gebhart/patrepeval huggingface dataset:
Noninvasive Estimation of Arterial Viscoelastic Indices Using a Foil-type Flexible Pressure Sensor and a Photoplethysmogram (2011)

This paper proposes a noninvasive method for estimating the viscoelastic characteristics of arterial walls using pulse waves measured in various parts of the body using a foil-type pressure sensor (FPS) and a photoplethysmogram. The FPS was employed to measure pulse waves based on the tonometry approach for its characteristics of high sensitivity and flexibility as well as its ability to continuously measure the alternating-current component of pulse waves. First, in order to accurately measure the amplitude variation of blood pressure waves, suitable mechanical forces externally applied to the FPS were examined, and it was found that values of 5 - 25 (N) yielded the best performance. Next, to verify the time characteristics of pulse waves, the brachial-ankle pulse wave velocity (baPWV) was measured. The results showed that baPWV determined using the FPS and that found with a noninvasive vascular screening device were almost the same. Estimation was then performed to establish arterial viscoelastic indices for the radial artery and the dorsal pedis artery during the application of mechanical pain stimuli. The results suggested that the estimated indices could be used to quantitatively assess vascular response caused by sympathicotonia. Thus, it was concluded that the proposed method enabled noninvasive measurement of pulse waves and estimation of viscoelastic indices.
Structured Prediction by Conditional Risk Minimization (2016)

We propose a general approach for supervised learning with structured output spaces, such as combinatorial and polyhedral sets, that is based on minimizing estimated conditional risk functions. Given a loss function defined over pairs of output labels, we first estimate the conditional risk function by solving a (possibly infinite) collection of regularized least squares problems. A prediction is made by solving an inference problem that minimizes the estimated conditional risk function over the output space. We show that this approach enables, in some cases, efficient training and inference without explicitly introducing a convex surrogate for the original loss function, even when it is discontinuous. Empirical evaluations on real-world and synthetic data sets demonstrate the effectiveness of our method in adapting to a variety of loss functions.
Experimental evidence of VO−Zni complex to be intrinsic donor in bulk ZnO (2014)

Theoretical evidence of VO−Zni to be a native donor in bulk ZnO has been under debate. To resolve the issue, we annealed several pieces of as grown zinc rich n-type ZnO thin film having ND ∼ 3.26 × 1017 cm−3 grown by molecular beam epitaxy on Si (001) substrate in oxygen environment at 500°C – 800°C, keeping a step of 100°C for one hour, each. Room temperature Hall measurements demonstrated that free donor concentration decreased exponentially and Arrhenius plot yielded activation energy to be 1.2±0.02 eV. This value is in an agreement with the theoretically reported activation energy of VO−Zni donor complex in ZnO.
Development of a New Class of Nonimidazole Histamine H<sub>3</sub> Receptor Ligands with Combined Inhibitory Histamine <i>N-</i>Methyltransferase Activity (2002)

In search of novel ways to enhance histaminergic neurotransmission in the central nervous system, a new class of nonimidazole histamine H(3) receptor ligands were developed that simultaneously possess strong inhibitory activity on the main histamine metabolizing enzyme, histamine N-methyltransferase (HMT). The novel compounds contain an aminoquinoline moiety, which is an important structural feature for HMT inhibitory activity, connected by different spacers to a piperidino group (for H(3) receptor antagonism). Variation of the spacer structure provides two different series of compounds. One series, having only an alkylene spacer between the basic centers, led to highly potent HMT inhibitors with moderate to high affinity at human histamine H(3) receptors. The second series possesses a p-phenoxypropyl spacer, which may be extended by another alkylene chain. This latter series also showed strong inhibitory activity on HMT, and in most cases, the H(3) receptor affinity even surpassed that of the first series. One of the most potent compounds with this dual mode of action is 4-(4-(3-piperidinopropoxy)phenylamino)quinoline (34) (hH(3), K(i) = 0.09 nM; HMT, IC(50) = 51 nM). This class of compounds showed high antagonist potency and good H(3) receptor selectivity in functional assays in guinea pig on H(1), H(2), and H(3) receptors. Because of low or missing in vivo activity of two selected compounds, the proof of concept of these valuable pharmacological tools for the supposed superior overall enhancing effect on histaminergic neurotransmission failed to appear hitherto.
Multiple‐pulse stimulation and dantrolene in malignant hyperthermia (1990)

