gebhart/patrepeval huggingface dataset:
Resistance Training for Pediatric Female Dancers (2016)

Resistance training often is not an inherent component of current dance training for pediatric female dancers. Reasons for this include concerns surrounding injury to the immature skeleton and diminishing dancer aesthetic appearance, as well as questions related to the effectiveness of such training for increasing dancer strength and muscle endurance. Many forms of dance demand sufficient muscle strength and endurance for prolonged periods of high intensity dance, power generation during leaps and jumps, as well as stabilization of the lower extremity to prevent injury. The benefits of resistance training for the pediatric female dancer are multiple, including improved muscle strength and bone health and decreased risk for stress related injuries to the actively growing skeleton. Understanding the biomechanical changes that occur during growth that may predispose the female dancer to injury is important, as well as initiating individualized resistance training protocols early in training that may serve to improve performance and prevent future injury.
Bcl-2 family-regulated apoptosis in health and disease (2010)

Bcl-2 family-regulated apoptosis in health and disease Grant Dewson, Ruth M KluckMolecular Genetics of Cancer Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, AustraliaAbstract: Apoptotic cell death is essential for embryonic development, tissue homeostasis, and a well-functioning immune system, with aberrant apoptosis contributing to numerous disease conditions. Inadequate cell death is a major contributing factor to tumorigenesis, while excess cell death contributes to neurodegeneration and autoimmune disease. The major pathway of apoptotic cell death, the mitochondrial pathway, is controlled by the Bcl-2 family of proteins. The members of this family, more than 17 in humans, share significant sequence and structural homology, and fulfil either prosurvival or proapoptotic roles. Specific interactions between these functionally polar proteins, and their relative expression levels, govern the susceptibility of each cell to toxic insults. Here we review the current understanding on how apoptotic cell death is controlled by this important protein family. We also discuss how excessive or insufficient cell death can contribute to disease, and how targeting the Bcl-2 family offers novel therapeutic opportunities.Keywords: apoptosis, Bcl-2, cancer, cytochrome c, mitochondria
Replication‐coupled histone H3.1 deposition determines nucleosome composition and heterochromatin dynamics during Arabidopsis seedling development (2018)

Developmental phase transitions are often characterized by changes in the chromatin landscape and heterochromatin reorganization. In Arabidopsis, clustering of repetitive heterochromatic loci into so-called chromocenters is an important determinant of chromosome organization in nuclear space. Here, we investigated the molecular mechanisms involved in chromocenter formation during the switch from a heterotrophic to a photosynthetically competent state during early seedling development. We characterized the spatial organization and chromatin features at centromeric and pericentromeric repeats and identified mutant contexts with impaired chromocenter formation. We find that clustering of repetitive DNA loci into chromocenters takes place in a precise temporal window and results in reinforced transcriptional repression. Although repetitive sequences are enriched in H3K9me2 and linker histone H1 before repeat clustering, chromocenter formation involves increasing enrichment in H3.1 as well as H2A.W histone variants, hallmarks of heterochromatin. These processes are severely affected in mutants impaired in replication-coupled histone assembly mediated by CHROMATIN ASSEMBLY FACTOR 1 (CAF-1). We further reveal that histone deposition by CAF-1 is required for efficient H3K9me2 enrichment at repetitive sequences during chromocenter formation. Taken together, we show that chromocenter assembly during post-germination development requires dynamic changes in nucleosome composition and histone post-translational modifications orchestrated by the replication-coupled H3.1 deposition machinery.
The influence of rare variants in circulating metabolic biomarkers (2020)

Circulating metabolite levels are biomarkers for cardiovascular disease (CVD). Here we studied, association of rare variants and 226 serum lipoproteins, lipids and amino acids in 7,142 (discovery plus follow-up) healthy participants. We leveraged the information from multiple metabolite measurements on the same participants to improve discovery in rare variant association analyses for gene-based and gene-set tests by incorporating correlated metabolites as covariates in the validation stage. Gene-based analysis corrected for the effective number of tests performed, confirmed established associations at APOB, APOC3, PAH, HAL and PCSK (p<1.32x10-7) and identified novel gene-trait associations at a lower stringency threshold with ACSL1, MYCN, FBXO36 and B4GALNT3 (p<2.5x10-6). Regulation of the pyruvate dehydrogenase (PDH) complex was associated for the first time, in gene-set analyses also corrected for effective number of tests, with IDL and LDL parameters, as well as circulating cholesterol (pMETASKAT<2.41x10-6). In conclusion, using an approach that leverages metabolite measurements obtained in the same participants, we identified novel loci and pathways involved in the regulation of these important metabolic biomarkers. As large-scale biobanks continue to amass sequencing and phenotypic information, analytical approaches such as ours will be useful to fully exploit the copious amounts of biological data generated in these efforts.
Experiência de utilização de XML no SMS. (2011)

