gebhart/patrepeval huggingface dataset:
Electrorheological Response of Silicone Oil Suspension of Barium Strontium Titanate Particles with Different Surface Compositions (2005)

Electrorheological response of barium strontium titanate (BST)/silicone oil suspension was experimentally studied with measurements of generated shear stress in a range of field frequency (200-4000 Hz) under steady shear. The BST particles were synthesized by the hydrolysis of complex alkoxide precursor that was prepared in a reflux of metallic barium, metallic and tetraethylorthotitanate in solvent. The hydrolysis was performed by the addition of water/ethanol solution to the precursor solution. Generated shear stress of as-prepared (unannealed) BST particles system decreased with an increase in frequency, while that for 1100 °C-annealed BST system increased with frequency. XPS measurements revealed that alkoxyl groups that were derived from unreacted alkoxide were on surface of the as-prepared BST particles, and the annealing at 1100 °C decomposed the alkoxyl groups to hydroxyl groups. Difference in electric conductivities of the surfaces is considered to be responsible for the different shear stress behaviors of the as-prepared and annealed particles.
Temperature-dependent Lowering of Coercive Field in 300 nm Sputtered Ferroelectric Al<sub>0.70</sub>Sc<sub>0.30</sub>N (2021)

This paper reports the temperature-dependent ferroelectric properties of sputtered ferroelectric Al0.70Sc0.30N. The coercive field is experimentally demonstrated to decrease by 1.5 MV/cm in 300 nm films in the temperature range of 20- 193 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> C, corresponding to an average linear coefficient of decrease of 8.8 kV/ <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> C. In the same range, the remnant polarization varies by 23.5% between 90-114 μC/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> without a significant drop-off at higher temperatures. Thermally cycling the chip between room temperature and the highest achievable temperature of 193 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0</sup> C shows a reversible tuning of the coercive field, paving the path towards on-chip ovenization-based control of ferroelectric properties. The dielectric breakdown under AC and DC testing are driven by filamentary and thermally driven breakdown processes respectively. These breakdown processes suggest the potential for high frequency operation of sputtered Al0.70Sc0.30N as a ferroelectric thin film at elevated temperatures with low leakage.
Stabilization of an unmanned aerial vehicle using real-time embedded motion estimation (2012)

This paper presents an image-based velocity control method for a VTOL UAV. For increased autonomy, a real-time embedded global motion estimation process using efficient feature tracking was developed. The VTOL vehicle is assumed to be equipped with a minimum sensor suite - i.e. a camera, altitude sensor and IMU - and to hover over a featured flat plane. This paper first presents a fast feature-based global motion estimation method, and then proposes a control strategy based on this method. Finally, experimental results using a quadrotor demonstrate the performance of the proposed control strategy and feature-based motion estimation.
Bioactive Marine Metabolites. Part 127. Three New Cyclostellettamines, which Inhibit Histone Deacetylase, from a Marine Sponge of the Genus Xestospongia (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Characterization of anti-cancer immune response associated with immune-related adverse events in patients with kidney cancer. (2023)

711 Background: Some reports showed promising clinical efficacy among patients who discontinued immune checkpoint inhibitors (ICIs) due to immune-related adverse events (irAEs). In this study, we aimed to characterize T cell receptor (TCR) repertoire repertoire in peripheral blood mononuclear cells (PBMCs) before and after ICI treatment, and at the onset of irAE for understanding of irAE-provoked anti-cancer immune responses. Methods: We collected metastatic tumor tissues and peripheral blood samples from 54 patients with advanced kidney cancer before anti-programmed cell death protein 1 (PD-1) treatment and 1 month after treatment initiation. Furthermore, we applied a next-generation sequencing approach to characterize TCR repertoires using tumor tissues and PBMCs. Results: The number of irAEs was significantly higher in responder for nivolumab (p &lt; 0.0001). We also confirmed that irAE present patients had better progression-free survival and overall survival when compared to irAE absent patients (p=0.0010 and p=0.011, respectively). TCR repertoire analysis revealed that diversity index for TCR alpha and beta in irAE present patients were significantly decreased at 1 month after nivolumab, indicating expansion of certain T cell clones even in PBMCs after nivolumab. We also examined morishita index to measure T cell similarity between pre- and post nivolumab samples. As a result, irAE present patients had significantly lower similarity than irAE absent patients, indicating a larger change in the T cell clones, and inducing newly expanded T cell clones in post-nivolumab PBMC samples. Importantly, irAE present patients had significantly higher numbers of peripheral T cell clones shared with metastatic tumor-infiltrating T cells than those in irAE absent patients at 1 month after nivolumab (as per the 100 most abundant T cell clonotypes in the peripheral blood; p=0.038). Conclusions: Our findings revealed that a certain number of irAE-provoked T cell clones can also circulate systemically and attack tumor cells in distant regions, leading to durable response in the patients with irAEs.
Mechanical Strain Stimulates ROS Cell Proliferation Through IGF-II and Estrogen Through IGF-I (1999)

