gebhart/patrepeval huggingface dataset:
Highly enantioselective ylide-mediated synthesis of terminal epoxides (2012)

The highly efficient asymmetric epoxidation of aldehydes by methylene transfer is now possible using new sulfonium salts.
Structure of ginseng major latex-like protein 151 and its proposed lysophosphatidic acid-binding mechanism (2015)

Lysophosphatidic acid (LPA) is a phospholipid growth factor with myriad effects on biological systems. LPA is usually present bound to animal plasma proteins such as albumin or gelsolin. When LPA complexes with plasma proteins, it binds to its cognate receptors with higher affinity than when it is free. Recently, gintonin from ginseng was found to bind to LPA and to activate mammalian LPA receptors. Gintonin contains two components: ginseng major latex-like protein 151 (GLP) and ginseng ribonuclease-like storage protein. Here, the crystal structure of GLP is reported, which belongs to the plant Bet v 1 superfamily, and a model is proposed for how GLP binds LPA. Amino-acid residues of GLP recognizing LPA were identified using site-directed mutagenesis and isothermal titration calorimetry. The resulting GLP mutants were used to study the activation of LPA receptor-dependent signalling pathways. In contrast to wild-type GLP, the H147A mutant did not bind LPA, elicit intracellular Ca(2+) transients in neuronal cells or activate Ca(2+)-dependent Cl(-) channels in Xenopus oocytes. Based on these results, a mechanism by which GLP recognizes LPA and its requirement to activate G protein-coupled LPA receptors to elicit diverse biological responses were proposed.
Automatic generation of application-specific architectures for heterogeneous multiprocessor system-on-chip (2001)

We present a design flow for the generation of application-specific multiprocessor architectures. In the flow, architectural parameters are first extracted from a high-level system specification. Parameters are used to instantiate architectural components, such as processors, memory modules and communication networks. The flow includes the automatic generation of communication coprocessor that adapts the processor to the communication network in an application-specific way. Experiments with two system examples show the effectiveness of the presented design flow.
Scalable Semi-Supervised Learning over Networks using Nonsmooth Convex Optimization (2016)

We propose a scalable method for semi-supervised (transductive) learning from massive network-structured datasets. Our approach to semi-supervised learning is based on representing the underlying hypothesis as a graph signal with small total variation. Requiring a small total variation of the graph signal representing the underlying hypothesis corresponds to the central smoothness assumption that forms the basis for semi-supervised learning, i.e., input points forming clusters have similar output values or labels. We formulate the learning problem as a nonsmooth convex optimization problem which we solve by appealing to Nesterovs optimal first-order method for nonsmooth optimization. We also provide a message passing formulation of the learning method which allows for a highly scalable implementation in big data frameworks.
Tables of Glycosidase Inhibitors with Nitrogen in the Sugar Ring and Their Inhibitory Activities: Introduction (1998)

This appendix contains sections titled: Introduction Legend Contents
ChemInform Abstract: Recent Advances in the Development of Dopamine D<sub>3</sub> Receptor Antagonists: A Medicinal Chemistry Perspective (2011)

Abstract Review: ca. 150 refs.
Fator de diferenciação de crescimento 15: um novo biomarcador em pacientes com disfunção diastólica? (2011)

Growth differentiation factor-15 levels are elevated in subjects with HFnEF and can differentiate normal diastolic function from asymptomatic LVDD. In addition, GDF-15 is associated with a reduced cardiac output response in the orthostatic hemodynamic test.
Terahertz quantum cascade laser based on GaSb/AlGaSb material system (2007)

Terahertz Quantum cascade laser using a resonant longitudinal-optical phonon depopulation scheme based on GaSb/AlGaSb material system on GaAs substrate has been proposed and studied. A smaller threshold electric field is expected for GaSb/AlGaSb QCL because GaSb has smaller longitudinal-optical phonon energy than that of GaAs. Although, there exists a large lattice mismatch between GaAs and GaSb, it was successfully demonstrated that the THz-QCL structures of GaSb/AlGaSb active layers on GaAs substrate were fabricated.
ChemInform Abstract: Cobalt‐Catalyzed Coupling of Alkyl Grignard Reagent with Benzamide and 2‐Phenylpyridine Derivatives Through Directed C—H Bond Activation under Air. (2011)

