gebhart/patrepeval huggingface dataset:
Identification of Frequency-Dependent Parameters in a Flexible Rotor System (2005)

In a rotor-bearing system, there are usually some under- or unmodeled dynamic components that are considered frequency dependent, such as foundations, bearings, and seals. This paper presents a method to identify the dynamic behavior of these components using an otherwise accurate engineering model of the system in combination with available measurements of system frequency response functions. The approach permits treatment of flexible rotors and allows that the system test excitations and measurement sensors are not collocated. Because all engineering models contain some residual error and all measurements incorporate an element of noise or uncertainty, the quality of the identified parameters must be estimated. This paper introduces application of μ analysis to solve this problem, resulting in acceptable solution time and hard guarantees of solution reliability. Two illustrative examples are provided, showing that the presented approach is an efficient method to identify and bound these parameters.
Data Supplement from A Search for Novel Cancer/Testis Antigens in Lung Cancer Identifies VCX/Y Genes, Expanding the Repertoire of Potential Immunotherapeutic Targets (2023)

&lt;p&gt;Supplementary Table S5. Prediction of binding affinity to HLA molecules in BIMAS and SYFPEITHI.&lt;/p&gt;
ChemInform Abstract: Synthesis of Unsymmetrical Biaryls via “Kinetic” Higher Order Cyanocuprates: Scope, Limitations, and Spectroscopic Insights. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The SMARTER pilot study: Testing feasibility of real-time feedback for dietary self-monitoring (2017)

Self-monitoring (SM) of food intake is central to weight loss treatment. Technology makes it possible to reinforce this behavior change strategy by providing real-time feedback (FB) tailored to the diary entry. To test the feasibility of providing 1-4 daily FB messages tailored to dietary recordings via a smartphone, we conducted a 12-week pilot randomized clinical trial in Pittsburgh, PA in US in 2015. We compared 3 groups: SM using the Lose It! smartphone app (Group 1); SM + FB (Group 2); and SM + FB + attending three in-person group sessions (Group 3). The sample (N = 39) was mostly white and female with a mean body mass index of 33.76 kg/m<sup>2</sup>. Adherence to dietary SM was recorded daily, weight was assessed at baseline and 12 weeks. The mean percentage of days adherent to dietary SM was similar among Groups 1, 2, and 3 (p = 0.66) at 53.50% vs. 55.86% vs. 65.33%, respectively. At 12 weeks, all groups had a significant percent weight loss (p < 0.05), with no differences among groups (- 2.85% vs. - 3.14% vs. - 3.37%) (p = 0.95); 26% of the participants lost ≥ 5% of their baseline weight. Mean retention was 74% with no differences among groups (p = 0.37). All groups adhered to SM at levels comparable to or better than other weight loss studies and lost acceptable amounts of weight, with minimal intervention contact over 12 weeks. These preliminary findings suggest this 3-group approach testing SM alone vs. SM with real-time FB messages alone or supplemented with limited in-person group sessions warrants further testing in a larger, more diverse sample and for a longer intervention period.
Neuroleptic‐Induced Supersensitivity and Brain Iron: I. Iron Deficiency and Neuroleptic‐Induced Dopamine D<sub>2</sub> Receptor Supersensitivity (1990)

Previous studies have shown that nutritional iron deficiency in rats reduces brain iron content, resulting in dopamine D2 receptor subsensitivity, as indicated by a decrease in [3H]spiperone binding in caudate nucleus and in behavioral responses to apomorphine. Both phenomena can be reversed by iron supplementation. The possibility that neuroleptic-induced dopamine D2 receptor supersensitivity involves an alteration in brain iron content was investigated in nutritionally iron-deficient and control rats chronically treated with haloperidol (5 mg/kg daily for 14 or 21 days). Neuroleptic treatment was initiated either (a) concurrently with iron deficiency or (b) 2 weeks after the start of iron deficiency. The results show that dopamine D2 receptor subsensitivity, a feature of iron deficiency, is absent in haloperidol-treated, iron-deficient groups. On the contrary, these animals demonstrated biochemical and behavioral dopamine D2 receptor supersensitivity that is relatively greater than that observed with control, haloperidol-treated animals. Haloperidol (5 mg/kg daily for 21 days) as well as chlorpromazine (10 mg/kg daily for 21 days) caused a significant reduction (20-25%) in liver nonheme iron stores as compared with values in control rats. However, in iron-deficient rats, in which liver iron stores were almost totally depleted, haloperidol had no effect. The ability of chronic haloperidol treatment to prevent the reduction of dopamine D2 receptor number during iron deficiency may be associated with alteration of body iron status. Thus, less iron may result in an increase in free haloperidol available to the dopamine D2 receptor.
Arthroscopic Anterior Cruciate Ligament Reconstruction Using Fresh‐Frozen Bone Plug–Free Allogeneic Tendons: 10‐Year Follow‐up (2007)

