gebhart/patrepeval huggingface dataset:
Robust UAV Search for Environments with Imprecise Probability Maps (2006)

This paper introduces a new framework for UAV search operations and proposes a new approach to calculate the minimum number of looks needed to achieve a given level of confidence of target existence in an uncertain gridded environment. Typical search theory formulations describe the uncertainty in the environment in a probabilistic fashion, by assigning probabilities of target existence to the individual cells of the grid. While assumed to be precisely known in the search theory literature, these probabilities are often the result of prior information and intelligence, and will likely be poorly known. The approach taken in this paper models this imprecise knowledge of the prior probabilities in the individual cells using the Beta distribution and generates search actions that are robust to the uncertainty. Use of the Beta distribution leads to an analytical prediction of the number of looks in a particular cell that would be needed to achieve a specified threshold in the confidence of target existence. The analytical results are demonstrated in both an expected value setting and a framework that takes into account the variance of the posterior distribution. The effectiveness of the proposed framework is demonstrated in several numerical simulations.
Sympathomimetic amines having a 3,4-dihydrocarbostyril nucleus. (1978)

A series of new sympathomimetic amines having a 3, 4-dihydrocarbostyril nucleus was synthesized. These compounds have two weakly acidic hydrogen atoms in locations similar to those of the hydroxyl groups of adrenergic agents containing catechol. One threo-isomer 1i-threo was synthesized by inversion of the corresponding erythro-isomer by the SNi reaction.
Spectacle side panels and moist inserts for the treatment of dry-eye patients (1995)

To increase the moisture level around the eyes, small, wet, acute, triangular sponges, from which water steadily evaporates, were attached to special side panels of modified eyeglasses. The moisture level in the region between the cornea and the spectacle lens was measured in 10 patients with moderately severe dry eyes and in 10 normal controls, by a miniature moisture sensor under ambient conditions of 22.3 degrees C and 29.8% humidity. The humidity was 32.0 +/- 4.2% with spectacles, frame only (no lenses); 32.3 +/- 6.0% with spectacles; 37.9 +/- 5.1% with spectacles equipped with side panels, and 42.7 +/- 5.7% with side panel moist inserts attached for dry eye patients. Humidity was the highest with moist inserts added to the spectacles of the control group, with or without moderate wind. All dry eye patients noticed symptomatic relief with the inserts, and the rose bengal score and fluorescein staining improved after 2 weeks of their use. Our findings indicate that the combination of side panels and periodically moistened sponge inserts offer a simple and noninvasive approach to increasing the humidity surrounding the eyes, thus decreasing the tear evaporation from the ocular surface and providing amelioration of frequently debilitating symptoms of dry eye.
Rheological Properties of Starch and Whey Protein Isolate Gels (2007)

The paste viscosity of starches Amioca (~0.5% amylose), native corn (~27% amylose), Hylon VII (~70% amylose), tapioca (~19% amylose), and their whey protein isolate (WPI; 50/50) mixtures at varying solid concentration of 2.5, 5, 10, 15 and 20% were determined. At higher gel concentration (20%) during the cooling cycle, WPI paste measured by rapid visco-analyser (RVA) showed a tremendous increase in viscosity over that of the micro visco-amylograph (MVA), 5784 and 184 cP, respectively. RVA gels had a more uniform network of coarse particles (~250—500 nm) than the fine structures (~50 nm) in those of the MVA. Inclusion of WPI reduced the paste viscosity of all starches by at least 50%, except for Hylon VII at 20% solid concentration. The strength of Hylon VII and corn starch gels was reduced by WPI. In contrast, gels of WPI/tapioca ( G' = 45.4 Pa) and WPI/amioca ( G' = 18.3 Pa) had similar rheological properties as their pure starch control ( G' = 47.4 Pa and G' = 15.3 Pa for Tapioca and Amioca, respectively).
Noninvasive Medical Diagnostics & Treatment Using Ultrasonics (1998)

In parallel to the industrial application of NDE to flaw detection and material property determination, the medical community has succesfully adapted such methods to the noninvasaive diagnostics and treatment of many conditions and disorders of the human body.
In-situ synchrotron x-ray diffraction and thermal expansion of TiB2 up to ∼3050 °C (2023)

