gebhart/patrepeval huggingface dataset:
Luciferase Controlled Protein Interactions (2021)

Protein trafficking and protein-protein interactions (PPIs) are central to regulatory processes in cells. Induced dimerization systems have been developed to control PPIs and regulate protein trafficking (localization) or interactions. Chemically induced dimerization (CID) has proven to be a robust approach to control protein interactions and localization. The most recent embodiment of this technology relies on CID conjugates that react with a self-labeling protein on one side and a photocaged ligand on the other side to provide spatiotemporal control of the interaction with the protein of interest. Advancing this technology further is limited by the light delivery problem and the phototoxicity of intense irradiation necessary to achieve photouncaging. Herein, we designed a novel chemically induced dimerization system that was triggered by bioluminescence, instead of external light. Protein dimerization showed fast kinetics and was validated by an induced change of localization of a target protein (to and from the nucleus or plasma membrane) upon trigger. The technology was used transiently to activate the phosphatidylinositol 3-kinase (PI3K)/mTOR pathway and measure the impact on lipid synthesis/metabolism, assessed by lipidomics.
Imaging of spherical objects in a reflecting acoustic microscope (1993)

An expression is derived for the output signal of a reflecting acoustic microscope in scanning of a spherical object. It is shown that the character of the image of such an object depends significantly on the position of the focal plane relative to the center of curvature of the sphere. The experimental results are in good agreement with the theory.
Early relapse of JAK2 V617F‐positive chronic neutrophilic leukemia with central nervous system infiltration after unrelated bone marrow transplantation (2006)

Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative disorder characterized by a proliferation mainly of mature neutrophils. The prognosis is generally poor and an optimal therapeutic strategy remains to be determined. Allogeneic hematopoietic stem cell transplantation (HSCT) is expected to be the only curative therapy so far. We report a 46-year-old male with progressive CNL who underwent bone marrow transplantation from an HLA-matched unrelated donor. After engraftment was achieved on day 35, relapse of CNL was confirmed on day 50. The progression of CNL was very rapid afterward and infiltration to the central nervous system was observed. The Janus Kinase 2 (JAK2) V617F homozygous mutation was detected from the peripheral blood or bone marrow samples throughout the clinical course. From comparison with reports of successful HSCT for CNL in the literature, it was inferred that HSCT should be performed in a stable status before progression. Furthermore, JAK2 V617F-positive CNL may contain an aggressive disease entity in contrast to previous reports. Accumulation of experiences is required to establish a definite role of HSCT in the treatment of CNL and a prognostic significance of JAK2 mutation in CNL.
Change in Catalytic Property of Trypsin Immobilized on Support Activated with Glutaraldehyde in Lower Protogenic Solvent. (1999)

A variety of glutaraldehyde (GA) activated-aminopropyl controlled pore glass supports were prepared in lower protogenic solvents (methanol, ethanol, and n-propanol). When trypsin was used as the ligand, the amount of trypsin immobilized on them decreased in the order of water, methanol, ethanol, and n-propanol; the maximal reduction of 22% was observed in n-propanol versus that in water. The Michaelis constants of the trypsins immobilized on the support activated with GA in alcohols, especially ethanol and propanol, were smaller than that in water, and the minimum K m value of 1.84×10-1 mM was obtained in propanol (4.29×10-1 mM in water). During the reaction of GA with 2-aminoethanol, the amount of the aldehyde group from GA being capable of reacting with 2-aminoethanol significantly decreased when the reaction was done in n-propanol (0.18 mmol/assay volume, cf. in water; 0.35 mmol/assay volume). The gel permeation chromatography (GPC) measurement of the GA complex, glycine-GA-phenetylamine, also revealed the suppression of the GA self-polymerization in the lower protogenic alcohol as a support activating solvent.
Un procédé de contrôle de débit pour la transmission de vidéo MPEG-4 sur l'internet (1999)

