gebhart/patrepeval huggingface dataset:
Impact of the Big Crew Change on Employee Retention (2014)

Talent &amp; Technology You have invested a lot of time and money training new employees. Once employees are fully qualified, how do you retain them? The SPE Talent Council survey on factors affecting employee attraction and retention provides valuable insights. Documented in paper SPE 168112, the survey received responses from 1,737 people, and the results indicated that for those surveyed there are many important ways in which younger employees differ from older ones and that key retention factors differ with age. Survey respondents were asked to rate 31 factors for staying with an employer and 31 factors for leaving an employer on a 6-choice scale that ranged from “most important” to “not at all important” and “not applicable.” Only people who reported having more than one employer were asked questions about leaving. Most of the survey respondents had worked for multiple employers (Fig. 1). Once people have experience switching employers, it may take less provocation or less enticement to persuade them to make another change. For survey respondents, “golden handcuffs” were not very effective. “To qualify for a future benefit such as a pension or retiree medical coverage” ranked 15th out of 31 factors for staying for men over the age of 40, 22nd for women over age 40, and 26th for men and women under age 40. Opportunity’s Siren Call Opportunity was clearly the number one driver, but the results indicated the intensity of that driving force varies with age and gender. When people were asked to rate factors for leaving an employer, 53% of women and 49% of men under the age of 40 identified “insufficient opportunity, challenge, career potential” as “most important,” in comparison with 35% of women and 29% of men over the age of 40. When the question was worded “Why do you stay with an employer?” 53% of both men and women under age 40 identified “opportunity, challenge, career potential” as “most important,” in comparison with 39% of women and 32% of men over age 40. Opportunity, while clearly of paramount importance, was only part of the answer. The top factor captures 7% to 8% of the “most important” responses for why survey respondents stayed, and 10% to 12% for why they left (Fig. 2). Capture of 50% of the “most important” responses for why survey respondents leave requires seven to eight factors. Capture of 80% of the “most important” responses for why people leave takes 15 to 16 factors. The results of this survey indicated that for companies to have attrition rates below 20% requires attention to many factors.
Microchip laser–pumped continuous-wave doubly resonant optical parametric oscillator (1998)

We report what we believe to be the first use of a multilongitudinal-mode frequency-doubled microchip laser to pump a doubly resonant optical parametric oscillator (OPO). This compact OPO is based on potassium titanyl phosphate (KTP) and operates with a low pump power threshold of 35 mW. The OPO output consists of a single pair of signal and idler modes even though it is pumped with a multilongitudinal-mode pump laser. We achieved smooth tuning (1.7 GHz) of the output frequencies by temperature tuning of the pump laser.
Fate of Tableted Freeze-Dried siRNA Lipoplexes in Gastrointestinal Environment (2021)

The incorporation of siRNA into nanocarriers is mandatory to facilitate its intracellular delivery, as siRNA itself cannot enter cells. However, the incorporation of these nanocarriers into oral, solid dosage forms and their fate in the gastrointestinal environment is yet to be explored. In the present work, the fate of, (i) naked siRNA, (ii) freshly prepared siRNA lipoplexes, and (iii) tableted siRNA lipoplexes, in simulated gastric and intestinal fluids was studied. The siRNA, either released from or protected within the lipoplexes, was quantified by gel electrophoresis and siRNA efficacy was assessed in cell transfection. The freshly prepared lipoplexes kept their siRNA load and transfection efficiency totally preserved during 1 h of incubation in simulated gastric fluid at 37 °C. However, in simulated intestinal fluid, despite no release of siRNA from lipoplexes after 6 h of incubation, gene silencing efficacy was dramatically decreased even after 1 h of exposure. The lipoplexes obtained from tablets efficiently protected siRNA in simulated gastric fluid, thus preserving the gene silencing efficacy, whereas their incubation in simulated intestinal fluid resulted in a marked siRNA release and decreased gene silencing efficacy. These results provided a detailed explanation for understanding the fate of siRNA in gastrointestinal conditions, when simply loaded in lipoplexes or formulated in the form of tablets.
Temperature tuning of ultra-high Q/V SOI microcavities (2008)

