gebhart/patrepeval huggingface dataset:
Differential <i>In Vitro</i> Immortalization Capacity of Eleven, Probable High-Risk Human Papillomavirus Types (2013)

Epidemiological studies identified 12 high-risk HPV (hrHPV) types and 8 probable/possible hrHPV types that display different cancer risks. Functional studies on transforming properties of hrHPV are mainly limited to HPV16 and -18, which induce immortalization of human foreskin keratinocytes (HFKs) by successive bypass of two proliferative life span barriers, senescence and crisis. Here, we systematically compared the in vitro immortalization capacities, as well as influences on p53, pRb, hTERT, growth behavior, and differentiation capacity, of nine hrHPV types (HPV16, -18, -31, -33, -35, -45, -51, -52, and -59), and two probable hrHPV types (HPV66 and -70). By retroviral transduction, the respective E6/E7 coding sequences were expressed in HFKs from two or three independent donors. Reduced p53 levels and low-level hTERT expression in early-passage cells, as seen in HPV16-, -31-, -33-, and -35-, and to a lesser extent HPV18-transduced HFKs, was associated with continuous growth and an increased immortalization capacity. Less frequent immortalization by HPV45 and -51 and immortalization by HPV66 and -70 was preceded by an intervening period of strongly reduced growth (crisis) without prior increase in hTERT expression. Immortalization by HPV59 was also preceded by a period crisis, despite the onset of low hTERT expression at early passage. HPV52 triggered an extended life span but failed to induce immortality. Variations in p53 and pRb levels were not correlated with differences in alternative E6/E7 mRNA splicing in all hrHPV-transduced HFKs. On collagen rafts, transductants showed disturbed differentiation reminiscent of precancerous lesions. In conclusion, in vitro oncogenic capacities differ between the established hrHPV types, and both some established and probable hrHPV types display weak or moderate immortalization potential.
SEGMENTIERUNG, VOLUMENBESTIMMUNG UND VISUALISIERUNG MEDIZINISCHER DATEN VERSCHIEDENER MODALITÄTEN (2000)

Article SEGMENTIERUNG, VOLUMENBESTIMMUNG UND VISUALISIERUNG MEDIZINISCHER DATEN VERSCHIEDENER MODALITÄTEN was published on January 1, 2000 in the journal Biomedical Engineering / Biomedizinische Technik (volume 45, issue s1).
ChiraleC2-symmetrische CuII-Komplexe als Katalysatoren für enantioselektive Hetero-Diels-Alder-Reaktionen (1998)

Luftstabil und wiederverwendbar ist der CuII-Bis(oxazolin)-Komplex 1, der enantio- und diastereoselektive Hetero-Diels-Alder-Reaktionen von β,γ-ungesättigten α-Oxosäure-Derivaten 2 mit Vinylethern zu substituierten Dihydropyranen 3 effizient katalysiert [Gl. (1)]. Die Kristallstruktur von 1 in Verbindung mit Modellrechnungen legt nahe, daß durch Austausch der beiden H2O-Liganden gegen das chelatisierende Substrat ein reaktives Intermediat entsteht. X=OEt, N(OMe)Me; R=Alkyl, Aryl, Alkoxy, Thiobenzyl.
Comparisons Of An Adaptive Neural Network Based Controller And An Optimized Conventional Power System Stabilizer (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Alteration of Plasma Membrane Organization by an Anticancer Lysophosphatidylcholine Analogue Induces Intracellular Acidification and Internalization of Plasma Membrane Transporters in Yeast (2013)

The anti-tumor lipid edelfosine alters lipid raft integrity. How this signals inhibition of growth is not understood. Results: Disruption of plasma membrane domain organization triggers the selective removal of lipid raft-associated transporters altering pH homeostasis. Conclusion: Raft integrity controls pH homeostasis and growth. Significance: Choline-containing lysolipid analogues induce biophysical modifications of microdomains leading to inhibition of cell growth through alteration of pH homeostasis.
Mono vs. Difunctional Coumarin as Photoinitiators in Photocomposite Synthesis and 3D Printing (2020)

This work is devoted to investigate three coumarin derivatives (Coum1, Coum2, and Coum3), proposed as new photoinitiators of polymerization when combined with an additive, i.e., an iodonium salt, and used for the free radical polymerization (FRP) of acrylate monomers under mild irradiation conditions. The different coumarin derivatives can also be employed in three component photoinitiating systems with a Iod/amine (ethyl 4-dimethylaminobenzoate (EDB) or N-phenylglycine (NPG)) couple for FRP upon irradiation with an LED @ 405 nm. These compounds showed excellent photoinitiating abilities, and high polymerization rates and final conversions (FC) were obtained. The originality of this work relies on the comparison of the photoinitiating abilities of monofunctional (Coum1 and Coum2) vs. difunctional (Coum3) compounds. Coum3 is a combined structure of Coum1 and Coum2, leading to a sterically hindered chemical structure with a relatively high molecular weight. As a general rule, a high molecular weight should reduce the migration of initiating molecules and favor photochemical properties such as photobleaching of the final polymer. As attempted, from the efficiency point of view, Coum3 can initiate the FRP, but a low reactivity was observed compared to the monofunctional compound (Coum1 and Coum2). Indeed, to study the photochemical and photophysical properties of these compounds, different parameters were taken into account, e.g., the light absorption and emission properties, steady state photolysis, and fluorescence quenching. To examine these different points, several techniques were used including UV-visible spectroscopy, real-time Fourier Transform Infrared Spectroscopy (RT-FTIR), fluorescence spectroscopy, and cyclic voltammetry. The photochemical mechanism involved in the polymerization process is also detailed. The best coumarins investigated in this work were used for laser writing (3D printing) experiments and also for photocomposite synthesis containing glass fibers.
ChemInform Abstract: Neighboring Group Participation in Lewis Acid‐Promoted (3 + 4) and (3 + 5) Annulations. The Stereocontrolled Synthesis of Tricyclic Ethers. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Multimeric Anti-DR5 IgM Agonist Antibody IGM-8444 Is a Potent Inducer of Cancer Cell Apoptosis and Synergizes with Chemotherapy and BCL-2 Inhibitor ABT-199 (2021)

Death receptor 5 (DR5) is an attractive target for cancer therapy due to its broad upregulated expression in multiple cancers and ability to directly induce apoptosis. Though anti-DR5 IgG antibodies have been evaluated in clinical trials, limited efficacy has been attributed to insufficient receptor crosslinking. IGM-8444 is an engineered, multivalent agonistic IgM antibody with 10 binding sites to DR5 that induces cancer cell apoptosis through efficient DR5 multimerization. IGM-8444 bound to DR5 with high avidity and was substantially more potent than an IgG with the same binding domains. IGM-8444 induced cytotoxicity in a broad panel of solid and hematologic cancer cell lines but did not kill primary human hepatocytes <i>in vitro</i>, a potential toxicity of DR5 agonists. In multiple xenograft tumor models, IGM-8444 monotherapy inhibited tumor growth, with strong and sustained tumor regression observed in a gastric PDX model. When combined with chemotherapy or the BCL-2 inhibitor ABT-199, IGM-8444 exhibited synergistic <i>in vitro</i> tumor cytotoxicity and enhanced <i>in vivo</i> efficacy, without augmenting <i>in vitro</i> hepatotoxicity. These results support the clinical development of IGM-8444 in solid and hematologic malignancies as a monotherapy and in combination with chemotherapy or BCL-2 inhibition.
VEGF and BMP Expression in Mouse Osteosarcoma Cells (2006)

Osteosarcoma is the most common primary bone malignancy. Despite improvements in therapy, approximately 30% of patients experience pulmonary metastasis. Expression of several growth factors, including VEGF and BMPs, has been implicated in tumor progression and metastatic potential. We hypothesized increased metastatic potential of mouse osteosarcoma cells positively correlates with the expression of VEGF and BMPs. We studied the expression patterns of these growth factors in two murine osteosarcoma cell lines with varying degrees of metastatic potential: K7M2 (highly metastatic) and K12 (minimally metastatic). Expression of VEGF and BMP2 were higher in the metastatic K7M2 cell line. We also investigated the effects of the BMP antagonist noggin on osteosarcoma growth characteristics in vitro. We noted decreased motility, altered morphology, and increased cell death in the highly metastatic K7M2 cell line. Less metastatic K12 cells showed substantial cell death without clear alteration of motility or morphology. These data suggest BMP2 expression may be an important factor in osteosarcoma metastasis and noggin administration theoretically could block its actions. Inhibition of BMPs and VEGF should be investigated further as a possible strategy for decreasing the incidence of pulmonary metastases in osteosarcoma.
The impact of moisture ingress on encapsulated carbon based Perovskite cells (2021)

Session Perovskites - 2
Reduced Environmental Redox Potential Affects Both Transcription and Expression of the Pap Pili Gene (1992)

Pyelonephritis-associated pili (pap) gene expression is subject to a phase variation control mechanism by which cells alternate between two pili-expression states, viz. a 'phase-off (pili - ) and a 'phase-on' (pili + ) state. During interaction with a host, Escherichia coli encounter various environmental redox conditions. We have addressed the question of whether bacteria are able to respond to this environmental signal by regulating pap pili biogenesis, a crucial colonisation factor in pyelonephritis. Transcription from the PapB promoter (papBAp) was studied in the Salmonella typhimurium papBAp lac fusion lysogen strain under aerobic, microaerobic and anaerobic conditions. In this strain, the  β-galactosidase gene is under the control of the papB promoter that initiates transcription of both the papB gene encoding the regulatory papB protein and the papA gene encoding the structural pilin protein. The frequency of switching rrom the Lac + (papBAp 'on') to the Lac - . (papBAp 'off) state was about 1-3-fold higher when the environmental redox potential was reduced by changing from aerobic to microaerobic and anaerobic growth milieus. The β-galactosidase activity representing the rate of transcriptional initiation from the papB promoter was, as calculated pcr 10 8 Lac + bacteria, more than 12-fold higher in acrobically cultivated bacteria than in bacteria cultured undcr microaerobic or anaerobic conditions. Pap pili adhesin expression was measured under the same redox conditions, using E. coli K12 HB101 pPap 5 containing a plasmid coding for whole pap pili operon. The strongest pap pili expression, measured as agglutination of latex gal-gal beads, was observed under microaerobic conditions similar to those found in the urinary tract. Under anaerobic conditions like those prevalent in the intestine, pap pili expression was negligible. This is not surprising, since such expression would not represent an ecological advantage for E. coli. In fact, repression of these types of fimbriae under anaerobic conditions may be a way in which the bacteria can save energy which can then be used to promote growth. Although the two genetic models used for transcription and expression studies are distinct, a high rate of transcription did not seem to correlate with optimal pili expression. This may indicate the importance of the post-transcriptional processing in pap pili expression. Keywords: Pilus gene regulation; Growth conditions; Aerobic; Anaerobic; Microaerobic; Adhesion.
Rolling Texture of α"-Phase in Ti-22mol%Nb-3mol%Al Biomedical Shape Memory Alloy (2007)

Rolling texture of α"(C-orthorhombic) martensite phase in Ti-22mol%Nb-3mol%Al β-titanium based shape memory alloy was examined using X-ray pole figure measurement. The alloy was dual phase of α'' and β(bcc) at room temperature (RT) and was cold-rolled with reduction rates of 40%~99% at RT. Stress-induced martensitic transformation occurred during the rolling and then the material was fully transformed into martensite phase. Subscript α" and β indicate martensite and parent phase hereafter. The major texture was close to {411}α"&lt;173&gt;α" when the reduction rate was lower than 60%. This texture is a result of a preferential formation of specific variants which have a higher interaction with the macroscopic deformation. As the reduction rate was increased, ND moved toward {101}α" whereas RD was around &lt;010&gt;α" regardless of the reduction rate. {101}α"&lt;010&gt;α" texture was confirmed when the reduction rate was 99%.
Temperature Evolution of Magnon Propagation Length in Tm$_3$Fe$_5$O$_{12}$ Thin Films: Roles of Magnetic Anisotropy and Gilbert Damping (2023)

The magnon propagation length ($\langleξ\rangle$) of a ferro/ferrimagnet (FM) is one of the key factors that controls the generation and propagation of thermally-driven spin current in FM/heavy metal (HM) bilayer based spincaloritronic devices. Theory predicts that for the FM layer, $\langleξ\rangle$ is inversely proportional to the Gilbert damping ($α$) and the square root of the effective magnetic anisotropy constant ($K_{\rm eff}$). However, direct experimental evidence of this relationship is lacking. To experimentally confirm this prediction, we employ a combination of longitudinal spin Seebeck effect (LSSE), transverse susceptibility, and ferromagnetic resonance experiments to investigate the temperature evolution of $\langleξ\rangle$ and establish its correlation with the effective magnetic anisotropy field, $H_K^{\rm eff}$ ($\propto K_{\rm eff}$) and $α$ in Tm$_3$Fe$_5$O$_{12}$ (TmIG)/Pt bilayers. We observe concurrent drops in the LSSE voltage and $\langleξ\rangle$ below 200$^\circ$K in TmIG/Pt bilayers regardless of TmIG film thickness and substrate choice and attribute it to the noticeable increases in $H_K^{\rm eff}$ and $α$ that occur within the same temperature range. From the TmIG thickness dependence of the LSSE voltage, we determined the temperature dependence of $\langleξ\rangle$ and highlighted its correlation with the temperature-dependent $H_K^{\rm eff}$ and $α$ in TmIG/Pt bilayers, which will be beneficial for the development of rare-earth iron garnet-based efficient spincaloritronic nanodevices.
Using fold recognition to search for useful proteins: Bayesian approach to fold recognition (2002)

The wealth of protein sequence and structure data is greater than ever, thanks to the ongoing Genomics and Structural Genomics projects. The information available through such efforts needs to be analysed by new methods that combine both databases. One important result of genomic sequence analysis is the inference of functional homology among proteins. Until recently sequence similarity comparison was the only method for homologue inference. The new fold recognition approach reviewed in this paper enhances sequence comparison methods by including structural information in the process of protein comparison. This additional information often allows for the detection of similarities that cannot be found by methods that only use sequence information.
Glyphosate Effect on Shikimate, Nitrate Reductase Activity, Yield, and Seed Composition in Corn (2010)

When glyphosate is applied to glyphosate-resistant (GR) crops, drift to nonglyphosate-resistant (non-GR) crops may cause significant injury and reduce yields. Tools are needed to quantify injury and predict crop losses. In this study, glyphosate drift was simulated by direct application at 12.5% of the recommended label rate to non-GR corn (Zea mays L.) at 3 or 6 weeks after planting (WAP) during two field seasons in the Mississippi delta region of the southeastern USA. Visual plant injury, shikimate accumulation, nitrate reductase activity, leaf nitrogen, yield, and seed composition were evaluated. Effects were also evaluated in GR corn and GR corn with stacked glufosinate-resistant gene at the recommended label rate at 3 and 6 WAP. Glyphosate at 105 g ae/ha was applied once at 3 or 6 weeks after planting to non-GR corn. Glyphosate at 840 (lower label limit) or 1260 (upper label limit) g ae/ha was applied twice at 3 and 6 WAP to transgenic corn. Glyphosate caused injury (45-55%) and increased shikimate levels (24-86%) in non-GR compared to nontreated corn. In non-GR corn, glyphosate drift did not affect starch content but increased seed protein 8-21% while reducing leaf nitrogen reductase activity 46-64%, leaf nitrogen 7-16%, grain yield 49-54%, and seed oil 18-23%. In GR and GR stacked with glufosinate-resistant corn, glyphosate applied at label rates did not affect corn yield, leaf and seed nitrogen, or seed composition (protein, oil, and starch content). Yet, nitrate reductase activity was reduced 5-19% with glyphosate at 840 + 840 g/ha rate and 8-42% with glyphosate at 1260 + 1260 g/ha rate in both GR and GR stacked corn. These results demonstrate the potential for severe yield loss in non-GR corn exposed to glyphosate drift.
AR-V7 Key in Tx of mCRPC (2018)

In this video, Dr. Andrew Armstrong explains why AR-V7–positive men rarely benefit from abiraterone or enzalutamide, and advises on AR-V7 testing as a clinical tool.
Induction of <i>WT1</i> (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression (2004)

The Wilms' tumor gene WT1 is overexpressed in leukemias and various types of solid tumors, and the WT1 protein was demonstrated to be an attractive target antigen for immunotherapy against these malignancies. Here, we report the outcome of a phase I clinical study of WT1 peptide-based immunotherapy for patients with breast or lung cancer, myelodysplastic syndrome, or acute myeloid leukemia. Patients were intradermally injected with an HLA-A*2402-restricted, natural, or modified 9-mer WT1 peptide emulsified with Montanide ISA51 adjuvant at 0.3, 1.0, or 3.0 mg per body at 2-week intervals, with toxicity and clinical and immunological responses as the principal endpoints. Twenty-six patients received one or more WT1 vaccinations, and 18 of the 26 patients completed WT1 vaccination protocol with three or more injections of WT1 peptides. Toxicity consisted only of local erythema at the WT1 vaccine injection sites in patients with breast or lung cancer or acute myeloid leukemia with adequate normal hematopoiesis, whereas severe leukocytopenia occurred in patients with myelodysplastic syndrome with abnormal hematopoiesis derived from WT1-expressing, transformed hematopoietic stem cells. Twelve of the 20 patients for whom the efficacy of WT1 vaccination could be assessed showed clinical responses such as reduction in leukemic blast cells or tumor sizes and/or tumor markers. A clear correlation was observed between an increase in the frequencies of WT1-specific cytotoxic T lymphocytes after WT1 vaccination and clinical responses. It was therefore demonstrated that WT1 vaccination could induce WT1-specific cytotoxic T lymphocytes and result in cancer regression without damage to normal tissues.
Transmission capacity scaling of SDMA in wireless ad hoc networks (2009)

