gebhart/patrepeval huggingface dataset:
Wind waves in the North Atlantic from ship navigational radar: SeaVision development and its validation with Spotter wave buoy and WaveWatch III (2021)

Abstract. The global coverage of the observational network of the wind waves is still characterized by the significant gaps in in situ observations. At the same time wind waves play an important role into the Earth’ climate system specifically in the air-sea interaction processes and energy exchange between the ocean and the atmosphere. In this paper we present the SeaVision system for measuring wind waves’ parameters in the open ocean with navigational marine X-band radar and prime data collection from the three research cruises in the North Atlantic (2020 and 2021) and Arctic (2021). Simultaneously with SeaVision observations of the wind waves we were collecting data in the same locations and time with Spotter wave buoy and running WaveWatch III model over our domains. Measurements with SeaVision were quality controlled and validated by comparison with Spotter buoy data and WaveWatch III experiments. Observations of the wind waves with navigational Xband radar are in agreement among these three sources of data, with the best agreement for wave propagation directions. The dataset that supports this paper consists of significant wave height, wave period and wave energy frequency spectrum from both SeaVision and Spotter buoy. Currently the dataset is available through the temporary link (https://sail.ocean.ru/tilinina2021/) while supporting dataset (Tilinina et al., 2021) is in technical processing at PANGAEA repository. The dataset can be used for validation of satellite missions as well as model outputs. One of the major highlights in this study is potential of all ships navigating into the open ocean and equipped with X-band marine radar to participate into the development of another observational network for the wind waves in the open ocean once cheap and independently operating version of the SeaVision (or any other system) is available.
Structure-Property Relationships for Polycyanurate Networks Derived from Renewable Resources (2015)

The recent synthesis of a wide variety of cyanate ester monomers that may be derived from renewable resources has created a newly available set of chemical structures that, due to a wide range of chemical features, provide a unique opportunity for the development of quantitative structure-property relationships for dicyanate esters and their polymerized networks. Specific structure-property relationships for monomer melting point, glass transition temperature at full conversion, and char yields at 600 °C under nitrogen and air have been developed with the aid of partial least squares methods. The predictions inherent in these structure-property relationships are examined and compared to predictions based on ordinary least squares methods. Specific predictions for the properties of two as-yet unsynthesized dicyanate ester monomers derived from renewable resources are also presented.
Substituent-dependent asymmetric synthesis of L-threo- and L-erythro-[2,3-2H2]phenylalanine from chiral (Z)-dehydrophenylalanine (1996)

A stereo-divergent synthesis of L-threo- and L-erythro-[2,3-2H2]-phenylalanine by a catalytic deuteriation of (Z)-dehydrophenylalanine included in a chiral diketopiperazine ring is accomplished simply by changing the substituents on the nitrogen atoms in the diketopiperazine ring.
A two-class queueing model with class clustering and global FCFS service discipline (2011)

This paper considers a continuous-time queueing model with two types (classes) of customers each having their own dedicated server with exponential service times. The system adopts a "global FCFS" service discipline, i.e., all arriving customers are accommodated in one single FCFS queue, regardless of their types. "Class clustering" ,i.e., customers of any given type may (or may not) have a tendency to "arrive back-to-back", is a concept that we believe is often neglected in literature, but as it is clear that customers of different types hinder each other more as they tend to arrive in the system more clustered according to class in our system, the major aim of this paper is to estimate the impact of the degree of class clustering in our system. The motivation of our work are systems where this kind of blocking is encountered, such as input-queueing network switches or road splits.
P2‐336: Bis‐styrylpyridine and bis‐styrylbenzene derivatives as inhibitors for beta‐amyloid fibril formation (2008)

