gebhart/patrepeval huggingface dataset:
UWB antenna with notched band at 5.5 GHz (2013)

A slot antenna with a notched band at 5.5 GHz is proposed for UWB applications. The basic UWB antenna comprises of a rectangular radiating patch and a ground plane with a tapered shape slot and printed on 1.6 mm‐thick FR4 dielectric substrate. To realise a notch band, two symmetrical slits are etched on the slot of the ground plane. Experimental results show that the proposed antenna exhibits wideband performance from 3.08 to more than 11 GHz with a notched frequency band centred at 5.5 GHz which can effectively mitigate the interference between the WLAN and UWB systems. It is also confirmed from the measurements that the insertion of slits does not affect the antenna performance, except at the notched frequency band.
Feature Selection Framework for Multi-source Energy Harvesting Wireless Sensor Networks (2018)

International audience
Connexin40‐Deficient Mice Exhibit Atrioventricular Nodal and Infra‐Hisian Conduction Abnormalities (2000)

Cx40-deficient mice exhibit significant delay not only in infra-Hisian conduction, as would be expected from the expression of Cx40 in the His-Purkinje system but also in the electrophysiologic parameters that reflect AV nodal conduction. Our data suggest a significant role of Cx40 in atrionodal conduction and/or in proximal His-bundle conduction.
Fiberoptic evanescent wave infrared spectroscopy of gases in liquids (1995)

Silver halide optical fibers were used as attenuated total reflection elements for infrared evanescent wave spectroscopy of gases in liquids. The evanescent wave absorption spectra of chlorodifluoromethane (Freon-22) and carbon dioxide gases (CO2) in water were studied and the dependence on vapor pressure of the gas and temperature was investigated. Absorption peaks were easily traced and correlated well with those in the literature. The use of the infrared (IR) fibers in the fiberoptic evanescent wave spectroscopy system bypasses the difficulty of ordinary IR spectroscopy related to the strong IR absorption of most liquid solvents, and provides a flexible, easy, and inexpensive way of determining the presence and concentration of gases in liquids to within about 5% accuracy.
Supplementation of Conventional Therapy With the Novel Grain Salba (<i>Salvia hispanica L</i>.) Improves Major and Emerging Cardiovascular Risk Factors in Type 2 Diabetes (2007)

Long-term supplementation with Salba attenuated a major cardiovascular risk factor (SBP) and emerging factors (hs-CRP and vWF) safely beyond conventional therapy, while maintaining good glycemic and lipid control in people with well-controlled type 2 diabetes.
A porcine study of the area of heated tissue during hot‐balloon ablation: Implications for the clinical efficacy and safety (2020)

The hot-balloon set temperature, energy delivery time, and tissue temperature data obtained in this porcine study supported the clinical efficacy and safety of the hot-balloon ablation as currently practiced in patients with AF.
Tissue factor expression provokes escape from tumor dormancy and leads to genomic alterations (2020)

Our study shows that the clotting protein tissue factor (TF) controls the state of tumor dormancy and does so in conjunction with recruitment of inflammatory cells and blood vessels. We show that indolent glioma cells remain harmless in mice unless rendered TF positive. Our work also demonstrates the ability of TF to indirectly influence the DNA of cancer cells by facilitating gene mutations and silencing. This ability is important because injury, cardiovascular disease, or other conditions may activate the clotting system and contribute to the awakening of occult cancer cells. This understanding also may suggest a prophylactic use of blood thinners in cases where dormant cancer cells and clotting are suspected to coexist (e.g., after surgery).
Construction of anthropomorphic hybrid, dual-lattice voxel models for optimizing image quality and dose in radiography (2014)

