gebhart/patrepeval huggingface dataset:
DeltaFS: a scalable no-ground-truth filesystem for massively-parallel computing (2021)

High-Performance Computing (HPC) is known for its use of massive concurrency. But it can be challenging for a parallel filesystem's control plane to utilize cores when every client process must globally synchronize and serialize its metadata mutations with those of other clients. We present DeltaFS, a new paradigm for distributed filesystem metadata. DeltaFS allows jobs to self-commit their namespace changes to logs, avoiding the cost of global synchronization. Followup jobs selectively merge logs produced by previous jobs as needed, a principle we term No Ground Truth which allows for efficient data sharing. By avoiding unnecessary synchronization of metadata operations, DeltaFS improves metadata operation throughput up to 98X leveraging parallelism on the nodes where job processes run. This speedup grows as job size increases. DeltaFS enables efficient inter-job communication, reducing overall workflow runtime by significantly improving client metadata operation latency up to 49X and resource usage up to 52X.
La calidad docente a partir de la evaluación 360º. Una experiencia en el Grado de Comunicación Audiovisual (Universidad de Barcelona) (2014)

espanolEste trabajo presenta los resultados de la experiencia de evaluacion de la calidad docente a traves de un proceso multifuente 360o en la asignatura Proyectos (Grado en Comunicacion Audiovisual). Durante el curso 2011-2012 se implanto por primera vez, y tras ser calificados los alumnos, se evaluo la accion docente a partir de indicadores blandos (percepciones de los responsables academicos, estudiantes y docentes implicados) y duros (recursos tecnicos y humanos disponibles, resultados academicos y tasa de abandono). Responsables academicos y estudiantes coinciden a la hora de considerar que los principales aprendizajes adquiridos son los vinculados a ―saber hacer‖ y ―saber ser‖. Ademas, enfatizan las dificultades que conlleva el trabajo grupal colaborativo. Profesorado y responsables docentes perciben falta de coordinacion en la gestion docente, y lo atribuyen a la falta de criterios comunes sobre el producto audiovisual a desarrollar. Por ultimo, se obtuvieron resultados academicos y tasa de abandono satisfactorios, aunque los recursos disponibles eran escasos. Los resultados obtenidos han de facilitar las guias de intervencion que promuevan la adquisicion de las competencias por parte de los estudiantes, redundando en los niveles de implicacion, satisfaccion y compromiso con la asignatura por parte de profesores, estudiantes, y gestores academicos. EnglishThis paper presents the results of a 360o multisource quality evaluation experience in the subject Projects (Audiovisual Communication). The subject was introduced for the first time during the academic year 2011-2012, and after students qualification, the teaching action was evaluated with soft indicators (academic managers, students and teachers perceptions) and hard indicators (available technical and human resources, academic performance and dropout rate). Academic managers and students agreed to consider that the learned topics were linked to know-how and know how to be. They also emphasized the difficulties of collaborative work. Teachers and academic managers perceived uncoordinated management and they attributed it to the lack of common criteria to develop the audiovisual product. Finally, the academic results and dropout rate were satisfactory although available resources were low. The results have to provide intervention guidelines to promote the acquisition of skills that result in higher levels of involvement, satisfaction and commitment by teachers, students, academic managers and employers.
Evaluating Computer Intrusion Detection Systems (2015)

The evaluation of computer intrusion detection systems (which we refer to as intrusion detection systems) is an active research area. In this article, we survey and systematize common practices in the area of evaluation of such systems. For this purpose, we define a design space structured into three parts: workload, metrics, and measurement methodology. We then provide an overview of the common practices in evaluation of intrusion detection systems by surveying evaluation approaches and methods related to each part of the design space. Finally, we discuss open issues and challenges focusing on evaluation methodologies for novel intrusion detection systems.
Dual emissive analogue of deoxyuridine as a sensitive hydration-reporting probe for discriminating mismatched from matched DNA and DNA/DNA from DNA/RNA duplexes (2015)

Herein, we report the incorporation in DNA of a tailored dual emissive probe with exquisite sensitivity to hydration.
Comment on Electrochemical Kinetics at Ordered Graphite Electrodes (2012)

ADVERTISEMENT RETURN TO ISSUEPREVCommentNEXTComment on Electrochemical Kinetics at Ordered Graphite ElectrodesRichard L. McCreery* and Mark T. McDermottView Author Information Department of Chemistry, National Institute for Nanotechnology, University of Alberta, Edmonton, Alberta, Canada T6G 2A1*Tel.: 780-641-1760. E-mail: [email protected]Cite this: Anal. Chem. 2012, 84, 5, 2602–2605Publication Date (Web):January 24, 2012Publication History Published online10 February 2012Published inissue 6 March 2012https://pubs.acs.org/doi/10.1021/ac2031578https://doi.org/10.1021/ac2031578article-commentaryACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views3056Altmetric-Citations125LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (3 MB) Get e-AlertscloseSUBJECTS:Charge transfer,Defects,Electrodes,Redox reactions,Two dimensional materials Get e-Alerts
Sol‐Gel Processing of Batio3 for Electro‐Optic Waveguide Devices (2006)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusions
Viscoelastic capillary flow: the case of whole blood (2016)

