gebhart/patrepeval huggingface dataset:
A phase 2, open‐label study of single‐dose dupilumab in children aged 6 months to &lt;6 years with severe uncontrolled atopic dermatitis: pharmacokinetics, safety and efficacy (2020)

Abstract Background Dupilumab has demonstrated efficacy and acceptable safety in adults and children (aged 6–17 years) with moderate‐to‐severe atopic dermatitis (AD), but effective systemic therapy with a favorable risk–benefit profile in younger children remains a significant unmet need. Objectives To determine the pharmacokinetics, safety and efficacy of single‐dose dupilumab in children with severe AD aged ≥6 months to &lt;6 years. Methods This open‐label, multicenter, phase 2, sequential, two‐age cohort, two‐dose level study (LIBERTY AD PRE‐SCHOOL; NCT03346434) included an initial cohort of older children aged ≥2 to &lt;6 years, followed by a younger cohort aged ≥6 months to &lt;2 years. Pharmacokinetic sampling, safety monitoring and efficacy assessments were performed during the 4‐week period after a single subcutaneous injection of dupilumab, in two sequential dosing groups (3 mg/kg, then 6 mg/kg). The use of standardized, low‐to‐medium potency topical corticosteroids was allowed. Results Forty patients were enrolled (20/age cohort, 10/dose level within a cohort) between December 20, 2017 and July 22, 2019. Within each age cohort, pharmacokinetic exposures after a single injection of dupilumab increased in a greater than dose‐proportional manner. At week 3, treatment with 3 and 6 mg/kg dupilumab reduced scores of mean Eczema Area and Severity Index by −44.6% and −49.7% (older cohort) and −42.7% and −38.8% (younger cohort), and mean Peak Pruritus NRS scores by −22.9% and −44.7% (older cohort) and −11.1% and −18.2% (younger cohort), respectively. At week 4, improvements in most efficacy outcomes diminished in both age groups, particularly with the lower dose. The safety profile was comparable to that seen in adults, adolescents and children. Conclusions Single‐dose dupilumab was generally well tolerated and substantially reduced clinical signs/symptoms of AD. Slightly better responses were seen in older than younger children. The pharmacokinetics of dupilumab were non‐linear, consistent with previous studies in adults and adolescents.
Supplementary Data from Induction of Anti-Glioma Natural Killer Cell Response following Multiple Low-Dose Intracerebral CpG Therapy (2023)

&lt;p&gt;Supplementary Figure S1.&lt;/p&gt;
Short-circuiting a water-mediated enzyme reaction (1996)

visible in the 12-fold averaged structure. Due to selective binding of ADP within the dodecamer, the GS molecule deviates from exact 62 symmetry. This explains the preference of the C2 crystal form over hexagonal crystal fonns which are observed for higher and lower ADP concentrations.
Long‐chain alkane production by the yeast <i>Saccharomyces cerevisiae</i> (2014)

In the past decade industrial-scale production of renewable transportation biofuels has been developed as an alternative to fossil fuels, with ethanol as the most prominent biofuel and yeast as the production organism of choice. However, ethanol is a less efficient substitute fuel for heavy-duty and maritime transportation as well as aviation due to its low energy density. Therefore, new types of biofuels, such as alkanes, are being developed that can be used as drop-in fuels and can substitute gasoline, diesel, and kerosene. Here, we describe for the first time the heterologous biosynthesis of long-chain alkanes by the yeast Saccharomyces cerevisiae. We show that elimination of the hexadecenal dehydrogenase Hfd1 and expression of a redox system are essential for alkane biosynthesis in yeast. Deletion of HFD1 together with expression of an alkane biosynthesis pathway resulted in the production of the alkanes tridecane, pentadecane, and heptadecane. Our study provides a proof of principle for producing long-chain alkanes in the industrial workhorse S. cerevisiae, which was so far limited to bacteria. We anticipate that these findings will be a key factor for further yeast engineering to enable industrial production of alkane based drop-in biofuels, which can allow the biofuel industry to diversify beyond bioethanol.
Determination of the Absolute Chirality of Adsorbed Molecules (2004)

