gebhart/patrepeval huggingface dataset:
Yes-associated protein 1 regulates the stability of ΔNp63α (2010)

Regulation of DeltaNp63alpha can be achieved at the transcriptional and post-translational levels, with the latter being greatly influenced by external stimuli such as DNA damaging agents. In this present study, we demonstrated that DeltaNp63alpha physical interacts with Yes-associated protein 1 (Yap1). Ectopic expression of Yap1 decreased the stability and the half-like of DeltaNp63alpha and resulted in ubiquitin-dependent degradation of DeltaNp63alpha. Further, the cisplatin mediated degradation of DeltaNp63alpha is attenuated with the downregulation of Yap1. Thus, our results strongly suggest that Yap1 plays a role in the regulation of endogenous DeltaNp63alpha levels and is likely to contribute to the regulation of DeltaNp63alpha, in physiological conditions.
Quasi-2D Surface-Potential Solution to Three-Terminal Undoped Symmetric Double-Gate Schottky-Barrier MOSFETs (2008)

This paper presents an analytical quasi-2D surface potential solution to Schottky-Barrier (SB) MOSFETs, with one unified terminal-bias and device-parameter dependent characteristic length, which takes the screening of the gate field by free carriers into account. The proposed model is also valid for arbitrary terminal bias with respective to any reference voltage and applicable to asymmetric SB-DG devices. Terminal current can be calculated based on the obtained energy band model, which can provide insights into the modeling and design of future advanced MOSFETs with Schottky-barrier source/drain contacts.
Enabling Co-Channel Small-Cell Deployments in SINR-Constraint Networks by Distributed Monitoring of Normalized Network Capacity (2013)

We propose distributed algorithms for real-time monitoring and admission control that allow base stations in heterogeneous wireless cellular networks to dynamically serve mobile users under the constraint of: 1) accommodating all active transmissions in a single shared channel; and 2) guaranteeing a minimum signal-to-interference-plus-noise ratio (SINR) to each served user. In particular, we develop distributed techniques for iterative real-time computation of the spectral radius of an unknown network matrix (often the Perron root of the matrix) that indicates the time-varying limits of power control stability, i.e., the limits of network capacity. Solely locally available information is used as algorithmic input. By drawing a formal analogy with the Google PageRank algorithm, the computations are shown analytically to be exponentially fast and sufficiently accurate for optimal (error-free) stability detection. Numerical simulations of an existing office building demonstrate the applicability of the proposed algorithms to actual UMTS W-CDMA systems characterized by discrete power control with limited step-size.
TGF-<i>beta</i> 1 and cyclic AMP promote apoptosis in resting human B lymphocytes. (1995)

TGF-beta and agents that elevate intracellular cAMP levels are potent inhibitors of B cell activation in vitro and have been shown to arrest stimulated B cells in the G1 phase of the cell cycle. We tested the effects of TGF-beta 1 and the cAMP-inducing agent, forskolin, on the viability of resting B cells from human peripheral blood, and found that both agents caused a significant, dose-dependent increase in cell death relative to spontaneous death in medium alone, as measured by vital dye staining with propidium iodide. Apoptosis was shown to be the overall mode of death by demonstrating DNA fragmentation using DNA nick end labeling and by verifying the characteristic morphologic changes. In contrast with TGF-beta 1 and forskolin, various B cell activation stimuli generally inhibited spontaneous apoptosis of resting cells. The most potent effects were observed with IL-4 and the phorbol ester, O-tetradecanoylphorbol-13-acetate (TPA), an activator of protein kinase C. IL-4 also partly inhibited TGF-beta 1 and forskolin-induced apoptosis. In contrast, TPA completely reversed cell death in forskolin-treated cultures, but had no effect on TGF-beta 1-induced apoptosis, indicating that TGF-beta 1 and forskolin promote apoptosis by different mechanisms. The relative protein expression of bcl-2, a proto-oncogene that inhibits apoptosis, was unaltered by the apoptotic as well as the survival stimuli tested, suggesting that apoptosis was regulated by a bcl-2-independent mechanism. We conclude that apoptosis is a regulated phenomenon in resting human B cells. Furthermore, TGF-beta and cAMP may inhibit B cell responses not only by blocking cell cycle progression in activated cells, but also by inducing apoptosis in resting cells.
Short-cycle structured intermittent treatment of chronic HIV infection with highly active antiretroviral therapy: Effects on virologic, immunologic, and toxicity parameters (2001)

