gebhart/patrepeval huggingface dataset:
A coalitional game for femtocell clustering in OFDMA macro-femtocell networks (2016)

In this paper, we tackle the problem of resource management in macro-femtocell networks. Dense deployment of femtocells imposes several challenges for a cluster-based resource allocation. Some of those challenges are the trade-off between the level of offloaded traffic from macrocell and bandwidth allocated to femto-tier, the fair distribution of resources, and the mitigation of inter-cluster interference. To overcome these limitations, we propose a coalitional game to form clusters of femtocells that can reduce the resource allocation complexity. Stable clusters are formed based on the core model. Our proposal mainly consists of three components. Namely, a femtocell selection for public users, a coalitional game where cooperative femtocells are rewarded, and a Weighted Water Filling algorithm to allocate resources. Our solution is performed under a rewarding model, which is based on an ideal spectral efficiency and on an effective spectral efficiency. We compare the results of our rewarding model with a non-cooperative model, where femtocells work in closed access mode. Simulation results demonstrate that our proposal improves the femto-tier throughput and the satisfaction of femtocells subscribers.
Implementation of a relevance feedback method for content-based Music retrieval based on user preferences (2002)

Implementation of a relevance feedback method for content-based Music retrieval based on user preferences
Stimulation of creatine kinase specific activity in human osteoblast and endometrial cells by estrogens and anti-estrogens and its modulation by calciotropic hormones (1996)

We have previously demonstrated sex-specific stimulation of creatine kinase specific activity (CK) in bone cells both in vivo and in vitro, in primary culture cells derived from rat and human bone and in established human bone-derived cell lines. We found that the female-derived cell line, SaOS-2, responded to 17 beta-estradiol (E2) by increased CK specific activity. The effects of E2 on the CK activity in SaOS-2 cells was inhibited by 100-fold excess of 4-hydroxytamoxifen (Tam) as well as by the other antiestrogen, ICI 164,384. Tam by itself had some stimulatory effect whereas ICI 164,384 showed no estrogenic activity. We also demonstrated the estrogenic-like effect of another anti-estrogen, raloxifene (Ral), which is agonist only in the SaOS-2 osteoblast-like cells but not in the human endometrial, Ishikawa cell line. Ishikawa cells respond to E2 and to Tam by increased CK activity. In both osteoblasts and endometrial cell lines, Ral and Tam were inhibitory in the presence of E2. The effects of E2 on SaOS-2 cells are at least partially mediated by the estrogen receptor (ER) at the level of transcription as demonstrated by transient transfection experiments using the human creatine kinase promoter chloramphenicol acetyltransferase in these cells. Pretreatment of SaOS-2 with calcitropic hormones, either 1,25 dihydroxyvitamin D3 (1,25(OH)2D3) or human parathyroid hormone (1-34) (hPTH(1-34)) increased the stimulation of CK by E2 by 40-60% relative to E2 alone and significantly increased the sensitivity of the cells to E2 by lowering the effective hormonal dose needed for stimulation of CK by E2 by 100-fold. This stimulatory effect of pretreatment of the cells with 1,25(OH)2D3 was due to a 2.5-fold increase in the level of ER expression as measured directly by enzyme immunoassay in the SaOS-2/1 subline. The increase in the responsiveness to E2 by hPTH(1-34) was not due to an increase in ER level in the cells. We can conclude that in cell cultures as in vivo, Ral shows different effects depending on the cell type, namely estrogenic-like activity in skeletal cells but not in uterine cells. We can also conclude that as with rat-derived cells, in bone cells derived from human bone 1,25(OH)2D3 increased the sensitivity to E2 due to an increase in the number of ER in the cells, whereas PTH(1-34) augmented the response to E2 without increasing ER, by another, as yet unknown, mechanism. These studies suggest that the treatment of pathological bone disorders may be improved by combined hormone therapy.
Optical and Magnetic Properties of Fe-Doped GaN Diluted Magnetic Semiconductors Prepared by MOCVD Method (2008)