The dynamics of spontaneous capillary flow of Newtonian fluids is well-known and can be predicted by the Lucas-Washburn-Rideal (LWR) law. However a wide variety of viscoelastic fluids such as alginate, xanthan and blood, does not exhibit the same Newtonian behavior.<br />In this work we consider the Herschel-Bulkley (HB) rheological model and Navier-Stokes equation to derive a generic expression that predicts the capillary flow of non-Newtonian fluids. The Herschel-Bulkley rheological model encompasses a wide variety of fluids, including the Power-law fluids (also called Ostwald fluids), the Bingham fluids and the Newtonian fluids. It will be shown that the proposed equation reduces to the Lucas-Washburn-Rideal law for Newtonian fluids and to the Weissenberg-Rabinowitsch-Mooney (WRM) law for power-law fluids. Although HB model cannot reduce to Casson’s law, which is often used to model whole blood rheology, HB model can fit the whole blood rheology with the same accuracy.<br />Our generalized expression for the capillary flow of non-Newtonian fluid was used to accurately fit capillary flow of whole blood. The capillary filling of a cylindrical microchannel by whole blood was monitored. The blood first exhibited a Newtonian behavior, then after 7 cm low shear stress and rouleaux formation made LWR fails to fit the data: the blood could not be considered as Newtonian anymore. This non-Newtonian behavior was successfully fit by the proposed equation.
Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics (2019)

Autosomal dominant polycystic kidney disease (ADPKD) is an inherited malady affecting 12.5 million people worldwide. Therapeutic options to treat PKD are limited, due in part to lack of precise knowledge of underlying pathological mechanisms. Mimics of the second mitochondria-derived activator of caspases (Smac) have exhibited activity as antineoplastic agents and reported recently to ameliorate cysts in a murine ADPKD model, possibly by differentially targeting cystic cells and sparing the surrounding tissue. A first-in-kind <i>Drosophila</i> PKD model has now been employed to probe further the activity of novel Smac mimics. Substantial reduction of cystic defects was observed in the Malpighian (renal) tubules of treated flies, underscoring mechanistic conservation of the cystic pathways and potential for efficient testing of drug prototypes in this PKD model. Moreover, the observed differential rescue of the anterior and posterior tubules overall, and within their physiologically diverse intermediate and terminal regions implied a nuanced response in distinct tubular regions contingent upon the structure of the Smac mimic. Knowledge gained from studying Smac mimics reveals the capacity for the <i>Drosophila</i> model to precisely probe PKD pharmacology highlighting the value for such critical evaluation of factors implicated in renal function and pathology.
Optimal Working Points of a Singlet-Triplet S-T Qubit (2014)

We propose an optimal set of quantum gates for a singlet-triplet qubit in a double quantum dot with two electrons utilizing the S-T− subspace. Qubit rotations are driven by the applied magnetic field and an orthogonal field gradient provided by a micromagnet. We optimize the fidelity of this qubit as a function of magnetic fields, taking advantage of “sweet spots” where the rotation frequencies are independent of the energy level detuning, providing protection against charge noise. We simulate gate operations and qubit rotations in the presence of quasistatic noise from charge and nuclear spins as well as leakage to nonqubit states, and predict that in silicon quantum dots gate fidelities greater than 99% can be achieved for two nearly-orthogonal rotation axes.
4J-3 A New Rheological Model Based on Fractional Derivatives for Biological Tissues (2006)

