gebhart/patrepeval huggingface dataset:
The membrane‐associated progesterone‐binding protein 25‐Dx is expressed in brain regions involved in water homeostasis and is up‐regulated after traumatic brain injury (2005)

After traumatic brain injury, progesterone has important neuroprotective effects in the nervous system. There is better functional outcome and less oedema formation in pseudopregnant rat females (high levels of endogenous progesterone) than in males. In addition to intracellular progesterone receptors, membrane binding sites of the hormone such as 25-Dx may also be involved in neuroprotection. In the present study we investigated the distribution of the membrane-associated progesterone-binding protein 25-Dx in rat brain. Immunohistochemical analysis showed that 25-Dx is particularly abundant in the hypothalamic area, circumventricular organs, and ependymal cells of the lateral walls of the third and lateral ventricles. A strong signal was also detected in the meninges. Double immunofluorescence immunolabelling and confocal microscopy showed that 25-Dx is co-expressed with vasopressin in neurones of the paraventricular, supraoptic and retrochiasmatic nuclei. Levels of 25-Dx expression were higher in pseudopregnant females than in males. After traumatic brain injury, 25-Dx expression was up-regulated in neurones and induced in astrocytes, which play an important role in regulating water and ion homeostasis. The expression of 25-Dx in structures involved in CSF production (choroid plexus) and in osmoregulation (circumventricular organs, hypothalamus and meninges), and its up-regulation after brain damage, point to a novel and potentially important role of this progesterone-binding protein in the maintenance of water homeostasis after traumatic brain injury.
Biclonal lgM gammopathy in a lymphoproliferative disorder (1983)

An unusual case of an IgM producing lymphoproliferative disorder is presented. Using immunofluorescent techniques, this study shows that the heavy chain is associated with kappa light chain in some cells, and with lambda light chain in other cells. This indicates the presence of two distinct malignant cell populations in this patient.
Stereoselective One-pot Dialkylation of <i>gem</i>-Dihalocyclopropanes by Means of Dialkylcopperlithiums (1977)

Abstract The transformation of gem-dihalocyclopropanes (1) into 1-alkyl-1-butylcyclopropanes (2 and 3) is established by successive treatment with dibutylcopperlithium and several electrophiles. This sequence is found to be stereochemically controllable and is successfully applied to dl-sirenin synthesis. In contrast to the reaction of dibutylcopperlithium, dimethyl- and divinylcopperlithiums convert 1,1-dibromo-2-phenylcyclopropane (1a) into 1-bromo-1-methyl- and 1-bromo-1-vinyl-2-phenylcyclopropanes (15a, 16a and 15b, 16b) respectively.
RacGAP α2-Chimaerin Function in Development Adjusts Cognitive Ability in Adulthood (2014)

A major concern in neuroscience is how cognitive ability in adulthood is affected and regulated by developmental mechanisms. The molecular bases of cognitive development are not well understood. We provide evidence for the involvement of the α2 isoform of Rac-specific guanosine triphosphatase (GTPase)-activating protein (RacGAP) α-chimaerin (chimerin) in this process. We generated and analyzed mice with global and conditional knockouts of α-chimaerin and its isoforms (α1-chimaerin and α2-chimaerin) and found that α-chimaerin plays a wide variety of roles in brain function and that the roles of α1-chimaerin and α2-chimaerin are distinct. Deletion of α2-chimaerin, but not α1-chimaerin, beginning during early development results in an increase in contextual fear learning in adult mice, whereas learning is not altered when α2-chimaerin is deleted only in adulthood. Our findings suggest that α2-chimaerin acts during development to establish normal cognitive ability in adulthood.
A study of the oxepane synthesis by a 7-endo electrophile-induced cyclization reaction of alkenylsulfides. An approach towards the synthesis of septanosides (2006)

