gebhart/patrepeval huggingface dataset:
Protein phosphatase-1 inhibitor-2 promotes PP1γ positive regulation of synaptic transmission (2022)

Inhibitor-2 (I-2) is a prototypic inhibitor of protein phosphatase-1 (PP1), a major serine-threonine phosphatase that regulates synaptic plasticity and learning and memory. Although I-2 is a potent inhibitor of PP1 <i>in vitro</i>, our previous work has elucidated that, <i>in vivo</i>, I-2 may act as a positive regulator of PP1. Here we show that I-2 and PP1<i>γ</i>, but not PP1α, positively regulate synaptic transmission in hippocampal neurons. Moreover, we demonstrated that I-2 enhanced PP1<i>γ</i> interaction with its major synaptic scaffold, neurabin, by Förster resonance energy transfer (FRET)/Fluorescence lifetime imaging microscopy (FLIM) studies, while having a limited effect on PP1 auto-inhibitory phosphorylation. Furthermore, our study indicates that the effect of I-2 on PP1 activity <i>in vivo</i> is dictated by I-2 threonine-72 phosphorylation. Our work thus demonstrates a molecular mechanism by which I-2 positively regulates PP1 function in synaptic transmission.
Neuroevolution in Games: State of the Art and Open Challenges (2015)

This paper surveys research on applying neuroevolution (NE) to games. In neuroevolution, artificial neural networks are trained through evolutionary algorithms, taking inspiration from the way biological brains evolved. We analyze the application of NE in games along five different axes, which are the role NE is chosen to play in a game, the different types of neural networks used, the way these networks are evolved, how the fitness is determined and what type of input the network receives. The paper also highlights important open research challenges in the field.
Parathyrsoidins A–D, Four New Sesquiterpenoids from the Soft Coral Paralemnalia thyrsoides (2013)

Four new nardosinane-type sesquiterpenoids, parathyrsoidins A-D (1-4) were isolated from the soft coral Paralemnalia thyrsoides. The structures of parathyrsoidins A-D (1-4) were determined by extensive spectral analysis and their cytotoxicity against selected cancer cell lines as well as antiviral activity against human cytomegalovirus (HCMV) were evaluated in vitro.
Prognostic Value of Perioperative Near-Infrared Spectroscopy During Neonatal and Infant Congenital Heart Surgery for Adverse In-Hospital Clinical Events (2012)

At bypass conclusion, 10 minutes of MUF does not adversely affect cerebral or renal NIRS. Left and right cerebral NIRS are equal, so that biparietal cerebral NIRS monitoring is probably not warranted. Perioperative cerebral and renal NIRS readings, respectively, below 45% and 40% correlate with ECMO/death and renal NIRS below 30% with prolonged ICU stay. Cerebral NIRS and lactate levels showed a strong inverse correlation during the first six postoperative hours.
Functionally Graded Ti-Ni Shape Memory Alloys (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
POSTTRANSPLANTATION PLASMACYTIC PROLIFERATION RELATED TO KAPOSI'S SARCOMA-ASSOCIATED HERPESVIRUS (1998)