XML e sua utilização em aplicações de bioinformática. Utilização de XML no módulo JPD do SMS. Discussão e trabalhos futuros.
Genomic Characterization of Upper-Tract Urothelial Carcinoma in Patients With Lynch Syndrome (2018)

LSand sporadic UTUCs have overlapping but distinct genetic signatures. LS-UTUC is associated with hypermutation and a significantly higher prevalence of <i>FGFR3</i> R248C mutation. Prospective molecular characterization of patients to identify those with LS-UTUC may help guide treatment.
Passive Smart Materials for Sensing and Actuation (1993)

Materials containing various types of hollow porous fibers filled with a chemical that is released into the matrix at appropriate times, or over time, are designed to address some issues of material performance, namely, cracking, corrosion, en ergy absorption and change in dynamic modulus (Dry, 1991a, 1991b).
Anion Reactions of 1,3-Dithiane 1,3-Dioxide with Carbonyl Compounds: High Diastereoselectivity with Aromatic Aldehydes under Conditions of Equilibrium Control (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnion Reactions of 1,3-Dithiane 1,3-Dioxide with Carbonyl Compounds: High Diastereoselectivity with Aromatic Aldehydes under Conditions of Equilibrium ControlVarinder K. Aggarwal, Richard Franklin, John Maddock, Graham R. Evans, Abraham Thomas, Mary F. Mahon, Kieran C. Molloy, and Martin J. RiceCite this: J. Org. Chem. 1995, 60, 7, 2174–2182Publication Date (Print):April 1, 1995Publication History Published online1 May 2002Published inissue 1 April 1995https://doi.org/10.1021/jo00112a042Request reuse permissionsArticle Views339Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (2 MB) Get e-Alertsclose Get e-Alerts
Dupo: A Mixed-Initiative Authoring Tool for Responsive Visualization (2023)

Designing responsive visualizations for various screen types can be tedious as authors must manage multiple chart~versions across design iterations. Automated approaches for responsive visualization must take into account the user's need for agency in exploring possible design ideas and applying customizations based on their own goals. We design and implement Dupo, a mixed-initiative approach to creating responsive visualizations that combines the agency afforded by a manual interface with automation provided by a recommender system. Given an initial design, users can browse automated design suggestions for a different screen type and make edits to a chosen design, thereby supporting quick prototyping and customizability. Dupo employs a two-step recommender pipeline that first suggests significant design changes (Exploration) followed by more subtle changes (Alteration). We evaluated Dupo with six expert responsive visualization authors. While creating responsive versions of a source design in Dupo, participants could reason about different design suggestions without having to manually prototype them, and thus avoid prematurely fixating on a particular design. This process led participants to create designs that they were satisfied with but which they had previously overlooked.
Correction to “A New Interleukin-13 Amino-Coated Gadolinium Metallofullerene Nanoparticle for Targeted MRI Detection of Glioblastoma Tumor Cells” (2016)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to "A New Interleukin-13 Amino-Coated Gadolinium Metallofullerene Nanoparticle for Targeted MRI Detection of Glioblastoma Tumor Cells"Tinghui Li, Susan Murphy, Boris Kiselev, Kanwarpal S. Bakshi, Jianyuan Zhang, Amnah Eltahir, Yafen Zhang, Ying Chen, Jie Zhu, Richey M. Davis, Louis A. Madsen, John R. Morris, Daniel R. Karolyi, Stephen M. LaConte, Zhi Sheng*, and Harry C. Dorn*Cite this: J. Am. Chem. Soc. 2016, 138, 5, 1723Publication Date (Web):January 28, 2016Publication History Published online28 January 2016Published inissue 10 February 2016https://pubs.acs.org/doi/10.1021/jacs.6b00117https://doi.org/10.1021/jacs.6b00117correctionACS PublicationsCopyright © 2016 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1146Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (124 KB) Get e-Alertsclose Get e-Alerts
Label-free Detection of Lymph Node Metastases with US-guided Functional Photoacoustic Imaging (2015)

