gebhart/patrepeval huggingface dataset:
Solution processing of active semiconducting polymers and conducting polymer anodes for fabricating photodetectors (2003)

The light-detecting properties were studied for devices fabricated by a method involving screen-printing of an active semiconducting polymer layer. The active layer in the device is a blend consisting of an intrinsically n-type polymer poly(benzimidazobenzophenanthroline) dispersed in a matrix of intrinsically p-type polymer poly(3-octylthiophene). The anode in the device is a doped conducting polymer. The photocarrier generation efficiencies in the active layer are enhanced due to formation of donor–acceptor networks at small length scales. The solution processing is advantageous in forming devices on flexible and curved substrates.
Experiments and Cohesive Zone Model Parameters for T650/AFR-PE-4/FM680-1 at High Temperatures (2011)

This paper reports an experimental program to establish a cohesive zone model for the T650/AFR-PE-4 (laminate) and FM680-1 (adhesive) system. The cohesive zone model is based on a four parameter characterization: in each mode, a range of values for the critical energy release rate and cohesive strength are computed from a set of experimental results. Values of each parameter are determined over the temperature range of 20–350°C. Owing to experimental limitations, two methods for determining the Mode I critical energy release rate are reported from the double cantilever beam test: the area method and the inverse method. The Mode I strength is determined from a button peel stress test. The values of the Mode II parameters are determined by using a mapping procedure that accounts for multiparameter dependence in models of the end notch flexure and single lap joint tests.
Therapeutic Validation of GEF-H1 Using a De Novo Designed Inhibitor in Models of Retinal Disease (2022)

Inflammation and fibrosis are important components of diseases that contribute to the malfunction of epithelia and endothelia. The Rho guanine nucleotide exchange factor (GEF) GEF-H1/ARHGEF-2 is induced in disease and stimulates inflammatory and fibrotic processes, cell migration, and metastasis. Here, we have generated peptide inhibitors to block the function of GEF-H1. Inhibitors were designed using a structural in silico approach or by isolating an inhibitory sequence from the autoregulatory C-terminal domain. Candidate inhibitors were tested for their ability to block RhoA/GEF-H1 binding in vitro, and their potency and specificity in cell-based assays. Successful inhibitors were then evaluated in models of TGFβ-induced fibrosis, LPS-stimulated endothelial cell-cell junction disruption, and cell migration. Finally, the most potent inhibitor was successfully tested in an experimental retinal disease mouse model, in which it inhibited blood vessel leakage and ameliorated retinal inflammation when treatment was initiated after disease diagnosis. Thus, an antagonist that blocks GEF-H1 signaling effectively inhibits disease features in in vitro and in vivo disease models, demonstrating that GEF-H1 is an effective therapeutic target and establishing a new therapeutic approach.
Identification of sample mix-ups and mixtures in microbiome data in Diversity Outbred mice (2021)

In a Diversity Outbred mouse project with genotype data on 500 mice, including 297 with microbiome data, we identified three sets of sample mix-ups (two pairs and one trio) as well as at least 15 microbiome samples that appear to be mixtures of pairs of mice. The microbiome data consisted of shotgun sequencing reads from fecal DNA, used to characterize the gut microbial communities present in these mice. These sequence reads included sufficient reads derived from the host mouse to identify the individual. A number of microbiome samples appeared to contain a mixture of DNA from two mice. We describe a method for identifying sample mix-ups in such microbiome data, as well as a method for evaluating sample mixtures in this context.
An Investigation of a Falling Film Desiccant Dehumidification/ Regeneration Cooling System (2006)

