gebhart/patrepeval huggingface dataset:
Polymer-phyllosilicate nanocomposites and their preparation (2023)

Polymer-phyllosilicate nanocomposites that exhibit superior properties compared to the polymer alone, and methods-for producing these polymer-phyllosilicate nanocomposites, are provided. Polymeric surfactant compatabilizers are adsorbed onto the surface of hydrophilic or natural phyllosilicates to facilitate the dispersal and exfoliation of the phyllosilicate in a polymer matrix. Utilizing polymeric glycol based surfactants, polymeric dicarboxylic acids, polymeric diammonium surfactants, and polymeric diamine surfactants as compatabilizers facilitates natural phyllosilicate and hydrophilic organoclay dispersal in a polymer matrix to produce nanocomposites.
Self-Trapping of Bosons and Fermions in Optical Lattices (2008)

We theoretically investigate the enhanced localization of bosonic atoms by fermionic atoms in three-dimensional optical lattices and find a self-trapping of the bosons for attractive boson-fermion interaction. Because of this mutual interaction, the fermion orbitals are substantially squeezed, which results in a strong deformation of the effective potential for bosons. This effect is enhanced by an increasing bosonic filling factor leading to a large shift of the transition between the superfluid and the Mott-insulator phase. We find a nonlinear dependency of the critical potential depth on the boson-fermion interaction strength. The results, in general, demonstrate the important role of higher Bloch bands for the physics of attractively interacting quantum gas mixtures in optical lattices and are of direct relevance to recent experiments with 87Rb-40K mixtures, where a large shift of the critical point has been found.
Cleavage by Calicheamicin .gamma.1I of DNA in a Nucleosome Formed on the 5S RNA Gene of Xenopus borealis (1995)

The cleavage by calicheamicin gamma 1I (CLM gamma 1I) of a nucleosome formed on the 5S RNA gene of Xenopus borealis was studied in vitro as a first step toward the understanding of CLM gamma 1I-chromatin interactions within the cell. The drug does not cleave in the region of the dyad axis of the nucleosome. Outside of this region, double-stranded cleavage occurs with a periodicity of 10-11 bp. The sites of cleavage correspond to DNA sequences facing outward in the nucleosome. The drug shows some sequence preference of cleavage within these accessible sites. The predominant cleavage event within this nucleosome occurs at -1 helical turn from the dyad axis. This site constitutes a "hot spot" for CLM gamma 1I cleavage within the 5S nucleosome. We observe an overall footprinting effect whereby the drug preferentially cleaves DNA located outside the nucleosome core (analogous to the linker DNA of chromatin) as compared to cleavage within the nucleosome core. We discuss the importance of accessibility, structural deformations of DNA within the nucleosome, and steric constraints posed by sequence, in the recognition and cleavage of nucleosomal DNA by calicheamicin.
Design, Synthesis, and Biological Activity of New <i>N</i>-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension (2018)

Macrophage migration inhibitory factor (MIF) is a key pleiotropic mediator and a promising therapeutic target in cancer as well as in several inflammatory and cardiovascular diseases including pulmonary arterial hypertension (PAH). Here, a novel series of N-(phenylmethyl)-benzoxazol-2-thiones 5-32 designed to target the MIF tautomerase active site was synthesized and evaluated for its effects on cell survival. Investigation of structure-activity relationship (SAR) particularly at the 5-position of the benzoxazole core led to the identification of 31 that potently inhibits cell survival in DU-145 prostate cancer cells and pulmonary endothelial cells derived from patients with idiopathic PAH (iPAH-ECs), two cell lines for which survival is MIF-dependent. Molecular docking studies helped to interpret initial SAR related to MIF tautomerase inhibition and propose preferred binding mode for 31 within the MIF tautomerase active site. Interestingly, daily treatment with 31 started 2 weeks after a subcutaneous monocrotaline injection regressed established pulmonary hypertension in rats.
SUN-593 Variants in Known Monogenic Causal Genes of Hypertriglyceridemia Are Not Major Contributors for Hypertriglyceridemia in Lipodystrophy Due to a LMNA Mutation (2020)