Level IV, therapeutic case series.
Wafer-Level Vacuum-Packaged Flexible and Bendable Micro Accelerometer (2018)

This paper presents a wafer-level vacuum-packaged z-axis capacitive micro accelerometer fabricated on a flexible polyimide substrate and encapsulated by another polyimide superstrate enabling the flexibility, bendability, and portability of both the device and the package. The novel low-cost and low-temperature encapsulation procedure requires a fewer fabrication steps than the processes, where a thin epitaxial Si layer or a full Si wafer with cavity is used as a superstrate. It also provides a better pliability. The fabricated micro accelerometers demonstrated excellent integrity when bowed down to 2-cm radius of curvature with the sensitivity varying between 139 and 174 fF/g, depending on the design, under the application of ±4 g of acceleration. The resonant frequencies varied from 800 Hz for the largest device to 1050 Hz for the smallest device. The results reported here represent the best performing, waferlevel-packaged flexible micro accelerometers to date.
Dendritic Cells from Lupus-Prone Mice Are Defective in Repressing Immunoglobulin Secretion (2007)

Autoimmunity results from a breakdown in tolerance mechanisms that regulate autoreactive lymphocytes. We recently showed that during innate immune responses, secretion of IL-6 by dendritic cells (DCs) maintained autoreactive B cells in an unresponsive state. In this study, we describe that TLR4-activated DCs from lupus-prone mice are defective in repressing autoantibody secretion, coincident with diminished IL-6 secretion. Reduced secretion of IL-6 by MRL/lpr DCs reflected diminished synthesis and failure to sustain IL-6 mRNA production. This occurred coincident with lack of NF-kappaB and AP-1 DNA binding and failure to sustain IkappaBalpha phosphorylation. Analysis of individual mice showed that some animals partially repressed Ig secretion despite reduced levels of IL-6. This suggests that in addition to IL-6, DCs secrete other soluble factor(s) that regulate autoreactive B cells. Collectively, the data show that MRL/lpr mice are defective in DC/IL-6-mediated tolerance, but that some individuals maintain the ability to repress autoantibody secretion by an alternative mechanism.
Dependence of the two-photon photoluminescence yield of gold nanostructures on the laser pulse duration (2009)

Two-photon photoluminescence (TPPL) from gold nanostructures is becoming one of the most relevant tools for plasmon-assisted biological imaging and photothermal therapy as well as for the investigation of plasmonic devices. Here we study the yield of TPPL as a function of the temporal width $\ensuremath{\delta}$ of the excitation laser pulses for a fixed average power. In the $\ensuremath{\delta}&gt;1\text{ }\text{ps}$ regime, the TPPL yield decreases as $\ensuremath{\delta}$ is increased, while for shorter pulse widths it becomes independent of $\ensuremath{\delta}$ and, consequently, of the laser-pulse peak power. This peculiar dynamics is understood and modeled by considering that two-photon absorption in Au is a two-step process governed by the lifetime of the metastable state populated by the first photon absorption.
ChemInform Abstract: Ionic Liquids in Separations (2008)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Are we living in the end of the blockbuster drug era? (2010)

For the last two decades, we have seen remarkable growth in the pharmaceutical industry. This growth has mainly been due to the approximately 100 new blockbuster drugs, such as Lipitor® (atorvastatin) and Plavix® (clopidogrel). More than half of the revenue of major pharmaceutical companies and above one-third of the total pharmaceutical revenues came from the sales of these blockbuster drugs. Questions concerning the fate of these blockbuster drugs are beginning to surface as they are approaching their patent expiration dates, and as they are expected to face significant competition from generic versions. Branded drugs with more than USD 120 billion in sales (as of 2008) are expected to lose their patent protection in the next 3 to 4 years, while the less expensive generic versions are ready to enter the market. It is plausible that a major paradigm shift in our thinking is needed to stay innovative, competitive and economically feasible in this new era of drug development. A new wave of innovations is expected to boost the blockbuster regime. Herein, we discuss the different threats facing the branded monopoly, as well as some of the hopeful expectations for the blockbuster drug.
Recent Advances in the Chemistry of 1,3-Diketones: Structural Modifications and Synthetic Applications (2003)

Major aspects of the synthetic utility of 1,3-diketones are reviewed with special emphasis being placed on the regioselectivity of the transformations. The unsymmetrical 1,3-diketone moiety may contain up to five nucleophilic and two electrophilic centers that may only slightly differ in reactivity; therefore, it seems almost impossible to carry out chemical transformations with substrate selectively at only one specific center. However, in many cases it is possible, and in the present review answers to this question as well as many other useful synthetic applications of 1,3-diketones for the construction of carbocycles and heterocycles, and their modern implication in enantioselective, combinatorial, solid phase, and multistep organic syntheses are summarized.
Using Polypyrrole Coating to Improve Cycling Stability of NaTi<sub>2</sub>(PO<sub>4</sub>)<sub>3</sub>as an Aqueous Na-Ion Anode (2015)

Aqueous alkali - ion batteries offer an economical method for large-scale energy storage demanded by current sources of renewable energy. Although NASICON-type NaTi2(PO4)3 is an attractive anode material with high capacity and a low redox potential allowing for high voltage cells, it suffers from considerable capacity fade when cycled slowly and deeply. In this work polypyrrole has been introduced as a coating for NaTi2(PO4)3 through a high-energy ballmilling process. When an excessive coating was applied, no redox reactions from the NaTi2(PO4)3 were visible due to the poor Na+ diffusion through the polypyrrole. However, the as-coated composites containing 5 wt% polypyrrole showed much better capacity retention compared to the uncoated material, retaining 57% of the initial discharge capacity after 50 cycles compared to the uncoated material, which retained only 10% of the initial discharge capacity. It is concluded that coating NaTi2(PO4)3 with conducting polymers can be an effective strategy for promoting battery lifetime.
Frequency-Domain Spectroscopic Study of the PS I−CP43‘ Supercomplex from the Cyanobacterium <i>Synechocystis</i> PCC 6803 Grown under Iron Stress Conditions (2006)

Absorption, fluorescence excitation, emission, and hole-burning (HB) spectra were measured at liquid helium temperatures for the PS I-CP43' supercomplexes of Synechocystis PCC 6803 grown under iron stress conditions and for respective trimeric PS I cores. Results are compared with those of room temperature, time-domain experiments (Biochemistry 2003, 42, 3893) as well as with the low-temperature steady-state experiments on PS I-CP43' supercomplexes of Synechococcus PCC 7942 (Biochim. Biophys. Acta 2002, 1556, 265). In contrast to the CP43' of Synechococcus PCC 7942, CP43' of Synechocystis PCC 6803 possesses two low-energy states analogous to the quasidegenerate states A and B of CP43 of photosystem II (J. Phys. Chem. B 2000, 104, 11805). Energy transfer between the CP43' and the PS I core occurs, to a significant degree, through the state A, characterized with a broader site distribution function (SDF). It is demonstrated that the low temperature (T = 5 K) excitation energy transfer (EET) time between the state A of CP43' (IsiA) and the PS I core in PS I-CP43' supercomplexes from Synechocystis PCC 6803 is about 60 ps, which is significantly slower than the EET observed at room temperature. Our results are consistent with fast (< or =10 ps) energy transfer from state B to state A in CP43'. Energy absorbed by the CP43' manifold has, on average, a greater chance of being transferred to the reaction center (RC) and utilized for charge separation than energy absorbed by the PS I core antenna. This indicates that energy is likely transferred from the CP43' to the RC along a well-defined path and that the "red antenna states" of the PS I core are localized far away from that path, most likely on the B7-A32 and B37-B38 dimers in the vicinity of the PS I trimerization domain (near PsaL subunit). We argue that the A38-A39 dimer does not contribute to the red antenna region.
Spectroscopic Evidence for Aminomethylene (H−C−NH<sub>2</sub>)—The Simplest Amino Carbene (2018)