Ultrahigh Q/V lineic silicon Fabry Perot (FP) microcavities relying on silica substrate have been fabricated. Two cavities designs are studied based respectively on cavity mode losses recycling and on mirrors with tapered sections. The experimental evolution of cavities characteristics are studied as a function of sample temperature. The authors achieve a quality factor of 58000 for a modal volume of 0.6 (&lambda;/n)<sup>3</sup>.
Shape and surface effects on the cytotoxicity of nanoparticles: Gold nanospheres versus gold nanostars (2015)

Gold nanoparticles are materials with unique optical properties that have made them very attractive for numerous biomedical applications. With the increasing discovery of techniques to synthesize novel nanoparticles such as star-shaped gold nanoparticles for biomedical applications, the safety and performance of these new nanomaterials must be systematically assessed before use. In this study, gold nanostars (AuNSTs) with multibranched surface structures were synthesized, and their influence on the cytotoxicity of human skin fibroblasts and rat fat pad endothelial cells (RFPECs) were assessed and compared with that of gold nanospheres (AuNSPs) with unbranched surfaces. Results showed that the AuNSPs with diameters of approximately 61.46 nm showed greater toxicity with fibroblast cells and RFPECs compared with the synthesized AuNSTs with diameters of approximately 33.69 nm. The AuNSPs were lethal at concentrations of 40 μg/mL for both cell lines, whereas the AuNSTs were less toxic at higher concentrations (400 μg/mL). The calculated IC50 (50% inhibitory concentration) values of the AuNSPs exposed to fibroblast cells were greater at 1 and 4 days of culture (26.4 and 27.7 μg/mL, respectively) compared with the RFPECs (13.6 and 13.8 μg/mL, respectively), indicating that the AuNSPs have a greater toxicity to endothelial cells. It was proposed that possible factors that could be promoting the reduced toxicity effects of the AuNSTs to fibroblast cells and RFPECs, compared with the AuNSPs may be size, surface chemistry, and shape of the gold nanoparticles. The reduced cell toxicity observed with the AuNSTs suggests that AuNSTs may be a promising material for use in biomedical applications.
Eicosanoids and the Regulation of Cardiac Glucose Transport (2002)

Intact actin microfilaments are necessary for insulin-regulated GLUT4 translocation from intracellular pools to the plasma membrane. Products of the lipoxygenase (LO) pathway were shown to be implicated in the regulation of actin cytoskeleton rearrangement. The aim of this study was to examine the role of these LO products for cardiac insulin signaling and glucose uptake, GLUT4 translocation, and actin-based cytoskeleton structure. Exposure of cardiomyocytes to esculetin or NDGA, two structurally different LO inhibitors, induced a complete inhibition of insulin-stimulated glucose uptake, whereas control cells showed a threefold stimulation by insulin. Addition of 12(S)-HETE rendered the NDGA-treated cells insulin-sensitive. Early insulin signaling was not changed in cells exposed to LO inhibitors. Cell surface biotinylation of control cells showed a twofold increase of GLUT4 at the cell surface after insulin stimulation. In contrast, the LO inhibitors induced a complete inhibition of insulin-stimulated GLUT4 translocation. Labeling of the F-actin cytoskeleton revealed a prominent disassembly of actin fibers in cells exposed to the LO inhibitors. In conclusion, we show here that products of the LO reaction participate in the organization of the actin network in ventricular cardiomyocytes. Inhibition of LO blocks GLUT4 translocation without affecting insulin signaling events. These data suggest that products of the LO reaction participate in the regulation of glucose transport by contribution to a rearrangement of actin cytoskeletal elements.
Morin Prevents Granule Cell Dispersion and Neurotoxicity <i>via</i> Suppression of mTORC1 in a Kainic Acid-induced Seizure Model (2018)

