gebhart/patrepeval huggingface dataset:
Outcome of patients with clinically node-positive bladder cancer who undergo consolidative surgery after preoperative chemotherapy: MD Anderson Cancer Center experience. (2014)

318 Background: We previously reported results of our phase II study in patients with retroperitoneal lymph node (RPLN) metastasis from bladder cancer (BC) undergoing consolidative surgery after preoperative chemotherapy. Here we present an expanded cohort of patients who underwent consolidative surgery after chemotherapy for clinically node-positive BC. Methods: We reviewed results of patients from our IRB approved protocol including those with clinical evidence of nodal metastasis in the pelvis or retroperitoneum (M1), without visceral metastasis, from 1995-2010. Endpoint of the study was cancer-specific survival (CSS) calculated from time of surgery. Results: 55 patients with either clinical pelvic lymph node (PLN) metastasis (n=29) or PLN and RPLN metastasis (n=26) were identified. Median CSS was 19 months for all patients; 21 for PLN alone and 16 for PLN and RPLN disease. Kaplan-Meier estimate of 5-year CSS was 31% with no difference between PLN alone and PLN with RPLN disease. Clinical nodal stage was N1: 16, N2: 5, N3: 8, and M1 (RPLN): 26. Majority (94%) of patients received cisplatinum-based chemotherapy. At cystectomy, all patients underwent a PLN dissection with 12 patients (all clinical M1 RPLN) undergoing concurrent RPLN dissection (RPLND). In all, 30 of 55 (55%) patients were pN0 at the time of surgical extirpation while 26% (5 of 19) were pN+ despite radiologic complete response after chemotherapy. 5-year CSS was 57% for pN0 and 9% for pN+ disease (p&lt;0.0001). Median survival in patients with residual tumor in PLN (n=17) was 10.5 months vs. 7 months for RPLN (n=8) (median survival not reached in pN0 patients, p&lt; 0.001). 17 patients developed recurrences outside the surgical field after a median of 8 months. While no recurrences occurred within the lymphadenectomy template, 14% of patients with clinical M1 RPLN disease who did not undergo RPLND had recurrences in RPLN basin. Conclusions: Post-chemotherapy consolidative surgical resection may result in 5-year disease-free survival in patients with clinical evidence of node-positive disease, including those with RPLN positive disease, who have major response to chemotherapy.
On line reactive planning for a nonholonomic mobile in a dynamic world (2002)

The problem of planning and controlling the motion of a car-like moving object in a dynamic and roadway-like environment is addressed. A motion controller that executes in a reactive way a given nominal motion plan is presented. Data concerning the actual environment of the vehicle considered are assumed to be obtained through perception. In order to get the required reactivity, a motion controller is developed which has two main components: the pilot which analyzes the current situation and adapts the nominal plan accordingly, and the executor which generates the required motion commands. The pilot operates at a symbolic level using a set of behavioral rules. The executor makes use of a potential field approach to generate the motion commands.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Boundary tracking using a suboptimal sliding mode algorithm (2014)

In this paper, a sliding mode control algorithm is proposed that allows a single, sensor enabled agent to navigate along the boundary of a contaminated region. The proposed control algorithm only requires knowledge of the local measurement of the scalar field. No gradient information is required for the spatial phenomenon and this distinguishes this work from much of the existing literature. The efficacy of the proposed approach is demonstrated using synthetic volcanic eruption dispersion data made available from a complex Lagrangian model.
Dual Infection of HIV‐1 and HTLV‐I in South India: A Study on a Patient with AIDS‐Related Complex (1993)

A dually HIV- and HTLV-infected ARC patient was found by serological studies in South India. These viruses were isolated and molecular study showed that the patient had both HIV-1 and HTLV-I but not HIV-2 and HTLV-II. In addition to this, 9 other dually infected persons which include another full-blown AIDS case have been identified as on July 1993 in South India. Our findings provide an opportunity to clarify geographical distribution of these human retroviruses.
Effect of cooldown and residual magnetic field on the performance of niobium–copper clad superconducting radio-frequency cavity (2017)

