gebhart/patrepeval huggingface dataset:
Nuclear magnetic resonance studies of methylsilver(I) complexes (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNuclear magnetic resonance studies of methylsilver(I) complexesDavid E. Bergbreiter, T. J. Lynch, and Shogo ShimazuCite this: Organometallics 1983, 2, 10, 1354–1359Publication Date (Print):October 1, 1983Publication History Published online1 May 2002Published inissue 1 October 1983https://pubs.acs.org/doi/10.1021/om50004a017https://doi.org/10.1021/om50004a017research-articleACS PublicationsRequest reuse permissionsArticle Views166Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Engineered <i>s</i>‐Triazine‐Based Dendrimer‐Honokiol Conjugates as Targeted MMP‐2/9 Inhibitors for Halting Hepatocellular Carcinoma (2021)

Despite the advances in developing MMP-2/9 inhibitors, off-target side effects and pharmacokinetics problems remain major challenges hindering their clinical success in cancer therapy. However, recent targeting strategies have clearly revitalized MMP research. Herein, we introduce new s-triazine-based dendrimers endowed with intrinsic MMP-2/9 inhibitory potential and tetherable to hepatocellular carcinoma-specific targeting ligands and anticancer agents via biodegradable linkages for targeted therapy. The designed dendrimeric platform was built with potential zinc-binding branching linkers (hydrazides) and termini (carboxylic acids and hydrazides) to confer potency against MMP-2/9. Preliminary cytotoxicity screening and MMP-2/9 inhibition assay of the free dendrimers revealed promising potency (MMP-9; IC<sub>50</sub> =0.35-0.57 μM, MMP-2; IC<sub>50</sub> =0.39-0.77 μM) within their safe doses (EC<sub>100</sub> =94.15-42.75 μM). The hydrazide dendrimer was comparable to NNGH and superior to the carboxylic acid analogue. MTT assay showed that the free dendrimers were superior to the reference anticancer agent honokiol. Their anticancer potency was enhanced by HK conjugation, targeting ligands installation and PEGylation as exemplified by the hydrazide dendrimer conjugate (TPG<sub>3</sub> -NH<sub>2</sub> )-SuHK-FA-SuPEG (Huh-7; IC<sub>50</sub> =5.54 μM, HepG-2; IC<sub>50</sub> =10.07 μM) being 4 folds more active than HK, followed by the carboxylic acid conjugate (TPG<sub>3</sub> -OH)-HK-LA-PEG (Huh-7; IC<sub>50</sub> =14.97, HepG-2; IC<sub>50</sub> =21.29 μM). This was consistent with apoptosis studies.
Geometric algorithms for conflict detection/resolution in air traffic management (2002)

We consider the problems of conflict detection and resolution in air traffic management (ATM) from the perspective of computational geometry and give algorithms for solving these problems efficiently. For conflict resolution, we propose a simple method that can route multiple aircraft, conflict-free, through a cluttered airspace, using a prioritized routing scheme in space-time. Our algorithms have been implemented into a simulation system that tracks a large set of flights, having multiple conflicts, and proposes modified routes to resolve them. We report on the preliminary results from an extensive set of experiments that are under may to determine the effectiveness of our methods.
Self-Assembly of an Amphiphilic Siloxane Graft Copolymer in Water (2002)

The micelle formation and micelle structure of an amphiphilic poly(dimethylsiloxane)-graft-polyether copolymer in aqueous solution were investigated with a variety of experimental techniques. We measured the CMC by three different methodsDPH solubilization, methyl orange hypsochromic shift, and pyrene fluorescence I1/I3 ratio. The microviscosity was evaluated from DPH anisotropy values that were obtained by fluorescence polarization measurements. The microviscosity in the siloxane copolymer micelles was found lower than that in Pluronic block copolyether micelles. The micelle size and structure were obtained from small-angle neutron scattering (SANS) using the hard sphere model. The micelle hydrodynamic radius and the micelle size distribution were monitored by dynamic light scattering (DLS). The degree of hydration was estimated from a combination of DLS and SANS results. The temperature effect on CMC was found to be small; however, a structural transition of micelles from spheres to ellipsoids was observed by SANS at elevated temperature (60 °C).
Specification techniques for data abstractions (1975)

The main purposes in writing this paper are to discuss the importance of formal specifications and to survey a number of promising specification techniques. The role of formal specifications both in proofs of program correctness, and in programming methodologies leading to programs which are correct by construction, is explained. Some criteria are established for evaluating the practical potential of specification techniques. The importance of providing specifications at the right level of abstraction is discussed, and a particularly interesting class of specification techniques, those used to construct specifications of data abstractions, is identified. A number of specification techniques for describing data abstractions are surveyed and evaluated with respect to the criteria. Finally, directions for future research are indicated.
Supplemental Figure S6 from Disruption of Proline Synthesis in Melanoma Inhibits Protein Production Mediated by the GCN2 Pathway (2023)

