gebhart/patrepeval huggingface dataset:
A Barcode-Free Combinatorial Screening Platform for Matrix Metalloproteinase Screening (2014)

Application of droplet microfluidics to combinatorial screening applications remains elusive because of the need for composition-identifying unique barcodes. Here we propose a barcode-free continuous flow droplet microfluidic platform to suit the requirements of combinatorial screening applications. We demonstrate robust and repeatable functioning of this platform with matrix metalloproteinase activity screening as a sample application.
Effects of spatial attention on disparity thresholds in detecting dual targets in the central and peripheral visual field (2010)

To examine influences of selective spatial attention on stereo performance we measured disparity thresholds to detect dual targets presented simultaneously in the central and in the peripheral visual field, respectively. A random dot stereogram subtending 29° by 29° was presented for 0.2 s while the observer fixated at the central fixation point. A square-shaped target was defined by crossed disparity. We used the following four experimental conditions. The first two provided the baseline performance. In the center-only condition the target was of 1° size and presented at 2° eccentricity. The direction of the target relative to the fixation point was either one of eight directions in 45° steps. The observer's task was to indicate the direction of the target in 8AFC manner. In the surround-only condition the stimulus pattern was the same except that the size and eccentricity of the target were five times larger than those in the center-only condition. In the center-priority condition the central and peripheral targets were presented simultaneously while the observer paid more attention to the center target. In the surround-priority condition more attention was paid to the surround target. For comparison thresholds to detect luminance-defined targets were determined using the same experimental paradigm. The results showed that threshold elevation occurred almost exclusively for the less attended targets, and that the magnitudes of threshold elevation were in up to 0.5 log-unit range for most observers. They were much larger than those for luminance detection. It appears that precise stereoscopic depth judgments need spatial attention.
Otcomes of Anterior Cruciate Ligament Injuries to Running Backs and Wide Receivers in the National Football League (2006)

Nearly four fifths of National Football League running backs and wide receivers who sustain an anterior cruciate ligament injury return to play in a game. On return to competition, player performance of injured players is reduced by one third.
Analysis of expressed sequence tags from a significant livestock pest, the stable fly (<i>Stomoxys calcitrans</i>), identifies transcripts with a putative role in chemosensation and sex determination (2010)

The stable fly, Stomoxys calcitrans L. (Diptera: Muscidae), is one of the most significant pests of livestock in the United States. The identification of targets for the development of novel control for this pest species, focusing on those molecules that play a role in successful feeding and reproduction, is critical to mitigating its impact on confined and rangeland livestock. A database was developed representing genes expressed at the immature and adult life stages of the stable fly, comprising data obtained from pyrosequencing both immature and adult stages and from small-scale sequencing of an antennal/maxillary palp-expressed sequence tag library. The full-length sequence and expression of 21 transcripts that may have a role in chemosensation is presented, including 13 odorant-binding proteins, 6 chemosensory proteins, and 2 odorant receptors. Transcripts with potential roles in sex determination and reproductive behaviors are identified, including evidence for the sex-specific expression of stable fly doublesex- and transformer-like transcripts. The current database will be a valuable tool for target identification and for comparative studies with other Diptera.
Degradation mechanisms in 3-5 compound semiconductor devices and structures (1990)

This book contains the proceedings of a symposium on degradation mechanisms in III-V compound semiconductor devices and structures, part of the 1990 Materials Research Society Spring Meetings. Topics covered include: reliability and degradation of electronic devices, recombination enhanced motion and related effects, defects in epitaxial layers, degradation of photonic devices, stress effects in device degradation, and reliability in metal III-V systems.
Medical video streaming utilizing MPEG-DASH (2013)

This paper presents an analysis of medical video streaming based on the Dynamic Adaptive Streaming over HTTP (DASH) standard from the Moving Picture Experts Group (MPEG).We propose two adaptation approaches at the client and evaluate parameters of the Quality of Experience (QoE), i.e., the quality perceived by the users, by investigating the number and duration of re-buffering events, the added time in the playout, and the Peak Signal-to-Noise Ratio (PSNR) of the medical video frames. The results show that the selection of MPEG-DASH related parameters and the adaptation approach at the client result in improved quality of the medical video streaming. In the end, we discuss how the elaborated approaches and results could be utilized to facilitate and enhance telemedicine applications.
Discerning the kinetics of autoimmune manifestations in a model of Sjögren's syndrome (2014)

