gebhart/patrepeval huggingface dataset:
Review Article Electrical Storms in Brugada Syndrome: Review of Pharmacologic and Ablative Therapeutic Options (2005)

Electrical storm occurring in a patient with the Brugada syndrome is an exceptional but malignant and potentially lethal event. Efficient therapeutic solutions should be known and urgently applied because of the inability of usual antiarrhythmic means in preventing multiple recurrences of ventricular arrhythmias. Isoproterenol should be immediately infused while oral quinidine should be further administrated when isoproterenol is not effective. In case of failure of these therapeutic options, ablation of the triggering ventricular ectopies should be attempted
Structure and Reactivity of Lithiated α-Amino Nitriles (1998)

Investigations aimed at elucidating the structure of lithiated α-amino nitriles B have led to the identification of N-lithio α-amino nitrile anions as characteristic structural features. Their preparations, crystal structures, and solution structures under the reaction conditions, are described. X-ray crystal structure analyses of crystalline 3 and (S, S)-4 reveal the presence of dimeric aggregates B4 with Ci symmetry, held together by four-membered NLiNLi rings, coordinatively saturated at lithium by four THF ligands. The crystal structure of (S, S)-6 shows polymeric aggregation with dimeric subunits similar to those of 3 and (S, S)-4. The solution structure has been investigated by IR and Raman spectroscopy of 2, (S, S)-4 and (S, S)-6, by NMR spectroscopy of 3, (S, S)-5 and (S, S)-6, and by cryoscopic measurements of (S, S)-6 in THF. Trapping experiments complement the results. In THF, which constitutes the principal reaction medium, the lithiated amino nitriles B are found to exist as monomeric species B6 between −110 and +25°C. In less polar solvents, higher aggregation is presumed. NMR spectroscopic studies of 3 show that the favored orientations of the amine and phenyl groups are similar to their conformations in the solid state. In the light of the results obtained, a transition state is proposed to account for the relative topicity observed in the 1,4-additions of enantiopure lithiated α-amino nitriles (S, S)-4, (S, S)-5, and (S, S)-6 to Michael acceptors.
ChemInform Abstract: Envirocat EPZG® as a New Heterogeneous Catalyst for the Efficient Synthesis of Conjugated Nitroolefins. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Atypical manifestations of gastroesophageal reflux disease. (2005)

Gastroesophageal reflux disease (GERD) may manifest typically with heartburn and regurgitation or atypically as laryngitis, asthma, cough, or noncardiac chest pain. The diagnosis of these atypical manifestations may be difficult for primary care physicians because most patients do not have heartburn or regurgitation. Diagnostic tests have low specificity and it is difficult to establish a cause-and-effect association between GERD and atypical symptoms. Response to aggressive acid suppression is often the most commonly employed initial tool to indicate GERD etiology in a patient with atypical symptoms.
Structural stability and renormalization group for propagating fronts (1994)

A solution to a given equation is structurally stable if it suffers only an infinitesimal change when the equation (not the solution) is perturbed infinitesimally. We have found that structural stability can be used as a velocity selection principle for propagating fronts. We give examples, using numerical and renormalization group methods.
Application of two-dimensional velocity profile to three-dimensionalboundary-layer flow (1986)

The problem of excessive resultant velocity by using a two-dimensional profile for the streamwise flow in three dimensions is addressed. To be consistent with the physics of the boundary layer, it is proposed that the twodimensional profile be applied to the resultant flow instead of the streamwise flow. An integral boundary-layer procedure based on the new velocity profile for theoretically determining the vortex-type flow separation is developed. The procedure is applicable to cases with large crossflows. The calculated theoretical results are compared with those obtained using the previous method, which is based on the power-law profile as applied to the streamwise flow, as well as with the available experimental data.
Purifying viruses with a sheet of paper: Single-use steric exclusion chromatography as a capture platform for vaccine candidates (2018)

Author: Marichal-Gallardo, Pavel et al.; Genre: Meeting Abstract; Published in Print: 2018; Title: Purifying viruses with a sheet of paper: Single-use steric exclusion chromatography as a capture platform for vaccine candidates
Public Safety Communications above 6 GHz: Challenges and Opportunities (2017)

Advanced public safety communication (PSC) services call for fast, reliable and low-latency communication technologies, capable of supporting diverse communication modes (aerial, unmanned, vehicular, and peer-to-peer), fast channel dynamics, and ad hoc or mesh structures. For this reason, PSC has been identified as one of the key potential uses cases for the next generation of communication systems, the so-called 5G. In this scenario, the millimeter wave (mmWave) bands and other frequencies above 6 GHz are particularly interesting, since they are largely untapped and offer vastly more spectrum than current cellular allocations in the highly congested bands below 6 GHz, thus enabling orders of magnitude greater data rates and reduced latency. For example, new PSC networks in the mmWave bands could support high-definition video, virtual reality, and other broadband data to large numbers of first responders. Surveillance drones or ambulances could also be provided high-speed connectivity along with machine-type communication for remotely controlled robotic devices entering dangerous areas. However, the way towards this ambitious goal is hindered by a number of open research challenges. In this paper, after a brief introduction to PSC services and requirements, we illustrate the potential of the frequencies above 6 GHz for PSC and discuss the open problems that need to be solved in order to pave this way. Finally, we describe the main components of a test platform for mmWave systems that is functional to the study of such complex scenarios and that we plan to develop as an invaluable tool for realizing mmWave PSC networks.
Electrochromic Solid-State Devices Using Organic-Metallic Hybrid Polymers (2008)

Organic-metallic hybrid polymers are formed by the complexation of metal ions with organic modules bearing two coordination sites. The hybrid polymers consisting of bis-terpyridines and metal ions such as Fe(II) or Ru(II) have a specific color based on the metal-to-ligand charge transfer (MLCT) absorption. Cyclic voltammograms of the polymers exhibit a reversible redox wave according to the redox reaction of the metal ions. Interestingly, a polymer film cast on an indium tin oxide (ITO) electrode exhibits excellent electrochromic properties; the color of the film disappears when a higher potential as compares to the redox potential of the metal ions is applied to the polymer film. In addition, multicolor electrochromic changes appear on introducing two types of metal ions to the polymer. Electrochromic solid-state devices are successfully fabricated by using these polymers.
Abstract 12573: A Hybrid Artificial Intelligence-Intrinsic Frequency Method for Instantaneous Detection of Acute Myocardial Infarction (2019)

Introduction: We recently introduced a novel systems-based approach, the Intrinsic Frequency (IF) method, for noninvasive evaluation of the cardiovascular dynamics using non-calibrated arterial pre...
Reduced mucociliary clearance in old mice is associated with a decrease in muc5b mucin (2020)

infections are a major cause of morbidity and mortality in the elderly. Previous reports have suggested that mucociliary clearance (MCC) is impaired in older individuals, but the cause is unclear. To unravel the mechanisms responsible for the age-associated decline in MCC, we investigated the MCC system in young (3 mo) and old (2 yr) C57BL/6 mice. We found that old mice had significantly reduced MCC function in both the upper and lower airways compared with young mice. Measurement of bioelectric properties of isolated tracheal and bronchial tissue revealed a significant decrease in Cl- secretion, suggesting that the older mice may have a reduced ability to maintain a sufficiently hydrated airway surface for efficient MCC. Ciliary beat frequency was also observed to be reduced in the older animals; however, this reduction was small relative to the reduction in MCC. Interestingly, the level of the major secreted mucin, Muc5b, was found to be reduced in both bronchioalveolar lavage and isolated tracheal tissue. Our previous studies of Muc5b-/- mice have demonstrated that Muc5b is essential for normal MCC in the mouse. Furthermore, examination of Muc5b+/- and wild-type animals revealed that heterozygous animals, which secrete ∼50% of the wild-type level of Muc5b, also demonstrate a markedly reduced level of MCC, confirming the importance of Muc5b levels to MCC. These results demonstrate that aged mice exhibit a decrease in MCC and suggest that a reduced level of secretion of both Cl- and Muc5b may be responsible.
Region-based Pornographic Image Detection (2005)

