gebhart/patrepeval huggingface dataset:
Study of the regulation of the G2/M checkpoint in acute myeloid leukemia cell lines (2007)

AACR Annual Meeting-- Apr 14-18, 2007; Los Angeles, CA

4362 

Acute myelocytic leukemia (AML) cells exposed to genotoxic agents arrest their cell cycle at the G2/M checkpoint and are naturally chemoresistant. To gain insight in the understanding of this resistance, we compared the ability of immature CD34+ versus mature CD34- AML cell lines (KG1a and U937 respectively) to bypass a DNA damage cell cycle checkpoint in G2. Here, we report evidence for a more stringent control of G2/M checkpoint in KG1a than in U937 cells. We show that in both cell types the CDC25B phosphatase and the PLK1 kinase participate to the G2/M checkpoint recovery. We also show that inhibition of CHK1 by UCN-01 in immature KG1a cells allows checkpoint exit and sensibilisation to genotoxic agent. Finally, UCN-01 potentialises genotoxic-induced inhibition of plating efficiency of AML blasts from patients.

Together our results demonstrate that checkpoint stringency varies during maturation process and indicate that targeting checkpoint mechanisms might represent an attractive therapeutic opportunity for chemoresistant immature AML.
Endogenous Septic Shock by Combination of β-Glucan and NSAIDs (2005)

Concomitant Administration of β-Glucan and Indometacin.......................149 8.4 Increased Sensitivity to Endotoxin Due to ConcomitantAdministration of β-Glucan and Indometacin.............................................151 8.5 Effects of Nitric Oxide in the Appearance of Lethal Side EffectsCaused by β-Glucans ...................................................................................152 8.6 Strain Differences in Response to β-Glucans .............................................153 8.7 Conclusion....................................................................................................154 References..............................................................................................................156Nonsteroidal antiinflammatory drugs (NSAIDs) is the generic term for anti-inflammatory drugs that reduce pain and inflammation by suppressing the production of prostaglandins (PGs) as a result of cyclooxygenase (COX) inhibition (Dubois et al., 2004; Brooks, 2003; Mahmud et al., 2004; Kamat, 2003; Smithard, 2003; Swartz, 2003; Shah, 2003; FitzGerald, 2003; Weinberg, 2003; Mayrink et al., 2003). More than 30 million people around the world are using NSAIDs every day. Some 35 million prescriptions are written each year in the U.S. alone, and if single administrations are included, it is estimated that approximately 1.5% of the U.S. population uses NSAIDs. Moreover, some surveys in the U.S. and U.K. have revealed that NSAIDs account for approximately 5% of all prescriptions. It was first reported in the 1990s that there are two isotypes of COX that are inhibited by NSAIDs, namely COX1 and COX2, and that drugs selective for those two isotypes have been targeted in drug development (Gomez Cerezo et al., 2003; Mengle Gaw and Schwartz, 2002).Normally, COX2 is hardly found in any cells, and its expression is induced in inflammatory cells and cancer cells by stimulation with such substances as cytokines, hormones, and carcinogenic promoters. For this reason, PGs induced in this manner have been clearly demonstrated to be involved in inflammation, cell growth, vascularization, carcinogenesis, ovulation, and childbirth. On the other hand, PGs induced by the constitutive enzyme COX1 are thought to protect the body by protecting the gastric mucosa and maintaining normal kidney function.
Isolation and structure determination of the didemnenones, novel cytotoxic metabolites from tunicates (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIsolation and structure determination of the didemnenones, novel cytotoxic metabolites from tunicatesNiels. Lindquist, William. Fenical, David F. Sesin, Chris M. Ireland, Gregory D. Van Duyne, Craig J. Forsyth, and Jon. ClardyCite this: J. Am. Chem. Soc. 1988, 110, 4, 1308–1309Publication Date (Print):February 17, 1988Publication History Published online1 May 2002Published inissue 17 February 1988https://pubs.acs.org/doi/10.1021/ja00212a059https://doi.org/10.1021/ja00212a059research-articleACS PublicationsRequest reuse permissionsArticle Views280Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Figure S1 from miR-590-3p Promotes Ovarian Cancer Growth and Metastasis via a Novel FOXA2–Versican Pathway (2023)

&lt;p&gt;miR-590-3p promotes cell proliferation, migration, and invasion in multiple EOC cell lines.&lt;/p&gt;
Self-Assembly of Organic−Inorganic Hybrid Amphiphilic Surfactants with Large Polyoxometalates as Polar Head Groups (2008)

Mn-Anderson-C6 and Mn-Anderson-C16, A type of inorganic-organic hybrid molecules containing a large anionic polyoxometalate (POM) cluster and two C6 and C16 alkyl chains, respectively, demonstrate amphiphilic surfactant behavior in the mixed solvents of acetonitrile and water. The amphiphilic hybrid molecules can slowly assemble into membrane-like vesicles by using the POM clusters as polar head groups, as studied by laser light scattering and TEM techniques. The hollow vesicles have a typical bilayer structure with the hydrophilic Mn-Anderson cluster facing outside and long hydrophobic alkyl chains staying inside to form the solvent-phobic layer. Due to the rigidity of the POM polar heads, the two alkyl tails have to bend significantly for the vesicle formation, which makes the vesicle formation more difficult compared to some conventional surfactants. This is the first example of using hydrophilic POM macroions as polar head groups for a surfactant system.
Evolution of Firearm Violence over 20 Years: Integrating Law Enforcement and Clinical Data (2019)

Larger caliber and higher velocity firearms have significantly increased over the past 20 years in conjunction with injury severity, hospital days, and mean number of gun-related homicides per year (112 in 1996 to 2000 vs 143 in 2011 to 2015). Robust data sharing partnerships can be built between police and trauma centers to address the dearth of data on firearm crime and resulting injury.
Material Design Advancement Create Multifunctional Materials for Single-Layer Bonding and Debonding (2019)

Multifunctional materials are a relatively new topic in the semiconductor industry for wafer-level packaging (WLP). With the increase in processing steps and the emergence of more advanced technologies, the use of multifunctional materials will become a more integral part in the future of temporary bonding and debonding (TB/DB) as well as other advanced packaging applications. One approach to multifunctional material design incorporates adhesive and laser release attributes in one material layer. Although this is similar to a thermal release material, it has greater thermal capabilities due to its ability to be cured and undergo laser debond. Many advantages may be obtained by combining a curable adhesive and laser release layer into one material. One of the greatest advantages is the reduction in overall processing time and steps required to bond wafer pairs as well as the reduction of chemical waste, due to the use of one material compared to two or more materials which significantly reduces the cost of ownership. Curable adhesive single layer systems offer access to higher temperatures with less material flow from the curable layer, strong adhesion for high stress applications where wafers can delaminate or spontaneously debond when using multilayer mechanically debonding systems such as Fan-Out Wafer Level Packaging (FOWLP), and offer lower wafer stress and warpage due to fewer material interfaces within the bonded wafer pairs causing less potential mismatch of materials coefficient of thermal expansion(CTE). Some challenges with this concept stem from the concern of the cleanability of a curable layer and potential laser damage to the device. In order to wet clean a curable layer, which is usually very solvent resistant due to the crosslinked nature, requires harsh solvent based solutions (that may contain either strong acid or base, require long cleaning time, and high temperature). This study will address all of the aforementioned challenges and includes the developmental advancements in material designs that resulted in the creation of new multifunctional materials. These multifunctional materials have been designed to be thermally curable, prevent material reflow of the bonding layer at higher temperatures, while still remaining wet cleanable without the use of harsh chemicals and long times. As with any material that utilize laser release methods there are concerns about device damage from laser energy penetrating to the device but multifunctional materials address this in two ways: they offer high absorbance of the laser energy at all commercially available laser tool wavelengths and they can be utilized as a thicker film as they act as the bonding layer as well. By overcoming their challenges, they will minimize the cost of ownership while driving advancement in future materials and processing.
A Highly Active, Isospecific Cobalt Catalyst for Propylene Oxide Polymerization (2005)

