gebhart/patrepeval huggingface dataset:
Low-Temperature-Grown KNbO<sub>3</sub> Thin Films and Their Application to Piezoelectric Nanogenerators and Self-Powered ReRAM Device (2017)

Amorphous KNbO<sub>3</sub> (KN) film containing KN nanocrystals was grown on TiN/SiO<sub>2</sub>/Si substrate at 350 °C. This KN film showed a dielectric constant (ε<sub>r</sub>) and a piezoelectric strain constant (d<sub>33</sub>) of 43 and 80 pm/V at 10 V, respectively, owing to the existence of KN nanocrystals. Piezoelectric nanogenerators (PNGs) were fabricated using KN films grown on the TiN/polyimide/poly(ethylene terephthalate) substrates. The PNG fabricated with the KN film grown at 350 °C showed an open-circuit output voltage of 2.5 V and a short-circuit current of 70 nA. The KN film grown at 350 °C exhibited a bipolar resistive switching behavior with good reliability characteristics that can be explained by the formation and rupture of the oxygen vacancy filaments. The KN resistive random access memory device powered by the KN PNG also showed promising resistive switching behavior. Moreover, the KN film shows good biocompatibility. Therefore, the KN film can be used for self-powered biomedical devices.
Self-Assembly and Novel Functions of pi-Conjugated Metalloporphyrin Dimer (2006)

Abstract not Available.
CT Enteroclysis Features of Uncomplicated Celiac Disease: Retrospective Analysis of 44 Patients (2009)

CT enteroclysis may help establish a diagnosis of uncomplicated CD and may clarify the cause of nonspecific gastrointestinal symptoms in patients with unknown CD. However, future prospective trials are needed to determine the actual value of CT enteroclysis in patients with CD and validate the clinical usefulness of CT enteroclysis in the detection of unknown uncomplicated CD.
OpenMP for networks of SMPs (2003)

In this paper we present the first system that implements OpenMP on a network of shared-memory multiprocessors. This system enables the programmer to rely on a single, standard, shared-memory API for parallelization within a multiprocessor and between multiprocessors. It is implemented via a translator that converts OpenMP directives to appropriate calls to a modified version of the TreadMarks software distributed memory system (SDSM). In contrast to previous SDSM systems for SMPs, the modified TreadMarks uses POSIX threads for parallelism within an SMP node. This approach greatly simplifies the changes required to the SDSM in order to exploit the intra-node hardware shared memory. We present performance results for six applications (SPLASH-2 Barnes-Hut and Water; NAS 3D-FFT, SOR, TSP and MGS) running on an SP2 with four four-processor SMP nodes. A comparison between the threaded implementation and the original implementation of TreadMarks shows that using the hardware shared memory within an SMP node significantly reduces the amount of data and the number of messages transmitted between nodes, and consequently achieves speedups up to 30% better than the original versions. We also compare SDSM against message passing. Overall, the speedups of multithreaded TreadMarks programs are within 7-30% of the MPI versions.
Machine-learning informed prediction of high-entropy solid solution formation: Beyond the Hume-Rothery rules (2020)

Abstract The empirical rules for the prediction of solid solution formation proposed so far in the literature usually have very compromised predictability. Some rules with seemingly good predictability were, however, tested using small data sets. Based on an unprecedented large dataset containing 1252 multicomponent alloys, machine-learning methods showed that the formation of solid solutions can be very accurately predicted (93%). The machine-learning results help identify the most important features, such as molar volume, bulk modulus, and melting temperature. As such a new thermodynamics-based rule was developed to predict solid–solution alloys. The new rule is nonetheless slightly less accurate (73%) but has roots in the physical nature of the problem. The new rule is employed to predict solid solutions existing in the three blocks, each of which consists of 9 elements. The predictions encompass face-centered cubic (FCC), body-centered cubic (BCC), and hexagonal closest packed (HCP) structures in a high throughput manner. The validity of the prediction is further confirmed by CALculations of PHAse Diagram (CALPHAD) calculations with high consistency (94%). Since the new thermodynamics-based rule employs only elemental properties, applicability in screening for solid solution high-entropy alloys is straightforward and efficient.
Cardiomyocyte S1P1 Receptor-mediated Extracellular Signal-related Kinase Signaling and Desensitization (2009)

