gebhart/patrepeval huggingface dataset:
Multi‐centre prospective randomised controlled clinical trial to evaluate a bioactive split thickness skin allograft vs standard of care in the treatment of diabetic foot ulcers (2022)

Diabetic foot ulcers (DFUs) pose a significant risk for infection and limb loss. Advanced wound therapies including human skin allografts have shown promise in resolving these challenging wounds. The primary objective of this randomised, prospective study was to compare the response of 100 subjects with non-healing DFUs of which 50 were treated with a cryopreserved bioactive split thickness skin allograft (BSA) (TheraSkin; Misonix,Inc., Farmingdale, NY) compared with 50 subjects treated with standard of care (SOC, collagen alginate dressing) at 12 weeks. Both groups received standardised care that included glucose monitoring, weekly debridement's as appropriate, and an offloading device. The primary endpoint was proportion of full-thickness wounds healed at 12 weeks, with secondary endpoints including differences in percent area reduction (PAR) at 12 weeks, changes in Semmes-Weinstein monofilament score, VAS pain, and w-QoL. The result illustrated in the intent-to-treat analysis at 12 weeks showed that 76% (38/50) of the BSA-treated DFUs healed compared with 36% (18/50) treated with SOC alone (adjusted P = .00056). Mean PAR at 12 weeks was 77.8% in the BSA group compared with 49.6% in the SOC group (adjusted P = .0019). In conclusion, adding BSA to SOC appeared to significantly improve wound healing with a lower incidence of adverse events related to treatment compared with SOC alone.
Anucleate Cell Blue Assay: a Useful Tool for Identifying Novel Type II Topoisomerase Inhibitors (2005)

About 95,000 compounds were screened by the anucleate cell blue assay. Fifty-one of the hit compounds had various structures and showed inhibitory activity against DNA gyrase and/or topoisomerase IV. Moreover, the compounds exhibited antibacterial activity against a fluoroquinolone- and novobiocin-resistant strain of Staphylococcus aureus. The anucleate cell blue assay is therefore a useful tool for finding novel type II topoisomerase inhibitors.
Kinetic model for alcohol synthesis over a promoted copper/zinc oxide/chromium oxide (Cr2O3) catalyst (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic model for alcohol synthesis over a promoted copper/zinc oxide/chromium oxide (Cr2O3) catalystEdward M. Calverley and Kevin J. SmithCite this: Ind. Eng. Chem. Res. 1992, 31, 3, 792–803Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March 1992https://pubs.acs.org/doi/10.1021/ie00003a023https://doi.org/10.1021/ie00003a023research-articleACS PublicationsRequest reuse permissionsArticle Views390Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MR angiography of the foot and ankle (1995)

To better understand the use of magnetic resonance angiography (MRA) in evaluating peripheral vascular disease, the authors studied arteries in the foot and ankle. Twenty patients with arterial occlusive disease of the lower extremity were studied with two-dimensional time-of-flight MRA, and the results were compared with those of 10 conventional x-ray arteriograms, four digital subtraction arteriograms, and three intraoperative arteriograms. The studies were reviewed and rated by three radiologists blinded to the patients' clinical history. Also, the first 16 patients were examined with MRA before and after intravenous injection of gadopentetate dimeglumine. The mean confidence levels for the reviewers' interpretations of the MRA studies were significantly higher than those for the conventional arteriograms for the medial plantar, lateral plantar, and plantar arch arteries of the feet (P < or = .005). Postcontrast MRA images were inferior to precontrast images because of overlapping of veins and arteries. Time-of-flight MRA without gadolinium can serve as a useful complementary study for evaluating patients with peripheral vascular disease in the foot and ankle.
A Systematic Approach to Improve Communication for Emergency Response (2009)

The importance of communication, information sharing and interoperability in an emergency response scenario have risen recently based on the frequency of disasters throughout the world and the wide range of severities and degrees of impacts. This work contributes to the area of emergency response communication qualitatively by presenting a systematic approach to develop an organizational communication model to improve overall emergency response. Establishing and accessing a reliable communication infrastructure at crisis is crucial in order to have accurate and real-time exchange of information. This work identifies a set of potential network oriented problems in existing inter-organizational communication protocols incorporating the information collected at several drill participations and interviewing the first responders. We conquer the complexity of a large, unique and unpredictable emergency response process by a top-down approach. We are constructing a high-level hierarchical Petri net consisting of decoupled individual organizations gathered at a crisis site to model the interactions among different jurisdictions. This abstracts each organization as a sub-block in the overall model which provides flexibility in study at a high-level while does not involve with the details. We present organizational challenges on communication technology and inter-organizational communication protocols identified during the drill.
<i><scp>STX</scp>11</i> functions as a novel tumor suppressor gene in peripheral T‐cell lymphomas (2015)

