gebhart/patrepeval huggingface dataset:
Glutamate controls vessel-associated migration of GABA interneurons from the pial migratory route via NMDA receptors and endothelial protease activation (2019)

During cortex development, fine interactions between pyramidal cells and migrating GABA neurons are required to orchestrate correct positioning of interneurons, but cellular and molecular mechanisms are not yet clearly understood. Functional and age-specific expression of NMDA receptors by neonate endothelial cells suggests a vascular contribution to the trophic role of glutamate during cortical development. Associating functional and loss-of-function approaches, we found that glutamate stimulates activity of the endothelial proteases MMP-9 and t-PA along the pial migratory route (PMR) and radial cortical microvessels. Activation of MMP-9 was NMDAR-dependent and abrogated in t-PA<sup>-/-</sup> mice. Time-lapse recordings revealed that glutamate stimulated migration of GABA interneurons along vessels through an NMDAR-dependent mechanism. In Gad67-GFP mice, t-PA invalidation and in vivo administration of an MMP inhibitor impaired positioning of GABA interneurons in superficial cortical layers, whereas Grin1 endothelial invalidation resulted in a strong reduction of the thickness of the pial migratory route, a marked decrease of the glutamate-induced MMP-9-like activity along the PMR and a depopulation of interneurons in superficial cortical layers. This study supports that glutamate controls the vessel-associated migration of GABA interneurons by regulating the activity of endothelial proteases. This effect requires endothelial NMDAR and is t-PA-dependent. These neurodevelopmental data reinforce the debate regarding safety of molecules with NMDA-antagonist properties administered to preterm and term neonates.
Novel chemically amplified dry-developing imaging materials for high resolution microlithography. (1992)

Several new polymers, copolymers, and polyfunctional crosslinkers that can be used to formulate chemically amplified resist materials have been prepared, characterized, and tested in combination with suitable photoactive compounds. All of the materials operate on the basis of acid catalyzed processes involving alkylation, dehydration, or isomerization reactions. Sensitivities below 0.1mJ/cm2 have been measured with deep-UV irradiation, while most of the materials also operate very effectively with E-beam or X-ray exposure. The resist materials are useful in dry development and top-surface imaging processes. Depending on the nature of the matrix polymer and the design of the resist material, both positive and negative tone images can be obtained. Dry development using an oxygen plasma can be achieved following selective silylation of the resists after exposure and post-baking. Those areas of the films that are silylated resist etching by the oxygen plasma providing access to high resolution images that also benefit from the high sensitivity of the chemically amplified resists.
A 700-V Device in High-Voltage Power ICs With Low On-State Resistance and Enhanced SOA (2013)

This paper presents a 700-V high-voltage laterally diffused metal-oxide–semiconductor (LDMOS) field-effect transistor with a p-body_Extension reduce surface field (RESURF) structure. Experimental results demonstrate that the low ON resistance and breakdown voltage (BV)- <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$R_{\rm{ON},sp}$</tex></formula> figure of merit approach the ideal Baliga's power law, in addition, breaks the quasi-saturation limitation with enhanced device safe operating area (SOA). The optimal charge balance and geometrical design to achieve the lowest specific ON resistance <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$(R_{\rm{ON},sp})$</tex></formula> with the desired maximum high BV are displayed and discussed by simulations and experimental results. The 2-D simulations confirmed that, compared with conventional triple-RESURF structures, the presented device provides a fourfold reduction in the surface electric field on the source side and a 32% improvement in blocking voltage. The specific ON resistance demonstrates superior 40% lower performance than published Junction Isolation LDMOS device families. In addition, its twofold increase in SOA extension can improve the performance of circuit designs for switching power supply applications.
Ultraviolet sunscreens in reef fish mucus (2008)