Fe-doped GaN thin films are grown on c-sapphires by metal organic chemical vapour deposition method (MOCVD). Crystalline quality and phase purity are characterized by x-ray diffraction and Raman scattering measurements. There are no detectable second phases formed during growth and no significant degradation in crystalline quality as Fe ions are doped. Fe-related optical transitions are observed in photoluminescence spectra. Magnetic measurements reveal that the films show room-temperature ferromagnetic behaviour. The ferromagnetism may originate from carrier-mediated Fe-doped GaN diluted magnetic semiconductors or nanoscale iron clusters and Fe-N compounds which we have not detected.
Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm (2016)

Bacterial spoilage of food products is regulated by density dependent communication system called quorum sensing (QS). QS control biofilm formation in numerous food pathogens and Biofilms formed on food surfaces act as carriers of bacterial contamination leading to spoilage of food and health hazards. Agents inhibiting or interfering with bacterial QS and biofilm are gaining importance as a novel class of next-generation food preservatives/packaging material. In the present study, Zinc nanostructures were synthesised using Nigella sativa seed extract (NS-ZnNPs). Synthesized nanostructures were characterized hexagonal wurtzite structure of size ~24 nm by UV-visible, XRD, FTIR and TEM. NS-ZnNPs demonstrated broad-spectrum QS inhibition in C. violaceum and P. aeruginosa biosensor strains. Synthesized nanostructures inhibited QS regulated functions of C. violaceum CVO26 (violacein) and elastase, protease, pyocyanin and alginate production in PAO1 significantly. NS-ZnNPs at sub-inhibitory concentrations inhibited the biofilm formation of four-food pathogens viz. C. violaceum 12472, PAO1, L. monocytogenes, E. coli. Moreover, NS-ZnNPs was found effective in inhibiting pre-formed mature biofilms of the four pathogens. Therefore, the broad-spectrum inhibition of QS and biofilm by biogenic Zinc oxide nanoparticles and it is envisaged that these nontoxic bioactive nanostructures can be used as food packaging material and/or as food preservative.
Integrity and Regeneration of Mechanotransduction Machinery Regulate Aminoglycoside Entry and Sensory Cell Death (2013)

Sound perception requires functional hair cell mechanotransduction (MET) machinery, including the MET channels and tip-link proteins. Prior work showed that uptake of ototoxic aminoglycosides (AG) into hair cells requires functional MET channels. In this study, we examined whether tip-link proteins, including Cadherin 23 (Cdh23), regulate AG entry into hair cells. Using time-lapse microscopy on cochlear explants, we found rapid uptake of gentamicin-conjugated Texas Red (GTTR) into hair cells from three-day-old Cdh23(+/+) and Cdh23(v2J/+) mice, but failed to detect GTTR uptake in Cdh23(v2J/v2J) hair cells. Pre-treatment of wildtype cochleae with the calcium chelator 1,2-bis(o-aminophenoxy) ethane-N,N,N',N'-tetraacetic acid (BAPTA) to disrupt tip-links also effectively reduced GTTR uptake into hair cells. Both Cdh23(v2J/v2J) and BAPTA-treated hair cells were protected from degeneration caused by gentamicin. Six hours after BAPTA treatment, GTTR uptake remained reduced in comparison to controls; by 24 hours, drug uptake was comparable between untreated and BAPTA-treated hair cells, which again became susceptible to cell death induced by gentamicin. Together, these results provide genetic and pharmacologic evidence that tip-links are required for AG uptake and toxicity in hair cells. Because tip-links can spontaneously regenerate, their temporary breakage offers a limited time window when hair cells are protected from AG toxicity.
Dynamic Modeling of Fine Coal Separations in a Hindered-bed Classifier (2000)

Abstract Hindered-bed classifiers have recently received significant attention for the potential of achieving effective density-based separations. Although the fundamental principles of hindered-bed classifiers are relatively simple, the complex interactions between the operating parameters provide a degree of difficulty that hinders the ability for on-line plant optimization. Thus, a dynamic population balance model was developed to evaluate and optimize the separation performance achievable on the basis of density by a hindered-bed classifier for the cleaning of fine coal. The steady-state results of the model include partition curves as a function of particle size and density as well as metallurgical data. A statistical comparison of the simulation results with those obtained from industrial units reveal a high level of accuracy with adjusted R2 values greater than 0.95. Simulation results indicate the potential for efficient density-based separations over a particle size range of 3:1.
Centrifuge modelling of heating effects on energy pile performance in saturated sand (2014)

