gebhart/patrepeval huggingface dataset:
Anomalous Phenomena Occurring during Permeation and Sorption of C<sub>1</sub>–C<sub>6</sub> Alcohol Vapors in Teflon AF 2400 (2013)

This paper reports on the anomalous diffusion of C1–C6 alcohol vapors in the high-free-volume, amorphous glassy perfluoropolymer Teflon AF 2400. In this material, during time lag measurements, the transient in the pressure increase curve of aliphatic alcohols exhibits a quite unusual behavior, different from the previously reported diffusion of permanent gases and that of other vapors (such as hydrocarbons, acetone, dichloromethane, etc.). Such unusual behavior can be explained by the simultaneous diffusion of dynamic molecular aggregates: clusters, made of at least two or three molecules with different diffusion coefficients, differing in orders of magnitude from those of single molecules. The probability of cluster formation increases at higher C1–C6 alcohol vapor activities. Moreover, the average cluster size decreases from methanol to pentanol with increasing molecular size, because of the longer hydrocarbon chain and, consequently, the lower polarity. Weak (butanol, pentanol) and almost zero (hexanol) clustering ability in Teflon AF 2400 was confirmed independently by the ENSIC model and through evaluation of diffusion from gravimetric sorption experiments in the vapor activity range (0.15–0.95). In addition, we present a novel method for the treatment of raw sorption kinetic data recorded by a gravimetric sorption apparatus equipped with a calibrated quartz (McBain’s) spiral balance. The mentioned treatment allows one to eliminate overlapping mechanical oscillations of the spiral balance (caused by the initial charging of the sample gas/vapor into the evacuated measuring chamber) and successfully reconstruct the real elongation of the spiral caused by gas/vapor sorption into a polymer material. This allows to calculate accurate values of the gas/vapor diffusion coefficients, even from highly noisy sorption data.
Fluorescence Lifetime Correlation Spectroscopy Combined with Lifetime Tuning:  New Perspectives in Supported Phospholipid Bilayer Research (2006)

A new concept based on fluorescence lifetime correlation spectroscopy (FLCS) is presented allowing the simultaneous determination of diffusion coefficients of identical molecules located in different environments. The difference in fluorescence lifetimes, which is the main prerequisite for FLCS, is reached by locating one population of the dye close to a light-absorbing surface. Since such surfaces quench fluorescence, the fluorescence lifetime of chromophores located close to these surfaces can be tuned in a specific manner. This approach has been demonstrated for a BODIPY-tail-labeled lipid in supported phospholipid bilayers (SPBs) as well as in phospholipid multilayers adsorbed onto solid supports. In particular, the effect of the solid support type on the fluorescence lifetime as well as its dependence on the BODIPY-support distance has been characterized and verified by theoretical considerations based on precise determination of refractive indices of the used supports. While the fluorescence lifetime of BODIPY dye is 5.6 ns in small unilamellar vesicles (SUVs) composed of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-[phospho-L-serine] (DOPS), the lifetime is 1.8 ns in DOPC/DOPS SPBs adsorbed onto ITO-covered glass or 3.0 ns in a DOPC/DOPS monolayer adsorbed onto seven 1,2-dipalmitoyl-sn-glycero-3-phosphate (DPPA) layers on oxidized silicon. Using these particular systems, we demonstrated that FLCS enables one to characterize simultaneously two-dimensional lipid diffusion in the planar lipid layers and three-dimensional vesicle diffusion in bulk above the lipid layers using single dye labeling. The autocorrelation functions obtained by this new approach do agree with those obtained by standard FCS on isolated SPBs or vesicles. Possible applications of this virtual two-channel measurement using single dye labeling as well as one detection channel are discussed.
The Constrained Vapor Bubble (CVB) Experiment in the Microgravity Environment of the International Space Station (2011)

The Constrained Vapor Bubble (CVB) experiment was run in the microgravity environment of the International Space Station as part of the Increment 23-24 which ended in September 2010. Here we present preliminary results which indicate significant differences in the operation of the CVB heat pipe in the micro-gravity environment as compared to the Earth's gravity. The temperature profile data along the heat pipe indicate that the heat pipe behavior is affected favorably by increased capillary flow and adversely by the absence of convective heat transfer as a heat loss mechanism. Image data of the liquid profile in the grooves of the heat pipe indicate that the curvature gradient is considerably different from that on Earth. An initial discussion of the data collected is presented.
Real Time Tracking of Multiple Persons on Colour Image Sequences (2005)

International audience
Modified Linear Peptides Effectively Silence STAT-3 in Breast Cancer and Ovarian Cancer Cell Lines (2023)

RNA interference (RNAi) has drawn enormous attention as a powerful tool because of its capability to interfere with mRNA and protein production. However, designing a safe and efficient delivery system in RNAi therapeutics remains challenging. Herein, we have designed and synthesized several linear peptides containing tryptophan (W) and arginine (R) residues separated by the β-alanine (βA) spacer and attached to a lipophilic fatty acyl chain, cholesterol, or PEG. The peptide backbone sequences were: Ac-C-βA-βA-W<sub>4</sub>-βA-βA-R<sub>4</sub>-CO-NH<sub>2</sub> and Ac-K-βA-βA-W<sub>4</sub>-βA-βA-R<sub>4</sub>-CO-NH<sub>2</sub>, with only a difference in <i>N</i>-terminal amino acid. The cysteine side chain in the first sequence was used for the conjugation with PEG2000 and PEG550. Alternatively, the side chain of lysine in the second sequence was used for conjugation with cholesterol or oleic acid. We hypothesized that amphiphilic peptides and optimum fatty acyl chain or PEG could function as an effective siRNA carrier by complementing each structural component's self-assembly and membrane internalization properties. None of the designed peptides showed cytotoxicity up to 10 µM. Serum stability studies suggested that the newly designed peptides efficiently protected siRNA against early degradation by nucleases. Flow cytometry analysis indicated 50-90% cellular uptake of siRNA using the newly developed modified linear peptides (MLPs). Western blot results revealed more than 90% protein downregulation after targeting STAT3 in MDA-MB-231 and SKOV-3 cell lines. In summary, a new peptide class was developed to safely and efficiently deliver siRNA.
Evaluation of safety and effectiveness of cryoablation in the treatment of renal angiomyolipoma related to tuberous sclerosis complex: The Cryo-TSC study. (2022)

TPS397 Background: Tuberous sclerosis complex (TSC) is an autosomal dominant inherited disease that causes benign tumors called hamartoma all over the body as well as neuropsychiatric symptoms such as epilepsy. One-third of patients have a family history of the disease, but the remaining two-thirds are solitary cases and are caused by newly arising mutations. The TSC1 gene on chromosome 9 and TSC2 on chromosome 16 have been identified as the causative genes. Approximately 60%–80% of patients with TSC have renal lesions, and angiomyolipoma (AML) occurs bilaterally. The frequency of TSC-associated AML (TSC-AML) increases with age, reaching 60%–80% in adults, and the rate of death from renal disease increases with age in TSC patients. The current standard of care for AML is arterial embolization or surgery (partial nephrectomy or nephrectomy), but TSC is a hereditary disease and AMLs occur one after another with age. Repeated surgical procedures are technically difficult, and arterial embolization has a high recurrence rate. Under these circumstances, an mTOR inhibitor, everolimus, has shown a marked reduction of TSC-AML and is widely used. However, everolimus must be administered permanently because AML re-occurs after discontinuation of everolimus. Cryotherapy has been used as a treatment for renal tumors, and there have been some reports of cryotherapy for solitary AML, but the safety and efficacy of cryotherapy for TSC-AML have not been established. Therefore, we planned this study to establish the safety and efficacy of cryotherapy for TSC-AML. Methods: This is an open-label, single-arm, phase II study to evaluate the safety and efficacy of cryotherapy for TSC-AML of 4 cm or less in patients with 16 years of age or older. The exclusion criteria are an inability to withdraw from mTOR inhibitor and failure to maintain rest during cryotherapy. mTOR inhibitor medication should be withdrawn at least 7 days prior to cryotherapy and discontinued during the study period. Cryotherapy will be performed using Cryohit (GALIL MEDICAL LTD, Israel). Safety will be assessed at 1, 2, 6, and 9 months after cryotherapy, and efficacy will be assessed at 3 and 9 months after cryotherapy. The efficacy of cryotherapy will be evaluated according to modified RECIST or RECIST criteria. The primary endpoint will be the disease control rate of AML treated with cryotherapy, and secondary endpoints will be the overall response rate, safety, renal function, quality of life, and whether additional treatment is required. Clinical trial information: jRCTs072200039.
Gut Microbiota-Generated Phenylacetylglutamine and Heart Failure (2022)

URL: https://clinicaltrials.gov/; Unique identifier: NCT00590200 and URL: https://drks.de/drks_web/; Unique identifier: DRKS00020915.
Bosniak Category IIF Designation and Surgery for Complex Renal Cysts (2009)

Adding the IIF category has increased the accuracy and clinical impact of the Bosniak categorization system, as evidenced by a low rate of progression in category IIF cysts and an increased rate of malignancy in surgically treated category III lesions compared to those in historical controls.
Ischemia-reperfusion-inducible protein modulates cell sensitivity to anticancer drugs by regulating activity of efflux transporter (2009)

Human ischemia-reperfusion-inducible protein (hIRIP) or hYrdC belongs to the SUA5/YrdC/YciO protein family and affects activity of a variety of cellular transporters. We observed that overexpression of wild-type or dominant-negative mutant of hIRIP protein affects the cellular sensitivity to anticancer drugs with different mechanisms of toxicity. Here we investigated in detail the effect of hIRIP on cell sensitivity to doxorubicin and show that hIRIP inhibits the drug efflux. Multidrug-resistant P-glycoprotein was identified as one of the target transporters. IRIP does not influence P-glycoprotein biosynthesis but affects its processing and promotes degradation. We also show that P-glycoprotein is associated with COP-alpha, one of the proteins of the COPI complex. This interaction is sensitive to the level of hIRIP expression. These findings suggest that hIRIP expression can regulate cargo assembly and function of efflux transporters, including P-glycoprotein, which mediates one of the most common mechanisms of the multidrug resistance.
Potential for the Rational Design of Allosteric Modulators of Class C GPCRs (2016)

Class C G protein-coupled receptors encompass a range of promising therapeutic targets for a variety of diseases, yet to date only two members of this sub-family of GPCRs have been drugged. Recent advances in structural biology have revealed the X-ray crystallographic structures of allosteric ligands bound to two Class C metabotropic glutamate (mGlu) receptors, mGlu1 and mGlu5. Herein, we review how this information can be leveraged to help understand some of the historical challenges of mGlu receptor allosteric modulator drug discovery, and discuss how the structural enablement can be prospectively used for structurebased drug discovery approaches across Class C GPCR targets in general.
Enhancement of DNA vaccine potency through linkage of antigen to filamentous bacteriophage coat protein III domain I (2006)

Although DNA-based cancer vaccines have been successfully tested in mouse models, a major drawback of cancer vaccination still remains, namely that tumour antigens are weak and fail to generate a vigorous immune response in tumour-bearing patients. Genetic technology offers strategies for promoting immune pathways by adding immune-activating genes to the tumour antigen sequence. In this work, we converted a model non-immunogenic antigen into a vaccine by fusing it to domain I of the filamentous bacteriophage coat protein III gene. Vaccination with a DNA construct encoding the domain I fusion generated antigen-specific T helper 1-type cellular immune responses. These results demonstrate that the incorporation of protein III into a DNA vaccine formulation can modulate the gene-mediated immune response and may thus provide a strategy for improving its therapeutic effect.
Dressing Materials in the STSG Donor Site Management: A Comparative Study (2004)

Split-thickness skin graft is a frequent, necessary method of treatment in burn patients. After harvesting a split thickness skin graft, there is a variety of options in the post-operative management of the donor site created. Dressing materials provide an occlusive and wet environment and aids in superior wound healing. Of the commercially available dressing materials, Medifoam(R), Allevin(R) and Polymem(R) are the most commonly used materials during the early phases of epithelization. Medifoam-B(R) is a more absorbant dressing material compared to other dressing materials. Its swelling ratio is 1200% and it contains a layer of wound promoters and antibiotics. The purpose of this study is to compare medifoam-B(R), Allevyn(R) and Polymem(R) in the healing time, infection rate, absorption ratio and pain degree. This study is based on 30 patient who underwent split-thickness skin graft in Hanil General Hospital from March 2002 to July 2002. All skin grafts were harvested with an electric dermatome, with a thickness depth of 0.012 to 0.016 inches. Three divisions of each donor site was managed separately with each different materials through postoperative days 0 to 1. Absorption property, infection rate, pain degree, time to complete epithelization were assessed. Medifoam-B(R) performed superior to Allevyn(R), Polymem(R). In conclusion, We suggest Medifoam-B(R) as a useful alternative in the management of the split-thickness donor site wound in the early phases.
ChemInform Abstract: The Synthesis of Some Novel N‐Chloro‐δ1‐4‐azasteroids by Efficient N‐Chlorination of Azasteroid Lactams with Trichloroisocyanuric Acid. (1992)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Differential Gene Expression Profiles in G <sub>1</sub> and S Phase Synchronized Jurkat T Cell Leukemia Cells: Investigation Using an Expressed Sequence Tag Analysis (1996)

The expressed sequence tag (EST) strategy is a useful approach for describing gene diversity and identifying changes in expression patterns between different populations of cells. We constructed two directionally cloned cDNA libraries from human Jurkat T cell leukemia cells synchronized in either the G1 or the S phase of the cell cycle. Sequence analysis of 3398 randomly selected clones from G1 phase and 3428 randomly selected clones from S phase was carried out for the purpose of comparing gene expression profiles. EST sequencing identified 1728 distinct transcripts from the G1 phase library and 1623 distinct transcripts from the S phase library. Approximately 13% of these transcripts appeared to be differentially expressed between the G1 and S phases of the cell cycle. Among the differentially expressed genes were alpha k-1 tubulin, alpha enolase, CDC p55, and ubiquitin. The human homologue of cyclin B2 is also differentially expressed in the G1 phase vs the S phase of the cell cycle. Northern blot analysis of mRNA levels in cells from either the G1 or S phase of the cell cycle correlated well with the quantitation of mRNA from EST profile analysis.
Chemorheological analysis and model-free kinetics of acid catalysed furfuryl alcohol polymerization (2007)

The complete curing of furfuryl alcohol (FA), was studied by chemorheological analysis and model-free kinetics under isothermal and non-isothermal modes. Polymerization of FA under acidic catalysis involves complex reactions, with several steps (such as condensations and Diels-Alder cycloadditions). To account for the polymerization complexity, kinetic analysis of DSC data was performed with a model-free isoconversional method. The obtained E(alpha)-dependencies were closely-correlated with the variation of complex viscosity during curing. Linear condensations are predominant during the early curing stage and are followed by two distinct stages of branching cycloadditions. Gelation and vitrification, identified by rheometric measurements, were associated with a decrease of the overall reaction rate that becomes controlled by diffusion of small oligomers. Before vitrification, the rate of crosslinking is limited by the mobility of longer polymer chains and diffusion encounters a large energy barrier due to the cooperative nature of the motions, leading to higher E(alpha) values.
High performance semantic factoring of giga-scale semantic graph databases. (2010)

As semantic graph database technology grows to address components ranging from extant large triple stores to SPARQL endpoints over SQL-structured relational databases, it will become increasingly important to be able to bring high performance computational resources to bear on their analysis, interpretation, and visualization, especially with respect to their innate semantic structure. Our research group built a novel high performance hybrid system comprising computational capability for semantic graph database processing utilizing the large multithreaded architecture of the Cray XMT platform, conventional clusters, and large data stores. In this paper we describe that architecture, and present the results of our deploying that for the analysis of the Billion Triple dataset with respect to its semantic factors, including basic properties, connected components, namespace interaction, and typed paths.
Polynomial Time Algorithm Solving the Refutation Tree Problem for Formal Graph Systems (1994)

The refutation tree problem for a formal graph system (FGS) is to compute a refutation tree which represents the logical structure of a graph generated by the FGS. We present three subclasses of FGSs: simple FGSs, size-bounded simple FGSs, and bounded simple FGSs. We give a polynomial-time algorithm solving the refutation tree problem for simple FGSs. For sizebounded simple FGSs generating undirected trees of constantly bounded valence, we show that a refutation tree of a graph definable by the FGS can be computed in NC^2. Moreover, we indicate that the refutation tree problem for bounded simple FGSs is in NC^2.
A new multiple-antenna-port and multiple-user-port antenna tuner (2015)

A new multiple-antenna-port and multiple-user-port antenna tuner has the structure of a multidimensional π-network. It is shown that it is able to provide decoupling and matching in the presence of strong variations in the electromagnetic characteristics of the volume surrounding the antennas.
Supplementary Material and Methods from Transposon Mutagenesis Reveals Fludarabine Resistance Mechanisms in Chronic Lymphocytic Leukemia (2023)

&lt;p&gt;Supplementary Material and Methods in Word format&lt;/p&gt;
[Hemodynamic difference accounted for the orientation of a Björk-Shiley mitral prosthesis: a color Doppler echocardiographic study]. (1992)

To determine whether the orientation of the major orifice of a mitral tilting disc prosthesis affects hemodynamics, intracavitary blood flow patterns were studied in 45 patients with well-functioning Björk-Shiley mitral prosthesis using color Doppler flow imaging. The major orifice was oriented towards the septum in 23 patients (12 men, 11 women, age 58 +/- 11 years; group S), and towards the posterior wall in 22 patients (8 men, 14 women, age 55 +/- 9 years; group P). 1) The left ventricular end-diastolic dimensions (S: 4.8 +/- 0.9 cm, P: 5.2 +/- 1.0 cm), end-systolic dimensions (S: 3.6 +/- 0.9 cm, P: 3.8 +/- 1.2 cm), and left atrial dimensions (S: 5.0 +/- 1.0 cm, P: 4.7 +/- 0.9 cm) did not differ significantly between the 2 groups. 2) The peak mitral flow velocities (S: 1.43 +/- 0.38 m/sec, P: 1.43 +/- 0.27 m/sec), pressure gradients (S: 8.5 +/- 4.0 mmHg, P: 8.4 +/- 3.1 mmHg), and pressure half-times (S: 94.0 +/- 19.0 msec, P: 86.5 +/- 21.7 msec) did not differ significantly between the 2 groups. 3) Although mitral regurgitation was detected in 8 patients (35%) in the S group and in 2 patients (9%) in the P group, hemodynamically significant regurgitation was detected in only 4 patients in the S group (3 mild, one moderate). 4) The patients in the S group had reversed intracavitary blood flow; mitral flow was first directed towards the left ventricular outflow tract during diastole, while the outflow pattern was displaced into the left ventricular inflow tract.(ABSTRACT TRUNCATED AT 250 WORDS)
&lt;title&gt;Detection and clutter rejection in image sequences based on multivariate conditional probability&lt;/title&gt; (1999)

A method of detecting dim targets in highly-cluttered time- varying image sequences is presented, where reliable clutter rejection is achieved by calibrating the multivariate statistics of a small number of generic space-time filters. The targets have sufficiently low SCR that a track-before- detect method is required. For targets where there is little prior information on velocity, a large number of filters is generally required to achieve a high response relative to the background. In the method described here, instead of applying thresholds to individual filters, joint filter statistics are used to estimate conditional threshold exceedance probabilities. A smaller number of more generic filters are applied, which are not finely tuned to targets but which characterize aspects of both targets and clutter. Potential targets are cued based on a non-parametric estimate of the probability of occurrence of similar clutter. Constant false alarm rates are inherent in the method. The method is demonstrated on examples of real forward-looking imagery of the sea surface, where glint is a source of strong clutter. Dim targets are distinguished form clutter by using the joint statistics of three variables: a constant-intensity blob filter, a filter tuned to sea glint flashes, and the vertical image coordinate.
Tissue characterization in medical robotics (2014)

The lack of haptic feedback has negatively affected the surgeon's ability to palpate and diagnose tissue and differentiate its stiffness during surgical operations with commercially available robotic assisted surgical systems. A modular surgical instrument capable of non-invasive measurement of sideways tip/tissue interaction forces for direct application in robotic assisted minimally invasive surgery systems is presented in this paper. The proposed force measurement technique enables the actual non-invasive measurement of the sideways interaction forces at the tip jaws. The instrument has two actuation degrees of freedom (DOF) for the tip operation and grasping orientation. The tip functionality type (e.g., grasping, cutting, and dissecting) can also be changed quickly and easily. Experiments were conducted to evaluate functionalities of the proposed instrument in palpating tissues. The results are presented and analysed here that verify the capability of the proposed instrument in accurately measuring lateral tip/tissue interaction forces.