The present work outlines a liquid desiccant refrigeration cycle with a significantly higher efficiency, as compared to a traditional chiller cycle operating between the same two thermal reservoirs. The present investigation includes a general cooling design under nominal values. A parametric study enables the determination of the overall cooling and humidity levels as compared to the ambient conditions. Typical cooling achieved by this analysis is approximately 17°C below the ambient temperature, and the relative humidity of the inlet air can be reduced up to 22 percent. The proposed cycle yields a 18–23 percent higher coefficient of performance as compared to a chiller cycle operating between the same temperatures. The proposed dehumidifier displays close agreement when compared to a standard cross-flow heat exchanger and the general trends and performance of this cycle compare well with previous studies on falling film dehumidifiers.
Optimal Resource Allocation for Parallel Reservoir Simulation (2019)

Over the past few decades, the oil and gas (O&G) industry has become heavily dependent on parallel scientific computing. The turnaround time of such applications depends heavily on the amount of resources dedicated to the task. Increasing the number of compute processes for the same job tends to produce diminishing returns, and does not always guarantee an increase in performance of a justified impact. This point describes scalability limits, which this work aims to avoid surpassing. An algorithm is presented in which a reservoir simulation run automatically adjusts and finds the optimal resources, which leads to improved performance, and the efficient utilization of compute resources, resulting in significant cost savings.
Efficacy and safety of gadobutrol‐enhanced MRA of the renal arteries: Results from GRAMS (Gadobutrol‐enhanced renal artery MRA study), a prospective, intraindividual multicenter phase 3 blinded study (2017)

1 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2018;47:572-581.
ESM-1 siRNA Knockdown Decreased Migration and Expression of CXCL3 in Prostate Cancer Cells (2017)

Endothelial cell-specific molecule-1 (ESM-1), also known as endocan, is a soluble proteoglycan expressed by the vascular endothelium, which also circulates in the bloodstream. Inflammatory cytokines and proangiogenic growth factors increase its expression, and increased serum levels have been reported in several cancer types and immunocompetent patients with sepsis. The aim of this study was to analyze the expression profile of CXC-chemokines and the effects of ESM-1 gene knockdown in proliferation, migration and CXC-chemokine expression in highly metastatic human prostate PC-3 cells. Expression profiles of CXC-chemokines were analyzed in metastatic PC-3 and non-tumorigenic PWR-1E cells. siRNA-mediated knockdown of ESM-1 was performed into PC-3 cells, which were subsequently tested for cell migration and proliferation. Effect of siRNA transfection on CXC-chemokine expression was further quantified at the transcript and protein level. RT-qPCR analysis and sandwich ELISA assay revealed higher levels of ESM-1 and several CXC-chemokines in metastatic PC-3 cells compared to non-tumorigenic PWR-1E. Transfection of PC-3 cells with ESM-1-siRNA decreased cell migration with no effect on proliferation, and it was accompanied by decrease in the transcript and protein levels of the angiogenic chemokine CXCL3. We report here for the first time the ESM-1 targeting in PC-3 cells, which resulted in decreased migration, which may be related, at least in part, to decreased expression of the angiogenic CXCL3 chemokine, whose expression was found to be reduced in ESM-1-siRNA transfected cells. Additional studies are required to ascertain the biological role of ESM-1 in prostate cancer cells and the link with the expression of CXCL3.
Purification and partial characterization of proline dehydrogenase from <i>Clostridium sporogenes</i> (1981)

A proline dehydrogenase which catalyzes the nicotinamide adenine dinucleotide (NAD) dependent oxidation of proline and the NADH-dependent reduction of delta 1-pyrroline 5-carboxylic acid (PCA) was purified from extracts of Clostridium sporogenes. Following purification, only one protein band was found on analytical polyacrylamide disc gels and on sodium dodecyl sulfate (SDS) - polyacrylamide disc gels. Sucrose density gradient centrifugation and SDS-gel electrophoresis indicated that the enzyme has a molecular weight of approximately 217 000 and consists of two subunits of equal size. During purification of proline dehydrogenase on hydroxylapatite the ratio of dehydrogenase activity to reductase activity decreases significantly, and a similar change in ratio was brought about by storage of partially purified enzyme preparations in low ionic strength buffers. Subsequent purification did not change the ratio. The dehydrogenase activity of proline dehydrogenase was inhibited by L-glutamate (Ki = 0.32 mM at pH 7.4 and Ki = 0.65 mM at ph 10.2). However, the reductase activity of the purified enzyme was not affected by 100 mM L-glutamate.
SCHOTT: Glass Technology for Waveguide-Based AR/MR Devices (2021)

