gebhart/patrepeval huggingface dataset:
Die-hard survivors: heterogeneity in apoptotic thresholds may underlie chemoresistance (2015)

The unmatched efficacy of microtubule-targeting agents (MTAs) as chemotherapeutics was once assumed to originate from their impact on mitotic processes; however, this misconception is being eroded by amassing data that MTAs instead target interphase functions in patients' tumors. What remains murky is how MTAs target malignant cells over non-malignant ones if proliferation rates do not distinguish them. In many instances, malignant cells are actually more 'primed' for apoptosis than non-malignant ones. Nevertheless, even if most cells within the tumor are more apoptosis-susceptible than those in healthy tissues, there likely exist small subpopulations of apoptosis-resistant clones that engender incomplete responses to MTAs and relapse. Therefore, intratumor heterogeneity in terms of proximity to the apoptotic threshold must be better understood to facilitate the design of chemotherapeutic regimens, which may benefit from including drugs like BH3 mimetics that help in lowering the apoptotic threshold of tumor cells within these chemoresistant subpopulations.
High quality Ta/PbBi tunnel junctions for 85-110 GHz SIS mixer experiments (1987)

We report on the fabrication of small area (1-6 μm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ), high critical current density (10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> A/cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) Ta/Ta oxide/ Pb <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.9</inf> Bi <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.1</inf> SIS tunnel junctions and six junction series arrays designed for use as broadband SIS quasiparticle mixers as 85-110 GHz. These junctions have small subgap leakage currents (1 to 5%), and a "sharp" current rise of width ΔV ∼30-50 μV at the sum gap voltage. An RF filter is fabricated on the substrate along with the junctions. The impedance of this filter combined with the junction capacitance is designed to provide a broadband RF match to the mixer over the entire frequency range. A sliding backshort is the only mechanical tuning element. The single junctions as well as arrays are fabricated with a window geometry on fused quartz substrates. The fused quartz substrates require the deposition of a thin amorphous Ge layer which is conducting as room temperature to avoid charging effects during the ion-beam processing steps. Preliminary measurements at 85- 100 GHz show a relatively low gain (-6.9 dB) compared to the performance expected for junctions of this quality. Model calculations suggest that the low gain arises from errors in the implementation of the RF filter design; this can be improved in future work.
RTHP-25. TTFIELDS DOSE DISTRIBUTION ALTERS TUMOR GROWTH PATTERNS: AN IMAGING-BASED ANALYSIS OF THE RANDOMIZED PHASE 3 EF-14 TRIAL (2019)

Abstract INTRODUCTION A recent post-hoc analysis of the EF-14 phase 3 trial showed a connection between TTFields dose at the tumor and Overall Survival in new diagnosed Glioblastoma (ndGBM) patients [1]. Here we expand the results of that study and show a connection between TTFields dose distribution in the brain and progression patterns in ndGBM patients. METHODS Participants of the EF-14 trial who exhibited radiological progression were included in this study (treatment: N=306/466, control: N=122/229). Enhancing tumor was segmented on T1c MRIs at baseline and progression. Regions of progression disconnected from the original lesion were defined as distal. The rates of occurrence and distances of distal progressions from primary lesions were compared between the arms. Computational head models were created and delivery of TTFields numerically simulated for n=229 patients in treatment for over 2. Dose in regions of progression was compared to dose in regions where no progression occurred. RESULTS The median distance between primary and distal lesions was larger in the treatment arm (control: 14.2±14.4 mm, TTFields 23.2±29.8 mm, p=0.03 Wilcoxon rank-sum). A higher rate of distal progression outside of a 20mm boundary zone around the primary lesion was observed in the treatment arm. (Control: 10/122, TTFields: 53/306 p&lt; 0.02 chi-squared). In proximity to the primary lesion (a 3 mm ring around the tumor), TTFields dose was lower in regions of progression than in regions where no progression occurred (0.73 mW/cm^3 vs. 0.79 mW/cm^3 p&lt; 0.0001 t-test) DISCUSSION AND CONCLUSIONS This study suggests that TTFields alters progression patterns and that progression is more likely to occur in regions exposed to low TTFields dose. The study emphasizes the rationale for adaptive TTFields treatment planning targeting regions of progression. [1] Ballo et. al., IJROBP (2019)
Impact of Senescent Cell Subtypes on Tissue Dysfunction and Repair: Importance and Research Questions (2021)

