gebhart/patrepeval huggingface dataset:
Dark Matter Search in a Beam-Dump eXperiment (BDX) at Jefferson Lab (2016)

MeV-GeV dark matter (DM) is theoretically well motivated but remarkably unexplored. This proposal presents the MeV-GeV DM discovery potential for a $\sim$1 m$^3$ segmented CsI(Tl) scintillator detector placed downstream of the Hall A beam-dump at Jefferson Lab, receiving up to 10$^{22}$ electrons-on-target (EOT) in 285 days. This experiment (Beam-Dump eXperiment or BDX) would be sensitive to elastic DM-electron and to inelastic DM scattering at the level of 10 counts per year, reaching the limit of the neutrino irreducible background. The distinct signature of a DM interaction will be an electromagnetic shower of few hundreds of MeV, together with a reduced activity in the surrounding active veto counters. A detailed description of the DM particle $\chi$ production in the dump and subsequent interaction in the detector has been performed by means of Monte Carlo simulations. Different approaches have been used to evaluate the expected backgrounds: the cosmogenic background has been extrapolated from the results obtained with a prototype detector running at INFN-LNS (Italy), while the beam-related background has been evaluated by GEANT4 Monte Carlo simulations. The proposed experiment will be sensitive to large regions of DM parameter space, exceeding the discovery potential of existing and planned experiments in the MeV-GeV DM mass range by up to two orders of magnitude.
GPDM- and 10-MDP-based Self-etch Adhesives Bonded to Bur-cut and Uncut Enamel - "Immediate" and "Aged" µTBS. (2018)

The best bonding efficacy to enamel is still achieved by etching with phosphoric acid, following an E&R approach, while the higher etching efficacy of the GPDM-based SEA may result in equally effective bonding, provided that the enamel is bur-roughened first.
Configurable FPGA-Based Firing Circuit For Single/Three Phase AC Controller (2009)

In this paper, a configurable single chip firing circuit for three phase motor speed control based on Field Programmable Gate Array (FPGA) hardware architecture is presented. The proposed circuit is designed, implemented and tested using MAX II PLD chip (EPM1270F256C5 device). The system has the advantages of being simple, flexible and low development cost with built-in self test. The experimental results carried out using Altera development kit showed that the proposed scheme works properly.
Efficient Cross-Coupling of Functionalized Arylzinc Halides Catalyzed by a Nickel Chloride−Diethyl Phosphite System (2005)

[reaction: see text] The combination of diethyl phosphite and DMAP as ligands for nickel in an 8:1 THF-N-ethylpyrrolidinone (NEP) mixture allows a very efficient cross-coupling reaction to be performed between various functionalized arylzinc halides and aryl bromides, triflates and activated chlorides. The reaction proceeds at 25 degrees C within 1-48 h and requires only 0.05 mol % of the nickel catalyst.
Effects of Re Alloying on Mechanical Properties of In-Situ Composites with Base Composition of Nb-18Si-2HfC (2006)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Assessment of Minimally Invasive Device That Provides Simultaneous Adjustable Cardiac Support and Active Synchronous Assist in an Acute Heart Failure Model (2011)

Congestive heart failure (CHF) is a debilitating disease that is generally initiated by some index cardiac event and ultimately characterized by left ventricular (LV) remodeling which dramatically alters the mechanical environment about the heart. It is well established that mechanical stimuli (e.g., stress or strain) are important epigenetic factors in cardiovascular development, adaptation, and disease.1–3 Interestingly, abnormal cardiac kinematics is often considered a symptom of heart failure when in actuality it is likely a primary contributing factor to the relentless progression of the disease.4 Cellular responses to pathologic mechanical factors lead to further pathologic remodeling and a positive feedback loop emerges such that eventually a threshold is reached wherein the neurohormal compensatory mechanisms activated to maintain homeostasis following the initial cardiac event are no longer sufficient to deter further progression of the disease. Consequently, treatment strategies that fail to remedy the aberrant mechanical environment become increasingly ineffective as the disease progresses.
Two Amphoteric Silver Carbene Clusters (2018)