Peripheral T-cell lymphomas (PTCL) are a heterogeneous group of non-Hodgkin lymphomas with poor prognosis. Their molecular pathogenesis has not been entirely elucidated. We previously showed that 6q24 is one of the most frequently deleted regions in primary thyroid T-cell lymphoma. In this study, we extended the analysis to other subtypes of PTCL and performed functional assays to identify the causative genes of PTCL that are located on 6q24. Genomic loss of 6q24 was observed in 14 of 232 (6%) PTCL cases. The genomic loss regions identified at 6q24 always involved only two known genes, STX11 and UTRN. The expression of STX11, but not UTRN, was substantially lower in PTCL than in normal T-cells. STX11 sequence analysis revealed mutations in two cases (one clinical sample and one T-cell line). We further analyzed the function of STX11 in 14 cell lines belonging to different lineages. STX11 expression only suppressed the proliferation of T-cell lines bearing genomic alterations at the STX11 locus. Interestingly, expression of a novel STX11 mutant (p.Arg78Cys) did not exert suppressive effects on the induced cell lines, suggesting that this mutant is a loss-of-function mutation. In addition, STX11-altered PTCL not otherwise specified cases were characterized by the presence of hemophagocytic syndrome (67% vs 8%, P = 0.04). They also tended to have a poor prognosis compared with those without STX11 alteration. These results suggest that STX11 plays an important role in the pathogenesis of PTCL and they may contribute to the future development of new drugs for the treatment of PTCL.
Prostate Cancer Cells Express More Androgen Receptor (AR) Following Androgen Deprivation, Improving Recognition by AR-Specific T Cells (2017)

Androgen deprivation is the primary therapy for recurrent prostate cancer, and agents targeting the androgen receptor (AR) pathway continue to be developed. Because androgen-deprivation therapy (ADT) has immmunostimulatory effects as well as direct antitumor effects, AR-targeted therapies have been combined with other anticancer therapies, including immunotherapies. Here, we sought to study whether an antigen-specific mechanism of resistance to ADT (overexpression of the AR) may result in enhanced AR-specific T-cell immune recognition, and whether this might be strategically combined with an antitumor vaccine targeting the AR. Androgen deprivation increased AR expression in human and murine prostate tumor cells <i>in vitro</i> and <i>in vivo</i> The increased expression persisted over time. Increased AR expression was associated with recognition and cytolytic activity by AR-specific T cells. Furthermore, ADT combined with vaccination, specifically a DNA vaccine encoding the ligand-binding domain of the AR, led to improved antitumor responses as measured by tumor volumes and delays in the emergence of castrate-resistant prostate tumors in two murine prostate cancer models (Myc-CaP and prostate-specific PTEN-deficient mice). Together, these data suggest that ADT combined with AR-directed immunotherapy targets a major mechanism of resistance, overexpression of the AR. This combination may be more effective than ADT combined with other immunotherapeutic approaches. <i>Cancer Immunol Res; 5(12); 1074-85. ©2017 AACR</i>.
In Situ ATR–SEIRAS of Carbon Dioxide Reduction at a Plasmonic Silver Cathode (2020)

Illumination of a voltage-biased plasmonic Ag cathode during CO<sub>2</sub> reduction results in a suppression of the H<sub>2</sub> evolution reaction while enhancing CO<sub>2</sub> reduction. This effect has been shown to be photonic rather than thermal, but the exact plasmonic mechanism is unknown. Here, we conduct an in situ ATR-SEIRAS (attenuated total reflectance-surface-enhanced infrared absorption spectroscopy) study of a sputtered thin film Ag cathode on a Ge ATR crystal in CO<sub>2</sub>-saturated 0.1 M KHCO<sub>3</sub> over a range of potentials under both dark and illuminated (365 nm, 125 mW cm<sup>-2</sup>) conditions to elucidate the nature of this plasmonic enhancement. We find that the onset potential of CO<sub>2</sub> reduction to adsorbed CO on the Ag surface is -0.25 V<sub>RHE</sub> and is identical in the light and the dark. As the production of gaseous CO is detected in the light near this onset potential but is not observed in the dark until -0.5 V<sub>RHE</sub>, we conclude that the light must be assisting the desorption of CO from the surface. Furthermore, the HCO<sub>3</sub><sup>-</sup> wavenumber and peak area increase immediately upon illumination, precluding a thermal effect. We propose that the enhanced local electric field that results from the localized surface plasmon resonance (LSPR) is strengthening the HCO<sub>3</sub><sup>-</sup> bond, further increasing the local pH. This would account for the decrease in H<sub>2</sub> formation and increase the CO<sub>2</sub> reduction products in the light.
Strong and tough micro/nanostructured poly(lactic acid) by mimicking the multifunctional hierarchy of shell (2014)

