gebhart/patrepeval huggingface dataset:
ADCC employing an NK cell line (haNK) expressing the high affinity CD16 allele with avelumab, an anti-PD-L1 antibody (2017)

NK-92 cells, and their derivative, designated aNK, were obtained from a patient with non-Hodgkin lymphoma. Prior clinical studies employing adoptively transferred irradiated aNK cells have provided evidence of clinical benefit and an acceptable safety profile. aNK cells have now been engineered to express IL-2 and the high affinity (ha) CD16 allele (designated haNK). Avelumab is a human IgG1 anti-PD-L1 monoclonal antibody, which has shown evidence of clinical activity in a range of human tumors. Prior in vitro studies have shown that avelumab has the ability to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) of human tumor cells when combined with NK cells. In the studies reported here, the ability of avelumab to enhance the lysis of a range of human carcinoma cells by irradiated haNK cells via the ADCC mechanism is demonstrated; this ADCC is shown to be inhibited by anti-CD16 blocking antibody and by concanamycin A, indicating the use of the granzyme/perforin pathway in tumor cell lysis. Studies also show that while NK cells have the ability to lyse aNK or haNK cells, the addition of NK cells to irradiated haNK cells does not inhibit haNK-mediated lysis of human tumor cells, with or without the addition of avelumab. Avelumab-mediated lysis of tumor cells by irradiated haNK cells is also shown to be similar to that of NK cells bearing the V/V Fc receptor high affinity allele. These studies thus provide the rationale for the clinical evaluation of the combined use of avelumab with that of irradiated adoptively transferred haNK cells.
Pattern Extraction In Sparse Representations With Application To Audio Coding (2009)

Publication in the conference proceedings of EUSIPCO, Glasgow, Scotland, 2009
Optical Coherence Tomography: an emerging technology for functional imaging in embryonic cardiovasculature (2007)

We have developed optical coherence tomography (OCT) for quantification of blood flow through the embryonic cardiovascular system. OCT is a non‐invasive technique capable of real‐time acquisition of high‐resolution (2–15μm), cross‐sectional images with up to 2mm depth of penetration. Doppler OCT is a functional extension of OCT that enables in vivo imaging of blood flow through heart and vasculature. We have developed spectral Doppler OCT velocimetry for localized quantification of temporal blood flow dynamics in the embryonic cardiovascular system. We present data demonstrating feasibility of this technique. Doppler OCT may provide a valuable tool for non‐invasively measuring blood flow in developing cardiovasculature.
Improving Radioimmonotargeting of Tumors: Variation in the Amount of L6 Mab Administered, Combined with an Immunoadsorption System (Ecia) (1993)

Extracorporeal immunoadsorption (ECIA) is a new method for the selective removal of circulating radiolabeled monoclonal antibodies (MAb) from plasma to increase the uptake in tumor versus normal tissues (T/N-ratio). To ascertain whether the amount of MAb affects T/N ratios immediately and 24 h after ECIA, we used a rat model with two tumor sites--one intramuscular (im) and one below the subrenal capsule (SR). Extracorporeal immunoadsorption was done with an avidin-agarose column after injection of 125I-labeled biotinylated L6 MAb. The animals received 10, 50 or 250 micrograms of L6 only (controls), or followed by ECIA. The efficacy of the procedure in removing plasma activity was 80-95%. For both tumor sites, the highest T/N-ratios were obtained with 10 micrograms L6. All T/N-ratios significantly improved for SR tumors by a factor ranging from 3.2 (lung) to 12.6 (bone marrow). The T/N-ratios were still elevated 24 h after ECIA. Injection of larger amounts of MAb, probably causing a higher degree of tumor saturation, will not necessarily improve the T/N ratio after ECIA.
EvanPhos: a ligand for ppm level Pd-catalyzed Suzuki–Miyaura couplings in either organic solvent or water (2018)

A new biaryl phosphine-containing platform can be constructed in only two steps and this complexes Pd(OAc)<sub>2</sub> forming a precursor of a very active catalyst useful for Suzuki–Miyaura cross-couplings of functionalized substrates.
WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies (2014)

WWOX was cloned as a putative tumor suppressor gene mapping to chromosomal fragile site FRA16D. Deletions affecting WWOX accompanied by loss of expression are frequent in various epithelial cancers. Translocations and deletions affecting WWOX are also common in multiple myeloma and are associated with worse prognosis. Metanalysis of gene expression datasets demonstrates that low WWOX expression is significantly associated with shorter relapse-free survival in ovarian and breast cancer patients. Although somatic mutations affecting WWOX are not frequent, analysis of TCGA tumor datasets led to identifying 44 novel mutations in various tumor types. The highest frequencies of mutations were found in head and neck cancers and uterine and gastric adenocarcinomas. Mouse models of gene ablation led us to conclude that Wwox does not behave as a highly penetrant, classical tumor suppressor gene since its deletion is not tumorigenic in most models and its role is more likely to be of relevance in tumor progression rather than in initiation. Analysis of signaling pathways associated with WWOX expression confirmed previous in vivo and in vitro observations linking WWOX function with the TGFβ/SMAD and WNT signaling pathways and with specific metabolic processes. Supporting these conclusions recently we demonstrated that indeed WWOX behaves as a modulator of TGFβ/SMAD signaling by binding and sequestering SMAD3 in the cytoplasmic compartment. As a consequence progressive loss of WWOX expression in advanced breast cancer would contribute to the pro-metastatic effects resulting from TGFβ/SMAD3 hyperactive signaling in breast cancer. Recently, GWAS and resequencing studies have linked the WWOX locus with familial dyslipidemias and metabolic syndrome related traits. Indeed, gene expression studies in liver conditional KO mice confirmed an association between WWOX expression and lipid metabolism. Finally, very recently the first human pedigrees with probands carrying homozygous germline loss of function WWOX mutations have been identified. These patients are characterized by severe CNS related pathology that includes epilepsy, ataxia and mental retardation. In summary, WWOX is a highly conserved and tightly regulated gene throughout evolution and when defective or deregulated the consequences are important and deleterious as demonstrated by its association not only with poor prognosis in cancer but also with other important human pathologies such as metabolic syndrome and CNS related pathologic conditions.
Radio Antenna Design for Sky-Averaged 21cm Cosmology Experiments: The REACH Case (2021)

Following the reported detection of an absorption profile associated with the 21[Formula: see text]cm sky-averaged signal from the Cosmic Dawn by the EDGES experiment in 2018, a number of experiments have been set up to verify this result. This paper discusses the design process used for global 21[Formula: see text]cm experiments, focusing specifically on the Radio Experiment for the Analysis of Cosmic Hydrogen (REACH). This experiment will seek to understand and compensate for systematic errors present using detailed modeling and characterization of the instrumentation. Detailed quantitative figures of merit and numerical modeling are used to assist the design process of the REACH dipole antenna (one of the two antenna designs for REACH Phase I). This design process produced a 2.5:1 frequency bandwidth dipole. The aim of this design was to balance spectral smoothness and low impedance reflections with the ability to describe and understand the antenna response to the sky signal to inform the critically important calibration during observation and data analysis.
Flexible Job-Shop Scheduling Method for Highly-Distributed Manufacturing Systems (2017)

Development in computer and network technologies is realizing highly-distributed manufacturing systems (HDMSs) where each facility is computerized and can communicate with each other. Distributed discrete event simulation taking advantage of this hardware environment has been discussed, and an algorithm for priority sequencing by communication among facilities was developed. This algorithm is also applicable to production scheduling with dispatching rules, and a distributed method of job-shop scheduling was proposed. This paper describes enhancement of this method for flexible job-shop where alternative machines exist. Mechanism for updating priority sequence for obtaining intermediate products is developed using that algorithm. Incorporating this mechanism enables application of the previous method to the flexible job-shop scheduling. Feasibility of the proposed method was shown by an example.
Vapor Sensing Using Waveguide-Based Multiple Surface Plasmon Resonance Sensors (2011)