Although continuous highly active antiretroviral therapy (HAART) is effective for many HIV-infected patients, it can be toxic and prohibitive in cost. By decreasing the total amount of time patients receive medications, intermittent HAART could reduce toxicity and cost. Therefore, we initiated a pilot study in which 10 HIV-infected individuals receiving effective therapy that resulted in levels of HIV RNA <50 copies per ml of plasma and CD4(+) T cell counts >300 cells per mm(3) of whole blood received repeated cycles of 7 days on HAART followed by 7 days off of HAART. Patients maintained suppression of plasma viremia for 32-68 weeks. There was no significant increase in HIV proviral DNA or replication-competent HIV in peripheral CD4(+) T cells or HIV RNA in peripheral blood or lymph node mononuclear cells. There was no significant change in CD4(+) T cell counts, no significant increase in CD4(+) or CD8(+) T cells expressing activation markers or producing IFN-gamma in response to HIV, no increase in CD4(+) T cell proliferation to p24 antigen, and no evidence for the development of resistance to HAART medications. There was a significant decrease in serum cholesterol and triglyceride levels. Thus, in this proof-of-concept study, short-cycle intermittent HAART maintained suppression of plasma viremia as well as HIV replication in reservoir sites while preserving CD4(+) T cell counts. In addition, there was a decrease in serum cholesterol and triglyceride levels. Intermittent therapy may be an important strategy to reduce cost and toxicity for HIV-infected individuals.
A microcontamination model for rotating disk chemical vapor deposition reactors (1998)

This paper presents preliminary results from a model currently under development for gas-phase generated submicron-size contaminant particles (i.e., microcontaminants) in rotating disk chemical vapor deposition reactors. These particles present a problem during semiconductor processing, and this model is intended as a useful tool for gaining a better understanding of this problem. A one-dimensional formulation is employed to model the central section of the reactor, a technique which allows the use of detailed chemical reaction sets. The existing Sandia SPIN code, which contains a solver for the reacting flow, is modified by the addition of an aerosol model for the particles. This model utilizes a moment transport formulation which accounts for convection, diffusion, gravity, thermophoresis, chemical production, coagulation and condensation. Results are presented primarily in terms of reactor performance maps which indicate film growth and contamination rates as functions of substrate temperature. The effects of variations in reactor operating parameters on these maps are discussed.
Microwave Spectroscopy of Seven Conformers of 1,2-PROPANEDIOL (2009)

W.Caminati, \textit{J. Mol. Spectrosc.
Motion corrected MRI with DISORDER: Distributed and Incoherent Sample\n Orders for Reconstruction Deblurring using Encoding Redundancy (2019)

Purpose: To enable rigid-body motion tolerant parallel volumetric magnetic\nresonance imaging by retrospective head motion correction on a variety of\nspatio-temporal scales and imaging sequences. Theory and methods: Tolerance\nagainst rigid-body motion is based on distributed and incoherent sampling\norders for boosting a joint retrospective motion estimation and reconstruction\nframework. Motion resilience stems from the encoding redundancy in the data, as\ngenerally provided by the coil array. Hence, it does not require external\nsensors, navigators or training data, so the methodology is readily applicable\nto sequences using 3D encodings. Results: Simulations are performed showing\nfull inter-shot corrections for usual levels of in-vivo motion, large number of\nshots, standard levels of noise and moderate acceleration factors. Feasibility\nof inter- and intra-shot corrections is shown under controlled motion in-vivo.\nPractical efficacy is illustrated by high quality results in most corrupted of\n208 volumes from a series of 26 clinical pediatric examinations collected using\nstandard protocols. Conclusion: The proposed framework addresses the rigid\nmotion problem in volumetric anatomical brain scans with sufficient encoding\nredundancy which has enabled reliable pediatric examinations without sedation.\n
Fluorinated quorum sensing inhibitors: enhancement of potency through conformational control (2021)

