gebhart/patrepeval huggingface dataset:
EFFECT OF VARIOUS ANTIOXIDANTS ON THE OXIDATIVE STABILITY OF ACID AND ALKALI SOLUBILIZED MUSCLE PROTEIN ISOLATES (2009)

ABSTRACT Protein isolates prepared from cod (Gadus morhua) myofibrillar proteins using acid or alkali solubilization are susceptible to oxidative rancidity. Oxidation could be delayed by the exogenous addition of antioxidants. The objective of this research was to compare the efficacy of antioxidants such as δ-tocopherol, butylated hydroxyanisole (BHA) and propyl gallate, to inhibit oxidation in acid- and alkali- solubilized cod protein isolates. Oxidation was catalyzed using cod hemolysate. Oxidation of lipids was monitored by the measurement of thiobarbituric acid reactive substances and painty odor. Results showed that protein isolates prepared using the acid process was significantly (P < 0.05) more susceptible to lipid oxidation than alkali-solubilized protein isolates. Regardless of pH treatments, the efficacy of various antioxidants decreased in the order propyl gallate > BHA > δ-tocopherol. PRACTICAL APPLICATIONS Research has shown that seafood available for human consumption is rapidly getting depleted and that many fish species may become extinct in the next half-century or so. Acid and alkali solubilization methods are recent but well-known techniques used for preparing protein isolates from under-utilized aquatic species and the by-products of seafood industry. Although numerous researchers have studied the use of acid and alkali processes on several sources of seafood, almost no research has been done on the use of antioxidants to protect protein isolates from lipid oxidation. In our research, we have studied the effect of various antioxidants on the oxidative stability of acid- and alkali-solubilized fish myofibrillar proteins. The results from this work will enable the seafood industry to properly identify the process and the type of antioxidants required for making muscle food products with increased oxidative stability.
Bead Modifications and Wave-Based Substructuring in an automotive NVH optimization scenario (2010)

In automotive industry, Computer-Aided Engineering (CAE) methods are increasingly used to predict the various functional performance attributes (noise and vibration, crashworthiness, etc.) and adapt the design based on the outcome of virtual simulations, such as numerical Finite Element (FE) models. This framework is aimed at testing and validating methodologies for NVH optimizations, based on local modifications that affecting the global dynamic behavior in order to reduce the Sound Pressure Level (SPL). From the entire FE model, built by using linear shell elements, a critical component is firstly individualized and subsequently subject to structural modifications. Bead patterns are created by only acting on the nodal positions according to Mesh Morphing. The combination between modal reduction and Wave-Based Substructuring (WBS) allows fast and accurate NVH predictions, enabling structural optimizations. The proposed procedure is applied on a case study FE model (Concrete Car) from which the spare wheel panel has been selected as critical component. A WBS-reduced representation is achieved, where the panel is still in FE representation enabling modifications on it, while the remainder is reduced. Various optimization approaches, based on different kinds of dynamic analysis, have been tested leading to a significant SPL reduction.
Extensive Recombination among Human Immunodeficiency Virus Type 1 Quasispecies Makes an Important Contribution to Viral Diversity in Individual Patients (2006)

Although recombination during human immunodeficiency virus type 1 (HIV-1) replication in vitro and in vivo has been documented, little information is available concerning the extent that recombination contributes to the diversity of HIV-1 quasispecies in the course of infection in individual patents. To investigate the impact of recombination on viral diversity, we developed a technique that permits the isolation of contemporaneous clonal viral populations resulting from single infectious events by plasma-derived viruses, thereby permitting the assessment of recombination throughout the viral genomes, including widely separated loci, from individual patients. A comparison of the genomic sequences of clonal viruses from six patients, including patients failing treatment with antiretroviral therapy, demonstrated strong evidence for extensive recombination. Recombination increased viral diversity through two distinct mechanisms. First, evolutionary bottlenecks appeared to be restricted to minimal segments of the genome required to obtain selective advantage, thereby preserving diversity in adjacent regions. Second, recombination between adjacent gene segments appeared to generate diversity in both pol and env genes. Thus, the shuffling of resistance mutations within the genes coding for the protease and reverse transcriptase, as well as recombination between these regions, could increase the diversity of drug resistance genotypes. These findings demonstrate that recombination in HIV-1 contributes to the diversity of viral quasispecies by restricting evolutionary bottlenecks to gene segments and by generating novel genotypes in pol and env, supporting the idea that recombination may be critical to adaptive evolution of HIV in the face of constantly moving selective pressures, whether exerted by the immune system or antiretroviral therapy.
Pharmacological validation of TDO as a target for Parkinson’s disease (2021)