Abstract Two highly labile silver carbene cluster complexes are described, which are unique in that they mark the transition point at which the carbene center transmutes from a fairly common NHC‐like nucleophilic behavior to an electrophilic character befitting reactive silver carbene intermediates of relevance in various catalytic transformations. This amphoteric character is the distinguishing attribute of a μ‐bridged donor/donor carbene entity that connects two silver atoms of triangular or tetrahedral metallic core units.
Serum Pleiotrophin Is a New Multiple Myeloma Tumor Marker That Also Predicts Clinical Status. (2005)

Abstract Pleiotrophin (PTN), an 18 kD heparin-binding protein, has been found to be expressed in some solid tumors whereas it has not been previously evaluated in hematologic malignancies. Constitutive expression of PTN promotes tumor expansion and may increase metastatic potential. This protein binds to syndecan-1 (CD138) and stimulates angiogenesis. Its role in multiple myeloma (MM), thus far, has not been evaluated. Recently, we showed that PTN was strongly expressed in MM cell lines and malignant plasma cells from fresh bone marrow samples but not in normal control bone marrow specimens. Since PTN has been shown to be elevated in the serum of some solid tumor patients, we determined whether PTN may be elevated in the serum of MM patients, and correlated these levels with the patients’ disease status. By using a highly sensitive and specific enzyme-liked immunosorbent assay (ELISA) for PTN, we tested 270 different serum samples [MM (n=194), MGUS (n=18) and age-matched healthy control subjects (n=58)]. Serum samples from MM patients were obtained at the time of diagnosis as well as during the course of their disease. Serum PTN levels were higher in MM patients than in the control subjects (median=1.44 ng/ml vs 0.42 ng/ml, p &amp;lt;0.0001). In addition, among patients with MGUS and smoldering myeloma, serum PTN was also higher than in the controls (median=1.14 ng/ml vs 0.42 ng/ml, p &amp;lt;0.0001) but lower than among patients with active MM (p &amp;lt;0.0001). Patients with untreated MM showed serum PTN levels similar to those patients who received prior treatment. Among previously treated patients, the group with progressive disease at the time of evaluating their PTN level had higher serum concentrations of this protein than patients with responsive or stable disease (median=1.73 ng/ml vs 1.16 ng/ml, p &amp;lt;0.0001). Evaluation of patients who had a change in disease status showed that the serum PTN level increased at the time of progression when compared with their baseline level (median=1.76 ng/ml vs 1.01 ng/ml, p=0.009). Conversely, patients who responded to anti-MM therapy exhibited significant decreases of PTN as compared with their pre-treatment PTN values (median=0.95 ng/ml vs 1.90 ng/ml, p=0.007). These results suggest that serum PTN may be a new tumor marker for MM, and monitoring of this protein may be useful to follow the responsiveness to therapy and disease status of MM patients. We are now undertaking studies to evaluate PTN as a prognostic marker in a large cohort of newly diagnosed MM patients.
A novel lipid A from <i>Halomonas magadiensis</i> inhibits enteric LPS‐induced human monocyte activation (2005)

Lipopolysaccharide (LPS) endotoxin is the bacterial product responsible for the clinical syndrome of Gram-negative septicemia and endotoxic shock. During sepsis, microbial antigens, such as LPS, activate monocytes and macrophages to produce several pro-inflammatory cytokines, among which tumor necrosis factor-alpha (TNF-alpha) appears to be very important for the development of endotoxic shock. The endotoxic properties of LPS principally reside in the lipid A (LIP A) component, which is the primary immunostimulatory center of Gram-negative bacteria. In recent years there has been a continuous effort to identify molecules able to antagonize the deleterious effects of endotoxic shock. In this study we show that a novel LIP A fraction from the LPS of Halomonas magadiensis (Hm), a Gram-negative extremophilic and alkaliphilic bacterium, significantly inhibits the synthesis of TNF-alpha by human monocytes activated by Escherichia coli LPS. LIP A from Hm exerts these effects by interfering with E. coli LPS for activation of Toll-like receptor 4 expressed in human cells. This result defines Hm LIP A as a novel class of LPS antagonist whose structural features could be utilized for the design of compounds for the treatment of Gram-negative sepsis.
Three-Dimensional Meta-films ? A Discovery Platform for Structured Electromagnetic Materials. (2021)

