gebhart/patrepeval huggingface dataset:
Investigation on Improving Color Crosstalk for High-Transmittance TFT-LCDs (2022)

The effect of inter-electrode coupling on color crosstalk (CCT) of TFT-LCD with high transmittance pixel design is investigated systematically. Theoretical analysis shown that the increased asymmetric capacitive coupling effect between data and pixel electrode signals is the main reason for CCT of the high transmittance panels. If applying some traditional strategies to improve CCT under the line-inversion driving scheme, the effectiveness is very limited and there is a loss of transmittance. When using the proposed sup-flip driving scheme, good image quality with weak CCT can be obtained in the color images. This is mainly ascribed to the dot inversion driving mode of pixel signals, which greatly weakens the coupling effect caused by the change of data signals and balances the brightness difference between adjacent pixels. These results demonstrate that applying the proposed super flip driving scheme is an effective way to modulate the CCT defect and enhance the display performance for TFT-LCDs with high transmittance design.
Photoinduced diffusion of Ag in Ge<i>x</i>Se1−<i>x</i> glass (1985)

Diffusion of Ag in GexSe1−x (x∼0.1) under UV light irradiation is studied using Rutherford backscattering spectrometry and microlithography techniques. The diffusion coefficient at 21 °C and 2 mW/cm2 is determined to be 2.7 nm2/s. The temperature dependence of the diffusivity follows an Arrhenius-type equation with an activation energy of 5.32 kcal/mole (0.23 eV) and a pre-exponent factor of 2.5×104 nm2/s. The reciprocity of irradiation intensity and exposure time with respect to the diffusion distance is confirmed. Specifically, the diffusivity is found to be directly proportional to the irradiation intensity.
Antibodies to SARS-CoV-2 and risk of future sickness (2020)

Abstract Background The extent that antibodies to SARS-CoV-2 may protect against future virus-associated disease is unknown. Method We analyzed 12928 healthy hospital employees for SARS-CoV-2 antibodies and compared results to participant sick leave records (Clinical trial registration: https:ClinicalTrials.gov NCT04411576 ). Results Subjects with viral serum antibodies were not at excess risk for future sick leave (Odds Ratio (OR): 0.85 (95% Confidence Interval (CI) (0.85 (0.43-1.68)). By contrast, subjects with antibodies had an excess risk for sick leave in the past weeks (OR: 3.34 (2.98-3.74)). Conclusion Presence of viral antibodies marks past disease and protection against excess risk of future disease.
ST-Elevation Myocardial Infarction Networks and Logistics: Rural and Urban (2018)

The facilities and expertise required for primary percutaneous coronary intervention (PPCI) of the infarct-related artery (IRA) in patients with ST-elevation myocardial infarction (STEMI) are only available at a limited number of hospitals. Fibrinolytic therapy, on the other hand, is more widely deliverable. This creates two distinct reperfusion choices: PPCI or a pharmacoinvasive strategy. The first option relies on immediate transfer to the closest PPCI-capable centre even if it means bypassing a closer non-PPCI centre. The second option is the “drip and ship” strategy. It involves delivery of fibrinolytic therapy by a non-PPCI facility with rapid transfer to a PPCI-capable centre.
Proteomics Data Collection – 3<sup>rd</sup> ProDaC Workshop April 22<sup>nd</sup> 2008, Toledo, Spain (2008)

The "Coordination Action" ProDaC (Proteomics Data Collection) - funded by the EU within the 6th framework programme - was created to support the dissemination, utilization and publication of proteomics data. Within this international consortium, standards are developed and maintained to support extensive data collection by the proteomics community. An important part of ProDaC are workshops organized on a regular basis (two per year) to allow discussions and communication between the ProDaC partners and to report on the progress of the project. The kick-off meeting took place in October 2006 in Long Beach, CA, USA. The 1st ProDaC workshop was held in Lyon, France (April 2007) and the 2nd in Seoul, Korea in October 2007. ProDaC organized the 3rd ProDaC workshop at the Beatriz Hotel, Toledo, on 22nd April, 2008, directly before the HUPO - PSI spring meeting (Human Proteome Organisation - Proteomics Standards Initiative). The work package coordinators presented talks about the progress achieved during the past six months. Additionally four external speakers presented their work on data conversion and data repositories. The concluding discussion session was chaired by the Journal's representative.
Predictive Role of Temporal Changes in Intratumoral Metabolic Heterogeneity During Palliative Chemotherapy in Patients with Advanced Pancreatic Cancer: A Prospective Cohort Study (2019)

