gebhart/patrepeval huggingface dataset:
Neural Strokes: Stylized Line Drawing of 3D Shapes (2021)

This paper introduces a model for producing stylized line drawings from 3D shapes. The model takes a 3D shape and a viewpoint as input, and outputs a drawing with textured strokes, with variations in stroke thickness, deformation, and color learned from an artist’s style. The model is fully differentiable. We train its parameters from a single training drawing of another 3D shape. We show that, in contrast to previous image-based methods, the use of a geometric representation of 3D shape and 2D strokes allows the model to transfer important aspects of shape and texture style while preserving contours. Our method outputs the resulting drawing in a vector representation, enabling richer downstream analysis or editing in interactive applications. Our code and dataset are available at our project page: www.github.com/DifanLiu/NeuralStrokes
Epidemiology of Facial Injuries Sustained in Alpine Skiing (1996)

Retrospective studies of alpine skiing injuries show a large shift from the lower part of the body to the upper part; thus injuries to the face have become more frequent. In the years 1991 and 1992, out of 1656 injured patients at the Department of Oral and Maxillofacial Surgery of Innsbruck, 179 were skiers. Of all skiers, 76.5% were between 10 and 40 years of age. Seventy-one patients suffered dentoalveolar trauma (fractures, dislocations, and loss of teeth and periodont). The most exposed bone sustaining a fracture while skiing is the cheekbone. More than half of all accidents were collisions either with other persons or with some obstacle. Of all accidents, 6% took place on lift tracks or at the exit. Of the injured skiers, 24.6% had concomitant injuries, among whom 75% suffered brain injuries.
Activation of Adenovirus Promoters by the Adenovirus E1A Protein in Cell-Free Extracts (1987)

The primary product of the adenovirus E1A gene is a protein that is sufficient for controlling host-cell proliferation and immortalizing primary rodent cells. The mechanism by which the protein induces these cellular effects is poorly understood, but might be linked to its ability to regulate RNA transcription from a number of viral and cellular genes. The mechanism of E1A's transcriptional-activation (trans-activation) was studied here by monitoring the protein's effect on specific adenovirus promoters in two types of transcriptional systems in vitro. One of these systems consisted of extracts from transformed cells constitutively expressing E1A, and the other consisted of extracts of HeLa cells supplemented with a plasmid-encoded E1A protein purified from Escherichia coli. The results show that the E1A protein specifically stimulates transcription from adenovirus promoters; thus, the induction of cellular transcription factors is not necessary to explain the stimulation of transcription by E1A.
Circulating current suppression of converter excited wind power generation system with DC output (2015)

Recently, the research on HVdc transmission from offshore windfarm is attracting many researchers. Additionally, dc output from the wind power generator is expected to have some merits when it is connected to the HVdc transmission system. This paper shows new induction generation system for wind power generation with dc output. The authors propose the system which has the voltage source converter (VSC) exciting induction generator and the PFC converter to absorb the real power in parallel. In this scheme, the circulating current flows between two converters, since the DC side of VSC and PFC converter are connected commonly. The circulating current causes three phase imbalance in ac output and the rating and the cost of VSC increase. Decreasing the circulating current is necessary to have better performance of proposed system. This paper investigated the method of the circulating current reduction by the simulation, analysis and experiment. Then it is shown that shifting the phase of the switching signal of PFC converter. The VSC current is also decreased at the same time and enables cost reduction of the whole system.
Nachweis humaner Papillomavirustypen bei Tumoren und Entzündungen am Auge (1999)

The DNA techniques used in this study represent important methods for the detection of HPV types and allow an association of HPV types with defined tumours and inflammations of the eye. In two of the biopsies putatively new HPV types could be identified.
A built-in self-test high-current LED driver (2009)

In this paper, a built-in self-test (BIST) high-current light-emitting-diode (LED) driver circuit is proposed. The circuit not only maintains different constant currents for multiple LED strings, but it also minimizes the conduction power dissipation by keeping the power MOSFETs in the constant-current controllers operating in the linear region. The proposed driver first acquires the current-voltage (I–V) data of the constant-current power MOSFETs and stores them into memories. These stored I–V data, along with a duty cycle control of the switching converter, are used to ensure that these power MOSFETs are operating in their linear region to minimize conduction power dissipation. The proposed circuit was verified using PSPICE with two to five LED strings. Simulation results show a maximum efficiency of 95.6%.
Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle (2005)

The orbitofrontal cortex (OFC) has been implicated in the representation of emotional stimuli, assignment of emotional valence/salience to stimuli, stimulus-reinforcement association learning, motivation, and socio-emotional control. Using functional magnetic resonance imaging in female subjects without premenstrual mood symptoms, we found that OFC activity to emotional linguistic stimuli varies depending on the menstrual cycle phase. Specifically, anterior-medial OFC activity for negative vs. neutral stimuli was increased premenstrually and decreased postmenstrually. The inverse pattern was seen in the lateral OFC. These findings suggest that specific subregional OFC activity to emotional stimuli is modulated across the menstrual cycle. The data also demonstrate that menstrual cycle phase is an important consideration in further studies attempting to elucidate the neural substrates of affective representation.
A phase Ib, open-label, multicenter study of urelumab (BMS-663513) in combination with rituximab in subjects with relapsed/refractory B-cell malignancies. (2013)

TPS3108 Background: CD137 (4-1BB) is a costimulatory molecule that belongs to the TNF superfamily. It is upregulated on activated lymphocytes, NK cells and dendritic cells and plays an important role in the potentiation of antigen-specific immune responses as well as in antibody-dependent cell-mediated cytotoxicity (ADCC). Urelumab is an agonistic antibody targeting the CD137 receptor. Preclinical evidence has shown that there is modulation of CD137 expression on NK cells after exposure to rituximab. Anti-CD137 agonist monoclonal antibody has been shown to have single-agent anti-lymphoma activity and to potentiate the anti-lymphoma activity of rituximab through enhancing ADCC. We hypothesized that upregulation of CD137 on NK cells by rituximab followed by urelumab could afford a mechanism-based approach to achieve enhanced biologic and/or clinical activity compared to either single agent alone. Here we describe a phase Ib study to investigate the clinical and biologic effects of combined treatment with urelumab and rituximab in patients with relapsed/refractory B-cell malignancies. Methods: This phase I study (n=100) will include dose escalation (Part 1) using a 3+3+3 design and cohort expansion (Part 2). In Part 1, successive cohorts of patients with relapsed/refractory B-NHL will be treated as follows: Cohort 1 (0.1 mg/kg q3weeks) and Cohort 2 (0.3 mg/kg q3weeks) with both cohorts in combination with rituximab 375 mg/m 2 given weekly for the first 4 weeks of each 12 week cycle. In Part 2, cohorts of CLL (n=30), follicular lymphoma (FL) (n=30), and diffuse large B-cell lymphoma (DLBCL) (n=20) will be treated at the dose level found to be safe for the urelumab/rituximab combination. The primary objective of the study is to evaluate the safety and define a safe and effective dose of the urelumab/rituximab combination. Secondary objectives include assessment of the antitumor activity, pharmacokinetics, and immunogenicity. Exploratory objectives include investigation of the immunoregulatory activity of this combination in peripheral blood and paired tumor biopsy specimens and the association of these effects with clinical response/toxicity. Clinical trial information: NCT01775631.
Stereostructure Assignment of Medium-Sized Rings through an NMR−Computational Combined Approach. Application to the New Germacranes Ketopelenolides C and D (2008)

The new germacrane derivatives ketopelenolides C and D have been isolated from great mugwort (Artemisia arborescens). Their stereostructure elucidation exemplifies some of the most common pitfalls facing the configurational assignment of medium-sized polyfunctionalized compounds. It was established through a combined strategy including chemical derivatization, NMR data analysis, molecular modeling, and quantum-mechanical calculations including a comparison between experimental 13C NMR data and a Boltzmann-weighted average of DFT-calculated 13C NMR chemical shifts.
DIAGNOSIS, TREATMENT, AND ANALYSIS OF LONG-TERM OUTCOMES IN IDIOPATHIC NORMAL-PRESSURE HYDROCEPHALUS (2008)

INPH can be diagnosed accurately with CSF pressure monitoring and CSF drainage via a spinal catheter. CSF shunting is safe and effective for INPH with a long-term shunt response rate of 75%. Independent predictors of improvement are the presence of gait impairment as the dominant symptom and shorter duration of symptoms.
Chromosomal position and specific demethylation in enhancer sequences of germ line-transmitted retroviral genomes during mouse development. (1985)

The methylation pattern of the germ line-transmitted Moloney leukemia proviral genome was analyzed in DNA of sperm, of day-12 and day-17 embryos, and of adult mice from six different Mov substrains. At day 12 of gestation, all 50 testable CpG sites in the individual viral genomes as well as sites in flanking host sequences were highly methylated. Some sites were unmethylated in sperm, indicating de novo methylation of unique DNA sequences during normal mouse development. At subsequent stages of development, specific CpG sites which were localized exclusively in the 5' and 3' enhancer regions of the long terminal repeat became progressively demethylated in all six proviruses. The extent of enhancer demethylation, however, was tissue specific and strongly affected by the chromosomal position of the respective proviral genome. This position-dependent demethylation of enhancer sequences was not accompanied by a similar change within the flanking host sequences, which remained virtually unchanged. Our results indicate that viral enhancer sequences, but not other sequences in the M-MuLV genome, may have an intrinsic ability to interact with cellular proteins, which can perturb the interaction of the methylase with DNA. Demethylation of enhancer sequences is not sufficient for gene expression but may be a necessary event which enables the enhancer to respond to developmental signals which ultimately lead to gene activation.
A Fuzzy Random Forest: Fundamental for Design and Construction (2008)

Following Breiman’s methodology, we propose a multi-classifier based on a “forest ” of randomly gener-ated fuzzy decision trees, i.e., a Fuzzy Random Forest. This ap-proach combines the robustness of multi-classifiers, the construction ef-ficiency of decision trees, the power of the randomness to increase the di-versity of the trees in the forest, and the flexibility of fuzzy logic and the fuzzy sets for data managing.
Standardized evaluation and reporting of stent fractures in clinical trials of noncoronary devices (2007)

Abstract Objectives: Define the prospective surveillance and reporting parameters for assessment of metallic stents used in clinical trials of superficial femoral artery atherosclerosis. Background: While advances in medical therapies to improve atherosclerotic risk factor profiles in patients with peripheral arterial disease have focused on prevention of disease progression, the development of endovascular devices is altering the therapeutic algorithm for patients with peripheral arterial disease. Stents have emerged as one of the advances that may promote durable patency, particularly in the infrainguinal arteries. Methods: The Zilver‐PTX is a prospective multicenter randomized trial of bare metal versus drug‐eluting nitinol stents for superficial femoral artery peripheral arterial disease. A predefined surveillance program is mandated in this trial. During the genesis of this program, it became clear that no single standard has existed to identify, classify, and report fractures of metallic stents placed in peripheral arteries. Results: This report defines the key components of prospective stent fracture surveillance, including location of radiographic images obtained, types of radiographic equipment, methods of limb, and image intensifier positioning, intervals required for imaging, grading schemes for reporting, and methods of analyzing the images. Conclusions: As the proliferation of minimally invasive revascularization strategies continues, the stability of metallic endoprostheses is increasingly critical. Uniform surveillance of these devices for fracture and disarticulation is important in order to compare the relative merits of various stent‐based devices in clinical trials. © 2007 Wiley‐Liss, Inc.
Freedom of Acetabular Fragment Rotation Following Three Surgical Techniques for Correction of Congenital Deformities of the Hip (2005)