The intuitive use of viscoelastic properties is routinely done by physicians via the palpation. However, such an examination relies on the physician experience and is not quantitative nor reproducible. Thus, elastography has been developed to complement the palpation by reliable and reproducible measurements. The principle of elastography is to image elastic waves propagation in a medium. To evaluate the shear moduli, Helmholtz transforms are applied to the displacement images. Then the waves movie is interpreted using a rheological model. For instance, the Voigt model explains the observed frequency dependence of the measured shear wave speed. It has been shown to be a reliable model for mimicking tissue phantoms such as gelatin based phantoms. However, we show here that neither this model nor the Maxwell model are applicable to biological tissues using in vivo data (breast) and ex vivo data (liver). Although these simple models are widely used in the elastography community, they have been substituted by more relevant models in the micro-rheology community in order to reveal the solid-liquid duality of tissues. Based on these experimental observations, we introduce a new rheological model relying on fractional derivatives closer to the viscoelastic properties of in vivo data. Indeed, we observed that the dynamic modulus (Gd) and the loss modulus (Gl) have the same frequency behavior: a non-integer frequency power law smaller than 1. This frequency behavior is contradictory with the use of the Voigt model or any kind of simple arrangements of dash pots and springs. In order to explain this frequency behavior the concept of spring pot was introduced. Moreover, we observed that the ratio Gl /Gd is constant and not linked to the non-integer power observed, not predicted by the spring pot model. Thus we build a network of spring pots where the basic element is responsible of the frequency power and the network is responsible of the ratio Gl/Gd . The experiments were conducted on fresh liver samples and phantoms between 50 Hz and 100 Hz. The frequency behavior was analyzed by plotting the real and imaginary parts of the complex shear modulus using MR-elastography as well as 3D ultrasound based elastography. By applying the fractional derivatives model to these data sets, we observed that the frequency power law in the liver was equal to 0.75 (a liquid-like behavior), while the ratio parameter of the network was equal to 0.15 (a solid-like behavior). The dispersion curves of Gd and Gl obtained through this model correlates much better with the experimental observations. The model parameters values seem to emphasize the necessity to take into account the solid-liquid duality of tissues in the rheological model choice for elastography reconstructions
Brain transcriptomes and plasma proteins reveal upregulation of a proinflammatory signature in <i>APOE</i> e4 carriers (2020)

Abstract Background APOE e4 —the main genetic risk factor for Alzheimer’s disease (AD)—is associated with an increased Aβ plaque burden. Aβ plaques are surrounded by activated microglia, but whether APOE influences microglial responses to plaques in human brains has not yet been extensively studied. In this study, we investigated whether APOE alleles are associated with differences in microglial gene expression—either in concert with, or independent of, AD neuropathological changes—and with plasma protein levels. Method We analyzed brain transcriptomics data from the Mount Sinai Brain Bank (MSBB) and the Rush Religious Orders Study and Memory and Aging Project (ROSMAP). We performed integrative analysis to evaluate microglia gene expression across all APOE alleles: e4+ (e3/e4, e4/e4), e2+ (e2/e2, e2/e3) and e3/e3 (reference), adjusting for Braak neurofibrillary tangle (NFT) stage and CERAD neuritic plaque (NP) score. Additionally, we investigated the effect of the e4 allele on the plasma levels of 400 proteins in 34 cognitively normal subjects, measured using the Olink TM Proximity Extension Assay (PEA) panels. Result More than a third of the microglial genes were significantly upregulated in e4+ individuals controlling for CERAD NP score. Sensitivity analysis using Braak NFT stage yielded similar results. These genes included complement factors ( C3 , PLAU , PLAUR ), Toll‐like receptor ( TLR2 , TLR5 , TLR7 , SPP1 ), and chemokines ( CCL2 , CCR5 , CCR10 ). Of note, ∼20% of these genes were significantly increased even in cognitively normal e4+ subjects with low AD neuropathological changes at autopsy (none or sparse NP and Braak NFT stage 0‐II), suggesting e4 is associated with an enhanced baseline inflammatory pattern. A similar pro‐inflammatory profile was also observed in the plasma of cognitively normal e4+ carriers. Conclusion Our brain transcriptomic analyses and multiplexed quantification of plasma proteins indicate that carrying the APOE e4 allele is associated with a pro‐inflammatory program compared to the APOE e3/e3 reference group. This differential effect of the APOE e4 allele was observed in brains of individuals with low AD neuropathological changes at autopsy, suggesting that it is not just mediated through its effects on amyloid plaques. Thus, APOE e4 may prime microglia toward a pro‐inflammatory phenotype before plaques and tangles develop.
Environmental Enteropathy in Undernourished Pakistani Children: Clinical and Histomorphometric Analyses (2018)

Despite nutrition interventions, stunting thought to be secondary to underlying environmental enteropathy (EE) remains pervasive among infants residing in resource-poor countries and remains poorly characterized. From a birth cohort of 380 children, 65 malnourished infants received 12 weeks of nutritional supplementation with ready-to-use therapeutic food (RUTF). Eleven children with insufficient response to RUTF underwent upper endoscopy with duodenal biopsies, which were compared with U.S., age-matched specimens for healthy, celiac disease, non-celiac villous atrophy, non-celiac intraepithelial lymphocytosis, and graft-versus-host disease patients. Of the 11 children biopsied, EE was found in 10 (91%) with one subject with celiac disease. Morphometry demonstrated decreased villus-to-crypt (V:C) ratios in EE relative to healthy and non-celiac lymphocytosis patients. Environmental enteropathy villus volumes were significantly decreased relative to healthy controls. In EE, average CD3<sup>+</sup> cells per 100 epithelial cells and per 1,000 µm<sup>2</sup> of lamina propria and the number of lamina propria CD20<sup>+</sup> B-cell aggregates were increased relative to all other groups. Our results indicate that V:C ratios are reduced in EE but are less severe than in celiac disease. Environmental enteropathy intraepithelial and lamina propria T lymphocytosis is of greater magnitude than that in celiac disease. The increases in lamina propria B and T lymphocytes suggest that non-cytolytic lymphocytic activation may be a more prominent feature of EE relative to celiac disease. These results provide new insights into shared yet distinct histological and immunological features of EE and celiac disease in children.
Bopindolol in the treatment of hypertension: a double blind study comparing bopindolol and metoprolol. (1989)

