gebhart/patrepeval huggingface dataset:
Network-Based Data Flow Processing System with Variable Data Granularity for Inter-module Communication (2009)

Integration of many functions in mobile devices often results in the insufficiency of computing resources and security problems. We utilize multiple computing modules distributed in the environment as external resources, and call this processor network system ¿UMP (Ubiquitous Multi Processor) system.¿ In our previous research, the basic architecture of a UMP system and its communication theory were verified. This paper evaluates the correlation between data granularity and system performance for applications with variable data granularity and verifies the usefulness of these parameters in dynamic scheduling necessary to construct intelligent systems. A JPEG encoding application was evaluated on the UMP system with six sub-functional modules. Optimization of data granularity shows 180% improvement of system performance. The experimental result shows that data granularity of inter-PE communication could be an important parameter in optimizing the system architecture and dynamic scheduling. Moreover, the result shows the possibility of further performance improvement through optimization of data granularity by focusing on individual modules.
Relating the Organization of the Molecular Tilt Azimuth to Lateral-Force Images in Monolayers Transferred to Solid Substrates (1998)

The molecular tilt azimuth in domains of a condensed phase in monolayers of glycerol esters at the air/water interface exhibits a regular star texture. Lateral-force images of these monolayers that have been transferred to a silicon substrate show that the tilt organization survives. Regular patterns are also found in images of monolayers on mica, but the organization differs from that observed at the air/water interface.
The miniSLR: A low-budget, high-performance satellite laser ranging ground station (2023)

Satellite Laser Ranging (SLR) is an established technique providing very accurate position measurements of satellites in Earth orbit. However, despite decades of development, it remains a complex and expensive technology, which impedes its further growth to new applications and users. The miniSLR implements a complete SLR system within a small, transportable enclosure. Through this design, costs of ownership can be reduced significantly, and the process of establishing a new SLR site is greatly simplified. A number of novel technical solutions have been implemented to achieve a good laser ranging performance despite the small size and simplified design. Data from the initial six months of test operation has been used to generate a first estimation of the system performance. The data includes measurements to many of the important SLR satellites, such as Lageos, Etalon and most of the geodetic and Earth observation missions in LEO. It is shown that the miniSLR achieves sub-centimetre accuracy, comparable with conventional SLR systems. The miniSLR is an engineering station in the International Laser Ranging Service (ILRS), and supplies data to the community. Continuous efforts are undertaken to further improve the system operation and stability.
cDNA clones from autocrine thymic lymphoma cells encode two mitogenic proteins, a serine protease and a truncated T-cell receptor beta-chain. (1988)

Cell lines derived from primary X-ray induced T cell lymphomas (PXTL) of C57BL/6 mice secrete into the medium factor(s) required for their growth. These autocrine factor(s) are distinct from previously described growth factors. cDNA cloning experiments were performed in an attempt to identify these autocrine factor(s). cDNA clones were selected by mRNA size, differential expression, and mitogenic activity of their translation products (Xenopus expression system) on PXTL cells. Two different cDNA clones yielded distinct mitogenic proteins. One clone encodes an altered form of the T cell receptor beta-chain which is truncated at the N-terminus to amino acid 49 of the constant region beta 2. The second clone encodes a serine protease which is identical to factor H or granzyme A from cytotoxic T cells. The 5' portion of the cDNA encoding the serine protease derived from PXTL cells differs from that derived from cytotoxic T cells. This difference results in distinct signal peptides. Unlike cytotoxic T cells, PXTL cells do not store the serine protease intracellularly but secrete it.
Proximity to livestock farms and exposure to livestock-related particulate matter are associated with lower probability of medication dispensing for obstructive airway diseases (2020)

The results show that the probability of dispensing medication for asthma or COPD is inversely associated with proximity to livestock farms and modelled exposure to livestock-related PM<sub>10</sub> in multiple regions within the Netherlands. This finding implies a notable prevented risk: under the assumption of absence of livestock farms in the Netherlands, an estimated 2%-5% more persons (an increase in tens of thousands) in rural areas would receive asthma or COPD medication.
Biodegradable Composites Developed from PBAT/PLA Binary Blends and Silk Powder: Compatibilization and Performance Evaluation (2018)