A potentially fatal condition, yet preventable, malignant hyperthermia (MH) lacks a satisfactory noninvasive diagnostic test. Studying the effects of intravenous dantrolene (3 mg/kg) on electrically stimulated skeletal muscle, we found that this approach does not conclusively distinguish between normal humans and those susceptible to malignant hyperthermia but nonetheless yielded important information about the action of dantrolene in man and in MH. Supramaximal single- and multiple-pulse stimulation of the common peroneal nerve produced stable torque responses of the dorsiflexor muscles (monitored in vivo), which dantrolene suppressed. With the multiple-pulse stimulation (5-6 pulses) this torque suppression was significantly less in MH-susceptible subjects than in control subjects. This distinction, also observed in MH swine, confirms this animal as a good model for human MH. That dantrolene's effect in MH can be more completely reversed with high frequency stimulation is intriguing; presumably, excitation-contraction coupling differs in MH and normal muscle.
128Gb/s DP-QPSK silicon modulator module integrated with driver amplifiers (2014)

We report a compact dual-polarization quadrature phase-shift keying (DP-QPSK) modulator module accommodating a silicon DP-QPSK modulator chip and driver amplifiers in a package in a dimension of 15×35×4.5 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> . 128-Gb/s DP-QPSK transmission in 1000-km single-mode fibre is confirmed with the compact modulator module.
Beta Transforming Growth Factors (TGFβ) at the Porcine Conceptus-Maternal Interface. Part I: Expression of TGFβ1, TGFβ2, and TGFβ3 Messenger Ribonucleic Acids1 (1998)

Spatial and temporal mRNA expression of beta transforming growth factors (TGFbeta1, TGFbeta2, and TGFbeta3) in porcine uterus and conceptuses was determined during the peri-implantation period (Days 10-14 of gestation). Northern blotting identified a major 3. 5-kilobase (kb) and a minor 2.5-kb transcript for TGFbeta1 mRNA. TGFbeta2 transcripts were 6.2 kb, 5.4 kb, and 2.7 kb, and a single 3. 5-kb transcript was detected for TGFbeta3. With semiquantitative in situ hybridization analysis, progressive increases were detected in TGFbetas 1, 2, and 3 mRNA expression in uterine luminal epithelium (ULE), uterine glands (UGs), and underlying stroma (stroma spongiosum, SS) from Days 10 through 14 of gestation (p < 0.05). In myometrium, TGFbeta mRNA expression did not differ between Days 10 through 14 of gestation. In porcine conceptuses, TGFbetas 1, 2, and 3 mRNA expression was detected in trophectoderm, endoderm, embryonic ectoderm, and mesoderm. For the three TGFbeta isoforms examined, mRNA expression increased 2- to 4-fold in trophectoderm and endoderm between Days 10 and 14 of gestation. TGFbeta1 mRNA levels increase significantly in embryonic ectoderm, but not mesoderm, between Days 12 and 14 of gestation; during that same time, TGFbeta2 mRNA levels increased, but no change was detected in TGFbeta3 mRNA levels, in embryonic ectoderm and mesoderm. Progressive increases in TGFbeta mRNA expression in conceptus trophectoderm, endoderm, ULE, UGs, and SS suggest important roles for these growth factors in porcine conceptus development during the peri-implantation period.
Dialogue between <i>E. coli</i> free radical pathways and the mitochondria of <i>C. elegans</i> (2015)

The microbial world presents a complex palette of opportunities and dangers to animals, which have developed surveillance and response strategies to hints of microbial intent. We show here that the mitochondrial homeostatic response pathway of the nematode Caenorhabditis elegans responds to Escherichia coli mutations that activate free radical detoxification pathways. Activation of C. elegans mitochondrial responses could be suppressed by additional mutations in E. coli, suggesting that C. elegans responds to products of E. coli to anticipate challenges to its mitochondrion. Out of 50 C. elegans gene inactivations known to mediate mitochondrial defense, we found that 7 genes were required for C. elegans response to a free radical producing E. coli mutant, including the bZip transcription factor atfs-1 (activating transcription factor associated with stress). An atfs-1 loss-of-function mutant was partially resistant to the effects of free radical-producing E. coli mutant, but a constitutively active atfs-1 mutant growing on wild-type E. coli inappropriately activated the pattern of mitochondrial responses normally induced by an E. coli free radical pathway mutant. Carbonylated proteins from free radical-producing E. coli mutant may directly activate the ATFS-1/bZIP transcription factor to induce mitochondrial stress response: feeding C. elegans with H2O2-treated E. coli induces the mitochondrial unfolded protein response, and inhibition of a gut peptide transporter partially suppressed C. elegans response to free radical damaged E. coli.
Ion energy spectra analyzers for magnetized plasma (1999)

Ion energy spectra analyzers for investigation of plasma in an axial magnetic field are considered. These analyzers can measure the velocity spectra of the magnetized ion components of dense plasma. The small inlet hole method is used in presented analyzers for spatial separation of electron and ion flows. The construction and operating features of these analyzers are described. The described analyzers have been used for measurements of ion parameters of plasma flow with magnetized titanium ions generated by the universal plasma source. Experimental results are presented and discussed.
Induction dosing of peginterferon alfa-2a (40 KD) and/or high-dose ribavirin in genotype 1 CHC patients with difficult-to-treat characteristics: pharmacokinetic and viral kinetic (PK/VK) assessment from PROGRESS. (2015)

Early viral de clines may be enhanced with the 360 μg dose. These data may suggest the utility of high-dose peginterfer on alfa-2a plus direct-acting antivirals (DAA) in select difficult-to-treat populations.
Evaluation of the Respimat Soft Mist Inhaler using a Concurrent CFD and <i>In Vitro</i> Approach (2008)

It was found that the aerosol generated from the highly complex process of jet collision and breakup could be approximated in the model using effective spray conditions. Computational predictions of deposition fractions agreed well with in vitro results for both the IP (within 20% error) and MT (within 10% error) geometries. The experimental results indicated that the deposition fraction of drug in the MP ranged from 27 to 29% and accounted for a majority of total drug loss. Based on the CFD solution, high MP deposition was due to a recirculating flow pattern that surrounded the aerosol spray and entrained a significant number of small droplets. In contrast, deposition of the Respimat aerosol in both the IP (4.2%) and MT (7.4%) geometries was relatively low. Results of this study indicate that modifications to the current Respimat MP and control of specific patient variables may significantly reduce deposition in the device and may decrease high oropharyngeal drug loss observed in vivo.
Photodocumentation of Corneal Scarring (1996)

The corneal photography protocol we describe is recommended for use in clinical investigations of cicatricizing corneal disease and appears robust enough to be used in multicenter studies.
Mesophases and crystalline phases in fatty acid monolayers (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleMesophases and crystalline phases in fatty acid monolayersR. M. Kenn, C. Boehm, A. M. Bibo, I. R. Peterson, H. Moehwald, J. Als-Nielsen, and K. KjaerCite this: J. Phys. Chem. 1991, 95, 5, 2092–2097Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://doi.org/10.1021/j100158a034RIGHTS & PERMISSIONSArticle Views599Altmetric-Citations277LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (718 KB) Get e-Alerts
ANALYSIS OF UNEXPECTED INHIBITIONS OF T LYMPHOCYTE PROLIFERATION TO SOLUBLE ANTIGEN, ALLOANTIGEN AND MITOGEN BY UNFRAGMENTED ANTI‐I‐A<sup>k</sup> OR ANTI‐I‐E/C<sup>k</sup> MONOCLONAL ANTIBODIES (1982)

We investigated the capacity of anti-I-Ak and anti-I-E/Ck monoclonal antibodies (m.Ab.) to inhibit T lymphocyte proliferative responses to soluble antigen (Keyhole limpet hemocyanin), alloantigens (H-2 or non-H-2 related) and a mitogen (Concanavalin A). Surprisingly, specific inhibition was observed in all circumstances, and with both anti-I-Ak and anti-I-E/Ck m.Ab., whether the responses tested were I restricted in cell mixing experiments or not. The significance of the inhibition by anti-Ia m.Ab. of non-Ia-restricted responses is still not completely understood. These results, however, strongly suggest that in vitro inhibition by anti-Ia antibodies of T cell proliferative responses does not necessarily indicate I restriction of the presentation to T lymphocytes of the corresponding antigen.
A novel bispecific <scp>DARP</scp>in targeting Fcγ<scp>RIIB</scp> and Fcε<scp>RI</scp>‐bound IgE inhibits allergic responses (2016)

The described bispecific DARPin protein has the ability to co-ligate FcγRIIB with FcεRI-bound IgE on allergic effector cells and represents an efficient dual-modality to interfere with allergic hypersensitivity reactions.
Figure S2 from Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer (2023)

&lt;p&gt;Tumor cell-derived IL-1b regulates stromal immune cell profile and IL-1b production.&lt;/p&gt;
Adsorption Chemistry of Sulfur Dioxide in Hydrated Na–Y Zeolite (2004)

Außergewöhnlich widerstandsfähig gegen eine Vergiftung durch Schwefel ist der Na-Y-Zeolith. Als Grund wurde die Lokalisierung von adsorbiertem Schwefeldioxid am Zeolith in Gegenwart von Wasser identifiziert (siehe Bild; H2SO3: gelbe (S) und große rote Kugeln (O); Zeolithgerüst: kleine rote (O) und graue Kugeln (Si oder Al); große graue Kugel: Na).
Comparative study of fully pre-cross-connected protection architectures for transparent optical networks (2007)

Protection architectures that have the property of pre-cross-connection are advantageous to the implementation of transparent optical paths. A pre-cross-connected protection path can be in a known-good working condition before use, whereas on-the-fly assembly of a protection path through transparent concatenation of optical channels may not rapidly satisfy the optical path integrity objective. In this study, several pre-cross-connected architectures were compared on the basis of spare capacity cost for 100% single failure restorability, the dual failure restorability of these designs, and the ability of each architecture to support a feasible wavelength assignment and limits on the maximum length of transparent optical paths. The architectures considered were p-cycles, failure independent path-protecting (FIPP) p-cycles, demand-wise shared protection (DSP), pre-cross-connected trails (PXTs), span-protecting p-trees, and path-protecting p-trees. The results give insight into the relative merits and demerits of these architectures.
Efficient WDM optical crossconnect using widely tunable FBGs (2000)

Summary form only given. Wavelength-division-multiplexed (WDM) optical crossconnects will be highly useful in future reconfigurable optical networks. Conventional architectures for WDM crossconnects using (de)multiplexers and space switches can be quite expensive and the components are not generally of high filtering quality. Fiber Bragg gratings (FBGs) offer an attractive option in WDM routing systems because FBGs: (a) are fiber compatible with low loss, and low cost, (b) have high spectral selectivity, thereby enabling narrow channel spacing, and (c) exhibit high reflectivity, thereby ensuring good crosstalk suppression. We demonstrate a WDM crossconnect that uses the wide tuning range of ultra-strong FBGs. The crossconnect uses cascades of FBGs, in which the FBGs can be tuned completely out of the WDM signal band resulting in low crosstalk and power penalty.
Endogenous IL-13 Plays a Crucial Role in Liver Granuloma Maturation During Leishmania donovani Infection, Independent of IL-4Rα–Responsive Macrophages and Neutrophils (2011)

Previous studies comparing interleukin 4 receptor α (IL-4Rα)(-/-) and interleukin 4 (IL-4)(-/-) BALB/c mice have indicated that interleukin 13 (IL-13), whose receptor shares the IL-4Rα subunit with IL-4, plays a protective role during visceral leishmaniasis. We demonstrate that IL-13(-/-) BALB/c mice were less able to control hepatic growth of Leishmania donovani compared with wild-type mice. This correlated with significantly retarded granuloma maturation in IL-13(-/-) mice, defective interferon γ (IFN-γ) production, and elevated IL-4 and interleukin 10 (IL-10) levels. L. donovani-infected IL-13(-/-) mice also responded poorly to sodium stibogluconate-mediated chemotherapy compared with wild-type BALB/c mice. Because murine lymphocytes do not have IL-13 receptors, we examined the ability of macrophage/neutrophil-specific IL-4Rα(-/-) mice to control primary infection with L. donovani and to respond to chemotherapy. Macrophage/neutrophil-specific IL-4Rα(-/-) mice were as resistant to leishmaniasis as wild-type mice, and chemotherapy retained its efficacy. Consequently, in L. donovani infected BALB/c mice, IL-13 promotes hepatic granuloma formation and controls parasite burdens independently of direct effects on macrophages/neutrophils.
A nonsense mutation in the apolipoprotein C-IIPadova gene in a patient with apolipoprotein C-II deficiency. (1989)

