gebhart/patrepeval huggingface dataset:
Microarchitectural power modeling techniques for deep sub-micron microprocessors (2004)

The need to perform early design studies that combine architectural simulation with power estimation has become critical as power has become a design constraint whose importance has moved to the fore. To satisfy this demand several microarchitectural power simulators have been developed around SimpleScalar, a widely used microarchitectural performance simulator. They have proven to be very useful at providing insights into power/performance trade-offs. However, they are neither parameterized nor technology scalable. In this paper, we propose more accurate parameterized power modeling techniques reflecting the actual technology parameters as well as input switching-events for memory and execution units. Compared to HSPICE, the proposed techniques show 93% and 91% accuracies for those blocks, but with a much faster simulation time. We also propose a more realistic power modeling technique for external I/O. In general, our approach includes more detailed microarchitectural and circuit modeling than has been the case in earlier simulators, without incurring a significant simulation time overhead--it can be as small as a few percent.
The Utility of File Names (2003)

For typical workloads and file naming conventions, the size, lifespan, read/write ratio, and access pattern of nearly all files in a file system are accurately predicted by the name given to the file when it is created. We discuss some name-related properties observed in three contemporary NFS workloads, and present a method for automatically creating name-based models to predict interesting file properties of new files, and analyze the accuracy of these models for our workloads. Finally, we show how these predictions can be used as hints to optimize the strategies used by the file system to manage new files when they are created. 1
Stem Cell Factor Enhances Interleukin-2–Mediated Expansion of Murine Natural Killer Cells In Vivo (1997)

The administration of low dose interleukin-2 (IL-2) results in a selective expansion of natural killer (NK) cells in vivo, and promotes the differentiation of NK cells from hematopoietic precursor cells in vitro. We have previously shown that stem cell factor (SCF ), the ligand to the c-kit tyrosine kinase receptor, enhances IL-2-induced NK cell proliferation and differentiation in vitro. Here, we investigated the effects of SCF plus IL-2 delivered to mice in vivo. Eight-week-old C57BL/6 mice were treated with a continuous subcutaneous infusion of IL-2 (1 x 10(4) IU/d) plus a daily intraperitoneal dose of SCF (100 microg/kg/d), IL-2 alone, SCF alone, or vehicle alone for 8 weeks. The in vivo serum concentration of IL-2 ranged between 352 +/- 12.0 pg/mL and 606 +/- 9.0 pg/mL, achieving selective saturation of the high affinity IL-2 receptor, while the peak SCF serum concentration was 296 +/- 13.09 ng/mL. Alone, the daily administration of SCF had no effect on the expansion of NK cells. The continuous infusion of IL-2 alone did result in a significant expansion of NK1.1+CD3- cells compared to mice treated with placebo or SCF. However, mice treated with both SCF and IL-2 showed an increase in the absolute number of NK cells that was more than twofold that seen with IL-2 alone, in the spleen (P </= .005), bone marrow (P </= .025), and blood (P < .05). NK cytotoxic activity against YAC-1 target cells was significantly higher for mice treated with SCF plus IL-2, compared to mice treated with IL-2 alone (P </= .0005). Interferon-gamma (IFN-gamma) production in cytokine-activated splenocytes was also greater for the SCF plus IL-2 group, over IL-2 treatment alone (P </= .01). The effect of SCF plus IL-2 on NK cell expansion was likely mediated via NK cell precursors, rather than mature NK cells. In summary, we provide the first evidence that SCF can significantly enhance expansion of functional NK cells induced by the prolonged administration of low dose IL-2 in vivo. Since the NK cell is a cytotoxic innate immune effector and a potent source of IFN-gamma, this therapeutic strategy for NK cell expansion may serve to further enhance innate immune surveillance against malignant transformation and infection in the setting of cancer and/or immunodeficiency.
Point Cloud Audio Processing (2021)

