gebhart/patrepeval huggingface dataset:
The antimicrobial properties of Pd(II)- and Ru(II)-pyta complexes (2023)

Infections associated with antimicrobial resistance (AMR) are poised to become the leading cause of death in the next few decades, a scenario that can be ascribed to two phenomena: antibiotic over-prescription and a lack of antibiotic drug development. The crowd-sourced initiative CO-ADD has been testing research compounds contributed by researchers around the world to find new antimicrobials to combat AMR, and during this campaign has found that metallodrugs might be a promising, yet untapped source. To this end, we submitted 18 Pd(II) and Ru(II) – pyridyl-1,2,3-triazolyl complexes which were developed as catalysts for their antimicrobial properties. It was found that the Pd-complexes possessed potent antifungal activity, especially Pd1, with MICs between 0.06 – 0.125 µg/mL against C. glabrata. The in vitro studies were extended to in vivo studies in G. mellonella larvae where it was established that the compounds were non-toxic. Here we effectively demonstrate the potential of Pd(II)-pyta complexes as antifungal agents.
Oldest packet drop (OPD): A buffering mechanism for beaconing in IEEE 802.11p VANETs (poster) (2011)

The IEEE 802.11p MAC technology can be used to provide connectivity for real-time vehicle control known as Cooperative Adaptive Cruise Control. Due to the real-time nature of this system, it is paramount the delay of the received information is as small as possible. This paper researches the Oldest Packet Drop buffering mechanism to increase freshness of beacons compared to the standard EDCA transmission queues, which have a tail-drop policy. We find that using the Oldest Packet Drop buffering mechanism instead of the standard tail-drop can significantly improve the freshness of the received beacons by reducing the queueing delay experienced by the beacons under near-saturation conditions.
Living cationic isomerization polymerization of ?-pinene. III. Synthesis of end-functionalized polymers and graft copolymers (1997)

α-End-functionalized polymers and macromonomers of β-pinene were synthesized by living cationic isomerization polymerization in CH2Cl2 at −40°C initiated with the HCl adducts [1; CH3CH(OCH2CH2X)Cl; X = chloride (1a), acetate (1b), and methacrylate (1c)] of vinyl ethers carrying pendant substituents X that serve as terminal functionalities. In conjunction with TiCl3(OiPr) and nBu4NCl, these functionalized initiators led to living β-pinene polymerization where the carbon–chlorine bond of 1 was activated by TiCl3(OiPr). Similarly, end-functionalized poly(p-methylstyrene)-block-poly(β-pinene) were also obtained. 1H-NMR analysis showed that the polymers possess controlled molecular weights (DPn = [M]0/[1]0) and number-average end functionalities close to unity. The end-functionalized methacrylate-capped macromonomers form 1c were radically copolymerized with methyl methacrylate (MMA) to give graft copolymers carrying poly(β-pinene) or poly(p-methylstyrene)-block-poly(β-pinene) as graft chains attached to a PMMA backbone. © 1997 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 35: 1423–1430, 1997
Mechanisms regulating the peripheral utilisation of glucose: involvement of AMPK (2010)

International audience
Rotational assignment using phase relationships in optical–optical double resonance: The BaI <i>C</i> 2Π–<i>X</i> 2Σ+ system (1985)

We describe an optical–optical double resonance scheme in which a lower vibration-rotation level is labeled. One laser is fixed in frequency and probes the population of the labeled level via the resulting laser-induced fluorescence; a second laser is scanned in frequency through the same vibronic band excited by the probe. A double resonance signal results when the population in the labeled level is either increased or decreased by the action of the second laser. The positions and phase pattern of the double resonance spectrum reveal the J numbering of the labeled level and permit a good approximation to be made for the upper and lower state rotational constants. This information allows the J value of the labeled level to be systematically changed, permitting the spectrum to be unraveled. This technique is proven by applying it to the highly congested C–X spectrum of the BaI molecule, for which no rotational information was previously available for any of its states.
Metal-supported palladium membranes for hydrogen separation (2015)

