gebhart/patrepeval huggingface dataset:
Detectability of biosignatures on LHS 1140 b (2021)

Context. Terrestrial extrasolar planets around low-mass stars are prime targets when searching for atmospheric biosignatures with current and near-future telescopes. The habitable-zone super-Earth LHS 1140 b could hold a hydrogen-dominated atmosphere, and is an excellent candidate for detecting atmospheric features. Aims. In this study we investigate how the instellation and planetary parameters influence the atmospheric climate, chemistry, and spectral appearance of LHS 1140 b. We study the detectability of selected molecules, in particular potential biosignatures, with the upcoming James Webb Space Telescope (JWST) and Extremely Large Telescope (ELT). Methods. In the first step we used the coupled climate–chemistry model 1D-TERRA to simulate a range of assumed atmospheric chemical compositions dominated by molecular hydrogen (H2) and carbon dioxide (CO2). In addition, we varied the concentrations of methane (CH4) by several orders of magnitude. In the second step we calculated transmission spectra of the simulated atmospheres and compared them to recent transit observations. Finally, we determined the observation time required to detect spectral bands with low-resolution spectroscopy using JWST, and the cross-correlation technique using ELT. Results. In H2-dominated and CH4-rich atmospheres oxygen (O2) has strong chemical sinks, leading to low concentrations of O2 and ozone (O3). The potential biosignatures ammonia (NH3), phosphine (PH3), chloromethane (CH3Cl), and nitrous oxide (N2O) are less sensitive to the concentration of H2, CO2, and CH4 in the atmosphere. In the simulated H2-dominated atmosphere the detection of these gases might be feasible within 20 to 100 observation hours with ELT or JWST when assuming weak extinction by hazes. Conclusions. If further observations of LHS 1140 b suggest a thin, clear, hydrogen-dominated atmosphere, the planet would be one of the best known targets to detect biosignature gases in the atmosphere of a habitable-zone rocky exoplanet with upcoming telescopes.
Cardiovascular events in elderly patients with isolated systolic hypertension. A subgroup analysis of treatment strategies in STOP‐Hypertension‐2 (2004)

The analysis demonstrated that "newer" therapy (ACE inhibitors/calcium antagonists) was significantly better (25%) than "conventional" (diuretics/beta-blockers) in preventing all stroke in elderly patients with isolated systolic hypertension.
Human herpesvirus 6 (HHV‐6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV‐6 DNA (2004)

We obtained 7,566 peripheral blood mononuclear cell (PBMC) samples from 2,332 individuals and screened them for human herpesvirus infection. We identified five individuals who persistently harbored high copy numbers of human herpesvirus 6 (HHV-6) DNA in their PBMCs. HHV-6 DNA was also detected in other somatic tissues of these individuals. Five additional cases were identified among their family members. For two of these families, chromosomally integrated HHV-6 DNA (CIHHV-6) was detected in the PBMCs by fluorescence in situ hybridization. The prevalence of CIHHV-6 among all the subjects was 0.21%. The HHV-6 DNA was variant B in four families and variant A in one family. Antibodies to immediate early antigen and glycoprotein B were detected in 57 and 14% of individuals with CIHHV-6 and in 0 and 60% of healthy volunteers without CIHHV-6, respectively. HHV-6 could not be isolated from PBMCs with CIHHV-6. These cases shared no clinical features, and included three healthy individuals. Our data suggest that CIHHV-6 is rare but detectable in the general population and that hereditary transmission is one of the routes of HHV-6 transmission.
Cold‐Ion Spectroscopy Reveals the Intrinsic Structure of a Decapeptide (2011)

Trapped, cooled, solved: Cold-ion spectroscopy was used to solve the three-dimensional gas-phase structure of the natural decapeptide gramicidin S. Experiments provide a detailed set of spectroscopic and structural constraints that unambiguously identify the most stable calculated structure of the isolated peptide. These results provide new information for modeling the biological activity of this antibiotic. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Viral Infection and Abnormal Brain Development: A DNA Microarray Study (2007)

