gebhart/patrepeval huggingface dataset:
Amphiphilic 4-Helix Bundles Designed for Biomolecular Materials Applications (2005)

ADVERTISEMENT RETURN TO ISSUEPREVCorrectionAmphiphilic 4-Helix Bundles Designed for Biomolecular Materials ApplicationsShixin Ye, Joseph W. Strzalka, Bohdana M. Discher, Dror Noy, Songyan Zheng, P. Leslie Dutton, and J. Kent BlasieCite this: Langmuir 2006, 22, 1, 512Publication Date (Web):December 8, 2005Publication History Published online8 December 2005Published inissue 1 January 2006https://pubs.acs.org/doi/10.1021/la058024chttps://doi.org/10.1021/la058024ccorrectionACS PublicationsCopyright © 2006 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views267Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (15 KB) Get e-AlertscloseSUBJECTS:Biomaterials,Fluid dynamics,Monomers,Peptides and proteins,Solid phase synthesis Get e-Alerts
Fully-integrated high-order NMOS sampled-data ladder filters (1978)

This paper will disclose an approach for implementing NMOS sampled-data recursive filters by using switched-capacitor integrators in an active ladder configuration. Experimental results for a fifth order Chebyshev 3400Hz low-pass filter with 0.1dB passband ripple will be presented.
CsMnBr<sub>3</sub>: Lead-Free Nanocrystals with High Photoluminescence Quantum Yield and Picosecond Radiative Lifetime (2021)

Lead halide compounds, including lead halide perovskite nanocrystals (NCs), have attracted the interest of researchers in optoelectronics and photonics because of their high photoluminescence quantum yields (PLQYs) coupled with relatively short PL lifetimes (on the order of a few nanoseconds). However, lead-free metal halides of high PLQY, including double perovskites and their doped NCs, typically possess long PL lifetimes (up to microseconds) that limit their application space. Here, we introduce CsMnBr3 NCs, which are lead-free and red-emitting, that combine a high PLQY with an exceptionally short radiative lifetime (on the order of picoseconds). We find that the octahedral coordination of Mn2+ in CsMnBr3 induces a red emission centered at ∼643 nm with a PLQY of ∼54% and a fast radiative decay rate. Femtosecond transient absorption and transient PL spectroscopies reveal the existence of a low-lying excited state of Mn2+ that relaxes to the ground state within around 605 ps by emitting light at around 643 nm. At greater excitation energies, higher excited states of Mn2+ relax in the sub-nanosecond time scale to this low-lying excited state. A similarly positioned PL peak with a short picosecond scale PL lifetime and a PLQY of ∼6.7% was also detected in bulk CsMnBr3 single crystals reported in this study—a relatively high quantum yield for a bulk material. Our experimental results and density functional theory modelling show that the crystal structure and the strong coupling among Mn2+ ions govern those luminescence properties of CsMnBr3 NCs and single crystals. These findings pave the way for new lead-free materials that combine high PLQY and ultrafast luminescence.
691-P: Evaluation of an Implantable CGM System Using a Multiple-Analyte Indicator Hydrogel for Calibration Reduction (2022)

Background: The Eversense CGM System sensor is implanted in the upper arm. It uses a fluorescent, boronic acid glucose-binding moiety to measure glucose. The glucose indicator is susceptible to oxidative de-boronation from reactive oxygen species (ROS) in the interstitial fluid, necessitating daily calibrations. To reduce calibration frequency, a ROS indicator was added to measure oxidative de-boronation. Figure 1 (a) shows the copolymerization of glucose and ROS indicators into a single hydrogel matrix with orthogonal excitation emission properties. The sensor uses a 380 nm LED for excitation of the glucose indicator and a 470 nm LED for excitation of the ROS indicator. Methods: The fluorescence of the indicators was characterized in vitro. In addition, sensors were implanted in subjects with type 1 diabetes in a 365-day clinical feasibility study to assess accuracy against fingerstick measurements. Results: Figure 1 (b) illustrates the relationship whereby ROS exposure increases the fluorescence of the ROS indicator and decreases the fluorescence of the glucose indicator. A MARD of 9.9% against fingerstick with one calibration per week was observed through 90 days. Conclusions: Early data suggests the multiple-analyte system should allow the next generation of long-term, implanted CGM systems to maintain accuracy with significantly reduced calibration requirements. Disclosure V.N.Velvadapu: None. J.M.Masciotti: Employee; Senseonics. A.D.Dehennis: Employee; Senseonics. P.Sanchez: Employee; Senseonics. K.S.Tweden: Employee; Senseonics. F.R.Kaufman: Consultant; Twin Health, Employee; Senseonics. S.Ioacara: Research Support; Senseonics.
Chlorin e6‐embedded starch nanogels for improved photodynamic tumor ablation (2018)