Recent advantages in digital images and networks have made pornographic images more accessible than ever. Methods of detecting pornographic images have been proposed in some existing work. However, the skin detection modules adopted are all pixel-based and skin region shape features are rarely properly used. This paper presents a framework for pornographic image detection based on skin region information. Different from traditional works, our approach extracts color and texture features from arbitrary-shaped segmented regions. Then Gaussian mixture models are built for skin and non-skin region classification, and the skin map is produced based on the classification result. Finally, eigenregion features are used to describe the layout of skin regions on the whole image and pornographic images are detected according to the skin modality
Lysosomal enzyme phosphorylation in mouse lymphoma cell lines with altered asparagine-linked oligosaccharides. (1982)

The targeting of acid hydrolases to lysosomes involves phosphorylation of mannose residues on these enzymes.To determine whether alterations in the structure of the oligosaccharide acceptor affect formation of the mannose 6-phosphate recognition marker, two mouse lymphoma cell lines altered in the assembly of asparagine-linked oligosaccharides were studied.Cells were labeled with [2-3 H]mannose and the phosphorylated oligosaccharides were isolated and characterized.PhaR2.7 cells, which are deficient in glucosidase II activity, formed less oligosaccharide-bound mannose 6-phosphate than parent cells.The major phosphorylated oligosaccharide formed by Pha R 2 ' 7 contained a single phosphodiester located on the branch linked al,6 to the fl-linked mannose; the majority of these molecules were glucosylated.Relatively few oligosaccharides containing two phosphate esters were isolated and those formed were not glucosylated.This suggests that glucose residues present on high mannose oligosaccharides prevent phosphorylation of mannose residues on the branch linked al,3 to the Bf-linked mannose.In contrast, Thy-1-cells synthesized a normal level of oligosaccharide-bound mannose 6-phosphate despite forming truncated, high mannose-type units.These oligosaccharides contained only four mannose residues and a single phosphate, present as either a phosphodiester or phosphomonoester.,f-Galactosidase isolated from Thy-1-cells bound to human fibroblast membranes and was endocytosed by intact fibroblasts to a similar extent as parent enzyme.These findings demonstrate that altered high mannose-type oligosaccharides on lysosomal enzymes are phosphorylated.However, the extent of phosphorylation and the distribution of the esters is dependent upon the structure of the acceptor oligosaccharide.In addition, the presence of monophosphorylated oligosaccharides on acid hydrolases is sufficient for their recognition and translocation by the mannose 6-phosphate receptor.In many cell types the targeting of newly synthesized acid hydrolases to lysosomes is mediated by phosphomannosyl residues present on high mannose-type oligosaccharide units
Study of the relaxation of strain in patterned Si/SiGe structures using an x-ray diffraction technique (2006)

We present an investigation of a series of samples with strained stripe-patterned SiGe layers grown on a Si substrate. The strain in the SiGe striped epilayers was calculated after measuring the lattice constants of the layers using an x-ray diffraction technique. It was found that the stripes showed an anisotropic strain in the two in-plane directions resulting from the lattice mismatch and the difference in the dimensions of the stripes. The idea is based on the concept of enhancing the hole mobility in subsequent Si cap layers due to anisotropy of the stain in the patterned SiGe layers.
Frontispiece: Homochiral MOF–Polymer Mixed Matrix Membranes for Efficient Separation of Chiral Molecules (2019)

Mixed-Matrix Membranes In their Research Article on page 16928, H. Zhang, H. Wang et al. report the synthesis of homochiral mixed matrix membranes show excellent enantioselectivity for racemic 1-phenylethanol by incorporation of MOFs into a polymer matrix.
An investigator-initiated monocentric phase I dose escalation trial of temsirolimus and irinotecan (TEMIR) in patients with relapsing glioblastoma multiforme (reGBM). (2012)