Most audio processing pipelines involve transformations that act on fixed-dimensional input representations of audio. For example, when using the Short Time Fourier Transform (STFT) the DFT size specifies a fixed dimension for the input representation. As a consequence, most audio machine learning models are designed to process fixed-size vector inputs which often prohibits the repurposing of learned models on audio with different sampling rates or alternative representations. We note, however, that the intrinsic spectral information in the audio signal is invariant to the choice of the input representation or the sampling rate. Motivated by this, we introduce a novel way of processing audio signals by treating them as a collection of points in feature space, and we use point cloud machine learning models that give us invariance to the choice of representation parameters, such as DFT size or the sampling rate. Additionally, we observe that these methods result in smaller models, and allow us to significantly subsample the input representation with minimal effects to a trained model performance.
An integrated system for automatic customer satisfaction analysis in the services industry (2008)

Text classification has matured well as a research discipline over the years. At the same time, business intelligence over databases has long been a source of insights for enterprises. With the growing importance of the services industry, customer relationship management and contact center operations have become very important. Specifically, the voice of the customer and customer satisfaction (C-Sat) have emerged as invaluable sources of insights about how an enterprise's products and services are percieved by customers.
Effects of annealing in air on microstructure and hardness of hydroxyapatite ceramics (2021)

Abstract In this study, microstructural variation of hydroxyapatite (HAp) ceramics upon thermal treatment in air at different temperatures was investigated by x-ray diffraction patterns, Raman and x-ray photoelectron spectroscopies. The results revealed a significant dependence of the microstructure of nonstoichiometric HAp on temperature, because of the competition between hydroxylation and different kinds of dehydroxylation at different temperatures, and a gradual increase in material hardness with annealing temperature because of structural reconstruction. In summary, a suitable thermal treatment can effectively tailor microstructure and defect contents, as well as chemical composition and mechanical hardness of HAp ceramics.
Detection of Small Changes in a Hip Prosthesis using the E-Pulse Technique (2006)

A subsurface target identification scheme based on the E-pulse technique is proposed and investigated. The target inside a homogenous medium is approximated using Baum's transform. An E-pulse is constructed with the transformed complex natural resonances (CNRs) and convolved with the target returns from subsurface targets. Numerical examples of a hip prosthesis implanted within a homogenous half space shows that the proposed technique is capable of differentiating small physical changes between two hip prosthesis models at least under a homogeneous half-space condition. The proposed method can also be applied to other subsurface target detection problems such as UXO recognition, and for a dielectric target, the problem of recognition of malignant lumps within human breast tissue
Effect of High Temperature Ageing on Active and Passive Power Devices (2010)

International audience
Point Defect Concentrations in Metastable Fe-C Alloys (2006)

Point defect species and concentrations in metastable Fe-C alloys are determined using density functional theory and a constrained free-energy functional. Carbon interstitials dominate unless iron vacancies are in significant excess, whereas excess carbon causes greatly enhanced vacancy concentration. Our predictions are amenable to experimental verification; they provide a baseline for rationalizing complex microstructures known in hardened and tempered steels, and by extension other technological materials created by or subjected to extreme environments.
Sliding wear performance of metallic laser coatings against composite PTFE seals (2018)

Abstract Laser coatings are frequently used in applications where they slide against various elastomeric and polymeric seals or guide bands in different environments. Examples of such applications include hydraulics, maritime propulsion systems and components in pulp &amp; paper industry. In this study highly corrosion resistant Inconel 625 (DIN Mat. No. 2.4856) and Thermanit 2509 super duplex stainless steel (∼1.4501) coatings manufactured by novel coaxial hot‐wire laser cladding technique are tested in dry conditions at room temperature against various composite polytetrafluoroethylene (PTFE) seals. Despite only small difference in coating surface hardness, ∼1.4501 and 2.4856 show significant differences in wear and friction performance against various seals. For instance, ∼1.4501 is superior to 2.4856 against glass fiber and MoS 2 reinforced PTFE in terms of wear resistance and friction characteristics, whereas 2.4856 performs better against bronze reinforced PTFE seal. The reference Stellite laser coating, which is the hardest counter surface in this study, exhibits the best wear behavior against all the seal materials tested. The differences in wear performances are explained by cohesive and adhesive wear mechanisms.
Accessibility of cooling centers to heat-vulnerable populations in New York State (2019)