A procedure for the stereoselective synthesis of 2-deoxy-2-iodo-septanosides from pyranoses is reported. The procedure involves two reactions: Wittig-Horner olefination to give alkenyl sulfanyl derivatives, and electrophilic iodine-induced cyclization to give phenyl 2-deoxy-2-iodo-1-thio-septanosides (20) or 2-deoxy-2-iodo-septanosides (26a,b), in this case by subsequent hydrolysis of a phenylsulfanyl group under the reaction conditions. The seven membered ring of septanosides was only formed in moderate to low yields, preferably through a 7-endo cyclization, when an isopropylidene group was present as protecting group. The use of benzyl groups as protecting moieties in the pyranose does not afford the septanoside ring. However, when the reactions conditions were forced using more basic media, the furanoside derivatives 3 were obtained.
A compact optically pumped semiconductor laser emitting at 593 nm (2011)

We achieved 100mW cw of 593nm by intracavity sum frequency generation in a branched cavity, dual laser set up. Two gain media were used: Nd:YVO4 for generating 1342nm, diode-pumped by 3.7W at 808nm, and an optically pumped semiconductor chip (OPS), designed for 1064nm emission, diode-pumped by 1.7W at 808nm. Due to the short upperstate lifetime of the OPS, the generated 593nm output power was stable.A
Enhanced Thermoelectric Metrics in Ultra-long Electrodeposited PEDOT Nanowires (2011)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionEnhanced Thermoelectric Metrics in Ultra-long Electrodeposited PEDOT NanowiresDavid K. Taggart, Yongan Yang, Sheng-Chin Kung, Theresa M. McIntire, and Reginald M. Penner*Cite this: Nano Lett. 2011, 11, 5, 2192–2193Publication Date (Web):April 14, 2011Publication History Published online14 April 2011Published inissue 11 May 2011https://pubs.acs.org/doi/10.1021/nl201142jhttps://doi.org/10.1021/nl201142jcorrectionACS PublicationsCopyright © 2011 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1332Altmetric-Citations10LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (632 KB) Get e-Alertsclose Get e-Alerts
Polarization switching approach to the suppression of polarization-induced signal fading in fiber optic sensor array (1994)

Signals from fiber-optic interferometric sensors fabricated with conventional communication fibers may be lost due to the random fluctuation of the polarization states of two interfering optical waves.
Radiation Simulation of a Microgravity Diffusion Flame (1996)

Abstract This study numerically investigates the effects of radiation from both the soot and gas phase species on the soot kinetics in a quasi-steady state microgravity spherical acetylene-air diffusion flame by coupling the soot and gas phase chemistry with radiative heat transfer processes. The gas phase reaction is modeled by two step chemical kinetics. The soot reaction mechanism includes nucleation, surface growth, oxidation and coagulation steps. The radiation from both soot and the gas phase are calculated by employing a spherical harmonics (P-1 approximation) model. The local Planck mean absorption coefficients of the computed species are specified in the computations. Unlike normal gravity acetylene-air steady state jet diffusion flames in which the radiation from soot dominates gas radiation effects, it is found that for a microgravity diffusion flame, except at very early times, the radiation from the gas products dominates soot radiation. In the microgravity flame configuration, it is noted that the radiation heat loss fraction (defined as the ratio of the radiation heat loss rate to the chemical heat release rate) increases up to 80% shortly after ignition.
Management of persistent gastric bleeding in a patient with Glanzmann's thrombasthenia (2008)

presentation and evolution of a real clinical case, reacting to clinical information and data (boldface type).
Evaluation of a Direct‐Coupled Time‐Domain Reflectometry for Determination of Soil Water Content and Bulk Electrical Conductivity (2016)

