gebhart/patrepeval huggingface dataset:
Cutaneous sarcoidosis at sites of previous laser surgery. (2004)

A 33-year-old patient was referred for evaluation and treatment of enlarging scars in areas where full-face carbon dioxide (CO2) laser resurfacing had been performed previously. The patient denied any systemic illness and was in good health at the time of presentation. This is a case report of isolated sarcoidosis limited to the skin associated with CO2 laser resurfacing.
Overexpression of Periostin and Lumican in Esophageal Squamous Cell Carcinoma (2010)

To identify biomarkers for early detection for esophageal squamous cell carcinoma (ESCC), we previously carried out a genome-wide gene expression profiling study using an oligonucleotide microarray platform. This analysis led to identification of several transcripts that were significantly upregulated in ESCC compared to the adjacent normal epithelium. In the current study, we performed immunohistochemical analyses of protein products for two candidates genes identified from the DNA microarray analysis, periostin (POSTN) and lumican (LUM), using tissue microarrays. Increased expression of both periostin and lumican was observed in 100% of 137 different ESCC samples arrayed on tissue microarrays. Increased expression of periostin and lumican was observed in carcinoma as well as in stromal cell in the large majority of cases. These findings suggest that these candidates can be investigated in the sera of ESCC patients using ELISA or multiple reaction monitoring (MRM) type assays to further explore their utility as biomarkers.
Current Perspectives on Protective Roles of Erythropoietin in Cardiovascular System: Erythropoietin Receptor as a Novel Therapeutic Target (2012)

Erythropoietin (EPO) is a principal regulator that promotes proliferation and terminal differentiation of erythroid progenitor cells. EPO receptors are expressed not only in hematopoietic lineage cells but also in the cardiovascular system. We performed animal experiments using transgene-rescued EPO receptor null mutant mice (EpoR-/- rescued) that express the EPO receptor exclusively in the hematopoietic cells. The results of these experiments suggest that endogenous EPO/EPO receptor system in the heart exerts cardioprotective effects against myocardial injury induced by ischemia followed by reperfusion and pressure-overload induced left ventricular dysfunction. Many animal experiments have shown that the administration of recombinant human EPO also elicits cardioprotective effects against myocardial injury induced by ischemia and reperfusion. In contrast to the promising results of these animal experiments, recent clinical trials failed to demonstrate the reduction in infarct size or improvement of cardiac function by the administration of recombinant human EPO in patients with acute myocardial infarction who underwent primary percutaneous coronary intervention. It should be tested in future clinical studies whether a relatively low dose of recombinant human EPO or its derivatives that have no erythropoietic action reduces infarct size and ameliorates cardiac dysfunction in patients with acute myocardial infarction. In this article, we review implications of anemia associated with chronic heart failure, roles of the endogenous EPO/EPO receptor system, and the effects of the administration of erythropoiesis-stimulating agents in pathologic conditions of the heart by focusing on the EPO receptor as a potential candidate of novel therapeutic targets in cardiovascular diseases.
Technician Consistency in Specular Microscopy Measurements: A “Real-World” Retrospective Analysis of a United States Eye Bank (2017)

There was significant ECD variability associated with specular microscopy technicians and with the date of measurement. We recommend that eye banks collect data related to laboratory factors that have been shown to influence ECD variability.
Laparoscopia como método diagnóstico en pacientes con trauma abdominal, en un hospital de segundo nivel durante los años 2007-2017 (2017)