Metabolic intratumoral heterogeneity (ITH) is known to be related to cancer treatment outcome. However, information on the temporal changes in metabolic ITH during chemotherapy and the correlations between metabolic changes and treatment outcomes in patients with pancreatic cancer is sparse. We aimed to analyze the temporal changes in metabolic ITH and the predictive role of its changes in advanced pancreatic cancer patients who underwent palliative chemotherapy. <b>Methods:</b> We prospectively enrolled patients with unresectable locally advanced or metastatic pancreatic cancer before first-line palliative chemotherapy. <sup>18</sup>F-FDG PET was performed at baseline and at the first response follow-up. SUVs, volumetric parameters, and textural features of the primary pancreatic tumor were analyzed. Relationships between the parameters at baseline and first follow-up were assessed, as well as changes in the parameters with treatment response, progression-free survival (PFS), and overall survival (OS). <b>Results:</b> Among 63 enrolled patients, the best objective response rate was 25.8% (95% confidence interval [CI], 14.6%-37.0%). The median PFS and OS were 7.1 mo (95% CI, 5.1-9.7 mo) and 10.1 mo (95% CI, 8.6-12.7 mo), respectively. Most parameters changed significantly during the first-line chemotherapy, in a way of reducing ITH. Metabolic ITH was more profoundly reduced in responders than in nonresponders. Multiple Cox regression analysis identified high baseline compacity (<i>P</i> = 0.023) and smaller decreases in SUV<sub>peak</sub> (<i>P</i> = 0.007) and entropy gray-level cooccurrence matrix (<i>P</i> = 0.033) to be independently associated with poor PFS. Patients with a high carbohydrate antigen 19-9 (<i>P</i> = 0.042), high pretreatment SUV<sub>peak</sub> (<i>P</i> = 0.008), and high coefficient of variance at first follow-up (<i>P</i> = 0.04) showed worse OS. <b>Conclusion:</b> Reduction in metabolic ITH during palliative chemotherapy in advanced pancreatic cancer patients is associated with treatment response and might be predictive of PFS and OS.
Curcumin prevents muscle damage by regulating NF-kB and Nrf2 pathways and improves performance: an in vivo model (2016)

This study suggests that novel CW has the potential to help prevent muscle damage by regulating the nuclear factor-κB and nuclear factor (erythroid-derived 2)-like 2 pathways and improve the performance and nutritional values of CW.
Aspirin is Clinically Effective in Chemoprevention of Colorectal Neoplasia: Point (2008)

Colorectal cancer (CRC) prevention has become an important goal for health providers, physicians, and the general public. CRC is a highly prevalent disease that is associated with considerable mortality and morbidity rates, with >1,000,000 new cases and 500,000 deaths expected worldwide in 2006 ([1
Adaptation of proteins from hyperthermophiles to high pressure and high temperature. (1999)

Further clarification of the adaptations permitting the persistence of life at temperatures above 100 degrees C depends in part on the analysis of adaptive mechanisms at the protein level. The hyperthermophiles include both Bacteria and Archaea, although the majority of isolates growing at or above 100 degrees C are Archaea. Newly described adaptive features of hyperthermophiles include proteins whose structural integrity persists at temperatures up to 200 degrees C, and under elevated hydrostatic pressure, which in some cases adds significant increments of stability.
Cerebellar growth in normal fetuses of multiple gestations (2002)

There was no significant difference observed in cerebellar growth among singleton and multiple gestations. Therefore, nomograms previously established for singleton pregnancies may be useful to assess growth in multifetal pregnancies.
Excess Quantum Noise due to Nonorthogonal Polarization Modes (1997)