The bacterial quorum sensing (QS) system is a target for non-lethal antibacterial agents that do not encourage the development of resistance. QS inhibitors commonly contain a polar "head" moiety and a lipidic "tail" moiety. In this work, we synthesised novel QS inhibitor candidates in which the lipidic "tail" is decorated with stereospecifically positioned fluorine atoms. The presence of fluorine is shown to bias the molecules into distinctive conformations that are pre-organised for binding to the QS receptor. This translates into significant increases in QS inhibitory potency.
Glutathione in calf trabecular meshwork and its relation to aqueous humor outflow facility. (1983)

Previous studies have shown that sulfhydryl reagents can alter the facility of aqueous humor outflow but little is known about the sulfhydryl constituents of the aqueous outflow system or the effect of oxidants upon outflow facility. In the present study the concentration of glutathione (GSH) was measured in excised calf trabecular meshwork (TM) and found to be 0.40 mu mol/g wet wt (0.027 mu mol/mg protein). Oxidized glutathione was not detectable in the tissue. TM was found to have significant hexose monophosphate shunt activity as determined by measurement of the oxidation of 14C-1 and 14C-6-labeled glucose in tissue homogenates. The concentration of GSH in TM of enucleated calf eyes could be totally depleted by infusion of medium containing both diamide, which is an oxidant of GSH, and 1,3bis(2-chlorethyl)-1-nitrosourea (BCNU), which is an inhibitor of the enzyme glutathione reductase. The depletion of GSH was found to have no effect on the facility of aqueous outflow. Experiments were also done in which normal and TM GSH-depleted eyes were perfused with medium containing H202. Exposure to H202 produced no effect on outflow facility in the normal eyes but caused a 33% decrease in facility in eyes with the GSH-depleted TM. The results indicate that GSH may not participate directly in regulating aqueous humor outflow but is able to protect TM against H202-induced oxidative damage that would otherwise lead to a decrease in outflow facility.
Curvature-based approach for multi-scale feature extraction from 3D meshes and unstructured point clouds (2009)

A framework for extracting salient local features from 3D models is presented in this study. In the proposed method, the amount of curvature at a surface point is specified by a positive quantitative measure known as the curvedness. This value is invariant to rigid body transformation such translation and rotation. The curvedness at a surface position is calculated at multiple scales by fitting a manifold to the local neighbourhoods of different sizes. Points corresponding to local maxima and minima of curvedness are selected as suitable features and a confidence measure of each keypoint is also calculated based on the deviation of its curvedness from the neighbouring values. The advantage of this framework is its applicability to both 3D meshes and unstructured point clouds. Experimental results on a different number of models are shown to demonstrate the effectiveness and robustness of our approach.
Graded fiber waveguide with extremely low losses (1984)

The method of chemical deposition from the vapor phase was used in fabrication of a graded-index fiber-optic waveguide with losses of 2.45,0.50, and 0.25 dB/km at the wavelengths of 0.85, 1.3, and 1.55 μ, respectively, and with a bandwidth of 900 MHz-km at the wavelength of 0.87 μ. Under these conditions the excess losses were less than 0.1 dB/km.
Dilysine motifs in exon 2b of SMN protein mediate binding to the COPI vesicle protein α-COP and neurite outgrowth in a cell culture model of spinal muscular atrophy (2013)

