gebhart/patrepeval huggingface dataset:
Keto boronate reduction: 1,7-asymmetric induction (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKeto boronate reduction: 1,7-asymmetric inductionGary A. Molander and Kevin L. BobbittCite this: J. Am. Chem. Soc. 1993, 115, 16, 7517–7518Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/ja00069a067https://doi.org/10.1021/ja00069a067research-articleACS PublicationsRequest reuse permissionsArticle Views400Altmetric-Citations35LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Bi-directional association between type 2 diabetes and periodontitis in the nationally representative sample comprising Taiwanese adults from 2000 to 2015 (2022)

Abstract Objective The two-way relationship between periodontitis and diabetes was advocated far past. However, the population-based bidirectional observation is still limited. Using the National Health Insurance Research Database of Taiwan, we estimate associations between pre-existing clinical periodontitis and incident type 2 diabetes mellitus (T2DM), and between pre-existing diabetes and incident periodontitis, respectively. Methods A total of 11,011 periodontitis patients who underwent periodontal therapy (Pt group) were recruited from 2000 to 2015. After matching by age, sex, and index date, 11,011 periodontitis patients who did not receive treatment (Pwt group) and 11,011 non-periodontitis controls were registered. The outcome of T2DM was traced. Conversely, 157,798 patients with T2DM and 157,798 non-diabetic controls were enrolled, whereas the development of periodontitis was traced. Cox proportional hazards model was performed. Results The patients with periodontitis tended to have a statistically high risk of having diabetes. The adjusted hazard ratio (aHR) was 1.94 [95% CI 1.49–2.63, p &lt; 0.01] and 1.72 [95% CI 1.24–2.52, p &lt; 0.01] for Pt and Pwt, respectively. Using Pwt group as a reference, patients in Pt group had a high risk of having diabetes [aHR, 1.17 (95% CI 1.04–1.26, p &lt; 0.001)]. Conversely, patients with T2DM tended to have a high risk of periodontitis [aHR, 1.99 (95% CI 1.44–2.48, p &lt; 0.01)]. However, a high risk was noticed for the outcome subgroup of Pt only [aHR, 2.08 (95% CI, 1.50–2.66), p &lt; 0.001)]. Conclusions The relationship between periodontitis and diabetes is bi-directional.
Mass spectrometry detection of monkeypox virus: Comprehensive coverage for ranking the most responsive peptide markers (2022)

The recent and sudden outbreak of monkeypox in numerous non-endemic countries requires expanding its surveillance immediately and understanding its origin and spread. As learned from the COVID-19 pandemic, appropriate detection techniques are crucial to achieving such a goal. Mass spectrometry has the advantages of a rapid response, low analytical interferences, better precision, and easier multiplexing to detect various pathogens and their variants. In this proteomic dataset, we report experimental data on the proteome of the monkeypox virus (MPXV) recorded by state-of-the-art shotgun proteomics, including data-dependent and data-independent acquisition for comprehensive coverage. We highlighted 152 viral proteins, corresponding to an overall proteome coverage of 79.5 %. Among the 1371 viral peptides detected, 35 peptides with the most intense signals in mass spectrometry were selected, representing a subset of 13 viral proteins. Their relevance as potential candidate markers for virus detection by targeted mass spectrometry is discussed. This report should assist the rapid development of mass spectrometry-based tests to detect a pathogen of increasing concern.
The Effects of Two Spacers on White Organic Light-Emitting Diodes (2008)

