gebhart/patrepeval huggingface dataset:
Exploiting pipelining to relax register-file port constraints of instruction-set extensions (2005)

Customisable embedded processors are becoming available on the market, thus making it possible for designers to speed up execution of applications by using Application-specific Functional Units (AFUs), implementing Instruction-Set Extensions (ISEs). While these processors have become available, the state of the art on automatic ISE identification is improving; many algorithms are being proposed for choosing, given the application's source code, the best ISEs under various constraints. Read and write ports between the AFUs and the processor register file are an expensive asset, fixed in the microarchitecture---some processors indeed only allow two read and one write ports---and, on the other hand, a large availability of inputs and outputs to and from the AFUs exposes high speedup. This paper proposes a solution to the limitation of actual register file ports by serialising register file access and therefore addressing multi-cycle read and write. It does so in an innovative way for two reasons: (1) it exploits and brings forward the progress in ISE identification under constraint [1, 16, 4, 19] and (2) it combines register file access serialisation with pipelining in order to obtain the best global solution. This paper proposes an algorithm for scheduling graphs---corresponding to ISEs---under input/output constraint; experiments show that by using the proposed method applications can be sped-up tangibly: speedup for low I/O constraints is 32% better on average, and 65% better at best, than that obtained by state of the art techniques.
Passive Unsupervised Localization and Tracking using a Multi-Static UWB Radar Network (2021)

The indoor localization and tracking of objects and humans with high accuracy is becoming increasingly important in a number of applications including healthcare, ambient assistant-living, surveillance, among others. Since Ultra-wideband (UWB) systems have a large operating bandwidth, they can provide centimeter (cm) level localization accuracy in Line-of-Sight (LoS) scenarios. However, current commercial UWB systems require the target to carry an active device (tag) so that it can be precisely located and this may be impractical in applications such as security and surveillance. In this work, we process experimental data obtained from a multi-static UWB radar network for the passive indoor localization of a moving target. Current fingerprinting-based passive localization techniques require a substantial radio-map survey in the offline training phase and labor-intensive fingerprint updates when there are changes in the environment. In this work, on the other hand, we propose to use the fine-grained physical layer information, known as Channel Impulse response (CIR), that is exchanged between UWB modules and capitalize on the fact that a moving person induces variations in the CIR that stand out against the background signal. Our results show that a walking target can be passively located with a median distance error as low as 0.55m in an indoor environment.
Deficiency in Lymphotoxin β Receptor Protects From Atherosclerosis in apoE-Deficient Mice (2015)

These findings suggest that LTbR plays a role in macrophage-driven inflammation in atherosclerotic lesions, probably by augmenting the Ccl5-mediated recruitment of monocytes.
SkiAR (2016)

Winter sports like skiing and snowboarding are often group activities. Groups of skiers and snowboarders traditionally use folded paper maps or board-mounted larger-scale maps near ski lifts to aid decision making: which slope to take next, where to have lunch, or what hazards to avoid when going off-piste. To enrich those static maps with personal content (e.g., pictures, prior routes taken, or hazards encountered), we developed SkiAR, a wearable augmented reality system that allows groups of skiers and snowboarders to share such content in-situ on a printed resort map while on the slope.
Study of neutron-deficient isotopes of Fl in the<sup>239</sup>Pu,<sup>240</sup>Pu +<sup>48</sup>Ca reactions (2016)

The results of the experiments aimed at the synthesis of Fl isotopes in the 239Pu + 48Ca and 240Pu + 48Ca reactions are presented. The experiment was performed using the Dubna gas-filled recoil separator at the U400 cyclotron. In the 239Pu+48Ca experiment one decay of spontaneously fissioning 284Fl was detected at 245-MeV beam energy. In the 240Pu+48Ca experiment three decay chains of 285Fl were detected at 245 MeV and four decays were assigned to 284Fl at the higher 48Ca beam energy of 250 MeV. The α-decay energy of 285Fl was measured for the first time and decay properties of its descendants 281Cn, 277Ds, 273Hs, 269Sg, and 265Rf were determined more precisely. The cross section of the 239Pu(48Ca,3n)284Fl reaction was observed to be about 20 times lower than those predicted by theoretical models and 50 times less than the value measured in the 244Pu+48Ca reaction. The cross sections of the 240Pu(48Ca,4-3n)284,285Fl at both 48Ca energies are similar and exceed that observed in the reaction with lighter isotope 239Pu by a factor of 10. The decay properties of the synthesized nuclei and their production cross sections indicate rapid decrease of stability of superheavy nuclei with departing from the neutron number N=184 predicted to be the next magic number.
Discrete Multitone Modulation for Maximizing Transmission Rate in Step-Index Plastic Optical Fibers (2009)

