gebhart/patrepeval huggingface dataset:
The impact of psychiatric comorbidity on the return to work in patients undergoing herniated disc surgery (2011)

Background/Objectives: Even though previous back surgery is assumed to be a potential risk factor for return to work (RTW) in back pain patients, only few studies investigated predictive factors for RTW in patients undergoing herniated disc surgery. Objectives of this study are: (1) to examine RTW and ability to work (ATW) rates in patients undergoing herniated disc surgery three months after surgical treatment; (2) to examine whether psychiatric comorbidity is associated with a higher risk for non-return to work (NRTW) and non-ability to work (NATW) respectively in patients undergoing disc surgery; and (3) to investigate which socio-demographic, illness-related, vocational and rehabilitation-related characteristics are associated with RTW and ATW.
Net-to-gross from Seismic P and S Impedances: Estimation and Uncertainty Analysis using Bayesian Statistics (2006)

Summary Net-to-gross (N/G ) is a measure of the amount of sand or pay in the overall reservoir and is used to appraise reservoir quality and the economics associated with reservoir development. As seismic based reservoir characterization technology is advancing in many cases lithology and porosity information derived from seismic inversion can be used to derive an estimate of N/G. In many cases this problem is non unique due to accuracy of seismic inversion and the rock physics nature of the lithology and porosity prediction. Thus as N/G estimates are often used for economic decision-making it is important to associate expected risk or confidence associated with the prediction. In this paper we we present a workflow to compute quantitative estimates of N/G, along with associated uncertainties, from well-log calibrated pre-stack seismic inversion attributes. The main tools we use in this workflow are Seismic (AVO) Inversion, Rock Physics, and Bayesian Statistics. We estimate the N/G from the seismically derived rock properties. We derive the uncertainty in net-to-gross from uncertainties in seismic inversion, reservoir properties, and geologic interpretation. Especially at the higher frequencies, the seismic data quality is poorer than the corresponding log data quality. In calibrating the seismic to the well-log data, we account for the log-to-seismic discrepancy in data quality.
Investigation of a New Family of Chiral Ligands for Enantioselective Catalysis via Parallel Synthesis and High-Throughput Screening (1998)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTInvestigation of a New Family of Chiral Ligands for Enantioselective Catalysis via Parallel Synthesis and High-Throughput ScreeningCesare Gennari, Simona Ceccarelli, Umberto Piarulli, Christian A. G. N. Montalbetti, and Richard F. W. JacksonView Author Information Università di Milano, Dipartimento di Chimica Organica e Industriale, Centro CNR per lo Studio delle Sostanze Organiche Naturali, via G. Venezian 21, I-20133 Milano, Italy, Università di Milano, Istituto di Scienze Mat. Fis. e Chimiche, via Lucini 3, 22100 Como, Italy, and University of Newcastle, Department of Chemistry, Bedson Building, Newcastle upon Tyne NE1 7RU, U.K. Cite this: J. Org. Chem. 1998, 63, 16, 5312–5313Publication Date (Web):July 23, 1998Publication History Received12 May 1998Published online23 July 1998Published inissue 1 August 1998https://pubs.acs.org/doi/10.1021/jo980890phttps://doi.org/10.1021/jo980890prapid-communicationACS PublicationsCopyright © 1998 American Chemical SocietyRequest reuse permissionsArticle Views800Altmetric-Citations97LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aldehydes,Anions,Ligands,Scaffolds,Screening assays Get e-Alerts
Supplementary Table 5 from Functional TLR5 Genetic Variants Affect Human Colorectal Cancer Survival (2023)

&lt;p&gt;PDF file - 32K, Multivariate analysis of CRC survival and the polymorphisms TLR5 rs5744174, TIRAP rs611953 and rs625413 and MyD88 rs4988453.&lt;/p&gt;
Characterization and Psychophysical Studies of an Air-Jet Lump Display (2012)