The demand for clean and green energy has raised the consumption of hydrogen continuously during the last years. Hydrogen is most economically produced in large scale systems by methane steam reforming followed by pressure swing adsorption (PSA). However, with a rising demand for small-scale production of hydrogen, and as down-scaling to smaller PSA-systems ( < 500 Nm3/h H2) is not economic, a substantial demand for hydrogen generation using palladium membranes has emerged.Porous tubes made of an oxide dispersion strengthened powder metallurgy Fe-Cr alloy (trade name ITM) constitute the backbone for the thin solid Pd films. The tubes provide mechanical and chemical long-term stability in atmospheres with hydrogen- and carbon-species at operation temperatures up to 600°C. A porous ceramic diffusion barrier layer (DBL) is deposited between the ITM-backbone and the Pd thin-film to avoid Pd diffusion into the Fe-Cr substrate and thereby ensure long-term integrity of the system. The Pd thin-film with a thickness < 10 μm is applied onto the DBL by a proprietary coating technology.This paper describes the production route of a tube/diffusion-barrier-layer/Pd-membrane system, its structure and permeation properties.
A partnership approach to research data management (2013)

This outlines developments to support and enhance research data management policy and practice at the University of Southampton. It details a research-led approach to identify institutional challenges and priorities and use of this evidence-base to inform the creation of a 10 year roadmap and policy framework. The particular issues relating to workflow, storage, security and archiving are discussed and examples are given of both pilot and embedded services including data management planning support, postgraduate training and data repository facilities.
Die minimal-invasive Cochlea-Implantat-Chirurgie : Der lange Weg von der Forschung in die klinische Routine (2020)

Der Einsatz eines Cochlea- Implantats bei tauben oder schwerhörigen Patienten ist bis heute nur durch eine Operation möglich, bei der eine 2 bis 3 cm tiefe Öffnung in den Schädel-knochen gefräst werden muss. Seit langer Zeit bemühen sich Wissenschaftlerinnen und Wissenschaftler Technologien zu entwickeln, um diesen Vorgang minimal-invasiv vornehmen zu können. Dr.-Ing. Thomas Rau von der Medizinischen Hochschule Hannover und Prof. Dr. Tobias Ortmaier vom Institut für Mechatronische Systeme beschreiben die gemeinsamen, interdisziplinären Forschungs-ansätze an beiden Einrichtungen.
Two-phase thermal management using a small-scale, heat transfer cell based on vibration-induced droplet atomization (2004)

A two-phase heat transfer module in which thin-film evaporation on the hot surface is achieved using surface droplet atomization is described and characterized. Surface atomization is achieved using a vibration-induced droplet atomization (VIDA) process in which small liquid droplets are produced within a sealed heat transfer cell and are propelled onto the heated surface. The VIDA technique involves the violent break-up of thin liquid layers on the vibrating surface of a piezoelectrically driven membrane that is operated at resonance. Liquid is supplied to the atomizer at a controlled rate using an integrated miniature piezoelectric pump thereby enabling orientation insensitive cell operation. The impact of the atomized droplets on the heated surface forms a thin film that evaporates continuously and the resulting vapor is condensed both on the internal surfaces of the heat transfer cell and on the surface of the atomized droplets. The condensate is collected and returned to the atomizer module by the integral diaphragm pump. The present paper describes the operation and characterization of a small-scale VIDA heat transfer module for cooling integrated circuits at the power level of desktop microprocessors. A unique element of the new cell is the addition of an internal synthetic jet that operates in the vapor space and regulates the droplet motion towards the heated surface and the transport of the vapor. Particular emphasis is placed on the cell's operating characteristics and cooling capabilities. Heat fluxes as high as 420 W/cm/sup 2/ have been realized at die temperature below 135/spl deg/C.
Hereditary heparin cofactor II deficiency and thrombosis (1990)

We describe six patients belonging to two families with congenital heparin cofactor II deficiency (HC II). The affected members had low levels of HC II antigen and activity, and no abnormalities in HC II electrophoretic mobility were detected in the presence of heparin or dermatan sulphate during the first migration of crossed immunoelectrophoresis. These data suggested that patients had a type I (true) HC II deficiency. The association of thrombotic manifestations with congenital HC II deficiency has not been completely clarified. In these two families, thrombotic events occurred in two out of six affected members. In addition, there was a high incidence of spontaneous abortion in the affected females. Finally, the association of congenital HC II deficiency with angiomatosis was also observed in one patient.
Génération de supercontinuum dans une fibre optique monomode standard en régime de dispersion normale par cascade Raman (2017)