Silk fibroin powder and biodegradable polybutylene adipate terephthalate (PBAT)/poly lactide (PLA) blends were melt-mixed together to fabricate natural and synthetic polymers as possible new sources of biomaterials. Morphological observations conducted through scanning electron microscopy indicated poor dispersion of the silk powder agglomerates, which resulted from strong hydrogen interactions between silk powder chains in the PBAT/PLA matrix. Although the silk powder agglomerates decreased the mechanical properties, as silk powder fractions increased, the ternary blend with 10 wt % silk powder still displayed high impact strength of 108 J/m and tensile modulus of 1.2 GPa. On the basis of mechanical analysis, this blend offered potential applications in fields which required high impact strength. Blends which contained Joncryl experienced a decrease in storage modulus. Furthermore, rheological studies confirmed that the viscosity of the PBAT/PLA/Silk powder blends decreased, which indicated possible weakening of hydrogen bonds between the silk chains, caused by the reaction between the epoxy groups of Joncryl. This reaction provides a possible method to improve the processability of this natural polymer and to improve its distribution in polymer blends.
Protein Sieving with Capillary Nanogel Electrophoresis (2020)

Protein sieving, which is a fundamental tool in the biotechnology field, can be automated using capillary gel electrophoresis. The high-viscosity and biocompatible linear gels required for capillary sieving must be replaced for each run using high pressures. Thermally responsive gels are easier to renew in the capillary as they can be repetitively switched between low- and high-viscosity solutions. A thermally responsive sieving gel was recently demonstrated to separate DNA, which is a larger biomolecule than proteins. This material required no synthesis as it was self-assembled from common phospholipids. Nanogels composed of dimyristoyl-<i>sn</i>-glycero-2-phosphocholine and 1,2-dihexanoyl-<i>sn</i>-glycero-3-phosphocholine exhibit thermally reversible viscosity within a 10 °C temperature change, forming a sieving matrix above 24 °C. Additionally, these nanogels are nondenaturing and have been demonstrated to preserve the activity of enzymes. In this report, a phospholipid nanogel is used for the first time for capillary gel electrophoresis separations of proteins. The mobilities in buffer and nanogel demonstrated that 20-30% nanogel supports sieving of proteins ranging from 20 to 80 kDa. Capillary separations based on sieving rather than electrophoresis had similar precision in both area and migration time as well as similar separation efficiencies. However, the migration time increased with gel concentration. The nanogel was used for the analysis of proteins in human serum. Proteins in the sample were more effectively resolved and quantified with capillary sieving compared to free-solution capillary electrophoresis. This allowed for accurate quantification.
Computation of the nonlinear Nyquist robust stability margin for structured uncertainties (2004)

The critical direction theory for analyzing the robustness of uncertain feedback systems is extended to include nonlinear elements in the closed loop, making the approach applicable to a wider class of systems. A redefinition of the critical perturbation radius is introduced, preserving key properties of the original theory. Necessary and sufficient conditions for robust stability are developed, and the case of real affine parametric uncertainties is treated in detail. An example is presented to illustrate the theory.
The Increased Costs of Donation After Cardiac Death Liver Transplantation (2010)

