gebhart/patrepeval huggingface dataset:
842 ADMINISTRATION OF A UNIQUE RENOPROTECTIVE COCKTAIL IN A RAT MODEL: CAN WARM ISCHEMIA-REPERFUSION INJURY BE PREVENTED? (2012)

You have accessJournal of UrologyTechnology & Instruments: Laparoscopy - Malignant Disease1 Apr 2012842 ADMINISTRATION OF A UNIQUE RENOPROTECTIVE COCKTAIL IN A RAT MODEL: CAN WARM ISCHEMIA-REPERFUSION INJURY BE PREVENTED? Andrew I. Fishman, Thambi Dorai, Jacob Cohen, David S. Goldfarb, and Michael Grasso Andrew I. FishmanAndrew I. Fishman Valhalla, NY More articles by this author , Thambi DoraiThambi Dorai Valhalla, NY More articles by this author , Jacob CohenJacob Cohen Valhalla, NY More articles by this author , David S. GoldfarbDavid S. Goldfarb New York, NY More articles by this author , and Michael GrassoMichael Grasso Valhalla, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.934AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Extended warm ischemia time greater than 30 minutes during laparoscopic partial nephrectomy can lead to considerable renal injury and continues to be a limiting factor in performing larger, more complex partial nephrectomies. Using a rat model of renal ischemia, we examined the ability of a unique renoprotective cocktail to mitigate or prevent warm ischemia-reperfusion injury. METHODS A warm renal ischemia model was developed using 60 Sprague–Dawley rats. The left renal hilum was clamped for 40 minutes, followed by 48 hours of reperfusion. A renoprotective cocktai, referred to as GPM; a mixture of specific growth factors, mitochondria protecting biochemicals and Manganese-Porphyrin (MnTnHex-2-PYP5+) was given intramuscularly at -24, 0, and 24 hours after surgery. At 48 hours, the 2 kidneys were harvested and examined with hematoxylin and eosin and periodic acid-Schiff stains. Protein and gene expression were analyzed to determine ischemia markers and the antioxidant response. RESULTS Compared to ischemic controls, kidneys treated with the renoprotective cocktail showed significant reversal of morphological changes (Figure 1) and a significant decrease in the specific ischemic markers lipocalin-2, Mucin-1 and galectin-3. Quantitative reverse transcriptase-polymerase chain reaction revealed up-regulation of several antioxidant genes in treated animals. CONCLUSIONS According to histopathologic and several molecular measures our unique renoprotective cocktail mitigated ischemia-reperfusion injury in an animal model. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187 Issue 4S April 2012 Page: e343 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.Metrics Author Information Andrew I. Fishman Valhalla, NY More articles by this author Thambi Dorai Valhalla, NY More articles by this author Jacob Cohen Valhalla, NY More articles by this author David S. Goldfarb New York, NY More articles by this author Michael Grasso Valhalla, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
Evaluation of Germline Genetic Testing Criteria in a Hospital-Based Series of Women With Breast Cancer (2020)

A substantial proportion of women with breast cancer carrying germline pathogenic variants in predisposition genes do not qualify for testing by NCCN criteria. Expansion of NCCN criteria to include all women diagnosed at ≤ 65 years of age improves the sensitivity of the selection criteria without requiring testing of all women with breast cancer.
A nanoemulsion of an anti-oxidant synergy formulation reduces tumor growth rate in neuroblastoma-bearing nude mice. (2007)

Neuroblastoma, the most common form of childhood cancer, may arise from a biochemical block of cellular differentiation and a resultant continuation of a proliferative state. Neuroblastoma often spontaneously reverts by undergoing partial differentiation and ultimate degeneration and may be associated with the generation of reactive oxygen species (ROS). We have recently reported in neuroblastoma cell culture studies that an anti-oxidant synergy formulation (ASF) can induce differentiation and buffer neuronal degeneration and oxidative stress in cultured cortical neurons and in central nervous system tissue of apolipoprotein E-deficient mice. The objective of the present study was to investigate whether a subcutaneous injection and/or transdermal application of a nanoemulsion preparation of ASF would reduce tumor growth rate in a neuroblastoma xenograph mouse model. The results indicate that whereas suspensions of ASF were ineffective in decreasing tumor growth rate in the neuroblastoma mouse model, tumor growth rate was similarly reduced an average 65% by either subcutaneous injection or transdermal application of an ASF nanoemulsion preparation to the tumor. In conclusion, the data suggest that subcutaneous and/or transdermal application of an ASF nanoemulsion preparation is effective in reducing tumor growth rate in this neuroblastoma mouse model.
Characterization of Mannuronan C-5-Epimerase Genes from the Brown Alga <i>Laminaria digitata</i>  (2003)