Resume ‐ Les flux multimedia transmis a l’heure actuelle dans l’Internet sont depourvus de m ecanisme de controle de congestion. Ceci pose probleme, car l’un des principes fondateurs des reseaux IP, en terme de gestion de trafic, donne aux applications la responsabi lite de ce controle. En son absence, les phenomenes de congestion, induisant pertes de donnees et delais accrus, degradent considerablement tous les trafics circulant dans le reseau, et peuvent conduire a un ecroulement de ce dernier. La presente etude se focalise sur un proc ede de transmission de video MPEG-4 qui integre un controle de congestion adapte au flux video et capable de cohabiter avec les commun ications teleinformatiques classiques. Elle met en evidence les avantages qui decoulent d’une telle approche, non seulement pour le rese au mais aussi pour la session de transmission de video, qui voit la qualite finale du flux accrue.
Evaluation of four mammographic density measures on HRT data (2007)

Numerous studies have investigated the relation between mammographic density and breast cancer risk. These studies indicate that women with dense breasts have a four to six fold risk increase. There is currently no gold standard for automatic assessment of mammographic density. In previous work two different automated methods for measuring the effect of HRT w.r.t. changes in breast density have been presented. One is a percentage density based on an adaptive global threshold, and the other is an intensity invariant measure, which provides structural information orthogonal to intensity-based methods. In this article we investigate the ability to detect density changes induced by HRT for these measures and compare to a radiologist's BI-RADS rating and interactive threshold percentage density. In the experiments, two sets of mammograms of 80 patients from a double blind, placebo controlled HRT experiment are used. The p-values for the statistical significance of the separation of density means, for the HRT group and the placebo group at end of study, are 0.2, 0.1, 0.02 and 0.02 for the automatic threshold, BI-RADS, the stripyness and the interactive threshold respectively.
Fisiologia da planta de sorgo. (2000)

Estadios de desenvolvimento do sorgo; Altura da planta e desenvolvimento inicial das folhas; Perfilhamento; Sistema radicular; Desenvolvimento da parte aerea; Florescimento; Aspectos gerais dos efeitos ambientais sobre o crescimento do sorgo; Acumulacao de materia seca e producao; Rebrota; Tanino no grao de sorgo; Tolerancia de plantas a estresses ambientais; Tolerancia aos solos acidos.
[Metapsychological considerations on the model of attachment of J. Bowlby]. (1991)

J. Bowlby's thought may be divided into two different aspects. The first one, which has had a fertile function in the history of psychoanalysis, emphasizes the influence of the real environment on the infant development and, furthermore, it shows that the infant attachment to the mother is based on a mutual instinctive behaviour, rather than on the oral drive. The second aspect concerns the construction of a new theory radically conflicting with metapsychology. Indeed, as Bowlby demonstrates, the latter is based on concepts (e.g. drive) incompatible with contemporary biology. Nevertheless, I think that these concepts have been misunderstood and that metapsychology is still unreplaceable, although it needs further developments. For instance, the possibility to base primitive (pre-object, pre-representational, pre-drive) relationship on metapsychology, preserving the economic viewpoint, may be examined carefully.
Demonstration of Broadband Space-Time Wave-Packets Propagating 70 m (2019)

We demonstrate experimentally the synthesis of broadband space-time light sheets of width ≈ 700 µm and bandwidth ∼20 nm propagating spectral ≈ 70 m in free-space, through introducing tight spatio-temporal correlations.
Translesion DNA synthesis-driven mutagenesis in very early embryogenesis of fast cleaving embryos (2021)

In early embryogenesis of fast cleaving embryos DNA synthesis is short and surveillance mechanisms preserving genome integrity are inefficient implying the possible generation of mutations. We have analyzed mutagenesis in <em>Xenopus laevis</em> and <em>Drosophila melanogaster</em> early embryos. We report the occurrence of a high mutation rate in <em>Xenopus</em> and show that it is dependent upon the translesion DNA synthesis (TLS) master regulator Rad18. Unexpectedly, we observed a homology-directed repair contribution of Rad18 in reducing the mutation load. Genetic invalidation of TLS in the pre-blastoderm <em>Drosophila</em> embryo resulted in reduction of both the hatching rate and Single Nucleotide Variations on specific chromosome regions in adult flies. Altogether, these findings indicate that during very early <em>Xenopus</em> and <em>Drosophila</em> embryos TLS strongly contributes to the high mutation rate. This may constitute a previously unforeseen source of genetic diversity contributing to the polymorphisms of each individual with implications for genome evolution and species adaptation.<br>
Malignant Lymphoma of the Testis: Histological and Immunohistological Study of 28 Cases (1989)

