gebhart/patrepeval huggingface dataset:
Review 1: "Neutralization against B.1.351 and B.1.617.2 with sera of COVID-19 recovered cases and vaccinees of BBV152" (2021)

This paper presents reliable findings about the efficacy of BBV152 against VOCs B.1351 and B.1.617.2. Although the reviewers agree on the urgency and relevance of this paper they raised concerns about undisclosed affiliations of the authors and the sample size used in the study.
Communication Architecture for Autonomous Aerial Traffic Management (2022)

This paper presents a multi-agent communication paradigm for autonomous aerial traffic management. Multi-drone missions based on the existing ROS-based communication architecture heavily depend on the master node, and communication delay between nodes might not be sufficient for efficient inter-agent collision avoidance. In this paper, we have proposed a hybrid ROS-ROS2 communication architecture for centralised traffic management with the provision of distributed communication for collision avoidance and conflict resolution at intersections. The base station server responsible for traffic management runs on a ROS2 environment, ROS is used for communication with each onboard autopilot, and an intermediate add-on-module interfaces ROS and ROS2 messages. The content of the communication packets between the different nodes is decided based on the design requirements. Overall communication architecture is validated through simulation and hardware experiments.
Robust Beamformer Design in Active RIS-Assisted Multiuser MIMO Cognitive Radio Networks (2023)

In this work, we address the problem of a joint robust transmission, reflection and reception strategy design at an active reconfigurable intelligent surface (RIS)-assisted underlay multiple input multiple output (MIMO) cognitive radio networks in which a secondary transmitter serves multiple secondary receivers simultaneously. As such, we study the impact of imperfection in channel state information (CSI) at the secondary transmitter following a norm-bounded error model. A sum mean squared error (MSE) minimization problem is formulated by jointly optimizing the transmit beamforming matrix (BFM) at the secondary transmitter, the linear reception filters (LRF) at the secondary receivers and the reflection coefficient matrix (RCM) at the RIS subject to the constraints of available transmission power at the secondary transmitter, maximum allowed interference power towards the primary receiver and the permissible amplification range at each RIS element. Due to the coupled nature of the BFM, LRF and RCM variables, the formulated problem is non-convex and, thus, cannot be solved using conventional optimization methods. As a result, we propose an alternating optimization (AO) based iterative algorithm that determines the optimal BFM, LRF and RCM using semidefinite programming and inner approximation methods with guaranteed convergence. We also discuss the impact of the limited power budget at active RIS on the performance of the considered network. We present simulation-based numerical results to validate the efficacy and robustness of the proposed algorithm. Moreover, we also highlight the superiority of the use of the active RIS over passive RIS in the considered communication network.
MOBILE TRUST NEGOTIATION (2005)

We examine several architectures for extending the nascent technology of automated trust negotiation to bring nonidentity-based authentication and authorization to mobile devices. We examine how the location of trust agents and secure repositories affects such a system. We also present an implementation of one of these models. This protocol leverages software proxies, autonomous trust agents, and secure repositories to allow portable devices from different security domains (i.e., with no pre-existing relationship) to establish trust and perform secure transactions. This proposed system is called surrogate trust negotiation as the sensitive and resource-intense tasks of authentication are performed vicariously for the mobile device by a surrogate trust agent.
Laser-induced ultrasound transmitters for 3D photoacoustic and ultrasound tomography (2019)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Persistent identifiers: Consolidated assertions. Status of November, 2017. (2017)

Experts from 47 European research infrastructure initiatives and ERICs have agreed on a set of assertions about the nature, the creation and the usage of Persistent Identifiers (PIDs). This work was done in close synchronisation with the RDA Data Fabric Interest Group (DFIG) ensuring a global validation of the assertions. The intention of this cross-disciplinary report is to overcome still existing confusions about PIDs and the lack of detail knowledge in many disciplines. It is not meant to produce yet another comprehensive document on PIDs, but to identify agreements across documents that have been suggested to be included by experts. With this document GEDE (Group of European Data Experts in RDA Europe) is happy to help demystify PIDs, overcome confusion and create bridges between the various disciplines.
InGaAsP/InP photodiodes: Microplasma-limited avalanche multiplication at 1.0 to 1.3 &amp;amp;#181;m wavelength (1978)

Experiments with photodiodes for use in the 1 to 1.3 µm wavelength region, fabricated from LPE double-heterostructure InGaAsP/InP wafers, have shown that the avalanche multiplication in mesa-configuration devices was limited to values of 10 or less. The results of careful measurement of the photoresponse, quantum efficiency and reverse-bias I-V characteristics suggest that the gain was limited by microplasma breakdown.
Synthesis of 6,7,8,9‐tetrahydro‐5<i>H</i>‐pyrimido‐[4,5‐<i>b</i>][1,4]diazepine‐6,8‐diones (1993)

