gebhart/patrepeval huggingface dataset:
Percent Absent End-Diastolic Velocity and Risk of Donor Twin Demise in Twin-Twin Transfusion Syndrome [19A] (2019)

INTRODUCTION: We examined the association of percent absent end-diastolic velocity (%AEDV) in the umbilical artery with intrauterine fetal demise (IUFD) of the donor twin after laser surgery in patients with twin-twin transfusion syndrome (TTTS) Quintero stages III/IV. %AEDV was calculated as 100x the proportion of total cardiac cycle spent in AEDV. METHODS: Retrospective study of TTTS stage III/IV patients between 2006 and 2016. Donors were classified as having persistent AEDV (yes/no). In Part 1, we used multiple logistic regression analysis to test whether AEDV was associated with donor IUFD. We stratified these analyses by estimated fetal weight (EFW) discordance of ≥20% or &lt;20%. In Part 2, we used similar models to test only those with AEDV to determine whether %AEDV was associated with IUFD. This was an IRB approved study. RESULTS: Of 344 stage III/IV TTTS cases, 153 (44.5%) donors had preoperative AEDV. In Part 1, we did not confirm an independent association between AEDV and donor IUFD. In Part 2, patients with AEDV who were discordant (N=129), had the following characteristics associated with donor IUFD: %AEDV (OR 1.04, 95% CI 1.01-1.08), %EFW discordance (OR 1.07, 95% CI 1.02-1.13), and presence of arterioarterial anastomoses (OR 5.15, 95% CI 2.06-12.89). In the non-discordant group (N=24), no association was found between %AEDV and donor IUFD. CONCLUSION: The presence of preoperative persistent AEDV was not an independent risk factor for donor IUFD in stage III/IV TTTS patients undergoing laser surgery. However, among donors with preoperative AEDV and EFW discordance ≥20%, %AEDV was positively associated with donor IUFD.
Randomized Load Balancing under Loosely Correlated State Information in Fog Computing (2020)

Fog computing infrastructures must support increasingly complex applications where a large number of sensors send data to intermediate fog nodes for processing. As the load in such applications (as in the case of a smart cities scenario) is subject to significant fluctuations both over time and space, load balancing is a fundamental task. In this paper we study a fully distributed algorithm for load balancing based on random probing of the neighbors' status. A qualifying point of our study is considering the impact of delay during the probe phase and analyzing the impact of stale load information. We propose a theoretical model for the loss of correlation between actual load on a node and stale information arriving to the neighbors. Furthermore, we analyze through simulation the performance of the proposed algorithm considering a wide set of parameters and comparing it with an approach from the literature based on random walks. Our analysis points out under which conditions the proposed algorithm can outperform the alternatives.
Asymmetric Atom Transfer Radical Polymerization: Enantiomer-Selective Cyclopolymerization of <i>rac</i>-2,4-Pentanediyl Dimethacrylate Using Chiral ATRP Initiator (2003)

The enantiomer-selective radical cyclopolymerization of the racemic mixture of (2R,4R-2,4-pentanediyl dimethacryrate (RR-1) and (2S,4S)-2,4-pentanediyl dimethacrylate (SS-1) was achieved using chiral atom transfer radical polymerization (ATRP) initiating systems. RR-1 and SS-1 were predominantly polymerized using methyl 2-bromoisobutyrate /CuBr/(S,S)-2,6-bis(4-isopropyl-2-oxazolin-2-yl)pyridine and methyl 2-bromoisobutyrate/RuCl2(PPh3)3/(S)- 1,1'-bi-2-naphthol, respectively. The enantiomer selectivity ratio was 1.3 ~ 3.2 for the Cu-catalyzed ATRP initiating system and ca. 1.0 ~ 3.4 for the Ru-catalyzed ATRP initiating system.
Interactive Vector Field Feature Identification (2010)