In this study, we report on a polysaccharide‐based nanogel composed of starch conjugated with a photosensitizing chlorin e6 (Ce6) and hydrophilic poly (ethylene glycol) (PEG). The proposed design of the nanogel takes advantage of its hydrogel network and high oxygen‐carrying capacity originated by the water‐swollen and water‐holding characteristics of starch. This resulted in a decrease in the auto‐quenching effect and an increase in the photoactivity of Ce6 molecules inserted into starch. In addition, PEG decoration was introduced to enhance the colloidal stability of the nanogels. Our experimental results revealed that the nanogel structure of starch liked to Ce6 and PEG produced a significant level of singlet oxygen and elicited noticeable A549 tumor cell death under light irradiation, thereby suggesting their potential use in photodynamic tumor therapy.
Supplementary Figure 3 from Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci (2023)

&lt;p&gt;Supplementary Figure 3. Absolute Risk (A model with only family history of prostate cancer)&lt;/p&gt;
ChemInform Abstract: Model Studies Directed Toward Forskolin: 1,9‐Dideoxyforskolin from a Bicyclic Precursor. (1988)

Abstract On a series of reactions, carried out with the bicyclic labdane derivative (I), only the sequence shown in the scheme leads to the desired result, i.e. the construction of the silyl ether (VIa).
Quantitative Susceptibility Mapping in Cerebral Cavernous Malformations: Clinical Correlations (2016)

The study revealed a positive correlation between mean quantitative susceptibility mapping signal and patient age in cerebral cavernous malformation lesions, higher mean quantitative susceptibility mapping signal in hemorrhagic lesions, and minimum longitudinal quantitative susceptibility mapping signal change in clinically stable lesions. Quantitative susceptibility mapping has the potential to be a novel imaging biomarker supplementing conventional imaging in cerebral cavernous malformations. The clinical significance of such measures merits further study.
Evapotranspiration Measurements and Modeling (2022)

Evaporation is the conversion process of liquid water into vapor and the consequent transport of that vapor into the atmosphere [...]
Abstract TP106: Automated Assessment of Behavioral Function After Experimental Stroke (2020)

Introduction: Manual scoring of behavior tests is commonly used for assessing motor deficits after stroke, however, it is labor intensive and subject to bias. These limitations lead to inconsistent assessment between research groups and non-reproducible data. In this study, we investigated the feasibility of an automated motor deficit assessment system, Erasmus ladder, in two ischemic stroke models. Methods: Distal middle cerebral artery occlusion (dMCAO n=10) or transient middle cerebral artery occlusion (tMCAO 30 minutes, n=15) were performed on male C57BL6J mice (11-13 weeks) to generate cortical ischemic stroke, with. Naïve mice (n=10) were used as controls. Immunohistochemistry was performed on brains collected at post-stroke day (PD) 30 to assess for infarct size (MAP2) and inflammation (CD68). Mice without infarct in both cortex and striatum were excluded from the study. Behavior was assessed using Erasmus ladder at pre-stroke baseline (4 unperturbed and 4 perturbed sessions) and on PD 7, 14, 21, and 28 (all perturbed sessions). Results: Erasmus ladder detected significant motor deficits in the tMCAO model, specifically in the pre- and post- perturbed times as well as several key step types (HH long). Analyses in the tMCAO model reveal changes in various step patterns and their capability to react to the perturbation (obstacle). These significant motor deficits after tMCAO were detectable until PD28. We also observed a sustained decline in the use of affected limb compared to unaffected limb until PD28. While this trend is also present in dMCAO model, motor deficits were detected in the dMCAO only at early timepoints (PD7) and the difference subsided by PD28. Conclusion: We have assessed the data collected by Erasmus ladder on mice that underwent two commonly used stroke models (tMCAO and dMCAO). Our data showed that Erasmus ladder can detect long term motor deficit including reduced use of affected limb, step pattern, and motor reaction to obstacle. This automated instrument is effective in detecting motor deficits in the tMCAO model and thus, can be used to evaluate treatments for enhancing recovery after stroke.
Molecularly selective nanoporous membrane-based wearable organic electrochemical device for noninvasive cortisol sensing (2018)