Abstract The sodium ethoxide catalyzed condensation of 4,5‐diaminopyrimidine ( 3 ) with diethyl malonate afforded 6,7,8,9‐tetrahydro‐5 H ‐pyrimido[4,5‐ b ][1,4]diazepine‐6,8‐dione ( 4 ). Methylation of 6,7,8,9‐tetrahydro‐5 H ‐pyrimido[4,5‐ b ][1,4]diazepine‐6,8‐dione ( 4 ) using sodium hydride and two equivalents of iodomethane gave 5,9‐dimethyl‐6,7,8,9‐tetrahydro‐5 H ‐pyrimido[4,5‐ b ][1,4]diazepine‐6,8‐dione ( 5 ) which on further methylation using sodium hydride and one equivalent iodomethane yielded 6,7,8,9‐tetrahydro‐5,7,9‐trimethyl‐5 H ‐pyrimido[4,5‐ b ][1,4]diazepine‐6,8‐dione ( 6 ). Reaction of 6,7,8,9‐tetrahydro‐5 H ‐pyrirnido[4,5‐ b ][1,4]diazepine‐6,8‐dione ( 4 ) with 4.2 equivalents of sodium hydride and 4.1 equivalents of iodomethane afforded 6,7,8,9‐tetrahydro‐5,7,7, 9‐tetramethyl‐5 H ‐pyrimido[4,5‐ b ][1,4]diazepine‐6,8‐dione ( 7 ). 6,7,8,9‐Tetrahydro‐5,7,7,9‐tetramethyl‐5 H ‐pyrimido[4,5‐ b ][1,4]diazepine‐6,8‐dione ( 7 ) exhibited weak anticonvulsant activities in the subcutaneous pentylenetetrazole and maximal electroshock anticonvulsant screens indicating it is a partial bioisostere of the anticonvulsant drug clobazam ( 2 ).
Safety and efficacy of compounded bioidentical hormone therapy (cBHT) in perimenopausal and postmenopausal women: a systematic review and meta-analysis of randomized controlled trials (2022)

This review found that cBHT used in primarily short-term RCTs is not associated with adverse changes in lipid profile or glucose metabolism. cBHT in the form of vaginal androgens appears beneficial for vaginal atrophy symptoms. There are insufficient RCTs of cBHT to assess clinical risk of breast cancer, endometrial cancer, or cardiovascular disease. Long-term studies with clinical endpoints are needed.
Cloning and expression of bacteriophage FMV lysocyme gene in cells of yeasts Saccharomyces cerevisiae and Pichia pastoris (2010)

Cloning, sequencing, and expression of the gene for soluble lysozyme of bacteriophage FMV from Gram-negative Pseudomonas aeruginosa bacteria were conducted in yeast cells. Comparable efficiency of two lysozyme expression variants (as intracellular or secreted proteins) was estimated in cells of Saccharomyces cerevisiae and Pichia pastoris. Under laboratory conditions, yeast S. cerevisiae proved to be more effective producer of phage lysozyme than P. pastoris, the yield of the enzyme in the secreted form being significantly higher than that produced in the intracellular form.
High-performance GaN metal–insulator–semiconductor ultraviolet photodetectors using gallium oxide as gate layer (2011)

In this study, gallium nitride (GaN)-based metal-insulator-semiconductor (MIS) ultraviolet (UV) photodetectors (PDs) with a gallium oxide (GaO(x)) gate layer formed by alternating current bias-assisted photoelectrochemical oxidation of n-GaN are presented. By introducing the GaO(x) gate layer to the GaN MIS UV PDs, the leakage current is reduced and a much larger UV-to-visible rejection ratio (R(UV/vis)) of spectral responsivity is achieved. In addition, a bias-dependent spectral response results in marked increase of the R(UV/vis) with bias voltage up to ~10(5). The bias-dependent responsivity suggests the possible existence of internal gain in of the GaN MIS PDs.
Surface Doping Boosts Triplet Generation Yield in Perovskite‐Sensitized Upconversion (2022)

