gebhart/patrepeval huggingface dataset:
Self assembled hydrophobic nanoclusters of poly(methyl methacrylate) embedded into polyvinyl alcohol based hydrophilic matrix: Preparation and water sorption study (2008)

Abstract Hydrophilic matrices containing nanosized clusters of hydrophilic moieties have demonstrated potential applications in biomedical field. A novel hydrogel containing nanosized domains (20–35 nm) of hydrophobic moieties of poly(methyl methacrylate) (PMMA) was prepared by grafting crosslinked poly(acrylic acid‐ co ‐methyl methacrylate) chains onto polyvinyl alcohol (PVA) backbone using an efficient redox system. The graft copolymerization process was investigated to observe the influence of gel components on the kinetic parameters of grafting such as rate of grafting ( R g ), grafting yield ( G y ) and grafting efficiency ( G e ). The prepared graft nanohydrogel was evaluated for its water sorption potential under varying chemical composition of the gel and changing pH, temperature, and ionic strength of the swelling bath. The swelling process was also examined mechanistically and diffusion constants ( D ) of water molecules through the swellable nanohydrogel were also evaluated. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2009
Introducing new technologies into today's cleanup arena (1991)

The introduction of new technologies into the environmental cleanup arena has proven to be time-consuming, expensive, and encumbered by many institutional, regulatory, and technical obstacles. Therefore, cleanup contractors and regulators have tended to rely on established, historically proven technologies even though more effective approaches are needed. This paper addresses some of the key issues facing industry and the federal agencies in their attempts to use new technologies to meet expanding environmental management needs. 13 refs.
Diffusion‐Influenced Reversible Trapping Problem in the Presence of an External Field (2006)

We investigate the field effect on the diffusion-influenced reversible trapping problem in one dimension. The exact Green function for a particle undergoing diffusive motion between two static reversible traps with a constant external field is obtained. From the Green function, we derive the various survival probabilities. Two types of trap distribution for the many-body problem are considered, the periodic and random distributions. The mean survival probability is obtained for the crossing-forbidden case for the two types of trap distribution. For the periodic distribution it decays exponentially. For the random trap distribution, similar to the irreversible case, there exists a critical field strength at which the long time asymptotic behavior undergoes a kinetic transition from the power law to exponential behaviors. The difference between equilibrium concentrations for the two types of trap distribution due to the fluctuation effect of trap concentration vanishes as the field strength increases.
Cutting Edge: Molecular Portrait of Human Autoimmune Disease (2002)

Autoimmune diseases affect 3-5% of the population, are mediated by the immune response to self-Ags, and are characterized by the site of tissue destruction. We compared expression levels of >4,000 genes in PBMC of control individuals before and after immunization to those of individuals with four distinct autoimmune diseases. The gene expression profile of the normal immune response exhibits coordinate changes in expression of genes with related functions over time. In contrast, each individual from all autoimmune diseases displays a similar gene expression profile unrelated to the pattern of the immunized group. To our surprise, genes with a distinct expression pattern in autoimmunity are not necessarily "immune response" genes, but are genes that encode proteins involved in apoptosis, cell cycle progression, cell differentiation, and cell migration.
Electrophysiological effect of volume load in isolated canine hearts (1989)

In isolated isovolumic ventricles and in in situ ventricles under nonsteady-state conditions, alterations in load have been shown to affect electrophysiological properties via contraction-excitation feedback. However, the effect of alterations in loading conditions on electrophysiological properties in normal ventricles under physiological loading conditions remains unknown. Furthermore, the arrhythmogenic significance of these load-induced electrophysiological changes is uncertain. We increased end-diastolic volume (27 +/- 4 ml vs. 51 +/- 6 ml) and assessed conduction, refractoriness, ventricular fibrillation thresholds (VFTs), and inducibility of ventricular arrhythmias in 14 isolated blood-perfused ejecting canine ventricles under steady-state conditions. We also examined the effect of increased end-diastolic volume on refractoriness and monophasic action potential (MAP) duration and contour under isovolumic versus ejecting conditions. Under ejecting conditions, increased end-diastolic volume resulted in very small (less than 1.5%) changes in the absolute refractory period (10 mA) and in local activation time but no change in local electrogram duration, overall dispersion of refractoriness, MAP duration or contour, VFT, or inducibility of ventricular arrhythmias. Increased volume loading under isovolumic conditions resulted in a very slight (less than 1%) shortening of MAP duration and refractoriness but had no effect on the MAP contour. These findings provide strong evidence that alterations in volume load are of little electrophysiological or arrhythmogenic importance in normal canine ventricles under physiologically loaded conditions (contraction-excitation feedback, load and arrhythmias, volume load).
Chirality-mediated bistability and strong frequency downshifting of the gyrotropic resonance of a magnetic vortex due to dynamic destiffening (2017)

