gebhart/patrepeval huggingface dataset:
Dual‐broadband printed monopole antenna with a numeral‐7 slit (2009)

Abstract A 15‐by‐20‐mm 2 dual‐broadband printed monopole antenna fed by a coplanar waveguide is presented. With a numeral‐7 slit etched from the rectangular radiating element, the antenna can excite for its lower and upper impedance bands two and one resonant modes, respectively. With a back‐patch appropriately printed on the other side of the substrate, a lower (upper) impedance band with a bandwidth of 39.3% (19.5%) can be obtained. These two impedance bands can cover the frequency bands required by UMTS/IMT‐2000/IEEE802.11a/b/g/WiMAX. © 2009 Wiley Periodicals, Inc. Microwave Opt Technol Lett 51: 2544–2547, 2009; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.24677
New compact polarization rotator in anisotropic LiNbO_3 graded-index waveguide (2008)

The new compact polarization rotator in anisotropic graded index Ti:LiNbO(3) channel waveguide is proposed and investigated by 3D beam propagation method (BPM). Device is based on a channel optical waveguide directed at small angle (about 5 degrees) with respect to Z-axis on Y-cut lithium niobate substrate. The polarization conversion from quasi-TE to quasi-TM guided modes (and backwards) along 8 mm long waveguide with an index contrast 0.015, has been numerically demonstrated. Device is intended for polarization diversity of integrated optic elements based on LiNbO(3) structures.
Electrophysiological changes in animal model of chronic cardiac failure (1990)

Shortening of ventricular repolarisation and refractory period in heart failure may represent an intrinsic mechanism predisposing to arrhythmia and sudden death.
Phase I trial of metronomic cyclophosphamide (CTX) and lenalidomide (LEN) in patients with castration-resistant prostate cancer (CRPC). (2012)

164 Background: Angiogenesis and suboptimal antitumor immune response are important in the progression of CRPC. Both LEN and metronomic CTX have known anti-angiogenic and immunomodulatory activities. A phase I study of a novel combination of metronomic CTX with LEN in patients with CRPC who have failed prior docetaxel therapy was initiated to assess safety and effects on potential biomarkers. Methods: CTX was given 50 mg PO QD(day 1-28) and LEN 10-25 mg PO QD(day 1-21) on a 28 day cycle. Dose limiting toxicity was defined as any treatment-related grade 4 hematologic event or grade 3 / 4 non-hematologic event during cycles one. Quantification of circulating tumor cells (CTC), plasma cytokines, analgesic consumption and quality of life assessments were performed. Measurement of Treg and MDSCs were performed in some patients. Results: 17 patients with CRPC have been enrolled in L0-4; all patients are evaluable for toxicity. Patient characteristics include: ECOG performance status 0/1= 4/13; median age=77 (range 50–86); median PSA=36.7 (range 1.36–2287). Dose level 1 (CTX 50 mg/d, LEN 10 mg/d) was expanded to 6 patients after one out of three initial patients was removed from the study for Gr 3 gastrointestinal bleeding (in cycle 1). Dose level 1 (CTX 25 mg/d, LEN 10 mg/d) had no DLT’s. The maximum tolerated dose has not yet been reached. Other Grade 3/4 toxicities observed after cycle 1 included grade 3 pain (N=1), grade 3 neutropenia (N=4), grade 3 thrombocytopenia (N=2), grade 4 neutropenia (N=2). Most frequent grade 1 and 2 toxicities included anemia, fatigue, neutropenia, and hypocalcemia. Overall, 9 of 14 patients (64%) have experienced a reduction in PSA. One patient had partial response after one cycle. Stable disease was documented in 5 of 14 (36%) evaluable patients. Two inflammatory cytokines, IL-6 (N = 19; r = 0.64; p = 0.0035) and IL-8 (N = 9; r = 0.86; p = 0.0028), were found to significantly correlated with PSA. Conclusions: The combination of metronomic CTX and LEN can be safely administered. Preliminary clinical activity was observed in this heavily-pretreated patient population. Enrollment to this study continues and clinical and biomarker studies are ongoing.
Histone Deacetylase 6 Inhibitor JS28 Prevents Pathological Gene Expression in Cardiac Myocytes (2022)