More SCHOTT RealView® and more than RealView®. AR/MR content rarely fills a headset’s full field of view – the display subsystem processes sparse data. This then begs the question: why transmit full video frames and consume the power if you don’t need to? In this presentation, CP will introduce a new generation of microdisplay technology platform IntelliPixTM. The breakthrough design of IntelliPix only activates the pixels that need refreshing, which results in high image quality while drastically lowering display subsystem power. CP will also highlight the other technology features of the platform that enable pixels as small as 2.5µm while unlock the real potential in AR/MR for amplitude LCoS, emerging microLED and future phase-based holographic systems.
How Does Multiple-Packet Reception Capability Scale the Performance of Wireless Local Area Networks? (2010)

Thanks to its simplicity and cost efficiency, wireless local area network (WLAN) enjoys unique advantages in providing high-speed and low-cost wireless services in hot spots and indoor environments. Traditional WLAN medium-access-control (MAC) protocols assume that only one station can transmit at a time: simultaneous transmissions of more than one station cause the destruction of all packets involved. By exploiting recent advances in PHY-layer multiuser detection (MUD) techniques, it is possible for a receiver to receive multiple packets simultaneously. This paper argues that such multipacket reception (MPR) capability can greatly enhance the capacity of future WLANs. In addition, the paper provides the MAC-layer and PHY-layer designs needed to achieve the improved capacity. First, to demonstrate MPR as a powerful capacity-enhancement technique, we prove a "super-linearity" result, which states that the system throughput per unit cost increases as the MPR capability increases. Second, we show that the commonly deployed binary exponential backoff (BEB) algorithm in today's WLAN MAC may not be optimal in an MPR system, and that the optimal backoff factor increases with the MPR capability, the number of packets that can be received simultaneously. Third, based on the above insights, we design a joint MAC-PHY layer protocol for an IEEE 802.11-like WLAN that incorporates advanced PHY-layer signal processing techniques to implement MPR.
Combined Androgen Administration and HDAC Inhibition in Experimental Cancer Cachexia (2017)

Background:
Cancer cachexia impacts the majority of advanced cancer patients but no approved anti-cachexia therapeutic exits. Recent late stage clinical failures of anabolic anti-cachexia therapy revealed heterogeneous responses to anabolic therapies and a limited ability to translate improved body composition into functional benefit. It is currently unclear what governs anabolic responsiveness in cachectic patient populations. 
Methods:
We evaluated anabolic androgen therapy combined with the novel anti-cachectic histone deacetylase inhibitor (HDACi) AR-42 in a series of studies using the C-26 mouse model of experimental cachexia. The ability of treatment to suppress tumor-mediated catabolic signaling and promote anabolic effects were characterized.
Results:
Anabolic anti-cachexia monotherapy with the selective androgen receptor modulator (SARM) GTx-024 or enobosarm had no impact on cachectic outcomes in the C-26 model. A minimally effective dose of AR-42 provided mixed anti-cachectic benefits when administered alone but when combined with GTx-024 significantly improved bodyweight (p <0.0001), hind limb muscle mass (p <0.05), and voluntary grip strength (p <0.0001) versus tumor bearing controls. Similar efficacy resulted from the combination of AR-42 with multiple androgens. Anti-cachectic efficacy was associated with the ability to reverse pSTAT3 and atrogene induction in gastrocnemius muscle of tumor-bearing animals in the absence of treatment-mediated changes in serum IL-6 or LIF.
Conclusions:
Anabolic GTx-024 monotherapy is incapable of overcoming catabolic signaling in the C-26 model of experimental cachexia. Anti-cachectic androgen therapy is greatly improved by successful blockade of STAT3 mediated atrophy with AR-42. Combined androgen and HDAC inhibitor administration represents promising approach to improve anabolic response in cachectic patient populations.
Improvement of quality of oocytes collected in the autumn by enhanced removal of impaired follicles from previously heat-stressed cows (2001)

The fertility of dairy cows decreases during the summer and remains low during the cooler autumn although the animals are no longer under heat stress. The aim of this study was to characterize a delayed effect of summer heat stress on oocyte quality in the autumn and to improve oocyte quality by enhanced removal of follicles damaged during the previous summer. Lactating cows (n = 16) were subjected to heat stress during the summer. In autumn, ovarian follicles (3-7 mm in diameter) were aspirated by an ultrasound-guided procedure during four consecutive oestrous cycles. Follicles were aspirated from control cows on day 4 and from treated cows on days 4, 7, 11 and 15 of each oestrous cycle. All cows received PGF(2alpha) and GnRH injections on days 19 and 21, respectively, and maintained cyclicity, as indicated by plasma progesterone concentrations. On day 4 of each cycle, the oocytes recovered were examined morphologically, matured and activated in vitro, and cultured for 8 days. In cycle 1 (early October) both groups showed low percentages of grade 1 oocytes, cleavage, four- and eight-cell embryos, morulae and parthenogenetic blastocysts. Subsequently, the number of grade 1 oocytes increased earlier (cycle 2) in treated than in control cows (cycle 3; P < 0.05). The cleavage rate in the control group remained relatively low throughout (32-58%), whereas in the treated group it increased from 40% (cycle 1) to 75% (cycles 3 and 4; P < 0.05). The number at each stage of embryo development increased slightly but remained low throughout in the control group, whereas in the treated group significant (P < 0.05) increases of all stages were observed in cycles 3 and 4. The results show a delayed effect of summer heat stress on oocyte quality and embryo development in the autumn. Enhanced removal of the impaired cohort of follicles led to earlier emergence of healthy follicles and high quality oocytes in the autumn.
Intramolecular charge transfer and thermal exciplex dissociation with p-aminobenzonitriles in toluene (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular charge transfer and thermal exciplex dissociation with p-aminobenzonitriles in tolueneUwe Leinhos, Wolfgang Kuehnle, and Klaas A. ZachariasseCite this: J. Phys. Chem. 1991, 95, 5, 2013–2021Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/j100158a024https://doi.org/10.1021/j100158a024research-articleACS PublicationsRequest reuse permissionsArticle Views615Altmetric-Citations201LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
A novel framework for storage, analysis and integration through mediation of large-scale electrophysiological data (2011)

We present a framework based on object orientation with novel principles for how to store, analyze and integrate electrophysiological data. These principles are: (I) Using a Decorator pattern for storing analysis data in an object model, (II) using a Core Classes data structure for integration through mediation in a service bus architecture, and (III) choosing the single unit as the finest structure of the object model. With these principles, we address the problems of (1) how to relate the analysis data to the original electrophysiological data by utilizing design patterns, (2) how to integrate data from different data sources, both at application and organization levels and (3) avoiding performance problems by choosing the correct level of object granularity for the data.
Dataset associated with "Diameter-independent skyrmion Hall angle observed in chiral magnetic multilayers" (2019)

Magnetic skyrmions are topologically non-trivial nanoscale objects. Their topology, which originates in their chiral domain wall winding, governs their unique response to a motion-inducing force. When subjected to an electrical current, the chiral winding of the spin texture leads to a deflection of the skyrmion trajectory, characterized by an angle with respect to the applied force direction. This skyrmion Hall angle was believed to be skyrmion diameter-dependent. In contrast, our experimental study finds that the skyrmion Hall angle is diameter-independent for skyrmions with diameters ranging from 35 to 825nm. At an average velocity of 6 ± 1 m/s, the average skyrmion Hall angle was measured to be 9° ± 2°. In fact the skyrmion dynamics is dominated by the local energy landscape such as materials defects and the local magnetic configuration.
High and stable Q-factor in resonant MEMS with Getter film (2006)

