gebhart/patrepeval huggingface dataset:
Immunotherapy of Myelodysplastic Syndrome: You Can Run, but You Can't Hide (2017)

The hypomethylating agent decitabine induces expression of the cancer/testis antigen NY-ESO-1 in the myeloid cells of patients with myelodysplastic syndrome (MDS). Patients with MDS treated with decitabine and an NY-ESO-1 vaccine developed NY-ESO-1-specific T-cell responses directed against their abnormal myeloid cells, raising hopes for combinatorial immunotherapy of this disease. <i>Clin Cancer Res; 24(5); 991-3. ©2017 AACR</i><i>See related article by Griffiths et al., p. 1019</i>.
Analysis of gene expression profiles in human HL‐60 cell exposed to cantharidin using cDNA microarray (2003)

Cantharidin is a natural toxin that has antitumor properties and causes leukocytosis as well as increasing sensitivity of tumor cells resistant to other chemotherapeutic agents. There is limited information, however, on the molecular pharmacological mechanisms of cantharidin on human cancer cells. We have used cDNA microarrays to identify gene expression changes in HL-60 promyeloid leukemia cells exposed to cantharidin. Cantharidin-treated cells not only decreased expression of genes coding for proteins involved in DNA replication (e.g., DNA polymerase delta), DNA repair (e.g., FANCG, ERCC), energy metabolism (e.g., isocitrate dehydrogenase alpha, ADP/ATP translocase), but also decreased expression of genes coding for proteins that have oncogenic activity (e.g., c-myc, GTPase) or show tumor-specific expression (e.g., phosphatidylinositol 3-kinase). In contrast, these treated cells overexpressed several genes that encode intracellular and secreted growth-inhibitory proteins (e.g., BTG2, MCP-3) as well as proapoptotic genes (e.g., ATL-derived PMA-responsive peptide). Our findings suggest that alterations in specific genes functionally related to cell proliferation or apoptosis may be responsible for cantharidin-mediated cytotoxicity. We also found that exposure of HL-60 cells to cantharidin resulted in the decreased expression of multidrug resistance-associated protein genes (e.g., ABCA3, MOAT-B), suggesting that cantharidin may be used as an oncotherapy sensitizer, and the increased expression of genes in modulating cytokine production and inflammatory response (e.g., NFIL-3, N-formylpeptide receptor), which may partly explain the stimulating effects on leukocytosis. Our data provide new insight into the molecular mechanisms of cantharidin.
Accumulation and Oriented Transport of Ampicillin in Caco-2 Cells from Its Pivaloyloxymethylester Prodrug, Pivampicillin (2005)

Pivampicillin (PIVA), an acyloxymethylester of ampicillin, is thought to enhance the oral bioavailability of ampicillin because of its greater lipophilicity compared to that of ampicillin. The fate of PIVA in intestinal cells and the exact location of its conversion into ampicillin have, however, never been unambiguously established. Polarized Caco-2 cells have been used to examine the handling of PIVA and the release of ampicillin from PIVA by the intestinal epithelium. Experiments were limited to 3 h. Cells incubated with PIVA (apical pole) showed a fast accumulation of ampicillin and transport toward the basolateral medium, whereas PIVA itself was only poorly accumulated and transported. Cells incubated with free ampicillin accumulated and transported only minimal amounts of this drug. Release of ampicillin from cells incubated with PIVA was unaffected by PEPT1 and OCTN2 inhibitors but was sharply decreased after ATP depletion or addition of bis(4-nitrophenyl)-phosphate (BNPP; an esterase inhibitor). PIVA incubated with Caco-2 lysates released free ampicillin, and this release was inhibited by BNPP. Efflux studies showed that the ampicillin that accumulated in cells after incubation with PIVA was preferentially transported out of the cells through the basolateral pole. This efflux was decreased by multidrug resistance-associated protein (MRP) inhibitors (probenecid, MK-571) and by ATP depletion. A phthalimidomethylester of ampicillin that resists cellular esterases failed to cause any significant release (cell lysate) or transport (polarized Caco-2 cells) of ampicillin. These results show that when PIVA is given to Caco-2 cells from their apical pole, ampicillin is released intracellularly and that ampicillin is thereafter preferentially effluxed into the basolateral medium through an MRP-like transporter.
Carbon‐ion beam treatment induces systemic antitumor immunity against murine squamous cell carcinoma (2010)