The results show that US-guided sPA imaging is capable of depicting changes in SO2 in lymph nodes that were correlated with metastatic invasion.
Big Data Quality for Data Mining in Business Intelligence Applications (2020)

Study of data quality for data mining application has always been a complex topic; in the recent years, this topic has gained further complexity with the advent of big data as the source for data mining and business intelligence (BI) applications. In a big data environment, data is consumed in various states and various forms serving as input for data mining, and this is the main source of added complexity. These new complexities and challenges arise from the underlying dimensions of big data (volume, variety, velocity, and value) together with the ability to consume data at various stages of transition from raw data to standardized datasets. These have created a need for expanding the traditional data quality (DQ) factors into BDQ (big data quality) factors besides the need for new BDQ assessment and measurement frameworks for data mining and BI applications. However, very limited advancement has been made in research and industry in the topic of BDQ and their relevance and criticality for data mining and BI applications. Data quality in data mining refers to the quality of the patterns or results of the models built using mining algorithms. DQ for data mining in business intelligence applications should be aligned with the objectives of the BI application. Objective measures, training/modeling approaches, and subjective measures are three major approaches that exist to measure DQ for data mining. However, there is no agreement yet on definitions or measurements or interpretations of DQ for data mining. Defining the factors of DQ for data mining and their measurement for a BI system has been one of the major challenges for researchers as well as practitioners. This chapter provides an overview of existing research in the area of BDQ definitions and measurement for data mining for BI, analyzes the gaps therein, and provides a direction for future research and practice in this area.
Recent developments in cell-based assays and stem cell technologies for botulinum neurotoxin research and drug discovery (2014)

Botulinum neurotoxins (BoNTs) are exceptionally potent inhibitors of neurotransmission, causing muscle paralysis and respiratory failure associated with the disease botulism. Currently, no drugs are available to counter intracellular BoNT poisoning. To develop effective medical treatments, cell-based assays provide a valuable system to identify novel inhibitors in a time- and cost-efficient manner. Consequently, cell-based systems including immortalized cells, primary neurons and stem cell-derived neurons have been established. Stem cell-derived neurons are highly sensitive to BoNT intoxication and represent an ideal model to study the biological effects of BoNTs. Robust immunoassays are used to quantify BoNT activity and play a central role during inhibitor screening. In this review, we examine recent progress in physiologically relevant cell-based assays and high-throughput screening approaches for the identification of both direct and indirect BoNT inhibitors.
Dual radio frequency sources in a magnetized capacitively coupled plasma discharge (2003)

Nonlinear interaction of two radio frequency (RF) sources in a magnetized Ar/C/sub 2/F/sub 6/ capacitively coupled plasma discharge is investigated using a computational model. Results show that application of a radial magnetic field enhances charged and neutral species densities in the plasma reactor due to reduction in electron loss to surfaces and trapping of secondary electron emission generated electrons. Amplitude of RF currents at electrodes also increases with magnetic field strength and source frequency for a given RF voltage. Due to nonlinear nature of plasma sheath, higher harmonics of applied frequencies and source interaction generated harmonics can be observed in electrode currents. Application of magnetic field decreases electron mobility and makes the system less nonlinear, which reduces higher harmonics relative to primary components. Magnetic field also tends to make the RF sources more isolated. Increase in source frequency moves the plasma from electrode edge to the center of the chamber, which redistributes current through the electrodes. If frequencies of the two RF sources are commensurate, nonlinear interaction of RF sources generates subharmonics of primary frequencies.
Conversion of Primary Amides to Nitriles by Aldehyde-Catalyzed Water Transfer (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTConversion of Primary Amides to Nitriles by Aldehyde-Catalyzed Water TransferMarie-Pierre Heck, Alain Wagner, and Charles MioskowskiView Author Information CEA, CE-Saclay, Service des Molécules Marquées, Bât 547, Département de Biologie Cellulaire et Moléculaire, F-91191 Gif Sur Yvette, France, and Université Louis Pasteur, Laboratoire de Synthèse Bio-Organique associé au CNRS, Faculté de Pharmacie, 74 route du Rhin BP 24, F-67401 Illkirch, France Cite this: J. Org. Chem. 1996, 61, 19, 6486–6487Publication Date (Web):September 20, 1996Publication History Received17 June 1996Revised1 August 1996Published online20 September 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/jo961128vhttps://doi.org/10.1021/jo961128vrapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views2485Altmetric-Citations40LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Aldehydes,Amides,Chemical reactions,Dehydration,Nitrogen compounds Get e-Alerts
End-to-End Simultaneous Translation System for IWSLT2020 Using Modality Agnostic Meta-Learning (2020)