Here, we present the results of rf measurements on a niobium–copper clad superconducting radio-frequency cavity with different cooldown conditions and residual magnetic field in a vertical test Dewar in order to explore the effect of thermal current induced magnetic field and its trapping on the performance of the cavity. The residual resistance, extracted from the Q <sub>0</sub>(<i>T</i>) curves in the temperature range 4.3–1.5 K, showed no dependence on a temperature gradient along the cavity during the cooldown across the critical temperature up to ~50 K m<sup>–1</sup>. The rf losses due to the trapping of residual magnetic field during the cavity cooldown were found to be ~4.3 nΩ <i>μ</i>T<sup>–1</sup>, comparable to the values measured in bulk niobium cavities. An increase of residual resistance following multiple cavity quenches was observed along with evidence of trapping of magnetic flux generated by thermoelectric currents.
A stimulation test with calcitonin for differential diagnosis of hypercalcaemia (1984)

Experimental studies have suggested that in primary hyperparathyroidism (HPT) the cells of the hyperfunctioning parathyroid tissue retain some capacity for stimulation and that an increase in secretion of parathyroid hormone (PTH) can occur when the extracellular calcium concentration is lowered within the hypercalcaemic range. We have tested this hypothesis in 23 patients with HPT, 10 patients with hypercalcaemia of other origin (7 of whom had disseminated malignant disease) and 17 normal subjects. In all three groups a single injection of 100 MRC units of salmon calcitonin caused a reduction in serum calcium of approximately 3 to 5%. In the hypercalcaemic patients this reduction was correlated to the basal calcium level (r = -0.57, P less than 0.01). In the patients with HPT, although they all remained hypercalcaemic, the decrease in serum calcium was associated with a mean increase in serum PTH of 10%. Only in 2 patients did such an increase fail to occur despite an adequate decrease in serum calcium. These 2 patients had high basal PTH levels and the lack of response might have been due to a high degree of autonomous parathyroid function. Calcitonin also reduced serum calcium and increased serum PTH in normal subjects. None of the patients with hypercalcaemia of other origin than primary HPT displayed a secretory PTH response to serum calcium reduction. Thus, this test could be of practical clinical value, particularly in patients with borderline PTH values. A calcitonin-induced rise in PTH while serum calcium is lowered within the hypercalcaemic range strongly suggests primary HPT.
ChemInform Abstract: 2‐INDOLYL KETONE SYNTHESIS (1979)

Abstract Aus den 3‐Hydroxy‐indolen (I) entstehen die Sulfonylketone (II), die zu (III) substituiert werden können und dann zu (IV) entschwefelt werden.
Coupled 3D Transient Magneto-Mechanical FEM Simulation of a Short Circuit Test on a Mock-up of a 570 MVA Transformer Unit (2017)

Large generator step-up (GSU) transformer units are particularly important components of the power generation network. In order to ensure a reliable functioning of the power network, GSU transformers have to be able to withstand a wide variety of stresses, of which Lorentz forces generated during an external short-circuit can be potentially dangerous for the transformer. In this case, a reference mock-up unit designed to withstand similar mechanical stress underwent the actual short circuit testing. Upon the demonstration of short-circuit withstand capability of the mock-up unit, a destructive test was undertaken in order to demonstrate the safety margin of the design. This was achieved by gradually increasing the current until mechanical deformations occurred. This paper describes the process of model generation, calculation, numerical behaviour and the results of a 3D transient magneto-mechanical FEM simulation of the winding assembly of the mock-up transformer unit. This unit underwent short circuit testing with the standard short circuit test currents. This type of simulation allows for a deeper insight into the actual generation and distribution of the magnetic forces and the resulting mechanical stresses during a short circuit which cannot be achieved by presently used simulation and calculation methods used in the calculation of the short circuit withstand capability of power transformer.
Road map for the development of an e-healthcare strategy. (2001)

This article presents a case study describing how Saint Francis Care developed its strategy for using the Internet and e-commerce. Planning strategies are discussed, as are implementation plans and expected benefits.
Abstract P2-22-03: Effect of miR-660-5p in breast cancer progression (2023)