Since cholinergic deficit in the central nervous system has been observed in AD patients, inhibitors for acetylcholine esterase (AchE) such as tacrin, donepezil, and rivastigmine are used for the clinical treatment of AD symptoms in current therapeutic approaches. Although these are the only FDA-approved AD therapies on the market, they cannot solve fundamental problems but can be only palliative solutions. Pathomorphologically important hallmarks in AD are senile plaques (SP) composed of amyloid β (Aβ) and neurofibrillary tangles (NFTs). Therefore, reducing deposition of Aβ plaques in the brain is believed to be pivotal to treat the AD patients. Based on Aβ hypothesis, Aβ(1–42) monomers released from APP by β- and γ-secretases are gradually aggregated to oligomers, protofibrils, and fibrils. Aβ(1–42) aggregates such as oligomers and fibrils deposit in the brain causing strong neuronal toxicity. In addition, it was recently reported that oligomers might be more toxic than fibrils, and the oligomers are becoming the target for the development of AD treatments. Here we report the synthesis and evaluation of novel bis-styrylpyridine and bis-styrylbenzene derivatives as Aβ aggregation inhibitors. The 34 compounds were evaluated by Aβ fibril formation inhibitory assay using thioflavin T. Most of the synthesized compounds in this study inhibited Aβ(1–42) fibril formation near sub-μM range of IC50 (0.1–2.7 μM), better than curcumin (0.8 μM), without cytotoxicities on HT-22 neuronal cells by MTT assay at 1, 10, and 50 μM. In particular, KMS80013, KMS80019, KMS80029, and KMS80030 exhibited the best data of inhibition activities and cytotoxicities and are promising AD drug candidates.
Exploring plenoptic properties of correlated light (2018)

Imaging aims to create a correspondence between the distribution of light in an object plane, in which the objects of interest are placed, and in an image plane, where a sensor measures intensity. An imaging device is characterized by resolution, which determines how sharp is the correspondence between the two conjugate planes, and depth of field, which fixes the longitudinal distance range in which the object can move, while its image is still well focused on the sensor. Unfortunately, a natural tradeoff between resolution and depth of field entails that focusing a high-resolution image is much harder than focusing a low-resolution one. Moreover, standard imaging devices are not able to recover information on the out-of-focus planes after the acquisition. The goal of plenoptic imaging is to overcome this limitation, by retrieving combined information on both the spatial distribution and the direction of light in the scene of interest, which opens the possibility to refocus planes of the scene in a much wider range than the natural depth of field of the system, and also to change the point of view on the scene. Though plenoptic imaging is one of the most promising techniques for 3D imaging, in all the devices based on intensity measurements its advantages come at the expense of spatial resolution, which can no longer reach its diffraction limit. In this paper, we review the possibility to avoid loss of resolution by integrating second-order intensity correlation measurements in a simple single-lens imaging setup. The described device, based on the correlation plenoptic imaging (CPI) technique, enables one to perform either standard or plenoptic imaging, while keeping the resolution at the diffraction limit. We show that the proposed setup outperforms both standard imaging and first-order plenoptic imaging in terms of resolution and depth of field.
Identification of Pre-Catastrophic Failure Mechanisms in High Power GaN HEMT (2011)

The research describes an investigation into an observed phenomenon believed to be correlated with catastrophic device failure cause by the breakdown in the gate structure in high power, high frequency GaN HEMTs. Several devices that were stressed on an elevated temperature extended reliability test station showed significant changes in gate current prior to catastrophic failure. In an effort to electrically examine the devices during the breakdown process, similar devices were stressed on wafer. Detailed measurements were performed on the devices at regular intervals. On several devices, the behavior of interest was reproduced. Of the periodic measurements performed, a gate current sweep provided the greatest insight into device operation. Explanations for the observed phenomena are discussed.
Using Bioprinting to Tissue Engineer Microvascularized Constructs for Skeletal Muscle Repair (2019)