The use of standard 1-mm core-diameter step-index plastic optical fiber (SI-POF) has so far been mainly limited to distances of up to 100 m and bit-rates in the order of 100 Mbit/s. By use of digital signal processing, transmission performance of such optical links can be improved. Among the different technical solutions proposed, a promising one is based on the use of discrete multitone (DMT) modulation, directly applied to intensity-modulated, direct detection (IM/DD) SI-POF links. This paper presents an overview of DMT over SI-POF and demonstrates how DMT can be used to improve transmission rate in such IM/DD systems. The achievable capacity of an SI-POF channel is first analyzed theoretically and then validated by experimental results. Additionally, first experimental demonstrations of a real-time DMT over SI-POF system are presented and discussed.
Effect of an Oxides Composite Support of Ce(Sm)O&lt;sub&gt;3&lt;/sub&gt;-La(Sr)CrO&lt;sub&gt;3&lt;/sub&gt; on Pd-Ni Alloy for Decomposition Activity of CH&lt;sub&gt;4&lt;/sub&gt; (2010)

A Pd-Ni/La(Sr)CrO3-Ce(Sm)O2 composite anode showed good performance for solid oxide fuel cell reactions with dry CH4. Compositions of Pd and Ni in the Pd-Ni/La(Sr)CrO3-Ce(Sm)O2 composite anode affected the electrochemical oxidation catalysis of dry CH4. The Pd and Ni ratios from 50:50 to 75:25 were suitable for the oxidation. The Pd-Ni/La(Sr)CrO3-Ce(Sm)O2 composite anode showed the high tolerance to the carbon deposition under closed and open circuit conditions. A Pd-Ni/Ce(Sm)O2 catalyst showed very low catalytic activity for decomposition of dry CH4. A Pd-Ni/SiO2 catalyst showed very high catalytic activity for the decomposition of dry CH4 and a large amount of deposited carbon formed. The Pd-Ni particles on SiO2 were quite multifaceted from TEM-EDS observation. On the other hand, the Pd-Ni particles on Ce(Sm)O2 support had a spherical shape and doping of Ce and Sm was confirmed. This nature should inhibit the formation of particular plane that is essential for the carbon fiber formation. The detail function of Ce(Sm)O2 and La(Sr)CrO3 supports was discussed.
Enantioselective Catalytic Asymmetric Hydrogenation of Ethyl Acetoacetate in Room Temperature Ionic Liquids. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Smoothing and interpolation in a convex subset of a Hilbert space : II. The semi-norm case (1991)

accord avec les conditions gnrales d'utilisation (http://
ChemInform Abstract: Design, Synthesis and Structure—Activity Relationships of (Indo‐3‐yl) Heterocyclic Derivatives as Agonists of the CB1 Receptor. Discovery of a Clinical Candidate. (2011)

Abstract The expansion of the SAR of a novel series of indole‐3‐heterocyclic CB1 receptor agonists is reported.
Complexes of Fabs with a mimetic of the HIV-1 gp41 trimeric coiled-coil. (2014)