Abstract Triplet–triplet annihilation‐based photon upconversion (TTA‐UC) can efficiently generate higher energy photons at low relative fluences. Bulk metal halide perovskites have offered promise in efficiently sensitizing molecular triplet states in the solid state, necessary for the integration of TTA‐UC into device‐based applications. Recent work focused on TTA‐UC from a rubrene triplet annihilator sensitized by perovskite thin films has established relatively efficient charge extraction from the perovskite, forming the triplet exciton in rubrene. Yet, the specifics underpinning charge transfer at the perovskite/rubrene interface are not fully elucidated. To improve device performance and study the properties governing charge transfer at the interface, various organic solvents are explored to treat the perovskite surface. Scanning tunneling microscopy and spectroscopy show a difference in the electronic band structure, where both n‐ and p‐type terminated perovskite surfaces are observed depending on the solvent used. Supported by optical spectroscopy, the impact of the perovskite electronic structure is monitored, indicating that n‐type perovskite sensitizers feature higher TTA‐UC efficiencies due to favorable band bending resulting in efficient hole‐mediated triplet formation. Overall, the tuning of the electronic structure of the perovskite sensitizer through solvent treatment is shown to be a key force in tuning the mechanism of efficient triplet generation.
IntelliMS: A platform to efficiently manage and visualize tandem mass spectral data (2008)

With the development of high-speed mass spectrometric techniques, it becomes important to manage large amounts of spectrometric data accurately. We have developed a new data management system with a visualization function named IntelliMS, which can load data into a search engine, filter out the insignificant data, create diagrams of the identification process from spectra to protein and share all the resulting datasets. This software can be used to efficiently manage complicated mass spectral data and the corresponding protein identification information obtained from various proteomics analyses.
Angular correlation between<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>K</mml:mi></mml:math>and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>L</mml:mi></mml:math>x rays in tantalum (1975)

Angular correlations between $K$ and $L$ x rays in Ta obtained from the electron-capture decay of $^{181}\mathrm{W}$ were measured using two different experimental systems. High-resolution Si(Li) x-ray detectors were used to detect $L$ x rays. $K$ x rays were detected with a high-resolution Ge(Li) spectrometer in one experiment and a NaI(T1) crystal in the other experiment. The adopted values for the $K{\ensuremath{\alpha}}_{1}\ensuremath{-}Ll$ $K{\ensuremath{\alpha}}_{1}\ensuremath{-}L{\ensuremath{\alpha}}_{1+2}$, and $K{\ensuremath{\alpha}}_{1}\ensuremath{-}L\ensuremath{\beta}$ cascades are ${A}_{22}=(24\ifmmode\pm\else\textpm\fi{}3)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}2}$, ${A}_{22}=(3.2\ifmmode\pm\else\textpm\fi{}0.2)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}2}$, and ${A}_{22}=(3.4\ifmmode\pm\else\textpm\fi{}0.9)\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}2}$, respectively. The results for the $K{\ensuremath{\alpha}}_{1}\ensuremath{-}L\ensuremath{\alpha}$ cascade agree with theoretical predictions but the results for the $K{\ensuremath{\alpha}}_{1}\ensuremath{-}Ll$ and $K{\ensuremath{\alpha}}_{1}\ensuremath{-}L\ensuremath{\beta}$ cascade are slightly lower than predicted.
Design and Analysis of a New Enhanced Torque Hybrid Switched Reluctance Motor (2018)

In this paper, a new 6/10 hybrid switched reluctance motor (HSRM) is proposed. This original topology deploys permanent magnets (PMs) between adjacent stator poles of a divided teeth SRM. The function of the PMs is to weaken the magnetic saturation in stator poles, which is a major obstacle of torque improvement for divided teeth SRMs. Besides, the magnetic flux in the airgap increases as well. Hence, the output torque can be increased significantly. The flux distribution of the topology is analyzed by using an equivalent magnetic circuit. The topology is optimized by using the genetic algorithm for the best torque performance. Additionally, the characteristics of the proposed topology are compared with a 12/10 SRM, a 6/10 two-teeth SRM, a 12-slot, 10-pole three-phase six-state PM brushless DC motor, and a flux switching permanent magnet motor of the same dimension. A prototype of the proposed topology is built for experimental verification. The simulation and experimental results indicate that the proposed topology can achieve high torque density and high PM utilization factor simultaneously.
A New and Convenient Synthesis of 1-Aryl-2-dimethylaminoethanols (2002)

An efficient two-step synthesis of 1-aryl-2-dimethylaminoethanols 4 is described, consisting of oxazolidine 3 generation from the cycloaddition of an azomethine ylide to an aldehyde, followed by reductive ring-opening.
PREVALENCE OF PRIMARY ALDOSTERONISM (PA) IN NEWLY DIAGNOSED HYPERTENSIVE PATIENTS (2004)

: Tuesday, June 15, 2004: ORAL SESSION: Oral Session 5B: Vasoactive Substances and Neurohormones
Analysis of interconnection of photovoltaic distributed generation (2011)

