gebhart/patrepeval huggingface dataset:
Cyclic Deformation of Powder Metallurgy Stainless Steel/Mg‐PSZ Composite Materials (2012)

Abstract In this study, the low‐cycle fatigue (LCF) behavior of powder metallurgy stainless steel/MgO partially stabilized zirconia (Mg‐PSZ) composite materials is presented. The steel matrix based on conventional AISI 304 steel (1.4301) is reinforced with Mg‐PSZ. The investigated composite materials were manufactured using the spark plasma sintering (SPS) technique. Total strain‐controlled LCF tests were performed on materials containing 0, 5, and 10 vol% Mg‐PSZ, respectively, in order to evaluate the influence of the ceramic reinforcement. Electron backscatter diffraction (EBSD) measurements were applied to identify the locations where the martensitic phase transformations in the steel matrix and stress‐assisted as well as athermal martensitic phase transformations of the Mg‐PSZ ceramic reinforcement take place. The resulting cyclic deformation behavior is correlated with the microstructural features of the composite material.
Global PRoMiSe (Perioperative Recommendations for Medication Safety): protocol for a mixed-methods study (2020)

NCT04240301.
Preliminary evaluation of selected aptamers against hantaviruse (2019)

Hantavirus is a zoonotic, viral respiratory disease and is recent associated with human diseases that need a qualitative diagnosis method to promote a rational treatment as well as controlling the spread ability of the virus. Thus a early rational treatment is necessary in the outcome of the disease that on a identification etiological agent is essential. This paper shows results obtained from hantavirus aptamers interaction with the hantavirus protein, ANDES solution, throw fluorometric methods, that will assist in the determination of a secure path to aim an identification mechanism to identify the virus. The investigation revels that aptamer C2526 shows a high affinity binding with hantavirus protein, ANDES, being a promise reactive for recognizing assays.
Copper‐Catalyzed Synthesis of γ‐Amino Acids Featuring Quaternary Stereocenters (2017)

Abstract The first general asymmetric synthesis of γ,γ‐disubstituted γ‐amino acids by copper‐catalyzed ring opening of nonstrained lactones with amines is reported. This approach features ample scope, operational simplicity, and wide functional‐group diversity. The catalytic process allows access to a series of highly functionalized enantioenriched γ‐amino acids featuring quaternary stereocenters with excellent enantiomeric ratios of up to 98:2 and excellent yields of up to 98 %.
Liquid biopsy in newly diagnosed patients with locoregional (I-IIIA) non-small cell lung cancer (2019)

Liquid biopsy is a promising method for the management of lung cancer, but previous studies focused mainly on patients with advanced-stage disease. As the methodology has progressed for the detection of circulating tumor DNA (ctDNA) and its aberrant methylation, researchers are gradually investigating the utility of liquid biopsy in early-stage patients. As a result, liquid biopsy has shown its potential for the application in patients with early- and locally advanced-stage non-small cell lung cancer (NSCLC). Areas covered: This review summarizes the utility of liquid biopsy in NSCLC and provide an outlook for future development. We focus on the role of ctDNA and its aberrant methylation in patients with stage IA to stageⅢA NSCLC, in the field of early detection and screening, perioperative management, and postoperative surveillance. Expert opinion: Liquid biopsy has shown the potential for clinical application of early-stage patients but has not been routinely applied yet. The utilization of liquid biopsy will be promoted by improved detection methods and data from well-designed clinical trials. With the development of precision medicine, liquid biopsy will likely play an increasingly important clinical role.
An Approach to Controlling Swarms of Unmanned Aerial Vehicles in Adversarial Situations (2006)

Over the past years, the autonomy and reliability of Unmanned Aerial Vehicles (UAVs) has been improved significantly. It is generally acknowledged that their eventual utility in a battlefield or commercial environment will require multiple vehicles cooperating to achieve specific mission objectives. This paper introduces a differential game approach to control a swarm of UAVs. The approach decomposes the complete problem of controlling the entire swarm of UAVs simultaneously into a collection of smaller differential game problems that are easier to solve. Based on the solution to the individual games, a planner assigns tasks for each U A V to perform taking advantage of the vehicles’ current positions and their capabilities. A simple example is used to demonstrate the effectiveness and speed of this approach while some implementation issues are also discussed.
Prática profissional de professores dos anos iniciais e o pensamento algébrico: contribuições a partir de uma formação continuada&lt;br&gt;Teachers’ Professional Practice in Early Years and Algebraic Thinking: Contributions from In-Service Training (2021)

