gebhart/patrepeval huggingface dataset:
The Correlation between Size Reduction and the Mechanical Activation of Talc by a Multi-ring Media Mill. (1997)

The correlation between size reduction and mechanical activation in the wet grinding of talc was studied using a multi-ring media mill. The intensity of the compressive force exerted by the grinding rings of the mill was controlled by changing the material of the grinding rings, i. e., those made of tungsten carbide alloy (WC), stainless steel (SUS), partially stabilized zirconium oxide (ZrO2) and polyoxy methylene (POM). Products were characterized by median particle size, D, specific surface area, S, fractional amorphization and 50% dehydration temperature. Both size reduction and agglomeration were observed under high compressive force leading to a stationary state. The apparent rate of fractional amorphization was almost proportional to the increase in the compressive force. The decrease in 50% dehydration temperature changed linearly with the degree of apparent fractional amorphization.
2-Thiono-1,3-dioxol-4-ene (2001)

[37635-87-3] C3H2O2S (MW 102.12)





InChI = 1S/C3H2O2S/c6-3-4-1-2-5-3/h1-2H



InChIKey = MMGCXSBBWCOBEX-UHFFFAOYSA-N



(dienophile in Diels–Alder reactions;1 acetylene equivalent in cycloaddition reactions;2 source of ketene;3 forms dication dichalcogenides with strong Lewis acids4)



Alternate Name: vinylene thionocarbonate.



Physical Data: mp 48 °C; bp 60–70 °C/0.2 mmHg.



Solubility: sol acetonitrile, benzene, carbon tetrachloride, dichloromethane, toluene; insol hexane.



Form Supplied in: not commercially available.



Preparative Method: prepared by reaction of Phosphorus(V) Sulfide with Vinylene Carbonate.1



Purification: recrystallization from benzene–hexane gives white crystals; sublimation at 120 °C generates long white needles.



Handling, Storage, and Precautions: material is apparently stable.
Evaluation of epidermal growth factor receptor mutation status in serum DNA as a predictor of response to gefitinib (IRESSA) (2007)

The aim of this study was to evaluate the usefulness of EGFR mutation status in serum DNA as a means of predicting a benefit from gefitinib (IRESSA) therapy in Japanese patients with non-small cell lung cancer (NSCLC). We obtained pairs of tumour and serum samples from 42 patients treated with gefitinib. EGFR mutation status was determined by a direct sequencing method and by Scorpion Amplification Refractory Mutation System (ARMS) technology. EGFR mutations were detected in the tumour samples of eight patients and in the serum samples of seven patients. EGFR mutation status in the tumours and serum samples was consistent in 39 (92.9%) of the 42 pairs. EGFR mutations were strong correlations between both EGFR mutation status in the tumour samples and serum samples and objective response to gefitinib (P<0.001). Median progression-free survival time was significantly longer in the patients with EGFR mutations than in the patients without EGFR mutations (194 vs 55 days, P=0.016, in tumour samples; 174 vs 58 days, P=0.044, in serum samples). The results suggest that it is feasible to use serum DNA to detect EGFR mutation, and that it's potential as a predictor of response to, and survival on gefitinib is worthy of further evaluation.
Laser Architectures for Space-Based Sodium Resonance Fluorescence Lidar (2018)

NASA GSFC is developing a space-based sodium resonance fluorescence lidar for the International Space Station (ISS). We discuss the technology, prototypes, risks and trades for two laser architectures - Raman laser and sum frequency generation.
Individual Neuropeptides Regulate Gut‐Associated Lymphoid Tissue Integrity, Intestinal Immunoglobulin A Levels, and Respiratory Antibacterial Immunity (2000)

Supplementation of IV-TPN with CCK, gastrin, and NT prevents GALT atrophy, primarily in the distal bowel. Intestinal IgA levels improve but not to normal levels. CCK and gastrin reversed IV-TPN-induced effects on antibacterial pneumonia in immunized animals while NT did not.
Regimes of traction in concentrated contact lubrication (1981)

Experimental evidence is presented for the existence of three regimes of traction in concentrated contacts. Data are obtained in a rolling contact simulator by varying the lubricant, temperature, rolling speed, load and surface roughness at a fixed slide-to-roll ratio. At lower thicknesses the mixed regime is encountered, and traction is increased due to asperity interaction, while at higher film thicknesses, the lubricant pressure is distributed over a greater area than the Hertzian region, resulting in a lower average pressure and reduced traction.
New methodology for early-stage, microarchitecture-level power-performance analysis of microprocessors (2003)