Core Ideas TDR‐315 sensors could be calibrated using conventional TDR methodologies. Soil water content calibrations using conventional TDR and TDR‐315 were comparable. Measured travel time using TDR‐315 was insensitive to soil electrical conductivity. Signal degradation in coaxial cables and interconnects is a long‐standing problem in the practical deployment of time‐domain reflectometry (TDR) for soil water monitoring. Acclima, Inc. has recently commercialized a TDR sensor (TDR‐315) with all electronics required for waveform acquisition embedded in the probe head. We calibrated ten TDR‐315 sensors and conventional TDR for apparent permittivity ( K a ) and bulk electrical conductivity (σ a ) measurements. Also, soil water content calibrations were completed for a Pullman (fine, mixed, superactive, thermic torrertic Paleustolls) clay loam soil. Lastly, the sensitivity of K a to σ a was examined using a saturated solute displacement experiment with both probe technologies installed in a column packed with Pullman clay loam. A range of σ a (0.65–2.8 dS m −1 ) was established by equilibrating the column with 0.25 dS m −1 CaCl 2 and introducing a step pulse of 7.3 dS m −1 CaCl 2 . Permittivity calibrations of the TDR‐315 could be accomplished with conventional TDR methods and with similar sampling errors. Conventional calibrations of σ a using long time amplitudes yielded a linear response for σ a ≤ 3 dS m −1 , above which the response was nonlinear. The fitted water content calibrations of the Pullman clay loam for the TDR‐315 were nearly indistinguishable from conventional TDR calibrations with similar root mean square errors (0.017–0.020 m 3 m −3 ). Response of the two measurement technologies in a lossy soil during changing solution conductivities demonstrated that, in contrast to conventional TDR, travel time measured using acquired TDR‐315 waveforms was insensitive to σ a up to 2.8 dS m −1 .
Femtosecond laser‐induced micro‐explosions with high aspect ratio in transparent materials (2016)

International audience
Lentiform Nucleus Hyperechogenicity in Parkinsonian Syndromes: A Systematic Review and Meta-Analysis with Consideration of Molecular Pathology (2019)

The hyperechogenicity of the substania nigra (SN) has been established as a valid finding in patients with Parkinson´s disease (PD), probably caused by an increased tissue iron concentration in the SN. The application of transcranial sonography (TCS) has been investigated for further echogenic basal ganglia alterations in patients with extrapyramidal movement disorders. Compared to PD, a hyperechogenic nucleus lentiformis (LN) has been reported to appear more frequently in atypical parkinsonian syndromes (aPS) such as the parkinsonian phenotype of multiple system atrophy (MSA-P) or the progressive supranuclear palsy (PSP). As the evidence providing study sizes are small, we conduct the first meta-analysis of the prevalence of LN hyperechogenicity in PD and aPS. We search for available studies providing prevalence of LN hyperechogenicity in patients with PD and aPS (MSA-P and PSP) detected by TCS in MEDLINE and SCOPUS databases. We calculate the prevalence rates of LN hyperechogenicity detection in patients with clinical diagnosis of PD vs. aPS under the random-effects model. We include a total of 1330 patients, 1091 PD and 239 aPS (MSA-P and PSP). We find a significantly higher prevalence of LN hyperechogenicity in aPS (76%, 95% CI: 0.62-0.88) compared to PD (16%, 95% CI: 0.10-0.23). After proving a higher prevalence of LN hyperechogenicity in aPS compared to PD, its histopathological cause needs to be investigated. Furthermore, its full diagnostic accuracy and the qualification to serve as a risk factor for MSA-P and PSP should also be questioned in future studies.
Microscopic Deformation Analysis of PC Connector Endfaces using Multicore Fiber (2017)

Stable physical contact (PC) connection is realized by elastically deformed spherical convex polished ferrule ends. However, microscopic deformation of the ferrule endface was not clarified yet. We analyzed ferrule endface deformation by FEM and return loss measurement of multicore fiber connectors.
Clofarabine Can Replace Anthracyclines and Etoposide in Remission Induction Therapy for Childhood Acute Myeloid Leukemia: The AML08 Multicenter, Randomized Phase III Trial (2019)

Our findings suggest that the use of clofarabine with cytarabine during remission induction might reduce the need for anthracycline and etoposide in pediatric patients with acute myeloid leukemia and may reduce rates of cardiomyopathy and treatment-related cancer.
Common media client data (CMCD) (2021)