Rapid growth of grid-connected photovoltaic distributed generation (PV-DG) provides many benefits such as clean energy, reduced emissions and creation of new green jobs. However, given its intermittent nature, large scale penetration of PV-DG may challenge the quality and reliability of the grid. This paper evaluates the impact of PV-DG on distribution system voltages. The paper describes the models used for the study, discusses the impacts of PV-DG, and presents the results of detailed simulations. The results show that PV-DG can cause both steady-state and transient overvoltages along the feeder, and may create additional tap operations of line voltage regulators. Finally, the paper proposes a mitigation strategy to eliminate overvoltages, reduce additional tap operations, and validates the proposed method with simulation results.
LEADER 3—Lipase and Amylase Activity in Subjects With Type 2 Diabetes (2014)

In this large study of type 2 diabetic patients, nearly 25% had elevated lipase or amylase levels without symptoms of acute pancreatitis. The clinician must take these data into account when evaluating abdominal symptoms in type 2 diabetic patients.
Coupled forebrain increases of local cerebral glucose utilization and blood flow during physiologic stimulation of a somatosensory pathway in the rat (1987)

To investigate the relationships of local cerebral glucose utilization (lCMRgl) and blood flow (lCBF) during physiologic activation, awake Wistar rats received unilateral stimulation of the large facial whiskers (vibrissae) and were studied by carbon-14 double-label autoradiography. Activation was followed by increased lCMRgl and lCBF in appropriate forebrain structures. There was an overall preservation of metabolism/blood flow coupling during periods of somatosensory activation despite small but significant increases (14 to 22%) in the coupling ratio of the barrel field. Prolonged activation may give rise to an intracortical redistribution of lCBF within the barrel field.
Data from HDAC Inhibition Enhances the &lt;i&gt;In Vivo&lt;/i&gt; Efficacy of MEK Inhibitor Therapy in Uveal Melanoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;The clinical use of MEK inhibitors in uveal melanoma is limited by the rapid acquisition of resistance. This study has used multiomics approaches and drug screens to identify the pan-HDAC inhibitor panobinostat as an effective strategy to limit MEK inhibitor resistance.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Mass spectrometry–based proteomics and RNA-Seq were used to identify the signaling pathways involved in the escape of uveal melanoma cells from MEK inhibitor therapy. Mechanistic studies were performed to evaluate the escape pathways identified, and the efficacy of the MEK-HDAC inhibitor combination was demonstrated in multiple &lt;i&gt;in vivo&lt;/i&gt; models of uveal melanoma.&lt;/p&gt;Results:&lt;p&gt;We identified a number of putative escape pathways that were upregulated following MEK inhibition, including the PI3K/AKT pathway, ROR1/2, and IGF-1R signaling. MEK inhibition was also associated with increased GPCR expression, particularly the endothelin B receptor, and this contributed to therapeutic escape through ET-3–mediated YAP signaling. A screen of 289 clinical grade compounds identified HDAC inhibitors as potential candidates that suppressed the adaptive YAP and AKT signaling that followed MEK inhibition. &lt;i&gt;In vivo&lt;/i&gt;, the MEK-HDAC inhibitor combination outperformed either agent alone, leading to a long-term decrease of tumor growth in both subcutaneous and liver metastasis models and the suppression of adaptive PI3K/AKT and YAP signaling.&lt;/p&gt;Conclusions:&lt;p&gt;Together, our studies have identified GPCR-mediated YAP activation and RTK-driven AKT signaling as key pathways involved in the escape of uveal melanoma cells from MEK inhibition. We further demonstrate that HDAC inhibition is a promising combination partner for MEK inhibitors in advanced uveal melanoma.&lt;/p&gt;&lt;/div&gt;
&lt;title&gt;New Developments In X-Ray Imaging Systems&lt;/title&gt; (1974)

I hope that we all agree that the goal of radiologic imaging is good diagnostic accuracy combined with low radiation exposure. I am dismayed, however, whenever I hear the statement that we are all working to &quot;Maximize diagnostic accuracy and minimize patient exposure&quot; because I feel strongly that this statement somewhat subtly clouds a central and crucial problem in the evaluation of diagnostic image quality. I believe that we can never hope to maximize diagnostic accuracy and minimize patient exposure simultaneously because we can always buy a little more diagnostic accuracy at the expense of a little more patient exposure, or reduce exposure a bit at the cost of some loss in diagnostic usefullness.
Biological Effects and Use of PrP <sup>Sc</sup> - and PrP-Specific Antibodies Generated by Immunization with Purified Full-Length Native Mouse Prions (2011)

