gebhart/patrepeval huggingface dataset:
Achieving delay rate-function optimality in OFDM downlink with time-correlated channels (2016)

There have been recent attempts to develop scheduling schemes for downlink transmission in a single cell of a multi-channel (e.g., OFDM-based) cellular network. These works have been quite promising in that they have developed low-complexity index scheduling policies that are delay-optimal (in a large deviation rate-function sense). However, these policies require that the channel is ON or OFF in each time-slot with a fixed probability (i.e., there is no memory in the system), while the reality is that due to channel fading and doppler shift, channels are often time-correlated in these cellular systems. Thus, an important open question is whether one can find simple index scheduling policies that are delay-optimal even when the channels are time-correlated. In this paper, we attempt to answer this question for time-correlated ON/OFF channels. In particular, we show that the class of oldest packets first (OPF) policies that give a higher priority to packets with a large delay is delay rate-function optimal under two conditions: 1) The channel is non-negatively correlated, and 2) The distribution of the OFF period is geometric. We use simulations to further elucidate the theoretical results.
THE INHERITANCE OF OZONE INSENSITIVITY IN SELECTED <i>Phaseolus vulgaris</i> L. POPULATIONS (1982)

Broad sense heritability estimates (H) for ozone (O 3 ) insensitivity in four P. vulgaris F 2 populations were high (0.66–0.88) under artifical fumigation conditions. In the F 3 , under field conditions, broad sense H in two populations had declined to 0.16 and 0.21, probably as a result of the interaction of maturity and injury. The results suggest that selection for O 3 insensitivity in early generations should be conducted under controlled fumigation conditions followed by field evaluations as lines approach homozygosity.
Desensitization and sensitization of cells to fluoropyrimidines with different antisenses directed against thymidylate synthase messenger RNA. (1998)

Previous studies have shown that the cytotoxicity of fluoropyrimidines is mediated, in large part, by inhibition of the enzyme thymidylate synthase (TS). The aim of this study was to determine whether the chemosensitivity of human cancer cells to fluoropyrimidines could be increased by decreasing TS expression with antisense oligodeoxyribonucleotides (ODNs). ODNs (18-mers) targeted at the AUG translational initiation site of TS mRNA inhibited translation in a sequence- and dose-dependent manner in a rabbit reticulocyte lysate in vitro translation system. Treatment of human colon cancer HT-29 cells with antisense ODNs decreased TS catalytic activity in the cells in a dose-dependent manner over a short period, but the longer-term effect of the TS antisense ODN treatment was actually to increase the amount of TS in the cells and to decrease their sensitivity to 5-fluoro-2'-deoxyuridine (FdUrd). However, when human nasopharyngeal cancer KB31 cells were transfected with a plasmid (pHaMAGRP) construct containing the TS antisense fragment (+ 1 to + 422) under the control of a glucose-regulated promoter, the expression of both TS protein and TS catalytic activity was decreased by nearly 30% (P = 0.014), and sensitivity of these cells to FdUrd was enhanced by approximately 8-fold (P = 0.021). No changes in the levels of expression of TS protein or FdUrd-associated cytotoxicity were observed in control, vector-transfected cells. No change was observed in the sensitivity of transfected cells toward either cisplatin or Adriamycin. These results show that the level of expression of TS in human malignant cells can be down-regulated with antisense TS RNA, and their sensitivity to fluoropyrimidines can, thereby, be increased.
P3‐287: Composite cognitive endpoints with improved power to detect presymptomatic Alzheimer's disease treatment effects: Findings in the Colombian kindred with the E280A Presenilin 1 mutation and the Alzheimer's Prevention Initiative (2011)