Abstract Background: Breast cancer (BC) is the most diagnosed cancer in women worldwide. MicroRNAs (miRNAs) are involved in different processes of BC and their deregulation can cause them to act as oncogenes or tumor suppressors, participating in cancer progression or also as therapeutic target. Using The Cancer Genome Atlas (TCGA) database, we found that miR-660-5p is significantly overexpressed and associated with poor survival in patients with this pathology. Moreover, it is reported that miR-660-5p can induce BC progression through transcription factor CP2 (TFCP2) and the down regulation of tet-eleven translocation 2 (TET2). In this project, we propose to identify the role of miR-660-5p in proliferation, migration, invasion, angiogenesis, and possible targets involved in these processes in BC cell lines. Methods: Basal levels of miR-660-5p were determined in BC cells MDA-MB-231 and MCF-7, and in human epithelial breast cells MCF-10A by RT-qPCR. The effect of miR-660-5p was evaluated on proliferation, migration, and invasion processes using MDA-MB-231 and MCF-7 cells. HUVEC cells were used to assess angiogenesis. All cell lines were transfected with miR-660-5p inhibitor. Analysis of nine miRNA-target prediction databases was made to identify targets of miR-660-5p. We selected the target genes predicted by at least three of these programs, and their expression was evaluated by RT-qPCR in a customized 384-well plate. Results: We found that miR-660-5p is significantly upregulated in MDA-MB-231 and MCF-7, compared to MCF-10A cells. In addition, we observed a significant decrease in proliferation, migration, and invasion of BC cells transfected with miR-660-5p inhibitor, compared to non-treated cells and miRNA inhibitor negative control treated cells. Similarly, we observed a significant decrease in angiogenesis of HUVEC cells transfected with miR-660-5p inhibitor. Furthermore, of all the miR-660-5p targets identified by prediction databases 21 were selected, and of these, 7 were observed upregulated and 1 downregulated. Conclusions: The results show that miR-660-5p is upregulated and involved in proliferation, migration, invasion, and angiogenesis of BC, which may lead us to suggest that this miRNA act as an onco-miRNA. In addition, seven potential miR-660-5p target genes were identified, but further validation assays are needed to clarify their implication in this disease. Citation Format: Valeria Villarreal-García, José Roberto Estupiñan Jimenez, Ricardo Noriega, Recep Bayraktar, Diana Reséndez-Pérez, Cristina Rodríguez-Padilla, José Manuel Vázquez-Guillén, Gabriel Lopez-Berestein, Pablo E. Vivas-Mejía, Vianey Gonzalez-Villasana. Effect of miR-660-5p in breast cancer progression [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr P2-22-03.
The Influence of CSI in Ultra-Reliable Low-Latency Communications with IR-HARQ (2019)

Emerging 5G networks will need to efficiently support ultra-reliable, low-latency communication (URLLC), which requires extremely low latency (at msec order) with very high reliability (99.999%). In this work, we consider a URLLC system with incremental redundancy hybrid automatic repeat request (IR-HARQ) and investigate the effect of channel state information (CSI) at the transmitter on throughput and energy consumption optimization. For that, we analyze the feasibility region and the performance in block fading channels for the cases of full and statistical CSI. Our results show that in our setup the full CSI scheme is less robust and we also reveal a desirable balance between the trade-off quantities of energy and throughput.
Study on yttria stabilized zirconia electrolyte and gadolinia-doped ceria barrier layer deposited by d.c. magnetron sputtering under reactive conditions (2016)

International audience
Quasi-phase-matched second-harmonic generation in LiNbO3 waveguides (1990)