To the authors' knowledge, this is the first demonstration of strong antitumor immunity induced by CIB treatment in a dermal tumor, and this effect was enhanced by combining it with DC-based immunotherapy. The authors concluded that this combination warrants further investigation as a promising modality for the prevention of tumor recurrence.
Appendix 5: Description of Classes of an IP VPN Information Model (2008)

This appendix contains sections titled: Introduction Policy Class Definitions
Phase measurement and calibration characteristics of optically controlled phased array antenna using multiple SMFs (2010)

Microwave/millimeter-wave phase and amplitude characteristics using the optically controlled phased array antenna with a single SMF have ever been obtained. In this presentation, we propose the optically controlled phased array antenna with different SMFs for each antenna element. Ideal phases for the beam steering can be obtained by the adjustment of the LD wavelength suitably. First, phase characteristics of the array using multiple SMFs were compared with that with a single SMF. Second, we verify that ideal phase characteristics can be experimentally obtained by the adjustment of LD wavelength. Excellent phase characteristics using 2-element optically controlled array were experimentally demonstrated with calibration measurement of the phases.
Supplementary Figure Legends 1-3, Movie Legends1-5 from Ki-67 as a Molecular Target for Therapy in an &lt;i&gt;In vitro&lt;/i&gt; Three-Dimensional Model for Ovarian Cancer (2023)

Supplementary Figure Legends 1-3, Movie Legends1-5 from Ki-67 as a Molecular Target for Therapy in an &lt;i&gt;In vitro&lt;/i&gt; Three-Dimensional Model for Ovarian Cancer
Supplementary Tables 1-5 from A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown (2023)

Supplementary Tables 1-5 from A Small Interfering RNA Screen of Genes Involved in DNA Repair Identifies Tumor-Specific Radiosensitization by POLQ Knockdown
80 Gb/s optical quadrature phase shift keying modulation using an integrated LiNbO&lt;inf&gt;3&lt;/inf&gt; modulator (2006)

We demonstrated 80 Gb/s optical differential quadrature-shift-keying modulation, by using a single-chip integrated LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> modulator with two sub Mach-Zehnder interferometers, where 40 Gb/s in-phase and quadrature data were, simultaneously, fed to the modulator.
Noncontrast Chest Computed Tomographic Imaging of Obesity and the Metabolic Syndrome (2019)

There are physiological consequences of overeating that can lead to increased morbidity and mortality. The purpose of this review article is to acquaint the reader with the current state of the art in the non-cardiac-gated, noncontrast chest computed tomographic (NCCT) imaging biomarkers of the metabolic syndrome and their prognostic significance found in the lower neck and chest. NCCT imaging biomarkers associated with metabolic syndrome in the chest include premature coronary artery calcification, acceleration of large vessel arterial and valvular calcifications associated with atherosclerosis, and pulmonary arterial enlargement from pulmonary hypertension associated with sleep apnea. These easily identified imaging biomarkers have prognostic implications for major adverse cardiac events (MACE). These NCCT chest-imaging biomarkers are likely targets for artificial intelligence algorithms to harvest for longitudinal assessment of their individual and multifactorial contributions to chronic disease, MACE, and mortality. Early recognition and treatment of these common disorders may help improve patient outcomes and quality of life while decreasing medical costs.
A versatile approach to fabricate modulated micro-/nanostructures by electrohydrodynamic structuring on prepatterned polymer (2016)