Development of tactile displays to enhance palpation of lumps during robot-assisted minimally invasive surgery is challenging due to size and weight constraints, motivating a pneumatic actuation strategy. This work describes the quantitative and psychophysical assessment of an air-jet tactile display that creates a lump percept by directing pressurized air through an aperture onto the finger. The air pressure and aperture size are meant to control the hardness and size, respectively, of the perceived lump. Jet impingement pressure and flow rate were measured by capacitive tactile sensors and mass flow meters at varying aperture sizes and pressures. The air-jet pressure profile width evolves as jet theory predicts and is largely independent of supply pressure (and therefore jet exit velocity). The method of constant stimuli was used to determine the just noticeable differences (JNDs) for the air pressure and aperture size. Qualitative results indicate that subjects perceive the stimulus as a "lump-like" shape. Pressure JNDs ranged from 19.6-24.4 kPag and aperture size JNDs ranged from 0.50-0.66 mm. No significant correlation exists between the supply pressure and changes in perceived lump size. However, pressure JNDs show significant (p < 0.001) inverse correlation with aperture size, with improved discrimination at larger apertures, where a greater finger pad area is stimulated.
Continuous-Time Bandpass Delta-Sigma Modulator for a Signal Frequency of 2.2 GHz (2009)

A continuous-time bandpass delta-sigma modulator (CT BPDSM) for class-S power amplifier applications with a center frequency of 2.2 GHz is presented. Class-S amplifiers are considered to provide a very power efficient way to amplify signals with high dynamic range. The modulator has a multi-feedback architecture. It features a low noise transconductor with series emitter degeneration, tunable LC resonators with Q-enhancement and an optimized clock tree operating at 7.5 GHz. The circuit is implemented in a 200 GHz-f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> SiGe-bipolar technology. A peak SNDR of 43 dB in a bandwidth of 20 MHz is measured. The circuit dissipates 450 mW from a 3.6 V supply.
Nano-Enabled COVID-19 Vaccines: Meeting the Challenges of Durable Antibody Plus Cellular Immunity and Immune Escape (2021)

At the time of preparing this Perspective, large-scale vaccination for COVID-19 is in progress, aiming to bring the pandemic under control through vaccine-induced herd immunity. Not only does this vaccination effort represent an unprecedented scientific and technological breakthrough, moving us from the rapid analysis of viral genomes to design, manufacture, clinical trial testing, and use authorization within the time frame of less than a year, but it also highlights rapid progress in the implementation of nanotechnology to assist vaccine development. These advances enable us to deliver nucleic acid and conformation-stabilized subunit vaccines to regional lymph nodes, with the ability to trigger effective humoral and cellular immunity that prevents viral infection or controls disease severity. In addition to a brief description of the design features of unique cationic lipid and virus-mimicking nanoparticles for accomplishing spike protein delivery and presentation by the cognate immune system, we also discuss the importance of adjuvancy and design features to promote cooperative B- and T-cell interactions in lymph node germinal centers, including the use of epitope-based vaccines. Although current vaccine efforts have demonstrated short-term efficacy and vaccine safety, key issues are now vaccine durability and adaptability against viral variants. We present a forward-looking perspective of how vaccine design can be adapted to improve durability of the immune response and vaccine adaptation to overcome immune escape by viral variants. Finally, we consider the impact of nano-enabled approaches in the development of COVID-19 vaccines for improved vaccine design against other infectious agents, including pathogens that may lead to future pandemics.
The alternating block decomposition of iterated integrals, and cyclic\n insertion on multiple zeta values (2017)

