gebhart/patrepeval huggingface dataset:
P3–392: p24 family proteins have different function in APP processing (2006)

Presenilin complexes with gamma–secretase activities consist of at least four proteins, presenilin, nicastrin, Aph–1 and PEN–2. Transfection of these four proteins reconstitute gamma–secretase activities, but presenilin complexes cleave lots of type I membrane proteins as a substrate and are responsible to at least two independent cleavages in the transmembrane domain of APP. Thus, it might be possible that there is a regulatory mechanism in substrate specificity and cleavage–site control. Recently, we identified a novel associating protein that modulates APP processing. Identified protein is one of the members of p24 family. p24 family proteins work as hetero–oligomer in the vesicular trafficking machinery in the early secretary pathway. We investigated whether the modulation of gamma–secretase activities is a common function in p24 family in order to clarify the mechanism, although any other p24 family was not detected in the initial protein interaction screening. Another p24 family protein whose homologous protein, sel–9, was reported to modify mutant Notch signal pathway in C. elegans. was analyzed in HEK293 cells. The interaction with the components of presenilin complexes, was studied by immunoprecipitation. The effect of overexpression or knock–down on gamma– and epsilon–secretase activities was assessed in whole cell and in vitro assay. In addition, Notch S3 cleavage was analyzed by metabolic labeling. Endogenous p24 family protein corresponding to sel–9 did not pull–down any components in presenilin complexes, different from another p24 protein identified as a modulator of APP processing, while apparent interaction between p24 family proteins was detected as reported previously. Neither overexpression nor knock–down of sel–9 homologous protein has any effect on Abeta or AICD production at least in endogenous and Swedish mutant APP. In addition, no significant difference in wild–type Notch S3 cleavage was observed. One of the explanations of this discrepancy between human and C. elegans is that Sel–9 in C. elegans might affect just mutant Notch through quality control mechanism. Besides, these results also revealed that p24 protein identified as a modulator of APP processing has a clearly different function from the other members in APP processing.
&lt;title&gt;Optical fiber amplifier technologies for next-generation WDM transmissions&lt;/title&gt; (2001)

Optical amplifiers are demanded to improve their performances in order to support the forthcoming Internet oriented WDM networks. This paper reviews recent topics on next generation optical fiber amplifier technologies developed at author's research group.
Carboxypeptidase E (enkephalin convertase): mRNA distribution in rat brain by in situ hybridization (1990)

Carboxypeptidase E (CPE), also referred to as enkephalin convertase or carboxypeptidase H (EC 3.4.17.10), is present in neurotransmitter secretory granules and can remove C-terminal basic residues following endopeptidase cleavage during peptide processing. Using in situ hybridization with 35S-labeled oligonucleotide probes, we have mapped the localization of CPE mRNA in the rat brain. Specificity for CPE was confirmed by control experiments, which included production of identical patterns hybridization with 3 different antisense oligonucleotide probes, loss of label with RNase pretreatment of sections or co-incubation with excess unlabeled probe, and lack of labeling with sense orientation probes. In addition, the regional distribution of CPE mRNA by Northern blot analysis corresponded with distribution of labeling by in situ hybridization. The highest levels of CPE mRNA were found to be present in the pyramidal cells of the hippocampus, the pituitary anterior and intermediate lobes, the ependymal cells of the lateral ventricle, the endopiriform nucleus, the basolateral amygdala, the supraoptic nucleus, and the paraventricular nucleus. Intermediate levels were present in the thalamus, medial geniculate nucleus, lateral septal nucleus, piriform and entorhinal cortex, nucleus of the tractus solitarius, cerebellar cortex, pontine nuclei, and inferior olive. The lowest levels were found in the hippocampal granule cell layer, lateral hypothalamus, globus pallidus, and brain stem reticular formation. Ibotenic acid lesions of the hippocampus eliminated the majority of the label, which had been present over pyramidal cells, though labeling was increased over areas of reactive gliosis, suggesting that activated astrocytes can also synthesize CPE mRNA. In general, the localization of CPE mRNA in the rat brain corresponded to the distribution of enkephalin and other peptide neurotransmitter-synthesizing neurons, though CPE mRNA was also present in neurons that do not secrete known peptides and in reactive glia. The widespread yet specific localization of CPE mRNA in the rat brain suggests it may be an excellent marker for peptide synthesizing cells in the CNS.
Premartensitic elastic shear anisotropy in fee alloys (1994)