The authors have demonstrated highly efficient white organic light-emitting diodes (WOLEDs) by using two emissive materials as a dopant, 1,4-Bis[2-(4'-diphenylaminobiphenyl-4-yl)vinyl]benzene (DABPV-ph) and iridium(III) bis(5-acetyl-2-phenylpyridinato-N,C2') acetylacetonate ((acppy)2Ir (acac)). In these WOLEDs, 2-methyl-9,10-di(2-naphthyl)anthracene (MADN), and 4,4'-N,N'-dicarbazole-biphenyl (CBP) were used as a spacer among the three emissive layers. The maximum luminous efficiency of the three devices with no spacer, MADN and CBP as a spacer were 11.50, 8.32, and 25.70 cd/A at 0.08, 12.7, and 0.01 mA/cm2 and the Commission Internationale De L'Eclairage (CIE(x, y)) coordinates were (x = 0.21, y = 0.34), (x = 0.21, y = 0.34), and (x = 0.33, y = 0.33) at 11 V, respectively.
Low Doses of Intracoronary Enalaprilat Suppress Reperfusion‐Associated Ventricular Arrhythmias after Primary Percutaneous Coronary Interventions for Acute Myocardial Infarction (2007)

Compared with PL, i.c. EN significantly lowered the incidence of reperfusion-associated VA. This previously unrecognized antiarrhythmic effect might be an important therapeutic benefit conferred by ACE inhibitors, beyond limitation of infarct size.
Films de Langmuir d'une nouvelle molécule cage amphiphile en présence de cations complexants : Intérêt pour l'application à l'extraction d'ions par un procédé membranaire (1997)

Dans ce memoire, nous presentons les resultats concernant la caracterisation d'un film interfacial d'une nouvelle molecule cage amphiphile : le tetra-(N-2-tetradecyl-carboxamidoethyl)-tetraazacyclotetradecane ou TC14. Cette molecule est derivee du cyclam, qui possede des proprietes de complexation de certains cations metalliques. Le comportement interfacial du TC14 a ete etudie par la technique de Langmuir. Nous avons determine les isothermes? -A des molecules de TC14 a l'interface eau/air en fonction de la composition de la sous-phase et de la temperature. Les resultats obtenus revelent en particulier des modifications importantes des isothermes dans la region des hautes pressions de surface, attribuees a la complexation preferentielle des ions a l'interface (complexation Cu++>Na+>Cs+). La structure du film de TC14 a ete egalement caracterisee par microscopie a angle de Brewster et par des analyses de diffusion de rayons X en incidence rasante. Des depots des films de TC14 ont ete realises par la technique de Langmuir-Blodgett. La preuve de la presence de complexes a l'interface a ete fournie par des analyses spectroscopiques realisees sur des films moleculaires transferes sur des plaques de fluorine. Des experiences de voltametrie cyclique sur des electrodes d'or ont egalement ete realisees. En raison des applications potentielles de notre molecule a l'extraction d'ions par un procede membranaire, une partie de notre travail a consiste a developper un systeme experimental permettant la compression des films moleculaires deposes a l'interface entre deux liquides non miscibles. Les experiences realisees nous ont montre que la presence de cations complexants modifiait la structure du film de TC14 de facon similaire aux interfaces liquide/air et liquide/liquide. La sensibilite de l'experience permet de mettre en evidence la complexation preferentielle du cuivre meme en presence d'une solution de forte salinite dans les deux cas. Les travaux realises au cours de cette these nous indiquent que la technique de Langmuir est tout a fait adaptee a la recherche en amont des procedes de transfert de phase entre deux liquides.
A 4.3 GB/s Mobile Memory Interface With Power-Efficient Bandwidth Scaling (2010)

This paper presents a 4.3 GB/s mobile memory interface that utilizes low power states with rapid transition times to support power efficient signaling over a wide range of effective bandwidths. The fastest power state transition is implemented by a global synchronous clock pause that gates dynamic power consumption without any loss of system state. Extensive use of CMOS circuit topologies, with low static power consumption, provides maximum power savings when the clocks are paused. The memory controller forwards a half bit-rate clock to the memory for synchronous communication, which is similarly paused in the low power state. Thus, dynamic interface power on the memory itself naturally responds to the clock pausing, without any explicit communication from the controller or special low-power state on the memory. Low-swing differential signaling based on a push-pull voltage mode driver results in good signal integrity and power efficiency at peak activity. Test-chips fabricated in a 40 nm low-power CMOS technology achieve 3.3 mW/Gb/s power efficiency at 4.3 GB/s data bandwidth, and support better than 5 mW/Gb/s operation over a range from 0.03 to 4.3 GB/s.
Specification of effective mentoring behaviors for career success outcomes: what do good mentors do? (2014)