Abstract Background: Lipodystrophy is a heterogeneous disorder of adiposity, and one common lipid manifestation is hypertriglyceridemia (HTG). The LMNA gene, which encodes for nuclear envelope proteins, is a known causal gene for heritable lipodystrophy. At present, underlying mechanisms for each clinical manifestation of lipodystrophy due to a LMNA mutation are unknown. Hypothesis: A likely explanation for HTG in lipodystrophy is the paucity of adipose tissue where excess triglycerides (TGs) are normally stored, thus it may not be due to a specific defect in lipoprotein metabolism. Consequently, rare variants in HTG-associated genes would not be expected to be major contributors for HTG in lipodystrophy with LMNA mutations. Method: A proband and her father with a clinical diagnosis of lipodystrophy were recruited into an IRB-approved study investigating molecular etiologies of dyslipidemia at the University of Pennsylvania. Next-generation sequencing (NGS) with the LipidSeq panel, targeting causal genes for lipodystrophy, and monogenic HTG was performed, and confirmed by Sanger sequencing. Also, unweighted TG-polygenic scores by summing the number of TG-raising alleles from 14 single nucleotide polymorphisms (SNPs) associated with TG levels were assessed. Results: The proband and her father were diagnosed with lipodystrophy of two different subtypes, generalized in the daughter and partial in the father. The proband reported a gradual loss of subcutaneous fat starting around age 10. A highest reported TG in the proband was19,000 mg/dL with eruptive xanthomas, whereas TG in the father was never &amp;gt;500 mg/dL. Their BMI’s and DEXA body fat% were 12.9 kg/m2 and 7% in the proband, and 25.7 kg/m2 and 25% in the father, corresponding to their fat storage capacities. The molecular analyses revealed only a lipodystrophy causal mutation in LMNA, c.29C&amp;gt;T, T10I with no other significant findings in18 other lipodystrophy-related genes. No deletion or duplication was identified by a targeted array CGH of LMNA. As predicted, no rare monogenic variants in HTG-causal genes (LPL, GPIHBP1, APOA5, APOC2, LMF1, GPD1) were identified in either subject. However, TG-polygenic scores were 17/28 (95th %ile) in the proband, and 13/28 (50th %ile) in the father, the same trend as the level of HTG levels seen in them. Apolipoprotein E genotypes were non-contributory, (3/3) in the proband, and (3/4) in the father. Conclusion: Our findings support that the pathophysiology of HTG in lipodystrophy is likely to be due to lack of TG-storage space (adipose tissues), and is unlikely due to a defect in lipoprotein metabolism seen in patients with rare monogenic HTG-variants. Although the HTG-polygenic score was higher in the proband, and the accumulative effects of the at-risk alleles may be contributor to the HTG phenotype, it is unlikely to be the leading cause of severe HTG seen in the proband.
Industrial Applications of Ionic Liquids (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Pardicle: Parallel Approximate Density-Based Clustering (2014)

DBSCAN is a widely used is density-based clustering algorithm for particle data well-known for its ability to isolate arbitrarily-shaped clusters and to filter noise data. The algorithm is super-linear (O(nlogn)) and computationally expensive for large datasets. Given the need for speed, we propose a fast heuristic algorithm for DBSCAN using density based sampling, which performs equally well in quality compared to exact algorithms, but is more than an order of magnitude faster. Our experiments on astrophysics and synthetic massive datasets (8.5 billion numbers) shows that our approximate algorithm is up to 56x faster than exact algorithms with almost identical quality (Omega-Index = 0.99). We develop a new parallel DBSCAN algorithm, which uses dynamic partitioning to improve load balancing and locality. We demonstrate near-linear speedup on shared memory (15x using 16 cores, single node Intel® Xeon® processor) and distributed memory (3917x using 4096 cores, multinode) computers, with 2x additional performance improvement using Intel® Xeon Phi coprocessors. Additionally, existing exact algorithms can achieve up to 3.4 times speedup using dynamic partitioning.
ChemInform Abstract: Regioselective Electrophilic Fluorination of Rationally Designed Imidazole Derivatives. (2016)

Abstract Lithium tetramethylpiperidide is found to efficiently promote the regioselective fluorination of N‐protected 2‐substituted imidazoles (I) and (IV) to give the products regioselectively.
High-performance BiCMOS technologies without epitaxially-buried subcollectors and deep trenches (2006)

