gebhart/patrepeval huggingface dataset:
THE H3/H4 HISTONE GENE CLUSTER OF LAND SNAILS (GASTROPODA: STYLOMMATOPHORA): TS/TV RATIO, GC3 DRIVE AND SIGNALS IN STYLOMMATOPHORAN PHYLOGENY (2005)

Histone gene primers were developed for land snails (Stylommatophora). The partial H3/H4 histone gene cluster was cloned and sequenced for 18 species. Transcription of the H3 and H4 genes was divergent (each gene is transcribed in the opposite direction) as has been found for other protostome and diploblast animals, with the exception of Mytilus. In the bivalve Mytilus transcription of both genes occurs in the same direction, i.e. land snails and bivalves seem to differ in their histone gene organization. The non-transcribed H3/H4 spacer varied in length between 279 and 691 basepairs. Nucleotide polymorphisms in this non-transcribed spacer might be of significance to study phylogenetics and systematics of closely related species and genera. As expected, the coding regions exhibited no amino acid substitution among land snail species. However, one amino acid substitution was found in comparison between land snails and Drosophila. The transition/transversion (TS/TV) ratio of H3 and H4 was predominately shaped by the third codon position and ranged in most cases from 1.0 to 2.0, indicating low nucleotide saturation. GC content was calculated for the third codon position (GC3 index at the ‘wobble’ base position). The histone GC3 values were far lower in land snails than values currently available for other genomes (i.e. mammals). This indicates that H3/H4 histone wobble bases of land snails evolve without strong GC drive. Phylogenetic trees were reconstructed from the coding regions. We used Succinea putris (Elasmognatha) as outgroup. Trichia villosa (Helicoidea) showed six apomorphic nucleotide signals. Moreover, the nucleotide signals give evidence that the Cochlicopidae, Vertiginidae and Valloniidae are paraphyletic family categories. The paraphyletic status of cochlicopid, vertiginid and valloniid gastropods is also supported by our unpublished ribosomal DNA trees.
Fast Motion Rendering for Single-Chip Stereo DLP Projectors (2012)

Single-chip color DLP projectors show the red, green and blue components one after another. When the gaze moves relative to the displayed pixels, color fringes are perceived. In order to reduce these artefacts, many devices show the same input image twice at the double rate, i.e. a 60Hz source image is displayed with 120Hz. Consumer stereo projectors usually work with time interlaced stereo, allowing to address each of these two images individually. We use this so called 3D mode for mono image display of fast moving objects. Additionally, we generate a separate image for each individual color, taking the display time offset of each color component into account. With these 360 images per second we can strongly reduce ghosting, color fringes and jitter artefacts on fast moving objects tracked by the eye, resulting in sharp objects with smooth motion. Real-time image generation at such a high frame rate can only be achieved for simple scenes or may only be possible by severely reducing quality. We show how to modify a motion blur post processing shader to render only 60frames
Retinoic acid plus arsenic trioxide, the ultimate panacea for acute promyelocytic leukemia? (2013)

Rarely in the field of cancer treatment did we experience as many surprises as with acute promyelocytic leukemia (APL). Yet, the latest clinical trial reported by Lo-Coco et al in the New England Journal of Medicine is a practice-changing study, as it reports a very favorable outcome of virtually all enrolled low-intermediate risk patients with APL without any DNA-damaging chemotherapy. Although predicted from previous small pilot studies, these elegant and stringently controlled results open a new era in leukemia therapy.
The emergence of a networking primitive in wireless sensor networks (2008)

The wireless sensor network community approached networking abstractions as an open question, allowing answers to emerge with time and experience. The Trickle algorithm has become a basic mechanism used in numerous protocols and systems. Trickle brings nodes to eventual consistency quickly and efficiently while remaining remarkably robust to variations in network density, topology, and dynamics. Instead of flooding a network with packets, Trickle uses a "polite gossip" policy to control send rates so each node hears just enough packets to stay consistent. This simple mechanism enables Trickle to scale to 1000-fold changes in network density, reach consistency in seconds, and require only a few bytes of state yet impose a maintenance cost of a few sends an hour. Originally designed for disseminating new code, experience has shown Trickle to have much broader applicability, including route maintenance and neighbor discovery. This paper provides an overview of the research challenges wireless sensor networks face, describes the Trickle algorithm, and outlines several ways it is used today.
Low-loss non-volatile phase-change RF switching technology for system reconfigurability and reliability (2014)