ResumoNeste artigo analisamos como dois professores dos anos iniciais do ensino fundamental planejaram e conduziram uma aula considerando aspectos do pensamento algébrico a partir de uma abordagem de ensino exploratório, tendo em conta sua participação em uma formação continuada. O estudo enquadra-se em uma perspectiva qualitativa-interpretativa de pesquisa, em que a recolha de dados foi proveniente do planejamento dos professores, de registros em áudio das aulas, com sua subsequente transcrição, e registro fotográfico das tarefas matemáticas realizadas pelos alunos. Os resultados mostram que como consequência da formação realizada, as ações de planejamento e condução das aulas dos professores consideraram as fases do ensino exploratório, bem como aspectos do pensamento algébrico.Palavras-chave: Pensamento algébrico, Prática profissional, Ensino exploratório, Anos iniciais, Formação continuada.AbstractThis article analyses how two teachers of the early years of elementary school planned and conducted a class considering aspects of algebraic thinking from an exploratory teaching approach, taking into account their participation in continuing education. The study fits into a qualitative-interpretative research perspective, in which the data collection came from the teachers' planning, from audio records of the classes, with their subsequent transcription, and photographic record of the mathematical tasks performed by the students. The results show that as a consequence of the training carried out, the actions of planning and conducting the teachers' classes considered the phases of exploratory teaching, as well as aspects of algebraic thinking.Keywords: Algebraic thinking; Professional practice; Exploratory teaching approach; Early years; In-service training.ResumenEste artículo analiza cómo dos profesores de los primeros años de la enseñanza primaria planificaron y llevaron a cabo una clase considerando aspectos del pensamiento algebraico desde un enfoque pedagógico exploratorio, llevándose en cuenta su participación en la educación continua. El estudio se enmarca en una perspectiva de investigación cualitativo-interpretativa, en la que la recolección de datos provino de la planificación de los docentes, de los registros de audio de las clases, con su posterior transcripción, y registro fotográfico de las tareas matemáticas realizadas por los estudiantes. Los resultados muestran que como consecuencia de la formación realizada, las acciones de planificación y conducción de las clases de los docentes consideraron las fases de la enseñanza exploratoria, así como aspectos del pensamiento algebraico.Palabras clave: Pensamiento algebraico, Practica profesional, Enseñanza exploratoria, Años iniciales, Educación continua
Molecular sieve driven selectivity using encapsulated Pt nanoparticle in single crystal zeolite (2014)

International @ ING+SLI:LGU:YSC:DFA
Receptor activator of nuclear factor-kappa B ligand (RANKL) stimulates bone-associated tumors through functional RANK expressed on bone-associated cancer cells? (2009)

Primary and secondary bone tumors clearly deteriorate quality of life and the activity of daily living of patients. These undesirable diseases become a major social and economic burden. As both primary and secondary bone tumors develop in the unique bone tissue, it is therefore necessary to understand bone cell biology in tumor bone environment. Recent findings of the Receptor Activator of Nuclear Factor-kappaB ligand (RANKL)/RANK/osteoprotegerin (OPG) molecular triad, the key regulators of bone remodeling, opened new era of bone research. Although RANK is an essential receptor for osteoclast formation, activation and survival, functional RANK expression has been recently identified on several bone-associated tumor cells. When RANK is expressed on secondary bone tumor cells, it is implicated in tumor cell migration, whereas this is not the case for primary bone tumors. In any case, RANK is not involved in RANK-positive cell proliferation or death. In two models of bone metastases secondary to melanoma or prostate carcinoma, in vivo neutralization of RANKL by OPG resulted in complete protection from paralysis, due to metastases of vertebral body, and a marked reduction in tumor burden in bones, but not in other organs. OPG also decreased tumor formation and tumor burden in a mouse model of primary bone tumor, osteosarcoma. In all these models, tumor cells express RANK. These data revealed that local differentiation factors, such as RANKL, play an important role in cell migration in a metastatic tissue-specific manner. These findings substantiate the novel direct role of RANKL/RANK in bone-associated tumors, and its capability of representing new therapeutic targets.
Platelet and cell interactions on gold sputter-deposited polymeric surfaces. (1998)