Spinal muscular atrophy (SMA) is a devastating neuromuscular disorder that stems from low levels of survival of motor neuron (SMN) protein. The processes that cause motor neurons and muscle cells to become dysfunctional are incompletely understood. We are interested in neuromuscular homeostasis and the stresses put upon that system by loss of SMN. We recently reported that α-COP, a member of the coatomer complex of coat protein I (COPI) vesicles, is an SMN-binding partner, implicating this protein complex in normal SMN function. To investigate the functional significance of the interaction between α-COP and SMN, we constructed an inducible NSC-34 cell culture system to model the consequences of SMN depletion and find that depletion of SMN protein results in shortened neurites. Heterologous expression of human SMN, and interestingly over-expression of α-COP, restores normal neurite length and morphology. Mutagenesis of the canonical COPI dilysine motifs in exon 2b results in failure to bind to α-COP and abrogates the ability of human SMN to restore neurite outgrowth in SMN-depleted motor neuron-like NSC-34 cells. We conclude that the interaction between SMN and α-COP serves an important function in the growth and maintenance of motor neuron processes and may play a significant role in the pathogenesis of SMA.
The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review (2020)

Magnesium alloys have shown great potential for applications as both structural and biomedical materials due to their high strength-to-weight ratio and good biodegradability and biocompatibility, respectively. Among them, Mg-Zn based alloys are attracting increasing interest for both applications. As such, this article provides a review of the corrosion performance and mechanical properties of Mg-Zn based alloys, including the influence of environment and processing on both of them. The strategies for tailoring corrosion resistance and/or mechanical properties by microstructure adjustment and surface treatment are discussed.
Detection of trabeculae and papillary muscles in cardiac MR images (2005)

With the improvement of the quality of MR imagery, more and more details become visible. Only 5-10 years ago cardiac images of the heart were still so unsharp that finer details of the heart like the papillary muscles and the trabeculae were hardly visible and it was simply impossible to determine their outlines with any measure of accuracy. With the improved image quality it becomes feasible to extract information about these small structures. Studying the operation of these tiny muscles can be very useful for further analysis of the heart function and diagnosis of heart diseases. Until now very little literature existed on the study of these structures using cardiac MR, so with this publication we are riding the front of the wave. We conducted two pilot studies to investigate the feasibility of detection of papillary muscles in the left ventricular blood volume and to obtain a measure of the trabeculation of the right ventricle. The latter was also investigated as a diagnostic criterion for arrhythmogenic right ventricular dysplasia (ARVD)
An Investigation of Patient Preferences for Music Played Before Electroconvulsive Therapy (2016)

Music is a low-cost intervention with virtually no side effects that could be offered as an adjunctive therapy for patients receiving ECT. A significant proportion of patients liked hearing music before treatment.
Tracked Object Association in Multi-camera Surveillance Network (2013)

This paper proposes a multi-camera surveillance framework based on multiple view geometry. We address the problem of object association and consistent labeling through exploring geometrical correspondences of objects, not only in sequential frames from a single camera view but also across multiple camera views. The cameras are geometrically related through joint combination of multi-camera calibration, ground plane homography constraint, and field-of-view lines. Object detection is implemented using an adaptive Gaussian mixture model, and thereafter the information obtained from different cameras is fused so that the same object shown in different views can be assigned a unique label. Meanwhile, a virtual top-view of ground plane is synthesized to explicitly display the corresponding location and label of each detected object within a designated area-of-interest.
Online mercury speciation through liquid chromatography with particle beam/electron ionization mass spectrometry detection (2006)

The ability of particle beam/electron ionization-mass spectrometry (PB/EI-MS) to provide elemental and molecular information for a sample solution has been evaluated for the speciation of inorganic and organic mercury compounds. Specifically, the EI process yields mass spectra which reflect the chemical species eluting from the chromatographic column, either atomic or molecular. A detailed evaluation of source temperature and electron energy parameters has been performed for the PB/EI-MS method. Preliminary studies demonstrated that the approach can be utilized for the determination of mercury at μg mL−1 levels. A non-linear response at low concentrations (0.1–1 μg mL−1) of mercury was observed due to poor transport of small particles through the PB interface. The use of KCl as a carrier agent to enhance particle transport was investigated. The analyte responses for mercury species showed higher sensitivity with good linearity upon KCl addition, providing limits of detection on the ng mL−1 level (sub-ng absolute). The three mercury species (inorganic, phenyl- and methylmercury) were separated using a reversed phase (C18) column with a total elution time of less than 11 min and the species were detected using PB/EI-MS. Post-column addition of the KCl carrier to the mobile phase was accomplished with a HPLC pump and a tee connection. It is believed that the PB/EI-MS technique is well suited not only for speciation of mercury, but also for obtaining comprehensive speciation information via atomic and molecular mass spectral information of diverse species, and thus can be used to solve a number of speciation challenges.
SEVERAL FACTORS AFFECTING BULBLET REGENERATION FROM THE CULTURE OF SCALE SEGMENT AND NODE-BUD IN FRITILLARY AS MEDICINAL BULBOUS PLANT (1996)