MEPS Marine Ecology Progress Series Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsTheme Sections MEPS 353:203-211 (2008) - DOI: https://doi.org/10.3354/meps07210 Ultraviolet sunscreens in reef fish mucus Maxi J. Eckes1,*, Ulrike E. Siebeck2, Sophie Dove3, Alexandra S. Grutter1 1School of Integrative Biology, University of Queensland, St. Lucia, Queensland 4072, Australia 2Sensory Neurobiology Group, School of Biomedical Sciences, University of Queensland, St. Lucia, Queensland 4072, Australia 3Centre for Marine Studies, ARC Centre of Excellence for Coral Reef Studies, University of Queensland, St. Lucia, Queensland 4072, Australia *Email: m.eckes@uq.edu.au ABSTRACT: Coral reef fishes were recently discovered to have ultraviolet (UV) radiation screening compounds, most commonly known as mycosporine-like amino acids (MAAs), in their external body mucus. However, little is known about the identity and quantity of MAAs in the mucus of reef fishes or what factors affect their abundance and distribution. Using spectrophotometry, we examined the relative field UV absorbance of fresh mucus and quantified the UV absorbance per mg of mucus using laboratory UV absorbance for 7 species of reef fishes (Labroides dimidiatus and Thalassoma lunare [Labridae]; Chlorurus sordidus, Scarus flavipectoralis, S. niger, S. rivulatus, and S. schlegelii [Scaridae]) from Queensland, Australia. For the first time in fish mucus, we identified and quantified MAAs using High Performance Liquid Chromatography. In addition, to examine geographical variation in MAAs, MAA absorbance in T. lunare mucus was compared among 3 different locations (Lizard Island, Heron Island, and North Stradbroke Island) on the coast of Queensland. The mucus of all fish investigated contained MAAs. Depending on the species, different combinations and quantities of the MAAs asterina-330, palythene and mycosporine-N-methylamine serine were present. UV absorbance and MAA levels in mucus of T. lunare from North Stradbroke Island were lower (mycosporine-N-methylamine serine) or absent (palythene) compared with mucus from Lizard Island and Heron Island. This study shows that the identity and quantity of MAAs in fish mucus not only varies among species but also within a species sampled in different locations. This suggests that the ecological role of MAAs in fishes is varied and complex and that several factors may affect the type and quantity of MAAs found in the mucus of reef fishes. KEY WORDS: Mycosporine-like amino acids · MAA · Fish mucus · Geographical comparison · UV absorbance · UV protection Full text in pdf format PreviousNextCite this article as: Eckes MJ, Siebeck UE, Dove S, Grutter AS (2008) Ultraviolet sunscreens in reef fish mucus. Mar Ecol Prog Ser 353:203-211. https://doi.org/10.3354/meps07210 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in MEPS Vol. 353. Online publication date: January 17, 2008 Print ISSN: 0171-8630; Online ISSN: 1616-1599 Copyright © 2008 Inter-Research.
Analysis of signal-to-noise ratio distributions and bit error rates for equal gain diversity systems on generalized fading channels (1990)

An infinite series for the complementary probability distribution function of the signal-to-noise ratio at the output of L-branch equal-gain diversity combiners in Nakagami fading channels is derived. The bit error rate for a matched-filter receiver is analyzed for the combiner and different fading parameters. Both coherent phase-shift keying and differential coherent phase-shift keying are considered. The effects of gain unbalance between branches on the probability distribution of the SNR and on the bit error rates are investigated. Bit-error-rate results are also obtained for coherent and noncoherent reception of frequency-shift keying. The effects of gain unbalances on FSK modulations are also investigated. It is shown that, even with -20 dB (k=0.01) gain unbalance between the branches of a dual combiner, there is still a considerable improvement over the nondiversity instance for the generalized fading model (m=1).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fit analysis using live and 3D scan models (2010)

Purpose The purpose of this paper is to develop a “good fit” for garments for customer satisfaction, comfort, and functionality as well as a manufacturer's success and reputation. Design/methodology/approach This paper reviews and evaluates garments on a live fit model and makes recommendations for the acceptance or modification of the garment for production. As more manufacturing, product development, and designing responsibilities continue to take place globally, alternatives to the traditional fit analysis are under consideration. Findings Fit analysis using live and three‐dimensional scan models as an alternative to the traditional fit analysis are under consideration. Originality/value This paper evaluates garments on a live fit model and makes recommendations for the acceptance or modification of the garment for production.
Supplementary Figure S4 from Endo180 (&lt;i&gt;MRC2&lt;/i&gt;) Antibody–Drug Conjugate for the Treatment of Sarcoma (2023)

&lt;p&gt;Composition and drug to antibody ratio of A5/158 and the isotype control antibody conjugated to vc-MMAE. This figure additionally shows that that conjugation of A5/158 and the isotype control antibody to vc-MMAE does not induce antibody aggregation or disrupt Endo180 protein recognition.&lt;/p&gt;
Structural basis for recognition of intron branchpoint RNA by yeast Msl5 and selective effects of interfacial mutations on splicing of yeast pre-mRNAs (2015)