In urban areas many residents were not within walking distance of a cooling center, but most, and nearly all in the most heat-vulnerable areas, were within walking distance of public transportation to a cooling center. In rural locations distances were longer, and accessibility is a greater issue. Cooling centers can be a valuable resource for general and heat-vulnerable populations during an extreme heat event. When planning and implementing cooling centers, it is therefore important to improve accessibility and address other barriers that can hamper their utilization.
Robotic Self-Repair in a Semi-Structured Environment (2004)

The gaseous or particulate forms of divalent mercury (Hg<sup>II</sup>) significantly impact the spatial distribution of atmospheric mercury concentration and deposition flux (FLX). In the new nested-grid GEOS-Chem model, we try to modify the Hg<sup>II</sup> gas-particle partitioning relationship with synchronous and hourly observations at four sites in China. Observations of gaseous oxidized Hg (GOM), particulate-bound Hg (PBM), and PM<sub>2.5</sub> were used to derive an empirical gas-particle partitioning coefficient as a function of temperature (T) and organic aerosol (OA) concentrations under different relative humidity (RH). Results showed that with increasing RH, the dominant process of Hg<sup>II</sup> gas-particle partitioning changed from physical adsorption to chemical desorption. And the dominant factor of Hg<sup>II</sup> gas-particle partitioning changed from T to OA concentrations. We thus improved the simulated OA concentration field by introducing intermediate-volatility and semi-volatile organic compounds (I/SVOCs) emission inventory into the model framework and refining the volatile distributions of I/SVOCs according to new filed tests in the recent literatures. Finally, normalized mean biases (NMBs) of monthly gaseous element mercury (GEM), GOM, PBM, WFLX were reduced from -33%-29%, 95%-300%, 64%-261%, 117%-122% to -13%-0%, -20%-80%, -31%-50%, -17%-23%. The improved model explains 69%-98% of the observed atmospheric Hg decrease during 2013-2020 and can serve as a useful tool to evaluate the effectiveness of the Minamata Convention on Mercury.
Metabolic engineering strategies for sesquiterpene production in microorganism (2021)

Sesquiterpenes are a large variety of terpene natural products, widely existing in plants, fungi, marine organisms, insects, and microbes. Value-added sesquiterpenes are extensively used in industries such as: food, drugs, fragrances, and fuels. With an increase in market demands and the price of sesquiterpenes, the biosynthesis of sesquiterpenes by microbial fermentation methods from renewable feedstocks is acquiring increasing attention. Synthetic biology provides robust tools of sesquiterpene production in microorganisms. This review presents a summary of metabolic engineering strategies on the hosts and pathway engineering for sesquiterpene production. Advances in synthetic biology provide new strategies on the creation of desired hosts for sesquiterpene production. Especially, metabolic engineering strategies for the production of sesquiterpenes such as: amorphadiene, farnesene, bisabolene, and caryophyllene are emphasized in: <i>Escherichia coli</i>, <i>Saccharomyces cerevisiae</i>, and other microorganisms. Challenges and future perspectives of the bioprocess for translating sesquiterpene production into practical industrial work are also discussed.
Effect of a Water Molecule on the Sugar Puckering of Uridine, 2‘-Deoxyuridine, and 2‘-<i>O</i>-Methyl Uridine Inserted in Duplexes (2008)