A 0.25 µm SiGe:C BiCMOS technology family (SG25H) with high-speed npn and pnp transistors for different performance requirements is presented. A CMOS-friendly integration scheme is realized by using collector wells, implanted after shallow trench formation, and avoiding deep trenches and extra collector sinkers. Three process variants are offered. The key bipolar transistor of the SG25H1 process is a 200 GHz npn device. The SG25H3 process offers three different types of npn HBTs. The performance ranges from fT/fmax /BVCEo values of 110 GHz/180 GHz/2.3 V for the high-speed (HS) device to 50 GHz/140 GHz/4.5 V for the medium voltage (MV) device and 30 GHz/80 GHz/6.5 V for the high-voltage (HV) transistor. The SG25H2 process provides in addition to npn transistors similar to those of SG25H1 and H3 a very high-speed SiGe:C pnp HBT with fT/fmax/BVCEo values of 90 GHz/120 GHz/2.8 V.
The role of ionic contamination in the in-plane smectic layer reorientation process (1998)

Abstract The influence of ionic contamination of a commercial ferroelectric liquid crystal on the dynamic behaviour of the smectic C layer reorientation was investigated with respect to its dependence on electric field asymmetry, amplitude, frequency and temperature. It is shown that ions within the liquid crystal sample greatly enhance the smectic layer reorientation at low frequencies. Especially the frequency dependence of the layer reorientation is discussed in some detail. In the framework of a qualitative interpretation the contribution of ionic motion causing a convective flow accounts for the smectic layer reorientation behaviour observed.
A low power temperature sensor based on a voltage to time converter cell (2013)

In this paper we propose a temperature sensor, based on a voltage to time converter cell (VTC). A VTC is frequently employed in time to digital converters for generating a delay that is proportional to the input voltage. The delay can then be digitized using a simple ripple counter at the output driven by a temperature independent clock. The power consumption of the proposed sensor is extremely low at 250nW, with an inaccuracy of +0.8°C to −1.5°C after two point calibration. A comparator with switchable bias currents is used to reduce the power consumption, while the temperature compensated current source is implemented using a low power current source. The sensor also exhibits high linearity over the 0 to 100 °C temperature range, while being powered by a 1.8V supply.
Advances in Anticancer Immunotoxin Therapy (2015)

Abstract Immunotoxins are a novel class of antibody-conjugated therapeutics currently in clinical development for a variety of malignancies. They consist of an antibody-based targeting domain fused to a bacterial toxin payload for cell killing. Immunotoxins kill cells by inhibiting protein synthesis, a unique mechanism of action that is toxic to both dividing and nondividing cells. Recent advances in the design and administration of immunotoxins are overcoming historical challenges in the field, leading to renewed interest in these therapeutics.
Near-infrared diffuse in vivo flow cytometry (2022)

NIR-DiFC allows use of emerging NIR contrast agents. Our work could pave the way for future use of NIR-DiFC in humans.
Antiplatelet, antineutrophil and vasodilating properties of 13,14-dihydro-PGE1 (PGE0)--an in vivo metabolite of PGE1 in man. (1991)

The actions of the in vivo metabolite of PGE1, 13,14-dihydro-PGE1 (PGE0), on platelet and neutrophil (PMN) function and vessel tone were studied in vitro. PGE0 inhibited aggregation, ATP release and thromboxane generation by human platelets (IC50 10-100 nmoles/l). The compound also inhibited superoxide anion generation and lysosomal enzyme release from human PMN. PGE0 was equipotent to PGE1 in both systems, while 15-keto-PGE1 was ineffective in platelets but produced some inhibition in PMN. These inhibitory effects of PGE0 and PGE1 were paralleled by concentration-dependent increases in cyclic AMP in platelets and PMN. Both compounds were also potent relaxants of several arterial preparations in the rabbit at comparable concentrations. In general, the vasorelaxing properties of PGE0 were somewhat lower and the contractile effects somewhat stronger in comparison to PGE1. These data demonstrate a significant and concentration-dependent inhibition of receptor-mediated activation of human platelets and PMN by PGE0. The molar potency of the compound is comparable to that of PGE1. Generation of PGE0 from infused PGE1 may contribute to the clinical efficacy of PGE1 in treatment of severe peripheral arterial occlusive disease.
Industry and business perspectives on the distinctions between visually lossless and lossy video quality: Mobile and large format displays (2017)