A highly active cobalt complex ((salph)CoOAc; salph = N,N'-bis(3,5-di-tert-butylsalicylidine-1,2-benzenediamine)) was discovered for the isospecific polymerization of rac-propylene oxide.
Viscoelastic properties and phase behavior of 12‐<i>tert</i>‐butyl ester dendrimer/poly(methyl methacrylate) blends (2001)

Abstract This study used refractometry, ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, and dielectric analysis to assess the viscoelastic properties and phase behavior of blends containing 0–20% (w/w) 12‐ tert ‐butyl ester dendrimer in poly(methyl methacrylate) (PMMA). Dendritic blends were miscible up through 12%, exhibiting an intermediate glass‐transition temperature ( T g ; α) between those of the two pure components. Interactions of PMMA CO groups and dendrimer NH groups contributed to miscibility. T g decreased with increasing dendrimer content before phase separation. The dendrimer exhibited phase separation at 15%, as revealed by Rayleigh scattering in ultraviolet–visible spectra and the emergence of a second T g in dielectric studies. Before phase separation, clear, secondary β relaxations for PMMA were observed at low frequencies via dielectric analysis. Apparent activation energies were obtained through Arrhenius characterization. A merged αβ process for PMMA occurred at higher frequencies and temperatures in the blends. Dielectric data for the phase‐separated dendrimer relaxation (α D ) in the 20% blend conformed to Williams–Landel–Ferry behavior, which allowed the calculation of the apparent activation energy. The α D relaxation data, analyzed both before and after treatment with the electric modulus, compared well with neat dendrimer data, which confirmed that this relaxation was due to an isolated dendrimer phase. © 2001 John Wiley &amp; Sons, Inc. J Polym Sci Part B: Polym Phys 39: 1381–1393, 2001
Data from Genetic Profiling of Epithelial Cells Expressing E-Cadherin Repressors Reveals a Distinct Role for Snail, Slug, and E47 Factors in Epithelial-Mesenchymal Transition (2023)

&lt;div&gt;Abstract&lt;p&gt;The transcription factors Snail, Slug, and bHLH E47 have been recently described as direct repressors of &lt;i&gt;E-cadherin&lt;/i&gt; and inducers of epithelial-mesenchymal transition (EMT) and invasion when overexpressed in epithelial cells. Although a role of those factors in tumor progression and invasion has been proposed, whether the different repressors play distinct or redundant roles in the tumorigenic process has not been established. To further investigate this important issue, we have analyzed the gene expression profiling of Madin-Darby canine kidney (MDCK) epithelial cells expressing the different repressors (MDCK-Snail, MDCK-Slug, and MDCK-E47 cells) versus control MDCK cells by cDNA microarrays. A total of 243 clones (228 genes and 15 expressed sequence tags) were found to be differentially expressed between either of the three MDCK-derived cell lines and control MDCK cells. Twenty two of the candidate genes were validated by Northern blot, Western blot, immunofluorescence, and promoter analyses in cell lines and by immunohistochemistry in xenografted tumors. Gene clustering analysis indicated that about a third of the 243 candidate genes were common to MDCK cells expressing Snail, Slug, or E47 factors, whereas the rest of the genes were regulated in only one or two cell types. Differentially regulated genes include those related to EMT (45 genes), transcriptional regulation (18 genes), cell proliferation and signaling (54 genes), apoptosis (12 genes), and angiogenesis (9 genes). These results indicate that Snail, Slug, and E47 transcription factors induce common and specific genetic programs, supporting a differential role of the factors in tumor progression and invasion. (Cancer Res 2006; 66(19): 9543-56)&lt;/p&gt;&lt;/div&gt;
1P2-P02 Execution and Evaluation of Mechatronics Education Using Line Tracing Robots : Activity report of the class in 2014 (2015)

We are developing mechatronics education program using line tracing robots which are controlled by microcomputer. This program is applied to the new students as an introductory course of engineering experience. The class consists of hardware, software development of the robot, and its evaluation. We strongly recommended to the students to develop a new robot with original features. For examples, at the beginning of the class, we invited our OB and had a lecture about the importance of originality. As a result, more than half students developed various robots with original features.
New perspectives on the role of muscarinic antagonists in asthma therapy (2020)

New evidence indicates that the effectiveness of adding a LAMA, at least tiotropium, is independent of the degree of the type 2 inflammation and age of patient. Therefore, tiotropium can be administered without the need for patient phenotyping. Umeclidinium and glycopyrronium also appear effective in asthma. Initial treatment with LAMA+ICS for those with mild asthma may be an equally effective therapeutic option as LABA+ICS but this hypothesis should be confirmed by statistically powered trials.
Nucleation-Controlled Metal-Induced Lateral Crystallization of Amorphous Si<sub>1-x</sub>Ge<sub>x</sub> with Whole Ge Fraction on Insulator (2008)

The effects of Ge fraction and annealing temperature on the metal-induced lateral crystallization (MILC) of amorphous SiGe films on an insulator have been investigated. It was shown that the progress of the MILC of amorphous SiGe was suppressed by spontaneous nucleation, which was accelerated with increases in Ge fraction and annealing temperature. Thus, MILC could not proceed for amorphous SiGe with high Ge fractions (>70%) at high temperatures (>500 °C). Spontaneous nucleation was significantly suppressed by lowering the annealing temperature (<400 °C). As a result, the MILC of amorphous SiGe was achieved for samples with whole Ge fractions (0–100%), and large polycrystalline silicon–germanium (poly-SiGe) regions (>20 µm) could be realized for even high Ge fractions (>70%). Transmission electron microscopy suggested that the mechanism of MILC of amorphous SiGe (a-SiGe) with medium and high Ge fractions (>40%) is different from that of a-Si.
Electrochemical Behaviors of Binary and Ternary Manganese Phosphides. (2006)

Abstract For Abstract see ChemInform Abstract in Full Text.
Service Networks Modelling: An SOA & BPM Standpoint (2010)

Services are quintessential in the current economical landscape. Enterprises and businesses at large rely on the consumption and providing of services to ensure their operations and to realize their business offers. That is, nowadays businesses all over the world are interconnected with each other by complex service-centric webs called service networks. The ubiquity and pervasiveness of service networks call for models, methods, mechanisms and tools to understand them and harness their potential. This paper investigates the modelling of the service networks with a focus on business relationships and exchanges of software services among the involved parties. The contribution of this work is threefold. Firstly, we provide an overview of what service networks modelling can offer in combination with Business Process Management (BPM) and Service Oriented Architecture (SOA) technologies. Secondly, we propose a formalism to model service networks that depicts them as aggregations of participants - e.g. enterprises or individuals - that offer, request, consume and provide services to each other. With the goal of providing a foundation for the alignment between service network- and business process models, we finally map the constructs of our service networks modelling formalism to the ones of the Business Process Modelling Notation (BPMN).
Modelling the relationship between urban environment and travel behaviour: policy and indicators (2012)

Due to the necessity to undertake activities, every year people increase their standards of travelling (distance and time). Urban sprawl development plays an important role in these "enlargements". Thus, governments invest money in an exhaustiva search for solutions to high levels of congestion and car-trips. The complex relationship between urban environment and travel behaviour has been studied in a number of cases. Thus, the objective of this paper is to answer the important question of which land-use attributes influence which dimensions of travel behaviour, and to verify to what extent specific urban planning measures affect the individual decision process, by exhaustiva statistical and systematic tests. This paper found that a crucial issue in the analysis of the relationship between the built environment and travel behaviour is the definition of indicators. As such, we recommend a feasible list of indicators to analyze this relationship.
Tolerances in micro manufacturing (2017)

