gebhart/patrepeval huggingface dataset:
Anwendungsgerechte Gestaltung von Schweißkonstruktionen (2007)

Stahlbauten bestehen aus einem System von Stäben (Skelett), deren Querschnitt klein im Verhältnis zur Länge ist. Im Gegensatz zum Massivbau mit seinen tragenden Wänden ist das Stahltragwerk nicht zugleich Raumabschluss.
Introducing Solubility Control for Improved Organic P-Type Dopants (2015)

To overcome the poor solubility of the widely used p-type dopant 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ), we have synthesized a series of structure-modified, organic p-type dopants to include alkyl ester groups designed to enable solubility and miscibility control. UV–vis–NIR and cyclic voltammetry measurements show increased solubility of mono- and diester substituted dopants with only modest changes to acceptor strength. Using absorption spectroscopy, photoluminescence, and in-plane conductivity measurements, we demonstrate that the new dopants can successfully p-type dope poly(3-hexylthiophene-2,5-diyl) (P3HT). Monoester substituted dopants are characterized by only slightly reduced electron affinity relative to F4TCNQ, but greater doping effectiveness due to increased miscibility with P3HT. Diester substituted dopants undergo a dimerization reaction before assuming their doped states, which may help anchor dopants into position post deposition, thus decreasing the negative effect of dopant drift and diffusion. We conclude that increased dopant solubility/miscibility increases the overall effectiveness of doping in solution-cast polymer films and that ester modification is a practical approach to achieving solubility/miscibility control in TCNQ-type dopants.
Sword tracer (2018)

This paper describes a system for visualizing sword trajectories in fencing. Fencing swords are very thin and move so fast that it is difficult for audiences to follow their movements even in slow-motion video replays. The system thus tracks the tips of the swords in the image coordinates and visualizes their movements with computer graphics (CG). We call it "Sword Tracer."
Synthetic Analogs of Intracellular Messengers (2003)

Signaling pathways that convert extracellular stimuli into intracellular responses regulate many diverse physiological and biochemical processes, and share many characteristics. An external signal binds to a cell surface receptor and stimulates a transducer to activate an internal effector, which initiates production of an intracellular messenger. The intracellular messenger sets in motion events that culminate in the overall cellular response, often by means of actions on protein kinases (Cohen, 1985).
A sift-based mode-seeking procedure for efficient, accurate registration of remotely sensed images (2013)

Several image registration methods, based on the scaled-invariant feature transform (SIFT) technique, have appeared recently in the remote sensing literature. All of these methods attempt to overcome problems encountered by SIFT in multi-modal remotely sensed imagery, in terms of the quality of its feature correspondences. The method presented in this paper performs mode seeking (in transformation space) to eliminate outlying corresponding key-points (i.e., features) and improve the overall match obtained. Preliminary experimental results seem to indicate that our method achieves high accuracy and is rather fast in a variety of test cases.
A new approach in ultrapurification of coal by selective flocculation. Final report (1992)

The specific objective of the present investigation is to develop a mathematical and computational model to elicit values of active sites ({phi}) and fractional surface coverage ({theta}) which would yield optimum separation of coal from coal pyrite and coal refuse. Attempts are to be made to select appropriate flocculants and experimental conditions to obtain {phi} and {theta} values as dictated by the theoretical model so as to achieve the desired separation in naturally occurring samples of fine coal. (VC)
Target tracking in heterogeneous sensor networks using audio and video sensor fusion (2008)

Heterogeneous sensor networks (HSNs) with multiple sensing modalities are gaining popularity in diverse fields. Tracking is an application that can benefit from multiple sensing modalities. If a moving target emits sound then both audio and video sensors can be utilized. These modalities can complement each other in the presence of high background noise that impairs the audio or visual clutter affecting the video. Audio-video tracking can also provide cues for the other modality for actuation. In this paper, we describe an approach for target tracking in urban environments utilizing an HSN of mote class devices equipped with acoustic sensor boards and embedded PCs equipped with web cameras. Our system employs a Markov Chain Monte Carlo Data Association algorithm for tracking vehicles emitting engine noise. Experimental results from a deployment in an urban environment are used to demonstrate our approach.
CCR7 is involved in the migration of neutrophils to lymph nodes (2010)