This paper will explore the mobile and business perspectives of visually lossless image quality, as well as review recent scientific advances. It is the outcome from the Special Session on Visually Lossless Video Quality for Modern Devices: Research and Industry Perspectives organized at the Human Vision and Electronic Imaging 2017 by IS&amp;T at San Francisco Airport, Burlingame, California, USA, Jan 29 - Feb 2, 2017. It summarizes four presentations and a panel discussion.
Engineering bacterial thiosulfate and tetrathionate sensors for detecting gut inflammation (2017)

There is a groundswell of interest in using genetically engineered sensor bacteria to study gut microbiota pathways, and diagnose or treat associated diseases. Here, we computationally identify the first biological thiosulfate sensor and an improved tetrathionate sensor, both two-component systems from marine <i>Shewanella</i> species, and validate them in laboratory <i>Escherichia coli</i> Then, we port these sensors into a gut-adapted probiotic <i>E. coli</i> strain, and develop a method based upon oral gavage and flow cytometry of colon and fecal samples to demonstrate that colon inflammation (colitis) activates the thiosulfate sensor in mice harboring native gut microbiota. Our thiosulfate sensor may have applications in bacterial diagnostics or therapeutics. Finally, our approach can be replicated for a wide range of bacterial sensors and should thus enable a new class of minimally invasive studies of gut microbiota pathways.
Chronic Urticaria and Angioedema (2002)

A 35-year-old woman presents with a three-month history of daily generalized hives. She has also had swelling of her lips and tongue, with associated tightness of the throat. How should she be evaluated and treated?
High Affinity IgG Receptor Activation of Src Family Kinases Is Required for Modulation of the Shc-Grb2-Sos Complex and the Downstream Activation of the Nicotinamide Adenine Dinucleotide Phosphate (Reduced) Oxidase (1999)

We used the U937 cell line to examine the modulation of adaptor protein interactions (Shc, Grb2, and Cbl) after high affinity IgG receptor (FcgammaRI) cross-linking, leading to the formation of the Grb2-Sos complex, the activation of Ras, and the regulation of the respiratory burst. Cross-linking of FcgammaRI induced the conversion of GDP-Ras to GTP-Ras reaching a maximum 5 min after stimulation. Concomitant with Ras activation, Sos underwent an electrophoretic mobility shift and the Sos-Grb2 association was increased (6-fold). The Grb2-Sos complex was present only in the membrane fraction and was augmented after FcgammaRI stimulation. Tyrosine-phosphorylated Shc, mainly the p52 isoform, was observed to transiently onload to the membrane Grb2-Sos complex on FcgammaRI stimulation. Cross-linking of FcgammaRI induces the tyrosine phosphorylation of Cbl, which forms a complex with Grb2 and Shc via the Cbl C terminus. Kinetic experiments confirm that Cbl-Grb2 is relatively stable, whereas Grb2-Sos, Grb2-Shc, and Cbl-Shc interactions are highly inducible. The Src family tyrosine kinase inhibitor, PP1, was shown to completely inhibit Shc tyrosine phosphorylation, the Shc-Grb2 interaction, and the FcgammaR-induced respiratory burst. Our results provide the first evidence that the upstream activation of Src kinases is required for the modulation of the Shc-Grb2 interaction and the myeloid NADPH oxidase response.
Hot-Rolled Steels: Microstructural Evolution Prediction (2016)

In this entry, mathematical models for predicting microstructural evolution during hot deformation and subsequent cooling, and mechanical properties from the resultant microstructure of steels are explained. These models include some empirical parameters although they are based on theory. Although the models include some empirical parameters, they are very useful for investigating production conditions such as chemical compositions, processing conditions and so on. The accuracy of predicted mechanical properties is satisfactory. It is noted that these models should be widely used for off-line simulation of designing steel compositions and processing condition and on-line simulation for guaranteeing mechanical properties of steels.
All-Optical Switching In Silicon Ring Resonators (2014)

We demonstrate selective all-optical control of a single resonance in a silicon micro-ring resonator using Raman-induced loss. This enables a single micro-ring to act as a broadband reconfigurable all-optical add-drop multiplexer (ROADM).
Demagnetization Fault Detection in Axial Flux PM Machines by Using Sensing Coils and an Analytical Model (2017)

