gebhart/patrepeval huggingface dataset:
Three-dimensional measurement by high-speed line-field Fourier-domain optical coherence tomography in vivo (2006)

A high-speed line-field Fourier-domain optical coherence tomography system has been developed. Tomographic images consisting of 656 A-lines are obtained at 121 frames per second. It is corresponding to 79,400 A-line/s. Three-dimensional volume sets consist of 256 OCT images are measured within 2.1 seconds. The sensitivity of this system is 79.5 dB. A biological tissue measurement is demonstrated with human nail fold in vivo. The three-dimensional nail fold structure is visualized.
Quality-of-Service Measurements (2006)

In the UMTS network, UTRAN, PS core, CS core, and UMTS QoS architecture form a framework for QoS measurements, which have to be performed to ensure that a UMTS subscriber is served properly. The true picture of QoS is perceived by acquisition signaling and user-plane data from the network interfaces, and performing analysis for those. From an operator's perspective, the QoS consists of several factors, each of which brings different kinds of measuring requirements for the operator when developing and operating the UMTS network. Protocol decoding, signaling procedure analysis, and tracing of the subscriber dedicated protocol messages are needed for testing, verifying, and troubleshooting the UMTS network in live or laboratory environments. The traffic and capacity-measurement challenges rely on the interfaces where the user data is transferred over a packet or a circuit switched domain where the most important key performance indicators (KPI) are related to delay and throughput. KPI values, generated by statistical measurements, may be used to express the service availability or the behavior of the radio access or core network domain. Moreover, sophisticated protocol analyzers and network probes are the basic tools for acquisition, decoding, and analyzing the protocol layers, and they form the base for more intelligent post-processing or real-time applications.
Topology Optimization of Micromachined Structures With the Manufacturing Constraints of KOH Etching of (110) Silicon (2008)

The focus of this paper is on designing useful compliant micro-mechanisms of high-aspect-ratio which can be microfabricated by the cost-effective wet etching of (110) orientation silicon (Si) wafers. Wet etching of (110) Si imposes constraints on the geometry of the realized mechanisms because it allows only etch-through in the form of slots parallel to the wafer’s flat with a certain minimum length. In this paper, we incorporate this constraint in the topology optimization and obtain compliant designs that meet the specifications on the desired motion for given input forces. Using this design technique and wet etching, we show that we can realize high-aspect-ratio compliant micro-mechanisms. For a (110) Si wafer of 250 μm thickness, the minimum length of the etch opening to get a slot is found to be 866 μm. The minimum achievable width of the slot is limited by the resolution of the lithography process and this can be a very small value. This is studied by conducting trials with different mask layouts on a (110) Si wafer. These constraints are taken care of by using a suitable design parameterization rather than by imposing the constraints explicitly. Topology optimization, as is well known, gives designs using only the essential design specifications. In this work, we show that our technique also gives manufacturable mechanism designs along with lithography mask layouts. Some designs obtained are transferred to lithography masks and mechanisms are fabricated on (110) Si wafers.
Analysis and annotation of genome-wide DNA methylation patterns in two nonhuman primate species using the Infinium Human Methylation 450K and EPIC BeadChips (2020)