The PowerTimer toolset has been developed for use in early-stage, microarchitecture-level power-performance analysis of microprocessors. The key component of the toolset is a parameterized set of energy functions that can be used in conjunction with any given cycle-accurate microarchitectural simulator. The energy functions model the power consumption of primitive and hierarchically composed building blocks which are used in microarchitecture-level performance models. Examples of structures modeled are pipeline stage latches, queues, buffers and component read/write multiplexers, local clock buffers, register files, and cache array macros. The energy functions can be derived using purely analytical equations that are driven by organizational, circuit, and technology parameters or behavioral equations that are derived from empirical, circuit-level simulation experiments. After describing the modeling methodology, we present analysis results in the context of a current-generation superscalar processor simulator to illustrate the use and effectiveness of such early-stage models. In addition to average power and performance tradeoff analysis, PowerTimer is useful in assessing the typical and worst-case power (or current) swings that occur between successive cycle windows in a given workload execution. Such a characterization of workloads at the early stage of microarchitecture definition helps pinpoint potential inductive noise problems on the voltage rail that can be addressed by designing an appropriate package or by suitably tuning the dynamic power management controls within the processor.
Abstract 986: High content analysis of 2D and 3D oncology models for target and phenotypic drug discovery (2019)

Charles River (CR) has developed many disease-relevant cellular models to screen small molecules and genetic modifiers for target and phenotypic based drug discovery. Our expertise and portfolio in bespoke oncology model development (e.g. patient derived xenografts) covers a wide variety of target classes such as inhibitors of cell cycle, cellular motility and migration and transcription factor translocation. Complex cellular models derived from primary cells, patient derived embryonic stem cells and induced pluripotent stem cells have been adapted for phenotypic screening. Models have been further developed to produce physiologically relevant multicellular structure co-cultures. Combining complex biological systems with multiparametric high content analysis provides detailed single cell quantification of cellular and subcellular biology. Such validated High Content assays can be applied to both target and phenotypic based drug-discovery platforms to support preclinical drug discovery and improve translation of targets and compounds to the clinic.Citation Format: Servane Lachize, Rhea van de Bospoort, Marta da Silva da Silva, Niki van der Steentraten, Ian Gowers, Roger Clark, Jeroen DeGroot, Ian Waddell, Hajo Schiewe, Shushant Jain. High content analysis of 2D and 3D oncology models for target and phenotypic drug discovery [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 986.
The RAG1 Homeodomain Recruits HMG1 and HMG2 To Facilitate Recombination Signal Sequence Binding and To Enhance the Intrinsic DNA-Bending Activity of RAG1-RAG2 (1999)

V(D)J recombination is initiated by the specific binding of the RAG1-RAG2 (RAG1/2) complex to the heptamer-nonamer recombination signal sequences (RSS). Several steps of the V(D)J recombination reaction can be reconstituted in vitro with only RAG1/2 plus the high-mobility-group protein HMG1 or HMG2. Here we show that the RAG1 homeodomain directly interacts with both HMG boxes of HMG1 and HMG2 (HMG1,2). This interaction facilitates the binding of RAG1/2 to the RSS, mainly by promoting high-affinity binding to the nonamer motif. Using circular-permutation assays, we found that the RAG1/2 complex bends the RSS DNA between the heptamer and nonamer motifs. HMG1,2 significantly enhance the binding and bending of the 23RSS but are not essential for the formation of a bent DNA intermediate on the 12RSS. A transient increase of HMG1,2 concentration in transfected cells increases the production of the final V(D)J recombinants in vivo.
Formation of Temporary Separating Walls in Microfluidic Devices (2008)

This work demonstrates a new mechanism for changing the architecture of microfluidic channels during device operation. This method uses an aqueous solution of a thermally responsive polymer (Pluronic), which undergoes reversible gel formation at elevated temperatures. This gelation temperature is lowered through the presence of sodium phosphate. A phase diagram for this material system is derived from rheometry experiments. Formation of a temporary gel wall in a microfluidic device occurs at the diffusive interface between a Pluronic solution and a sodium phosphate solution. The wall thickness increases along the channel, and it decreases at high flow rates. The wall thickness also increases with saline concentration. These observations are explained through scaling arguments for the diffusion problem and with the established phase diagram.
Regulatory Role of PlaR (YiaJ) for Plant Utilization in Escherichia coli K-12 (2019)