Alginate is an industrially important polysaccharide obtained commercially by harvesting brown algae. The final step in alginate biosynthesis, the epimerization of beta-1,4-d-mannuronic acid to alpha-1,4-l-guluronic acid, a structural change that controls the physicochemical properties of the alginate, is catalyzed by the enzyme mannuronan C-5-epimerase. Six different cDNAs with homology to bacterial mannuronan C-5-epimerases were isolated from the brown alga Laminaria digitata (Phaeophyceae). Hydrophobic cluster analysis indicated that the proteins encoded by the L. digitata sequences have important structural similarities to the bacterial mannuronan C-5-epimerases, including conservation of the catalytic site. The expression of the C-5-epimerase genes was examined by northern-blot analysis and reverse transcriptase-polymerase chain reaction in L. digitata throughout a year. Expression was also monitored in protoplast cultures by northern and western blot, reverse transcriptase-polymerase chain reaction, and activity measurements. From both the structural comparisons and the expression pattern, it appears that the cDNAs isolated from L. digitata encode functional mannuronan C-5-epimerases. The phylogenetic relationships of the bacterial and brown algal enzymes and the inferences on the origin of alginate biosynthetic machinery are discussed.
Performance Modeling of Diversity Coded Path Protection in OBS/OPS Networks (2019)

In bufferless optical burst/packet switched (OBS/OPS) networks, data (bursts or packets) may be lost due to contention or equipment failure. Diversity coding-based path protection schemes can be used to protect data from a single-trunk failure with potentially more efficient resource utilization compared to dedicated (e.g., 1 + 1) path protection schemes and help reduce the burst/packet loss ratio. This paper provides a scalable and accurate burst/packet loss ratio approximation based on the Erlang fixed-point approximation for networks that employ protection based on diversity coding and for networks that employ protection based on both diversity coding and 1 + 1 path protection. We use discrete event simulations to assess the accuracy of the approximation based on a wide range of scenarios in a 10-node circular lattice and NSFNet networks. Further, we discuss the effect of parameter settings and the effect of the choice of the wavelength selection method on the accuracy of the approximation. We consider scenarios without wavelength conversion and with full wavelength conversion and two types of users: premium and regular. The premium users, typically of mission critical services, receive protection while the regular users do not. We compare diversity coding and 1 + 1 path protection in a 10-node circular lattice network. The results show that for this example network, for the premium users and under low traffic load, the burst/packet loss ratio in OBS/OPS networks is lower for diversity coding compared to 1 + 1 path protection. However, under heavy traffic load, we observe a lower loss ratio for the case of 1 + 1 path protection.
Aerosolized Surfactant Improves Pulmonary Function in Endotoxin-induced Lung Injury (1998)