Multiple surface plasmon resonance (SPR) sensors were prepared on a waveguide, and vapor sensing was carried out. A BK-7 slide glass was used as a waveguide core, and three pairs of Ag films (50 nm)/polymer films with various thicknesses were prepared separately on the waveguide. White light was input from the substrate edge, and the spectrum of the output light was observed. Discrete SPR dips can be observed in the output light spectra by selecting the dielectric constant and the thickness of the polymer film, which govern the SPR condition. The sensors with poly(vinyl alcohol) as sensing material were prepared and the water vapor sorption properties were investigated. Furthermore, polyisoprene, poly(vinyl carbazole), poly(methyl methacrylate), and perfluorinated polymer were used as sensing materials, and the detection of various vapors was carried out.
Nouvelle borne inférieure pour Pm/Ri/SumCi méthode NYCM (2004)

International audience
Non-linear identification on the digital magnetic recording channel (2002)

The authors describe a method for identifying the digital magnetic recording channel in which data dependent nonlinear effects are present. The method can be extended to any discrete-input, discrete-time channel with finite memory. The channel is considered as a finite state machine or lookup table, in which the number of states is related to the memory length of the channel. The model parameters are derived by using linear least-squares estimation or by adaptation of the model to minimize mean-squared error. A simple linear transformation is used to convert the finite state machine outputs to the coefficients of a Volterra series model. The results of the channel identification process are shown.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Impacts of Surface Roughness Reduction in (110) Si Substrates Fabricated by High-Temperature Annealing on Electron Mobility in n-Channel Metal–Oxide–Semiconductor Field-Effect Transistors on (110) Si (2013)

The effects of high-temperature Ar/H 2 annealing on (110) Si, which is known to provide flat (110) Si surfaces, have been studied from the viewpoint of metal–oxide–semiconductor (MOS) interface roughness and inversion-layer electron mobility limited by surface roughness scattering in (110) Si n-channel metal–oxide–semiconductor field-effect transistors (n-MOSFETs). It has been confirmed by quantitative transmission electron microscope (TEM) analysis that the reduction in the surface roughness on (110) Si is still maintained after gate oxidation with gate oxide thickness ( T ox ) of 6.9 nm. The mobility measurement of (110) Si n-MOSFETs fabricated using Si wafers with high-temperature Ar/H 2 annealing has revealed that the high-temperature annealing increases the electron mobility of (110) Si MOSFETs at 10 K by 14 and 5.7% for T ox values of 6.9 and 8.9 nm, respectively, and increases the electron mobility at 300 K by 2.5 and 0.72% for T ox values of 6.9 and 8.9 nm, respectively. The T ox dependence of the enhancement factor might be attributable to the increase in MOS interface roughness with increasing T ox . It has also been observed that the mobility enhancement factor is slightly dependent on the channel direction. The mobility increase has been observed to be greater along &lt;111&gt; than along &lt;112&gt;.
Time-resolved monitoring of nanocomposite growth using grazing incidence small-angle scattering (2008)

The success of structural science today is largely based on the use of X-ray diffraction on crystalline specimens. However, not all materials can be crystallized. This is especially true for membrane proteins and for larger multi-protein macromolecular assemblies. As the complexity of the biological systems being studied increases, their spatial dimensions also approach sub-micrometer scale which is on the borderline between what one can see directly with microscopic and imaging techniques and what can be studied using diffraction and scattering Coherent X-ray diffraction imaging technique has become an exciting field of research as it holds the potential for highresolution imaging of nonperiodic structures at diffraction-limited spatial resolution, without being limited by manufacturing defects of X-ray optics. In this talk we will provide an overview of the coherent diffraction imaging program at the APS. In particular, we present recent research and development on the concept of crystal guard aperture [2] as a way to eliminate parasitic-scattering backgrounds in coherent diffraction imaging experiments, which is crucial to achieving high signal-to-noise ratios at high diffraction resolution. We have applied this method to study metallic nanofoam formation in dealloying process. Recent experimental and phase-retrieval results will be presented.
Metabolism-Induced Toxicity of Selegiline and Carbamazepine Studied with an In Vitro Method (2008)