Surface treatment as gold sputter-deposited treatment onto various polymeric surfaces has been investigated to improve the cell-, tissue- and blood-compatibility. Surface treated samples were characterized by measurement of contact angle goniometer and electron spectroscopy for chemical analysis (ESCA). The contact angles on the gold-coated polymeric surfaces decreased from 95-65 degrees to around 50 degrees, i.e., increased hydrophilicity due to incorporation of gold thin layer. From the results of ESCA analysis of the modified polymeric surfaces, surface modification by the gold-sputter method was successfully performed. Morphology of the adhered platelets on the gold-coated polymeric surfaces showed lesser activating than control, and the number of adhered platelets surface modified samples decreased with decreasing water contact angle. Fibroblast cell adhesion and growth on the gold-coated polymeric surfaces were more active than those of control. It seems that surface wettability and surface chemistry of gold play important roles for platelet adhesion and cell adhesion, spreading and growth.
Dendrimers as Scaffolds for Reversible Addition Fragmentation Chain Transfer (RAFT) Agents: a Route to Star-Shaped Block Copolymers (2005)

Star-shaped block copolymers of styrene and n-butyl acrylate having three, six, and twelve pendent arms were successfully synthesized via reversible addition fragmentation chain transfer (RAFT) polymerization. Dendritic cores (based on 1,1,1-trimethylolpropane) of generation 0, 1, and 2 have been functionalized with 3-benzylsulfanylthiocarbonylsulfanylpropionic ester groups and have subsequently been employed to mediate the polymerization of styrene and n-butyl acrylate to generate macro-star-RAFT agents as starting materials for chain extension. The chain extension of the macro-star-RAFT agents with either styrene or n-butyl acrylate by bulk free radical polymerization at 60°C gives narrowly distributed polymer (final polydispersities close to 1.2) increasing linearly in molecular weight with increasing monomer-to-polymer conversion. However, with an increasing number of arms (i.e., when going from three- to twelve-armed star polymers), the chain extension becomes significantly less efficient. The molecular weight of the generated block copolymers was assessed using 1H NMR spectroscopy as well as size exclusion chromatography calibrated with linear polystyrene standards. The hydrodynamic radius, Rh, of the star block copolymers as well as the precursor star polymers was determined in tetrahydrofuran by dynamic light scattering (90°) at 25°C. Interestingly, the observed Rh–Mn relationships indicate a stronger dependence of Rh on Mn for poly(butyl acrylate) stars than for the corresponding styrene polymers. Rh increases significantly when the macro-star-RAFT agent is chain extended with either styrene or n-butyl acrylate.
Hydrothermal Chemistry of the Copper–Triazolate System: A Microporous Metal–Organic Framework Constructed from Magnetic {Cu<sub>3</sub>(μ<sub>3</sub>‐OH)(triazolate)<sub>3</sub>}<sup>2+</sup> Building Blocks, and Related Materials (2006)

Networking with triazolate: Three new compounds containing networks of CuI or CuII ions linked by 1,2,4-triazolate (trz) ligands were prepared by hydrothermal synthesis. The microporous metal–organic framework {Cu3(μ3-OH)(trz)3(OH)2(H2O)4}n, which is built up from magnetic triangles, forms 17×13×13 Å3 cavities (see picture; Cu dark blue, O red, N light blue, C black). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z504128_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Diagonalization of the Finite Hilbert Transform on two adjacent\n intervals (2015)

