gebhart/patrepeval huggingface dataset:
Design algorithm of multi-segment dielectric resonator antennas(MSDRAs) (2005)

This paper introduces a simple design algorithm for MSDRAs. The algorithm avoids prior time consuming trial and error processes for achieving the optimum parameters of MSDRA and gives an antenna with best possible impedance bandwidth in desired feedline-MSDRA coupling. To show the efficiency of the algorithm, two examples are examined in X-band. The examples are simulated using two numerical methods. Then adjusting the position of the MSDRA with respect to the open end of the microstrip line is proposed to maximize the feedline-MSDRA coupling.
LMDS from high altitude aeronautical platforms (2003)

System level design considerations for high altitude aeronautical platforms operating in the LMDS band are examined. Propagation effects in the LMDS band are outlined, followed by a brief introduction to different platform scenarios. Ground-based and platform-based fixed wireless access scenarios are considered, and it is shown that using a platform, considerably longer link lengths can be used. The effects on performance of platform displacement from its desired location with both fixed and steerable antennas are also examined. It is shown that steerable antennas are of most use when fixed stations are immediately below the platform, with no benefit for fixed stations on the edge of coverage.
Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice (2012)

Cold-inducible RNA-binding protein (Cirp) was the first cold-shock protein identified in mammals. It is structurally quite different from bacterial cold-shock proteins and is induced in response to mild, but not severe, hypothermia. To clarify the physiological function of Cirp in vivo, we produced cirp-knockout mice. They showed neither gross abnormality nor defect in fertility, but the number of undifferentiated spermatogonia was significantly reduced and the recovery of spermatogenesis was delayed after treatment with a cytotoxic agent, busulfan. Cirp accelerated cell-cycle progression from G0 to G1 as well as from G1 to S phase in cultured mouse embryonic fibroblasts. Cirp directly bound to dual-specificity tyrosine-phosphorylation-regulated kinase 1B (Dyrk1b, also called Mirk) and inhibited its binding to p27, resulting in decreased phosphorylation and destabilization of p27. Cirp did not affect binding of Dyrk1b to cyclin D1 but inhibited phosphorylation of cyclin D1 by Dyrk1b, resulting in cyclin D1 stabilization. In the spermatogonial cell line GC-1spg, suppression of Cirp expression increased the protein level of p27, decreased that of cyclin D1, and decreased the growth rate, which depended on Dyrk1b. Consistent changes in the protein levels of p27 and cyclin D1 as well as the percentage of cells in G0 phase were observed in undifferentiated spermatogonia of cirp-knockout mice. In undifferentiated spermatogonia of wild-type mice, Cirp and Dyrk1b colocalized in the nucleus. Thus, our study demonstrates that Cirp functions to fine-tune the proliferation of undifferentiated spermatogonia by interacting with Dyrk1b.
Chapter 10 | Stainless Bearing Steels (2022)

Corrosion resistance is imparted to rolling bearing steels by the addition of a minimum of approximately 14 wt.% of chromium to the composition and substitution of carbon by nitrogen. Applications requiring enhanced corrosion resistance and good cryogenic properties use steels with both chromium and nitrogen alloying. Corrosion properties are affected by the applied steelmaking and heat treatment. Steelmaking processes based on powder metallurgy and hot isostatic pressing are of relevance to rolling bearing steel technologies (see later chapter of this book covering powder metallurgy). Corrosion testing methods vary from relatively simple corrosive medium immersion tests (NAVY) to advanced corrosion rate testing using anodic polarization (AP) and electrochemical impedance spectroscopy (EIS). ASTM G5-14(2021), Standard Reference Test Method for Making Potentiodynamic Anodic Polarization Measurements, can be used to prepare AP curves to compare corrosion resistant rolling bearing steels. A reasonable correlation is found for the NAVY versus EIS testing of rolling bearing steels. The ASTM standard test methods such as ASTM G61 and ASTM B117 are useful methodologies in characterization of rolling bearing steel corrosion resistance. Numerous lower carbon alternatives exist to the traditional 440C rolling bearing corrosion resistant steel grade. The best corrosion resistance is obtained by nitrogen alloying, particularly if secondary hardening is required for high temperature hardness retention. Hot hardness is the dominant feature of rolling bearing in aerospace rolling bearing applications. For this a new generation of stand-still corrosion resistant high temperature rolling bearing steels, based on solution-nitriding, needs to be considered. The downside of enhancement of corrosion resistance, by removal of large chromium carbides from the microstructure, is a loss of abrasive wear resistance. The aerospace rolling bearing challenge of high temperature strength and toughness in combination with standstill corrosion resistance coupled with abrasive contaminate lubricant tolerance requires innovative steelmaking and heat treatment technologies as explained in Chapter 17 of this book.
A circular production of fish and vegetables in Guatemala : An in-depth analysis of the nitrogen cycle in the Maya Chay aquaponic systems (2018)

