gebhart/patrepeval huggingface dataset:
[PP.35.28] (2015)

Objective: Many prospective trials have documented the safety and effects on the 24 h blood pressure (BP) pattern of several classes of hypertension medications are greatly improved when ingested at bedtime rather than upon awakening. Recent findings further indicate reduction of asleep BP by bedtime hypertension treatment significantly reduces the risk of cardiovascular events. We evaluated the potential differential administration-time-dependent effects on the risk of chronic kidney disease (CKD) of the various classes of hypertension medications. Design and method: We conducted a prospective, randomized, open-label, blinded endpoint trial on 2078 hypertensive patients without CKD, 1017 men/1061 women, 53.6 ± 13.7 years of age. Patients were randomized to ingest all their prescribed hypertension medications upon awakening or the entire daily dose of at least one of them at bedtime. At baseline and annually (or more frequently if hypertension treatment was adjusted based on ambulatory BP) thereafter, BP and physical activity (wrist actigraphy) were simultaneously monitored for 48 h. Results: During a 5.9-year median follow-up, 368 patients developed CKD (estimated glomerular filtration rate <60 ml/min/1.73 m2, albuminuria, or both, at least twice within 3 months). Patients in the bedtime-treatment regimen evidenced a significantly lower risk of CKD than those ingesting all medications upon awakening, independent of class. Greater benefits were observed for bedtime compared to awakening treatment with ACEIs (adjusted hazard ratio: 0.20 [95%CI: 0.10–0.38]; P < 0.001) and ARBs (0.47 [0.32–0.69], P < 0.001). There were no differences in the risk of CKD between the six classes of tested medications in patients randomized to ingest them upon awakening. Treatment at bedtime with ACEIs, however, was associated with significantly lower hazard ratio of new-onset CKD than ingestion of other classes of medications also at bedtime. Conclusions: Bedtime hypertension treatment significantly reduces the risk of developing CKD compared to conventional morning dosing independent of the class of BP-lowering medication used for treatment. There is no advantage of any particular class of medication when ingested upon awakening. Renin-angiotensin blockade, however, is significantly superior to any other BP-lowering strategy for reducing the risk of CKD when the medications are dosed at bedtime.
Contrasting Effects of Age on Muscle Contractility in Male and Female Rats (2022)

This study aimed to describe changes in forelimb grip strength and ex vivo muscle force production in adult (Ad) and aged (Ag, 75% lifespan) male (M) and female (F) F344/BN hybrid rats. We hypothesized that differences in M vs. F would be explained by muscle mass, but that age differences would persist after normalizing to mass in fast, but not slow muscles. Forelimb grip was expressed in absolute terms (Grip) and relative to body mass (NGrip). Ex vivo forces of the extensor digitorum longus (EDL) and Soleus (Sol) were assessed at 3 stimulation frequencies and 2 pulse durations, and expressed as absolute muscle force (AMF) and muscle quality (MQ; force/anatomical cross‐sectional area). We also assessed sarcoplasmic reticulum (SR) Ca2+ release and reuptake from homogenates of both muscles. Body mass was higher in Ag vs. Ad and M vs. F (both p &lt; 0.001), while EDL and Sol mass were smaller in F vs. M (p &lt; 0.001), with no effect of age. Grip showed no effect of age, but was significantly (p &lt; 0.001) lower in F while NGrip was higher in Ad vs. Ag (p &lt; 0.001) and F vs. M (p &lt; 0.001). EDL AMF exhibited a significant age X sex interaction (p = 0.006) across frequencies, as AMF declined with age in M, but increased in F. EDL MQ showed a similar pattern (p = 0.039), but only at the highest frequency (120Hz). In Sol, M showed a trend (p = 0.078) for higher AMF relative to F. In contrast, MQ was significantly higher in F vs. M (p = 0.025). Differences in SR function did not appear to contribute to these differences as the only significant effect observed was for SR Ca2+ uptake to be reduced in F vs. M in both EDL and Sol (p = 0.046 &amp; 0.050, respectively). These findings indicate that grip and isolated muscle contractility are generally higher in M vs. F when expressed in absolute terms, but lower in M vs. F when expressed as relative measures (normalized to body mass or muscle size). Minimal declines in muscle contractility occurred with age in either muscle tested, consistent with what we have observed previously with in situ testing of the Sol, but other aged fast muscles.
Palladium-catalyzed post-Ugi arylative dearomatization/Michael addition cascade towards plicamine analogues (2021)