We study the interior problem of tomography. The starting point is the\nGelfand-Graev formula, which converts the tomographic data into the finite\nHilbert transform (FHT) of an unknown function $f$ along a collection of lines.\nPick one such line, call it the $x$-axis, and assume that the function to be\nreconstructed depends on a one-dimensional argument by restricting $f$ to the\nline. Let $\\Omega_1$ be the interval where $f$ is supported, and $\\Omega_2$ be\nthe interval where the Hilbert transform of $f$ can be computed using the\nGelfand-Graev formula. The equation we study is $H_1 f=g|_{\\Omega_2}$, where\n$H_1$ is the FHT that integrates over $\\Omega_1$ and gives the result on\n$\\Omega_2$, i.e. $H_1: L^2(\\Omega_1)\\to L^2(\\Omega_2)$. In the case of the\ninterior problem the tomographic data are truncated, and $\\Omega_1$ is no\nlonger a subset of $\\Omega_2$. In this paper we consider the case when the\nintervals $\\Omega_1=(a_1,0)$ and $\\Omega_2=(0,a_2)$ are adjacent. Here $a_1 &lt; 0\n&lt; a_2$. First we find a differential operator $L$ that commutes with $H_1$.\nUsing the Titchmarsh-Weyl theory, we show that $L$ has only continuous spectrum\nand obtain two isometric transformations $U_1$, $U_2$, such that $U_2 H_1\nU_1^*$ is the multiplication operator with the function $\\sigma(\\lambda)$,\n$\\lambda\\geq(a_1^2+a_2^2)/8$. Here $\\lambda$ is the spectral parameter. Then we\nshow that $\\sigma(\\lambda)\\to0$ as $\\lambda\\to\\infty$ exponentially fast. We\nalso obtain the leading asymptotic behavior of the kernels involved in the\nintegral operators $U_1$, $U_2$ as $\\lambda\\to\\infty$. When the intervals are\nsymmetric, i.e. $-a_1=a_2$, the operators $U_1$, $U_2$ are obtained explicitly\nin terms of hypergeometric functions.\n
Influence of atomic ordering on the electrocatalytic activity of Pt–Co alloys in alkaline electrolyte and proton exchange membrane fuel cells (2004)

Carbon-supported Pt–Co alloy catalysts with Co contents of 10–50 wt% have been synthesized by reducing aqueous Co2+ ions with borohydride or precipitating as hydroxide in the presence of a commercially available carbon-supported Pt catalyst followed by heat treatment in a 90% Ar–10% H2 mixture at 900 °C for 1 h. X-Ray diffraction indicates the Pt–Co alloys thus obtained to have the ordered Pt3Co or PtCo type structures or the disordered Pt type structure depending on the Co content. High resolution transmission electron microscopy (HRTEM) studies also confirm the formation of ordered structures. Structural analysis of the products after annealing at various temperatures 500 ≤ T ≤ 900 °C for 1 h suggests the ordering to be maximized for an annealing temperature of around 650 °C. Evaluation of the Pt–Co/C alloy catalysts for oxygen reduction in half cells employing KOH as the electrolyte and in proton exchange membrane fuel cells indicates that the alloys with the ordered Pt3Co or PtCo type structures have higher catalytic activity with lower polarization losses and higher power densities than Pt or disordered Pt–Co alloys. With the ordered phases, the activity increases with the extent of ordering. The enhanced catalytic activity is explained based on optimal structural and electronic features consisting of optimum number of Pt and Co nearest neighbors, Pt–Pt distance, and d-electron density in Pt.
Type 1 diabetes risk and autoantibody positivity in Sardinian migrants in the province of Pavia. (2009)

The present study showed a higher prevalence of GADA positivity within Sardinian immigrants at high genetic risk; GADA positivity may represent the first detectable phase of type 1 diabetes. After a seven-year follow-up, none of the high genetic/antibody risk group subjects developed type 1 diabetes. However, it seems reasonable to strictly control high-risk individuals in order to diagnose subclinical diabetes.
ACCORD - Automatic reconfigurable radio for dual-use (2014)