The cyclic insertion conjecture of Borwein, Bradley, Broadhurst and\nLison\\v{e}k states that by inserting all cyclic permutations of some initial\nblocks of 2's into the multiple zeta value $ \\zeta(1,3,\\ldots,1,3) $ and\nsumming, one obtains an explicit rational multiple of a power of $ \\pi $.\nHoffman gives a conjectural identity of a similar flavour concerning $ 2\n\\zeta(3,3,\\{2\\}^m) - \\zeta(3,\\{2\\}^m,(1,2)) $.\n In this paper we introduce the 'generalised cyclic insertion conjecture',\nwhich we describe using a new combinatorial structure on iterated integrals --\nthe so-called alternating block decomposition. We see that both the original\nBBBL cyclic insertion conjecture, and Hoffman's conjectural identity, are\nspecial cases of this 'generalised' cyclic insertion conjecture. By using\nBrown's motivic MZV framework, we establish that some symmetrised version of\nthe generalised cyclic insertion conjecture always holds, up to a rational;\nthis provides some evidence for the generalised conjecture.\n
Protein NMR for the Millennium. Biological Magnetic Resonance, Volume 20 Edited by N. Rama Krishna (University of Alabama at Birmingham) and Lawrence J. Berliner (University of Denver). Kluwer Academic/Plenum Publishers:  New York. 2003. xii + 342 pp. $135.00. ISBN 0-306-47448-4. (2003)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewProtein NMR for the Millennium. Biological Magnetic Resonance, Volume 20 Edited by N. Rama Krishna (University of Alabama at Birmingham) and Lawrence J. Berliner (University of Denver). Kluwer Academic/Plenum Publishers: New York. 2003. xii + 342 pp. $135.00. ISBN 0-306-47448-4.Richard W. Kriwacki and Charles GaleaView Author Information St. Jude Children's Research Hospital and University of Tennessee Health Science Center St. Jude Children's Research HospitalCite this: J. Am. Chem. Soc. 2003, 125, 51, 16155–16156Publication Date (Web):November 11, 2003Publication History Published online11 November 2003Published inissue 1 December 2003https://pubs.acs.org/doi/10.1021/ja033559ihttps://doi.org/10.1021/ja033559ibook-reviewACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views107Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Coupling reactions,Labeling,Nuclear magnetic resonance spectroscopy,Protein structure Get e-Alerts
α<sub>1</sub>-Antitrypsin deficiency and chronic respiratory disorders (2020)

α<sub>1</sub>-antitrypsin deficiency (AATD) is a hereditary disorder associated with a risk of developing liver disease and pulmonary emphysema, and other chronic respiratory disorders (mainly asthma and bronchiectasis); Z variant is the commonest deficient variant of AAT. Determining AAT concentration in serum or plasma and identifying allelic variants by phenotyping or genotyping are fundamental in the diagnosis of AATD. Initial evaluation and annual follow-up measurement of lung function, including post-bronchodilator forced expiratory volume in 1 s and gas transfer inform on disease progression. Lung densitometry is the most sensitive measure of emphysema progression, but must not be use in the follow-up of patients in routine clinical practice. The exogenous administration of purified human serum-derived AAT is the only approved specific treatment for AATD in PiZZ. AAT augmentation therapy is not recommended in PiSZ, PiMZ or current smokers of any protein phenotype, or in patients with hepatic disease. Lung volume reduction and endoscopic bronchial valve placement are useful in selected patients, whereas the survival benefit of lung transplant is unclear. There are several new lines of research in AATD to improve the diagnosis and evaluation of the response to therapy and to develop genetic and regenerative therapies and other treatments.
Anamorphic Imaging for Synthetic Holograms (1986)

Holographic stereograms synthesized from computer-graphic 2-D images rendered through idealized anamorphic optical systems permit penetration of the hologram plane without 3-D distortions.
Computer simulation of knee arthrometry to study the effects of partial ACL injury and tibiofemoral contact (2008)

We simulated the knee arthrometry test to obtain a deeper understanding of the joint's stability behavior and interpret the arthrometric results more effectively. A 2D sagittal plane finite element model of the lower limb in the standard configuration of knee arthrometry was developed using ANSYS APDL. A detailed model of the knee joint was considered including the femoral articulating contour represented by an ellipse, the tibial plateau represented by a circular arc, and four major knee ligaments and their individual bundles represented by linear and nonlinear tensile springs. A deformable layer of articular cartilage was also considered over the tibial plateau to simulate the bones engagement more precisely. The model was analyzed while the tibia was subjected to an anterior drawer force of up to 150 N with 10 N increments and the tibial anterior translation was obtained. Simulation of the arthrometry test for different curvatures of the tibial plateau revealed that the bones engagement has a considerable effect on the knee joint's laxity. However, a considerable change from the intact knee's data curve was only observed when the ACL total ruptured was simulated. This emphasizes the difficult task involved when trying to distinguish the partial injuries of the ACL using arthrometric data.
Immunostimulatory DNA Hydrogel Enhances Protective Efficacy of Nanotoxoids against Bacterial Infection (2023)

While vaccines have been highly successful in protecting against various infections, there are still many high-priority pathogens for which there are no clinically approved formulations. To overcome this challenge, researchers have explored the use of nanoparticulate strategies for more effective antigen delivery to the immune system. Along these lines, nanotoxoids are a promising biomimetic platform that leverages cell membrane coating technology to safely deliver otherwise toxic bacterial antigens in their native form for antivirulence vaccination. Here, in order to further boost their immunogenicity, nanotoxoids formulated against staphylococcal α-hemolysin are embedded into a DNA-based hydrogel with immunostimulatory CpG motifs. The resulting nanoparticle-hydrogel composite is injectable and improves the in vivo delivery of vaccine antigens while simultaneously stimulating nearby immune cells. This leads to elevated antibody production and stronger antigen-specific cellular immune responses. In murine models of pneumonia and skin infection caused by methicillin-resistant Staphylococcus aureus, mice vaccinated with the hybrid vaccine formulation are well-protected. This work highlights the benefits of combining nanoparticulate antigen delivery systems with immunostimulatory hydrogels into a single platform, and the approach can be readily generalized to a wide range of infectious diseases.
A Genome Scan in 260 Inflammatory Bowel Disease-Affected Relative Pairs (2003)

We report the results of a new genome scan in 260 IBD-affected relative pairs from 139 families that we have recruited since our previous IBD genome scans were performed. The goal of our study was to determine whether we could extend the linkage evidence in any of the more than 20 regions with nominal evidence for linkage to IBD in previous individual genome scans in order to prioritize regions for further study.
Plans should abstractly describe intended behavior (1996)

ly Describe Intended Behavior Karl Pfleger kpfleger@cs.stanford.edu Barbara Hayes-Roth bhr@hpp.stanford.edu Computer Science Department Stanford University Stanford, CA 94305 Abstract Planning is the process of formulating a potential course of action. How courses of action (plans) produced by a planning module are represented and how they are used by execution-oriented modules of a complex agent to influence or dictate behavior are critical architectural issues. In contrast to the traditional model of plans as executable programs that dictate precise behaviors, we claim that autonomous agents inhabiting dynamic, unpredictable environments can make better use of plans that only abstractly describe their intended behavior. Such plans only influence or constrain behavior, rather than dictating it. This idea has been discussed in a variety of contexts, but it is seldom incorporated into working complex agents. Experiments involving instantiations of our Adaptive Intelligent Systems ...
Experimental implantation of posterior chamber prototype intraocular lenses for the feline eye (1998)

IOL of substantially higher diopter strength than that needed in dogs was required to achieve emmetropia after lens extraction in cats. A 52- to 53-D IOL is required to correct feline eyes to near emmetropia after lens removal.
Robotic-Assisted Implantation of Ventricular Assist Device After Sternectomy and Pectoralis Muscle Flap (2014)