30 Kaposi's sarcoma-associated herpesvirus (KSHV), implicated in the pathogenesis of Kaposi's sarcoma, has also been associated with body cavity based primary effusion lymphoma and some cases of multicentric Castleman's disease (CD). KSHV vIL-6 is expressed in hematopoietic cells infected by KSHV and may functionally mimic human IL-6, a cytokine which inhibits apoptosis of B cells. We describe two solid organ transplant recipients who developed KS and, subsequently, unusual lymphoproliferative syndromes associated with KSHV infection which clinically mimicked EBV related post-transplant lymphoproliferative disease (PTLPD). The first patient developed recurrent pleural effusions and CD-like changes in lymph nodes, which contained marked interfollicular infiltrates of plasma cells. The second patient developed progressive, systemic lymphadenopathy and hepatosplenomegaly secondary to massive infiltration by polyclonal plasma cells and mature plasmacytoid B cells. The first patient's effusions resolved following interferon therapy. Despite a reduction in immunosuppression, the second patient developed multisystem failure and died of an acute hemorrhage precipitated by ongoing coagulopathy. At autopsy, there was infiltration of multiple organs, lymph node groups, and the CNS by plasma cells and plasmacytold cells. In both cases, KSHV vIL-6 expression was demonstrated in cells from affected sites by immunohistochemical localization (IHC), and KSHV DNA was demonstrated in the tissues by PCR and Southern blot. No evidence of monocionality was detected in any of the proliferations from either patient by Southern blot hybridization using probes to the immunoglobulin heavy chain gene and EBV terminal repeat region. By IHC, the plasma cells were polyclonal, with normal κ:λ ratios. By contrast, 31 biopsy samples from 19 patients with EBV related PTLPDs examined for evidence of KSHV co-infection and/or vIL-6 expression did not show evidence of an association. The cases comprised a wide spectrum of B cell lineage proliferations including infectious mono-like (IM) (N=6), plasma cell hyperplasia (N=3), polymorphous B cell lymphoma (N=14), and monomorphic B cell lymphoma (N=3) as well as 5 EBV associated peripheral T cell lymphomas. No KSHV vIL-6 expression by IHC was found in any of these 31 specimens. KSHV DNA was not detected by PCR in 27 of the 31 samples tested. All cases except the 5 IM-like lesions showed evidence of monoclonality, either by immunoglobulin gene rearrangement or EBV terminal repeat analysis. We believe the recurrent effusions (case 1) and plasma cell infiltration in these two patients may be related to molecular mimicry of human IL-6 by KSHV encoded protein, vIL-6. By morphologic, immunophenotypic, and molecular criteria, the infiltrates in these two patients were not representative of malignancy in either patient, and the clinical course of the two patients was not typical of EBV related PTLPD. KSHV infection should be considered in the differential diagnosis of PTLPD.
Structural Analysis of a Periplasmic Binding Protein in the Tripartite ATP-independent Transporter Family Reveals a Tetrameric Assembly That May Have a Role in Ligand Transport (2008)

Several bacterial solute transport mechanisms involve members of the periplasmic binding protein (PBP) superfamily that bind and deliver ligand to integral membrane transport proteins in the ATP-binding cassette, tripartite tricarboxylate transporter, or tripartite ATP-independent (TRAP) families. PBPs involved in ATP-binding cassette transport systems have been well characterized, but only a few PBPs involved in TRAP transport have been studied. We have measured the thermal stability, determined the oligomerization state by small angle x-ray scattering, and solved the x-ray crystal structure to 1.9 A resolution of a TRAP-PBP (open reading frame tm0322) from the hyperthermophilic bacterium Thermotoga maritima (TM0322). The overall fold of TM0322 is similar to other TRAP transport related PBPs, although the structural similarity of backbone atoms (2.5-3.1 A root mean square deviation) is unusually low for PBPs within the same group. Individual monomers within the tetrameric asymmetric unit of TM0322 exhibit high root mean square deviation (0.9 A) to each other as a consequence of conformational heterogeneity in their binding pockets. The gel filtration elution profile and the small angle x-ray scattering analysis indicate that TM0322 assembles as dimers in solution that in turn assemble into a dimer of dimers in the crystallographic asymmetric unit. Tetramerization has been previously observed in another TRAP-PBP (the Rhodobacter sphaeroides alpha-keto acid-binding protein) where quaternary structure formation is postulated to be an important requisite for the transmembrane transport process.
Erster nichtkovalent gebundener Calix[4]aren-GdIII-Albumin-Komplex (2000)