Nonlinear frequency conversion is an attractive technique for extending the spectral range of solid-state coherent sources. Waveguide interactions are useful to increase the efficiency of devices based on low-power pump lasers, e.g. second harmonic generation (SHG) of the output of AlGaAs laser diodes to produce blue light. While the large nonlinear susceptibility and well-developed waveguide technologies available in LiNbO 3 are attractive for device design, LiNbO 3 does not have adequate birefringence for phasematching SHG of blue light. Compensating for phase-velocity mismatch by reversing the sign of the nonlinear susceptibility with a period equal to the coherence length, quasi-phase-matching (QPM), allows phase-matching of any interaction within the transparency range of the crystal using the large d 33 nonlinear coefficient. QPM has been investigated in LiNbO 3 waveguides, where the sign changes were due to periodic reversal of the orientation of the ferroelectric domains accomplished by a patterned doping process. 1-3 We have succeeded in generating green and blue light by QPM SHG of the output of infrared lasers in such waveguides.
Centroidal Momentum Matrix of a humanoid robot: Structure and properties (2008)

The centroidal momentum of a humanoid robot is the sum of the individual link momenta, after projecting each to the robotpsilas Center of Mass (CoM). Centroidal momentum is a linear function of the robotpsilas generalized velocities and the centroidal momentum matrix is the matrix form of this function. This matrix has been called both a Jacobian matrix and an inertia matrix by others. We show that it is actually a product of a Jacobian and an inertia matrix.
Ventricular Resynchronization (2004)

ardiac resynchronization therapy (CRT) is a new therapy that improves hemodynamics and symptoms in patients with advanced heart failure (HF). Resynchronization pacing can influence hemodynamics by improving mechanical synchrony both between and within the right and left ventricles, as well as by optimizing atrioventricular synchrony. Biventricular pacing devices, first implanted in 1994, were approved by the U.S. Food and Drug Administration in 2001. Currently available devices may also have defibrillation capacity. Much of the information regarding the clinical benefits of CRT derives from clinical trials 2-4 (Table ) that together demonstrate that CRT improves symptoms and exercise tolerance in medically treated patients with persistent, moderate to severe symptoms of HF; poor left ventricular (LV) function; and intraventricular conduction delay. The relatively few scenarios in which this modality has been studied make it possible to argue both for broadening and restricting the use of these devices until further trials are conducted. Here we review the proposed mechanisms of action, potential applicability, and cost impact of CRT of appropriately selected patients.
Comparison in vivo applications between peripheral blood-derived mesenchymal stromal cells (PB-MSCs) and platlet-rich plasma (PRP) in injured tendons of sheep (2012)

Performance horses are most at risk of tendon injuries, degenerative tendinopathy and overuse tendinitis. Novel therapies aim to restore tendon functionality by means of cell-based therapy, growth factor delivery and tissue engineering approaches. This study examined the use of autologous mesenchymal stromal cells derived from peripheral blood (PB-MSCs), platelet rich plasma (PRP) and a combination of both for ameliorating experimental lesions on deep digital flexor tendons (DDFT) of Bergamasca sheep. In particular, testing the combination of blood-derived MSCs and PRP in an experimental animal model represents one of the few studies exploring a putative synergistic action of these treatments. Effectiveness of treatments was evaluated at 30 and 120 days comparing clinical, ultrasonographic and histological features together with immunohistochemical expression of collagen types 1 and 3, and cartilage oligomeric matrix protein (COMP). Significant differences were found between treated groups and their corresponding controls (placebo) regarding tendon morphology and extracellular matrix (ECM) composition. Our results indicate that the combined use of PRP and MSCs did not produce an additive or synergistic regenerative response and highlighted the predominant effect of MSCs on tendon healing.
Hydrothermal synthesis and structural characterization of prototypical organic–inorganic hybrid materials: [{Cu(2,2′-bpy)(H2O)}(VO)(O3PCH2PO3)], [Cu(2,2′-bpy)(VO)(O3PCH2CH2PO3)], and [Cu(2,2′-bpy)(VO)(O3PCH2CH2CH2PO3)]·H2O. Bimetallic phosphonate networks with surface-modifying organic subunits (2000)

Hydrothermal reactions of Cu2O or CuCl2 with Na3VO4, 2,2′-bipyridine and the appropriate organodiphosphonate yielded the bimetallic, two-dimensional phosphonate phases, [{Cu(2,2′-bpy)(H2O)}(VO)(O3PCH2PO3)], [Cu(2,2′-bpy)(VO)(O3PCH2CH2PO3)] and [Cu(2,2′-bpy)(VO)(O3PCH2CH2CH2PO3)]·H2O.
Assignment of the integration site for simian virus 40 to chromosome 17 in GM54VA, a human cell line transformed by simian virus 40. (1977)