Micro-/nanostructures fabricated on functional polymers from physical principles can be highly desirable for polymer devices, owing to the physical integrity of the generated structure, the process economy and their environmentally friendly quality. However, current fabricating approaches can only duplicate a specific structure, or may require a complex technological procedure for the fabrication, i.e. for the fabrication of modulated micro-/nanostructures on polymer films on the basis of the physical principles, a versatile yet simple procedure is lacking. In this paper, electrohydrodynamic structuring on prepatterned polymer (ESPP) based on the electrohydrodynamic behavior of fluidic polymers in an electric field is proposed for the fabrication of a modulated structure on a functional polymer. For this purpose, a voltage is applied between a flat template and a flat substrate, sandwiching a prepatterned polymer and an air gap, resulting in a non-uniform upward pull on the polymer. This leads to a deformation of the polymer resulting in a structure corresponding to the initial morphology. This study explores the capability of ESPP in duplicating modulated structures by manipulating the electric field (which is also influenced by process parameters involving voltage and air gap length) from the perspective of theoretical analysis and experimental tests, which categorize the relationship between electrohydrodynamic pressure and surface tension into two regimes: one consisting of equilibrium modulation for convex structures potentially used as microlens arrays, and another comprising non-equilibrium modulation for high aspect ratio structures and potentially applicable to dry adhesives, superhydrophobic surfaces, etc. Furthermore, a criterion is proposed to distinguish between the two aforementioned regimes.
Nonlinear properties of RTP for second harmonic generation at 1030nm (2013)

Abstract: We demonstrate that around 1030 nm, RbTiOPO4 (RTP) realizes the second harmonic generation of Yb-doped lasers in non-critically phase-matched configuration at ambient temperature, with efficiencies comparable to LBO and wide thermal acceptance. Frequency doubled lasers are widely used in today’s industry, from micromachining to solid state pumping or spectrometry applications. While it is a nonlinear process fully mastered today, with conversion efficiencies routinely reaching more than 60%, it is still a technique sensitive to many outside parameters such as angular misalignments or temperature operation. In order to increase the robustness of a frequency conversion scheme, one needs to reduce the dephasing between the fundamental and the second harmonic cause by either an angle misalignment (angular sensitivity) or a temperature change (thermal sensitivity). RbTiOPO4 (RTP) is an isomorph of KTP, used mainly for high repetition rate electro-optic modulators [1]. Since its discovery, its optical and nonlinear properties have been widely studied: among them, one very interesting feature is its large thermal acceptance centered at 100°C for SHG at 1064 nm [2], and simultaneous temperature non-sensitive and angular non-critical SHG at 1030 nm at room-temperature [3]. In addition to its non-linear properties comparable to KTP, it should be a good candidate for highly stable, frequency doubled lasers. The refractive indexes of RTP have been precisely characterized in previous works [3], and show that type-II non-critical phase
Importance of appropriate pharmaceutical management in pregnant women with ulcerative colitis (2013)

UC patients wishing to conceive should do so when in remission and continue appropriate pharmaceutical treatment during pregnancy.
Phase Coherence in Conceptual Spaces for Conversational Agents (2010)

This chapter attempts to enhance the traditional chatbots with associative/intuitive capabilities. According to these considerations, it tries to create a conversational agent model that takes into consideration, aside from the traditional rule - based dialogue mechanism, also some sort of intuitive reasoning ability. The aim is in attempting to overcome the rigid pattern - matching rules, proposing a “phase coherence” paradigm into a semantic space. With this locution the chapter intend that the vectors representing the elements of the dialogue are coherent with the context. The chapter trust that this intuitive - associative capability can be obtained using the LSA methodology. The representation of information in a LSA - based semantic, “conceptual,” manifold and the resulting subsymbolic geometric representation of the chatbot knowledge can contribute to better design a humanlike conversational interface provided with both intuitive - associative capabilities and a rulebased dialogue skill. Controlled Vocabulary Terms semantic Web
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion (2020)

Ozonide antimalarials, OZ277 (arterolane) and OZ439 (artefenomel), are synthetic peroxide-based antimalarials with potent activity against the deadliest malaria parasite, Plasmodium falciparum. Here we used a "multi-omics" workflow, in combination with activity-based protein profiling (ABPP), to demonstrate that peroxide antimalarials initially target the haemoglobin (Hb) digestion pathway to kill malaria parasites. Time-dependent metabolomic profiling of ozonide-treated P. falciparum infected red blood cells revealed a rapid depletion of short Hb-derived peptides followed by subsequent alterations in lipid and nucleotide metabolism, while untargeted peptidomics showed accumulation of longer Hb-derived peptides. Quantitative proteomics and ABPP assays demonstrated that Hb-digesting proteases were increased in abundance and activity following treatment, respectively. Ozonide-induced depletion of short Hb-derived peptides was less extensive in a drug-treated K13-mutant artemisinin resistant parasite line (Cam3.IIR539T) than in the drug-treated isogenic sensitive strain (Cam3.IIrev), further confirming the association between ozonide activity and Hb catabolism. To demonstrate that compromised Hb catabolism may be a primary mechanism involved in ozonide antimalarial activity, we showed that parasites forced to rely solely on Hb digestion for amino acids became hypersensitive to short ozonide exposures. Quantitative proteomics analysis also revealed parasite proteins involved in translation and the ubiquitin-proteasome system were enriched following drug treatment, suggestive of the parasite engaging a stress response to mitigate ozonide-induced damage. Taken together, these data point to a mechanism of action involving initial impairment of Hb catabolism, and indicate that the parasite regulates protein turnover to manage ozonide-induced damage.
Determinants of the Pace of Global Innovation in Energy Technologies (2013)

Understanding the factors driving innovation in energy technologies is of critical importance to mitigating climate change and addressing other energy-related global challenges. Low levels of innovation, measured in terms of energy patent filings, were noted in the 1980s and 90s as an issue of concern and were attributed to limited investment in public and private research and development (R&D). Here we build a comprehensive global database of energy patents covering the period 1970-2009, which is unique in its temporal and geographical scope. Analysis of the data reveals a recent, marked departure from historical trends. A sharp increase in rates of patenting has occurred over the last decade, particularly in renewable technologies, despite continued low levels of R&D funding. To solve the puzzle of fast innovation despite modest R&D increases, we develop a model that explains the nonlinear response observed in the empirical data of technological innovation to various types of investment. The model reveals a regular relationship between patents, R&D funding, and growing markets across technologies, and accurately predicts patenting rates at different stages of technological maturity and market development. We show quantitatively how growing markets have formed a vital complement to public R&D in driving innovative activity. These two forms of investment have each leveraged the effect of the other in driving patenting trends over long periods of time.
Self-Crossover Based Genetic Algorithm for Performance Augmentation of the Traveling Salesman Problem (2011)

A genetic algorithm (GA) based approach to the path representation of the Traveling Salesman Problem (TSP) will be presented towards potential application to co-operative control of a group of UAVs. The scenario involves a random distribution of cities on a two dimensional grid or a pre-defined set of targets, and determines the optimal path solution of the TSP by means of an iterative algorithm. Similar codes based on genetic algorithms are in existence; however, a unique set of modifications are utilized in this study. Generally speaking, when applying a GA to the TSP, traditional crossover is not permitted, as a city could be visited twice using this method. To circumvent this issue and optimize algorithm efficiency, we introduce a concept referred to as SCROOGE (Self CROssover Optimal GEnetic algorithm). This algorithm will be utilizing a combination of self-crossover and mutation of the strings making up the population. Through selfcrossover, a single string is chosen for breeding, and has a chance to produce an offspring based off of its own genetic material, much as a starfish or many other animals would in nature. Additionally, SCROOGE’s parameters morph with time, becoming more focused on avoiding local minima as iterations progress.
A Novel Cost Function for Decision-Making Strategies in Automotive Collision Avoidance Systems (2018)