A series of mini-antibodies (monovalent and bivalent Fabs) targeting the conserved internal trimeric coiled-coil of the N-heptad repeat (N-HR) of HIV-1 gp41 has been previously constructed and reported. Crystal structures of two closely related monovalent Fabs, one (Fab 8066) broadly neutralizing across a wide panel of HIV-1 subtype B and C viruses, and the other (Fab 8062) non-neutralizing, representing the extremes of this series, were previously solved as complexes with 5-Helix, a gp41 pre-hairpin intermediate mimetic. Binding of these Fabs to covalently stabilized chimeric trimers of N-peptides of HIV-1 gp41 (named (CCIZN36)3 or 3-H) has now been investigated using X-ray crystallography, cryo-electron microscopy, and a variety of biophysical methods. Crystal structures of the complexes between 3-H and Fab 8066 and Fab 8062 were determined at 2.8 and 3.0 Å resolution, respectively. Although the structures of the complexes with the neutralizing Fab 8066 and its non-neutralizing counterpart Fab 8062 were generally similar, small differences between them could be correlated with the biological properties of these antibodies. The conformations of the corresponding CDRs of each antibody in the complexes with 3-H and 5-Helix are very similar. The adaptation to a different target upon complex formation is predominantly achieved by changes in the structure of the trimer of N-HR helices, as well as by adjustment of the orientation of the Fab molecule relative to the N-HR in the complex, via rigid-body movement. The structural data presented here indicate that binding of three Fabs 8062 with high affinity requires more significant changes in the structure of the N-HR trimer compared to binding of Fab 8066. A comparative analysis of the structures of Fabs complexed to different gp41 intermediate mimetics allows further evaluation of biological relevance for generation of neutralizing antibodies, as well as provides novel structural insights into immunogen design.
Evaluation of an inducible knockout system in insect cells based on co-infection and CRISPR/Cas9 (2023)

Due to comparably high product titers and low production costs, the baculovirus/insect cell expression system is considered a versatile production platform in the biopharmaceutical industry. Its excellence in producing complex multimeric protein assemblies, including virus-like particles (VLPs), which are considered promising vaccine candidates to counter emerging viral threats, made the system even more attractive. However, the co-formation of budded baculovirus during VLP production poses a severe challenge to downstream processing. In order to reduce the amount of budded baculovirus in the expression supernatant we developed an inducible knockout system based on CRISPR/Cas9 and co-infection with two baculoviral vectors: one bringing along the Cas9 nuclease and the other one having incorporated the sequence for sgRNA expression. With our set-up high titer viruses can be generated separately, as only when both viruses infect cells simultaneously a knockout can occur. When budding essential genes gp64 and vp80 were targeted for knockout, we measured a reduction in baculovirus titer by over 90%. However, as a consequence, we also determined lower overall eYFP fluorescence intensity showing reduced recombinant protein production, indicating that further improvements in engineering as well as purification are required in order to ultimately minimize costs and timeframes for vaccine production utilizing the baculovirus/insect cell expression system.
Symmetry breaking for pseudo-Boolean formulas (2008)

Many important tasks in design automation and artificial intelligence can be performed in practice via reductions to Boolean satisfiability (SAT). However, such reductions often omit application-specific structure, thus handicapping tools in their competition with creative engineers. Successful attempts to represent and utilize additional structure on Boolean variables include recent work on 0-1 integer linear programming (ILP) and symmetries in SAT. Those extensions gracefully accommodate well-known advances in SAT solving, however, no previous work has attempted to combine both extensions. Our work shows (i) how one can detect and use symmetries in instances of 0-1 ILP, and (ii) what benefits this may bring.
Simple and effective defense against evil twin access points (2008)

Wireless networking is widespread in public places such as cafes. Unsuspecting users may become victims of attacks based on "evil twin" access points. These rogue access points are operated by criminals in an attempt to launch man-in-the-middle attacks. We present a simple protection mechanism against binding to an evil twin. The mechanism leverages short authentication string protocols for the exchange of cryptographic keys. The short string verification is performed by encoding the short strings as a sequence of colors, rendered sequentially by the user's device and by the designated access point of the cafe. The access point must have a light capable of showing two colors and must be mounted prominently in a position where users can have confidence in its authenticity. We conducted a usability study with patrons in several cafes and participants found our mechanism very usable.
Efficient reflection grisms for pulse compression and dispersion compensation of femtosecond pulses (2006)

Efficient reflection grisms for pulse-compression and material-dispersion compensation have been designed and demonstrated in a 40 fs, 300 microJ, 5 kHz downchirped pulse amplification system for the first time to our knowledge. A grism design for 800 nm femtosecond laser pulse dispersion compensation applications is realized by using standard, commercial diffraction gratings.
Transfection of IL-10 expression vectors into endothelial cultures attenuates α4β7-dependent lymphocyte adhesion mediated by MAdCAM-1 (2003)

Our results suggest that gene therapy of the gut microvasculature with IL-10 vectors may be useful in the clinical treatment of IBD.
Pore Size Analysis of MCM-41 Type Adsorbents by Means of Nitrogen and Argon Adsorption (1998)

Methods of nonlocal density functional theory (NLDFT), proposed recently for predictions of adsorption equilibrium and calculations of pore size distributions in micro- and mesoporous materials, were tested on reference MCM-41 materials. Five newly synthesized MCM-41 adsorbents with presumably uniform pore channels varying from 32 to 45 Å were characterized by X-ray diffraction (XRD), nitrogen adsorption at 77 K, and argon adsorption at 77 and 87 K. New sets of intermolecular interaction parameters of the NLDFT model for N2 and Ar adsorption on MCM-41 were determined. The parameters were specified to reproduce the bulk liquid-gas equilibrium densities and pressures, liquid-gas interfacial tensions, and standard adsorption isotherms on nonporous surfaces in the multilayer adsorption region. The pore size distributions calculated from the desorption branches of the experimental isotherms measured at three different temperatures were consistent with each other. Comparison of the NLDFT-calculated pore sizes with XRD data showed that the thickness of pore walls in the MCM-41 samples under consideration varied from ca. 6 to 12 Å. We found no correlation between the pore size and the pore wall thickness. The results obtained support the NLDFT model as a suitable tool for characterizing nanoporous materials and predicting adsorption equilibrium. The MCM-41 samples studied can be used as references for adsorption measurements. Copyright 1998 Academic Press.
Combined Growth Hormone (GH) and Insulin-Like Growth Factor-I (IGF-I) Treatment is More Effective than GH or IGF-I Alone at Enhancing Recovery from Neonatal Malnutrition in Rats (1995)

The effect of hormonal therapy on enhancing recovery from neonatal malnutrition was assessed in rats. Malnutrition was induced by maternal food restriction (60% control intake) during lactation. On d 16 postpartum, restricted pups were refed by cross-fostering to control dams and were subcutaneously administered growth hormone (GH), insulin-like growth factor-I (IGF-I), GH + IGF-I or saline. At d 21, pups were weaned and continued hormonal treatments until d 39 postpartum. By d 39, body weight of GH (96% control) and GH + IGF-I- (98%) treated animals were normal, whereas IGF-I (88%) and saline- (85%) treated animals were still stunted. Hormone effectiveness was age dependent, with growth rates of GH + IGF-I-, IGF-I- and GH-treated pups being greatest between d 16 and 30, d 16 and 21 and after d 30, respectively. Protein accretion by d 39 was higher (P < 0.01) in GH and GH + IGF-I groups than saline- or IGF-I-treated groups. On d 39, serum IGF-I concentrations were as follows: GH + IGF-I > IGF-I > GH = saline (placebo), indicating that an elevated serum IGF-I was not required for GH-stimulated growth. Of the three hormonal treatments, GH + IGF-I therapy was most efficacious at promoting rapid and complete body weight recovery and supporting lean body mass accretion.
Mutation of glucose-6-phosphate dehydrogenase deficiency in Chinese Han children in eastern Fujian (2018)

We aim to investigate the mutation types of glucose-6-phosphate dehydrogenase (G6PD) deficiency in Chinese Han children in eastern Fujian Province.A total of 904 Chinese Han neonates (male: 733 with positive G6PD deficiency and 28 with weakly positive deficiency; female: 73 with positive G6PD deficiency and 70 with weakly positive deficiency) received G6PD screening in our center from January 2014 to December 2016 were included in this study. Additionally, 904 age-matched normal Chinese Han individuals (male: 761; female: 143) were selected as control. Neonatal G6PD deficiency screening was performed through blood sample collection from the heels, using the commercial kits. Multicolor melting curve analysis (MMCA) method was used to determine the G6PD mutation type in the 904 cases. If it failed to detect mutations in the cases with abnormal enzyme activity, the polymerase chain reaction (PCR) and gene sequencing were used to determine the mutation sites. PCR and gene sequencing were used to determine the mutation sites in the 904 individuals with normal enzyme activity. Three most common mutation types in Chinese population were compared between Fujian and other provinces.Among the 904 neonates with abnormal G6PD enzyme activity, 17 mutation types were detected including 15 single point mutations and 7 complex mutations. Three most common mutation types were c.1376G > T, c.1388G > A, and c.95A > G accounted for 72.6% of the total mutations in eastern Fujian.The proportion of mutational types in G6PD and the degree of enzyme activity change in various mutational types were found in the neonates of Fujian Province. Our study may enrich the molecular diagnosis of G6PD deficiency meaning Fujian Province.
Spreading Segregation of Blended Fertilizers: Influence of the Particles Properties (2008)

