gebhart/patrepeval huggingface dataset:
Preferencia de uso de la yuca, en base a las correlaciones entre composicion de la raiz, propiedades fisicoquimicas y funcionales del almidon de yuca (2009)

A group of 118 representative accessions (based on dry matter content, DMC; cyanogenic compounds, CC; amylose % and RVA functional properties) from CIAT¿s germplasm cassava collection was selected for this study. Average DMC and CC were 32% and 696 ppm, respectively. Average contents (dry basis) were: starch, 84%; fiber, 3.5%; sacarose, 3.1%; glucose and fructose 1% each, and nitrogen (N) 0.64%. Gelatinization enthalpy was 15J/g; and gelatinization temperature (TG) was 61.3°C. Average amylose content (quantified through DSC) was 20%. Swelling power, solubility and Ö evaluated through RVA at 75°C were 30.0g/g, 10.6%, and 0.7, respectively. Root DMC was correlated with starch, fiber and sugars contents. TG was strongly associated with pasting temperature (Tpasting) of the gels obtained from the RVA. Percentage of amylose correlated well with gel clarity. CC correlated with swelling power. This study allows a better understanding of the preference by processors and consumer of cassava products from "bitter" germplasm. This type of cassava is used in traditional processes in the production of healthy foods which meet the required physicochemical and sensorial characteristics.
Extensive Structural Rearrangements upon Reduction of 9<i>H</i>‐9‐Borafluorene (2014)

Abstract Common wisdom has it that organoboranes are readily oxidized. Described herein is that also their reduction can result in remarkable chemistry. Treatment of dimeric 9H‐9‐borafluorene with Li metal in toluene yields two strikingly different classes of compounds. One part of the sample reacts in a way similar to B 2 H 6 , thus affording an aryl(hydro)borane cluster reminiscent of the [B 3 H 8 ] − anion. The other part furnishes a dianionic boron‐doped graphene flake devoid of hydrogen substituents at the boron centers and featuring a central BB bond. A change in the solvent to THF allows an isolation of this dibenzo[g,p]chrysene analogue in good yields.
Thyroid and Bone: Macrophage-Derived TSH-β Splice Variant Increases Murine Osteoblastogenesis (2013)

It is now firmly established that TSH may influence the physiology and patho-physiology of bone by activating osteoblasts and inhibiting osteoclast activity resulting in relative osteoprotection. Whether this influence is directly exerted by pituitary-derived TSH in vivo is less certain, because we have previously reported that the suppression of pituitary TSH does not remove such protection. Here, we have characterized the functional relevance of a novel form of the TSH-β subunit, designated TSH-βv, known to be produced by murine bone marrow cells. We found that fresh bone marrow-derived macrophages (MØs) preferentially produced TSH-βv and, when cocultured with CHO cells engineered to overexpress the full-length TSH receptor, were able to generate the production of intracellular cAMP; a phenomenon not seen in control CHO cells, such results confirmed the bioactivity of the TSH variant. Furthermore, cocultures of MØs and osteoblasts were shown to enhance osteoblastogenesis, and this phenomenon was markedly reduced by antibody to TSH-β, suggesting direct interaction between MØs and osteoblasts as observed under the electron microscope. These data suggest a new paradigm of local modulation of bone biology by a MØ-derived TSH-like molecule and raise the question of the relative contribution of local vs pituitary-derived TSH in osteoprotection.
High incidence of antibodies to protamine and protamine/heparin complexes in patients undergoing cardiopulmonary bypass (2013)

Protamine is routinely used to reverse heparin anticoagulation during cardiopulmonary bypass (CPB). Heparin interacts with protamine to form ultralarge complexes that are immunogenic in mice. We hypothesized that patients exposed to protamine and heparin during CPB will develop antibodies (Abs) to protamine/heparin (PRT/H) complexes that are capable of platelet activation. Specimens from a recently completed prospective clinical trial (HIT [for heparin-induced thrombocytopenia] 5801 study; n = 500) of CPB patients were examined for PRT/H Abs at baseline, at time of hospital discharge (between days 3 through 7), and 30 days after CPB. PRT/H antibody features were characterized and correlated with adverse cardiovascular outcomes. We found a high incidence of PRT/H antibody formation (29%) in patients undergoing cardiac surgery. PRT/H Abs were of high titer (mean titer 1:14,744), showed heparin-dependent binding, and activated platelets in the presence of protamine. PRT/H Abs showed no cross-reactivity to platelet factor 4/heparin complexes, but were cross-reactive with protamine-containing insulin preparations. In the absence of circulating antigen at day 30, there were no complications of thrombocytopenia, thrombotic events, or long-term cardiovascular events. These studies show that Abs to PRT/H occur commonly after cardiac bypass surgery, share a number of serologic features with HIT Abs, including platelet activation, and may pose health risks to patients requiring drug reexposure.
Acoustic parameters for the automatic detection of vowel nasalization (2007)