Der Gadolinium(III)-Komplex des neuen wasserlöslichen Calix[4]arentetraamids 1 ist das erste Calix[4]aren, das nichtkovalent an menschliches Serumalbumin (HSA) bindet, wie durch kernmagnetische Relaxationsdispersionsexperimente nachgewiesen wurde. Er eignet sich damit prinzipiell als Kontrastmittel für NMR-Bildgebungsverfahren.
Telomerase activity and expression of its RNA component in cervical lesions (1998)

BACKGROUND The authors investigated telomerase enzyme activity and expression of its RNA component (hTR) during the multistage pathogenesis of cervical carcinomas, and correlated activation with histopathologic findings and human papillomavirus (HPV) infection. METHODS The authors analyzed 180 cervical specimens for enzyme activity, and analyzed hTR expression in an additional 55 samples from archival carcinoma cases. Polymerase chain reaction-based assays were used to determine telomerase enzyme activity and HPV infection, whereas a radioactive in situ assay was used for hTR expression. RESULTS Telomerase enzyme activity was present in some samples of histologically normal epithelium (18 of 138; 13%) and low grade squamous intraepithelial lesions (LSIL) (7 of 21; 33%), and in most high grade squamous intraepithelial lesions (HSIL) (13 of 21; 62%). The relative levels of telomerase activity were low in all preinvasive specimens except for three samples of HSIL with high activity. Although 21% of the brush samples had evidence of HPV infection, there was no obvious correlation between telomerase activity and HPV status. hTR expression was low in normal squamous/glandular epithelium and LSIL lesions, in which it was limited to the basal cells. In squamous and glandular in situ and invasive carcinomas, increased and dysregulated hTR expression was observed, although heterogeneity was noted. Intense focal up-regulation of hTR expression occurred in a subset of in situ lesions. CONCLUSIONS Increased frequency and dysregulation of telomerase activation is correlated with increasing severity of histopathologic changes, but not with HPV infection. Whether dysregulated activity is a prognostic marker for development of invasive carcinoma remains to be determined. Cancer 1998;82:1319-27. © 1998 American Cancer Society.
The orbital effect on the anomalous magnetism and evolution in La$_x$Y$_{1-x}$VO$_3$($0\le x \le 0.2$) single crystals (2021)

The orbital effect on the anomalous magnetism and evolution of low La-doping single crystals, La$_x$Y$_{1-x}$VO$_{3}$ (x = 0, 0.1, and 0.2), has been investigated by applying the X-ray diffraction, specific heat, magnetization and Raman scattering techniques. The larger nearest-neighbor (NN) exchange interaction along c-axis stabilizes the fluctuant G-type orbital ordering (G-OO) which favors the exotic C-type antiferromagnetic order (C-AF). It is found that the NN exchange interaction in ab plane is anisotropy relating to the in plane magnetic anisotropy, which becomes smaller in high La-doped sample. Most interestingly, with increasing the La$^{3+}$ content the orbital fluctuation and hybridization are decreased which stabilizes the C-OO phase and destabilizes the G-OO phase. Meanwhile, the diamagnetism in the exotic C-AF phase becomes weak and the possible mechanism relates to the change of the competition between the single-ion magnetic anisotropy and the Dzyaloshinsky-Moriya (DM) interaction with increasing x. Finally, the strong spin-orbital coupling has been observed at temperature just above T$_N$ in La$_{0.2}$Y$_{0.8}$VO$_{3}$ and a short range spin-orbital correlation is suggested.
Outpatient treatment of low-risk venous thromboembolism with monotherapy oral anticoagulation: patient quality of life outcomes and clinician acceptance (2016)

Hestia-negative VTE patients treated with oral monotherapy at home had low rates of VTE recurrence and bleeding, as well as quality of life measurements similar to prior reports.
Degraded effectiveness studies for major developmental systems and high-density items. Final report (1985)