A palladium-catalyzed intramolecular cyclization of Ugi-adducts <i>via</i> a cascade dearomatization/aza-Michael addition process has been developed. Diverse plicamine analogues are constructed in a rapid, highly efficient and step-economical manner, through the combination of an Ugi-4CR and a palladium-catalyzed dearomatization. The synthetic utility of this approach is illustrated by further functional group transformations.
P674 Potential utility of therapeutic drug monitoring of adalimumab in predicting short-term mucosal healing and histologic remission in paediatric Crohn's disease patients (2017)

Background: There is limited data regarding mucosal healing (MH) and therapeutic drug levels in paediatric Crohn's disease (CD) patients under adalimumab (ADL) treatment. We aimed to investigate the association between ADL trough levels (TLs) and MH, and between ADL TLs and histologic remission (HR) at 4 months from ADL treatment in the paediatric population of CD. Methods: This study was a preliminary analysis of an ongoing prospective cohort in paediatric CD patients receiving ADL at the Department of Pediatrics, Samsung Medical Center. Moderate-to-severe luminal CD patients who were naïve to biologics and receiving ADL before 19 years-old were included. Ileocolonoscopy and biopsies as well as clinical activity assessment, laboratory exams, including tests for ADL TLs and antibody to adalimumab (ATA) were performed at 4 months from adalimumab initiation. MH was defined as a Simple Endoscopic Score for Crohn's disease (SES-CD) of 0. Histologic remission (HR) was defined as the complete absence of microscopic inflammation on biopsy specimens obtained from sites of previous and current ulcerations. Adalimumab TLs were compared according to MH status at 4 months. Results: Table 1. Baseline characterisitics of the subjects (n=17) Continuous variables are expressed in median (range). Seventeen subjects were included in this study. At 4 months from ADL initiation, 14 (82.4%) were under clinical remission, 8 (47.1%) had achieved MH, and 4 patients (23.5%) had achieved HR. Dose intensification by interval shortening to every week was done in 1 patient (5.9%). ADL TLs were significantly higher in patients who achieved MH compared to those who did not (13.0±6.5 μg/mL vs. 6.2±2.6 μg/mL, p=0.023), and also significantly higher in patients who achieved HR compared to those who did not (17.9±5.3 μg/mL vs. 6.8±2.5 μg/mL, p=0.02). ATA was detected in 1 patient (5.9%). According to receiver operator characteristic (ROC) curve analysis, the optimal cut-point for predicting MH was 8.76 μg/mL. Figure 1. Adalimumab trough levels according to mucosal healing, histologic remission at 4 months. Figure 2. ROC curve of adalimumab trough levels in predicting mucosal healing at 4 months. Conclusions: Serum ADL TLs at 4 months were significantly higher in paediatric CD patients under MH or HR, compared to those who failed to achieve each outcome. Future relevant large-scale studies may guide in predicting short-term MH and HR in the era of treat-to-target.
Methodology to qualify silicon carbide MOSFETs for single shot avalanche events (2015)

This paper presents a methodology to establish and qualify safe bounds of operation for Silicon Carbide power devices under avalanche stress. The methodology involves using a statistical method to estimate an avalanche safe operating area, and by ensuring that device reliability is not degraded after avalanche stress. We also demonstrate the avalanche capability of the C3M 900V SiC MOSFETs, which have been fully qualified for avalanche ruggedness by employing this methodology.
Adaptive video applications for non-QoS networks (1997)

We propose an architecture which can support video services in networks which have no Quality of Services (QoS) guarantees. We demonstrate that there is a need for such services today and also in the future, when QoS will be built into most networks. We then describe our current Internet-based system, which combines both image processing and networking techniques in order to provide good quality video without harming the performance of the Internet. These techniques are shown to be superior to previous work for the environment of video services operating in the Internet.
Performance evaluation of L-PPM links using repetition rate coding (2002)