An abnormal reorganization of the dentate gyrus and neurotoxic events are important phenotypes in the hippocampus of patients with temporal lobe epilepsy (TLE). The effects of morin, a bioflavonoid constituent of many herbs and fruits, on epileptic seizures have not yet been elucidated, though its beneficial effects, such as its anti-inflammatory and neuroprotective properties, are well-described in various neurodegenerative diseases. In the present study, we investigated whether treatment with morin hydrate (MH) can reduce the susceptibility to seizures, granule cell dispersion (GCD), mammalian target of rapamycin complex 1 (mTORC1) activity, and the increases in the levels of apoptotic molecules and inflammatory cytokines in the kainic acid (KA)-induced seizure mouse model. Our results showed that oral administration of MH could reduce susceptibility to seizures and lead to the inhibition of GCD and mTORC1 activity in the KA-treated hippocampus. Moreover, treatment with MH significantly reduced the increased levels of apoptotic signaling molecules and pro-inflammatory mediators in the KA-treated hippocampus compared with control mice, suggesting a neuroprotective role. Therefore, these results suggest that morin has a therapeutic potential against epilepsy through its abilities to inhibit GCD and neurotoxic events in the <i>in vivo</i> hippocampus.
Reply to Özdemir, “Measles-Mumps-Rubella Vaccine and COVID-19 Relationship” (2020)

First, we thank Dr. Özdemir for having enough interest in our paper (1) to submit the Letter to the Editor. As an Opinion/Hypothesis paper, the very nature of the publication is to spark debate or counterarguments. Our recently funded clinical trial (Parsemus Foundation and Fast Grant, Emergent Ventures at the Mercatus Center, George Mason University) and primate studies (Fast Grant) are still in preliminary stages; therefore, we do not yet have data and associated statistical analyses to support the hypothesis that can be used to fully respond to the points made by Dr. Özdemir. Since our publication, however, additional anecdotal/circumstantial evidence supporting the hypothesis has accumulated with very little negative evidence. This includes information passed on to us by individuals with personal experiences or knowledge otherwise (i.e., military information, refugee camps, countries with recent measles-mumps-rubella [MMR] vaccination campaigns for adults) or via prepublications. But to address the specific points made, we offer the following.
Broadband 2  ×  2 multimode interference coupler for mid-infrared wavelengths (2021)

Beam splitters are core components of photonic integrated circuits and are often implemented with multimode interference couplers. While these devices offer high performance, their operational bandwidth is still restrictive for sensing applications in the mid-infrared wavelength range. Here we experimentally demonstrate a subwavelength-structured 2×2 multimode interference coupler with high performance in the 3.1-3.7µ<i>m</i> range, doubling the bandwidth of a conventional device.
Theoretical comparison and optimization of cadmium telluride and gallium arsenide photon-counting detectors for contrast-enhanced spectral mammography (2023)

GaAs is a promising detector material for contrast-enhanced spectral mammography that offers better spectral performance than CdTe.
The secretion of glucagon by transformed yeast strains (1987)

Saccharomyces cerevisiae strains were transformed with plasmids coding for modified mating factor alpha 1 leader sequences followed by glucagon. Glucagon-containing peptides which were secreted into the fermentation broth were isolated and their amino acid sequences determined. The yeast strain transformed with the sequence coding for the complete mating factor alpha 1 leader sequence preceding the glucagon gene (MT556) secreted glucagon plus glucagon extended at its N-terminal by parts of the leader sequence. The yeast strain transformed with the sequence coding for a truncated mating factor alpha 1 leader sequence before the glucagon gene (MT615) secreted glucagon. These observations suggest that S. cerevisiae is a suitable vehicle for the efficient expression of plasmids coding for polypeptides similar to glucagon (e.g. VIP, secretin, GIP).
Spectral properties of laser solitons in coupled semiconductor resonators (2011)

We report on the multistable emission frequency of laser solitons and show that independent laser solitons are not mutually coherent while the peaks of a cluster have a well established mutual phase relationship.
Abstract 1129: EGFR-mediated activation of RET in ASCL1+ lung adenocarcinoma (2016)