The apo C-II gene from a patient with apo C-II deficiency has been sequenced after amplification by the polymerase chain reaction. A substitution of an adenosine for a guanosine at position 3002 in exon 3 of the patient's gene was identified by sequence analysis. This mutation leads to the introduction of a premature termination codon (TAA) at a position corresponding to amino acid 37 of mature apo C-II and to the formation of a new Rsa I restriction enzyme site not present in the normal apo C-II gene. Amplification of DNA from family members by the polymerase chain reaction and digestion with Rsa I established that the patient is a true homozygote for the mutation. Analysis of the patient's plasma by two-dimensional gel electrophoresis and immunoblotting detected an apo C-II that exhibited abnormal electrophoretic mobility. We propose that the C to A substitution in the apo C-IIPadova gene is the primary genetic defect that leads to premature termination and the synthesis of a truncated 36 amino acid apo C-II that is unable to activate lipoprotein lipase.
Anomaly-sensitive dictionary learning for structural diagnostics from ultrasonic wavefields (2015)

This paper proposes a strategy for the detection and triangulation of localized anomalies, such as defects, inclusions, or damage zones, in solid and structural media. The method revolves around the construction of sparse representations of the structure's ultrasonic wavefield response, which are obtained by learning instructive dictionaries that form a suitable basis for the response data. The resulting sparse coding problem is cast as a modified dictionary learning task with additional spatial sparsity constraints enforced on the atoms of the learned dictionaries, which provide them with the ability to unveil anomalous regions in the physical domain. The proposed methodology is model-agnostic, i.e., it forsakes the need for a physical model and requires virtually no a priori knowledge of the material properties. This characteristic makes the approach especially powerful for anomaly identification in systems with unknown or highly heterogeneous property distribution, for which a material model is unsuitable or unreliable. The method is tested against synthetically generated data as well as experimental data acquired using a scanning laser Doppler vibrometer.
Acoustic radiation from periodic and sectionally aperiodic rib-stiffened plates (1994)

The far-field and near-field solutions for the radiated acoustic pressure from a line-driven fluid-loaded, rib-stiffened thin elastic plate have been obtained. The plate has been configured to have two sets of rib stiffeners, though the formulation given has been extended to include additional rib-stiffener sets. The stiffeners composing a given set are identical and are spaced periodically with distance l. However, one set of stiffeners is shifted by an amount Δ from the other set. In this manner, portions of the plate may be configured with periodic repeating sections of arbitrary length l having aperiodic rib spacing. The stiffeners exert reactive forces upon the plate, but not angular moments. Fluid loading is included on the upper surface of the plate while the lower surface is unloaded, except for a time harmonic line force applied normal to the lower surface. The far-field radiated pressure has been obtained using the method of stationary phase. Numerical integration techniques were used to obtain the near-field acoustic pressure.
Light-mediated discovery of surfaceome nanoscale organization and intercellular receptor interaction networks (2020)

Abstract Delineating the molecular nanoscale organization of the surfaceome is pre-requisite for understanding cellular signaling. Technologies for mapping the spatial relationships of cell surface receptors and their extracellular signaling synapses would open up theranostic opportunities and the possibility to engineer extracellular signaling. Here, we developed an optoproteomic technology termed LUX-MS that exploits singlet oxygen generators (SOG) for the light-triggered identification of acute protein interactions on living cells. Using SOG-coupled antibodies, small molecule-drugs, biologics and intact viral particles, we show that not only ligand-receptor interactions can be decoded across organisms, but also the surfaceome receptor nanoscale organization ligands engage in with direct implications for drug action. Furthermore, investigation of functional immunosynapses revealed that intercellular signaling inbetween APCs and CD8 + T cells can be mapped now providing insights into T cell activation with spatiotemporal resolution. LUX-MS based decoding of surfaceome signaling architectures provides unprecedented molecular insights for the rational development of theranostic strategies.