The present work discloses a bioinspired methodology for the unprecedented achievement of simultaneously strong, tough and stiff PLA.
Continuous Global N-Tuple Coverage with (2N = 2) Satellites (1989)

Abstract : This report is annotated briefing covering research on arrays or constellations of satellites giving n-tuple continuous, global-line-of-sight coverage of a planet using the minimum number of satellites. A generalized theory was developed which appears to fit cases for any level of redundancy. Except for the case for single coverage, which is a tetrahedral array, all of the constellations can be characterized as either skew- or congruent-prismoidal arrays. The constellation altitudes increase with increasing levels of redundancy. Keywords: Satellites; Constellations; Coverage; Continuous coverage; Global coverage; Minimum satellite coverage; Arrays; Networks.
Pharmacokinetics of a Prototype Formulation of Sublingual Testosterone and a Buspirone Tablet, Versus an Advanced Combination Tablet of Testosterone and Buspirone in Healthy Premenopausal Women (2014)

The study aimed to compare the kinetics of two novel combination drug products for Female Sexual Interest/Arousal Disorder (FSIAD). Thirteen women received testosterone via the sublingual route followed 2.5 hours later by a buspirone tablet, versus a single combination tablet swallowed at once. The first clinical prototype consisted of a sublingual solution containing testosterone (0.5 mg) complexed with cyclodextrin and a tablet containing 10 mg buspirone, in a gelatin capsule to ensure blinding during the clinical studies. The innovative fixed-combination tablet consists of an inner-core component of 10 mg buspirone coated with a polymeric time-delay coating and an outer polymeric coating containing testosterone with hydroxypropyl-beta cyclodextrin. We observed an immediate testosterone pulse absorption from both formulations. We also demonstrated that there was adequate absorption of buspirone (>80 % relative to the conventional tablet) and a time delay in release of buspirone of 3.3 hours, close to the 3.0 hours of the reference formulation that showed clinical efficacy in early proof-of-principle studies. The newly developed combination tablet fulfils its design criteria and is a convenient tablet for further clinical studies in FSIAD.
Direct Preparation of Transparent Isotactic Polypropylene with Supported Ziegler–Natta Catalysts Containing Novel Eco-friendly Internal Electron Donors (2020)

This study reported novel eco-friendly Ziegler–Natta catalysts containing bioderived maleic rosinate tri-n-butyl and maleic rosinate tri-n-octyl as internal electron donors for propylene polymerization to obtain transparent isotactic polypropylene. Surprisingly, on the one hand, rosin acid esters can function as internal electron donors to improve the stereoselectivity of the catalyst where the isotacticity of polypropylene obtained reaches 97.85%. On the other hand, they act as nucleating agents to greatly improve the transparency of polypropylene, with a light transmittance of 93.8% and haze of 4.4%, due to internal electron donors evenly dispersed on the surface of the catalyst particles. Furthermore, the catalysts were used to carry out propylene polymerization and showed the highest catalytic activity value of 31.9 kgPP·gCat–1·h–1.
Cholesterol modification of Hedgehog family proteins (2002)

basis of cholesterol modification of HhHh is produced as an approximately 46-kDa precursor.In addition to the removal of the signal peptide, it is
Quantification of global transcription patterns in prokaryotes using spotted microarrays (2007)

We describe an analysis, applicable to any spotted microarray dataset produced using genomic DNA as a reference, that quantifies prokaryotic levels of mRNA on a genome-wide scale. Applying this to Mycobacterium tuberculosis, we validate the technique, show a correlation between level of expression and biological importance, define the complement of invariant genes and analyze absolute levels of expression by functional class to develop ways of understanding an organism's biology without comparison to another growth condition.
Statistical Compressed Sensing of Gaussian Mixture Models (2011)

A novel framework of compressed sensing, namely statistical compressed sensing (SCS), that aims at efficiently sampling a collection of signals that follow a statistical distribution, and achieving accurate reconstruction on average, is introduced. SCS based on Gaussian models is investigated in depth. For signals that follow a single Gaussian model, with Gaussian or Bernoulli sensing matrices of <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">O</i> ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> ) measurements, considerably smaller than the <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">O</i> ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> log( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> / <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> )) required by conventional CS based on sparse models, where <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">N</i> is the signal dimension, and with an optimal decoder implemented via linear filtering, significantly faster than the pursuit decoders applied in conventional CS, the error of SCS is shown tightly upper bounded by a constant times the best <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> -term approximation error, with overwhelming probability. The failure probability is also significantly smaller than that of conventional sparsity-oriented CS. Stronger yet simpler results further show that for any sensing matrix, the error of Gaussian SCS is upper bounded by a constant times the best <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> -term approximation with probability one, and the bound constant can be efficiently calculated. For Gaussian mixture models (GMMs), that assume multiple Gaussian distributions and that each signal follows one of them with an unknown index, a piecewise linear estimator is introduced to decode SCS. The accuracy of model selection, at the heart of the piecewise linear decoder, is analyzed in terms of the properties of the Gaussian distributions and the number of sensing measurements. A maximization-maximization (Max-Max) algorithm that iteratively estimates the Gaussian models parameters, the signals model selection, and decodes the signals, is presented for GMM-based SCS. In real image sensing applications, GMM-based SCS is shown to lead to improved results compared to conventional CS, at a considerably lower computational cost.
Effect of chemical oxidation on the gas sensing properties of multi-walled carbon nanotubes (2008)