Although much research has been done in the past few decades to link mentors' enactment of mentoring functions (e.g., career support, psychosocial support) to career success outcomes for mentees, there has been virtually little systematic examination of the most appropriate mentoring behaviors underlying these functions. This lack of understanding of what good mentoring looks like at a specific behavioral level has been a limitation to both our understanding of the mentoring process and our ability to choose and/or train mentors. Here, we conduct a thorough literature review of the mentoring research, describe the extent to which behaviors have been specified in the scholarly literature, and extract key themes from the mentoring literature. A total of 530 unique behaviors were identified, many of which could be clustered these into one of the two higher-order mentoring functions, “career-related” and “psychosocial support.” Key themes and example behaviors are provided.
Early Neurologic Outcome after Bovine Pericardium versus Venous Patch Angioplasty in 599 Patients Undergoing Carotid Endarterectomy (2010)

Bovine pericardium was compared to great saphenous vein patch angioplasty regarding the neurologic events after carotid endarterectomy (CEA) with or without concomitant cardiac surgery (CS). From January 1996 to December 2007, 599 patients undergoing CEA (259 with concomitant CS) were enrolled; 456 patients were treated with the great saphenous vein (GSV group) and 143 were treated with bovine pericardium (BP group). Neurologic outcome and Rankin score (RS) were recorded after 24 hours and 30 days. We found comparable rates of neurologic complications (transient ischemic attack, stroke) between the two groups. Thirty-day mortality was 4% (17 of 456 patients) in the GSV group and 0% in the BP group (p = .12). None of the patients died as a consequence of a fatal stroke. Preoperative RS was a prognostic factor for postoperative neurologic deterioration (p = .001). Early neurologic outcome was comparable for the two types of patch material. Preoperative RS predicted postoperative neurologic deterioration.
Thermodynamic stability of wild-type and mutant p53 core domain (1997)

Some 50% of human cancers are associated with mutations in the core domain of the tumor suppressor p53. Many mutations are thought just to destabilize the protein. To assess this and the possibility of rescue, we have set up a system to analyze the stability of the core domain and its mutants. The use of differential scanning calorimetry or spectroscopy to measure its melting temperature leads to irreversible denaturation and aggregation and so is useful as only a qualitative guide to stability. There are excellent two-state denaturation curves on the addition of urea that may be analyzed quantitatively. One Zn2+ ion remains tightly bound in the holo-form of p53 throughout the denaturation curve. The stability of wild type is 6.0 kcal (1 kcal = 4.18 kJ)/mol at 25 degrees C and 9.8 kcal/mol at 10 degrees C. The oncogenic mutants R175H, C242S, R248Q, R249S, and R273H are destabilized by 3.0, 2.9, 1.9, 1.9, and 0.4 kcal/mol, respectively. Under certain denaturing conditions, the wild-type domain forms an aggregate that is relatively highly fluorescent at 340 nm on excitation at 280 nm. The destabilized mutants give this fluorescence under milder denaturation conditions.
Enabling a Programming Environment for an Experimental Ion Trap Quantum Testbed (2021)