Introduction One challenge in tissue engineering (TE) is designing a construct which ensures adequate oxygen diffusion and removal of waste throughout the implanted tissue. In native tissue, the maximum distance between any cell and capillary is limited to the diffusion distance of oxygen, or 100–200 μm1. Mimicking this dense microvasculature in TE constructs is critical to cell viability and function, particularly in thick implants, such as those for skeletal muscle repair2. There have been many recent advancements in using TE to develop skeletal muscle constructs for the treatment of volumetric muscle loss (VML) in injuries incurred by soldiers and civilians. We have developed a tissue engineered muscle repair (TEMR) technology which consists of myoblasts seeded onto a porcine bladder acellular matrix (BAM). While TEMR has previously been reported to result in 60–70% functional recovery in rodent models within 2 months after implantation3,4, we hypothesize that incorporating endothelial cells (ECs) and pericytes in the TEMR will accelerate the rate and magnitude of functional recovery by facilitating anastomosis with the recipient microcirculation and increasing perfusion into the construct. Objective Use bioprinting to position endothelial cells and pericytes with myoblasts on the BAM to “pre‐vascularize” the TEMR construct. Results Decellularized microvasculature basement membrane remains intact in some areas of the BAM (Figure 1A). Using the Organovo NovoGen Bioprinter ® , we have developed a novel bioprinting method to pattern ECs and myoblasts on the acellular bladder matrix (BAM). ECs seeded onto the BAM begin to form network‐like structures after just 24 hours (Figure 1B). EC viability was shown to be high (&gt;90%) for two bioprinting needle diameters (250 μm vs 500 μm). (Figure 1C). Conclusions The presence of ECM from microvasculature on the BAM suggests that the BAM is a promising scaffold for pre‐vascularization. This is further supported by the formation of endothelial network‐like formations on the BAM after just 24 hrs. It is also encouraging that the 250 μm bioprinting needle does not reduce cell viability, as a smaller diameter allows for more precise patterning of cells. Together, these preliminary results suggest that it is feasible to “pre‐vascularize” the TEMR construct by bioprinting. Future Work We will further investigate EC viability and network formation in co‐culture with myoblasts. We also plan to incorporate bioprinted pericytes to further encourage and support the formation of pre‐vascularized microvascular networks in TEMR. Support or Funding Information NIH T32 GM008715, Organovo, Inc., and the UVA Center for Advanced Biomanufacturing This abstract is from the Experimental Biology 2019 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Joint workshop on the economics of networked systems and incentive-based computing (2007)

No abstract available.
Advanced Rate Adaption for Unicast Streaming of Scalable Video (2010)

Recent advances in scalable video coding have paved the way for the development of flexible and adaptive media streaming applications. In order to support rate adaptation, 3GPP Packet-Switched Streaming Service (PSS) has specified a feedback mechanism that includes transmitting information about the status of the client buffer. This paper presents a novel Multiple Virtual Client Buffer Feedback (MVCBF) mechanism, which includes information about multiple media times each of which corresponding to a different set of sub-streams in scalable media streaming. Moreover, a new rate adaptation method is presented that a) assigns different requirements for the buffering time to the different sets of sub-streams, b) observes the media time variation at sub-stream level, and c) efficiently changes the operation point to maintain the required buffering time in priority order. Simulation results show that the proposed MVCBF-based rate adaptation algorithm outperforms the traditional PSS compliant rate adaptation method in the overall throughput by quickly adapting the operation point to the varying network resources and avoiding unnecessary bouncing between operation points.
Pathogenic roles of Toll‐like receptor 2 and intracellular bacteria in intimal hyperplasia in apolipoprotein E‐deficient mice (2008)

Atherosclerosis is an inflammatory disease, and recent evidence suggests that innate immunity may contribute to the inflammatory process. We recently found that vascular smooth muscle cells (VSMC) express Toll‐like receptor 2 (TLR2) and TLR4, and that activating TLR2 or TLR4 in VSMC induces marked phenotypic changes, including increased proliferation. Here we assessed the role of TLR2 in spontaneous and in injury‐ and bacteria‐induced intima formation in apolipoprotein E‐deficient mice. Mice having deficiencies of both ApoE and TLR2 (double knockout; DKO) were generated by cross‐breeding mice bearing single knockouts of each gene. Wire‐induced denudation injury elicited intima formation in ApoE KO mice, and this effect was inhibited by 37% in ApoE/TLR2 DKO mice (0.038±0.014 vs. 0.024±0.012 mm 2 , n=4). TLR2 deficiency also reduced spontaneous lesion formation in the lesser curvature of the aortic arch by 54% (12.1±2.2% vs. 5.6±0.9%; n=8). In addition, exposing the carotid arterial adventitia of ApoE KO mice in vivo to Chlamydia pneumoniae , an atherosclerosis‐associated intracellular bacterium that activates VSMC via TLR2 and TLR4 signaling, elicited similar intima formation in ApoE KO mice. The results reveal that TLR2 signaling may participate in injury‐induced intima formation, and establish a hypercholesterolemic mouse model of bacteria‐induced arterial pathogenesis. Supported by NIH HL47569.
Memory-map selection for firm real-time SDRAM controllers (2012)