Abstract Lung cancer accounts for about 27% of the cancer related deaths in the USA annually. Pathologically, it is a very complex disease broadly classified into small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC). NSCLCs are further classified into squamous cell carcinoma, large cell carcinoma and adenocarcinoma. Achaete-scute homolog 1 (ASCL1), an important transcription factor essential in the development of neuroendocrine cells (NE) in lungs is shown to be specifically expressed in lung NE cancers and 10-20% of adenocarcinomas (AD) with NE differentiation (NED), thus suggesting a role in the pathogenesis of these tumors. Our previous study showed that ASCL1 is a regulator of the RET oncogene in AD with NED. RET is a receptor tyrosine kinase with two isoforms in humans: RET9 (short) and RET51 (long). We performed survival analysis to study implications of RET isoforms in ASCL1+ tumors and found that elevated expression of the long RET mRNA was associated with poor survival. Subsequent in vitro experiments demonstrated that treatment with EGF robustly induced phosphorylation of RET in HCC1833 and H1755 cell lines which have high endogenous levels of ASCL1 and RET but not in VMRC-LCD cell line which has high level of ASCL1 but low level of RET. EGF induced phosphorylation of RET was diminished by gefitinib and by EGFR siRNA. Immunoprecipitation results indicated direct binding between EGFR and RET in presence of EGF. Furthermore, a high throughput drug screening found 8 EGFR inhibitors that were 10 - 250 fold more cytotoxic in ASCL1+ compared with ASCL1- AD cells. These results implicate EGFR as a key regulator of RET activation in ASCL1+ AD and suggest that EGFR inhibitors may be therapeutic for this population of patients. Citation Format: Kaustubh N. Bhinge, Yang Lin, Hamed Rahi, Marie Christine Aubry, Aaron Mansfield, Irina Kovtun, Stephen Murphy, Ping Yang, Dennis Wigle, Joanne (Eunhee) Yi, Aqsa Nasir, Simone Terra, Julian Molina, George Vasmatzis, Farhad Kosari. EGFR-mediated activation of RET in ASCL1+ lung adenocarcinoma. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 1129.
Muscarinic acetylcholine receptor knockout mice show distinct synaptic plasticity impairments in the visual cortex (2006)

In the present report, we focused our attention on the role played by the muscarinic acetylcholine receptors (mAChRs) in different forms of long-term synaptic plasticity. Specifically, we investigated long-term potentiation (LTP) and long-term depression (LTD) expression elicited by theta-burst stimulation (TBS) and low-frequency stimulation (LFS), respectively, in visual cortical slices obtained from different mAChR knockout (KO) mice. A normal LTP was evoked in M(1)/M(3) double KO mice, while LTP was impaired in the M(2)/M(4) double KO animals. On the other hand, LFS induced LTD in M(2)/M(4) double KO mice, but failed to do so in M(1)/M(3) KO mice. Interestingly, LFS produced LTP instead of LTD in M(1)/M(3) KO mice. Analysis of mAChR single KO mice revealed that LTP was affected only by the simultaneous absence of both M(2) and M(4) receptors. A LFS-dependent shift from LTD to LTP was also observed in slices from M(1) KO mice, while LTD was simply abolished in slices from M(3) KO mice. Using pharmacological tools, we showed that LTP in control mice was blocked by pertussis toxin, an inhibitor of G(i/o) proteins, but not by raising intracellular cAMP levels. In addition, the inhibition of phospholipase C by U73122 induced the same shift from LTD to LTP after LFS observed in M(1) single KO and M(1)/M(3) double KO mice. Our results indicate that different mAChR subtypes regulate different forms of long-term synaptic plasticity in the mouse visual cortex, activating specific G proteins and downstream intracellular mechanisms.
Spectrally Selective Emitters with Deep Rectangular Cavities Fabricated with Fast Atom Beam Etching (2003)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Hitoshi Sai, Yoshiaki Kanamori, Hiroo Yugami; Spectrally Selective Emitters with Deep Rectangular Cavities Fabricated with Fast Atom Beam Etching. AIP Conf. Proc. 25 January 2003; 653 (1): 155–163. https://doi.org/10.1063/1.1539373 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Abstract 124 (2015)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Assessing immunological and virological responses in the liver: Implications for the cure of chronic hepatitis B virus infection (2022)

Cure from chronic HBV infection is rare with current therapies. Basic research has helped to fundamentally improve our knowledge of the viral life cycle and virus-host interactions, and provided the basis for several novel drug classes that are currently being developed or are being tested in clinical trials. While these novel compounds targeting the viral life cycle or antiviral immune responses hold great promise, we are still lacking a comprehensive understanding of the immunological and virological processes that occur at the site of infection, the liver. At the International Liver Congress 2021 (ILC 2021), a research think tank on chronic HBV infection focused on mechanisms within the liver that facilitate persistent infection and looked at the research questions that need to be addressed to fill knowledge gaps and identify novel therapeutic strategies. Herein, we summarise the discussion by the think tank and identify the key basic research questions that must be addressed in order to develop more effective strategies for the functional cure of HBV infection.
Symmetry-protected topological phases with uniform computational power in one dimension (2017)