The operation of energy piles in summer can expel excess heat of the buildings into the ground by the use of a heat pump. Despite having been implemented for decades, the design of energy piles still relies heavily on empiricism, as there is limited understanding about heating effects on pile capacity. A series of centrifuge model tests on aluminum energy piles in medium dense saturated sand is reported in this study to investigate heating effects on the settlement patterns as well as capacities of single piles. In total, four in-flight pile load tests under three different temperatures, namely 22, 37, and 52 °C, and different loading sequences were carried out. Variations of pile capacity were interpreted with the help of a nonlinear elastic analysis. The test results show that after heating at zero applied axial load, toe resistance of the pile was mobilized as a result of constrained downward thermal expansion of the pile. Heating to a higher temperature caused the neutral plane to shift towards the pile toe due to a larger degree of mobilization of end-bearing resistance. It is also found that for a pile under a maintained working load, the pile head heaved initially by 1.4%D (D, pile diameter) when the temperature increased by 30 °C, but it gradually settled to 0.8%D after 4 months of continuous heating at the constant temperature. The post-pile settlement is believed to be caused by thermal contraction of sand. Subsequent pile load tests show that pile capacities increased by 13% and 30% with incremental temperatures of 15 and 30 °C, respectively. With an increasing temperature, shaft resistance increased but at a reducing rate. At a higher elevated temperature, toe resistance increased more rapidly than shaft resistance due to a larger downward expansion of the pile. For simplicity, earth pressure coefficients with values of 1.1K 0 and 1.3K 0 were found to be suitable for estimating the capacities of aluminum model piles with temperature increments of 15 and 30 °C, respectively.
MiRNA-27a controls FBW7/hCDC4-dependent cyclin E degradation and cell cycle progression (2011)

The F-box protein FBW7/hCDC4 is a tumor suppressor that acts as the substrate recognition component of an SCF ubiquitin ligase that targets numerous oncoproteins for proteasomal degradation. In this study, we investigated whether FBW7 is regulated by microRNAs, using a screen combining bioinformatic analysis, luciferase reporters and microRNA libraries. The ubiquitous miR-27a was identified as a major suppressor of FBW7 and in line with this, miR-27a prohibited ubiquitylation and turnover of the key FBW7 substrate cyclin E. Notably, we found that miR-27a only suppresses FBW7 during specific cell cycle phases, relieving its negative impact at the G1 to S-phase transition, prior to cyclin E protein degradation. We also demonstrate that attenuation of FBW7 by miR-27a overexpression leads to improper cell cycle progression and DNA replication stress, consistent with dysregulation of cyclin E expression. Finally, in the context of human cancer, miR-27a was discovered to be generally overexpressed in pediatric B-ALL and its expression to be inversely correlated with that of FBW7 in hyperdiploid cases of B-ALL. These data provide evidence for microRNA-mediated regulation of FBW7, and highlight the role of miR-27a as a novel factor fine-tuning the periodic events regulating cell cycle progression.
RM3 Integration of Indium Phosphide Based 1.55 µm p-i-n Photodetectors with Silicon CMOS Optical Clock Receiver Circuits (2003)

Recess mounting with monolithic metalization RM3 integration of optoelectronic devices on CMOS can produce uniquely high performance OEICs. This paper describes the application of one RM3 technique, Alligned Pillar Bonding, to optical clock distribution.
Weighted least-squares criteria for seismic traveltime tomography (1989)

Methods are developed for design of linear tomographic reconstruction algorithms with specified properties. Assuming a starting model with constant slowness, an algorithm with the following properties is found: (1) the optimum constant for the starting model is determined automatically; (2) the weighted least-squares error between the predicted and measured traveltime data is as small as possible; (3) the variance of the reconstructed slowness from the starting model is minimized; (4) rays with the greatest length have the least influence on the reconstructed slowness, and (5) cells with most ray coverage tend to deviate least from the background value. The resulting algorithm maps the reconstruction problem into a vector space where the contribution to the inversion from the background slowness remains invariant, while the optimum contribution in orthogonal directions are found. For a starting model with constant slowness, the reconstruction algorithm has analogous properties.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Acute Airway Obstruction in a Patient Being Treated With Anticoagulation Therapy (2021)

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Unusual first-order magnetic phase transition and large magnetocaloric effect in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msub><mml:mi>Nd</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:mi>In</mml:mi></mml:mrow></mml:math> (2022)

A large magnetocaloric effect with its maximum near the boiling point of natural gas occurs in a rare-earth intermetallic compound ${\mathrm{Nd}}_{2}\mathrm{In}$. While behaviors of physical properties indicate that paramagnetic-ferromagnetic transformation supporting the large magnetocaloric effect is first order in nature, temperature-dependent crystallographic study reveals no changes in lattice symmetry and lack of discontinuities either in phase volume or lattice parameters. The borderline first-order nature of phase transformation in ${\mathrm{Nd}}_{2}\mathrm{In}$ is markedly different from conventional first-order magnetic transitions occurring in other members of the family -- isostructural ${\mathrm{Pr}}_{2}\mathrm{In}$ and nonisostructural ${\mathrm{Eu}}_{2}\mathrm{In}$.
Stress-Induced Secretion of Alpha-Melanocyte-Stimulating Hormone Is Accompanied by a Decrease in the Activity of Tuberohypophysial Dopaminergic Neurons (1991)

The purpose of the present study was to examine the acute effects of stress on the secretion of alpha-melanocyte-stimulating hormone (alpha MSH) and the activity of tuberohypophysial dopamine (DA) neurons in female and male rats. The activity of tuberohypophysial DA neurons was estimated by measuring the accumulation of 3,4-dihydroxyphenylalanine (DOPA) following administration of the decarboxylase inhibitor NSD 1015, and the concentrations of the DA metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) in the intermediate and neural lobes of the posterior pituitary. The combination of brief (2 min) ether exposure followed by 30 min of supine restraint (immobilization in the supine position) decreased the rate of DOPA accumulation in the intermediate, but not in the neural lobe of both female and male rats. Similarly, brief ether exposure followed by 10, 20 or 30 min of supine restraint increased plasma alpha MSH concentrations and decreased DOPAC concentrations in the intermediate lobe of female and male rats. In the absence of ether, tube restraint (confinement in a cylindrical acrylic tube) increased alpha MSH secretion and decreased intermediate lobe DOPAC concentrations, whereas ether in the absence of physical restraint had no effect. These results suggest that the stress-induced activation of alpha MSH secretion in both female and male rats may be due, in part, to a decrease in the activity of tuberohypophysial DA neurons in the intermediate lobe of the posterior pituitary.
Selective probing of ADP-ribosylation reactions with oxidized 2'-deoxynicotinamide adenine dinucleotide (1988)

A homogeneous preparation of an arginine-specific mono(ADP-ribosyl)transferase from turkey erythrocytes effectively utilized 2'-deoxy-NAD+ for the 2'-deoxy(ADP-ribose) modification of arginine methyl ester with an apparent Km of 27.2 microM and a Vmax of 36.4 mumol min-1 (mg of protein)-1. The adduct formed was also used as a substrate by an avian erythrocyte arginine(ADP-ribose)-specific hydrolase that generated free 2'-deoxy(ADP-ribose). In contrast, 2'-deoxy-NAD+ was not a substrate in the initiation or elongation reaction catalyzed by highly purified poly(ADP-ribose) polymerase from calf thymus. However, 2'-deoxy-NAD+ was a potent noncompetitive inhibitor of NAD+ in the elongation reaction catalyzed by the polymerase, with an apparent Ki of 32 microM. These results indicate that 2'-deoxy-NAD+ may be utilized to specifically identify protein acceptors for endogenous mono(ADP-ribosyl)transferases in complex biological systems that may contain a high activity of poly(ADP-ribose) polymerase, i.e., cell nuclei preparations.
Creation of Low Toxic Reverse‐Transcriptase Inhibitory Nucleosides that Prevent the Emergence of Drug‐Resistant HIV Variants (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Ganglioside GM3 Has an Essential Role in the Pathogenesis and Progression of Rheumatoid Arthritis (2012)