Background Epigenetic modulators have been proposed as promising new drug targets to treat adverse remodeling in heart failure. Here, we evaluated the potential of 4 epigenetic drugs, including the recently developed histone deacetylase 6 (HDAC6) inhibitor JS28, to prevent endothelin-1 induced pathological gene expression in cardiac myocytes and analyzed the chromatin binding profile of the respective inhibitor targets. Methods and Results Cardiac myocytes were differentiated and puromycin-selected from mouse embryonic stem cells and treated with endothelin-1 to induce pathological gene expression (938 differentially expressed genes, q<0.05). Dysregulation of gene expression was at least in part prevented by epigenetic inhibitors, including the pan-BRD (bromodomain-containing protein) inhibitor bromosporine (290/938 genes), the BET (bromodomain and extraterminal) inhibitor JQ1 (288/938), the broad-spectrum HDAC inhibitor suberoylanilide hydroxamic acid (227/938), and the HDAC6 inhibitor JS28 (210/938). Although the 4 compounds were similarly effective toward pathological gene expression, JS28 demonstrated the least adverse effects on physiological gene expression. Genome-wide chromatin binding profiles revealed that HDAC6 binding sites were preferentially associated with promoters of genes involved in RNA processing. In contrast, BRD4 binding was associated with genes involved in core cardiac myocyte functions, for example, myocyte contractility, and showed enrichment at enhancers and intronic regions. These distinct chromatin binding profiles of HDAC6 and BRD4 might explain the different effects of their inhibitors on pathological versus physiological gene expression. Conclusions In summary, we demonstrated, that the HDAC6 inhibitor JS28 effectively prevented the adverse effects of endothelin-1 on gene expression with minor impact on physiological gene expression in cardiac myocytes. Selective HDAC6 inhibition by JS28 appears to be a promising strategy for future evaluation in vivo and potential translation into clinical application.
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver (2010)

The liver and pancreas share a common origin and coexpress several transcription factors. To gain insight into the transcriptional networks regulating the function of these tissues, we globally identify binding sites for FOXA2 in adult mouse islets and liver, PDX1 in islets, and HNF4A in liver. Because most eukaryotic transcription factors bind thousands of loci, many of which are thought to be inactive, methods that can discriminate functionally active binding events are essential for the interpretation of genome-wide transcription factor binding data. To develop such a method, we also generated genome-wide H3K4me1 and H3K4me3 localization data in these tissues. By analyzing our binding and histone methylation data in combination with comprehensive gene expression data, we show that H3K4me1 enrichment profiles discriminate transcription factor occupied loci into three classes: those that are functionally active, those that are poised for activation, and those that reflect pioneer-like transcription factor activity. Furthermore, we demonstrate that the regulated presence of H3K4me1-marked nucleosomes at transcription factor occupied promoters and enhancers controls their activity, implicating both tissue-specific transcription factor binding and nucleosome remodeling complex recruitment in determining tissue-specific gene expression. Finally, we apply these approaches to generate novel insights into how FOXA2, PDX1, and HNF4A cooperate to drive islet- and liver-specific gene expression.
Magnetic phase diagram of the hole-doped T' phases Nd2-xSrxCuO4-.delta. (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMagnetic phase diagram of the hole-doped T' phases Nd2-xSrxCuO4-.delta.Matthew J. Rosseinsky, Kosmas Prassides, and Christopher A. ScottCite this: Inorg. Chem. 1991, 30, 18, 3367–3370Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://pubs.acs.org/doi/10.1021/ic00018a002https://doi.org/10.1021/ic00018a002research-articleACS PublicationsRequest reuse permissionsArticle Views96Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
LLIMAS: Revolutionizing integrating modeling and analysis at MIT Lincoln Laboratory (2017)

