gebhart/patrepeval huggingface dataset:
Computation of transient magneto-mechanical problems in electrical machines (2003)

This paper investigates numerical results relating to several aspects on noise and vibrations of electrical machinery. This is based upon the coupling between the magnetic field and the mechanical deformation in the stator. The coupling is typically considered by using reluctance forces. Since the deformations occurring are small compared to the machine's dimensions, there is no feedback to the magnetic system in numerical models. However, stator deformations are caused not only by reluctance forces, but also by magnetostriction effect of the stator iron. Magnetostriction is one of the main causes of noise in electromagnetic systems particularly when the flux density is above 1.5 T. In this paper, we show computational results of a transient numerical model developed earlier. This model incorporates the magnetostriction effect in addition to other electromechanical forces and related material interactions. Implementation results presented here for a 2-hp, surface mounted, permanent magnet motor. The results indicate that magnetostrictive forces are significant and must be accounted for in the electromagnetic system's design stage.
An extension of generalized bilinear transformation for digital redesign (2012)

In this paper, the existing digital redesign method, Generalized Bilinear Transformation (GBT), is extended so that large overshoot is suppressed while compar- atively large sampling period is obtained in the digital control system. The extension is established by introducing piecewise or multiple discretization parameters in GBT. Sev- eral simulation examples are given to show effectiveness of the proposed method. Keywords: Digital redesign, Generalized bilinear transformation (GBT), Sampling pe- riod, Discretization parameter, Switched system, 2-delay (N-delay) control
A recurrent SHANK3 frameshift variant in Autism Spectrum Disorder (2021)

Autism Spectrum Disorder (ASD) is genetically complex with ~100 copy number variants and genes involved. To try to establish more definitive genotype and phenotype correlations in ASD, we searched genome sequence data, and the literature, for recurrent predicted damaging sequence-level variants affecting single genes. We identified 18 individuals from 16 unrelated families carrying a heterozygous guanine duplication (c.3679dup; p.Ala1227Glyfs*69) occurring within a string of 8 guanines (genomic location [hg38]g.50,721,512dup) affecting SHANK3, a prototypical ASD gene (0.08% of ASD-affected individuals carried the predicted p.Ala1227Glyfs*69 frameshift variant). Most probands carried de novo mutations, but five individuals in three families inherited it through somatic mosaicism. We scrutinized the phenotype of p.Ala1227Glyfs*69 carriers, and while everyone (17/17) formally tested for ASD carried a diagnosis, there was the variable expression of core ASD features both within and between families. Defining such recurrent mutational mechanisms underlying an ASD outcome is important for genetic counseling and early intervention.
A Small Aromatic Compound Has Antifungal Properties and Potential Anti-Inflammatory Effects against Intestinal Inflammation (2019)

Resistance of the opportunistic pathogen Candida albicans to antifungal drugs has increased significantly in recent years. After screening 55 potential antifungal compounds from a chemical library, 2,3-dihydroxy-4-methoxybenzaldehyde (DHMB) was identified as having potential antifungal activity. The properties of DHMB were then assessed in vitro and in vivo against C. albicans overgrowth and intestinal inflammation. Substitution on the aromatic ring of DHMB led to a strong decrease in its biological activity against C. albicans. The MIC of DHMB was highly effective at eliminating C. albicans when compared to that of caspofungin or fluconazole. Additionally, DHMB was also effective against clinically isolated fluconazole- or caspofungin-resistant C. albicans strains. DHMB was administered to animals at high doses. This compound was not cytotoxic and was well-tolerated. In experimental dextran sodium sulphate (DSS)-induced colitis in mice, DHMB reduced the clinical and histological score of inflammation and promoted the elimination of C. albicans from the gut. This finding was supported by a decrease in aerobic bacteria while anaerobic bacteria populations were re-established in mice treated with DHMB. DHMB is a small organic molecule with antifungal properties and anti-inflammatory activity by exerting protective effects on intestinal epithelial cells.
Integration of tunable liquid crystal microcells on 1.55μm photodetector arrays using nanoimprint technology (2017)