The aim of this work was to propose Acoustic Parameters (APs) for the automatic detection of vowel nasalization based on prior knowledge of the acoustics of nasalized vowels. Nine automatically extractable APs were proposed to capture the most important acoustic correlates of vowel nasalization (extra pole-zero pairs, F1 amplitude reduction, F1 bandwidth increase and spectral flattening). The performance of these APs was tested on several databases with different sampling rates and recording conditions. Accuracies of 96.28%, 77.90% and 69.58% were obtained by using these APs on StoryDB, TIMIT and WS96/97 databases, respectively, in a Support Vector Machine classifier framework. To our knowledge these results are the best anyone has achieved on this task. Index Terms: nasal, nasalization, acoustic parameters, landmark, speech recognition.
Ocular Applications of Povidone-Iodine (2002)

Ocular infections can have devastating consequences and may lead to blindness. Povidone-iodine (PVP-I) has many potential advantages over the currently used drugs, including a broader antibacterial spectrum, it turns the surface of the eye brown for a few minutes, bacterial resistance has not been seen and it is cheaper than other agents. PVP-I has made a significant contribution to pre- and postoperative ocular surgical prophylaxis, ophthalmia neonatorum prophylaxis and treatment of bacterial conjunctivitis. Scientific support for these applications includes studies conducted over the past 17 years, which are reviewed.
Compositionally Graded Semiconductors and Their Device Applications (1986)

This paper reviews the electronic transport properties of compositionally graded materials. Band gap grading is a powerful tool for engineering the energy band diagram of a device and thus modifying its electrical transport properties (band gap engineering) (1). The most interesting property, which has far reaching consequences for devices made of these materials, is that electrons and holes experience different electric forces so the transport properties of the two types of carriers can be independently tuned.
Mosaic HIV-1 Gag Antigens Can Be Processed and Presented to Human HIV-Specific CD8+ T Cells (2011)

Polyvalent mosaic HIV immunogens offer a potential solution for generating vaccines that can elicit immune responses against genetically diverse viruses. However, it is unclear whether key T cell epitopes can be processed and presented from these synthetic Ags and recognized by epitope-specific human T cells. In this study, we tested the ability of mosaic HIV immunogens expressed by recombinant, replication-incompetent adenovirus serotype 26 vectors to process and present major HIV clade B and clade C CD8 T cell epitopes in human cells. A bivalent mosaic vaccine expressing HIV Gag sequences was used to transduce PBMCs from 12 HIV-1-infected individuals from the United States and 10 HIV-1-infected individuals from South Africa; intracellular cytokine staining, together with tetramer staining, was used to assess the ability of mosaic Gag Ags to stimulate pre-existing memory responses compared with natural clade B and C vectors. Mosaic Gag Ags expressed all eight clade B epitopes tested in 12 United States subjects and all 5 clade C epitopes tested in 10 South African subjects. Overall, the magnitude of cytokine production induced by stimulation with mosaic Ags was comparable to clade B and clade C Ags tested, but the mosaic Ags elicited greater cross-clade recognition. Additionally, mosaic Ags induced HIV-specific CD4 T cell responses. Our studies demonstrate that mosaic Ags express major clade B and clade C viral T cell epitopes in human cells, as well as support the evaluation of mosaic HIV-1 vaccines in humans.
Allogeneic stem cell transplantation for patients over age 65 with acute myelogenous leukemia and myelodysplastic syndrome. (2012)

