gebhart/patrepeval huggingface dataset:
A Simple Approach of Electrolyte Development for Magnesium Ion Battery (2016)

Abundance of the magnesium element in the earth's crust and the safety features of Mg metal have attracted extensive attention for the development of rechargeable Mg battery. However, major roadblock for magnesium ion battery development is the availability of an electrolyte that can deposit Mg reversibly. Before the successful invention of a prototype Mg ion battery, optimization of the Mg electrolyte performance is necessary. Work presented here includes a new, non-halogen contained Mg electrolyte that can plate and strip Mg reversibly. Specifically, electrochemical evaluation of this new non-aqueous Mg electrolyte will be discussed. Figure 1
A novel single phase SRM simply driven by commercial AC power supply (2015)

Single phase IMs have been widely used in home appliances such as fans, pumps and so on because they are directly driven by commercial AC power supply. However, the motor efficiency is very low because the rotor winding and auxiliary winding generate large copper loss. Therefore, in this research, a novel single phase switched reluctance motor (SRM) which is directly driven by commercial AC power supply is proposed as an alternative for single phase IMs. The proposed drive system is consisted of only a half bridge diode rectifier and the motor structure enable the SRM to achieve continuous torque and start up. The performances of the prototype single phase SRM are verified by experiments, the results show that the efficiency and output power of single phase SRM are higher than that of single phase IMs.
Relationship between perceived stress, hair cortisol and burnout components in health workers during the second year of Covid 19 pandemic (2023)

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
Feature category systems for 2nd order local image structure induced by natural image statistics and otherwise (2007)

We report progress on an approach (Geometric Texton Theory - GTT) that like Marr's 'primal sketch' aims to describe image structure in a way that emphasises its qualitative aspects. In both approaches, image description is by labelling points using a vocabulary of feature types, though compared to Marr we aim for a much larger feature vocabulary. We base GTT on the Gaussian derivative (DtG) model of V1 measurement. Marr's primal sketch was based on DtG filters of derivative order up to 2<sup>nd</sup>, for GTT we plan to extend to the physiologically plausible limit of 4<sup>th</sup>. This is how we will achieve a larger feature vocabulary (we estimate 30-150) than Marr's 'edge', 'line' and 'blob'. The central requirement of GTT then is for a procedure for determining the feature vocabulary that will scale up to 4<sup>th</sup> order. We have previously published feature category systems for 1-D 1<sup>st</sup> order, 1-D 2<sup>nd</sup> order, 2-D 1<sup>st</sup> order and 2-D pure 2<sup>nd</sup> order. In this paper we will present results of GTT as applied to 2-D mixed 1<sup>st</sup> + 2<sup>nd</sup> order features. We will review various approaches to defining the feature vocabulary, including ones based on (i) purely geometrical considerations, and (ii) natural image statistics.
Optimize the Front-side Boron Emitter by Removing the Boron-depleted Region with Less Damage to the Texture Pyramids (2016)

In this work, we present n-type bifacial solar cells with a BBr3 thermally diffused emitter on the front side. Our study related mainly to the boron profiles of the front-side emitter. We optimized the front-side boron emitter by removing the boron-depleted region by means of a spin-etching technique. The boron profiles of non-etched and etched samples were examined. Passivation qualities were also studied on non-etched and etched symmetrical p+/n/p+ samples. A reduction in the emitter saturation current density J0e in the sample in which the depletion region had been etched was investigated. A high cell efficiency of 19.6% was achieved by removing the depleted region on the front side.
Towards a designed synthesis of metallic nanoparticles in polyols – elucidation of the redox scheme in a cobalt–ethylene glycol system (2016)

A new redox reaction mechanism in the formation of Co metal particles using an ethylene glycol–cobalt system is proposed using NMR, ESI-MS, FT-IR and XRD as analytical tools.
Avoiding Conjunctival Necrosis After Periocular Depot Corticosteroid Injection (2000)