International audience
Cardiac structural changes after transcatheter aortic valve replacement: systematic review and meta-analysis of cardiovascular magnetic resonance studies (2020)

CMR demonstrates reverse LV remodeling occurrs within 6-15 months after TAVR, with reductions in LVEDVi, LVESVi and LVMi, and increased LVEF.
Structural library and visualization of endogenously oxidized phosphatidylcholines using mass spectrometry-based techniques (2021)

Although oxidized phosphatidylcholines (oxPCs) play critical roles in numerous pathological events, the type and production sites of endogenous oxPCs remain unknown because of the lack of structural information and dedicated analytical methods. Herein, a library of 465 oxPCs is constructed using high-resolution mass spectrometry-based non-targeted analytical methods and employed to detect 70 oxPCs in mice with acetaminophen-induced acute liver failure. We show that doubly oxygenated polyunsaturated fatty acid (PUFA)-PCs (PC PUFA;O2), containing epoxy and hydroxide groups, are generated in the early phase of liver injury. Hybridization with in-vivo <sup>18</sup>O labeling and matrix-assisted laser desorption/ionization-tandem MS imaging reveals that PC PUFA;O2 are accumulated in cytochrome P450 2E1-expressing and glutathione-depleted hepatocytes, which are the major sites of liver injury. The developed library and visualization methodology should facilitate the characterization of specific lipid peroxidation events and enhance our understanding of their physiological and pathological significance in lipid peroxidation-related diseases.
Synthesis and Reactions of Cyclic Silylboranes. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Small‐Molecule Planar‐Mixed Heterojunction Photovoltaic Cells with Fullerene‐Based Electron Filtering Buffers (2013)

An electron filtering buffer with high electron mobility and efficient exciton-blocking is employed in a hybrid planar-mixed heterojunction solar cell. The novel buffer can significantly reduce bimolecular recombination and exciton-polaron quenching, leading to a small-molecule photovoltaic cell with a power conversion efficiency of 8.1% ± 0.4% under 1 sun illumination.
Multiplex spatial systems analysis of local nanodose drug responses predicts effective treatment combinations of immunotherapies and targeted agents in mammary carcinoma (2021)

SUMMARY Better methods are needed to identify effective combinations of immunotherapies with chemotherapies and targeted anti-cancer agents. Here we present a Multiplex Implantable Microdevice Assay (MIMA) system for rapid in vivo assessment of the effects of multiple, spatially separate anticancer drugs directly in the complex tumor microenvironment. In prototypic experiments, olaparib, lenvatinib, palbociclib, venetoclax, panobinostat, doxorubicin, and paclitaxel and combinations thereof were administered simultaneously to murine mammary tumor models. Quantitative multiplex immunohistochemistry and spatial systems analyses of each local drug response defined cellular relations of fibroblasts, endothelial cells, immune lineages, immunogenic cell death, tumor proliferation and/or cancer stem cells that were used to predict effective drug combinations. A predicted combination of panobinostat, venetoclax and anti-CD40 showed long-term anti-tumor efficacy in multiple mouse models with no observable toxicity when administered systemically. Future MIMA use promises to design effective drug combinations for tumor cell control and immune activation on a personalized basis.
Automated Transit Fleet Electrification Planning in Response to Route Dynamics, Vehicle Utilization, and Local Climate (2021)

Transit electrification is difficult, requiring the consideration of many factors including route dynamics, vehicle utilization, and local ambient temperatures. Incumbent planning tools typically rely upon static vehicle efficiency numbers which do not consider local factors specific to each fleet. This paper summarizes a collaboration between NREL and Microgrid Labs, which produced an automated sizing tool capable of producing vehicle battery and motor sizing for drop-in electrification. Furthermore, the workflow also exports the electric-vehicle supply equipment needed to support fleet electrification. The paper summarizes the model theory and includes a sample pilot study performed in support of the Via Mobility transit fleet.
A Computer Model of Flamelet Distribution on the Burning Surface of a Composite Solid Propellant (2000)

The paper attempts to obtain an approximate distribution of oxidizer/fuel (O/F) flamelets on the burning surface of a composite solid propellant, mainly of the ammonium perchlorate (AP)-hydrocarbon (HC) binder variety commonly used in rocket propulsion applications today. A computer model is developed to simulate the random packing of oxidizer particles of different size distributions in the propellant. The focus of the present work is on the distinction between pockets of fine AP particles amidst the binder that may bum in a premixed O/F flame and the sufficiently large AP particles that bum with the surrounding vapor flow in an attached diffusion flame. A transition occurs between premixed burning and attached diffusion flamelet-burning over each oxidizer particle as the ambient pressure is varied. A simple criterion evolved earlier to delineate the two regimes of burning in the particle size-pressure domain has been employed to determine the flamelet type that prevails over each exposed particle of the model propellant at a given pressure. Delaunay triangulation is adopted to deal with regions of fine AP-binder corresponding to premixed burning. The results are compared with previously reported experimental observations of burning rate for specific propellant formulations that exhibited distinct jumps in their burning rate with variation in pressure. It was argued that the burning rate jumps corresponded to a concerted shift in the burning regime of a majority of fine particles. The present simulation supports this argument.
One-Year Treatment with Olanzapine Depot in Female Rats: Metabolic Effects (2019)

Our data show that the continuous increase in body weight in response to long-term olanzapine exposure was accompanied by surprisingly few concomitant changes in plasma lipids and lipogenic gene expression, suggesting that adaptive mechanisms are involved to reduce long-term metabolic adverse effects of this antipsychotic agent in rats.
Electron spin resonance evidence that E'/sub /spl gamma// centers can behave as switching oxide traps (1995)

We provide direct and unambiguous experimental spectroscopic evidence for the structure of a switching oxide tap in thermally grown SiO/sub 2/ gate oxides on Si. Switching oxide traps can "switch" charge state in response to changes in the voltage applied to the gate of a metal-oxide-semiconductor field-effect-transistor. Electron spin resonance measurements reveal that some E'/sub /spl gamma// centers (a hole trapped at an oxygen vacancy) can behave as switching oxide traps.
Pachydermatous eosinophilic dermatitis (1996)

We report three South African black teenage girls with extensive pruritic papular lesions arising on a pachydermatous base, resembling severe atopic dermatitis or onchodermatitis. All three had peculiar hypertrophic genital lesions and peripheral blood eosinophilia. Histological studies showed an eosinophil-rich lymphohistiocytic infiltrate and variable fibrosis. Extensive fibrillar extracellular deposition of eosinophil granule major basic protein was demonstrated by an indirect immunofluorescence technique. A beneficial therapeutic effect was obtained using dapsone, prednisolone and cetirizine. The term pachydermatous eosinophilic dermatitis is proposed and its position among other conditions characterized by peripheral blood and skin tissue eosinophilia, is discussed.
Testis-specific transcription mechanisms promoting male germ-cell differentiation (2004)

Male germ-cell differentiation requires spermatogenic stage- and cell-specific gene expression that is achieved by unique chromatin remodeling, transcriptional control and the expression of testis-specific genes or isoforms. Recent findings have shown that the testis has specialized transcription complexes that coordinate the differentiation program of spermatogenesis. There are male germ cell-specific differences in the components of the general transcription machinery. These include upregulated expression of the TATA-binding protein (TBP) family and its associated cofactors. Importantly, a member of the TBP family, TBP-like factor (TLF), has a distribution pattern that is dependent on the spermatogenic cycle and is essential for spermatogenesis. Interestingly TBP-associated factor (TAF7), a factor of the transcription factor (TF)IID complex, is exchanged at a critical stage in germ cell development for the testis-specific paralogue TAF7L. A compelling amount of data has established that cAMP-response-element modulator (CREM), a transcription factor responsive to the cAMP signal transduction pathway, drives expression of key testis-specific genes. In this review we summarize recent advances in the transcription machinery that is testis-specific, gene-selective and necessary for the process of spermatogenesis.
Combined Raman Scattering and TEM Studies on Polytype Transformation in SiC from Heavily Nitrogen Doping (2010)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation J. Chen, S. C. Lien, Z. C. Feng, C. H. Kuan, R.‐H. Horng, J. H. Zhao, W. Lu; Combined Raman Scattering and TEM Studies on Polytype Transformation in SiC from Heavily Nitrogen Doping. AIP Conference Proceedings 6 August 2010; 1267 (1): 1139–1140. https://doi.org/10.1063/1.3482344 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Role of Hydrogen Bonding in Azobenzene–Urea Assemblies. Structural Evaluations of Multilayers on Solid Substrates (2003)

Abstract The multilayers of three homologous azobenzene (Az)-containing urea derivatives, having two, one and no hydrogen atom(s) at the terminal nitrogen atom in the urea moiety, and a simple long chain urea (hexadecylurea) were prepared by the Langmuir–Schaefer method. X-ray reflectometry, contact angle measurements of water, and Fourier transform infrared (FTIR) spectroscopy were undertaken to evaluate the layer structure and properties of these multilayered films. Of the four compounds, only the Az amphiphile, having no hydrogen atom at the terminus nitrogen atom, provided a different type of multilayers in terms of the molecular orientation, flexibility of the packing state, and characteristics of the intermolecular hydrogen bonding. The obtained data strongly support the formation of bifurcated hydrogen bonds for compounds having one or two hydrogen atom(s) at the terminus nitrogen of urea. The aspects obtained in this structural study can be exactly correlated with the properties of the Langmuir monolayers floating on water (Seki et al., Langmuir, 18, 5462 (2002).). Based on the X-ray and IR spectroscopic data, plausible models of the packed structure of the urea compounds in the multilayers are proposed.
Interferon gamma production by peripheral blood lymphocytes to hepatitis C virus core protein in chronic hepatitis C infection (1995)

Evidence suggests that cellular immunity to hepatitis C virus (HCV) core protein may be important in the pathogenesis of viral infection. Therefore, interferon gamma (IFN-gamma) production by peripheral blood mononuclear cells (PBMC) derived from patients with chronic HCV infection (genotype 1b) was examined. The cellular immune response was evaluated with a recombinant HCV core fusion protein derived from a patient with genotype 1b. To identify the immunodominant epitopes, IFN-gamma production in responders was also assessed with a panel of nine synthetic peptides that covered the entire core region. It was found that mononuclear cells from 24 (52%) of 46 patients with chronic liver disease responded to the core protein; asymptomatic HCV carriers demonstrated a lower response rate (14%, P < .05). More important, individuals who had received IFN-alpha treatment and went into clinical and virological remission had a higher response rate (75%, P < .05) compared with those with ongoing hepatitis whose treatment failed (31%). Of 25 patients whose mononuclear cells responded to HCV core protein, 18 had a significant response to one or more peptides; 12 patients reacted to a peptide mixture containing hydrophilic sequences. The core peptide amino acid sequence 141 to 160 was recognized in 9 patients. Interestingly, 7 of 8 patients bearing HLA DR 4 and w53 haplotypes recognized the peptide sequence 141 to 160. Thus, IFN-gamma production of the mononuclear cell response appeared to be HLA DR restricted, and the responding cells were identified as CD4+ T cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies (2015)

The advent of super-resolution microscopy (nanoscopy) has set high standards for fluorescence tagging. Fluorescent proteins (FPs) are convenient tags in conventional imaging, but their use in nanoscopy has been questioned due to their relatively large size and propensity to form multimers. Here, we compared the nanoscale organization of proteins with or without FP tags by introducing the unnatural amino acid propargyl-L-lysine (PRK) in 26 proteins known to form multimolecular arrangements and into their FP-tagged variants. We revealed the proteins by coupling synthetic fluorophores to PRK via click chemistry and visualized them using ground-state depletion microscopy followed by individual molecule return, as well as stimulated emission depletion microscopy. The arrangements formed by the FP-tagged and nontagged proteins were similar. Mild, but statistically significant differences were observed for only six proteins (23% of all proteins tested). This suggests that FP-based nanoscopy is generally reliable. Unnatural amino acids should be a reliable alternative for the few proteins that are sensitive to FP tagging.
Activity and stability of soluble and immobilized α-glucosidase from baker's yeast in cosolvent systems (2006)