Ion trap quantum hardware promises to provide a computational advantage over classical computing for specific problem spaces while also providing an alternative hardware implementation path to cryogenic quantum systems as typified by IBM's quantum hardware. However, programming ion trap systems currently requires both strategies to mitigate high levels of noise and also tools to ease the challenge of programming these systems with pulse- or gate-level operations. This work focuses on improving the state-of-the-art for quantum programming of ion trap testbeds through the use of a quantum language specification, QCOR, and by demonstrating multi-level optimizations at the language, intermediate representation, and hardware backend levels. We implement a new QCOR/XACC backend to target a general ion trap testbed and then demonstrate the usage of multi-level optimizations to improve circuit fidelity and to reduce gate count. These techniques include the usage of a backend-specific numerical optimizer and physical gate optimizations to minimize the number of native instructions sent to the hardware. We evaluate our compiler backend using several QCOR benchmark programs, finding that on present testbed hardware, our compiler backend maintains the number of two-qubit native operations but decreases the number of single-qubit native operations by 1.54 times compared to the previous compiler regime. For projected testbed hardware upgrades, our compiler sees a reduction in two-qubit native operations by 2.40 times and one-qubit native operations by 6.13 times.
Nonlinear Tactile Estimation Model Based on Perceptibility of Mechanoreceptors Improves Quantitative Tactile Sensing (2022)

Tactile sensing has attracted significant attention as a tactile quantitative evaluation method because the tactile sensation is an important factor while evaluating consumer products. Although the human tactile perception mechanism has nonlinearity, previous studies have often developed linear regression models. In contrast, this study proposes a nonlinear tactile estimation model that can estimate sensory evaluation scores from physical measurements. We extracted features from the vibration data obtained by a tactile sensor based on the perceptibility of mechanoreceptors. In parallel, a sensory evaluation test was conducted using 10 evaluation words. Then, the relationship between the extracted features and the tactile evaluation results was modeled using linear/nonlinear regressions. The best model was concluded by comparing the mean squared error between the model predictions and the actual values. The results imply that there are multiple evaluation words suitable for adopting nonlinear regression models, and the average error was 43.8% smaller than that of building only linear regression models.
Heart rate as a determinant of L-type Ca2+ channel activity: Mechanisms and implication in force-frequency relation (2000)

Early studies in enzymatically isolated animal cardiomyocytes indicated that voltage-gated “L-type” Ca2+ currents (ICaL) can be upregulated following an increase of the frequency of activation. Recently, we evidenced a similar regulation of ICaL in human cardiomyocytes from both left and right ventricles and atria over a physiopathological range of stimulations (between 0.5 and 5 Hz). This regulation, enhanced by the β-adrenergic stimulation, may be involved in the frequency-dependent potentiation of cardiac contractile force in the human healthy myocardium. We show here that the frequency-dependent regulation of ICaL is con-troled by the level of phosphorylation, as well as dephosphorylation, of the Ca2+ channels. It was enhanced following activation of the protein kinase A activated by intracellular cyclic AMP (cAMP). Therefore, we anticipate that all agents stimulating cAMP production will favor this process, which was demonstrated here by activating 5HT-4 receptors using serotonin. Alternatively, it was also enhanced by the phosphatase inhibitor okadaic acid which prevents Ca2+ channels dephosphorylation. Alteration or abnormal modulation by β-adrenergic receptor stimulation of the frequency-dependent facilitation of ICaL may partly explain the altered force-frequency relation described in heart failure.
Electronic Structure Trends in N‐Heterocyclic Carbenes (NHCs) with Varying Number of Nitrogen Atoms and NHCTransition‐Metal Bond Properties (2013)

Carbenes derived from five-membered heterocycles with different numbers of nitrogen atoms ranging from two to four lead formally either to normal N-heterocyclic or mesoionic carbenes with, in some cases, the same skeletal structure. The electronic structures of fourteen of these compounds were examined by means of DFT calculations at the B3LYP/aug-cc-pVTZ level. The examined parameters include the energies of the σ-lone pair at Ccarbene and the π-HOMO of the protonated form, which are correlated to the first and second proton affinities. The singlet-triplet energy gap was used as a measure of the stability of the N-heterocyclic carbene (NHC) towards dimerisation. Natural population analysis provided insight into the variation of the pπ population and the natural charge at Ccarbene with NHC structure. Additionally, the transition metalNHC bond in L-AuCl and L-TiCl4 and the nature of the orbital interactions between the NHC and the transition-metal fragment were analysed in detail by the extended transition state-natural orbitals for chemical valence (ETS-NOCV) approach at the BP86/TZ2P level. Similarities and differences between the NHCgold and the NHCtitanium bond are discussed, and trends in key bonding properties can be traced back to the variation of the electronic parameters of the NHC.
Decreased IL-12 Production Underlies the Decreased Ability of Male Lymph Node Cells to Induce Experimental Autoimmune Encephalomyelitis (1999)