International audience
Mechanical properties of RF-sputtering MoS<sub>2</sub>thin films (2017)

We present an evaluation of the hardness and Young's modulus properties of medium pressure sputtered molybdenum disulfide (MoS2) thin films by applying nano-indentation with continuous stiffness method combined with microstructure analysis using small angle x-ray diffraction, Raman, and an electron microscope in scanning and transmission mode. Our results indicate a vertical growth of MoS2 crystallites with stacking values of 7-laminates along the [0 0 1] direction and an average height of 105 nm, principal Raman vibrations at at 378 cm−1 and A1g at 407 cm−1 and an interplanar distance of ~0.62 nm as confirmed by high-resolution transmission electron microscopy. An average hardness of H = 10.5 ± 0.1 GPa and elastic modulus of E = 136 ± 2 GPa from 0 to 90 nm of indenter penetration were found in these investigations.
High-level soccer indexing on low-level feature space (2005)

In this paper, we propose an efficient scene clustering algorithm for soccer videos. Such scene clustering in sports videos is one of the semantic indexing techniques that can he applied to editing, summarizing, and content structuring. Our proposed method exploits a small set of audio and visual low level features that can be easily extrdcted from an MPEG compressed video, and classifies a soccer video into five predefined scene classes, from lower importance to higher importance. Based on very simple determination criteria, simulation results have shown that our method successfully performs semantic indexing for soccer videos at low computational cost.
The quest for affinity chromatography ligands: are the molecular libraries the right source? (2015)

Affinity chromatography separations of proteins call for highly specific ligands. Antibodies are the most obvious approach; however, except for specific situations, technical and economic reasons are arguments against this choice especially for preparative purposes. With this in mind, the rationale is to select the most appropriate ligands from collections of pre-established molecules. To reach the objective of having a large structural coverage, combinatorial libraries have been proposed. These are classified according to their nature and origin. This review presents and discusses the most common affinity ligand libraries along with the most appropriate screening methods for the identification of the right affinity chromatography selective structure according to the type of library; a side-by-side comparison is also presented.
Exposição de ciclistas ao ruído em uma cidade média brasileira (2020)

This study aimed to assess cyclists' exposure to noise in a medium-sized Brazilian city. Mobile sensors were used to conduct noise measurements in streets with and without dedicated cycling infrastructures. The method can be summarized in the following procedures: i) characterization of the study area; ii) data collection and validation; iii) calculation of exposure indicators; and iv) comparison and representation of the results on maps. Two strategies were adopted for the analysis, namely, spatial data aggregation and temporal data aggregation. Thus, measurements were initially organized in 1,200 nodes distributed along the paths. The results indicate that bicycle riders in São Carlos may be exposed, in some routes, to a high proportion of high noise-level segments. In the two routes selected for this study, the cyclist was exposed to noise levels above the adopted threshold (> 75dBA) in 33.2% and 18.9% of the nodes. Also, the possibility of simultaneously working with two related indicators has broadened the classification criteria of the route segments regarding noise exposure.
1-[2,2-Bis(phenylsulfonyl)ethenyl]-4-methoxybenzene (2012)

In the title compound, C(21)H(18)O(5)S(2), the two sulfur-bound phenyl rings lie on opposite sides of the meth-oxy-phenyl group, making dihedral angles of 77.58 (8) and 87.45 (8)°with it. The dihedral angle between the sulfur-bound phenyl rings is 57.31 (8)°. In the crystal, π-π stacking is observed between the two sulfur-bound phenyl rings, with a centroid-centroid distance of 3.878 (1) Å and a dihedral angle of 7.58 (8)°. The mol-ecules are linked by weak C-H⋯O and C-H⋯π contacts.
(Sample) Size Matters! An Examination of Sample Size From the SPRINT Trial Study to Prospectively Evaluate Reamed Intramedullary Nails in Patients With Tibial Fractures (2012)

Our findings highlight the risk of conducting a trial with insufficient sample size and power. Such studies are not only at risk of missing true effects but also of giving misleading results.
&lt;title&gt;Early demonstration of remotely queried microsensors&lt;/title&gt; (1999)