The effect of chemical oxidation on the gas sensing properties of multi-walled carbon nanotubes (MWNT) is presented in this paper. The MWNT was chemically oxidized in a mixture of concentrated sulfuric and nitric acids. The oxidation time was varied from 4 to 12 hours. X-ray photoelectron spectroscopy (XPS) was used to study effect on the chemical composition of the nanotube surface. The MWNT was deposited onto gas sensor substrate by drop coating method. The gas sensing properties of samples with different oxidation time for NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> were investigated at room temperature. Comparing with the as-obtained MWNT, the gas sensitivity of functionalized MWNT was greatly increased for both NO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> and NH <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> .
Novel high resolution MOEMS inclination sensor (2014)

Inclination sensors are essential elements in many different fields of application such as navigation, metrology, geodetics, geoscience, as well as in the consumer market. In general, for high precision navigation. The sensor's resolution is one of the key parameters to improve the performance and to open up new areas of applications. The implementation of a miniaturized optical readout is one of the most promising ways to accomplish this goal. This paper discusses the principle of a novel inclination sensor along with obtained measurements of two prototypes with different mechanical parameters. The achieved sensitivity is 0.044 V/° resulting in an angular resolution of 0.0051°.
Mutation of the Diamond-Blackfan Anemia Gene Rps7 in Mouse Results in Morphological and Neuroanatomical Phenotypes (2013)

The ribosome is an evolutionarily conserved organelle essential for cellular function. Ribosome construction requires assembly of approximately 80 different ribosomal proteins (RPs) and four different species of rRNA. As RPs co-assemble into one multi-subunit complex, mutation of the genes that encode RPs might be expected to give rise to phenocopies, in which the same phenotype is associated with loss-of-function of each individual gene. However, a more complex picture is emerging in which, in addition to a group of shared phenotypes, diverse RP gene-specific phenotypes are observed. Here we report the first two mouse mutations (Rps7(Mtu) and Rps7(Zma)) of ribosomal protein S7 (Rps7), a gene that has been implicated in Diamond-Blackfan anemia. Rps7 disruption results in decreased body size, abnormal skeletal morphology, mid-ventral white spotting, and eye malformations. These phenotypes are reported in other murine RP mutants and, as demonstrated for some other RP mutations, are ameliorated by Trp53 deficiency. Interestingly, Rps7 mutants have additional overt malformations of the developing central nervous system and deficits in working memory, phenotypes that are not reported in murine or human RP gene mutants. Conversely, Rps7 mouse mutants show no anemia or hyperpigmentation, phenotypes associated with mutation of human RPS7 and other murine RPs, respectively. We provide two novel RP mouse models and expand the repertoire of potential phenotypes that should be examined in RP mutants to further explore the concept of RP gene-specific phenotypes.
The Diagnosis and Initial Treatment of Patellofemoral Disorders. (2018)

Our purpose is to provide simple guidelines for the diagnosis and early care of patellofemoral disorders. Any clinician who treats knee problems, including family practitioners, rheumatologists, orthopedic surgeons, or physical therapists, must know how to make the correct diagnosis, or at least a presumptive diagnosis, at the initial visit. This can avoid unneeded and costly tests, ineffective treatment, and even damaging exercises and unnecessary surgery. The diagnosis of patellofemoral disorders is confusing because they can have many causes. That is, the etiology of patellofemoral disorders is multifactorial. To dispel this confusion and simplify the process, we use a clinical classification based on etiology. Within that framework are 7 key abnormalities or factors that can cause both patellofemoral pain and instability: vastus medialis obliquus deficiency, medial patellofemoral ligament laxity, lateral retinaculum tightness, increased quadriceps angle, hip abductor weakness, patella alta, and trochlear dysplasia. At the initial evaluation, the clinician can assess for these abnormalities through history-taking, physical examination, and standard radiography. Any abnormalities identified, along with their severity, can be used to arrive at a diagnosis, or a presumptive diagnosis, and begin early nonoperative treatment. The clinician does not need magnetic resonance imaging at this point, unless a presumptive diagnosis cannot be made or a more complex problem is suggested.