gebhart/patrepeval huggingface dataset:
Homologous NRPS‐like Gene Clusters Mediate Redundant Small‐Molecule Biosynthesis in <i>Aspergillus flavus</i> (2012)

Biosynthetic crosstalk: Most gene clusters in fungi are orphans with no known associated metabolites. NMR-based comparative metabolomics was used to identify the products of two highly homologous orphan clusters in Aspergillus flavus. The two clusters encode partially redundant biosynthetic pathways that produce overlapping sets of novel fungal alkaloids, feature NRPS-like genes with unusual functions, and regulate fungal development. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Effect of reducing acid etching time on bond strength to noncarious and caries-affected primary and permanent dentin. (2013)

For Prime & Bond NT, the etching of dentin for five seconds could be recommended for primary teeth, while 10 seconds would be the minimum time for permanent teeth.
10-Mode-Multiplexed Transmitter Employing 2-D VCSEL Matrix (2021)

A mode-multiplexed transmitter combining a 2-D VCSEL matrix on a Si interposer and a multi-plane light converter is demonstrated. This enables 200-Gb/s transmission using 10G-class VCSELs over 100-m multimode fiber with direct detection and 28-km few-mode fiber with coherent detection.
In &lt;em&gt;Vitro&lt;/em&gt; and In&lt;em&gt; Vivo&lt;/em&gt; Efficacy of a Stroma Targeted, Tumor Microenvironment Responsive Oncolytic Adenovirus in Different Preclinical Models of Cancer (2023)

More than 1 million women are diagnosed annually worldwide with a gynecological cancer. Most gynecological cancers are diagnosed at late stage, either because lack of symptoms such as in ovarian cancer or limited accessibility to primary prevention in low-resource countries such as in cervical cancer. Here, we extend the studies of AR2011, a stroma-targeted and tumor microenvironment responsive oncolytic adenovirus (OAdV) whose replication is driven by a triple hybrid promoter. We show that AR2011 was able to replicate and lyse in vitro fresh explants obtained from human ovarian cancer. uterine cancer, and cervical cancer. AR2011 was also able to strongly inhibit the in vitro growth of ovarian malignant cells obtained from human ascites fluid. The virus could synergize in vitro with cisplatin even on ascites-derived cells obtained from patients heavily pretreated with neoadjuvant chemotherapy. AR2011(h404) a dual transcriptionally targeted derived virus armed with hCD40L and h41BBL under the regulation of the hTERT promoter, showed a strong efficacy in vivo both on subcutaneous and intraperitoneally established human ovarian cancer in nude mice. Preliminary studies in an immunocompetent murine tumor model showed that AR2011(m404) expressing the murine cytokines was able to induce an abscopal effect. The present studies suggest that AR2011(h404) is a likely candidate as a novel medicine for intraperitoneal disseminated ovarian cancer.
&lt;title&gt;Optical communication systems for satellite applications&lt;/title&gt; (1999)

In conventional satellites, the RF and microwave signal transmissions between electronic modules are accomplished using waveguide or coaxial lines. Advances in fiber-optic technology have made it possible to modulate low-noise RF and microwave signal on fiber-optic distribution lines, resulting in weight and space savings. These optical communication systems enable intrasatellite communications among the electronic modules like transmitters, receivers, and clocks. This paper summarizes findings from several studies on the use of fiber-optic lines for RF/microwave signal transmission on-board satellites. It will also update some experimental results of prototype systems developed previously for intrasatellite signal distribution.
Start–Stop Cyclic Durability Analysis of Membrane–Electrode Assemblies Using Polyflourene-Based Electrolytes for an Anion-Exchange Membrane Water Electrolyzer (2023)

Highly durable anion-exchange membranes and ionomers are essential for developing cost-effective green hydrogen generation. The anion-exchange membrane and ionomer must withstand chemical attacks by OH– ions as well as nonlinear mechanical stress caused by irregular bubble formation when the electrolyzer is coupled with intermittent power sources. Herein, we examined the durability of a trimethylammonium-modified poly(fluorene-alt-tetrafluorophenylene) (PFT-C10-TMA)-based membrane and ionomer under dynamic operation to evaluate its competency to couple with intermittent power sources. The durability of membrane–electrode assembly (MEA) prepared using these polymer membrane and ionomer was evaluated by performing 1000 start–stop voltage cycles in 1 M KOH solution at 80 °C while varying the applied cell voltage. The electrochemical performances of the MEA and electrodes were simultaneously evaluated using an electrolyzer with reference electrodes, and the chemical structure of the polymer was examined before and after the durability test using NMR techniques. The MEA based on a commercial Sustainion XB-7 ionomer and X37-50 RT anion-exchange membranes showed the catalyst leaching during start–stop cycles, resulting in reduced cell performance. On the other hand, the MEAs with the PFT-C10-TMA membrane and ionomer demonstrated promising high chemical and mechanical durability under dynamic start–stop operation, encouraging the development of electrolyzers that can function with intermittent renewable power sources.
A Novel <i>COL1A1-CAMTA1</i> Rearrangement in Cranial Fasciitis (2020)