&lt;p&gt;Supplemental Figure S6. P5CS protein knockdown did not consistently affect hydrogen peroxide or ROS levels.&lt;/p&gt;
Une approche innovante basée sur les réseaux de neurones pour prédire la variabilité des paramètres du sol (2002)

International audience
Targeting the PI3K/Akt/mTOR pathway with the pan-Akt inhibitor GDC-0068 in PIK3CA-mutant breast cancer brain metastases (2019)

This study suggests that the Akt inhibitor GDC-0068 may be an encouraging targeted treatment strategy for breast cancer brain metastasis patients with activating mutations in the PI3K pathway. These data provide a rationale to further evaluate the efficacy of GDC-0068 in patients with brain metastases.
&lt;title&gt;Color image watermarking using channel-state knowledge&lt;/title&gt; (2002)

This work concentrates on the problem of watermarking embedding and blind optimum detection in full-frame DCT domain using channel-state knowledge concepts. Minimum length sequences are used to embed the watermark information in the color components. Each chip of the sequence is inserted in a random-like fashion in those coefficients that ensure imperceptibility, robustness and a very low probability of error in detection. As it will be shown the power of the watermark has to be distributed among the symbols not only considering imperceptibility but also to improve the detection process. Furthermore, two solutions are proposed to improve the robustness against cropping operations.
Macular Pigment in Eyes With Macular Hole Formation and Its Change After Surgery (2020)

Observation of MP was useful for understanding the mechanisms of MH formation.
Giant and Tunneling Magnetoresistance in Unconventional Collinear Antiferromagnets with Nonrelativistic Spin-Momentum Coupling (2022)

Unconventional antiferromagnets exhibit spin-dependent ohmic and tunneling transport effects that are crucial for information readout in spintronics devices and that, so far, were reserved exclusively to ferromagnets.
Test and Evaluation of Black Swans in Early System Development for Maximum Effectiveness: A Case Study of Lightning Protection of Insensitive High Explosives. (2012)

Abstract not provided.
Optical Manipulation of Single Magnetic Beads in a Microwell Array on a Digital Microfluidic Chip (2016)

The detection of single molecules in magnetic microbead microwell array formats revolutionized the development of digital bioassays. However, retrieval of individual magnetic beads from these arrays has not been realized until now despite having great potential for studying captured targets at the individual level. In this paper, optical tweezers were implemented on a digital microfluidic platform for accurate manipulation of single magnetic beads seeded in a microwell array. Successful optical trapping of magnetic beads was found to be dependent on Brownian motion of the beads, suggesting a 99% chance of trapping a vibrating bead. A tailor-made experimental design was used to screen the effect of bead type, ionic buffer strength, surfactant type, and concentration on the Brownian activity of beads in microwells. With the optimal conditions, the manipulation of magnetic beads was demonstrated by their trapping, retrieving, transporting, and repositioning to a desired microwell on the array. The presented platform combines the strengths of digital microfluidics, digital bioassays, and optical tweezers, resulting in a powerful dynamic microwell array system for single molecule and single cell studies.
Nondeterminism and unification in LogScheme: integrating logic and functional programming (1989)

LogScheme is an experiment in adding the main features of logic programming, nondeterminism and unification, into the (mostly) functional language Scheme. We use a minimaliit approach, based on the observation that nondeterminism and unification are separable both in concept and in implementation.
Modeling the transition to fast mode streamers in dielectric liquids (2017)

A simplified model for photoionization, modeling fast streamer propagation, is combined with an existing model for slow streamers, based on electron avalanches. Transitions from fast mode to slow mode, and from slow mode to fast mode, are investigated.
Adaptive Minimax Regret against Smooth Logarithmic Losses over High-Dimensional $\ell_1$-Balls via Envelope Complexity (2018)

We develop a new theoretical framework, the \emph{envelope complexity}, to analyze the minimax regret with logarithmic loss functions and derive a Bayesian predictor that adaptively achieves the minimax regret over high-dimensional $\ell_1$-balls within a factor of two. The prior is newly derived for achieving the minimax regret and called the \emph{spike-and-tails~(ST) prior} as it looks like. The resulting regret bound is so simple that it is completely determined with the smoothness of the loss function and the radius of the balls except with logarithmic factors, and it has a generalized form of existing regret/risk bounds. In the preliminary experiment, we confirm that the ST prior outperforms the conventional minimax-regret prior under non-high-dimensional asymptotics.
Epidemiology, assessment, and management of excess abdominal fat in persons with HIV infection. (2010)