The mechanism by which mechanical strain stimulates bone cell proliferation was investigated and compared with that of estrogen in ROS 17/2.8 cells. Similarity of strain-related responses between ROS cells and osteoblasts was established by demonstrating that ROS cells respond to a short single period of strain in their substrate (1000-3500 microepsilon, 600 cycles, 1 Hz) by a similar strain magnitude-related increase in glucose 6-phosphate dehydrogenase activity as rat osteoblasts and osteocytes in explants in situ. ROS17/2.8 cells also showed similar proliferative responses to strain and 17beta-estradiol, as assessed by [3H]thymidine incorporation and cell counting, as primary cultures of long bone-derived osteoblast-like cells. Strain-related increase in proliferation in ROS cells was accompanied by a 4-fold increase in levels of insulin-like growth factor-II (IGF-II) in conditioned medium. Neither strain nor estrogen had an effect on the conditioned medium levels of IGF-I. Exogenous truncated IGFs tIGF-I and tIGF-II both increased proliferation in a dose-dependent manner. The neutralizing monoclonal antibody (nMAb) to IGF-I blocked proliferation stimulated by tIGF-I but not that due to tIGF-II and vice versa. IGF-I receptor blocking antibody (IGF-IRBAb) blocked the proliferative effect of tIGF-I but not that to tIGF-II. The proliferative effect of estrogen was abolished by IGF-I nMAb and IGF-IRBAb, but these antibodies had no effect on the proliferative response to strain. In contrast IGF-II nMAb abolished the proliferative effect of strain but had no effect on that of estrogen. These data show that ROS17/2.8 cells have similar responses to strain and estrogen qualitatively and quantitatively as rat osteoblasts in situ and rat long bone-derived osteoblast-like cells in primary culture. Estrogen-related proliferation in ROS17/2.8 cells appears to be mediated by IGF-I acting through the IGF-I receptor and does not involve IGF-II. In contrast, strain-related proliferation appears to be mediated by IGF-II and does not involve either IGF-I or the IGF-I receptor.
Antibiotic sensitivity and resistance in<i>Ornithobacterium rhinotracheale</i>strains from Belgian broiler chickens (2001)

Establishing the antibiotic sensitivity of the avian respiratory pathogen Ornithobacterium rhinotracheale is difficult because of the organism's complex growth requirements and the unusually frequent occurrence of resistance. The minimal inhibitory concentrations of 10 antibiotics were determined for 45 strains of O. rhinotracheale from Belgian broiler chickens collected from 45 farms between 1995 and 1998. They were compared with the type strain, which was isolated from a turkey, and a strain isolated from a rook. All the broiler strains were resistant to lincomycin and to the beta-lactams ampicillin and ceftiofur. Less than 10% of the strains were sensitive to the macrolides tylosin and spiramycin, tilmicosin and flumequine. A few strains were sensitive to enrofloxacin and doxycycline. All strains were sensitive to tiamulin.
Thyrotropin-Induced Hyperthyroidism: Use of Alpha and Beta Subunit Levels to Identify Patients with Pituitary Tumors (1977)

Six hyperthyroid patients with inappropriately elevated serum thyrotropin (TSH) had serum concentrations of the common alpha subunit of the glycoprotein hormones (alpha) and the beta subunit of TSH (TSH-β) measured by radioimmunoassay. The three patients with a pituitary tumor had markedly elevated serum alpha levels of 105, 16.6, and 19.5 ng/ml and TSH of 34, 1.7, and 5.6 εU/ml, yielding molar alpha to TSH ratios of 31 to 98; TSH-β was not detected (<;0.5 ng/ml). The three patients without a pituitary tumor had serum alpha concentrations of 1.2, 0.5, and 1.0 ng/ml and serum TSH levels of 160, 9.3, and 90 εU/ml, yielding molar alpha to TSH ratios <1; TSH-β was 1.3, 0.5, and 0.5 ng/ml. Subunit and TSH secretion in the patients with a pituitary tumor demonstrated little or no change after thyrotropin releasing hormone (TRH) or thyroid hormone administration. In contrast, serum subunit and TSH levels increased after TRH in the patients withou a pituitary tumor; both basal and peak subuni and TSH levels after TRH decreased after th* administration of thyroid hormone although the] were still inappropriately high in relation to th* elevated serum thyroid hormone levels. In botl the tumor and non-tumor patients, alpha subuni and TSH concentrations decreased after the administration of dexamethasone. Inthe patients with; pituitary tumor, hypophysectomy followed by radiotherapy caused a decrease in serum alpha and TSf concentrations, as well as remission of hyperthyroidism. Thepresence of elevated serum alph; concentrations and undetectable TSH-β in patientswith TSH-induced hyperthyroidism may serve to identify those patients with a pituitary tumor and in certain patients the reduction of serum alph; may better indicate the adequacyof therapy,
Low‐noise gaas MESFET optimization using an orthogonal array approach (1994)

Abstract This article presents an experimental optimization of the noise figure of small‐signal self‐aligned FETs. An L 18 orthogonal array has been used to find the main effects of specific device parameters on noise performance at 18 GHz. This knowledge has been used to find an alternative device which shows a ∼0.7‐dB improvement in noise measure without requiring major process changes. Hybrid low‐noise amplifiers built with the improved FETs confirm the noise performance and show record power performance for high dynamic range applications. © 1994 John Wiley &amp; Sons, Inc.
LOW-POWER DIODE LASER STIMULATION OF SURGICAL OSTEOCHONDRAL DEFECTS: RESULTS AFTER 24 WEEKS (2001)

The purpose of this study was to evaluate osteochondral lesions of the knee, treated intraoperatively with low-power laser stimulation, and assess results at 24 weeks. Surgery was performed under general anesthesia on six rabbits; a bilateral osteochondral lesion was created in the femoral medial condyles with a drill. All of the left lesions underwent immediate stimulation using the diode Ga-Al-As laser (780nm), whereas the right knees were left untreated as control group. After 24 weeks, the explants from the femoral condyles, either treated employing laser energy or left untreated, were examined histomorphometrically. Results obtained on the lased condyles showed good cell morphology and a regular aspect of the repaired osteocartilaginous tissue.
Chemical and Genetic Sensors in Biomedical Research (2005)

The <i>Journal of Biomedical Optics</i> (JBO) is a Gold Open Access journal that publishes peer-reviewed papers on the use of novel optical systems and techniques for improved health care and biomedical research.
An Easy Regio- and Stereoselective Synthesis of a Versatile Trisaccharide Precursor for Synthetic Carbohydrate Based Vaccines (2007)

The trisaccharide allyl 2-deoxy-2-phthalimido-6- O -[4- O -(2,3,4,6-tetra- O -benzoyl-β-D-galactopyranosyl)-2,3,6-tri- O -benzoyl-β-D-glucopyranosyl]-β-D-glucopyranoside ( 3 ) was prepared directly from acceptor allyl 2-deoxy-2-phthalimido-β-D-glucopyranoside ( 1 ) and 4- O -(2,3,4,6- tetra- O -benzoyl-β-D-galactopyranosyl)-2,3,6-tri- O -benzoyl-α-D-glucopyranosyl trichloroacetimidate ( 2c ) using regio- and stereoselective synthesis in dichloromethane with trimethylsilyl triflate as a promoter.
Effectiveness of repetitive trancranial or peripheral magnetic stimulation in neuropathic pain (2016)