Myelin basic protein (MBP)-specific T lymphocytes from male SJL mice were shown to be less encephalitogenic than MBP-specific T lymphocytes from females. Mechanisms underlying this gender difference in the induction phase of EAE were examined. Following immunization with MBP, draining lymph nodes contained fewer cells, and Ag-specific proliferative responses were decreased in males as compared with females. These gender differences in the proliferative response were not unique to MBP-specific responses since they were also observed after immunization with hen eggwhite lysozyme. Short-term MBP-specific T cell lines derived from females and males mapped with identical specificity, indicating no defect in the ability of male APCs to process Ag. Interestingly, IL-12 and IFN-gamma production was decreased following Ag-specific stimulation of draining lymph node cells (LNC) from males as compared with females, but IL-10 and IL-4 were no different. While male-derived LNCs were less encephalitogenic than female derived LNCs, cotransfer and coculture of male LNCs with female LNCs demonstrated that male LNCs were not immunosuppressive. Administration of IL-12 to LNCs from male mice enhanced encephalitogenicity. These data indicate that deficient endogenous IL-12 production within draining LNCs of male SJL mice is central to gender differences in the induction phase of experimental autoimmune encephalomyelitis.
Xray Exposure Time in Dedicated Academic Simulation Programs Is Realistic of Patient Procedures (2022)

To ascertain whether simulated endovascular procedures are comparable to real life operating room (OR) procedures, particularly with regard to irradiation time. This was a retrospective study comparing simulation with clinical data. Fluoroscopy time and overall operation time were compared between simulated abdominal aortic endovascular repair (EVAR) and iliac procedures that were performed, respectively, from 2016 to 2019 and from 2015 to 2019, and clinical EVAR and iliac procedures performed in the OR between January 2018 and November 2021. Within the defined periods, 171 simulated procedures (91 EVAR, 80 iliac) and 199 clinical procedures (111 EVAR, 88 iliac) were performed. For both EVAR and iliac procedures, median total procedure time was much longer during real surgery (p < .001). However, median total fluoroscopy time remained the same, whether the procedure was real surgery or performed on the simulator, for iliac procedures (8.47 minutes in the OR, 8.35 minutes on the simulator, p = .61) and for EVAR procedures (14.80 minutes in the OR, 15.00 minutes on the simulator p = .474). Simulated endovascular procedures are comparable with real life OR procedures, particularly with regard to irradiation time when integrated in a dedicated curriculum.
A compact differential absorption lidar for tropospheric ozone measurement (2003)

Summary form only given. Remote measurements of ozone concentrations are commonly performed using either the differential absorption lidar (DIAL) or Raman technique. The DIAL technique for tropospheric ozone requires laser wavelengths in the 285-295 nm region. We propose a very compact DIAL system based on an all solid state laser system consisting of a Nd:YAG pumped, tunable Ce:LiCrAlF/sub 6/ laser as the transmitter, operating in the solar blind region for day/night monitoring of the tropospheric ozone.
Mastery in Clinical Occupational Therapy (1990)

This study sought to describe the characteristics of mastery in occupational therapy practice. A Delphi survey (i.e., an inquiry technique used to predict and define constructs [Linstone & Turoff, 1975]) of 33 occupational therapy experts was conducted to obtain their conceptions of the characteristics of occupational therapy mastery. Three master clinicians, identified by the expert respondents, were then interviewed to validate and illustrate the concepts of mastery identified in the Delphi survey. The results suggest that mastery is a combination of selected personal traits, creative and flexible judgment, the use of occupation as the foundation for practice decisions, and a strong commitment to occupational therapy practice. Further, mastery is expressed through a personal style that is unique to each clinical master.