gebhart/patrepeval huggingface dataset:
Enabling ICN in IP networks using SDN (2013)

In this work, we outline how to enable Information-Centric Networking (ICN) on existing IP networks, such as ISP or data center networks, using Software-Defined Networking (SDN) functions and control. We describe a mechanism that requires neither new or extended network/L3 and transport/L4 protocols nor changes of ICN host network stacks, and supports aggregation of routes inside the SDN controlled network. The proposed solution is agnostic of the specific ICN protocol in use, and does not require all network elements to be SDN-enabled. It supports advanced ICN routing features like request aggregation and forking, as well as load-balancing, traffic engineering, and explicit path steering (e. g., through ICN caches). We present the design as well as our first implementation of the proposed scheme-based on the Trema OpenFlow controller-framework and CCNx.
Crop recovery of labelled -15N urinary nitrogen following simulated winter forage grazing (2015)

In Canterbury, New Zealand, sowing a spring brassica crop is a popular option for dairy cow wintering management providing feed at a time when reserves are low. However, the intensive winter forage grazing system has a high potential for nutrient loss, and gaseous and leaching losses of N increase disproportionately with stocking rate and increasing fertiliser-N use. Some studies have identified that the wintering component can represent as much as 60% of the dairy system's total annual N leaching but typically, from less than 15% of the dairy system area. Elevated nitrate concentrations in drinking water (>11.3mg NO3--N/L) may deem these unsafe for consumption by humans and livestock. Furthermore, elevated NO3--N concentrations in surface waters may cause excessive aquatic plant growth and algal blooms, causing eutrophication. Developing mitigation strategies and technologies to improve N cycle efficiency in soils is critical to minimising environmental damage, and ultimately improve the efficiency and sustainability of NZ agriculture. Winter forage grazing (WFC) systems represent a new challenge to reduce N losses from an intense event that occurs over the peak leaching period at times of minimal pasture growth. The use of a catch crop sowed following grazing and/or the application of the nitrification inhibitor, dicyandiamide (DCD), may offer a mitigation strategy and technology to reduce N leaching losses. We report the results of a field lysimeter study to measure the N balance of a winter application of labelled-15N urine (350 & 700 kg N/ha) after simulated WFG and its capture by late winter sowing of either oats (Avena sativa) or Italian ryegrass (Lolium multiflorum). We also measured the effect of a single application of DCD (20 kg/ha) on gaseous N2O and nitrate leaching losses, in particular. Results of the 15N balance for soil, plant, gases (N2O and N2) and leachate showed that leaching losses comprised about 30-34% of total-N applied in the urine and were similar for both rates of urine-N application and plant species. Applying DCD reduced N leaching loss by ~50% for the oats but less so for the ryegrass although establishment issues for the latter may have affected the result. Although leaching losses were relatively high, the late sowing of the oats and ryegrass meant significant leaching occurred prior to crop establishment. DCD application slowed the nitrification rate of the urine-N and enabled greater uptake of N by the crop when better growth conditions prevailed in the spring months.
TMPRSS2 is essential for pathogenicity of H7N9 and H1N1 influenza A viruses in mice (2014)

Influenza viruses cause an acute infection of the respiratory tract that affects millions of people during seasonal outbreaks and occasional pandemics. Furthermore, the recent outbreak of an avian H7N9 influenza virus in China, which caused severe respiratory disease and 43 deaths to date (WHO, July 4, 2013), demonstrated once again that the emergence of a novel influenza virus poses a continuous and unpredictable threat to public health.
Efficient Interference Cancellation Techniques for Advanced DS-CDMA Receivers (1999)

The focus of this dissertation is the study of advanced processing techniques for multiuser interference cancellation in direct sequence code division multiple access communications. Emphasis is placed on the development of efficient techniques that are practical to implement. The work begins with a study of several sub-optimal multiuser detection techniques under a variety of conditions. Multistage parallel interference cancellation is identified as a practical and robust approach for mitigating multiple access interference. In order to reduce the effect of biased decision statistics inherent to parallel cancellation, a low-complexity modification to parallel interference cancellation that significantly improves performance is derived. Based on this approach, two real-time DSP implementations are devised, one fully coherent and one non-coherent. Multi-symbol differential detection is then explored as an alternative for improving the performance of the non-coherent approach. Additionally, dual-antenna diversity techniques are also investigated as a means for improving performance in multipath environments.
Does the Duration of Anesthetic Administration Affect the Pharmacokinetics or Metabolism of Inhaled Anesthetics in Humans? (1987)