There is an increasing interest in understanding the performance and properties of ultra-high temperature ceramics due to their high melting points (<3000 °C) that make them promising for extreme environment applications. In-situ high temperature X-ray diffraction experiments were performed on TiB2 beads up to ∼3050 °C. For these experiments, TiB2 powders were fabricated into spherical beads via gel casting methods and densified in a high temperature graphite furnace. These sample beads were then levitated in a conical nozzle levitator with reducing atmosphere (3% H2 -Ar) while being heated using a 400 W CO2 laser. During levitation a collimated synchrotron X-ray source was used to perform in-situ, temperature-dependent structural characterizations. The anisotropic coefficients of thermal expansion of TiB2 were characterized as a function of temperature up to ∼3050 °C. Elucidation of these properties are critical for the advancement of TiB2 ceramics and other transition metal di-borides for use in high temperature applications such as hypersonic platforms, nuclear reactors, and atmospheric re-entry.
Redox modulation of peripheral T-type Ca2+ channels in vivo: alteration of nerve injury-induced thermal hyperalgesia (2004)

We reported recently that redox agents, including the endogenous amino acid L-cysteine, modulate T-type Ca2+ currents in primary sensory neurons in vitro, and alter mechanical and thermal nociception in peripheral nociceptors in vivo in intact animals [Neuron 31 (2001) 75]. Here, we studied the effects of locally applied redox agents (L-cysteine and 5,5'-dithio-bis-(2-nitrobenzoic acid) (DTNB) on thermal hyperalgesia in animals with neuropathic pain due to chronic constrictive injury (CCI) of the sciatic nerve. We found that, following injection into the peripheral receptive fields, the endogenous reducing agent L-cysteine increased thermal hyperalgesia in a dose-dependent manner in rats with CCI of the sciatic nerve as well as in sham-operated rats. However, the magnitude of the increase was smaller and duration of effect was shorter in rats with CCI of the sciatic nerve compared to sham-operated animals. DTNB, an exogenous oxidizing agent, induced dose-dependent alleviation of thermal hyperalgesia in rats with CCI of the sciatic nerve and caused analgesia in sham-operated rats. DTNB completely blocked L-cysteine-induced thermal hyperalgesia in both animal groups. Mibefradil, a potent and preferential T-type Ca2+ channel blocker, abolished L-cysteine-induced increase in thermal hyperalgesia in both animal groups suggesting the involvement of T-type Ca2+ channels in peripheral nociception. These results indicate for the first time that redox modulation of T-type Ca2+ channels in rat peripheral nociceptors is operational in pain states caused by peripheral axonal injury. Since thermal hyperalgesia is a common symptom of axonal injury, locally applied oxidizing agents could be used as a novel treatment to ameliorate neuropathic pain.
Clinical Characteristics and Prognostic Implications of NPM1 Mutations in Acute Myeloid Leukemia. (2005)

Abstract Nucleophosmin (NPM) is a nucleolar protein with multi-functions including centromere duplication, nuclear-cytoplasmic shuttling, ribosomal biogenesis, p53 stability. NPM1 mutations were found in a large number of patients with acute myeloid leukemia (AML) especially with normal karyotype. The mutations lead to the aberrant subcellular localization of NPM protein. However, their impacts on clinical outcome remain controversial. We screened the mutations of NPM1 in 257 AML patients and analyzed the clinical significance. NPM1 mutations were found in 64 of 257 patients (24.9%). Seven types of mutations, including four novel mutations, were identified. NPM1 mutations were associated with normal karyotype, FLT3 mutations (both FLT3-ITD and D835 mutation) but not with other gene alterations such as N-RAS, p53 mutations and partial tandem duplication of the MLL gene. In 190 patients except the M3 subgroup, who were treated according to the protocol of Japan Adult Leukemia Study Group, the multivariate analysis revealed that NPM1 mutation was a favorable factor for achieving complete remission, but significantly associated with relapse. A sequential analysis, using paired samples obtained at diagnosis and relapse in 39 patients, revealed that NPM1 mutations were lost at relapse in 2 of the seventeen patients who had NPM1 mutations at diagnosis and none of the patients, who did not have NPM1 mutations at diagnosis, gained NPM1 mutations at relapse. Our results suggest that NPM-mutated AML should be a distinct subgroup with specific clinical characteristics and outcome. Loss of NPM mutations at relapse implies that NPM mutation is not necessarily a primary genetic alteration and that these leukemic clones could be sensitive to chemotherapy.
ChemInform Abstract: Hydrothermal Synthesis of Zeolites (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The myogenic regulatory factors, determinants of muscle development, cell identity and regeneration (2017)