Ectopic follicles are non-encapsulated organized lymphoid structures that form at sites of inflammation and presumably contribute to the activation and differentiation of cells with autoreactive potential within target tissues. As such, directed targeting of ectopic follicles in settings of autoimmunity may provide a means to specifically inhibit the activation of autoreactive cells without impairing protective immune responses ongoing in peripheral lymphoid tissues. NOD·H2h4 mice are a non-diabetic strain of NOD mice which develop a Sjögren's syndrome-like disease which includes the formation of ectopic follicles in the salivary gland and characteristic Sjögren's autoantibodies. The goal of these studies was to better characterize the formation of ectopic follicles in this model and to explore their contribution to autoimmunity. Our studies show that by 8 weeks of age, young NOD·H2h4 mice spontaneously develop an abundance of splenic germinal centers, prior to the emergence of lymphocyte infiltration in the salivary gland tissue. Ectopic follicle formation in the salivary gland begins to appear in these mice between 12 and 16 weeks of age. Interestingly, anti-Ro and anti-La autoantibodies precede the development of ectopic follicles in young NOD·H2h4 mice. In contrast, production of anti-dsDNA antibodies is delayed and largely coincides with the formation of ectopic follicles in these mice. These data suggest that tertiary lymphoid structures may arise from the trafficking of activated T and B cells to sites of inflammation in non-lymphoid tissues. Furthermore, local presentation of autoantigens may then promote the expansion of autoreactive cells with specificities distinct from those generated in the splenic micro-environment.
Supplementary Figure 1 from Effect of Montanide and Poly-ICLC Adjuvant on Human Self/Tumor Antigen-Specific CD4&lt;sup&gt;+&lt;/sup&gt; T Cells in Phase I Overlapping Long Peptide Vaccine Trial (2023)

&lt;p&gt;PDF file - 13027K, Comparison of apparent avidities of NY-ESO-1-specific CD4+ T cells before and after vaccination. Apparent avidity (EC50) for recognition of the NY-ESO-1 assay OLP was determined for NY-ESO-1-specific CD4+ T cell lines before and after the vaccination. (A) Cohort 1 (OLP alone); (B) Cohort 2 (OLP in Montanide); and (C) Cohort 3 (OLP and poly-ICLC in Montanide).&lt;/p&gt;
Genetic propensities for verbal and spatial ability have opposite effects on body mass index and risk of schizophrenia (2021)

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Download
A New Method to Visualize Deep Neural Networks (2016)

We present a method for visualising the response of a deep neural network to a specific input. For image data for instance our method will highlight areas that provide evidence in favor of, and against choosing a certain class. The method overcomes several shortcomings of previous methods and provides great additional insight into the decision making process of convolutional networks, which is important both to improve models and to accelerate the adoption of such methods in e.g. medicine. In experiments on ImageNet data, we illustrate how the method works and can be applied in different ways to understand deep neural nets.
ChemInform Abstract: Synthesis of cis and trans Isomers of D‐Ring Linked Bis‐steroid Pyrazines from 16α‐Bromo‐17‐oxosteroids (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Optimizing Antihypertensive Therapy by Angiotensin Receptor Blockers (2006)

This chapter contains sections titled: Medicinal Chemistry Clinical Results with Angiotensin II Antagonists Mechanisms of Action Other Effects of ARBs Target Organ Protection Left Ventricular Hypertrophy Diabetic and Nondiabetic Nephropathy Diabetes Prevention Coronary Heart Disease (CHD) Congestive Heart Failure Stroke Prevention and Other CNS Effects Differences Among Angiotensin AT1 Receptor Blockers Structural Differences AT1 Receptor Antagonism Pharmacokinetics/Dosing Considerations Drug Interactions/Adverse Effects Efficacy in Hypertension Summary
Evaluating Fuel Flexibility in an IGCC Combustor Using CFD (2012)