The blending of solid granular fertilizers produces an almost infinite range of compounds with some raw materials. These can be specifically matched to a farmer's needs at a reasonable cost. The main problem is that the blended fertilizers are exposed to the risk of segregation. With granular materials, the differences in physical properties can lead to the segregation of the particles. This study aims at analyzing and quantifying the particles influence on segregation during spreading of blended fertilizers. The experiment consisted of mixing two raw materials that differed by one characteristic: the size, the density, or the shape. The physical properties of each raw material were carefully measured. Twenty-six blends were spread on the field with a centrifugal spreader and samples were collected in order to measure segregation. The proportion of each component was calculated with the chemical content of the raw materials and blended samples. Two coefficients of segregation were determined. Great segregation in some cases was observed. The original proportion of 50% for each component can become 30/70 on the field. The analysis of the influence of each parameter shows that major effects occur with a difference of size and density. The influence of shape is minimal. A relationship was proposed between the differences of physical properties of the blend components and the spreading segregation.
Error distribution in maximum likelihood estimation of radio propagation model parameters (2012)

A growing demand for bandwidth in wireless data networks has motivated policy makers to consider opening underused frequencies, e.g. in the TV broadcasting bands, to opportunistic secondary access. To support secondary network operations in these TV whitespaces (TVWS), centralized databases are envisioned that employ radio propagation models to derive the spectrum usage of the primary system. Precise estimation of the actual spectrum usage is highly important in this scenario, because maladjusted models can cause primary outage or hamper secondary capacity. The requirements for accurate propagation estimation have hence further increased. Using the example of a single TV transmitter, we study in this poster the prospects of maximum likelihood estimation for generic power law propagation models. Transmitter characteristics are considered known, but environment-specific parameters of the model are derived through fitting measurement results, obtained, e.g., through drive tests. We derive for the case of uncorrelated shadow fading the error distributions and their parameters for two parameters, namely pathloss coefficient and shadow variance. Our results are applicable to other large-scale scenarios where precise signal strength estimation is required. They can help to minimize the number of required measurements and to determine necessary protection policies.
Amorphization Tendency of Ti&lt;SUB&gt;34&lt;/SUB&gt;Zr&lt;SUB&gt;11&lt;/SUB&gt;Cu&lt;SUB&gt;47&lt;/SUB&gt;Ni&lt;SUB&gt;8&lt;/SUB&gt; and Ti&lt;SUB&gt;37&lt;/SUB&gt;Zr&lt;SUB&gt;17&lt;/SUB&gt;Cu&lt;SUB&gt;42&lt;/SUB&gt;Ni&lt;SUB&gt;4&lt;/SUB&gt; during Mechanical Alloying (1998)

Pure elemental powders of Ti, Zr, Cu and Ti corresponding to the compositions of Ti34Zr11Cu47Ni8 and Ti37Zr17Cu42Ni4 (at%) were subjected to mechanical alloying on a low energy milling machine in the present work. The premixed powders of the above two compositions underwent the following transformations during mechanical alloying up to 100 h: μm-sized (Ti, Zr, Cu, Ni)→nm-sized (Ti, Zr, Cu, Ni)→amorphous+a small amount of nm-sized crystallites. The 100-h milled Ti34Zr11Cu47Ni8 sample was found to exhibit an excellent thermal stability against crystallization with the crystallization temperature of about 200 K higher than that of the as-quenched amorphous counterpart. Contrary to the previous rapid quenching result, amorphous phase is easier to occur in Ti37Zr17Cu42Ni4 than in Ti34Zr11Cu47Ni8 by MA, indicating that the glass forming ability by rapid quenching is different from that by MA.
5,6-Dihydro-5'-azacytidine (DHAC) affects estrogen sensitivity in estrogen-refractory human breast carcinoma cell lines. (1999)

These data suggest that DHAC can restore the estrogen sensitivity in ER-breast cancer. Thus, DHAC and other novel CMT inhibitors may have a clinical application in treating estrogen-refractory breast cancer patients by restoring the estrogen sensitivity and allowing these patients to respond again to conventional therapy with estrogen antagonists.
Colletotrichum metabolite higginsianin B suppresses plant jasmonate signalling by blocking proteasome-mediated degradation of JAZ proteins (2019)

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