In radiography there is generally a conflict between the best image quality and the lowest possible patient dose. A proven method of dosimetry is the simulation of radiation transport in virtual human models (i.e. phantoms). However, while the resolution of these voxel models is adequate for most dosimetric purposes, they cannot provide the required organ fine structures necessary for the assessment of the imaging quality. The aim of this work is to develop hybrid/dual-lattice voxel models (called also phantoms) as well as simulation methods by which patient dose and image quality for typical radiographic procedures can be determined. The results will provide a basis to investigate by means of simulations the relationships between patient dose and image quality for various imaging parameters and develop methods for their optimization. A hybrid model, based on NURBS (Non Linear Uniform Rational B-Spline) and PM (Polygon Mesh) surfaces, was constructed from an existing voxel model of a female patient. The organs of the hybrid model can be then scaled and deformed in a non-uniform way i.e. organ by organ; they can be, thus, adapted to patient characteristics without losing their anatomical realism. Furthermore, the left lobe of the lung was substituted by a high resolution lung voxel model, resulting in a dual-lattice geometry model. “Dual lattice” means in this context the combination of voxel models with different resolution. Monte Carlo simulations of radiographic imaging were performed with the code EGS4nrc, modified such as to perform dual lattice transport. Results are presented for a thorax examination.
Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses (2019)

The nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t (RORγt) is the key transcription factor required for Th17 cell differentiation and for production of IL-17 family cytokines by innate and adaptive immune cells. Dysregulated Th17 immune responses have been associated with the pathogenesis of several inflammatory and autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis. In this article, we describe the <i>in vitro</i> pharmacology of a potent and selective low molecular weight RORγt inhibitor identified after a structure-based hit-to-lead optimization effort. The compound interfered with co-activator binding to the RORγt ligand binding domain and impaired the transcriptional activity of RORγt as evidenced by blocked IL-17A secretion and RORE-mediated transactivation of a luciferase reporter gene. The inhibitor effectively reduced IL-17A production by human naive and memory T-cells and attenuated transcription of pro-inflammatory Th17 signature genes, such as <i>IL17F, IL22, IL26, IL23R</i>, and <i>CCR6</i>. The compound selectively suppressed the Th17/IL-17 pathway and did not interfere with polarization of other T helper cell lineages. Furthermore, the inhibitor was selective for RORγt and did not modify the transcriptional activity of the closely related family members RORα and RORβ. Using human keratinocytes cultured with supernatants from compound treated Th17 cells we showed that pharmacological inhibition of RORγt translated to suppressed IL-17-regulated gene expression in keratinocyte cell cultures. Furthermore, in <i>ex vivo</i> immersion skin cultures our RORγt inhibitor suppressed IL-17A production by Th17-skewed skin resident cells which correlated with reduced human β defensin 2 expression in the skin. Our data suggests that inhibiting RORγt transcriptional activity by a low molecular weight inhibitor may hold utility for the treatment of Th17/IL-17-mediated skin pathologies.
Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits. (1986)

Through the use of a quantitative solution hybridization assay with 32P-labeled cDNA probes, we found that mevinolin, an inhibitor of cholesterol synthesis, elevates the level of mRNA for the low density lipoprotein receptor in livers of hamsters and rabbits. In hamsters the maximal effect (3-fold increase) occurred at 0.1% mevinolin in the diet for 10 days. The same dose produced a maximal induction (10-fold) of mRNA levels for 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme of cholesterol synthesis, and a maximal decrease (80%) in plasma cholesterol. The drug lowered the level of all cholesterol-carrying lipoproteins in plasma. In normal rabbits, mevinolin produced a 90% reduction in plasma low density lipoprotein-cholesterol levels, which was associated with a 2.5-fold increase in low density lipoprotein receptor mRNA levels. A similar induction of receptor mRNA occurred in livers of Watanabe-heritable hyperlipidemic rabbits, although the plasma cholesterol was not reduced to normal, presumably because the receptors produced by the mutant mRNA function poorly. These data are consistent with the hypothesis that mevinolin and other inhibitors of 3-hydroxy-3-methylglutaryl CoA reductase lower plasma cholesterol levels in part by stimulating production of mRNA for the low density lipoprotein receptor in liver.
ChemInform Abstract: Reusable and Sustainable Nanostructured Skeleton Catalyst: Heck Reaction with Nanoporous Metallic Glass Pd (PdNPore) as a Support, Stabilizer and Ligand‐Free Catalyst. (2012)

Abstract PdNPore can be used in at least five runs without loss activity.
Micromachined inking chip for scanning probe nanolithography using local thermal vapor inking method (2006)

Here the authors show a method for inking scanning probes based on local thermal evaporative inking transfer. This method results in low loss, rapid, and parallel inking action. Scanning probes are accommodated at openings of ink reservoirs. A resistive heater is used to initiate vaporization of inks to uniformly coat probes. 1mM 16-mercaptohexadecanoic acid in ethanol solution is used to characterize this inking chip. Moreover, an array of scanning probes can be inked simultaneously using an array of inking reservoirs. During the inking process, each probe is tightly sealed inside individual reservoir so cross contamination is limited.
System and method for returning material from the Br.sub.2 side of an H.sub.2/Br.sub.2 flow battery back after crossover (2023)

A flow battery system includes a first tank having a hydrogen reactant, a second tank having a bromine electrolyte, at least one cell including a hydrogen reactant side operably connected to the first tank through an ¾ feed and return system and a bromine electrolyte side operably connected to the second tank, and a crossover return system. The crossover return system includes a vessel operably connected to the ¾ feed and return system and configured to receive an effluent containing a first portion of the hydrogen reactant and a second portion of the bromine electrolyte, the vessel configured to separate the first portion from the second portion. A first return line returns the first portion of the hydrogen reactant to the first tank and a second return line returns the bromine electrolyte to the second tank.
UNCERTAIN CHAOTIC SYSTEM CONTROL VIA ADAPTIVE NEURAL DESIGN (2002)

Though chaotic behaviors are exhibited in many simple nonlinear models, physical chaotic systems are much more complex and contain many types of uncertainties. This paper presents a robust adaptive neural control scheme for a class of uncertain chaotic systems in the disturbed strict-feedback form, with both unknown nonlinearities and uncertain disturbances. To cope with the two types of uncertainties, we combine backstepping methodology with adaptive neural design and nonlinear damping techniques. A smooth singularity-free adaptive neural controller is presented, where nonlinear damping terms are used to counteract the disturbances. The differentiability problem in controlling the disturbed strict-feedback system is solved without employing norm operation, which is usually used in robust control design. The proposed controllers can be applied to a large class of uncertain chaotic systems in practical situations. Simulation studies are conducted to verify the effectiveness of the scheme.
Evidence that anandamide‐signaling regulates human sperm functions required for fertilization (2002)

Ejaculated mammalian sperm require several hours exposure to secretions in female reproductive tracts, or incubation in appropriate culture medium in vitro, before acquiring the capacity to fertilize eggs. Arachidonylethanolamide (AEA), also known as anandamide, is a novel lipid-signal molecule that is an endogenous agonist (endocannabinoid) for cannabinoid receptors. We now report that AEA is present in human seminal plasma, mid-cycle oviductal fluid, and follicular fluid analyzed by high-performance liquid chromatography/mass spectrometry. Sperm are sequentially exposed to these reproductive fluids as they move from the vagina to the site of fertilization in the oviduct. Specific binding of the potent cannabinoid agonist [(3)H]CP-55,940 to human sperm was saturable (K(D) 9.71 +/- 1.04 nM), suggesting that they express cannabinoid receptors. R-methanandamide [AM-356], a potent and metabolically stable AEA analog, and (-)delta(9) tetrahydrocannabinol (THC), the major psychoactive constituent of Cannabis, modulated capacitation and fertilizing potential of human sperm in vitro. AM-356 elicited biphasic effects on the incidence of hyperactivated sperm motility (HA) between 1 and 6 hr of incubation: at (2.5 nM) it inhibited HA, while at (0.25 nM) it stimulated HA. Both AM-356 and THC inhibited morphological alterations over acrosomal caps between 2 and 6 hr (IC(50) 5.9 +/- 0.6 pM and 3.5 +/- 1.5 nM, respectively). Sperm fertilizing capacity, measured in the Hemizona Assay, was reduced 50% by (1 nM) AM-356. These findings suggest that AEA-signaling may regulate sperm functions required for fertilization in human reproductive tracts, and imply that smoking of marijuana could impact these processes. This study has potential medical and public policy ramifications because of the incidence of marijuana abuse by adults in our society, previously documented reproductive effects of marijuana, and the ongoing debate about medicinal use of marijuana and cannabinoids.
Supplementary Table 4 from Molecular Predictors of Sensitivity to the Insulin-like Growth Factor 1 Receptor Inhibitor Figitumumab (CP-751,871) (2023)