Wearable biosensors have emerged as an alternative evolutionary development in the field of healthcare technology due to their potential to change conventional medical diagnostics and health monitoring. However, a number of critical technological challenges including selectivity, stability of (bio)recognition, efficient sample handling, invasiveness, and mechanical compliance to increase user comfort must still be overcome to successfully bring devices closer to commercial applications. We introduce the integration of an electrochemical transistor and a tailor-made synthetic and biomimetic polymeric membrane, which acts as a molecular memory layer facilitating the stable and selective molecular recognition of the human stress hormone cortisol. The sensor and a laser-patterned microcapillary channel array are integrated in a wearable sweat diagnostics platform, providing accurate sweat acquisition and precise sample delivery to the sensor interface. The integrated devices were successfully used with both ex situ methods using skin-like microfluidics and on human subjects with on-body real-sample analysis using a wearable sensor assembly.
Genome‐Wide Association of BMI in African Americans (2011)

Recent genome-wide association studies (GWAS) have identified multiple novel loci associated with obesity in Europeans but results in other ethnicities are less convincing. Here, we report a two-stage GWAS of BMI in African Americans. The GWAS was performed using the Affymetrix 6.0 platform in 816 nondiabetic and 899 diabetic nephropathy subjects. 746,626 single-nucleotide polymorphisms (SNPs) were tested for association with BMI after adjustment for age, gender, disease status, and population structure. Sixty high scoring SNPs that showed nominal association in both GWAS cohorts were further replicated in 3,274 additional subjects in four replication cohorts and a meta-analysis was computed. Meta-analysis of 4,989 subjects revealed five SNPs (rs6794092, rs268972, rs2033195, rs815611, and rs6088887) at four loci showing consistent associations in both GWAS (P < 0.0001) and replication cohorts (P < 0.05) with combined P values range from 2.4 × 10(-6) to 5 × 10(-5). These loci are located near PP13439-TMEM212, CDH12, MFAP3-GALNT10, and FER1L4 and had effect sizes between 0.091 and 0.167 s.d. unit (or 0.67-1.24 kg/m(2)) of BMI for each copy of the effect allele. Our findings suggest the presence of novel loci potentially associated with adiposity in African Americans. Further replication and meta-analysis in African Americans and other populations will shed light on the role of these loci in different ethnic populations.
A low-power low-noise CMOS charge-sensitive amplifier for capacitive detectors (2011)

In this paper, the design of a new low-power low-noise charge-sensitive amplifier (CSA) is presented. The proposed CSA is intended for capacitive sensor readout circuits such as interface circuits for solid-state detectors used in medical imaging and X-ray spectroscopy. A comprehensive noise analysis of readout systems that consist of a CSA followed by an RC-CR pulse shaper is presented. To facilitate predicting the noise behaviour of the system, the equivalent noise charge (ENC) equations are derived analytically. The readout circuit is designed and laid out in a 0.13-μm CMOS process. Post-layout simulations show that the conversion gain of the CSA with a 20 fF feedback capacitor is 37.5 mV/fC. The estimated ENC of the readout system is 38 e̅-rms at a 1 μs peaking time with a detector capacitance of 0.5 pF and a leakage current of 50 pA. The integral nonlinearity of the CSA is less than 0.74% for 0.5-3 ke̅. The open-loop gain of the amplifier is ~ 80 dB and the gain-bandwidth product is about 345 MHz. The CSA occupies 0.0021 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and consumes 37.5 μW from a 1.2 V supply.
Magnetic hyperthermia efficiency and<sup>1</sup>H-NMR relaxation properties of iron oxide/paclitaxel-loaded PLGA nanoparticles (2016)