Abstract not provided.
Role of the interfacial asymmetric spin scattering at ferromagnet-Pt interfaces. (2020)

Understanding the spin transport at interfaces is essential to develop spinorbitronics. Here, we measure spin-charge interconversion in ferromagnetic/Pt nanodevices. The spin signals and the extracted effective spin Hall angles of Pt evolve drastically with the ferromagnetic materials (CoFe, Co, and Py). By assuming transparent or non-polarized interfaces, we cannot provide a coherent understanding of the high values observed. We show that a well-known but usually overlooked interfacial parameter, the asymmetric spin scattering, has to be taken into account. These results suggest that looking for transparent interfaces is not necessary for the best route towards high spin signals.
DPPX autoimmune encephalitis presenting with chronic diarrhea, multidirectional nystagmus, opsoclonus and prominent hyperekplexia (5154) (2020)

To highlight the classical clinical features and diagnostic challenges associated with Dipeptidyl peptidase like protein-6 (DPPX) encephalitis in a patient who was treated at Mayo Clinic Arizona.
Image-based separation of diffuse and specular reflections using environmental structured illumination (2009)

We present an image-based method for separating diffuse and specular reflections using environmental structured illumination. Two types of structured illumination are discussed: phase-shifted sine wave patterns, and phase-shifted binary stripe patterns. In both cases the low-pass filtering nature of diffuse reflections is utilized to separate the reflection components. We illustrate our method on a wide range of example scenes and applications.
Abstract B33: PKC resistance in uveal melanoma is mediated by activation of AKT and reversed by BYL719, the PI3Kα inhibitor (2015)

Abstract Uveal melanoma is the one of most common intraocular malignancies of the adult eye. Recently, Protein Kinase C (PKC) inhibitors have been used, as single agent and in combination, to treat GNAQ/GNA11-mutant uveal melanoma. However, patients may develop resistance to drug therapy. We have studied mechanisms of PKC resistance in uveal melanoma by exposing GNAQ/GNA11 mutant cell lines (92.1, Omm1.3 and Omm1) to increasing concentrations of the PKC inhibitor AEB071 for extended periods of time. Cell survival, as measured by cell proliferation assays, indicates IC50s of &amp;gt; 5μM, ten times higher than the sensitive parental cells. Western blot analysis indicates increased expression of p-MARCKS (the PKC substrate), p-ERK and p-AKT in the resistant cells. When treated with AEB071, there was no evidence of PKC enzyme inhibition and no suppression of p-MARCKS, p-ERK or p-AKT. Though resistant to AEB071, treatment of the resistant cells with BYL719, a PI3Kα inhibitor, shows inhibition of cell growth (IC50s between 1 and 2 μM) with inhibition of p-AKT similar to that of the parental cells. Furthermore, this effect on growth inhibition can be enhanced by combining AEB071 with BYL719 resulting in inhibition of p-ERK, p-S6 and p-AKT despite persistent activation of p-MARCKS. Analysis of p-glycoprotein (MDR) in the PKC resistant cell lines showed no differences when compared to the parental cell lines, suggesting that this effect is not due to differences in drug accumulation. These studies support the combination of AEB071 and BYL719 as a means to maintain sensitization to PKC inhibitor therapy despite the onset of drug resistance. A clinical trial with AEB071 and BYL719 will be initiated shortly. Citation Format: Elgilda Musi, Grazia Ambrosini, Gary K. Schwartz. PKC resistance in uveal melanoma is mediated by activation of AKT and reversed by BYL719, the PI3Kα inhibitor. [abstract]. In: Proceedings of the AACR Special Conference on Advances in Melanoma: From Biology to Therapy; Sep 20-23, 2014; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(14 Suppl):Abstract nr B33.
Decreasing Iron Content In Fertilizer-Grade Phosphoric Acid Using Ion Exchange Method (2006)