Parkinson's disease patients suffer from both motor and nonmotor impairments. There is currently no cure for Parkinson's disease, and the most commonly used treatment, levodopa, only functions as a temporary relief of motor symptoms. Inhibition of the expression of the L-tryptophan-catabolizing enzyme tryptophan 2,3-dioxygenase (TDO) has been shown to inhibit aging-related α-synuclein toxicity in Caenorhabditis elegans. To evaluate TDO inhibition as a potential therapeutic strategy for Parkinson's disease, a brain-penetrable, small molecule TDO inhibitor was developed, referred to as NTRC 3531-0. This compound potently inhibits human and mouse TDO in biochemical and cell-based assays and is selective over IDO1, an evolutionary unrelated enzyme that catalyzes the same reaction. In mice, NTRC 3531-0 increased plasma and brain L-tryptophan levels after oral administration, demonstrating inhibition of TDO activity in vivo. The effect on Parkinson's disease symptoms was evaluated in a rotenone-induced Parkinson's disease mouse model. A structurally dissimilar TDO inhibitor, LM10, was evaluated in parallel. Both inhibitors had beneficial effects on rotenone-induced motor and cognitive dysfunction as well as rotenone-induced dopaminergic cell loss and neuroinflammation in the substantia nigra. Moreover, both inhibitors improved intestinal transit and enhanced colon length, which indicates a reduction of the rotenone-induced intestinal dysfunction. Consistent with this, mice treated with TDO inhibitor showed decreased expression of rotenone-induced glial fibrillary acidic protein, which is a marker of enteric glial cells, and decreased α-synuclein accumulation in the enteric plexus. Our data support TDO inhibition as a potential therapeutic strategy to decrease motor, cognitive, and gastrointestinal symptoms in Parkinson's disease.
The melting behaviour of Ni-Mo-C and Co-Mo-C alloys (1994)

The melting behaviour in selected sections of the ternary systems Ni-Mo-C and Co-Mo-C was investigated by means of differential thermoanalysis, metallography and X-ray diffraction. In the Ni-Mo-C system, a eutectic reaction liquid → Niss + Mo2C + C was observed at 1250 ± 10°C at a composition of 11.5 at % C, 18.5 at % Mo and 70 at % Ni. In the Co-Mo-C system, a eutectic reaction liquid → Mo2C + C + Co was observed at 1170 ± 10°C and a composition of 14 at % C, 16 at % Mo and 70 at % Co. Projections of the liquidus surfaces of the investigated areas of both systems are presented.
A YANG Data Module for Network Virtualization Overlay Resource Management (2018)

This document defines a YANG data module for Network Virtualization
Overlay Resource Management. It is a resource facing model independent
of control plane protocols and captures topological and resource
related information pertaining to Network Virtualization Overlay. This
module enables clients, which interact with a network orchestrator or
controller via a REST interface, for Network Virtualization Overlay
topology related operations such as obtaining and allocating the
relevant topology resource information.
Table S3 from Proteogenomics Uncovers a Vast Repertoire of Shared Tumor-Specific Antigens in Ovarian Cancer (2023)

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First-line intra-arterial versus intravenous chemotherapy in unilateral sporadic group D retinoblastoma: evidence of better visual outcomes, ocular survival and shorter time to success with intra-arterial delivery from retrospective review of 20 years of treatment (2016)

The difference in the time frame between treatment groups had an impact on the availability of intravitreal chemotherapy treatment. Despite this, the results reported here imply that eyes treated with first-line IAC will have shorter treatment period, better ocular survival and visual acuity than first-line IVC.
ChemInform Abstract: POTENTIAL THYROLIBERIN AFFINITY LABELS. 1. CHLOROACETYL‐SUBSTITUTED PHENYLALANYLPYRROLIDINES (1981)

Abstract Ausgehend von den Cyanbenzoesäuren (I) erhält man über die Verbindungen (II)‐(IV) die Benzoesäurechloride (V), die mit den substituierten Pyrrolidinen (IX) bzw. (XV) zu den Pyrrolidinylpeptiden (XIII) bzw. (XVI) umgesetzt werden.
Pharmacology of Transmission and Sites of Drug Action in the Enteric Nervous System (2007)

This chapter contains sections titled: Chemical coding and multiple transmitters Transmitters of motor neurons that innervate the smooth muscle of the gut Transmitters at neuro-neuronal synapses Sites within the reflex circuitry where specific pharmacologies of transmission can be deduced to occur Transmission from entero-endocrine cells to IPANs Roles of interstitial cells of Cajal in neuromuscular transmission Transmitters of secretomotor and vasodilator neurons Synapses in secretomotor and vasodilator pathways Transmitters of motor neurons innervating gastrin cells Summary and conclusions
Diagnosing Root Causes and Generating Graphical Explanations by Integrating Temporal Causal Reasoning and CBR (2017)