Saccharomyces cerevisiae Msl5 orchestrates spliceosome assembly by binding the intron branchpoint sequence 5'-UACUAAC and, with its heterodimer partner protein Mud2, establishing cross intron-bridging interactions with the U1 snRNP at the 5' splice site. Here we define the central Msl5 KH-QUA2 domain as sufficient for branchpoint RNA recognition. The 1.8 Å crystal structure of Msl5-(KH-QUA2) bound to the branchpoint highlights an extensive network of direct and water-mediated protein-RNA and intra-RNA atomic contacts at the interface that illuminate how Msl5 recognizes each nucleobase of the UACUAAC element. The Msl5 structure rationalizes a large body of mutational data and inspires new functional studies herein, which reveal how perturbations of the Msl5·RNA interface impede the splicing of specific yeast pre-mRNAs. We also identify interfacial mutations in Msl5 that bypass the essentiality of Sub2, a DExD-box ATPase implicated in displacing Msl5 from the branchpoint in exchange for the U2 snRNP. These studies establish an atomic resolution framework for understanding splice site selection and early spliceosome dynamics.
Concordance of genomic alterations by next generation sequencing (NGS) in tumor tissue vs. cell-free DNA in advanced breast cancer. (2016)

11528 Background: Cell-free DNA (cfDNA) is a non-invasive method of assessing mutations in the blood. This study compared the concordance between cfDNA and tissue biopsies across DNA genomic alterations in patients with advanced breast cancer (ABC). Methods: Forty-five patients with ABC who had both NGS testing with cfDNA (Guardant) and tissue DNA (Foundation One) for clinical management were included. 45-67 genes were common to both assays depending on when the assays were performed. Concordance was defined as the presence or absence of the identical genomic sequencing alteration(s) in a single gene. Results: Median time between assays was 3.3 months [range, 0-67 months]. Including all alterations and variants of unknown significance, the average number per patient for tissue and cfDNA was 4.50 (SD 2.96) and 1.98 (SD 2.13), respectively. Concordance between the two assays was 91.2%. Among only genes with reported genomic alterations in either assay (N=232), concordance was 10.3%. 15.0% of alterations found in tissue were detected in cfDNA. 34.1% of cfDNA mutations were detected in tumor biopsies. Across 5 clinically important genes, sensitivity and specificity were 26.8% and 95.3%, respectively, with a diagnostic accuracy of 71.6% (Table). Conclusions: This study demonstrated a high concordance between tissue and cfDNA NGS. Moreover, a larger number of mutations were detected by tissue NGS. Potential reasons include different sequencing techniques, spatial and temporal factors, tumor heterogeneity, subclones, and potential germline DNA contamination. The study suggests that both tissue and blood-based NGS can be used to describe the complex biology of ABC. Diagnostic accuracy of 5 genes associated with breast cancer. cfDNA mutations Tissue Mutations Sensitivity (%) Specificity (%) PPV (%) NPV (%) Diagnostic Accuracy (%) (+) (-) TP53 (+) 7 2 (-) 17 16 29.2 88.9 77.8 48.5 54.8 PIK3CA (+) 3 2 (-) 9 31 25.0 93.9 60.0 77.5 75.6 ERBB2 (+) 4 0 (-) 10 31 28.6 100.0 100.0 75.6 77.8 BRCA1 (+) 1 0 (-) 2 12 33.3 100.0 100.0 85.7 86.7 BRCA2 (+) 0 1 (-) 3 11 0.0 91.7 0.0 78.6 73.3 Total positive 15 5 Total negative 41 101 Total (positive + negative) 56 106 26.8 95.3 75.0 71.1 71.6 * Chae & Davis: equal contribution
Considering Source Dynamics in Computer-Aided Parameteric Average-Value Modeling of PWM Converters (2006)

Average-value modeling of PWM converters has received significant attention in the literature, wherein the computer-aided methodologies appear to be particularly promising. A numerical procedure has recently been proposed that avoids excessive analytical derivations and results in fairly accurate dynamic average-value models that include effects of parasitics. This methodology is extended here to account for input source dynamics. In particular, the so-called duty-ratio constraint and correction matrix are expressed as nonlinear functions of the duty cycle and the new quantity defined through the averaged dynamic impedance of the switching cell. The resulting model is shown to be accurate in predicting large-signal time-domain transients and small-signal frequency-domain characteristics
Programmable Conductivity of Silicon Nanowires with Side Gates by Surface Charging (2003)

Silicon nanowires with programmable conductivity which utilized sensitivity of conductance to surface charging have been investigated in terms of complementary operation of p- and n-type devices. The device fabricated from a silicon-on-insulator (SOI) wafer consists of a nanowire (width ≈ 30 nm) and side gates for control of surface charging onto the nanowire. The wire current clearly exhibited hysteresis by sweeping the side gate voltage at a constant rate. The transistor characteristics obtained using the SOI substrate as a back gate also exhibited programmable threshold voltage by applying a pulse bias to the side gate. Surface potential imaging of the nanowire by means of scanning Maxwell-stress microscopy (SMM) has been carried out for correlating the programmability to surface charging. The SMM images clearly explained the origin of the programmability and the complementary operation of the p- and n-type nanowires.
Select Dietary Fibers Alter GI Microbiome Composition &amp; Promote Fermentative Metabolism in the Lower Gastrointestinal Tract of Healthy Adult Dogs (P20-044-19) (2019)

The canine gastrointestinal (GI) microbiome is capable of fermenting fibers. We evaluated select dietary plant fibers on canine GI microbiome composition & metabolism. 39 adult dogs were fed a control food (CF) for 4 weeks, then fed a test food (TF) for 4 weeks. (CF: 3411 kcals/kg, 2.2 g total dietary fiber, TDF; 0.5 g soluble fiber, SF; 1.7 g insoluble fiber, INSF per 100 kcal; TF: 3273 kcal/kg, 5.0 g TDF, 0.8 g SF, 4.2 g INSF per 100 kcal). Foods were complete & balanced dry foods & met 2017 AAFCO nutritional guidelines. CF fiber sources: cracked pearled barley, whole corn, whole grain oats, cellulose; TF: cracked pearled barley, whole corn, whole grain oats, ground pecan shells, cellulose, flaxseed, dried beet pulp, dried citrus pulp, pressed cranberries, dried pumpkin, psyllium seed husks, & ginger root. Feces were collected after 4 weeks of feeding CF and TF, homogenized, & frozen at −80C within 1 hour of defecation. Fecal microbiome 16 s rRNA sequencing was performed using Illumina MiSeq and processed through Mothur. Predicted microbial functions were determined by PICRUSt and analyzed using PERMANOVA. Count-normalized data were CLR transformed & analyzed using negative binomial mixed models. Fecal short chain fatty acids (SCFA) were analyzed using liquid-liquid extraction & gas chromatography with flame ionization detection. Results significant at P < 0.05 are reported. The study was reviewed & approved by the Institutional Animal Care & Use Committee, Hill’s Pet Nutrition, Inc. Dogs had access to clean fresh water at all times. TF significantly increased fecal acetic acid, decreased putrefactive metabolites such as isobutyric, 2-methylbutyric, & isovaleric acids. The acetate-& lactate-producing genera Bacteroides and Faecalibacterium were significantly increased while Streptococus and Enterococcus were significantly decreased vs CF. Predicted microbial functions representing butyrate, phenylalanine & tyrosine metabolic pathways were significantly different from CF. TF shifts canine GI microbiome composition and metabolism toward saccharolytic fermentation & decreases putrefactive metabolites, characteristics which provide beneficial impacts to canine GI health. This study was funded by Hill’s Pet Nutrition, Inc.
Global Finish Machining Using CM<sup>2</sup> (2006)

Computer-Aided Design and Applications is an international journal on the applications of CAD and CAM. It publishes papers in the general domain of CAD plus in emerging fields like bio-CAD, nano-CAD, soft-CAD, garment-CAD, PLM, PDM, CAD data mining, CAD and the internet, CAD education, genetic algorithms and CAD engines. The journal is aimed at all developers and users of CAD technology to ptovide CAD solutions for various stages of design and manufacturing. The journal publishes all about Computer-Aided Design and Computer-Aided technologies.
Synthesis and characterization of a novel extra large pore aluminophosphate molecular sieve, NCL-6 (2005)

Catalysis Division, National Chemical Laboratory, Pune-411 008, India <em>E-mail</em>: venkat@cata.ncl.res.in Fax: 91-20-5893761 <em>Manuscript received 10 July 2003, revised 12 April 2004, accepted 30 August 2004</em> A novel extra large pore aluminophosphate molecular sieve NCL-6, has been prepared and characterized by various techniques such as XRD, SEM, TG/DTA, carbon and nitrogen analysis, FT-IR and MAS NMR are reported. X-Ray diffraction pattern shows that the synthesized sample is crystalline and have novel structure. SEM analysis indicate the phase purity and having granules morphology with 3 x 5 µm particle size. FT-IR spectrum in the framework region shows that the sample is similar to the other known aluminophosphates. TG/DTA shows that the sample losses 30.45% due to the loss of water and organic molecules. Aluminium and phosphorous NMR shows that the presence of four different aluminium and three different phosphorous sites. The NMR are similar to VPl-5, NCL-2 and NCL-3.
Inorganic Ligand Thiosulfate-Capped Quantum Dots for Efficient Quantum Dot Sensitized Solar Cells (2017)