The gyrotropic resonance frequency of a magnetic vortex, widely studied for applications in data storage and radio-frequency signal processing, increases with the vortex core's stiffness. In traditional disk-shaped elements, this stiffness increases if the core is shifted towards the element's edges. Here, the authors show that introducing a flat edge into a disk locally de-stiffens the core, resulting in the resonant frequency strongly decreasing when the core approaches the element's flat edge. By controllably displacing the core within the disk one can thus both increase or decrease the core's resonant frequency with respect to its value when unshifted. This has the effect of more than doubling the accessible range of resonant frequencies. However, more fundamentally, the above properties lead to a chirality-mediated bistability: for a given finite static in-plane magnetic field, one of two values of gyrotropic frequencies can be observed depending on the vortex chirality.
Vascular Endoscopy for Intravascular Surgery —An Experimental Study— (1992)

A combination of endoscope and high-pressure saline irrigation system was tested in the occlusion of experimental aneurysms, and angioplasty and fibrinolysis of vascular occlusive lesions in canine femoral arteries. Endoscopy provided detailed information about the aneurysmal orifice and lumen and aided balloon placement and detachment. Endoscopy visualized the dynamic changes accompanying thrombolysis and the fine intimal injury due to angioplasty invisible on angiography. Vascular endoscopy is valuable for pre-, intra-, and postoperative evaluation of intravascular interventions.
Internet Mapping: From Art to Science (2009)

We are designing, implementing, deploying, and operating a secure measurement platform capable of performing various types of Internet infrastructure measurements and assessments. We integrate state-of-the-art measurement and analysis capabilities to try to build a coherent view of Internet topology. In September 2007 we began to use this novel architecture to support ongoing global Internet topology measurement and mapping, and are now gathering the largest set of IP topology data for use by academic researchers. We are using the best available techniques for IP topology mapping, and are developing some new techniques, as well as supporting software for data analysis, topology generation, and interactive visualization of resulting large annotated graphs. This paper presents our current results, next steps, and future goals.
Network Meta-analysis in Mental Health Research (2017)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Psychiatry HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Psychiatry journal
Disgust and the insula: fMRI responses to pictures of mutilation and contamination (2004)

Although previous functional brain imaging studies have found that the insula responds selectively to facial expressions of disgust, it remains unclear whether the insula responds selectively to disgust-inducing pictures. In this fMRI study, healthy volunteers viewed pictures of contamination, human mutilation, attacks and neutral scenes during scanning, and then rated pictures for the 'basic' emotions. The anterior insula responded to contamination and mutilation but not attacks, while the ventral visual areas responded to attacks and mutilations more strongly than contamination. The above activations were predicted by disgust and arousal ratings respectively. Additionally, mutilations uniquely activated the right superior parietal cortex. These results support selective disgust processing at the insula, and suggest distinct neural responses to contamination and mutilation.
Effects of Aggregate Surface and Water on Rheology of Asphalt Films (2007)

Most tests used to evaluate moisture damage require compacted asphalt mixtures. The tests generally simulate field material and conditions and provide a performance-related parameter of moisture effects. In mixtures, however, variable asphalt-aggregate-air void structure contributes to the difficulty of isolating the fundamental rheological properties of an asphalt-aggregate bond. To avoid the complications and obtain the properties of the asphalt-aggregate interface, a new experimental design was developed in this study. This test features a dynamic shear rheometer (DSR) as an improved tool for evaluating interface properties. One key feature of the experimental design is the use of rock disks to simulate an asphalt-aggregate interface. The simulated interface is easily wet-conditioned in a water cup installed on the DSR. From various testing protocols, a stress sweep test that defines a linear viscoelastic (LVE) region is adopted to evaluate the interaction and moisture effects of selected specimens. A viscoelastic characteristic produced from stress sweep tests is recommended as the fundamental property of the interaction and can be used to evaluate moisture effects onto the rheological behavior. One of the critical findings is that the LVE complex modulus, G * , measured at relatively small strains or stresses cannot evaluate the moisture effects on the bond of the asphalt-aggregate interface. The LVE G * measured at high shear stresses are instead much more effective at evaluating such moisture effects. Therefore, the results indicate that the role of moisture damage in pavement problems such as rutting or fatigue needs to be evaluated at design stresses covering a nonlinear viscoelastic range. This study focuses on understanding more the basic characteristics of asphalt-aggregate interface than the bulk properties of mixtures.
Are You Really Muted?: A Privacy Analysis of Mute Buttons in Video Conferencing Apps (2022)

