gebhart/patrepeval huggingface dataset:
Modal Characteristics in a Single-Nanowire Cavity with a Triangular Cross Section (2008)

In this study, the modal characteristics of a single-GaN nanowire cavity with a triangular cross section surrounded by air or located on a silicon dioxide substrate have been analyzed. Two transverse resonant modes, transverse electric-like and transverse magnetic-like modes, are dominantly excited for nanowire cavities that have a small cross-sectional size of <300 nm and length of 10 microm. Using the three-dimensional finite-difference time-domain simulation method, quality factors, confinement factors, single-mode conditions, and far-field emission patterns are investigated for a nanowire cavity as a function of one length of the triangular cross section. The results of these simulations provide information that will be vital for the design and development of efficient nanowire lasers and light sources in ultracompact nanophotonic integrated circuits.
Effects of twin orientation and spacing on the mechanical properties of Cu nanowires (2017)

The role of twin orientation in mechanical behaviors of nanomaterials is drawing increasing attention. In this paper, atomistic simulations on the tensile deformation of twinned Cu nanowires (NWs) are implemented to investigate the twin orientation and spacing effects. The results of numerical simulations reveal that the tensile deformation mechanisms can be divided into three types with the twin orientation varying from 0° to 90°: dislocations slip intersecting with twin boundary (TB), stacking faults formed parallel to the TB and TB migration. Detail analysis about dislocation motion is carried out to illustrate the plastic deformation mechanisms. In addition, with the increasing of the TB spacing, there is a transition from yield with strain hardening to yield with nearly constant flow stress. The peak stress decreases with the increase of TB spacing, which can be attributed to surface roughness caused by crystal reorientation. Our findings also suggest a possible approach to tune the mechanical behaviors of low dimensional nanostructures.
Data from Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;To evaluate AZD4635, an adenosine A&lt;sub&gt;2A&lt;/sub&gt; receptor antagonist, as monotherapy or in combination with durvalumab in patients with advanced solid tumors.&lt;/p&gt;Patients and Methods:&lt;p&gt;In phase Ia (dose escalation), patients had relapsed/refractory solid tumors; in phase Ib (dose expansion), patients had checkpoint inhibitor–naïve metastatic castration-resistant prostate cancer (mCRPC) or colorectal carcinoma, non–small cell lung cancer with prior anti–PD-1/PD-L1 exposure, or other solid tumors (checkpoint-naïve or prior anti–PD-1/PD-L1 exposure). Patients received AZD4635 monotherapy (75–200 mg once daily or 125 mg twice daily) or in combination with durvalumab (AZD4635 75 or 100 mg once daily). The primary objective was safety; secondary objectives included antitumor activity and pharmacokinetics; exploratory objectives included evaluation of an adenosine gene signature in patients with mCRPC.&lt;/p&gt;Results:&lt;p&gt;As of September 8, 2020, 250 patients were treated (AZD4635, &lt;i&gt;n&lt;/i&gt; = 161; AZD4635+durvalumab, &lt;i&gt;n&lt;/i&gt; = 89). In phase Ia, DLTs were observed with monotherapy (125 mg twice daily; &lt;i&gt;n&lt;/i&gt; = 2) and with combination treatment (75 mg; &lt;i&gt;n&lt;/i&gt; = 1) in patients receiving nanosuspension. The most common treatment-related adverse events included nausea, fatigue, vomiting, decreased appetite, dizziness, and diarrhea. The RP2D of the AZD4635 capsule formulation was 75 mg once daily, as monotherapy or in combination with durvalumab. The pharmacokinetic profile was dose-proportional, and exposure was adequate to cover target with 100 mg nanosuspension or 75 mg capsule once daily. In patients with mCRPC receiving monotherapy or combination treatment, tumor responses (2/39 and 6/37, respectively) and prostate-specific antigen responses (3/60 and 10/45, respectively) were observed. High versus low blood-based adenosine signature was associated with median progression-free survival of 21 weeks versus 8.7 weeks.&lt;/p&gt;Conclusions:&lt;p&gt;AZD4635 monotherapy or combination therapy was well tolerated. Objective responses support additional phase II combination studies in patients with mCRPC.&lt;/p&gt;&lt;/div&gt;
Manipulate Vibration Propagation by Anisotropic Honeycomb Structure (2018)