6529 Background: ASCT represents a potentially curative approach for AML and MDS, diseases that primarily affects patients in 7 th and 8 th decade of life. Here, we report outcomes of patients older than 64 treated at the MD Anderson Cancer Center from 1996 until December 2011. Methods: 182 patients older than 64 received an ASCT for AML (n=143) or MDS (n=39). Outcomes of interest were transplant-related mortality (TRM), incidence of acute and chronic graft-versus-host disease (GVHD), incidence of relapse, and overall survival (OS) - which were estimated from the date of transplant. Results: The median age of patients was 67 (range 65-79). Most patients were transplanted with active disease (table). Median follow-up for alive patients was 12.6 months (n=63; range 0-118). The cumulative incidence of 100-day, 1 year, and 3 year TRM was 14%, 18%, and 21%, respectively. 26% of patients developed grade II-IV acute GVHD and 35% suffered from chronic GVHD. The actuarial incidence of relapse was 46% at 1 year and 53% at 3 and 5 years. Actuarial OS was estimated to be 45% at 1 year, 28% at 3 years, and 21% at 5 years. 3 year OS for patients transplanted in CR and with active disease was 40% versus 23% (p=0.02). OS of patients age 65-69 or &gt;69 was 30% vs. 20% (p=0.06) at 3 years for all patients; compared to 38% versus 27% (p=0.23) for patients in those age groups transplanted in CR. Conclusions: Although a significant minority of patients older than 64 years may achieve long-term disease control, new approaches are needed to reduce TRM and relapse in this cohort of patients. [Table: see text]
Rearrangement, hypermutation, and possible preferential use of a VH5 gene, VH32, in a Hodgkin's cell line. (1998)

Nonrandom use of immunoglobulin variable (V) gene segments is a feature of some B-cell neoplasms, possibly as a consequence of antigen selection. In Hodgkin's disease, the primary tissues, cell lines, and even single Reed-Sternberg cells can carry immunoglobulin gene rearrangements. Here, we examined the immunoglobulin heavy-chain genes of a well-characterized Hodgkin's-derived cell line, L428, and found a hypermutated VH32 gene involving a conventional V(N)D(N)J4-C gamma 4 rearrangement. VH32 is one of two rearranging members of the VH5 family that is also rearranged preferentially in some B-cell neoplasms and familial CLL. Unexpectedly, the closest known rearranged sequence match for the rearranged VH gene of L428 was found in the single Reed-Sternberg cells of lymphocyte-predominance Hodgkin's disease, and is a mutated VH251, the only other rearranging member of the VH5 family. Assuming random usage of the human VH pool, the chance of coincident VH5 family gene rearrangement in the two cases of Hodgkin's disease is only about 10(-3). Biased use of VH genes suggests a B-cell target that is either selected by antigen or vulnerable to transformation at an early antigen-independent, developmental stage. These findings raise the question whether similar processes operate in Hodgkin's disease.
Microprocessing of glass by hybrid laser processing (2002)

Hybrid laser processing for precision microfabrication of glass materials, in which the interaction of a conventional pulsed laser beam and another medium on the material surface leads to effective ablation and modification, is reviewed. The main role of the medium is to produce strong absorption of the nanosecond laser beam by the materials. Simultaneous irradiation of the vacuum ultraviolet (VUV)laser beam, which possesses extremely small laser fluence, with the ultraviolet (UV) laser greatly improves the ablation quality and modification efficiency for fused (VUV-UV multiwavelength excitation processing). Metal plasma generated by the laser beam effectively for assists high- quality ablation of transparent materials, resulting in microstructuring, cutting, color marking, printing and selective metallization of glass materials (laser-induced plasma-assisted ablation (LIPAA)). The detailed discussion described in this paper includes the ablation mechanism of hybrid laser processing.
Embolisation des Kathetertraktes nach perkutaner transhepatischer Gallenwegsintervention∗ (2000)

After embolization of fresh transhepatic tracts there were no signs of leakage during follow-up of the patients. One case with biliocutaneous fistula shows that prevention of leakage is not permanent if biliary reobstruction occurs.
Leveraging interacting signaling pathways to robustly improve the quality and yield of human pluripotent stem cell-derived hepatoblasts and hepatocytes (2022)

