation system to capture this processing and information transfer delay, and using an agent-based approach, we simulate the interactions between high-frequency and zero-intelligence trading agents at the millisecond level. We then evaluate allocative efficiency and market liquidity arising from the simulated order streams, and we find that market fragmentation and the presence of a latency arbitrageur reduces total surplus and negatively impacts liquidity. By replacing continuous-time markets with periodic call markets, we eliminate latency arbitrage opportunities and achieve further efficiency gains through the aggregation of orders over short time periods.
Coherent excitation of a nonlinear silicon microcavity (2014)

Coherent excitation of a microcavity resonance leading to enhanced nonlinear interaction is experimentally demonstrated for the first time. A tailored chirped pulse maintains the cavity enhancement effect, despite the resonance nonlinear frequency shift.
Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation (2017)

The Editors recently became aware that some of the flow cytometry plots in this article were duplicated and used to represent different samples. Specifically, in Figure In addition, in Figure The authors were unable to provide the original data for these figures.
An Undergraduate Optical Engineering Course (1975)

An upper level undergraduate survey course in optical engineering is described. The goal of this course is to provide students with a working knowledge of optics and optical systems as applied to modern engineering problems.
Somatic Mutations Predict Acute Myeloid Leukemia Years Before Diagnosis (2017)

ABSTRACT Background Somatic mutations observed in clonal hematopoiesis are associated with increased age and risk of hematological malignancies. However, the limited number of acute myeloid leukemia (AML) patients in studies of clonal hematopoiesis thus far has precluded determination of the spectrum of mutations leading to AML and their impact on risk and time to diagnosis. Methods The relationship between baseline mutations and subsequent AML was determined in a case-control study design. 212 women eventually diagnosed with AML (median time: 9.8 years) were identified from the Women’s Health Initiative cohort alongside 212 matched AML-free controls. Deep sequencing of 67 genes was performed on DNA isolated from peripheral blood to detect subclonal mutations. Results The presence of any mutation was associated with increased odds of eventual AML (odds ratio [OR] 4.0; 95% confidence interval [CI], 2.5-6.3). These odds were further elevated with mutations in IDH1/2 (OR 8.4; 95% CI, 1.4-51.9), TP53 (OR 54.2; 95% CI, 2.9-1017.7), or spliceosome genes (OR 5.6; 95% CI, 1.5-20.6). Eventual AML diagnosis occurred in all or most participants with mutations in TP53 (N=23/23) or IDH1/2 (N=15/16). Mutations indicated sooner AML diagnosis (median 8.0 vs. 11.9 years; P &lt; 0.001) with TP53 mutations demonstrating increased odds of AML within 5 years (OR 3.6; 95% CI, 1.4-9.1). Conclusions Mutations are present in peripheral blood of AML patients a decade prior to AML diagnosis with mutations in TP53 producing especially rapid presentation. Strategies for monitoring of high-risk populations are needed and clinical trials of potential early interventions can be considered.
Data from 5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-Mediated Apoptosis (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Patients with acute myeloid leukemia (AML) frequently do not respond to conventional therapies. Leukemic cell survival and treatment resistance have been attributed to the overexpression of B-cell lymphoma 2 (BCL-2) and aberrant DNA hypermethylation. In a phase Ib study in elderly patients with AML, combining the BCL-2 selective inhibitor venetoclax with hypomethylating agents 5-azacitidine (5-Aza) or decitabine resulted in 67% overall response rate; however, the underlying mechanism for this activity is unknown.&lt;/p&gt;Experimental Design:&lt;p&gt;We studied the consequences of combining two therapeutic agents, venetoclax and 5-Aza, in AML preclinical models and primary patient samples. We measured expression changes in the integrated stress response (ISR) and the BCL-2 family by Western blot and qPCR. Subsequently, we engineered &lt;i&gt;PMAIP1&lt;/i&gt; (NOXA)- and &lt;i&gt;BBC3&lt;/i&gt; (PUMA)-deficient AML cell lines using CRISPR-&lt;i&gt;Cas9&lt;/i&gt; methods to understand their respective roles in driving the venetoclax/5-Aza combinatorial activity.&lt;/p&gt;Results:&lt;p&gt;In this study, we demonstrate that venetoclax and 5-Aza act synergistically to kill AML cells &lt;i&gt;in vitro&lt;/i&gt; and display combinatorial antitumor activity &lt;i&gt;in vivo&lt;/i&gt;. We uncover a novel nonepigenetic mechanism for 5-Aza–induced apoptosis in AML cells through transcriptional induction of the proapoptotic BH3-only protein NOXA. This induction occurred within hours of treatment and was mediated by the ISR pathway. NOXA was detected in complex with antiapoptotic proteins, suggesting that 5-Aza may be “priming” the AML cells for venetoclax-induced apoptosis. &lt;i&gt;PMAIP1&lt;/i&gt; knockout confirmed its major role in driving venetoclax and 5-Aza synergy.&lt;/p&gt;Conclusions:&lt;p&gt;These data provide a novel nonepigenetic mechanism of action for 5-Aza and its combinatorial activity with venetoclax through the ISR-mediated induction of &lt;i&gt;PMAIP1&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Over-the-Air Phase Measurement and Calibration Method for 5G mmW Phased Array Radio Transceiver (2019)