We examined the ability of sphingosine-1-phosphate (S1P) to desensitize extracellular signal-related kinase (ERK), a mitogen-activated protein kinase linked to antiapoptotic responses in the heart. In isolated adult mouse cardiomyocytes, S1P (10 nM-5 microM) induced ERK phosphorylation in a time- and dose-dependent manner. S1P stimulation of ERK was completely inhibited by an S1P1/3 subtype receptor antagonist (VPC23019), by a Gi protein inhibitor (pertussis toxin) and by a mitogen-activated protein kinase/ERK kinase inhibitor (PD98059). A selective S1P3 receptor antagonist (CAY10444) had no effect on S1P-induced ERK activation. The selective S1P1 agonist SEW2871 also induced ERK phosphorylation. Activation of ERK by restimulation with 100 nM S1P was suppressed after 1 hour of preincubation with 100 nM S1P but recovered fully the next day, suggesting receptor recycling. Similar results were obtained in protein kinase C epsilon-null cardiomyocytes. Treatment with the nonselective S1P receptor agonist FTY720 for 1 hour also reduced phospho-ERK expression in response to subsequent S1P stimulation. In contrast to S1P, some desensitization to FTY720 persisted after overnight exposure. Cell death induced by hypoxia/reoxygenation was reduced by pretreatment with exogenous S1P. This enhanced survival was abrogated by pretreatment with PD98059, VPC23019, or pertussis toxin. Thus, exogenous S1P induces rapid and reversible S1P1-mediated ERK phosphorylation. S1P-induced adult mouse cardiomyocyte survival requires ERK activation mediated via an S1P1-Gi pathway.
A New Modular Indole Synthesis. Construction of the Highly Strained CDEF Parent Tetracycle of Nodulisporic Acids A and B (2006)

[reaction: see text] Construction of the highly strained CDEF parent tetracycle, a structural motif found only in the potent ectoparasiticidal agents (+)-nodulisporic acids A and B and related congeners, has been achieved via a new modular indole synthesis, exploiting a sequential Stille cross-coupling/Buchwald-Hartwig union/cyclization tactic. The new indole synthesis holds the promise of rapid assembly of diverse, highly substituted indoles possessing uncommon substitution patterns.
Therapeutic Efficacy of a VSV-GP-based Human Papilloma Virus Vaccine in a Murine Cancer Model (2023)

Human papilloma virus (HPV) infections are associated with almost all cervical cancers and to a lower extend also with anogenital or oropharyngeal cancers. HPV proteins expressed in HPV-associated tumors are attractive antigens for cancer vaccination strategies as self-tolerance, which is associated with most endogenous tumor-associated antigens, does not need to be overcome. In this study, we generated a live attenuated cancer vaccine based on the chimeric vesicular stomatitis virus VSV-GP, which has previously proven to be a potent vaccine vector and oncolytic virus. Genes at an earlier position in the genome more to the 3' end are expressed stronger compared to genes located further downstream. By inserting an HPV16-derived antigen cassette consisting of E2, E6 and E7 into VSV-GP either at first (HPVp1) or fifth (HPVp5) position in VSV-GP's genome we aimed to analyze the effect of vaccine antigen position and consequently expression level on viral fitness, immunogenicity, and anti-tumoral efficacy in a syngeneic mouse tumor model. HPVp1 expressed higher amounts of HPV antigens compared to HPVp5 in vitro but had a slightly delayed replication kinetic which overall translated into increased HPV-specific T cell responses upon vaccination of mice. Immunization with both vectors protected mice in prophylactic and in therapeutic TC-1 tumor models with HPVp1 being more effective in the prophylactic setting. Taken together, VSV-GP is a promising candidate as therapeutic HPV vaccine and first position of the vaccine antigen in a VSV-derived vector seems to be superior to fifth position.
Adaptation in TCP/AQM Networks (2003)

Congestion control in TCP/AQM networks is ex- pected to perform well for a wide-range of conditions, but recent advances in modeling and analysis indicate that present AQM schemes need an extra dose of adaptability to cope. This paper answers the call and proposes a self-tuning structure wherein AQM parameters are automatically tuned in response to on-line estimation of link capacity and traffic load. This approach is applicable to any AQM scheme that is parameterizable in terms of link capacity and TCP load. In this paper, we will describe this self-tuning structure, illustrate its application to PI and RED AQMs, provide stability analysis, and conduct ns simulations to compare with both fixed AQM schemes and the recently proposed adaptive RED.
Active Molecular Plasmonics: Controlling Plasmon Resonances with Molecular Switches (2009)