The insulating nature of organic ligands containing long hydrocarbon tails brings forward serious limitations for presynthesized quantum dots (QDs) in photovoltaic applications. Replacing the initial organic hydrocarbon chain ligands with simple, cheap, and small inorganic ligands is regarded as an efficient strategy for improving the performance of the resulting photovoltaic devices. Herein, thiosulfate (S<sub>2</sub>O<sub>3</sub><sup>2-</sup>), and sulfide (S<sup>2-</sup>) were employed as ligand-exchange reagents to get access to the inorganic ligand S<sub>2</sub>O<sub>3</sub><sup>2-</sup>- and S<sup>2-</sup>-capped CdSe QDs. The obtained inorganic ligand-capped QDs, together with the initial oleylamine-capped QDs, were used as light-absorbing materials in the construction of quantum dot sensitized solar cells (QDSCs). Photovoltaic results indicate that thiosulfate-capped QDs give excellent power conversion efficiency (PCE) of 6.11% under the illumination of full one sun, which is remarkably higher than those of sulfide- (3.36%) and OAm-capped QDs (0.84%) and is comparable to the state-of-the-art value based on mercaptocarboxylic acid capped QDs. Photoluminescence (PL) decay characterization demonstrates that thiosulfate-based QDSCs have a much-faster electron injection rate from QD to TiO<sub>2</sub> substrate in comparison with those of sulfide- and OAm-based QDSCs. Electrochemical impedance spectroscopy (EIS) results indicate that higher charge-recombination resistance between potoanode and eletrolyte interfaces were observed in the thiosulfate-based cells. To the best of our knowledge, this is the first application of thiosulfate-capped QDs in the fabrication of efficient QDSCs. This will lend a new perspective to boosting the performance of QDSCs furthermore.
A packet prioritization scheme for 3D-HEVC content transmission over LTE networks (2015)

Long Term Evolution (LTE) has been standardized at the 3GPP since 2008 and targets the delivery of high data rate services with strict quality-of-service (QoS) requirements. It is now the fastest ever growing mobile technology and is gradually becoming the mainstream radio access technology used in cellular networks. The latest video coding standard, High Efficiency Video Coding (HEVC), achieves higher compression rate than its predecessor Advanced Video Coding (AVC) and for the same level of quality uses almost 50% less bandwidth. HEVC is the leading video compression technology that will be used to deliver high-definition (HD) and ultra-high-definition (UHD) video content to users. Extensions of HEVC, such as 3D-HEVC, are now being developed and standardized by MPEG to deliver 3D video content. The current issues with LTE include its lack of awareness regarding the type of packets being transmitted, and their importance to the end user. The aim of this paper is to investigate the performance of 3D-HEVC over LTE networks using metrics such as packet loss ratio and average user throughput. We also propose a cross-layer solution in the form of a packet prioritization scheme to help provide better quality-of-experience (QoE) to users and demonstrate its advantages over a baseline scheme that is not QoE-aware.
The Cotton-Insect Interactive Transcriptome – Molecular Elements Involved in Plant-Insect Interactions (2018)

The chewing insect boll weevil larvae (Anthonomus grandis) and phloem feeding insect Bemisia tabaci cause the loss of diverse cotton products. The pink cotton bollworm Pectinophora gossypiella is a model organism for insect responses to Bacillus thuringiensis (Bt) toxins, but the molecular mechanism of its tolerance was studied to a lesser extent. The increased quantity of secondary metabolites, namely, natural insecticides in plants is associated with abiotic stresses such as treatment with NaCl. The role of plants in mediating the interaction between herbivores and natural enemies of herbivores was demonstrated to be a critically dynamic phenomenon. To better control the insects, a subunit of mitochondrial complex I NDUFV2 that catalyzes NADH dehydrogenation in respiratory chain was suppressed by double-stranded RNA (dsRNA). The novel transcriptome approaches as vital applications in insect research should be very helpful to shed light on details of the molecular signatures and their interactions during insect-plant interaction.