Surfactant dysfunction is a primary pathophysiologic component in patients with adult respiratory distress syndrome (ARDS). In this study we tested the efficacy of aerosolized surfactant (Sf ) replacement in a severe lung injury model of endotoxin-induced ARDS. Twenty-one certified healthy pigs were anesthetized, surgically prepared for measurement of hemodynamic and lung function, then randomized into one of four groups: (1) control (n = 5), surgical instrumentation only; (2) lipopolysaccharide (LPS) (n = 6), infused with Escherichia coli LPS (100 microgram/kg) without positive end- expiratory pressure (PEEP) and ventilated with a nonhumidified gas mixture of 50% N2O and 50% O2; (3) LPS + PEEP (n = 4), infused with LPS, placed on PEEP (7.5 cm H2O), and ventilated with a humidified gas mixture; and (4) LPS + PEEP + Sf (n = 6), infused with LPS, placed on PEEP, and ventilated with aerosolized Sf (Infasurf, ONY, Inc.). All animals were studied for 6 h. Arterial PO2 significantly decreased in both the LPS and LPS + PEEP groups (LPS + PEEP = 74 +/- 19 mm Hg; LPS = 74 +/- 19 mm Hg, p < 0.05) while venous admixture (Q S/Q T) increased in these groups (LPS + PEEP = 43.3 +/- 3.9%; LPS = 47.7 +/- 11%, p < 0.05) as compared with the control group. PEEP + Sf reduced the fall in PO2 (142 +/- 20 mm Hg) and rise in Q S/Q T (15.1 +/- 3.6%) caused by LPS. Delayed induction of PEEP (2 h following LPS) did not significantly improve any parameter over the LPS group without PEEP in this ARDS model. LPS without PEEP (3.4 +/- 0.2 cells/6,400 micrometer2) caused a marked increase in the total number of sequestered leukocytes in the pulmonary parenchyma as compared with the control group (1.3 +/- 0.1 cells/6,400 micrometer2). LPS + PEEP + Sf (2.3 +/- 0.2 cells/6,400 micrometer2) significantly decreased while LPS + PEEP significantly increased (4.0 +/- 0.2 cells/6,400 micrometer2) the total number of sequestered leukocytes as compared with the LPS without PEEP group. In summary, aerosolized surfactant replacement decreased leukocyte sequestration and improved oxygenation in our porcine model of endotoxin-induced lung injury.
Unveiling the Structure of Polytetraruthenated Nickel Porphyrin by Raman Spectroelectrochemistry (2015)

The structure of polytetraruthenated nickel porphyrin was unveiled for the first time by electrochemistry, Raman spectroelectrochemistry, and a hydroxyl radical trapping assay. The electrocatalytic active material, precipitated on the electrode surface after successive cycling of [NiTPyP{Ru(bipy)2Cl}4](4+) species in strong aqueous alkaline solution (pH 13), was found to be a peroxo-bridged coordination polymer. The electropolymerization process involves hydroxyl radicals (as confirmed by the characteristic set of DMPO/(•)OH adduct EPR peaks) as reaction intermediates, electrocatalytically generated in the 0.80-1.10 V range, that induce the formation of Ni-O-O-Ni coordination polymers, as evidenced by Raman spectroelectrochemistry and molecular modeling studies. The film growth is halted above 1.10 V due to the formation of oxygen gas bubbles.
Anterior Plate Instrumentation for Disorders of the Subaxial Cervical Spine (1997)

Anterior cervical plate instrumentation is useful in the maintenance of cervical alignment, the prevention of graft extrusion, and the development of late deformity as well as potentially avoiding the need for a secondary posterior cervical procedure in the setting of cervical trauma. Its role in cervical reconstruction after decompression for cervical spondylosis is evolving. The definite risks of anterior cervical instrumentation should be considered, that is, screw and plate displacement or screw violation of neurologic structures, before the implementation of this form of fixation.
Investigation of thermal and fluidic losses and their effect on the performances of a Stirling refrigerator - Influence des pertes thermiques et fluidiques sur les performances d’un réfrigérateur Stirling Résumé (2021)

International audience
Formation of an amorphous phase and its crystallization in the immiscible Nb–Zr system by mechanical alloying (2013)

Mechanical alloying of binary Nb-Zr powder mixtures was carried out to evaluate the formation of metastable phases in this immiscible system. The milled powders were characterized for their constitution and structure by X-ray diffraction and transmission electron microscopy methods. It was shown that an amorphous phase had formed on milling the binary powder mixture for about 10 h and that it had crystallized on subsequent milling up to 50–70 h, referred to as mechanical crystallization. Thermodynamic and structural arguments have been presented to explain the formation of the amorphous phase and its subsequent crystallization.
Commentary on Secondary Fracture Prevention: Consensus Clinical Recommendations From a Multistakeholder Coalition Originally Published in the Journal of Bone and Mineral Research (2020)

aDepartment of Orthopaedic Surgery, Virginia Commonwealth University, Richmond, VA bBoston University Medical Center, Boston, MA The authors report no conflict of interest.
Enzymatic Hydrolysis Combined with Mechanical Shearing and High-Pressure Homogenization for Nanoscale Cellulose Fibrils and Strong Gels (2007)