The fcc→fct pretransitional “elastic” behavior of In-Tl, In-Cd and Fe-Pd alloys has been investigated using a low-frequency, 100 Hz to 104 Hz, resonance method and transmission electron microscopy. Both shear coefficients, C′ and C44, were observed to decrease almost linearly as the temperature approaches the martensitic transformation temperature and C44 is frequency dependent. The electron microscopic investigations confirmed the diffuse streaking in directions and revealed a strain modulation at 1/4 . The results of the mechanical response and the structural studies complement each other. It is proposed that the unusual low frequency premartensitic shear behavior represents dynamic and reversible {111} twinning on a very fine scale.
Synthesis of .beta.-oxopropyl esters by catalytic addition of carboxylic acids and N-protected amino acids to propargyl alcohol (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis of .beta.-oxopropyl esters by catalytic addition of carboxylic acids and N-protected amino acids to propargyl alcoholDominique Devanne, Christophe Ruppin, and Pierre H. DixneufCite this: J. Org. Chem. 1988, 53, 4, 925–926Publication Date (Print):February 1, 1988Publication History Published online1 May 2002Published inissue 1 February 1988https://pubs.acs.org/doi/10.1021/jo00239a059https://doi.org/10.1021/jo00239a059research-articleACS PublicationsRequest reuse permissionsArticle Views374Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
&lt;title&gt;Image retrieval and reversible illumination normalization&lt;/title&gt; (2005)

We propose a novel approach to retrieve similar images from image databases that works in the presence of significant illumination variations. The most common method to compensate for illumination changes is to perform color normalization. The existing approaches to color normalization tend to destroy image content in that they map distinct color values to identical color values in the transformed color space. From the mathematical point of view, the normalization transformation is not reversible. In this paper we propose to use a reversible illumination normalization transformation. Thus, we are able to compensate for illumination changes without any reduction of content information. Since natural illumination changes affect different parts of images in different amounts, we apply our transformation locally to sub-images. Basic idea is to divide an image into sub-images, normalize each one separately, and then project it to an <i>n</i>-dimensional reduced space using principal component analysis. This process yields a normalized texture representation as a set of <i>n</i>-vectors. Finding similar images is now reduced to computing distances between sets of <i>n</i>-vectors. Results were compared with a leading image retrieval system.
Multitarget Tracking with Transformers (2021)

Multitarget Tracking (MTT) is the problem of tracking the states of an
unknown number of objects using noisy measurements, with important applications
to autonomous driving, surveillance, robotics, and others. In the model-based
Bayesian setting, there are conjugate priors that enable us to express the
multi-object posterior in closed form, which could theoretically provide
Bayes-optimal estimates. However, the posterior involves a super-exponential
growth of the number of hypotheses over time, forcing state-of-the-art methods
to resort to approximations for remaining tractable, which can impact their
performance in complex scenarios. Model-free methods based on deep-learning
provide an attractive alternative, as they can in principle learn the optimal
filter from data, but to the best of our knowledge were never compared to
current state-of-the-art Bayesian filters, specially not in contexts where
accurate models are available. In this paper, we propose a high-performing
deep-learning method for MTT based on the Transformer architecture and compare
it to two state-of-the-art Bayesian filters, in a setting where we assume the
correct model is provided. Although this gives an edge to the model-based
filters, it also allows us to generate unlimited training data. We show that
the proposed model outperforms state-of-the-art Bayesian filters in complex
scenarios, while macthing their performance in simpler cases, which validates
the applicability of deep-learning also in the model-based regime. The code for
all our implementations is made available at (github link to be provided).
On‐Chip Micro‐Pseudocapacitors for Ultrahigh Energy and Power Delivery (2015)

<b>Microscale supercapapcitors</b> based on hierarchical nanoporous hybrid electrodes consisting of 3D bicontinuous nanoporous gold and pseudocapacitive manganese oxide deliver an excellent stack capacitance of 99.1 F cm<sup>-3</sup> and a high energy density of 12.7 mW h cm<sup>-3</sup> with a retained high power density of 46.6 W cm<sup>-3</sup>.
Towards large-scale co-production of electricity and hydrogen via decarbonisation of fossil fuels combined with CCS (geological storage) (2009)

This paper deals with recent assessments and results of the EU-based DYNAMIS 1 project, which - since March 2006 - has been investigating decarbonisation of fossil fuels (bituminous coal, lignite and natural gas), with the inclusion of carbon capture and geological storage of the CO2 (CCS). The project was established by leading European RTD providers and industries, and sponsored by the European Commission under its 6th Framework Programme. Main deliverables of the DYNAMIS project comprise pre-engineering studies and a subset of recommendations to the European Commission with regards to its HYPOGEN Demonstrator Programme. According to prerequisites established by the European Commission, the HYPOGEN Demonstrator is planned to offer electricity, hydrogen and CO2 at large scale - scheduled for commercial operations to commence by 2012–2015.
Optimizing the computation of n-point correlations on large-scale astronomical data (2012)

The n-point correlation functions (npcf) are powerful statistics that are widely used for data analyses in astronomy and other fields. These statistics have played a crucial role in fundamental physical breakthroughs, including the discovery of dark energy. Unfortunately, directly computing the npcf at a single value requires O(N <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sup> ) time for N points and values of n of 2, 3, 4, or even larger. Astronomical data sets can contain billions of points, and the next generation of surveys will generate terabytes of data per night. To meet these computational demands, we present a highly-tuned npcf computation code that show an order-of-magnitude speedup over current state-of-the-art. This enables a much larger 3-point correlation computation on the galaxy distribution than was previously possible. We show a detailed performance evaluation on many different architectures.
Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study (2016)

Hepatocellular carcinoma (HCC) is a leading cause of cancer death worldwide; its incidence is increasing in the United States. Depending on disease extent and underlying liver status, patients may be treated with local, locoregional, and/or systemic therapy. Recent data indicates that radiotherapy (RT) can play a meaningful role in the management of HCC. Here, we review published experiences using RT for HCC, including the use of radiosensitizers and stereotactic RT. We discuss methods for performing preclinical studies of RT for HCC and biomarkers of response. As a part of the HCC Working Group, an informal committee of the National Cancer Institute's Radiation Research Program, we suggest how RT should be implemented in the management of HCC and identify future directions for the study of RT in HCC.
Design of UWB filter using DGS and Slot SRR array with band rejection for IEEE 802.11a WLAN (2011)

In this paper an ultra-wideband filter is designed using periodic defected ground structures as low pass filter and Slot SRRs in the conducting strip as a band reject filter to prevent interference from WLAN. The high pass characteristic is obtained by an interdigital capacitor in the conducting strip. The average insertion loss is 1.6 dB in the passband. The band stop filter rejects frequencies from 5.21 GHz to 5.9 GHz with maximum rejection being −33.46 dB at 5.4 GHz and stopband rejection is upto −68.61 dB and −60dB in the upper and lower stop-bands respectively.
Assessment of Seedling Parameters and Biochemical Composition of Maize (Zea mays L.) by Soaking Process (2020)

