gebhart/patrepeval huggingface dataset:
DIB-R++: Learning to Predict Lighting and Material with a Hybrid Differentiable Renderer (2021)

We consider the challenging problem of predicting intrinsic object properties from a single image by exploiting differentiable renderers. Many previous learning-based approaches for inverse graphics adopt rasterization-based renderers and assume naive lighting and material models, which often fail to account for non-Lambertian, specular reflections commonly observed in the wild. In this work, we propose DIBR++, a hybrid differentiable renderer which supports these photorealistic effects by combining rasterization and ray-tracing, taking the advantage of their respective strengths -- speed and realism. Our renderer incorporates environmental lighting and spatially-varying material models to efficiently approximate light transport, either through direct estimation or via spherical basis functions. Compared to more advanced physics-based differentiable renderers leveraging path tracing, DIBR++ is highly performant due to its compact and expressive shading model, which enables easy integration with learning frameworks for geometry, reflectance and lighting prediction from a single image without requiring any ground-truth. We experimentally demonstrate that our approach achieves superior material and lighting disentanglement on synthetic and real data compared to existing rasterization-based approaches and showcase several artistic applications including material editing and relighting.
Abstract 16564: Analysis of the Mechanisms of Intravenous Immunoglobulin-Resistant Kawasaki Disease Using iPS Cell Technology (2014)

Introduction: Kawasaki disease (KD) is a systemic vasculitis of unknown origin. Although the treatment of intravenous immunoglobulin (IVIG) significantly resolves inflammation, 10-20% of KD patients have persistent or recurrent fever after the administration of IVIG, and IVIG-resistant patients have a particularly high risk of developing coronary artery abnormalities. Hypothesis: The mechanisms of IVIG-resistant KD have been analyzed using the patients’ leukocyte samples. However, vascular endothelial cells (ECs), closely related to the vasculitis of KD, have not been examined in the previous reports. We propose a hypothesis that ECs are mainly involved in the etiology of IVIG-resistance. Methods: The purpose of this study is to establish new in vitro disease models of vasculitis using induced pluripotent stem cell (iPSC) technology, and clarify the mechanisms of IVIG-resistance in KD. Dermal fibroblasts or T cells from 2 IVIG-resistant and 2 IVIG-responsive KD patients were reprogrammed by episomal vectors encoding Oct3/4, Sox2, Klf4, L-Myc, LIN28, and p53 shRNA. The iPSC lines were then differentiated into ECs by using a previously-reported differentiation method, and the EC samples were subjected to the microarray analyses. Results: The KD patient-derived iPSCs could be differentiated into ECs. The gene expression profiles were compared between iPS-derived ECs (iPS-ECs) generated from IVIG-resistant and IVIG-responsive KD patients. We found that 107 genes were at least two fold up-regulated and 101 genes were at least two fold down-regulated in iPS-ECs from IVIG-resistant KD patients compared with those from IVIG-responsive patients. The Principle Component Analysis (PCA) was performed, but the gene expression levels showed no significant differences between the groups. The Gene Set Enrichment Analysis (GSEA) revealed that the gene sets related to IL-6, NRAS (a member of the RAS oncogene family) and breast cancer were up-regulated in iPS-ECs from IVIG-resistant KD patients. Conclusions: Taking into account that the concentration of IL-6 has been reported to be elevated in acute phase of IVIG-resistant KD, our results suggest that the up-regulation of IL-6 related genes in ECs might be involved in the pathogenesis of IVIG-resistant KD.
Supplementary Figures S1-S2 from Resistance to Chemotherapy Is Associated with Fibroblast Growth Factor Receptor 4 Up-Regulation (2023)

Supplementary Figures S1-S2 from Resistance to Chemotherapy Is Associated with Fibroblast Growth Factor Receptor 4 Up-Regulation
Study of Automatic GPU Offloading Technology for Open IoT (2018)

IoT technologies have been progressed. Now Open IoT concept has attracted attentions which achieve various IoT services by integrating horizontal separated devices and services. For Open IoT era, we have proposed the Tacit Computing technology to discover the devices with necessary data for users on demand and use them dynamically. However, existing Tacit Computing does not care about performance and operation cost. Therefore in this paper, we propose an automatic GPU offloading technology as an elementary technology of Tacit Computing which uses Genetic Algorithm to extract appropriate offload loop statements to improve performances. We evaluate a C/C++ matrix manipulation to verify effectiveness of GPU offloading and confirm more than 35 times performances within 1 hour tuning time.
Soil clay&amp;#x96;humus complexes. II. Bridging cations and DTA studies (2002)