This study proposes a methodology to diagnose the root causes of failures in the domain of oil well drilling. The idea is to combine a Bayesian network, which is generated based on an expert knowledge, with situation-specific knowledge of past failure cases. A causal chain is viewed as a temporal sequence. To test the model’s capability, six failure cases from the study’s application domain (oil well drilling) are considered and one of them has been picked up as the studying case. The model is applied to diagnose the root causes of the chosen failure case. A temporal reasoning approach has been employed to narrow down the determination of the effective concepts, given the observations. The preliminary results show some advantages of the new model in comparison with the model that integrated a multi relational knowledge model with case based reasoning.
Space-time multiuser detection in multipath CDMA channels (1999)

The problem of multiuser detection in multipath CDMA channels with receiver antenna array is considered. The optimal space-time multiuser receiver structure is first outlined, followed by linear space-time multiuser detection methods based on iterative interference cancellation. Single user-based space-time processing methods are also considered and are compared with the multiuser approach. It is seen that the proposed multiuser space-time processing techniques offer substantial performance gains over the single-user-based methods, especially in a near-far situation.
Antisense DNA-targeting protein kinase A-RIA subunit: a novel approach to cancer treatment (1999)

Enhanced expression of the RIa subunit of cAMP-dependent protein kinase type I (PKA-I) has been shown during carcinogenesis, in human cancer cell lines and in primary tumors. We demonstrate that the sequence-specific inhibition of RIa gene expression by antisense oligonucleotides results in the differentiation of leukemia cells and growth arrest of cancer cells of epithelial origin and tumors in mice. The loss of RI by the antisense results in rapid increase in the half-life of the competitor molecule, RII protein, via its stabilization in a holoenzyme complex (PKA-II) that insures depletion of PKA-I and sustained inhibition of tumor growth. RI antisense, which restrains tumor cell growth by turning on the signals for blockade of tumor cell survival, namely blockade of the tyrosine kinase signaling, cell cycle deregulation and apoptosis, provides a single gene-targeting approach to treatment of cancer.
Imaging cytochrome C oxidase and FoF1-ATP synthase in mitochondrial cristae of living human cells by FLIM and superresolution microscopy (2017)

Cytochrome C oxidase and FoF1-ATP synthase constitute complex IV and V, respectively, of the five membrane-bound enzymes in mitochondria comprising the respiratory chain. These enzymes are located in the inner mitochondrial membrane (IMM), which exhibits large invaginations called cristae. According to recent cryo-tomography, FoF1-ATP synthases are located predominantly at the rim of the cristae, while cytochrome C oxidases are likely distributed in planar membrane areas of the cristae. Previous FLIM measurements (K. Busch and coworkers) of complex II and III unravelled differences in the local environment of the membrane enzymes in the cristae. Here, we tagged complex IV and V with mNeonGreen and investigated their mitochondrial nano-environment by FLIM and superresolution microscopy in living human cells. Different lifetimes and anisotropy values were found and will be discussed.
A Mobile Coalition Key-Evolving Digital Signature Scheme for Wireless/Mobile Networks (2011)

A scheme is proposed in this chapter to apply a secure digital signature scheme in a mobile-IP environment and treats the three entities in a dynamic path as either foreign agents (FA), home agents (HA) or mobile agents (MA), such that a coalition is formed containing each of the individual agents. Each agent has a pair of keys: one private and one public. The private key is evolving with time, and the public key is signed by a certification authority (CA). All the private keys of the three agents in the coalition are needed to sign a signature. Furthermore, all the messages are signed and verified. The signature is verified against a public key, computed as the product of the public keys of all three agents, and readily generated when a new dynamic path is formed. In addition, the key-evolving scheme prevents an adversary from forging past signatures under any circumstances. As a result of the schemes’ proactive refresh capability, an adversary must simultaneously compromise each MA, FA and HA in order to forge future signatures. When a new dynamic path is formed or private keys evolve to new states, an interactive, proactive synchronization scheme is employed among the agents. Thus, the loss of a mobile device, or its information, will cause minimal information damage.Request access from your librarian to read this chapter's full text.
TU‐D‐209‐03: Alignment of the Patient Graphic Model Using Fluoroscopic Images for Skin Dose Mapping (2016)