The paper studies demagnetization detection in axial flux permanent magnet synchronous machines of the yokeless and segmented armature (YASA) type. In YASA machines, asymmetrical defects can occur: the demagnetization defects in the permanent magnets of both rotors differ from each other. Many techniques can indicate that there is a defect, even if it is an asymmetrical defect, but cannot detect which rotor has the defect, i.e., exactly locate the asymmetrical defect. In this paper, a method is proposed to detect and locate asymmetrical demagnetization defects in AFPMSMs. The method is useful for real-time condition monitoring of demagnetization defects, or as virtual temperature sensor for the magnets. A sensing coil is placed in each air gap. An analytical model is constructed, which uses the demagnetization defect and the three-phase current as input and calculates the sensing coil back-EMF. Sensing coils back-EMF data are combined with the data from the analytical model to solve an electromagnetic inverse problem. The results are the demagnetization amount and location of the demagnetization defect. The method is validated with the experimental data.
Thermodynamic Properties of the Calcium Ferrites CaFe<sub>2</sub>O<sub>4</sub> and Ca<sub>2</sub>Fe<sub>2</sub>O<sub>5</sub> (1999)

The chemical potentials of CaO in the two-phase fields Fe2O3 + CaFe2O4 and CaFe2O4 + Ca2Fe2O5 of the pseudobinary system CaO - Fe2O3 have been measured in the temperature range from 975 to 1275 K, relative to pure CaO as the reference state, using solid state galvanic cells incorporating single-crystal CaF2 as the solid electrolyte. The cell was operated under pure oxygen at ambient pressure. The standard Gibbs energies of formation of calcium ferrites, CaFe2O4 and Ca2Fe2O5, were derived from the reversible emfs. The results can be summarized by the following equations:CaO + Fe2O3 --> CaFe2O4;Delta G degrees = - 37,480 + 1.16 T (+/- 250) J/mol 2 CaO + Fe2O3 --> Ca2Fe2O5;Delta G degrees = - 45, 280 - 13.51 T (+/- 275) J/mol These values are compared with thermodynamic data reported in the literature. The results of this study are in excellent agreement with heat capacity data, and in reasonable agreement with earlier measurements of enthalpy and Gibbs energy of formation, but suggest significant revision of enthalpies of formation of calcium ferrites given in current thermodynamic compilations.
Development and content validation of a patient-reported endometriosis pain daily diary (2018)

The EPDD is a PRO for the evaluation of endometriosis-related pain and its associated impacts on patients' lives. The EPDD represents an important step in providing a PRO that is relevant to patients with endometriosis-related pain in the context of a clinical study setting (ie, fit-for-purpose), designed to evaluate pain associated with endometriosis, including regulatory agency support for its further exploration in clinical trials.
Metabolic Profiling and Flux Analysis of MEL-2 Human Embryonic Stem Cells during Exponential Growth at Physiological and Atmospheric Oxygen Concentrations (2014)

As human embryonic stem cells (hESCs) steadily progress towards regenerative medicine applications there is an increasing emphasis on the development of bioreactor platforms that enable expansion of these cells to clinically relevant numbers. Surprisingly little is known about the metabolic requirements of hESCs, precluding the rational design and optimisation of such platforms. In this study, we undertook an in-depth characterisation of MEL-2 hESC metabolic behaviour during the exponential growth phase, combining metabolic profiling and flux analysis tools at physiological (hypoxic) and atmospheric (normoxic) oxygen concentrations. To overcome variability in growth profiles and the problem of closing mass balances in a complex environment, we developed protocols to accurately measure uptake and production rates of metabolites, cell density, growth rate and biomass composition, and designed a metabolic flux analysis model for estimating internal rates. hESCs are commonly considered to be highly glycolytic with inactive or immature mitochondria, however, whilst the results of this study confirmed that glycolysis is indeed highly active, we show that at least in MEL-2 hESC, it is supported by the use of oxidative phosphorylation within the mitochondria utilising carbon sources, such as glutamine to maximise ATP production. Under both conditions, glycolysis was disconnected from the mitochondria with all of the glucose being converted to lactate. No difference in the growth rates of cells cultured under physiological or atmospheric oxygen concentrations was observed nor did this cause differences in fluxes through the majority of the internal metabolic pathways associated with biogenesis. These results suggest that hESCs display the conventional Warburg effect, with high aerobic activity despite high lactate production, challenging the idea of an anaerobic metabolism with low mitochondrial activity. The results of this study provide new insight that can be used in rational bioreactor design and in the development of novel culture media for hESC maintenance and expansion.