We show that the quantum-limited linewidth of a laser can be enhanced when the polarization eigenmodes of the laser resonator are nonorthogonal. For the theoretical description of this phenomenon we introduce a simple coupled two-mode model. Experimentally, we observed an enhancement of the quantum noise by a factor of 60 in a He-Xe gas laser.
ENGINEERING A NEW MATERIAL FOR HOT GAS CLEANUP (2001)

The overall objective of this project is the engineering development of a reusable calcium-based sorbent for desulfurizing hot coal gas. A two-step pelletization method has been employed to produce relatively strong, ''core-in-shell,'' spherical pellets. Each pellet consists of a highly reactive core surrounded by a strong, inert, porous shell. A suitable core is composed largely of CaO which reacts with H{sub 2}S to form CaS. Pellet cores have been prepared by pelletizing either pulverized limestone or plaster of Paris, and shells have been made of various materials. The most suitable shell material has been formed from a mixture of alumina and limestone particles. The core-in-shell pellets require treatment at high temperature to convert the core material to CaO and to partially sinter the shell material. Pellet cores derived from plaster of Paris have proved superior to those derived from limestone because they react more rapidly with H{sub 2}S and their reactivity does not seem to decline with repeated loading and regeneration. The rate of reaction of H{sub 2}S with CaO derived from either material is directly proportional to H{sub 2}S concentration. The rate of reaction does not appear to be affected significantly by temperature in the range of 1113 K (840 C) to 1193 K (920 C) but decreases markedly at 1233 K (960 C). The rate is not affected by shell thickness within the range tested, which also provides adequate compressive strength.
Osteoporosis in Children With Severe Congenital Neutropenia: Bone Mineral Density and Treatment With Bisphosphonates (2006)

A high incidence of decreased bone mineral density (BMD) has been described in patients with severe congenital neutropenia (SCN). The objectives of the study are to describe changes in BMD in children with SCN treated with granulocyte colony-stimulating factor and evaluate the response to treatment with bisphosphonates in those who had osteoporosis. A prospective open-label study was performed evaluating BMD and metabolism in 9 Chilean patients with SCN, administrating bisphosphonates in those with osteoporosis. Follow-up ranged between 7 months and 3.5 years. Six out of 9 patients had reduced BMD on initial assessment: 3 had osteoporosis (z score <-2) and 3 had osteopenia (z score <-1). Four children presented vertebral fractures. Two presented osteopenia on follow-up without clinical symptoms. Five patients were treated with bisphosphonates, increasing their BMD z score (mean increase 1.2, range 0.27 to 2.62). z Score of hydroxyproline/creatinine ratios, which was elevated in 4 patients with osteoporosis, decreased during treatment (mean decrease 2.18, range 1.56 to 2.53). Four patients remodeled and reexpanded fractured vertebrae during treatment. No side effects of bisphosphonates were seen on follow-up. Osteoporosis is an important comorbidity in SCN patients probably due to increased bone resorption. Bisphosphonates seem to be an effective treatment for osteoporosis in these patients.
141: Macrophage Migration Inhibitory Factor Mediates Smooth Muscle Death in Bladder Outlet Obstruction (2005)

You have accessJournal of UrologyDiscussed Poster, Sunday, May 22, 2005, 8:00 am - 12:00 pm1 Apr 2005141: Macrophage Migration Inhibitory Factor Mediates Smooth Muscle Death in Bladder Outlet Obstruction John A. Taylor, Qing Zhu, Dan Sasso, Carol Pilbeam, Lin Leng, Richard Bucala, and George A. Kuchel John A. TaylorJohn A. Taylor More articles by this author , Qing ZhuQing Zhu More articles by this author , Dan SassoDan Sasso More articles by this author , Carol PilbeamCarol Pilbeam More articles by this author , Lin LengLin Leng More articles by this author , Richard BucalaRichard Bucala More articles by this author , and George A. KuchelGeorge A. Kuchel More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)34406-9AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "141: Macrophage Migration Inhibitory Factor Mediates Smooth Muscle Death in Bladder Outlet Obstruction." The Journal of Urology, 173(4S), p. 38 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 173Issue 4SApril 2005Page: 38 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information John A. Taylor More articles by this author Qing Zhu More articles by this author Dan Sasso More articles by this author Carol Pilbeam More articles by this author Lin Leng More articles by this author Richard Bucala More articles by this author George A. Kuchel More articles by this author Expand All Advertisement PDF DownloadLoading ...
Attention Deficit Hyperactivity Disorder in Pediatric Patients with Pheochromocytoma and Paraganglioma (2016)