Purpose: The Dose Tracking System (DTS) was developed to provide realtime feedback of skin dose and dose rate during interventional fluoroscopic procedures. A color map on a 3D graphic of the patient represents the cumulative dose distribution on the skin. Automated image correlation algorithms are described which use the fluoroscopic procedure images to align and scale the patient graphic for more accurate dose mapping. Methods: Currently, the DTS employs manual patient graphic selection and alignment. To improve the accuracy of dose mapping and automate the software, various methods are explored to extract information about the beam location and patient morphology from the procedure images. To match patient anatomy with a reference projection image, preprocessing is first used, including edge enhancement, edge detection, and contour detection. Template matching algorithms from OpenCV are then employed to find the location of the beam. Once a match is found, the reference graphic is scaled and rotated to fit the patient, using image registration correlation functions in Matlab. The algorithm runs correlation functions for all points and maps all correlation confidences to a surface map. The highest point of correlation is used for alignment and scaling. The transformation data is saved for later model scaling. Results: Anatomic recognition is used to find matching features between model and image and image registration correlation provides for alignment and scaling at any rotation angle with less than onesecond runtime, and at noise levels in excess of 150% of those found in normal procedures. Conclusion: The algorithm provides the necessary scaling and alignment tools to improve the accuracy of dose distribution mapping on the patient graphic with the DTS. Partial support from NIH Grant R01‐EB002873 and Toshiba Medical Systems Corp.
A modified chromium-reducible sulfur method for reduced inorganic sulfur: optimum reaction time for acid sulfate soil (2000)

Reaction times for 16 acid sulfate soil materials analysed using a modified chromium-reducible sulfur method varied between 10 and 15 min, regardless of whether the samples had been dried and ground prior to analysis or were analysed without pretreatment. The reaction time for a ground (&amp;lt;63 mm) pyritic rock sample was 20 min. An optimum reaction time of 20 min is recommended for analysing acid sulfate soil using the modified method; this reaction time is much less than the 1 h reaction time used in previous methods.
Model-based automatic programming for plant control (2002)

A model-based automatic programming system for sequence control is described. The domain knowledge of the application area is discussed and an environment model that represents concepts of the domain-physical entities, actions and states, relations and conditions-in an extended semantic network is proposed. The system also has model-derivation methods. Because it uses a generic model to generate a specific description of the target plant, the system can be applied to the control of any plant of the same type. The model-based approach supports every task in the software life-cycle. As a result, it enables designers to specify control programs using natural terms and concepts. The system was evaluated by generating practical control programs for steel plants. It doubled design productivity while still producing programs that were satisfactory to design experts. These results suggest that at a primary goal of automatic programming research should be the development of models of the domain area.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Advanced and Smart Textiles during and after the COVID-19 Pandemic: Issues, Challenges, and Innovations (2023)

The COVID-19 pandemic has hugely affected the textile and apparel industry. Besides the negative impact due to supply chain disruptions, drop in demand, liquidity problems, and overstocking, this pandemic was found to be a window of opportunity since it accelerated the ongoing digitalization trends and the use of functional materials in the textile industry. This review paper covers the development of smart and advanced textiles that emerged as a response to the outbreak of SARS-CoV-2. We extensively cover the advancements in developing smart textiles that enable monitoring and sensing through electrospun nanofibers and nanogenerators. Additionally, we focus on improving medical textiles mainly through enhanced antiviral capabilities, which play a crucial role in pandemic prevention, protection, and control. We summarize the challenges that arise from personal protective equipment (PPE) disposal and finally give an overview of new smart textile-based products that emerged in the markets related to the control and spread reduction of SARS-CoV-2.
The Na<sup>+</sup>‐motive respiration in <i>Escherichia coli</i> (1989)

The protonophorous uncoupler carbonyl cyanide m ‐chlorophenylhydrazone was found to inhibit the growth rate of E. coli and maintenance of the membrane potential (Δψ) in intact bacterial cells. Both inhibitory effects of the protonophore were strongly decreased by Na + . A favourable action of Na + could be observed only when cells were grown under conditions of low Δµ̃H, i.e. at alkaline pH (8.6) or in the presence of the photonophore in growth medium. It was abolished by addition of ΔpH‐dissipating agents, i.e. the penetrating weak base diethylamine and the Na + /H + antiporter monensin, to the incubation medium. In inside‐out subcellular vesicles isolated from cells grown at alkaline pH, NADH oxidation was shown to be coupled to Na + uptake which was markedly stimulated by protonophore and inhibited by cyanide and HQNO. It is concluded that the growth of E. coli at alkaline pH or in the presence of protonophore gives rise to the induction of a primary respiratory Na + pump(s).
Self-assembly of block copolymers with a strongly charged and a hydrophobic block in a selective, polar solvent. Micelles and adsorbed layers (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSelf-assembly of block copolymers with a strongly charged and a hydrophobic block in a selective, polar solvent. Micelles and adsorbed layersN. Dan and M. TirrellCite this: Macromolecules 1993, 26, 16, 4310–4315Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ma00068a037https://doi.org/10.1021/ma00068a037research-articleACS PublicationsRequest reuse permissionsArticle Views690Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts