gebhart/patrepeval huggingface dataset:
Quality Frameworks for Virtual Care: Expert Panel Recommendations (2022)

Given the significant advance of virtual care in the past year and half, it seems timely to focus on quality frameworks and how they have evolved collaboratively across health care organizations. Massachusetts General Hospital's (MGH) Center for TeleHealth and Mass General Brigham's (MGB) Virtual Care Program are committed to hosting annual symposia on key topics related to virtual care. Subject matter experts across the country, health care organizations, and academic medical centers are invited to participate. The inaugural MGH/MGB Virtual Care Symposium, which focused on rethinking curriculum, competency, and culture in the virtual care era, was held on September 2, 2020. The second MGH/MGB Virtual Care Symposium was held on November 2, 2021, and focused on virtual care quality frameworks. Resultant topics were (1) guiding principles necessary for the future of virtual care measurement; (2) best practices deployed to measure quality of virtual care and how they compare and align with in-person frameworks; (3) evolution of quality frameworks over time; (4) how increased adoption of virtual care has impacted patient access and experience and how it has been measured; (5) the pitfalls and barriers which have been encountered by organizations in developing virtual care quality frameworks; and (6) examples of how quality frameworks have been applied in various use cases. Common elements of a quality framework for virtual care programs among symposium participants included improving the patient and provider experience, a focus on achieving health equity, monitoring success rates and uptime of the technical elements of virtual care, financial stewardship, and clinical outcomes. Virtual care represents an evolution in the access to care paradigm that helps keep health care aligned with other modern industries in digital technology and systems adoption. With advances in health care delivery models, it is vitally important that the quality measurement systems be adapted to include virtual care encounters. New methods may be necessary for asynchronous transactions, but synchronous virtual visits and consults can likely be accommodated in traditional quality frameworks with minimal adjustments. Ultimately, quality frameworks for health care will adapt to hybrid in-person and virtual care practices.
Hepatitis C virus is not a cofactor for Kaposi's sarcoma development in HIV‐infected patients (2006)

SCOPUS: le.j
Long-Range Plasmophore Rulers (2013)

Using on-wire lithography, we studied the emission properties of nanostructures made of a polythiophene disk separated by fixed nanoscopic distances from a plasmonic gold nanorod. The intense plasmonic field generated by the nanorod modifies the shape of the polythiophene emission spectrum, and the strong distance dependence of this modulation forms the basis for a new type of "plasmophore ruler". Simulations using the discrete dipole approximation (DDA) quantitatively support our experimental results. Importantly, this plasmophore ruler is independent of signal intensity and is effective up to 100 nm, which is more than two times larger than any reported value for rulers based on photoluminescence processes.
A Novel DRAM Architecture for Improved Bandwidth Utilization and Latency Reduction Using Dual-Page Operation (2021)

Emerging memory-intensive applications require a paradigm shift from processor-centric to memory-centric computing. The performance of state-of-the-art computing systems and accelerators designed for such applications is not limited by the processing speed but rather by the limited DRAM bandwidth and long DRAM latencies. Although, the interface frequency of new commodity DRAM memories is constantly increasing to achieve a higher peak bandwidth, this bandwidth cannot be fully utilized due to long internal latencies. Page-misses (i.e., change of active row) are one of the key contributors to long access latencies that result in a low bandwidth utilization. In this brief, we propose a novel DRAM sub-array level architecture referred to as Dual-Sense-Amplifier (DSA) that masks the page-miss latency by allowing individual sub-arrays or banks to flexibly open two rows concurrently. Additionally, the DSA architecture design aim to be fully compatible with any type of commodity DRAM architecture (e.g., HBM, GDDR, etc.) and to retain most of its circuit designs. The area overhead of DSA for an 8Gb device is 9.6% compared to a commodity DRAM device. On average, a DSA 8Gb device improves the bandwidth utilization by 17.53% and reduces the average response latency by 31.59 ns compared to commodity DRAM devices operated at 800 MHz. Moreover, we demonstrate that the energy consumption overhead of a DSA DRAM in comparison to a commodity DRAM is negligible.
Biomechanical Signals of Varied Modality and Location Contribute Differently to Recognition of Transient Locomotion (2020)

Intent recognition in lower-limb assistive devices typically relies on neuromechanical sensing of an affected limb acquired through embedded device sensors. It remains unknown whether signals from more widespread sources such as the contralateral leg and torso positively influence intent recognition, and how specific locomotor tasks that place high demands on the neuromuscular system, such as changes of direction, contribute to intent recognition. In this study, we evaluated the performances of signals from varying mechanical modalities (accelerographic, gyroscopic, and joint angles) and locations (the trailing leg, leading leg and torso) during straight walking, changes of direction (cuts), and cuts to stair ascent with varying task anticipation. Biomechanical information from the torso demonstrated poor performance across all conditions. Unilateral (the trailing or leading leg) joint angle data provided the highest accuracy. Surprisingly, neither the fusion of unilateral and torso data nor the combination of multiple signal modalities improved recognition. For these fused modality data, similar trends but with diminished accuracy rates were reported during unanticipated conditions. Finally, for datasets that achieved a relatively accurate (≥90%) recognition of unanticipated tasks, these levels of recognition were achieved after the mid-swing of the trailing/transitioning leg, prior to a subsequent heel strike. These findings suggest that mechanical sensing of the legs and torso for the recognition of straight-line and transient locomotion can be implemented in a relatively flexible manner (i.e., signal modality, and from the leading or trailing legs) and, importantly, suggest that more widespread sensing is not always optimal.
Bending Model of an Integrated SMA Micro-Actuator (2004)

In this paper, we give a model of a Shape Memory Alloy (SMA) thin blade working in bending. This work is based on the general study and modeling of an integrated SMA micro-actuator called the “ module”, controled by thermoelectric effect. This module was developed in two versions. The first one is composed of a NiTi thin blade on which are placed two copper elements which play the role of heat sinks. Its temperature is controlled by Joule effect. In the second version, Bismuth Telluride ingots are used instead of copper elements. This second configuration allows the temperature control of the SMA blade by Peltier effect. The model of the bending behavior is based on a general macroscopic description of the thermomechanical behavior of SMA. The self-accommodating (pure thermal effect) and oriented (stress-induced) martensites are taken into account. The thermal boundary conditions used in this paper correspond to the first version of the micro-actuator. The numerical resolution by finite differences leads to the comprehension of phase transformation for pseudo-elastic and thermal cycling bending tests.
New Ecological Concrete that Reduces CO2 Emissions Below Zero Level ∼ New Method for CO2 Capture and Storage ∼ (2013)

We have developed a new ecological concrete which can achieve a CO2 emission level below zero by capturing CO2. This concrete is based on two typical features. One of the features of this concrete is using a special admixture (the γ phase of dicalcium silicate: γ-2CaO.SiO2) instead of cement. This material has a very low level of CO2 emissions and hardens the concrete by reacting with CO2. The other feature of this concrete is capturing the CO2 contained in the exhaust gas from thermal power stations. In this paper, we set forth the concepts of the development and various results of examination of the ecological concrete. This ecological concrete is named CO2-SUICOM (CO2 Storage under Infrastructure by Concrete Materials).
Risk averse energy management strategy in the presence of distributed energy resources considering distribution network reconfiguration: an information gap decision theory approach (2019)

Distributed energy resources (DERs) and distribution network reconfiguration have considerable effects on both the economic and operational performance of distribution networks. However, the uncertain nature of renewable energy sources (RESs), wind energy, for instance, can bring about serious challenges to the distribution system operators and distribution companies (DisCos). Therefore, a suitable methodology is a matter of the utmost importance to handle the uncertainty of RESs. In addition, DisCos can benefit from the utilisation of energy storage technologies to increase the penetration of RESs into the system. In this regard, this study proposes a risk‐averse energy management strategy (RA‐EMS) in the presence of DERs, while the impact of uncertainties of RESs on the optimal configuration of the network is investigated. The uncertainty of RESs is modelled through the information gap decision theory, which has significant advantages such as low computational burden, no need for probability density function, and exact results compared to other methodologies for uncertainty handling. The proposed RA‐EMS model is implemented on the IEEE 33‐bus distribution system, and its superiority over the scenario‐based stochastic programming is demonstrated. The robust configuration of the system against RESs’ uncertainty is obtained for different levels of uncertainty radius.
The Practice of Venous Thromboembolism Prophylaxis in the Major Trauma Patient (2007)

Clinicians are reticent to begin timely VTE prophylaxis in critically injured patients. Patients are without VTE prophylaxis for half of all days within the first week of admission and this delay in the initiation of prophylaxis is associated with a threefold greater risk of VTE. The relative risks and benefits of early VTE prophylaxis need to be defined to better direct practice in this high-risk population.
Auger recombination in low-band-gap <i>n</i>-type InGaAs (2001)

We measured the recombination lifetime of degenerate n-InxGa1−xAs for three different compositions that correspond to x=0.53, 0.66, and 0.78 (band gaps of 0.74, 0.60, and 0.50 eV, respectively) over the doping range of 3×1018–5×1019 carriers/cm3. The Auger recombination rate increases slowly with decreasing band gap, and it matches the behavior predicted for phonon-assisted recombination.
Factorized Point Based Global Illumination (2013)

Abstract The Point‐Based Global Illumination (PBGI) algorithm is composed of two major steps: a caching step and a multiview rasterization step. At caching time, a dense point‐sampling of the scene is shaded and organized in a spatial hierarchy, with internal nodes approximating the radiance of their subtrees using spherical harmonics. At rasterization time, a microbuffer is instantiated at the unprojected position of each image pixel (receiver). Then, a view‐adaptive level‐of‐detail of the scene is extracted in the form of a tree cut and rasterized in the receiver's microbuffer, solving for visibility using a local variant of the z‐buffer. Finally, the pixel color is computed by convolving its filled microbuffer with the surface BRDF. This noise‐free indirect lighting method is widely used in the industry and captures several critical lighting effects, including ambient occlusion, color bleeding, (indirect) soft‐shadows and environment lighting. However, we observe a large redundancy in this algorithm, both in cuts and receivers'microbuffers, which stems from their relatively low resolution. In this paper, we propose an evolution of PBGI which exploits spatial coherence to reduce these redundant computations. Starting from a similarity‐based variational clustering of the receivers, we compute a single tree cut and rasterize a single microbuffer for each cluster. This per‐cluster microbuffer provides a faithful approximation of the incident radiance for distant nodes and is composited over a receiver‐specific microbuffer rasterizing only the closest nodes of the cluster's cut. This factorized approach is easy to integrate in any existing PBGI implementation and offers a significant rendering speed‐up for a negligible and controllable approximation error.
Upregulation of the secretory pathway in cysteine protease inhibitor-resistant <i>Trypanosoma cruzi</i> (2000)

A novel chemotherapy in development for Chagas' disease targets cruzain, the major cysteine protease of Trypanosoma cruzi. Peptidomimetic inhibitors disrupt the intracellular cycle of the parasite and rescue animals from a lethal infection. Inhibitor killing of parasites results from interruption of autocatalytic cruzain processing and transport to lysosomes, and massive accumulation of precursor protein in the Golgi complex. To further understand the mechanisms of protease processing and transport in this primitive eukaryote, and uncover potential mechanisms for resistance to these drugs, we generated cysteine-protease inhibitor (CPI)-resistant epimastigotes in vitro and investigated the mechanisms involved at the biochemical and structural levels. Resistance to 20-fold the lethal CPI concentration, achieved after a year of gradual drug increase, was accompanied by a modest decrease in growth rate. A marked increase in the number of vesicles trafficking from the Golgi complex to the flagellar pocket occurs in resistant cells. No mature protease reaches lysosomes though accumulation of endocytosed gold particles in lysosomes appears to be normal. Higher molecular mass cruzain species, consistent with complexes of cruzain precursors and inhibitor, are secreted by CPI-resistant parasites into the culture supernatant. Release of these cruzain precursors may be facilitated by an enhanced acidification of trans-Golgi cisternae in resistant parasites. The pH within Golgi cisternae is higher in control epimastigotes and most mature cruzain is lysosomal. Cruzain activity is negligible in CPI-resistant epimastigote extracts compared to the parental clone. Activity is restored following withdrawal of the inhibitor. No cross-resistance to the therapeutic drugs nifurtimox and benznidazole occurred and, conversely, parasites resistant to these drugs were sensitive to CPI. Protease inhibitors are thus potential therapeutical alternatives in cases of nifurtimox/benznidazole resistance. Cumulatively, these results suggest that CPI-resistance induces upregulation of Golgi complex function and post-Golgi secretory pathway, and release of precursors before the enzyme reaches its site of biologic activity.
General Integral Formulation of Magnetic Flux Computation and Its Application to Inductive Power Transfer System (2017)