Abstract Various aromatic carboxamides and ortho‐phenylpyridine derivatives are ortho‐alkylated with Grignard reagents using air as a sole oxidant.
Janus Reveals Another Face: The Biologic Rationale for Targeting Janus Kinase 2 in Lymphoma (2012)

Article Tools UNDERSTANDING THE PATHWAY Article Tools OPTIONS & TOOLS Export Citation Track Citation Add To Favorites Rights & Permissions COMPANION ARTICLES No companion articles ARTICLE CITATION DOI: 10.1200/JCO.2012.44.0347 Journal of Clinical Oncology - published online before print September 10, 2012 PMID: 22965959 Janus Reveals Another Face: The Biologic Rationale for Targeting Janus Kinase 2 in Lymphoma Ann MullallyxAnn MullallySearch for articles by this author , Benjamin L. EbertxBenjamin L. EbertSearch for articles by this author Show More Brigham and Women's Hospital, Harvard Medical School, Boston, MA https://doi.org/10.1200/JCO.2012.44.0347 First Page Full Text PDF Figures and Tables © 2012 by American Society of Clinical Oncology
Newborn care practices and home-based postnatal newborn care programme – Mewat, Haryana, India, 2013 (2014)

Knowledge-practice gaps existed among mothers counselled by ASHAs. Poor utilization of reproductive and child health services decreased opportunities for ASHA-mother dialogue on safe practices. Recommendations included training ANMs, training TBAs as ASHAs, innovative communication strategies for ASHAs and improved referral system.
Dynamic Modeling and Control of Three-Degree-of-Freedom Electromagnetic Actuator for Image Stabilization (2018)

Recently, image quality deteriorations due to vibrations have become a problem in an autonomous system. A lens-unit-swing (LUS) system which consists of a lens and an imaging device is a kind of image stabilization technologies that generate an inverse motion against camera shakes. The LUS system can correct an image from camera shakes over wide rotation ranges around three axes. On the other hand, this system has some problems such as an increase in size and weight. In order to solve these problems, we proposed a novel three-degree-of-freedom electromagnetic actuator for image stabilization (3D-EAIS). In this paper, we propose a dynamic modeling method for the 3D-EAIS. A state equation of the 3D-EAIS is derived. The dynamic analysis results using the derived state equation and an electromagnetic field analysis using the 3-D finite-element method are compared, and the validity of the derived state equation is investigated. Moreover, the attitude stabilization system using a sliding mode control is constructed based on the derived state equation. The disturbance response of the stabilization control system is calculated, and the effectiveness of the control system is verified.
Le Zoo de Saint-Denis dans le quartier du Chaudron de sa naissance à sa fermeture définitive au public, 1976-2006. (2021)

L’histoire des animaux a La Reunion est un vaste champ encore peu explore. Retracer l’histoire du zoo de Saint-Denis dans le quartier du Chaudron durant ses annees d’ouverture au public (1976- 2006) c’est aborder ce champ par l’histoire d’un espace, lieu d’une rencontre forcee entre l’etre humain et l’animal sauvage, et d’une pratique, la mise en captivite puis l’exposition d’animaux sauvages vivants. Caracterise par un decalage avec les normes de son temps, cette structure municipale offre l’illustration d’un regard contraste sur l’animal captif. Ce regard evolue au fil du temps, entre fascination et repugnance le spectacle de nature sauvage controlee qu’offre l’animal de zoo ne laisse pas le visiteur indifferent.
Supplementary Figure 1 from An Integrated Genomic Screen Identifies LDHB as an Essential Gene for Triple-Negative Breast Cancer (2023)

&lt;p&gt;PDF file - 963K, Additional top targets from RNAi screen that are specifically required for triple negative breast cancer&lt;/p&gt;
Independent Regulation of Flowering by Phytochrome B and Gibberellins in Arabidopsis1 (1999)

