gebhart/patrepeval huggingface dataset:
The effect of electrostatic screening of Rogowski coils designed for wide-bandwidth current measurement in power electronic applications (2004)

Rogowski current transducers are ideal for monitoring pulsed and transient currents in power electronic applications as they have a high bandwidth and low insertion impedance. It is sometimes necessary to fit an electrostatic shield to the Rogowski coil. Large dV/dt disturbances in close proximity to the coil produce measurement interference due to capacitive coupling. A shield eliminates this coupling. However Rogowski coils are not normally fitted with an electrostatic shield since the resulting increase in coil capacitance reduces the high frequency bandwidth. Also the coil is bulkier, less flexible and more difficult to manufacture. There are applications where local dV/dt disturbances are so large that fitting a screen is a necessity. This paper examines the compromise between the high frequency performance of the Rogowski transducer and the effective electrostatic shielding of dV/dt interference. A theoretical model for the mechanism by which large close coupled sources of dV/dt affect the behaviour of the Rogowski coil is presented. In addition the paper describes a model for the high frequency performance of a shielded Rogowski coil. These models are verified using a purpose built test rig capable of generating large dV/dt disturbances in excess of 40 kV/us.
Onium salt reduces the inhibitory polymerization effect from an organic solvent in a model dental adhesive resin (2007)

This study evaluated the effect of organic solvent concentration on the polymerization kinetics for a model dental adhesive resin containing a ternary photoinitiator system. A monomer blend based on the bis-GMA, TEGDMA, and HEMA was used as a model dental adhesive resin, which was polymerized using a binary system [camphorquinone (CQ) and ethyl 4-dimethylamine benzoate (EDAB)] and a ternary system [CQ, EDAB, and diphenyliodonium hexafluorphosphate (DPIHFP)]. Additionally, these blends had 0, 10, 20, 30, and 40 wt % ethanol added. Real-time Fourier transform infrared spectroscopy was used to investigate the polymerization reaction over photoactivation time. Data were plotted, and Hill's three-parameter nonlinear regression was performed for curve fitting. The addition of a solvent to the monomer blends decreased the polymerization kinetics, directly affecting the rate of polymerization, delaying vitrification, and attenuating the Trommsdorf effect. The introduction of DPIHFP displayed a strong increase in reaction kinetics, reducing the solvent inhibition effect. After 10 s of photoactivation, the binary system obtained in 0, 10, 20, 30, and 40% of ethanol, a degree of conversion of 44.6, 26.3, 13.4, 1.15, and 0.0%, respectively, whereas when a ternary system was used, the values were 54.6, 40.5, 27.4, 14.5, and 3.4%. An improvement was observed in the polymerization kinetics of a model dental adhesive resin when using a ternary photoinitiation system, making the material less sensitive to the residual presence of a solvent before photoactivation.
A SPAD array sensor based on breakdown pixel extraction architecture with background readout for scintillation detector (2017)

This paper proposes a SPAD array sensor based on breakdown pixel extraction architecture with background readout for scintillation detectors. The proposed architecture extracts the addresses of only the breakdown pixels during the exposure time of the next frame. Therefore, this sensor minimizes the dead time and improve the readout efficiency. A SPAD array sensor was fabricated in a 0.18 μm CMOS process. According to the measurement results under the dark condition, the duty cycle of the exposure time is 1.25 times higher than the previous work. This high duty cycle improves the probability to detect the incident photons occurring closely in time and achieves an efficient event detection.
Supplementary Figure 5 from Immune-Based Antitumor Effects of BRAF Inhibitors Rely on Signaling by CD40L and IFNγ (2023)

&lt;p&gt;PDF file - 511KB, Supplementary Figure 5. PLX4720 treatment inhibits melanoma growth is independent of CD70.&lt;/p&gt;
Contribution à l'étude et à la réalisation d'un générateur de signaux radiofréquences analogiques pour la radio logicielle intégrale (2015)

Une utilisation intelligente de l’espace Hertzien sera nécessaire pour permettre aunombre croissant d’objets sans-fil connectés de communiquer dans le même espace de propagation.Ces travaux de thèse proposent une architecture d’émetteur radiofréquence flexible, faiblecoût et faible consommation, en rupture avec les techniques conventionnelles. Cet émetteur estfondé sur un encodage de la dérivée du signal à générer, ce qui permet de réduire le coût énergétiquede la conversion de l’information. Un convertisseur numérique analogique compatibleavec cette architecture est présenté et ses performances sont évaluées dans le cadre de la générationde signaux radiofréquence. Les résultats de mesures obtenus avec un prototype réalisé entechnologie CMOS 65 nm apporte la preuve du concept.
Rapid Testing of CRISPR Nucleases and Guide RNAs in an E. coli Cell-Free Transcription-Translation System (2020)