Prototype remotely queried embedded microsensor devices were installed on two US Navy platforms to verify the robustness of the transponder circuitry to survive in operational environments. Devices were installed on the Advanced Enclosed Mast/Sensor System aboard USS Radford in May 1998. These devices are in the high EMI environment of the SPS-40 radome. The devices were checked after deployment in October and were functioning normally. Devices were also installed on the Boeing AV-8B Harrier T1 aircraft and have successfully survived the vibration, temperature and acoustic noise environment of flight operations. These devices remain installed on these platforms and will be periodically checked to determine the suitability of the transponder circuitry for long term operation.
On Information Bottleneck for Gaussian Processes (2022)

The information bottleneck problem (IB) of jointly stationary Gaussian sources is considered. A water-filling solution for the IB rate is given in terms of its SNR spectrum and whose rate is attained via frequency domain test-channel realization. A time-domain realization of the IB rate, based on linear prediction, is also proposed, which lends itself to an efficient implementation of the corresponding remote source-coding problem. A compound version of the problem is addressed, in which the joint distribution of the source is not precisely specified but rather in terms of a lower bound on the guaranteed mutual information. It is proved that a white SNR spectrum is optimal for this setting.
Is UO2 irradiation resistance due to its high temperature behaviour? (2011)

International audience
Safety/tolerability of the anti-semaphorin 4D antibody VX15/2503 in a randomized phase 1 trial (2017)

This study provides Class III evidence that anti-semaphorin 4D antibody VX15/2503 at various doses was safe and well tolerated vs placebo, although an increase in treatment-emergent adverse events in the treatment group could not be excluded (risk difference -0.7%, 95% CI -28.0% to 32.7%).
Modeling HNF1B-associated monogenic diabetes using human iPSCs reveals an early stage impairment of the pancreatic developmental program (2021)

Heterozygous mutations in HNF1B in humans result in a multisystem disorder, including pancreatic hypoplasia and diabetes mellitus. Here we used a well-controlled human induced pluripotent stem cell pancreatic differentiation model to elucidate the molecular mechanisms underlying HNF1B-associated diabetes. Our results show that lack of HNF1B blocks specification of pancreatic fate from the foregut progenitor (FP) stage, but HNF1B haploinsufficiency allows differentiation of multipotent pancreatic progenitor cells (MPCs) and insulin-secreting β-like cells. We show that HNF1B haploinsufficiency impairs cell proliferation in FPs and MPCs. This could be attributed to impaired induction of key pancreatic developmental genes, including SOX11, ROBO2, and additional TEAD1 target genes whose function is associated with MPC self-renewal. In this work we uncover an exhaustive list of potential HNF1B gene targets during human pancreas organogenesis whose downregulation might underlie HNF1B-associated diabetes onset in humans, thus providing an important resource to understand the pathogenesis of this disease.
Differential activation of renal sympathetic burst amplitude and frequency during hypoxia, stress and baroreflexes with chronic angiotensin treatment (2015)

What is the central question of this study? Is the elevated tonic renal nerve activity induced by chronic angiotensin administration mediated by recruitment or increased firing frequency and does this occur via stress, chemoreflex or baroreflex pathways? What is the main finding and its importance? Long-term angiotensin treatment in rabbits elevates renal sympathetic nerve activity by recruitment of previously silent fibres. This was similar to the effect of chemoreflex stimulation, but not to stress or baroreceptor activation, suggesting that presympathetic pathways activated by angiotensin may be common to those activated by chemoreceptors. Modulation of sympathetic nerve activity involves control by the CNS of the amplitude of neural discharges, reflecting recruitment of neurons and their firing frequency. We tested whether elevated tonic renal sympathetic nerve activity (RSNA) induced by chronic angiotensin administration is mediated by recruitment or increased firing frequency and whether this is characteristic of the pattern observed with activation of stress, chemoreflex or baroreflex pathways. Conscious rabbits treated with angiotensin II for 12 weeks to increase blood pressure by 10-30% were subjected to stress (air jet), hypoxia (10% O2 + 3% CO2) and drug-induced changes in blood pressure to produce baroreflexes. Total RSNA and RSNA burst amplitude were scaled to 100 normalized units (n.u.) by the maximal response to smoke. After 12 weeks of treatment, blood pressure was 17% higher than baseline 68 ± 1 mmHg (P = 0.02). Compared with sham treatment, total RSNA and burst amplitude were +82% (P < 0.001) and 39% (P = 0.04) greater, but burst frequency was similar. Total RSNA increased during hypoxia (+38% from 4.9 ± 0.7 n.u.), owing to greater amplitude, but not frequency. Air-jet stress increased total RSNA (+44% from 4.3 ± 0.5 n.u.) and burst frequency (+21% from 5.4 ± 0.7 bursts s(-1) ), but not amplitude. Angiotensin enhanced total RSNA responses to both air jet (+33%) and hypoxia (+58%), but only increased the amplitude response to air jet. The RSNA baroreflexes reset to the higher blood pressure, but amplitude or frequency was not differentially altered. Chronic angiotensin treatment elevated RSNA by recruitment of neurons, which is similar to chemoreflex stimulation, but not to stress or baroreceptor activation, suggesting that presympathetic pathways activated by angiotensin may be common to those activated by chemoreceptors.
Phénotypage métabolique du miniporc: une base à des applications en nutrition humaine (2013)