The Army Materiel System Analysis Activity was tasked by the Army Nuclear and Chemical Agency to evaluate the survivability/sustainability of major US Army developmental systems in a NBC environment. Three areas were of interest: decontaminability, hardness, and compatibility. The Vulnerability Lethality Division of the Ballistic Research Laboratory was asked to evaluate compatibility of fourteen systems with operators in chemical protective clothing. This clothing, referred to as Mission Oriented Protective Posture (MOPP) may be worn to provide various levels of protection. The most protective, level IV, requires all equipment to be worn and sealed. The physiological abilities of personnel functioning in this equipment are encumbered by the restriction of the MOPP gear. Restriction manifested by a decrease in the accuracy of completing a task or a combination of changes in both rate and accuracy. For the purpose of this study, degradation is defined as the difference between the time to accomplish a task in Battle Dress Uniform and accomplishing the same task in MOPPIV. This task was divided in two parts: first, determine 12 hour mission profiles and second, calculate degraded effectiveness.
A comparison of vapour pressure measurements of quinizarin and <i>leuco</i>‐quinizarin via transpiration and thermogravimetry (2003)

The vapour pressure of solids can be obtained using a number of methods, including the Knudsen effusion method, the Knudsen torque‐effusion method and a transpiration method. Each method has benefits and disadvantages. Reported is a comparison of vapour pressure data for two compounds, quinizarin and leuco ‐quinizarin, using a transpiration method and a recently developed method based on thermogravimetry. Thermogravimetry provided vapour pressure–temperature dependence data for each compound with expediency and in agreement with the transpiration method.
Pulse-pumped operation of divalent transition-metal lasers (1982)

The pulse-pumped operating characteristics of liquid-nitrogen-cooled Ni:MgF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , Co:MgF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> , and Ni:CaY <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Mg <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> Ge <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> O <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</inf> (CAMGAR) solid-state lasers have been studied. The internal quantum efficiency of the Ni:MgF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> laser was found to be limited to approximately 40 percent, presumably because of excited-state absorption. The Co:MgF <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> laser operated with near-unity quantum efficiency, and generated 150 mJ of diffraction-limited output at repetition rates up to 50 Hz. A continuous tuning range from 1.6 to 2.3 μm was observed along with <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</tex> -switched peak output powers of 80 kW. Laser operation from the garnet-structured crystal Ni:CAMGAR was obtained at a wavelength of 1.46 μm.
A mediator for statistical linked data (2013)

This paper introduces a mediation architecture to help describing and consuming statistical data, exposed as RDF triples, but stored in relational databases. The architecture features a catalogue of linked data cube descriptions, created according to the Linked Data principles. The catalogue has a standardized description for each data cube actually stored in each statistical (relational) database known to the mediation environment. The mediator offers an interface to browse the linked data cube descriptions and exports the data cubes as RDF triples, generated on demand from the underlying databases.
ChemInform Abstract: Synthesis and Lithium Intercalation Properties of Nanocrystalline Lithium Iron Oxides. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Why is Partial-breast Irradiation Still Investigational (2012)

The investigational nature of partial breast irradiation (PBI) remains an area of controversy in the field of breast radiotherapy. While we have a long track record of conducting and strongly supporting the research in this area, we have chosen the more cautious approach of continuing to offer PBI only as part of a trial, open to selected breast cancer patients at low risk of local recurrence. This position reflects the fact that existing whole breast radiotherapy has revealed very successful in controlling local recurrences and it remains the safest choice for the patient. Our thinking has been reinforced by the recent data linking the prevention of recurrence to long term breast cancer survival: until more is known about PBI safety, its indiscriminate use may deprive some women from their best chance of fighting breast cancer. Considerations regarding the correct interpretation of the available evidence in view of the still limited duration of follow up and of the pattern of local recurrence of breast cancer sustain our position that PBI can be offered only in the context of a clinical trial. Unfortunately, more time and data are warranted for PBI to be legitimately recognized a standard radiotherapy approach in breast conservation therapy.
The neurohormone orexin stimulates hypoxia-inducible factor-1 activity (2007)

