gebhart/patrepeval huggingface dataset:
Studies on homo- and copolymerizations of long-chained α-olefins over metallocene catalysts (2000)

Metallocene catalysts, viz., rac-Et(Ind)(2)ZrCl2, rac-Me2Si(Ind)(2)ZrCl2 and Ph2C(Flu)(Cp)ZrCl2, were studied in homopolymerization of 1-octadecene and the first two were used in copolymerization of ethylene with 1-octadecene. They exhibited different activities and rac-Et(Ind)(2)ZrCl2 was the most active in the homopolymerization carried out at 70 degrees C. At 30 degrees C, the activities were practically identical. In the copolymerization runs, the catalysts were similarly active, and the Et-bridged catalyst was the more active. The copolymers prepared over rac-Me2Si(Ind)(2)ZrCl2 were found to have more comonomer incorporated. The composition of copolymerization products was found (C-13-NMR) to vary with the catalyst system. DSC thermograms showed poly-1-octadecene prepared over rac-Et(Ind)(2)ZrCl2 to vary in properties with polymerization temperature (Figs. 3-5). The homopolymer prepared at 700C showed endotherms at 41 degrees C and 53 degrees C and that prepared at 30 degrees C produced one broader peak at 67 degrees C. With mc-Me2Si(Ind)(2)ZrCl2, the 70 degrees C homopolymer produced one broader peaks at 41 degrees C and 53 degrees C and the 30 degrees C homopolymer gave peaks at 7 degrees C and 67 degrees C. The two peaks in the homopolymer thermograms appear to be explicable in terms of different structural ordering in various homopolymer domains. As the comonomer concentration in the feed was increased, the molecular weight decreased and otherwise was independent of the type of the metallocene used.
Social and Linguistic Behavior and its Correlation to Trait Empathy (2016)

A growing body of research exploits social media behaviors to gauge psychological character- istics, though trait empathy has received little attention. Because of its intimate link to the abil- ity to relate to others, our research aims to predict participants’ levels of empathy, given their textual and friending behaviors on Facebook. Using Poisson regression, we compared the vari- ance explained in Davis’ Interpersonal Reactivity Index (IRI) scores on four constructs (em- pathic concern, personal distress, fantasy, perspective taking), by two classes of variables: 1) post content and 2) linguistic style. Our study lays the groundwork for a greater understanding of empathy’s role in facilitating interactions on social media.
Strong HLA‐DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients: Possible involvement of <i>c‐myc</i> suppression by interferon‐γ<i>in situ</i> (2005)

Strong HLA-DR antigen expression on cancer cells relates to better prognosis of colorectal cancer patients, although the precise mechanism is controversial. From an immunological point of view, HLA-DR antigen, induced by interferon (IFN)-gamma, is required for tumor-associated antigen recognition by CD4(+) T cells. For instance, as reported previously, the expression of HLA-DR antigen in normal colorectal epithelium immediately adjacent to cancer coincided significantly with the existence of IFN-gamma mRNA in the tissue. From another aspect, IFN-gamma has been revealed to suppress c-myc expression in vivo through a stat1-dependent mechanism, which is important for cell growth, cell cycle and chromosome instability. In the present study, strong HLA-DR-positive expression on cancer cells was significantly related to better prognosis for colorectal cancer patients. High IFN-gamma mRNA expression in situ indicated significantly less activation of c-myc mRNA expression. Further, HLA-DR antigen expression in cancer cells, as well as Dukes stages, was an independent factor for better long-term survival by multivariate analysis. Taken together, IFN-gamma, which induces HLA-DR antigens on the cell surface, also suppresses c-myc expression in situ, and is a possible non-immunological mechanism involved in the better long-term survival of colorectal cancer patients.
Supplementary Figures 1 - 2, Tables 1 - 2 from Molecular Profiling of Premalignant Lesions in Lung Squamous Cell Carcinomas Identifies Mechanisms Involved in Stepwise Carcinogenesis (2023)

&lt;p&gt;PDF file - 690KB, Supplementary Figure S1. Laser capture microdissection. Supplementary Figure S2. Experimental validation of PTBP3 expression. Supplementary Table S1. Patient demographics. List of SCC patients with their age, gender, grade of premalignant lesion, and assays performed. Supplementary Table S2. Alignment statistics. The number and percentage of reads aligning uniquely to the nuclear (autosomal and sex) or mitochondrial chromosomes, or not uniquely aligned, are shown for each sample.&lt;/p&gt;
Traffic Monitoring System for 100-Gbps Virtualized Optical Networks (2022)

We propose a system to get flow information of virtualized logical networks in support of 100-Gbps optical networks. By using packet sampling, we can create monitoring rules even when the monitoring target is unknown.
Nurses and the Genomic Revolution (2005)