Cellular senescence, first observed and defined through cell culture studies, is a cell fate associated with essentially permanent cell cycle arrest and that can be triggered by a variety of inducers. Emerging evidence suggests senescence is a dynamic process with diverse functional characteristics. Depending on the tissue, type of inducer, and time since induction, senescent cells can promote tissue repair and re-modeling, prevent tumor development, or contribute to age-related disorders and chronic diseases, including cancers. Senescent cell characteristics appear to depend on multiple factors and be influenced by the milieu and other senescent cells locally and at a distance. We review diverse phenotypes of senescent cells originating from different cell types, senescence inducers over time since induction of senescence, and across conditions and diseases. This background is essential to inform further understanding about senescent cell subtypes and will point towards rational senescence-modulating strategies for achieving therapeutic benefit.
Tyrosine Phosphorylation of Runx1 In Megakaryocytes by Src Family Kinases (2010)

Abstract Abstract 742 Runx1 and its cofactor, CBF-beta, are the most frequent targets of chromosomal translocations in human leukemias. Point mutations in Runx-1 also occur in some cases of myelodysplastic syndrome and undifferentiated leukemia. During normal hematopoiesis, Runx1 is required for the ontogeny of all definitive hematopoietic stem cells and for the proper maturation of megakaryocytes (Mks) and lymphocytes. Despite these critical roles, the regulation of Runx1 activity via cell signaling pathways remains incompletely understood. Here, we report that Runx-1 is tyrosine phosphorylated in Mks. This occurs on multiple residues and is mediated by src-family tyrosine kinases (SFKs). Loss of Runx1 tyrosine phosphorylation correlates with phorbol ester induced differentiation of L8057 megakaryoblastic cells, suggesting a negative regulatory function. Consistent with this model, retroviral expression of a tyrosine non-phosphorylatable mutant Runx1 molecule increases primary murine fetal liver Mk maturation and Runx1 target gene expression to a greater extent than wild type Runx1. Moreover, treatment of wild type primary Mks with SFK inhibitors markedly enhances Mk maturation, as previously reported (Lannutti BJ, et al 2005 Blood;105:3875-3878). Treatment of L8057 cells with the pan-tyrosine phosphatase inhibitor Na3VO4, significantly increases Runx1 tyrosine phosphorylation levels, suggesting that tyrosine phosphorylation of Runx1 is dynamically regulated under steady-state conditions. Using a proteomic approach, we found that Runx1 physically interacts with the non-receptor tyrosine phosphatase SHP-2 (Ptpn11). We validated this interaction and showed that it occurs via direct interactions involving the Runx1 runt domain. ShRNA mediated knock down of SHP-2 in L8057 cells increases Runx1 tyrosine phosphorylation levels. Conditional knockout of SHP-2 in Mks using SHP-2fl/fl, PF4-Cre mice leads to reduced peripheral blood platelet counts and delayed platelet recovery following transient anti-GPIb antibody induced immune thrombocytopenia. Lastly, we show that treatment of TPA-induced L8057 cells with Na3VO4 markedly diminishes binding between Runx1 and the key Mk transcription factor GATA-1. Taken together, our data suggest that tyrosine phosphorylation of Runx1 via SFKs inhibits Runx1 function. Dephosphorylation, at least in part via SHP-2, relieves this inhibition and promotes Mk maturation. These effects are likely mediated through altered protein-protein interactions. Disclosures: No relevant conflicts of interest to declare.
Power line field sensing to support autonomous navigation of small unmanned aerial vehicles (2013)