A novel phase-change microelectronics technology is described to enable wideband reconfigurable RF systems and components for EW, RADAR and communications applications. This technology can lower the development time and cost of DoD systems for new missions by enabling factory or mission re-programmability. It can also support component redundancy in system architectures with little impact to system performance.
Docking and Migration of Carbon Monoxide in Nitrogenase: The Case for Gated Pockets from Infrared Spectroscopy and Molecular Dynamics (2015)

Evidence of a CO docking site near the FeMo cofactor in nitrogenase has been obtained by Fourier transform infrared spectroscopy-monitored low-temperature photolysis. We investigated the possible migration paths for CO from this docking site using molecular dynamics calculations. The simulations support the notion of a gas channel with multiple internal pockets from the active site to the protein exterior. Travel between pockets is gated by the motion of protein residues. Implications for the mechanism of nitrogenase reactions with CO and N2 are discussed.
ChemInform Abstract: Synthesis, Structural Characterization, and Reactivity of the Bis(η 5‐dicarbollide)silicon Sandwich Compound commo‐3,3′‐Si(3,1,2‐SiC2B9H11) 2. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
OPPORTUNITIES IN GREEN SUPPLY CHAIN MANAGEMENT (2009)

The supply chain consists of those activities associated with manufacturing from raw material acquisition to final product delivery. Because of the recently changed environmental requirements that affect manufacturing operations and transportation systems, growing attention is given to the development of environment management strategies for supply chains. A green supply chain aims at confining the wastes within the industrial system so as to conserve energy and prevent the dissipation of harmful materials into the environment. In this paper, we compare and contrast the traditional and green supply chains. Moreover, we discuss several important opportunities in green supply chain management in depth, including those in manufacturing, bio-waste, construction, and packaging.
Targeting hypertriglyceridemia to mitigate cardiovascular risk: A review (2020)

A causal relationship between elevated triglycerides and cardiovascular disease is controversial, as trials of triglyceride-lowering treatments have not shown significant impact on cardiovascular outcomes. However, hypertriglyceridemia is associated with atherogenesis and risk for acute cardiovascular events that persist despite optimal statin treatment. Although most trials of triglyceride-lowering treatments have been negative, in trials of niacin and fibrates, subgroup analyses in patients with higher baseline triglycerides and lower HDL-C levels suggest reduced incidence of cardiovascular endpoints. The REDUCE-IT trial demonstrated that addition of purified prescription eicosapentaenoic acid (icosapent ethyl) 4 ​g/day in high-risk patients with triglyceride levels 135-499 ​mg/dL and optimized statin treatment significantly reduced cardiovascular events versus placebo (hazard ratio 0.75; 95% confidence interval 0.68-0.83; <i>P</i> ​< ​0.001). Benefit was seen regardless of baseline and on-treatment triglyceride levels, suggesting that other effects of eicosapentaenoic acid besides triglyceride reduction may have played a role.
Comprehensive, powerful, efficient, intuitive: a new software framework for clinical imaging applications (2006)

One of the greatest challenges for a software engineer is to create a complex application that is comprehensive enough to be useful to a diverse set of users, yet focused enough for individual tasks to be carried out efficiently with minimal training. This "powerful yet simple" paradox is particularly prevalent in advanced medical imaging applications. Recent research in the Biomedical Imaging Resource (BIR) at Mayo Clinic has been directed toward development of an imaging application framework that provides powerful image visualization/analysis tools in an intuitive, easy-to-use interface. It is based on two concepts very familiar to physicians - Cases and Workflows. Each case is associated with a unique patient and a specific set of routine clinical tasks, or a <i>workflow</i>. Each workflow is comprised of an ordered set of general-purpose modules which can be re-used for each unique workflow. Clinicians help describe and design the workflows, and then are provided with an intuitive interface to both patient data and analysis tools. Since most of the individual steps are common to many different workflows, the use of general-purpose modules reduces development time and results in applications that are consistent, stable, and robust. While the development of individual modules may reflect years of research by imaging scientists, new customized workflows based on the new modules can be developed extremely fast. If a powerful, comprehensive application is difficult to learn and complicated to use, it will be unacceptable to most clinicians. Clinical image analysis tools must be intuitive and effective or they simply will not be used.
Evaluation of a hormone receptor‐positive ovarian carcinoma subtype with a favourable prognosis by determination of progesterone receptor and oestrogen receptor 1 mRNA expression in formalin‐fixed paraffin‐embedded tissue (2011)