Une des applications les plus novatrices des approches métabolomiques est l’analyse \ncinétique, sur un même individu, des changements du métabolome (trajectoire \nmétabolomique) lors de l’adaptation du métabolisme à une altération du régime. L’objet \ndu présent travail est de valider la possibilité d’une approche de ce type à l’échelle de la \njournée, en utilisant un modèle de mini porc cathétérisé permettant des suivis \nlongitudinaux. Trois miniporcs Gottingen ont été nourris avec un repas test et des \néchantillons de sang ont été prélevés à jeun puis 1, 2, 3 et 4h après le repas à l’aide \nd’un cathéter artériel. Nous avons mesuré les taux circulants de glucose, insuline, \ntriglycérides, lactate et urée ainsi que le métabolome plasmatique par UPLC-MS \n(QToF). L’étude du métabolome montre que les niveaux circulants d’environ 50% des \nmétabolites détectés sont altérés lors de l’ingestion du repas, confortant l’idée que le \nrepas constitue un perturbateur majeur du phénotype des métabolites plasmatiques. \nLes analyses statistiques multivariées permettent la discrimination des animaux à jeun \ndes animaux nourris (quel que soit le point de cinétique). La trajectoire métabolique \npeut être expliquée en trois étapes : une 1 ère à t0, une 2 ème regroupant les points t1 et t2 \net une 3 ème comprenant les points t3 et t4. La différence entre les points t0 et t1-t2 peut \nêtre expliquée par l’augmentation des taux d’acides aminés et de glucides simples, ainsi \nque une forte diminution des taux des lipides. La rupture entre les points t1-t2 et t3-t4 \nreste encore inexpliquée et les identifications sont en cours pour expliquer cette \ndiscrimination spécifique. Nous avons ainsi montré que l’utilisation d’une approche \nglobale, la métabolomique, couplée à un modèle animal permettant une étude cinétique \nétait capable de discriminer des phases adaptatives spécifiques à l’ingestion du repas. \nNous avons ainsi décomposé en 3 étapes clés l’adaptation du métabolisme à l’ingestion \ndu repas test : à jeun, nourri après 1-2h et nourri après 3-4h. La connaissance de ces \ndonnées cinétiques est cruciale pour déterminer (i) les moments clés au cours desquels \ndes analyses du métabolisme plus approfondies mériteront d’être réalisées (ii) établir \ndes hypothèses sur les molécules et métabolites responsables des variations de \nl’homéostasie qui pourront être ciblées par la suite.
&lt;title&gt;Electric and magnetic field study of spacer layer thickness effects in A1GaAs/InGaAs resonant tunneling diodes&lt;/title&gt; (1990)

Pseudomorphic Al 35Ga 65As/In 1Ga 9As resonant tunneling diodes fabricated with asymmetric spacer layers adjaceht to the tunnel barrier were characterized via magneto-transport measurements. Novel tunneling effects (ground vs excited state tunneling) were observed in the current-voltage characteristics of these devices which depend upon the bias direction. Shubnikov-de Haas oscillations obtained at high magnetic fields show a strong asymmetry with bias direction and give evidence of silicon dopant out diffusion during molecular beam epitaxy.
Address-data event representation for communication in multichip neuromorphic system architectures (2007)

A new approach to asynchronous parallel-data conversion and transmission for computation in large neuromorphic distributed systems is reported. The proposed address data event representation (ADER) allows for efficient use of available bandwidth and ensures that no information is lost through collisions despite having a predominantly asynchronous nature.