As a new type of acoustic metamaterial, the pentamode material has extensive application prospect in controlling acoustic wave propagation because of its fluid properties. Firstly, a kind of pentamode material unit cell is designed, which is a two-dimensional honeycomb truss structure. Then, the asymptotic homogenization method is used to calculate static parameters of the unit cell, and also the influence of the geometric parameters and material composition of the unit cell on its mechanical properties is studied. Besides, based on transformation acoustics and the design method of the cylindrical cloak proposed by Norris, an acoustic cloak with isotropic density and gradient elastic modulus is constructed by periodically assembling the unit cell to guide the wave to bypass obstacles. Finally, the full displacement field analysis is carried out to prove the stealth effect of the acoustic cloak.
S-parameters characterization and sequence model of three-phase EMI filter (2013)

This paper investigates the characterization of three-phase EMI filter using S-parameters and the use of sequence model to fully describe the high frequency behavior. Characterization of three-phase EMI filter helps to understand the influence of real filter on overall EMI performance and provides information for filter selection or design. The characterization is divided into two types: component level or system level, which can be chosen to use according to design conditions. S-parameters are chosen as network parameters to characterize because of the convenience to measure them in high frequency range. Beside circuitry model of filter, sequence model of filter is proposed to better describe the attenuation and conversion between different forms of noise, which improves the understanding towards filter behavior compared to traditional separation of common and differential mode noise. Corresponding equations are provided to obtain parameters in the sequence model. At the end, the predictions of insertion loss and energy transfer ratio which represent the grade of mode conversion based on sequence model are shown and compared with results from conventional measurement method.
Molecular characterization of poly(3-hexylthiophene) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular characterization of poly(3-hexylthiophene)Glenn W. Heffner and Dale S. PearsonCite this: Macromolecules 1991, 24, 23, 6295–6299Publication Date (Print):November 1, 1991Publication History Published online1 May 2002Published inissue 1 November 1991https://pubs.acs.org/doi/10.1021/ma00023a035https://doi.org/10.1021/ma00023a035research-articleACS PublicationsRequest reuse permissionsArticle Views2606Altmetric-Citations150LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Soft Tactile Contour Following for Robot-Assisted Wiping and Bathing (2022)

The automated cleaning of surfaces such as furniture, bathroom sinks, and even human bodies is challenging due to the three-dimensional nature of their geometries. Yet, enabling robots to effectively and safely perform these tasks would not only reduce user efforts spent on household cleaning chores, but would also alleviate the strenuous workload of caretakers as the elderly population continues to grow at an unprecedented rate. In this work, we unify the applications of wiping objects and bathing humans as a general contour-following problem. To this end, we utilize a depth camera-based soft tactile sensor to extract the contact geometries and force-correlated measures during interaction between the robot and the target object or body part, and design a general contour-following controller that not only maintains contact with the target throughout the cleaning process, but also regulates the amount of force applied. Our system enables successful cleaning of pipes, shelving, and even human limbs and torsos without the need for data-driven methods such as deep learning, upon which the majority of existing works have relied.
Unidirectional signal propagation in primary neurons micropatterned at a single-cell resolution (2016)

The structure and connectivity of cultured neuronal networks can be controlled by using micropatterned surfaces. Here, we demonstrate that the direction of signal propagation can be precisely controlled at a single-cell resolution by growing primary neurons on micropatterns. To achieve this, we first examined the process by which axons develop and how synapses form in micropatterned primary neurons using immunocytochemistry. By aligning asymmetric micropatterns with a marginal gap, it was possible to pattern primary neurons with a directed polarization axis at the single-cell level. We then examined how synapses develop on micropatterned hippocampal neurons. Three types of micropatterns with different numbers of short paths for dendrite growth were compared. A normal development in synapse density was observed when micropatterns with three or more short paths were used. Finally, we performed double patch clamp recordings on micropatterned neurons to confirm that these synapses are indeed functional, and that the neuronal signal is transmitted unidirectionally in the intended orientation. This work provides a practical guideline for patterning single neurons to design functional neuronal networks <i>in vitro</i> with the direction of signal propagation being controlled.
Mechanisms of mixing in single and co‐rotating twin screw extruders (1995)

Abstract Previous experimental studies have revealed that the mixing efficiencies of widely used continuous processors such as the single and twin screw extruders depend on the types of screw elements, which are utilized. It is generally recognized that the basic single screw extruder and the fully‐fighted sections of the fully‐intermeshing co‐rotating twin screw extruders are not efficient mixers, in contrast to the specialized mixing elements such as the kneading discs used in co‐rotating twin screw extruders. However, no simulation techniques were available to characterize quantitatively and rigorously the mixing efficiencies of continuous processors. In this study, we have solved the three‐dimensional equations of conservation of mass and momentum, and utilized various tools of dynamics to analyze the mixing occurring in single and co‐rotating twin screw extruders. It is shown that simulation methods can indeed capture the relative differences in the mixing mechanisms of continuous processors like the single and twin screw extruders. The ability to distinguish quantitatively between the distributive mixing capabilities of various continuous processors should facilitate numerical testing of new continuous mixer designs, optimization of operating conditions and geometries of existing mixers and the material‐specific design of new mixers.
Phytochemical and biological investigations on potentially antimicrobial and anticancer Guinean plant species (2019)

Cancer and microbial infections are global public health problems, and therapeutic management remains a challenge, especially in developing countries. In Guinea, medicinal plants are still widely used for the management of these diseases. The purpose of this study was to deepen the phytochemical knowledge and investigate the therapeutical potential of selected plants, through the purification of secondary metabolites, and the evaluation of their antimicrobial and anticancer activity.
Real-time bump map synthesis (2001)

In this paper we present a method that automatically synthesizes bump maps at arbitrary levels of detail in real-time. The only input data we require is a normal density function; the bump map is generated according to that function. It is also used to shade the generated bump map.
Distillation: The Theory (2015)

Distillation based on Mass Transfer Processes, starting from the basic equation of ternary distillation published by Hausen in 1932 and exploiting the properties of this equation covering all modes of distillation. The material is intended as a graduate textbook for an advanced course on distillation but will also help the practicing engineer to better understand the complex interrelationships of multi-component distillation
Linear Cascade GaN-Based Green Light-Emitting Diodes With Invariant High-Speed/Power Performance Under High-Temperature Operation (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We demonstrate the performance of linear cascade green light-emitting diode (LED) arrays suited for use in plastic optical fiber (POF) communications in automobiles or harsh environments. With this three-LED array, driven by the constant voltage bias of an in-car battery output (12 V) we obtain high-speed (<formula formulatype="inline"><tex Notation="TeX">$\sim$</tex></formula>100-Mb/s eye-opening), high-coupling power (0.9 mW), and a very small variation of coupled power versus temperature [<formula formulatype="inline"><tex Notation="TeX">$-$</tex> </formula>0.12%<formula formulatype="inline"><tex Notation="TeX">$^{\circ}\hbox{C}^{-1}$</tex> </formula> at room temperature (RT)] for the whole measured temperature range (i.e., RT to 120 <formula formulatype="inline"><tex Notation="TeX">$^{\circ}$</tex> </formula>C). Even under high bias current (100 mA) operation, our device can sustain a clear 150-Mb/s eye-opening from RT to 120 <formula formulatype="inline"> <tex Notation="TeX">$^{\circ}$</tex></formula>C. The static and dynamic measurement results indicate that the speed and power performance of this device are less sensitive to variations in ambient temperature than are those of the red resonant-cavity LEDs utilized for POF communication. </para>
Polypyrrole-coated Membrane Filter: A Novel Binder-free Three- Dimensional Porous Electrode for Supercapacitors (2014)

In this paper, polypyrrole was prepared using the vapor phase polymerization process on membrane filter. The resulting membrane filter is flexible with electrical conductivity of 6.7 S/cm. When used as a binder-free threedimensional porous electrode for supercapacitor, such membrane filter delivers high specific capacitances of 310 and 130 F/g at current densities of 1 and 5 A/g, respectively, with excellent cycling stability.
1308 Results of Sound Detection Feasibility Test of In-vehicle Warning System for Drivers (2012)

To reveal a possibility of detecting the direction of the sound such as in-vehicle warning, authors conducted the indoor test using 15 young and 15 elderly subjects. Speaker positions were selected in six ways (three in the front, three back), sound pressure levels were set three types and five combinations of sound frequencies were adopted. On the results of experiment, we could reveal the difference of easiness of detecting the warning direction according to speaker positions and other factors.
Synthesis and Biological Evaluation of ABCD Ring Fragments of the Kibdelones (2011)

Arylierungen jetzt auch mit Platin: Die Synthese des Titelsystems gelang durch eine neuartige PtIV-katalysierte Arylierung eines Chinonmonoketals und anschließende Photocyclisierung (siehe Schema). Nach ersten biologischen Tests an Krebszelllinien sind die verkürzten Kibdelon-Analoga rund 2000-mal weniger aktiv als die Kibdelone B und C, was darauf hinweist, dass die Tetrahydroxanthonstruktur der Kibdelone entscheidend für die Zytotoxizität ist. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Is active glucose transport present in bovine ciliary body epithelium? (2006)