Periocular injections of depot corticosteroids are often used to treat chronic inflammatory diseases of the eye.1 Increased intraocular pressure2 and cataract formation3 are well-recognized complications of periocular corticosteroid therapy. Inadvertent steroid injection into the choroidal or retinal circulation4 and perforation of the globe5 have also been reported. More recently, conjunctival necrosis has been described following the subconjunctival injection of 0.75 mL of methylprednisolone acetate suspension (80 mg/mL) in 1 patient3 and 40 mg triamcinolone acetonide in another.6 The clinical picture in these patients includes marked conjunctival inflammation and necrosis and extrusion of white material from the involved area.3,6 We recently examined 3 patients (3 eyes) with conjunctival necrosis after subconjunctival injection(s) of methylprednisolone (once, twice, and 7 times in the 3 patients). The patients had received the injections for treatment of chronic uveitis and presented to us 2 to 4 weeks after the last injection. The clinical picture (Figure 1) was similar to that described in the earlier reports.3,6 Routine bacterial and fungal cultures of the extruding white material and swabs of the conjunctival ulcer margins were negative. Since the underlying sclera appeared healthy, we opted to treat the patients conservatively. Topical and systemic antibiotics were used to prevent secondary infection in the ulcerated area. The lesions healed with conjunctival and subconjunctival scarring within 2 to 4 weeks (Figure 2).Figure 1.: (Fogla) Large areas of conjunctival necrosis in the superior temporal bulbar conjunctiva.Figure 2.: (Fogla) Healed conjunctival defects 1 month after initial examination.We have used posterior sub-Tenon injection7 of 0.5 mL triamcinolone acetonide (40 mg/mL) in our uveitis clinic for the past 15 years. We have not encountered conjunctival necrosis in any patient. Triamcinolone acetonide (4 mg) has been used as an intravitreal injection and is well tolerated by the eye.8 In contrast, the use of methylprednisolone has been reported to cause scarring and inflammation at the injection site, possibly from the use of polyethylene glycol as a vehicle.9 Our experience indicates that the use of 20 mg triamcinolone acetonide as a posterior sub-Tenon injection is safe and effective in the management of chronic uveitis. The dosage used and, more importantly, deposition of the depot steroid in the sub-Tenon's space probably prevents conjunctival toxicity. Injecting the steroid into the retrobulbar space has been reported to produce atrophy of orbital fat and is best avoided.10 We thus suggest that avoiding subconjunctival placement of depot corticosteroids, particularly methylprednisolone, may reduce the incidence of conjunctival necrosis after such injections. Rajesh Fogla DNB, FRCS Srinivas K. Rao DO Jyotirmay Biswas MS aTamil Nadu, India
IMMUNOPATHOLOGY OF PIG LIVERS USED IN CLINICAL EX-VIVO XENOPERFUSIONS: ACUTE VASCULAR REJECTION. (1999)

214 Introduction: The pathogenesis of pig livers used in clinical xenoperfusions has been described as different than classical hyperacute rejection. Discordant xenotransplantation in the face of antibody or complement depletion results in acute vascular rejection (AVR). AVR is characterized by xenoantibody binding to graft endothelium with fibrin deposition, and upregulation of inflammatory mediators and vasoactive enzymes including endothelin-1 (ET-1), and inducible nitric oxide synthase (iNOS). Patients with liver failure have diminished levels of complement and are less able to initiate hyperacute rejection than healthy subjects. The purpose of this study was to describe the immunopathology of AVR in pig-to-human-liver xenotransplantation. Methods: Pig livers (n=3) that were used in 3 separate clinical xenoperfusions were studied. CH50 levels as an indicator of serum complement activity were measured prior to perfusion for each patient (n=3). Biopsies of perfused livers were stained using hematoxylin and eosin, and immunostained for the presence of human IgM, IgG, and fibrin. Sections were also immunostained for vasoactive mediators: ET-1, endothelin converting enzyme (ECE-1), and iNOS. Results: Pig livers (n=3) were perfused for t=4.5, 6 and 11 hours for three different patients with liver failure. Complement activity was severely diminished preperfusion in each of the patients (CH50 26 ± 19 U, normal range 120-300 U). Histology revealed sinusoidal dilatation with parenchymal hemorrhage and neutrophil infiltration. The longest perfused liver (11 hours) had extensive macrovesicular steatosis. Immunostaining revealed diffuse sinusoidal binding of IgM and IgG to the portal and sinusoidal endothelium in all three livers. There was fibrin deposition in small and medium sized portal venules. ET-1 and ECE-1 stained prominently in the sinusoids in each of the livers. Staining for iNOS was also prominent in the sinusoidal endothelium as well. Conclusions: Injury of pig livers used in xenoperfusion in the absence of complement is consistent with AVR as described in pig-to-primate models of kidney and heart xenotransplantation.
Role of High-Resolution Magnetic Resonance Imaging in the Diagnosis of Primary Angiitis of the Central Nervous System (2014)