An accurate and fast post-processing method for computing the magnetic flux through a coil is discussed and applied to the analysis of inductive power transfer (IPT) systems. This post-processing method is well adapted to various numerical methods. In this paper, a volume integral method based on magnetic vector potential interpolation is focused to solve the computational magnetostatic problem for the field quantities. It does not require the discretization of the predominant air domain, so is perfectly suited for the modeling of IPT couplers. In magnetostatic analysis, the magnetic flux is expressed as a summation of two terms. The first one is created by source coils and is computed by integral expressions. The second one is obtained by a light integration only on the magnetic region. The method is accurate and associated with a reduced computation time. It is compared with both finite-element method and experimental results to check its performance.
Differential activity of ARRY-543, a potent, small molecule inhibitor of EGFR/ErbB-2 compared to lapatanib in in vivo xenograft models (2008)

4848 ARRY-543 is an orally active, potent small molecule tyrosine kinase inhibitor targeting both EGFR and ErbB2. The compound is a reversible, ATP-competitive inhibitor with nanomolar potency in both in vitro and in cell-based assays. This compound has very good in vivo and in vitro PK/ADME properties and has shown excellent activity in numerous mouse tumor models. In a series of experiments, we show that ARRY-543 has superior activity to lapatinib in several subcutaneous human tumor xenograft models selected for EGFR and ErbB2 expression patterns: A431, H1650 and N87. A431 is a wild-type EGFR-overexpressing epidermoid carcinoma cell line. H1650 is an EGFR overexpressing, lung adenocarcinoma cell line, which has the Exon 19 deletion conferring increased sensitivity to gefitinib and erlotinib. N87 is a gastric carcinoma cell line expressing high levels of both EGFR and ErbB2 and also relies on both for proliferation and survival. For all tumor studies, female nude mice were inoculated with cells subcutaneously in the flank. For tumor growth inhibition (TGI) studies, tumor size was measured at regular intervals for up to 21 days. In the A431 TGI study, ARRY-543 demonstrated significant dose-related TGI; 30, 57 and 81% at doses of 25, 50 and 100 mg/kg, BID, PO, respectively. Lapatinib administration at 50 and 100 mg/kg, BID, PO showed 33 and 52% TGI, respectively. In the H1650 TGI study, animals received oral doses of vehicle, ARRY-543 or lapatinib (100 mg/kg, BID) or erlotinib (100 mg/kg, QD). ARRY-543 demonstrated significant tumor growth inhibition (95%), with 2/8 animals showing tumor regressions. Comparable tumor growth inhibition was seen in the erlotinib group; 6/8 animals with tumor regressions. Lapatinib showed significantly less activity with respect to tumor growth inhibition (~18%; NS); no tumor regressions were observed. In the dual EGFR/ErbB2-over-expressing gastric carcinoma tumor line N87, pharmacodynamic studies were performed evaluating the effects of vehicle, ARRY-543 (100 mg/kg, once) or lapatinib (100 mg/kg, once) on pEGFR and pErb2 levels in tumors at 4 and 12 hrs. post-dose. ARRY-543 inhibited the phosphorylation of both receptors at both timepoints with significant inhibition (~70%) of both receptors at 12 hrs. In a separate study, this level of inhibition resulted in profound TGI. Lapatinib showed mild inhibition (NS) of both receptors at 4 hours post-dose (15-30%) and no effects at the 12 hours post-dose timepoint. These studies demonstrate that ARRY-543 has superior activity over lapatinib with respect to TGI and/or PD effects (extent and duration) on the EGFR and ErbB2 receptors in preclinical mouse tumor models. ARRY-543 is entering Phase II trials in select cancer patient populations.
Supplementary Tables 1-10, Figures 1-6, Methods from Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression (2023)

Supplementary Tables 1-10, Figures 1-6, Methods from Frequent Attenuation of the WWOX Tumor Suppressor in Osteosarcoma Is Associated with Increased Tumorigenicity and Aberrant RUNX2 Expression
An Explainable Knowledge Completion Model Using Explanation Segments (2021)