Carbamazepine and selegiline, although neuroprotective themselves, are presumed to have toxic metabolites. The aim of this study was to investigate the possible metabolism-induced toxicity of selegiline and carbamazepine with a novel in vit ro method: The drugs were incubated with target cells (neuroblastoma SH-SY5Y) with or without a preincubation with mouse or human hepatocytes. The viability of SH-SY5Y cells was then measured by using total cellular ATP as an indicator of the cell viability. For the pre-incubation with hepatocytes two different methods were used: Hepatocytes were grown either in multiwell plates (Model 1) or in filter inserts (Model 2). Selegiline itself increased SH-SY5Y viability, but the pre-incubation with both mouse and human hepatocytes made selegiline slightly toxic to SH-SY5Y cells. The biotransformation of carbamazepine seemed to be more complex and showed variation in different hepatocyte models. In general, human hepatocytes increased carbamazepine toxicity to SH-SY5Y cells, whereas mouse hepatocytes had no such effect. The methodology used (especially Model 1) could form a basis in developing a test system for a qualitative detection of metabolism-induced (neuro)toxicity in the early phase of drug discovery. In this respect, the present study might be promising for further evaluation by means of a larger number of independent experiments and different types of compounds.
Impact of Information on Network Performance - An Information-Theoretic Perspective (2009)

Available network information is an important factor in determining network performance. In this paper, we study the basic limits on the amount of network information that should be transmitted in the network to achieve a given level of network performance. From the perspective of information theory, network information is an information source, and the lower bound on network information is the minimum code letters required to encode the source. We propose a general information-theoretic framework, which can be applied to any network, to study the effect of network information on the performance of any network protocol. We also analyze the tradeoff between network performance improvement and network information collection overhead. To illustrate our approach, we use the framework to determine the lower bound on the traffic information for a simple scheduling protocol in wireless networks. The results in this paper may be used to analyze and evaluate network protocols and guide future designs.
Facilitation of Sexual Receptivity in the Female Rat by a Fragment of the LHRH Decapeptide, Ac-LHRH&lt;sup&gt;5-10&lt;/sup&gt; (1983)

The following fragments of LHRH were administered intraventricularly and tested for their ability to enhance sexual receptivity in ovariectomized, estrogen-primed female rats: LHRH1-6 NH2, Ac-LHRH5-10, des-Tyr5-LHRH and des-Gly10-LHRH. LHRH1-6 NH2 had no effect on sexual behavior compared to saline-infused controls. Ac-LHRH5-10, des-Tyr5 LHRH and des-Gly10-LHRH significantly elevated lordotic responding compared to saline-infused controls. The results suggest that the elements contained in the LHRH structure may be functionally differentiated and indicate that the active sequence for facilitation of mating behavior is contained in the last half of the LHRH molecule.
ApproxNet: Content and Contention Aware Video Analytics System for the Edge. (2019)

Videos take lot of time to transport over the network, hence running analytics on live video at the edge devices, right where it was captured has become an important system driver. However these edge devices, e.g., IoT devices, surveillance cameras, AR/VR gadgets are resource constrained. This makes it impossible to run state-of-the-art heavy Deep Neural Networks (DNNs) on them and yet provide low and stable latency under various circumstances, such as, changes in the resource availability on the device, the content characteristics, or requirements from the user. In this paper we introduce ApproxNet, a video analytics system for the edge. It enables novel dynamic approximation techniques to achieve desired inference latency and accuracy trade-off under different system conditions and resource contentions, variations in the complexity of the video contents and user requirements. It achieves this by enabling two approximation knobs within a single DNN model, rather than creating and maintaining an ensemble of models (such as in MCDNN [Mobisys-16]). Ensemble models run into memory issues on the lightweight devices and incur large switching penalties among the models in response to runtime changes. We show that ApproxNet can adapt seamlessly at runtime to video content changes and changes in system dynamics to provide low and stable latency for object detection on a video stream. We compare the accuracy and the latency to ResNet [2015], MCDNN, and MobileNets [Google-2017].
Sensorless Control of Dual Three-Phase Permanent Magnet Synchronous Machines—A Review (2023)