In this paper, over-the-air (OTA) phase measurement and calibration method for a fifth generation (5G) millimeter wave radio frequency unit is presented. The phase error measurements are done for both receiver and transmitter. The measurement results are used to calibrate the individual antenna ports of the antenna array system so that accurate radiation patterns can be formed. In order to confirm the calibration, the radiation patterns are measured with a 100 MHz wide 28 GHz 5G New Radio communication signal. The measurements show that the calibration improves the maximum power level flatness of radiation patterns and reduces side lobe levels.
Development of a RIMS-based FFDL system at the experimental fast reactor JOYO (2001)

A series of experiments has been examined the applicability of RIMS to the trace xenon isotopic analysis needed for the tagging gas FFDL. The measurement of the JOYO cover gas equivalent clarified the existence of non-resonantly produced argon ions which could disturb the trace analysis. We proposed to apply the mass gating and solved the problem, which enabled us to succeed in demonstrating that RIMS satisfies the requirement for the FFDL at the MONJU.
[η<sup>5</sup>-2,3-Bis(trimethylsilyl)-2,3-dicarba-<i>nido</i>-hexaborane(2−)]chlorido(<i>N</i>,<i>N</i>,<i>N</i>′,<i>N</i>′-tetramethylethylenediamine)dysprosium(III) (2008)

The structure of the title compound, [Dy(C(8)H(22)B(4)Si(2))Cl(C(6)H(16)N(2))], reveals that a center of symmetry exists within the dimeric half-sandwich units. Within each half-sandwich, the Dy(III) ion is coordinated by the five-membered ring of the carborane, tetramethylethyl-enediamine and the chloride ion.
Population pharmacokinetic analysis of certolizumab pegol in patients with Crohn's disease (2015)

Certolizumab pegol (CZP), an anti-tumor necrosis factor α agent, is an effective therapy for Crohn's disease (CD). A population pharmacokinetic (PK) analysis of subcutaneously administered CZP was performed using data from 2157 CD patients from 9 separate studies. The aim was to determine which covariates influence the disposition of CZP. The final CZP population PK model consisted of a baseline, first-order absorption, and 1-compartment disposition. CZP antibodies were treated as a structural model covariate and caused apparent clearance (CL/F) to increase from 0.685 to 2.74 L/day. Body surface area (BSA) influenced both CL/F and apparent volume of distribution (V/F) in a linear fashion; both parameters increased by more than 53% and 49%, respectively, across the range of BSA measurements in the data. Albumin influenced CZP CL/F in a nonlinear fashion; CL/F decreased from 1.05 to 0.613 L/day with increasing albumin concentrations in antibody-negative patients. C-reactive protein (CRP) had a borderline influence and CL/F increased by more than 20% across the range of CRP measurements in the data set. Race had a minor influence on V/F. The determined covariates' impact on CZP disposition may be of clinical utility in CZP therapy of CD patients when the PK/pharmacodynamic relationship becomes available.
RECONSTITUTION OF CYTOTOXIC T LYMPHOCYTE ACTIVITY (1987)

Longitudinal studies over an eight-month period have been performed to follow the T killer response restoration after allogeneic bone marrow transplantation (BMT). The capacity of the patient's peripheral blood mononuclear cells (PBM) to develop cytotoxic effector cells directed either against allogeneic cells or against Epstein-Barr virus (EBV) or Herpes-simplex virus-1 (HSV-1)-infected syngeneic cells was tested monthly. The data suggest that in most cases the cytotoxic T lymphocyte (CTL) activity, either allospecific or directed against EBV and the HSV-1 specific killer (HNK) responses, is quickly reconstituted in BMT patients. Roughly, these activities seem to be normal after two months following classic nondepleted grafting. However, in the two patients who had received a T-cell-depleted graft, the restoration was delayed. Furthermore, in the majority of the patients, once reconstituted the killer responses were relatively stable and the occurrence or absence of graft-versus-host diseases (GVHD) did not significantly modify these responses.
Performance of Superposition Coding for Downlink Coordinated Two-Point System (2013)