The present case emphasizes the importance of wall imaging in the diagnosis and treatment of PACNS.
Are simple verbal instructions sufficient to ensure that bladder volume does not deteriorate prostate position reproducibility during spot scanning proton therapy? (2021)

Our data demonstrated that there was no apparent relationship between BV changes and prostate position reproducibility and simple verbal instruction about urination could be sufficient for image-guided SSPT.
Development and Characterization of a Loop Heat Pipe With a Planar Evaporator and Condenser (2011)

We present the development and characterization of an air-cooled loop heat pipe with a planar evaporator and condenser. The condenser is mounted vertically above the evaporator, and impellers are integrated both sides of the condenser with tight clearance. The planar geometry allows for effective convective cooling by increasing the surface area and the convective heat transfer coefficient. To ensure condensation across the area of the condenser, a wicking structure is integrated in the condenser. The evaporator incorporates a multi-layer wicking structure to maintain a thermal gradient between the vapor and liquid regions, which is used to sustain the vapor and liquid pressures necessary for operation. The loop heat pipe was demonstrated to remove 140 W of heat at a temperature difference between the evaporator base and inlet air of 50 °C. This work is the first step towards the development of an air-cooled, multiple-condenser loop heat pipe.
Low Expression of DYRK2 (Dual Specificity Tyrosine Phosphorylation Regulated Kinase 2) Correlates with Poor Prognosis in Colorectal Cancer (2016)

Dual-specificity tyrosine-phosphorylation-regulated kinase 2 (DYRK2) is a member of dual-specificity kinase family, which could phosphorylate both Ser/Thr and Tyr substrates. The role of DYRK2 in human cancer remains controversial. For example, overexpression of DYRK2 predicts a better survival in human non-small cell lung cancer. In contrast, amplification of DYRK2 gene occurs in esophageal/lung adenocarcinoma, implying the role of DYRK2 as a potential oncogene. However, its clinical role in colorectal cancer (CRC) has not been explored. In this study, we analyzed the expression of DYRK2 from Oncomine database and found that DYRK2 level is lower in primary or metastatic CRC compared to adjacent normal colon tissue or non-metastatic CRC, respectively, in 6 colorectal carcinoma data sets. The correlation between DYRK2 expression and clinical outcome in 181 CRC patients was also investigated by real-time PCR and IHC. DYRK2 expression was significantly down-regulated in colorectal cancer tissues compared with adjacent non-tumorous tissues. Functional studies confirmed that DYRK2 inhibited cell invasion and migration in both HCT116 and SW480 cells and functioned as a tumor suppressor in CRC cells. Furthermore, the lower DYRK2 levels were correlated with tumor sites (P = 0.023), advanced clinical stages (P = 0.006) and shorter survival in the advanced clinical stages. Univariate and multivariate analyses indicated that DYRK2 expression was an independent prognostic factor (P < 0.001). Taking all, we concluded that DYRK2 a novel prognostic biomarker of human colorectal cancer.
Hypoxia-inducible factor-1α promotes cell survival during ammonia stress response in ovarian cancer stem-like cells (2017)

Ammonia is a toxic by-product of metabolism that causes cellular stresses. Although a number of proteins are involved in adaptive stress response, specific factors that counteract ammonia-induced cellular stress and regulate cell metabolism to survive against its toxicity have yet to be identified. We demonstrated that the hypoxia-inducible factor-1α (HIF-1α) is stabilized and activated by ammonia stress. HIF-1α activated by ammonium chloride compromises ammonia-induced apoptosis. Furthermore, we identified glutamine synthetase (GS) as a key driver of cancer cell proliferation under ammonia stress and glutamine-dependent metabolism in ovarian cancer stem-like cells expressing CD90. Interestingly, activated HIF-1α counteracts glutamine synthetase function in glutamine metabolism by facilitating glycolysis and elevating glucose dependency. Our studies reveal the hitherto unknown functions of HIF-1α in a biphasic ammonia stress management in the cancer stem-like cells where GS facilitates cell proliferation and HIF-1α contributes to the metabolic remodeling in energy fuel usage resulting in attenuated proliferation but conversely promoting cell survival.
[Iatrogenic thrombosis of the jugular vein. A case report]. (1987)