Expression of PR and ESR1 defines a subgroup of ovarian carcinomas with a favourable prognosis. PR and ESR1 mRNA expression analysis is a sensitive, quantitative and easy-to-perform high-throughput analytical tool for the identification of this subgroup and could be predictive in clinical trials focused on patients with potential benefit from hormonal treatment.
Perching and takeoff of a robotic insect on overhangs using switchable electrostatic adhesion (2016)

For aerial robots, maintaining a high vantage point for an extended time is crucial in many applications. However, available on-board power and mechanical fatigue constrain their flight time, especially for smaller, battery-powered aircraft. Perching on elevated structures is a biologically inspired approach to overcome these limitations. Previous perching robots have required specific material properties for the landing sites, such as surface asperities for spines, or ferromagnetism. We describe a switchable electroadhesive that enables controlled perching and detachment on nearly any material while requiring approximately three orders of magnitude less power than required to sustain flight. These electroadhesives are designed, characterized, and used to demonstrate a flying robotic insect able to robustly perch on a wide range of materials, including glass, wood, and a natural leaf.
Combined Inhibition of TGF-β Signaling and the PD-L1 Immune Checkpoint Is Differentially Effective in Tumor Models (2019)

Antibodies blocking the programmed death-ligand 1 (PD-L1) have shown impressive and durable responses in clinical studies. However, this type of immunotherapy is only effective in a subset of patients and not sufficient for rejection of all tumor types. In this study, we explored in two mouse tumor models whether the antitumor effect could be enhanced by the combined blockade of PD-L1 and transforming growth factor-β (TGF-β), a potent immunosuppressive cytokine. The effect of anti-PD-L1 mouse monoclonal (mAb) and a TGF-β type I receptor small molecule kinase inhibitor (LY364947) was evaluated in the highly immunogenic mouse MC38 colon adenocarcinoma and the poorly immunogenic mouse KPC1 pancreatic tumor model. In the MC38 tumor model, LY364947 monotherapy did not show any antitumor effect, whereas treatment with anti-PD-L1 mAb significantly delayed tumor outgrowth. However, combination therapy showed the strongest therapeutic efficacy, resulting in improved long-term survival compared with anti-PD-L1 mAb monotherapy. This improved survival was associated with an increased influx of CD8⁺ T cells in the tumor microenvironment. In the KPC1 tumor model, LY364947 did not enhance the antitumor effect of anti-PD-L1 mAb. Despite this, delayed KPC1 tumor outgrowth was observed in the LY364947-treated group and this treatment led to a significant reduction of CD4⁺ T cells in the tumor microenvironment. Together, our data indicate that an additive anti-tumor response of dual targeting PD-L1 and TGF-β is dependent on the tumor model used, highlighting the importance of selecting appropriate cancer types, using in-depth analysis of the tumor microenvironment, which can benefit from combinatorial immunotherapy regimens.
Holographic optical assembly and photopolymerized joining of planar microspheres (2016)

The aim of this research is to demonstrate a holographically driven photopolymerization process for joining colloidal particles to create planar microstructures fixed to a substrate, which can be monitored with real-time measurement. Holographic optical tweezers (HOT) have been used to arrange arrays of microparticles prior to this work; here we introduce a new photopolymerization process for rapidly joining simultaneously handled microspheres in a plane. Additionally, we demonstrate a new process control technique for efficiently identifying when particles have been successfully joined by measuring a sufficient reduction in the particles' Brownian motion. This technique and our demonstrated joining approach enable HOT technology to take critical steps toward automated additive fabrication of microstructures.
Application of High-Resolution NMR and GC–MS to Study Hydrocarbon Oils Derived from Noncatalytic Thermal Transformation of e-Waste Plastics (2018)

