gebhart/patrepeval huggingface dataset:
OCT and RX validation of metal-ceramic crowns repaired with ceramic material (2011)

Objective: Study's objectives are focused on non-invasive OCT and RX investigations, of interfaces obtained after repairing a metal-ceramic crown with ceramic materials. Material and method: In this study 40 metal-ceramic crowns were involved. Each crown is restoring the first central incisor 1.1. Metallic infrastructure was performed from nickel-chrome WIRON 99 BEGO alloy, and Kiss Ceramic. The defects of 3&times;3mm were created into ceramic material in the buccal-incisal area with a grinding instrument. The samples were divided into two groups and the defects were reconstructed with two different types of ceramic materials: Kiss and Vita Omega. The interfaces between crown and ceramic material used for reparation were Rx and OCT investigated which are both non-invasive, imagistic investigation techniques. For better investigation three-dimensional reconstructions were performed. Results: The interfaces showed defects for both systems used. Major defects such as gaps could be identified at the ceramic-ceramic interface. Also material defects could be observed at the areas of congruence between the two ceramic materials and smaller defects along the interfaces. The defects were present into the deep and superficial layers of interface. The OCT system used a length wave of 1300nm and worked in B-scan mode along the interfaces to be studied while the C-scan mode was only used at the defect areas. Rx investigation detected the macro defects. Conclusions: Time Domain OCT and RX systems were identifying the faulty areas after repairing artificially created defects, of metal-ceramic crowns with ceramic material, hereby enabling us to establish recommendations for the clinical use.
Determination of Tritiated Dexamethasone in Rat Liver and Muscle:  Comparison of Two Sample Preparation Techniques, Combustion and Solubilization, Prior to Liquid Scintillation Counting (1998)

Rats were injected intramuscularly with 20 μCi/kg [3H]dexamethasone, which is a synthetic therapeutic glucocorticoid. After 2 h, the rats were sacrificed, and liver and muscle tissues were taken for assay. 3H radioactivity measurements were performed in a liquid scintillation counter. The objective of this study was to compare two sample preparation techniques, namely, alkaline solubilization versus dry combustion, to release the incorporated radioactivity quantitatively from rat liver and muscle; sample combustion has a recovery of 99 ± 1.0%. In addition, the effect of bleaching the samples with hydrogen peroxide was evaluated and quench correction curves were established. The current data demonstrated that the efficiencies of both methods were similar in the measurement of [3H]dexamethasone incorporated in rat liver and muscle tissues. For muscle, differences in disintegrations per minute (dpm) reached only 0.18%; for liver, the score was 0.78%. In conclusion, knowledge of the total radioactivity present in rat liver and muscle makes these tissues suitable as standard materials for the determination of [3H]dexamethasone extraction recoveries. The high solubilization efficiency of alkaline solubilization strengthens the notion that this method can be used to release glucocorticoid residues from biological samples. Keywords: Dexamethasone; sample preparation; combustion; solubilization; liquid scintillation
Sensitization of human α1- and α2-adrenergic venous responses by guanadrel sulfate (1990)

The alpha 1- and alpha 2-adrenergic venoconstriction in dorsal hand veins of normal subjects was determined by infusion of phenylephrine or clonidine. Oral administration of prazosin reduced the constriction response to phenylephrine but not to clonidine. Subjects were treated for 3 weeks in a randomized crossover design with placebo or guanadrel sulfate. Guanadrel reduced sympathetic tone (i.e., plasma norepinephrine and norepinephrine release rate), whereas venous responses to phenylephrine and clonidine were both augmented during guanadrel treatment. The effect on phenylephrine responses was primarily attributable to a decrease in the median effective concentration with a small increase in maximum response. Clonidine showed a markedly increased maximum response with a small increase in the median effective concentration. Platelet alpha 2-adrenergic receptors increased slightly but there was no change in the amount of platelet pertussis toxin substrate during guanadrel treatment. Thus reduction in sympathetic tone in normal young men results in increased venous responses to both alpha 1- and alpha 2-agonists.
Coupled Simulation of Reservoir Flow, Geomechanics, and Formation Plugging With Application to High-Rate Produced Water Reinjection (2003)