We investigate the usefulness of ground states of quantum spin chains with symmetry-protected topological order (SPTO) for measurement-based quantum computation. We show that, in spatial dimension 1, if an SPTO phase protects the identity gate, then, subject to an additional symmetry condition that is satisfied in all cases so far investigated, it can also be used for quantum computation.
Solution structures of the double‐stranded RNA‐binding domains from rna helicase A (2012)

RNA helicase A (RHA) is a highly conserved protein with multifaceted functions in the gene expression of cellular and viral mRNAs. RHA recognizes highly structured nucleotides and catalytically rearranges the various interactions between RNA, DNA, and protein molecules to provide a platform for the ribonucleoprotein complex. We present the first solution structures of the double-stranded RNA-binding domains (dsRBDs), dsRBD1 and dsRBD2, from mouse RHA. We discuss the binding mode of the dsRBDs of RHA, in comparison with the known dsRBD structures in their complexes. Our structural data provide important information for the elucidation of the molecular reassembly mediated by RHA.
In vitro Comparison of Safety and Efficacy of Diluted Isotonic Seawater and Electrodialyzed Seawater for Nasal Hygiene (2020)

Barbara De Servi,1 Marisa Meloni,1 Amina Saaid,2 Josip Culig3 1In Vitro Research Laboratories, VitroScreen SrL, Milan, Italy; 2Department of R&amp;amp;amp;D and Innovation, Laboratoire Fumouze, Levallois-Perret, France; 3Department of Pharmacology and Clinical Pharmacology, University of Applied Health Sciences, Zagreb, CroatiaCorrespondence: Barbara De ServiIn Vitro Research Laboratories, VitroScreen Srl, Via Mos&amp;amp;egrave; Bianchi 103, Milan 20149, ItalyTel +39-02-89077608Fax +39-02-45478817Email barbara.deservi@vitroscreen.comBackground: Nasal irrigation is often used for managing sinonasal conditions and maintaining nasal hygiene, which is critical to overall nasal health and to provide protection against airborne contaminants and pathogens. However, studies comparing efficacies of different solutions are needed.Purpose: This in vitro study evaluated the ionic balance of an isotonic diluted seawater solution (St&amp;amp;eacute;rimar Nasal Hygiene, SNH) and its safety and efficacy for regular nasal hygiene in comparison to electrodialyzed seawater (EDS).Materials and Methods: Ionic balance of SNH, EDS and pure seawater was measured by mass spectrometry and chromatography to be compared to the ionic balance of human plasma as reported in the literature. Safety was measured through cytotoxicity (lactate dehydrogenase release) and pro-inflammation (interleukin-8 secretion) assays using a 3D-reconstituted human nasal epithelium model. For efficacy, adenosine 5&amp;amp;prime;-triphosphate (ATP) release assays, and histological (alcian blue) and immunohistochemical (aquaporin 3) stainings were performed on tissues under hypotonic challenge where saline solution was used as the negative control.Results: Compared to EDS, the ionic balance of SNH was more similar to human plasma and pure seawater. SNH reduced hypotonic stress-associated ATP release and maintained tissue morphology more effectively and lastingly compared to EDS. Both solutions were safe to use on nasal epithelium, as neither of them caused cytotoxicity or induced (pro-) inflammation.Conclusion: In comparison to EDS, this study confirms the safety and efficacy of SNH in maintaining good nasal hygiene consistent with its benefits reported in clinical trials.Keywords: nasal irrigation, electrolyte balance, homeostasis, medical device, nasal mucosa
Internal tibial rotation during in vivo, dynamic activity induces greater sliding of tibio‐femoral joint contact on the medial compartment (2011)

Prognostic studies, Level II.
Effect of Tire Pressure on Efficiency (2013)

Many people ignore tire pressure in their day-to-day lives. In a country striving for maximum efficiency, neglecting to maintain correct tire pressure can noticeably affect the amount of horsepower required to overcome the drag forces due to tire/roadway friction. In order to quantify these horsepower changes, 21 test trials were conducted by allowing a test vehicle to coast from 50 mph down to 20 mph at pressures ranging from 50 psi to 20 psi. After compiling the results, it was shown that lower tire pressures increased the horsepower necessary to propel the automobile.