To define the effect of anesthetic duration on the pharmacokinetics of inhaled anesthetics, we determined the pharmacokinetics of isoflurane, enflurane, halothane, and methoxyflurane given simultaneously to seven healthy subjects for exactly 30 min and compared the results with data from a previous study in which these four anesthetics were administered for 120 min. End-tidal and mixed-expired anesthetic concentrations were measured during washin of anesthetic and for 3-9 days of washout. Multiexponential (multicompartment) models were fit by least squares to the alveolar washin and washout curves. We estimated the percentage of anesthetic that was metabolized from total uptake and recovery of anesthetic. Alveolar washout was more rapid after the shorter period of anesthetic administration. However, duration of administration did not affect the time constants determined, the number of compartments identified (i.e., five compartments were identified in both studies), or the percentages of anesthetic metabolized.
P1‐112: EFFECTS OF DEXTRAN SULFATE SODIUM‐INDUCED COLITIS ON A MOUSE MODEL OF ALZHEIMER'S DISEASE (2018)

The brain bi-directionally communicates with the gastrointestinal tract through three basic mechanisms including neuronal communication, endocrine signaling, and the immune system. The increase in blood-brain barrier permeability as well as decrease in gut epithelial barrier integrity during aging indicates the importance of understanding gut-brain axis interconnections in developing diseases. Both chronic inflammatory bowel disease (IBD including ulcerative colitis and Crohn's disease) and Alzheimer's disorder (AD) increase in prevalence among the elderly. However, the role of this intestinal inflammation on progression of AD remains unclear. We hypothesized that intestinal inflammatory changes associated with IBD may affect those within the brain. To test this idea, male C57BL/6 wild type and APPNL-G-F mice at 6-10 months of age were treated with dextran sulfate sodium (DSS), two bouts of 3 days each, to induce an IBD-like condition associated with colonic inflammation. A measurement of disease activity index (DAI) demonstrated that both strains developed a significant time-dependent DAI with chronic DSS treatment. The DAI of APPNL-G-F mice was somewhat attenuated compared to wild type controls. Vehicle control APPNL-G-F mice displayed increased locomotion and impaired working memory compared to vehicle treated wild type controls as assessed in an open field and cross maze test, respectively. Interestingly, the IBD-like condition attenuated the increased locomotion of the APPNL-G-F mice. However, the IBD-like condition had no effect on exacerbating the memory deficiency of the APPNL-G-F mice. Further biochemical and histologic assessments of intestines and brains will be required to correlate with the robust behavioral differences observed following DSS treatment. This approach validates an IBD-like model system using APPNL-G-F mice and provides a means to improve understanding of consequences of peripheral inflammatory conditions on AD progression.
Bis(2,3,4,6,7-.eta.5-bicyclo[3.2.2]nona-2,6,8-trien-4-yl)iron, a ferrocene analog with separated allyl and olefin systems (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTBis(2,3,4,6,7-.eta.5-bicyclo[3.2.2]nona-2,6,8-trien-4-yl)iron, a ferrocene analog with separated allyl and olefin systemsJanet. Bluemel, Frank H. Koehler, and Gerhard. MuellerCite this: J. Am. Chem. Soc. 1988, 110, 14, 4846–4848Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/ja00222a064https://doi.org/10.1021/ja00222a064research-articleACS PublicationsRequest reuse permissionsArticle Views79Altmetric-Citations17LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
A type system for prototyping languages (1994)

RAPIDE is a programming language framework designed for the development of large, concurrent, real-time systems by prototyping. The framework consists of a type language and default executable, specification and architecture languages, along with associated programming tools. We describe the main features of the type language, its intended use in a prototyping environment, and rationale for selected design decisions.
Combination of Haploidentical Hematopoietic with Low-Dose TBI and Cord Blood Transplantation for Hematologic Malignancies (2021)