Maize is one of the most versatile emerging crops having wider adaptability. Globally, maize is known as “QUEEN OF CEREALS” because of its highest genetic yield potential India is the fifth largest producer of maize in the world contributing 3 percent of the global production. Hereby study was conducted in a completely randomized design with four replications in controlled conditions at Department of Genetics and Plant Breeding, SHUATS, Prayagraj (U.P) during 2018-2020, to assess the effect of pre sowing seed treatments on germination, seedling vigour, germination energy and protein in Maize. Inorganic and organic priming methods were adopted and treatments used are as T0 (Control), T1-KNO3 (2%), T2- SA (100 ppm), T3- PEG6000(15%),T4- CaCl2 (2%), T5- IAA (100ppm), T6- Neem leaf extract (5%), T7- Mint leaf extract (5%), T8- Moringa leaf extract(5%), T9- Curry leaf extract (5%), T10- Aloe vera leaf extract (5%). It was found that all the treatments showed significant effect on seed quality parameters. The highest germination percentage (%), germination energy, seedling length (cm), seedling fresh weight (g), seedling dry weight (g), and vigour indices were observed in treatment T3-PEG6000 (5%) priming for 12 hours. This study revealed that Pre-sowing seed treatment with PEG6000 enhance germinability and seedling character in Maize, its simplicity and no requirement for expensive equipment and chemical could be used as a simple method for overcoming related to a poor germination and seedling establishment. Results also indicates that priming method had little influence on protein content of maize seeds.
Current challenges in the management of patients with relapsed/refractory multiple myeloma. (2011)

When treating patients with relapsed/refractory multiple myeloma, clinicians should maximize the efficacy of treatment through use of the most appropriate combinations and sequences of agents. Treatment options depend on the duration and magnitude of response to previous therapies; the type and aggressiveness of the relapse; and patient factors such as comorbidities, performance status/quality of life, bone marrow reserve, renal function, previous toxicities (eg, peripheral neuropathy, venous thromboembolism), age, insurance coverage, distance from the hospital, and life expectancy. Patients who relapse within 1 year of a stem-cell transplant (SCT) may require multidrug rescue therapy, followed by allogeneic SCT with reduced-intensity conditioning or consolidation/maintenance therapy. Those with a long duration of remission (3 to 4 years) may undergo a second autologous SCT, using the original effective treatment protocol or a different combination as reinduction. Patients with intermediate remission duration (2 to 3 years) may benefit from the sequential use of novel agents as salvage therapy. In elderly patients, considerations of quality of life and cost constraints should be carefully weighed. At first relapse, the initial option would be to use a new scheme that is different from the one used for induction, unless the first remission was long enough to merit considering retreatment with the same scheme. At second or subsequent relapse, usually after having been treated with bortezomib (Velcade) and at least one immunomodulatory drug, enrollment in a clinical trial with experimental agents should be encouraged. This article describes the current evidence available for various treatment options as well as a personal approach to individualized therapy for relapsing patients.
Towards a clinically useful sonic flashlight (2003)

We have previously shown a new method of merging a direct view of the patient with an ultrasound image displayed in situ within the patient, using a half-silvered mirror. We call this method Real Time Tomographic Reflection (RTTR). This paper reviews our progress to date in developing an embodiment of RTTR that we call the sonic flashlight/spl trade/. The clinical utility of the sonic flashlight for guiding invasive procedures will depend on a number of factors, and we have explored these factors through a series of prototypes. Responding to feedback from our clinical collaborators, we have upgraded various elements of our original apparatus and implemented a new generation of the system that is smaller, lighter, and more easily manipulated. We have improved performance as we gain a better understanding of the optical parameters of the system. Our results demonstrate in situ visualization of vasculature of the neck in a human volunteer and the anatomy of the eye in a cadaver.
["ARCHIDIA": a system for patients' data collection and computerized filing. Part I. Methodology]. (1994)