MIT Lincoln Laboratory’s Integrated Modeling and Analysis Software (LLIMAS) enables the development of novel engineering solutions for advanced prototype systems through unique insights into engineering performance and interdisciplinary behavior to meet challenging size, weight, power, environmental, and performance requirements. LLIMAS is a multidisciplinary design optimization tool that wraps numerical optimization algorithms around an integrated framework of structural, thermal, optical, stray light, and computational fluid dynamics analysis capabilities. LLIMAS software is highly extensible and has developed organically across a variety of technologies including laser communications, directed energy, photometric detectors, chemical sensing, laser radar, and imaging systems. The custom software architecture leverages the capabilities of existing industry standard commercial software and supports the incorporation of internally developed tools. Recent advances in LLIMAS’s Structural-Thermal-Optical Performance (STOP), aeromechanical, and aero-optical capabilities as applied to Lincoln prototypes are presented.
Sub-10 nm Scale Nanostructures in Self-Organized Linear Di- and Triblock Copolymers and Miktoarm Star Copolymers Consisting of Maltoheptaose and Polystyrene (2015)

The present paper describes the sub-10 nm scale self-assembly of AB-type diblock, ABA-type triblock, and A2B-type miktoarm star copolymers consisting of maltoheptaose (MH: A block) and polystyrene (PS: B block). These block copolymers (BCPs) were synthesized through coupling of end-functionalized MH and PS moieties. Small-angle X-ray scattering and atomic force microscope investigations indicated self-organized cylindrical and lamellar structures in the BCP bulks and thin films with domain spacing (d) ranging from 7.65 to 10.6 nm depending on the volume fraction of MH block (ϕMH), Flory–Huggins interaction parameter (χ), and degree of polymerization (N). The BCP architecture also governed the morphology of the BCPs, e.g. the AB-type diblock copolymer (ϕMH = 0.42), the ABA-type triblock copolymer (ϕMH = 0.40), and the A2B-type miktoarm star copolymer (ϕMH = 0.45) self-organized into cylinder (d = 7.65 nm), lamellar (d = 8.41 nm), and lamellar (d = 9.21 nm) structures, respectively.
HIV Preexposure Prophylaxis Among Adolescents in the US (2020)

Use of PrEP in adolescents at risk for HIV is an important component of HIV prevention. Optimizing uptake includes improving clinicians' knowledge about HIV risk and prevention strategies, enhancing sexual history taking and risk assessment through training and retraining, and improving PrEP knowledge and acceptance of prescribing among clinicians. Leveraging the ubiquity of social media, encouraging family support, and performing research aimed at finding lifestyle-congruent formulations can help mitigate HIV transmission in adolescents at greatest risk for HIV.
Passive DC neutral breaker for bipolar HVDC schemes (2017)

DC neutral breakers are used to reconfigure HVDC transmission systems. One example is the Metallic Return Transfer Breaker (MRTB) that commutates the current from the ground to an overhead line or cable reducing time duration with current flowing in the ground path. An MRTB consists of a passive LC-circuit in parallel with an AC breaker that triggers a resonance by its arc voltage characteristics, that eventually gives a current zero crossing where the current is interrupted. Based on the trend with higher current ratings of HVDC systems, the MRTB performance also needs to be increased. In year 2000 the passive MRTB's could interrupt 2500 A [1], in 2014 performance of 5000 A was reported [2] and now performance has been validated to more than 6800 A. This paper describes how this performance increase has been achieved by careful design of the LC-circuit and validation in a high power lab.
&lt;title&gt;Characterization of elliptical-core side-hole fibers for interferometric pressure sensing&lt;/title&gt; (1994)

Results of preliminary testing of two newly developed highly birefringent fibers, especially designed for hydrostatic pressure sensing employing a white-light interferometric technique are presented. In particular, measurements of pressure and temperature sensitivities, temperature-pressure cross-sensitivity, and mode coupling effect induced by pressure and temperature are reported.
Thermoelectricity and localized f-band control by dp-hybridization on the Ce1−xCuxSe2 compounds (2010)

We measured the temperature-dependent thermal conductivity κ(T), Seebeck coefficient S(T), and electrical resistivity ρ(T) of the polycrystalline Ce1−xCuxSe2 (x=0.0, 0.1, 0.2, and 0.3) series compounds. The high temperature thermoelectric property measurements of Ce0.9Cu0.1Se2 have shown that the maximum thermoelectric figure-of-merit (ZT) reached up to 0.18 at 800 K due to the large Seebeck coefficient (S≈344 μV/K) and relatively low thermal conductivity (κ=0.71 W m−1 K−1). By increasing the Cu-doping concentration (x≥0.2), the ZT is lowered mainly due to increasing the thermal conductivity. From the band structure calculation, the high Seebeck coefficient for the Ce0.9Cu0.1Se2 compound is attributed to the localized Ce f-band near the Fermi level due to Cu d- and Se p-orbital hybridization. The localized f-band has been shifted to a higher energy from the Fermi level with increased Cu-doping concentration, which is consistent with the decrease in the Seebeck coefficient. This research proposes that the orbital hybridization control on the layered structure rare-earth dichalcogenides is promising for high ZT thermoelectric materials development.
New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15 (2006)

The unique coronavirus transcription/replication machinery comprised of multiple virus-encoded nonstructural proteins (nsp) plays a vital role during initial and intermediate phases of the viral life cycle. The crystal structure of mouse hepatitis virus strain A59 (MHV-A59) nsp15 is reported at 2.15-A resolution. nsp15 is an XendoU endoribonuclease and is the first one from this family to have its structure unveiled. The MHV-A59 nsp15 monomer structure has a novel protein fold. Two nsp15 trimers form a back-to-back hexamer that is believed to be the functional unit. The structure reveals the catalytic site including the highly conserved residues His262, His277, and Lys317, which is supported by mutagenesis analysis. Gel filtration and enzyme activity assays confirmed that the hexamer is the active form for nsp15 and demonstrate the specificity of nsp15 for uridylate. The high sequence conservation of nsp15 in coronaviruses, including that of severe acute respiratory syndrome, suggests that this protein may provide a new target for the design of antiviral therapeutics.
Figure S5 from An Fc-free EGFR-specific 4-1BB-agonistic Trimerbody Displays Broad Antitumor Activity in Humanized Murine Cancer Models without Toxicity (2023)

&lt;p&gt;Experimental and theoretical SAXS scattering.&lt;/p&gt;
4E-BP–Dependent Translational Control of <i>Irf8</i> Mediates Adipose Tissue Macrophage Inflammatory Response (2020)

Deregulation of mRNA translation engenders many human disorders, including obesity, neurodegenerative diseases, and cancer, and is associated with pathogen infections. The role of eIF4E-dependent translational control in macrophage inflammatory responses in vivo is largely unexplored. In this study, we investigated the involvement of the translation inhibitors eIF4E-binding proteins (4E-BPs) in the regulation of macrophage inflammatory responses in vitro and in vivo. We show that the lack of 4E-BPs exacerbates inflammatory polarization of bone marrow-derived macrophages and that 4E-BP-null adipose tissue macrophages display enhanced inflammatory gene expression following exposure to a high-fat diet (HFD). The exaggerated inflammatory response in HFD-fed 4E-BP-null mice coincides with significantly higher weight gain, higher <i>Irf8</i> mRNA translation, and increased expression of IRF8 in adipose tissue compared with wild-type mice. Thus, 4E-BP-dependent translational control limits, in part, the proinflammatory response during HFD. These data underscore the activity of the 4E-BP-IRF8 axis as a paramount regulatory mechanism of proinflammatory responses in adipose tissue macrophages.
Zur Reaktion zwischen Bis (dimethylamino)acetonitril und Phenylisocyanat. Vorläufige Mitteilung (1980)

On the Reaction of Bis(dimethylamino)acetonitrile with Phenylisocyanate Bis(dimethylamino)acetonitrile (1) reacts with phenylisocyanate to yield the imidazolidinedione 2 , as confirmed by X‐ray structure analysis. The mechanism of formation of 2 is discussed.
Measurement of a high-gain antenna at 650 GHz in a hologram-based CATR (2007)