Intramolecular “electron lamp” throws bright shadows: Angle-scanned X-ray photoelectron diffraction (XPD) allows the absolute configuration of adsorbed molecules to be determined in a straightforward way. Owing to intramolecular scattering, the C 1s XPD pattern of tartaric acid adsorbed on Cu(110) (see picture; Cu brown, C blue, O red) has pronounced forward-focusing maxima that directly yield the absolute molecular conformation without the need for complex calculations.
Parametric excitation of a Helmholtz resonator (1998)

Parametric excitation of an oscillator results from the modulation of a parameter upon which the natural frequency of the oscillator depends. If the drive amplitude exceeds a threshold determined by dissipation, the response amplitude grows exponentially until it is saturated by a nonlinearity of the system. Hence, large amplitudes may be possible. An unsuccessful attempt to parametrically excite the fundamental mode of a Helmholtz resonator is reported. The apparatus consists of two equal-volume cavities connected by a U-shaped neck similar to a trombone slide, where the neck length is modulated at twice the Helmholtz frequency. In model systems, the effective quality factor diverges as the parametric drive amplitude approaches threshold from below. the extent to which a parametric drive amplitude is below threshold can thus be probed by performing a frequency sweep with a small-amplitude direct drive. However, the effective quality factor in our system is found to decrease as the parametric drive amplitude is increased, as a result of turbulence caused by the parametric drive. This indicates that parametric excitation by neck length modulation may not be possible. Current work on a Helmholtz resonator in which the cavity volume is modulated is also reported on. [Work sponsored by ONR.]
Cigarette Smoking Is Associated with Subclinical Parenchymal Lung Disease (2009)

Smoking may cause subclinical parenchymal lung disease detectable by spirometry and CT imaging, even among a generally healthy cohort.
Role of the stereochemistry of the hydroxyl group of cholesterol and the formation of nonbilayer structures in phosphatidylethanolamines (1989)

The phase behavior of mixtures of cholesterol or epicholesterol with phosphatidylethanolamine was studied by differential scanning calorimetry and by X-ray diffraction. Discrete domains of cholesterol are detected by X-ray diffraction in the L alpha phase of phosphatidylethanolamine from egg yolk and synthetic dielaidoylphosphatidylethanolamine beginning at mole fractions of 0.35-0.4 cholesterol. Separate domains of crystalline epicholesterol can also be detected in the L alpha phase of dielaidoylphosphatidylethanolamine by X-ray diffraction at as little as 0.16 mole fraction of epicholesterol. This is a result of poor miscibility of the epicholesterol with dielaidoylphosphatidylethanolamine. Epicholesterol does not alter the L beta----L alpha transition or bilayer spacing. Epicholesterol also has little effect on the diameter of the cylinders in the hexagonal phase. Formation of the inverted hexagonal phase is facilitated by addition of small amounts of cholesterol (mole fraction less than 0.2) in both egg phosphatidylethanolamine and dielaidoylphosphatidylethanolamine. However, at higher mole fractions of cholesterol, the stability of the liquid-crystalline phase is found to increase markedly for dielaidoylphosphatidylethanolamine but not for egg phosphatidylethanolamine, indicating the importance of the structure of the acyl chains in controlling the relative stability of the lamellar and nonlamellar phases in these systems. In contrast to cholesterol, epicholesterol markedly lowers the L alpha----HII phase transition temperature at low mole fraction of sterol. This result demonstrates the importance of the orientation and motional properties of an additive in determining the L alpha----HII transition temperature.
Sequencing computation steps in a network (1981)

It is sometimes necessary in the course of a distributed computation to arrange that a certain set of operations is carried out in the correct order and the correct number of times (typically once). If several sets of operations are performed on different machines on the network there is no obvious mechanism for enforcing such ordering constraints in a fully distributed way. This lack basically stems from the difficulty of preventing copying and repetition of messages by machines and from the impossibility of constraining externally the actions of machines in response to messages that come into their hands. This paper presents a possible method for ensuring the integrity of sequences of operations on different machines. The technique may be thought of as a means of enabling machines to ensure that requests made of them are valid and timely, not as means of centralized control of services.
Protein–Protein Interactions between Sucrose Transporters of Different Affinities Colocalized in the Same Enucleate Sieve Element (2002)