The prion agent is the infectious particle causing spongiform encephalopathies in animals and humans and is thought to consist of an altered conformation (PrP(Sc)) of the normal and ubiquitous prion protein PrP(C). The interaction of the prion agent with the immune system, particularly the humoral immune response, has remained unresolved. Here we investigated the immunogenicity of full-length native and infectious prions, as well as the specific biological effects of the resulting monoclonal antibodies (MAbs) on the binding and clearance of prions in cell culture and in in vivo therapy. Immunization of prion knockout (Prnp(0/0)) mice with phosphotungstic acid-purified mouse prions resulted in PrP-specific monoclonal antibodies with binding specificities selective for PrP(Sc) or for both PrP(C) and PrP(Sc). PrP(Sc)-specific MAb W261, of the IgG1 isotype, reacted with prions from mice, sheep with scrapie, deer with chronic wasting disease (CWD), and humans with sporadic and variant Creutzfeldt-Jakob disease (CJD) in assays including a capture enzyme-linked immunosorbent assay (ELISA) system. This PrP(Sc)-specific antibody was unable to clear prions from mouse neuroblastoma cells (ScN2a) permanently infected with scrapie, whereas the high-affinity MAb W226, recognizing both isoforms, PrP(Sc) and PrP(C), did clear prions from ScN2a cells, as determined by a bioassay. However, an attempt to treat intraperitoneally prion infected mice with full-length W226 or with a recombinant variable-chain fragment (scFv) from W226 could only slightly delay the incubation time. We conclude that (i) native, full-length PrP(Sc) elicits a prion-specific antibody response in PrP knockout mice, (ii) a PrP(Sc)-specific antibody had no prion-clearing effect, and (iii) even a high-affinity MAb that clears prions in vitro (W226) may not necessarily protect against prion infection, contrary to previous reports using different antibodies.
A Tc-99m-labeled long chain fatty acid analog metabolized by the heart (2006)

1888 Objectives: Development of 99mTc-labeled long chain fatty acid analogues metabolized by beta-oxidation in myocardium still constitutes an unsettled challenge. A recent study showed that [188Re]tricarbonyl (carboxycyclopentadienyl) rhenium was recognized as an aromatic compound and metabolized as such by the body. Based on these findings, cyclopentadienyltricarbonyltechnetium (CpTT) was conjugated to the ω-position of pentadecanoic acid to prepare CpTT-PA. Biodistribution and myocardial metabolism of CpTT-PA were investigated in rats to estimate the chemical design for developing 99mTc-labeled fatty acid analog. Methods: The ferrocene precursor, 15-ferrocenoyl- tetradecanoic acid methyl ester was prepared by Friedel-Crafts reaction using ferrocene and 1-methyl pentadecanoic acid chloride in the presence of AlCl3. CpTT-PA was prepared by the double ligand transfer reaction of the ferrocene precursor with 99mTcO4-, followed by the reduction of acyl-CpTT to alkyl-CpTT and subsequent hydrolysis of the methyl ester. The chemical structure of CpTT-PA was confirmed by HPLC using well-characterized rhenium compound as a reference. Biodistribution studies were performed after intravenous injection of CpTT-PA to rats. SPECT images were also taken after injection of CpTT-PA to rats. Myocardial metabolism of CpTT-PA was assessed using the isolated Langendorff-perfusded rat heart model. Results: CpTT-PA was obtained with radiochemical yield and purity of 10.1 % and over 93 %, respectively. When injected to rats, CpTT-PA exhibited the highest myocardial accumulation of 3.85 %ID/g at 1 min postinjection, followed by a gradual decrease with times. Due to the faster clearance of radioactivity from the blood, CpTT-PA registered the heart- to-blood ratios of radioactivity of 2.93, 4.60 and 3.44 at 5, 10 and 30 min postinjection. Myocardial accumulation of CpTT-PA was also confirmed by SPECT studies. The metabolic study using isolated Langendorff-perfused rat hearts demonstrated that the major radiometabolite in the perfusate and in the myocardium had a retention time identical to that of 4-cyclopentadienyltricarbonyltechnetium butyric acid, the metabolite after six cycles of beta-oxidation of CpTT-PA. Conclusions: CpTT-PA exhibited significant myocardial accumulation and heart-to-blood ratios of radioactivity, which visualized rat myocardium by SPECT. CpTT-PA was also recognized as a substrate for beta-oxidation by the myocardium. These findings indicated that CpTT-PA would constitute a potential candidate for SPECT-based myocardial metabolic studies.