In Brief Objective: To determine the effect of donation after cardiac death (DCD) livers on post-transplantation costs. Background: DCD livers are increasingly being used to expand the donor pool despite higher complication rates. Although complications after liver transplantation have profound financial implications, the effect of DCD livers on post-transplantation costs has not been studied. Methods: We estimated direct medical care costs based on inpatient and outpatient hospital costs for 28 DCD and 198 donation after brain death (DBD) liver recipients. Organ acquisition and physician costs were excluded. Results: Donor and recipient demographics were comparable for DCD and DBD transplants. One-year, post-transplantation costs were higher for DCD recipients (124.9% of DBD costs, P = 0.04). DCD costs remained higher (125.2% of DBD costs, P = 0.009) after adjusting for recipient characteristics. Furthermore, DCD post-transplantation costs were 30% higher than DBD costs after adjusting for pre-transplantation costs (P = 0.02). Biliary complications (DCD 58% vs. DBD 21%; P < 0.001) and, specifically, ischemic cholangiopathy (DCD 44% vs. DBD 1.6%; P < 0.001) occurred more frequently after DCD transplantation. Moreover, DCD recipients underwent retransplantation more often (DCD 21% vs. DBD 7.1%, P = 0.02). One-year costs were increased for recipients with ischemic cholangiopathy or retransplantation by 53% (P = 0.01) and 107% (P < 0.001), respectively. However, DCD costs continued to be higher when retransplanted patients were excluded (120% of DBD costs, P = 0.02). Conclusions: Higher rates of graft failure and biliary complications translate into markedly increased direct medical care costs for DCD recipients. These important financial implications should be considered in decisions regarding the use of DCD livers. We present a comparison of direct medical care costs based on inpatient and outpatient hospital costs between donation after cardiac death and donation after brain death liver transplant recipients. Costs from date of transplantation through 1 year of follow-up were evaluated to identify differences according to graft type and the effect of post-transplant complications.
Pathophysiology and assessment of neuropathic pain in Fabry disease (2002)

Severe neuropathic pain and hypohidrosis are important symptoms of Fabry disease, particularly in the first three decades of life. The pain is associated with a length-dependent small-fibre neuropathy that also causes a selective deficiency of cold perception. Cold exposure often accentuates the pain and worsens thermal perception. The hypohidrosis leads to poor exercise and heat tolerance. The mechanisms by which α-galactosidase A deficiency causes these physiological abnormalities are poorly understood. The stored glycolipid (globotriaosylceramide) may interfere with the function of cellular membrane proteins, such as ion channels, or may lead to cytotoxicity. The characteristic neuropathic pain can be symptomatically treated with various types of anticonvulsant drugs, such as carbamazepine. Improvement in neuropathic pain as a primary outcome measure has been useful in demonstrating that enzyme replacement therapy is effective in improving pain-related quality of life in Fabry disease. Conclusions: The dysfunction of the peripheral nervous system is easily assessable and more readily reversible with specific therapy than the destructive processes that occur in organs such as the kidney. In future, therefore, it is likely that neuropathic pain, quantitative sensory testing and hypohidrosis will serve as clinical outcome measures for studies of specific and effective therapies for Fabry disease.
ChemInform Abstract: Syntheses of Aminoalcohol‐Derived Macrocycles Leading to a Small‐Molecule Binder to and Inhibitors of Sonic Hedgehog. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 2522: Molecular and cellular mechanisms underlying the therapeutic efficacy of the combination of JAK inhibitor, ruxolitinib, PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011, in a preclinical model of myeloproliferative neoplasia (2015)