In Egypt, concentrated wet-process phosphoric acid is produced from phosphate concentrate by the conventional dihydrate process in which phosphate concentrate leached with sulfuric and weak phosphoric acids. It is an important intermediate product for production of phosphatic fertilizers. The produced acid contains iron ranging from 2.0 % to 4.0 % Fe2O3 as inorganic impurity and 48% P2O5. Ion-exchange method is used to reduce the concentration of ferric ions content. Ferric ions affect the quality of produced fertilizers as they combine with P2O5 and form insoluble compounds. Decreasing Fe2O3 content to less than 1.0% was achieved by reaction of fertilizer-grade phosphoric acid with strong acid cation exchanger (Dowex-50). The following optimum reaction conditions were determined: 30°C reaction temperature, 30 min. raction time, 1.25 weight ratio of cation-exchange resin to acid and 28 % P2O5 from acid concentration. These conditions lead to removal of 80.3 % from Fe2O3 in the treated acid. Reduction of ferric ions to ferrous ions is a must for higher Fe2O3 removal efficiency. Also, regeneration conditions of loaded resin were systematically studied.
Bandwidth allocation for bursty isochronous traffic in a hybrid switching system (1989)

Consideration is given to a hybrid switch which provides integrated packet and circuit switching. The statistical characteristics of the bandwidth utilized by bursty isochronous traffic are derived. The derivation takes into consideration the waste inherent in the framing structure. Bursty traffic due to circuit allocation requests is modeled by a switched Poisson process. The analysis is performed for two circuit allocation policies, namely, repacking and first-fit with static numbering. Numerical results are presented to demonstrate the effect of traffic burstiness on the capacity utilized by the isochronous traffic.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electrostatics of metal-graphene interfaces: sharp p-n junctions for electron-optical applications (2019)

Creation of sharp lateral p-n junctions in graphene devices, with transition widths w well below the Fermi wavelength λF of graphene’s charge carriers, is vital to study and exploit these electronic systems for electron-optical applications. The achievement of such junctions is, however, not trivial due to the presence of a considerable out-of-plane electric field in lateral p-n junctions, resulting in large widths. Metal-graphene interfaces represent a novel, promising and easy to implement technique to engineer such sharp lateral p-n junctions in graphene field-effect devices, in clear contrast to the much wider (i.e. smooth) junctions achieved via conventional local gating. In this work, we present a systematic and robust investigation of the electrostatic problem of metal-induced lateral p-n junctions in gated graphene devices for electron-optics applications, systems where the dependence of the width w of the created junctions is not only determined by the metal used but also on external factors such as device geometries, dielectric environment and different operational parameters such as carrier density and temperature. Our calculations demonstrate that sharp junctions (w << λF) can be achieved via metal-graphene interfaces at room temperature in non-encapsulated devices surrounded by dielectric media with low relative permittivity (<10). In addition, we show how specific details such as the separation distance between metal and graphene and the permittivity of the gap in-between plays a critical role when defining the p-n junction, not only defining its width w but also the energy shift of graphene underneath the metal. These results can be extended to any two-dimensional (2D) electronic system doped by the presence of metal clusters and thus are relevant for understanding interfaces between metals and other 2D materials.
All-Blood (Miniplegia) Versus Dilute Cardioplegia in Experimental Surgical Revascularization of Evolving Infarction (2001)