Femoral head coverage achieved with an acetabular osteotomy for hip dysplasia is achieved by acetabular rotation that can be restricted by osteotomy orientation and soft tissue attachments to the acetabular fragment. Procedures that allow excess rotation or motion in an undesirable direction (especially external rotation) may have undesirable consequences. Rotational aspects of these procedures have not been well described and are not well appreciated radiographically. This study examined the angular motion related to three operative techniques for redirectional acetabular osteotomies. The freedom of motion allowed for the Ganz periacetabular, Carlioz triple, and Tonnis triple osteotomies was quantified using three-dimensional motion measurement. The Ganz osteotomy allowed the greatest amount of motion. The Carlioz osteotomy allowed statistically less motion and depicted the "coupled motion" phenomenon in which a maximal angular rotation in one plane (abduction) is associated with a predicted angular change in another plane (external rotation). The Tonnis osteotomy allowed freedom of motion similar to the Ganz osteotomy without coupled motion.
Pharmacokinetic characterization of 14C-vascular endothelial growth factor controlled release microspheres using a rat model (2002)

The objectives of this study were to characterize the pharmacokinetics of vascular endothelial growth factor (VEGF) in poly(lactic-co-glycolic) acid (PLGA) microspheres using a rat model, and to develop a pharmacokinetic model for this controlled release formulation. 14C-VEGF was encapsulated using a solid-in-oil-in-water emulsification method. The microspheres were administered subcutaneously to rats and the pharmacokinetic parameters were compared with those of protein solutions. Intravenous administration of protein solutions resulted in short half-lives and subcutaneous administration resulted in rapid clearance from the subcutaneous tissue, with high plasma concentrations as expressed by rapid absorption and elimination. The subcutaneous administration of the VEGF microspheres produced low plasma concentrations and high subcutaneous concentrations over a period of 7 weeks. The area under the curve (AUC), the time required to achieve the maximum concentration (tmax), the maximum concentration (Cmax) in blood samples and the elimination rate constant (kel) values at the subcutaneous tissue site were selected to compare the pharmacokinetic characterization of VEGF microspheres with that of protein solutions. The in-vivo release profiles of the proteins were slower than the in-vitro release profiles and they followed the same trend as the in-vitro and in-vivo PLGA degradation rates. The PLGA microsphere degradation was the determinant step for VEGF release from the microspheres and its absorption at the subcutaneous site. Microspheres appear to be an attractive system for the localized rate-controlled delivery of VEGF. 14C-Methylation via reductive alkylation of VEGF did not affect its mitogenic activity, however approximately 25% activity was lost following release from PLGA microspheres. This loss of activity may be due to degradation in an acidic environment as a result of PLGA degradation.
Technology Portfolio Planning by Weighted Graph Analysis of System Architectures (2014)

ABSTRACT Many systems undergo significant architecture‐level change throughout their lifecycles in order to adapt to new operating and funding contexts, to react to failed technology development, or to incorporate new technologies. In all cases early architecture selection and technology investment decisions will constrain the system to certain regions of the tradespace, which can limit the evolvability of the system and its robustness to exogenous changes. In this paper we present a method for charting development pathways within a tradespace of potential architectures, with a view to enabling robustness to technology portfolio realization and later architectural changes. The tradespace is first transformed into a weighted, directed graph of architecture nodes with connectivity determined by relationships between technology portfolios and functional architecture. The tradespace exploration problem is then restated as a shortest path problem through this graph. This method is applied to the tradespace of in‐space transportation architectures for missions to Mars, finding that knowledge of pathways through the tradespace can identify negative coupling between functional architectures and particular technologies, as well as identify ways to prioritize future technology investments.
Differential effects of emotional valence on mnemonic performance with greater hippocampal maturity (2023)

The hippocampal formation (HF) facilitates declarative memory, with subfields providing unique contributions to memory performance. Maturational differences across subfields facilitate a shift toward increased memory specificity, with peripuberty sitting at the inflection point. Peripuberty is also a sensitive period in the development of anxiety disorders. We believe HF development during puberty is critical to negative overgeneralization, a common feature of anxiety disorders. To investigate this claim, we examined the relationship between mnemonic generalization and a cross-sectional pubertal maturity index (PMI) derived from partial least squares correlation (PLSC) analyses of subfield volumes and structural connectivity from T1-weighted and diffusion-weighted scans, respectively. Participants aged 9-14 yr, from clinical and community sources, performed a recognition task with emotionally valent (positive, negative, and neutral) images. HF volumetric PMI was positively associated with generalization for negative images. Hippocampal-medial prefrontal cortex connectivity PMI evidenced a behavioral relationship similar to that of the HF volumetric approach. These findings reflect a novel developmentally related balance between generalization behavior supported by the hippocampus and its connections with other regions, with maturational differences in this balance potentially contributing to negative overgeneralization during peripuberty.
Synthèse d'un filtre DLD Hinf/H-; Equivalence avec un observateur (2002)

International audience
Shaped-Beam Reflectarray Antenna Optimized at Multiple Frequency (2021)

In previous research, only the center frequency was optimized when designing a reflectarray antenna that radiates a shaped beam. In this study, we designed a shaped beam reflectarray antenna by optimizing the center frequency as well as multiple frequencies, in addition to using the conventional design method.
Antenna coupled Kinetic Inductance arrays for space and ground based imaging arrays (2009)

Very large arrays of Microwave Kinetic Inductance Detectors (MKIDs) have the potential to revolutionize ground and space based astronomy. They can offer in excess of 10000 pixels with large dynamic range and very high sensitivity in combination with very efficient frequency division multiplexing at GHz frequencies. In this paper we present the development for a ∼100 pixel MKID demonstration array based upon an single pixel consisting of an integrated MKID‐antenna detector, with the antenna placed in the second focus of an elliptical Si lens. The design presented can be scaled to any frequency between 80 GHz and >5 THz because there is no need for superconducting structures that become lossy at frequencies above the gap frequency of the materials used. We present measurements of the optical coupling efficiency, sensitivity and discuss array development. We have obtained a dark sensitivity of 7×10−19W/Hz1/2 using 100 nm thick A1 devices and an optical coupling efficiency of 35% referring to the power of a single polarization optical signal in front of the Si lens of the detector.
Education of the mucosal immune system: the role of breast milk during bacterial colonisation of the neonatal intestine. (2006)

The aim of the present study was to assess the efficacy and safety of olanzapine in the treatment of schizophrenic patients. 27 patients were randomly assigned to treatment with olanzapine or haloperidol over 12 weeks. The primary efficacy measure was the mean change from baseline to endpoint in total scores on the Brief Psychiatric Rating Scale (BPRS) and assessing treatment emergent adverse events. Secondary measures were positive symptoms, negative symptoms, general psychopathology depression, anxiety and quality of life. Compared to haloperidol, olanzapine had equal effect in improving overall psychopathology, positive symptoms, and severity of schizophrenic illness. Olanzapine showed supehor improvement on negative symptoms and secondary depressive features. Commonest side effects were weight gain, sleepiness and increased duration of sleep. Olanzapine is effective in improving overall psychopathology including positive symptoms, negative and secondary depressive features in Indian patients with schizophrenia and it is safe and well tolerated at dosage between 5 to 20 mg/day.
Kognitive Dissonanz (2019)

Der kleine Gehirnversteher reißt die Sprachbarriere ein, die die Hirnforschung zwischen uns und unserem Gehirn errichtet hat. Jedes der fünfunddreißig kurzen, erhellenden und unterhaltsamen Kapitel erklärt einen grundlegenden Begriff der Hirnforschung anhand einer ungewöhnlichen Geschichte. Leicht zu lesen, vollständig und extrem lehrreich: das erste Buch, das den Leser zum Gehirnversteher macht.