Fuel flexibility and environmental performance are proving to be critically important to contemporary IGCC plants designed for various applications. Gas turbine combustion systems for IGCC power plants must have the capability to burn a variety of syngas compositions, including high hydrogen content, while maintaining low pollutant emissions and with high reliability. Evaluating an IGCC combustor for a wide range of fuels experimentally can be very expensive as a result of the cost of preparing the large quantities of synthesis gas required. CFD analysis permits many design options to be evaluated in a timely, cost-effective manner. This paper discusses the prediction of emission and combustor liner wall temperature distribution in an IGCC combustor for a wide range of fuels by using CFD. The prediction capability of laminar finite rate and laminar flamelet approaches have been analyzed on two full scale IGCC combustors for different H2/CO ratios. The CFD analysis on full scale IGCC combustor revealed that LFR approach were able to predict the liner wall temperature distribution and emission in good agreement with the lab compared to the LFM approach.
ChemInform Abstract: Carbons as Supports for Industrial Precious Metal Catalysts (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
La Induced Passivation of High-<i>k</i>Bulk and Interface Defects in Polycrystalline Silicon/TiN/HfLaSiO/SiO<sub>2</sub>Stacks (2011)

La incorporation into Hf-based gate dielectrics is a promising methodology for achieving low threshold voltage (Vth) metal/high-k n-channel metal–oxide–semiconductor field-effect transistors (nMOSFETs) with the gate-first process. To clarify the impact of the Hf/La ratio in high-k dielectrics on device performance, we investigated high-k bulk and interface traps of polycrystalline silicon (poly-Si)/TiN/HfLaSiO/SiO2 stacks with various Hf/La ratios. We found that La incorporation is effective for improving electron mobility; however, in a pure LaSiO device, the mobility is degraded. Our charge-pumping (CP) measurements revealed that both high-k bulk traps and near-interface traps (Nit) near the conduction band, which cause mobility degradation, can be effectively passivated by La incorporation. These results imply that an optimized La ratio will lead to superior nMOSFET performance, while an appropriate Vth can be tuned.
Poly(U) RNA-templated synthesis of AppA (2015)

Simple nucleotide templating activities are of interest as potential primordial reactions. Here we describe the acceleration of 5'-5' AppA synthesis by 3'-5' poly(U) under normal solution conditions. This reaction is apparently templated via complementary U:A base-pairing, despite the involvement of two different RNA backbones, because poly(U), unlike other polymers, significantly stimulates AppA synthesis. These interactions occur in moderate (K(+)) and (Mg(2+)) and are temperature sensitive, being more efficient at 10°C than at 4°C, but absent at 20°C. The reaction is only slightly pH sensitive, despite potentially relevant substrate pKa's. Kinetic data explicitly support production of AppA by interaction of stacked 2MeImpA and pA nucleotides paired with a single molecule of U template. At a lower rate, AppA can also be produced by a chemical reaction between 2MeImpA and pA, without participation of poly(U). Molecular modeling suggests that 5'-5' joining between stacked or concurrently paired A's can occur without major departures from normal U-A helical coordinates. So, coenzyme-like 5'-5' purine dinucleotides might be readily synthesized from 3'-5' RNAs with complementary sequences.
Dentin bonding performance of experimental one-step adhesives after incorporation of POOH–SiO2 nanoparticles (2016)