Video conferencing apps (VCAs) make it possible for previously private spaces -- bedrooms, living rooms, and kitchens -- into semi-public extensions of the office. For the most part, users have accepted these apps in their personal space without much thought about the permission models that govern the use of their private data during meetings. While access to a device's video camera is carefully controlled, little has been done to ensure the same level of privacy for accessing the microphone. In this work, we ask the question: what happens to the microphone data when a user clicks the mute button in a VCA? We first conduct a user study to analyze users' understanding of the permission model of the mute button. Then, using runtime binary analysis tools, we trace raw audio flow in many popular VCAs as it traverses the app from the audio driver to the network. We find fragmented policies for dealing with microphone data among VCAs -- some continuously monitor the microphone input during mute, and others do so periodically. One app transmits statistics of the audio to its telemetry servers while the app is muted. Using network traffic that we intercept en route to the telemetry server, we implement a proof-of-concept background activity classifier and demonstrate the feasibility of inferring the ongoing background activity during a meeting -- cooking, cleaning, typing, etc. We achieved 81.9% macro accuracy on identifying six common background activities using intercepted outgoing telemetry packets when a user is muted.
Safety and efficacy of an engineered hepatotropic AAV gene therapy for ornithine transcarbamylase deficiency in cynomolgus monkeys (2021)

X-linked inherited ornithine transcarbamylase deficiency (OTCD) is the most common disorder affecting the liver-based urea cycle, a pathway enabling detoxification of nitrogen waste and endogenous arginine biosynthesis. Patients develop acute hyperammonemia leading to neurological sequelae or death despite the best-accepted therapy based on ammonia scavengers and protein-restricted diet. Liver transplantation is curative but associated with procedure-related complications and lifelong immunosuppression. Adeno-associated viral (AAV) vectors have demonstrated safety and clinical benefits in a rapidly growing number of clinical trials for inherited metabolic liver diseases. Engineered AAV capsids have shown promising enhanced liver tropism. Here, we conducted a good-laboratory practice-compliant investigational new drug-enabling study to assess the safety of intravenous liver-tropic AAVLK03 gene transfer of a human codon-optimized <i>OTC</i> gene. Juvenile cynomolgus monkeys received vehicle and a low and high dose of vector (2 × 10<sup>12</sup> and 2 × 10<sup>13</sup> vector genome (vg)/kg, respectively) and were monitored for 26 weeks for in-life safety with sequential liver biopsies at 1 and 13 weeks post-vector administration. Upon completion of monitoring, animals were euthanized to study vector biodistribution, immune responses, and histopathology. The product was well tolerated with no adverse clinical events, predominant hepatic biodistribution, and sustained supra-physiological OTC overexpression. This study supports the clinical deployment of intravenous AAVLK03 for severe OTCD.
Nonlinear control of hydraulic robots (2001)

This paper addresses the control problem of hydraulic robot manipulators. The backstepping design methodology is adopted to develop a novel nonlinear position tracking controller. The tracking errors are shown to be exponentially stable under the proposed control law. The controller is further augmented with adaptation laws to compensate for parametric uncertainties in the system dynamics. Acceleration feedback is avoided by using two new adaptive and robust sliding-type observers. The adaptive controllers are proven to be asymptotically stable via Lyapunov analysis. Simulation and experimental results performed with a hydraulic Stewart platform demonstrate the effectiveness of the approach.
The Blue Move for a Green Economy : Behovsstudie och teknikkartläggning av arbetsmaskiner (2018)

The Blue Move project aims to generate an increased demand for hydrogen as a fuel and investigate the business potential of heavy machinery in the Öresund-Kattegatt- Skagerrak (ÖKS) region, contributing for renewable energy in the transport sector to increase. The use of heavy machinery generates significant carbon dioxide emissions and local air pollution. By using machines with batteries and/or fuel cells instead of combustion engines, local air pollution and climate impact from the machines can be reduced. Electrification also reduces noise and vibration problems, contributing to an improved local and working environment. Customers' requirements are changing and within the near future some clients will only buy zero-emission vehicles. For example, many municipalities have high environmental targets and aim to be climate neutral and fossil fuel-free by 2030. Setting the requirements for public procurement, municipalities and regions become very important players in the process of converting to fossil fuel-free working machines. Electrification is on the rise and the development is fast, which, in addition to the environmental benefits, allows many benefits such as increased service life and a reduced number of components. The cost and character of the service of the vehicles will also change. The choice between electrical operation with batteries or with fuel cells depends on the cost, weight and space requirement for the current energy need. When operating on fuel cells, the heavy machinery can be quickly fueled, and it has an unchanged performance from full to empty tank. The use of fuel cells is also space-saving compared with fullelectric machines since areas for charging or battery change are not required. Today there are both battery and fuel cell - electric heavy machinery available on the market. This report gives an overview of available equipment, but also prototype and demo machines. Both a continued technical development and an increased market share for emission-free vehicles are required to meet future environmental goals. In order to achieve success, it is important that customers and manufacturers meet.
Secondary Phase and Mechanism of Enzymic Milk Coagulation (1975)