Increasing evidence suggests that neutrophils may participate in the regulation of adaptive immune responses, and can reach draining lymph nodes and cross-prime naive T cells. The aim of this study was to identify the mechanism(s) involved in the migration of neutrophils to the draining lymph nodes. We demonstrate that a subpopulation of human and mouse neutrophils express CCR7. CCR7 is rapidly expressed at the membrane upon stimulation. In vitro, stimulated human neutrophils migrate in response to the CCR7 ligands CCL19 and CCL21. In vivo, injection of complete Freund adjuvant induces a rapid recruitment of neutrophils to the lymph nodes in wild-type mice but not in Ccr7(-/-) mice. Moreover, intradermally injected interleukin-17-and granulocyte-macrophage colony-stimulating factor-stimulated neutrophils from wild-type mice, but not from Ccr7(-/-) mice, migrate to the draining lymph nodes. These results identify CCR7 as a chemokine receptor involved in the migration of neutrophils to the lymph nodes.
Flexural Phonons in Free-Standing Graphene (2008)

Rotation and reflection symmetries impose that out-of-plane (flexural) phonons of freestanding graphene membranes have a quadratic dispersion at long wavelength and can be excited by charge carriers in pairs only. As a result, we find that flexural phonons dominate the phonon contribution to the resistivity $\ensuremath{\rho}$ below a crossover temperature ${T}_{x}$ where we obtain an anomalous temperature dependence $\ensuremath{\rho}\ensuremath{\propto}{T}^{5/2}\mathrm{ln}﻿T$. The logarithmic factor arises from renormalizations of the flexural-phonon dispersion due to coupling between bending and stretching degrees of freedom of the membrane.
Characterization and expression of the murine CD3-epsilon gene. (1988)

The receptor for antigen on the surface of T lymphocytes consists of a variable disulfide-bridged hetero-dimer (TCR-alpha/beta or -gamma/delta) associated with invariant CD3 proteins (CD3-gamma, -delta, -epsilon, and -zeta). The genes coding for the CD3 proteins are expressed in the earliest recognizable thymocytes, preceding the rearrangement and expression of the TCR genes. The isolation, characterization, and in vitro expression of the murine CD3-epsilon gene, as reported here, represent obligatory steps toward our understanding of the complex rules that govern T-cell-specific gene expression. The CD3-epsilon gene was transcribed from a non-TATA promoter and consisted of eight exons, two of which were unusually small (18 and 15 base pairs). The transmembrane exon was found to be homologous to the transmembrane exons of the CD3-gamma and CD3-delta genes. In transient-transfection experiments, a genomic fragment comprising 4 kilobases of upstream sequence and extending into the second exon sufficient to drive the expression of a reporter gene in murine T cells.
Design of a scalable data stream channel for big data processing (2015)

This paper outlines big data infrastructure for processing data streams. Our project is distributed stream computing platform that provides cost-effective and large-scale big data services by developing data stream management system. This research contributes to advancing feasibility of big data processing for distributed, real-time computation even when they are overloaded.
Control of the Phase Fractions in Layered Rock Salt and Spinel-Type Li-(Mn,Co,Ni)-O Epitaxial Thin Films: a Model Blended Cathode System for Lithium Batteries (2015)