The Myogenic Regulatory Factors (MRFs) Myf5, MyoD, myogenin and MRF4 are members of the basic helix-loop-helix family of transcription factors that control the determination and differentiation of skeletal muscle cells during embryogenesis and postnatal myogenesis. The dynamics of their temporal and spatial expression as well as their biochemical properties have allowed the identification of a precise and hierarchical relationship between the four MRFs. This relationship establishes the myogenic lineage as well as the maintenance of the terminal myogenic phenotype. The application of genome-wide technologies has provided important new information as to how the MRFs function to activate muscle gene expression. Application of combined functional genomics technologies along with single cell lineage tracing strategies will allow a deeper understanding of the mechanisms mediating myogenic determination, cell differentiation and muscle regeneration.
Lamb-dip saturated-absorption cavity ring-down rovibrational molecular spectroscopy in the near-infrared (2022)

The high-detection-sensitivity saturated-absorption cavity ring-down (SCAR) technique is extended to Lamb-dip spectroscopy of rovibrational molecular transitions in the near-infrared region. Frequency-comb-referenced sub-Doppler saturation measurements, performed on the acetylene <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="m1"> <mml:mo stretchy="false">(</mml:mo> <mml:msub> <mml:mi>ν</mml:mi> <mml:mn>1</mml:mn> </mml:msub> <mml:mo>+</mml:mo> <mml:msub> <mml:mi>ν</mml:mi> <mml:mn>3</mml:mn> </mml:msub> <mml:mo>+</mml:mo> <mml:msub> <mml:mi>ν</mml:mi> <mml:mn>4</mml:mn> </mml:msub> <mml:mo>←</mml:mo> <mml:msub> <mml:mi>ν</mml:mi> <mml:mn>4</mml:mn> </mml:msub> <mml:mo stretchy="false">)</mml:mo> </mml:math> R(14)e line at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="m2"> <mml:mrow> <mml:mn>6562</mml:mn> <mml:mtext> </mml:mtext> <mml:msup> <mml:mrow> <mml:mi>cm</mml:mi> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>1</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> , are analyzed by a SCAR global line profile fitting routine, based on a specially developed theoretical model. Compared to a conventional cavity ring-down evaluation, our approach yields dip profiles with a linewidth freed from saturation broadening effects, reduced by 40%, and a signal-to-noise ratio increased by 90%. Ultimately, an overall (statistical and systematic) fractional uncertainty as low as <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline" id="m3"> <mml:mrow> <mml:mn>7</mml:mn> <mml:mo>×</mml:mo> <mml:msup> <mml:mrow> <mml:mn>10</mml:mn> </mml:mrow> <mml:mrow> <mml:mo>−</mml:mo> <mml:mn>12</mml:mn> </mml:mrow> </mml:msup> </mml:mrow> </mml:math> is achieved for the absolute line-center frequency. At the same time, our method is also able to accurately infer the linear (non-saturated) behavior of the gas absorption, providing Lamb-dip-based line strength measurements with a relative uncertainty of 0.5%.
Ceramide Content Is Increased in Skeletal Muscle From Obese Insulin-Resistant Humans (2004)

Increased intramyocellular lipid concentrations are thought to play a role in insulin resistance, but the precise nature of the lipid species that produce insulin resistance in human muscle are unknown. Ceramides, either generated via activation of sphingomyelinase or produced by de novo synthesis, induce insulin resistance in cultured cells by inhibitory effects on insulin signaling. The present study was undertaken to determine whether ceramides or other sphingolipids are increased in muscle from obese insulin-resistant subjects and to assess whether ceramide plays a role in the insulin resistance of Akt in human muscle. Lean insulin-sensitive and obese insulin-resistant subjects (n = 10 each) received euglycemic-hyperinsulinemic clamps with muscle biopsies basally and after 30, 45, or 60 min of insulin infusion. The rate of glucose infusion required to maintain euglycemia (reflecting glucose uptake) was reduced by >50%, as expected, in the obese subjects at each time point (P < 0.01). Under basal conditions, total muscle ceramide content was increased nearly twofold in the obese subjects (46 +/- 9 vs. 25 +/- 2 pmol/2 mg muscle, P < 0.05). All species of ceramides were increased similarly in the obese subjects; in contrast, no other sphingolipid was increased. Stimulation of Akt phosphorylation by insulin in the obese subjects was significantly reduced after 30 min (0.96 +/- 0.11 vs. 1.84 +/- 0.38 arbitrary units) or 45-60 min (0.68 +/- 0.17 vs. 1.52 +/- 0.26) of insulin infusion (P < 0.05 for both). Muscle ceramide content was significantly correlated with the plasma free fatty acid concentration (r = 0.51, P < 0.05). We conclude that obesity is associated with increased intramyocellular ceramide content. This twofold increase in ceramide may be involved in the decrease in Akt phosphorylation observed after insulin infusion and could theoretically play a role in the reduced ability of insulin to stimulate glucose uptake in skeletal muscle from obese subjects.
Data from Randomized, Double-Blind, Placebo-Controlled Phase III Study of Paclitaxel ± Napabucasin in Pretreated Advanced Gastric or Gastroesophageal Junction Adenocarcinoma (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;To compare napabucasin (generator of reactive oxygen species) plus paclitaxel with paclitaxel only in patients with second-line advanced gastric or gastroesophageal junction (GEJ) adenocarcinoma.&lt;/p&gt;Patients and Methods:&lt;p&gt;In the double-blind, phase III BRIGHTER study (NCT02178956), patients were randomized (1:1) to napabucasin (480 mg orally twice daily) plus paclitaxel (80 mg/m&lt;sup&gt;2&lt;/sup&gt; i.v. weekly for 3 of 4 weeks) or placebo plus paclitaxel. The primary endpoint was overall survival (OS). Secondary endpoints included progression-free survival (PFS), objective response rate (ORR), disease control rate (DCR), and safety.&lt;/p&gt;Results:&lt;p&gt;Overall, 714 patients were randomized (napabucasin plus paclitaxel, &lt;i&gt;n&lt;/i&gt; = 357; placebo plus paclitaxel, &lt;i&gt;n&lt;/i&gt; = 357). 72.1% were male, 74.6% had gastric adenocarcinoma, and 46.2% had peritoneal metastases. The study was unblinded following an interim analysis at 380 deaths. The final efficacy analysis was performed on 565 deaths (median follow-up, 6.8 months). No significant differences were observed between napabucasin plus paclitaxel and placebo plus paclitaxel for OS (6.93 vs. 7.36 months), PFS (3.55 vs. 3.68 months), ORR (16% vs. 18%), or DCR (55% vs. 58%). Grade ≥3 adverse events occurred in 69.5% and 59.7% of patients administered napabucasin plus paclitaxel and placebo plus paclitaxel, respectively, with grade ≥3 diarrhea reported in 16.2% and 1.4%, respectively.&lt;/p&gt;Conclusions:&lt;p&gt;Adding napabucasin to paclitaxel did not improve survival in patients with pretreated advanced gastric or GEJ adenocarcinoma. Consistent with previous reports, the safety profile of napabucasin was driven by manageable gastrointestinal events; grade ≥3 diarrhea occurred at a higher frequency with napabucasin plus paclitaxel versus placebo plus paclitaxel.&lt;/p&gt;&lt;/div&gt;
NMR identification of protein surfaces using paramagnetic probes (1990)

Paramagnetic agents produce line broadening and thus cancellation of anti phase cross-peak components in two-dimensional correlated nuclear magnetic resonance spectra. The specificity of this effect was examined to determine its utility for identifying surface residues of proteins. Ubiquitin and hen egg white lysozyme, for which X-ray crystal structures and proton NMR assignments are available, served as test cases. Two relaxation reagents were employed, 4-hydroxy-2,2,6,6-tetramethylpiperidinyl-1-oxy and the gadolinium (III) diethylenetriaminepentaacetate complex ion. Correlations were sought between reagent-produced decreases of side-chain cross-peak volumes in double-quantum-filtered proton correlation (DQF-COSY) spectra and the solvent-exposed side-chain surface area of the corresponding residues. The lanthanide complex produced strong effects ascribable to association with carboxylate groups but was not otherwise useful in delineating surface residues. The nitroxyl, on the other hand, produced clear distinctions among the Val, Leu, and Ile residues that generally paralleled side-chain exposure in the crystal, although consistent correlations were not observed with residues of other types. Although an instance of possible specific protein-nitroxyl association was noted, the nitroxyl appears to be a tool for identifying hydrophobic surface residues.
Allosteric Effects Govern Nuclear Receptor Action: DNA Appears as a Player (2009)

Nuclear receptors (NRs) are a family of transcription factors that regulate cognate gene networks, resulting in profound physiological and pathophysiological changes. Dysfunctional NR signaling leads to proliferative, reproductive, and metabolic diseases such as cancer, infertility, obesity, or diabetes. Indeed, NR-based pharmaceuticals are among the most commonly used drugs. NRs function by communicating with the intracellular and extracellular environment, thereby both sensing and modulating the status of cells. They respond to incoming signals by orchestrating transcriptional as well as nongenomic effects. They do so through an ability to respond to various effectors, such as the cognate ligand, by allosteric structural alterations that are the basis of further signal propagation. A mechanism has now been revealed by which DNA could act as an allosteric effector to modulate glucocorticoid receptor activity. This is a new regulatory paradigm for NR action that may help to explain how a receptor fine-tunes its target gene network.
Inducible Nitric Oxide Synthase Inhibitors of Chinese Herbs III.<i>Rheum palmatum</i> (2002)

In this paper, the effects of bioactive compounds of Rheum palmatum L. on the inhibition of NO production from RAW 264.7 cells were explored. Seven main anthraquinone derivatives were isolated from the root of R. palmatum, and of these, emodin and rhein significantly inhibited nitrite production from lipopolysaccharide (LPS)-activated RAW 264.7 cells. The IC(50) values for inhibition of nitrite production by emodin and rhein were 60.7 and 67.3 microM, respectively. After iNOS enzyme activity was stimulated by LPS for 12 h, treatment with emodin or rhein at 20 microg/ml for 18 h did not significantly inhibit NO production. The data show that the inhibitory activity of emodin and rhein is not due to direct inhibition of iNOS enzyme activity. However, expression of iNOS and the COX-2 protein was inhibited by emodin in LPS-activated RAW 264.7 cells, and PGE(2) production was reduced. Rhein also inhibited LPS-induced iNOS protein expression, but not COX-2 or PGE(2) production. On the other hand, inhibition effects on NO production from RAW 264.7 cells were enhanced and cytotoxic effects decreased by co-treatment with emodin and rhein. In conclusion, emodin and rhein are major iNOS inhibitors of R. palmatum and may possibly serve as bioactive substances for anti-inflammation effects.
Long-period fiber grating by electrical discharge (2002)

Long-period gratings were manufactured by applying step by step an electric discharge through a standard telecommunication fibre. The induced perturbation was so large that less than 20 steps are necessary to obtain a coupling length.
Towards the Syntheses of N—H and N‐Alkylated Derivatives of Meridianins. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Asymmetric Hydrogenation of Quinolines Catalyzed by Iridium Complexes of Monodentate BINOL‐Derived Phosphoramidites (2008)

Abstract The monodentate BINOL‐derived phosphoramidite PipPhos is used as ligand for the iridium‐catalyzed asymmetric hydrogenation of 2‐ and 2,6‐substituted quinolines. If tri‐ ortho ‐tolylphosphine and/or chloride salts are used as additives enantioselectivities are strongly enhanced up to 89%. NMR indicates that no mixed complexes are formed upon addition of tri‐ ortho ‐tolylphosphine.
Cardiovascular Protective Effects of NP-6A4, a Drug with the FDA Designation for Pediatric Cardiomyopathy, in Female Rats with Obesity and Pre-Diabetes (2023)

Cardiac autophagy impairment underlies heart disease induced by obesity and pre-diabetes, and there are no drugs to re-activate autophagy. We propose that NP-6A4 can be an effective drug to reactivate cardiac autophagy and treat obesity- and pre-diabetes-induced heart disease, particularly for young and obese women.
Fusing ultra-wideband radar and lidar for small UGV navigation in all-weather conditions (2010)

Autonomous small UGVs have the potential to greatly increase force multiplication capabilities for infantry units. In order for these UGVs to be useful on the battlefield, they must be able to operate under all-weather conditions. For the Daredevil Project, we have explored the use of ultra-wideband (UWB) radar, LIDAR, and stereo vision for all-weather navigation capabilities. UWB radar provides the capability to see through rain, snow, smoke, and fog. LIDAR and stereo vision provide greater accuracy and resolution in clear weather but has difficulty with precipitation and obscurants. We investigate the ways in which the sensor data from UWB radar, LIDAR, and stereo vision can be combined to provide improved performance over the use of a single sensor modality. Our research includes both traditional sensor fusion, where data from multiple sensors is combined in a single representation, and behavior-based sensor fusion, where the data from one sensor is used to activate and deactivate behaviors using other sensor modalities. We use traditional sensor fusion to combine LIDAR and stereo vision for improved obstacle avoidance in clear air, and we use behavior-based sensor fusion to select between radar-based and LIDAR/vision-based obstacle avoidance based on current environmental conditions.