Phytochromes and gibberellins (GAs) coordinately regulate multiple aspects of Arabidopsis development. Phytochrome B (PHYB) promotes seed germination by increasing GA biosynthesis, but inhibits hypocotyl elongation by decreasing the responsiveness to GAs. Later in the life cycle of the plant, PHYB and GAs have opposite effects on flowering. PHYB delays flowering, while GAs promote flowering, particularly under noninductive photoperiods. To learn how PHYB and GAs interact in the control of flowering, we have analyzed the effect of a phyB mutation on flowering time and on the expression of the floral meristem-identity gene LFY (LEAFY). We show that the early flowering caused by phyB correlated with an increase in LFY expression, which complements our previous finding that GAs are required for activation of LFY under noninductive photoperiods (M.A. Blázquez, R. Green, O. Nilsson, M.R. Sussman, D. Weigel [1998] Plant Cell 10: 791-800). Since phyB did not change the GA responsiveness of the LFY promoter and suppressed the lack of flowering of severe GA-deficient mutants under short days, we propose that PHYB modulates flowering time at least partially through a GA-independent pathway. Interestingly, the effects of PHYB on flowering do not seem to be mediated by transcriptional up-regulation of genes such as CO (CONSTANS) and FT (Flowering locus T), which are known to mediate the effects of the photoperiod-dependent floral-induction pathway.
SOC equilibrium control of energy storage system based on cascaded H-bridge (2021)

Aiming at the imbalance of phase and SOC of H-bridge cascade energy storage system, based on the analysis of the topological structure and mathematical model of cascade energy storage system, this paper proposes a SOC equalisation control strategy for cascade energy storage system based on negative sequence voltage injection, and deduces and analyses the working principle of SOC adaptive equalisation control strategy. On the premise of not affecting the current response of the system, the interphase and intra-phase SOC balance of the cascade energy storage system can be realised. Finally, a cascaded energy storage system model is built in the MATLAB Simulink simulation environment. The simulation results verify the correctness and effectiveness of the proposed SOC adaptive equalisation control strategy.
VLA observations of Cepheid variables (1988)

The 3-sigma, 5 GHz flux-density upper limits between 120 and 180 microJy have been obtained for the classical Cepheids FF Aql, Eta Aql, SU Cas, Delta Cep, and T Mon, and the Type II Cepheids CS Cas and SW Tau using the VLA. On the basis of assumptions outlined in the main text, upper limits for the ionized mass-loss rates of order 10 to the -9th to 10 to the -7th solar masses/yr are derived for these stars.
New Evidence of Head-to-Tail Complex Formation of SDS–DOH Mixtures Adsorbed at the Air–Water Interface as Revealed by Vibrational Sum Frequency Generation Spectroscopy and Isotope Labelling (2019)

Details about the molecular structures of surfactant mixtures adsorbed at the air-water interface have been controversial. Using sum frequency generation vibrational spectroscopy (SFG) and isotope labeling, we show here for the first time that mixtures of dodecanol (DOH) and sodium dodecyl sulfate (SDS) adsorb at the air-water interface with the formation of a head-to-tail complex. We observed this complex formation to occur first in the aqueous subphase, followed by complex adsorption onto the interface. This new piece of evidence for the head-to-tail complex conformation contradicts the conjectured tail-to-tail adsorption of the surfactant mixtures. The SFG data also show the dominating adsorption of the SDS-DOH complex over the single molecules of SDS and DOH at the air-water interface. The interfacial DOH-to-SDS molecular ratio of approximately 2.2:1 at a DOH-to-SDS bulk concentration ratio of 10 μM/2 mM was determined by isotope labeling of the surfactants. In addition to a smaller number of gauche defects, the DOH-SDS complex was found to adopt a higher level of orderliness than the adsorbed single surfactants. These findings provide important insights into the descriptions and interpretation of DOH-SDS adsorption at the air-water interface and its properties.
Performance of a wireless access protocol on correlated Rayleigh-fading channels with capture (1998)

The throughput performance of a wireless media access protocol taking into account the effect of correlated channel fading, capture, and propagation delay is analyzed. For efficient access on the uplink (mobile-to-base-station link), the protocol makes use of the uplink channel status information which is conveyed to the mobiles through a busy/idle flag broadcast on the downlink (base-station-to-mobile link). A first-order Markov model is used to describe the correlation in the packet success/failure process on a Rayleigh-fading channel. The analytical results obtained through the first-order Markov approximation of the channel are compared to those obtained from an independent and identically distributed (i.i.d.) channel model. The Markovian-fading channel model is shown to provide better performance results than the i.i.d. channel model. Simulations show that a first-order Markov approximation of the Rayleigh-fading process is quite accurate. An enhanced version of the access protocol to take advantage of the memory in the fading channel behavior is proposed and analyzed. The effect of retransmission of erroneous data packets and propagation delay on the throughput is also analyzed. It is shown that the access protocol with an error detect (ED) feature is efficient in slow fading (e.g., pedestrian user speeds), whereas a retransmission protocol is more efficient in fast fading (e.g., vehicular user speeds).
TRIAMCINOLONE ACETONIDE–ASSISTED PARS PLANA VITRECTOMY IMPROVES RESIDUAL POSTERIOR VITREOUS HYALOID REMOVAL (2007)