Histological and immunohistological studies were made in 28 patients with testicular lymphoma who presented with a right (15), left (11) or bilateral (2) scrotal swelling. Patient age at hospitalization ranged from 39 to 87 years, with a median age of 64 years. The disease was stage 1 in 12 patients, stage 2 in 11 and stage 3 in 5. Histologically, most of the neoplasms were of the diffuse large cell type, with an immunoblastic type being the most common. Immunohistochemistry revealed that all but 2 cases were of the B cell type. None of the tumors reacted with monoclonal antibody for T cell. These findings suggested that testicular lymphoma exclusively consisted of the B cell type, identical to previous reports of extranodal lymphomas other than those in the skin. The pertinent literature is reviewed and the histogenesis of testicular lymphoma is discussed.
An efficient continuous flow approach to furnish furan-based biaryls (2014)

Suzuki cross-couplings of 5-formyl-2-furanylboronic acid with activated or neutral aryl bromides were performed under continuous flow conditions in the presence of (Bu)4N(+)F(-) and the immobilised t-butyl based palladium catalyst CatCart™ FC1032™. Deactivated aryl bromides and activated aryl chlorides were cross-coupled with 5-formyl-2-furanylboronic in the presence of (Bu)4N(+)OAc(-) using the bis-triphenylphosphine CatCart™ PdCl2(PPh3)2-DVB. Initial evidence indicates the latter method may serve as a universal approach to conduct Suzuki cross-couplings with the protocol successfully employed in the synthesis of the current gold standard Hedgehog pathway inhibitor LDE225.
Is Parallel Programming Hard, And, If So, What Can You Do About It? (Release v2023.06.11a) (2017)

The purpose of this book is to help you program shared-memory parallel systems without risking your sanity. Nevertheless, you should think of the information in this book as a foundation on which to build, rather than as a completed cathedral. Your mission, if you choose to accept, is to help make further progress in the exciting field of parallel programming-progress that will in time render this book obsolete. Parallel programming in the 21st century is no longer focused solely on science, research, and grand-challenge projects. And this is all to the good, because it means that parallel programming is becoming an engineering discipline. Therefore, as befits an engineering discipline, this book examines specific parallel-programming tasks and describes how to approach them. In some surprisingly common cases, these tasks can be automated. This book is written in the hope that presenting the engineering discipline underlying successful parallel-programming projects will free a new generation of parallel hackers from the need to slowly and painstakingly reinvent old wheels, enabling them to instead focus their energy and creativity on new frontiers. However, what you get from this book will be determined by what you put into it. It is hoped that simply reading this book will be helpful, and that working the Quick Quizzes will be even more helpful. However, the best results come from applying the techniques taught in this book to real-life problems. As always, practice makes perfect. But no matter how you approach it, we sincerely hope that parallel programming brings you at least as much fun, excitement, and challenge that it has brought to us!
Cumulative effect of complete left bundle-branch block and chronic atrial fibrillation on 1-year mortality and hospitalization in patients with congestive heart failure. A report from the Italian network on congestive heart failure (in-CHF database) (2002)

In patients with congestive heart failure, the contemporary presence of left bundle-branch block and atrial fibrillation was associated with a significant increase in mortality. This synergistic effect remained significant after adjusting for clinical variables usually associated with advanced heart failure. We can conclude that this combination of electrical disturbances identifies a congestive heart failure specific population with a high risk of mortality.
Supplementary Data from Development of Immunohistochemistry Assays to Assess GALNT14 and FUT3/6 in Clinical Trials of Dulanermin and Drozitumab (2023)

Supplementary Data from Development of Immunohistochemistry Assays to Assess GALNT14 and FUT3/6 in Clinical Trials of Dulanermin and Drozitumab
Channel Hardening in Massive MIMO-A Measurement Based Analysis (2018)

