gebhart/patrepeval huggingface dataset:
Optical scrambling system for document authentication by image decryption (2019)

The continuous development of new authentication techniques is necessary to prevent illegal data access from unauthorized users or counterfeiting. In this paper, we present a simple optical method to decode encrypted images using a multi-scopic optical system. The method uses a scrambled lens-let array which provides a high level of security. In a simple configuration, the encrypted image is scrolled in front of the multi-scopic imaging system. Due to a particular arrangement of lens-lets, the image will only be correctly imaged at a unique position with respect to the imager. Experimental demonstrations are presented and potential applications discussed.
The Effect of Chronic Exposure to Fatty Acids on Gene Expression in Clonal Insulin-Producing Cells: Studies Using High Density Oligonucleotide Microarray (2001)

Fatty acids affect insulin secretion of pancreatic beta-cells. Investigating gene expression profiles may help to characterize the underlying mechanism. INS-1 cells were cultured with palmitate (0, 50, and 200 microM) for up to 44 d. Insulin secretion and expressions of 8740 genes were studied. We found that basal insulin secretion increased in cells exposed to palmitate. The response to glucose stimulation declined on d 44 in cells cultured at 200 microM palmitate. In response to 50 and 200 microM palmitate exposure, expression was changed in 11 and 99 genes on d 2 and 134 and in 159 genes on d 44, respectively. Genes involved in fatty acid oxidation were up-regulated, whereas those involved in glycolysis were down-regulated with 200 microM palmitate. A suppression of insulin receptor and insulin receptor substate-2 gene expression was found on d 44 in cells cultured at 200 microM palmitate. In conclusion, chronic exposure to low palmitate alters insulin secretion as well as gene expression. The number of genes that changed expression was palmitate dose and exposure time dependent. Randle's fatty acid-glucose cycle seems to be operative on the gene transcription level. A modification of expression of various genes may contribute to the functional changes.
Effects of Methotrexate on Rabbit Testes Part 1: Morphological Changes (1986)

Methotrexate (MTX) has the potential of eradicating small infiltrations of leukemic cells in the gonads. We examined the morphological changes in rabbit testes after a single dose (57.5 mg/kgBW) or repeated low doses (6 mg/kgBW once a week for 14 weeks) of MTX IV. Fertility rate and spermatogenic activity were evaluated using the tubular fertility index (TFI). Testicular MTX concentrations (measured by RIA) were in the same range in both groups. Only after repeated MTX application were reduction of TFI and signs of germinal cell line degeneration found. When given repetitively, MTX therapy may modify the fertility and tubular morphology. Long-term follow-up will show how these changes affect future fertility.
Reduction of Interface Reactions in the Low-Temperature Solid-Phase Epitaxy of ScAlMgO<sub>4</sub> on Al<sub>2</sub>O<sub>3</sub>(0001) (2020)

Low-temperature solid-phase epitaxy is a promising route for the synthesis of thin films of ScAlMgO4, a compound with lattice spacings close to compound semiconductors for which there are no practical lattice-matched bulk substrates. Amorphous ScAlMgO4 films deposited by sputtering on c-plane sapphire, Al2O3(0001), were crystallized by subsequent heating. Crystallization at 950 °C resulted in the formation of epitaxial ScAlMgO4 from the initially amorphous layer over a period of 10 h. The epitaxial film exhibits an epitaxial arrangement in which ScAlMgO4[0001] is parallel to Al2O3[0001] and ScAlMgO4[1120] is parallel to Al2O3[1120]. The as-deposited ScAlMgO4 films had a nonstoichiometric composition, and thus regions of MgAl2O4 were produced during crystallization at 950 °C. Crystallization at a higher temperature, 1400 °C, resulted in unfavorable solid-state reactions between the thin film and the substrate, producing MgAl2O4 and ScAlO3.
Optical-feedback-stabilized quantum cascade laser frequency combs (2019)

Stabilization of quantum-cascade-laser frequency combs by means of external optical feedback is presented. Experimental results suggest reduced phase-noise in the frequency comb, allowing comb operation in previously unstable regimes.
Plötzliche Abnahme der Wirksamkeit von UV-Cross-Linking (CXL) bei sehr hohen UV-Bestrahlungsstärken und kurzen Bestrahlungszeiten (2013)