We used high-level quantum mechanical calculations to determine the pucker (north type or south type) of various compounds: uridine, 2'-deoxyuridine, and 2'-O-methyl uridine. Although the dihedrals of the backbone are set close to their experimental values in double-stranded nucleic acids, calculations using density functional theory show that, in vacuo or in a continuum mimicking the dielectric properties of water, the south puckering conformations of uridine is favored. This contrasts with experimental data: most ribonucleosides inserted into a duplex have the north puckering. We show here that the north puckering is favored when an explicit water molecule is introduced into the calculation. The orientations of the 2' group and of the water molecule have implications for the prevalence of the north puckering. We studied several orientations of the water molecule binding uracil O2 and the 2' group and estimated the energy barriers in the path between the north-to-south conformations. The north puckering is more favored in 2'-OH than in 2'-OCH3 compounds in the presence of the explicit water molecule.
Transjugular diagnostics in fulminant hepatitis including measurements of hepato-central venous biomarker gradients (2018)

Fulminant hepatitis (FH) and acute liver failure (ALF) are the clinical conditions representative of severe liver injury and associated with a significant risk of death. As high urgency liver transplantation may be required, early outcome prediction is essential in these patients. Prognosis scores like the model for end-stage liver disease and the King's College criteria are helpful, but further possibilities to increase accuracy would be of great value.
Mechanism‐Guided Design of Highly Efficient Protein Secretion and Lipid Conversion for Biomanufacturing and Biorefining (2019)

Bacterial protein secretion represents a significant challenge in biotechnology, which is essential for the cost-effective production of therapeutics, enzymes, and other functional proteins. Here, it is demonstrated that proteomics-guided engineering of transcription, translation, secretion, and folding of ligninolytic laccase balances the process, minimizes the toxicity, and enables efficient heterologous secretion with a total protein yield of 13.7 g L<sup>-1</sup>. The secretory laccase complements the biochemical limits on lignin depolymerization well in <i>Rhodococcus opacus</i> PD630. Further proteomics analysis reveals the mechanisms for the oleaginous phenotype of <i>R. opacus</i> PD630, where a distinct multiunit fatty acid synthase I drives the carbon partition to storage lipid. The discovery guides the design of efficient lipid conversion from lignin and carbohydrate. The proteomics-guided integration of laccase-secretion and lipid production modules enables a high titer in converting lignin-enriched biorefinery waste to lipid. The fundamental mechanisms, engineering components, and design principle can empower transformative platforms for biomanufacturing and biorefining.
Reperfusion Half-Life (2008)

The probability of reperfusion can be well described by the reperfusion half-life. Determination of the fast component reperfusion half-life may be an approach to compare the relative potency of different thrombolytic agents.
Routing in a Multi-provider Internet (1995)

This document was prepared by the author on behalf of the Internet Architecture Board (IAB). It is offered by the IAB to stimulate discussion.
Supplementary Materials from A Multicellular Basis for the Origination of Blast Crisis in Chronic Myeloid Leukemia (2023)

Supplementary Materials from A Multicellular Basis for the Origination of Blast Crisis in Chronic Myeloid Leukemia
60 GHz Transceiver Building Blocks and Measurement (2008)

The increasing demand of frequency bandwidth for broadband wireless applications results in surveys to new frequency bands, suitable for high data-rate applications. The 60 GHz band is one of the candidates for this type of applications. Due to the high operating frequency the 60 GHz topic is challenging for IC design and measurement. Integration of building blocks is important to minimise high frequency interconnects, which are uncertain design factors. Building blocks for a 60 GHz transceiver MMIC and antenna, designed and measured at TNO, are presented in this paper.
Variability in TCP round-trip times (2003)