Wireless-controlled robots, cars and other critical applications are in need of technologies that offer high reliability and low latency. Massive MIMO, Multiple-Input Multiple-Output, is a key technology for the upcoming 5G systems and is one part of the solution to increase the reliability of wireless systems. More specifically, when increasing the number of base station antennas in a massive MIMO systems the channel variations decrease and the so-called channel hardening effect appears. This means that the variations of the channel gain in time and frequency decrease. In this paper, channel hardening in massive MIMO systems is assessed based on analysis of measurement data. For an indoor scenario, the channels are measured with a 128-port cylindrical array for nine single-antenna users. The analysis shows that in a real scenario a channel hardening of 3.2-4.6 dB, measured as a reduction of the standard deviation of the channel gain, can be expected depending on the amount of user interaction. Also, some practical implications and insights are presented.
Up-converted emission observed from hybrid inorganic:organic composite thin film generated via laser-assisted molecular beam deposition (2000)

Laser Assisted Molecular Beam Deposition (LAMBD) is a pulsed laser ablation technique which utilizes a train of gas pulses to precisely control the chemistry and transport of species to be deposited on a substrate. The LAMBD technique has been used to grow films on a variety of substrates and to ablate a variety of target materials including: metals, metal oxides, metal halides, Si, C and SiC. In addition, a variety of more complex composite films such as Cu embedded polymers, Yba<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7-x</SUB> and organic doped TiO<SUB>2</SUB> and Al<SUB>2</SUB>O<SUB>3</SUB> have also been produced. These films have been analyzed by Raman scattering, SEM, EDX, FTIR, ESCA, NMR, mass spectrometry surface profile measurements to determine film structure and composition. Recently a successful program has been undertaken to show the potential of LAMBD to generate photonic films. Work done on up-conversion of IR light into the visible using LAMBD generated composite TiO<SUB>2</SUB>:APSS films will be described. These results demonstrate the potential of using LAMBD sources as a means of depositing a variety of high quality photonic films.
Supplementary Data from Targeted Knockdown of &lt;i&gt;Notch1&lt;/i&gt; Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator (2023)

Supplementary Data from Targeted Knockdown of &lt;i&gt;Notch1&lt;/i&gt; Inhibits Invasion of Human Prostate Cancer Cells Concomitant with Inhibition of Matrix Metalloproteinase-9 and Urokinase Plasminogen Activator
Dichoptic Multifocal Pupillography Reveals Afferent Visual Field Defects in Early Type 2 Diabetes (2010)

Reasonable diagnostic power was obtained, especially for the 16 eyes that had had T2D for more than 10 years, inferring that even in the near absence of visible diabetic retinopathy, some retinal damage had been sustained. This result, if confirmed in a wider group, suggests the that the method may be clinically useful in screening for early damage to the retina in T2D diabetes.
Data from Identification and Therapeutic Targeting of GPR20, Selectively Expressed in Gastrointestinal Stromal Tumors, with DS-6157a, a First-in-Class Antibody–Drug Conjugate (2023)

&lt;div&gt;Abstract&lt;p&gt;Currently, the only approved treatments for gastrointestinal stromal tumor (GIST) are tyrosine kinase inhibitors (TKI), which eventually lead to the development of secondary resistance mutations in KIT or PDGFRA and disease progression. Herein, we identified G protein–coupled receptor 20 (GPR20) as a novel non–tyrosine kinase target in GIST, developed new GPR20 IHC, and assessed GPR20 expression in cell lines, patient-derived xenografts, and clinical samples from two institutes (United States and Japan). We studied GPR20 expression stratified by treatment line, KIT expression, GIST molecular subtype, and primary tumor location. We produced DS-6157a, an anti-GPR20 antibody–drug conjugate with a novel tetrapeptide-based linker and DNA topoisomerase I inhibitor exatecan derivative (DXd). DS-6157a exhibited GPR20 expression–dependent antitumor activity in GIST xenograft models including a GIST model resistant to imatinib, sunitinib, and regorafenib. Preclinical pharmacokinetics and safety profile of DS-6157a support its clinical development as a potential novel GIST therapy in patients who are refractory or have resistance or intolerance to approved TKIs.&lt;/p&gt;Significance:&lt;p&gt;GPR20 is selectively expressed in GIST across all treatment lines, regardless of &lt;i&gt;KIT&lt;/i&gt;/&lt;i&gt;PDGFRA&lt;/i&gt; genotypes. We generated DS-6157a, a DXd-based antibody–drug conjugate that exhibited antitumor activity in GIST models by a different mode of action than currently approved TKIs, showing favorable pharmacokinetics and safety profiles.&lt;/p&gt;&lt;p&gt;&lt;i&gt;This article is highlighted in the In This Issue feature, p. 1307&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Sensitivity Testing of Contaminated Surfaces to Establish Nonreactivity Levels at Energetic Processing Facilities (2004)

