MP67-15 TARGETED MAGNETIC RESONANCE IMAGING/ULTRASOUND FUSION BIOPSY IS A SIGNIFICANTLY BETTER PREDICTOR OF TOTAL PROSTATE CANCER TUMOR VOLUME THAN RANDOM 12-CORE BIOPSY (2014)

You have accessJournal of UrologyProstate Cancer: Detection & Screening IV1 Apr 2014MP67-15 TARGETED MAGNETIC RESONANCE IMAGING/ULTRASOUND FUSION BIOPSY IS A SIGNIFICANTLY BETTER PREDICTOR OF TOTAL PROSTATE CANCER TUMOR VOLUME THAN RANDOM 12-CORE BIOPSY Chinonyerem Okoro, Arvin George, Soroush Rais-Bahrami, Annerleim Walton-Diaz, M. Minhaj Siddiqui, Nabeel A. Shakir, Jason T. Rothwax, Dima Raskolnikov, Lambros Stamatakis, Daniel Su, Baris Turkbey, Peter L. Choyke, Bradford J. Wood, Maria Merino, and Peter A. Pinto Chinonyerem OkoroChinonyerem Okoro More articles by this author , Arvin GeorgeArvin George More articles by this author , Soroush Rais-BahramiSoroush Rais-Bahrami More articles by this author , Annerleim Walton-DiazAnnerleim Walton-Diaz More articles by this author , M. Minhaj SiddiquiM. Minhaj Siddiqui More articles by this author , Nabeel A. ShakirNabeel A. Shakir More articles by this author , Jason T. RothwaxJason T. Rothwax More articles by this author , Dima RaskolnikovDima Raskolnikov More articles by this author , Lambros StamatakisLambros Stamatakis More articles by this author , Daniel SuDaniel Su More articles by this author , Baris TurkbeyBaris Turkbey More articles by this author , Peter L. ChoykePeter L. Choyke More articles by this author , Bradford J. WoodBradford J. Wood More articles by this author , Maria MerinoMaria Merino More articles by this author , and Peter A. PintoPeter A. Pinto More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2014.02.2082AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Tumor quantification with percent core and/or core length involvement is used to infer burden of disease for patients with prostate cancer (PCa). However, controversy exists regarding tumor quantification in random 12−core biopsies due to discrepancies in lesion targeting and overall needle core lengths obtained. Targeted magnetic resonance imaging/ultrasound (MRI/US) fusion biopsy allows for more optimal lesion targeting and interpretation of this parameter. We aim to correlate highest percentage core involvement and corresponding tumor length for both targeted fusion and random 12−core biopsies with total tumor volume. METHODS Patients who underwent multiparametric MRI (MP−MRI) with targeted MRI/US fusion biopsy at our institution between 2007 and 2013 were reviewed. MRI tumor volumes were calculated in fusion biopsy positive lesions and correlated with the highest percentage core involvement and corresponding tumor length in centimeters, for both targeted fusion biopsy and 12−core biopsy. Bivariate analysis was used to determine the empirical relationship between these variables and the correlative R2 value. RESULTS 823 patients had MP−MRI with MRI/US fusion biopsy, of which 100 patients had MRI tumor volumes quantified. Mean age was 62 years and mean PSA was 5.5ng/ml. For highest percentage core involvement, targeted biopsy showed a positive correlation (R=0.54) whereas 12−core biopsy showed a poor correlation (R=0.004) with total tumor volume (p<0.0001, p=0.97 respectively). Similarly, for tumor length of the highest percentage core, targeted biopsy showed a positive correlation (R=0.56) whereas 12−core biopsy showed a poor correlation (R=0.06) with the total tumor volume (p<0.0001 and p=0.59 respectively). (Figure 1) CONCLUSIONS Highest percentage core involvement and tumor length on targeted MRI/US fusion biopsy positively correlate with total tumor volume. Targeted biopsy better predicts overall burden of disease and can aid in risk stratification of PCa patients. © 2014FiguresReferencesRelatedDetails Volume 191Issue 4SApril 2014Page: e755 Advertisement Copyright & Permissions© 2014MetricsAuthor Information Chinonyerem Okoro More articles by this author Arvin George More articles by this author Soroush Rais-Bahrami More articles by this author Annerleim Walton-Diaz More articles by this author M. Minhaj Siddiqui More articles by this author Nabeel A. Shakir More articles by this author Jason T. Rothwax More articles by this author Dima Raskolnikov More articles by this author Lambros Stamatakis More articles by this author Daniel Su More articles by this author Baris Turkbey More articles by this author Peter L. Choyke More articles by this author Bradford J. Wood More articles by this author Maria Merino More articles by this author Peter A. Pinto More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...