Although N-heterocyclic carbenes have been well-studied, the simplest aminocarbene, aminomethylene H-C̈-NH<sub>2</sub> , has not been spectroscopically identified to date. Herein we report the gas-phase preparation of aminomethylene by high-vacuum flash pyrolysis of cyclopropylamine and subsequent trapping of the pyrolysate in an inert argon matrix at 12 K. Aminomethylene was characterized by matching matrix IR and UV/Vis spectroscopic data with ab initio coupled cluster computations. After UV irradiation of the matrix aminomethylene rearranges to its isomer methanimine (formaldimine) H<sub>2</sub> C=NH. Based on our experimental results and computations aminomethylene has a singlet ground state with a reaction barrier of almost 46 kcal mol<sup>-1</sup> to methanimine so that H-tunneling is excluded.
Narrow-band amplified photoluminescence of amorphous silicon quantum dots via the coupling between localized surface plasmon and Fabry-Pérot cavity modes (2016)

We experimentally investigate the multifold intensity enhancement and spectral narrowing of photoluminescence (PL) from amorphous silicon quantum dots (a-Si QDs) embedded in a silicon-rich SiOx film of the Ag/SiOx:a-Si QDs/Au plasmonic nanocavity, through the resonance coupling between the localized surface plasmon (LSP) mode and the Fabry-Pérot (FP) cavity mode, by tuning a one-dimensional (1-D) Ag grating on the top. The LSP resonance can be precisely tuned by adjusting the Ag line widths of the 1-D Ag grating. It is found that the LSP mode strongly couples with the FP cavity mode, resulting in a narrower emission line width and a larger PL enhancement. An optimized Ag grating structure is found to exhibit a narrow emission line width of 15 nm and 2.77-fold enhancement in the PL peak intensity, as compared to an SiOx:a-Si QDs/Au structure without 1-D Ag grating, due to the strong resonance coupling between the two modes.
Manglicolous fungi from India (1992)

This paper deals with nine Ascomycetous fungi viz. Rhizophila marina Hyde et Jones, Trematosphaeria striatispora Hyde, Lineolata rhizophorae (Kohlm. et. Kohlm.) Kohlm. et. Volkm.-Kohlm., Caryosporella rhizophorae Kohlm., Passeriniella savoryellopsis Hyde et. Mouzouras, Hypoxylon oceanicum Scott Schatz. Belizeana tuberculata Kohlm. et. Volkm.-Kohlm., Swampomyces armeniacus Kohlm. et. Volkm.-Kohlm. and Hydronectria tehys Kohlm. et. Kohlm. var. glabra Kohlm. recorded for the first time from submerged parts of mangroves in India
Precision synthesis and atomistic analysis of deep blue cubic quantum dots made via self-organization (2022)

As a crystal approaches a few nm in size, atoms become nonequivalent, bonds vibrate, and quantum effects emerge. To study quantum dots (QDs) with structural control common in molecular science, we need atomic precision synthesis and analysis. We describe here the synthesis of QDs of lead bromide perovskite via self-organization of a lead malate chelate complex and PbBr3– under ambient conditions. Millisecond and angstrom resolution electron microscopic analysis revealed the structure and the dynamic behavior of individual QDs—structurally uniform cubes made of 64 lead atoms, where eight malate molecules are located on the eight corners of the cubes, and oleylamonium cations lipophilize and stabilize the edges and faces. Lacking translational symmetry, the cube is to be viewed as a molecule rather than a nanocrystal. The QD exhibits quantitative photoluminescence and stable electroluminescence at 460 nm with a narrow half-maximum linewidth of 15 nm, reflecting minimum structural defects. This controlled synthesis and precise analysis demonstrate the potential of cinematic chemistry for the characterization of nanomaterials beyond the conventional limit.
Kinetics of Dithionite-Dependent Reduction of Cytochrome P450 3A4:  Heterogeneity of the Enzyme Caused by Its Oligomerization (2005)

To explore the basis of apparent conformational heterogeneity of cytochrome P450 3A4 (CYP3A4), the kinetics of dithionite-dependent reduction was studied in solution, in proteoliposomes, and in Nanodiscs. In CYP3A4 oligomers in solution the kinetics obeys a three-exponential equation with similar amplitudes of each of the phases. Addition of substrate (bromocriptine) displaces the phase distribution toward the slow phase at the expense of the fast one, while the middle phase remains unaffected. The fraction reduced in the fast phase, either with or without substrate, is represented by the low-spin heme protein only, while the slow-reducible fraction is enriched in the high-spin CYP3A4. Upon monomerization by 0.15% Emulgen-913, or by incorporation into Nanodiscs or into large proteoliposomes with a high lipid-to-protein (L/P) ratio (726:1 mol/mol), the kinetics observed in the absence of substrate becomes very rapid and virtually monoexponential. In Nanodiscs and in lipid-rich liposomes bromocriptine decreases the rate of reduction via appearance of the second (slow) phase, the amplitude of which reaches 100% at saturating bromocriptine. In contrast, in P450-rich liposomes (L/P = 112 mol/mol), where the surface molar density of the enzyme is comparable to that observed in liver microsomes, CYP3A4 behaves similarly to that observed in solution. These results suggest that in CYP3A4 oligomers in solution and in the membrane the enzyme is distributed between two persistent conformers with different accessibility of the heme for the reductant (SO*-(2) anion monomer). One of the apparent conformers exists in a substrate-dependent equilibrium between two states with different rate constants of reduction by dithionite, while the second conformer shows no response to substrate binding.
Player zur Wiedergabe von erweiterten Videos - Bewertung durch Guidelines (2011)

Interaktive, nichtlineare und mit Zusatzinformationen versehene Videos bieten dem Betrachter weiterführende Informationen und erweiterte Steuerelemente zur Navigation im Video. Dies stellt umfassendere Anforderungen an einen Player als es bei herkömmlichen Videos der Fall ist. Diese Arbeit wertet drei Player an 50 Guidelines mit zugehörigem Bewertungsschema zur Umsetzung und Gestaltung aus. Diese Guidelines werden in die Bereiche “Design”, “Technik”, “Navigation”, “Suche” und “Benutzerfeedback und Fehlermeldungen” unterteilt. Im Anschluss erfolgt eine kritische Betrachtung des SIVA Players im Hinblick auf Verbesserungen.
Fluid Resuscitation Increases Inflammatory Gene Transcription After Traumatic Injury (2006)

Fluid resuscitation after solid organ injury and uncontrolled hemorrhage results in greater proinflammatory gene transcription than no resuscitation. LR and HEX resuscitation have equivalent effects on indices of inflammation in the lungs.
The Influence of B Cell Depletion Therapy on Naturally Acquired Immunity to Streptococcus pneumoniae (2021)

The anti-CD20 antibody Rituximab to deplete CD20+ B cells is an effective treatment for rheumatoid arthritis and B cell malignancies, but is associated with an increased incidence of respiratory infections. Using mouse models we have investigated the consequences of B cell depletion on natural and acquired humoral immunity to <i>Streptococcus pneumoniae</i>. B cell depletion of naïve C57Bl/6 mice reduced natural IgM recognition of <i>S. pneumoniae</i>, but did not increase susceptibility to <i>S. pneumoniae</i> pneumonia. ELISA and flow cytometry assays demonstrated significantly reduced IgG and IgM recognition of <i>S. pneumoniae</i> in sera from mice treated with B cell depletion prior to <i>S. pneumoniae</i> nasopharyngeal colonization compared to untreated mice. Colonization induced antibody responses to protein rather than capsular antigen, and when measured using a protein array B cell depletion prior to colonization reduced serum levels of IgG to several protein antigens. However, B cell depleted <i>S. pneumoniae</i> colonized mice were still partially protected against both lung infection and septicemia when challenged with <i>S. pneumoniae</i> after reconstitution of their B cells. These data indicate that although B cell depletion markedly impairs antibody recognition of <i>S. pneumoniae</i> in colonized mice, some protective immunity is maintained, perhaps mediated by cellular immunity.