&lt;p&gt;PDF file - 23K, Summary of figitumumab potency in selected cell lines in vitro and tumor growth inhibition for cell lines growth as subcutaneous tumor xenografts.&lt;/p&gt;
FUN! Fast, Universal, Non-Semantic Speech Embeddings. (2020)

Learned speech representations can drastically improve performance on tasks with limited labeled data. However, due to their size and complexity, learned representations have limited utility in mobile settings where run-time performance is a significant bottleneck. We propose a class of lightweight universal speech embedding models based on MobileNet that are designed to run efficiently on mobile devices. These embeddings, which encapsulate speech non-semantics and thus can be re-used for several tasks, are trained via knowledge distillation. We show that these embedding models are fast enough to run in real-time on a variety of mobile devices and exhibit negligible performance degradation on most tasks in a recently published benchmark of non-semantic speech tasks. Furthermore, we demonstrate that these representations are useful for mobile health tasks such as mask detection during speech and non-speech human sounds detection.
Autonomous Raman Amplifiers Using Standard Integrated Network Equipment (2021)

Practical needs related to infrastructure management are driving optical network operators to include Raman amplification in order to improve the performance of long fiber spans. Compared to standard erbium-doped fiber amplifier (EDFA) management, Raman amplifiers require a greater degree of control and monitoring due to their distributed nature. Inevitably, this update leads to a key consideration; the introduction of additional telemetry devices with respect to standard EDFA photodiodes, resulting in an increase in required investments. In this work, we present an embedded controller architecture in combination with an ad-hoc probing procedure to manage Raman amplification within disaggregated optical networks, using only standard integrated equipment, allowing an efficient implementation without the introduction of optical channel monitors (OCMs). This proposal is validated using a fully representative experimental campaign, testing both the probing procedure on a single fiber span and the operation of a Raman amplifier using the extracted information.
Enabling Modular Robotics with Secure Transducer Identification Based on Extended IEEE 21450 Transducer Electronic Datasheets (2023)

In robotics, there are many different sensors and actuators mounted onto a robot which may also, in the case of modular robotics, be interchanged during operation. During development of new sensors or actuators, prototypes may also be mounted onto a robot to test functionality, where the new prototypes often have to be integrated manually into the robot environment. Proper, fast and secure identification of new sensor or actuator modules for the robot thus becomes important. In this work, a workflow to add new sensors or actuators to an existing robot environment while establishing trust in an automated manner using electronic datasheets has been developed. The new sensors or actuators are identified via near field communication (NFC) to the system and exchange security information via the same channel. By using electronic datasheets stored on the sensor or actuator, the device can be easily identified and trust can be established by using additional security information contained in the datasheet. In addition, the NFC hardware can simultaneously be used for wireless charging (WLC), thus allowing for wireless sensor and actuator modules. The developed workflow has been tested with prototype tactile sensors mounted onto a robotic gripper.
Probing fundamental physics with spin-based quantum sensors (2023)

The applications of spin-based quantum sensors to measurements probing fundamental physics are surveyed. Experimental methods and technologies developed for spin-based quantum information science have rapidly advanced in recent years and these tools enable increasingly precise control and measurement of spin dynamics. Theories of beyond-the-standard-model physics predict, for example, discrete-symmetry-violating electromagnetic moments correlated with particle spins, exotic spin-dependent forces, and coupling of spins to ultralight bosonic dark-matter fields. Spin-based quantum sensors can be used to search for these myriad phenomena and offer a methodology for tests of fundamental physics that is complementary to particle colliders and large-scale particle detectors. Areas of technological development that can significantly enhance the sensitivity of spin-based quantum sensors to new physics are highlighted.Received 30 January 2023DOI:https://doi.org/10.1103/PhysRevA.108.010101©2023 American Physical SocietyPhysics Subject Headings (PhySH)Research AreasAxionsOptical pumpingParticle dark matterQuantum measurementsQuantum metrologyTests of fundamental symmetriesZeeman effectAtomic, Molecular & OpticalParticles & FieldsQuantum Information
Abstract IA17: Pathway dependence and drug synergism in NF1-associated malignant peripheral nerve sheath tumors using the zebrafish model (2018)

