gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Free‐Radical Telomerization of Chiral Acrylamides: Control of Stereochemistry in Additions and Halogen‐Atom Transfer. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Archetípus és új értelmezés, Matadero Nave 16, Madrid, Spanyolország (2012)

Madrid központjától délre, a Manzanares folyó partján épült fel az 1910-es években a város vágóhídja (sp. Matadero). A Luis Bellido tervezte együttes a 20. század eleji ipari építészet egyik kiemelkedő példája. A historizáló stílusú, neo-mudejár elemekkel ötvözött csarnokok egészen a 90-es évekig használatban voltak. Ekkor döntött úgy a város vezetése, hogy a folyópark rehabilitációjának keretében a jó fekvésű épületekbe kortárs kulturális központot telepít, a művészeti negyed múzeumait felfűző Paseo del Prado sugárút meghosszabbításaként. A különböző csarnokok átalakítására építészeti tervpályázatot írtak ki, a nyertes munkák egy része már átadásra került (Arturo Franco – Intermediae, Antón García-Abril – Casa del Lector). A Nave 16 nevet viselő csarnok az egész beavatkozás szempontjából kulcsfontosságú, mivel a folyó mentén, az új megközelítés felől határolja a volt ipari területet, tehát a várossal való kommunikáció fő felületét adja.
Alternative representation of time-dependent Hamiltonians with application to laser-driven systems (2002)

A representation of time-dependent Hamiltonians that describe laser-driven systems is presented. Unlike the well-known time-independent dressed potentials that are functions of the characteristic parameter ${\ensuremath{\alpha}}_{0}=\sqrt{I}/{\ensuremath{\omega}}^{2},$ where $\ensuremath{\omega}$ and I are the laser frequency and intensity, this approach provides a time-averaged potential that depends explicitly on the field parameters; e.g., I, $\ensuremath{\omega},$ and shape of the laser pulse. The modified dressed potential is $\ensuremath{\Elzxh}$ independent and adds a classical time-independent potential barrier to the Kramers-Henneberger dressed potential. We show that this dynamical potential barrier is identical to the Kapitza effective classical potential energy obtained for the motion of a particle in a rapidly oscillating field. As an illustrative numerical example, a simple one-electron effective model Hamiltonian of xenon atom in strong laser field is studied. We show that the zero-order quasienergies obtained by our representation are reasonably accurate and the second order high-frequency perturbation calculations provide quite accurately the lifetime of the photoionized electron for a broad range of laser frequencies.
Supplementary Figure 1 from Tumor Detection by Imaging Proteolytic Activity (2023)

Supplementary Figure 1 from Tumor Detection by Imaging Proteolytic Activity
Quality Control in Remote Speech Data Collection (2019)

There is a need for algorithms that can automatically control the quality of the remotely collected speech databases by detecting potential outliers, which deserve further investigation. In this paper, a simple and effective approach for identification of outliers in a speech database is proposed. Using the deterministic minimum covariance determinant (DetMCD) algorithm to estimate the mean and covariance of the speech data in the mel-frequency cepstral domain, this approach identifies potential outliers based on the statistical distance of the observations in the feature space from the central location of the data that are larger than a predefined threshold. DetMCD is a computationally efficient algorithm, which provides a highly robust estimate of the mean and covariance of multivariate data even when 50% of the data are outliers. Experimental results using eight different speech databases with manually inserted outliers show the effectiveness of the proposed method for outlier detection in speech databases. Moreover, applying the proposed method to a remotely collected Parkinson's voice database shows that the outliers that are part of the database are detected with 97.4% accuracy, resulting in a significant decrease in the effort required for manually controlling the quality of the database.
Spinal Disassociation Masquerading as Iatrogenic Listhesis Above a Previous Fusion (2006)

Adjacent segment degeneration next to a prior lumbar fusion may be associated with extreme instability. Treatment may require complex stabilization.
Simulation and measurement of an electron beam in a wiggler magnetic field (1989)

Sources of high quality beams of spinning electron beams are critical to efficient free electron devices including FELs, CARMs and gyrotrons. Bifilar helical wigglers can take a beam with little perpendicular momentum and add perpendicular momentum, spinning up the beam. The effect of the electron beam self fields on the beam quality will be important. A computer simulation has been written which can simulate the behavior of electron beams in the wiggler region including the effects of the beam self-electric fields. The equations used in the code are described. Several tests of the code are presented. Results of simulation of a bifilar helical wiggler are described. Measurement of beam parameters is also necessary. A design for a capacitive axial velocity probe is presented. The probe has been built but is still untested due to problems with a leaky flange. 15 refs.
Figure S1 from The Elongin BC Complex Negatively Regulates AXL and Marks a Differentiated Phenotype in Melanoma (2023)