This paper presents an overview of various sensorless control methods, with a focus on dual three-phase permanent magnet synchronous machines (DTP-PMSM). Owing to the important role that DTP-PMSMs play in motion-control applications in industry, most academic researchers and industry activists seek to reduce costs and size while increasing the capability and efficiency of motion applications. This has led to an increase in the number of publications about multiphase machines in recent years. The purpose of this article is to review the most important sensorless control techniques, which are divided into two main categories, namely saliency-based control method for low-speed range and model-based control method for high-speed range. Both methods are subdivided into other categories, with a focus on DTP-PMSMs. The methods are compared with each other for the purpose of selecting the most suitable control technique for implementation in applications such as ship propulsion, wind turbines, and aerospace.
End-to-End Full-Page Handwriting Recognition (2018)

Despite decades of research, offline handwriting recognition (HWR) of historical documents remains a challenging problem, which if solved could greatly improve the searchability of online cultural heritage archives. Historical documents are plagued with noise, degradation, ink bleed-through, overlapping strokes, variation in slope and slant of the writing, and inconsistent layouts. Often the documents in a collection have been written by thousands of authors, all of whom have significantly different writing styles. In order to better capture the variations in writing styles we introduce a novel data augmentation technique. This methods achieves state-of-the-art results on modern datasets written in English and French and a historical dataset written in German.HWR models are often limited by the accuracy of the preceding steps of text detection and segmentation.Motivated by this, we present a deep learning model that jointly learns text detection, segmentation, and recognition using mostly images without detection or segmentation annotations.Our Start, Follow, Read (SFR) model is composed of a Region Proposal Network to find the start position of handwriting lines, a novel line follower network that incrementally follows and preprocesses lines of (perhaps curved) handwriting into dewarped images, and a CNN-LSTM network to read the characters. SFR exceeds the performance of the winner of the ICDAR2017 handwriting recognition competition, even when not using the provided competition region annotations.
Antimicrobial Effect of Medical Adhesive Composed of Aldehyded Dextran and ε-Poly(L-Lysine) (2011)

Infection of surgical wounds is a severe problem. Conventional tissue reattachment methods have limits of incomplete sealing and high susceptibility to infection. Medical adhesives have several advantages over traditional tissue reattachment techniques, but still have drawbacks, such as the probability of infection, low adhesive strength, and high cytotoxicity. Recently, a new medical adhesive (new-adhesive) with high adhesive strength and low cytotoxicity, composed of aldehyded dextran and ε-poly(L-lysine), was developed. The antimicrobial activity of the new-adhesive was assayed using agar media and porcine skin. In the agar diffusion method, inoculated microorganisms that contacted the new-adhesive were inactivated, but this was not dependent on the amount of new-adhesive. Similar to the agar media results, the topical antimicrobial effect of new-adhesive was confirmed using a porcine skin antimicrobial assay, and the effect was not due to physical blocking based on comparison with the group whose wounds were wrapped.
Development of Glycosylation Using the Glucopyranose 1,2-Orthobenzoate under Electrochemical Conditions (2013)

Substituted glucopyranose 1,2-orthobenzoate undergoes β-selective glycosylation. The developed orthobenzoate derivative was stable under standard workup conditions and efficiently provided a variety of glycosides by EGA (electrogenerated acid), produced by anodic oxidation of cyclohexanol. Upon comparison with Lewis and Brønsted acids, EGA superiorly affected activation of the orthoester to afford desired glycosides possessing such aglycons as sugars, steroids, and adamantanes.