Repetitive transcranial magnetic stimulation of the primary motor cortex using high frequency stimulation protocols can effectively reduce neuropathic pain, particularly in individuals with pain related to non-cerebral lesions. The application of multiple sessions can lead to long-lasting pain modulation and cumulative effects. Implications for Rehabilitation Maladaptive plasticity plays a central role in sensitization of nociceptive pathways, generation and maintainance of neuropathic pain; Most neuropathic pain conditions are refractory to pharmacological therapies; Repetitive magnetic stimulation of the central and peripheral nervous system has gained relevance as noninvasive approach for neuromodulation and pain relief.
A microfluidic approach for generating steady-state oxygen gradients in 3-D matrices (2011)

A novel micro fabricated tool has been developed that can expose in vitro cells cultured in three-dimensional scaffolds to steady-state oxygen gradients. The polydimethylsiloxane (PDMS) device encloses cells seeded in 3-D constructs such as collagen or agarose, and permits the formation of steady-stage oxygen gradients. A fluorescent oxygen sensor was used to validate the establishment of a gradient across the constructs. Additionally, a Live-Dead stain was used to confirm the viability of a cell model cultured in the device after two days, demonstrating that the device has no adverse effects on the cells.
AAV Rep protein-dependent expression of GFP. (2015)

&lt;p&gt;(A) Induction of GFP expression in blasticidin-S resistant Sf9/ITR-GFP cells in response to Bac-Rep infection. The clonal Sf9/ITR-GFP cell line contains a stably integrated copy of pFBGR-bsd. Uninfected cells or cells infected with wild-type baculovirus (Bac-AcNPV) lack detectable GFP expression as determined by FACS analysis. (upper row, 0% GFP positive cells). Addition of Bac-Rep inoculum (0.5%, 1.0%, and 1.5%; v:v) resulted in a dose-dependent increase in the number of GFP-positive cells (lower row). Images were obtained 3 days after infection. Magnification, 10x objective used for all images. (B) Quantitative analysis of GFP induction as a function of Bac-Rep dose. Cells exposed to increasing doses of Bac-Rep were harvested on day 3 post-infection. Fluorescent emission intensities were assessed from equivalent amounts of cell lysates (80 µg protein), using the fluorescent reader function of a real-time thermocycler (excitation 450–490 nm; emission 515–530 nm) (upper panel), *** indicates t-test significance (p&lt;0.001). The relative fold-increase in GFP fluorescence is indicated by the values next to each bar. Protein concentrations were determined in the lysates and approximately 120 µg of each sample was fractionated electrophoretically using SDS-polyacrylamide gels. Proteins were electroblotted onto nitrocellulose membranes for western blot detection of GFP, Rep52, gp64, and GAPDH (used as a protein loading and transfer standard, lower panel). Relative levels of protein are indicated by the values above the protein band. (C) Analysis of the increase of GFP-vector DNA in response to Bac-Rep infection. Low molecular weight DNA was recovered from the cells and the quantity of GFP vector genomes determined using real-time qPCR (upper panel). Both the uninfected cell control and the wild-type baculovirus-infected cell control lysates produced a relatively low PCR signal (150 and 175 copies per cell, respectively). The GFP vector DNA copy number increased to 21087 copies per cell with 0.5% (v:v) Bac-Rep. At 1% (v:v) Bac-Rep, the copy number increased to 28862 copies per cell and 1.5% (v:v) Bac-Rep increased the copy number to 38286 per cell. The statistical significance was determined by Student's t-test. ***, p&lt;0.001. Lower panel – The samples were analyzed by agarose-ethidium bromide gel electrophoresis (1% agarose). No detectable CELiD DNA was recovered from uninfected cells. A band &gt;10 kb appears in lysates from all baculovirus-infected cells. (D) Time-course of GFP fluorescence. Sf9/ITR-GFP cells were inoculated with either wtBac (Bac-ACNPV) or Bac-Rep (0.5%, 1%, and 1.5% (v:v)). GFP fluorescence was measured for the indicated cellular lysate at 1, 2, and 3 days post-infection.&lt;/p&gt;
Leptin Concentrations in Relation to Body Mass Index and the Tumor Necrosis Factor-α System in Humans<sup>1</sup> (1997)

The expression of leptin, an adipocyte-derived protein whose circulating levels reflect energy stores, can be induced by tumor necrosis factor (TNF)alpha in rodents, but an association between the TNF alpha system and leptin levels has not been reported in humans. To evaluate the potential association between serum leptin and the TNF alpha system, we measured the levels of soluble TNF alpha-receptor (sTNF alpha-R55), which has been validated as a sensitive indicator of activation of the TNF alpha system. We studied two groups: 1) 82 young healthy normal controls and 2) 48 patients with noninsulin dependent diabetes mellitus (NIDDM) and 24 appropriately matched controls. By simple regression analysis in controls, there was a strong positive association between leptin and 3 parameters: body mass index, sTNF alpha-R55, and insulin levels. In a multiple regression analysis model, leptin remained significantly and strongly associated with body mass index, and the association of leptin with both insulin and sTNF alpha-R55, although weakened, remained significant. Patients with NIDDM had leptin concentrations similar to controls of similar weight. Importantly, serum levels of sTNF alpha-R55 were also positively and independently associated with leptin in this group of diabetic subjects and matched controls. These data are consistent with the hypothesis that the TNF alpha system plays a role in regulating leptin levels in humans. Further elucidation of a possible role of the TNF alpha system in leptin expression and circulating levels may have important implications for our understanding of obesity and cachexia in humans.
Thermochemical and transport properties important to molten salt reactor operation: Off-gas performance and the fission product mechanistic source term (2018)

The source term used in reactor performance and safety analysis requires understanding the chemical speciation and transport behavior of fission and activation products in the primary heat transport system (PHTS) and containment. As a starting condition, the transport models will use the isotopic compositions determined through ORIGEN (Bell 1973) calculations and thermochemistry that describes the speciation of the fuel, the salt, activation products and fission products. However, as changes in phase will be under non-equilibrium conditions, the source terms will also need models for the transport behavior of key compounds in the PHTS under various scenarios: normal operation with and without an off-gas system, maintenance, off-normal events, and severe reactor accidents. This document highlights those mechanistic behaviors for which models are needed. Simulations of reactor behavior require these models to be developed for molten salt reactors (MSRs), especially if not part of the suite used in describing LWR behavior. The document concludes with recommendations how to develop these models based on what is already known about reactor safety and fission product behavior.
Hydroxymercuration-reductive coupling route to .delta.-lactones. Synthesis of malyngolide, an antibiotic from a marine blue-green alga (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroxymercuration-reductive coupling route to .delta.-lactones. Synthesis of malyngolide, an antibiotic from a marine blue-green algaAlan P. Kozikowski, Thaddeus R. Nieduzak, and James ScripkoCite this: Organometallics 1982, 1, 4, 675–676Publication Date (Print):April 1, 1982Publication History Published online1 May 2002Published inissue 1 April 1982https://pubs.acs.org/doi/10.1021/om00064a018https://doi.org/10.1021/om00064a018research-articleACS PublicationsRequest reuse permissionsArticle Views192Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Second harmonic generation in non-electrically-poled NLO polymers excited by surface plasmon enhanced electric field (2013)

We will report second harmonics generations (SHG) in nonlinear optical (NLO) polymers excited by Surface Plasmon (SP) enhanced fields. The surface plasmon polariton was excited in an attenuated total reflection geometry having the Kretchmann configuration. Here, the NLO interactions occurred in the thin films of the NLO polymers, consisting of Disperse Red 1 as guest chromophores and PMMA as host, coated on Ag thin films. Our experimental results indicated that NLO polymers emitted strong SHG signals in the SP resonance conditions. The SHG intensities from NLO polymer coated Ag films were more than 10 times higher than those of the uncoated Ag films. The measurements were conducted for the polymer films with different thickness between 10 and 100 nm. All of the samples with different polymer thickness exhibited the SHG signals at its SP resonance condition that depends on the film thicknesses. The highest SHG conversion efficiency was recorded from the sample with 40 nm film thicknesses. The <i>p</i>-polarized pump beams gave the highest SHG conversion efficiency while the <i>s</i>-polarized ones gave almost no signals. On the other hand, the polarizations of the SH signals were highly oriented in the direction of the <i>p</i>-polarizations. The SP-enhanced field attracts a lot of interests as light sources for sub-diffraction-limit imaging. The SP can be excited only in the regions lower than surface plasma frequencies peculiar to the metals. The present frequency conversion technologies for the SP enhanced fields in the NLO polymers will extend the frequency regions available for the sub-diffraction-limit imaging.