&lt;p&gt;Extended data on Figure 1: Whole genome-wide CRISPR-Cas9 screenidentifies several negative regulators of AXL.&lt;/p&gt;
Self-starting Kerr-mode-locked polycrystalline Cr&lt;sup&gt;2+&lt;/sup&gt;:ZnSe laser (2008)

We demonstrate a middle-infrared self-starting Kerr-mode-locked Cr:ZnSe laser operating at 103 MHz repetition-rate with estimated lower limit of the pulse width of 300 fs and output power of 50 mW at 2.4 mum wavelength.
Flow field-flow fractionation hyphenated with inductively coupled plasma mass spectrometry: a robust technique for characterization of engineered elemental metal nanoparticles in the environment (2021)

Due to the increased applications of engineered elemental metal nanoparticles (EMNPs) in recent years, increased attention has been devoted to their release into the environment. EMNPs pose potential risks to living organisms, including human beings. Hence, the characterization of EMNPs in the environment has gained significant importance. Among the various techniques reported for the characterization of EMNPs, on-line coupling of flow field-flow fractionation with inductively coupled plasma mass spectrometry (F4-ICPMS) has been well established for the simultaneous separation, identification, and quantification of EMNPs, especially in the complex matrices of environmental samples. Thus, this review focuses on the specific advantages of the F4 method, especially the asymmetrical F4 (AF4) and hollow fiber F4 (HF5) methods, in the separation of EMNPs, the general development of AF4-ICPMS and HF5-ICPMS techniques, and recent advances in the application of these hyphenated techniques in examining the occurrence and transformation of EMNPs in the environment. Finally, several perspectives on these techniques have been put forward.
Arrival to the City (1991)

The projects to follow are shamanic acts, trying to heal the "eternal wound of existence," of life and architecture. The healing occurs through acts and events which constitute the discourse of arrival to an ideal city.
Etude de la physiopathologie de la polyglobulie de Vaquez : recherche d' anomalies dans la transduction du signal : Identification d'une mutation clonale de JAK2 (2008)

La polyglobulie de Vaquez (PV) est un syndrome myeloproliferatif correspondant a une maladie acquise de la cellule souche hematopoietique. Les progeniteurs erythroblastiques de PV presentent des anomalies de reponse aux cytokines. L'objectif principal de notre travail etait de comprendre les mecanismes moleculaires impliques dans ces anomalies de reponse. Nous avons mis au point d'un systeme de culture permettant l'etude in vitro des precurseurs erythroblastiques purifie��s. Les resultats obtenus ont montre que l'existence d'une differenciation erythroblastique terminale en l'absence d'erythropoietine est l'anomalie principale dans la PV. En ajoutant des inhibiteurs biochimiques des differentes voies de transduction du signal, nous avons montre que les voies JAK2-STAT5, PI3-kinase, et Src kinases etaient necessaires impliquees. Nous avons ensuite montre que l'inhibition de specifique de JAK2 entrainait une diminution de la differenciation independante de l'Epo et qu'il existait une phosphorylation prolongee de JAK2 apres sevrage en cytokines chez les PV. Enfin, le sequencage de JAK2 a revele une mutation ponctuelle presente plus de 80% des cas de PV, et dans 30-50% des syndromes myeloproliferatifs bcr-abl negatifs. Des experiences de transfection du gene mute ont montre responsabilite de cette mutation dans l'independance aux cytokines et le developpement d'une polyglobulie. La decouverte de la mutation JAK V617F represente une avancee importante dans la comprehension de la physiopathologie de la PV. Nos resultats permettent le developpement de modeles cellulaires et animaux de la maladie et ouvrent des perspectives pour le diagnostic et le traitement.
Improved media for growth and aerotolerance of Campylobacter fetus (1978)