This study was done with the aim of deepening the understanding of the Maya Chay aquaponic systems. To meet the aim, a literature study on aquaponics, with an emphasis on the nitrogen metabolism in ...
Tapering of plasma density ramp profiles for adiabatic lens experiments (2018)

One of the key elements of the plasma wakefield blowout regime is the strong, linear focusing provided by the ion density. One advantage of this focusing is its extraordinary strength whose gradient is proportional to the local background plasma density, that is particularly important for adiabatic focusing schemes in future compact linear colliders. Local plasma density variations can be obtained in gas-filled capillaries by varying monotonically the diameter of the capillary. Here we present the ongoing study of the plasma density profile obtained for different tapering angles of the capillary shape and we discuss their use for the adiabatic plasma lens experiment proposed at SPARC_LAB.
Abstract 1494: PBRM1-deficient PBAF complexes target de novo genomic loci to activate NF-κB pathway in clear cell renal cell carcinoma (2023)

Abstract PBRM1 is an accessory subunit of the PBAF subclass of the SWI/SNF chromatin remodeler and the inactivation of PBRM1 is the second most frequent mutational event in kidney tumorigenesis. However, the impact of PBRM1 loss on chromatin remodeling, especially pertaining to kidney tumorigenesis, has not been examined previously. Here we show that in VHL-deficient ccRCC tumors, PBRM1 deficiency results in altered PBAF complexes that retain the association between SMARCA4 and ARID2 but disengage BRD7 from SMARCA4. The PBRM1-deficient PBAF complexes redistribute from promoter proximal regions to distal enhancer regions containing motifs of pro-tumorigenic factors including NF-κB. Subsequently, PBRM1-deficient cells display heightened NF-κB activity across multiple cell models. The ATPase function of SMARCA4 maintains chromatin occupancy of both pre-existing and newly acquired RELA specific to PBRM1 loss, and activates downstream target gene expression. Proteasome inhibitor bortezomib reverses NF-κB activation by reducing RELA occupancy and delays growth of PBRM1-deficient tumors. In conclusion, PBRM1 safeguards the chromatin by repressing aberrant liberation of pro-tumorigenic NF-κB target genes by residual PBRM1-deficient PBAF complexes. Citation Format: Xiaosai Yao, Jing Han Hong, Amrita Nargund, Michelle Shu Wen Ng, Hong Lee Heng, Zhimei Li, Peiyong Guan, Masahiro Sugiura, Pek Lim Chu, Loo Chien Wang, Xiaofen Ye, Robert Yauch, Kenneth Tou-En Chang, Radoslaw M. Sobota, Patrick Tan, Bin Tean Teh. PBRM1-deficient PBAF complexes target de novo genomic loci to activate NF-κB pathway in clear cell renal cell carcinoma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1494.
The design of fluoroquinolone-based cholinesterase inhibitors: Synthesis, biological evaluation and in silico docking studies (2021)

An enhanced acetylcholinesterase (AChE) activity is a hallmark in early stages of Alzheimer's ailment that results in decreased acetylcholine (ACh) levels, which in turn leads to cholinergic dysfunction and neurodegeneration. Consequently, inhibition of both AChE and butyrylcholinesterase (BChE) is important to prolong ACh activity in synapses for the enhanced cholinergic neurotransmission. In this study, a series of new fluoroquinolone derivatives (7a-m) have synthesized and evaluated for AChE and BChE inhibitory activities. The screening results suggested that 7 g bearing ortho fluorophenyl was the most active inhibitor against both AChE and BChE, exhibiting IC50 values of 0.70 ± 0.10 µM and 2.20 ± 0.10 µM, respectively. The structure–activity relationship (SAR) revealed that compounds containing electronegative functions (F, Cl, OMe, N and O) at the ortho position of the phenyl group exhibited higher activities as compared to their meta- and/or para substituted counterparts. Molecular docking studies of synthesized compounds 7a, 7g, 7j and 7l docked into the active site of AChE and 7a-f docked into the active site of BChE revealed that these compounds exhibited conventional H-bonding along with π-π interaction with the active residues of AChE through their electronegative functions and phenyl ring, respectively. All the synthesized compounds are characterized by spectroscopic methods including FT-IR, 1H- and 13C NMR as well as elemental analysis. This is the first example of fluoroquinolone-based cholinesterase inhibitors.
Isolation of bitter acids from hops (<i><scp>H</scp>umulus lupulus</i><scp>L</scp>.) using countercurrent chromatography (2012)

Commercially available hops (Humulus lupulus L.) bitter acid extracts contain a mixture of three major congeners (co-, n-, and ad-) in addition to cis/trans diastereomers for each congener. Individual isomerized α-acids were obtained by the consecutive application of two separate countercurrent chromatography methods. First, individual isomerized α-acid congeners as a mixture of cis/trans diastereomers were obtained using a solvent system consisting of hexane and aqueous buffer. The second purification, capable of separating cis/trans diastereomers, was accomplished using a quaternary solvent system; an alternative procedure using β-cyclodextrin followed by countercurrent chromatography was also investigated. The NaBH(4) reduction of the purified isomerized α-acid compounds followed by countercurrent chromatography purification resulted in individual ρ iso α-acids (>95%). Similarly, catalytic hydrogenation of the purified isomerized α-acid compounds followed by countercurrent chromatography purification produced individual tetrahydro isomerized α-acids (>95%). Reported herein is a widely applicable approach that focuses on three critical variables--solvent system composition, pH, and buffer-to-sample ratio--that enable the efficient purification of individual bitter acids (≥95%) from commercially available hops extracts.
Skin Cancer-Associated S. aureus Strains Can Induce DNA Damage in Human Keratinocytes by Downregulating DNA Repair and Promoting Oxidative Stress (2022)

Actinic keratosis (AK) is a premalignant lesion, common on severely photodamaged skin, that can progress over time to cutaneous squamous cell carcinoma (SCC). A high bacterial load of <i>Staphylococcus aureus</i> is associated with AK and SCC, but it is unknown whether this has a direct impact on skin cancer development. To determine whether <i>S. aureus</i> can have cancer-promoting effects on skin cells, we performed RNA sequencing and shotgun proteomics on primary human keratinocytes after challenge with sterile culture supernatant ('secretome') from four <i>S. aureus</i> clinical strains isolated from AK and SCC. Secretomes of two of the <i>S. aureus</i> strains induced keratinocytes to overexpress biomarkers associated with skin carcinogenesis and upregulated the expression of enzymes linked to reduced skin barrier function. Further, these strains induced oxidative stress markers and all secretomes downregulated DNA repair mechanisms. Subsequent experiments on an expanded set of lesion-associated <i>S. aureus</i> strains confirmed that exposure to their secretomes led to increased oxidative stress and DNA damage in primary human keratinocytes. A significant correlation between the concentration of <i>S. aureus</i> phenol soluble modulin toxins in secretome and the secretome-induced level of oxidative stress and genotoxicity in keratinocytes was observed. Taken together, these data demonstrate that secreted compounds from lesion-associated clinical isolates of <i>S. aureus</i> can have cancer-promoting effects in keratinocytes that may be relevant to skin oncogenesis.
Synthesis and Chemistry of 2-(Dibromophosphino)-4,5-dimethylphosphinine (1996)

The reaction of PBr3 with 2-bromo-4,5-dimethylphosphinine in the presence of traces of H+ or O2 leads to a transient 1,1-dibromo-λ5-phosphinine whose reduction by P(CH2CH2CN)3 gives the title compound (3). It is possible to transpose with 3 most of the classical reactions of phenyldibromophosphine despite the presence of the reactive phosphorus atom of the phosphinine nucleus. The reaction of 3 with 2 equiv of nucleophiles (Nu- = R-, RO-, RS-, R2N-) gives the expected 2-PNu2 derivatives. The reduction of 3 by LiAlH4 gives the primary phosphine 14 whose P-anion 15 is surprisingly stable. The phosphinine nucleus of 3 also withstands electrophilic conditions. Thus, the reaction of 3 with diphenylacetylene in the presence of AlCl3 yields the expected phosphirenium salt, whose reduction leads to the 2-phosphirenylphosphinine 17. A further ring expansion to the four-membered 1,2-dihydrophosphete 18 is also possible.
Oncogenic Potential of the c-FMS Proto-Oncogene (CSF-1 Receptor) (2003)

A brief review of the paper:Transforming Potential of the C-fms Proto-Oncogene (CFS-1 Receptor) Roussel MF, Dull TJ, Rettenmier CW, Ralph P, Ullrich A, Sherr CJ. Nature 1987 1987; 325: 549-552.
Electrochemical Properties of Carbon-Coated Lithium Vanadium Oxide Anode for Lithium-Ion Battery (2010)

Abstract not Available.
Dynamics of Silylenes in Polysilylenes with Structural Defects by Excimer Laser Flash Photolysis (2001)

Abstract The dynamics of silylene extrusion reaction was observed in polysilylene with Si branchings by using KrF excimer laser flash photolysis technique. The initial yield of silyl radicals was seen to be dependent on the backbone structure of polysilylenes, whereas the yield of silylenes was almost proportional to the number of the linear Si units in their backbones.
Small signal analysis for analogue optical links with arbitrary optical transfer function (2004)

A new analytical expression (the conversion matrix) for the effect of an arbitrary optical transfer function on small signal RF modulation is presented with applications to linear-frequency-modulated (LFM) signals. Chromatic dispersion of any order can be investigated, as well as wavelength-dependent insertion loss.
Bimetallic ruthenium–rhodium particles supported on carbon nanotubes for the hydrophosphinylation of alkenes and alkynes (2022)

RuRh bimetallic particles supported on carbon nanotubes were applied to the hydrophosphinylation of alkenes and alkynes. This recyclable system operates under sustainable conditions: low catalyst loading, room temperature and atmospheric pressure.
Industrial Trends and Roadmap of Access (2016)

Optical access has grown in speed from 50 Mb/s pi-PON to 10 Gb/s XG-PON. Further capacity increases are envisioned to employ multiple wavelengths and advanced line coding. This paper reviews the current trends in access, and predicts a likely roadmap.
Trend: Spintronics without magnetism (2009)

The spin-orbit effect is at the heart of efforts to merge spintronics—where information is carried and stored by spin, rather than by charge—with semiconductor technology.
Association of β-catenin with the α-subunit of neuronal large-conductance Ca <sup>2+</sup> -activated K+ channels (2003)

The association of Ca(2+)-activated K(+) channels with voltage-gated Ca(2+) channels at the presynaptic active zones of hair cells, photoreceptors, and neurons contributes to rapid repolarization of the membrane after excitation. Ca(2+) channels have been shown to bind to a large set of synaptic proteins, but the proteins interacting with Ca(2+)-activated K(+) channels remain unknown. Here, we report that the large-conductance Ca(2+)-activated K(+) channel of the chicken's cochlear hair cell interacts with beta-catenin. Yeast two-hybrid assays identified the S10 region of the K(+) channel's alpha-subunit and the ninth armadillo repeat and carboxyl terminus of beta-catenin as necessary for the interaction. An antiserum directed against the alpha-subunit specifically coprecipitated beta-catenin from brain synaptic proteins. beta-Catenin is known to associate with the synaptic protein Lin7/Velis/MALS, whose interaction partner Lin2/CASK also binds voltage-gated Ca(2+) channels. beta-Catenin may therefore provide a physical link between the two types of channels at the presynaptic active zone.
ChemInform Abstract: The Influence of Metal Oxides on the Activity and Selectivity of Transition Metal Catalysts (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Study on discoloration of PVC profiles caused by surface sulfur contamination (2010)

The sources of materials causing sulfur contamination discoloration on PVC profiles surface were studied in detail as well as conditions of influencing sulfur contamination discoloration.Solutions were proposed.
Could Immunosuppressive Drugs Reduce Recurrence Rate After Second Resection for Crohn Disease? (2004)

In patients treated with IS drugs, the rate of postoperative recurrence after second ileocolonic CD resection is lower than in untreated patients. Our results suggest that IS drugs should be evaluated prospectively for prevention of second postoperative CD recurrence.
Neonatal invariant Vα24+ NKT lymphocytes are activated memory cells (2000)

NKT cells are a small subset of T lymphocytes which express an invariant V(alpha24JalphaQ TCR and recognize glycolipids presented by CD1d. In adults, NKT cells have a memory phenotype, frequently associated with oligoclonal expansion, express NK cell markers, and produce TO cytokines upon primary stimulation. Because of these features, NKT cells are regarded as lymphocytes of innate immunity. We investigated NKT cells from cord blood to see how these cells appear in the absence of exogenous stimuli. We found that NKT cells are present at comparable frequencies in cord blood and adult peripheral blood mononuclear cells and in both cases display a memory (CD45RO+CD62L-) phenotype. However, neonatal NKT cells differ from their adult counterparts by the following characteristics: (1) they express markers of activation, such as CD25; (2) they are polyclonal; (3) they do not produce cytokines in response to primary stimulation. Together, our data show that human NKT cells arise in the newborn with an activated memory phenotype, probably due to recognition of an endogenous ligand(s). The absence of oligoclonal expansion and primary effector functions also suggest that neonatal NKT cells, despite their activated memory phenotype, require a further priming/differentiation event to behave as fully functional cells of innate immunity.
Subnanogram-concentration measurement of buprenorphine in human plasma by electron-capture capillary gas chromatography: application to pharmacokinetics of sublingual buprenorphine. (1997)

We describe a sensitive and specific method for the measurement of buprenorphine in human plasma. The method involves a structural analog as an internal calibrator, careful control of pH during sample extraction to maximize drug recovery, and back-extraction into acid followed by reextraction to eliminate endogenous interferences. After evaporation, sample residues are derivatized with heptafluorobutyric anhydride and analyzed by separation on a fused-silica polymethylsiloxane capillary column and electron-capture detection. Calibration curves were linear in the ranges 0.1-2.0 micrograms/L and 2.0-20 micrograms/L, with within-run CVs of 9.7% at 0.1 microgram/L to 5.0% at 20 micrograms/L, and total CVs of 15.9% at 0.1 microgram/L to 6.5% at 10 micrograms/L. The limit of quantification was 0.1 microgram/L. The method was utilized in studies to determine the absolute bioavailability of sublingual doses of 2 mg of buprenorphine in 1 mL of 300 mL/L ethanol and the bioequivalence of sublingual 8-mg tablet and 300 mL/L ethanol solution formulations.
Porous Biomimetic Hyaluronic Acid and Extracellular Matrix Protein Nanofiber Scaffolds for Accelerated Cutaneous Tissue Repair (2019)

Recent reports suggest the utility of extracellular matrix (ECM) molecules as raw components in scaffolding of engineered materials. However, rapid and tunable manufacturing of ECM molecules into fibrous structures remains poorly developed. Here we report on an immersion rotary jet-spinning (iRJS) method to show high-throughput manufacturing (up to ∼1 g/min) of hyaluronic acid (HA) and other ECM fiber scaffolds using different spinning conditions and postprocessing modifications. This system allowed control over a variety of scaffold material properties, which enabled the fabrication of highly porous (70–95%) and water-absorbent (swelling ratio ∼2000–6000%) HA scaffolds with soft-tissue mimetic mechanical properties (∼0.5–1.5 kPa). Tuning these scaffolds’ properties enabled the identification of porosity (∼95%) as a key facilitator for rapid and in-depth cellular ingress in vitro. We then demonstrated that porous HA scaffolds accelerated granulation tissue formation, neovascularization, and reepithelialization in vivo, altogether potentiating faster wound closure and tissue repair. Collectively, this scalable and versatile manufacturing approach enabled the fabrication of tunable ECM-mimetic nanofiber scaffolds that may provide an ideal first building block for the design of all-in-one healing materials.