In this correspondence, we consider a downlink coordinated two-point (DCTP) system, where two users communicate with two base stations. A superposition-coding (SC)-based transmission scheme is proposed to improve its error performance. A joint interference-cancellation and maximum-ratio-combining (IC-MRC) detection algorithm is proposed for the SC scheme, which reduces the error probability of the system compared with the classic SC (CSC) detector. Closed-form expressions of the bit error probability (BEP) of the proposed scheme are derived. Under the same power and time constraint, a signal-to-noise ratio (SNR) gain is obtained when the SC scheme is employed. Tight upper bounds of the BEP are derived to provide insight. Optimal power allocation is also derived to optimize the system performance in terms of the BEP.
Abstract 14303: Structural Remodeling in the Left Ventricular Myocardium Underlies Systolic Dysfunction in Myocardial Infarction (2021)

Introduction: Myocardial infarction (MI) leads to myofiber death and the formation of a fibrotic scar in the left ventricular free wall (LVFW) myocardium. Acute MI induces remodeling events in the LV consisting of alterations in the architecture and biomechanical properties of the LVFW, collectively leading to LV systolic dysfunction. We implemented a multi-modality pipeline bridging architectural remodeling, LVFW passive behavior adaptation, and ventricular dysfunction in MI. We hypothesize that biomechanical remodeling of the LV serves as an important predictor of clinical outcomes in MI. Methods: MI was induced in rats via the ligation of the LAD artery, and hearts were harvested at five time points: pre-MI, and 1-wk to 4-wk post-MI (n=6 for each time point). Echocardiography and terminal LV catheterization were performed. LVFW specimens were harvested and subjected to biaxial testing, followed by picrosirius red staining. Histological slides were analyzed to quantify fiber architecture. Results: Comparisons for 3-wk MI versus control groups are reported (animal-specific results for representative rats are shown in Fig. 1). Echocardiography imaging showed a decrease in EF (84±5 vs 73±10%; p=0.053) and a decrease in ESV (0.122±0.045 vs 0.31±0.195ml; p=0.013). LV catheterization revealed a decrease in SV (50±0.86 vs 10±0.38μL; p&lt;0.001) and an increase in peak systolic pressure (36.62±0.87 vs 44.91±0.99 mmHg; p&lt;0.001), indicating systolic dysfunction. Biaxial testing revealed longitudinal stiffening of the LVFW at 3-wk post-MI. Scarring and a shift in myofiber orientation towards the longitudinal direction corroborated changes in the LVFW mechanical behavior in the MI group. Conclusions: LV systolic dysfunction in MI is significantly influenced by disruption in myofiber architecture and fiber orientation remodeling in the LVFW. Assessment of LVFW remodeling events provides important incremental information over traditional organ-level indices.
ChemInform Abstract: Magnetic Excitations in Polyoxometalate Clusters Observed by Inelastic Neutron Scattering: Evidence for Ferromagnetic Exchange Interactions and Spin Anisotropy in the Tetrameric Nickel(II) Cluster [Ni<sub>4</sub>(H<sub>2</sub>O)<sub>2</sub> (PW<sub>9</sub>O<sub>34</sub>)<sub>2</sub>]<sup>10‐</sup> and Comparison with the Magnetic Properties. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Computerized order entry: Hospital versus pharmacy-based systems (1990)

Journal Article Computerized order entry: Hospital versus pharmacy-based systems Get access John Poikonen, John Poikonen Western Regional Manager Megasource, Inc., 10780 Gabacho Drive, San Diego, CA 92124 Search for other works by this author on: Oxford Academic Google Scholar Bruce B. Clutcher, Bruce B. Clutcher Senior Installation Director Shared Medical Systems, 51 Valley Stream Parkway, Malvern, PA 19355 Search for other works by this author on: Oxford Academic Google Scholar Harm Scherpbier, M.D. Harm Scherpbier, M.D. Systems Analyst Shared Medical Systems, 51 Valley Stream Parkway, Malvern, PA 19355 Search for other works by this author on: Oxford Academic Google Scholar American Journal of Hospital Pharmacy, Volume 47, Issue 11, 1 November 1990, Pages 2461–2462, https://doi.org/10.1093/ajhp/47.11.2461 Published: 01 November 1990
Ferromagnetic domain distribution in thin films during magnetization reversal (2002)

It is shown that polarized neutron reflectometry can determine in a model-free way not only the mean magnetization of a ferromagnetic thin film at any point of a hysteresis cycle, but also the mean-square dispersion of the magnetization vectors of its lateral domains. This technique is applied to elucidate the mechanism of magnetization reversal of an exchange-biased Co/CoO bilayer. The reversal process above the blocking temperature ${T}_{b}$ is governed by uniaxial domain switching, while below ${T}_{b}$ the reversal of magnetization for the trained sample takes place with substantial domain rotation.
Directivity Enhancement and Spurious Radiation Suppression in Leaky-Wave Antennas Using Inductive Grid Metasurfaces (2015)

Fabry-Perot antennas (FPA) achieve high broadside directivity due to the simultaneous excitation of a pair of nearly degenerate TE/TM leaky-wave modes using a partially-reflecting surface on top of a ground plane. This partially-reflecting surface can be obtained using a dielectric superstrate or via a capacitive or inductive metasurface (MTS). By using an equivalence between the conventional dielectric superstrate and the MTS-based structures in terms of the dominant TE/TM modes, we show that the use of inductive grid MTSs leads to a directivity enhancement. A higher roll-of in the radiation patterns is achieved as a result of the intrinsic suppression of the spurious TM0 leaky wave mode. This suppression is mathematically demonstrated and validated with full-wave simulations. The achieved improvement in more than 1 dB for inductive strip grid based MTS with respect to dielectric based super-layers, for the same frequency band of 2.5%, is verified with measurements. Two prototypes, with the dielectric superlayer and inductive strip grid based MTS, have been fabricated and measured supporting the claim of this work.
Preparation and Optimization of In Situ Gel Loaded with Rosuvastatin-Ellagic Acid Nanotransfersomes to Enhance the Anti-Proliferative Activity (2020)

The objective of this study was to develop an optimized sustained-release nanotransfersomes (NTS) based in situ gel formulation of rosuvastatin (RO) combined with ellagic acid (EA) antioxidant, to enhance cytotoxic and anti-proliferative activity against tongue carcinoma. The concentrations of lecithin, Tween 80, and d-tocopherol polyethylene glycol succinate (TPGS) were considered as independent variables. Particle size, entrapment, and stability were selected as dependent variables. The obtained formulation containing 25% lecithin, 20% Tween 80, and TPGS 15% fulfilled the prerequisites of the optimum formulation. RO-NTS loaded in situ gel was prepared and optimized for concentrations of Poloxamer 407, and Carbopol, using statistical design. Drug release from in situ gel showed a sustained release profile. The RO IC50 was decreased by half for the in situ gel in comparison to plain RO and RO-EA-NTS. A significant amount of caspase-3 was detected in all the formulation treatments. The studies indicated that EA's synergistic anti-oxidant effect owing to a high affinity to the PGP efflux transporter and higher penetration in the RO-NTS formulation led to a higher inhibition against human chondrosarcome-3 cancer cell lines. RO-EA NTS-loaded in situ gel had a sustained release that could be significant in localized therapy as an alternative to surgery in the treatment of aggressive tongue carcinoma.
Archaeological Sites as Peripheral Destinations. Exploring Big Data on Fieldtrips for an Upcoming Response to the Tourism Crisis after the Pandemic (2021)

Archaeological heritage sites constitute the most recent addition to the tourism supply of Madrid, one of the most visited regions of Spain. In 2003, the Plan de Yacimientos Visitables (Plan of Archaeological Visitable Sites) was implemented, museumising 21 sites. However, the peripheral nature of these sites and the lack of personnel prevent strict control being carried out of who visits them, the practices of these visitors and how they rate the sites. This study proposes a systematic procedure to analyse the data gathered from Twitter and Flickr, in order to determine the most shared archaeological spaces in the years immediately preceding the pandemic, and to assess the perception that the visitors had of them. The information provided is useful for learning about the real weight that these sites have in leisure experiences (school trips, guided tours, recreation, etc.). Now that travel has been restricted due to the pandemic, we should ask whether Spain’s minor heritage is able to structure new proximity tourism routes. This is based on the hypothesis that, until now, these types of heritage have had a very limited role in recreational practices, but offer potential as “outdoor museums” in the present climate.