We measured and analyzed the variability in round trip times (RTTs) within TCP connections using passive measurement techniques. We collected eight hours of bidirectional traces containing over 22 million TCP connections between end-points at a large university campus and almost $1$ million remote locations. Of these, we used over 1 million TCP connections that yield 10 or more valid RTT samples, to examine RTT variability within a TCP connection. Our results indicate that contrary to observations in several previous studies, RTT values within a connection vary widely. Our results have implications for designing better simulation models, and understanding how round trip times affect the dynamic behavior and throughput of TCP connections.
Oxygen binding to iron porphyrins (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTOxygen binding to iron porphyrinsJames P. Collman, John I. Brauman, and Kenneth S. SuslickCite this: J. Am. Chem. Soc. 1975, 97, 24, 7185–7186Publication Date (Print):November 1, 1975Publication History Published online1 May 2002Published inissue 1 November 1975https://pubs.acs.org/doi/10.1021/ja00857a050https://doi.org/10.1021/ja00857a050research-articleACS PublicationsRequest reuse permissionsArticle Views532Altmetric-Citations52LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
[Alcohol septal ablation for obstructive hypertrophic cardiomopathy]. (2019)

Alcohol septal ablation has become an attractive alternative to surgical myomectomy in symptomatic patients with obstructive hypertrophic cardiomyopathy. Its purpose is to achieve a therapeutic infarction in the sub-aortic territory responsible of the obstruction. It is indicated in symptomatic patients resistant to optimal medical treatment and having a left intraventricular gradient equal or higher than 50 mmHg, spontaneous or with exercise. The selection of candidates must be rigorous and the procedure must be performed in an experienced center, associating interventionalists and echocardiographists. Alcohol septal ablation is preferred in cases of favourable coronary anatomy, sub-aortic obstruction and absence of associated mitral valve defect. The septal alcohol technique is fast, effective and safe. The per-procedural contrast echocardiography helps identifying whether the myocardial segment is vascularized by the septal branch to be occluded. The benefits of alcohol septal ablation are comparable to those seen with surgical myectomy in terms of functional class, exercise capacity, and gradient regression. The morbidity and mortality observed in the short and mid terms are globally equivalent to that of the surgical intervention. The major complication is dominated by the occurrence of complete atrioventricular block requiring the implantation of a definitive pacemaker, a complication in sharp decline since the contrast ultrasound-guided technique has become widespread.
Asymmetric Fabry-Perot cavity based perfect absorber for infrared spectroscopic devices (2018)

Artificial subwavelength structures such as plasmonic perfect absorbers, metallic gratings and photonic crystals have been proposed to tailor the spectral absorption for spectroscopic devices.
The CroRS Two-Component Regulatory System Is Requiredfor Intrinsic β-Lactam Resistance in <i>Enterococcusfaecalis</i> (2003)

Enterococcus faecalis produces a specific penicillin-binding protein (PBP5) that mediates high-level resistance to the cephalosporin class of beta-lactam antibiotics. Deletion of a locus encoding a previously uncharacterized two-component regulatory system of E. faecalis (croRS) led to a 4,000-fold reduction in the MIC of the expanded-spectrum cephalosporin ceftriaxone. The cytoplasmic domain of the sensor kinase (CroS) was purified and shown to catalyze ATP-dependent autophosphorylation followed by transfer of the phosphate to the mated response regulator (CroR). The croR and croS genes were cotranscribed from a promoter (croRp) located in the rrnC-croR intergenic region. A putative seryl-tRNA synthetase gene (serS) located immediately downstream from croS did not appear to be a target of CroRS regulation or to play a role in ceftriaxone resistance. A plasmid-borne croRp-lacZ fusion was trans-activated by the CroRS system in response to the presence of ceftriaxone in the culture medium. The fusion was also induced by representatives of other classes of beta-lactam antibiotics and by inhibitors of early and late steps of peptidoglycan synthesis. The croRS null mutant produced PBP5, and expression of an additional copy of pbp5 under the control of a heterologous promoter did not restore ceftriaxone resistance. Deletion of croRS was not associated with any defect in the synthesis of the nucleotide precursor UDP-MurNAc-pentapeptide or of the D-Ala(4)-->L-Ala-L-Ala-Lys(3) peptidoglycan cross-bridge. Thus, the croRS mutant was susceptible to ceftriaxone despite the production of PBP5 and the synthesis of wild-type peptidoglycan precursors. These observations constitute the first description of regulatory genes essential for PBP5-mediated beta-lactam resistance in enterococci.