The aim of the study is to evaluate if there is an association between attention deficit hyperactivity disorder (ADHD) and the diagnosis of pheochromocytoma/paraganglioma (PHEO/PGL) in pediatric patients. A case series study of 43 patients under the age of 18 with PHEO/PGL tumors who were evaluated at the National Institute of Health between January 2006 and May 2014 is reported. Prior diagnosis of ADHD and treatment course with stimulant medications was recorded. Patient symptoms, catecholamine and metanephrine levels, tumor characteristics, and genetic analyses for syndromes associated with PHEO/PGL were evaluated. A chi-squared test was used to assess the prevalence of ADHD in the PHEO/PGL patients compared to the general population. Nine out of 43 (21%) of patients diagnosed with PHEO/PGL had been diagnosed with ADHD prior to tumor identification. Four of the 9 patients had been treated with amphetamine, dextroamphetamine, and/or methylphenidate, potentially exacerbating an adrenergic crisis. In addition, 4 patients exhibited hypertension at the initial diagnosis of their PHEO/PGL. Three patients had resolution of their ADHD symptoms after successful surgical removal of PHEO/PGL. Our study found a prevalence of ADHD in 21% of our PHEO/PGL patients, significantly higher than 7.2% seen in the general pediatric population. Symptoms of anxiety and difficulty in concentration in these patients may have been related to their underlying PHEO/PGL and were not recognized as part of the constellation of symptoms in a child with PHEO/PGL. In pediatric patients with hypertension and ADHD symptomatology, an evaluation to rule out PHEO/PGL is warranted prior to treatment with stimulant medications.
Intrinsic Catalytic Cracking Activity of Hexane over H−ZSM-5, H−β and H−Y Zeolites (1999)

Mono- and bimolecular intrinsic rate constants for the conversion of n-hexane over H−Y, H−ZSM-5, and H−β zeolites were measured at 623 K by combining conventional catalytic techniques with gravimetric adsorption measurements. Since H-zeolites are catalytically active, their adsorption properties under reaction conditions could not be directly obtained. Rather, adsorption experiments were carried out on the H-zeolites at temperatures below the onset of catalytic activity (450−530 K). Thermodynamic adsorption constants for the H forms at 623 K were then obtained by extrapolation. In addition, the catalytically inactive Na forms were chosen to characterize the overall temperature dependence of n-hexane adsorption on ZSM-5, Y, and β zeolites in the range 450−623 K. For the cracking experiments, monomolecular conditions were ensured by choosing a low hexane pressure (<0.57 kPa) and short contact times. The intrinsic activity for mono- and bimolecular n-hexane cracking over the zeolites, after taking into account the amounts of adsorbed hydrocarbon, was in the order H−ZSM-5 > H−β > dealuminated H−Y ≫ H−Y.
Evanescent-Wave Fiber-Optic Sensor: On Power Transfer From Core-Cladding Interface to Fiber End-Face (2011)

In this paper, the enhancement of collection efficiency in fiber-optic evanescent-wave (EW) sensors is studied. Both theory and experimental results are presented. The key is to consider the roughness conditions at the end-face of large-core fibers. The theory is based primarily on ray optics, but for the sake of simplicity and accuracy, wave optics is also considered. Fluorescent light is coupled into the core of a partly unclad multimode fiber. Most power is carried to the unclad end-face by tunneling modes. Reflection from this rough end-face, which is modeled as a diffuse source, mixes the initial modes. Bound rays also play an important role, carrying the power to the other end-face. The amount of output power of the bound rays there is calculated. We also study the output power in relation to the surface condition of the far end-face, which may be smooth or rough. The comparison of these cases in terms of output power shows that a rough near end-face enhances the collection of coupled fluorescent light. In contrast, roughening of the far end-face while the near end-face is rough causes a transfer of the initial, mostly tunneling, modes to the radiation modes and decreases the collectable signal.
Implementation and performance issues in collaborative optimization (1996)