Introduccion: La lesion traumatica de los organos de la cavidadabdominal trae consigo una morbilidad y mortalidadelevada si no se sospecha, se evalua y se diagnostica demanera oportuna. Por lo tanto es indispensable realizar undiagnostico adecuado de lesiones de organos de la cavidadabdominal mediante el uso de metodos accesibles para latoma de decisiones en los pacientes. Por este motivo se evaluoel uso de la laparoscopia diagnostica en un hospital desegundo nivel.Materiales y metodos: Se realizo un estudio descriptivoy transversal en el Hospital Homero Castanier Crespo,Azogues-Ecuador. Se incluyeron 218 pacientes evaluadosmediante laparoscopia diagnostica y 44 pacientes medianteecografia FAST. Los datos obtenidos fueron evaluados en elprograma estadistico SPSS, version 15. Las variables cualitativasfueron representadas como frecuencias absolutas yrelativas (porcentaje).Resultados: La mayoria de los pacientes fueron del sexomasculino (grupo de laparoscopia diagnostica: 79,8%; n=174y grupo de ecografia FAST: 68,2%; n=30). La edad mas frecuentefue de 31 a 40 anos y la principal etiologia fueron losaccidentes de transito. La laparoscopia diagnostica dio unmayor numero de resultados positivos (74,8%) comparadoal grupo de ecografia FAST (54,5%). El tiempo de duraciondel metodo diagnostico fue menor en la laparoscopia dondeel 60,1% tuvo una duracion de 6-10 minutos; comparado ala ecografia FAST cuya duracion fue de 16-20 minutos en el52,3% de los pacientes.Conclusiones: La laparoscopia diagnostica ha sido propuestaen el trauma abdominal cerrado con resultados altamentesatisfactorios y prometedores, aun cuando no existeunanimidad para su uso como metodo rutinario, especialmenteen relacion al costo del procedimiento, sin embargo lalaparoscopia diagnostica es un procedimiento seguro, bientolerado que incluso se hace con anestesia local reduciendoal maximo los riesgos anestesicos.
A DNS Query including A Main Question with Accompanying Questions (2017)

This document enables DNS initiators to send a main question
accompanying with several related questions in a single DNS query, and
enables DNS responders to put the answers into a single DNS response.
This extension enables a range of initiators to look up X, or failing
that, Y in a better way than both current alternatives. This
mechanism can reduce the number of DNS round- trips per application
work-unit.
Design and implementation of a multivalued quantum circuit for threshold based color image segmentation (2018)

Color image segmentation is one of the very useful applications in the field of image processing at present. The main aim of this article is to deal with the application of quantum computation aspects to image processing task. The benefit of using quantum version of its corresponding classical imag e processing task is the speedup and efficiency. In this article, a circuit level implementation of the quantum multilevel threshold based color image segmentation technique is proposed and designed. Then the prospects of this technique are analyzed on some sample RGB color images. This article deals with the detailed design of quantum based multilevel color image segmentation circuit based on some predefined thresholds. The threshold based quantum circuit is built using the concepts of multivalued quantum parallelism, superposition and quantum oracle. This article also describes how the segmented image can be retrieved from quantum superposition states. Finally a detail comparison of the proposed modified technique with some well-known conventional techniques is discussed in this article.
ChemInform Abstract: Electronic and Chemical Properties of Ce<sub>0.8</sub>Zr<sub>0.2</sub>O<sub>2</sub>(III) Surfaces: Photoemission, XANES, Density‐Functional, and NO<sub>2</sub> Adsorption Studies. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
N-type silicon solar cell with rear tunnel oxide combined with rear screen-printed electrodes (2018)

In this article, we describe an n-type silicon solar cell with a conversion efficiency of 21.9% on a 156 mm pseudosquare Czochralski (Cz) wafer with a rear tunnel oxide-passivated structure and rear screen-printed electrodes. The thermal degradation of the rear structure during electrode firing was solved by adding a SiNx film on the rear surface. Not only the SiNx film but also the tunnel oxide structure was chemically etched using fire-through screen-printed electrodes, so that the electrodes contacted directly to the bulk silicon. A phosphorus-diffused layer appeared at the bulk silicon immediately below the tunnel oxide, and this shallowly and densely diffused layer reduced the contact resistivity between the electrodes and the bulk silicon layer. Degradation of rear passivation caused by etching on the tunnel oxide structure was improved by adding a diffused layer using POCl3 before chemical oxidation. The diffused layer using POCl3 was deep and had a low phosphorus concentration, thus the field effect worked successfully while Auger recombination was not enhanced.
Discovery of ( <i>R</i> )-9-Ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1- <i>a</i> ]isoindol- 6(2 <i>H</i> )-one, a Selective, Orally Active Agonist of the 5-HT <sub>2C</sub> Receptor (2007)

Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the synthesis and optimization of a new class of pyrazinoisoindolone-containing, selective 5-HT2C agonists as antiobesity agents. Key to optimization of the pyrazinoisoindolone core was the identification of the appropriate substitution pattern and functional groups which led to the discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one (58), a 5-HT2C agonist with >300-fold functional selectivity over 5-HT2B and >70-fold functional selectivity over 5-HT2A. Oral dosing of 58 reduced food intake in an acute rat feeding model, which could be completely reversed by a selective 5-HT2C antagonist and caused a reduction in body weight gain in a 4-day rat model.
Electrical motor design for hybrid heavy-duty electrical powertrain (2009)

The aim of this paper is to design the electric motorization of a hybrid powertrain applied to a heavy vehicle. A high electromagnetic torque is necessary to start up vehicle and to realize a boost working of the powertrain. The paper focuses on the surface-mounted permanent magnet (PM) synchronous drive design, including the design of the motor and the inverter. In order to achieve this design, an analytical model (AM) is used for the motor and a first machine has been obtained according to the specifications. The method makes it possible to optimize the electrical machine overall and then its integration in the power train. Then, finite element analyses (FEA) has been used to validate the results obtained through AM.
Effects of synchronization of laser induced fluorescence and corona induced fluorescence in a pulsed corona reactor (2005)

Corona-induced fluorescence (CIF) of nitric oxide (NO) reveals that NO(A/sup 2//spl Sigma//sup +/) is primarily excited through N/sub 2/(A/sup 3//spl Sigma//sub u//sup +/) produced in a pulsed corona rector (PCR). The charge voltage in PCR, the time delay of the high-voltage pulse applied to the reactor, and its time jitter vary from gas composition to gas composition. This is because the reactor electric equivalent resistance in an OFF state has different values for different gas components. The PCR pulse jitter, typically a few tenths of a microsecond, for the same gas composition, varies with the frequency of high-voltage pulses due to changes in feed composition. A precise time synchronization of CIF with the laser induced fluorescence (LIF), the intensified charge-coupled device (ICCD) detector and the PCR pulse reveals that NO molecules stay in the vibrational levels of the ground state for about 700 /spl mu/s.
Non-sequential optimization technique for a computer controlled optical surfacing process using multiple tool influence functions (2009)

Optical surfaces can be accurately figured by computer controlled optical surfacing (CCOS) that uses well characterized sub-diameter polishing tools driven by numerically controlled (NC) machines. The motion of the polishing tool is optimized to vary the dwell time of the polisher on the workpiece according to the desired removal and the calibrated tool influence function (TIF). Operating CCOS with small and very well characterized TIF achieves excellent performance, but it takes a long time. This overall polishing time can be reduced by performing sequential polishing runs that start with large tools and finish with smaller tools. In this paper we present a variation of this technique that uses a set of different size TIFs, but the optimization is performed globally - i.e. simultaneously optimizing the dwell times and tool shapes for the entire set of polishing runs. So the actual polishing runs will be sequential, but the optimization is comprehensive. As the optimization is modified from the classical method to the comprehensive non-sequential algorithm, the performance improvement is significant. For representative polishing runs we show figuring efficiency improvement from approximately 88% to approximately 98% in terms of residual RMS (root-mean-square) surface error and from approximately 47% to approximately 89% in terms of residual RMS slope error.
Evaluating the Assessment of Software Fault-Freeness (2014)

We propose to validate experimentally a theory of software certification that proceeds from assessment of confidence in fault-freeness (due to standards) to conservative prediction of failure-free operation.
Optimized packet classification for Software-Defined Networking (2014)

Recent trends, such as Software-Defined Networking (SDN), introduce programmability to the network with the opportunity to dynamically route traffic based on flow descriptions. Packet header lookup is the first phase in this process. In this paper, we illustrate improved header lookup and flow rule update speeds over conventional lookup algorithms. This is achieved by performing individual packet header field searches and combining the search results. We propose that individual algorithms should be selected for packet classification based on the application requirements. Improving the network processing performance with our configurable solution will directly support the proposed capability of programmability in SDN.
Light-induced Recovery of Effective Carrier Lifetime in Boron-doped Czochralski Silicon at Room Temperature (2016)