Purpose : To increase nurses' genetics and genomics literacy through a series of articles focused on genomic research discoveries and their importance for nursing education, practice, policy, and research. Organizing Framework : “Genomics for Health” is one of three themes, along with genomes to biology and genomes to society, emanating from applications of the Human Genome Project (HGP). Methods : In this series of articles, nurse scientists who are experts in genetics and genomics sciences explain terminology, provide background information about the HGP, discuss clinical examples, and recommend changes in nursing practice, education, and research. Conclusions : The HGP has already led to major changes in clinical practice, research, education, and policy, and even more dramatic changes are predicted for people throughout the world. Mastering this information is necessary for nurses globally because genomic information will ultimately pervade all of health care.
Thermoreversible ionogels with tunable properties via aqueous gelation of an amphiphilic quaternary ammonium oligoether-based ionic liquid (2010)

The gelation of the amphiphilic quaternary ammonium oligoether-based ionic liquid (AMMOENG100) with water is addressed. This approach allows the preparation of thermoreversible ionogels with high ionic conductivity (up to 60 mS cm−1), remarkable mechanical properties (storage moduli above 105 Pa—a value comparable to the mechanical properties of some rubbers), and melting points in the range from −20 to 53 °C. These properties can be easily tuned in a broad range by varying the water (and/or inorganic salts) concentration in the ionogels. The described method is a very convenient way to prepare ionogels because it is based on simple and inexpensive materials, namely AMMOENG100 and water (no volatile organic solvents involved). Infrared measurements suggested that the observed gelation phenomenon might occur via the formation of a hydrogen bonded network between water and the AMMOENG100 ionic liquid.
ChemInform Abstract: Asymmetric Michael Addition Reactions of Chiral Ni(II)‐Complex of Glycine with (N‐trans‐Enoyl)oxazolidines: Improved Reactivity and Stereochemical Outcome. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Photochromism and Kinetics of Naphthacenequinones (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotochromism and Kinetics of NaphthacenequinonesJ. Malkin, A. Zelichenok, V. Krongauz, A. S. Dvornikov, and P. M. RentzepisCite this: J. Am. Chem. Soc. 1994, 116, 3, 1101–1105Publication Date (Print):February 1, 1994Publication History Published online1 May 2002Published inissue 1 February 1994https://doi.org/10.1021/ja00082a037RIGHTS & PERMISSIONSArticle Views187Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (539 KB) Get e-Alerts Get e-Alerts
Ingenol mebutate: potential for further development of cancer immunotherapy. (2012)

Ingenol mebutate is a diterpene ester derived from the plant Euphorbia peplus and is FDA approved for the topical treatment of actinic keratoses (AK). Shown to be efficacious with as little as a 3-day trial, this compound is being further tested for the topical treatment of other nonmelanoma skin cancers with promising preclinical data. In an effort to elucidate the molecular mechanism of this novel drug, Stahlhut et al. (2012) suggest a role for calcium and apoptosis. Further studies are needed to evaluate the intracellular mechanisms of ingenol mebutate-mediated cytotoxicity. Additionally, studies such as this not only shed light on the mechanism of ingenol mebutate and its derivatives, but also pave the way for evaluating the involvement of the immune system in eliminating drug-treated cells and tissues. This has important implications for the development of novel topical immune modulatory products and the field of topical immunotherapy.
Neighbour and network discovery in cognitive radio networks: research activities and results in the ACROPOLIS Network of Excellence (2013)

Cognitive radio networks operation relies on the capability to gather information about the surrounding environment, as regards both internal network status (presence and capabilities of other devices belonging to the same network) and external systems potentially coexisting with the cognitive network. In particular, retrieving information at the local level is a function required to all wireless networks, and goes under the name of neighbour discovery. Under this aspect, cognitive networks make no exception. Similarly, cognitive networks share with traditional wireless networks the necessity of a function for retrieving and exchanging information on a network wide scale, referred to in the following as network discovery. The definition of efficient neighbour and network discovery strategies for cognitive networks, taking into account their specific characteristics, is one of the goals of the research activities undergoing within the framework of the ACROPOLIS NoE. In this work, neighbour and network discovery solutions currently under investigation within the ACROPOLIS joint research activities are presented, and future research lines are identified. The paper first presents algorithms and results on neighbour discovery and Medium Access Control, and moves then to network wide protocols by presenting the work carried out in ACROPOLIS on routing for underlay cognitive networks. The paper provides then an overview on the common simulation platform developed within ACROPOLIS to investigate neighbour and network discovery, and finally discusses future research directions on such topics. © VDE VERLAG GMBH.
Neonatal pain assessment: Do we have the right tools? (2023)

