gebhart/patrepeval huggingface dataset:
Design and realization of a flexible finger actuated by shape memory alloy (SMA) wires (2017)

A flexible finger for robotic application composed by a variable number of autonomous modules was designed and realized. The motion of a single module is performed by SMA wires, capable of changes in their own length and causing the bending of the module. The heating of the wire, e.g. by means of Joule effect, causes the shortening of the wire itself, whereas the cooling, while a bias force is applied, causes the stretching of the wire to the original shape. The combination of different modules actuation could cause a complex deformation of the finger itself. A finite element model was studied and implemented in order to properly design the device. The preliminary tests on a first prototype demonstrate a good behaviour of the device.
Primary care physicians' knowledge of and experience with pharmacogenetic testing (2012)

It is anticipated that as the range of drugs for which pharmacogenetic testing becomes available expands, primary care physicians (PCPs) will become major users of these tests. To assess their training, familiarity, and attitudes toward pharmacogenetic testing in order to identify barriers to uptake that may be addressed at this early stage of test use, we conducted a national survey of a sample of PCPs. Respondents were mostly white (79%), based primarily in community-based primary care (81%) and almost evenly divided between family medicine and internal medicine. The majority of respondents had heard of PGx testing and anticipated that these tests are or would soon become a valuable tool to inform drug response. However, only a minority of respondents (13%) indicated they felt comfortable ordering PGx tests and almost a quarter reported not having any education about pharmacogenetics. Our results indicate that primary care practitioners envision a major role for themselves in the delivery of PGx testing but recognize their lack of adequate knowledge and experience about these tests. Development of effective tools for guiding PCPs in the use of PGx tests should be a high priority.
Harmonics generation from rod-type Yb doped fiber laser (2008)

We presents a compact diode pumped, Q-switched Yb doped rod-type fiber laser producing near diffraction limited frequency doubled and tripled beams with a conversion efficiency of respectively 62% and 38%.
YopT Is a Cysteine Protease Cleaving Rho Family GTPases (2006)

We have demonstrated that YopT recognizes the prenylated Rho GTPases (RhoA, Rac and Cdc42) in the host cell and executes a proteolytic cleavage at the C termini of the GTPases. This cleavage leads to the removal of the prenylated cysteine on the GTPases, which results in the membrane detachment of the GTPases. The model of YopT action is depicted in Figure 1. The proteolytic activity towards Rho GTPases described here is responsible for its known cytotoxicity. In addition, the proteolytic triad (C 139, H2598 and D274) is conserved in the entire YopT family of bacterial virulence factors, suggesting that the YopT defines a novel family of cysteine protease functioning in bacterial pathogenesis.
Wireless Sensor Network Testbed for Real-Time Sensor Monitoring (2009)

Due to the proliferation of technologies and services related with wireless sensor network, various sensor network applications are being appeared on the stage and a lot of sensor network testing technologies are being studied. However, most of testing systems or testbeds have objective for test and evaluation of sensor network protocols. For testing sensors and evaluating signal processing algorithms, it is necessary to develop a testbed for those purposes and especially, for monitoring the high speed sensing data. This paper proposes and implements a wireless sensor network testbed for controlling sensors, getting and managing the real-time sensing data on the remote sites.
Selecting stable molecular targets for treatment and prevention of AIDS. (2005)

The common consideration in approaching protection against HIV, whether by a vaccine or therapeutic, is identification of suitable targets. Among the central criteria for suitability is target stability; i.e. resistance to mutation. In this paper we address the problem of stability, and develop methods for identifying stable targets. The targets that we focus on are structures formed by viral peptides and products of the class I major histocompatibility complex, the target of the immune system. The method mines the large databases of fully sequenced HIV genomes and MHC binding peptides, and takes account of human polymorphism to construct hundreds of subpopulation specific stable targets, each consisting of combinations of 3-5 complexes.
Use of recombinant bovine alpha 1 interferon in reducing respiratory disease induced by bovine herpesvirus type 1 (1987)