We have proposed an Alzheimer's Prevention Initiative (API) to relate a presymptomatic Alzheimer's disease (AD) treatment's biomarker effects to clinical outcome in cognitively normal people at the highest imminent risk to develop AD, including the world's largest kindred of early-onset AD (EOAD) causing mutation carriers (mean age at clinical onset=45), from Antioquia, Colombia. Here, we used longitudinal data from cognitively normal E280A Presenilin 1 (PS1) mutation carriers and non-carriers over age 35 to 1) characterize the combination of cognitive tests most sensitive to cognitive decline, 2) estimate the number of mutation carriers needed in randomized clinical trial (RCTs) to detect AD-slowing treatment effect on the composite cognitive endpoint, and 3) estimate the treatment effect that could be detected in 75 PS1 mutation carriers with 80% power and p=0.05. A battery of 19 cognitive tests, acquired every 2-5 years between 1995 and 2010 by the Neuroscience group at the University of Antioquia, was used to calculate the mean-to-standard-deviation ratios (MSDR) for each combination of one to six measurements. Measurements were adjusted for aging/practice effects using data from no carriers. The best combination was used to estimate statistical power in 24-60 month presymptomatic AD RCTs. After practice/aging correction, the optimal combination to predict cognitive decline included CERAD word list delayed recall, category verbal fluency, MMSE Orientation and Time, Constructional Praxis and Ravens progressive matrices. (A similar pattern was observed in cognitively normal older APOE4 carriers [Langbaum et al, ICAD abstract 2011]). We estimate the need for 215/79 PS1 mutation carriers per group over the age of 35, respectively, to detect a 25% treatment effect in a 24/60-month RCT. We estimate that 75 carriers per group would permit us to detect 43/26% treatment effects, respectively in a 24/60-month RCT. We have identified a combination of cognitive tests to evaluate presymptomatic AD treatments in cognitive normal people at highest imminent risk for EOAD. We have found a similar combination in those at highest risk for late-onset AD. We will continue to develop this approach in preparation for the presymptomatic AD/surrogate marker development trials proposed in the API.
Crossed-beam study of the reaction H3O+(D2O,H2O)D2HO+ (1980)

ADVERTISEMENT RETURN TO ISSUEArticleNEXTCrossed-beam study of the reaction H3O+(D2O,H2O)D2HO+P. W. Ryan, C. R. Blakley, M. L. Vestal, and J. H. FutrellCite this: J. Phys. Chem. 1980, 84, 6, 561–567Publication Date (Print):March 1, 1980Publication History Published online1 May 2002Published inissue 1 March 1980https://pubs.acs.org/doi/10.1021/j100443a001https://doi.org/10.1021/j100443a001research-articleACS PublicationsRequest reuse permissionsArticle Views64Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Mixed Acetate‐Glycerol Biosynthesis and Formation of Benzoate Directly from Shikimate in<i> Streptomyces</i> sp. (2004)

Abstract Biosynthetic studies of γ‐butyrolactones and 3‐furanylcarbonyl α‐ L ‐rhamnopyranosides reveal a new mixed biosynthetic pathway which provides different types of secondary metabolites. The new γ‐butyrolactone 1 is produced by Streptomyces sp. (strain GT 61150) together with (propenyl‐3‐furanyl)carbonyl α‐ L ‐rhamnopyranoside ( 2 ). Their structures were elucidated by chemical and spectroscopic methods. The biosynthesis of 1 and 2 was established by feeding 13 C‐labelled acetate and glycerol to Streptomyces sp. and resulted in a complete labelling pattern of 1 and 2 . Benzoyl α‐ L ‐rhamnopyranoside ( 3 ) is a rare compound of the rhamnoside family and is produced by Streptomyces griseoviridis (strain Tü 3634). [1,7‐ 13 C 2 ]Shikimic acid was fed to prove the hypothesis that the benzoyl unit is derived directly from shikimate and not from the plant‐like pathway with phenylalanine as an intermediate. The results exemplify a novel bacterial benzoate biosynthesis. (© Wiley‐VCH Verlag GmbH &amp; Co. KGaA, 69451 Weinheim, Germany, 2004)
Design, fabrication, and evaluation of high frequency, single-element transducers incorporating different materials (2002)