Control over the fractions of layered rock salt and spinel-type phases in Li-(Mn,Co,Ni)-O electrodes was demonstrated using a pulsed laser deposition method. Li-(Mn,Co,Ni)-O epitaxial thin films were deposited on a SrTiO3 (110) substrate and laser energy density (or fluence) was varied to obtain phase fraction control. X-ray diffraction measurements confirmed that the thin films had layered rock salt and spinel-type phases with (1-18) and (110) orientations, respectively. Systematic changes of the phase fraction with fluence variation were clearly confirmed. Relatively low fluence (<900 mJ cm−2) favors the formation of a layered phase while the spinel phase is obtained with higher fluence values (>1000 mJ cm−2). The lithium content in the film determines the fraction of each phase, and higher fluence values lead to lower lithium contents in the spinel phase. These two-phase films show lithium (de)intercalation activities with blended electrode characteristics in their cyclic voltammograms. These films could serve as model electrodes allowing analysis of the reactions of blended Li(Mn,Co,Ni)O2 systems under battery operation conditions.
A Sub-Micron Spherical Atomic Force Microscopic Tip for Surface Measurements (2020)

We report a novel methodology for fabricating a sub-micron spherical atomic force microscope (AFM) tip controllably-a silicon sub-micron sphere atop microcantilevers, which is desired for precise nanoscale tribology measurements, biological studies, and colloid science. Silicon sub-micron spheres are fabricated through swelling of single-crystal silicon with proper high-energy helium ion dosing, a traditionally undesired phenomenon known in helium ion microscopy. Silicon sub-micron spheres with diameters from 100 nm to 1 μm are demonstrated, and the placement of silicon sub-micron spheres can be as accurate as 10 nm or even below. This AFM tip demonstrates robust measurements during friction tests on graphene/silicon oxide substrates for more than 10 000 cycles. This AFM tip overcomes a critical challenge of reducing the size of spherical AFM tips from the micrometer scale to the sub-micron scale and is promising in cross-scale mechanics studies, nanotribology, colloid science, and biology.
A computational model of cerebellar saccadic control (1997)

This dissertation describes the development of a computational model, based on current knowledge of the anatomy and physiology of the cerebellum, to investigate possible strategies for saccadic processing. The model employs a novel and efficient method of neural simulation to create a detailed model, down to the molecular level, of a population of Purkinje cells and their interneuron inhibition. The model of the Purkinje cell population has approximately 300,000 compartments. Simulations are run on a moderately sized workstation (SGI R5000, 180MHz, 256Mb RAM). A typical simulation, which includes initialization and simulation of 8 different eye movements, takes approximately 12 hours. The model demonstrates that the firing patterns from a population of Purkinje cells can accurately encode the direction of a saccade and that a state machine (i.e. determination of subsequent motor commands based on previous motor commands and the current state of the motor system) is a robust strategy for the storage and execution of saccadic motor programs. The firing patterns of the model, during intact and lesion experiments, qualitatively match electrophysiological recordings in the cerebellum during saccades. The model suggests plausible explanations for the dysmetria seen in cerebellar lesion and Wallenberg's syndrome patients. The model simulates adaptation paradigms and shows that error correction is possible when climbing fiber input is periodic and contains no error signal. The present results demonstrate the ability of this modeling methodology to efficiently simulate complex behaviors without sacrificing important details.
Randomized, open‐label phase 2 study comparing frontline dovitinib versus sorafenib in patients with advanced hepatocellular carcinoma (2016)

Dovitinib was well tolerated, but activity was not greater than sorafenib as a frontline systemic therapy for HCC. Based on these data, no subsequent phase 3 study has been planned. (Hepatology 2016;64:774-784).
Mechanical properties of murine and porcine ocular tissues in compression (2014)

Sub-retinal implantation of foreign materials is becoming an increasingly common feature of novel therapies for retinal dysfunction. The ultimate compatibility of implants depends not only on their in vitro chemical compatibility, but also on how well the mechanical properties of the material match those of the native tissue. In order to optimize the mechanical properties of retinal implants, the mechanical properties of the mammalian retina itself must be carefully characterized. In this study, the compressive moduli of eye tissues, especially the retina, were probed using a dynamic mechanical analysis instrument in static mode. The retinal compressive modulus was lower than that of the sclera or cornea, but higher than that of the RPE and choroid. Compressive modulus remained relatively stable with age. Conversely, apparent retinal softening occurred at an early age in mice with inherited retinal degeneration. Compressive modulus is an important consideration for the design of retinal implants. Polymer scaffolds with moduli that are substantially different than that of the native tissue in which they will ultimately reside will be less likely to aid in the differentiation and development of the appropriate cell types in vitro and will have reduced biocompatibility in vivo.
Incorporating ScreenCasts into Chemical Engineering Courses (2020)

Abstract Incorporating ScreenCasts into Chemical Engineering Courses: If You Make Them, They Will WatchAn online inventory of ScreenCasts covering topics in chemical engineering has been created toprovide innovative resources for students and faculty in chemical engineering education.ScreenCasts are recordings with narration created on Tablet PCs, interactive whiteboards, etc.designed to supplement course lectures. Contrary to video lectures where a professor isvideotaped during class, ScreenCasts are shorter (~10 min) videos that demonstrate methods insolving example problems, provide instructional tutorials on using software in labs or courseassignments, and/or reinforce key topics in more detail than afforded in the classroom. With anincreasing amount of students possessing “information at their fingertips”, ScreenCasts provide atool for students anywhere to access at their own pace and time. Qualitative student feedbacksurveys during and after a course suggest that the majority of students find them “very useful” to“one of the best features of the course”.Our goal is to support faculty in developing ScreenCasts while providing a central location forsharing these resources. At www.learncheme.com, we have created an inventory of ScreenCastsin six core chemical engineering courses (thermodynamics, kinetics, materials & energybalances, fluids, separations, and heat transfer), as well as sections on engineering calculations,material science for all engineers and practice problems for the Fundamentals of Engineeringexam. Within 2 months of posting our initial ScreenCasts online, over a thousand visitors fromall over the world watched these ScreenCasts over 2,500 times. We have expanded further byposting our ScreenCasts on iTunes U which allows the viewer to download the videos. Currentlywe have produced almost 450 screencasts with 45,000 views and 43,000 downloads.We are in the progress of developing a methodology for creating successful ScreenCasts, asdetermined by student use and effectiveness in improving student understanding. We plan todiscuss various methods for creating ScreenCasts, reasons for and against spending time editingraw video, and how to disseminate them through a number of channels for students to accessonline. Qualitative surveys and online usage will also be documented and presented in supportof using ScreenCasts in chemical engineering courses. Finally, future plans for expanding andimproving our project will be presented.
Left Axillary Implantation of Loop Recorder (2010)

R-wave amplitude was determined at implantation and during follow-up. Each patient was followed after 7 days to optimize device setting and then at 1 and 3 months. The R-wave amplitude obtained with the new technique was significantly higher and more stable than that obtained with the standard procedure. Our preliminary experience suggests that axillary access for ILR implantation is feasible, safe, well tolerated, and reliable in terms of sensing function and device performance. Moreover, it is superior aesthetically to the standard approach and carries the potential of minimizing permanent scarring after ILR extraction.
Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease (2018)

Abstract Previous studies have demonstrated that temporarily increasing the permeability of the blood-brain barrier using focused ultrasound can reduce β-amyloid plaque load and improve cognitive function in animal models of Alzheimer’s disease. However, the underlying mechanism and duration for which the effects of one treatment persists for are unknown. Here, we used in vivo two-photon fluorescence microscopy to track changes in β-amyloid plaque sizes in the TgCRND8 mouse model of Alzheimer’s disease after one focused ultrasound treatment. We found that one treatment reduced plaques to 62 ± 16% ( p ≤ 0.001) of their original volume two days post-sonication; this decrease in size persisted for two weeks. We then sought to evaluate the effectiveness of biweekly focused ultrasound treatments using magnetic resonance imaging-guided focused ultrasound treatments. Three to five biweekly treatments resulted in a 27 ± 7% ( p ≤ 0.01) decrease in plaque number and 40 ± 10% ( p ≤ 0.01) decrease in plaque surface area compared to untreated littermates. This study demonstrates that one focused ultrasound treatment reduces the size of existing β-amyloid plaques for two weeks, and that repeated biweekly focused ultrasound treatments is an effective method of reducing β-amyloid pathology in moderate-to-late stages of Alzheimer’s disease.
A Framework for Emotions and Dispositions in Man-Companion Interaction (2013)

Human-human interaction implies numerous studies to significantly improve the efficiency, naturalness and persuasiveness in human-computer interaction (HCI) systems. But there is still inadequate knowledge on what and how cues interact in face-to-face interaction. The complexity of human-human interaction involving the description of verbal and non-verbal modalities still needs theoretical and empirical foundations. To achieve this goal, researchers need to develop resources and tools that enable them to take into account the different modalities. Verbal, vocal and gestural cues have been studied separately for a long time. This favored the precise description of the mechanisms and rules governing each domain. But today the question of how these various cues in the different modalities are connected, has become important for linguists.
Experimental flat-panel high-spatial-resolution volume CT of the temporal bone. (2004)

The flat-panel prototype provides better definition of fine osseous structures of temporal bone than that of currently available MSCT scanners. This study provides impetus for further research in increasing spatial resolution beyond that offered by the current state-of-the-art scanners.
A novel function of WAVE in lamellipodia: WAVE1 is required for stabilization of lamellipodial protrusions during cell spreading (2005)

When a cell spreads and moves, reorganization of the actin cytoskeleton pushes the cell membrane, and the resulting membrane protrusions create new points of contact with the substrate and generate the locomotive force. Membrane extension and adhesion to a substrate must be tightly coordinated for effective cell movement, but little is known about the mechanisms underlying these processes. WAVEs are critical regulators of Rac-induced actin reorganization. WAVE2 is essential for formation of lamellipodial structures at the cell periphery stimulated by growth factors, but it is thought that WAVE1 is dispensable for such processes in mouse embryonic fibroblasts (MEFs). Here we show a novel function of WAVE in lamellipodial protrusions during cell spreading. During spreading on fibronectin (FN), MEFs with knockouts (KOs) of WAVE1 and WAVE2 showed different membrane dynamics, suggesting that these molecules have distinct roles in lamellipodium formation. Formation of lamellipodial structures on FN was inhibited in WAVE2 KO MEFs. In contrast, WAVE1 is not essential for extension of lamellipodial protrusions but is required for stabilization of such structures. WAVE1-deficiency decreased the density of actin filaments and increased the speed of membrane extension, causing deformation of focal complex at the tip of spreading edges. Thus, at the tip of the lamellipodial protrusion, WAVE2 generates the membrane protrusive structures containing actin filaments, and modification by WAVE1 stabilizes these structures through cell-substrate adhesion. Coordination of WAVE1 and WAVE2 activities appears to be necessary for formation of proper actin structures in stable lamellipodia.
VideoTicket (2008)

Identity fraud (IDF) may be defined informally as exploitation of credential information using some form of impersonation or misrepresentation of identity, in the context of transactions. Thus, IDF may be viewed as a combination of two old problems: user authentication and transaction authorization. We propose an innovative approach to detect IDF attempts, by combining av-certificates (digitally-signed audiovisual recordings in which users identify themselves) with av-signatures (audiovisual recordings showing users' explicit consent for unique transaction details). Av- certificates may be used in on-site transactions, to confirm user identity. In the case of remote (e.g. web-based) transactions, both av-certificates and av-signatures may be used to authenticate users and verify their consent for transaction details. Conventional impersonation attacks, whereby credentials (e.g. passwords, biometrics, or signing keys) are used without the consent of their legitimate users, fail against VideoTicket. The proposed solution assumes that identity thieves have access to such credentials.
Comprehensive Molecular Characterization of Salivary Duct Carcinoma Reveals Actionable Targets and Similarity to Apocrine Breast Cancer (2016)

This study illuminates the landscape of genetic alterations and gene expression programs in SDC, identifying numerous molecular targets and potential determinants of response to AR antagonism. This has relevance for emerging clinical studies of ADT and other targeted therapies in SDC. The similarities between SDC and apocrine breast cancer indicate that clinical data in breast cancer may generate useful hypotheses for SDC. Clin Cancer Res; 22(18); 4623-33. ©2016 AACR.