Intranasal or intramuscular treatment of calves with recombinant bovine alpha 1 interferon before challenge with bovine herpesvirus type 1 and Pasteurella haemolytica reduced clinical signs, number of sick days, lung lesions, and weight loss. The effective dose was determined to be relatively broad within the range of 1 to 50 mg per animal. No adverse effects were observed even at high doses of interferon (50 mg per animal). Administration before virus infection was more effective than administration at the same time as virus infection. Although interferon administration had dramatic effects on the survival of animals, it did not have much effect on virus secretion in the upper respiratory tract. Therefore, the mechanism by which interferon reduces the susceptibility of animals to viral-bacterial synergy was postulated to be via its immunomodulatory effects.
Purification and characterization of canine myocardial cytosolic phospholipase A2. A calcium-independent phospholipase with absolute f1-2 regiospecificity for diradyl glycerophospholipids. (1990)

Recently, we identified a novel calcium-independent, plasmalogen-selective phospholipase A2 activity in canine myocardial cytosol which represents the major measurable phospholipase A2 activity in myocardial homogenates (Wolf, R. A., and Gross, R. W. (1985) J. Biol. Chem. 260, 7295-7303). We now report the 154,000-fold purification of this phospholipase A2 to homogeneity through utilization of sequential anion exchange, chromatofocusing, affinity, Mono Q, and hydroxylapatite chromatographies. The purified enzyme had a molecular mass of 40 kDa, possessed a specific activity of 227 mumol/mg min, had a pH optimum of 6.4, and catalyzed the regiospecific cleavage of the sn-2 fatty acid from diradyl glycerophospholipids. The purified polypeptide was remarkable for its ability to selectively hydrolyze plasmenylcholine in homogeneous vesicles (subclass rank order: plasmenylcholine greater than alkyl-ether choline glycerophospholipid greater than phosphatidylcholine) as well as in mixed bilayers comprised of equimolar plasmenylcholine/phosphatidylcholine. Purified myocardial phospholipase A2 also possessed selectivity for hydrolysis of phospholipids containing arachidonic acid at the sn-2 position in comparison to oleic or palmitic acid. Taken together, these results constitute the first purification of a calcium-independent phospholipase with absolute regiospecificity for cleavage of the sn-2 acyl linkage in diradyl glycerophospholipids and demonstrate that myocardial phospholipase A2 has kinetic characteristics which are anticipated to result in the selective hydrolysis of sarcolemmal phospholipids during myocardial ischemia.
Long-Period Hexagonal Structures in Melt-Spun Mg&lt;SUB&gt;97&lt;/SUB&gt;Ln&lt;SUB&gt;2&lt;/SUB&gt;Zn&lt;SUB&gt;1&lt;/SUB&gt; (Ln=Lanthanide Metal) Alloys (2003)

Novel long-period hexagonal structures with six and fourteen layered atomic configurations were formed in melt-spun Mg97Ln2Zn1 (Ln=Y, Gd and Sm) ternary alloys annealed at 573 K for 1.2-3.6 ks and in an as-spun Mg97Y2Zn1 alloy, respectively. The Mg-based alloys containing La or Ce as the Ln element have a mixed structure of hcp Mg and compound phases and no long-period hexagonal structure is formed in the as-spun and annealed states. There is a clear formation tendency of the novel long-period structure to increase with a decrease in the precipitation tendency of the intermetallic compound, an increase in the atomic size ratio of Ln/Mg and an enhancement of the formation tendency of Mg-based reinforced solid solution. The formation of the novel long-period structure is interpreted to result from the necessity of relaxation of strains caused by the reinforced solid solution of Ln and Zn elements into the Mg phase. In addition, the enrichment of Y and Zn elements was observed at the misfit sites of the atomic array in the fourteen layered hexagonal structure of the as-spun Mg97Y2Zn1 alloy. The atomic level segregation of Y and Zn elements is also thought to be the origin for the high stability of the long-period structure. The two types of long-period hexagonal structures found in the Mg-Ln-Zn alloys are important as a new mechanism for future development of high-strength Mg-based alloy.
Supplementary Figure 4 from Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors (2023)