The following paper presents the ACCORD project which is aimed at specifying a complete platform capable of generating innovative terminals able to automatically reconfigure seamless switching between different air interfaces and relevant protocols. The ACCORD solution is a new concept comprising a platform for a family of terminals, which can be easily deployed according to the air interfaces and protocols supported. This truly innovative approach is based on three main features. Firstly a Smart router which provides seamless vertical handover by selecting the most appropriate network based on a Quality of Service policy. Secondly a Hybrid terminal on which both satellite and terrestrial waveforms are present. Lastly a Common Interface which manages the satellite and terrestrial air interfaces and their protocols using a fully Software-Defined Radio approach.
Towards compact coherent and broadband all-normal mid-infrared supercontinuum source (2016)

We present compact and cost-efficient all-normal supercontinuum source. With use of highly nonlinear all-solid photonic crystal fiber, we obtain broadband supercontinuum with pump power requirement decreased by 88% in relation to OPA pumped systems.
Abstract 1408: Activation status and function of the canonical Wnt pathway in murine mammary tumor cells reexpressing Glypican-3 (GPC3) (2012)

Abstract GPC3 is a proteoglycan downregulated in breast cancer cells. We previously demonstrated that GPC3 reexpression inhibits in vivo metastatic potential of LM3 murine mammary adenocarcinoma cells. This event was associated in vitro with a lower motility and an increased aggregation, as well as with an enhanced senescence and apoptosis. We have previous evidence indicating that the canonical Wnt pathway is inhibited in LM3-GPC3 cells. The aim of this work was to validate the inhibition of canonical Wnt signaling in GPC3 reexpressing cells and to investigate whether differences in cell behavior are due to the regulation of GPC3 on this pathway. By means of western blots (WB) we established that LM3-GPC3 cells have 5-10 folds less phosphorylated GSK3B. Using cytoplasmic protein extracts and WB we also determined that GPC3 reexpressing cells present lower levels of cytoplasmic B-Catenin. This was further studied by immunofluorescence (IF), where it was found that while LM3-vector cells show positive signal for B-catenin mainly in nucleus and cytoplasm, this staining is restricted to the membrane and cytoplasm in LM3-GPC3 cells. In addition, a gene reporter assay employing OT/OF plasmids confirmed the canonical Wnt pathway inhibition induced by GPC3. To determine whether cell properties modulated by GPC3 are mediated by the canonical Wnt pathway, we treated cells with its activator LiCl (or NaCl as control). LiCl treatment increases 10-fold the phosphorylation of GSK3B, as compared to LM3-GPC3 cells treated with NaCl, and induces an enhance of about 50% of the canonical Wnt transcriptional activity (gene reporter assay). We confirm that although LiCl partially reverted senescence induced by GPC3 reexpression (Senescent X-Gal positive cells: LM3-GPC3+NaCl= 85% vs. LM3-GPC3+LiCl= 65%, p&amp;lt;0.05), it had no effects on apoptosis. We established by wound healing assays that LM3-GPC3 cells +LiCl recover their ability to migrate (Coverage of the wound: LM3-GPC3+NaCl= 15% vs LM3-GPC3+LiCl= 75%, p&amp;lt;0.05). Finally, LiCl treatment reduced LM3-GPC3 homotypic cell aggregation, reaching similar levels to LM3-vector clones (p&amp;lt;0.05). In summary, we confirm by a new methodological approach that GPC3 inhibits the canonical Wnt signaling. Our results suggest that GPC3 would be modulating senescence, migration and cell aggregation of mammary tumor cells through this pathway inhibition. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 1408. doi:1538-7445.AM2012-1408
State correction after re-routing with reduced state resource reservation protocols (2005)

Recently, a new working group - Next Steps In Signalling (NSIS) - was established within the IETF to develop a general signalling protocol primarily to support QoS resource reservation. Two main operation modes have been clarified: stateful and reduced state. The first mode relies on per flow-state information in all interior nodes while the other uses aggregated states. Stateful operation is based on the resource reservation protocol (RSVP), while reduced state operation will be similar to the resource management in a Diffserv (RMD) framework. With the use of aggregated states instead of per-flow granularity, one looses fine control over resources but derives a scalable and more efficient protocol. However, some problems need new handling mechanisms. In this paper, we discuss the problem of re-routing from the aspect of reduced state resource reservation. We show how quickly and easily RSVP handles such situations but reduced state solutions like RMD require new mechanisms for a quick reaction. We propose and analyse several solutions.