The performance of high frequency, single-element transducers depends greatly on the mechanical and electrical properties of the piezoelectric materials used. This study compares the design and performance of transducers incorporating different materials. The materials investigated include 1-3 lead zirconate titanate (PZT) fiber composite, lead titanate (PbTiO3) ceramic, poly(vinylidene fluoride) (PVDF) film, and lithium niobate (LiNbO3) single crystal. All transducers were constructed with a 3-mm aperture size and an f-number between 2 and 3. Backing and matching materials were selected based on design goals and fabrication limitations. A simplified coaxial cable tuning method was employed to match the transducer impedance to 50 ohms for the PZT fiber composite and PbTiO3 ceramic transducers. Transducers were tested for two-way loss and -6 dB bandwidth using the pulse/echo response from a flat quartz target. Two-way loss varied from 21 to 46 dB, and bandwidths measured were in the range from 47 to 118%. In vitro ultrasonic backscatter microscope (UBM) images of an excised human eye were obtained for each device and used to compare imaging performance. Both press-focusing and application of a lens proved to be useful beam focusing methods for high frequency. Under equal gain schemes, the LiNbO3 and PbTiO3 transducers provided better image contrast than the other materials.
Optimal timing and interval of imaging for metastatic breast cancer. (2022)

1106 Background: Breast cancer is a family of diseases with varying disease trajectories based on intrinsic biology of the tumor. The time of progression varies across &amp; within subtypes, and with increasing rates of drug resistance depending on prior therapeutic exposure. There is no strong consensus about optimal surveillance and routine imaging in patients with metastatic breast cancer (mBC), but many oncologists report that monitoring strategies are based on strategies used in clinical trials. Methods: We reviewed 17 prior Phase III studies that led to FDA approval in mBC. We reviewed 8 studies for ER+ mBC, 5 studies for HER2+ mBC, 2 studies for triple negative (TNBC) mBC, and 2 studies for BRCA+ mBC. We calculated rates of progression or death (POD) per month for the first year on therapy using data from survival analysis tables and compared them across the different types and lines of therapy. Results: Risk of progression in mBC varies based on receptor status and line of therapy (Table). There was a significant difference in POD rates between ER+ therapies compared with all other disease types (HER2+, TNBC, BRCA) (p = 0.012). Patients with TNBC or receiving PARP inhibitors or later line HER2 therapies had higher POD rates than those with ER+ breast cancer or receiving first line HER2 therapy (6.9% vs 4.1% per month; p = 0.0004). No significant difference was seen in the monitoring frequency between ER+ and HER2+ disease (p = 0.39). Conclusions: These data suggest that shorter interval imaging should be performed for patients with TNBC or receiving PARP inhibitors or later line HER2 therapies. Surveillance imaging for patients with mBC should be based on disease biology, number of prior regimens, time since initiation of therapy, and regimen efficacy. Current imaging recommendations are not data-based and do not adjust for new agents that have been approved. Oncologists should integrate these into individualized estimates to determine optimum frequency of imaging in clinical practice and research. [Table: see text]
Meningococcal PilV Potentiates Neisseria meningitidis Type IV Pilus-Mediated Internalization into Human Endothelial and Epithelial Cells (2012)

The type IV pilus of Neisseria meningitidis is the major factor for meningococcal adhesion to host cells. In this study, we showed that a mutant of N. meningitidis pilV, a minor pilin protein, internalized less efficiently to human endothelial and epithelial cells than the wild-type strain. Matrix-assisted laser desorption ionization-time of flight mass spectrometry and electrospray ionization tandem mass spectrometry analyses showed that PilE, the major subunit of pili, was less glycosylated at its serine 62 residue (Ser62) in the ΔpilV mutant than in the pilV(+) strain, whereas phosphoglycerol at PilE Ser93 and phosphocholine at PilE Ser67 were not changed. Introduction of the pglL mutation, which results in complete loss of O-linked glycosylation from Ser62, slightly reduced N. meningitidis internalization into human brain microvascular endothelial cells, whereas the addition of the ΔpilV mutation greatly reduced N. meningitidis internalization. The accumulation of ezrin, which is part of the cytoskeleton ERM family, was observed with pilV(+), ΔpglL, and pilE(S62A) strains but not with the ΔpilV mutant. These results suggested that whereas N. meningitidis pilin originally had an adhesive activity that was less affected by minor pilin proteins, the invasive function evolved with incorporation of the PilV protein into the pili to promote the N. meningitidis internalization into human cells.
Gecko-Inspired Biocidal Organic Nanocrystals Initiated from a Pencil-Drawn Graphite Template (2018)

The biocidal properties of gecko skin and cicada wings have inspired the synthesis of synthetic surfaces decorated with high aspect ratio nanostructures that inactivate microorganisms. Here, we investigate the bactericidal activity of oriented zinc phthalocyanine (ZnPc) nanopillars grown using a simple pencil-drawn graphite templating technique. By varying the evaporation time, nanopillars initiated from graphite that was scribbled using a pencil onto silicon substrates were optimized to yield a high inactivation of the Gram-negative bacteria, Escherichia coli. We next adapted the procedure so that analogous nanopillars could be grown from pencil-drawn graphite scribbled onto stainless steel, flexible polyimide foil, and glass substrates. Time-dependent bacterial cytotoxicity studies indicate that the oriented nanopillars grown on all four substrates inactivated up to 97% of the E. coli quickly, in 15 min or less. These results suggest that organic nanostructures, which can be easily grown on a broad range of substrates hold potential as a new class of biocidal surfaces that kill microbes quickly and potentially, without spreading antibiotic-resistance genes.
Connecting families (2010)

tutorial Share on Connecting families: new technologies, family communication, and the impact on domestic space Authors: Carman Neustaedter Simon Fraser University, Surrey, BC, Canada Simon Fraser University, Surrey, BC, CanadaView Profile , Tejinder K. Judge Virginia Tech, Blacksburg, VA, USA Virginia Tech, Blacksburg, VA, USAView Profile , Steve Harrison Virginia Tech, Blacksburg, VA, USA Virginia Tech, Blacksburg, VA, USAView Profile , Abigail Sellen Microsoft Research Cambridge, Cambridge, United Kingdom Microsoft Research Cambridge, Cambridge, United KingdomView Profile , Xiang Cao Microsoft Research Cambridge, Cambridge, United Kingdom Microsoft Research Cambridge, Cambridge, United KingdomView Profile , David Kirk University of Nottingham University of NottinghamView Profile , Joseph Kaye Nokia Research Nokia ResearchView Profile Authors Info & Claims GROUP '10: Proceedings of the 16th ACM international conference on Supporting group workNovember 2010 Pages 363–366https://doi.org/10.1145/1880071.1880152Online:07 November 2010Publication History 8citation633DownloadsMetricsTotal Citations8Total Downloads633Last 12 Months38Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Pharmacological Interaction between Diets and Commensal Bacteria for the Creation of Lipid Environment in the Control of Health and Diseases (2021)

The intestine is exposed to a variety of exogenous materials that are harmful, harmless, or useful, such as pathogenic viruses and bacteria, intestinal bacteria, or food components. As such, the intestinal immune system is important for the regulation of immunological homeostasis and biological defense. Accumulating evidence indicates that gut environmental factors, such as dietary components and intestinal bacteria are critical for controlling intestinal immunity, and thereby, health and disease. Among the important dietary components are fatty acids, which are metabolized to lipid mediators that act as signaling molecules and regulate immune responses. In previous work, we identified lipid mediators derived from ω3 fatty acids, such as 17,18-epoxyeicosatetraenoic acid, 15-hydroxyeicosapentaenoic acid, and 14-hydroxydocosapentaenoic acid, which show potent anti-allergic and anti-inflammatory activities. In addition, we revealed that lipid mediators play key roles in the enhancement of intestinal Immunoglobulin A responses, which provide the first line of defense against viral and bacterial infectious diseases. Here, we review the anti-allergic, anti-inflammatory, and host-protective effects of lipid mediators mainly derived from dietary lipids.
Generating Procedural 3D materials from Images using Neural Networks (2022)

Generating photo-realistic 3D materials from images is a challenging task in 3D modeling. In the absence of suitable 3D material assets from online material collections, texture artists have to resort to designing their own materials from reference images; a time-consuming process requiring significant expertise. Recent works on material estimation are limited by the number and resolution of 3D materials they can generate. Our work addresses these limitations through a novel framework and dataset for generating procedural materials from images. We introduce a set of 314 procedural material models each with parameters that can be varied to generate an infinite number of materials. We leverage a neural network architecture to predict materials as variations of a suitable model in our model library. Our framework is able to produce high-resolution photo-realistic 3D materials from input images. Our neural network is able to handle 314 procedural material models, a significant improvement of previous works training 17 neural networks to predict parameters of 17 procedural models. We evaluate our framework against a retrieval baseline, and show that our approach yields significant improvement on parameter estimation, and visual appearance.
A hybrid formalism combining fluctuating hydrodynamics and generalized Langevin dynamics for the simulation of nanoparticle thermal motion in an incompressible fluid medium (2012)

A novel hybrid scheme based on Markovian fluctuating hydrodynamics of the fluid and a non-Markovian Langevin dynamics with the Ornstein-Uhlenbeck noise perturbing the translational and rotational equations of motion of the nanoparticle is employed to study the thermal motion of a nanoparticle in an incompressible Newtonian fluid medium. A direct numerical simulation adopting an arbitrary Lagrangian-Eulerian (ALE) based finite element method (FEM) is employed in simulating the thermal motion of a particle suspended in the fluid confined in a cylindrical vessel. The results for thermal equilibrium between the particle and the fluid are validated by comparing the numerically predicted temperature of the nanoparticle with that obtained from the equipartition theorem. The nature of the hydrodynamic interactions is verified by comparing the velocity autocorrelation function (VACF) and mean squared displacement (MSD) with well-known analytical results. For nanoparticle motion in an incompressible fluid, the fluctuating hydrodynamics approach resolves the hydrodynamics correctly but does not impose the correct equipartition of energy based on the nanoparticle mass because of the added mass of the displaced fluid. In contrast, the Langevin approach with an appropriate memory is able to show the correct equipartition of energy, but not the correct short- and long-time hydrodynamic correlations. Using our hybrid approach presented here, we show for the first time, that we can simultaneously satisfy the equipartition theorem and the (short- and long-time) hydrodynamic correlations. In effect, this results in a thermostat that also simultaneously preserves the true hydrodynamic correlations. The significance of this result is that our new algorithm provides a robust computational approach to explore nanoparticle motion in arbitrary geometries and flow fields, while simultaneously enabling us to study carrier adhesion mediated by biological reactions (receptor-ligand interactions) at the vessel wall at a specified finite temperature.
A general synthetic methodology to access magnesium aluminate electrolyte systems for Mg batteries (2019)

A general method for the preparation of Mg aluminate electrolyte systems is presented along with their electrochemical behaviour.
Flips in Two-dimensional Hypertriangulations (2022)

We study flips in hypertriangulations of planar points sets. Here a level-$k$ hypertriangulation of $n$ points in the planes is a subdivision induced by the projection of a $k$-hypersimplex, which is the convex hull of the barycenters of the $(k-1)$-dimensional faces of the standard $(n-1)$-simplex. In particular, we introduce four types of flips and prove that the level-2 hypertriangulations are connected by these flips.
Conceptual Clustering Algorithms Using Regression Analysis (2001)

This paper presents conceptual clustering algorithms using regression analysis. The basic idea is that given data can be classified to the class “existing” and so conceptual clustering(unsupervised learning) is transformed to classification (supervised learning). The algorithms consist of transforming given data to the data with a class, obtaining a function({0, 1}n →[0, 1]) by regression analysis, approximating the function by a Boolean function, and generating a concept hierarchy from the Boolean function. Regression analysis includes linear regression analysis and nonlinear regression analysis by neural networks. The algorithms can perform the multiple classification and generate simple clusters. The algorithms using linear regression analysis and neural networks have been applied to real data. Results show that the algorithm using neural networks works well.
Practical aspects of an innovative solid streamer concept (2005)

A new low noise solid streamer concept has been developed in cooperation between PGS and Teledyne. The new concept is based on an acoustically transparent solid fill material called BVF. The material has been specially designed for use in marine towed streamer acquisition systems, but is very likely to be of use in many geophysical sub‐sea applications. This paper elaborates on the properties of the material, and the unique performance of the innovative solid streamer concept.