The increases in the volumes of electronic waste have become an aggravating environmental, economic, and social health issue in recent times. This study investigates the conversion of e-waste plastics into hydrocarbon oils via noncatalytic thermal transformation followed by an in-depth characterization of these oils using diverse analytical techniques such as gas chromatography-mass spectrometry (GC-MS), Fourier transform infrared (FTIR) spectroscopy, and nuclear magnetic resonance (NMR) spectroscopy. In particular, NMR spectroscopy is a key analytical tool utilized in this study to gain a comprehensive insight into the chemical nature of the resultant oils along with a semiquantitative investigation of the changes in their composition over a temperature range of 800-1200 °C. The one-dimensional (1D) <sup>1</sup>H and two-dimensional (2D) heteronuclear single-quantum correlation spectra were acquired for the oils, wherein the 2D NMR spectrum provided improved resolution of peaks to address the overlaps encountered in the 1D spectrum. The experimental results obtained from GC-MS, FTIR spectroscopy, and NMR spectroscopy were found to align well with each other. The oils produced in this study have a high calorific value of 38.27 MJ/kg and thus may find use in several applications. A detailed mechanism for the thermal degradation of styrene acrylonitrile plastics and the formation of major products is elucidated in this study.
High cholesterol‐induced neuroinflammation and amyloid precursor protein processing correlate with loss of working memory in mice (2008)

Recent findings suggest that hypercholesterolemia may contribute to the onset of Alzheimer's disease-like dementia but the underlying mechanisms remain unknown. In this study, we evaluated the cognitive performance in rodent models of hypercholesterolemia in relation to neuroinflammatory changes and amyloid precursor protein (APP) processing, the two key parameters of Alzheimer's disease pathogenesis. Groups of normal C57BL/6 and low density lipoprotein receptor (LDLR)-deficient mice were fed a high fat/cholesterol diet for an 8-week period and tested for memory in a radial arm maze. It was found that the C57BL/6 mice receiving a high fat diet were deficient in handling an increasing working memory load compared with counterparts receiving a control diet while the hypercholesterolemic LDLR-/- mice showed impaired working memory regardless of diet. Immunohistochemical analysis revealed the presence of activated microglia and astrocytes in the hippocampi from high fat-fed C57BL/6 mice and LDLR-/- mice. Consistent with a neuroinflammatory response, the hyperlipidemic mice showed increased expression of cytokines/mediators including tumor necrosis factor-alpha, interleukin-1beta and -6, nitric oxide synthase 2, and cycloxygenase 2. There was also an induced expression of the key APP processing enzyme i.e. beta-site APP cleaving enzyme 1 in both high fat/cholesterol-fed C57BL/6 and LDLR-/- mice accompanied by an increased generation of C-terminal fragments of APP. Although ELISA for beta-amyloid failed to record significant changes in the non-transgenic mice, a threefold increase in beta-amyloid 40 accumulation was apparent in a strain of transgenic mice expressing wild-type human APP on high fat/cholesterol diet. The findings link hypercholesterolemia with cognitive dysfunction potentially mediated by increased neuroinflammation and APP processing in a non-transgenic mouse model.
2E14 Extending maintenance intervals of track switches utilising multi-channel redundancy of actuation and sensing(Infrastructure) (2015)

A concept for a novel track switch arrangement has been developed at Loughborough University, which, through a novel locking arrangement, allows parallel, multi-channel actuation and locking functions for the first time. This switch has been developed as part of the REPOINT project, and is referred to as the REPOINT switch. Existing track switches generally use a single-channel actuator and lock, and undergo an intensive maintenance and inspection regime to ensure an acceptable level of reliability/availability. This paper demonstrates, through mathematical modelling with very conservative assumptions, that an increase in switch availability is possible alongside a corresponding decrease in ongoing maintenance intensity using the REPOINT multi-channel approach. The paper firstly introduces the theory behind the design of the REPOINT switch, using a switch with 2-out-of-3 redundant actuation and sensing channels as an example. An existing switch is analysed using real-world data as a benchmark. Availability is determined by the target time in which Maintenance Teams must have replaced any failed components, expressed herein as τ. Availability measures are obtained as functions of τ which show the range of possible switch availability against maintenance response times, for the given set of assumptions. The results show that for a REPOINT installation, gains in system availability are possible even when response times are set many times longer than current standards, indicating a significant reduction in ongoing maintenance cost.
Cell‐Free Desensitization of Opioid Inhibition of Adenylate Cyclase in Neuroblastoma × Glioma NG108–15 Hybrid Cell Membranes (1986)