A more comprehensive neonatal pain assessment tool and more provider education on differences in pain signals in premature neonates may be needed to increase the clinical utility of pain scales that address the different aspects of neonatal pain.
&lt;p&gt;Change Of Nano Material Electrical Characteristics For Medical System Applications&lt;/p&gt; (2019)

Amorphous nano oxides (AO) are intriguing advanced materials for a wide variety of nanosystem medical applications including serving as biosensors devices with p-n junctions, nanomaterial-enabled wearable sensors, artificial synaptic devices for AI neurocomputers and medical mimicking research. However, p-type AO with reliable electrical properties are very difficult to obtain according to the literature. Based on the oxide thin film transistor, a phenomenon that could change an n-type material into a p-type semiconductor is proposed and explained here. The typical In-Ga-Zn-O material has been reported to be an n-type semiconductor, which can be changed by physical conditions, such as in processing or bias. In this way, here, we have identified a manner to change nano material electrical properties among n-type and p-type semiconductors very easily for medical application like biosensors in artificial skin.
ChemInform Abstract: Cleavage of DNA by Nickel Complexes. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Recombinant human granulocyte-macrophage colony-stimulating factor in combination with standard induction chemotherapy in de novo acute myeloid leukemia (1991)

Based on in vitro data suggesting that recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is capable of stimulating acute myeloid leukemia (AML) blast cells to become more sensitive to cell-cycle-specific drugs we conducted a phase I/II study in de novo AML patients (pts). rhGM-CSF (250 micrograms/m2/d, continuous intravenous infusion) was administered in 18 pts suffering from de novo AML in combination with standard induction chemotherapy (3 + 7 = daunorubicin 45 mg/m2 days 1 through 3, cytosine-arabinoside [Ara-C] 200 mg/m2 continuous infusion days 1 through 7). GM-CSF was started 48 or 24 hours before chemotherapy (prephase) in 14 pts. In four pts with high white blood cell counts (WBC) rhGM-CSF was started after chemotherapy-induced cell reduction (WBC less than 30,000/mm3). During prephase GM-CSF induced an increase in neutrophil and blast cell counts in 13 of 14 and 10 of 14 pts, respectively. In vivo recruitment of leukemic cells into drug-sensitive phases of the cell cycle could be demonstrated by multiparameter cell-cycle analyses in peripheral blood (n = 7) and bone marrow (n = 4) specimens. On day 14, complete aplasia was evident in 17 of 18 pts. GM-CSF was administered until recovery from chemotherapy-induced myelosuppression (absolute neutrophil counts, [ANC] greater than 500/mm3). Fifteen pts (83%) achieved complete remission, 12 did so with one cycle. A shorter duration of neutropenia was evident in these pts compared with historical controls (n = 39), (ANC greater than 500/mm3, day 22.5 +/- 3.4 v 25.2 +/- 3.7, P less than .05). Three pts achieved complete remission after a second cycle (same combination of rhGM-CSF and 3 + 7). Two pts died during bone marrow aplasia because of invasive pulmonary aspergillosis. Clinical side effects possibly related to GM-CSF, mainly fever, diarrhea, and weight gain were mild and tolerable (World Health Organization toxicity grade less than or equal to 2). Together, rhGM-CSF recruits kinetically quiescient AML cells in vivo to enter drug-sensitive phases of the cell cycle and promotes early myeloid recovery from aplasia after exposure to standard induction chemotherapy for AML.
GENE-19. DEEP PROTEOMIC SURVEY ACROSS SEVEN CHILDHOOD BRAIN TUMORS (2019)

Genomic characterization has allowed for the differentiation of different tumor types based upon the abundance of gene transcripts. However, owing to the many layers of regulation between transcript and the post-translationally modified protein, the functional moiety of the cell, it has been challenging to extrapolate biology from these transcriptional differences. We hypothesized that a comparative analysis of the proteome and phosphoproteome across 7 childhood brain tumors would yield a deeper understanding of the differences in their functional biology. We performed tandem mass tag labeling and triple mass spectrometry of 226 fresh frozen tumor samples collected in a single institution representing the histologic diagnoses of: high grade astrocytoma (27), low grade astrocytoma (97), ganglioglioma (20), ependymoma (32), medulloblastoma (22), atypical teratoid rhabdoid tumor (12), and craniopharyngioma (16). Among these samples were 22 pairs from pre/post recurrence. Across this sample set, we quantified 9155 proteins and 13632 phospho sites. After data preprocessing including normalization, batch correction and missing value imputation, we performed consensus clustering and showed that protein profiles can effectively distinguish major histology types. Additional regression based differential analyses revealed groups of proteins and pathways showing distinct activity patterns across different histologic types. Further leveraging the WGS data, we characterized the functional impact of mutation and fusion features of the glial tumors. Specifically, focusing on the largest cohort, low grade glioma, we analyzed the proteomic ramifications of BRAF status: V600E, BRAF-fusion and wild type. Moreover, from the primary and recurrent tumor pairs, we discovered the upregulation of proteins associated with immune evasion in more advanced LGG tumors. The incorporation of the proteomic dimension into large scale efforts at tumor characterization adds functional insight that can help drive translational efforts.
Usage of Bi-HTS in High Field Magnets (2004)

At present, superconducting high field magnets built up of metallic low temperature superconductors (LTS) like NbTi and ternary/quaternary Nb/sub 3/Sn is near to the upper limit of achievable field strength. Fields above approx. 23 T seem to be only reachable with LTS-HTS hybrid configurations consisting of an outer LTS section and a high temperature superconductor (HTS) insert. Commercially available Bi-HTS wires were investigated for their application in high field facilities like the HOMER II system with the goal of 25 T and in new generations of NMR magnets of 1000 MHz and above. Therefore the superconducting properties of the HTS wires were examined at 4.2 K in magnetic fields up to 10 T. The voltage-current relation was examined resistively using a high resolution four-point measurement technique. The dependence of the critical current and the n-value on the winding diameter, on the field alteration (increasing/decreasing), and on the field orientation to the wire is presented and discussed.
Abstract 222: Use of a Decision Support Tool for Ischemic Stroke Treatment in a Telehealth System (2017)

Background: Alteplase does not uniformly benefit patients with acute ischemic stroke (AIS). Variable times since symptom onset, age, comorbidities and symptom severity add much uncertainty to physicians’ ability to knowledgeably individualize clinical decision-making. This contributes to the recent controversy regarding ACEP-authored expert guidelines which support presentation of risks and benefits and a process of shared decision-making. We previously developed the RESOLVE decision support tool for generating personalized estimates of the benefits and risk of alteplase and developed implementation strategies for both the Emergency Department (ED) and Telehealth settings. This study was a survey of physicians in rural hospitals within a large stroke network to quantify physician’s satisfaction and confidence in treating AIS after having access to the RESOLVE tool. Methods: To provide rural ED physicians access to the RESOLVE decision support tool prior to the administration of alteplase for AIS, nurses at a centralized Telehealth system were trained to enter the data elements required to run the RESOLVE model and fax the tool to the rural hospital immediately, while the provider was waiting for a neurologist’s consultation from the comprehensive stroke center. We then conducted semi-structured interviews of rural hospital physicians who used the tool as soon as possible. We interviewed 14/28 physicians at 7 critical access hospitals, 6 rural community hospital and one urban public that used the RESOLVE tool in decision making during a 6 month pilot. Results: Providers strongly agreed the tool was helpful in discussing potential risks and benefits with the patient or family. Having the knowledge of the individualized patient risk of hemorrhage, and being able to inform the patient/family, was a theme that emerged from qualitative analyses of the interviews. “Knowing the risk of hemorrhage was only 3% made me more comfortable giving IV tPA” - ED Physician, Critical Access Hospital “[I] used it to discuss the risk of hemorrhage with the patient/family. That was very helpful.” - ED Physician, Urban Public Hospital “…used it to discuss the benefits and risks, having it helped me to know what to discuss with the patient/family.” - ED Physician, Rural Community Hospital Study limitations included the difficulty in interviewing physicians due to 12-hour work shift and those practicing as a locum tenens. Additionally, the timing and fax location was a limitation in some physicians seeing the tool prior to prior to treatment. Conclusions: The preliminary results showed the rural hospital providers saw value in the RESOLVE tool while discussing the risks and benefits with patient/family. Future strategies would include process changes to expedite the faxing of the RESOLVE tool.
Laparoscopic Nephrectomy and Nephroureterectomy for Renal and Upper Tract Transitional Cell Cancer (2000)

The best management for renal tumors is surgical excision. The laparoscopic technique of radical or total nephrectomy for renal cell carcinoma and radical nephroureterectomy for transitional cell carcinoma is rapidly gaining momentum as an effective method of extirpative surgery. The transperitoneal and retroperitoneal approach to either of these procedures is proving to be equally effective to open surgery with respect to tumor removal, providing similar disease-free rates. Laparoscopic surgery leads to a significantly lower intraoperative blood loss, postoperative analgesic requirement, and quicker convalescence. Presently the only drawbacks to laparoscopic surgery are longer operative times and higher costs. Fortunately, these factors are slowly approaching those of open surgery because of increased experience, improved instrumentation, and modification of the surgical technique.