Orexin A and Orexin B (also known as hypocretins) are neuropeptides that bind two related G-coupled protein receptors (OXR1 and OXR2) and thus induce wakefulness, food consumption, and locomotion. Conversely, deletion of the orexin gene in mice produces a condition similar to canine and human narcolepsy. Despite the central importance of the orexin system in regulating wakefulness and feeding behavior, little is known about the downstream signaling mechanisms that achieve these effects. In this study, genomics techniques are used to probe this question and reveal that orexin activates the hypoxia-inducible factor 1 (HIF-1), a heterodimeric transcription factor whose pathogenic role in stimulating angiogenesis in hypoxic tumors has been the focus of intense investigation. Orexin-stimulated HIF-1 activity is due to both increased HIF-1alpha gene transcription and a down-regulation of von Hippel-Lindau (VHL), the E3 ubiquitin ligase that mediates the turnover of HIF-1 via the ubiquitin-proteasome pathway. Orexin-mediated activation of HIF-1 results in increased glucose uptake and higher glycolytic activity, as expected from studies of hypoxic cells. However, orexin receptor-expressing cells somehow override the HIF-1-mediated preference for funneling pyruvate into anaerobic glycolysis and instead favor ATP production through the tricarboxylic acid cycle and oxidative phosphorylation. These findings implicate HIF-1 as an important transcription factor in the hormone-mediated regulation of hunger and wakefulness.
Climate change and human survival (2014)

The IPCC report shows the need for “radical and transformative change”

Next week the Intergovernmental Panel on Climate Change (IPCC) will publish its report on the impacts of global warming. Building on its recent update of the physical science of global warming,1 the IPCC’s new report should leave the world in no doubt about the scale and immediacy of the threat to human survival, health, and wellbeing.

The IPCC has already concluded that it is “virtually certain that human influence has warmed the global climate system” and that it is “extremely likely that more than half of the observed increase in global average surface temperature from 1951 to 2010” is anthropogenic.1 Its new report outlines the future threats of further global warming: increased scarcity of food and fresh water; extreme weather events; rise in sea level; loss of biodiversity; areas becoming uninhabitable; and mass human migration, conflict and violence. Leaked drafts talk of hundreds of millions displaced in a little over 80 years. This month, the American Association for the Advancement of Science (AAAS) added its voice: “the well being of people of all nations [is] at risk.”2 Such comments reaffirm the conclusions of …
Alumina ceramic foams as catalyst supports (2016)

Ceramic foams have a wide range of potential applications in biomedicine, thermal insulation, filtration of molten metal alloys, adsorption of environmental pollutants, catalyst supports, etc. Since the physical properties of the foams do not fully meet the requirements in some applications, improvement of conventional fabrication methods or totally new techniques are of interest. Herein, three main methods of manufacturing ceramic foams are introduced with the main emphasize on the replica technique. Furthermore, different techniques for improving structural properties of ceramic foams are reviewed. The focus of this review is on fabrication of macro-porous alumina foams with high interconnected porosity. In addition, experimental data for manufacturing of ceramic foams via the replica technique are presented along with literature surveys. Slurries consisted of alumina powder mixed in aqueous solutions of polyvinyl alcohol (PVA) and magnesia and titania as sintering aids. The foams were produced by tuning different processing parameters to give properties suited for catalyst supports. These parameters included pore size of the polyurethane (PU) foam used as a template, parameters in the PU foam pretreatment, particle size of alumina powder in the slurry, slurry loading and drying of the green alumina coated PU foam. Finally, the key factors for optimizing ceramic foams in terms of mechanical strength and interconnectivity are introduced together with an outlook for future advances in ceramic foams as catalyst supports.
ABO blood group and SARS‐CoV‐2 antibody response in a convalescent donor population (2021)

Eligible CCP donors with blood group B may have relatively higher neutralizing antibody titres. Additional studies evaluating ABO blood groups and antibody titres that incorporate COVID-19 severity are needed.