Immobilized enzymes were used as tools to study the secondary phase apart from the enzymic phase of milk coagulation. Skim milk, after passing through a column of pepsin or rennet bound to porous glass, was subjected to changes in pH, temperature, and dilution, and their effects on rate of coagulation were studied. The secondary phase exhibited a high temperature coefficient (Q10) of 11 to 12 between 20 C and 50 C and a 30-fold decrease in eoagulatiort time when the pt! of the secondary phase was lowered from 6.7 to 5.6. When fresh sklmmilk was added in increasing amounts to the treated effluent skim milk prior to assay, the entire mix.re coagulated with proportionally longer coagulation times indicating that r~ot all of the x-casein need be enzymically attacked for coagulation but only enough to initiate aggregation of micelles. TREATED MtLY, FLUIDIZED BED ~" ~"~ ~,cTo~ ~ ~i
Are molecular tools clarifying or confusing our understanding of the public health threat from zoonotic enteric protozoa in wildlife? (2019)

Emerging infectious diseases are frequently zoonotic, often originating in wildlife, but enteric protozoa are considered relatively minor contributors. Opinions regarding whether pathogenic enteric protozoa may be transmitted between wildlife and humans have been shaped by our investigation tools, and have led to oscillations regarding whether particular species are zoonotic or have host-adapted life cycles. When the only approach for identifying enteric protozoa was morphology, it was assumed that many enteric protozoa colonized multiple hosts and were probably zoonotic. When molecular tools revealed genetic differences in morphologically identical species colonizing humans and other animals, host specificity seemed more likely. Parasites from animals found to be genetically identical - at the few genes investigated - to morphologically indistinguishable parasites from human hosts, were described as having zoonotic potential. More discriminatory molecular tools have now sub-divided some protozoa again. Meanwhile, some infection events indicate that, circumstances permitting, some "host-specific" protozoa, can actually infect various hosts. These repeated changes in our understanding are linked intrinsically to the investigative tools available. Here we review how molecular tools have assisted, or sometimes confused, our understanding of the public health threat from nine enteric protozoa and example wildlife hosts (<i>Balantoides coli</i> - wild boar; <i>Blastocystis</i> sp. - wild rodents; <i>Cryptosporidium</i> spp. - wild fish; <i>Encephalitozoon</i> spp. - wild birds; <i>Entamoeba</i> spp. - non-human primates; <i>Enterocytozoon bieneusi</i> - wild cervids; <i>Giardia duodenalis</i> - red foxes; <i>Sarcocystis nesbitti</i> - snakes; <i>Toxoplasma gondii</i> - bobcats). Molecular tools have provided evidence that some enteric protozoa in wildlife may infect humans, but due to limited discriminatory power, often only the zoonotic potential of the parasite is indicated. Molecular analyses, which should be as discriminatory as possible, are one, but not the only, component of the toolbox for investigating potential public health impacts from pathogenic enteric protozoa in wildlife.
First experience with heterotopic thoracic pig-to-baboon cardiac xenotransplantation (2010)

This is the first description of a heterotopic thoracic pig-to-baboon heart transplantation. The procedure combines the advantages of a working heart model with the safety of heterotopic transplantation. In contrast to orthotopic transplantation, the recipient heart can assist the donor heart during episodes of rejection. We believe that the heterotopic thoracic model may accelerate the progress into the clinical application of cardiac xenotransplantation. However, successful combination of this heterotopic transplantation with an experimental model of cardiac failure may be needed before this technique can be promoted to clinical trials.
A simple strategy to generate small deletions using<i>Bal</i>31 nuclease (1990)

Journal Article A simple strategy to generate small deletions using Bal31 nuclease Get access Vitalia Henriquez, Vitalia Henriquez Public Health Research Institute455 First Avenue, New York, NY 10016, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Maria Laura Gennaro Maria Laura Gennaro * Public Health Research Institute455 First Avenue, New York, NY 10016, USA *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Nucleic Acids Research, Volume 18, Issue 22, 25 November 1990, Pages 6735–6736, https://doi.org/10.1093/nar/18.22.6735 Published: 25 November 1990 Article history Received: 09 October 1990 Published: 25 November 1990