Abstract The JAK-STAT pathway is an important signaling pathway downstream of multiple cytokine and growth factor receptors. The genetic aberration of JAK2V617F and the associated activation of STAT in myeloproliferative neoplasia (MPN) is one example of the involvement of this pathway in human cancer. We have previously shown the combination benefits of combining ruxolitinib (Jak1,2 inhibitor), with LGH447 (PIM inhibitor) and LEE011 (CDK4/6 inhibitor) in a Ba/F3-JAK2V617F-driven MPN model. Here, we set to explore the molecular and cellular mechanisms underlying this combination benefit in the JAK2V617F UKE-1 model of MPN. The triple combination of ruxolitinib, LGH447 and LEE011 resulted in sustained tumor regression in the UKE-1 model. Ruxolitinib, LGH447 and LEE011 inhibited pSTAT5, pBAD and pRb respectively. The monotherapies and the combination of ruxolitinib + LGH447 did not affect G1-S cycle. In contrast, the combination of ruxolitinib+LEE011, LGH447+LEE011 and the triple combination resulted in significant inhibition of G1-S progression. Consequently, after 72 hours of treatment, the percentage of cells in S phase decreased from 67% under DMSO to 15.8% under ruxolitinib+LEE011, and to 1.6% under the triple combination. Furthermore, monotherapies of LGH447 or LEE011 did not affect cell viability. Ruxolitinib monotherapy and ruxolitinib+LGH447 combination reduced viable cell% by 47% and 86%, respectively. The triple combination reduced it by 91%. Our data suggest that the triple combination efficacy is the result of both cell killing and cell cycle blockade. The inhibition of JAK-PIM pathway significantly reduced cell viability. And the inclusion of CDK4/6 inhibition by LEE011 lead to more potent cell killing and cell growth arrest. Taken together, the triple combination achieves sustained tumor regression in preclinical models of MPN. Citation Format: Maria Pinzon-Ortiz, Tyler Longmire, Xianhui Rong, Giordano Caponigro, Gary Vanasse, Benjamin H. Lee, Z. Alexander Cao. Molecular and cellular mechanisms underlying the therapeutic efficacy of the combination of JAK inhibitor, ruxolitinib, PIM inhibitor, LGH447, and CDK4/6 inhibitor, LEE011, in a preclinical model of myeloproliferative neoplasia. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 2522. doi:10.1158/1538-7445.AM2015-2522
Time-resolved dual root-microbe transcriptomics reveals early induced <i>Nicotiana benthamiana</i> genes and conserved infection-promoting <i>Phytophthora palmivora</i> effectors (2017)

Abstract Background Plant-pathogenic oomycetes are responsible for economically important losses on crops worldwide. Phytophthora palmivora , a broad-host-range tropical relative of the potato late blight pathogen, causes rotting diseases in many important tropical crops including papaya, cocoa, oil palm, black pepper, rubber, coconut, durian, mango, cassava and citrus. Transcriptomics have helped to identify repertoires of host-translocated microbial effector proteins which counteract defenses and reprogram the host in support of infection. As such, these studies have helped understanding of how pathogens cause diseases. Despite the importance of P. palmivora diseases, genetic resources to allow for disease resistance breeding and identification of microbial effectors are scarce. Results We employed the model plant N. benthamiana to study the P. palmivora root infections at the cellular and molecular level. Time-resolved dual transcriptomics revealed different pathogen and host transcriptome dynamics. De novo assembly of P. palmivora transcriptome and semi-automated prediction and annotation of the secretome enabled robust identification of conserved infection-promoting effectors. We show that one of them, REX3, suppresses plant secretion processes. In a survey for early transcriptionally activated plant genes we identified a N. benthamiana gene specifically induced at infected root tips that encodes a peptide with danger-associated molecular features. Conclusions These results constitute a major advance in our understanding of P. palmivora diseases and establish extensive resources for P. palmivora pathogenomics, effector-aided resistance breeding and the generation of induced resistance to Phytophthora root infections. Furthermore, our approach to find infection relevant secreted genes is transferable to other pathogen-host interactions and not restricted to plants.
Impact of Fractures on CO2 Storage Monitoring - An Integrated Approach (2008)

The monitoring of CO2 storage in fractured reservoirs (depleted hydrocarbon field or brine aquifers) requires the study of the impact of fracturation and fluid substitution on seismic data. Seismic data can provide information about the additional compliance due to the fractures and to the fluids through the analysis of seismic azimuthal anisotropy and the introduction of a rock physics model providing a realistic description of fractured media (where porosity, multiphasic fluid phases, inherent seismic anisotropy, the presence of multiple sets of fractures and their connection with porosity can be considered). Seismic methods by themselves cannot fully describe fracturation and must be associated with other methods through an integrated approach. First, borehole and outcrop geological information can give the upper limit of the fracture density expected at depth in the same formation. Second, rock mechanics helps understanding the fracturation state at depth.
Anode Catalysts for the Direct Dimethyl Ether Fuel Cell (2011)