A gold nanodisk array, coated with bistable, redox-controllable [2]rotaxane molecules, when exposed to chemical oxidants and reductants, undergoes switching of its plasmonic properties reversibly. By contrast, (i) bare gold nanodisks and (ii) disks coated with a redox-active, but mechanically inert, control compound do not display surface-plasmon-based switching. Along with calculations based on time-dependent density functional theory, these experimental observations suggest that the nanoscale movements within surface-bound "molecular machines" can be used as the active components in plasmonic devices.
Glial-modulating agents for the treatment of pain: protocol for a systematic review (2022)

CRD42021262074.
Margin-Based Framework for Online Contingency Selection in Unbalanced Networks (2016)

A framework for performing fast online contingency selection in unbalanced power systems is presented in this paper. Selection methods are typically based on the principle of identifying the effect of contingencies on multiple normalized performance indices and ranking them using the results. Presently used performance indices are highly nonlinear and they are known to mask the effects of single contingencies leading to misclassifications. In this paper, we propose two new methods, one relying on margin-based performance indices and another based on state sensitivity. New performance indices are proposed based on margins of 1) circuit loading, 2) bus voltages, and 3) reactive power. In addition, a state sensitivity method is proposed which estimates a system's post contingency operating state via a single iteration of the quadratized power flow model and provides estimates of post contingency line loading, bus voltages, and reactive power levels. Numerical experiments on a three phase version of the IEEE Reliability Test System show that the proposed performance indices yield more accurate results, at a computational cost comparable to a single power flow iteration. The state sensitivity method is more accurate in identifying critical contingencies but its computational cost is higher. The method has been also demonstrated in the larger PEGASE systems.
Targeting Metal Impurities for the Detection and Quantification of Carbon Black Particles in Water via spICP-MS (2022)

Carbon black (CB) is a nanomaterial with numerous industrial applications and high potential for integration into nano-enabled water treatment devices. However, few analytical techniques are capable of measuring CB in water at environmentally relevant concentrations. Therefore, we intended to establish a quantification method for CB with lower detection limits through utilization of trace metal impurities as analytical tracers. Various metal impurities were investigated in six commercial CB materials, and the Monarch 1000 CB was chosen as a model for further testing. The La impurity was chosen as a tracer for spICP-MS analysis based on measured concentration, low detection limits, and lack of polyatomic interferences. CB stability in water and adhesion to the spICP-MS introduction system presented a challenge that was mitigated by the addition of a nonionic surfactant to the matrix. Following optimization, the limit of detection (64 μg/L) and quantification (122 μg/L) for Monarch 1000 CB demonstrated the applicability of this approach to samples expected to contain trace amounts of CB. When compared against gravimetric analysis and UV–visible absorption spectroscopy, spICP-MS quantification exhibited similar sensitivity but with the ability to detect concentrations an order of magnitude lower. Method detection and sensitivity was unaffected when dissolved La was spiked into CB samples at environmentally relevant concentrations. Additionally, a more complex synthetic matrix representative of drinking water caused no appreciable impact to CB quantification. In comparison to existing quantification techniques, this method has achieved competitive sensitivity, a wide working range for quantification, and high selectivity for tracing possible release of CB materials with known metal contents.
Immunocytochemical analysis of cholinergic amacrine cells in the tiger salamander retina (2001)

Cholinergic amacrine cells in the tiger salamander retina were observed for the first time by using antibodies against choline acetyltransferase (ChAT). ChAT-immunoreactive cells were present in the inner nuclear layer (INL) and in the ganglion cell layer (GCL), and the somas of the former population (average diameter = 15.13 microm) were slightly smaller than those of the latter population (average diameter = 16.42 microm). The processes of these cells form two distinct narrow bands in the inner plexiform layer (IPL), one located near 0.2 inner plexiform units (IU) and the other near 0.65-0.7 IU. Soma size, cell density and spatial distribution of ChAT-positive cells were quantitatively analyzed. Our results suggest that cholinergic amacrine cells in the salamander retina are very similar to their counter parts in other species, and they can be used as a model system for studying cholinergic functions in the visual system.
New Stereoacuity Test Using a 3-Dimensional Display System in Children (2015)

The previously developed 3-dimensional (3D) display stereoacuity tests were validated only at distance. We developed a new stereoacuity test using a 3D display that works both at near and distance and evaluated its validity in children with and without strabismus. Sixty children (age range, 6 to 18 years) with variable ranges of stereoacuity were included. Side-by-side randot images of 4 different simple objects (star, circle, rectangle, and triangle) with a wide range of crossed horizontal disparities (3000 to 20 arcsec) were randomly displayed on a 3D monitor with MATLAB (Matworks, Inc., Natick, MA, USA) and were presented to subjects wearing shutter glasses at 0.5 m and 3 m. The 3D image was located in front of (conventional) or behind (proposed) the background image on the 3D monitor. The results with the new 3D stereotest (conventional and proposed) were compared with those of the near and distance Randot stereotests. At near, the Bland-Altman plots of the conventional and proposed 3D stereotest did not show significant difference, both of which were poorer than the Randot test. At distance, the results of the proposed 3D stereotest were similar to the Randot test, but the conventional 3D stereotest results were better than those of the other two tests. The results of the proposed 3D stereotest and Randot stereotest were identical in 83.3% at near and 88.3% at distance. More than 95% of subjects showed concordance within 2 grades between the 2 tests at both near and distance. In conclusion, the newly proposed 3D stereotest shows good concordance with the Randot stereotests in children with and without strabismus.
Adaptive polymer lens for rapid zoom shortwave infrared imaging applications (2014)

This work demonstrates the use of adaptive polymer lenses (APLs) for short-wavelength infrared (SWIR) applications. First, we present a push-button adaptive optical zoom system for variable magnification with a SWIR focal plane array. We then present a push-button, variable divergence, SWIR laser system for pointing and illumination. Last, we outline a system that combines the two: an SWIR adaptive zoom coupled with an APL-enhanced designator/illuminator. The result would allow a user to toggle between different fields of view (magnification), while optimizing illumination (beam divergence) for each field of view. This could be critical for situational awareness and target identification/designation in tactical applications.
Abstract 1568: PLK activated TGF-β functions as a prognostic biomarker for patients with pancreatic ductal adenocarcinoma (2022)

Abstract Introduction: Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer death with a 5-year survival rate of approximately 7%. Transforming growth factor beta (TGF-β) is highly involved in progression and metastasis in multiple cancers including PDAC. TGF-β is highly involved in tumor fibrosis and immune suppression, and several clinical trials are ongoing to evaluate anti-TGF-β therapies for treating patients diagnosed with cancer and for which biomarkers are key for success. TGF-β is produced in a latent complex with latency-associated protein (LAP), which needs to be cleaved by plasma kallikrein (PLK), releasing TGF-β to enable receptor binding and initiating of signaling. We developed a competitive enzyme-linked immunosorbent assay (ELISA) targeting PLK activated TGF-β and measured it in serum from patients with PDAC. Methods: An ELISA based on monoclonal antibodies raised against the C-terminal side of the PLK cleavage site of TGF-β at R’58↓ was developed and validated for quantification of PLK activated TGF-β (L59TGF-β) in serum. To confirm that the ELISA was specifically measuring PLK cleaved TGF-β, L59TGF-β was measured in a TGF-β dilution after incubation with and without kallikrein. L59TGF-β was measured in pretreatment serum samples from patients with PDAC (n=39) and healthy controls (n=20). The prognostic value of L59TGF-β levels was examined with Kaplan-Meier analysis and evaluated for association with overall survival (OS) by multivariate cox regression analysis adjusted for age and cancer stage. Results: L59TGF-β was only detected after incubation with kallikrein, demonstrating that the ELISA specifically detected kallikrein cleaved TGF-β. L59TGF-β was significantly elevated in patients with PDAC compared to healthy controls (p&amp;lt;0.0001). High levels of L59TGF-β (&amp;gt;median) were significantly associated with poor OS (HR: 2.71, 95%CI: 1.23-5.97, p=0.0135) in patients with PDAC, and median OS was 5.5 months (95%CI: 1.50-20.0) compared to 26.3 months (95%CI: 15.3-28.1) for patients with low levels of L59TGF-β. The association between high levels of L59TGF-β and poor OS remained statistically significant after adjusting for age and stage (HR: 2.33, 95%CI: 1.05-5.18, p=0.0372). Conclusion: Quantification of PLK activated TGF-β (L59TGF-β) in serum predicted poor OS for patients with PDAC. The biomarker value of L59TGF-β should be validated and further investigated in a larger cohort to explore the clinical applicability of the biomarker. Citation Format: Rasmus S. Pedersen, Neel I. Nissen, Christina Jensen, Jeppe Thorlacius-Ussing, Majken L. Olesen, Lasse Langholm, Tina M. Jensen, Hadi M. Diab, Lars N. Jørgensen, Morten Karsdal, Nicholas Willumsen. PLK activated TGF-β functions as a prognostic biomarker for patients with pancreatic ductal adenocarcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1568.
Gel-Like Calcium Carbonate Precursors Observed by <i>in situ</i> AFM (2016)