Toward exploiting the attractive mechanical properties of cellulose I nanoelements, a novel route is demonstrated, which combines enzymatic hydrolysis and mechanical shearing. Previously, an aggressive acid hydrolysis and sonication of cellulose I containing fibers was shown to lead to a network of weakly hydrogen-bonded rodlike cellulose elements typically with a low aspect ratio. On the other hand, high mechanical shearing resulted in longer and entangled nanoscale cellulose elements leading to stronger networks and gels. Nevertheless, a widespread use of the latter concept has been hindered because of lack of feasible methods of preparation, suggesting a combination of mild hydrolysis and shearing to disintegrate cellulose I containing fibers into high aspect ratio cellulose I nanoscale elements. In this work, mild enzymatic hydrolysis has been introduced and combined with mechanical shearing and a high-pressure homogenization, leading to a controlled fibrillation down to nanoscale and a network of long and highly entangled cellulose I elements. The resulting strong aqueous gels exhibit more than 5 orders of magnitude tunable storage modulus G' upon changing the concentration. Cryotransmission electron microscopy, atomic force microscopy, and cross-polarization/magic-angle spinning (CP/MAS) 13C NMR suggest that the cellulose I structural elements obtained are dominated by two fractions, one with lateral dimension of 5-6 nm and one with lateral dimensions of about 10-20 nm. The thicker diameter regions may act as the junction zones for the networks. The resulting material will herein be referred to as MFC (microfibrillated cellulose). Dynamical rheology showed that the aqueous suspensions behaved as gels in the whole investigated concentration range 0.125-5.9% w/w, G' ranging from 1.5 Pa to 105 Pa. The maximum G' was high, about 2 orders of magnitude larger than typically observed for the corresponding nonentangled low aspect ratio cellulose I gels, and G' scales with concentration with the power of approximately three. The described preparation method of MFC allows control over the final properties that opens novel applications in materials science, for example, as reinforcement in composites and as templates for surface modification.
Elevated levels of substance P in tears of patients with allergic conjunctivitis and vernal keratoconjunctivitis (1997)

This study suggests that the increased level of SP in tears may contribute to the pathogenesis and severity of ocular allergic diseases.
Fraction of stars in clusters for the LEGUS dwarf galaxies (2022)

ABSTRACT We study the young star cluster populations in 23 dwarf and irregular galaxies observed by the Hubble Space Telescope (HST) Legacy ExtraGalactic Ultraviolet Survey (LEGUS), and examine relationships between the ensemble properties of the cluster populations and those of their host galaxies: star formation rate (SFR) density (ΣSFR). A strength of this analysis is the availability of SFRs measured from temporally resolved star formation histories that provide the means to match cluster and host galaxy properties on several time-scales (1–10, 1–100, and 10–100 Myr). Nevertheless, studies of this kind are challenging for dwarf galaxies due to the small numbers of clusters in each system. We mitigate these issues by combining the clusters across different galaxies with similar ΣSFR properties. We find good agreement with a well-established relationship ($M_{V}^{\mathrm{ brightest}}$–SFR), but find no significant correlations between ΣSFR and the slopes of the cluster luminosity function, mass function, nor the age distribution. We also find no significant trend between the fraction of stars in bound clusters at different age ranges (Γ1–10, Γ10–100, and Γ1–100) and ΣSFR of the host galaxy. Our data show a decrease in Γ over time (from 1–10 to 10–100 Myr) suggesting early cluster dissolution, though the presence of unbound clusters in the youngest time bin makes it difficult to quantify the degree of dissolution. While our data do not exhibit strong correlations between ΣSFR and ensemble cluster properties, we cannot rule out that a weak trend might exist given the relatively large uncertainties due to low number statistics and the limited ΣSFR range probed.
Emulating human attention-getting practices with wearable haptics (2010)