This study investigated the effect of adding different concentrations of phosphate-grafted-silica nanoparticles (SiO2–POOH) on dentin bond strength of experimental one-step self-etching adhesives (1-SEAs). Phosphate functional group was grafted onto silica nanoparticles through the free radical polymerization of an acid phosphate monomer [methacryloyloxyethyl dihydrogen phosphate/bis (methacryloyloxyethyl) hydrogen phosphate—HEMA-P] in an alcoholic medium. The resulting SiO2–POOH was characterized by FTIR spectroscopy. 1-SEA with two different acidic phosphate monomer concentrations (HEMA-P at 0 and 40% wt) were prepared and SiO2–POOH was added in 0 (control), 0.1, 0.2, 0.5, 1, 2, 4, 6 and 8wt%. The formulated 1-SEAs were evaluated for shear bond strength to dentin. Statistical comparisons were conducted at 5% significance level. The grafting reaction of SiO2–POOH was confirmed by FTIR. Compared with the unfilled 1-SEA, the addition of 0.1wt% of SiO2–POOH nanoparticles resulted in a significant dentin bond strength increase for HEMA-P40% concentration (p ≤ 0.001) while the addition of higher concentration of SiO2–POOH (0.2, 0.5, 1, 2, 4, 6 and 8wt%) reduced significantly the bond strength. The 1-SEA formulated without an acidic monomer (HEMA-P0%) did not exhibit bonding to the dentin, irrespective of SiO2–POOH concentration added. SiO2–POOH nanoparticles were obtained through graft polymerization of acidic phosphate monomer with silanized SiO2 nanoparticles. The addition of the 0.1wt% of SiO2–POOH nanoparticles associated with acidic monomer to 1-SEA improves the bonding effectiveness.
Proceedings of the 11th ACM Conference on Emerging Networking Experiments and Technologies (2015)

The importance of minimizing flow completion times (FCT) in datacenters has led to a growing literature on new network transport designs. Of particular note is pFabric, a protocol that achieves near-optimal FCTs. However, pFabric's performance comes at ...
The Concept of the Shapley Value and the Cost Allocation Between Cooperating Participants (2017)

The goal of this chapter is to illustrate two mathematical game theory concepts for allocating costs (savings) between cooperating participants, specifically in healthcare settings. These concepts are the nucleolus and the Shapley value. The focus of this chapter is on the practical application of the Shapley value for the cost sharing within the bundled payments model for the episodes of care mandated recently by the Center for Medicare Services (CMS). The general Shapley value methodology is illustrated, as well as an important particular case in which each participant uses only a portion of the largest participant's asset (the so-called airport game). The intended readers are primarily leaders of organizations and hospitals involved in the implementation of the CMS mandated bundled payment model for the episodes of care.
A Bayesian based EDA tool for accurate VLSI reliability evaluations (2008)

As the sizes of (nano) device are aggressively scaled deep towards the nanometer regime, the design and manufacturing of future nano-circuits will become extremely complex and inevitably introduce more defects and their functioning will be adversely affected by transient faults. Therefore, accurately calculating the reliability of future designs will become a very important factor for nano-circuit designers as they investigate several design alternatives to optimize the trade-offs between the conflicting metrics of area-power-energy-delay versus reliability. This paper introduces a novel EDA tool for accurate calculation of future nano-circuits reliabilities. Our aim is to provide both educational and research institutions (as well as the semiconductor industry at a later stage) with an accurate and easy to use tool for comparing the reliability of different design alternatives, and for selecting the design that best fits a set of given (design) constraints.
Fabrication of Organic Monolayer Modified Ion-Sensitive Field Effect Transistors with High Chemical Durability (2003)

Fabrication of ion-sensitive field effect transistor (FET) with modified SiO2 gate by various organosilane monolayers was investigated. By precise control of the fabrication processes, the FETs modified with various functional monolayers were successfully formed on the same substrate. Each modified device indicates typical transistor property with a good stability in aqueous solution. The transistor with amino monolayer modified gate showed good pH sensitivity of 58 mV/pH, whereas the profiles of transistor with the perfluoro-alkyl monolayer modified gate kept constant in any pH solutions. These monolayer-modified devices are expected to be applied as an ion-sensitive and a reference electrode for sensing devices in the solution.
<i>PAPSS2</i>‐related brachyolmia: Clinical and radiological phenotype in 18 new cases (2019)

