gebhart/patrepeval huggingface dataset:
AGE–RAGE Stress in the Pathophysiology of Pulmonary Hypertension and its Treatment (2019)

Pulmonary hypertension (PH) is a rare and fatal disease characterized by elevation of pulmonary artery pressure ≥ 25 mm Hg. There are five groups of PH: (1) pulmonary artery (PA) hypertension (PAH), (2) PH due to heart diseases, (3) PH associated with lung diseases/hypoxia, (4) PH associated with chronic obstruction of PA, and (5) PH due to unclear and/or multifactorial mechanisms. The pathophysiologic mechanisms of group 1 have been studied in detail; however, those for groups 2 to 5 are not that well known. PH pathology is characterized by smooth muscle cells (SMC) proliferation, muscularization of peripheral PA, accumulation of extracellular matrix (ECM), plexiform lesions, thromboembolism, and recanalization of thrombi. Advanced glycation end products (AGE) and its receptor (RAGE) and soluble RAGE (sRAGE) appear to be involved in the pathogenesis of PH. AGE and its interaction with RAGE induce vascular hypertrophy through proliferation of vascular SMC, accumulation of ECM, and suppression of apoptosis. Reactive oxygen species (ROS) generated by interaction of AGE and RAGE modulates SMC proliferation, attenuate apoptosis, and constricts PA. Increased stiffness in the artery due to vascular hypertrophy, and vasoconstriction due to ROS resulted in PH. The data also suggest that reduction in consumption and formation of AGE, suppression of RAGE expression, blockage of RAGE ligand binding, elevation of sRAGE levels, and antioxidants may be novel therapeutic targets for prevention, regression, and slowing of progression of PH. In conclusion, AGE-RAGE stress may be involved in the pathogenesis of PH and the therapeutic targets should be the AGE-RAGE axis.
Atomic Response in the Near-Field of Nanostructured Plasmonic Metamaterial (2016)

We report on reflection spectra of cesium atoms in close vicinity of a nanostructured metallic meta-surface. We show that the hyperfine sub-Doppler spectrum of the 6(2)S1/2-6(2)P3/2 resonance transition at 852 nm is strongly affected by the coupling to the plasmonic resonance of the nanostructure. Fine tuning of dispersion and positions of the atomic lines in the near-field of plasmonic metamaterials could have uses and implications for atom-based metrology, sensing, and the development of atom-on-a-chip devices.
Phosphorylated biopolymer-based microcapsules for smart anticorrosion self-healing coating (2020)

International audience
Comparative synthesis of the 3 main European projects dealing with Cooperative Systems (CVIS, SAFESPOT and COOPERS) and description of COOPERS Demonstration Site 4 (2008)

Today's motorways utilize innovative technologies to manage a real-time traffic information database which supplies users with information via FM 107.7 radio, variable message panels and the Internet. In the future, information will be supplied directly to intelligent in-vehicle systems based on GPS technology. This data exchange will be a two-way process, with the vehicle sending information to the infrastructure, and even to other vehicles. Driver, vehicle and infrastructure will form an interactive triangle in which information exchange performs a key function. From this perspective ASFA members are participating to the CVIS, SAFESPOT and COOPERS projects to use the data collecting on the infrastructure, including in-vehicle data, to provide better information on board the vehicle. In this paper, we propose a comparative synthesis of these 3 major European projects dealing with cooperative systems; we introduce the contribution of ASFA members for CVIS and SAFESPOT; a section is dedicated to their contribution for COOPERS. We also introduce the European strategy regarding Intelligent Transport Systems.
Risk Factors of Early Distant Metastasis After Primary Tumor Treatment in Soft Tissue Sarcoma (2022)

The only risk factor for early distant metastasis after primary tumor resection in patients with STS was young age, even though large tumor diameter and histological high grade were risk factors for distant metastasis.
Architecture strategies for energy-efficient packet forwarding in wireless sensor networks (2001)

Article Share on Architecture strategies for energy-efficient packet forwarding in wireless sensor networks Authors: Vlasios Tsiatsis Networked & Embedded Systems Laboratory, E.E. Dept, UCLA, Los Angeles, CA Networked & Embedded Systems Laboratory, E.E. Dept, UCLA, Los Angeles, CAView Profile , Scott Zimbeck Networked & Embedded Systems Laboratory, E.E. Dept, UCLA, Los Angeles, CA Networked & Embedded Systems Laboratory, E.E. Dept, UCLA, Los Angeles, CAView Profile , Mani Srivastava Networked & Embedded Systems Laboratory, E.E. Dept, UCLA, Los Angeles, CA Networked & Embedded Systems Laboratory, E.E. Dept, UCLA, Los Angeles, CAView Profile Authors Info & Claims ISLPED '01: Proceedings of the 2001 international symposium on Low power electronics and designAugust 2001 Pages 92–95https://doi.org/10.1145/383082.383102Online:06 August 2001Publication History 16citation650DownloadsMetricsTotal Citations16Total Downloads650Last 12 Months6Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Caspase-1 as a radio- and chemo-sensitiser in vitro and in vivo (2006)