GM54VA human cells transformed by simian virus 40 (SV40) were fused with peritoneal macrophages obtained from three different mouse strains. All 27 hybrid clones studied were positive for SV40 tumor antigen in 100% of their cells and contained human chromosome 17. Human chromosome 17 was the only human chromosome present in five of the hybrid clones. Fusion of GM54VA cells and either thymidine kinase (EC 2.7.1.75)-deficient mouse or Chinese hamster fibroblasts resulted in the growth in hypoxanthine-aminopterin-thymidine medium of hybrid clones positive and negative for SV40 tumor antigen. Counterselection of the hybrid clones positive for tumor antigen in medium containing 5-bromodeoxyuridine resulted in the growth of hybrid cells that were negative for tumor antigen. These experiments indicate that negative for tumor antigen. These experiments indicate that SV40 is integrated in only one of the two parental human chromosomes 17. Because the genome of SV40 has been assigned to human chromosome 7 in two other SV40-transformed human cell lines, at least two different integration sites for SV40 would seem to be present in human cells: one located in human chromosome 7 and the other located in human chromosome 17.
Development of a model-based transient calibration process for diesel engine electronic control module tables – Part 2: modelling and optimization (2011)

This is the second part of a study investigating a model-based transient calibration process for diesel engines. The first part addressed the data requirements and data processing required for empirical transient emission and torque models. The current work focuses on modelling and optimization. The unexpected result of this investigation is that when trained on transient data, simple regression models perform better than more powerful methods such as neural networks or localized regression. This result has been attributed to extrapolation over data that have estimated rather than measured transient air-handling parameters. The challenges of detecting and preventing extrapolation using statistical methods that work well with steady-state data have been explained. The concept of constraining the distribution of statistical leverage relative to the distribution of the starting solution to prevent extrapolation during the optimization process has been proposed and demonstrated. Separate from the issue of extrapolation is preventing the search from being quasi-static. Second-order linear dynamic constraint models have been proposed to prevent the search from returning solutions that are feasible if each point were run at steady state, but which are unrealistic in a transient sense. Dynamic constraint models translate commanded parameters to actually achieved parameters that then feed into the transient emission and torque models. Combined model inaccuracies have been used to adjust the optimized solutions. To frame the optimization problem within reasonable dimensionality, the coefficients of commanded surfaces that approximate engine tables are adjusted during search iterations, each of which involves simulating the entire transient cycle. The resulting strategy, different from the corresponding manual calibration strategy and resulting in lower emissions and efficiency, is intended to improve rather than replace the manual calibration process.
A DYNAMIC, MECHANISTIC MODEL FOR MEMBRANE BIOREACTOR (MBR) TREATMENT PROCESSES, USING IWA ACTIVATED SLUDGE BIOLOGICAL MODELS (2004)

A DYNAMIC, MECHANISTIC MODEL FOR MEMBRANE BIOREACTOR (MBR) TREATMENT PROCESSES, USING IWA ACTIVATED SLUDGE BIOLOGICAL MODELSMembrane bioreactor (MBR) activated sludge technology has become an increasingly popular choice for the treatment of high-strength, low-flow wastewaters, particularly in the industrial sector. Modeling and simulation are cost-effective tools for optimization of activated sludge processes, and could be applied to MBR plants if a suitably sophisticated MBR process model existed. This paper proposes...Author(s)Spencer SnowlingOliver SchraaJohn B. CoppEvangelia BeliaSourceProceedings of the Water Environment FederationSubjectSession 13: Recycle, Reuse, and Reduction for IndustriesDocument typeConference PaperPublisherWater Environment FederationPrint publication date Jan, 2004ISSN1938-6478SICI1938-6478(20040101)2004:6L.710;1-DOI10.2175/193864704784105715Volume / Issue2004 / 6Content sourceIndustrial Wastes (IW) ConferenceFirst / last page(s)710 - 714Copyright2004Word count127