Outside a warm-blooded animal host, the enterobacterium Escherichia coli K-12 is also able to grow and survive in stressful nature. The major organic substance in nature is plant, but the genetic system of E. coli how to utilize plant-derived materials as nutrients is poorly understood. Here we describe the set of regulatory targets for uncharacterized IclR-family transcription factor YiaJ on the E. coli genome, using gSELEX screening system. Among a total of 18 high-affinity binding targets of YiaJ, the major regulatory target was identified to be the yiaLMNOPQRS operon for utilization of ascorbate from fruits and galacturonate from plant pectin. The targets of YiaJ also include the genes involved in the utilization for other plant-derived materials as nutrients such as fructose, sorbitol, glycerol and fructoselysine. Detailed in vitro and in vivo analyses suggest that L-ascorbate and α-D-galacturonate are the effector ligands for regulation of YiaJ function. These findings altogether indicate that YiaJ plays a major regulatory role in expression of a set of the genes for the utilization of plant-derived materials as nutrients for survival. PlaR was also suggested to play protecting roles of E. coli under stressful environments in nature, including the formation of biofilm. We then propose renaming YiaJ to PlaR (regulator of plant utilization). The natural hosts of enterobacterium Escherichia coli are warm-blooded animals, but even outside hosts, E. coli can survive even under stressful environments. On earth, the most common organic materials to be used as nutrients by E. coli are plant-derived components, but up to the present time, the genetic system of E. coli for plant utilization is poorly understand. In the course of gSELEX screening of the regulatory targets for hitherto uncharacterized TFs, we identified in this study the involvement of the IclR-family YiaJ in the regulation of about 20 genes or operons, of which the majority are related to the catabolism of plant-derived materials such as ascorbate, galacturonate, sorbitol, fructose and fructoselysine. Therefore, we propose to rename YiaJ to PlaR (regulator of plant utilization).
Detection of Adversarial Supports in Few-shot Classifiers Using Feature Preserving Autoencoders and Self-Similarity. (2020)

Few-shot classifiers excel under limited training samples, making it useful in real world applications. However, the advent of adversarial samples threatens the efficacy of such classifiers. For them to remain reliable, defences against such attacks must be explored. However, closer examination to prior literature reveals a big gap in this domain. Hence, in this work, we propose a detection strategy to highlight adversarial support sets, aiming to destroy a few-shot classifier's understanding of a certain class of objects. We make use of feature preserving autoencoder filtering and also the concept of self-similarity of a support set to perform this detection. As such, our method is attack-agnostic and also the first to explore detection for few-shot classifiers to the best of our knowledge. Our evaluation on the miniImagenet and CUB datasets exhibit optimism when employing our proposed approach, showing high AUROC scores for detection in general.
Comparison of linear and MLSE spatio-temporal interference rejection combining with an antenna array in a GSM system (2002)

By using multiple receiving antennas and spatial or spatio-temporal processing techniques cochannel interference (CCI) may be suppressed. The maximum likelihood (ML) estimator requires a spatio-temporal model of the CCI. The model may be inaccurate because of estimation errors or difficulties in the parametrization of the generally asynchronous CCI. In this case linear spatio-temporal filtering based on training or semi-blind algorithms can be competitive compared to the ML-based algorithms. This paper compares the performance of ML and linear spatio-temporal techniques in synchronous and asynchronous interference-limited GSM urban scenarios. The best results for the asynchronous CCI and/or propagation channels with fading are obtained with a linear spatio-temporal semi-blind filtering technique based on minimization of the dual least squares constant modulus criterion.
Simplifying Submission Requirements for the <i>Journal of Medicinal Chemistry</i> (2021)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTSimplifying Submission Requirements for the Journal of Medicinal ChemistryCraig W. LindsleyCraig W. LindsleyMore by Craig W. Lindsleyhttps://orcid.org/0000-0003-0168-1445, James BarrowJames BarrowMore by James Barrowhttps://orcid.org/0000-0001-5115-9300, Kelly ChibaleKelly ChibaleMore by Kelly Chibalehttps://orcid.org/0000-0002-1327-4727, Maria Laura BolognesiMaria Laura BolognesiMore by Maria Laura Bolognesihttps://orcid.org/0000-0002-1289-5361, Stuart ConwayStuart ConwayMore by Stuart Conwayhttps://orcid.org/0000-0002-5148-117X, William DennyWilliam DennyMore by William Dennyhttps://orcid.org/0000-0001-7997-1843, Ke DingKe DingMore by Ke Dinghttps://orcid.org/0000-0001-9016-812X, Stefan LauferStefan LauferMore by Stefan Lauferhttps://orcid.org/0000-0001-6952-1486, Luhua LaiLuhua LaiMore by Luhua Laihttps://orcid.org/0000-0002-8343-7587, Hong LiuHong LiuMore by Hong Liuhttps://orcid.org/0000-0003-3685-6268, Nouri NeamatiNouri NeamatiMore by Nouri Neamatihttps://orcid.org/0000-0003-3291-7131, Takayoshi SuzukiTakayoshi SuzukiMore by Takayoshi Suzukihttps://orcid.org/0000-0003-2439-879X, Nicholas MeanwellNicholas MeanwellMore by Nicholas Meanwellhttps://orcid.org/0000-0002-8857-1515, and Wendy YoungWendy YoungMore by Wendy Younghttps://orcid.org/0000-0001-9584-6233Cite this: J. Med. Chem. 2021, 64, 12, 7877–7878Publication Date (Web):June 15, 2021Publication History Published online15 June 2021Published inissue 24 June 2021https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00528https://doi.org/10.1021/acs.jmedchem.1c00528editorialACS PublicationsCopyright © 2021 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views8426Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (709 KB) Get e-AlertscloseSUBJECTS:Color,Computational modeling,Drug discovery,High-performance liquid chromatography,Medicinal chemistry Get e-Alerts
Digital Pre-shaping for Narrowband Filtering Impairment Compensation in Superchannel Applications (2013)