Rheumatoid arthritis (RA), a chronic systemic inflammatory disorder that principally attacks synovial joints, afflicts over 2 million people in the United States. Interleukin (IL)-17 is considered to be a master cytokine in chronic, destructive arthritis. Levels of the ganglioside GM3, one of the most primitive glycosphingolipids containing a sialic acid in the structure, are remarkably decreased in the synovium of patients with RA. Based on the increased cytokine secretions observed in in vitro experiments, GM3 might have an immunologic role. Here, to clarify the association between RA and GM3, we established a collagen-induced arthritis mouse model using the null mutation of the ganglioside GM3 synthase gene. GM3 deficiency exacerbated inflammatory arthritis in the mouse model of RA. In addition, disrupting GM3 induced T cell activation in vivo and promoted overproduction of the cytokines involved in RA. In contrast, the amount of the GM3 synthase gene transcript in the synovium was higher in patients with RA than in those with osteoarthritis. These findings indicate a crucial role for GM3 in the pathogenesis and progression of RA. Control of glycosphingolipids such as GM3 might therefore provide a novel therapeutic strategy for RA.
Protective Effects of Benidipine against Myocardial Damage Following Ischemia and Reperfusion in the Isolated Perfused Rat Heart. (1994)

We investigated the possible protective effects of benidipine (Coniel), a calcium antagonist, on mechanical dysfunction, metabolic damage and changes in vascular reactivity during ischemia and reperfusion in the Langendorff-perfused rat heart. The responses of perfusion pressure to U-46619, a vasoconstrictor, and acetylcholine, an endothelial-dependent vasodilator, were also determined as indices of the vascular function. Thirty min of reperfusion following 30 min of global ischemia produced contractile failure and the marked release of lactate dehydrogenase (LDH) and creatine phosphokinase (CPK). Additionally, the ischemia and reperfusion augmented the vasoconstrictor response to U-46619, and depressed the endothelium-dependent vasodilator response to acetylcholine. These hearts were treated with 1 or 10 nM benidipine from 20 min before ischemia to the beginning of ischemia. While benidipine at 10 nM had a modest negative inotropic action, 1 nM of this drug had minimal depressant effects on the preischemic function. The depressed contractile function after the ischemia was improved, and the increased releases of LDH and CPK were significantly ameliorated by benidipine. Also, benidipine restored the augmented contractile response to U-46619 and preserved the vasodilator response to acetylcholine. These results demonstrate that pretreatment with benidipine prevents myocardial injury following ischemia and reperfusion. The cardioprotective effects of benidipine may in part be due to the protection of vascular reactivity by this drug.
Total Synthesis of (±)-Decursivine via BINOL-Phosphoric Acid Catalyzed Tandem Oxidative Cyclization (2021)

Abstract Synthesis of tetracyclic indole alkaloid (±)-decursivine was accomplished through BINOL-phosphoric acid catalyzed tandem oxidative cyclization as a key step with hypervalent bis(trifluoroacetoxy)iodo)benzene (PIFA) as an oxidizing agent. This represents one of the shortest and highest yielding route for the synthesis of (±)-decursivine from readily available starting materials.
Multicenter Validation of Association Between Decline in MRI‐PDFF and Histologic Response in NASH (2020)

OCA was better than placebo in reducing liver fat. This multicenter trial provides data regarding the association between 30% decline in MRI-PDFF relative to baseline and histologic response in NASH.
Atypical presentation of pediatric mixed germ cell tumors in the sellar-suprasellar region (2012)

Intracranial germ cell tumors constitute a unique group of tumors, more often reported from the Asian region. Amongst them, the non-germinomatous variety occurs with a lesser frequency than the germinomatous variety. We report two children with mixed germ cell tumors with unusual clinical presentations: Central diabetes insipidus and recent-onset oculomotor palsy mimicking pituitary apoplexy. Unlike in adults, suprasellar lesions with a pituitary apoplexy-like picture in the pediatric age group may suggest a possibility of a mixed germ cell tumor.
Using Mined Patterns for XML Query Answering (2008)

XML is a rather verbose representation of semistructured data, which may require huge amounts of storage space. Several summarized representations of XML data have been proposed, which can both provide succinct information and be directly queried. In this chapter we focus on compact representations based on the extraction of association rules from XML datasets. In particular, we show how patterns can be exploited to (possibly partially) answer queries, either when fast (and approximate) answers are required, or when the actual dataset is not available, e.g., it is currently unreachable. We focus on (a) schema patterns, representing exact or approximate dataset constraints, (b) instance patterns, which represent actual data summaries, and their use for answering queries.