Hyperglycemia is a major risk factor for diabetic cataract formation. Effective regulation of glucose transport by the ciliary body epithelium (CBE) is pivotal to normal glycemic control in the anterior eye, which in turn affects the glucose level of the crystalline lens. The present study aimed to characterize the glucose transport mechanisms across the bovine blood-aqueous barrier (BAB) represented by the CBE. With an Ussing-type chamber, the glucose transport kinetics were measured and characterized in the presence and absence of various glucose transporter inhibitors. The saturation characteristics of the CBE to glucose were estimated from an Eadie-Hofstee plot. The mRNA expression of glucose transporters in specific regions of the bovine CBE was assessed using RT-PCR. The trans-CBE glucose flux was found to be sensitive to the glucose transporter inhibitors cytochalasin B, phloretin, and phlorizin. The transport system had a kinetic constant of 5.3 mM and a maximum velocity of 349.5 nmol.h(-1).cm(-2). Gene expression for GLUT1, GLUT3, GLUT4, GLUT5, and SGLT2 was observed in both the pars plana and pars plicata regions of the bovine CBE. This study demonstrates that glucose transport across the bovine CBE is primarily passive in nature. However, the novel findings of 1) the presence of a phlorizin-sensitive glucose flux and 2) gene expression for SGLT2 mean that a potential role for active glucose transport cannot be ruled out. The elucidation of the exact function of SGLT2 in the bovine CBE may shed important light on the glucose transport and physiology of the BAB and inform future studies of glycemic control in relation to diabetic cataract formation.
Design Rules for Additive Manufacturing of Titanium Cellular Structures by Electron Beam Melting (2013)

International audience
Evaluation of two power assist systems for manual wheelchairs for usability, performance and mobility: a pilot study (2021)

Further studies are required to understand the usability, performance, and mobility of power-assist devices. Moving forward, these findings will inform end users and occupational therapists when procuring manual wheelchair power-assist devices.Implications for rehabilitationPower-assist devices (PADs) for manual wheelchairs increase the potential for community participation.Qualitative findings showed a general preference for using the Batec® for long trips outside and for off-road terrains, primarily due to the Batec's® perceived better speed control, maximum speed, and simpler braking system.The SmartDrive® + Freewheel® was deemed most useful indoors and in tight spaces; due to a smaller wheelchair footprint, better turning radius, and increased device portability.Increasing knowledge and research about PADs will support development of alternative options for manual or power wheelchairs users. PADs may allow manual wheelchair users (MWC) to delay moving to a power wheelchair (PWC), potentially reducing the perceived stigma associated with transitioning to a power wheelchair and impacting health outcomes.
Using Mise-En-Scène Visual Features based on MPEG-7 and Deep Learning for Movie Recommendation (2017)

Item features play an important role in movie recommender systems, where recommendations can be generated by using explicit or implicit preferences of users on traditional features (attributes) such as tag, genre, and cast. Typically, movie features are human-generated, either editorially (e.g., genre and cast) or by leveraging the wisdom of the crowd (e.g., tag), and as such, they are prone to noise and are expensive to collect. Moreover, these features are often rare or absent for new items, making it difficult or even impossible to provide good quality recommendations. In this paper, we show that user's preferences on movies can be better described in terms of the mise-en-scène features, i.e., the visual aspects of a movie that characterize design, aesthetics and style (e.g., colors, textures). We use both MPEG-7 visual descriptors and Deep Learning hidden layers as example of mise-en-scène features that can visually describe movies. Interestingly, mise-en-scène features can be computed automatically from video files or even from trailers, offering more flexibility in handling new items, avoiding the need for costly and error-prone human-based tagging, and providing good scalability. We have conducted a set of experiments on a large catalogue of 4K movies. Results show that recommendations based on mise-en-scène features consistently provide the best performance with respect to richer sets of more traditional features, such as genre and tag.
Inframe deletion of human <i>ESPN</i> is associated with deafness, vestibulopathy and vision impairment (2018)

Our study uncovers an additional USH gene, assigns the USH1 phenotype to a variant of <i>ESPN</i> and provides a 12th molecular component to the USH proteome.
Solid‐state reactivity and mechanisms in oxide systems (IV) on the sintering behaviour of haematite (1988)

Abstract The present contribution reports about the sintering behaviour of three α‐Fe 2 O 3 powders which were synthesized in various ways. The different results of the sintering experiments are the consequence of granulometric properties of the samples and of their content of impurities. Possible sintering mechanisms are discussed.
Excess mortality associated with increased pulse pressure among middle-aged men and women is explained by high systolic blood pressure (2000)

Increasing pulse pressure is a predictor of death from coronary heart disease, stroke, cardiovascular disease and all causes in men and women aged 45-64 years, but the increase in risk is entirely associated with the increase in systolic blood pressure.