We report on the enhancements of effective carrier lifetime by light-induced "recovery" instead of "degradation" in oxygen-rich boron-doped Czochralski-grown silicon (Cz-Si) wafers at room temperature. The highest measured lifetime of τ=550 μs was obtained under light illumination at room temperature. We found that the increasing rate of the lifetimes depends on the firing condition and the illumination intensity. These dependencies are very similar to those of permanent recovery caused by hydrogenation of B-O defects or so called regeneration induced by illumination at higher temperatures. Therefore, it can be presumed that the significant increase of minority carrier lifetime is caused by hydrogenation of recombination active defects. However, the defect-inactive state is not stable and the lifetime was found to decrease slowly after the illuminated recovery step. The thermal activation energy of this defect reactivation reaction was obtained to be 0.36 eV from the Arrhenius plot, which is much smaller than that of the thermal dissociation of the hydrogenated B-O complex of 1.25 eV. This result indicates that the measured defect transitions are markedly different from those of B-O related defects. Possible mechanisms to control defect deactivation are discussed based on a given fractional concentration of charged hydrogen. By combining this deactivation process and a regeneration process, a very high lifetime value could be achieved in Cz-Si for solar cells.
Canaries in the Coal Mine: Nursing Home Dialysis Patients as Sentinels During COVID-19 (2020)

Background: At least one-third of USA COVID-19 deaths are skilled nursing facility (SNF) residents. Since 2016, Dialyze Direct has brought staff-assisted home hemodialysis (HD) on-site to more than 7,000 patients in SNFs. HD is performed 5x per week in a den setting. Since 3/9/20, Dialyze Direct has screened patients for COVID signs or symptoms before every HD. Infection controls include, but are not limited to, patient masks, staff PPE, physical distancing, and cohorting by COVID symptoms or status. The penetrance of likely COVID in SNF HD patients in NY vs FL is presented. Methods: A symptom diagnostic hierarchy tracked presumptive COVID infection and augmented the limited available COVID testing. At every HD, patient symptoms were recorded in an Electronic Health Record. Prevalent infection is defined as the proportion of patients with any of the symptoms during the pandemic living in the SNF during the week of interest. We report on weekly proportion from 3/9/20-5/16/20. Results: Once COVID symptoms appeared among the HD population, penetrance increased over time. In NY, penetrance in week 1,5 (4/5/20), and 10 was 8, 52, and 64%. In FL, comparable data was 13, 15, and 25%. Prevalence differences (5/10/20) for NY (29/45) vs FL (23/92) (RR 2.6, CI 1.7-3.9; p=.000). Conclusions: COVID symptom penetrance in SNF HD patients differed between NY and FL, likely attributable to differences in community disease prevalence, SNF’s infection controls, their relationships to referring hospitals, and state health regulatory environment. On 3/25/20, NY mandated SNFs to accept COVID hospital returns and forbade SNFs to demand proof of negative test before accepting the return of suspected patients. COVID symptoms in SNF HD residents can serve as sentinel for COVID for the general SNF population as they are the most intensively monitored patients there. The more frequent 5x per week HD model in the SNF provides intense and relevant local surveillance compared to less frequent conventional off-site HD. This sentinel strategy can inform an urgent pivot of infection containment efforts by the SNF and larger regulatory agents so that lessons learned from successful containment strategies can be implemented early. Funding: Commercial Support - Dialyze Direct
Disulfide Conjugation of Peptides to Oligonucleotides and Their Analogs (2006)

Peptide conjugation of oligonucleotides and their analogs is being studied widely towards improving the delivery of oligonucleotides into cells. Amongst the many possible routes of conjugation, the disulfide linkage has proved to be the most popular. This reversible linkage may have advantages for cell delivery, since it is likely to be cleaved within cells, thus releasing the oligonucleotide cargo. It is straightforward to introduce thiol functionalities into both oligonucleotide and peptide components suitable for disulfide conjugation. However, severe difficulties have been encountered in carrying out conjugations between highly cationic peptides and negatively charged oligonucleotides because of aggregation and precipitation. Presented here are reliable protocols for disulfide conjugation that have been verified for both cationic and hydrophobic peptides as well as oligonucleotides containing deoxyribonucleosides, ribonucleosides, 2'-O-methylribonucleosides, locked nucleic acid (LNA) units, as well as phosphorothioate backbones. Also presented are reliable protocols for disulfide conjugation of peptide nucleic acids (PNAs) with peptides.
Effects of Calcium Phosphate Nanoparticles on Ca-PO<sub>4</sub> Composite (2007)