A modern real-time embedded system must support multiple concurrently running applications. To reduce costs, critical SoC components like SDRAM memories are often shared between applications with a variety of firm real-time requirements. To guarantee that the system works as intended, the memory controller must be configured such that all the real-time requirements of all sharing applications are satisfied. The attainable worst-case bandwidth, latency, and power of the memory depend largely on memory map configuration. Sharing SDRAM amongst multiple applications is challenging, since their requirements might call for different memory maps. This paper presents an exploration of the memory-map design space. Two contributions improve the memory-map selection procedure. The first contribution reduces the minimum access granularity by interleaving requests over a configurable number of banks instead of all banks. This technique is beneficial for worst-case performance in terms of bandwidth, latency and power. As a second contribution, we present a methodology to derive a memory-map configuration, i.e. the access granularity and number of interleaved banks, from a specification of the real-time application requirements and an overall memory power budget.
New ephemerellidae from Spain (ephemeroptera) (1983)

Abstract The nymphal descriptions of four species of Ephemerellidae from Spain are given. The genera Serratella Edmunds and Drunella Needham are cited for the first time in the Paleartic Region. The paper includes a key to the Iberian Ephemerellidae species.
Uttalelse om Bayer CropScience genmodifiserte rislinjen LibertyLink(LLRICE62)(EFSA/GMO/UK/2004/04). Vurdert og godkjent av Faggruppe for genmodifiserte organismer (2005)

SAMMENDRAGDenne uttalelsen er utfrt av Faggruppen for genmodifiserte organismer under Vitenskapskomiteen for mattrygghet.Faggruppen baserer sin vurdering av Bayers genmodifiserte herbicidtolerante rislinjen LibertyLink (LLRICE62) p den dokumentasjonen som er gjort tilgjengelig p EFSAs nettside GMO EFSAnet
A flexible in-vehicle HMI architecture based on web technologies (2010)

In this paper, we describe a flexible in-vehicle Human-Machine-Interface (HMI) that is based on a service-oriented architecture (SOA) enriched by graphical information. Our approach takes advantage of standard web technologies and targets at a solution that can be flexibly deployed in various application scenarios as, e.g., for in-vehicle driver-assistance systems, in-flight entertainment systems or generally spoken, systems which allow multiple persons to interact with an HMI. Furthermore, we consider the integration of consumer electronic devices. The proposed system benefits from its SOA-driven, generic approach and comes along with advantages like platform-independency, scalability, faster time to market and lower price compared to application-specific approaches.
Transformation of Castleman's Disease into Follicular Dendritic Cell Sarcoma, Presenting as an Asymptomatic Intra-abdominal Mass (2013)