Abstract The Infinium Human Methylation450 and Methylation EPIC BeadChips are useful tools for the study of the methylation state of hundreds of thousands of CpG across the human genome at affordable cost. However, in a wide range of experimental settings in particular for studies in infectious or brain-related diseases, human samples cannot be easily obtained. Hence, due to their close developmental, immunological and neurological proximity with humans, non-human primates are used in many research fields of human diseases and for preclinical research. Few studies have used DNA methylation microarrays in simian models. Microarrays designed for the analysis of DNA methylation patterns in the human genome could be useful given the genomic proximity between human and nonhuman primates. However, there is currently information lacking about the specificity and usability of each probe for many nonhuman primate species, including rhesus macaques ( Macaca mulatta ), originating from Asia, and African green monkeys originating from West-Africa ( Chlorocebus sabaeus) . Rhesus macaques and African green monkeys are among the major nonhuman primate models utilized in biomedical research. Here, we provide a precise evaluation and re-annotation of the probes of the two microarrays for the analysis of genome-wide DNA methylation patterns in these two Cercopithecidae species. We demonstrate that up to 162,000 of the 450K and 255,000 probes of the EPIC BeadChip can be reliably used in Macaca mulatta or Chlorocebus sabaeus . The annotation files are provided in a format compatible with a variety of preprocessing, normalization and analytical pipelines designed for data analysis from 450K/EPIC arrays, facilitating high-throughput DNA methylation analyses in Macaca mulatta and Chlorocebus sabaeus . They provide the opportunity to the research community to focus their analysis only on those probes identified as reliable. The described analytical workflow leaves the choice to the user to balance coverage versus specificity and can also be applied to other Cercopithecidae species.
Accuracy of asthma statistics from death certificates in South Australia (1992)

The accuracy of death certificate data on asthma for the age group 65 years and over would be too low at present for most epidemiological purposes.
Multicore optical fibres for astrophotonics (2011)

We report progress towards multimode (MM) fibre filters for suppressing the OH emission that hinders ground based observation of the early Universe. Fibre Bragg gratings (FBGs) can filter these narrow spectral lines in single-mode (SM) fibres. Implementing them in MM fibres well-matched to astronomical instruments requires transitions between the MM fibre and several SM fibres. Such hand-crafted "photonic lanterns" require many identical FBGs to be made and spliced in place. Instead we are pursuing the idea in multicore (MC) fibres. The FBG is written at once in all the SM cores. The fibre is jacketed with low-index glass and tapered to form the core and cladding of a MM fibre, giving a monolithic FBG filter with conventional MM ports. Such a device can stand alone, or be incorporated into more elaborate instruments.
Establishment of a bioassay to determine serum levels of dextran sulfate and pentosan polysulfate, two potent inhibitors of human immunodeficiency virus. (1990)

Dextran sulfate and pentosan polysulfate are two promising candidate anti-acquired immune deficiency syndrome (AIDS) drugs that have already been the subject of initial clinical trials in patients with AIDS. There is at present no reliable assay method to monitor blood drug levels in humans following the administration of either drug. We have now developed a sensitive bioassay system based on the inhibitory activity of the compounds against human immunodeficiency virus type 2 (HIV-2) in MT-4 cells. This method permits the detection in (rabbit) serum samples of dextran sulfate and pentosan polysulfate concentrations as low as 3.0 and 0.5 micrograms/ml, respectively. Pharmacokinetic studies with dextran sulfate and pentosan polysulfate in rabbits indicated that the half-life of these compounds after intravenous bolus injection is approximately 1 h 24 min.
p53 mutations to predict efficacy of alkylating-containing regimen: a metaanalysis of four different clinical trials. (2009)

Abstract Abstract #6064 Background. The predictive value of p53 mutations for efficacy of anthracycline-based chemotherapy is matter of controversy. Inconsistencies among studies could be related to the heterogeneous use of alkylating agents in combination with anthracyclines in different studies. We examined the predictive value of p53 mutations in four different series of breast cancer patients treated with preoperative anthracycline-based chemotherapy including different doses of cyclophosphamide (C).&amp;#x2028; Patients and Methods. All patients had stage II-III breast cancer and received anthracycline-containing chemotherapies. A total of 352 patients were included in four different clinical studies : 65 patients with estrogen receptor (ER)-negative cancers treated with single agent epirubicine (E) (100 mg/m2/3w x 4) in the TOP trial (R1), 52 patients treated with FAC (500 mg/m2 C, 5-FU and 50 mg/m2 doxorubicin/3w x 6) (R2), 96 patients treated with EC-T (75mg/m2 E and 750 mg/m2 C/3w x 4 followed by 100mg/m2 docetaxel/3w x 4) (R3) and 139 patients treated with dose-dense EC (1200mg/m2 C and 75 mg/m2 E/2w x 6) (R4). Before therapy, p53 status was determined in all tumors by yeast functional complementation (FASAY) assay. After chemotherapy, all patients underwent surgery. Pathologic complete response (pCR) was defined as no residual invasive tumour cells in breast and lymph nodes.&amp;#x2028; Results. P53 mutations were more frequently observed in the 128 ER-neg compared to ER-pos cancers (78% vs 29.4%). In p53 mutated tumours, the pCR rate increased with the dose-intensity of C. Conversely, in p53 wild type tumours, pCR rates decreased.&amp;#x2028; &amp;#x2028; Focusing on ER-neg, p53 mutated tumors, the pCR rates rose from 11%, 6%, 32% to 52% in R1, R2, R3 and R4 groups. The R1 and R4 regimen, differing only in C dose intensity, showed marked differences in pCR in ERneg tumors.&amp;#x2028; &amp;#x2028; Conclusions: Increasing doses of C do not seem to improve pCR rates in P53 wild type tumours, raising the possibility of antagonism with anthracycline in this group. On the other hand, in ER-neg, p53 mutant tumors, inclusion of dose-intense C seems to significantly increase pCR rates. Citation Information: Cancer Res 2009;69(2 Suppl):Abstract nr 6064.
Compressive Sensing Based State Estimation for Three Phase Unbalanced Distribution Grid (2017)

Smart metering infrastructure and sensor deployment in the distribution grid is an integral part of the smart grid transition. These smart meters/sensors generate large volumes of data whose aggregation presents a significant challenge from a communication network standpoint. Additionally, the lack of reliability in aggregating this data prevents its use for real time operations such as state estimation and control. In this paper, we propose for the first time, a 2D compressive sensing based strategy to efficiently aggregate power measurements across a three phase unbalanced distribution grid and use it for voltage state estimation. By exploiting the underlying sparsity that results due to spatio temporal correlation of distributed generation and loads, we show that high fidelity estimation of voltage states is feasible even at 50% compression ratios. Using the IEEE 34 node test feeder system as an example, we also demonstrate the impact of the choice of the projection matrix and sparsity basis on reconstruction accuracy.
Is Integer Arithmetic Enough for Deep Learning Training? (2022)

The ever-increasing computational complexity of deep learning models makes their training and deployment difficult on various cloud and edge platforms. Replacing floating-point arithmetic with low-bit integer arithmetic is a promising approach to save energy, memory footprint, and latency of deep learning models. As such, quantization has attracted the attention of researchers in recent years. However, using integer numbers to form a fully functional integer training pipeline including forward pass, back-propagation, and stochastic gradient descent is not studied in detail. Our empirical and mathematical results reveal that integer arithmetic seems to be enough to train deep learning models. Unlike recent proposals, instead of quantization, we directly switch the number representation of computations. Our novel training method forms a fully integer training pipeline that does not change the trajectory of the loss and accuracy compared to floating-point, nor does it need any special hyper-parameter tuning, distribution adjustment, or gradient clipping. Our experimental results show that our proposed method is effective in a wide variety of tasks such as classification (including vision transformers), object detection, and semantic segmentation.
High performance superconducting radio frequency ingot niobium technology for continuous wave applications (2015)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Pashupati Dhakal, Gianluigi Ciovati, Ganapati R. Myneni; High performance superconducting radio frequency ingot niobium technology for continuous wave applications. AIP Conf. Proc. 4 December 2015; 1687 (1): 030002. https://doi.org/10.1063/1.4935323 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
A retrospective cost-effectiveness analysis of the treatment of onychomycosis in general practice (1998)

Analysis of the computer records of 100 general practices from the CompuFile Doctors Independent Network revealed 1492 patients receiving treatment for onychomycosis in the first 6 months of 1994 with terbinafine, tioconazole, amorolfine or griseofulvin. These records indicated the average treatment time for each agent, number of general practitioner consultations and incidence of hospital referrals and minor surgery. Applying standard costs to this resource consumption gave the direct costs for each of these four agents. Published clinical and mycological cure rates allowed a cost per success to be calculated. These were as follows: terbinafine (n = 511) pound258, amorolfine (n = 315) pound312, griseofulvin (n = 196) pound356 and tioconazole (n = 470) pound520. Sensitivity analysis showed that terbinafine remained the most cost-effective option despite variations in resource costs. The cost impact on a typical practice for switching from a less to a more cost-effective treatment is discussed.
Universal Semantic Parsing (2017)

Universal Dependencies (UD) offer a uniform cross-lingual syntactic representation, with the aim of advancing multilingual applications. Recent work shows that semantic parsing can be accomplished by transforming syntactic dependencies to logical forms. However, this work is limited to English, and cannot process dependency graphs, which allow handling complex phenomena such as control. In this work, we introduce UDEPLAMBDA, a semantic interface for UD, which maps natural language to logical forms in an almost language-independent fashion and can process dependency graphs. We perform experiments on question answering against Freebase and provide German and Spanish translations of the WebQuestions and GraphQuestions datasets to facilitate multilingual evaluation. Results show that UDEPLAMBDA outperforms strong baselines across languages and datasets. For English, it achieves a 4.9 F 1 point improvement over the state-of-the-art on Graph-Questions.
Steady-State Somatosensory Evoked Potential for Brain-Computer Interface—Present and Future (2016)

Brain-computer interface (BCI) performance has achieved continued improvement over recent decades, and sensorimotor rhythm-based BCIs that use motor function have been popular subjects of investigation. However, it remains problematic to introduce them to the public market because of their low reliability. As an alternative resolution to this issue, visual-based BCIs that use P300 or steady-state visually evoked potentials (SSVEPs) seem promising; however, the inherent visual fatigue that occurs with these BCIs may be unavoidable. For these reasons, steady-state somatosensory evoked potential (SSSEP) BCIs, which are based on tactile selective attention, have gained increasing attention recently. These may reduce the fatigue induced by visual attention and overcome the low reliability of motor activity. In this literature survey, recent findings on SSSEP and its methodological uses in BCI are reviewed. Further, existing limitations of SSSEP BCI and potential future directions for the technique are discussed.
Phenolic acids as guaiacyl and coumaryl lignins in cell walls of forages and tree leaves. (2000)

The lignins of some range grasses, range legumes and fodder tree leaves present in their cell walls have been oxidised with alkaline nitrobenzene. On degradation guaiacyl Hgnins yielded ferulic acid (FA), while coumaryl lignins yielded o-Coumaric acid (o-CA) and p-Coumaric acids (p-CA.) The forages studied contained these phenolic acids (PA) 8.7-S2.7 mg/g of cell wall at three different stages of growth. Generally, all forage lignins mainly yielded ferulic acid. Range grasses and fodder tree leaves also contained p-CA in high levels while range legumes contained p-CA in lower quantity. The levels of these phenolic acids were correlated (p<0.01) with the lignin content.
Mission enabling and enhancing spacecraft capabilities with microNewton electric propulsion (2010)

The capability to significantly improve current spacecraft pointing, precision orbit maintenance and disturbance mitigation were considered using precision, quiescent microNewton electric propulsion systems. The results of the analyses showed that electric propulsion systems operating in the microNewton to hundreds of microNewtons thrust range can offer significant improvements over state-of-the-art mission capabilities to enable 30 m Earth-fixed orbital tubes, constellation spacecraft position control to within nanometers and exoplanet observatory pointing with 0.1 milliarcsecond precision. Electric propulsion thrust characteristics required to support these capabilities are discussed.
MR Angiography in the Evaluation of Atherosclerotic Peripheral Vascular Disease (2000)

Magnetic resonance (MR) angiography of lower extremity occlusive vascular disease has evolved into a feasible diagnostic imaging option. The previous emphasis on time-of-flight techniques was associated with lengthy acquisition times and artifactual signal losses. Those limitations presented an obstacle to widespread clinical implementation. However, the emergence of rapid imaging sequences combined with gadolinium chelate enhancement offers time-efficient alternatives that can yield a truer representation of the vascular anatomic structure. The technology is now poised to serve as a routine screening study, provided that radiologists understand all factors needed to generate clinically relevant MR angiograms. This article is intended to provide a useful resource directed toward achieving that understanding.
Enhancing Speech Articulation Analysis using a Geometric Transformation of the X-ray Microbeam Dataset (2023)