This paper describes a method for analysis of tolerances in micro manufacturing. It proposes a mapping oftolerances to dimensions and compares this with current available international standards. The analysisdocuments that tolerances are not scaled down as the absolute dimension. In practice a tolerance level of 10 -100 μm seems to be the preferred level no matter the absolute dimension.
Reactions to Mixed-Context Always-On Video for Connecting Close Personal and Work Contacts (2014)

Commercial video chat systems are now commonplace in people’s lives where they are used for a combination of work and personal needs. Most are designed for conversation-style interactions where people ‘call ’ each other and converse. This paper explores an alternative design paradigm of ‘always-on ’ video connections for communicating with both personal and work contacts. We conducted an online survey with forty-five respondents that investigates people’s reactions to such technology followed by a four-week field trial with five participants who used a fully functional mixed-context media space. Our results show that many people saw value in such a system, yet had reservations about the ‘always-on ’ nature. Most said they would use it in observational situations. Field trial participants also faced challenges with an automated audio channel and a lack of dedicated devices. The implications are that while such systems can provide an easier communication channel, concerns with distractions, trust, and privacy should be mitigated within the design. ACM Classification Keywords H.5.m. Information interfaces and presentation (e.g., HCI):
On-surface synthesis of polyazulene with 2,6-connectivity (2019)

Azulene, the smallest neutral nonalternant aromatic hydrocarbon, serves not only as a prototype for fundamental studies but also as a versatile building block for functional materials because of its unique opto(electronic) properties. Here, we report the on-surface synthesis and characterization of the homopolymer of azulene connected exclusively at the 2,6-positions using 2,6-diiodoazulene as the monomer precursor. As an intermediate to the formation of polyazulene, a gold-(2,6-azulenylene) chain is observed.
Atomistic mechanism leading to complex antiferroelectric and incommensurate perovskites (2016)

An atomic interaction is identified in all perovskite compounds, such as $AB{\mathrm{O}}_{3}$ oxides, that can potentially result in unconventional structures. The term is harmonic in nature and couples the motions of the $A$ cations with the rotations of the oxygen octahedra in the perovskite lattice. When strong enough, this coupling leads to hybrid normal modes that present both (anti)polar and rotational characters, which are keys to understand a variety of exotic phases. For example, we show that not only does this new coupling explain the long-period soft phonons characterizing prototype antiferroelectric ${\mathrm{PbZrO}}_{3}$, but it also provides us with an unified description of the complex antipolar structures of a variety of perovskites, including the possible occurrence of incommensurate phases. This coupling is further demonstrated to result, in the continuum limit, in an energy invariant adopting an analytical form that has been previously overlooked, to the best of our knowledge.
Ablação Septal com Cateteres e Radiofrequência Guiada pela Ecocardiografia para Tratamento de Pacientes com Cardiomiopatia Hipertrófica Obstrutiva: Experiência Inicial (2021)

The TEE-guided septal ablation was efficient and safe, and the results were maintained during the clinical follow-up period. It is a reasonable option for the interventionist treatment of LVOT obstruction in HCM.
Compilation and equivalence of imperative objects (1999)

We adopt the untyped imperative object calculus of Abadi and Cardelli as a minimal setting in which to study problems of compilation and program equivalence that arise when compiling object-oriented languages. We present both a big-step and a small-step substitution-based operational semantics for the calculus. Our first two results are theorems asserting the equivalence of our substitution-based semantics with a closure-based semantics like that given by Abadi and Cardelli. Our third result is a direct proof of the correctness of compilation to a stack-based abstract machine via a small-step decompilation algorithm. Our fourth result is that contextual equivalence of objects coincides with a form of Mason and Talcott's CIU equivalence; the latter provides a tractable means of establishing operational equivalences. Finally, we prove correct an algorithm, used in our prototype compiler, for statically resolving method offsets. This is the first study of correctness of an object-oriented abstract machine, and of operational equivalence for the imperative object calculus.