2086 Background: Deregulation of the PI3K/AKT pathway has been preclinically involved in the pathophysiology of GBM. The mammalian target of rapamycin (mTOR) is an important downstream mediator of PI3K/AKT signalling. The mTOR-inhibitor temsirolimus (Tem) achieves significant drug levels in brain. Thus, Tem may be effectively combined with irinotecan (Iri) which has shown promising results in combination with bevacizumab in patients (pts) with reGBM refractory to temozolomide (Tmz) in phase II. Exposure to Tem as well as Iri is substantially reduced in pts receiving CYP3A4 enzyme-inducing anticonvulsants (CYP3A4-Ind). Methods: TEMIR is a phase I trial of escalating doses of Tem in combination with Iri in pts with reGBM refractory to Tmz depending on the cotreatment with CYP3A4-Ind. In pts without CYP3A4-Ind dose escalation of Tem was performed according to the “3+3 protocol” from 15 via 20 to 25 mg iv wkly together with 85 mg/m 2 Iri iv wkly. In pts with CYP3A4-Ind the doses of Tem were 30, 40 and 50 mg iv wkly together with 170 mg/m 2 Iri iv wkly, respectively. The determination of the pharmacokinetics (PK) of Tem and its influence on the PK of Iri and its active metabolite SN38 was performed by validated RP-HPLC methods with fluorescence detection. Results: Up to now, 14 pts [4 female and 10 male, median age 47 yrs (range 41-65 yrs), 9 without and 5 with CYP3A4-Ind] have been treated. All 9 pts without CYP3A4-Ind (3 pts on 15, 20 and 25 mg Tem each) are evaluable for safety with only mild toxicity [highest CTC-grade ≥2 (gr) per pt]: diarrhea 4 (gr2) and 1 (gr3), neutropenia 1 (gr3), thrombopenia 1 (gr2), anemia 1 (gr2), pneumonia 2 (gr2), rash 1 (gr2). PK parameters of Iri and SN38 were in agreement with previously published studies and there was no significant effect of 15 to 25 mg Tem combined with 85 mg/m 2 Iri on the PK of Iri and SN38. In 7 pts evaluable for efficacy there was no remission (RECIST) and median time to symptomatic and/or MRT progression was 10 wks (7, 9+, 10, 10+, 11, 15, 20 wks). Conclusions: The combination of Tem in standard dose of 25 mg iv wkly with 85 mg/m 2 Iri wkly is safe in pts with reGBM without CYP3A4-Ind. Tem has no significant effect on the PK of Iri and SN38.
ChemInform Abstract: Tandem Transformations Initiated by the Migration of a Silyl Group. Some New Synthetic Applications of Silyloxiranes (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
2219 A method for calculating volume for casting defects using X ray CT data (2009)

Calculating volume of defects in casting objects is important for high quality manufacturing. However, conventional methods cannot detect tiny defects, because not only their CT value does not fall down to the value of background but also they appear like one set in CT images. As a result, we do not take into account such tiny defects and their calculation accuracy is comparatively low. In this paper, we propose a quantitative method to calculate casting defects' volume. We define two types of defect by their size and apply different calculation models to each defect and also propose a method to separate each defect from the set of defects. As a result, we can handle all defects which are appeared in CT images. This paper also demonstrates quantitative estimation of defects' volume using measured CT data.
Self‐Assembly and Electrical Conductivity Transitions in Conjugated Oligoaniline–Surfactant Complexes (2004)

Funktionell und extern steuerbar sind elektroaktive Nanostrukturen, die durch Selbstorganisation von ionischen Bausteinen entstehen. Die kolumnaren Strukturen (siehe Bild) bestehen aus rechteckigen Oligoanilin-Baueinheiten und Phosphattensiden mit zwei Kohlenwasserstoffketten. Beim Erhitzen bricht die Ordnung der tetrameren Anilinkomplexe zusammen, und die 2D-Struktur geht reversibel in einen ungeordneten Zustand über. Dieser Prozess ist mit einer Änderung der elektrischen Leitfähigkeit verbunden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z460928_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Barceloneic Acid A, a New Farnesyl-Protein Transferase Inhibitor from a Phoma Species (1995)