We consider an uncoordinated ad hoc network in which each multi-antenna transmitter sends multiple independent streams to different receivers in a Poisson field of interferers. We provide exact and approximate outage probability expressions and transmission capacity scaling laws, aiming at investigating the fundamental limits of space division multiple access (SDMA). We first show that superlinear capacity scaling with the number of receive/transmit antennas can be achieved using dirty paper precoding. Nevertheless, the potential benefits of multi-stream and multi-antenna communications fall off quickly if linear precoding is employed, leading even to sublinear capacity growth for single-antenna receivers. Our results indicate that receive antenna array processing is of prime importance in SDMA ad hoc networks, as a means to cancel the increased residual interference and boost the signal power through diversity.
Momentum dependence of the superconducting gap and in-gap states in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:msub><mml:mi mathvariant="normal">MgB</mml:mi><mml:mn>2</mml:mn></mml:msub></mml:math>multiband superconductor (2015)

We use tunable laser-based angle-resolved photoemission spectroscopy to study the electronic structure of the multiband superconductor ${\mathrm{MgB}}_{2}$. These results form the baseline for detailed studies of superconductivity in multiband systems. We find that the magnitude of the superconducting gap on both $\ensuremath{\sigma}$ bands follows a BCS-like variation with temperature with ${\mathrm{\ensuremath{\Delta}}}_{0}\ensuremath{\sim}7\phantom{\rule{0.28em}{0ex}}\mathrm{meV}$. The value of the gap is isotropic within experimental uncertainty and in agreement with a pure $s$-wave pairing symmetry. We also observe in-gap states confined to ${k}_{F}$ of the $\ensuremath{\sigma}$ band that occur at some locations of the sample surface. The energy of this excitation, $\ensuremath{\sim}3$ meV, is somewhat larger than the previously reported gap on $\ensuremath{\pi}$ Fermi sheet and therefore we cannot exclude the possibility of interband scattering as its origin.
Optical and Electrical Properties of Phase Change Materials for High-Speed Optoelectronics (2019)

By doping Ge 2 Sb 2 Te 5 phase change material with tungsten, we produce material with improved electrical properties while simultaneously maintaining the optical contrast necessary for light modulation and switching. © 2019 The Author(s)
Generalized model of giant-dipole-resonance splitting (2004)

A simple semimicroscopic model that makes it possible to take into account the deformation, configuration, and isospin splitting of a giant dipole resonance is formulated and is used to describe the gross structure of the photoabsorption cross section in spherical, deformed, and transition nuclei over the mass range 10 ≲ A ≲ 240.
Application of HTS wire and cables to power transmission: state of the art and opportunities (2002)

Conductors based on silver sheathed (BiPb)/sub 2/Sr/sub 2/Ca/sub 2/Cu/sub 3/O/sub x/, (BSCCO-2223) are enabling commercialization of high temperature superconducting (HTS) wires. HTS power transmission cables are now being deployed in field demonstrations worldwide. Warm dielectric (WD) and cold dielectric coaxial (CDC) cable designs offer opportunities for compact high power cables in applications that cannot be served by conventional copper cables. Utilities and cable manufacturers are recognizing the potential of this technology and are responding with demonstration installations. By 2003, six major demonstrations are scheduled to be in operation (or completed) in five countries.
Development of an unit type robot "KOHGA2" with stuck avoidance ability (2007)

To search victims in the narrow space at the disaster site, we have developed the snake-like rescue robot called "KOHGA". The robot is constructed by connecting multiple crawler vehicles serially by active joints. KOHGA has a problem that obstacles are caught to the joints and then the robot is stuck. To solve this problem, we developed an unit assembled robot "KOHGA2". It can be rearranged. The robot can swing crawler-arms and avoid the stuck. In this paper, we report the construction of the hardware and the control system of KOHGA2, the basic mobility performance, and the stuck avoidance strategy.