Background The advantages of blood cardioplegia include the oxygen-carrying capacity, superior oncotic and buffering properties, and endogenous antioxidants contained in blood. However, the partial dilution of blood in 4:1 (blood:crystalloid) cardioplegic solutions may nullify these advantages and progressively dilute blood during continuous retrograde delivery. This study tested the hypothesis that all-blood (66:1) cardioplegia provides superior myocardial protection compared with dilute (4:1) cardioplegia delivered in a continuous retrograde modality during surgical reperfusion of evolving myocardial infarction. Methods and Results After 60 minutes of left anterior descending coronary artery (LAD) occlusion, anesthetized canines were placed on cardiopulmonary bypass and randomized to either all-blood cardioplegia (AB group) or dilute blood cardioplegia (Dil group). After cross clamping, arrest was induced with 5 minutes of tepid (30°C) antegrade potassium all-blood or dilute blood cardioplegia and maintained with tepid retrograde coronary sinus cardioplegia for a total of 1 hour. The LAD was released after 30 minutes of arrest, simulating revascularization. The cardioplegia hematocrit for the Dil group was lower than that for the AB group (7±1% versus 12±2%, P &lt;0.05); at the end of bypass, systemic hematocrit was lower in the Dil group than in the Ab group (15±1% versus 20±1%, P &lt;0.05). Infarct size (triphenyltetrazolium chloride staining) was comparable between the AB and Dil groups (29.6±2.9% versus 30.3±3.9% of area at risk), and there was no difference in area-at-risk myocardium systolic shortening (by sonomicrometry, −0.3±1% versus −0.4±1%). Tissue edema after bypass tended to be greater in the Dil group compared with the AB group in the heart (82±0% versus 81±1%), lung (79±1% versus 78±1%), liver (75±1% versus 74±0%), and skeletal muscle (76±1% versus 73±2%) and was significantly greater in the duodenum (80±1% versus 79±1%, P &lt;0.05) and kidney (82±1% versus 79±1%, P &lt;0.05). Postexperimental endothelial function (relaxation of acetylcholine) was impaired in LADs of the AB group versus the Dil group (59±6% versus 77±5%, P &lt;0.05). Conclusions Both all-blood cardioplegia and dilute cardioplegia have disadvantages, but these do not have an impact on the pathogenesis of infarct size or recovery of regional contractile function.
Unification factoring for efficient execution of logic programs (1995)

The efficiency of resolution-based logic programming languages, such as Prolog, depends critically on selecting and executing sets of applicable clause heads to resolve against subgoals. Traditional approaches to this problem have focused on using indexing to determine the smallest possible applicable set. Despite their usefulness, these approaches ignore the non-determinism inherent in many programming languages to the extent that they do not attempt to optimize execution after the applicable set theory has been determined.
Economic Analysis of Influenza Vaccination and Antiviral Treatment for Healthy Working Adults (2002)

Vaccination is cost-beneficial in most influenza seasons in healthy working adults. Although the benefits of antiviral therapy for persons with influenza infection appear to justify its cost, head-to-head trials of the various antiviral therapies are needed to determine the optimal treatment strategy.
High resolution NMR in solids (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh resolution NMR in solidsR. G. GriffinCite this: Anal. Chem. 1977, 49, 11, 951A–960APublication Date (Print):September 1, 1977Publication History Published online21 September 2008Published inissue 1 September 1977https://pubs.acs.org/doi/10.1021/ac50019a003https://doi.org/10.1021/ac50019a003research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Characterizing Universal Reconfigurability of Modular Pivoting Robots (2020)

We give both efficient algorithms and hardness results for reconfiguring between two connected configurations of modules in the hexagonal grid. The reconfiguration moves that we consider are "pivots", where a hexagonal module rotates around a vertex shared with another module. Following prior work on modular robots, we define two natural sets of hexagon pivoting moves of increasing power: restricted and monkey moves. When we allow both moves, we present the first universal reconfiguration algorithm, which transforms between any two connected configurations using $O(n^3)$ monkey moves. This result strongly contrasts the analogous problem for squares, where there are rigid examples that do not have a single pivoting move preserving connectivity. On the other hand, if we only allow restricted moves, we prove that the reconfiguration problem becomes PSPACE-complete. Moreover, we show that, in contrast to hexagons, the reconfiguration problem for pivoting squares is PSPACE-complete regardless of the set of pivoting moves allowed. In the process, we strengthen the reduction framework of Demaine et al. [FUN'18] that we consider of independent interest.