Follicular dendritic cell (FDC) sarcoma is an extremely rare malignant neoplasm arising from FDCs. The exact origin of FDCs remains unclear; both a hematopoietic lineage origin and a stromal cell derivation have been proposed. Proliferation of FDCs can lead to benign reactive lesions or generate neoplastic conditions. The lesions are most commonly found in lymph nodes and usually involve the head and neck area. Castleman's disease is a rare non-neoplasitic lymphoproliferative disorder. Rare cases of hyaline-vascular Castleman's disease have been associated with FDC sarcoma, but a clonal relationship has not been convincingly demonstrated. A pathway toward tumor evolution, beginning with hyperplasia and dysplasia of FDCs, has been proposed. Despite this known association between Castleman's disease and FDC sarcoma, there have only been few reported cases of sarcoma arising as a complication of pre-existing Castleman's disease, especially in abdominal lesions. We describe here a 51-year-old female with an FDC sarcoma arising from unicentric, hyaline-vascular type Castleman's disease in an intra-abdominal mass. Pathologically, the lesion showed a series of changes during the process of transformation from Castleman's disease to FDC sarcoma. (Korean J Gastroenterol 2013;62:131-134).
Reaction of gem-dichloroallyllithium with aldehydes, ketones, and other organic substrates. An example of electronic control of regioselectivity in the reactions of an ambident nucleophile (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of gem-dichloroallyllithium with aldehydes, ketones, and other organic substrates. An example of electronic control of regioselectivity in the reactions of an ambident nucleophileDietmar Seyferth, Gerald J. Murphy, and Bernard MauzeCite this: J. Am. Chem. Soc. 1977, 99, 16, 5317–5330Publication Date (Print):August 1, 1977Publication History Published online1 May 2002Published inissue 1 August 1977https://pubs.acs.org/doi/10.1021/ja00458a016https://doi.org/10.1021/ja00458a016research-articleACS PublicationsRequest reuse permissionsArticle Views224Altmetric-Citations73LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Wide-field interferometric phase microscopy with molecular specificity using plasmonic nanoparticles (2013)

We present a method for adding molecular specificity to wide-field interferometric phase microscopy (IPM) by recording the phase signatures of gold nanoparticles (AuNPs) labeling targets of interest in biological cells. The AuNPs are excited by time-modulated light at a wavelength corresponding to their absorption spectral peak, evoking a photothermal (PT) effect due to their plasmonic resonance. This effect induces a local temperature rise, resulting in local refractive index and phase changes that can be detected optically. Using a wide-field interferometric phase microscope, we acquired an image sequence of the AuNP sample phase profile without requiring lateral scanning, and analyzed the time-dependent profile of the entire field of view using a Fourier analysis, creating a map of the locations of AuNPs in the sample. The system can image a wide-field PT phase signal from a cluster containing down to 16 isolated AuNPs. AuNPs are then conjugated to epidermal growth factor receptor (EGFR) antibodies and inserted to an EGFR-overexpressing cancer cell culture, which is imaged using IPM and verified by confocal microscopy. To the best of our knowledge, this is the first time wide-field interferometric PT imaging is performed at the subcellular level without the need for total internal reflection effects or scanning.
Lessons Learned Designing a Spherical Satellite Release Mechanism (2008)

A low-cost mechanism, part of the CAPE ICU payload, was designed to contain and deploy two spherical satellites from the Shuttle in December 2006. Overall the system successfully placed the satellites into orbit but encountered an anomaly. This flight anomaly and subsequent investigation revealed several key design issues. This paper discusses the lessons learned from the inaugural mission.
Structure and Mechanism in Cinchona Alkaloid Chemistry: Overturning a 50-Year-Old Misconception (1999)

Long-standing errors of the supposedly established literature, including textbooks and data bases have been corrected: The structure of the hetero-cinchona bases in the crystal and in solution (see scheme) and the mechanism of their formation from quinine and quinidine have been elucidated.
Ceragenin-Coated Non-Spherical Gold Nanoparticles as Novel Candidacidal Agents (2021)

The results provide rationale for the development of gold nanoparticles of rod-, peanut-, and star-shaped conjugated with CSA-13, CSA-44, and CSA-131 as effective candidacidal agents.
Ganglion cell-inner plexiform layer and retinal nerve fiber layer thickness according to myopia and optic disc area: a quantitative and three-dimensional analysis (2017)

Myopia can significantly affect GCIPL and RNFL thickness profiles, and optic disc size has a significant influence on RNFL thickness. The current OCT maps employed in the evaluation of glaucoma should be analyzed in consideration of refractive status and optic disc size.