We present a protocol to rapidly test DNA binding and cleavage activity by CRISPR nucleases using cell-free transcription-translation (TXTL). Nuclease activity is assessed by adding DNA encoding a nuclease, a guide RNA, and a targeted reporter to a TXTL reaction and by measuring the fluorescence for several h. The reactions, performed in a few microliters, allow for parallel testing of many nucleases and guide RNAs. The protocol includes representative results for (d)Cas9 from <i>Streptococcus pyogenes</i> targeting a GFP reporter gene. For complete information on the generation and use of this protocol, please refer to the paper by Marshall et al. (2018).
A network analysis of executive functions before and after computerized cognitive training in children and adolescents (2022)

Executive functions (EFs) play a key role in cognitive and socioemotional development. Factor analyses have revealed an age dependent structure of EFs spanning from a single common factor in early childhood to three factors in adults corresponding to inhibitory control (IC), switching and updating. IC performances change not only with age but also with cognitive training. Surprisingly, few studies have investigated training-related changes in EFs structure. We used the regularized partial correlation network model to analyze EFs structure in 137 typically developing children (9-10 years) and adolescents (15-17 years) before and after computerized cognitive training. Network models (NMs) -a graph theory-based approach allowing us to describe the structure of complex systems- can provide a priori free insight into EFs structures. We tested the hypothesis that training-related changes may mimic developmental-related changes. Quantitative and qualitative changes were detected in the EFs network structure with age and also with cognitive training. Of note, the EFs network structure in children after training was more similar to adolescents' networks than before training. This study provided the first evidence of structural changes in EFs that are age and training-dependent and supports the hypothesis that training could accelerate the development of some structural aspects of EFs. Due to the sample size, these findings should be considered preliminary before replication in independent larger samples.
2A1-J05 Assembly of an artificial bionic nano-machine based on cellular nano system : Self-organization by designed cell migration using bio-hybrid micro device (2009)

Cell driven construction of bionic nano/micro systems had been conceptualized to embed biological self-contain nano mechanochemical systems in nano machine. Cell skeletal filaments are controlled by membrane protein reactions which are related to interaction between these and external bioactive patterns with nanostructures. So, we evaluated the migration behavior on various pattern of MPC treatment. The liner pattern performed higher deviation of displacements in cell migration than the circular pattern. These cellular behaviors would contribute controlling of molecular reaction driven nano assembly mechanism in the biological molecular system of cells.
Microfluidic Droplet Method for Nucleation Kinetics Measurements (2008)

In this work, we developed a microfluidic equivalent of the classical droplet method for investigating nucleation kinetics. Our microfluidic device allows us to store hundreds of droplets of small volume ( approximately 100 nL) and to accurately control their temperature. We also monitor directly all the stored droplets, and thus perform statistical measurements on a large number of nucleation events. In the case of aqueous solutions of potassium nitrate, we manage to investigate nucleation kinetics and polymorphs and quantify the influence of impurities. The use of small droplets is crucial in such experiments, since it allows the sample to reach high supersaturations and to separate all the nucleation events. Moreover, we compare our results to the classical nucleation theory, and we demonstrate unambiguously using direct observations of the droplets that nucleation in aqueous solutions of potassium nitrate always occurs using heterogeneous mechanisms.
A comparison of the Berenger perfectly matched layer and the Lindman higher-order ABC's for the FDTD method (1995)

Higher-order absorbing boundary conditions are compared to the recently introduced Berenger perfectly matched layer (PML) absorbing boundary conditions (ABC). Reflections caused by the ABC's are examined in both the time and frequency domains for the case of a line source radiating in a finite computational domain. It is shown that the PML ABC significantly reduces reflections from the truncation of the computational grid when compared to 7th order Lindman ABC's. Also, except for at low frequencies, higher-order absorbing boundary conditions are no better than 2nd order Mur absorbing boundaries.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Fig. S10 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Evaluating the effects of shRNA vector, PAFR shRNA, Stat3 shRNA, or these shRNAs in the presence of 100 nM PAF on the mRNA level of IL-6 in A549 and H460 cells.&lt;/p&gt;
Measurement techniques for studying the dielectric permittivity of lossy ceramic composites used in vacuum electronics (2002)