The microaerophilic nature of Campylobacter fetus has complicated its recovery from human and animal sources. In this study, modifications of brucella agar and broth were tested for enhancement of growth and aerotolerance of 64 strains of C. fetus, representing each subspecies. Brucella agar supplemented with 0.025% each FeSO4 7H2O, sodium metabisulfite, and sodium pyruvate, supported growth of 98, 77, and 63% of the strains at 6% O2, 17% O2, and 21% O2, respectively. Unsupplemented brucella agar supported growth of 94, 48, and 20% of the strains. Brucella broth supplemented with 0.2% FeSO4.7H2O, 0.025% sodium metabisulfite, and 0.05% sodium pyruvate supported growth of 98% of the strains at 21% O2, compared to 75% with unsupplemented brucella broth. With both the supplemented agar and broth, growth responses occurred 1 to 2 days earlier than usual. Growth and aerotolerance of three strains of Campylobacter sputorum subsp. bubulus were not enhanced by the supplements.
Anisotropic photo-induced magnetism of a $Rb_j Co_k [Fe(CN)_6]_l \cdot n H_2 O$ thin film (2004)

A magneto-optically active thin film of Rb$_{j}$Co$_{k}$[Fe(CN)$_{6}$]$_{l}$ $\cdot$$n$H$_{2}$O has been prepared using a sequential assembly method. Upon irradiation with light and at 5 K, the net magnetization of the film increased when the surface of the film was oriented parallel to the external magnetic field of 0.1 T. However, when the surface of the film was perpendicular to the field, the net magnetization \emph{decreased} upon irradiation. The presence of dipolar fields and the low-dimensional nature of the system are used to describe the orientation dependence of the photo-induced magnetization. The ability to increase or decrease the photo-induced magnetization by changing the orientation of the system with respect to the field is a new phenomenon that may be useful in future device applications.
Supplementary Data from Proteasome Enzymatic Activities in Plasma as Risk Stratification of Patients with Acute Myeloid Leukemia and Advanced-Stage Myelodysplastic Syndrome (2023)

Supplementary Data from Proteasome Enzymatic Activities in Plasma as Risk Stratification of Patients with Acute Myeloid Leukemia and Advanced-Stage Myelodysplastic Syndrome
Splice sites of human papillomavirus type 16 E6 gene or heterologous gene required for transformation by E7 and accumulation of E7 RNA (1995)

Transformation of primary baby rat kidney cells by the human papillomavirus type 16 (HPV 16) E7 gene and efficient accumulation of E7 RNA have been shown by this laboratory to depend on the integrity of the nucleotide position (nt) 880 splice donor site. Here, the splice sites within the HPV 16 E6 open reading frame (ORF) and the sites of the SV40 splicing unit were examined for an ability to provide this requirement. Constructs containing the HPV 16 E6 sites and the SV40 splice site sequences were used for transformation and RNase protection assays. E6 splice sites supported a low level of transformation, in assays for complete HPV 16 early region constructs containing loss-of-function mutations of the nt 880 site. Using constructs with wild-type E6 or SV40 splice sites showed that both splice sites could substitute similarly for the requirement in cis of the nt 880 site for transformation. HPV 16 E6 mutated splice site and SV40 splice site in reverse, nonfunctional orientation relative to the promoter, were not transformation competent. The HPV 16 E7 RNA levels for the E6 splice site constructs correlated closely with the transformation frequency. The SV40 splice sites were required for E7 transcript accumulation. The results showed E6 splice site function and evidence for enhanced exon skipping from E6 splice donor site to acceptor sites 3' of the E7 ORF. This was shown with constructs containing loss-of-function mutations of the nt 880 site. These results confirmed the function of the splice sites by the transformation competent constructs and suggested lower transformation frequency than for wild type was due to skipping of the E7 exon. These patterns of transcripts may have a role in the regulation of gene expression during progression to malignancy. The combined results revealed that the general presence of a functional splice donor site was absolutely required for transformation by HPV 16 E7 and accumulation of E7 RNA.
Studies on the conformational flexibility of α-l-rhamnose-containing oligosaccharides using 13C-site-specific labeling, NMR spectroscopy and molecular simulations: implications for the three-dimensional structure of bacterial rhamnan polysaccharides (2012)