This report describes a computer based program of patient clinical data collection: the ARCHIDIA system. The project relies on descriptive analysis of clinical events according to well defined methodological criteria. This allows the formulation of a concise diagnosis which is, at the same time, exhaustive of all essential information. Two are the basis principles of this methodology: To define, as accurately as possible, the logical steps necessary to elaborate the diagnosis, that is construed by a sequence of codes. To define all the conditions that must be followed so to use any code in a controlled and independent way. These criteria were derived from literature. The major claim of the system is likely to be the introduction of a "common language" between different ICUs. Uniformed diagnostic and clinical criteria are the main source of large data collection for descriptive, analytic and prospective studies. After a one year pilot study performed by 4 ICUs, ARCHIDIA was used, in 1991, by 20 centers from the area of Milan, Pavia, Como, Varese (70% of total) and 4148 patient data were collected. A descriptive analysis will be reported in the following paper.
Enhancement of Structural, Electrochemical, and Thermal Properties of High-Energy Density Ni-Rich LiNi<sub>0.85</sub>Co<sub>0.1</sub>Mn<sub>0.05</sub>O<sub>2</sub> Cathode Materials for Li-Ion Batteries by Niobium Doping (2021)

Ni-rich layered oxide LiNi<sub>1 - <i>x</i> - <i>y</i></sub>Co<i><sub>x</sub></i>Mn<i><sub>y</sub></i>O<sub>2</sub> (1 - <i>x</i> - <i>y</i> > 0.5) materials are favorable cathode materials in advanced Li-ion batteries for electromobility applications because of their high initial discharge capacity. However, they suffer from poor cycling stability because of the formation of cracks in their particles during operation. Here, we present improved structural stability, electrochemical performance, and thermal durability of LiNi<sub>0.85</sub>Co<sub>0.1</sub>Mn<sub>0.05</sub>O<sub>2</sub>(NCM85). The Nb-doped cathode material, Li(Ni<sub>0.85</sub>Co<sub>0.1</sub>Mn<sub>0.05</sub>)<sub>0.997</sub>Nb<sub>0.003</sub>O<sub>2</sub>, has enhanced cycling stability at different temperatures, outstanding capacity retention, improved performance at high discharge rates, and a better thermal stability compared to the undoped cathode material. The high electrochemical performance of the doped material is directly related to the structural stability of the cathode particles. We further propose that Nb-doping in NCM85 improves material stability because of partial reduction of the amount of Jahn-Teller active Ni<sup>3+</sup> ions and formation of strong bonds between the dopant and the oxygen ions, based on density functional theory calculations. Structural studies of the cycled cathodes reveal that doping with niobium suppresses the formation of cracks during cycling, which are abundant in the undoped cycled material particles. The Nb-doped NCM85 cathode material also displayed superior thermal characteristics. The coherence between the improved electrochemical, structural, and thermal properties of the doped material is discussed and emphasized.
Formation of Large Unilamellar Vesicles by Extrusion (2018)

The sequential passage of liposomes through ﬁlters of a deﬁned pore size to generate large unilamellar vesicles (LUV) with a mean diameter reﬂecting the diameter of the ﬁlter pore was ﬁrst described 25 years ago (1). In the 1970s, making LUV was an arduous process, often taking several days and severely limiting the rate at which some areas of model membrane research could advance. However, this changed in the mid-1980s with the introduction of robust, practical, high-pressure equipment that greatly simpliﬁed LUV production (2). Using the devices described in this chapter, extrusion can be applied to a wide variety of lipid species and mixtures, it works directly from multilamellar vesicles (MLV) without the need for sequential size reduction, process times are on the order of minutes, and it is only marginally limited by lipid concentration compared to other methods. Manufacturing issues related to the removal of organic solvents or detergents from ﬁnal preparations are eliminated and the equipment has been scaled for bench volumes (0.1-10mL) through to preclinical (10mL-1L) and clinical (&gt;1L) applications employing relatively low-cost equipment, especially at the research and preclinical levels (3).