&lt;p&gt;Supplementary figure 4 shows suppression of the PI3K pathway post a single dose of T-2143 in the LS174T xenograft model.&lt;/p&gt;
No “dose-dumping” with once-a-day Uniphyl (1986)

Clinical Pharmacology and Therapeutics (1986) 39, 598–598; doi:10.1038/clpt.1986.103
Dimeric Bridged and Chelated Alkali Metal (Li and Na) Bis(iminophosphorano)methanide Complexes with Contrasting Structures (2000)

Lithium (2) and sodium (3) complexes of deprotonated bis(iminophosphorano)methane, CH2(Ph2PNSiMe3)2, 1, differ in that the former is a C-bridged and the latter is an N-bridged dimer in the solid state.
Enhanced stability in spin transfer nanopillars due to a Fe/Gd/Fe trilayer (2013)

A sharp antiferromagnetic boundary of Fe/Gd is found to affect notoriously the critical current for spin transfer torque (STT). Transport measurements performed on nano-patterned spin valves show that when a Fe/Gd/Fe is added as a top layer, the effect of spin transfer on the free layer is dramatically reduced. The critical current increases up to one order of magnitude at 10 K and five times at room temperature. We show that this increase cannot be fully explained by the macrospin approximation and we argue that it is due to a torque at the Gd/Fe interface that opposes the STT in the free layer.
Folded and extended structures of homooligopeptides from .alpha.,.alpha.-dialkylated .alpha.-amino acids. An infrared absorption and proton nuclear magnetic resonance study (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFolded and extended structures of homooligopeptides from .alpha.,.alpha.-dialkylated .alpha.-amino acids. An infrared absorption and proton nuclear magnetic resonance studyGian Maria Bonora, Claudio Toniolo, Benedetto Di Blasio, Vincenzo Pavone, Carlo Pedone, Ettore Benedetti, Ian Lingham, and Paul HardyCite this: J. Am. Chem. Soc. 1984, 106, 26, 8152–8156Publication Date (Print):December 1, 1984Publication History Published online1 May 2002Published inissue 1 December 1984https://doi.org/10.1021/ja00338a025RIGHTS & PERMISSIONSArticle Views172Altmetric-Citations62LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (673 KB) Get e-Alerts Get e-Alerts
Probing the Atomic-Scale Mechanisms of Time-Dependent Dielectric Breakdown in Si/SiO<sub>2</sub> MOSFETs (June 2022) (2022)

We report on an atomic-scale study of trap generation in the initial/intermediate stages of time-dependent dielectric breakdown (TDDB) in high-field stressed (100) Si/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> MOSFETs using two powerful analytical techniques: electrically detected magnetic resonance (EDMR) and near-zero-field magnetoresistance (NZFMR). We find the dominant EDMR-sensitive traps generated throughout the majority of the TDDB process to be silicon dangling bonds at the (100) Si/SiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> interface ( <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${ \boldsymbol {P}}_{ \boldsymbol {b} \boldsymbol {0}}$ </tex-math></inline-formula> and <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">${ \boldsymbol {P}}_{ \boldsymbol {b} \boldsymbol {1}}$ </tex-math></inline-formula> centers) for both the spin-dependent recombination (SDR) and trap-assisted tunneling (SDTAT) processes. We find this generation to be linked to both changes in the calculated interface state densities as well as changes in the NZFMR spectra for recombination events at the interface, indicating a redistribution of mobile magnetic nuclei which we conclude could only be due to the redistribution of hydrogen at the interface. Additionally, we observe the generation of traps known as <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$\boldsymbol {E}'$ </tex-math></inline-formula> centers in EDMR measurements at lower experimental temperatures via SDR measurements at the interface. Our work strongly suggests the involvement of a rate-limiting step in the tunneling process between the silicon dangling bonds generated at the interface and the ones generated throughout the oxide.
Gravity-Off-loading System for Large-Displacement Ground Testing of Spacecraft Mechanisms (2010)