Zielsetzung: Die Standardbehandlung bei fortschreitender Keratektasie ist UV-Cross-Linking (CXL). Für Bestrahlungsstärken über 10mW/cm2 und entsprechende Bestrahlungszeiten von unter 10 Minuten fehlt ein wissenschaftlicher Beweis für die Festigkeitszunahme in Hornhautgewebe.[for full text, please go to the a.m. URL]
Stem Cell-Mediated Exon Skipping of the Dystrophin Gene by the Bystander Effect (2015)

Duchenne muscular dystrophy (DMD) is characterized by the loss of a functional dystrophin protein; the muscles of DMD patients progressively degenerate as a result of mechanical stress during contractions, and the condition eventually leads to premature death. By means antisense oligonucleotides (AONs), it is possible to modulate pre-mRNA splicing eliminating mutated exons and restoring dystrophin open reading frame. To overcome the hurdles in using AONs for therapeutic interventions, we exerted engineered human DMD stem cells with a lentivirus, which permanently and efficiently delivered the cloned AONs. Here we describe for the first time the exosome-mediated release of AONs from engineered human DMD CD133+ stem cells allowing the rescue of murine dystrophin expression. Finally, upon release, AONs could be internalized by host cells suggesting a potential role of exosomes acting as vesicular carriers for DMD gene therapy.
Arabidopsis leucine-rich repeat extensin (LRX) proteins modify cell wall composition and influence plant growth (2015)

LRX3, LRX4, and LRX5, and most likely LRX proteins in general, are important for cell wall development. Due to the complexity of changes in cell wall structures in the lrx mutants, the exact function of LRX proteins remains to be determined. The increasingly strong growth-defect phenotypes in double and triple mutants suggests that the LRX proteins have similar functions and that they are important for proper plant development.
Metalation, a Novel Route for the Functionalization of Reactive Elastomers. 1. Superbases in the Metalation of Poly(isobutylene-<i>co</i>-<i>p</i>-methylstyrene) (1996)

A variety of strong bases and hydrocarbon-soluble superbases (SB) have been used for the selective metalation of poly(isobutylene-co-p-methylstyrene) at the benzylic p-methyl position. The reaction was monitored by quenching the metalated polymer with chlorotrimethylsilane and measuring the resulting functionalization by 1H NMR spectrometry. A study of different SB's prepared from butyllithium and a heavier alkali metal alkoxide showed the importance of the alkali metal used in the alkoxide. Both the degree of metalation and the selectivity increase with the size of the metal cation (Li+ < Na+ < K+ < Cs+). Best results for the quantitative metalation of all of the benzylic p-methyl groups of the copolymer were obtained using a 2-fold molar excess of the SB derived from s-BuLi and cesium l-(−)-menthoxide in the ratio of 1:3. Ring metalation is estimated to less than 2%, and the polymer backbone is unreactive. Time-dependent metalation reactions carried out between −78 and +65 °C reveal that, regardless of the reaction temperature, maximum metalation takes place in less than 2 min. Other superbases such as [(trimethylsilyl)methyl]potassium or alkali metal amides exhibit negligible reactivities under the reaction conditions used.
The evolving role of confocal microscopy combined with optical coherence tomography to guide Mohs surgery: early adoption at the bedside (2020)

Advances in pre-operative mosaicking of basal cell carcinoma margins in vivo with combined reflectance confocal microscopy-and-optical coherence tomography and intra-operative margins ex vivo with combined reflectance-and-fluorescence confocal microscopy to guide Mohs surgery will be presented.
Cu-Speciation in Dehydrated CHA Zeolites Studied by H<sub>2</sub>-TPR and In Situ EPR (2023)