Three new diphenyl ethers, barceloneic acids A, B, and barceloneic lactone [1, 2, and 3, respectively] were isolated from a fermentation extract of a fungus of the genus Phoma. The structures of compounds 1-3 were determined by a combination of spectroscopic and single-crystal X-ray diffraction methods. The effect of these compounds on the inhibition of farnesyl-protein transferase (FPTase) was evaluated and results are presented. Barceloneic acid A [1] is a novel and modest inhibitor of FPTase with an IC50 value of 40 microM.
Biphasic regulation of plasminogen activator/inhibitor by LDL in mesangial cells (2002)

Lipid abnormalities and dysregulation of the plasminogen activator (PA)/plasmin system may be involved in the development of glomerulosclerosis. We investigated the effects of low-density lipoprotein (LDL) on PA inhibitor-1 (PAI-1), urokinase-type PA (uPA), and tissue-type PA (tPA) in relationship to protein kinase C (PKC) in cultured human mesangial cells (HMC). LDL (200 microg/ml) induced two peaks of PKC activation at hours 0.25 and 6, with translocation of PKC-alpha, -beta(1), and -delta from cytosol to the membrane. The second increase in PKC activity gradually decreased to the control value by hour 18. LDL downregulated 2.4-kb PAI-1, uPA, and tPA mRNA expression within 6 h of incubation with HMC. On the other hand, after 12-48 h, LDL-treated cells showed a significant increase in PAI-1, tPA, and uPA mRNA levels. LDL induced up to a twofold increase in PAI-1 antigen levels in the extracellular matrix of HMC after 24-48 h as well as increased PA inhibitory activity in the culture medium. Analysis of the adhesion plaques from cells incubated with LDL for 48 h by zymography showed increased intensity of lysis near molecular weights of approximately 55,000 and 100,000. LDL slightly increased tPA release at hours 24 and 48 but did not increase PA activity in culture medium. The stimulatory effects of LDL on PAI-1, tPA, and uPA gene regulation in HMC were blocked by the inhibition of PKC using GF-109203X 12 h after treatment with LDL or downregulation of PKC using phorbol myristate acetate. In summary, LDL regulates PAI-1, uPA, and tPA in biphasic patterns in HMC, and the upregulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed PKC activation associated with an increased PA inhibitory activity. These results suggest that LDL, after prolonged incubations with HMC, causes a PA/inhibitor imbalance favoring accumulation of matrix.
Molecular Mechanisms of Hepatocarcinogenesis in Transgenic Mouse Models of Liver Cancer (2005)

Overexpression of c-myc and transforming growth factor-alpha (TGF-alpha) has been frequently observed in human hepatocellular carcinoma (HCC),suggesting a pivotal role played by these protooncogenes in liver oncogenesis. In order to investigate the molecular events underlying human hepatic malignant transformation, we have generated c-myc and c-myc/ TGF-alpha transgenic mice that are prone to liver cancer. These transgenic mice develop HCCs with different incidence, kinetics and histopathological features. Indeed, co-expression of c-myc and TGF-alpha transgenes results in a dramatic synergistic effect on liver tumor development when compared with respective single transgenic lines, including a shorter latency period and a more aggressive phenotype. The more malignant histopathological features characteristic of c-myc/ TGF-alpha HCCs are the result of the increased proliferation and reduced apoptosis in this model of liver cancer when compared with single parental lines. Accordingly, c-myc and c-myc/l TGF-alpha transgenic mice display a different molecular pathogenesis of HCC. Importantly, the genetic and molecular mechanisms that are involved in c-myc and c-myc/ TGF-alpha liver cancer development are major oncogenic events in human hepatocarcinogenesis, indicating that these mouse models represent a useful tool to dissect and elucidate the molecular basis of human HCC.