Magnetic iron oxide nanoparticles (Fe-NPs) can be exploited in biomedicine as agents for magnetic fluid hyperthermia (MFH) treatments and as contrast enhancers in magnetic resonance imaging. New, oleate-covered, iron oxide particles have been prepared either by co-precipitation or thermal decomposition methods and incorporated into poly(lactic-co-glycolic acid) nanoparticles (PLGA-Fe-NPs) to improve their biocompatibility and in vivo stability. Moreover, the PLGA-Fe-NPs have been loaded with paclitaxel to pursue an MFH-triggered drug release. Remarkably, it has been found that the nanoparticle formulations are characterized by peculiar (1)H nuclear magnetic relaxation dispersion (NMRD) profiles that directly correlate with their heating potential when exposed to an alternating magnetic field. By prolonging the magnetic field exposure to 30 min, a significant drug release was observed for PLGA-Fe-NPs in the case of the larger-sized magnetic nanoparticles. Furthermore, the immobilization of lipophilic Fe-NPs in PLGA-NPs also made it possible to maintain Néel relaxation as the dominant relaxation contribution in the presence of large iron oxide cores (diameters of 15-20 nm), with the advantage of preserving their efficiency when they are entrapped in the intracellular environment. The results reported herein show that NMRD profiles are a useful tool for anticipating the heating capabilities of Fe-NPs designed for MFH applications.
Understanding complex magnetohydrodynamic activities associated with a relaxation in the HT-7 tokamak (2011)

A new relaxation instability with complex magnetohydrodynamics (MHD) activities is found in the HT-7 tokamak operational region, which manifests itself in bursts of hydrogen alpha-ray radiations, electron cyclotron emission and soft x-ray (SX) radiations on outer channels, as well as complex MHD perturbations, but without hard disruptions. The MHD modes are identified as m/n = 2/1, m/n = 3/2 and m/n = 5/3 just before the relaxation (m and n are poloidal and toroidal mode numbers, respectively). The Poincaré mapping, according to the measured perturbations of the MHD modes at the edge, is used to show the topology of magnetic field lines. It is found that a stochastic annular belt resulted just before the relaxation due to the m/n = 5/3 island overlapping with m/n = 2/1 and m/n = 3/2 islands. This qualitatively coincides with the results of SX tomography.
Influence of the RF Excitation of the Catalyst System on the Morphology of Multiwalled Carbon Nanotubes (2007)

Multiwalled carbon nanotubes were synthesized by catalytic chemical vapor deposition using two different methods of heating. By one method, an external resistive tube furnace was used, whereas the other method involved heating with radio frequency excitation by induction coil. A comprehensive comparison was made between these two methods with regards to feed gas utilization, nanotube growth efficiency, nanotube product characterization and morphology, and the formation of amorphous carbon and gaseous byproducts. The carbon nanotubes synthesized using radio frequency excitation exhibited smaller outer diameters, fewer carbon layers, less amorphous carbon, and superior crystalline properties than those produced by external tube furnace. The radio frequency process resulted in more rapid and sustained growth rates of the nanotubes and more efficient use of the carbon source. The reason for these enhanced effects by inductive heating may be due not only to the internally produced thermodynamic heat flow characteristics but perhaps also to induced electron currents generated within the magnetic and metallic catalytic clusters due to RF.
ChemInform Abstract: N‐(Trifluoroacetyl)‐α‐amino Acid Chlorides as Chiral Reagents for Friedel‐Crafts Synthesis. (1986)

Abstract Bei der Friedel‐Crafts‐Reaktion zwischen den Aromaten (I) und den N‐ Trifloracetyl x‐amino‐säurechloriden (II) bleibt die Stereochemie erhalten.
Degradation of neurodegenerative disease-associated TDP-43 aggregates and oligomers via a proteolysis-targeting chimera (2023)

Our study demonstrated the dual-targeting capacity of the newly-designed PROTAC 2 against both C-TDP-43 aggregates and oligomers to reduce their neurotoxicity, which shed light on the potential drug development for ALS as well as other neurodegenerative diseases.
Multisite Study for Genotyping of the Factor II (Prothrombin) G20210A Mutation by the Invader Assay (2001)

The factor II (prothrombin) G20210A mutation (PT20210) is a recognized genetic risk factor for increased plasma prothrombin and venous thrombosis that is present in 6–7% of thrombosis patients and 1–2% of healthy individuals (1)(2)(3). The first occurrence of deep venous thrombosis is increased 1.4- to 5.6-fold in individuals carrying at least one mutant allele compared with the incidence in individuals without this mutation (4)(5).