Clay-humus complexes, isolated from 5 soils (Entisol, Alfisol, Vertisol, two Mollisols), were extracted with 0.1 n citrate, EDTA, and oxalate at pH 7.0-10.0; amounts of Ca2+, Mg2+, Fe3+/2+, Al3+, as well as humic acid (HA) in the extract were determined. HA extracted increased with pH and varied with nature of ligand; largest amounts were extracted by EDTA at high pH. In the Entisol clay-humus extract, Ca2+ is dominant. In Alfisol sample, Ca2+ and Mg2+ have little role in clay-HA bonding; apart from monovalent cations, bonding is mainly through Fe3+/2+ and Al3+, which are well correlated to HA extracted. The extract from Vertisol sample contains little Fe3+/2+ or Al3+ and major bonding is through Ca2+. In Mollisol I and II, Ca2+, Mg2+, Fe3+/2+,and Al3+ are all involved in bonding and are highly correlated to extracted HA. Difference in mineralogy determines the difference in bonding strength between Alfisol and Vertisol complexes. DTA indicates dual bonding modes. A major fraction of HA (in clay-humus complexes) shows thermal destabilisation due to multiple attachments on the clay surface; a small fraction is also thermally stabilised by ionic bonding with Ca2+/Mg2+ and absence of ring strain in the complex. Only the Alfisol HA does not show thermal stabilisation in the complex.
A matched-pair study comparing whole-brain irradiation alone to radiosurgery or fractionated stereotactic radiotherapy alone in patients irradiated for up to three brain metastases (2017)

In this matched-pair study, RS/FSRT alone was not superior to WBI alone regarding IC and OS. These results can be considered a revision of the findings from our retrospective previous study without matched-pair design, where RS alone resulted in significantly better IC than WBI alone on multivariate analysis.
Device-to-Device extension to Geometry-based Stochastic Channel Models (2015)

Increased interest towards direct Device-to-Device (D2D) radio communication has led to questions about the validity of standardised Geometry-based Stochastic Channel Models (GSCMs). D2D sets new requirements to channel models due to the different usage scenarios and different propagation environments. This paper discusses extensions to GSCMs for fulfilling the new requirements such as dual-mobility, spatial consistency, and lower antenna height compared to base stations. By using the sum of sinusoids method, significant savings on memory consumption can be achieved.
Near-optimality of the one-step max-sum-rate precoder with MMSE initialization for large downlink multi-user MIMO systems (2014)

Our recent study demonstrated that an iterative max-sum-rate (MSR) precoder with MMSE initialization gives an excellent sum-rate performance in downlink multi-user MIMO systems. As the number of transmit antennas increases, two crucial remarks were made: (1) its performance approaches the dirty-paper coding upper-bound and (2) the one-step iteration gives a decent performance. In this paper first, we further illustrate the second observation by looking at the optimality of this one-step max-sum-rate precoder with MMSE initialization (MSR-MMSE-1) for large MIMO systems. This shows that we can get near-optimal performance of the iterative MSR precoder without having to deal with any iteration at all. Then, we compare its sum-rate performance against one from the well-known block diagonalization algorithm (BD). Again, it is found that, when the number of transmit antennas is large enough, MSR-MMSE-1 outperforms BD across all SNR values under consideration.
Lack of Toxicity in Nonhuman Primates Receiving Clinically Relevant Doses of an AAV9.U7snRNA Vector Designed to Induce <i>DMD</i> Exon 2 Skipping (2021)

Therapeutic exon skipping as a treatment for Duchenne muscular dystrophy (DMD) has largely concentrated on the delivery of antisense oligomers to treat out-of-frame exon deletions. Here we report on the preclinical development of an adeno-associated virus (AAV)-encapsidated viral vector containing four copies of the noncoding U7 small nuclear RNA (U7snRNA), each targeted to either the splice donor or the splice acceptor sites of <i>DMD</i> exon 2. We have previously shown that delivery of this vector (scAAV9.U7.ACCA) to the Dup2 mouse model results in expression of full-length dystrophin from wild-type <i>DMD</i> mRNA, as well as an internal ribosome entry site (IRES)-driven isoform translated only in the absence of exon 2 (deletion exon 2 [Del2] mRNA). Here we present the data from a rigorous dose escalation toxicity study in nonhuman primates, encompassing two doses (3 × 10<sup>13</sup> and 8 × 10<sup>13</sup> vg/kg) and two time points (3 and 6 months postinjection). No evidence for significant toxicity was seen by biochemical, histopathologic, or clinical measures, providing evidence for safety that led to initiation of a first-in-human clinical trial.
Improving Competitiveness of Engineering Students With Disabilities Through Focused Learning (2016)