The activity of α-glucosidase from baker's yeast was determined in various concentrations of dioxan, tetrahydrofuran, tert-butanol, dimethylformamide, methanol and dimethylsulfoxide (DMSO). Higher activities were observed with sucrose than with nitrophenylglucoside as substrate in cosolvent mixtures. In 30% (v/v) DMSO, 25% of the activity obtained in pure water was detected, and in 30% (v/v) methanol 12.5% of the activity in pure water was detected, while in other cosolvents there was almost no activity under these conditions. α-glucosidase was immobilized onto a macroporous copolymer of ethylene glycol dimethacrylate and glycidyl methacrylate, poly(GMA-co-EGDMA), by the glutaraldehyde method. By immobilization, the half-life of the enzyme in 35% (v/v) methanol was increased from 6 to 60 min and from 4 to 15 min in 45% (v/v) DMSO. The activity of the immobilized enzyme in 30% (v/v) DMSO and 30% (v/v) methanol was 22% and 18% of the activity in pure water, respectively.
Fuse: A Technique to Anticipate Failures due to Degradation in ALUs (2007)

This paper proposes the fuse, a technique to anticipate failures due to degradation in any ALU (arithmetic logic unit), and particularly in an adder. The fuse consists of a replica of the weakest transistor in the adder and the circuitry required to measure its degradation. By mimicking the behavior of the replicated transistor the fuse anticipates the failure short before the first failure in the adder appears, and hence, data corruption and program crashes can be avoided. Our results show that the fuse anticipates the failure in more than 99.9% of the cases after 96.6% of the lifetime, even for pessimistic random within-die variations.
Variable-Tilt Helicopter Rotor Mast (1995)

Variable-tilt helicopter rotor mast proposed to improve helicopter performance and reduce vibration, especially at upper end of forward-speed range of helicopters. Achieved by use of universal coupling in main rotor mast or by tilting entire engine-and-transmission platform. Performance, energy efficiency, and safety enhanced.
ChemInform Abstract: Bakers′ Yeast Oxidation of Methyl para‐Tolylsulfide: Synthesis of a Chiral Intermediate in the Preparation of the Mevinic Acid‐Type Hypocholestemic Agents. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
MicroRNA-223 protects neurons from degeneration in Experimental Autoimmune Encephalomyelitis (2018)

Abstract Multiple sclerosis (MS) is an autoimmune disease characterized by demyelination and neurodegeneration in the brain, spinal cord and optic nerve. Neuronal degeneration and death underlie progressive forms of MS and cognitive dysfunction. Neuronal damage is triggered by numerous harmful factors in the brain that engage diverse signalling cascades in neurons thus therapeutic approaches to protect neurons will need to focus on agents that can target broad biological processes. To target the broad spectrum of signaling events that mediate neurodegeneration in MS we have focused on non-coding small microRNAs (miRNAs). microRNAs are epigenetic regulators of protein expression, targeting messenger RNAs (mRNAs) and inhibiting their translation. Dysregulation of miRNAs has been described in many neurodegenerative diseases including MS. In this study we identified two miRNAs, miR-223-3p and miR-27a-3p, that were upregulated in neurons in the experimental autoimmune encephalomyelitis (EAE) mouse model of CNS inflammation and in active MS lesions. Overexpression of miR-27a-3p or miR-223-3p protected dissociated cortical neurons from degeneration in response to peripheral blood mononuclear cell conditioned media (PBMC-CM). Introduction of miR-223-3p in vivo in mouse retinal ganglion cells (RGCs) protected RGC axons from degeneration in the EAE model. By in silico analysis we found that mRNAs in the glutamate receptor (GluR) pathway are enriched in miR-27a-3p and miR-223-3p targets. Antagonism of the GluR pathway protected neurons from PBMC-CM-dependent degeneration. Our results suggest that miR-223-3p and miR-27a-3p are upregulated in response to inflammation to mediate a compensatory neuroprotective gene expression program that desensitizes neurons to glutamate by downregulating mRNAs involved in GluR signalling.