Our computers often need to get our attention, but have inadequate means of modulating the intrusiveness with which they do so. Humans commonly use social touch to gain one another's attention. In this paper, we describe an early exploration of how an expressive, wearable or holdable haptic display could emulate human social practices with the goal of evoking comparable responses from users. It spans three iterations of rapid prototyping and user evaluation, beginning with broad-ranging physical brainstorming, before proceeding to higher-fidelity actuated prototypes. User reactions were incorporated along the way, including an assessment of the low-fidelity prototypes' expressiveness. Our observations suggest that, using simple and potentially unintrusive body-situated mechanisms like a bracelet, it is possible to convey a range of socially gradable attention-getting expressions to be useful in real contexts.
ChemInform Abstract: Radical Cyclization Strategies for the Formation of Ring Constrained Tricyclic Tropane Analogues. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Introduction to Polyspectral Modeling and Compensation Techniques for Wideband Communications Systems (2001)

The requirements/environments for broadband commercial and military communication systems have focused attention on the issues of efficiency and nonlinearity characterization of power amplifiers, and the mitigation of the distortion they produce. Common system modeling approaches, which are dominated by probing signals of at most a multi-tone nature, prove to be inadequate for representing channels with operational bandwidths reaching the multi-GHz range. This shortfall in modeling fidelity is especially the case for higher-order, non-constant envelope modulations that are often needed to meet bandwidth efficiency demands. As a natural consequence, distortion compensation designs based on these models will likewise prove to be less than optimal in their effectiveness. This paper introduces an established nonlinear system identification technique from the mechanical systems field that essentially solves the wideband modeling problem, and in addition provides very unique assessment and design tools for distortion compensation. The technique is a special case of a formal operator series representation for the given nonlinearity with memory, and its construction is based on an extremely accurate baseband time-domain measurement technique-using pseudo-randomly modulated signals - that will also be described. The basic modeling and compensation features of the method will then be provided, followed by two representative high-power amplifier (HPA) applications to illustrate and validate the modeling method. The fidelity evaluation will be performed in the time-domain using a normalized mean-square error (NMSE) waveform metric, and compared with results found for standard block model approaches.
Deterministic and stochastic coarsening control in optically addressed spatial light modulators subject to optical feedback (2023)

Phase separation accompanied by domain growth and coarsening is a phenomenon common to a broad variety of dynamical systems. In this context, controlling such processes represents a relevant interdisciplinary problem. Through numerical modeling, we demonstrate two complementary approaches of coarsening control in bistable systems based on the example of a spatially extended model describing an optically addressed spatial light modulator with two-color illumination subject to optical feedback. The first method implies varying system parameters such that the system evolves as the pitchfork or saddle-node normal forms. The second method leverages noise, whose intensity serves as an additional system control parameter. Both deterministic and stochastic schemes allow us to control the direction and speed of the fronts separating spatial domains. The considered stochastic control represents a particular case of noise-sustained front propagation in bistable systems and involves the properties of the optical system under study. In contrast, the proposed deterministic control technique can generally be applied to bistable systems of different natures.
Instantaneous Frequency Measurement (IFM) Receivers (2005)

In this chapter, the operating principles of IFM receivers, some trade-offs in the designs, and several schemes for digitizing the outputs of the video amplitude will be discussed. Since an IFM receiver can measure only one input signal at a time, one continuous-wave (CW) signal will block the receiver from measuring other input signals. This CW problem will be discussed. The overlapping signal problem and some schemes to detect the existence of overlapping signals will also be discussed.
ONE-TO-ONE GENE-ENCODED FUNCTIONAL PROTEIN MICROARRAY (2008)

We report an on-chip platform technology for creating a high-density single molecule-derived protein array. We previously developed a nanobio device that is a microfabricated chip, comprised of uniformly distributed sub-picoliter scale reactors of one million microreactor chambers and a multipoint automatic detection system using a CCD-based image intensifier, as a powerful tool to directly image single biomolecule fluorescence. Here we use this device for on-chip synthesis of protein arrays, and demonstrate a novel approach to attach single DNA/mRNA molecule derived arrays on the surface of the chip. We produce and link the encoded proteins directly from the pre-arrayed DNA/mRNA using a cell-free gene expression system.