On many university campuses, students with disabilities form a noticeable group of the student population. Over the past years, enrollment of students with disabilities has markedly increased and this trend is expected to continue in the future. Although students with disabilities often prefer to major in non-technical areas, a considerable number of them choose to seek career opportunities in science, engineering and technology. The majority of prior studies on educating special engineering and STEM students have been oriented towards students with physical disabilities. A balanced approach is advocated in which individual aspects of the disability are given a special consideration and learning strategies and the environment are tailored in accordance with student’s needs. Such adjustments are critical in accommodating students with a wide spectrum of disabilities. The aim of this paper is to consider various aspects of engineering education that may improve the competitiveness of engineering students with disabilities when they enter the professional workforce.
52-kDa Ro/SSA epitopes preferentially recognized by antibodies from mothers of children with neonatal lupus and congenital heart block (2005)

Neonatal lupus erythematosus is a rare disorder caused by the transplacental passage of maternal autoantibodies. The 52-kDa Ro/SSA antigen (Ro52) ribonucleoprotein represents an antigenic target strongly associated with the autoimmune response in mothers whose children have neonatal lupus and cardiac conduction disturbances, mainly congenital heart block. The objective of this study was to identify putative Ro52/60-kDa Ro/SSA antigen (Ro60) epitopes associated with neonatal lupus and congenital heart block. The reactivity of IgG antibodies present in the sera from mothers with systemic lupus erythematosus and Sjögren's syndrome and in the sera from asymptomatic mothers (a longitudinal study of 192 samples from 66 subjects) was investigated by ELISA using Ro52, Ro60 and 48-kDa La/SSB antigen proteins, as well as 45 synthetic peptides, 13-24 residues long, of Ro52/Ro60 proteins. One to 19 samples collected before, during and after pregnancy were available for each mother. Forty-three disease controls selected randomly and normal sera were tested in parallel. Although no differences were found between Sjögren's syndrome and asymptomatic mothers of group I, who had at least one infant with neonatal lupus, and of group II, who had healthy babies only, significant differences were observed between lupus mothers from both groups. In the former group of lupus mothers, a significantly higher frequency of antibodies to Ro52 peptides 107-122 and 277-292 was observed. Between 18 and 30 weeks of gestation, the period of risk, there was clearly an elevated level of antibodies reacting with Ro52 peptides 1-13, 277-292 and 365-382. Antibodies to Ro52 peptide 365-382 have been shown previously to cross-react with residues 165-185 of the heart 5-HT4 serotoninergic receptor, and might be pathologically important. The level of these Ro52 antibody subsets decreased at the end of pregnancy and after delivery. IgG antibodies to Ro52 peptides 1-13, 107-122, 277-292 and 365-382 may therefore represent important biomarkers to predict a complication in pregnant lupus women with Ro52 antibodies.
Microwave assisted synthesis of 2-amino-4-chloro-pyrimidine derivatives: Anticancer and computational study on potential inhibitory action against COVID-19 (2022)