Gravity offloading of deployable spacecraft mechanisms during ground testing is a long-standing problem. Deployable structures which are usually too weak to support their own weight under gravity require a means of gravity offloading as they unfurl. Conventional solutions to this problem have been helium-filled balloons or mechanical pulley/counterweight systems. These approaches, however, suffer from the deleterious effects of added inertia or friction forces. The changing form factor of the deployable structure itself and the need to track the trajectory of the center of gravity also pose a challenge to these conventional technologies. This paper presents a novel testing apparatus for high-fidelity zero-gravity simulation for special application to deployable space structures such as solar arrays, magnetometer booms, and robotic arms in class 100,000 clean room environments.
Evaluation of an approximate method for incorporating floating docks in harbor wave prediction models (2005)

Computer models based on the two-dimensional (2-D) elliptic mild-slope equation are nowadays routinely used in harbor engineering applications. However, structures like floating breakwaters and docks, which are often encountered in the modeling domain, render the problem for locally three-dimensional model and hence are problematic to incorporate in a 2-D model. Tsay and Liu (Applied Ocean Research. 1983. Vol 5(1): 30–37) proposed a highly simplified but approximate approach that does not violate the overall two dimensionality of the problem. The validity of their approach is examined in detail, and it is found that although their approximation provides results with the correct trend, the actual solutions deviate considerably from the theoretical solutions. We have developed correction factors that may be used to produce more reliable results using the framework of Tsay and Liu. Application of the resulting method to a harbor in Alaska shows that docks in the harbor distort the wave field considerably and create a reflective pattern that has the potential to affect navigation safety in some areas. A by-product of this paper consists of plots of transmission coefficients for waves propagating past rectangular and cylindrical floating objects of infinite extent for a wide range of conditions encountered in practice. Such transmission coefficients are at present readily available in the published literature for selected cases only.Key words: wave, model, mild slope, equation, floating breakwater, dock, marina, harbor.
Genome analysis of the staphylococcal temperate phage DW2 and functional studies on the endolysin and tail hydrolase (2014)

This study describes the genome of temperate <i>Siphoviridae</i> phage DW2, which is routinely propagated on <i>Staphylococcus aureus</i> DPC5246. The 41941 bp genome revealed an open reading frame (ORF1) which has a high level of homology with members of the resolvase subfamily of site-specific serine recombinase, involved in chromosomal integration and excision. In contrast, the majority of staphylococcal phages reported to date encode tyrosine recombinases. Two putative genes encoded by phage DW2 (ORF15 and ORF24) were highly homologous to the NWMN0273 and NWMN0280 genes encoding virulence factors carried on the genome of ϕNM4, a prophage in the genome of <i>S. aureus</i> Newman. Phage DW2 also encodes proteins highly homologous to two well-characterized <i>Staphylococcus aureus</i> pathogenicity island derepressors encoded by the staphylococcal helper phage 80α indicating that it may similarly act as a helper phage for mobility of pathogenicity islands in <i>S. aureus</i>. This study also focused on the enzybiotic potential of phage DW2. The structure of the putative endolysin and tail hydrolase were investigated and used as the basis for a cloning strategy to create recombinant peptidoglycan hydrolyzing proteins. After overexpression in <i>E. coli,</i> four of these proteins (LysDW2, THDW2, CHAP<sub>E1-153</sub>, and CHAP<sub>E1-163</sub>) were demonstrated to have hydrolytic activity against peptidoglycan of <i>S. aureus</i> and thus represent novel candidates for exploitation as enzybiotics.
Abstract 350: Metabolism of Nitrite and Sulfide in the Aging Cardiovascular System (2014)