The article presents the experience gained with a new betablocker- bopindolol-in the treatment of hypertension. Using a three-month double blind study conducted in 2 centres, the antihypertensive effect of bopindolol and metoprolol was compared in a total of 86 patients. The incidence of undesirable effects was determined, and biochemical parameters before and after therapy were followed up. Both drugs were equally effective in controlling blood pressure. In 70% of patients with mild and moderate hypertension, diastolic pressure values less than 95 mmHg were obtained in monotherapy with a betablocker. The incidence of undesirable effects was low, the drug was tolerated well. Biochemical parameters did not change within the three months of study.
Fullerene Inclusion Based on Horning-Crown Macrocycles (2008)

Horning-crown macrocycles, 1(R = (CH2)2) and 2(R = (CH2)3) form inclusion complexes with C60 and C70 fullerenes which have been structurally authenticated using X-ray diffraction data. Macrocycle 1 affords a C60 complex as a toluene solvate with overall composition C60(1)2(tol)2, 3, whereas the larger macrocycle, 2, affords complexes with both C60 and C70 fullerenes, also as toluene solvates: C60(2)(tol)2, (4); C70(2)(tol)2, (5); and C70(2)2(tol)2, (6). The higher degree of flexibility of such macrocyles relative to classical calixarenes is noteworthy in forming fullerene complexes, with the smaller ring size of 1 favoring fullerene complexation toward the smaller C60 molecule. The supramolecular assemblies involve host−guest interactions as well as interaction of fullerenes in zigzag chains with interfullerene contacts close to the van der Waals limit.
NOVEL SYNTHETIC IMMUNOTHERAPEUTIC VACCINES FOR CANCER (1992)

with the Applied Immuno- Oncology Research Group, the Breast Tumor Group and the Alberta Gyne-Oncology Group (Cross Cancer Institute, Edmonton, the Tom Baker Cancer Centre, Calgary, the University of Alberta, Edmonton, and Biomira Inc., Edmonton, Alberta, Canada).
Multicolor Cholesteric Liquid Crystal Display in a Single-Layered Configuration using a Multi-Pitch Stabilizations (2010)

We report a cholesteric liquid crystal (ChLC) display with multicolor in a single-layered configuration using a multi-pitch stabilization by reactive mesogen (RM). The cholesteric pitches were modulated by temperature and stabilized at room temperature by polymerization of the RMs through ultraviolet (UV) exposure. In a single-layered ChLC display without any additional layer such as a color filter, multicolor was obtained by a multi-pitch stabilization through spartially selective UV expose at several temperatures.
Nonlinear Fault Detection and Isolation for a Lithium-Ion Battery Management System (2010)

Lithium-ion batteries are a growing source for electric power, but must be maintained within acceptable operating conditions to ensure efficiency and reliability. Therefore, a robust fault detection and isolation scheme is required that is sensitive enough to determine when sensor or actuator faults present a threat to the health of the battery. A scheme suitable for a hybrid electric vehicle battery application is presented in this work. The diagnostic problem is formulated as a nonlinear parity equation approach, but is modified for the considered application. Sliding mode observers are designed for input estimation, while the output voltage estimation is performed using an open loop model. The selection of optimal thresholds given a maximum allowable probability of error is also considered. An assessment of the design using real-world driving-cycle data leads to the conclusion that the estimation error of the observers determines a lower bound on the minimum detectable fault magnitude.
Dimensional Changes of Nb<sub>3</sub>Sn Rutherford Cables During Heat Treatment (2016)

In high field magnet applications, Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn coils undergo a heat treatment step after winding. During this stage, coils radially expand and longitudinally contract due to the Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn phase change. In order to prevent residual strain from altering superconducting performances, the tooling must provide the adequate space for these dimensional changes. The aim of this paper is to understand the behavior of cable dimensions during heat treatment and to provide estimates of the space to be accommodated in the tooling for coil expansion and contraction. This paper summarizes measurements of dimensional changes on strands, single Rutherford cables, cable stacks, and coils performed between 2013 and 2015. These samples and coils have been performed within a collaboration between CERN and the U.S. LHC Accelerator Research Program to develop Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> Sn quadrupole magnets for the HiLumi LHC. The results are also compared with other high field magnet projects.