gebhart/patrepeval huggingface dataset:
A Linear Phase Condition for Volterra Filters (2007)

In linear finite-impulse-response filter design, it is desirable that the filter frequency response has linear phase (LP). In this brief, we investigate the LP concept for nonlinear Volterra filters. The LP condition of Volterra filters is defined in terms of its output spectrum in which the phase term introduced by the Volterra kernels is linear. It is shown that under certain symmetry conditions, the LP condition is satisfied by Volterra filters. Moreover, the LP condition for Volterra filters can be considered as an extension to the linear filter case.
ESWORD: Implementation of Wireless Jamming Attacks in a Real-World Emulated Network (2023)

Wireless jamming attacks have plagued wireless communication systems and will continue to do so going forward with technological advances. These attacks fall under the category of Electronic Warfare (EW), a continuously growing area in both attack and defense of the electromagnetic spectrum, with one subcategory being electronic attacks. Jamming attacks fall under this specific subcategory of EW as they comprise adversarial signals that attempt to disrupt, deny, degrade, destroy, or deceive legitimate signals in the electromagnetic spectrum. While jamming is not going away, recent research advances have started to get the upper hand against these attacks by leveraging new methods and techniques, such as machine learning. However, testing such jamming solutions on a wide and realistic scale is a daunting task due to strict regulations on spectrum emissions. In this paper, we introduce eSWORD, the first large-scale framework that allows users to safely conduct real-time and controlled jamming experiments with hardware-in-the-loop. This is done by integrating eSWORD into the Colosseum wireless network emulator that enables large-scale experiments with up to 50 software-defined radio nodes. We compare the performance of eSWORD with that of real-world jamming systems by using an over-the-air wireless testbed (ensuring safe measures were taken when conducting experiments). Our experimental results demonstrate that eSWORD follows similar patterns in throughput, signal-to-noise ratio, and link status to real-world jamming experiments, testifying to the high accuracy of the emulated eSWORD setup.
ChemInform Abstract: Rh(III)‐Catalyzed C—H Olefination of N‐Pentafluoroaryl Benzamides Using Air as The Sole Oxidant. (2015)

ChemInformVolume 46, Issue 27 Heterocyclic Compounds ChemInform Abstract: Rh(III)-Catalyzed C—H Olefination of N-Pentafluoroaryl Benzamides Using Air as The Sole Oxidant. Yi Lu, Yi Lu Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorHuai-Wei Wang, Huai-Wei Wang Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorJillian E. Spangler, Jillian E. Spangler Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorKai Chen, Kai Chen Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorPei-Pei Cui, Pei-Pei Cui Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorYue Zhao, Yue Zhao Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorWei-Yin Sun, Wei-Yin Sun Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorJin-Quan Yu, Jin-Quan Yu Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this author Yi Lu, Yi Lu Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorHuai-Wei Wang, Huai-Wei Wang Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorJillian E. Spangler, Jillian E. Spangler Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorKai Chen, Kai Chen Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorPei-Pei Cui, Pei-Pei Cui Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorYue Zhao, Yue Zhao Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorWei-Yin Sun, Wei-Yin Sun Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this authorJin-Quan Yu, Jin-Quan Yu Coord. Chem. Inst., Nanjing Univ., Nanjing 210093, Peop. Rep. ChinaSearch for more papers by this author First published: 18 June 2015 https://doi.org/10.1002/chin.201527152Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume46, Issue27July, 2015 RelatedInformation
Impaired Activated/Memory Regulatory T Cell Clonal Expansion Instigates Diabetes in NOD Mice (2021)

Regulatory T cell (Treg) insufficiency licenses the destruction of insulin-producing pancreatic b cells by auto-reactive effector T cells (Teffs), causing spontaneous autoimmune diabetes in non‑obese diabetic (NOD) mice. We investigated the contribution to diabetes of the TCR repertoires of naive regulatory T cells (nTregs), activated/memory Tregs (amTregs), and CD4&lt;sup&gt;+&lt;/sup&gt; Teffs from prediabetic NOD mice and normal C57BL/6 (B6) mice. NOD mice amTreg and Teff repertoire diversity was unexpectedly higher than that of B6 mice. This was due to the presence of highly expanded clonotypes in B6 amTregs and Teffs that were largely lost in their NOD counterparts. IL-2 administration to NOD mice restored such amTreg clonotype expansions and prevented diabetes development. In contrast, IL-2 administration only led to few or no clonotype expansions in nTregs and Teffs, respectively. Noteworthily, IL-2 expanded amTreg and nTreg clonotypes were markedly enriched in islet-antigen specific TCRs. Altogether, our results highlight the link between a reduced clonotype expansion within the activated Treg repertoire and the development of an autoimmune disease. They also indicate that the repertoire of amTregs is amenable to rejuvenation by IL-2.
Cell‐type‐ and tissue‐specific transcriptomes of the white spruce (<i>Picea glauca</i>) bark unmask fine‐scale spatial patterns of constitutive and induced conifer defense (2017)

Plant defenses often involve specialized cells and tissues. In conifers, specialized cells of the bark are important for defense against insects and pathogens. Using laser microdissection, we characterized the transcriptomes of cortical resin duct cells, phenolic cells and phloem of white spruce (Picea glauca) bark under constitutive and methyl jasmonate (MeJa)-induced conditions, and we compared these transcriptomes with the transcriptome of the bark tissue complex. Overall, ~3700 bark transcripts were differentially expressed in response to MeJa. Approximately 25% of transcripts were expressed in only one cell type, revealing cell specialization at the transcriptome level. MeJa caused cell-type-specific transcriptome responses and changed the overall patterns of cell-type-specific transcript accumulation. Comparison of transcriptomes of the conifer bark tissue complex and specialized cells resolved a masking effect inherent to transcriptome analysis of complex tissues, and showed the actual cell-type-specific transcriptome signatures. Characterization of cell-type-specific transcriptomes is critical to reveal the dynamic patterns of spatial and temporal display of constitutive and induced defense systems in a complex plant tissue or organ. This was demonstrated with the improved resolution of spatially restricted expression of sets of genes of secondary metabolism in the specialized cell types.
Rituximab prophylaxis prevents corticosteroid-requiring chronic GVHD after allogeneic peripheral blood stem cell transplantation: results of a phase 2 trial (2013)

Key Points Rituximab prevents steroid-requiring chronic graft-vs-host disease when given after peripheral blood stem cell transplantation. Overall survival is improved with rituximab after allogeneic peripheral blood stem cell transplantation when compared with a control cohort.
Efficient implementation of a real-time estimation system for thalamocortical hidden Parkinsonian properties (2017)

Real-time estimation of dynamical characteristics of thalamocortical cells, such as dynamics of ion channels and membrane potentials, is useful and essential in the study of the thalamus in Parkinsonian state. However, measuring the dynamical properties of ion channels is extremely challenging experimentally and even impossible in clinical applications. This paper presents and evaluates a real-time estimation system for thalamocortical hidden properties. For the sake of efficiency, we use a field programmable gate array for strictly hardware-based computation and algorithm optimization. In the proposed system, the FPGA-based unscented Kalman filter is implemented into a conductance-based TC neuron model. Since the complexity of TC neuron model restrains its hardware implementation in parallel structure, a cost efficient model is proposed to reduce the resource cost while retaining the relevant ionic dynamics. Experimental results demonstrate the real-time capability to estimate thalamocortical hidden properties with high precision under both normal and Parkinsonian states. While it is applied to estimate the hidden properties of the thalamus and explore the mechanism of the Parkinsonian state, the proposed method can be useful in the dynamic clamp technique of the electrophysiological experiments, the neural control engineering and brain-machine interface studies.
Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids (2020)

Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet currently, no vaccines or FDA-approved antiviral drugs are available to counter these pathogens. To understand HuNoV biology and the epithelial response to infection, we performed transcriptomic analyses, RT-qPCR, CRISPR-Cas9 modification of human intestinal enteroid (HIE) cultures, and functional studies with two virus strains (a pandemic GII.4 and a bile acid-dependent GII.3 strain). We identified a predominant type III interferon (IFN)-mediated innate response to HuNoV infection. Replication of both strains is sensitive to exogenous addition of IFNs, suggesting the potential of IFNs as therapeutics. To obtain insight into IFN pathway genes that play a role in the antiviral response to HuNoVs, we developed knockout (KO) HIE lines for IFN alpha and lambda receptors and the signaling molecules, <i>MAVS</i>, <i>STAT1</i>, and <i>STAT2</i> An unexpected differential response of enhanced replication and virus spread was observed for GII.3, but not the globally dominant GII.4 HuNoV in <i>STAT1-knockout</i> HIEs compared to parental HIEs. These results indicate cellular IFN responses restrict GII.3 but not GII.4 replication. The strain-specific sensitivities of innate responses against HuNoV replication provide one explanation for why GII.4 infections are more widespread and highlight strain specificity as an important factor in HuNoV biology. Genetically modified HIEs for innate immune genes are useful tools for studying immune responses to viral or microbial pathogens.
Design of the musculoskeletal trunk and realization of powerful motions using spines (2007)

We are developing the novel musculoskeletal humanoid that is able to do coordinated motion with arms, legs and especially trunk body. In this research, we designed and implemented the trunk consisting of redundant articulated spine joints which can hold up and drive the upper body and pelvis. Furthermore, we confirmed that this trunk body ability to do fullbody motion, by an experiment of spine rotation motions with the real humanoid developed.
RICE (2018)

Information Centric Networking has been proposed as a new network layer for the Internet, capable of encompassing the full range of networking facilities provided by the current IP architecture. In addition to the obvious content-fetching use cases which have been the subject of a large body of work, ICN has also shown promise as a substrate to effectively support remote computation, both pure functional programming (as exemplified by Named Function Networking) and more general remote invocation models such as RPC and web transactions. Providing a unified remote computation capability in ICN presents some unique challenges, among which are timer management, client authorization, and binding to state held by servers, while maintaining the advantages of ICN protocol designs like CCN and NDN. In this paper we present a unified approach to remote function invocation in ICN that exploits the attractive ICN properties of name-based routing, receiver-driven flow and congestion control, flow balance, and object-oriented security while presenting a natural programming model to the application developer.
Commentary (2013)

Dudley, Michael N. PharmD*; Ambrose, Paul G. PharmD†; Jones, Ronald N. MD‡ Author Information
Laser Scheimpflug Videography (1996)

Conventional Scheimpflug photography uses slits with a constant width of 80 microns. This parameter limits the resolution as sharp contours are imaged with a basic uncertainty. In order to reduce this basic uncertainty we developed an illumination slit with a width of 20 microns and less, using a green helium-neon laser (543 nm). With this slit, much sharper imaging of ocular contours can be achieved. Since this illumination is coupled to on-line videographic detection of the Scheimpflug image, any adjustment of the target is done under visual control at the monitor. Using this device, the slope of a densitogram of contrasted contours (for example the corneal surfaces) is steeper, which guarantees a more accurate detection of corneal thickness and curvature.
Raman spectroscopic study of bulk water supercooled to − 33 °C (1990)

We present Raman spectroscopic measurements in the OH stretch region of water (2900 to 3800 cm−1) for the temperature range 80 to −33 °C. This latter temperature represents the homogeneous limit of nucleation for our bulk samples. We find that the temperature dependence of both our intensity and depolarization ratio measurements are well described by a two-state model in which both states have frequency dependent depolarization ratios. We argue that the hydrogen bonded mode of the spectrum begins to develop a collective nature at both its low and high frequency ends. This collective nature can explain a breakdown in isosbestic behavior at low temperature. It is suggested that these collective modes may be due to in- and out-of-phase motions of OH oscillators. Their intensity approaches those seen in amorphous solid water as the liquid is cooled to the apparent singular temperature Ts≂−45 °C, for a variety of bulk properties. We use our Raman data to make an estimate of hydrogen bond probability and show that four bonded molecules would percolate near the singularity. We then argue that the collective mode grows because clusters of four bonded molecules grow in extent until at Ts percolation occurs to yield an infinite cluster with the amorphous solid’s collective spectrum.
On the Performance of Distributed and Cloud-Based Demand Response in Smart Grid (2017)

By locally solving an optimization problem and broadcasting an update message over the underlying communication infrastructure, demand response program based on the distributed optimization model encourage all users to participate in the program. However, some challenging issues present themselves, such as the existence of an ideal communication network, especially, when utilizing wireless communication, and the effects of communication channel properties, like the bit error rate, on the overall performance of the demand response program. To address the issues, this paper first defines a cloud-based demand response (CDR) model, which is implemented as a two-tier cloud computing platform. Then a communication model is proposed to evaluate the communication performance of both the CDR and distributed demand response models. This paper shows that when users are finely clustered, the channel bit error rate is high and the user datagram protocol (UDP) is leveraged to broadcast the update messages, making the optimal solution unachievable. Contradictory to UDP, the transmission control protocol will be caught up with a higher bandwidth and increase the delay in the convergence time. Finally, this paper presents a cost-effectiveness analysis which confirms that achieving higher demand response performance incurs a higher communication cost.
Pandemic intake questionnaire to improve quality, effectiveness, and efficiency of outpatient neurologic and developmental care at the Kennedy Krieger institute during the COVID-19 pandemic (2022)

This quality improvement project successfully implemented a pre-visit questionnaire to quickly assess areas of impact of COVID-19 on patients with neurodevelopmental disorders. During the pandemic, results identified several major areas of impact, including patient populations at increased risk for behavioral changes, sleep and/or disruptions of medical care. Most program directors reported improved patient care as a result.
Abstract 952: Protein kinase C theta (PKCθ) and c-Jun regulate proliferation through cyclin D1 in KIT-independent gastrointestinal stromal tumors (2011)