Metabolic and morphologic abnormalities in persons with HIV remain common contributors to stigma and morbidity. Increased abdominal circumference and visceral adiposity were first recognized in the late 1990s, soon after the advent of effective combination antiretroviral therapy. Visceral adiposity is commonly associated with metabolic abnormalities including low HDL-cholesterol, raised triglycerides, insulin resistance, and hypertension, a constellation of risk factors for cardiovascular disease and diabetes mellitus known as "the metabolic syndrome". Medline and conference abstracts were searched to identify clinical research on factors associated with visceral adiposity and randomized studies of management approaches. Data were critically reviewed by physicians familiar with the field. A range of host and lifestyle factors as well as antiretroviral drug choice were associated with increased visceral adiposity. Management approaches included treatment switching and metformin, both of which have shown benefit for insulin-resistant individuals with isolated fat accumulation. Testosterone supplements may also have benefits in a subset of individuals. Supra-physiological doses of recombinant human growth hormone and the growth hormone releasing hormone analog tesamorelin both significantly and selectively reduce visceral fat over 12-24 weeks; however, the benefits are only maintained if doping is continued. In summary, the prevention and management of visceral adiposity remains a substantial challenge in clinical practice.
Unambiguous determination of the wave impedance (2017)

The unambiguous determination of the wave impedance is offered and approved in this paper. It is shown that in the case of slow-wave structures, the wave impedance ambiguity is caused by the longitudinal capacitive currents. They decrease the effective value of the voltage applied to the conduction current in the impedance electrode. This is followed by the decrease in the real power flow and leads to the ambiguous determination of the wave impedance by the conventional formulas of the circuit theory.
Existence theorems, lower bounds and algorithms for scheduling to meet two objectives (2002)

We give general results about the existence of schedules which simultaneously minimize two criteria. Our results are general in that (i) they apply to any scheduling environment and (ii) they apply to all pairs of metrics in which the first metric is one of maximum flow time, makespan, or maximum lateness and the second metric is one of average flow time, average completion time, average lateness, or number of on-time jobs. For most of the pairs of metrics we consider, we show the existence of near-optimal schedules for both metrics as well as some lower bound results. For some pairs of metrics such as (maximum flow time, average weighted flow time) and (maximum flow time, number of on-time jobs), we prove negative results on the ability to approximate both criteria within a constant factor of optimal. For many other criteria we present lower bounds that match or approach our bicriterion existence results.
Pseudomorphic and Metamorphic Quantum Dot Heterostructures for Long-Wavelength Lasers on GaAs and Si (2008)

We have investigated the design, molecular beam epitaxial growth, and fundamental characteristics of pseudomorphic and metamorphic quantum dot laser heterostructures on GaAs and Si. By utilizing the special techniques of low-temperature growth and in situ thermal annealing and carefully controlling various growth parameters, we have achieved 1.3-1.55-mum pseudomorphic and metamorphic quantum dot heterostructures on GaAs that exhibit superior optical quality. The special techniques of p-doping and tunnel injection have also been explored in the design and growth of quantum dot laser heterostructures, leading to long-wavelength lasers on GaAs that exhibit, for the first time, ultralow threshold current (J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> = 63 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), nearly temperature-invariant operation (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> ap infin), large modulation bandwidth (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sub> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">dB</sub> = 11 GHz), near-zero alpha-parameter, and very small chirp (les0.2 A). With the incorporation of multiple layers of InAs quantum dots as effective three-dimensional dislocation filters, we have demonstrated the first room-temperature operational quantum dot lasers on Si that exhibit relatively low threshold current (J <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> = 900 A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) and very high temperature stability (T <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sub> = 244 K).
Insulin-like growth factor I regulates renal development in rodents (1999)

Blocking the action of insulin-like growth factor I (IGF I) impairs kidney development in vitro. However, no renal developmental abnormalities have been reported in newborn transgenic mice that do not express IGF I (Igf1-/-) mice. Ninety-five percent of Igf1-/- mice die immediately following birth. Kidney development continues following birth in rodents. To readdress the question of the participation of IGF I in the process of kidney development, we measured nephron numbers in developed kidneys from Igf1-/- mice that survived past birth, and using a second model of kidney development, characterized the effect of IGF I infused into rat hosts on the renal function of transplanted metanephroi. Igf1-/- mice were born with grossly normal kidneys. At 77 +/- 10 days after birth, Igf1-/- mice that survived were approximately 28% the weight of wild-type (WT) littermates and had proportionally smaller kidneys. The number of nephrons per kidney was reduced by approximately 20% in Igf1-/- mice. Glomerular size was also reduced in Igf1-/- mice. In untreated host rats, neither the size nor inulin clearance of transplanted metanephroi changed significantly from 12-28 weeks postimplantation. The administration of IGF I to hosts did not affect the size of transplanted metanephroi measured at 12-16 weeks following implantation. However, inulin clearances were increased significantly by the administration of IGF I to hosts. Our findings 1) indicate that IGF I plays a role in determining nephron number, 2) suggest that it enhances function in developing kidneys, and 3) establish the potential for the pharmacological use of IGF I to enhance the growth and function of transplanted metanephroi.
Profiling acylated homoserine lactones in Yersinia ruckeri and influence of exogenous acyl homoserine lactones and known quorum-sensing inhibitors on protease production (2006)