Abstract : The downsizing and closing of military facilities have generated the need to eliminate potential explosive hazards from facilities previously used to process energetic materials. Testing for contamination levels of such hazards is an established practice; however, there are no established criteria for determining safe levels of the contamination. Small-scale sensitivity testing was performed to establish levels of contamination that would not exhibit reactions to normally executed construction practices, such as equipment installation and facility remodeling. Standard friction, impact, and electrostatic discharge (ESD) sensitivity tests were selected as appropriate to duplicate stimuli created by construction or remodeling operations. Wood, concrete, a transite simulant, and metal anvils and plates were prepared for use in standardized small-scale sensitivity testing equipment. The materials were coated with a quantifiable amount of contaminant on the testing surface. The materials were then subjected to impact, friction, and ESD sensitivity testing and observed for reactions.
Redundancy-Based Visual Tool Center Point Pose Estimation for Long-Reach Manipulators (2020)

In this paper, we study a visual sensing scheme for 6 degree-of-freedom (DOF) tool center point (TCP) pose estimation of large-scale, long-reach manipulators. A sensor system is proposed, designed especially for mining manipulators, comprising a stereo camera running a simultaneous localization and mapping (SLAM) algorithm near the TCP and multiple cameras that track a fiducial marker attached near the stereo camera. In essence, the TCP pose is formulated using two different routes in a co-operative (eye-in-hand/eye-to-hand) manner using data fusion, with the goal of increasing the system's fault tolerance and robustness via sensor redundancy. The system is studied in offline data analysis based on real-world measurements recorded using a hydraulic 6 DOF robotic manipulator with a 5 m reach. The SLAM pose trajectory is obtained using the open source ORB-SLAM2 Stereo algorithm, whereas marker-based tracking is realized with a high-end motion capture system. For reference measurements, the pose trajectory is also formulated using joint encoders and a kinematic model of the manipulator. Results of the 6 DOF pose estimation using the proposed sensor system are presented, with future work and key challenges also highlighted.
Venetoclax for the treatment of mantle cell lymphoma (2019)

Abstract: While the last decade has seen an explosion in improved therapies for mantle cell lymphoma (MCL), the outlook for patients with relapsed or refractory MCL (R/R MCL) remains poor, especially for those who are older with comorbidities or harbour dysfunction in the TP53 pathway. MCL is one of the B cell malignancies in which there is a high frequency of BCL2 overexpression, and the selective BCL2 inhibitor venetoclax has shown particular promise in the treatment of patients with R/R MCL. As a single agent, the drug is associated with a close to 80% response rate in early phase studies. However, secondary progression due to the development of resistance remains a limiting factor in the usefulness of this agent. Preclinical data have driven the push to combine venetoclax with other novel agents, particularly the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib. This therapeutic combination has increased the rate of complete remissions to over 60% and provides a promising route to meaningful long-term disease control with non-chemotherapy-based treatment.
FAP-α and uPA Show Different Expression Patterns in Premalignant and Malignant Esophageal Lesions (2008)

Fibroblast activation protein-alpha (FAP-alpha) and urokinase-type plasminogen activator (uPA) are serine proteases involved in cancer invasion and metastasis. The authors examined FAP-alpha and uPA expression in premalignant and malignant stages of esophageal adenocarcinoma by immunohistochemistry. Additionally, Western blotting was performed on fresh-frozen tissue samples. FAP-alpha and uPA were detected in metaplastic, dysplastic, and carcinoma cells, as well as in adjacent stroma. Stromal FAP-alpha expression was associated with depth of tumor invasion, while stromal uPA expression correlated with lymph node metastases in adenocarcinomas. Stromal uPA expression in cells with premalignant changes correlated with histological grading. Immunoblotting showed higher protease expression in carcinoma tissues than in normal esophageal epithelium. These results suggest that FAP-alpha and uPA expression in metaplastic, dysplastic, and esophageal cancer tissue is associated with neoplastic progression of esophageal lesions.