Pluripotent stem cell (PSC)-derived hepatocyte-like cells (HLCs) have shown great potential as an alternative to primary human hepatocytes (PHHs) for in vitro modeling. Several differentiation protocols have been described to direct PSCs toward the hepatic fate. Here, by leveraging recent knowledge of the signaling pathways involved in liver development, we describe a robust, scalable protocol that allowed us to consistently generate high-quality bipotent human hepatoblasts and HLCs from both embryonic stem cells and induced PSC (iPSCs). Although not yet fully mature, such HLCs were more similar to adult PHHs than were cells obtained with previously described protocols, showing good potential as a physiologically representative alternative to PHHs for in vitro modeling. PSC-derived hepatoblasts effectively generated with this protocol could differentiate into mature hepatocytes and cholangiocytes within syngeneic liver organoids, thus opening the way for representative human 3D in vitro modeling of liver development and pathophysiology.
Diode-grids for millimeter-wave phase-shifters and frequency doublers (2005)

Diode-grids have been fabricated on 2-cm square monolithic gallium-arsenide wafers with 1600 Schottky varactor-diodes. A computer-controlled reflectometer that uses a wave-front division interference technique was developed to measure the reflection coefficient of the diode-grids. A <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">70\deg</tex> phase shift with a 6-dB loss was obtained at 93 GHz when the bias on the diode-grid was changed from -3V to +1V. A second harmonic conversion efficiency of 16 % and an output power of 0.5 W was obtained at 66 GHz when the diode-grid was pumped with a pulsed magnetron at 33 GHz.
Broadband Digital Fourier Transform Spectrometer for On-Chip Wavelength Monitoring in the 2.3-$\mu$m Wavelength Range (2019)

We demonstrate a broadband digital Fourier Transform (dFT) spectrometer addressing wavelength monitoring applications in the 2.3-μm wavelength range. The spectrometer is built in a silicon-on-insulator platform and the design allows its fabrication with CMOS-compatible tools. We report an operating bandwidth of 130 nm around 2.3-μm wavelength using an efficient algorithm for sparse spectra to retrieve the wavelength with an accuracy of 100 pm. The spectrometer can also resolve two laser lines up for dFT spectrometers, which takes advantage of the sparse nature of the spectrum.
Comparison of prediction based LSF quantization methods using split VQ (2006)

Further improvement in performance, to achieve near transparent quality LSF quantization, is shown to be possible by using a higher order two dimensional (2-D) prediction in the coefficient domain. The prediction is performed in a closed-loop manner so that the LSF reconstruction error is the same as the quantization error of the prediction residual. We show that an optimum 2-D predictor, exploiting both inter-frame and intra-frame correlations, performs better than existing predictive methods. Computationally efficient split vector quantization technique is used to implement the proposed 2-D prediction based method. We show further improvement in performance by using weighted Euclidean distance.
Predictive current control of ac-ac modular multilevel converters (2010)

Multilevel converters can reach medium-voltage operation, increasing the efficiency in high power applications. Among the existing multilevel converter topologies, modular multilevel converter provides the advantages of high modularity, availability and high power quality. Moreover, the main advantage compared to cascaded multilevel converters is the absence of input transformer; reducing the size, cost and cooling requirements. When used as AC-AC converter, it usually requires a sophisticated controller to decouple the input and output frequency components. In this paper a predictive control approach is proposed to control a single-phase AC-AC modular multilevel converter. The controller minimizes the currents error and keeps the DC voltage balancing featuring a simple implementation, high input power factor and precise control of the output current. Moreover, the DC voltages are kept at the reference value. Simulation results showing the performance of the predictive control scheme are presented.
Digital wavelength-multiplexed holographic data storage system (1996)

We present a novel digital holographic data storage system based on wavelength multiplexing in 90 degrees geometry, using an automated tunable diode laser and a lithium niobate crystal. The automatic storage and retrieval of a 60-kbyte data file, as well as the limitations and future implementations of the system, are discussed.
Expression of a 32‐kDa ligand for the CD40 antigen on activated human T lymphocytes (1993)

To identify the ligand(s) of the human CD40 antigen, a cDNA encoding the extracellular domain of the CD40 antigen was fused to a cDNA encoding the constant region (Fc) of human IgG1. The CD40-Fc fusion protein was able to specifically bind to CD4+ and various CD8+ T cell clones activated with immobilized anti-CD3. The 125I-labeled CD40-Fc fusion protein bound anti-CD3 activated CD4+ T cell clone (MT9) with an equilibrium dissociation constant (Kd) of 10-20 nM. The human CD40-binding protein expressed on the cell surface of activated T lymphocytes is a monomeric protein of approximately 32 kDa. Minor components of 29 kDa and 17 kDa were also detected. A small proportion of CD4+ and CD8+ blood mononuclear T cells activated by anti-CD3 expressed the CD40 ligand but its detection was best observed following depletion of B cells. Addition of B cells to purified T cells abolished the binding of CD40-Fc obtained after anti-CD3 activation.
FPC-based compact 25-Gb/s optical transceiver module for optical interconnect utilizing novel high-speed FPC connector (2013)