최근 딥러닝을 활용하여 불완전한 지식 그래프를 대상으로 새로운 링크를 예측하는 연구가 많이 진행되고 있지만, 딥러닝을 활용한 링크 예측은 추론 결과에 대한 설명이 불가능하다는 한계점이 있다. 따라서 본 논문에서는 링크 예측 후, 추론 결과를 뒷받침하는 증거로서 설명 가능한 추론 경로를 제공하여 지식 완성의 효용성이 높은 모델을 제안한다. 이를 위해 우선 지식 그래프의 주어를 시작으로 목적어로 도달하는 또 다른 경로를 Path Ranking Algorithm 활용하여 생성하며, 이를 explanation segment라 정의하였다. 이 후 생성된 explanation segment를 CNN과 양방향 LSTM을 결합한 방식을 적용하여 임베딩 한다. 마지막으로 임베딩 된 explanation segment들과 추론할 후보 술어와의 의미적 유사성 계산을 기반으로 한 어텐션 메커니즘을 적용하여, 링크 예측 모델을 학습하였다. 모델 학습 후 링크 예측 설명에 적합한 explanation segment를 어텐션 점수에 기반으로 선정하여 제공한다. 제안하는 방법의 성능을 측정하기 위해 링크 예측 비교 실험 및 링크 예측 결과에 대한 설명으로 적합한 explanation segment의 비율을 측정하는 정확성 검증 실험을 진행하였다. 실험 데이터는 벤치마크 데이터인 NELL-995, FB15K-237, Countries를 대상으로 진행하였으며, 정확성 검증 실험에서 평균 89%. 44%, 97% 정확성을 보였고, 기존 연구와 비교했을 때, NELL-995는 평균 35%p, FB15K-237은 평균 21%p 높은 성능을 보였다.
Efficient cleavage of carbon graphene layers by oxidants (1995)

The graphene layers at carbon nanotube cap regions are efficiently cleaved by several oxidants (e.g., KMnO4, OsO4 and RuO4) in acidic solution at 100 °C, but not by stronger oxidants, such as K2Cr2O7–H+ and H2O2–H+.
Liposomal delivery of horseradish peroxidase for thermally triggered injectable hyaluronic acid–tyramine hydrogel scaffolds (2015)

A thermoresponsive injectable hydrogel scaffold for tissue engineering has been developed, whereby the scaffold was injected as a liquid at room temperature, and gelled at the target site in response to the change in body temperature. Our approach involved suspending thermoresponsive liposomes, which encapsulated horseradish peroxidase (HRP), in a hyaluronic acid-tyramine (HA-Tyr) conjugate and hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) solution. At room temperature, HRP was separated from the HA-Tyr conjugate by the lipid membrane, and hence the precursor solution remained as a liquid and was injectable. Upon injection and exposure to body temperature, the lipids experienced a phase transition, which significantly increased the membrane permeability and led to the release of HRP and the oxidative coupling of Tyr moieties with H<sub>2</sub>O<sub>2</sub>, forming a crosslinked hydrogel scaffold. It was shown in this study that the precursor solution remained as a liquid on the order of hours at 20 °C, yet gelation could be induced within minutes by heating to 37 °C. Furthermore, it was shown that HRP release could be controlled by various material and processing parameters, and that the gelation rate could be adjusted to meet various clinical needs by adjusting HRP encapsulation, liposome concentration and HA-Tyr concentration.
Publisher’s Note: Visual Observation of Zener Tunneling [Phys. Rev. Lett.<b>96</b>, 023901 (2006)] (2006)

Received 20 January 2006DOI:https://doi.org/10.1103/PhysRevLett.96.039906©2006 American Physical Society
Eliminating Structural Loss in Optomechanical Resonators Using Elastic Wave Interference (2013)

We theoretically and experimentally demonstrate that the support loss of double-disk optomechanical resonators can be minimized using destructive elastic wave interference. We show 100MHz Si3N4 resonators with mechanical quality factor of 104 at room temperature.
Design of a wedge-shaped folded structure (2010)

The prospects of the application of four-beam modified and unmodified folded structures in sandwich panels for aviation, transport, and construction are investigated. It is shown that folded wedge-shaped blocks can possibly be formed by changing the marking parameters. The basic geometrical relations are determined.
Neuropathology of the Olfactory Mucosa in Chronic Rhinosinusitis (2010)

Our results suggest that OM pathology observed in nasal biopsy specimens can assist in understanding the degree of epithelial change and sensorineural damage in CRS and the potential for olfactory loss.
Surfaces That Sequester Serum‐Borne Heparin Amplify Growth Factor Activity (2011)

Surfaces presenting a heparin-binding peptide can non-covalently sequester heparin from culture supplements, such as fetal bovine serum. In turn, sequestered, serum-borne heparin can non-covalently localize growth factors at the cell-material interface, resulting in amplified growth factor bioactivity.