Maternal viral infection is known to increase the risk for schizophrenia and autism in their offspring (Brown et al, 2004). C57BL/6 mice were infected with human influenza virus on day E18 of pregnancy and brains were collected at PN days 0, 14, or 56, from virally‐exposed (N=3) or sham‐infected control's (N=3) offspring. Microarray analysis of virally‐exposed mouse brains showed significant (p&lt;0.05) upregulation of 15 genes and downregulation of 3 genes in cerebellum, upregulation of 42 genes and downregulation of 9 genes in hippocampus, and upregulation of 4 genes and downregulation of 5 genes in prefrontal cortex vs. controls in day 0 mice. At day 14, there was a significant upregulation of 2 genes and downregulation of 0 genes in cerebellum, upregulation of 1 gene and downregulation of 1 gene in hippocampus, and upregulation of 3 genes and downregulation of 3 genes in prefrontal cortex vs. controls. At day 56, there was a significant upregulation of 13 genes and downregulation of 2 genes in cerebellum, upregulation of 4 genes and downregulation of 3 genes in hippocampus, and upregulation of 4 genes and downregulation of 1 gene in prefrontal cortex vs. controls. Implications of changes in brain genes for development of abnormal brain structure and function will be discussed. The generous support by the National Institute for Child Health and Human Development (1‐R01‐ HD046589 ‐01A2) to S.H.F. is greatly appreciated.
Double-Walled Carbon Nanotube Solar Cells (2007)

We directly configured double-walled carbon nanotubes as energy conversion materials to fabricate thin-film solar cells, with nanotubes serving as both photogeneration sites and a charge carriers collecting/transport layer. The solar cells consist of a semitransparent thin film of nanotubes conformally coated on a n-type crystalline silicon substrate to create high-density p-n heterojunctions between nanotubes and n-Si to favor charge separation and extract electrons (through n-Si) and holes (through nanotubes). Initial tests have shown a power conversion efficiency of >1%, proving that DWNTs-on-Si is a potentially suitable configuration for making solar cells. Our devices are distinct from previously reported organic solar cells based on blends of polymers and nanomaterials, where conjugate polymers generate excitons and nanotubes only serve as a transport path.
General dual-band coordinate transformation media with full-tensor anisotropic dispersion controls (2021)

We propose general dual-band coordinate transformation media realizing two arbitrary coordinate transformations at two target frequencies and their universal implementation method by LC-based circuit metamaterials with full-tensor anisotropic dispersion controls. The circuit topologies to fully manipulate the material parameters to be realized are discussed. The general quantitative relations of the equivalent material parameters in two arbitrary coordinate transformations are classified into six cases, and the five fundamental branch unit constituents to cover all the six cases are presented. As an example, a dual-band illusion device with peculiar dispersions mimicking a bump and a pothole at each frequency is designed based on the presented implementation method. The illusion operations of the designed medium for 0 and ${45}^{\ensuremath{\circ}}$ incidences are numerically demonstrated by circuit simulations, and the validities of the proposed concept and the implementation method are confirmed.
Microfluidic impact printer with interchangeable cartridges for versatile non-contact multiplexed micropatterning (2013)

Biopatterning has been increasingly used for well-defined cellular microenvironment, patterned surface topology, and guided biological cues; however, it meets challenges on biocompatibility, thermal and chemical sensitivity, as well as limited availability of reagents. In this paper, we aim at combining the desired features from non-contact inkjet printing and dot-matrix impact printing to establish a versatile multiplexed micropatterning platform, referred to as Microfluidic Impact Printer (MI-Printer), for emerging biomedical applications. Using this platform, we can achieve the distinct features of no cross-contamination, sub-microliter ink loading with a minimal dead volume, high-throughput printing, biocompatible non-contact processing, sequential patterning with self-alignment, wide adaptability for complex media (e.g., cell suspension or colloidal solutions), interchangeable/disposable cartridge design, and simple assembly and configuration, all highly desirable towards laboratory-based research and development. Specifically, the printing resolution of the MI-printer platform has been experimentally characterized and theoretically analysed. Optimal printing resolution of 80 μm has been repeatedly obtained. Furthermore, two useful functions of the MI-printer, multiplexed printing and combinatorial printing, have been experimentally demonstrated with less than 10 μm misalignment. Moreover, molecular and biological patterning, utilizing the multiplexed and combinatorial printing, has been implemented to illustrate the utility of this versatile printing technique for emerging biomedical applications.
Marburg and Ebola Virus Infections Elicit a Complex, Muted Inflammatory State in Bats (2023)