TA-assisted PPV clearly demonstrated the residual posterior hyaloid on ILM and allowed more efficient removal of the posterior hyaloid than standard PPV.
On the impact of additive disturbances on Auto-Steering Systems (2017)

Several control techniques are available for the automotive systems and their design is often based on the available measurements of different parameters and the integration of the hard input and performance constraints. The objective of the present study is to revisit the closed loop dynamics of an auto-steering system to offer an evaluation of the impact of the curvature of the road. From a theoretical point of view, robust positive invariance theory is presented in order to perform the analysis of the effects that a bounded parameter-varying additive disturbance has on a linear parameter-varying controller used to ensure stability of a model predictive control strategy.
MRI accurately identifies early murine mammary cancers and reliably differentiates between <i>in situ</i> and invasive cancer: correlation of MRI with histology (2015)

MRI methods that accurately identify various stages of mouse mammary cancer could provide new knowledge that may have a direct impact on the management of breast cancer in patients. This research investigates whether we can accurately follow the progression from in situ to invasive cancer by the evaluation of in vivo and ex vivo MRI, and in comparison with histology as the gold standard for the diagnosis and staging of cancer. Six C3(1)SV40Tag virgin female mice, aged 12-16 weeks, were studied. At this age, these mice develop in situ cancer that resembles human ductal carcinoma in situ (DCIS). Fast spin-echo images of inguinal mammary glands were acquired at 9.4 T. After in vivo MRI, mice were sacrificed; inguinal mammary glands were excised and fixed in formalin for ex vivo MRI. Three-dimensional, volume-rendered, in vivo and ex vivo MR images were then correlated with histology. High-resolution ex vivo scans facilitated the comparison of in vivo scans with histology. The sizes of mammary cancers classified as in situ on the basis of histology ranged from 150 to 400 µm in largest diameter, and the average signal intensity relative to muscle was 1.40 ± 0.18 on T2 -weighted images. Cancers classified as invasive on the basis of histology were >400 µm in largest diameter, and the average intensity relative to muscle on T2 -weighted images was 2.34 ± 0.26. Using a cut-off of 400 µm in largest diameter to distinguish between in situ and invasive cancers, a T2 -weighted signal intensity of at least 1.4 times that of muscle for in situ cancer, and at least 2.3 times that of muscle for invasive cancer, 96% of in situ and 100% of invasive cancers were correctly identified on in vivo MRI, using histology as the gold standard. Precise MRI-histology correlation demonstrates that MRI reliably detects early in situ cancer and differentiates in situ from invasive cancers in the SV40Tag mouse model of human breast cancer.
PBSword: a web server for searching similar protein-protein binding sites (2012)

PBSword is a web server designed for efficient and accurate comparisons and searches of geometrically similar protein-protein binding sites from a large-scale database. The basic idea of PBSword is that each protein binding site is first represented by a high-dimensional vector of 'visual words', which characterizes both the global and local shape features of the binding site. It then uses a scalable indexing technique to search for those binding sites whose visual words representations are similar to that of the query binding site. Our system is able to return ranked results of binding sites in short time from a database of 194 322 domain-domain binding sites. PBSword supports query by protein ID and by new structures uploaded by users. PBSword is a useful tool to investigate functional connections among proteins based on the local structures of binding site and has potential applications to protein-protein docking and drug discovery. The system is hosted at http://pbs.rnet.missouri.edu.
Supplementary Table S3 from Preclinical Development of a Bispecific Antibody that Safely and Effectively Targets CD19 and CD47 for the Treatment of B-Cell Lymphoma and Leukemia (2023)

&lt;p&gt;Supplementary Table S3 shows the ratio of AUC0-inf low/high dose for the PK single dose study.&lt;/p&gt;
The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy (2016)

Cardiac hypertrophic growth in response to pathological cues is associated with reexpression of fetal genes and decreased cardiac function and is often a precursor to heart failure. In contrast, physiologically induced hypertrophy is adaptive, resulting in improved cardiac function. The processes that selectively induce these hypertrophic states are poorly understood. Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K27me3, which are involved in stable cellular differentiation, specifically in cardiomyocytes from physiologically and pathologically hypertrophied rat hearts, and correlated these marks with their associated transcriptomes. This analysis revealed the pervasive loss of euchromatic H3K9me2 as a conserved feature of pathological hypertrophy that was associated with reexpression of fetal genes. In hypertrophy, H3K9me2 was reduced following a miR-217-mediated decrease in expression of the H3K9 dimethyltransferases EHMT1 and EHMT2 (EHMT1/2). miR-217-mediated, genetic, or pharmacological inactivation of EHMT1/2 was sufficient to promote pathological hypertrophy and fetal gene reexpression, while suppression of this pathway protected against pathological hypertrophy both in vitro and in mice. Thus, we have established a conserved mechanism involving a departure of the cardiomyocyte epigenome from its adult cellular identity to a reprogrammed state that is accompanied by reexpression of fetal genes and pathological hypertrophy. These results suggest that targeting miR-217 and EHMT1/2 to prevent H3K9 methylation loss is a viable therapeutic approach for the treatment of heart disease.
Neural tube closure requires the endocytic receptor Lrp2 and its functional interaction with intracellular scaffolds (2021)

Pathogenic mutations in the endocytic receptor LRP2 in humans are associated with severe neural tube closure defects (NTDs) such as anencephaly and spina bifida. Here, we have combined analysis of neural tube closure in mouse and in the African Clawed Frog <i>Xenopus laevis</i> to elucidate the etiology of Lrp2-related NTDs. <i>Lrp2</i> loss of function impaired neuroepithelial morphogenesis, culminating in NTDs that impeded anterior neural plate folding and neural tube closure in both model organisms. Loss of Lrp2 severely affected apical constriction as well as proper localization of the core planar cell polarity (PCP) protein Vangl2, demonstrating a highly conserved role of the receptor in these processes, which are essential for neural tube formation. In addition, we identified a novel functional interaction of Lrp2 with the intracellular adaptor proteins Shroom3 and Gipc1 in the developing forebrain. Our data suggest that, during neurulation, motifs within the intracellular domain of Lrp2 function as a hub that orchestrates endocytic membrane removal for efficient apical constriction, as well as PCP component trafficking in a temporospatial manner.
A model for simulating speckle-pattern evolution based on close to reality procedures used in spectral-domain OCT (2014)

A robust model for simulating speckle pattern evolution in optical coherence tomography (OCT) depending on the OCT system parameters and tissue deformation is reported. The model is based on application of close to reality procedures used in spectral-domain OCT scanners. It naturally generates images reproducing properties of real images in spectral-domain OCT, including the pixelized structure and finite depth of unambiguous imaging, influence of the optical spectrum shape, dependence on the optical wave frequency and coherence length, influence of the tissue straining, etc. Good agreement with generally accepted speckle features and properties of real OCT images is demonstrated.
Synthesis of Superconducting InxSn1−xTe (0.04 &lt; x &lt; 0.1) Large Single Crystal by Liquid Transport Method (2021)

In this work, a new crystal growth technique called the liquid transport method was introduced to synthesize single crystals of a topological superconductor candidate, InxSn1−xTe (IST). Crystals with the size of several millimeters were successfully synthesized, and were characterized by X-ray diffraction, scanning electron microscopy with energy-dispersive spectroscopy as well as electronic transport measurements. Lattice parameters decreased monotonously with the increase of indium content while hole density varied in reverse. Superconductivity with the critical temperature (Tc) around 1.6 K were observed, and the hole densities were estimated to be in the order of 1020 cm−3. The upper critical fields (Bc2) were estimated to be 0.68 T and 0.71 T for In0.04Sn0.96Te and In0.06Sn0.94Te, respectively. The results indicated that the quality of our crystals is comparable to that grown by the chemical vapor transport method, but with a relatively larger size. Our work provides a new method to grow large single crystals of IST and could help to solve the remaining open questions in a system that needs large crystals, such as a superconducting pairing mechanism, unconventional superconductivity, and so on.