ISHS International Symposium on Plant Production in Closed Ecosystems SEVERAL FACTORS AFFECTING BULBLET REGENERATION FROM THE CULTURE OF SCALE SEGMENT AND NODE-BUD IN FRITILLARY AS MEDICINAL BULBOUS PLANT
Chemically bonded phosphate ceramics for stabilizing low-level radioactive wastes (1996)

Because phosphates. are natural mineral analogs of radioactive elements, chemically bonded phosphate ceramics were developed to stabilize low-level radioactive waste. Ash, Fe{sub 2}O{sub 3}, and FePO{sub 4} wastes with 0.5 wt.% Ce{sup 3+}, added as a surrogate for U{sup 3+} and Pu{sup 3+} were stabilized in an Mg{sub 3}(PO{sub 4}){sub 2} ceramic at room temperature. The final waste forms exhibited high strength and low permeability to water. Cerium leaching from the final ash, Fe{sub 2}O{sub 3}, and FePO{sub 4} waste forms, determined by the toxicity characteristic leaching procedure, was 0.095, 0.39, and 0.49 ppb, respectively. These values are several orders of magnitude below those of Ce from untreated waste. Detailed solubility characteristics of CePO{sub 4} and microscopy of the waste form indicate that the extremely low leaching rate of Ce may be due to its chemical fixation as a monazite in the phosphate matrix, accompanied by its microencapsulation in the dense ceramic matrix of Mg{sub 3}(PO{sub 4}){sub 2} that contained very low solubility phases. These observations suggest that chemically bonded phosphate ceramics may be excellent candidate materials for stabilizing radioactive contaminants such as U and Pu.
Demonstration of Flame Detection in Room Light Background by Solar-Blind AlGaN PIN Photodiode (2001)

We have fabricated n-Al 0.44 Ga 0.56 N/i-Al 0.44 Ga 0.56 N/p-GaN heterojunction photodiodes with a cut-off wavelength of 275 nm. The multilayer device structure was grown by metal-organic vapor phase epitaxy using a low-temperature interlayer technique. Thanks to the high quality AIGaN, the responsivity dropped steeply by three, five and six orders of magnitude at the AIGaN bandedge of 275 nm, 600 nm, and 1 μm, respectively. The steep bandedge enables a minimum leakage of effective weak-flame luminescence between 250 and 280 nm. For flame detection, a visible cut-off filter to assist the selectivity to the flame luminescence was attached. In addition, the photodiode was operated at zero-bias so that the darkcurrent does not exceed the weak photocurrent induced by flame luminescence. This solar-blind photosensor thus successfully responded selectively to the flame luminescence regardless of whether the room was lighted or not.
Thin film processing and device fabrication in the Tl-Ca-Ba-Cu-O system (1991)

TlCaBaCuO films using e-beam evaporation with subsequent sintering and annealing that have critical current densities of at least several hundred kA/sq cm, critical temperatures over 100 K, and surface resistance better than that of gold at 77 K and 8 GHz. Processing techniques have been developed for making microwave passive elements and a four-terminal active device called the superconducting flux flow transistor (SFFT) for microwave applications. The techniques include contacting, dielectric, normal layer deposition, and controlled HTS film etching. The SFFT shows promise as a microwave amplifier, oscillator, and active impedance converter and may also have many other applications. The advantages of the device include high speed, potentially low noise, and, for some applications, useful impedance levels.