In this report, we describe the novel application of the Factor II Invader® assay for the genotyping of patient specimens for the prothrombin G20210A mutation. The Invader assay is a sensitive, homogeneous, DNA-probe-based system for quantitatively detecting specific mutations directly from genomic DNA (6)(7)(8) as described previously by Hessner et al. (9) and Ledford et al. (10)

To evaluate the suitability of the Invader assay for detection of the prothrombin mutation, peripheral blood specimens from 528 patients (from four different sites) were collected in EDTA or sodium citrate tubes and genotyped. The four participating sites were ( a ) the University of Wisconsin Hospital and Clinics Molecular Pathology Laboratory (Madison, WI), ( b ) the Blood Center of Southeastern Wisconsin (Milwaukee, WI), ( c ) the University of Miami, Department of Pathology (Miami, FL), and ( d ) the University of Rochester, Department of Pathology and Molecular Laboratory (Rochester, NY).

Genomic DNA was isolated from 50–300 μL of buffy coat or whole blood with the QIAamp® Blood Kit (QIAGEN, Inc.), the Epicentre MasterPureTM DNA Purification Kit (Epicentre, Inc.), or the Bio-Rad InstaGeneTM Whole Blood Kit (Bio-Rad, Inc.; Table 1⇓ ). DNA was quantified by the PicoGreen® Assay (Molecular Probes) or by measuring absorbance at 260 nm. The DNA concentrations of …
ChemInform Abstract: Structure‐Based Design of Potent, Amidine‐Derived Inhibitors of Factor Xa: Evaluation of Selectivity, Anticoagulant Activity, and Antithrombotic Activity. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
General Purpose Interactive Physico-Chemical Property Exploration (2007)

There have been many tools and methods developed to investigate structure-activity (SAR) and structure-property (SPR) relationships. Many of these tools are fully or almost fully automated and attempt to predict various properties of molecules. Even with these tools, there is still an urgent need to provide a simple and useful methodology so a consumer of these various models, such as a medicinal chemist or molecular modeler, can learn how various properties of small molecules relate to their structure. This paper describes a new viewing and navigation paradigm called the Spiral View, which can be used to facilitate the interpretation of structure-property relationships. Examples of how this tool proves useful in the human interpretation of these relationships are drawn from the fields of experimental toxicity, LogP, and biological activity data drawn from various sources.
Neuraminidase activity and syncytial formation in variants of parainfluenza 3 virus (1983)

By a sensitive fluorometric assay method, we could definitely demonstrate neuraminidase activity for two variants of parainfluenza 3 virus, M and SC, which were previously shown to have no detectable neuraminidase activity. The enzyme activities of these viruses were very similar to each other, showing a much lower catalytic rate, a much higher Km value, and a more acidic pH optimum than those of the virus variants of high neuraminidase activity, 910N, LT, and MR. M and SC viruses eluted from guinea pig erythrocytes very poorly, whereas 910N and LT viruses eluted readily. M virus required the aid of a bacterial neuraminidase for effective growth and plaque formation in MDBK cells, but the virus grew well and formed plaques in R66 and Vero cells without the enzyme. SC virus required no exogenous neuraminidase for growth in all of these cell types. Depending on cell type, SC virus induced slight to extensive syncytial formation which was greatly inhibited by exogenous neuraminidase. In contrast, M virus induced extensive syncytial formation in all these cells regardless of the presence or absence of exogenous neuraminidase, although development and disintegration of the syncytia were more or less retarded by the enzyme, especially in MDBK cells. These results indicate that M virus possesses highly potent inducibility of syncytial formation which is further fortified by being low in viral neuraminidase activity.