We report on a 52-year-old female patient who developed a thrombophlebitis with consecutive thrombosis of the internal jugular vein 14 days after hemicolectomy and prolonged central venous catheterisation. The tip of the polyethylene catheter was placed in the internal jugular vein. The pathophysiology of the thrombotic inflammation can be related to local alterations of the vessel wall due to mechanical irritation as well as hyperosmotic solutions on one side and bacterial infection on the other. The life threatening complications such as septicaemia, diffuse embolisation of other organs and the development of superior vena cava syndrome can be prevented only by instantaneous surgical removal of the jugular vein. Additionally, antibiotic and highdose heparine therapy are necessary. A review of the literature supports our experience.
Mad-1 Is the Exclusive JC Virus Strain Present in the Human Colon, and Its Transcriptional Control Region Has a Deleted 98-Base-Pair Sequence in Colon Cancer Tissues (2001)

JC virus (JCV), along with other members of the polyomavirus family, encodes a class of highly conserved proteins, T antigens, that are capable of inducing aneuploidy in cultured cells. We have previously isolated T-antigen DNA variants of JCV from both colon cancer tissues and the corresponding nonneoplastic gastrointestinal tissues, raising new questions about the role of JCV in the development of chromosomal instability of the colon. Based on the sequence of the transcriptional control region (TCR), JCV can be classified as archetype or tandem repeat variants. Among the latter, Mad-1, the prototype virus first isolated from a patient with progressive multifocal leukoencephalopathy, is characterized by lacking the 23- and 66-bp sequences that are present in the archetype and by duplication of a 98-bp sequence. In this study, we evaluated differences in the TCR of JCV isolated from colon cancer tissues and nonneoplastic epithelium. To characterize JCV variants, we first treated eight pairs of DNA samples from colon cancers and noncancerous tissue with topoisomerase I and then amplified and cloned the JCV TCR. We obtained 285 recombinant clones from the JCV TCR, 157 from nonneoplastic samples, and 128 from colon cancer tissues. Of these clones, 262 spanned the length of the JCV Mad-1 TCR: 99.3% from nonneoplastic samples and 82.8% from colon cancer tissues. In sequencing 54 clones in both directions, we did not find archetype JCV either in the nonneoplastic tissue or in the cancer samples. From all colon cancer tissues, 18 clones had a deletion of one 98-bp tandem repeat. This deleted strain was not detected in any of the nonneoplastic tissues (14 versus 0% [chi(2) = 23.6; P < 0.001]). Our study demonstrates that the only JCV strain present in the human colon is Mad-1, and the variant with a single 98-bp sequence is found exclusively in the cancer tissues. This strain may be involved in the development of chromosomal instability.
Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion (2017)

Cancer cell invasion from primary tumors is mediated by a complex interplay between cellular adhesions, actomyosin-driven contractility, and the physical characteristics of the extracellular matrix (ECM). Here, we incorporate a mechanochemical free-energy-based approach to elucidate how the two-way feedback loop between cell contractility (induced by the activity of chemomechanical interactions such as Ca<sup>2+</sup> and Rho signaling pathways) and matrix fiber realignment and strain stiffening enables the cells to polarize and develop contractile forces to break free from the tumor spheroids and invade into the ECM. Interestingly, through this computational model, we are able to identify a critical stiffness that is required by the matrix to break intercellular adhesions and initiate cell invasion. Also, by considering the kinetics of the cell movement, our model predicts a biphasic invasiveness with respect to the stiffness of the matrix. These predictions are validated by analyzing the invasion of melanoma cells in collagen matrices of varying concentration. Our model also predicts a positive correlation between the elongated morphology of the invading cells and the alignment of fibers in the matrix, suggesting that cell polarization is directly proportional to the stiffness and alignment of the matrix. In contrast, cells in nonfibrous matrices are found to be rounded and not polarized, underscoring the key role played by the nonlinear mechanics of fibrous matrices. Importantly, our model shows that mechanical principles mediated by the contractility of the cells and the nonlinearity of the ECM behavior play a crucial role in determining the phenotype of the cell invasion.
ChemInform Abstract: POLYPEPTIDES. PART 16. SYNTHESIS AND BIOLOGICAL ACTIVITY OF α‐AZA ANALOGS OF LULIBERIN WITH HIGH ANTAGONIST ACTIVITY (1979)

Abstract Die Analogen (I) von Luliberin mit modifizierten Bausteinen in Stellung 2, 6 und 10 werden nach klassischen Methoden durch Kondensation entsprechender Fragmente (III) und (IV) ‐ ihrerseits nach üblichen Verfahren schrittweise aufgebaut ‐ synthetisiert; die Analogen (II) ‐ mit fehlendem Baustein 2 ‐ werden ähnlich gewonnen.
Cryogenic Low-Drop-Out Regulators Fully Integrated with Quantum Dot Array in 22-nm FD-SOI CMOS (2021)

This brief presents two monolithically integrated output-capacitor-less (“caples”) low-drop-out (LDO) linear regulators implemented in 22-nm fully depleted silicon-on-insulator (FD-SOI) to support on-die scalable CMOS charge-based quantum processing unit (QPU). The proposed LDOs are used to regulate 0.8 V and 1.5 V input voltages for the programmable capacitive digital-to-analog converter (CDAC) and single-electron detector, respectively. Measured results show that both LDOs can maintain their respective output voltages with a maximum deviation <2% from ~270 K down to ~ 3.7 K.
On the secondary path of headset active noise cancellation systems (2012)

Active noise cancellation (ANC) technologies have been successfully applied in headsets to reduce ambient noise in the ear canal. The performance of such a technology depends on the characteristics of the secondary path (SP). In this paper, two different systems are studied: one system utilizes a moving-coil speaker as the secondary source and forms a closed cavity over the ear, while the other one uses a balanced-armature receiver inside the ear canal as the secondary source. The differences in the SP responses of these two systems are investigated both experimentally and theoretically. The implications for designing an effective ANC solution will be discussed based on numerical simulations.
Non-sexually related acute genital ulcers in 13 pubertal girls: a clinical and microbiological study. (2009)

We recommend serologic testing for Epstein-Barr virus with IgM antibodies to viral capsid antigens in non-sexually related AGU in immunocompetent patients. Further microbiological studies are required to identify other causative agents.
Faculty Opinions recommendation of Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by tandem UIMs of RAP80. (2009)

RAP80 has a key role in the recruitment of the Abraxas-BRCC36-BRCA1-BARD1 complex to DNA-damage foci for DNA repair through specific recognition of Lys 63-linked polyubiquitinated proteins by its tandem ubiquitin-interacting motifs (UIMs). Here, we report the crystal structure of the RAP80 tandem UIMs (RAP80-UIM1-UIM2) in complex with Lys 63-linked di-ubiquitin at 2.2 A resolution. The two UIMs, UIM1 and UIM2, and the a-helical inter-UIM region together form a continuous 60 A -long a-helix. UIM1 and UIM2 bind to the proximal and distal ubiquitin moieties, respectively. Both UIM1 and UIM2 of RAP80 recognize an Ile 44-centered hydrophobic patch on ubiquitin but neither UIM interacts with the Lys 63-linked isopeptide bond. Our structure suggests that the inter-UIM region forms a 12 A -long a-helix that ensures that the UIMs are arranged to enable specific binding of Lys 63-linked diubiquitin. This was confirmed by pull-down analyses using RAP80-UIM1-UIM2 mutants of various length inter-UIM regions. Further, we show that the Epsin1 tandem UIM, which has an inter-UIM region similar to that of RAP80-UIM1-UIM2, also selectively binds Lys 63-linked di-ubiquitin.
Supplementary Figure S3 from Relationship of Gene Expression and Chromosomal Abnormalities in Colorectal Cancer (2023)

Supplementary Figure S3 from Relationship of Gene Expression and Chromosomal Abnormalities in Colorectal Cancer