In this paper, we evaluate the performance of infrared communication methods using repetition-rate coding over L-PPM wireless links to provide reliable infrared transmission throughout indoor environments. All receivers adapt the communication data rate by monitoring the channel, and they instruct transmitters to use highest rate if it is possible. Reducing the user data rate by a factor of RR (rate reduction) results in an RR-fold SNR improvement. We analyze how repetition-rate coding improves the capture probability of the infrared modem over L-PPM links. We also discuss the effect of RR-fold transmission in utilization using go-back-N and selective reject ARQ schemes.
Cross-protective immunity of mice induced by oral immunization with pneumococcal surface adhesin A encapsulated in microspheres (2002)

The global use of a capsular polysaccharide-based pneumococcal vaccine has been limited because of serotype-specific protection and poor effectiveness in individuals with low immunocompetency. The mucosal immune system develops earlier in infants and lasts longer in the elderly than does the systemic immune system. Furthermore, mucosal immunization is beneficial for AIDS patients, because human immunodeficiency virus-infected subjects can develop normal mucosal antibody responses even in late clinical phases. For these reasons, we evaluated recombinant pneumococcal surface adhesin A (rPsaA) of Streptococcus pneumoniae in terms of cross-protective immune responses after oral delivery. Encapsulated rPsaA provided higher immunogenicity than naked rPsaA. Coencapsulation or codelivery of the cholera toxin (CT) B subunit (CTB) and CT also increased the immunogenicity of rPsaA. Cross-protective immunities against five strains of S. pneumoniae (types 4, 6B, 14, 19F, and 23F) were induced after oral immunization with microencapsulated rPsaA. Lung colonization and septicemia caused by the five serotypes were significantly inhibited by oral immunization with microencapsulated rPsaA. These results suggest that rPsaA coencapsulated with CTB can be used as an oral vaccine to induce cross-protective immunity for the prevention of pneumococcal infection.
Structural analysis of the West Hackbery No. 6 SPR storage cavern (1980)

Four separate structural analyses of the West Hackberry No. 6 SPR storage cavern are presented. One analysis covers the creep response of the cavern beginning shortly before the time when an accidental fire occurred and proceeding through the cavern recertification pressure test. The second analysis models the surface uplife that is expected during the same pressure test. The third and fourth numerical studies investigate the structural response of West Hackberry No. 6 to slabbing and a rapid pressure drop. All analyses indicate that this cavern should be structurally stable for the conditions assumed.
Homogenous nucleation rates of <i>n</i>-propanol measured in the Laminar Flow Diffusion Chamber at different total pressures (2014)

Nucleation rates of n-propanol were investigated in the Laminar Flow Diffusion Chamber. Nucleation temperatures between 270 and 300 K and rates between 10(0) and 10(6) cm(-3) s(-1) were achieved. Since earlier measurements of n-butanol and n‑pentanol suggest a dependence of nucleation rates on carrier gas pressure, similar conditions were adjusted for these measurements. The obtained data fit well to results available from literature. A small positive pressure effect was found which strengthen the assumption that this effect is attributed to the carbon chain length of the n-alcohol [D. Brus, A. P. Hyvärinen, J. Wedekind, Y. Viisanen, M. Kulmala, V. Ždímal, J. Smolík, and H. Lihavainen, J. Chem. Phys. 128, 134312 (2008)] and might be less intensive for substances in the homologous series with higher equilibrium vapor pressure. A comparison with the theoretical approach by Wedekind et al. [Phys. Rev. Lett. 101, 12 (2008)] shows that the effect goes in the same direction but that the intensity is much stronger in experiments than in theory.
Graphene oxide doped ionic liquid ultrathin composite membranes for efficient CO<sub>2</sub>capture (2016)

Thin film composite membranes were prepared using the blends of graphene oxide and an ionic liquid for efficient CO<sub>2</sub>gas capture.
Stroke Correspondence Construction Using Manifold Learning (2011)