Accurate analysis of speech articulation is crucial for speech analysis. However, X-Y coordinates of articulators strongly depend on the anatomy of the speakers and the variability of pellet placements, and existing methods for mapping anatomical landmarks in the X-ray Microbeam Dataset (XRMB) fail to capture the entire anatomy of the vocal tract. In this paper, we propose a new geometric transformation that improves the accuracy of these measurements. Our transformation maps anatomical landmarks' X-Y coordinates along the midsagittal plane onto six relative measures: Lip Aperture (LA), Lip Protusion (LP), Tongue Body Constriction Location (TTCL), Degree (TBCD), Tongue Tip Constriction Location (TTCL) and Degree (TTCD). Our novel contribution is the extension of the palate trace towards the inferred anterior pharyngeal line, which improves measurements of tongue body constriction.
Pancreas transplant alone determines early improvement of cardiovascular risk factors and cardiac function in type 1 diabetic patients1 (2003)

PTA with portal drainage induces an early improvement of CRF and ameliorates cardiac function in patients with T1DM.
Extracellular Heme Proteins Influence Bovine Myosatellite Cell Proliferation and the Color of Cell-Based Meat (2019)

Skeletal muscle-tissue engineering can be applied to produce cell-based meat for human consumption, but growth parameters need to be optimized for efficient production and similarity to traditional meat. The addition of heme proteins to plant-based meat alternatives was recently shown to increase meat-like flavor and natural color. To evaluate whether heme proteins also have a positive effect on cell-based meat production, bovine muscle satellite cells (BSCs) were grown in the presence of hemoglobin (Hb) or myoglobin (Mb) for up to nine days in a fibrin hydrogel along 3D-printed anchor-point constructs to generate bioartificial muscles (BAMs). The influence of heme proteins on cell proliferation, tissue development, and tissue color was analyzed. We found that the proliferation and metabolic activity of BSCs was significantly increased when Mb was added, while Hb had no, or a slightly negative, effect. Hb and, in particular, Mb application led to a very similar color of BAMs compared to cooked beef, which was not noticeable in groups without added heme proteins. Taken together, these results indicate a potential benefit of adding Mb to cell culture media for increased proliferation and adding Mb or Hb for the coloration of cell-based meat.
Oncolytic Group B Adenovirus Enadenotucirev Mediates Non-apoptotic Cell Death with Membrane Disruption and Release of Inflammatory Mediators (2016)

Enadenotucirev (EnAd) is a chimeric group B adenovirus isolated by bioselection from a library of adenovirus serotypes. It replicates selectively in and kills a diverse range of carcinoma cells, shows effective anticancer activity in preclinical systems, and is currently undergoing phase I/II clinical trials. EnAd kills cells more quickly than type 5 adenovirus, and speed of cytotoxicity is dose dependent. The EnAd death pathway does not involve p53, is predominantly caspase independent, and appears to involve a rapid fall in cellular ATP. Infected cells show early loss of membrane integrity; increased exposure of calreticulin; extracellular release of ATP, HSP70, and HMGB1; and influx of calcium. The virus also causes an obvious single membrane blister reminiscent of ischemic cell death by oncosis. In human tumor biopsies maintained in ex vivo culture, EnAd mediated release of pro-inflammatory mediators such as TNF-α, IL-6, and HMGB1. In accordance with this, EnAd-infected tumor cells showed potent stimulation of dendritic cells and CD4<sup>+</sup> T cells in a mixed tumor-leukocyte reaction in vitro. Whereas many viruses have evolved for efficient propagation with minimal inflammation, bioselection of EnAd for rapid killing has yielded a virus with a short life cycle that combines potent cytotoxicity with a proinflammatory mechanism of cell death.