Collaborative optimization is a multidisciplinary design architecture that is well-suited to large-scale multidisciplinary optimization problems. This paper compares this approach with other architectures, examines the details of the formulation, and some aspects of its performance. A particular version of the architecture is proposed to better accommodate the occurrence of multiple feasible regions. The use of system level inequality constraints is shown to increase the convergence rate. A series of simple test problems, demonstrated to challenge related optimization architectures, is successfully solved with collaborative optimization.
Abstract 3617: Investigating a role for PIKfyve in cell migration and invasion of clear cell renal cell carcinoma (2023)

Abstract Introduction. Clear cell renal cell carcinoma (ccRCC) is the most frequent type of kidney cancer. These highly vascularized tumors are characterized by mutations that inactivate the von Hippel-Lindau (VHL) tumor suppressor gene. About 30 % of patients present metastasis at diagnosis and 30-40% of patients with localized tumors relapse after surgery. Unfortunately, metastatic ccRCC remains incurable and are resistant to standard therapies. Our studies demonstrated that ccRCC with a loss of VHL can be targeted using a small molecule named STF-62247. This molecule blocks the autophagic flux causing enlargement of endolysosomes leading to cell death. More recently, we identified the lipid kinase PIKfyve as a target of STF-62247. A central complex assuring the functionality of the lysosome is formed by the lipid kinase PIKfyve, the scaffold protein ArPIKfyve (Vac14), and the phosphatase Sac3 (Fig4). Interestingly, PIKfyve has shown to play a role in cell migration but the mechanisms are not well understood. Objectives. Our project aims to i) assess a role for PIKfyve in ccRCC migration/invasion, ii) evaluate the potential of PIKfyve inhibitors on angiogenesis, and iii) assess the effect of PIKfyve inhibitors or genetic knockdown of PIKfyve, Vac14 or Fig4 on tumor growth in vivo. Methods and Results. PIKfyve, Vac14 and Fig4 gene expression were modified using CRISPR/Cas9 (Cr) or the SMARTvectorTM Inducible Lentiviral shRNA system. qRT-PCR and western blot validated our models. Results obtained in Cr.PIKfyve and Cr.Vac14 indicated that loss of Vac14 decreased survival of VHL-deficient ccRCC. Moreover, our recent results show that migration measured by wound healing assay is reduced in CRISPR cells compared to control. To investigate a role for PIKfyve in angiogenesis, tube formation assay was performed in treated cells with PIKfyve inhibitors. Our results indicated a reduction in tube formation in STF-62247 and apilimod treated cells. Furthermore, we will use the proteome profiler human angiogenesis array to identify angiogenic proteins linked to PIKfyve activity. Conclusion. Understanding how PIKfyve is involved in the process of angiogenesis would play a major role in the knowledge for new targeted therapies inkidney cancer. Citation Format: Jolène Cormier, Sandra Turcotte. Investigating a role for PIKfyve in cell migration and invasion of clear cell renal cell carcinoma. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3617.
Antiferromagnetically coupled capped bit patterned media for high-density magnetic recording (2011)

We report micromagnetic modeling of a bit patterned media where a two-dimensional array of patterned composite islands is antiferromagnetically coupled to a continuous capping layer. This media allows optimization of writability, switching field distributions, and readback response. Lateral and vertical exchange introduced through the coupling with the capping layer compensates the dipolar interactions between islands and antiferromagnetic coupling is employed to modulate the high-density readback response.
Waveguide Integrated MoTe2 Photodetector with High speed and energy efficient (2022)

Here we presented a waveguide integrated plasmonic MoTe 2 based photodetector with the new design to accomplish high speed (300 GHz) energy efficient (0.8 AW -1 ) detection of light at 1310 nm.