In September 2020, the Consumer Technology Association (CTA) published the CTA-5004: Common Media Client Data (CMCD) specification. Using this specification, a media client can convey certain information to the content delivery network servers with object requests. This information is useful in log association/analysis, quality of service/experience monitoring and delivery enhancements. This paper is the first step toward investigating the feasibility of CMCD in addressing one of the most common problems in the streaming domain: efficient use of shared bandwidth by multiple clients. To that effect, we implemented CMCD functions on an HTTP server and built a proof-of-concept system with CMCD-aware dash.js clients. We show that even a basic bandwidth allocation scheme enabled by CMCD reduces rebuffering rate and duration without noticeably sacrificing the video quality.
Structural characterization and hydrolytic degradation of a Zn metal initiated copolymer of L-lactide and ε-caprolactone (1997)

A bioresorbable aliphatic polyester was synthesized by bulk copolymerization of a 1/1 M/M L,L-lactide/epsilon-caprolactone mixture using zinc metal as initiator. The actual composition of the copolymer was found to be 1.5/1 as deduced from 1H NMR spectra obtained in DMSO-d6 solutions where higher resolution was obtained as compared with chlorinated solvents. Resonances due to L-lactyl units (L) exhibited triads stereosensitivity, epsilon-oxycaproyl units (C) being sensitive to dyads. Average lengths of both poly(lactic acid) and polycaprolactone sequences were evaluated and showed the presence of rather long PLA blocks. Furthermore, no CLC triad signal was found, suggesting the absence of transesterification rearrangements. 10 x 10 x 2 mm specimens made of the copolymer were allowed to age in isoosmolar pH = 7.4 phosphate buffer at 37 degrees C. Degradation was monitored by various analytical techniques such as SEC, X-ray diffractometry, DSC, and 1H NMR. Data were compared with the behaviour of PCL and PLA homopolymers allowed to age under similar conditions. Crystallinity and composition changes are discussed in terms of preferential degradation in L- and C-containing amorphous domains, crystallized long PLA blocks being much more resistant.
Grating-Coupled Surface-Plasmon-Resonance Biosensor Discs with a C-Type Fluidic Channel for Monitoring Growth of Self-Assembled Monolayer (2013)

In this paper, we present a grating-coupled surface plasmon resonance (SPR) biosensor with a c-type fluidic channel on a grating disc. For obtaining the kinetic information of molecular interaction, we combined a c-type fluidic channel on disc to drive testing solution forward by gravity via turning the grating disc. The disc biosensor can react with probe molecules on the different sensing surfaces in the following time. The repeatability testing shows the resolution of angle of the measuring system was enhanced by threefold comparing to that without the automation improvement. In order to identify the accuracy of angle changes of SPR due to the chemical reaction on surface, experiment for monitoring a growth self-assembled monolayer (SAM) immobilized on gold surface was performed. The measured response curves show that the saturation time of the SAM formation, which thickness is smaller than 2 nm, is roughly 5 hours when 1 mM MHDA growing on gold at room temperature. The demonstration reveals that the disc biosensor with c-type fluidic channels can be a promising tool for a kinetic analysis of bimolecular interaction without any external fluid pumping systems.
Compton imaging tomography for nondestructive evaluation of spacecraft thermal protection systems (2017)

Here we present new results of in situ nondestructive evaluation (NDE) of spacecraft thermal protection system materials obtained with POC-developed NDE tool based on a novel Compton Imaging Tomography (CIT) technique recently pioneered and patented by Physical Optics Corporation (POC). In general, CIT provides high-resolution three-dimensional Compton scattered X-ray imaging of the internal structure of evaluated objects, using a set of acquired two-dimensional Compton scattered X-ray images of consecutive cross sections of these objects. Unlike conventional computed tomography, CIT requires only one-sided access to objects, has no limitation on the dimensions and geometry of the objects, and can be applied to large multilayer non-uniform objects with complicated geometries. Also, CIT does not require any contact with the objects being imaged during its application.
Pathogenicity of a natural reassortant hantavirus CGRn9415 in newborn rats and newborn mice (2012)

