gebhart/patrepeval huggingface dataset:
Morphology and internal structure control of rod–coil copolymer aggregates by mixed selective solvents (2011)

The molecular packing of rod–coil copolymers, which relates closely to their aggregate morphology, significantly influences their optoelectronic properties. The morphological phase diagram of rod–coil block copolymers in mixed selective solvents and the internal structures of the resulting aggregates are studied by using dissipative particle dynamics. The coil-selective solvent is mixed well with the rod-selective solvent and the effective solvent quality can be tuned by their relative amount. The diverse morphologies and morphological transitions of structural aggregates induced by mixed solvents depend on the mixed solvent composition, rod-block length, and copolymer concentration. Our simulation results show that while the overall morphology of the aggregate is controlled primarily by the rod length and polymer concentration, the domain morphology within the aggregate, as well as the degree of local rod alignment, are primarily controlled by the rod length and solvent quality. Specifically, we observe that spheres, cylinders, perforated sheets, and three-dimensional networks are sequentially formed with increasing rod length or copolymer concentration irrespective of the solvent quality. On the other hand, changing the solvent quality influences the morphology within an aggregate both by determining any preference for the exposed surface of the aggregate, and also because the rod-selective solvent tends to disrupt the orderly packing of the rod blocks. The range of morphologies within the aggregate is even richer, and interesting structures, such as an inverted vesicle, a structural sphere, an inverted cylindrical vesicle, a segmented cylinder, and a segmented network are observed. Unique segmented-like structures exhibiting the most ordered conformation in the rod domains appear when roughly equal amounts of rod- and coil-selective solvents are used.
mQTL.NMR: An Integrated Suite for Genetic Mapping of Quantitative Variations of <sup>1</sup>H NMR-Based Metabolic Profiles (2015)

High-throughput (1)H nuclear magnetic resonance (NMR) is an increasingly popular robust approach for qualitative and quantitative metabolic profiling, which can be used in conjunction with genomic techniques to discover novel genetic associations through metabotype quantitative trait locus (mQTL) mapping. There is therefore a crucial necessity to develop specialized tools for an accurate detection and unbiased interpretability of the genetically determined metabolic signals. Here we introduce and implement a combined chemoinformatic approach for objective and systematic analysis of untargeted (1)H NMR-based metabolic profiles in quantitative genetic contexts. The R/Bioconductor mQTL.NMR package was designed to (i) perform a series of preprocessing steps restoring spectral dependency in collinear NMR data sets to reduce the multiple testing burden, (ii) carry out robust and accurate mQTL mapping in human cohorts as well as in rodent models, (iii) statistically enhance structural assignment of genetically determined metabolites, and (iv) illustrate results with a series of visualization tools. Built-in flexibility and implementation in the powerful R/Bioconductor framework allow key preprocessing steps such as peak alignment, normalization, or dimensionality reduction to be tailored to specific problems. The mQTL.NMR package is freely available with its source code through the Comprehensive R/Bioconductor repository and its own website ( http://www.ican-institute.org/tools/ ). It represents a significant advance to facilitate untargeted metabolomic data processing and quantitative analysis and their genetic mapping.
Relación entre la capacidad física y la calidad de vida en trabajadores de una institución universitaria (2010)

Resumen es: Objetivo. Estudiar la relacion entre la capacidad fisica (CF) por VO2max calculado y la calidad de vida relacio- nada con la salud (CVRS) en trabajadores...
Electronic Structure and Quadratic Hyperpolarizabilities in Organotransition-Metal Chromophores Having Weakly Coupled .pi.-Networks. Unusual Mechanisms for Second-Order Response (1994)

International audience
TNFα receptor expression in rat cardiac myocytes: TNFα inhibition of L‐type Ca<sup>2+</sup> current and Ca<sup>2+</sup> transients (1995)

Tumor necrosis factor-alpha (TNF alpha) is a potentially powerful anti-neoplastic agent; however, its therapeutic usefulness is limited by its cardiotoxic and negative inotropic effects. Accordingly, studies were undertaken to gain a better understanding of the mechanisms of TNF alpha-mediated cardiodepression. Single cell RT-PCR, [125I]TNF alpha ligand binding and Western immunoblotting experiments demonstrated that rat cardiac cells predominantly express type I TNF alpha receptors (TNFRI or p60). TNF alpha inhibited cardiac L-type Ca2+ channel current (ICa) and contractile Ca2+ transients. Thus, it is possible that the negative inotropic effects of TNF alpha are the result of TNFRI-mediated blockade of cardiac excitation-contraction coupling.
Classifiers: a theoretical and empirical study (1991)

This paper describes how a competitive tree learning algorithm can be derived from first principles. The algorithm approximates the Bayesian decision theoretic solution to the learning task. Comparative experiments with the algorithm and the several mature AI and statistical families of tree learning algorithms currently in use show the derived Bayesian algorithm is consistently as good or better, although sometimes at computational cost. Using the same strategy, we can design algorithms for many other supervised and model learning tasks given just a probabilistic representation for the kind of knowledge to be learned. As an illustration, a second learning algorithm is derived for learning Bayesian networks from data. Implications to incremental learning and the use of multiple models are also discussed. 1 Introduction Systems for learning classification trees [ Quinlan, 1986; Cestnik et al., 1987 ] are common in machine learning, statistics and pattern recognition. Despite these suc...
ChemInform Abstract: Alkaline‐Earth Beryllium Borate CaBeB2O5. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Adsorption Behaviors and Mechanisms of Humic Substances by Thermally Oxidized Graphitic Carbon Nitride (2023)

Thermal oxidation is efficient for enhancing the photocatalysis performance of graphitic carbon nitride (g-C<sub>3</sub>N<sub>4</sub>), while its effect on adsorption performance has not been fully studied, which is crucial to the application of g-C<sub>3</sub>N<sub>4</sub> as adsorbents and photocatalysts. In this study, thermal oxidation was used to prepare sheet-like g-C<sub>3</sub>N<sub>4</sub> (TCN), and its application for adsorption of humic acids (HA) and fulvic acids (FA) was evaluated. The results showed that thermal oxidation clearly affected the properties of TCN. After thermal oxidation, the adsorption performance of TCN was enhanced significantly, and the adsorption amount of HA increased from 63.23 (the bulk g-C<sub>3</sub>N<sub>4</sub>) to 145.35 mg/g [TCN prepared at 600 °C (TCN-600)]. Based on fitting results using the Sips model, the maximum adsorption amounts of TCN-600 for HA and FA were 327.88 and 213.58 mg/g, respectively. The adsorption for HA and FA was markedly affected by pH, alkaline, and alkaline earth metals due to electrostatic interactions. The major adsorption mechanisms included electrostatic interactions, π-π interactions, hydrogen bonding, along with a special pH-dependent conformation (for HA). These findings implied that TCN prepared from environmental-friendly thermal oxidation showed promising prospects for humic substances (HSs) adsorption in natural water and wastewater.
Treatment delay and reperfusion management of acute ST-segment elevation myocardial infarction: analysis of the China STEMI Care Project Phase 1 (2020)

Although a long treatment delay and a high proportion of patients transporting themselves to the hospital were observed, trends were positive with greater adoption of primary PCI and lower in-hospital mortality in tertiary hospitals in China. Our results provided important information for further integrated STEMI network construction in China.
tPA contributes to impaired NMDA cerebrovasodilation after traumatic brain injury through activation of JNK MAPK (2011)

These data indicate that tPA contributes to impairment of NMDA-mediated cerebrovasodilation after FPI through JNK, while p38 may be protective. These data suggest that inhibition of the endogenous plasminogen activator system and JNK may improve cerebral hemodynamic outcome post-TBI.
Randomized phase IIb trial evaluating the therapeutic vaccine TG4010 (MVA-MUC1-IL2) as an adjunct to chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) (2008)

8023 Background: TG4010 is a recombinant Modified Virus Ankara (MVA) expressing both IL2 and the tumor-associated antigen MUC1. Methods: This is a randomized, open label and multicenter study. Eligibility criteria were: histologically documented and untreated stage IIIB “wet”/IV NSCLC, MUC1 positive tumor, ECOG PS 0–1. Patients were randomized to receive: Cisplatin 75mg/m2 on d1 and Gemcitabine 1250mg/m2 on d1 and d8 every 3 weeks for up to 6 cycles with or without TG4010 which was continued upon progression. Tumors were evaluated every 6 weeks (WHO criteria). Primary endpoint was progression-free survival (PFS) at 6 months; secondary endpoints included overall survival, response rate, safety, quality of life and immune response. Results: 148 patients were randomized: 107 men / 41 women, mean age: 59 years, 134 patients with stage IV disease / 14 with stage IIIB, 105 patients with PS 1 / 43 with PS 0. Demographics did not differ between both arms. The preliminary efficacy results provided by local evaluation on 140 evaluable patients are the following: in the experimental arm, 30/70 patients (43%; 95% CI 0.31–0.55) presented a confirmed partial response (PR) versus 18/70 (26%; 95% CI 0.16–0.36) in the control arm. Most adverse events (AEs) were considered related to chemotherapy or to underlying disease. Hematologic toxicity was equivalent in both arms. Most frequent AEs related to TG4010 were injection site reactions and asthenia, classical vaccine associated reactions. Preliminary immune response analysis indicates that both MUC1-specific and non-specific cellular immune responses are associated with the activity of TG4010. As median follow-up is 9 months, PFS, immune response and overall survival data are not yet mature but will be presented at the meeting. Conclusions: Based on preliminary data, the combination of TG4010 with first-line chemotherapy in NSCLC shows promising results with an increased response rate and a good safety profile. Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Transgene SA Transgene SA Transgene
Cell-based multicast grouping in large-scale virtual environments (poster session) (extended abstract) (2000)

No abstract available.
Video 4 from Impact of Metabolic Heterogeneity on Tumor Growth, Invasion, and Treatment Outcomes (2023)

&lt;p&gt;Video 4: Chemotherapy. Simulation of chemotherapy&lt;/p&gt;
Flux observer enhanced with low-frequency signal injection allowing sensorless zero-frequency operation of induction motors (2004)

In sensorless induction motor drives, flux estimators based only on the fundamental-wave motor model work well at sufficiently high stator frequencies, but they fail at speeds close to zero. To solve this problem, a new observer structure is proposed, combining a speed-adaptive full-order flux observer with a low-frequency signal injection method. An error signal obtained from the signal injection method is used as an additional feedback signal in the speed-adaptation law of the observer, resulting in a wide speed range, excellent dynamic properties, and zero-frequency operation capability. The enhanced observer is also robust against parameter errors. Experimental results are shown, including very slow speed reversals and long-term zero-frequency operation under rated load torque, as well as rated load torque steps and fast speed reversals under rated load torque.
Rate Splitting Multiple Access for Sum-Rate Maximization in IRS Aided Uplink Communications (2022)