A digital time domain or frequency domain pre-shaping is proposed and demonstrated for combating narrowband filtering impairments in terabit “superchannel” applications, improving overall system performance.
Cytosolic malate dehydrogenase confers selectivity of the nucleic acid-conducting channel (2002)

We have described previously a cell surface channel that is highly selective for nucleic acids. Nucleic acid conductance is 10 pS and the channel is at least 10,000-fold more selective for oligodeoxynucleotides than any anion tested (1). Herein we provide evidence that the nucleic acid-conducting channel (NACh) is a heteromultimeric complex of at least two proteins; a 45-kDa pore-forming subunit (p45) and a 36-kDa regulatory subunit (p36). Reconstitution of p45 in planar lipid bilayers resulted in formation of a channel which gated in the absence of nucleic acid and which was more selective for anions (including oligonucleotide) than cations. This channel exhibited transitions from one level of current to another (or to the closed state); however the incidence of transitions was rare. Channel activity was not observed when p36 was reconstituted alone. Reconstitution of p36 with p45 restored nucleic acid dependence and selectivity to the channel. Protein sequence analysis identified p36 as cytosolic malate dehydrogenase (cMDH). Experiments were performed to prove that cMDH is a regulatory subunit of NACh. Selective activity was observed when p45 was reconstituted with pig heart cMDH but not with mitochondrial MDH. Both the enzyme substrate l-malate and antiserum raised against cMDH block NACh activity. These data demonstrate that a nucleic acid conducting channel is a complex of at least two proteins, p45 and cMDH. Furthermore, these data establish that cMDH confers nucleic acid selectivity of the channel.
Triazole-oligomers by 1,3-dipolar cycloaddition (2006)

A variety of triazole-oligomers have been prepared under microwave and conventional conditions from novel alkynes and azides.
Evaluation of crystalline quality of zirconium dioxide films on silicon by means of ion-beam channeling (1988)

Zirconium dioxide (ZrO2) films have been grown on Si(100) and Si(111) substrates at 800 °C by vacuum evaporation. A channeling spectrum of the Rutherford backscattering on the ZrO2 films shows that ZrO2 films [tetragonal (200)] are epitaxially grown on Si(100) substrate at 800 °C, which is consistent with x-ray diffraction and reflection high-energy electron diffraction observations. The spread of crystallite orientation in the epitaxial film is estimated to be 0.32°, by analyzing the angular dependence of the total backscattering yield.
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy (2014)

Guidelines on diagnosis and management of hypertrophic cardiomyopathy
ChemInform Abstract: Heterocyclic Carbenes. Part 5. N‐Heterocyclic Carbenes: Generation under Mild Conditions and Formation of Group 8‐10 Transition Metal Complexes Relevant to Catalysis. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Distributed dynamic resource allocation for multicell SDMA packet access networks (2004)

This paper addresses dynamic resource allocation (DRA) for the downlink of a SDMA broadband wireless packet network with multiple access ports and adaptive antennas. The main issue for distributed DRA is how to manage the intercell interference, which is very difficult to be handled in an uncoordinated environment, due to packet access and downlink beamforming. Here, we investigate the performance and the feasibility of some distributed DRA strategies to gain insight on the impact of the lack of coordination among cells. We propose to estimate the intercell interference on the basis of cell load and worst case (taking into account adaptive antennas) measured interference and implement some greedy strategies suitable for a distributed implementation. We show that the gap between random allocation (previously proposed for distributed packet allocation) and a centralized algorithm can be significantly reduced, although the implementation of an efficient distributed power control still appears a hard task.
Exploratory studies of the photochemistry of N-hydroxypyridine-2-thione esters. Generation of excited radicals by laser flash photolysis and in a conventional fluorescence spectrometer (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTExploratory studies of the photochemistry of N-hydroxypyridine-2-thione esters. Generation of excited radicals by laser flash photolysis and in a conventional fluorescence spectrometerC. Bohne, R. Boch, and J. C. ScaianoCite this: J. Org. Chem. 1990, 55, 19, 5414–5418Publication Date (Print):September 1, 1990Publication History Published online1 May 2002Published inissue 1 September 1990https://pubs.acs.org/doi/10.1021/jo00306a025https://doi.org/10.1021/jo00306a025research-articleACS PublicationsRequest reuse permissionsArticle Views221Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts