gebhart/patrepeval huggingface dataset:
Visualization assisted by parallel processing (2010)

This paper discusses the experimental results of our visualization model for data extracted from sensors. The objective of this paper is to find a computationally efficient method to produce a real time rendering visualization for a large amount of data. We develop visualization method to monitor temperature variance of a data center. Sensors are placed on three layers and do not cover all the room. We use particle paradigm to interpolate data sensors. Particles model the "space" of the room. In this work we use a partition of the particle set, using two mathematical methods: Delaunay triangulation and Vorono¨ý cells. Avis and Bhattacharya present these two algorithms in. Particles provide information on the room temperature at different coordinates over time. To locate and update particles data we define a computational cost function. To solve this function in an efficient way, we use a client server paradigm. Server computes data and client display this data on different kind of hardware. This paper is organized as follows. The first part presents related algorithm used to visualize large flow of data. The second part presents different platforms and methods used, which was evaluated in order to determine the better solution for the task proposed. The benchmark use the computational cost of our algorithm that formed based on located particles compared to sensors and on update of particles value. The benchmark was done on a personal computer using CPU, multi core programming, GPU programming and hybrid GPU/CPU. GPU programming method is growing in the research field; this method allows getting a real time rendering instates of a precompute rendering. For improving our results, we compute our algorithm on a High Performance Computing (HPC), this benchmark was used to improve multi-core method. HPC is commonly used in data visualization (astronomy, physic, etc) for improving the rendering and getting real-time.
Green Perovskite Distributed Feedback Lasers (2017)

A visible perovskite distributed feedback laser is fabricated for the first time. Through the use of nanocrystal pinning, highly luminescent methylammonium lead bromide films are used to produce stable lasers emitting at 550 nm, with a low threshold of 6 µJcm<sup>-2</sup>. The lasers were able to support multiple polarisations, and could be switched between transverse magnetic and transverse electric mode operation through simple tuning of the distributed feedback grating period.
Rotor Cooling of Internal Mixer (2015)

It has become important to consider global environmental issue. In order to reduce fuel consumption of automobiles, development of low rolling resistance tires has been promoted. They are mostly made of rubber compound filled with silica. Rubber temperature control in mixer has become more important, because silica mixing, with silane coupling reaction, needs to be under constant temperature for better mixing quality. Mixer temperature is controlled by water cooling of chambers and rotors. There have been some qualitative approaches about mixer cooling. However, quantitative prediction of rotor cooling would be still little. Heat conduction analysis of rotor, under steady and unsteady condition, had been carried out to investigate rotor cooling of internal type mixer. The results of unsteady analysis were mostly accorded with experimental results, and heat release rates from rotors in operating conditions were predicted by steady analysis. In the future, this analysis could be applied for design of different shape rotor or scale up of mixer and be coupled with flow analysis in mixers or structural analysis of rotors.
Screening of Monoclonal Antibodies Using Antigens Labeled with Acetylcholinesterase (2003)

The production of large quantities of monoclonal antibodies (MAbs) of predetermined specificity has been rendered possible by the pioneering work of Köhler and Milstein (1). These workers have shown that lymphocytes can be immortalized and subsequently cultured after somatic fusion with genetically selected myeloma cells. Usually, once fusion between spleen cells and myeloma cells has been performed, cells are suspended in a large volume of selective medium and distributed in culture wells, so that hybridomas are brought to clonal dilution. If fusion is successful, the first hybridoma colonies will be detectable within a few days (5-15 d). As fusion is a random process, most clones code for MAbs of unknown specificity, characterizing the immunological past of the host. It is then necessary to select the different colonies that secrete MAbs of the desired specificity. Owing to the great number of wells to be tested (often a few hundred), and to the small quantities of MAbs available (at best, 300 µL at a few µg/mL), it is not easy at this stage to characterize the fine specificity of the antibodies (i.e., recognition of a precise epitope, inhibitory effect on a biological system, properties suitable for purifying antigen, or for histochemical characterization, and so on). Initially, it is generally preferable to use a simple method to select all the hybridomas producing MAbs directed against the immunizing antigen. Further characterization of these MAbs is performed later, after expansion of the clones.
Protopanaxadiol aglycone ginsenoside-polyethylene glycol conjugates: synthesis, physicochemical characterizations, and<i>in vitro</i>studies (2015)

Ginsenosides are triterpenoid saponins, which is an active compound responsible for most of the pharmacological effects of ginseng (Panax ginseng Meyer). It is known to have numerous structural and pharmacological properties. However, aqueous solubility and delivery of ginsenosides in targeted region by avoiding undesirable toxicity to normal cell is also of prime importance. The aim of this study was to obtain amphiphilic ginsenoside derivatives in which hydrophilic polymers were conjugated to ginsenosides to enhance the water solubility and targeted delivery. To this end, the hydrophobic protopanaxadiol ginsenoside aglycone (aPPD) was covalently conjugated to the backbone of hydrophilic polyethylene glycol (PEG) through a pH sensitive ester linkage, which was confirmed by <sup>1</sup>H NMR and FTIR. The resultant PPD is covalently conjugated to hydrophilic PEG through esterification (PEG-PPD) forming self-assembled spherical nanoparticles, whose average particle diameter was 189 nm as observed by FE-TEM and particle size analyzer respectively. In vitro release experiments revealed that the release rate of PPD was rapidly increased from the self-assembled nanoparticles under acidic conditions (pH 5.0) than in a physiological buffer (pH 7.4) condition. Furthermore, in vitro cytotoxicity assays revealed that PEG-PPD conjugates exhibited lower cytotoxicity in HT-29 cancer cells compared with PPD alone. Since the slow release of PPD from conjugates is triggered only by acidic environmental conditions, such as those found in extracellular solid tumor tissues, intracellular endosomes, and intracellular lysosomes, the conjugation of PPD may aid its selective delivery to these targets. Overall, results suggest that pH-dependent release of PPD, which expected in reduced cytotoxicity to non-targeted regions, may enhance the overall efficacy of PPD.
Data-driven time-frequency analysis of seismic data using regularized nonstationary autoregression (2016)

Time-frequency decomposition can capture the nonstationary character of seismic data. In this paper, we propose a new method of time-frequency analysis based on regularized nonstationary autoregression coupled with Hilbert-Huang spectrum (RNARHHS). RNARHHS is an empirical-mode-decomposition like method but uses regularized nonstationary autoregression to construct its intrinsic mode functions (IMFs). Examples of synthetic and field seismic data show that this method achieves high time-frequency resolution and can detect low-frequency anomalies. Presentation Date: Tuesday, October 18, 2016 Start Time: 8:00:00 AM Location: 170/172 Presentation Type: ORAL
Numerical Modeling of Abnormal Blocking Effect for the Design of Novel Optical Sensor Element Constructed by Periodic Grating Strips Over Si/SiO<sub>2</sub> Wire Waveguide (2018)

In this paper the numerical modeling of periodic structures for implementation of a novel type of photonic sensors by using the 3D finite difference time domain (FDTD) method is presented. The sensing is based on the optical phenomena occurring in the segmented grating which is placed on the thin silica buffer over the silicon wire waveguide in the silicon‐on‐insulator (SOI) structure. This design provides the effective resonance interaction of the guided wave with the virtual leaky wave supported by the segmented grating evanescently coupled with the silicon wire. The dropping wavelength of this interaction is strongly dependent on the grating environment and it provides a strong refractometricsensitivity ( S n &gt; 420 nm RIU −1 ) and surface sensitivity S h &gt; 0.17, evaluated in the case of water. The modeling proves that the effect of abnormal blocking due to virtual leaky wave could be the base for the design of optical sensors with extremely high sensitivity.
Policies and IT technologies: a puzzle of two pieces (2006)

Starting with this issue, a new public policy technology track appears in each installment of IEEE Internet Computing in 2006. This track explores the relationships between IT technology deployment and policies along with the policy-related factors that affect the deployment of specific technologies. In this installment, the authors describe their vision of what to expect in future issues, and issue a call to arms to build a like-minded community.
Process‐induced cell cycle oscillations in CHO cultures: Online monitoring and model‐based investigation (2019)

The influence of process strategies on the dynamics of cell population heterogeneities in mammalian cell culture is still not well understood. We recently found that the progression of cells through the cell cycle causes metabolic regulations with variable productivities in antibody-producing Chimese hamster ovary (CHO) cells. On the other hand, it is so far unknown how bulk cultivation conditions, for example, variable nutrient concentrations depending on process strategies, can influence cell cycle-derived population dynamics. In this study, process-induced cell cycle synchronization was assessed in repeated-batch and fed-batch cultures. An automated flow cytometry set-up was developed to measure the cell cycle distribution online, using antibody-producing CHO DP-12 cells transduced with the cell cycle-specific fluorescent ubiquitination-based cell cycle indicator (FUCCI) system. On the basis of the population-resolved model, feeding-induced partial self-synchronization was predicted and the results were evaluated experimentally. In the repeated-batch culture, stable cell cycle oscillations were confirmed with an oscillating G1 phase distribution between 41% and 72%. Furthermore, oscillations of the cell cycle distribution were simulated and determined in a (bolus) fed-batch process with up to <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mn>25</mml:mn><mml:mo>×</mml:mo><mml:mn>1</mml:mn><mml:msup><mml:mn>0</mml:mn><mml:mn>6</mml:mn></mml:msup></mml:mrow></mml:math> cells/ml. The cell cycle synchronization arose with pulse feeding only and ceased with continuous feeding. Both simulated and observed oscillations occurred at higher frequencies than those observable based on regular (e.g., daily) sample analysis, thus demonstrating the need for high-frequency online cell cycle analysis. In summary, we showed how experimental methods combined with simulations enable the improved assessment of the effects of process strategies on the dynamics of cell cycle-dependent population heterogeneities. This provides a novel approach to understand cell cycle regulations, control cell population dynamics, avoid inadvertently induced oscillations of cell cycle distributions and thus to improve process stability and efficiency.
A Family of Putative Receptor-Adenylate Cyclases from Leishmania donovani (1995)

Leishmania parasites are exposed to pronounced changes in their environment during their life cycle as they migrate from the sandfly midgut to the insect proboscis and then into the phagolysosomes of the vertebrate macrophages. The developmental transformations that produce each life cycle stage of the parasite may be signaled in part by binding of environmental ligands to receptors which mediate transduction of extracellular signals. We have identified a family of five clustered genes in Leishmania donovani which may encode signal transduction receptors. The coding regions of two of these genes, designated rac-A and rac-B, have been sequenced and shown to code for proteins with an NH2-terminal hydrophilic domain, an intervening putative transmembrane segment, and a COOH-terminal domain that has high sequence identity to the catalytic domain from adenylate cyclases in other eukaryotes. We have expressed the receptor-adenylate cyclase protein (RAC)-A protein in Xenopus oocytes and demonstrated that it functions as an adenylate cyclase. Although RAC-B exhibits no catalytic activity when expressed in oocytes, co-expression of RAC-A and RAC-B negatively regulates the adenylate cyclase activity of RAC-A, suggesting that these two proteins interact in the membrane. Furthermore, a truncated version of RAC-A functions as a dominant negative mutant that inhibits the catalytic activity of the wild type receptor. The rac-A and rac-B genes encode developmentally regulated mRNAs which are expressed in the insect stage but not in the mammalian host stage of the parasite life cycle.
Interferometric measurement of the optical phase distribution for Fresnel diffraction by a straightedge (1979)

The phase structure of the optical field diffracted from a straightedge has been measured using an ac interferometer. The measured phase distribution is in good agreement with the predictions of scalar diffraction theory.
Electron field emission from nanostructured semiconductors under photo illumination (2014)

New device concepts and materials for the fabrication of compact high-frequency vacuum sources and micro-nano-integrated X-ray sources are of particular interest for broadband communication, security screening of packages and chemical materials, biomedical examination, and other applications. This article integrates results on GaN- and ZnO-based nano and self-assembled structures. They were used as field emitter tips for cold electron emission at high local electric fields as well as for photoassisted field emitters to generate bunched electrons directly from the emitter tip. The results on functional field emitters as cold electron sources will be presented. They are key elements for building, among other miniaturized vacuum tubes. Such miniaturized vacuum tubes can achieve high power at high cutoff frequencies and overcome the limitations of conventional GaAs- or InP-based solid-state devices. Furthermore, new functional X-ray sources with ultrashort pulses will allow 3D imaging with low radiation doses.
Neurocomputing and Neurooptimization with Stochastic Memristive Networks (2021)

Summary form only given, as follows. The complete presentation was not made available for publication as part of the conference proceedings. Stochastic neural networks have become the state-of-the-art approach for solving machine learning problems, information theory, and statistics. The critical operation in such networks is a stochastic dotproduct. While there have been many demonstrations of dot-product circuits and, separately, stochastic neurons, the efficient hardware implementation combining both functionalities is still missing. In my talk, I will discuss our recent work on addressing this need. I will first discuss compact, fast, energy-efficient, and scalable stochastic dot-product circuits based on passively integrated metal-oxide memristors. The high performance of such circuits is due to mixed-signal implementation. Simultaneously, the efficient stochastic operation is achieved by utilizing the circuit’s noise, intrinsic and/or extrinsic to the memory cell array. The dynamic scaling of weights, enabled by analog memory devices, allows for efficient realization of different annealing approaches to improve functionality. I will then discuss several application demonstrations based on passively integrated TiO2-x memristors, including Hopfield networks for solving combinatorial optimization problems and a Boltzmann machine.
Assembly of Topographical Micropatterns with Optoelectronic Tweezers (2019)

Abstract Topographical micropatterns (TMPs), or ordered arrays of 3D features on a flat surface, have become important for a wide range of applications. A new optofluidic method based on optoelectronic tweezers to assemble TMPs from suspensions of microparticles in fluid is reported. After assembly, TMPs can be freeze‐dried and then transferred to alternate substrates. 3D simulations are carried out to clarify the experimental results and techniques are developed to evaluate pattern‐transfer fidelity, which is found to be &gt;90% for a wide range of different structures. The optofluidic assembly method described here is facile and accessible, suggesting utility for a wide range of microfabrication and microassembly applications in the future.
Cloning of a putative GABAA receptor from cyclodiene-resistant Drosophila: A case study in the use of insecticide-resistant mutants to isolate neuroreceptors (1993)

This chapter uses the isolation and cloning of cyclodiene resistance from Drosophila melanogaster to illustrate how mutants resistant to a toxicant can be used to study neuroreceptors. Isolation of mutants from the field, mapping of the single gene responsible and its subsequent cloning are described. As confirmation of gene cloning a susceptible allele of the gene has been used to genetically transform resistant individuals to susceptibility. The gene product appears to code for a subunit of a receptor highly similar to vertebrate GABAA receptor/chloride ion channels, and functional expression studies are described which will elucidate its pharmacology. Cyclodiene resistance is extremely widespread, occurring in both invertebrates and vertebrates. Thus examination of resistance-associated mutations in this receptor in a range of species will enhance our understanding of both the binding sites of toxic ligands and the genetic basis of pesticide resistance.
A GENERAL-PURPOSE PROCEDURE FOR COMPLEX GRAPHIC SYMBOL RECOGNITION (1996)

A general-purpose procedure for the recognition of graphic symbols in line-drawing images is presented here. The method assumes that a noise-free symbol database is available and that both the model symbols and the processed image have been broken down into elementary structures. Recognition is based on the hypothesis-and-test paradigm. The detection of an elementary structure allows us to use a signature filter, to hypothesize, and then recursively reduce a set of matching symbols. Hypothesized symbols are then verified by exploiting distance transform and distance measurement.
Synthesis of Le<sup>X</sup>and Le<sup>Y</sup>Oligosaccharides with Azido-Type Spacer-Arms. Comparison of 3- and 4-Methoxybenzyl Groups as Key Temporary Protective Groups (1998)

Abstract 5-Azido-3-oxa-l-pentanol was prepared from 2-(2-chloroethoxy)ethanol and used as a spacer in the chemical synthesis of the trisaccharide β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-GlcNAc and the tetrasaccharide α-L-Fuc-α-(1→2)-β-D-Gal-(1→4)-[α-L-Fuc-(1→3)]-GlcNAc that represent the epitopes defining the human blood groups Lex and Ley. The classical 4-methoxybenzyl group and the remarably acid-stable 3-methoxybenzyl group were compared as temporary protective groups for position 3 at the glucosamine unit to circumvent the problems associated with the simultaneous presence of allyl and azido groups. The resulting oligosaccharides were coupled to proteins with high efficiency. 1 Presented at the VII European Curbohydrate Syposium, Cracow, Poland, August 22–27, 1993.
Pre–existence and emergence of drug resistance in HIV–1 infection (1997)

Antiviral treatment of HIV-1 infection often fails because of the rapid emergence of resistant virus within weeks of the start of therapy. This raises the question of whether resistant viruses pre-exist in drug-naive patients or whether it is produced after the start of therapy. Here we compare the likelihood of pre-existence with the likelihood of production of resistant virus during therapy. We show that provided resistant virus pre-exists, then a stronger therapy may lead to a greater initial reduction of virus load, but will also cause a faster rise of resistant virus. In this case the total benefit of treatment is independent of the degree of inhibition of sensitive virus. If, on the other hand, resistant mutants do not pre-exist, then the emergence of resistance during treatment depends on the efficacy of the drug. If the drug is sufficiently potent to eradicate sensitive virus, then the probability that resistant mutants first appear during therapy is smaller than the probability that they existed before therapy. If the drug cannot eradicate the sensitive virus, then after sufficiently long time resistant mutants will appear. However, mutants that are unlikely to pre-exist may taken long time to appear.
Instant replay using high speed motion capture and projected overlay (2006)

We describe the interactive demonstration 'Instant Replay' to be shown at the Emerging Technologies at Siggraph 2006. Instant Replay is an example application of an inexpensive, highly accurate 'motion capture' system that is able to effectively track many fast-moving, rotating objects. The system works at very high frame rates (500Hz), and reduces cost by employing relatively simple LED projector components in place of high-speed cameras. The cost of the system is only a few hundred dollars.
Patterning a hydrogen-bonded molecular monolayer with a hand-controlled scanning probe microscope (2014)

One of the paramount goals in nanotechnology is molecular-scale functional design, which includes arranging molecules into complex structures at will. The first steps towards this goal were made through the invention of the scanning probe microscope (SPM), which put single-atom and single-molecule manipulation into practice for the first time. Extending the controlled manipulation to larger molecules is expected to multiply the potential of engineered nanostructures. Here we report an enhancement of the SPM technique that makes the manipulation of large molecular adsorbates much more effective. By using a commercial motion tracking system, we couple the movements of an operator's hand to the sub-angstrom precise positioning of an SPM tip. Literally moving the tip by hand we write a nanoscale structure in a monolayer of large molecules, thereby showing that our method allows for the successful execution of complex manipulation protocols even when the potential energy surface that governs the interaction behaviour of the manipulated nanoscale object(s) is largely unknown.
Micronutrient Deficiencies as Predisposing Factors for Hypertension in Lacto-Vegetarian Indian Adults (2004)

Low dietary intakes of vitamin C, folic acid and zinc emerged as the possible risk factors for hypertension. Further, lower levels of plasma vitamin C, erythrocyte membrane zinc and ceruloplasmin were found to be the putative intermediary biomarkers in pathogenesis of hypertension.