We introduce a flexible technique for interactive exploration of vector field data through classification derived from user-specified feature templates. Our method is founded on the observation that, while similar features within the vector field may be spatially disparate, they share similar neighborhood characteristics. Users generate feature-based visualizations by interactively highlighting well-accepted and domain specific representative feature points. Feature exploration begins with the computation of attributes that describe the neighborhood of each sample within the input vector field. Compilation of these attributes forms a representation of the vector field samples in the attribute space. We project the attribute points onto the canonical 2D plane to enable interactive exploration of the vector field using a painting interface. The projection encodes the similarities between vector field points within the distances computed between their associated attribute points. The proposed method is performed at interactive rates for enhanced user experience and is completely flexible as showcased by the simultaneous identification of diverse feature types.
Peroxisome proliferator‐activated receptor γ agonist troglitazone induces colon tumors in normal C57BL/6J mice and enhances colonic carcinogenesis in <i>Apc</i><sup>1638 N/+</sup><i>Mlh1</i><sup>+/−</sup> double mutant mice (2005)

The role of the nuclear peroxisome proliferator-activated receptor-gamma (PPAR-gamma) in colon tumorigenesis remains controversial. Notwithstanding evidence that PPAR-gamma ligands impede murine colorectal carcinogenesis, PPAR-gamma agonists have been shown to enhance in vivo tumor formation in mouse models of human colon cancer. Our study was designed to determine whether troglitazone (TGZ) induces colonic tumor formation in normal C57BL/6J mice and enhances colorectal carcinogenesis in double mutant Apc1638N/+ Mlh1+/- mice fed a standard AIN-76A diet. We report herein that not only does TGZ enhance carcinogenesis in the large intestine of mutant mice predisposed to intestinal carcinogenesis but TGZ also induces colonic tumors in normal mice without gene targeting or carcinogen administration. This observation indicates that preexisting mutational events are not necessary for induction of colonic tumors by activated PPAR-gamma in vivo.
Superoxide is promoted by sucrose and affects amplitude of circadian rhythms in the evening (2021)

Plants must coordinate photosynthetic metabolism with the daily environment and adapt rhythmic physiology and development to match carbon availability. Circadian clocks drive biological rhythms which adjust to environmental cues. Products of photosynthetic metabolism, including sugars and reactive oxygen species (ROS), are closely associated with the plant circadian clock, and sugars have been shown to provide metabolic feedback to the circadian oscillator. Here, we report a comprehensive sugar-regulated transcriptome of <i>Arabidopsis</i> and identify genes associated with redox and ROS processes as a prominent feature of the transcriptional response. We show that sucrose increases levels of superoxide (O<sub>2</sub><sup>-</sup>), which is required for transcriptional and growth responses to sugar. We identify circadian rhythms of O<sub>2</sub><sup>-</sup>-regulated transcripts which are phased around dusk and find that O<sub>2</sub><sup>-</sup> is required for sucrose to promote expression of TIMING OF CAB1 <i>(TOC1)</i> in the evening. Our data reveal a role for O<sub>2</sub><sup>-</sup> as a metabolic signal affecting transcriptional control of the circadian oscillator in <i>Arabidopsis</i>.
Collaborative Nanoscience Laboratory with Integrated Learning Modules (2003)

Creation and maintenance of virtual laboratories needs an interdisciplinary project team with didactic and technical staff and also experts of the field. NANO-WORLD, a collaborative nanoscience laboratory, developed as part of the Swiss Virtual Campus, is built on top of an e-learning portal. Interactive real-time simulations of nanoscience experiments inspire students to access e-learning modules. Remote experiments with mobile notification services increase the learning motivation of students. They can directly explore phenomena in nanoscience and take over the role of scientists.
Predictive factors for complications in elderly patients who underwent head and neck oncologic surgery (2007)

Abstract Background. Postoperative complications are relevant outcomes in patients with head and neck tumor who have undergone surgery. Few trials have assessed predictive factors in older patients. We assessed the predictive effect of preoperative clinical factors on postoperative complications. Methods. We conducted a cohort study with 242 patients older than 70 years with head and neck cancer who underwent surgery. Logistic regression identified predictive factors for postoperative complications. Significant variables were used to build a predictive index. Results. Comorbidities were present in 87.6% of patients, and 56.6% had some type of complication (44.6% local and 28.5% systemic). Male sex, bilateral neck dissection, presence of 2 or more comorbidities, reconstruction, and clinical stage IV were associated with postoperative complications. The predictive index showed a receiver operating characteristics curve (ROC) area of 0.69. Conclusion. It is possible to predict postoperative complications in older patients with head and neck tumors who underwent oncologic surgery using clinical preoperative variables. © 2007 Wiley Periodicals, Inc. Head Neck, 2008
An Embedded Memory-Centric Reconfigurable Hardware Accelerator for Security Applications (2015)

Security has emerged as a critical need in today's computer applications. Unfortunately, most security algorithms are computationally expensive and often do not map efficiently to general purpose processors. Fixed-function accelerators offer significant improvement in energy-efficiency, but they do not allow more than one application to reuse hardware resources. Mapping applications to generic reconfigurable fabrics can achieve the desired flexibility, but at the cost of area and energy efficiency. This paper presents a novel reconfigurable framework, referred to as hardware accelerator for security kernel (HASK), for accelerating a wide array of security applications. This framework incorporates a coarse-grained datapath, supports for lookup functions, and flexible interconnect optimizations, which enable on-demand pipelining and parallel computations in multiple ultralight-weight processing elements. These features are highly effective for energy-efficient operation in a diverse set of security applications. Through simulations, we have compared the performance of HASK to software and field programmable gate array (FPGA) platforms. Simulation results for a set of six common security applications show comparable latency between HASK and FPGA with 2.5X improvement in energy-delay product and 4X improvement in iso-area throughput. HASK also shows 5X improvement in iso-area throughput and 45X improvement in energy-delay product compared to optimized software implementations.
A partial map of the barley genome incorporating restriction fragment length polymorphism, polymerase chain reaction, isozyme, and morphological marker loci (1990)

Nine low copy number genomic DNA clones, a ribosomal sequence, and seven cDNA clones were found to identify polymorphisms in cultivated barley (Hordeum vulgare L.). An F2 population consisting of 100 plants was produced from a cross between a high-yielding two-rowed feed barley cultivar and a genetic marker stock homozygous for nine recessive and one dominant morphological marker genes. Through the use of these 10 well-distributed marker genes, five previously mapped isozyme loci, and two storage-protein loci, the approximate recombinational location for each of 17 restriction fragment length polymorphism loci was estimated. One clone, pMSU21, identified variation that appeared to be the result of a small insertion-deletion event that differentiated two-rowed and six-rowed genotypes. This difference was characterized, and one allele was sequenced. Oligonucleotide primers that flanked the insertion-deletion event were synthesized, and DNA samples from the F2 population were subjected to polymerase chain reaction sequence amplification. The variation identified by this technique was determined to be allelic to the variation identified using pMSU21 in Southern blot analysis. Maps of previously undescribed informative clones are included.
Revascularização do miocárdio com cirurgia minimamente invasiva (MIDCAB): resultados em 46 pacientes (1998)

Objetivo: Apresentar a experiência com a realização de revascularização do miocárdio com técnica minimamente invasiva, via minitoratocotomia anterior esquerda sem circulação extracorpórea (MIDCAB). Casuística e Métodos: 46 pacientes foram submetidos a MIDCAB de fevereiro de 1997 a janeiro de 1998. Todos eram portadores de doença obstrutiva na porção proximal do ramo interventricular anterior (RIA). A técnica consistiu em pequena incisão, de cerca de 8,0 cm, transversal, na região inframamária esquerda, obtendo-se fácil acesso para dissecção da artéria torácica interna (ATI) e posterior anastomose com o RIA. A avaliação dos resultados foi feita com controle clínico, laboratorial e angiográfico. Resultados: O tempo médio de operação foi de 2 horas, com cerca de 18 horas de internação na UTI e permanência hospitalar máxima de 5 dias. Não ocorreram óbitos intra-operatórios. Houve 1 caso de morte súbita após alta (15º PO). Os pacientes acompanhados ambulatorialmente não referiram dor anginosa. Documentou-se 4 casos de oclusão da ATI e 2 estenoses do RIA pós anastomose, provavelmente decorrentes da bandagem desse vaso durante o procedimento. Não houve correlação entre níveis de troponina-I e oclusão do enxerto. Verificou-se, porém, que os níveis de troponina I dos pacientes submetidos à MIDCAB foram significativamente menores que no procedimento convencional. Não ocorreram complicações clínicas de significância. Conclusão: A MIDCAB demonstrou ser procedimento útil e de baixa morbidade e mortalidade, com possibilidade de menor permanência hospitalar e conseqüente menor custo. Os baixos níveis sangüíneos de troponina I indicam menor sofrimento miocárdico com o procedimento.
PLASMA PROTECTIVE EFFECT ON RED BLOOD CELLS EXPOSED TO MECHANICAL STRESS (1997)

Hemodilution with plasma expanders is a widely applied practice during extracorporeal circulation and hemodialysis. Despite the immediate beneficial effects of hemodilution, such as reduction of blood viscosity and red blood cell (RBC) aggregation, elevation of blood flow in the microcirculation, etc., the dilution of plasma may cause some unfavorable effects on RBCs, amplifying the mechanical damage caused by circulatory assist devices. The authors investigated the effect of partial and total replacement of plasma on susceptibility of human and bovine RBCs to mechanical stress in vitro. Hemolysis was measured after the exposure of RBCs suspended in different media to similar mechanical stress. Experiments were performed at room temperature with control of osmolality and viscosity of the suspension media. The lowest hemolysis was obtained for RBCs suspended in serum, plasma, and albumin solutions. Hemolysis in PBS and Dextran suspensions was more than three times higher than that in plasma (p < 0.001). The protective effect depended upon protein concentration. Human RBCs were found to be significantly more sensitive to mechanical stress than bovine RBCs in all investigated suspension media (p < 0.005). Human RBCs from men suspended in plasma were found to be significantly (p < 0.05) more fragile than RBCs from women. The presence of even small amounts of plasma (such as 25%) in the suspension media significantly (p < 0.001) decreased hemolysis. However, a 30% replacement of plasma with PBS or Dextran solutions caused a statistically significant (p < 0.001) increase in mechanical hemolysis. This suggests that a decrease in the concentration of plasma proteins due to hemodilution may elevate blood damage during extracorporeal circulation and hemodialysis.
Instantaneous Power and Threshold in Continuous Wave Quantum Cascade Lasers (2009)

Using low-duty cycle pulses superimposed on a DC current, we determine the type of power roll-over and obtain the instantaneous threshold current, current efficiency and core temperature of a quantum-cascade laser in continuous wave operation.
P4–277: Targeting Aβ oligomers in Alzheimer's disease transgenic mice carrying the Arctic and Swedish mutations (2006)

It is believed that soluble Aβ oligomers, and not the extracellular insoluble Aβ deposits, are responsible for the neurotoxicity in Alzheimer's disease (AD). The Arctic APP mutation supports this idea as it enhances the formation of large soluble Aβ oligomers (known as Aβ protofibrils) in vitro (Nilsberth et al., Nat Neurosci, 2001). Despite extensive research on Aβ oligomerization, it is still unclear how well experimental findings reflect the in vivo situation in AD. An improved animal model is therefore important for the understanding of Aβ oligomers and to evaluate them as a therapeutic target. The aim is to immunologically target intraneuronal Aβ aggregates seen in our AD model and to evaluate the efficacy of monoclonal antibodies targeting linear and conformation dependent epitopes of Aβ. We have previously generated a novel transgenic mouse model, APP–ArcSwe, where the Arctic (E693G) and Swedish (K670N, M671L) APP mutations have been combined to get a model rich in Aβ oligomers (Lord et al., Neurobiol Aging, 2006). We are now using an invasive experimental setting where different Aβ antibodies are injected into the brain parenchyma of APP–ArcSwe and APP–Swe transgenic mice. This allows efficacy to be evaluated within 72 hrs. Biochemical and histological Aβ analyses of brains from 2–months–old APP–ArcSwe transgenic mice suggest a substantial presence of soluble Aβ aggregates. The transgenic mice also display early amyloidosis with appearance of senile plaques already at 5–6 months of age. Preliminary data indicate that intracranial injections with an Aβ protofibril selective monoclonal antibody reduce Aβ pathology in APP–ArcSwe and APP–Swe transgenic mice.
Hsp90 inhibition ameliorates CD4<sup>+</sup> T cell‐mediated acute Graft versus Host disease in mice (2016)

Our data, thus, suggest that Hsp90 inhibition might constitute a novel approach to reduce aGvHD in patients without abrogating the desired GvT effect.
Kallikrein-related Peptidase-8 (KLK8) Is an Active Serine Protease in Human Epidermis and Sweat and Is Involved in a Skin Barrier Proteolytic Cascade (2010)

Kallikrein-related peptidase-8 (KLK8) is a relatively uncharacterized epidermal protease. Although proposed to regulate skin-barrier desquamation and recovery, the catalytic activity of KLK8 was never demonstrated in human epidermis, and its regulators and targets remain unknown. Herein, we elucidated for the first time KLK8 activity in human non-palmoplantar stratum corneum and sweat ex vivo. The majority of stratum corneum and sweat KLK8 was catalytically active, displaying optimal activity at pH 8.5 and considerable activity at pH 5. We also showed that KLK8 is a keratinocyte-specific protease, not secreted by human melanocytes or dermal fibroblasts. KLK8 secretion increased significantly upon calcium induction of terminal keratinocyte differentiation, suggesting an active role for this protease in upper epidermis. Potential activators, regulators, and targets of KLK8 activity were identified by in vitro kinetic assays using pro-KLK8 and mature KLK8 recombinant proteins produced in Pichia pastoris. Mature KLK8 activity was enhanced by calcium and magnesium ions and attenuated by zinc ions and by autocleavage after Arg(164). Upon screening KLK8 cleavage of a library of FRET-quenched peptides, trypsin-like specificity was observed with the highest preference for (R/K)(S/T)(A/V) at P1-P1'-P2'. We also demonstrated that KLK5 and lysyl endopeptidase activate latent pro-KLK8, whereas active KLK8 targets pro-KLK11, pro-KLK1, and LL-37 antimicrobial peptide activation in vitro. Together, our data identify KLK8 as a new active serine protease in human stratum corneum and sweat, and we propose regulators and targets that augment its involvement in a skin barrier proteolytic cascade. The implications of KLK8 elevation and hyperactivity in desquamatory and inflammatory skin disease conditions remain to be studied.
Sustainable green catalysis by supported metal nanoparticles (2009)

The recent progress of sustainable green catalysis by supported metal nanoparticles is described. The template synthesis of metal nanoparticles in ordered porous materials is studied for the rational design of heterogeneous catalysts capable of high activity and selectivity. The application of these materials in green catalytic processes results in a unique activity and selectivity arising from the concerted effect of metal nanoparticles and supports. The high catalytic performances of Pt nanoparticles in mesoporous silica is reported. Supported metal catalysts have also been applied to biomass conversion by heterogeneous catalysis. Additionally, the degradation of cellulose by supported metal catalysts, in which bifunctional catalysis of acid and metal plays the key role for the hydrolysis and reduction of cellulose, is also reported.
A Facile Approach of Fabricating Ultra-Thin Wear Resistant Si/SiNx/C Overcoats for Magnetic Tape Recording Heads (2014)

Magnetic tape recording is one of the oldest data storage technologies, and it is still used today due to its low cost and long data storage life. Magnetic tape recording is a contact recording technology, where a thin flexible magnetic tape medium is pulled across an Al2O3/TiC (AlTiC) recording head surface at a high velocity while in direct physical contact with each other. As a result, one of the inherent problems faced in magnetic tape recording systems is an increase in the magnetic spacing over time with prolonged usage, due to continuous wear of the tape bearing head surface, which in turn leads to a deterioration of the magnetic readback signal [1]. The increase in the magnetic spacing at the head-tape interface can be due to several factors, such as pole tip recession (PTR), accumulation of wear debris on the head and surface roughness of the head and tape medium. Out of these factors, PTR is a major contributor to the magnetic spacing loss, due to a higher rate of wear of the softer magnetic read and write poles at the head-tape interface [2].