In this paper, an intelligent reflecting surface (IRS) aided uplink (UL) rate-splitting multiple access (RSMA) system is investigated for dead-zone users where the direct link between the users and the base station (BS) is unavailable and the UL transmission is carried out only through IRS. In the considered RSMA system, a message of each user is split into several sub-messages and each part contributes to the rate of that user and depending upon split proportions BS decodes them using appropriate decoding order. The problem of sum-rate maximization is formulated to jointly design the optimal power allocation at each UL user, passive beamforming at the IRS under optimal decoding order of sub-messages. Due to non-convexity and discrete non-linear programming of the formulated problem, the original problem is intractable and hence, we decouple the problem into different sub-problems in which the problems of power allocation and passive beamforming are alternatively solved under using successive convex approximation and Riemaniann conjugate gradient algorithms, respectively. Moreover, the decoding order strategy is analytically derived which confirm that the optimal decoding order strategy depend upon decreasing order of channel gain of users and increasing order of split proportions of sub-messages. Later, the unified solution based on block-coordinate descent (BCD) algorithm is proposed. Simulation results validate that the proposed decoding order scheme attains performance closer to the optimal solution with low computational complexity. Moreover, the proposed IRS aided RMSA system outperforms the system with non-orthogonal multiple access (NOMA) and orthogonal multiple access (OMA) schemes in terms of achievable sum-rate throughput.
Intramolecular Friedel-Crafts cyclization of nitrogen heterocycles. An expeditious approach to the azaphenanthrene skeleton (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIntramolecular Friedel-Crafts cyclization of nitrogen heterocycles. An expeditious approach to the azaphenanthrene skeletonJose Barluenga, Miguel Tomas, Angel Suarez-Sobrino, and Eduardo RubioCite this: J. Org. Chem. 1993, 58, 3, 700–704Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/jo00055a025https://doi.org/10.1021/jo00055a025research-articleACS PublicationsRequest reuse permissionsArticle Views326Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Bacterial-induced Inflammation in Germ-free Rabbit Appendix (2005)

The intestinal ecosystem is defined by a series of interactions between the microbiota, the mucosal epithelium, and the gut-associated lymphoid tissue (GALT). Perturbations in the fine balance of the interactions between these components can result in gastrointestinal diseases such as inflammatory bowel disease (IBD). The pathophysiology of IBD is thought to develop as a result of dysregulated mucosal immune responses to normal luminal microflora. Several animal models for IBD have been developed and underscore the role of the immune system in development of disease. Most of the existing animal models studying IBD are based on the use of chemically induced IBD or of genetically modified and germ-free animals. It is, however, important to study inflammatory responses that can develop from interactions between bacteria, the mucosal epithelium, and GALT in animals that are not genetically modified or immunocompromised. In this report, we document the use of a germ-free ligated rabbit appendix model to induce inflammatory changes in response to specific bacteria. With the introduction of a Bacteroides vulgatus isolate from humans into the germ-free ligated appendix, we found chronic inflammatory changes, including glandular distortion, gland drop-out, decreased goblet cells, and crypt abscess formation. However, with the introduction of other experimental luminal contents, we observed no inflammation. These results show that specific microbial composition can induce inflammation. We suggest that this model may be useful to study the mechanism by which specific bacteria establish inflammatory responses in the gut.
Multimodal imaging: Nanocrystal loaded PLA-shelled contrast agents (2015)

Ultrasound Contrast Agents (UCA) are microencapsulated gas bubbles used to increase the overall contrast of the ultrasound (US) image. Novel multimodal polymeric UCA containing additional contrast agents that are active in multiple imaging modalities have been developed. Four platforms of loaded poly (lactic acid) (PLA) shelled UCA are presented. The first two platforms co-encapsulate aqueous or organic Quantum Dots (QD). The third platform contains magnetic iron oxide nanoparticles (MNP). The fourth platform contains gold nanoparticles (AuNP). All platforms showed that the properties of UCA are maintained as well as the properties of additional encapsulated contrast agent. This study explores the potential application for improving the screening of a subject using at least two different modalities.
Golf ball mark severity and recovery as affected by mowing height, rolling frequency, foot traffic, and moisture (2017)

Putting greens experience stress from golf balls striking the surface, maintenance equipment, and foot traffic. Improved creeping bentgrass (Agrostis stolonifera L.) cultivars, sand-based root zones, and skilled superintendents maintain plant health while providing firmer conditions. Many researchers have studied effects of compaction and wear on putting greens, but few have determined the effect of these stresses on ball marks. The objective of this research was to evaluate ball mark severity and recovery of creeping bentgrass under different mowing heights (2.5, 3.2, and 4.0 mm), rolling frequencies (0, 3, or 6 d wk–¹), and foot traffic using digital image analysis. Digital images of golf balls placed in the depression were used to calculate ball mark depth, and a cover analysis was conducted to model ball mark injury area using a one phase decay model to determine theoretical maximum injury, slope, and days to 50% recovery. Soil moisture content was positively correlated with ball mark depth, but common stresses rarely altered ball mark depth. The mean theoretical maximum ball mark injury was 377 mm² greater for daily rolled treatments in 2010 compared to non-rolled treatments. The slope of recovery rarely changed among treatments suggesting that theoretical maximum ball mark injury area has a greater effect on recovery. Lastly, combining the lowest mowing height or daily rolling and foot traffic slowed the time ball marks took to reach 50% recovery. This research demonstrates the effects common management practices and soil moisture have on the severity and recovery of ball marks during environmental stress.
Contact Discharge Welding and Non-contact Discharge Welding for Nickel Particles (2009)

Nickel particles of several tens μm were welded to a gold substrate by contact discharge welding and the joints were strengthened by non-contact discharge welding under various conditions. They can be welded at the same condition that the gold particles were welded, as described in our previous paper. The non-contact discharge welding was carried out in N2 gas flow, in Ar gas flow and in He gas flow. The fracture load of the joints welded in N2 gas flow were higher than those welded in Ar or He gas flow, though cracks were observed in some samples. Preheating of N2 gas and substrate were effective to suppress the generation of cracks to some degree. The fracture stress of the joint was about one sixth of base nickel, because of oxidation during welding.
Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation (1987)

In the presence of lovastatin (mevinolin), an inhibitor of endogenous mevalonate synthesis, C1300 murine neuroblastoma cells incorporated (2-14C)mevalonate into several discrete polypeptides that were separable by SDS-PAGE. The electrophoretic pattern of the labeled proteins did not vary substantially when cells were homogenized with Ca++, Mg++, high concentrations of NaCl or phosphatase inhibitor, or when cells were lysed immediately in trichloroacetic acid. When cells that had been prelabeled with (14C)mevalonate were incubated with lovastatin and simultaneously deprived of exogenous mevalonate, there was a 50-60% decline in the concentration of protein-bound isoprenoid label within 17 h. In contrast, there was little change in the radioactivity in the sterol, dolichol, or ubiquinone fractions. The time course of the decline in mevalonate-derived label in cellular polypeptides paralleled the onset of neurite outgrowth and preceded the decline of DNA synthesis, suggesting that a decreased intracellular concentration of protein-bound isoprenoid groups may contribute to the well-documented effects of mevalonate deprivation on cell morphology and cell cycling. Fractionation of neuroblastoma cells by differential centrifugation and sucrose density-gradient centrifugation revealed that mevalonate-labeled proteins of 53 kDA, 22-26 kDa, and 17 kDa were concentrated in the cytosol. Proteins migrating at 45 kDa were found in both the soluble and particulate fractions, including those enriched in mitochondria and plasma membrane. The isoprenylated proteins migrating at approximately 66 kDa were localized exclusively in the nuclear fraction. When chromatin was removed from the nuclei by extraction with 2 M NaCl, the 66 kDa isoprenylated proteins remained associated with the residual components of the nuclear matrix and lamina. Isoprenylated proteins with electrophoretic mobilities similar to those observed in neuroblastoma cells were detected in a variety of established cell lines. However, there was considerable variation among cell lines in the overall efficiency of protein labeling with (14C) mevalonate and in the prominence and mobilities of specific labeled proteins in the 45-70 kDa range. Comparisons of paired transformed vs. nontransformed fibroblast cell lines suggested that the profile of mevalonate-labeled proteins in a given cell line is not altered by malignant transformation.(ABSTRACT TRUNCATED AT 400 WORDS)