Nano-particles of dicalcium phosphate anhydrous (DCPA) were synthesized for the first time. The objectives of this study were to incorporate DCPA nano-particles into resin for Ca-PO(4) release to combat dental caries, and to investigate the filler level effects. Nano-DCPA and nano-silica-fused silicon nitride whiskers at a 1:1 ratio were used at filler mass fractions of 0-75%. The flexural strengths in MPa (mean +/- SD; n = 6) of DCPA-whisker composites ranged from (106 +/- 39) at 0% fillers to (114 +/- 23) at 75% fillers, similar to (112 +/- 22) of a non-releasing composite (TPH) (p > 0.1). The composite with 75% fillers in a NaCl solution (133 mmol/L, pH = 7.4, 37 degrees C) yielded a Ca concentration of (0.65 +/- 0.02) mmol/L and PO(4) of (2.29 +/- 0.07) mmol/L. Relationships were established between ion-release and DCPA volume fraction V(DCPA): Ca = 4.46 V(DCPA)(1.6,) and = 66.9 V(DCPA)(2.6). Nano-DCPA-whisker PO(4) composites had high strength and released high levels of Ca-PO(4) requisite for remineralization. These new nano-composites could provide the needed combination of stress-bearing and caries-inhibiting capabilities.
Supplementary Figure Legends 1-3 from Microarray-Based Identification of &lt;i&gt;Tenascin C&lt;/i&gt; and &lt;i&gt;Tenascin XB&lt;/i&gt;, Genes Possibly Involved in Tumorigenesis Associated with Neurofibromatosis Type 1 (2023)

Supplementary Figure Legends 1-3 from Microarray-Based Identification of &lt;i&gt;Tenascin C&lt;/i&gt; and &lt;i&gt;Tenascin XB&lt;/i&gt;, Genes Possibly Involved in Tumorigenesis Associated with Neurofibromatosis Type 1
Crystal field analysis and Monte Carlo simulation of lattice disordering for Cm3+ in YPO4 and LuPO4 (2000)

A method of analyzing inhomogeneous line broadening with crystal-field theory is presented. For actinide ions with unfilled f-shells in solids, the most important contribution to line broadening of f-electron transitions is from short-range interactions with distorted lattice. Optically active curium ions are used to measure the degree of radiation damage in the vicinity of their lattice site. The radiation damage was produced by decay of distant 244Cm3+ ions. Fluorescence line narrowing (FLN) spectra show that inhomogeneous line broadening induced by α-decay of the actinide ion 244Cm3+ in single crystals of LuPO4 and YPO4 has a microscopic nature. Namely, correlation is absent between energy levels of the Cm3+ ions at different local environments. Monte Carlo simulation of lattice distortion and crystal-field calculation of Cm3+ energy levels have been conducted to provide a quantitative interpretation of the experimental results. This method should be applicable to 4f- and 3d-ions in crystalline materials with lattice distortion.
HVAC Noise Prediction Using Lighthill Wave Method (2023)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;Automotive Heating Ventilation and Air Conditioning (HVAC) system is essential in providing the thermal comfort to the cabin occupants. The HVAC noise which is typically not the main noise source in IC engine vehicles, is considered to be one of the dominant sources inside the electric vehicle cabin. As air is delivered through ducts and registers into the cabin, it will create an air-rush/broadband noise and in addition to that, any sharp edges or gaps in flow path can generate monotone/tonal noise. Noise emanating from the HVAC system can be reduced by optimizing the airflow path using virtual tools during the development stage. This paper mainly focuses on predicting the noise from the HVAC ducts and registers.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;In this study, noise simulations were carried-out with ducts and registers. A Finite Volume Method (FVM) based 3-dimensional (3D) Computational Fluid Dynamics (CFD) solver was used for flow as well as acoustic simulations. Large Eddy Simulation (LES) was used for flow field generation and noise characteristics were studied using a hybrid Lighthill Wave Model (LWM). The frequency response of the aeroacoustic noise from the ducts and registers were predicted using the simulations and the models were compared in terms of Overall Average Sound Pressure Level (OASPL). The simulated spectra exhibit good correlation with the test data.&lt;/div&gt;&lt;/div&gt;