Abstract Oncogenic KIT or PDGFRA receptor tyrosine kinase (RTK) mutations are compelling therapeutic targets in gastrointestinal stromal tumors (GISTs), and the KIT/PDGFRA kinase inhibitor, imatinib, is standard of care for patients with metastatic GIST. However, most patients eventually develop clinical resistance to imatinib and other KIT/PDGFRA kinase inhibitors due to acquisition of secondary mutations in the KIT kinase domain, genomic amplification of KIT, or activation of alternate oncoproteins. Approximately 10% of KIT-dependent GIST metastases lose KIT expression at time of clinical progression during imatinib therapy. We performed whole transcriptome sequencing in KIT-expressing GIST vs. KIT-negative GIST, and thereby identified strong cyclin D1 expression only in KIT-negative GISTs. KIT-negative GISTs showed complete loss of the GIST biomarker, PKCθ, and restoration of PKCθ expression in these cells resulted in loss of Cyclin D1 expression. Lentivirus-mediated CCND1 (Cyclin D1) short hairpin RNA (shRNA) knockdown resulted in profound anti-proliferative and pro-apoptotic effects in KIT-negative GIST cell lines, and was associated with activation (dephosphorylation) of the tumor suppressor Rb and upregulation of the p27 CDK inhibitor. c-Jun expression levels paralleled the Cyclin D1 expression in the GIST lines, and c-Jun shRNA knockdown resulted in downregulation of cyclin D1 in the KIT-negative GIST lines, and was accompanied by profound anti-proliferative effects, including p27 upregulation, and pro-apoptotic effects as evidenced by PARP cleavage. By contrast, cyclin D1 and c-Jun silencing showed little anti-proliferative and pro-apoptotic effects in KIT-positive, KIT-dependent GIST lines. These findings show that cyclin D1 and c-Jun overexpression serve a crucial oncogenic role in KIT-independent GISTs, including those enabling clinical resistance to imatinib or sunitinib targeted kinase inhibitor therapies. Our findings also show that PKCθ downregulation and c-Jun upregulation coordinately enable cyclin D1 overexpression in KIT-independent GISTs. These novel findings highlight the relevance of c-Jun/cyclin D1 as novel therapeutic targets in GISTs that have lost KIT oncoprotein expression. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 952. doi:10.1158/1538-7445.AM2011-952
Fatty Acid Profile of the Initial Oral Biofilm (Pellicle): an In‐Situ Study (2013)

The first step of bioadhesion on dental surfaces is the formation of the acquired pellicle. This mainly acellular layer is formed instantaneously on all solid surfaces exposed to oral fluids. It is composed of proteins, glycoproteins and lipids. However, information on the lipid composition is sparse. The aim of the present study was to evaluate the fatty acid (FA) profile of the in-situ pellicle for the first time. Furthermore, the impact of rinses with safflower oil on the pellicle's FA composition was investigated. Pellicles were formed in situ on bovine enamel slabs mounted on individual upper jaw splints. The splints were carried by ten subjects over durations of 3-240 min. After comprehensive sample preparation, gas chromatography coupled with electron impact ionization mass spectrometry (GC-EI/MS) was used in order to characterize qualitatively and quantitatively a wide range of FA (C12-C24). The relative FA profiles of the pellicle samples gained from different subjects were remarkably similar, whereas the amount of FA showed significant interindividual variability. An increase in FA in the pellicle was observed over time. The application of rinses with safflower oil resulted in an accumulation of its specific FA in the pellicle. Pellicle formation is a highly selective process that does not correlate directly with salivary composition, as shown for FA.
Correlation of leakage-induced distortion with I-V characteristics in 1310-nm DFB lasers (1994)

The behavior of second-order intermodulation distortion (IMD2) versus laser bias is a strong indicator of analog distributed- feedback (DFB) laser chip and package performance. Although IMD2 is generally frequency dependent, low-frequency data provide information on modal stability, gain compression, spatial hole burning, leakage currents, optical cavity effects, and temperature effects. We propose here a simple model, based on easily measured dc parameters, that can be used to predict IMD2 performance in the case of lasers dominated by leakage current distortion. Measurements on approximately 100 DFB lasers confirm that the model describes the behavior of lasers having very nonlinear and temperature-dependent Id/V/d/ curves and strong dependence of distortion on bias current.
A Patient with a Large Aneurysm Complicated by Stenosis of the Internal Carotid Artery Distal to the Aneurysm in Whom Treatment Using a Pipeline Flex Was Performed (2020)

If Pipeline is deployed for patients with ICA stenosis just beyond an aneurysm, we need to be aware of in-stent stenosis after deployment.