Suc represents the major transport form for carbohydrates in plants. Suc is loaded actively against a concentration gradient into sieve elements, which constitute the conduit for assimilate export out of leaves. Three members of the Suc transporter family with different properties were identified: SUT1, a high-affinity Suc proton cotransporter; SUT4, a low-affinity transporter; and SUT2, which in yeast is only weakly active and shows features similar to those of the yeast sugar sensors RGT2 and SNF3. Immunolocalization demonstrated that all three SUT proteins are localized in the same enucleate sieve element. Thus, the potential of Suc transporters to form homooligomers was tested by the yeast-based split-ubiquitin system. The results show that both SUT1 and SUT2 have the potential to form homooligomers. Moreover, all three Suc transporters have the potential to interact with each other. As controls, a potassium channel and a monosaccharide transporter, expressed in the plasma membrane, did not interact with the SUTs. The in vivo interaction between the functionally different Suc transporters indicates that the membrane proteins are capable of forming oligomeric structures that, like mammalian Glc transporter complexes, might be of functional significance for the regulation of transport.
Correction to Structure–Activity Studies of Peptides from the “Hot-Spot” Region of Human CD2 Protein: Development of Peptides for Immunomodulation (2012)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Structure–Activity Studies of Peptides from the "Hot-Spot" Region of Human CD2 Protein: Development of Peptides for ImmunomodulationJining Liu, Jinfa Ying, Vincent T. K. Chow, Victor J. Hruby, and Seetharama D. Satyanarayanajois*Cite this: J. Med. Chem. 2012, 55, 16, 7295Publication Date (Web):August 3, 2012Publication History Published online3 August 2012Published inissue 23 August 2012https://pubs.acs.org/doi/10.1021/jm3010948https://doi.org/10.1021/jm3010948correctionACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views360Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (109 KB) Get e-Alertsclose Get e-Alerts
Improvement in Solubility and Molecular Assembly of Cyclopentadithiophene-Benzothiadiazole Polymer (2015)

Using linear side chains for conjugated polymers is hindered by their limited solubility in common organic solvents, creating problems during purification and processing, whereas branched alkyl chains generally preclude interchain interdigitation because their bulkiness usually hinders interchain interactions. To compensate the adverse effects from each side chain, it is shown that replacing commonly employed 2-ethylhexyl (2EH) solubilizing groups with branched 5-ethylnonyl (5EN) chains not only improves solution processability to PCDT-BT polymer, but also induces an advantageous change in polymer self-assembly and backbone orientation in thin films that correlates with an increase in transistor performance.
A Robust Musical Audio Search Method Based On Diagonal Dynamic Programming Matching Of Self-Similarity Matrices. (2008)

[TODO] Add abstract here.
A Multi-Modal Conducting Simulator (1998)

近年, 音楽へのソフトコンピューティング応用例が増えている.柔らかい処理が音楽情報処理に適していると考えられる.本稿ではマルチモーダル指揮シミュレータ試作への応用を報告する.人の指揮を認識し実時間にオーケストラのように振る舞う.指揮動作の特徴や時間構造は前後の脈絡や人により揺らぐ.それを吸収して指揮の意図を抽出する為にHMM(隠れマルコフモデル)とファジィによる柔らかい処理を導入し, 拍認識処理を人の認識に倣って構築した.右手指揮動作を加速度センサで, 視点を視線検出器で, 呼吸を呼吸センサで検出する.狭義の動作認識にHMMを適用.楽員(オーケストラ奏者)や指揮者へのインタビューで得た知見に基づき, 曲の知識や演奏情報の活用をファジィ推論で実現した.指揮法に則った普遍性ある重要な要素, 即ち, 曲の演奏開始(出, 予備動作)や停止, 目によるアインザッツ(Einsatz, 奏者へのcue=出の指示), 拍タイミング(アゴーギク=テンポ変動を含む), 何番目の拍か, フェルマータ(任意の長さに音符や休符を延ばす), デュナーミク(音の強弱), 一部のアーティキュレーション(奏法), 呼吸法を認識する.これに基づき実時間に音楽演奏を制御する.正しい呼吸法や指揮者の重要な仕事の1つであるアインザッツに対するオーケストラの反応, 発音時間遅れや自律性もシミュレートした.自律度最大では指揮入力を無視して曲のテンポデータに基づいて演奏し, 自律度最低では指揮に密着して動作停止と同時に演奏停止し, 次の動作入力まで待ち続ける.
Supplementary Table 4 from Identification of Lethal microRNAs Specific for Head and Neck Cancer (2023)

&lt;p&gt;PDF file, 437K, Genes predicted to have potential binding sites for the six tumor-slective lethal microRNAs.&lt;/p&gt;
Prevalencia de síntomas muscoloesqueléticos en trabajadores de una unidad de medicina familiar (2019)

Introduccion: Los trastornos musculoesqueleticos (TME) son de los problemas mas
importantes de salud en el trabajo, de lesion e incapacidad ocupacional. Afectan la
calidad de vida de trabajadores y se traducen en un importante costo socioeconomico
para las empresas e instituciones de salud.
Objetivo: Determinar la prevalencia de sintomas musculoesqueleticos en trabajadores
de una unidad de medicina familiar.
Metodologia: Estudio descriptivo, prospectivo, transversal con trabajadores de la unidad
de medicina familiar 61 de Veracruz, utilizando el cuestionario nordico estandarizado
para deteccion de sintomas musculoesqueleticos (SME) en el periodo comprendido
entre agosto y octubre del ano 2018.
Physical Properties of Finola® Hemp Seeds: Clean and Containing Dockages (2018)

Abstract. Physical properties of hemp seeds (, L., cultivar Finola ® ) with 5%, 10%, and 15% foreign materials and dockages (FMD) at 9%, 12%, and 15% moisture contents (wet basis) were measured. The measured and determined physical properties include physical dimensions (length, width, thickness, kernel volume, sphericity, and average surface area), density (bulk and true density), porosity, weight of 1000 kernels, filling and empting angles of repose, and coefficients of friction on surfaces of plywood, galvanized steel, steel-troweled concrete, and wood-floated concrete. The mean value of the length, width, and thickness of the 50 kernels had a linear relationship with the increase of moisture content; however, this was not true for individual kernels. Bulk density of seeds at any FMD level decreased linearly or quadratically with the moisture content increase, while the true density had an opposite trend. Increasing FMD significantly increased the bulk density at any moisture content, and there were variations for the true density. There were gaps between the seed coat and cotyledon, and these gaps became smaller or disappeared when the seed moisture content was increased. This phenomenon resulted in the same average surface area, same volume, and exponential increase in porosity to 58.5% with the increase of moisture content. Increased FMD significantly decreased the porosity at any moisture content. Emptying angle of repose increased with the increase of moisture contents and percentage of FMD. Higher variability was observed in the filling angle of repose than in the emptying angle of repose. The coefficient of friction was the largest against wood-floated and steel-troweled concrete, followed by galvanized steel, and the smallest was against the plywood surface. Keywords: Angle of repose, Density, Foreign material and dockage (FMD), Friction against structural surface, Hemp seed, Physical dimensions.
[(C⁁N⁁N)Pt(CC)nR] (HC⁁N⁁N = 6-aryl-2,2′-bipyridine, n = 1–4, R = aryl, SiMe3) as a new class of light-emitting materials and their applications in electrophosphorescent devicesElectronic supplementary information (ESI) available: General experimental procedure, analytical and spectral characterizations, OLED fabrication and performance. See http://www.rsc.org/suppdata/cc/b1/b108793b/ (2002)

Tridentate cyclometalated platinum(II) complexes bearing sigma-alkynyl ligands exhibit tunable photoluminescence and enhanced stability during vacuum deposition; OLEDs based on these materials display orange to red electrophosphorescence with low turn-on voltages (approximately 4 V), maximum luminance approaching 10,000 cd m-2 and efficiency up to 4.2 cd A-1.
Tumor-Induced Senescent T Cells with Suppressor Function: A Potential Form of Tumor Immune Evasion (2008)

Senescent and suppressor T cells are reported to be increased in select patients with cancer and are poor prognostic indicators. Based on the association of these T cells and poor outcomes, we hypothesized that tumors induce senescence in T cells, which negatively effects antitumor immunity. In this report, we show that human T cells from healthy donors incubated with tumor for only 6 h at a low tumor to T-cell ratio undergo a senescence-like phenotype, characterized by the loss of CD27 and CD28 expression and telomere shortening. Tumor-induced senescence of T cells is induced by soluble factors and triggers increases in expression of senescence-associated molecules such as p53, p21, and p16. Importantly, these T cells are not only phenotypically altered, but also functionally altered as they can suppress the proliferation of responder T cells. This suppression requires cell-to-cell contact and is mediated by senescent CD4(+) and CD8(+) subpopulations, which are distinct from classically described natural T regulatory cells. Our observations support the novel concept that tumor can induce senescent T cells with suppressor function and may effect both the diagnosis and treatment of cancer.
Abstract 6450: Circulating hepsin as a novel serum biomarker in prostate cancer patients (2020)

Abstract Hepsin, a type II transmembrane serine protease, is commonly overexpressed in a variety of epithelial cancers, where its overexpression and concurrent proteolytic activity correlate with tumor progression. Recent studies indicate that Hepsin undergoes activation via autocatalysis and subsequent ectodomain shedding, thus highlighting its potential as a serum-based biomarker. Using transgenic mouse models of prostate adenocarcinoma, Hepsin overexpression has previously been implicated in disease progression and, notably, metastases that are neuroendocrine in nature. Collectively, these findings led us to explore the potential diagnostic utility of Hepsin expression in prostate cancer progression, inclusive of metastatic variants. Here, we reanalyzed pre-existing, publicly available gene expression datasets (2 datasets, 326 patient samples), which revealed a significant upregulation of Hepsin gene expression in tumor tissue versus benign tissue and further pronounced upregulation in androgen-dependent and -independent metastatic lesions. To further examine the potential correlation of Hepsin overexpression to androgen-independence, we reanalyzed in vitro data comparing LNCaP parental versus androgen-independent LNCaP subclones. This analysis revealed a stepwise increase in Hepsin expression over the course of androgen deprivation, which was accompanied by a concomitant decrease in PSA expression. Lastly, to evaluate circulating hepsin protein levels as they occur in patient serum, a total of 424 subjects suspected of prostate cancer were analyzed for circulating Hepsin levels from 2015 to 2018 at the time of biopsy and followed for recurrence or survival until the end of the study. Serum Hepsin levels, as determined by enzyme-linked immunosorbent assay, rendered a specificity of 89% (Gleason &amp;lt; 6 (3+3); Hepsin positive, &amp;gt;100 ng/mL). Within this cohort, 18 patients presented with biochemical recurrence, of which 44% were Hepsin positive and exhibited a 22-month accelerated clinical path to recurrence versus Hepsin negative patients. Collectively, these results highlight the longitudinal diagnostic potential of circulating Hepsin levels in the prostate cancer setting. Citation Format: John Beard, Sam Eddington, Noah Bowman, Adam Cole, Timothy O'Brien, Blake P. Johnson. Circulating hepsin as a novel serum biomarker in prostate cancer patients [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 6450.
Novel Role for Matrix Metalloproteinase 9 in Modulation of Cholesterol Metabolism (2016)

Our results show that MMP-9 modulates cholesterol metabolism, at least in part, through a novel MMP-9-plasma secreted phospholipase A<sub>2</sub> axis that affects the hepatic transcriptional responses to dietary cholesterol. Furthermore, the data suggest that dysregulation of the MMP system can result in metabolic disorder, which could lead to atherosclerosis and coronary heart disease.