In this paper, we describe end-to-end simultaneous speech-to-text and text-to-text translation systems submitted to IWSLT2020 online translation challenge. The systems are built by adding wait-k and meta-learning approaches to the Transformer architecture. The systems are evaluated on different latency regimes. The simultaneous text-to-text translation achieved a BLEU score of 26.38 compared to the competition baseline score of 14.17 on the low latency regime (Average latency 3). The simultaneous speech-to-text system improves the BLEU score by 7.7 points over the competition baseline for the low latency regime (Average Latency 1000).
Glossary of Economics Concepts (2001)

Economists use the term effect to describe the benefit a consumer enjoys as a result of others' using the same product or service. The history of videocassettes offers a striking example of the power of bandwagon effects. Originally there were two technical standards for videocassettes in the United States: Beta and VHS. Beta was widely regarded to have better picture quality, but VHS could record longer television programs. Eventually the selection of Beta cassettes shrank to zero, leaving consumers no choice but to get on the VHS bandwagon. The most successful bandwagon, apart from telephone service, is the Internet.In this book Jeffrey Rohlfs shows how the dynamics of bandwagons differ from those of conventional products and services. They are difficult to get started and often fail before getting under way. A classic example of a marketing failure is the Picturephone, introduced by the Bell System in the early 1970s. Rohlfs describes the fierce battles waged by competitors when new services are introduced, as well as cases of early agreement on a single technical standard, as with CDs and CD players. He also discusses the debate among economists and policy analysts over the advantages and disadvantages of having governments set technical standards. The case studies include fax machines, telephones, CD players, VCRs, personal computers, television, and the Internet.
Bone marrow characterization in the lumbar spine with inner volume spectroscopic CPMG imaging studies (1994)

The authors describe new magnetic resonance (MR) spectroscopic and postprocessing methods for characterizing major proton peaks and their spectral T2 values in many small voxels throughout extensive regions of bone marrow within the adult lumbar spine. The techniques are based on spectroscopic interrogation of 128 voxels along columns oriented through the spine at eight TE values. Mean fat content measurements, based on quantification of the proton peaks of water and saturated fat (-CH2-)n, corrected for T2 decay, ranged from 40% to 60%. The mean T2 value of the lipid peak, 113 msec +/- 21, was significantly longer (P < .001) than that of water (71 msec +/- 14). The techniques combine features of MR spectroscopy and imaging most suited for spatially efficient coverage of bone marrow at spectral resolutions sufficient for intra-voxel fat or water content measurements. The methods introduced provide a practical, quantitative means for characterizing vertebral marrow in diseases affecting marrow cellularity.
Multiplex Real-Time Reverse Transcription–Polymerase Chain Reaction for the Detection of Three Viruses Associated with Poult Enteritis Complex: Turkey Astrovirus, Turkey Coronavirus, and Turkey Reovirus (2005)

Poult enteritis complex (PEC) is an economically important disease of young turkeys characterized by diarrhea, poor weight gain, and, in some cases, high mortality. Although PEC is considered to be a polymicrobial disease, numerous viruses, including turkey coronavirus (TCV), turkey astrovirus type 2 (TAstV-2), and avian reoviruses (ARVs), have been associated with PEC-like disease. Real-time reverse transcription-polymerase chain reaction (RRT-PCR), a highly sensitive and specific detection method for viral RNA, was developed in a multiplex format for the simultaneous detection of TAstV-2 and TCV and for the detection of two genetic types of ARV. Assay sensitivity was determined using in vitro transcribed RNA and varied by target between 150 gene copies for TAstV-2 alone and 2200 gene copies for TCV when multiplexed. Virus detection was evaluated with samples collected from poults inoculated at 1 day of age with each of the viruses. Cloacal swabs and intestinal samples were obtained at 1, 2, 3, 4, 6, 9, 14, 17, and 21 days after inoculation, processed, and tested for virus detection by RRT-PCR Cloacal swabs from TAstV-2- and TCV-infected poults were shown to have sensitivity for virus detection similar to that of intestinal samples when compared directly. ARV detection by RRT-PCR was compared with virus isolation and had similar sensitivity.