The Marburg and Ebola filoviruses cause a severe, often fatal, disease in humans and nonhuman primates but have only subclinical effects in bats, including Egyptian rousettes, which are a natural reservoir of Marburg virus. A fundamental question is why these viruses are highly pathogenic in humans but fail to cause disease in bats. To address this question, we infected one cohort of Egyptian rousette bats with Marburg virus and another cohort with Ebola virus and harvested multiple tissues for mRNA expression analysis. While virus transcripts were found primarily in the liver, principal component analysis (PCA) revealed coordinated changes across multiple tissues. Gene signatures in kidney and liver pointed at induction of vasodilation, reduction in coagulation, and changes in the regulation of iron metabolism. Signatures of immune response detected in spleen and liver indicated a robust anti-inflammatory state signified by macrophages in the M2 state and an active T cell response. The evolutionary divergence between bats and humans of many responsive genes might provide a framework for understanding the differing outcomes upon infection by filoviruses. In this study, we outline multiple interconnected pathways that respond to infection by MARV and EBOV, providing insights into the complexity of the mechanisms that enable bats to resist the disease caused by filoviral infections. The results have the potential to aid in the development of new strategies to effectively mitigate and treat the disease caused by these viruses in humans.
Regulation of Adolescent Sleep: Implications for Behavior (2004)

Adolescent development is accompanied by profound changes in the timing and amounts of sleep and wakefulness. Many aspects of these changes result from altered psychosocial and life-style circumstances that accompany adolescence. The maturation of biological processes regulating sleep/wake systems, however, may be strongly related to the sleep timing and amount during adolescence-either as "compelling" or "permissive" factors. The two-process model of sleep regulation posits a fundamental sleep-wake homeostatic process (process S) working in concert with the circadian biological timing system (process C) as the primary intrinsic regulatory factors. How do these systems change during adolescence? We present data from adolescent participants examining EEG markers of sleep homeostasis to evaluate whether process S shows maturational changes permissive of altered sleep patterns across puberty. Our data indicate that certain aspects of the homeostatic system are unchanged from late childhood to young adulthood, while other features change in a manner that is permissive of later bedtimes in older adolescents. We also show alterations of the circadian timing system indicating a possible circadian substrate for later adolescent sleep timing. The circadian parameters we have assessed include phase, period, melatonin secretory pattern, light sensitivity, and phase relationships, all of which show evidence of changes during pubertal development with potential to alter sleep patterns substantially. However the changes are mediated-whether through process S, process C, or by a combination-many adolescents have too little sleep at the wrong circadian phase. This pattern is associated with increased risks for excessive sleepiness, difficulty with mood regulation, impaired academic performance, learning difficulties, school tardiness and absenteeism, and accidents and injuries.
Effects of Patisiran, an RNA Interference Therapeutic, on Cardiac Parameters in Patients With Hereditary Transthyretin-Mediated Amyloidosis (2019)

URL: https://www.clinicaltrials.gov . Unique identifier: NCT01960348.
Reducing Carrier Density in Formamidinium Tin Perovskites and Its Beneficial Effects on Stability and Efficiency of Perovskite Solar Cells (2017)

In Sn-based halide perovskite solar cells (PSCs), the oxidation of Sn2+ to Sn4+ under ambient air leads to unwanted p-type doping in the perovskite film, which is a main reason for increased background carrier density and low efficiency. Here, we find that the introduction of bromide into formamidinium tin iodide (CH(NH2)2SnI3, FASnI3) lattice significantly lowers the carrier density of perovskite absorber, which is thought to be a result of reduction of Sn vacancies. It reduces the leakage current of devices, increases recombination lifetime, and finally improves open-circuit voltage and fill factor of the resulting devices employing mesoporous TiO2 as an electron transport layer. Consequently, a high power conversion efficiency (PCE) of 5.5% is achieved with an average PCE of 5%, and after encapsulation the devices are highly stable over 1000 h under continuous one sun illumination including the ultraviolet region. This study suggests a simple approach for improving stability and efficiency in FASnI3-based PSCs.
A Traceless Approach for the Solid-Phase Parallel Synthesis of Trisubstituted Oxindoles (2008)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionA Traceless Approach for the Solid-Phase Parallel Synthesis of Trisubstituted OxindolesJinwen Xie, Jing Sun, Guolin Zhang, Richard A. Houghten, and Yongping Yu*Cite this: J. Comb. Chem. 2008, 10, 5, 752Publication Date (Web):August 14, 2008Publication History Received21 July 2008Published online14 August 2008Published inissue 8 September 2008https://pubs.acs.org/doi/10.1021/cc8001266https://doi.org/10.1021/cc8001266correctionACS PublicationsCopyright © 2008 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views442Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (16 KB) SUBJECTS:Chemical synthesis,Crystal cleavage,Oxindoles,Sulfur Get e-Alerts
Simultaneous two-wavelength transmission quantitative phase microscopy with a color camera (2010)