To better understand the pathogenicity and infectivity of a natural reassortant CGRn9415 generated from Hantaan virus (HTNV) and Seoul virus (SEOV), CGRn9415, HTNV 76-118 and SEOV L99 were used to infect newborn Kunming (KM) mice and newborn Wistar rats. In KM mice, there was no statistical difference between the death rate with CGRn9415 and that of L99, while 76-118 killed all mice even at low dosage; CGRn9415 killed all infected rats similar to L99 at the dosage of 10(5) f.f.u., while no death occurred in rats infected with 76-118 even as high as 2 × 10(5) f.f.u., suggesting that the reassortant CGRn9415 possesses similar pathogenicity as L99. Furthermore, the reassortant CGRn9415 could establish a persistent infection in both KM mice and Wistar rats more easily than 76-118 or L99. These data suggest that the reassorted hantavirus behaves more like SEOV as far as the pathogenicity is concerned.
An approach to modeling clock tree of a complex system-on-chip (2016)

Clock tree of a complex system-on-chip is modeled across different design stages independently, resulting in multiplication of time and effort needed to develop clock tree models. Model-based design is an emerging methodology that can improve the efficiency, time, and cost of a system design. We propose an approach to modeling clock tree of a complex system-on-chip by exploiting patterns in hardware architectures. Based on patterns, we create parametrized models of clocks which are represented in the form of a template. The specification of a clock consists of specifying parameter values for the template model. The modeling approach is used to generate clock tree models for a variety of design activities including system-level models for power management design.
MATRIX16: A 16-Channel Low-Power TDC ASIC with 8 ps Time Resolution (2021)

This paper presents a highly configurable 16-channel TDC ASIC designed in a commercial 180 nm technology with the following features: time-of-flight and time-over-threshold measurements, 8.6 ps LSB, 7.7 ps jitter, 5.6 ps linearity error, up to 5 MHz of sustained input rate per channel, 9.1 mW of power consumption per channel, and an area of 4.57 mm2. The main contributions of this work are the novel design of the clock interpolation circuitry based on a resistive interpolation mesh circuit and the capability to operate at different supply voltages and operating frequencies, thus providing a compromise between TDC resolution and power consumption.
Lapatinib access into normal brain and brain metastases in patients with Her-2 overexpressing breast cancer (2015)

ClinicalTrials.gov: NCT01290354.
Reconnaissance field report for the search of large telescope sites in the sierra San Pedro Mártir, Baja California, México (2007)

La Sierra San Pedro Mártir en el estado de Baja California, México, es conocida por sus excelentes condiciones para la observación astronómica. Ofrece una serie de sitios con elevaciones que rebasan los 2650 m, potencialmente apropiados para la instalación de futuros grandes telescopios. Algunos de estos sitios son remotos y es necesario determinar sus rutas de acceso para efectuar mediciones de evaluación de las condiciones para la observación astronómica. Durante el verano de 2005 se visitaron seis sitios que pueden ser adecuados para la instalación de telescopios e instrumentos de medición de la calidad del cielo, para determinar sus coordenadas asÍ como sus posibles rutas de acceso. En este trabajo se presenta una breve descripción de cada uno de estos sitios
Adaptive secondary mirror development for the UH-88 telescope: (2019)

TNO and industrial partners VDL ETG, L3Harris and Hyperion are developing a novel Adaptive Secondary Mirror (ASM) for Ground Layer Adaptive Optics (GLAO) at the University of Hawaii’s 88-inch telescope on Mauna Kea. The ASM is based on a unique actuator principle which delivers a &gt;30µm PV 99% linear stroke at a very high efficiency in terms of force per unit of volume and of power. The adaptive mirror does not require active cooling and due to its compactness can be fitted within the same volume of the original passive mirror. The overall dimensions of the ASM for the UH88 are ø63cm with 204 actuators in a circular grid and an overall height of 13cm. The ULE mirror shell has an aspherical convex shape with a 4,2-meter radius of curvature and a thickness of 3,5mm. At the time of writing of this paper the project is in the critical design phase with installation on the telescope anticipated late 2020.