Left ventricular assist devices are increasingly important in the management of advanced heart failure. Most patients who benefit from these devices have had some prior cardiac surgery, making implantation of higher risk. This is especially true in patients who have had prior pectoralis flap reconstruction after sternectomy for mediastinitis. We outline the course of such a patient, in whom the use of robotic assistance allowed for a less invasive device implantation approach with preservation of the flap for transplantation.
Intraoperative Molecular Imaging in Lung Cancer: The State of the Art and the Future (2018)

Lung cancer is the deadliest malignant disease in the United States and has a median survival of only 5–11 months at advanced stages.1 However, for patients with stage I–IIIA cancers, minimally invasive surgery with curative intent plays a key role in treatment,2 and improving signal to noise in identifying diseased tissue is therefore critical in guiding resection. Non-targeted dyes, such as fluorescein (FITC) or indocyanine green (ICG), have long been administered pre-operatively to improve tumor contrast and have significantly improved surgical outcomes.
Transient model for the keyhole during laser welding (1999)

A novel approach to simulating the dominant dynamic processes present during concentrated energy beam welding of metals is presented. A model for the transient behaviour of the front keyhole wall is developed. It is assumed that keyhole propagation is dominated by evaporation-recoil-driven melt expulsion from the beam interaction zone. Results from the model show keyhole instabilities consistent with experimental observations of metal welding, metal cutting and ice welding.
2020–2021 Vegetable Production Guide: Chapter 8. Eggplant Production (2020)

1 0.25-0.5 0.25-0.5 Seed per acre to transplant (lb) 0.25-0.
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD (2014)

Previous work has shown that Tourette's syndrome and OCD have some degree of shared genetic variation. However, the data from this study suggest that there are also distinct components to the genetic architectures of these two disorders. Furthermore, OCD with co-occurring Tourette's syndrome/chronic tics may have different underlying genetic susceptibility compared with OCD alone.
Supplementary Methods from Novel Mechanism of Tumor Suppression by Polarity Gene &lt;i&gt;Discs Large 1&lt;/i&gt; (&lt;i&gt;DLG1&lt;/i&gt;) Revealed in a Murine Model of Pediatric B-ALL (2023)

&lt;p&gt;PDF file - 81K&lt;/p&gt;
CAMISIM: simulating metagenomes and microbial communities (2019)

CAMISIM can simulate a wide variety of microbial communities and metagenome data sets together with standards of truth for method evaluation. All data sets and the software are freely available at https://github.com/CAMI-challenge/CAMISIM.
Alteration of the Alkaloid Profile in Genetically Modified Tobacco Reveals a Role of Methylenetetrahydrofolate Reductase in Nicotine <i>N</i>-Demethylation    (2012)

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme of the tetrahydrofolate (THF)-mediated one-carbon (C1) metabolic network. This enzyme catalyzes the reduction of 5,10-methylene-THF to 5-methyl-THF. The latter donates its methyl group to homocysteine, forming methionine, which is then used for the synthesis of S-adenosyl-methionine, a universal methyl donor for numerous methylation reactions, to produce primary and secondary metabolites. Here, we demonstrate that manipulating tobacco (Nicotiana tabacum) MTHFR gene (NtMTHFR1) expression dramatically alters the alkaloid profile in transgenic tobacco plants by negatively regulating the expression of a secondary metabolic pathway nicotine N-demethylase gene, CYP82E4. Quantitative real-time polymerase chain reaction and alkaloid analyses revealed that reducing NtMTHFR expression by RNA interference dramatically induced CYP82E4 expression, resulting in higher nicotine-to-nornicotine conversion rates. Conversely, overexpressing NtMTHFR1 suppressed CYP82E4 expression, leading to lower nicotine-to-nornicotine conversion rates. However, the reduced expression of NtMTHFR did not affect the methionine and S-adenosyl-methionine levels in the knockdown lines. Our finding reveals a new regulatory role of NtMTHFR1 in nicotine N-demethylation and suggests that the negative regulation of CYP82E4 expression may serve to recruit methyl groups from nicotine into the C1 pool under C1-deficient conditions.