We present a quantitative phase microscopy method that uses a Bayer mosaic color camera to simultaneously acquire off-axis interferograms in transmission mode at two distinct wavelengths. Wrapped phase information is processed using a two-wavelength algorithm to extend the range of the optical path delay measurements that can be detected using a single temporal acquisition. We experimentally demonstrate this technique by acquiring the phase profiles of optically clear microstructures without 2pi ambiguities. In addition, the phase noise contribution arising from spectral channel crosstalk on the color camera is quantified.
A fast DFT algorithm using complex integer transforms (1978)

Winograd's algorithm for computing the discrete Fourier transform is extended considerably for certain large transform lengths. This is accomplished by performing the cyclic convolution, required by Winograd's method, by a fast transform over certain complex integer fields. This algorithm requires fewer multiplications than either the standard fast Fourier transform or Winograd's more conventional algorithms.
Maximally Distant Cross Domain Generators for Estimating Per-Sample Error. (2017)

While in supervised learning, the validation error is an unbiased estimator of the generalization (test) error and complexity-based generalization bounds are abundant, no such bounds exist for learning a mapping in an unsupervised way. As a result, when training GANs and specifically when using GANs for learning to map between domains in a completely unsupervised way, one is forced to select the hyperparameters and the stopping epoch by subjectively examining multiple options. We propose a novel bound for predicting the success of unsupervised cross domain mapping methods, which is motivated by the recently proposed simplicity hypothesis. The bound can be applied both in expectation, for comparing hyperparameters, or per sample, in order to predict the success of a specific cross-domain translation. The utility of the bound is demonstrated in an extensive set of experiments employing multiple recent algorithms.
Towards stronger jamming model: Application to TH-UWB radio (2012)

With the great expansion of wireless communications, jamming becomes a real threat. We propose a new model to evaluate the robustness of a communication system to jamming. The model results in more scenarios to be considered ranging from the favorable case to the worst case. The model is applied to a TH-UWB radio. The performance of such a radio in presence of the different jamming scenarios is analyzed. We introduce a mitigation solution based on stream cipher that restricts the jamming problem of the TH-UWB communication to the more favorable case while preserving confidentiality.
Multicast routing under optical layer constraints (2004)

It has been widely recognized that physical layer impairments, including power losses, must be taken into account when routing optical connections in transparent networks. In this paper we study the problem of constructing light-trees under optical layer power budget constraints, with a focus on algorithms which can guarantee a certain level of quality for the signals received by the destination nodes. We define a new constrained light-tree routing problem by introducing a set of constraints on the source-destination paths to account for the power losses at the optical layer. We investigate a number of variants of this problem, we characterize their complexity, and we develop a suite of corresponding routing algorithms; one of the algorithms is appropriate for networks with sparse light splitting and/or limited splitting fanout. We find that, in order to guarantee an adequate signal quality and to scale to large destination sets, light-trees must be as balanced as possible. Numerical results demonstrate that existing algorithms tend to construct highly unbalanced trees, and are thus expected to perform poorly in an optical network setting. Our algorithms, on the other hand, are designed to construct balanced trees which, in addition to having good performance in terms of signal quality, they also ensure a certain degree of fairness among destination nodes. While we only consider power loss in this work, the algorithms we develop could be appropriately modified to account for other physical layer impairments, such as dispersion.
Machine learning–assisted global optimization of photonic devices (2021)

Over the past decade, artificially engineered optical materials and nanostructured thin films have revolutionized the area of photonics by employing novel concepts of metamaterials and metasurfaces where spatially varying structures yield tailorable “by design” effective electromagnetic properties. The current state-of-the-art approach to designing and optimizing such structures relies heavily on simplistic, intuitive shapes for their unit cells or metaatoms. Such an approach cannot provide the global solution to a complex optimization problem where metaatom shape, inplane geometry, out-of-plane architecture, and constituent materials have to be properly chosen to yield the maximum performance. In this work, we present a novel machine learning-assisted global optimization framework for photonic metadevice design. We demonstrate that using an adversarial autoencoder (AAE) coupledwith ametaheuristic optimization framework significantly enhances the optimization search efficiency of the metadevice configurations with complex topologies. We showcase the concept of physics-driven compressed design space engineering that introduces advanced regularization into the compressed space of an AAE based on the optical responses of the devices. Beyond the significant advancement of the global optimization schemes, our approach can assist in gaining comprehensive design “intuition” by revealing the underlying physics of the optical performance ofmetadevices with complex topologies and material compositions.