Bacterial polysaccharides are comprised of a variety of monosaccharides, L-rhamnose (6-deoxy-L-mannose) being one of them. This sugar is often part of α-(1 → 2)- and/or α-(1 → 3)-linkages and we have therefore studied the disaccharide α-L-Rhap-(1 → 2)-α-L-Rhap-OMe to obtain information on conformational preferences at this glycosidic linkage. The target disaccharide was synthesized with (13)C site-specific labeling at C1' and at C2', i.e., in the terminal group. 2D (1)H,(13)C-HSQC-HECADE and (1)H,(13)C-J-HMBC NMR experiments, 1D (13)C and (1)H NMR spectra together with total line-shape analysis were used to extract conformationally dependent hetero- and homonuclear spin-spin coupling constants. This resulted in the determination of (2)J(C2',H1'), (3)J(C1',C1), (3)J(C1',C3), (3)J(C2',C2), (2)J(C1',C2), (1)J(C1',C2'), and (1)J(C1',H1'). These data together with previously determined J(CH) and (1)H,(1)H NOEs result in fourteen conformationally dependent NMR parameters that are available for analysis of glycosidic linkage flexibility and conformational preferences. A 100 ns molecular dynamics (MD) simulation of the disaccharide with explicit water molecules as solvent showed a major conformational state at φ(H)≈ 40° and ψ(H)≈-35°, consistent with experimental NMR data. In addition, MD simulations were carried out also for α-L-Rhap-(1 → 3)-α-L-Rhap-OMe and a rhamnan hexasaccharide. The gathered information on the oligosaccharides was used to address conformational preferences for a larger structure, a 2- and 3-linked nonasaccharide, with implications for the 3D structure of rhamnan polysaccharides, which should be regarded as flexible polymers.
Volume effect of localized injection in functional MRI and electrophysiology (2013)

Sufficient time should be allowed for drug diffusion to ensure stable results, particularly for resting-state fMRI experiments.
Computational multiplex panel reduction to maximize information retention in breast cancer tissue microarrays (2022)

Recent state-of-the-art multiplex imaging techniques have expanded the depth of information that can be captured within a single tissue sample by allowing for panels with dozens of markers. Despite this increase in capacity, space on the panel is still limited due to technical artifacts, tissue loss, and long imaging acquisition time. As such, selecting which markers to include on a panel is important, since removing important markers will result in a loss of biologically relevant information, but identifying redundant markers will provide a room for other markers. To address this, we propose computational approaches to determine the amount of shared information between markers and select an optimally reduced panel that captures maximum amount of information with the fewest markers. Here we examine several panel selection approaches and evaluate them based on their ability to reconstruct the full panel images and information within breast cancer tissue microarray datasets using cyclic immunofluorescence as a proof of concept. We show that all methods perform adequately and can re-capture cell types using only 18 of 25 markers (72% of the original panel size). The correlation-based selection methods achieved the best single-cell marker mean intensity predictions with a Spearman correlation of 0.90 with the reduced panel. Using the proposed methods shown here, it is possible for researchers to design more efficient multiplex imaging panels that maximize the amount of information retained with the limited number of markers with respect to certain evaluation metrics and architecture biases.
Grafting polymers by enzymatic ring opening polymerisation—maximising the grafting efficiency (2008)

The synthesis of well-defined graft copolymers containing alkyl methacrylate, hydroxylalkyl methacrylate monomers and/or (poly(ethylene oxide) methacrylate macromonomers and their further graft chain extension with poly(ε-caprolactone) (PCL) was studied in both conventional solvents and supercritical carbon dioxide (scCO2). A cascade two-step synthetic approach was adopted in which copolymer backbones were prepared in a first stage via atom transfer radical polymerisation (ATRP). These copolymers take the form of methacrylate based polymer backbones. In one case hydroxyl groups are pendant and close to the backbone (poly(MMA-co-HEMA)) whilst in the second, the hydroxyl groups are present as the terminal group of a poly(ethylene oxide) graft arm significantly separated from the main backbone (poly(MMA-co-PEGMA)). In stage two, these hydroxyl moieties were then used as the initiation centre for further chain extension via enzymatic ring opening polymerisation (eROP). These studies were designed to prepare different poly(alkyl methacrylate) copolymers by ATRP to optimise the grafting efficiency of the enzymatic polymerisation. We previously reported a limited grafting level of up to 40% for the pendant hydroxyl groups of a poly(MMA-co-HEMA) copolymer system. This study demonstrated that higher grafting efficiency (up to 80%) could be obtained by using a highly randomized MMA-co-HEMA polymeric backbone. By contrast, 100% grafting was achieved by moving the hydroxyl groups away from the backbone when using the longer hydroxyl-terminated poly(ethylene oxide) methacrylate monomer (PEGMA) as a co-monomer in poly(MMA-co-PEGMA) backbones.
Role of Met Axis in Head and Neck Cancer (2013)