Introduction: Hydrogen Sulfide (H2S) and Nitric Oxide (NO) are gaseous signaling molecules that affect many pathophysiological functions like vasodilation, anti-inflammation, cytoprotection, anti-apoptosis, mitochondrial respiration and angiogenesis. These actions suggest that the relationship between these gasotransmitters could be involved in the cardiovascular aging response. Objective: We examined the age dependent regulation of H2S and NO metabolites in mice. Methods: Levels of H2S and NO metabolites were measured in various organs of C57BL/6J wild type mice at age 6, 12 and 24 weeks. The monobromobimane (MBB)-HPLC method was used to measure various sulfide pools. NO metabolites were measured using NO chemiluminescence. One-way ANOVA with bonferroni post-testing was used to compare metabolites between age groups. A p value of ≤ 0.05 was considered significant. Results: In the heart, lung and kidneys there was a significant increase in total and free sulfide levels with age over 24 weeks. In the heart, bound sulfide and acid labile sulfide remained stable with age. In the kidney, the bound sulfide increased with age and acid labile sulfide remained stable. In the lung, bound sulfide remained stable and acid labile sulfide remained stable with age. In the aorta and mesenteric artery, tissue total sulfide levels decreased with age. Lastly, the ratio between total H2S versus NO significantly increased with age in the heart and kidney. Conclusion: Our study reveals novel relationships between cardiovascular H2S and NO metabolism during aging. The increased H2S/NO ratio during aging may indicate important biochemical changes that affect cardiovascular pathogenesis.
Changes to the Editorial Board (2016)

It is my pleasure to welcome Prof. Lis K. Nanver to the Editorial Board of IEEE ELECTRON DEVICE LETTERS. A biography and sketch of Prof. Nanver’s research interests can be found below. Her subject areas are Silicon and Column IV Semiconductor Devices and Materials, Processing and Packaging.
The Role of F-Centers in Electron- and Photon-Stimulated Desorption from Alkali Halides (1987)

Measurements of the time history of ground state neutral lithium desorption from LiF during pulsed irradiation have resulted in a new model for lithium desorption.
Dehydrocyclization of Diphenylamine to Carbazole Over Platinum Catalysts (2008)

The gas-phase dehydrocyclization of diphenylamine (DPA) to carbazole over alumina-supported 0.4 wt.% Pt catalysts in a fix-bed reactor has been studied. The reaction was carried out at a temperature of 550 °C in the presence of hydrogen. All catalysts became well dispersed Pt after in situ reduction. Pt catalysts prepared in the presence of a competitive adsorbate (citric acid) were reasonably active during first hours on stream (DPA conversion higher than 90%). However, later, their activity decreased rapidly, except the catalyst prepared in the presence of a higher concentration of the competitive agent. The same trend was observed for the Pt catalyst prepared by wet impregnation. The activity of the catalysts prepared by a microemulsion technique was very high and stable during testing, the conversion of DPA being higher than 93%. However, the selectivities of catalysts prepared in the presence of citric acid gradually decreased with time on stream (TOS). The initial selectivityof such prepared catalysts for carbazole was about 60%. The same trend was observed for catalysts prepared by microemulsion technique. The highest selectivities, 73%, were obtained over the catalysts prepared by wet impregnation; it dropped after 6 days of testing to about 62%.
Characterization of extreme ultraviolet lithography mask defects by actinic inspection with broadband extreme ultraviolet illumination (2002)

We present our study on actinic detection of defects on extreme ultraviolet (EUV) lithography mask blanks with broadband EUV illumination from a synchrotron light source. A mirror blank was substituted for the monochromator grating in the synchrotron beamline. This increases the spectral bandwidth that is taken from the broadband synchrotron beam by 1 order of magnitude, leading to a commensurate increase in the total available flux. The detection sensitivity of this actinic inspection system is able to reach approximately 20 nm in equivalent defect size. This has been determined through cross correlation experiments done with commercial visible-light inspection tools. Experimental results also show that this broadband EUV inspection system has a capability of detecting phase defects with 5 nm surface height.
ChemInform Abstract: Synthesis of Substituted Cyclooctanols by a Samarium(II) Iodide Promoted 8‐Endo Radical Cyclization Process. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.