Cranial fasciitis is an uncommon benign fibroblastic tumor, generally histologically identical to nodular fasciitis. It develops almost exclusively in children. Cranial fasciitis manifests clinically as a painless rapidly growing solitary nodule in the head and neck area, frequently eroding the underlying bone. Thus, this entity is often confused with aggressive lesions such as sarcomas, both clinically and radiologically. Histopathologic examination is essential to differentiate between cranial fasciitis and fibrohistiocytic or even sarcomatous lesions observed in children. In this article, we present a case of cranial fasciitis with intracranial extension in a 2-year-old boy. Although <i>USP6</i> rearrangement has recently been recognized as a recurring alteration in nodular fasciitis, we present a novel <i>COL1A1-CAMTA1</i> fusion in this lesion.
Hydrogen passivation of dislocations in InP on GaAs heterostructures (1994)

The effects of hydrogenation on the properties of Zn-doped InP/GaAs heterostructures grown by metalorganic chemical vapor deposition were studied by current-voltage (I-V), deep level transient spectroscopy (DLTS), and photoluminescence. Significant improvements in leakage current and breakdown voltage in InP diodes on GaAs were observed after a 2 h hydrogen plasma exposure at 250 °C. DLTS indicated a corresponding reduction in total trap concentration from ∼6×1014 to ∼3×1012 cm−3 at a depth of ∼1.5 μm below the surface. The Zn dopants were completely reactivated by a subsequent 5 min 400 °C anneal without degradation of the reverse current or reactivation of the deep levels. Anneals in excess of 580 °C were necessary to reactivate the deep levels and degrade the leakage current to their original values, indicating the passivation of threading dislocations by hydrogen, and the existence of a wide temperature window for post-passivation processing.
TU-CD-207-08: Intrinsic Image Quality Comparison of Synthesized 2-D and FFDM Images (2015)

Purpose: With the combined interest of managing patient dose, maintaining or improving image quality, and maintaining or improving the diagnostic utility of mammographic data, this study aims to compare the intrinsic image quality of Hologic's synthesized 2-D (C-View) and 2-D FFDM images in terms of resolution, contrast, and noise. Methods: This study utilized a novel 3-D printed anthropomorphic breast phantom in addition to the American College of Radiology (ACR) mammography accreditation phantom. Analysis of the 3-D anthropomorphic phantom included visual assessment of resolution and analysis of the normalized noise power spectrum. Analysis of the ACR phantom included both visual inspection and objective automated analysis using in-house software. The software incorporates image- and object-specific CNR visibility thresholds which account for image characteristics such as noise texture which affect object visualization. T- test statistical analysis was also performed on ACR phantom scores. Results: The spatial resolution of C-View images is markedly lower (at least 50% worse) than that of FFDM. And while this is generally associated with the benefit of reduced relative noise magnitude, the noise in C-View images tends to have a more mottled (predominantly low-frequency) texture. In general, for high contrast objects, C-View provides superior visualization over FFDM; however this benefit diminishes for low contrast objects and is applicable only to objects that are sufficiently larger than the spatial resolution threshold. Based on both observer and automated ACR phantom analysis, between 50–70% of C-View images failed to meet ACR minimum accreditation requirements – primarily due to insufficient (unbroken) fiber visibility. Conclusion: Compared to FFDM, C-View offers better depiction of objects of certain size and contrast, but provides poorer overall resolution and noise properties. Based on these findings, the utilization of C-View images in the clinical setting requires careful consideration, especially if considering the discontinuation of FFDM imaging.
Distributed and Privacy-Preserving Data Dissemination at the Network Edge via Attribute-Based Searchable Encryption (2022)

Multi-Access Edge computing represents one of the most important enabling technologies for the Industrial Internet of Things. It allows advanced data processing and customized service provisioning, very close to the end-users. In the presence of many Multi-Access Edge computing applications, however, it is fundamental to ensure effective and privacy-preserving data dissemination at the network edge. From the security perspective, Attribute-based Encryption and Searchable Encryption techniques can be jointly used to achieve data confidentiality, flexible protection against unauthorized access, and privacy-preserving data dissemination. Available solutions, however, generally focus the attention on cloud-based approaches, use edge computing to implement some of the cryptographic tasks, and limit the investigation to single cryptographic operations. Indeed, no works investigate the adoption of these techniques in scenarios with multiple data producers and end-users, and fully operating at the network edge. To bridge this gap, this work proposes a novel methodology supporting fast and privacy-oriented data dissemination directly at the network edge. In the considered distributed network infrastructure, Multi-Access Edge computing applications express the interest to receive specific data by sending Trapdoors to Edge Servers. Data sources protect their contents through Attribute-based Encryption and deliver them to Edge Servers. In turn, Edge Servers implement Attribute-based Searchable Encryption functionalities to properly disseminate received contents towards Multi-Access Edge nodes hosting the applications that generated valid Trapdoors. The performance of the conceived approach has been evaluated through computer simulations. Obtained results highlight the benefits achieved against baseline (i.e., cloud-based) solutions.
Temperature and water controls on vegetation emergence, microbial dynamics, and soil carbon and nitrogen fluxes in a high Arctic tundra ecosystem (2012)

Summary Arctic tundra ecosystems contain 14% of the global soil carbon ( C ) store which is becoming vulnerable to decomposition. Arctic soil organic matter ( SOM ) contains large amounts of old, recalcitrant, high molecular weight ( MW ) C compounds which are protected from decomposition whilst soils remain frozen. Climatic change alters soil temperature and water regimes in the Arctic, however, the impact of these changes on C decomposition and storage is poorly understood. We investigated vegetation emergence, microbial dynamics and nutrient fluxes in response to snow melt on the high A rctic S valbard archipelago using field and laboratory studies. Using bacterial and archaeal genetic material (16 S rRNA ) and ammonia‐oxidising genes, microbial communities were quantified in transects across the active snow melt front. The effects of soil temperature and water content on SOM decomposition rates were measured using 14 C ‐labelled low and high MW compounds. Vegetation and below‐ground microbial communities, in the field, responded rapidly with peaks in nutrient availability and soil respiration observed within 72 h of snowmelt. Temperature strongly drives early growing season C dynamics in the A rctic. We suggest the nutrient peaks following snowmelt, coupled with higher levels of DNA in the subniveal zone are due to the decomposition of bacteria and archaea from previous years. We show, in the laboratory, when soils thaw, mineralisation of recalcitrant C (high MW ) compounds was sensitive to soil water but not to increasing temperatures. In contrast, low MW compounds exhibited sensitivity to both temperature and soil water. We suggest that if future soil water content increases under climate change, high MW compounds could become more susceptible to decomposition, releasing more C to the atmosphere.
Isı Değiştiricili Hava Sızdırmalı Güneş Toplayıcılarının Teorik ve Deneysel İncelemesi (2017)

zet: Hava szdrmal gne toplayclar
New challenges in the long-COVID syndrome (2023)

Journal Article New challenges in the long-COVID syndrome Get access H Sun, H Sun Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaDepartment of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, 212001, ChinaSchool of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212001, China Search for other works by this author on: Oxford Academic PubMed Google Scholar J Zhou, J Zhou Zhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang, Jiangsu 212001, China Search for other works by this author on: Oxford Academic PubMed Google Scholar L -J Tang, L -J Tang Zhenjiang Mental Health Center, The Fifth People's Hospital of Zhenjiang City, Zhenjiang, Jiangsu 212001, China Search for other works by this author on: Oxford Academic PubMed Google Scholar W -P Cao, W -P Cao School of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaThe Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, China Search for other works by this author on: Oxford Academic PubMed Google Scholar Y -M Li Y -M Li Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, ChinaDepartment of Dermatology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, 212001, ChinaSchool of Medicine, Jiangsu University, Zhenjiang, Jiangsu 212001, China Address correspondence to Y.-M. Li, Institute of Regenerative Medicine, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212001, China. email: yumeili@ujs.edu.cn Search for other works by this author on: Oxford Academic PubMed Google Scholar QJM: An International Journal of Medicine, Volume 116, Issue 7, July 2023, Page 608, https://doi.org/10.1093/qjmed/hcad041 Published: 14 March 2023 Article history Received: 10 March 2023 Published: 14 March 2023 Corrected and typeset: 21 March 2023
Functionalized chitosan derivatives as nonviral vectors: physicochemical properties of acylated N,N,N-trimethyl chitosan/oligonucleotide nanopolyplexes (2015)

Cationic polymers have recently attracted attention due to their proven potential for nonviral gene delivery. In this study, we report novel biocompatible nanocomplexes produced using chemically functionalized N,N,N-trimethyl chitosan (TMC) with different N-acyl chain lengths (C5-C18) associated with single-stranded oligonucleotides. The TMC derivatives were synthesized by covalent coupling reactions of quaternized chitosan with n-pentanoic (C5), n-decanoic (C10), and n-octadecanoic (C18) fatty acids, which were extensively characterized by Fourier transform-infrared spectroscopy (FT-IR) and proton nuclear magnetic resonance ((1)H NMR). These N-acylated TMC derivatives (TMCn) were used as cationic polymeric matrices for encapsulating anionic 18-base single-stranded thiophosphorylated oligonucleotides (ssONs), leading to the formation of polyplexes further characterized by zeta potential (ZP), dynamic light scattering (DLS), binding affinity, transfection efficiency and in vitro cytotoxicity assays. The results demonstrated that the length of the grafted hydrophobic N-acyl chain and the relative amino:phosphate groups ratio (N/P ratio) between the TMC derivatives and ssON played crucial roles in determining the physicochemical properties of the obtained nanocomplexes. While none of the tested derivatives showed appreciable cytotoxicity, the type of acyl chain had a remarkable influence on the cell transfection capacity of TMC-ssON nanocomplexes with the derivatives based on stearic acid showing the best performance based on the results of in vitro assays using a model cell line expressing luciferase (HeLa/Luc705).
Growth of Epitaxial β-FeSi<sub>2</sub> Thin Film on Si(001) by Metal-Organic Chemical Vapor Deposition (2004)

(100)-Oriented epitaxial β-FeSi 2 films 200 nm in thickness were grown on Si(001) substrates using a 20-nm-thick template layer prepared by reactive deposition epitaxy (RDE). The films maintained a strong (100) orientation and the full width at half maximum ( FWHM ) of the rocking curve corresponding to the β-FeSi 2 800 diffraction peak decreased from 0.96° to 0.92° with post-annealing at 1173 K in Ar atmosphere for 300 min, suggesting a slight increase in orientation perfection. The films maintained a flat surface after the post-annealing up to 300 min. No photoluminescence (PL) spectrum was observed from the as-deposited film. However, a PL of 0.80 6 eV was observed at 10 K for the first time from the epitaxial β-FeSi 2 film with a good surface flatness, when the film was post-annealed at 1173 K for 300 min.
Medication Use in the Management of Comorbidities Among Individuals With Autism Spectrum Disorder From a Large Nationwide Insurance Database (2021)

This study demonstrated considerable variability and transiency in the use of prescription medications by US clinicians to manage symptoms and comorbidities associated with ASD. These findings support the importance of early and ongoing surveillance of patients with ASD and co-occurring conditions and offer clinicians insight on the targeted therapies most commonly used to manage co-occurring conditions. Future research and policy efforts are critical to assess the extent to which pharmacological management of comorbidities affects quality of life and functioning in patients with ASD while continuing to optimize clinical guidelines, to ensure effective care for this growing population.
Optimizing CdTe solar cell performance; Impact of variations in minority carrier lifetime and carrier density profile (2011)

Summary form only given. Using numerical simulations, we study the combined effects of minority carrier lifetime and carrier density variation, that is observed in actual CdTe solar cells, on device performance. High open-circuit voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">oc</sub> ) requires high built in potential as well as low recombination rate in the space-charge region (SCR). Therefore, in a uniformly doped device, maximum open-circuit voltage will be obtained for high carrier density and high lifetime. The fill-factor (FF) is mainly dependent on the minority carrier lifetime. In a case of a highly defective absorber with high carrier density, the SCR is narrow in forward bias and some of the photogeneration occurs outside of the SCR. When the diffusion length is short, these carriers are likely to recombine before being collected, thus creating voltage dependent collection, and FF decrease. For a low carrier density, on the other hand, the electric field strength in the SCR is low enough, that for low lifetimes recombination is a competitive process to drift. This again reduces the FF for low lifetimes. Simulations predict that it is possible to increase the device efficiency for lower carrier density, 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">13</sup> -10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">14</sup> cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-3</sup> , if the back of the absorber is highly doped. This configuration increases the built in potential and the electric field close to the junction region. In addition, a device with such a doping profile is very tolerant towards the minority carrier lifetime of the highly doped layer. Our simulations show that efficiencies greater than 18% are possible using high doping at the back of the absorber. In contrast, when the absorber properties are uniform, efficiencies >;18% require unrealistic doping and lifetime values.