We report microwave synthesis of seven unique pyrimidine anchored derivatives (<b>1</b>-<b>7</b>) incorporating multifunctional amino derivatives along with their <i>in vitro</i> anticancer activity and their activity against COVID-19 in silico. <b>1</b>-<b>7</b> were characterized by different analytical and spectroscopic techniques. Cytotoxic activity of <b>1</b>-<b>7</b> was tested against HCT116 and MCF7 cell lines, whereby <b>6</b> exhibited highest anticancer activity on HCT116 and MCF7 with EC<sub>50</sub> values of 89.24 ± 1.36 µM and 89.37 ± 1.17 µM, respectively. Molecular docking was performed for derivatives (<b>1</b>-<b>7</b>) on main protease for SARS-CoV-2 (PDB ID: 6LU7). Results revealed that most of the derivatives had superior or equivalent affinity for the 3CLpro, as determined by docking and binding energy scores. <b>6</b> topped the rest with highest binding energy score of -8.12 kcal/mol with inhibition constant reported as 1.11 µM. ADME, drug-likeness, and pharmacokinetics properties of <b>1</b>-<b>7</b> were tested using Swiss ADME tool. Toxicity analysis was done with pkCSM online server. All derivatives showed high GI absorption. Except <b>1</b> and <b>3</b>, all derivatives showed blood brain barrier permeability. Most derivatives showed negative logKp values suggesting derivatives are less skin permeable and bioavailability score of all derivatives was 0.55. The toxicity analysis demonstrated that all derivatives have no skin sensitization properties. <b>6</b> and <b>7</b> showed maximum tolerated dose (Human) values of -0.03 and -0.018, respectively and absence of AMES toxicity.
Paclitaxel loaded poly (DL lactic acid co castor oil) 60:40 with poloxamer‐F68 rod shape cylindrical nanoparticle preparation and in vitro cytotoxicity studies (2019)

This research presents a thin‐film hydration‐solvent evaporation method to formulate the paclitaxel loaded poly (DL lactic acid co castor oil) 4:6 with poloxamer‐F68 cylindrical shape nanoparticles. The particles were less than 250 nanometers (nm) in size, with an average width of 60 nm and an average length of 100 nm. The percent yield, encapsulation efficiency (EE), and percent drug loading (DL) were detected. This approach produces drug loading values between 5% and 20% w/w. X‐ray powder diffraction (XRD) identified the physicochemical properties of nanoparticles differential scanning calorimetry (DSC) and Fourier‐transform infrared spectroscopy (FTIR). The investigation shows that the drug is molecularly dispersed in polymers or given in an amorphous or semicrystalline state. Horizontal water bath shaker technology considered the in vitro release of PTX loaded nanoparticles under sink conditions. Poly (DL lactic acid co castor oil) 4:6 nanoparticles exhibited a sustained release analysis. At the end of 30 hours, the percent cumulative drug release from the formulations was between 74.52% and 92.87% for F1 and F4. In vitro cytotoxicity assays indicate that PTX having p (DLLA:CO60:40) nanoparticles have a higher cytotoxic effect on MCF‐7/ADR.
5mJ pulsed Yb-doped all-fiber MOPA seeded by 0.2nm spectrally sliced super luminescent diode (2015)

Fiber MOPA system utilizing large core Yb-doped gain fiber to produce 100Hz repetition frequency 100ns, 5mJ rectangular pulses by amplification of shaped seed pulses from 0.2nm band pass filtered Super Luminescent Diode emission, is demonstrated.
Media Aware OverlayRouting in Ambient Networks (2005)

Withtheincreasing heterogeneity ofInternet enabled devices andInternet access technologies, mediacontent mayoften needtobeadapted tobest meettheuserorapplication needs.However, server-side adaptation hasshownits limitations, leading to thedevelopment of netvork-side adaptation techniques. Overlay Networks haveemerged asa possible solution toenable dataprocessing between usersand thecontent server, asitallows totransparently include media processing nodes into theend-to-end mediapath. Nevertheless, todealwithmultimedia streams inanefficient way,current proposals lackapplication awareness whenitcomestorouting decisions. Typically overlay networks onlyconsider IPheader information whenrouting packets. Inthis paper weintroduce a newconcept that shall enable mediaawarerouting viatheuseof overlay networks. Theproposed routing approach considers service andapplication information toimprove routing decisions basedontheuser/application requirements. Inourproposal, service-specific overlay networks (SSONs) arecreated forevery service, whichallows customisation ofthenetwork resources. SSONsinclude overlay nodeswithadaptation capability. The datarouting intheSSONisperformed using themediaaware overlay routing logic. Thispaperpresents theconcept, along withaproposed architecture designed toprovide amedia aware routing service. Theadvantage oftheproposed functionality is illustrated based onamobile userscenario. IndexTerms-Overlay networks, ContentAdaptation. NetworkProcessing, Adaptive NetworkTechnologies, Media Awareness, MediaRouting.
Praxisorientierte Optimierung der rheologischen Eigenschaften von UHPC (2014)