When membranes from neuroblastoma X glioma NG108-15 hybrid cells were incubated in a cell-free system with opioid agonists, a time-, temperature-, and dose-dependent desensitization to opioid inhibition of adenylate cyclase activity was observed. The composition of the system during the incubation was manipulated to elucidate the biochemical mechanisms of desensitization. Receptor coupling appeared to be a prerequisite for desensitization, because both magnesium and sodium, which are necessary for coupling, were required for desensitization. Removal of ATP and addition of cyclic AMP or cyclic GMP had no effect on desensitization.
High Light Outcoupling Efficiency from Periodically Corrugated OLEDs (2021)

Organic light-emitting diodes (OLEDs) suffer from poor light outcoupling efficiency (η<sub>out</sub> < 20%) due to large internal waveguiding in the high-index layers/substrate, and plasmonic losses at the metal cathode interface. A promising approach to enhance light outcoupling is to utilize internal periodic corrugations that can diffract waveguided and plasmonic modes back to the air cone. Although corrugations can strongly diffract trapped modes, the optimal geometry of corrugations and limits to η<sub>out</sub> are not well-established. We develop a general rigorous scattering matrix theory for light emission from corrugated OLEDs, by solving Maxwell's equations in Fourier space, incorporating the environment-induced modification of the optical emission rate (Purcell effect). We computationally obtain the spectrally emissive power inside and outside the OLED. We find conformally corrugated OLEDs, where all OLED interfaces are conformal with a photonic crystal substrate, having triangular lattice symmetry, exhibit high light outcoupling η<sub>out</sub> ∼60-65%, and an enhancement factor exceeding 3 for optimal pitch values between 1 and 2.5 μm. Waveguided and surface plasmon modes are strongly diffracted to the air cone through first-order diffraction. η<sub>out</sub> is insensitive to corrugation heights larger than 100 nm. There is a gradual roll-off in η<sub>out</sub> for a larger pitch and sharper decreases for small pitch values. Plasmonic losses remain below 10% for all corrugation pitch values. Our predicted OLED designs provide a pathway for achieving very high light outcoupling over the full optical spectrum that can advance organic optoelectronic science and solid-state lighting.
Organoselenium‐substituted poly(<i>p</i>‐phenylenevinylene) (2005)

Abstract A new type of conjugated polymer, organoselenium substituted poly( p ‐phenyleneviny‐ lene) (PPV), was synthesized from the corresponding alkylselenenyl p ‐xylylene dibromide via a Gilch route using potassium tert ‐butoxide in THF. The p ‐xylylene dibromide precursors were synthesized by reacting lithiated bis(methoxymethyl)benzenes with elemental selenium, followed by alkylation of the generated selenolates. As a final demasking step, the bromomethyl functions were liberated by ether cleavage using boron tribromide. Bis‐alkylselenenyl PPV was obtained with an average molecular weight M w of approximately 300,000 g/mol and with polydispersity M w / M n = 2. Due to low solubility, monoalkylselenenyl PPV was obtained with a considerably lower average molecular weight in the proximity of 16,000 g/mol and with a polydispersity slightly larger than 3. Absorption and fluorescence spectroscopy revealed that the bis‐alkylselenenyl PPV is extensively conjugated. © 2005 Wiley Periodicals, Inc. Heteroatom Chem 16:656–662, 2005; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20167
Correction to: Parma consensus statement on metabolic disruptors (2017)

After publication of the article [1], it has been brought to our attention that the thirteenth author of this article has had their name spelt incorrectly. In the original article the spelling "Laura Rizzir" was used. In fact the correct spelling should be "Laura Rizzi".