For the last decade, dimethyl ether (DME) has been considered a promising alternative fuel for direct fuel cells because of several advantages over methanol. In this work, PtRu catalysts with a wide range of Pt-to-Ru ratios were screened for the direct DME fuel cell(DDMEFC) performance for the first time. Overall, Pt50Ru50 performs best in the high and middle voltage ranges, whereas Pt80Ru20 performs best at low voltages. A maximum power density of 0.10 W/cm2 is achieved at a current density of 0.37 A/cm2. In spite of using gaseous DME feed, the measured performance exceeds the best previously published results. The anode activity and fuel crossover of a DDMEFC were investigated in this work and compared to those of a DMFC. The adsorption and electrooxidation of DME on Pt black catalyst were also studied in halfcell electrochemical measurements.
Integrative phosphoproteomics defines two biologically distinct groups of KMT2A rearranged acute myeloid leukaemia with different drug response phenotypes (2022)

ABSTRACT Acute myeloid leukaemia (AML) patients harbouring certain chromosome abnormalities have particularly adverse prognosis. For these patients, targeted therapies have not yet made a significant clinical impact. To understand the molecular landscape of poor prognosis AML we profiled 74 patients from two different centres (in UK and Finland) at the proteomic, phosphoproteomic and drug response phenotypic levels. These data were complemented with transcriptomics analysis for 39 cases. Data integration highlighted a phosphoproteomics signature that define two biologically distinct groups of KMT2A rearranged leukaemia, which we term MLLGA and MLLGB. MLLGA presented increased DOT1L phosphorylation, HOXA gene expression, CDK1 activity and phosphorylation of proteins involved in RNA metabolism, replication and DNA damage when compared to MLLGB and no KMT2A rearranged samples. MLLGA was particularly sensitive to 15 compounds including genotoxic drugs and inhibitors of mitotic kinases and inosine-5-monosphosphate dehydrogenase (IMPDH) relative to other cases. Intermediate-risk KMT2A-MLLT3 cases were mainly represented in a third group closer to MLLGA than to MLLGB. The expression of IMPDH2 and multiple nucleolar proteins was higher in MLLGA and correlated with the response to IMPDH inhibition in KMT2A rearranged leukaemia, suggesting a role of the nucleolar activity in sensitivity to treatment. In summary, our multilayer molecular profiling of AML with poor prognosis and KMT2A-MLLT3 karyotypes identified a phosphoproteomics signature that defines two biologically and phenotypically distinct groups of KMT2A rearranged leukaemia. These data provide a rationale for the potential development of specific therapies for AML patients characterised by the MLLGA phosphoproteomics signature identified in this study.
Proteins That Nature Never Made (2009)

The 24th annual Ashton Cary Lecture was presented on April 1, 2009, from 4-5 pm in room G011 of the Molecular Science and Engineering Building on the Georgia Tech Campus.
Parabolic reflectarray antenna to generate multiple beams for geostationary high throughput satellites in Ka-band (2022)

Abstract This contribution describes the design and simulations of a multibeam 1.8 m parabolic reflectarray antenna for geostationary high throughput satellites (HTS) in Ka-band. The parabolic reflectarray generates two orthogonal circularly polarized beams per feed simultaneously at 19.7 and 29.5 GHz, by the variable rotation technique. The antenna is made of 62 654 reflectarray cells, which include two types of printed elements independently rotated and adjusted. The elements have been optimized one by one to ensure the required phase-shift at each frequency. A novel design approach has made it possible to promptly obtain an initial layout of every element with a very low computational cost. The simulated radiation patterns show that the parabolic reflectarray, illuminated by 27 dual-circularly polarized feeds, can generate 54 spot-beams in two orthogonal polarizations, with a beam spacing of 0.56° between adjacent beams. The design and simulation tools have been validated by a parabolic reflectarray scaled in a factor of 0.5, which has been manufactured and tested. The proposed reflectarray would allow to generate a complete multi-spot coverage from a geostationary HTS with only two parabolic reflectarrays, instead of four reflector antennas, also reducing the number of feeds by half, since every feed generates two beams.