Ultra-Hochfeste Betone (UHPC) zeichnen sich in erster Linie durch ihre sehr hohe Festigkeit sowie die sehr guten Dauerhaftigkeitseigenschaften auf. Moglich wird dies durch sehr geringe w / z-Werte und hohe Anteile mehlfeiner
Zusatzstoffe. Zur Verbesserung der Verarbeitungs-eigenschaften werden daher in der Regel hohe Gehalte an Fliesmitteln verwendet. Diese konnen insbesondere die Fliesgrenze deutlich reduzieren. Die Viskositat bleibt hingegen sehr hoch, was mit einer schlechten Verarbeitbarkeit und Entluftungsfahigkeit des Betons einhergeht.
Der Beitrag beschaftigt sich mit der Rheologie Ultra-Hochfester Betone. Zum einen werden Mindestanforderungen an die plastische Viskositat und die Fliesgrenze der UHPC festgelegt, um eine ausreichende Formfullung in Abhangigkeit der geometrischen Randbedingungen minimaler Bauteilquerschnitt
und Schlankheit eines Bauteils sicher zu gewahrleisten. Zum
anderen wird gezeigt, wie die Rheologie eines UHPC gezielt durch die Wahl der Zusatzstoffe beeinflusst werden kann, um ein optimiertes Formfullungsvermogen zu erreichen. Zu diesem Zweck wurden Untersuchungen zur Bestimmung der rheologischen Eigenschaften im Rotationsrheometer mit
Formfullungsversuchen in charakteristischen Modellschalungen kombiniert.
Analytical Validation of Digital Spatial Profiling - a novel approach for multiplexed characterization of protein distribution and abundance in FFPE tissue sections (2018)

Abstract Nanostring Technologies’ Digital Spatial Profiling (DSP) technology allows for the simultaneous analysis of 10’s to 100’s of proteins from discrete regions of interest (ROI), providing a morphological context to multiplexed protein analysis. The purpose of this study is to validate an antibody panel designed to characterize key immunology and tumor markers on the DSP platform. IHC was performed on human FFPE tissues and human cell line pellets to evaluate binding specificity in both unconjugated and oligo-conjugated antibodies. The dynamic range of antibodies was tested using positive and negative FFPE cell pellets at different ratios. Interaction screens were performed to evaluate potential effects of multiplexing antibodies. A tissue microarray (TMA) containing normal and cancer tissues was employed to assess assay robustness. IHC analysis of antibodies displayed indistinguishable staining patterns for both unconjugated and oligoconjugated antibodies. Mixed-proportion cell pellet assays revealed strong correlations between positive counts and positive cell numbers in an ROI. For example, CD3 displayed a LOD of 4% when assayed using cell pellet mixtures containing CD3+ CCRF-CEM cells and CD3− HEK293T cells. Interaction studies showed similar values for antibodies alone or in combination (R2 &amp;gt; 0.8). TMA hierarchical clustering analysis demonstrated expected patterns for immune and tumor cells across different tissues. These results demonstrate that indexing oligo conjugation does not interfere with antibody specificity and that these conjugated antibodies are robust reagents for quantification of protein abundance. Continued work on the DSP platform will expand the library of antibodies accessible for profiling.
Strontium Niobate for Near Infrared Plasmonics (2019)

We study Strontium Niobate (SNO) as an alternate material for plasmonics in the near infrared wavelength range. We demonstrate, experimentally and through numerical simulations, hybrid plasmonic-photonic resonances in a SiO 2 -Si nanodisk stack on SNO near technologically important telecommunication wavelengths window.
Influence of temperature and spawning effort on <i>Haliotis tuberculata</i> mortalities caused by <i>Vibrio harveyi</i>: an example of emerging vibriosis linked to global warming (2009)

Abstract Since 1998, Haliotis tuberculata mass mortalities have been occurring regularly in wild abalone populations in France during their reproductive period and in conjunction with seawater summer temperature maxima and Vibrio harveyi presence. To confirm the importance of bacterial exposure, temperature and reproductive status on abalone susceptibility, experimental infections via bath exposure were performed using abalone ranging from immature to reproductively mature. Ripe abalone were more susceptible to the bacterium than immature specimens ( P &lt;0.001), and a difference of only 1 °C in temperature had a highly significant impact on the mortalities ( P &lt;0.001). The natural mortalities that were surveyed during summer 2007 confirmed that recent epidemic losses of European abalone appeared in conjunction with host reproductive stress, elevated temperatures and presence of the pathogen V. harveyi . In view of the elevation of the mean summer temperatures observed in Brittany and Normandy over the last 25 years, this temperature‐dependent vibriosis represents a new case of emerging disease associated with global warming.