The cytotoxic effect of anticancer drugs has been shown to involve induction of apoptosis. This observation raises the possibility that factors affecting caspase activation might be important determinants of anticancer drug sensitivity. Ectopic expression of caspase-1 has been shown to trigger apoptosis. However, the role of caspase-1 in apoptosis is now considered as minor compared to other caspases. In patients, high levels of caspase-1 expression may be associated with spontaneous regression in neuroblastomas and with a good clinical response to chemotherapy in acute myeloid leukemia and osteosarcoma. In experimental therapeutics for cancer, caspase-1 has been related to some anticancer activity. These observations led us to examine the effect of over-expression on the response to chemotherapy and radiotherapy in vitro and in vivo. Caspase-1 expression mediated by an adenoviral vector was able to kill directly cells and to sensitise the remaining cells to cisplatin or gamma-radiation in vitro. In HeLa cells stably transfected with caspase-1, sensitisation to cisplatin was due to an amplification of the cisplatin-induced mitochondrial apoptotic pathway activation. Caspase-1 mediated sensitisation to cisplatin and gamma-radiation was also observed in vivo. Altogether, we conclude that caspase-1 can act as a radio- and chemo-sensitiser, in vitro and in vivo.
Metastasis-Promoting Genes (2011)

Accurately defining whether a tumor is benign or malignant is critical in determining the most appropriate course of therapy and, consequently, clinical outcome. Benign tumors, which are characterized by hyperproliferating cells, can, in most cases, be effectively treated by surgical removal if the tumor is located in an accessible and nonessential site in the body. However, when a tumor becomes malignant – acquiring dysplasia, dedifferentiation, and metastatic properties – treatment becomes extremely difficult because of profound genetic and epigenetic changes in the tumor that counteract host defense mechanisms, as well as exogenously delivered therapeutics [1]. Additionally, effective delivery to metastatic lesions can be difficult and inefficient. This chapter focuses on the genes and their products that have been identified and shown to be involved in regulating metastasis.
Relationships between External, Wearable Sensor-Based, and Internal Parameters: A Systematic Review (2023)

Micro electro-mechanical systems (MEMS) are used to record training and match play of intermittent team sport athletes. Paired with estimates of internal responses or adaptations to exercise, practitioners gain insight into players' dose-response relationship which facilitates the prescription of the training stimuli to optimize performance, prevent injuries, and to guide rehabilitation processes. A systematic review on the relationship between external, wearable-based, and internal parameters in team sport athletes, compliant with the PRISMA guidelines, was conducted. The literature research was performed from earliest record to 1 September 2020 using the databases PubMed, Web of Science, CINAHL, and SportDISCUS. A total of 66 full-text articles were reviewed encompassing 1541 athletes. About 109 different relationships between variables have been reviewed. The most investigated relationship across sports was found between (session) rating of perceived exertion ((session-)RPE) and PlayerLoad™ (PL) with, predominantly, moderate to strong associations (r = 0.49-0.84). Relationships between internal parameters and highly dynamic, anaerobic movements were heterogenous. Relationships between average heart rate (HR), Edward's and Banister's training impulse (TRIMP) seem to be reflected in parameters of overall activity such as PL and TD for running-intensive team sports. PL may further be suitable to estimate the overall subjective perception. To identify high fine-structured loading-relative to a certain type of sport-more specific measures and devices are needed. Individualization of parameters could be helpful to enhance practicality.
Neutralization of high pH and alkalinity effluent from recycled concrete aggregate by common subgrade soil (2020)

Use of recycled concrete aggregate (RCA) as highway basecourse material conserves virgin aggregate, reduces energy consumption and CO<sub>2</sub> emissions, and may also decrease costs during construction. However, concerns remain over possible negative environmental impacts associated with high pH (>11) effluent from RCA in contact with water. This study examines the reactive transport of high-pH and high-alkalinity water, modeled on RCA leachate, through model subgrade soils. By developing an understanding of the reactions controlling effluent neutralization, this study aims to quantify the change in pH from the discharge site through surrounding subgrade soils. Four types of subgrade soils with a range of mineral composition, Atterberg limits, and cation exchange capacities (CECs) are examined. They include a clayey sand (SC10), low-plasticity clays (M14, SC25), and a high-plasticity clay (CH38). Batch reaction experiments are used to develop kinetic parameters describing the neutralization of high-pH and -alkalinity leachate by clay minerals through mineral dissolution and reprecipitation. Given this information, a reactive transport model incorporating advection, diffusion, and reaction is used to model the change in pH as a function of distance traveled through model subgrade soils and is applied to laboratory-scale column experiments. The rate at which the high pH front travels is directly related to a soil's clay mineral content. Soils with high CECs effectively delay the propagation of hydroxide front by the dissolution of clay minerals. This study demonstrates that common subgrade soils with moderate clay content will effectively neutralize high pH leachate initially produced by RCA.
Correction to Copper(I)-Catalyzed Cycloaddition of 4-Bromosydnones and Alkynes for the Regioselective Synthesis of 1,4,5-Trisubstituted Pyrazoles (2015)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionORIGINAL ARTICLEThis notice is a correctionCorrection to Copper(I)-Catalyzed Cycloaddition of 4-Bromosydnones and Alkynes for the Regioselective Synthesis of 1,4,5-Trisubstituted PyrazolesElodie Decuypere, Simon Specklin, Sandra Gabillet, Davide Audisio, Hui Liu, Lucie Plougastel, Sergii Kolodych, and Frédéric Taran*Cite this: Org. Lett. 2015, 17, 4, 1062Publication Date (Web):January 30, 2015Publication History Received19 January 2015Published online30 January 2015Published inissue 20 February 2015https://pubs.acs.org/doi/10.1021/acs.orglett.5b00175https://doi.org/10.1021/acs.orglett.5b00175correctionACS PublicationsCopyright © 2015 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1105Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (178 KB) Get e-Alertsclose Get e-Alerts
Development of a Method to Evaluate the Puncture Resistance of Protective Clothing Materials (1992)

Various parameters relevant to the puncture resistance of protective clothing materials were studied. The experimental set-up was installed in an Instron testing machine. Testing was performed in a compression mode. A point was installed in a 890-newton (200-lb) load compression force cell in the movable arm of the machine, and a sample support was installed in the fixed arm in the base. The first parameter analyzed was point geometry. Three geometries were evaluated: conical, hemispheric and flat points. The effect of the diameter of the points on the results of the puncture test was also evaluated. A neoprene material with three different thicknesses (0.41 mm, 0.7 9 mm and 1.57 mm) was used as reference material. The tests were performed at various speeds of the movable arm from 10 to 500 mm/min. Results showed that the point having a hemispheric geometry gives the best reproducibility. Hemispheric geometry points were therefore used to test the puncture resistance of commercially available gloves. A classification of the gloves into four groups is proposed.
A document corpus browser for in-depth reading (2004)

Software tools, including Web browsers, e-books, electronic document formats, search engines, and digital libraries are changing the way people read, making it easier for them to find and view documents. However, while these tools provide significant help with short-term reading projects involving small numbers of documents, they provide less help with longer-term reading projects, in which a topic is to be understood in depth by reading many documents. For such projects, readers must find and manage many documents and citations, remember what has been read, and prioritize what to read next. This paper describes three integrated software tools that facilitate in-depth reading. A first tool extracts citation information from documents. A second finds on-line documents from their citations. The last is a document corpus browser that uses a zoomable user interface to show a corpus at multiple granularities while supporting reading tasks that take days, weeks, or longer. We describe these tools and the design principles that motivated them.
Current sensor based on an atomic magnetometer for DC application (2020)

A DC current sensor based on an optically pumped atomic magnetometer is proposed. It has a high linearity in a wide operation range, since the magnetometer measures the absolute magnitude of the magnetic field produced by the current to be measured. The current sensor exhibits a high accuracy with a non-moment solenoid and magnetic shielding to suppress the influence from the environment. The absolute error of the measured current is below 0.08 mA when the range is from 7.5 mA to 750 mA. The relative error is 5.54 × 10?5 at 750 mA.
Update on prostate biopsy technique (2004)

Current reports have suggested that: (1) extended biopsy schemes decrease the false-negative rate compared with conventional sextant biopsy; (2) laterally directed biopsies from the anterior horn should be included in extended biopsy protocols; and (3) local anesthesia reduces pain associated with extended biopsy.
Capture Sequencing Enables Sensitive Detection of Tick-Borne Agents in Human Blood (2022)

Assay sensitivity can be a limiting factor in the use of PCR as a tool for the detection of tick-borne pathogens in blood. We evaluated the performance of Tick-borne disease Capture Sequencing Assay (TBDCapSeq), a capture sequencing assay targeting tick-borne agents, to test 158 whole blood specimens obtained from the Lyme Disease Biobank. These included samples from 98 individuals with signs and symptoms of acute Lyme disease, 25 healthy individuals residing in Lyme disease endemic areas, and 35 samples collected from patients admitted to the Massachusetts General Hospital or referred to the infectious disease clinic. Compared to PCR, TBDCapSeq had better sensitivity and could identify infections with a wider range of tick-borne agents. TBDCapSeq identified a higher rate of samples positive for Borrelia burgdorferi (8 vs. 1 by PCR) and Babesia microti (26 vs. 15 by PCR). TBDCapSeq also identified previously unknown infections with Borrelia miyamotoi , Ehrlichia , and Rickettsia species. Overall, TBDCapSeq identified a pathogen in 43 samples vs. 23 using PCR, with four co-infections detected versus zero by PCR. We conclude that capture sequencing enables superior detection of tick-borne agents relative to PCR.
Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond (2008)