Abstract Stroke correspondence construction is a precondition for generating inbetween frames from a set of key frames. In our case, each stroke in a key frame is a vector represented as a Disk B‐Spline Curve (DBSC) which is a flexible and compact vector format. However, it is not easy to construct correspondences between multiple DBSC strokes effectively because of the following points: (1) with the use of shape descriptors, the dimensionality of the feature space is high; (2) the number of strokes in different key frames is usually large and different from each other and (3) the length of corresponding strokes can be very different. The first point makes matching difficult. The other two points imply ‘many to many’ and ‘part to whole’ correspondences between strokes. To solve these problems, this paper presents a DBSC stroke correspondence construction approach, which introduces a manifold learning technique to the matching process. Moreover, in order to handle the mapping between unequal numbers of strokes with different lengths, a stroke reconstruction algorithm is developed to convert the ‘many to many’ and ‘part to whole’ stroke correspondences to ‘one to one’ compound stroke correspondence.
Exploration of Sleep as a Specific Risk Factor for Poor Metabolic and Mental Health: A UK Biobank Study of 84,404 Participants (2021)

Six to eight hours of sleep, as well as less fragmented sleep, predicted better long-term metabolic and mental health.
ChemInform Abstract: Enantiocomplementary Routes to 6‐Oxygenated (2Z,4E)‐Alkadiene Precursors via Diastereoselective Reduction of 2‐Cyclobuten‐1‐yl Ketones. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
High Sensitivity CPT and Pulsed CPT based Axial Magnetic Field Measurements (2018)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text G. Pati, B. Barrios, R. Depto, R. Tripathi, A. Yu, and M. Krainak, "High Sensitivity CPT and Pulsed CPT based Axial Magnetic Field Measurements," in Frontiers in Optics / Laser Science, OSA Technical Digest (Optica Publishing Group, 2018), paper FM4B.7. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
RNA‐transfected CD40‐activated B cells as a vaccine strategy in canine malignancies (2004)

Introduction: Cell‐based vaccine strategies using dendritic cells as cellular adjuvant have entered phase III trials in humans and have been found to be safe, feasible, and potentially efficacious. Canine patients are generally smaller than adult human patients, which makes production of canine dendritic cell (DC) vaccines problematic, given patient size and the small number of available DC precursors. Here we describe feasibility studies of a novel cell‐based vaccine strategy which uses CD40‐activated B‐cells (CD40‐B) loaded with RNA. This strategy is based on our observations that RNA‐transfected human CD40‐B can drive anti‐tumor T cell responses. One advantage of using CD40‐B cells is the ability to expand this cell population ex vivo, allowing for the numbers of cells required for therapeutic vaccines. Methods: Twenty milliliters of blood were drawn from 6 normal dogs and 5 canine lymphoma patients. Peripheral blood mononuclear cells were separated by Ficoll centrifugation. Culture conditions for B cell activation were optimized using CD40‐ligand, canine IL‐4, and Toll‐like receptor stimulus with CpGoligodinucleotides (ODN). Cyclosporine was added to eliminate peripheral T lymphocytes. Proliferation and activation of CD40‐B cells were demonstrated by CFSE dilution of B cells quantified by flow cytometry. Gene transfer was achieved by mRNA electroporation. Results: Marked in vitro stimulation and proliferation of canine peripheral B cells were achieved with soluble trimeric CD40L, canine IL‐4, and ODN. CD40‐B cells showed dramatic upregulation of MHC class II molecules and CD21 (B‐cell activation marker). After two weeks in culture, cells were negative for CD3 and CD4. Canine CD40‐B cells were efficiently transfected with mRNA, with &gt;60% of CD40‐B expressing green fluorescent protein after GFP mRNA electroporation. Conclusion: RNA‐transfected CD40‐B cells can be efficiently generated from normal and tumor‐bearing dogs. These results provide rationale to test tumor RNA‐transfected CD40‐B as a novel therapeutic approach to treating canine malignancies. Clinical trials in canine lymphoma have been proposed.
Sex-Related Differences in Allelic Frequency of the Human Beta T Cell Receptor SNP rs1800907: A Retrospective Analysis from Milan Metropolitan Area (2021)

This paper aims at retrospectively re-analyzing the different distribution, between males and females, in the allelic frequency of the human β T cell receptor (TCR β) single nucleotide polymorphism (SNPs) rs1800907 in Caucasian patients in the Milan metropolitan area. The allelic frequency significantly differed between sexes. Females showed higher frequency of C/C genotype than males, but lower T/C genotype (<i>p</i> < 0.0001). Heterozygous (T/C) versus homozygous (T/T + C/C) genotypes resulted in a different distribution of frequencies in males than in females, the latter possessing higher homozygosis (<i>p</i> < 0.0001). Within the limitations of this work (small number of included studies that concerned just a specific geographical area), allelic distribution according to sex might account the role of TCRβ-related SNPs in autoimmune diseases and further investigations are required to explain better this genetic background, in the perspective of a sex-related T cell immune responsiveness and auto-immunity.
Unklare Lymphadenopathie mit Panzytopenie bei einer Patientin mit rezidivierenden Hypoglykämien (2021)