Abstract Produced water re-injection at high rates presents a coupled problem of reservoir flow, formation damage, stress alteration around the injector, and fracture propagation. Accurate prediction of permeability changes, fracture propagation pressure, and fracture dimensions is required for minimization of disposal costs and design of surface equipment. The paper presents the formulation and numerical implementation of a coupled reservoir, damage and geomechanical model which includes the above couplings. Details of the model are first described. A simple empirical damage model, calibrated to field data is then presented. Finally, application of the complete model to high rate reinjection in the Masila Block in Yemen is presented. The model predictions show that it is feasible to sustain over 100,000 BWPD in a single Masila disposal well by injecting above fracture pressure.
Field Instrument for Simultaneous Large Dynamic Range Measurement of Atmospheric Hydrogen Sulfide, Methanethiol, and Sulfur Dioxide (2004)

We describe a membrane-based collection/analysis system that differentially monitors H2S and CH3SH, and to which a conductometric SO2 analyzer using the same collector was coupled. A diffusion scrubber (DS) comprised of a Nafion tube collects H2S selectively while a porous polytetrafluoroethylene (pPTFE) DS collects both H2S and CH3SH. Both gases are measured via their ability to react with fluorescein mercuric acetate (FMA) which results in decreased fluorescence. The limited dynamic range of a negative signal procedure was overcome by using dual DS units comprised of short and long scrubbers, placed serially in the liquid flow line. Different DS designs and membrane materials were investigated. H2S, CH3SH, and SO2 from a biogenic point source were continuously measured, and the H2S/CH3SH data compared well with a standard procedure involving Tedlar bag collection, preconcentration and thermal desorption from a Tenax trap, and measurement by gas chromatography/flame photometric detection. Walkaround portability of the instrument and very large dynamic range measurement of H2S and SO2 were demonstrated around the Mt. Aso volcano.
Correction: Broader Epstein–Barr virus–specific T cell receptor repertoire in patients with multiple sclerosis (2022)

During data analysis for a follow-up project, the authors found that the number of patients who received ocrelizumab infusions in the metadata underlying Fig. The corrected Fig. In addition, in Table The conclusions regarding these data are unchanged.
Enhanced Affinities and Specificities of Consolidated Ligands for the Src Homology (SH) 3 and SH2 Domains of Abelson Protein-tyrosine Kinase (1995)

The possible interrelationships between multiple domains of proteins involved in intracellular signal transduction are complex and not easily investigated. We have synthesized a series of bivalent consolidated ligands, which interact simultaneously with the SH2 and SH3 domain of Abelson kinase in a SH(32) dual domain construct, a portion of native Abelson kinase. Affinities were measured by quenching of intrinsic tryptophan fluorescence. Consolidated ligands have enhanced affinity and specificity compared to monovalent equivalents. Affinity is also dependent on the length of the linker joining the two parts, with an optimum distance similar to that expected from structural models of Abl (SH(32). These results suggest that consolidated ligands may be generally useful reagents for probing structural and functional activities of multidomain proteins.
Poly(A) binds to initiation factors and increases cap-dependent translation in vitro. (1994)

Both the 5' cap (m7GpppN) and the 3' poly(A) tail of eukaryotic mRNAs are important regulators of translation efficiency in vivo. Their function, however, is markedly reduced in in vitro translation systems derived from either rabbit reticulocytes or wheat germ. The impact of exogenous poly(A) on cap-dependent translation was examined in vitro. The translation of uncapped mRNA was preferentially repressed in the presence of exogenous poly(A). As a result, translation became increasingly cap-dependent with the increase in exogenous poly(A). The translation in wheat germ lysate was stimulated by the addition of purified eukaryotic initiation factor (eIF)-4B or eIF-4F; however, addition of poly(A) prevented this eIF-4B- or eIF-4F-mediated stimulation. Addition of eIF-4F or eIF-4B, alone, was not sufficient to restore translation in lysate to which poly(A) had been added. Restoration, however, was observed when eIF-4F, eIF-4B, and eIF-4A were added in combination. These data suggest that 1) exogenous poly(A) may bind to and sequester factors required for translation and 2) that capped messages compete with poly(A) more efficiently for these factors than do uncapped mRNAs. Gel shift analysis of purified initiation factors isolated from wheat germ confirmed that eIF-4B and eIF-4F do in fact form complexes with poly(A) in vitro.
Prognostic utility of serum NT-proBNP (fragments 1-76aa and 13-71aa) and galectin-3 in predicting death and re-hospitalisation due to cardiovascular events in patients with heart failure (2023)

Patients with heart failure (HF) are at a higher risk of rehospitalisation. In this study, we investigated the prognostic utility of galectin-3 (Gal-3) and NT-proBNP fragments (1-76aa and 13-71aa) as biomarkers to predict outcomes for patients with HF. We collected blood samples from patients with HF (n = 101). Gal-3 and NT-proBNP fragments (1-76aa and 13-71aa) concentrations were measured by immunoassay. Survival analysis and Cox proportional regression models were used to determine the prognostic utility of Gal-3 and NT-proBNP fragments. In patients with increased baseline levels of NT-proBNP<sub>1-76</sub> the time to primary endpoint (cardiovascular death or re-hospitalisation) was significantly shorter (p = 0.0058), but not in patient with increased baseline levels of Gal-3 or NTproBNP<sub>13-71</sub>. Patients with increased levels of NT-proBNP<sub>13-71aa</sub> at 1 month showed reduced time to the primary endpoint (p = 0.0123). Our findings demonstrated that Gal-3 and NT-proBNP can be used as prognostic biomarkers to stratify patients with HF.
Improving classifiers with unlabeled weakly-related videos (2011)

Current state-of-the-art object classification systems are trained using large amounts of hand-labeled images. In this paper, we present an approach that shows how to use unlabeled video sequences, comprising weakly-related object categories towards the target class, to learn better classifiers for tracking and detection. The underlying idea is to exploit the space-time consistency of moving objects to learn classifiers that are robust to local transformations. In particular, we use dense optical flow to find moving objects in videos in order to train part-based random forests that are insensitive to natural transformations. Our method, which is called Video Forests, can be used in two settings: first, labeled training data can be regularized to force the trained classifier to generalize better towards small local transformations. Second, as part of a tracking-by-detection approach, it can be used to train a general codebook solely on pair-wise data that can then be applied to tracking of instances of a priori unknown object categories. In the experimental part, we show on benchmark datasets for both tracking and detection that incorporating unlabeled videos into the learning of visual classifiers leads to improved results.
Hippocampus queenslandicus Horne, 2001 – a new seahorse species or yet another synonym? (2007)

During the past six years, 15 new seahorse species (Syngnathidae: Hippocampus) have been described on the basis of morphological characters. This approach is known to be problematic, and most species names in Hippocampus are now considered to be synonyms. Genetic methods have great potential to resolve the confused taxonomy of the genus, but none have yet been incorporated into species descriptions. In the present study, mitochondrial control region and cytochrome b DNA sequences, as well as morphological data from the recently described Queensland seahorse, Hippocampus queenslandicus Horne, 2001, were compared with corresponding data from closely related seahorse species to determine whether there is strong support for distinction of this taxon. The haplotypes of H. queenslandicus were nested among haplotypes belonging to two of the three major Southeast Asian lineages of H. spinosissimus Weber, 1913. Although incomplete lineage sorting characteristic of very recently diverged species cannot be ruled out, the genetic results suggest that H. queenslandicus is paraphyletic. Morphometric analysis further fails to provide strong support for the species status of H. queenslandicus. We conclude that support for the distinctness of H. queenslandicus is weak, and indicate that it is a synonym of H. spinosissimus. The taxonomic validity of other recently described seahorse species should be similarly scrutinised using combined genetic and detailed morphological methods.
Multipolar Hepatic Radiofrequency Ablation Using up to Six Applicators: Preliminary Results Multipolare Radiofrequenzablation der Leber mit bis zu sechs Applikatoren: erste Ergebnisse (2008)

Purpose: To evaluate the clinical feasibility and safety of hepatic radiofrequency (RF) ablation using a multipolar RF system permitting the si- multaneous use of up to six electrodes. Materials and Methods: Ten patients (3 female, 7 male, mean age 61) suffering from 29 hepatic metastases (range: 1 - 5) of different tumors were treated with a modified multipolar RF sys- tem (CelonLab Power, Celon Medical Instru- ments, Teltow, Germany) operating four to six needle-shaped internally cooled RF applicators. The procedure duration, applied energy and gen- erator output were recorded during the interven- tion. The treatment result and procedure-related complications were analyzed. The achieved coa- gulation volume was calculated on the basis of contrast-enhanced CT scans 24 hours after RF ab- lation. Results: Complete tumor ablation was achieved in all cases as determined by the post-interven- tional lack of contrast enhancement in the target region using four applicators in five patients, five applicators in one patient and six applicators in four patients. A mean energy deposition of 353.9 € 176.2 kJ resulted in a mean coagulation volume of 115.9 € 79.5 cm 3 . The mean procedure duration was 74.9 € 21.2 minutes. Four patients showed an intraabdominal hemorrhage which necessitated further interventional treatment (embolization; percutaneous histoacryl injec- tion) in two patients. Conclusion: Multipolar RF ablation of hepatic metastasis with up to six applicators was clini- cally feasible. In our patient population it was as- sociated with an increased risk of intraabdominal bleeding probably due to the multiple punctures associated with the use of multiple applicators.
Learning and the Development of Contexts for Action (2011)

Neurophysiological evidence from animal studies suggests that frontal corticolimbic systems support early stages of learning, whereas later stages involve context representation formed in hippocampus and posterior cingulate cortex. In dense-array EEG studies of human learning, we observed brain activity in medial prefrontal cortex (the medial frontal negativity or MFN) was not only observed in early stages, but, surprisingly, continued to increase as learning progressed. In the present study we investigated this finding by examining MFN amplitude as participants learned an arbitrary associative learning task over three sessions. On the fourth session the same task with new stimuli was presented to assess changes in MFN amplitude. The results showed that MFN amplitude continued to increase with practice over the first three sessions, in contrast to P3 amplitudes. Even when participants were presented with new stimuli in session 4, MFN amplitude was larger than that observed in the first session. Furthermore, MFN activity from the third session predicted learning rate in the fourth session. The results point to an interaction between early and late stages in which learning results in corticolimbic consolidation of cognitive context models that facilitate new learning in similar contexts.
LINKAGE STUDIES IN MANIC DEPRESSIVE ILLNESS. (1992)

De bruyn, A.1; Raeymaekers, P.1; Sandkuijl, L. A.2; Mendelbaum, K.3; Mendlewicz, J.3; Van Broeckhoven, C.1 Author Information
Electrified Powertrain with Multiple Planetary Gears and Corresponding Energy Management Strategy (2021)