A compact (22.6 × 9.1 × 0.86 mm), 25-Gb/s, flexible printed circuit based optical transceiver module was developed. The module consists of a 25-μm-thick FPC substrate on which a vertical-cavity surface-emitting laser array, driver, photodiode array, and a transimpedance amplifier are mounted by flip-chip bonding. The polymer waveguide is laminated from the backside of the FPC via microlens-imprinted film for the optical coupling. Its compactness and high-speed characteristics were realized by using a 0.35-mm-pitch novel FPC connector accurately designed by using a three-dimensional electromagnetic simulation. It was confirmed that the bandwidth of the FPC connector was more than 40 GHz. Also the measured results of the frequency response corresponded with the simulation results. Clear eye openings and error-free operation of all eight channels at 25 Gb/s were obtained with the fabricated optical transceiver.
Effect of in ovo feeding and its interaction with timing of first feed on glycogen reserves, muscle growth, and body weight (2011)

Chicks are commonly fasted for the first 36 to 72 h posthatch because of the logistics of commercial production. Fasting for 48 to 72 h posthatch results in retarded BW, delayed intestinal development, and lower pectoral muscle weight. This study is focused on the first 36 h of fasting and its interaction with feeding before hatch. Four treatment groups, differing in time of first feed, 6 h [early feeding (EF)] or 36 h [standard feeding procedure (SP)] posthatch, with or without in ovo feeding (IOF) with dextrin and β-hydroxy-β-methylbutyrate-calcium salt in a saline solution, were examined for glycogen status in the liver and pectoral muscle, myogenic cell proliferation, and myofiber diameter in embryos and chickens on various days posthatch. In addition, chicken BW, ADG, pectoral muscle weight, and pectoral muscle percentage of BW until 35 d of age were recorded. Results showed that delaying the first feed for 36 h posthatch (SP group) led to an irreversibly reduced growth rate compared with the EF group. However, IOF affected the growth of chickens in the SP group, whereas the control embryos had depleted glycogen reserves in the liver; IOF-treated embryos had elevated hepatic glycogen contents on embryonic day (E) 19, E20, and the day of hatch. In addition, on d 2 posthatch, although hatchlings in the SP group showed the predicted low levels of glycogen in their livers, birds in the EF group exhibited more than 30-fold and 3-fold increases in liver and muscle glycogen, respectively. In ovo-fed birds in the SP group also exhibited higher glycogen reserves, BW, pectoral muscle weight, and BW gain than control birds in the SP group. In ovo feeding had an immediate effect on promoting myoblast proliferation on E19, whereas on d 3 posthatch, the effect was pronounced only in the EF groups. On d 5, although myoblast proliferation in all groups declined, it remained higher in both IOF groups. These effects were expressed on d 3 and 35 by myofiber diameter. Together, IOF had a long-term supportive effect on BW and posthatch muscle growth when first feed was delayed by 36 h.
Survival by defense-enabling (2001)

Attack survival, which means the ability to provide some level of service despite an ongoing attack by tolerating its impact, is an important objective of security research. In this paper we present a new approach to survivability and intrusion tolerance. Our approach, which we call "survival by defense" is based on the observation that many applications can be given increased resistance to malicious attack even though the environment in which they run is untrustworthy. This paper describes the concept of "survival by defense" in general and explains the assumptions on which it depends. We will also explain the goals of survival by defense and how they can be achieved.
Abstract 19776: Angioscopic Comparison of Arterial Repair Between Biodegradable Polymer-Coated Biolimus A9-Eluting Stent and Durable Polymer-Coated Sirolimus-Eluting Stent in Patients (2010)

Background: Biodegradable polymer-coated biolimus A9-eluting stent (BES)(Terumo Corporation, Japan) are expected to show better arterial repair than first-generation DES. Thus, using angioscopy (Ve...