Zusammenfassung Eine Patientin wurde aufgrund rezidivierender postprandialer Hypoglykämien nach Roux-en-Y-Magenbypass mit Diazoxid behandelt, nachdem eine Ernährungsumstellung keine Symptomlinderung erzielt hatte. Nach Eindosierung von Diazoxid mit guter Akutverträglichkeit wurde die Patientin entlassen. Eine Woche nach Therapieeinleitung kam es zu einer Lymphadenopathie und Panzytopenie. Es fanden sich keine Hinweise auf das Vorliegen eines Infekts. Nach Absetzen von Diazoxid sistierten die Beschwerden. Unser Fallbericht weist auf seltene unerwünschte hämatologische Arzneimittelwirkungen unter Diazoxid hin.
Die Aktivität der intrazellulären Acyl-CoA Synthetasen FATP2, FATP4 und ACSL1 bestimmt die Höhe der Fettsäureaufnahme in Hepatoma Zellen (2010)

Aims: Die Mechanismen der Fettsäureaufnahme spielen eine wichtige Rolle, um neue therapeutische Optionen für die Behandlung und Prävention der Fettleber zu finden.
4D STEM: High efficiency phase contrast imaging using a fast pixelated detector (2015)

Phase contrast imaging is widely used for imaging beam sensitive and weak phase objects in electron microscopy. In this work we demonstrate the achievement of high efficient phase contrast imaging in STEM using the pnCCD, a fast direct electron pixelated detector, which records the diffraction patterns at every probe position with a speed of 1000 to 4000 frames per second, forming a 4D STEM dataset simultaneously with the incoherent Z-contrast imaging. Ptychographic phase reconstruction has been applied and the obtained complex transmission function reveals the phase of the specimen. The results using GaN and Ti, Nd- doped BiFeO3 show that this imaging mode is especially powerful for imaging light elements in the presence of much heavier elements.
Experimental Investigations of an Icing Protection System for UAVs (2019)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;UAV icing is a severe challenge that has only recently shifted into the focus of research. Today, there are no mature icing mitigation technologies for UAVs, except for the largest fixed-wing drones. We are working on the development of an electro-thermal icing protection technology called D•ICE for medium-sized fixed-wing UAVs. As part of the design process, an experimental test campaign at the Cranfield icing wind tunnel has been conducted. This paper describes the icing protection system and shares experimental results on its capability for icing detection and anti-icing. Icing detection is based on an algorithm evaluating temperature signals that are induced on the leading-edge of the wing. A baseline signal is generated during dry (icing cloud off) conditions and compared to a signal during wet (icing cloud on) conditions. Due to significant differences in the heat transfer regime, the system can differentiate between these two states. The experiments show that our system can reliably detect icing conditions based on this principle. Furthermore, the anti-icing capability of the system is proven for two icing cases. The minimal required heat flux to keep the surface ice-free was obtained by gradually reducing power supply to the heating zones until icing could be detected. These experimental results were compared to FENSAP-ICE simulations. The test campaign includes a successful fully-autonomous run, where the system automatically detected icing and initiated suitable anti-icing measures.&lt;/div&gt;&lt;/div&gt;
Adaptive algorithms for variable-complexity video coding (2002)

Variable-complexity algorithms provide a means of managing the computational complexity of a software video CODEC. The reduction in computational complexity provided by existing variable-complexity algorithms depends on the video scene characteristics and is difficult to predict. A new approach to variable-complexity encoding is proposed. A variable-complexity DCT algorithm is adaptively updated in order to maintain a near-constant computational complexity. The adaptive update algorithm is shown to be capable of providing a significant, predictable, reduction in computational complexity with only a small loss of video quality. The proposed approach may be particularly useful for software-only video encoding, in applications where processing resources are limited.