Autonomous navigation around power lines in a complex urban environment is a critical challenge facing small unmanned aerial vehicles (SUAVs). As part of an ongoing development of an electric and magnetic field sensor system designed to provide SUAVs with the capability to sense and avoid power transmission and distribution lines by monitoring their electric and magnetic field signatures, we have performed field measurements and analysis of power-line signals. We discuss the nature of the power line signatures to be detected, and optimal strategies for detecting these signals amid SUAV platform noise and environmental interference. Based on an analysis of measured power line signals and vehicle noise, we have found that, under certain circumstances, power line harmonics can be detected at greater range than the fundamental. We explain this phenomenon by combining a model of power line signal nonlinearity with the quasi-static electric and magnetic signatures of multiphase power lines.
Succinobucol‐eluting stents increase neointimal thickening and peri‐strut inflammation in a porcine coronary model (2012)

In this model, stent-based delivery of 1% succinobucol using a polymer-free stent platform increased neointimal formation and inflammation following coronary stenting.
CVD Routes to MgB<sub>2</sub> Conductors (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Liquid crystalline polyethers based on conformational isomerism. 2. Thermotropic polyethers and copolyethers based on 1-(4-hydroxyphenyl)-2-(2-methyl-4-hydroxyphenyl)ethane and flexible spacers containing an odd number of methylene units (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLiquid crystalline polyethers based on conformational isomerism. 2. Thermotropic polyethers and copolyethers based on 1-(4-hydroxyphenyl)-2-(2-methyl-4-hydroxyphenyl)ethane and flexible spacers containing an odd number of methylene unitsVirgil Percec and Raymond YourdCite this: Macromolecules 1989, 22, 2, 524–537Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/ma00192a004https://doi.org/10.1021/ma00192a004research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Coexistence Performance Enhancement Techniques for DRP Based WLAN/WPAN and Cellular Radios Collocated in a Mobile Device (2006)

The incorporation of Bluetooth and Wireless LAN transceivers in a mobile devices poses design challenges associated with their coexistence with the cellular transceiver, as they often need to operate concurrently and their close proximity is inevitable. We present some recently developed techniques that transform the RF and analog circuit design complexities, typically encountered when targeting enhanced coexistence performances, into the digital domain, and demonstrate how these techniques allow the concurrent operation of two transceivers without each of them adversely impacting the performance of the other. The ideas presented have been implemented in a commercial Bluetooth single chip transceiver offered by Texas Instruments.
Effective Strategy for Conformer-Selective Detection of Short-Lived Excited State Species: Application to the IR Spectroscopy of the N1H Keto Tautomer of Guanine (2016)

The ultrafast deactivation processes in the excited state of biomolecules, such as the most stable tautomers of guanine, forbid any state-of-the-art gas phase spectroscopic studies on these species with nanosecond lasers. This drawback can be overcome by grafting a chromophore having a long-lived excited state to the molecule of interest, allowing thus a mass-selective detection by nanosecond R2PI and therefore double resonance IR/UV conformer-selective spectroscopic studies. The principle is presently demonstrated on the keto form of a modified 9-methylguanine, for which the IR/UV double resonance spectrum in the C═O stretch region, reported for the first time, provides evidence for extensive vibrational couplings within the guanine moiety. Such a successful strategy opens up a route to mass-selective IR/UV spectroscopic investigations on molecules exhibiting natural chromophores having ultrashort-lived excited states, such as DNA bases, their complexes as well as peptides containing short-lived aromatic residues.
Hole in one: Pathways to deterministic single-acceptor incorporation in Si(100)-2$\times$1 (2021)

Stochastic incorporation kinetics can be a limiting factor in the scalability of semiconductor fabrication technologies using atomic-precision techniques. While these technologies have recently been extended from donors to acceptors, the extent to which kinetics will impact single-acceptor incorporation has yet to be assessed. We develop and apply an atomistic model for the single-acceptor incorporation rates of several recently demonstrated precursor molecules: diborane (B$_2$H$_6$), boron trichloride (BCl$_3$), and aluminum trichloride in both monomer (AlCl$_3$) and dimer forms (Al$_2$Cl$_6$), to identify the acceptor precursor and dosing conditions most likely to yield deterministic incorporation. While all three precursors can achieve single-acceptor incorporation, we predict that diborane is unlikely to achieve deterministic incorporation, boron trichloride can achieve deterministic incorporation with modest heating (50 $^{\circ}$C), and aluminum trichloride can achieve deterministic incorporation at room temperature. We conclude that both boron and aluminum trichloride are promising precursors for atomic-precision single-acceptor applications, with the potential to enable the reliable production of large arrays of single-atom quantum devices.
A computational system for modelling flexible protein-protein and protein-DNA docking. (1998)

A computational system is described that predicts the structure of protein/protein and protein/DNA complexes starting from unbound coordinate sets. The approach is (i) a global search with rigid-body docking for complexes with shape complementarity and favourable electrostatics; (ii) use of distance constraints from experimental (or predicted) knowledge of critical residues; (iii) use of pair potential to screen docked complexes and (iv) refinement and further screening by protein-side chain optimisation and interfacial energy minimisation. The system has been applied to model ten protein/protein and eight protein-repressor/DNA (steps i to iii only) complexes. In general a few complexes, one of which is close to the true structure, can be generated.
<i>Haemophilus influenzae</i> Type a Infection and Its Prevention (2007)

Haemophilus influenzae was first described by Pfeiffer in 1892 ([30][1]). Forty years later Pittman identified six capsular polysaccharides (types) of H. influenzae (a, b, c, d, e, and f) whose structures were later elucidated (Table [1][2]) ([12][3], [31][4], [40][5]). Systemic infections in
The influence of pea products on the functional properties of frankfurters (2014)

The aim of this study was to compare the functional properties of two pea products – the commercial product PeaTex and lyophilized peas and to determine their effects on the quality of frankfurters. Pea products differed in the composition of their protein fractions – PeaTex had a lower albumin content. Lyophilized peas were characterized by a better water-binding capacity at ambient temperature (1.62 ml/g). The highest emulsification capacity was observed for PeaTex (57.8%) at a NaCl concentration of 40 g/kg. The yield of model meat systems composed of minced meat, pea products and salt, determined after heat treatment, was positively affected by increasing amounts of substitutes and salt content, but higher fat content had a negative effect on the yield. Frankfurters produced with the addition of lyophilized peas exhibited the highest yield (91.32%); however, they were characterized as being darker and less red in comparison with frankfurters produced with PeaTex.
Supplementary Tables 1 - 5 from miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts (2023)

&lt;p&gt;XLS file, 48K, Supplemental Figure 1: (A) Laser microdissection in an IPMN (hematoxylin and eosin; original magnification: 10x); (B) After precise marking and microdissection the neoplastic epithelium is catapulted into a sterile tube for subsequent RNA extraction. (C) The section after dissection. Supplemental Figure 2: Detailed diagram of the study design, describing experimental setup of FFPE (FTS) and cyst fluid (CFS) studies, including number of specimens used and number of miRNA candidates identified in the course of each study. Supplemental Figure 3: Mean Cts for all FTS and CFS specimens. (A) Megaplex RT-qPCR data for FTS. (B) and (C) Singleplex RT-qPCR data for FTS. (D) Megaplex RT-qPCR data for CFS. (E) and (F) Singleplex RT-qPCR data for CFS. Supplemental Figure 4: Boxplots showing raw Ct values for Megaplex (A) and singleplex (B) RT-qPCR expression analyses of FTS1 and FTS1 plus FTS2, respectively. The diagnosis associated with each sample is indicated by color, while the FTS1 and FTS2 specimens are depicted as separate panels in the singleplex boxplot (B). Supplemental Figure 5: Boxplots showing raw Ct values for Megaplex (A) and singleplex (B) RT-qPCR expression analyses of cyst fluid specimens from the CFS1 and CFS1 plus CFS2, respectively. Diagnosis is indicated by color, the CFS1 and CFS2 specimens by panel. Supplemental Figure 6: Boxplots of raw Ct values for singleplex RT-qPCR expression analysis of the CFS1 and CFS2 specimens with reassignment to test or training set indicated by separation of panels. Supplemental Figure 7: Raw Ct values of miRNAs involved in DiffPairs comprising the logistic regression model in the CFS1 and CFS2 specimens. Raw Ct for miR-21, which is not a part of the logistic regression model, are also shown. Supplemental Figure 8: PCA applied to raw Cts (A) and restricted mean-center normalized Cts. (B) CFS1 and CFS2 singleplex RT-qPCR data. Note that CFS1 and CFS2 specimens do not separate in either plot.&lt;/p&gt;
Ask a Pathologist (2017)

Question: I ordered serologic testing for Lyme disease for one of my patients and I’m not sure how to interpret the results of the Western blot. The blot shows a few dark bands, but the report indicates it is not sufficient to definitively diagnose Lyme disease. Is it possible to have a "partial positive" result?
D003: Un Nuevo Producto Obtenido De La Cera De Caña De Azucar Con Utilidad Promisoria En El Manejo De Desordenes Aterotromboticos (2004)

La aterosclerosis es un proceso patológico que constituye la base de las enfermedades oclusivas arteriales, entre las cuales se encuentran, las coronarias (EC), cerebrovasculares y periféricas, las que representan las principales causas de morbi-mortalidad en los sujetos de edad media y avanzada en los países desarrollados y en Cuba. Ha sido demostrado que la hipercolesterolemia (HC), en especial la asociada a la elevación del colesterol transportado por las lipoproteínas de baja densidad (LDL tre los-C), se encuentra en tres principales factores de riesgo coronario.
Quantifying the Impact of Prognostic Distance on Average Cost per Cycle (2019)

Prognostics and health management (PHM) is transforming reliability engineering with methods to enhance safety by accurately estimating end of useful life, thereby recommending maintenance of critical components and systems to manage cost. Previous studies emphasized degradation modeling and algorithms to improve state of health predictions. However, most of these techniques focused on improving the accuracy of predictions within a single maintenance interval, while fewer studies considered the effectiveness of alternative degradation models over multiple successive maintenance intervals. This paper develops a measure based on concepts from maintenance theory to provide a framework to objectively compare the effectiveness of existing and future battery degradation models over multiple maintenance intervals. The approach quantifies the impact of prognostic distance on average cost per cycle during the lifetime of a system. The approach is applied to state of health prediction for lithium-ion batteries, which are widely used in various mission-critical systems. The results indicate that the approach can be used to select a prognostic distance that minimizes average cost. The approach can thus evaluate models to select a suitable prognostic distance.
Bottom-Up Synthesis of Polymer Nanocomposites and Molecular Composites:  Ionic Exchange with PMMA Latex (2002)

Ionic exchange between electrostatically stabilized PMMA latex and aqueous dispersion of nanoparticles or rigid-rod polyelectrolytes of opposite sense is demonstrated to be a flexible approach to fabrication of polymeric-based nano and molecular composites, including layered silicates, indium tin oxide nanoparticles, rigid-rod polyelectrolyte, and carbon nanofibers. The exchange reaction produces a nanoscale coating on the polymer latex surface, providing efficient dispersion of the nanoparticle, interfacial control between the constituents, as well as the potential for hierarchical morphology control. The resulting nano and molecular scale dispersions are thermodynamically stable when an emulsifier that participates with the free-radical polymerization of the MMA is used. The result is direct ionic coupling between the polymer and the nanoparticle, but at a sufficiently low level to maintain solution and melt processibility. Molecular composites of sPBI and PMMA are discussed in detail, and demonstrate increases in heat distortion temperature (17 °C) and rubbery modulus (210%) with less than 1% incorporation of the rigid-rod polymer electrolyte.