1387 EFFECT OF REPEATED PROSTATE BIOPSIES ON ERECTILE FUNCTION IN MEN UNDER ACTIVE SURVEILLANCE FOR PROSTATE CANCER (2012)

You have accessJournal of UrologySexual Function/Dysfunction/Andrology: Evaluation II1 Apr 20121387 EFFECT OF REPEATED PROSTATE BIOPSIES ON ERECTILE FUNCTION IN MEN UNDER ACTIVE SURVEILLANCE FOR PROSTATE CANCER Katharina Braun, Youness Ahallal, Tarek P. Ghoneim, Mario Esteban, Daniel Sjoberg, Melanie Bernstein, Andrew J. Vickers, John P. Mulhall, James A. Eastham, Peter T. Scardino, and Karim A. Touijer Katharina BraunKatharina Braun New York, NY More articles by this author , Youness AhallalYouness Ahallal New York, NY More articles by this author , Tarek P. GhoneimTarek P. Ghoneim New York, NY More articles by this author , Mario EstebanMario Esteban New York, NY More articles by this author , Daniel SjobergDaniel Sjoberg New York, NY More articles by this author , Melanie BernsteinMelanie Bernstein New York, NY More articles by this author , Andrew J. VickersAndrew J. Vickers New York, NY More articles by this author , John P. MulhallJohn P. Mulhall New York, NY More articles by this author , James A. EasthamJames A. Eastham New York, NY More articles by this author , Peter T. ScardinoPeter T. Scardino New York, NY More articles by this author , and Karim A. TouijerKarim A. Touijer New York, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1814AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Active Surveillance (AS) for low grade prostate cancer is becoming more common in clinical practice. This management strategy involves repeated prostate biopsies over time. It has been hypothesized that serial biopsies can lead to reduced erectile function (EF). We aimed to explore this hypothesis in a cohort at Memorial Sloan-Kettering Cancer Center (MSKCC). METHODS We identified a cohort of 352 men on AS at MSKCC whose first biopsy occurred between 2000 and 2009. These men provided more than 1500 reports of EF while on AS. We investigated the trend in EF while on AS using both patient-reported and surgeon-graded EF. A lowess smoother was utilized to estimate the change in EF over time. We tested for a time trend in EF using generalized estimating equations (GEE) approach. RESULTS The median age (IQR) in this cohort was 64 years (58-69). The median time of follow-up on AS was 2.4 years (0.8-3.9) and the median number of biopsies was 3 (2-4). While EF did diminish over time (p<0.001), the decline was very small: 0.8 points / year on the patient-reported QOL scale (scale 1-30) and 0.1 points / year for surgeon grade (scale 1-5). CONCLUSIONS We observed a small decline over time in the EF of men on active surveillance. The decrease in EF seem broadly comparable to that which might be expected from the normal aging process. While we cannot separate out the effect of multiple biopsies on EF in this observational study, it does not seem plausible that AS-related biopsies have a large impact on EF. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e563 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Katharina Braun New York, NY More articles by this author Youness Ahallal New York, NY More articles by this author Tarek P. Ghoneim New York, NY More articles by this author Mario Esteban New York, NY More articles by this author Daniel Sjoberg New York, NY More articles by this author Melanie Bernstein New York, NY More articles by this author Andrew J. Vickers New York, NY More articles by this author John P. Mulhall New York, NY More articles by this author James A. Eastham New York, NY More articles by this author Peter T. Scardino New York, NY More articles by this author Karim A. Touijer New York, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...