Brachyolmia is a skeletal dysplasia characterized by short spine-short stature, platyspondyly, and minor long bone abnormalities. We describe 18 patients, from different ethnic backgrounds and ages ranging from infancy to 19 years, with the autosomal recessive form, associated with PAPSS2. The main clinical features include disproportionate short stature with short spine associated with variable symptoms of pain, stiffness, and spinal deformity. Eight patients presented prenatally with short femora, whereas later in childhood their short-spine phenotype emerged. We observed the same pattern of changing skeletal proportion in other patients. The radiological findings included platyspondyly, irregular end plates of the elongated vertebral bodies, narrow disc spaces and short over-faced pedicles. In the limbs, there was mild shortening of femoral necks and tibiae in some patients, whereas others had minor epiphyseal or metaphyseal changes. In all patients, exome and Sanger sequencing identified homozygous or compound heterozygous PAPSS2 variants, including c.809G>A, common to white European patients. Bi-parental inheritance was established where possible. Low serum DHEAS, but not overt androgen excess was identified. Our study indicates that autosomal recessive brachyolmia occurs across continents and may be under-recognized in infancy. This condition should be considered in the differential diagnosis of short femora presenting in the second trimester.
Identification paramétrique d'un alternateur : validation d'une méthodologie en simulation (2003)

National audience
Chemopreventive effect of the aromatase inactivator exemestane in the dimethylbenzanthracene (DMBA)-induced mammary tumors in rats (2004)

3108 Background: Exemestane (E, Aromasin) is an aromatase inactivator indicated for the treatment of advanced breast cancer (BC) and under evaluation for early BC. Methods: We have investigated the chemopreventive effect of E in the DMBA-induced mammary tumor in rats, an estrogen-dependent BC model. Tumors were induced by a single oral dose of DMBA (20 mg/rat). One week later animals were divided in five groups (20–22 animals/group): controls, E given weekly IM as a depot formulation at three dose levels (4, 20 or 100 mg/kg/week for 19 weeks) and ovariectomy (OVX). Control and OVX animals received the correspondent vehicle given IM, weekly for 19 weeks. Animals were palpated for tumor formation every week. Results: The final body weight was unchanged at the two lower E doses and increased by 26% and 21% for E 100 mg/kg/week and OVX, respectively. The results on tumor incidence, multiplicity (mean number of tumor per rat), tumor burden and uterus weight are reported in the Table. At the highest dose of 100 mg/kg/week E markedly reduces tumor incidence, multiplicity and burden at the end of the study period, similarly as effective as OVX. E causes a slight reduction in uterus weight only at the intermediate dose of 20 mg/kg/week. Conclusions: These data indicate that E is an active BC chemopreventive agent in an animal model. A 3-arm chemoprevention study using E +/- celecoxib vs placebo in post-menopausal women at risk is underway. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Pharmacia Italia
The <i>ham-2</i> Locus, Encoding a Putative Transmembrane Protein, Is Required for Hyphal Fusion in <i>Neurospora crassa</i> (2002)

Somatic cell fusion is common during organogenesis in multicellular eukaryotes, although the molecular mechanism of cell fusion is poorly understood. In filamentous fungi, somatic cell fusion occurs during vegetative growth. Filamentous fungi grow as multinucleate hyphal tubes that undergo frequent hyphal fusion (anastomosis) during colony expansion, resulting in the formation of a hyphal network. The molecular mechanism of the hyphal fusion process and the role of networked hyphae in the growth and development of these organisms are unexplored questions. We use the filamentous fungus Neurospora crassa as a model to study the molecular mechanism of hyphal fusion. In this study, we identified a deletion mutant that was restricted in its ability to undergo both self-hyphal fusion and fusion with a different individual to form a heterokaryon. This deletion mutant displayed pleiotropic defects, including shortened aerial hyphae, altered conidiation pattern, female sterility, slow growth rate, lack of hyphal fusion, and suppression of vegetative incompatibility. Complementation with a single open reading frame (ORF) within the deletion region in this mutant restored near wild-type growth rates, female fertility, aerial hyphae formation, and hyphal fusion, but not vegetative incompatibility and wild-type conidiation pattern. This ORF, which we named ham-2 (for hyphal anastomosis), encodes a putative transmembrane protein that is highly conserved, but of unknown function among eukaryotes.