Nowadays, the automotive advanced driver assistance systems have the ability to detect surrounding objects, predict impending collisions and initiate automatic emergency braking. However, by a late detection of objects at higher speeds, the collision is hardly avoidable by braking only, hence an evasive steering maneuver shall be performed simultaneously to cure this deficiency. This paper presents a novel approach that utilizes a dedicated cost function to make the appropriate maneuver decision in an imminent collision avoidance situation. By taking into account the host vehicle and the collision target motions as well as other moving or stationary objects in the near vicinity, diverse aspects and criteria are analyzed and discussed to evaluate possible maneuver candidates. After that, the cost functions of different maneuvers are calculated by summarizing the results of all the evaluation criteria and aspects. In both simulated and measured critical situations, the cost function is validated and the maneuver with the best (i.e., lowest) cost is selected to avoid the impending collision and the endangerment of any other road users aside.
Streamlining the CAM programming process by Lean Principles within the aerospace industry (2015)

The search for increased productivity and cost reduction in machining can be interpreted as the desire to increase the material removal rate, MRR, and maximize the cutting tool utilization. The CNC process is complex and involves numerous limitations and parameters, ranging from tolerances to machinability. A well-managed preparation process creates the foundations for achieving a reduction in manufacturing errors and machining time. Along the preparation process of the NC-program, two different studies have been conducted and are presented in this thesis. One study examined the CAM programming preparation process from the Lean perspective. The other study includes an evaluation of how the cutting tools are used in terms of MRR and tool utilization.The material removal rate is defined as the product of three variables, namely the cutting speed, the feed and the depth of cut, which all constitute the cutting data. Tool life is the amount of time that a cutting tool can be used and is mainly dependent on the same variables. Two different combinations of cutting data might provide the same MRR, however the tool life will be different. Thereby the difficulty is to select the cutting data to maximize both MRR and cutting tool utilization. A model for the analysis and efficient selection of cutting data for maximal MRR and maximal tool utilization has been developed and is presented. The presented model shortens the time dedicated to the optimized cutting data selection and the needed iterations along the program development.
Toward Bottom-Up Understanding of Transport in Concentrated Battery Electrolytes (2022)

Bottom-up understanding of transport describes how molecular changes alter species concentrations and electrolyte voltage drops in operating batteries. Such an understanding is essential to predictively design electrolytes for desired transport behavior. We herein advocate building a structure-property-performance relationship as a systematic approach to accurate bottom-up understanding. To ensure generalization across salt concentrations as well as different electrolyte types and cell configurations, the property-performance relation must be described using Newman's concentrated solution theory. It uses Stefan-Maxwell diffusivity, <sub><i>ij</i></sub> , to describe the role of molecular motions at the continuum scale. The key challenge is to connect <sub><i>ij</i></sub> to the structure. We discuss existing methods for making such a connection, their peculiarities, and future directions to advance our understanding of electrolyte transport.
Smart antenna concepts for time-slotted CDMA (2002)

Currently, smart antenna concepts for mobile radio systems applicable at the base station (BS) are subject to worldwide research activities. Taking advantage of the directional inhomogeneity of mobile radio channels, the application of smart antenna concepts in cellular mobile radio is expected to increase the admissible number of users and to decrease both the cluster order, i.e. the number of cells per cluster, and the transmission powers. Three different approaches to smart antenna concepts applying receiver antenna diversity at the uplink receiver with different antenna configurations are investigated for a time-slotted CDMA mobile radio system termed joint detection CDMA (JD-CDMA). In order to quantify the obtainable performance improvements, the spectral efficiency, which measures the information rate per unit bandwidth and per cell, is considered. The paper describes a method to determine said spectral efficiency by means of simulations. This method is applied to the uplink of a JD-CDMA mobile radio system explicitly taking the three aforementioned smart antenna concepts into account.