Abstract Objective: To evaluate the efficacy and safety of the combination of haploidentical hematopoietic with low-doseTotal body irradiation（TBI）and cord blood transplantation for hematologic malignancies. Methods: This study was conducted as a retrospective review of medical records of 5 patients with hematologic malignancies who received a combination of haploidentical hematopoietic with low-dose TBI and cord blood transplantation at Affiliated HangZhou first people's hospital of Zhejiang University school of medicine, from March to June 2021. Results: 5 patients were included for the analysis. There were 1 acute myeloid leukemia (AML),2 acute lymphoblastic leukemia (ALL) and 2 Non-Hodgkin's Lymphoma(NHL). The minimal residual disease (MRD) of the two patients with ALL was positive before allo-HCT.Median age of patients at the time of allo-HCT was 30 years (range 21-63 years). All patients received low-dose TBI(4-6GY) +antithymocyte globulin（ATG）based conditioning.Cord blood units were selected based on the results of HLA typing and cell doses evaluated before freezing. Units with at least 4/6 matched HLA loci became the candidates. The median values of absolute total nucleated cell counts were 139.0 (80.8-240.0) × 10 7 / kg in The haploidentical grafts and 2.25 (1.32-3.10)× 10 7 / kg in the cord blood units,respectively. The median doses of CD34+ cells infused were 28.6 (22.0-51.1) × 10 5 / kg in the haploidentical grafts and 1.5 (1.0-3.5)×10 5/kg in the cord blood units, respectively.All patients attained complete engraftment,of which 3 were haploidentical engraftment and 2 were mixed hematopoietic chimerism that included haploidentical and cord blood engraftment.The median time to neutrophil engraftment was 12 (10-22) days and 13 (11-22) days for platelets. All patients were in complete remission with MRD-negetive during a median follow-up of 83 (34-136) days.No patients developed grade II-IV acute graft versus host desease. Conclusion:The results suggested that the combination of haploidentical hematopoietic with low-dose TBI and cord blood transplantation may potentially improve the outcome of HSCT. It offers a transplant alternative for patients with hematologic malignancies who lack matching donors. Disclosures No relevant conflicts of interest to declare.
Array projection optics: multi-channel design for ultra slim projectors (2010)

Common projection optics use a single aperture approach to create a magnified image on a screen. The transmitted flux of such systems always scales with their system dimensions thus preventing the realization of ultra compact devices along with a high lumen output. We introduce a new multi-channel approach that breaks this rule and enables the realization of ultra slim, laterally extended projection devices with high flux and integrated homogenization. Array projection optics consists of a regular two-dimensional arrangement of projective microlenses superposing their images on the screen. First we derive the scaling laws of such a multi-channel projector in contrast to common single aperture optics and analyze the system parameters of a single projection channel by Seidel aberration theory. Based on the application of these results to a variable array size the array projection optics are specified. The technological realization of a sample system with still image projection is shown and characterized with respect to modulation transfer and flux.
Automated quantitative characterisation of retinal vascular leakage and microaneurysms in ultra-widefield fluorescein angiography (2017)

Ultra-widefield fluorescein angiography (UWFA) is an emerging imaging modality used to characterise pathology in the retinal vasculature such as microaneurysms (MAs) and vascular leakage. Despite its potential value for diagnosis and disease surveillance, objective quantitative assessment of retinal pathology by UWFA is currently limited because it requires laborious manual segmentation by trained human graders. In this report, we describe a novel fully automated software platform, which segments MAs and leakage areas in native and dewarped UWFA images with retinal vascular disease. Comparison of the algorithm with human grader-generated gold standards demonstrated significant strong correlations for MA and leakage areas (intraclass correlation coefficient (ICC)=0.78-0.87 and ICC=0.70-0.86, respectively, p=2.1×10<sup>-7</sup> to 3.5×10<sup>-10</sup> and p=7.8×10<sup>-6</sup> to 1.3×10<sup>-9</sup>, respectively). These results suggest the algorithm performs similarly to human graders in MA and leakage segmentation and may be of significant utility in clinical and research settings.
Speckle Statistics for Single Fiber Endoscopy (2017)

We study the effect of speckle contrast on wavefront optimization performance in multi-mode fiber endoscopy. We compare the speckle statistics of four different multi-mode fibers and show that graded-index fibers are most suitable candidates.
Benchopt: Reproducible, efficient and collaborative optimization benchmarks (2022)