Abstract Malignant peripheral nerve sheath tumors (MPNSTs) are very aggressive and often metastatic soft tissue sarcomas, which are frequently found in patients who have neurofibromatosis type 1 (NF1). Currently, surgical excision is the only curative therapy for MPNST; however, many patients have unresectable or metastatic tumors at diagnosis and the recurrence rate after surgery is high. Chemotherapy regimens are only partially effective and associated with significant toxicity that can severely reduce quality of life. To establish a preclinical model of this highly malignant tumor, we developed a faithful in vivo MPNST transplantation assay to assess pathway dependence. mCherry-labeled MPNSTs cells were harvested from nf1 and p53 mutant zebrafish and implanted into the pericardial space of embryos at 2 dpf. 24 hours later, we added multiple pathway inhibitors or DMSO vehicle to the fish water and the embryos were incubated for 4 days. Drugs in clinical use for MPNST were tested such as inhibitors of MEK (trametinib), RTK (sunitinib), mTOR (rapamycin), HSP90 (ganetespib), microtubules (vincristine), alkylating agents (cytoxan), XPO I (selinexor), topo II (etoposide), and topo I (topotecan). Of these, only topotecan and selinexor showed significant cytotoxic responses at their MTDs. These two inhibitors were also active in human MPNST cell lines, and we are testing to see if their tumor cell cytotoxic effects are synergistic. Clinical trials of Topo I and XPO I inhibitors have not been reported for MPNST, and our results indicate that these two drugs should be evaluated clinically in patients with this tumor. We are now assessing FDA-approved drugs to identify those that synergize with topotecan and selinexor to induce sustained MPNST cell death and improved survival at tolerable dosages. Our long-range goal is to define active combinations of three or more non-cross resistant drugs that exhibit synergistic and sustained tumor cell cytotoxicity at dosages tolerable to the host. Citation Format: Dong Hyuk Ki, Shuning He, A. Thomas Look. Pathway dependence and drug synergism in NF1-associated malignant peripheral nerve sheath tumors using the zebrafish model [abstract]. In: Proceedings of the AACR Conference on Advances in Sarcomas: From Basic Science to Clinical Translation; May 16-19, 2017; Philadelphia, PA. Philadelphia (PA): AACR; Clin Cancer Res 2018;24(2_Suppl):Abstract nr IA17.
LAYERED: Metric for Machine Translation Evaluation (2014)

This paper describes the LAYERED metric which is used for the shared WMT'14 metrics task. Various metrics exist for MT evaluation: BLEU In this paper, we propose an MT evaluation scheme that is based on the NLP layers: lexical, syntactic and semantic. We contend that higher layer metrics are after all needed. Results are presented on the corpora of ACL-WMT, 2013 and 2014. We end with a metric which is composed of weighted metrics at individual layers, which correlates very well with human judgment.
Isotermas de adsorción de bioplásticos de harina de yuca moldeados por compresión (2011)

Se evaluó la adsorción de agua y el calor isostérico de bioplásticos elabora- dos con harina de dos variedades de yuca (CM 7951-5 y MBRA 383), polvillo de fique y glicerol con la técnica de moldeo por compresión. Las isotermas de adsorción de las muestras poliméricas se realizaron a 15, 25, y 35°C en valores de actividad de agua que variaron entre 0.12 y 0.98, usando un mé- todo gravimétrico. Los valores experimentales de adsorción de agua fueron ajustados usando los modelos de GAB, Caurie, Oswin, Smith, Henderson y Peleg. El calor isostérico de adsorción (Qst) se determinó mediante la ecuación de Clausius-Clapeyron. Los resultados mostraron que el modelo de Peleg se ajustó adecuadamente a valores experimentales de adsorción a 15, 25 y 35°C en las muestras elaboradas con la variedad CM 7951-5 y a 15 y 25°C para la variedad MBRA 383, mientras que el modelo de GAB fue a 35°C para MBRA 383. El calor isostérico de sorción disminuyó con el incremento en el contenido de humedad de equilibrio alcanzándose un valor máximo de 87 Kj/mol y 78 Kj/mol y un mínimo de 44.6 Kj/mol y 44.5 Kj/mol en las muestras elaboradas con CM 7951-5 y MBRA 383 respectivamente.