Head and neck cancer is the sixth most common type of cancer worldwide. Despite advances in aggressive multidisciplinary treatments, the 5-year survival rate for this dreadful disease is only 50%, mostly due to high rate of recurrence and early involvement of regional lymph nodes and subsequent metastasis. Understanding the molecular mechanisms responsible for invasion and metastasis is one of the most pressing goals in the field of head and neck cancer. Met, also known as hepatocyte growth factor receptor (HGFR), is a member of the receptor protein tyrosine kinase (RPTK) family. There is compelling evidence that Met axis is dysregulated and plays important roles in tumorigenesis, progression, metastasis, angiogenesis, and drug resistance in head and neck cancer. We describe in this review current understanding of Met axis in head and neck cancer biology and development of therapeutic inhibitors targeting Met axis.
Supplementary Table 2 from Heterogeneity and Cancer-Related Features in Lymphangioleiomyomatosis Cells and Tissue (2023)

&lt;p&gt;Table S2. A, Differentially expressed LAMp genes between non-LAM and LAM cells (FDR &lt; 5%; Guo dataset). B, Differential gene expression between LAM cells with low and high LAMcore values (all genes considered). C, Curated gene sets positively correlated (FDR &lt; 5%) with LAMcore in LAM cells. D, Curated gene sets negatively correlated (FDR &lt; 5%) with LAMcore in LAM cells. E, Curated gene sets positively correlated (FDR &lt; 5%) with LAMp in LAM cells. F, Curated gene sets negatively correlated (FDR &lt; 5%) with LAMp in LAM cells. G, Overexpressed genes (n = 50) in depicted six cancer cell lines and LAM cells, relative to all other cancer cell lines analyzed. H, Overrepresented GO terms and KEGG pathways in the 50 genes commonly overexpressed in the six cancer cell lines and LAM cells. I, Overrepresented transcription factor binding sites in LAMp and LAMcore signatures. J, Overrepresented GO terms and KEGG pathways (FDR &lt; 5%) in 10% of the most variably expressed genes among bulk LAM lung samples. K, Inferred immune cell contents in bulk LAM lung nodules (n = 14; GEO GSE12027) using CIBERSORTx.&lt;/p&gt;
La dihydropyrimidine déshydrogénase (DPD) (2014)

La dihydropyrimidine déshydrogénase (DPD) est l’enzyme clé du catabolisme de la famille des fluoropyrimidines. Son activité dans la population générale suit une courbe de Gauss, et elle est soumise à un polymorphisme génétique qui peut avoir des répercussions fonctionnelles, c’est-à-dire entraîner des déficits majeurs à l’origine de toxicité grave chez 2 à 5 % des patients traités. La sévérité de ces toxicités aiguës fait de leur prévention une priorité médicale et de santé publique. Différentes approches ont été évaluées, et la combinaison de deux techniques complémentaires, de génotypage et de phénotypage, nous apparaît indispensable pour la détection fiable d’un déficit en DPD en pratique courante et la prévention de toxicités sévères liées aux fluoropyrimidines.
Pharmacokinetics of cefaclor in renal failure: effects of multiple doses and hemodialysis (1982)

The pharmacokinetics of cefaclor were characterized in 15 functionally anephric patients on hemodialysis. Each patient received a 500-mg oral dose of cefaclor every 8 h for 10 days. Multiple serum drug levels were measured by bioassay on day 0 (no hemodialysis), day 10 during hemodialysis, and as single determinations 1 h after administration on days 1, 3, and 5. Analysis of cefaclor kinetics in these 15 patients along with kinetics from 24 previously studied patients showed that weight was the best single predictor of volume of distribution. The corrected creatinine clearance (calculated from serum creatinine, age, and sex) proved to be the best predictor of drug half-life (r = 0.969). Thus, a single serum creatinine test provided a better estimated of cefaclor half-life than a 24-h urine collection. Cefaclor was cleared with an average serum half-life of 2.9 h without hemodialysis and 1.5 h during hemodialysis. Cefaclor serum levels measured 1 h after administration on days 0, 1, 3, and 5 showed no evidence of accumulation. Thus, cefaclor may be administered orally in multiple doses without accumulation in functionally anephric patients. In patients on dialysis, dosage interval or quantity should be increased to compensate for doubled drug clearance dialysis.