The need to reach high and stable values of the Q-factor is one of the most important issues of resonant MEMS in order to make high-performance sensors. The Q-factor is strongly influenced by the internal environment of the MEMS packaging, by total pressure and by gas composition. The most experienced and technically accepted way to keep the atmosphere stable in a hermetically sealed device is to use a getter material that is able to chemically absorb active gases under vacuum or in inert gas atmosphere for the lifetime of the devices. MEMS hermetically bonded devices such as gyroscopes, accelerometers, pressure and flow sensors, IR sensors, RF-MEMS and optical mirrors requires getter thin film solutions to work properly. Getter technical solution for wafer to wafer hermetically bonded MEMS systems is PaGeWafer, a silicon, glass or ceramic wafer ("cap wafer") with patterned getter film, few microns thick. In this paper, first the theoretical evaluation of Q-factor of a MEMS resonant structure in presence of a getter film is investigated and compared to the results of a Residual Gas Analysis of the same MEMS resonant structure and with the conventional measurement of Q-factor. Using getter thin film technology, total pressures down to 10<sup>-4</sup> mbar with corresponding high and stable Q-factors have been achieved in MEMS resonant structures. We were therefore able to confirm that getter films can provide high Q-values, stability of sensor signal, performances stability during the lifetime, removal of dangerous gases like H<sub>2</sub> and H<sub>2</sub>O in hermetically sealed MEMS resonant structures.
Genome sequence of the Medicago-nodulating Ensifer meliloti commercial inoculant strain RRI128 (2014)

Ensifer meliloti strain RRI128 is an aerobic, motile, Gram-negative, non-spore-forming rod. RRI128 was isolated from a nodule recovered from the roots of barrel medic (Medicago truncatula) grown in the greenhouse and inoculated with soil collected from Victoria, Australia. The strain is used in commercial inoculants in Australia. RRI128 nodulates and forms an effective symbiosis with a diverse range of lucerne cultivars (Medicago sativa) and several species of annual medic (M. truncatula, Medicago littoralis and Medicago tornata), but forms an ineffective symbiosis with Medicago polymorpha. Here we describe the features of E. meliloti strain RRI128, together with genome sequence information and annotation. The 6,900,273 bp draft genome is arranged into 156 scaffolds of 157 contigs, contains 6,683 protein-coding genes and 87 RNA-only encoding genes, and is one of 100 rhizobial genomes sequenced as part of the DOE Joint Genome Institute 2010 Genomic Encyclopedia for Bacteria and Archaea-Root Nodule Bacteria (GEBA-RNB) project.
Oligoethylene glycol-substituted aza-BODIPY dyes as red emitting ER-probes (2015)

This study features aza-BODIPY (BF2-chelated azadipyrromethene) dyes with two aromatic substituents linked by oligoethylene glycol fragments to increase hydrophilicity of aza-BODIPY for applications in intracellular imaging. To prepare these, two chalcones were attached α,ω onto oligoethylene glycol fragments, then reacted with nitromethane anion. Conjugate addition products from this reaction were then subjected to typical conditions for synthesis of aza-BODIPY dyes (NH4OAc, (n)BuOH, 120 °C); formation of boracycles in this reaction was concomitant with creation of macrocycles containing the oligoethylene glycol fragments. Similar dyes with acyclic oligoelythene glycol substituents in the same position were used to compare the efficiencies of the intra- and inter-molecular aza-BODIPY forming reactions, and the characteristics of the products. All the fluors with oligoethylene glycol fragments, i.e. cyclic or acyclic, localized in the endoplasmic reticulum of a fibroblast cell line (WEHI-13VAR), the human pancreatic cancer cell line (PANC-1, rough ER predominates) and human liver cancer cell line (HepG2, smooth ER prevalent). These fluors are potentially useful for near IR (λmax emis at 730 nm) ER staining probes.