A major finding--that (-)-trans-Delta(9)-tetrahydrocannabinol (Delta(9)-THC) is largely responsible for the psychotropic effects of cannabis--prompted research in the 1970s and 1980s that led to the discovery that this plant cannabinoid acts through at least two types of cannabinoid receptor, CB(1) and CB(2), and that Delta(9)-THC and other compounds that target either or both of these receptors as agonists or antagonists have important therapeutic applications. It also led to the discovery that mammalian tissues can themselves synthesize and release agonists for cannabinoid receptors, the first of these to be discovered being arachidonoylethanolamide (anandamide) and 2-arachidonoylglycerol. These 'endocannabinoids' are released onto their receptors in a manner that appears to maintain homeostasis within the central nervous system and sometimes either to oppose or to mediate or exacerbate the unwanted effects of certain disorders. This review provides an overview of the pharmacology of cannabinoid receptors and their ligands. It also describes actual and potential clinical uses both for cannabinoid receptor agonists and antagonists and for compounds that affect the activation of cannabinoid receptors less directly, for example by inhibiting the enzymatic hydrolysis of endocannabinoids following their release.
Correction: HIV-1 anchor inhibitors and membrane fusion inhibitors target distinct but overlapping steps in virus entry (2022)

Funding and additional information should read as follows: This work was supported by Aids Fonds Netherlands Grants 2005021 and 2008013, the Bill and Melinda Gates Foundation Collaboration for AIDS Vaccine Discovery (CAVD) Grants OPP1111923 and OPP1132237, National Institutes of Health Grant P01 AI110657 and funding from European Union's Horizon 2020 research and innovation programme under grant agreement No 681137.
Present status and problems of fire fighting robots (2003)

Firefighting and rescue activity are considered risky mission. They are an ideal target for robot technology to keep away fire fighters from danger. Moreover, it makes possible to rescue much more victims. Some fire departments have already developed and deployed fire fighting and rescue robots. However, the performance of the robots is not enough. The author considers and examines them from two points of view: "size and weight" and "cost and performance". Base on the considerations, the author proposes five important elements to develop useful and reasonable priced robots for fire departments. The robots should make possible to save and rescue much more lives.
ChemInform Abstract: N‐Methylanilines from Benzylic Azides. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Effect of Gan interlayer thickness on the Algan/Gan heterostructure field-effect transistors for self-terminated wet etching process (2016)

In this paper, we investigated the effect of GaN interlayer thickness and AlGaN back barrier layer on the material and electrical properties of AlGaN/GaN HFETs. When the thickness of GaN interlayer is approximately 3 and 5 nm, it will slightly increase surface roughness and degrades 2DEG carrier density. The 2DEG channel is also up shifted to nearly beneath the GaN interlayer. By contrast, 10 nm GaN interlayer causes a clear double channel and an obvious degradation of 2DEG carrier density. It is also demonstrated that the introduction of AlGaN back barrier layer can effectively improve the 2DEG confinement and reduce the scattering, resulting in smaller frequency dispersion effect. HFETs fabricated on the sample with both back barrier layer and 5 nm GaN interlayer present good pinch-off characteristics and high on/off ratio of approximately 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">7</sup> . This optimized structure is suitable for application in self-terminated wet etching process.
Structural genomics and the Protein Data Bank (2021)

The field of Structural Genomics arose over the last 3 decades to address a large and rapidly growing divergence between microbial genomic, functional, and structural data. Several international programs took advantage of the vast genomic sequence information and evaluated the feasibility of structure determination for expanded and newly discovered protein families. As a consequence, structural genomics has developed structure-determination pipelines and applied them to a wide range of novel, uncharacterized proteins, often from "microbial dark matter," and later to proteins from human pathogens. Advances were especially needed in protein production and rapid de novo structure solution. The experimental three-dimensional models were promptly made public, facilitating structure determination of other members of the family and helping to understand their molecular and biochemical functions. Improvements in experimental methods and databases resulted in fast progress in molecular and structural biology. The Protein Data Bank structure repository played a central role in the coordination of structural genomics efforts and the structural biology community as a whole. It facilitated development of standards and validation tools essential for maintaining high quality of deposited structural data.