Numerical validation is at the core of machine learning research as it allows to assess the actual impact of new methods, and to confirm the agreement between theory and practice. Yet, the rapid development of the field poses several challenges: researchers are confronted with a profusion of methods to compare, limited transparency and consensus on best practices, as well as tedious re-implementation work. As a result, validation is often very partial, which can lead to wrong conclusions that slow down the progress of research. We propose Benchopt, a collaborative framework to automate, reproduce and publish optimization benchmarks in machine learning across programming languages and hardware architectures. Benchopt simplifies benchmarking for the community by providing an off-the-shelf tool for running, sharing and extending experiments. To demonstrate its broad usability, we showcase benchmarks on three standard learning tasks: $\ell_2$-regularized logistic regression, Lasso, and ResNet18 training for image classification. These benchmarks highlight key practical findings that give a more nuanced view of the state-of-the-art for these problems, showing that for practical evaluation, the devil is in the details. We hope that Benchopt will foster collaborative work in the community hence improving the reproducibility of research findings.
ASSESSING THROMBOSIS OF AN INTRAVASCULAR RESPIRATORY SUPPORT CATHETER (2002)

The Respiratory Support Catheter (RSC) is an intravenous membrane oxygenator designed to provide acute respiratory support during pulmonary failure. 10 uncoated RSC devices were evaluated with flow cytometry to measure activated platelets (aPLTs) during bovine implantation, followed by digital photography and scanning electron microscopy at explant to quantify thrombosis. 8 heparin coatings were evaluated in vitro in an attempt to improve device hemocompatibility. In vivo studies revealed that the nylon fibers used to constrain membrane fibers together in the RSC, served as a locus for thrombotic deposition. Significant deposition was observed in 9 of 10 RSCs examined, yielding 15–30% thrombus coverage of the device, in spite of systemic heparinization. aPLTs increased in blood samples collected after contact with the RSC compared to samples collected upstream. The 10th device was relatively free of deposition (∼3% coverage) with no increase in aPLTs found after device contact. In vitro tests showed heparin coating of the fiber membranes significantly reduced thrombotic deposition from 12.7% to 0.8% (n = 5, p < 0.05) after a 2 hrs blood contact. Thrombosis presents a challenge to the development of any implant-able artificial lung, including the RSC, potentially impacting device function and patient morbidity. In vivo studies determined the origin of thrombotic deposition on the RSC device, while in vitro studies revealed that heparin coated fibers may attenuate thrombosis to improve RSC biocompatibility and performance.
An Introduction to a Feedforward Demodulator (2000)

Abstract : An introduction is given to the Reconstituted FM with Feedforward (RFF) demodulator, U.S. Patent 6,002,298. This report provides the necessary background and motivation for conducting further research regarding the performance and application of this angle-demodulation technique. A comparison is made between this new technique and a standard method of angle-dernodulation by simulating a specific input signal scenario. Areas requiring further research are cited.
The effect of metformin and thiazolidinedione use on lung cancer in diabetics (2012)

The use of metformin and/or the TZDs is associated with a lower likelihood of developing lung cancer in diabetic patients. Diabetics who develop lung cancer while receiving metformin may have a more aggressive cancer phenotype.
Just Draw It! Programming by Sketching Storyboards, (1995)

Current interactive user interface construction tools make it hard for a user interface designer to illustrate the behavior of an interface. These tools focus on specifying widgets and making it easy to manipulate details such as colors, alignment, and fonts. They can show what the interface will look like, but make it hard to show what it will do, since they require programming or scripting in order to specify all but the most trivial interactions. For these reasons, most interface designers, especially those who have a background in graphic design, prefer to sketch early interface ideas on paper or on a whiteboard. We have developed an interactive tool called SILK that allows designers to quickly sketch an interface using an electronic pad and stylus. However, unlike a paper sketch, this electronic sketch is interactive. The designer can illustrate behaviors by sketching storyboards, which specify how the screen should change in response to end-user actions. This paper describes our storyboarding mechanism and provides design ideas for a production-level system.
Dendritic Cell-Based Immunotherapy in Lung Cancer (2021)

Lung cancer remains the leading cause of cancer-related death worldwide. The advent of immune checkpoint inhibitors has led to a paradigm shift in the treatment of metastatic non-small cell and small cell lung cancer. However, despite prolonged overall survival, only a minority of the patients derive clinical benefit from these treatments suggesting that the full anti-tumoral potential of the immune system is not being harnessed yet. One way to overcome this problem is to combine immune checkpoint blockade with different strategies aimed at inducing or restoring cellular immunity in a tumor-specific, robust, and durable way. Owing to their unique capacity to initiate and regulate T cell responses, dendritic cells have been extensively explored as tools for immunotherapy in many tumors, including lung cancer. In this review, we provide an update on the nearly twenty years of experience with dendritic cell-based immunotherapy in lung cancer. We summarize the main results from the early phase trials and give an overview of the future perspectives within this field.