The debate about crystallization processes is still ongoing and nonclassical crystallization mechanisms attract more and more attention. This work indicates that polymer induced liquid precursor (PILP) phases play a role for nonclassical calcium carbonate crystallization and growth processes. Here we report the observation of gel-like precursors for the crystal growth on a calcite surface by means of an in situ AFM study. These precursors spread out on the surface with time supporting their liquid character. This study will give new insights into biomineralization and crystallization processes in general.
The +276 G/T Single Nucleotide Polymorphism of the Adiponectin Gene Is Associated With Coronary Artery Disease in Type 2 Diabetic Patients (2004)

In conclusion, the +276 G>T polymorphism is a determinant of CAD risk in type 2 diabetic patients. This marker may assist in the identification of diabetic individuals at especially high risk of CAD, so that preventive programs can be targeted at these subjects.
Progress in organic electroluminescent devices with air stable cathodes (1999)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. E. Jabbour, "Progress in organic electroluminescent devices with air stable cathodes," in Organic Thin Films for Photonic Applications, OSA Technical Digest (Optica Publishing Group, 1999), paper FD4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Helium isotope characteristics of Andean Convergent Margin geothermal fluids (2022)

Earth and Space Science Open Archive Presented WorkOpen AccessYou are viewing the latest version by default [v1]Helium isotope characteristics of Andean Convergent Margin geothermal fluidsAuthorsPeterBarryiDDavidBekaertAlanSeltzerJoshuaCurticeMaartende MoorGerdhardJessenDonatoGiovannelliiDMattSchrenkJoyBuongiornoiDAgostinaChiodiiDCarlosRamirezTimothyRogersKarenLloydSee all authors Peter BarryiDCorresponding Author• Submitting AuthorWoods Hole Oceanographic InstitutioniDhttps://orcid.org/0000-0002-6960-1555view email addressThe email was not providedcopy email addressDavid BekaertWoods Hole Oceanographic Institutionview email addressThe email was not providedcopy email addressAlan SeltzerWoods Hole Oceanographic Institutionview email addressThe email was not providedcopy email addressJoshua CurticeWoods Hole Oceanographic Institutionview email addressThe email was not providedcopy email addressMaarten de MoorObservatorio Vulcanológico y Sismológico de Costa Ricaview email addressThe email was not providedcopy email addressGerdhard JessenUniversidad Austral de Chile, Los Ríos, Chileview email addressThe email was not providedcopy email addressDonato GiovannelliiDUniversity of Naples "Federico II"iDhttps://orcid.org/0000-0001-7182-8233view email addressThe email was not providedcopy email addressMatt SchrenkMichigan State Universityview email addressThe email was not providedcopy email addressJoy BuongiornoiDMaryville CollegeiDhttps://orcid.org/0000-0002-7442-0599view email addressThe email was not providedcopy email addressAgostina ChiodiiDInstituto de Bio Y Geociencias Del Noroeste Argentino, Salta, ArgentinaiDhttps://orcid.org/0000-0002-5257-2858view email addressThe email was not providedcopy email addressCarlos RamirezServicio Geológico Ambiental (SeGeoAm) Heredia, Costa Ricaview email addressThe email was not providedcopy email addressTimothy RogersUniversity of Tennesseeview email addressThe email was not providedcopy email addressKaren LloydUniversity of Tennesseeview email addressThe email was not providedcopy email address