Modern hybrid electric vehicles (HEVs) like the fourth generation of Toyota Prius incorporate multiple planetary gears (PG) to interconnect various power components. Previous studies reported that increasing the number of planetary gears from one to two reduces energy consumption. However, these studies did not compare one PG and two PGs topologies at their optimal operation. Moreover, the size of the powertrain components are not the same and hence the source of reduction in energy consumption is not clear. This paper investigates the effect of the number of planetary gears on energy consumption under optimal operation of the powertrain components. The powertrains with one and two PGs are considered and an optimal simultaneous torque distribution and mode selection strategy is proposed. The proposed energy management strategy (EMS) optimally distributes torque demands amongst the power components whilst also controlling clutches (i.e., mode selection). Results show that increasing from one to two PGs reduces energy consumption by 4%.
Supplementary Methods from Antitumor Activity of a Duocarmycin Analogue Rationalized to Be Metabolically Activated by Cytochrome P450 1A1 in Human Transitional Cell Carcinoma of the Bladder (2023)

&lt;p&gt;PDF file - 109K, Methodology for analysis of CYP1 gene and protein expression,Detection of DNA-damage induced gamma-H2AX protein expression, and analysis of ICT2700 metabolism in mouse and human liver ex vivo&lt;/p&gt;
A questionnaire for the assessment of patients' impressions of the risks and benefits of home telecare (2000)

Home telecare is a promising method of improving access to care for rural and urban populations. It requires, however, that patients accept the installation and use of equipment in their home. How patients perceive home telecare may influence its acceptability and diffusion. We developed a questionnaire to assess patients' impressions of the risks and benefits of home telecare. A preliminary 20-item questionnaire was developed and tested on 32 subjects. It proved to be of acceptable reliability (Cronbach's alpha of 0.8) and validity, but three items appeared to be redundant. The final 17-item version was tested twice on 10 more subjects and was found to have high test-retest reliability. Most subjects showed an overall positive attitude towards home telecare and agreed it could improve their health. Many were concerned about being able to trust the equipment. The questionnaire can be used to investigate the acceptance of telemedicine and to improve the design of applications.
Isolation and characterization of ERECTA genes and their expression patterns in common wheat (Triticum aestivum L.) (2013)

The orthologue of Arabidopsis ERECTA gene (ER) in wheat, TaER, is considered to be a promising candidate gene for the genetic improvement of water use efficiency (WUE) and drought tolerance in breeding programs. In this study, we isolated two distinct homologues (TaER1 and TaER2) of TaER genes in common wheat through in silico screening and PCR-based homologous cloning. Sequence analysis revealed that these two genes had a similar intron/exon structure with 27 exons and 26 introns, and each of them encode a putative Leucine-rich repeat receptor-like serine/threonine protein kinase in common wheat. The coding sequence (CDS) is 2928 bp for TaER1, encoding a protein with 975 amino acid residues, and 2931 bp for TaER2 deduced to encode 976 amino acid residues, and their corresponding genomic DNA sequences are 6858 bp and 7114 bp, respectively. Cloning and sequencing of 55 TaER cDNA clones revealed five transcript variants of TaER1 and nine spliced isoforms of TaER2, designated as TaER1.1 to TaER1.5 and TaER2.1 to TaER2.9 respectively. Genome specific primers were designed based on the sequence divergence of the promoter regions between the two homologous genes. PCR amplification from genomic DNA of Chinese Spring (CS) nullisomic-tetrasomic lines revealed that TaER1 and TaER2 were located on chromosomes 7D and 7B in common wheat, respectively. TaER1 and TaER2 have therefore been renamed as TaER-D1 (GeneBank accession: JQ599260.2) and TaER-B1 (GeneBank accession: JQ599261.2) respectively. Real-time quantitative RT-PCR analysis showed that the TaER genes were strongly expressed in young immature tissues and organs and could be up-regulated by numerous environmental stresses, such as drought, salinity, cold stress and heat stress. This indicated that it may play significant roles in wheat growth and development and be a regulator in the response to environmental stress.
ChemInform Abstract: Asymmetric Strecker Synthesis Using Enantiopure Sulfinimines and Diethylaluminum Cyanide: The Alcohol Effect. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Outcome of Deferred Initial Therapy in Mantle-Cell Lymphoma (2009)

In selected asymptomatic patients with MCL, deferred initial treatment ("watch and wait") is an acceptable management approach.