The array of different AHLs produced indicates that the QS system of Y. ruckeri is complex and could involve several regulatory systems. In this case, neither AHLs nor QSI would be likely to directly affect a QS-regulated phenotype.
Design methodology of refractive index engineering by implantation of high-energy particles in electro-optic materials (2007)

Slab waveguides were constructed in K(1-x)Li(x)Ta(1-y)Nb(y)O(3) crystals by the implantation of (12)C(+4) ions at 30 MeV and (16)O(+5) ions at 30 and 40 MeV. The waveguides were characterized by a prism coupler setup. A refractive index drop of 10.9% was observed in a layer formed by the implantation of (16)O(+5) ions at 30 MeV. The carbon-implanted waveguides were found to be thermally stable after annealing at 450 degrees C. A semiempirical formula for predicting the change in the refractive index given the parameters of the implantation process was developed. It is argued that the combination of the basic implantation process with the semiempirical formula can be developed to become a generic method for constructing complex electro-optic circuits with a wave-guided architecture.
Roles of Education and IQ in Cognitive Reserve in Parkinson’s Disease-Mild Cognitive Impairment (2012)

The association of higher IQ and decreased odds of PD-MCI supports a role for cognitive reserve in PD, but further studies are needed to clarify the interaction of IQ and education and the impact of other contributors such as employment and hobbies.
Yagi–Uda Antenna (2005)

Abstract The Yagi–Uda antenna is one of the most practical and commonly used antennas. It features high gain and low weight and profile, and is inexpensive to manufacture. In this article, the fundamental operation of the Yagi–Uda is discussed, as well as a classic graphical technique for obtaining a fixed gain design. Several modern versions of the Yagi–Uda antenna are also described that permit operation of the antenna at microwave frequencies and allow for simple integration into planar arrays.
Rechargeable Zn–Air Batteries Enabled By Zn Sponge Anodes and Bi(tri?)Functional Cathodes (2017)

Zinc–air batteries have the potential to overcome many of the disadvantages of current Li-ion batteries: safety concerns associated with toxic and flammable electrolytes, high costs, and specific energy &lt;200 Wh kg –1 . Zinc–air provides higher specific energy (up to 450 Wh kg –1 ), while using safe, low-cost components and aqueous electrolytes. Although commercially successful as a primary battery, broader implementation of Zn–air batteries is hindered by limited rechargeability and modest zinc utilization (typically &lt;60% of theoretical discharge capacity). This long-standing performance roadblock is attributed to the manner in which Zn electrodes are commonly fabricated—by mixing Zn powder with binders and gelling agents to form composite electrodes. During discharge of these ad hoc structures, Zn is oxidized and forms soluble zincate, which diffuses from its point of electrogeneration until it supersaturates and then dehydrates to high-impedance products (e.g., ZnO). Upon electrochemical recharge, ZnO, in equilibrium with soluble zincate, is reduced back to Zn 0 , often accompanied by a shape change. Discharge–charge cycling leads to pronounced morphological changes, especially at points of high local current density, where short-inducing dendrites can form. We developed a Zn “sponge” form factor comprising interpenetrating, co-continuous networks of solid and void which imposes more uniform current distribution throughout the volume of the electrode structure, minimizes uneven reaction loci, and suppresses formation of dendrites. We have demonstrated that the Zn sponge electrode can be cycled in prototype Ag–Zn and Ni–Zn cells without the formation of dendrites, but translating that to the Zn–air case requires the use of air-cathodes that also support electrochemical discharge and recharge. For that more ambitious cell chemistry, we turn to powder-composite air cathodes that include mesoporous oxides of manganese and/or a solid-solution or mixed-phase oxides of transition metals such as nickel and/or iron prepared via sol–gel synthetic methods. Zinc–air cells were constructed and cycled at high depths-of-discharge relative to the Zn, an achievement that not only validates the ability for the air cathode to be bifunctionally catalyzed, but to operate at capacities and rates that turn all of the Zn in the anode over enough times to generate a technologically relevant specific energy.