H2-temperature-programmed reduction (TPR) and electronic paramagnetic resonance (EPR) spectroscopy are widely used to quantify two families of Cu-species in dehydrated Cu-CHA zeolites, namely, Z2Cu (Cu associated with two Al in the 6-ring) and ZCuOH (Cu associated with one Al). Since quantification is not straightforward, discrepancies arise between investigations based on only one method. Five samples with the same parent zeolite material were investigated with different amounts of copper using both H2-TPR and EPR to elaborate on the possible quantification of Cu-sites. Proper quantification of the Z2Cu sites required simulation of the EPR spectra and analysis of the Gaussian fit of the H2-TPR data for each family of species. To reach an agreement between EPR and H2-TPR on the quantification of Z2Cu sites, the two high-temperature reduction peaks in the TPR (ca. 350 and 530 °C) were added together. The composite low-temperature reduction peak in TPR (ca. 215 and 250 °C) is speculated to consist of different types of ZCuOH where some are EPR silent and some give a broad and indistinct EPR spectrum. Our analysis shows that the amount of Cu in the most stable sites, Z2Cu, is close to the amount predicted by the assumption of a random distribution of Al in the framework. However, the hyperfine coupling pattern of the EPR spectra reveals that within the category of Z2Cu sites, a non-even distribution exists between the two possible types in this particular CHA zeolite. H2-TPR combined with in situ EPR further reveals that one of the Z2Cu sites is more easily reduced than the other.
Correcting for heterogeneous fluence profiles in photoacoustic imaging with diffuse optical tomography (2010)

Diffuse optical tomography and photoacoustic tomography were combined to measure the optical absorption coefficient of a tissue mimicking phantom. Heterogeneous fluence maps were calculated from DOT absorption reconstructions and used to correct PAT reconstructions.
Chemical Syntheses and Biological Activities of Lactam Analogues of α-Conotoxin SI<sup>,</sup><sup>,</sup> (2000)

Bicyclization represents an effective method for the introduction of conformational constraints into small, biologically important peptides. Several strategies have been developed for the preparation of bicyclic lactam analogues of alpha-conotoxin SI, a 13-residue peptide neurotoxin found in cone snail venom. Four analogues of the natural regioisomer of alpha-conotoxin SI were designed and synthesized, each with one of the two paired cysteines of the parent peptide being replaced by a side-chain lactam bridged glutamic acid/lysine pair. Solid-phase lactamization was studied to determine rates of formation of the two possible loops and to document the extent of dimerization and higher oligomerization. Radioligand binding assays were carried out on all synthesized peptides, including the naturally occurring two-disulfide form, in order to determine their affinities for nicotinic acetylcholine receptors (nAChRs). Replacement of the Cys(2)-Cys(7) loop of alpha-conotoxin SI with a lactam bridge resulted in complete loss of activity, whereas replacement of the Cys(3)-Cys(13) disulfide loop resulted in a approximately 60-fold reduction in affinity for one orientation and a approximately 70-fold increase in affinity for the other. The two active lactam analogues retain the selectivity exhibited by the naturally occurring peptide for the alpha/delta subunit of nAChRs, as judged by competition experiments with the curariform antagonist metocurine.
A Stackelberg Game for Incentive Proactive Caching Mechanisms in Wireless Networks (2016)

In this paper, an incentive proactive cache mechanism in cache-enabled small cell networks (SCNs) is proposed, in order to motivate the content providers (CPs) to participate in the caching procedure. A network composed of a single mobile network operator (MNO) and multiple CPs is considered. The MNO aims to define the price it charges the CPs to maximize its revenue while the CPs compete to determine the number of files they cache at the MNO's small base stations (SBSs) to improve the quality of service (QoS) of their users. This problem is formulated as a Stackelberg game where a single MNO is considered as the leader and the multiple CPs willing to cache files are the followers. The followers game is modeled as a non-cooperative game and both the existence and uniqueness of a Nash equilibrium (NE) are proved. The closed-form expression of the NE which corresponds to the amount of storage each CP requests from the MNO is derived. An optimization problem is formulated at the MNO side to determine the optimal price that the MNO should charge the CPs. Simulation results show that at the equilibrium, the MNO and CPs can all achieve a utility that is up to 50% higher than the cases in which the prices and storage quantities are requested arbitrarily.
Three-Dimensional Effects and Collapse Resistance Mechanisms in Steel Frame Buildings (2013)

This study investigates the robustness of a seismically designed steel moment frame building using 3-D nonlinear models. Computational simulations are carried out using validated models to investigate building response to loss of internal and external columns as well as columns in lower, middle and upper floors. Studies are conducted to gain insight into the sources of collapse resistance of the prototype building, focusing in particular on the role of composite action between the slab and underlying steel beams and slab membrane action. The simulation results suggest that the prototype building can be more vulnerable to loss of columns in the upper stories than in the lower ones and is particularly vulnerable to loss of interior gravity columns at all floor levels. The role of the slab is quantified and it is shown that it can contribute significantly to the robustness of the structure, but it is a double edge sword that can also be detrimental, especially in the final stages of collapse.
Low‐Power and Field‐Free Perpendicular Magnetic Memory Driven by Topological Insulators (2023)

Giant spin-orbit torque (SOT) from topological insulators (TIs) has great potential for low-power SOT-driven magnetic random-access memory (SOT-MRAM). In this work, a functional 3-terminal SOT-MRAM device is demonstrated by integrating the TI [(BiSb)<sub>2</sub> Te<sub>3</sub> ] with perpendicular magnetic tunnel junctions (pMTJs), where the tunneling magnetoresistance is employed for the effective reading method. An ultralow switching current density of 1.5 × 10<sup>5</sup> A cm<sup>-2</sup> is achieved in the TI-pMTJ device at room temperature, which is 1-2 orders of magnitude lower than that in conventional heavy-metals-based systems, due to the high SOT efficiency θ<sub>SH</sub> = 1.16 of (BiSb)<sub>2</sub> Te<sub>3</sub> . Furthermore, all-electrical field-free writing is realized by the synergistic effect of a small spin-transfer torque current during the SOT. The thermal stability factor (Δ = 66) shows the high retention time (>10 years) of the TI-pMTJ device. This work sheds light to the future low-power, high-density, and high-endurance/retention magnetic memory technology based on quantum materials.
Broadband Data Transmission in a 40 GHz Fiber Radio Link using a Dual-Wavelength SBS Fiber Laser (2009)

We generate narrow-linewidth 40 GHz signals using a dual-wavelength SBS fiber laser. Data encoding at bit rates &gt; 1 Gb/s is also presented with 1 Gb/s data transmission in a 40 GHz wireless link demonstrated.
CWSF radar for detecting small UAVs (2017)

Since the number of flying small unmanned aerial vehicles (UAV) is expected to increase dramatically in the next years, their radar detection has become a priority. In this paper Continuous Wave Step Frequency (CWSF) is evaluated as possible modulation for radar sensors aimed to detect small quadcopters at short range.
<i>Vinca</i> Alkaloids in Superacidic Media:  A Method for Creating a New Family of Antitumor Derivatives (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTVinca Alkaloids in Superacidic Media: A Method for Creating a New Family of Antitumor DerivativesJacques Fahy, Alain Duflos, Jean-Paul Ribet, Jean-Claude Jacquesy, Christian Berrier, Marie-Paule Jouannetaud, and Fabien ZuninoView Author Information Division de Chimie Médicinale V Département de Chimie Analytique Centre de Recherche Pierre Fabre 81106-Castres, France Laboratoire de Synthèse et Réactivité des Substances Naturelles, UMR 6514 Université de Poitiers, 86022-Poitiers, France Cite this: J. Am. Chem. Soc. 1997, 119, 36, 8576–8577Publication Date (Web):September 10, 1997Publication History Received6 June 1997Published online10 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/ja971864whttps://doi.org/10.1021/ja971864wrapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views1110Altmetric-Citations131LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Anions,Chemical reactions,Ions,Organic compounds,Reaction products Get e-Alerts
Process requirements for pitch splitting LELE double patterning at advanced logic technology node (2012)

As IC dimensions continue to shrink beyond the 22nm node, optical single exposure cannot sustain the resolution required and various double patterning techniques have become the main stream prior to the availability of EUV lithography. Among various kinds of double patterning techniques, positive splitting pitch lithography-etch-lithographyetch (LELE) double patterning is chosen for printing complex foundry circuit designs. Tighter circuit CD and process margin control in such positive splitting pitch LELE double patterning process becomes increasingly critical especially for topography issues induced by the 1st mask patterning with the 2nd mask exposure. In this paper, laser parameters, topography issues with the 2nd mask exposure, and SMO effects on CD performances are described in terms of the proximity CD portion of the scanner CD budget. Laser parameters, e.g. spectral shape and bandwidth, were input into the photolithography simulator, Prolith, to calculate their impacts on circuit CD variation. Mask-bias dependent lithographic performance was calculated and used to illustrate the importance of well-controlled laser performance parameters. Recommended laser bandwidth, mask bias and topography requirements are proposed, based on simulation results to ensure that the tight CD control (&lt; 1nm) required for advanced technology node products can be achieved.
Identification of a novel fusion, SQSTM1-ALK, in ALK-positive large B-cell lymphoma (2010)

ALK-positive large B-cell lymphoma is a rare subtype of lymphoma, and most cases follow an aggressive clinical course with a poor prognosis. We examined an ALK-positive large B-cell lymphoma case showing an anti-ALK immunohistochemistry pattern distinct from those of 2 known ALK fusions, CLTC-ALK and NPM-ALK, for the presence of a novel ALK fusion; this led to the identification of SQSTM1-ALK. SQSTM1 is an ubiquitin binding protein that is associated with oxidative stress, cell signaling, and autophagy. We showed transforming activities of SQSTM1-ALK with a focus formation assay and an in vivo tumorigenicity assay using 3T3 fibroblasts infected with a recombinant retrovirus encoding SQSTM1-ALK. ALK-inhibitor therapies are promising for treating ALK-positive large B-cell lymphoma, especially for refractory cases. SQSTM1-ALK may be a rare fusion, but our data provide novel biological insights and serve as a key for the accurate diagnosis of this rare lymphoma.
Use of Human Fibrin Glue (Tissucol) Versus Staples for Mesh Fixation in Laparoscopic Transabdominal Preperitoneal Hernioplasty (2007)

Fortelny, René H. MD; Glaser, Karl S. MD; Petter-Puchner, Alexander H. MD Author Information
Nearly transform limited pulses from a gain-switched InGaAsP distributed-feedback laser using polarization dispersion effect (1994)

Due to the large change of carrier density during the pulse emission, gain-switched distributed feedback semiconductor lasers suffer from a large frequency chirp that can extend over several nanometers. As the chirp is generally nonlinear, it is difficult to achieve transform limited pulses after a linear compression stage. We demonstrate here that polarization dispersion can be used to filter the residual nonlinear chirp after linear compression. Pulses as short as 5.5 ps with a time bandwidth of 0.38 were obtained, a value less than half that observed without polarization dispersion filtering.
Spiroisoxazoline Synthesis via Intramolecular Cyclization/Methylation (2006)

The synthesis of regioisomeric spiroisoxazolines was achieved through an intramolecular cyclization/methylation reaction of a functionalized 5,5-disubstituted isoxazoline in one reaction vessel. The 5,5-isoxazoline was constructed through a 1,3-dipolar cycloaddition reaction of an aromatic nitrile oxide and a geminal disubstituted alkene.
A Better Characterization of Spinal Cord Damage in Multiple Sclerosis: A Diffusional Kurtosis Imaging Study (2013)

Diffusional kurtosis imaging of the spinal cord can provide a more comprehensive characterization of lesions and normal-appearing WM and gray matter damage in patients with MS. Diffusional kurtosis imaging can provide additional and complementary information to DTI on spinal cord pathology.
Targeting the “partners in crime” (2010)

In this issue of Blood, Hertlein and colleagues present compelling in vitro and in vivo evidence that the novel HSP90 inhibitor 17-DMAG is a potent and selective killer of CLL cells that mediates its effects through the targeted inhibition of NF-B. Their findings describe a promising new therapeutic approach for the treatment of this disease.
Synthesis of alpha‐Al <sub>2</sub> O <sub>3</sub> Template on Ni Superalloy Surface by Chemical Vapor Deposition (2001)

This chapter contains sections titled: Introduction Experimental Results Discussion and Conclusions Aknowledgements