A hologram-based compact antenna test range (CATR) at 650 GHz was designed, constructed, and used for testing the ADMIRALS RTO antenna of 1.5 m in diameter. The CATR is based on a 3.16-meter computer-generated amplitude hologram. Ordinary floor carpets with good absorbing and scattering properties were used as absorbers in the measurement room. Introduction Functional prior-launch end-to-end tests of sub-millimeter wave antennas are vital for reliable satellite missions. However, testing of the electrically large reflector antennas is an extremely challenging task. The required far-field distance becomes easily very large at sub-millimeter wavelenghts. For example, the typical requirement 2D/λ gives about 9.8 km far-field distance for a 1.5 m antenna at 650 GHz. Therefore, far-field measurements are in practice impossible because of the atmospheric effects. Near-field measurements are technically very complicated and expensive requiring a high-accuracy scanner and a very stable RF-measurement system. Conventional compact antenna test range (CATR) measurements, although performed up to 500 GHz [1], are problematic due to high surface accuracy requirement of the reflectors; typical requirement is the surface accuracy better than 0.01λ, corresponding to 4.6 μm at 650 GHz. In the hologram CATR, the needed plane wave is created with the use of a computer-generated binarized amplitude hologram [2]. The hologram pattern can be determined numerically by calculating the structure required to change the known input field (radiation pattern of the feed) into the desired output field (plane wave) [3]. The pattern is realized on a metal layer that is on top of a dielectric substrate. As a transmission type of element, the hologram planarity requirements are less stringent than those of a reflector. Thus, hologram CATR has a great potential in submillimeter wave antenna measurements [4,5,6,7]. Design and construction of a hologram-based CATR for 650 GHz We designed a hologram CATR, Figs. 1 and 2, aiming at 650-GHz tests of the Planck RFQM 1.5-m antenna. However, as the Planck RFQM was not available, we ended up using an alternative test object with the same antenna size, namely the ADMIRALS RTO from EADS Astrium. The hologram was made of three pieces, which were joined by soldering to form the final 3.16 m hologram. A proper illumination of the hologram was facilitated using a dual reflector feed system (DRFS) [8]. For quiet-zone testing, a planepolar type scanner was designed with a linear stage allowing linear scans of about 2.5 m in four orientations: horizontal, vertical, and two diagonals. The measured peak-to-peak 18th International Symposium on Space Terahertz Technology
microRNA 17/20 inhibits cellular invasion and tumor metastasis in breast cancer by heterotypic signaling (2010)

microRNAs are thought to regulate tumor progression and invasion via direct interaction with target genes within cells. Here the microRNA17/20 cluster is shown to govern cellular migration and invasion of nearby cells via heterotypic secreted signals. microRNA17/20 abundance is reduced in highly invasive breast cancer cell lines and node-positive breast cancer specimens. Cell-conditioned medium from microRNA17/20-overexpressing noninvasive breast cancer cell MCF7 was sufficient to inhibit MDA-MB-231 cell migration and invasion through inhibiting secretion of a subset of cytokines, and suppressing plasminogen activation via inhibition of the secreted plasminogen activators (cytokeratin 8 and alpha-enolase). microRNA17/20 directly repressed IL-8 by targeting its 3' UTR, and inhibited cytokeratin 8 via the cell cycle control protein cyclin D1. At variance with prior studies, these results demonstrated a unique mechanism of how the altered microRNA17/20 expression regulates cellular secretion and tumor microenvironment to control migration and invasion of neighboring cells in breast cancer. These findings not only reveal an antiinvasive function of miR-17/20 in breast cancer, but also identify a heterotypic secreted signal that mediates the microRNA regulation of tumor metastasis.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling of Potassium Alkoxyethyltrifluoroborates: Access to Aryl/Heteroarylethyloxy Motifs. (2013)

Abstract A robust, scalable, and efficient method allows an easy installation of an alkoxyethyl unit on a broad range of aryl and heteroaryl bromides.