Improved techniques and specialized systems for performing measurements of the complex dielectric permittivity of ceramic materials from 26.5-40 GHz over the -185 to +250/spl deg/C temperature range have been developed. The methodology is intended primarily to measure the dielectric properties of lossy ceramics used in vacuum electronic devices, such as BeO-SiC and AlN-SiC. The elevated temperature studies are needed to ascertain how the dielectric properties will change over the conditions known to exist in high average power devices, while the low temperature capability is important for understanding the competing mechanisms of dielectric loss in the materials themselves. Although the present work has concentrated on Ka-Band, the techniques are general and can be replicated in other frequency ranges.
Metal-Mediated Peptide Ion Conformations in the Gas Phase (2000)

The influence of metal cations and source temperature on the conformations of oxidized insulin chain A (ICA) anions has been investigated in the gas phase by high-resolution ion mobility techniques. Cross sections for non-metalated [ICA-nH]n- (n = 2−6) ions show a distinct Coulomb-driven unfolding transition when four or more protons are removed. Studies of [ICA-6H + M2+]4- ions (where M = Ca, Mn, Co, Ni, Cu, or Zn) show that metal peptide ions favor specific types of conformations that depend upon the binding properties of the metal. Doubly-charged metal ions appear to bind to multiple sites (presumably through interactions with −SO3-, −COO-, and amide groups on various amino acids) and have a pronounced effect on the number and shapes of stable conformations. Generally, [ICA-6H + M2+]4- ions are found to be more compact than their [ICA-4H]4- analogues. Studies of [ICA-5H + Na+]4- ions show that addition of Na+ to the ICA anion has little effect on the peptide structure. The relative stabilities of different conformations for different metal ions are discussed in terms of simple qualitative potential energy surfaces.
Unbiased screen for pathogens in human paraffin-embedded tissue samples by whole genome sequencing and metagenomics (2022)

Identification of bacterial pathogens in formalin fixed, paraffin embedded (FFPE) tissue samples is limited to targeted and resource-intensive methods such as sequential PCR analyses. To enable unbiased screening for pathogens in FFPE tissue samples, we established a whole genome sequencing (WGS) method that combines shotgun sequencing and metagenomics for taxonomic identification of bacterial pathogens after subtraction of human genomic reads. To validate the assay, we analyzed more than 100 samples of known composition as well as FFPE lung autopsy tissues with and without histological signs of infections. Metagenomics analysis confirmed the pathogenic species that were previously identified by species-specific PCR in 62% of samples, showing that metagenomics is less sensitive than species-specific PCR. On the other hand, metagenomics analysis identified pathogens in samples, which had been tested negative for multiple common microorganisms and showed histological signs of infection. This highlights the ability of this assay to screen for unknown pathogens and detect multi-microbial infections which is not possible by histomorphology and species-specific PCR alone.
ChemInform Abstract: 4‐Aryl‐6,6‐dimethyl‐1,2,3,4,5,6,7,8‐octahydroquinazoline‐2,5‐diones: Synthesis, Chromatographic Resolution and Pharmacological Activity. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Deciphering the chronology of copy number alterations in Multiple Myeloma (2019)

Multiple myeloma (MM) and its precursor condition MGUS are characterized by chromosomal aberrations. Here, we comprehensively characterize the order of occurrence of these complex genomic events underlying MM development using 500 MGUS, and MM samples. We identify hyperdiploid MM (HMM) and non-HMM as genomically distinct entities with different evolution of the copy number alterations. In HMM, gains of 9,15 or 19 are the first and clonal events observed as clonal even at MGUS stage. These events are thus early and may underlie initial transformation of normal plasma cells to MGUS cells. However, CNAs may not be adequate for progression to MM except in 15% of the patients in whom the complex subclonal deletion events are observed in MM but not MGUS. In NHMM, besides the driver translocations, clonal deletion of 13 and 1q gain are early events also observed in MGUS. We combined this information to propose a timeline for copy number alteration.
Vertical Protection Level Equations for Dual Frequency SBAS (2010)

The L1-only Satellite-Based Augmentation System (SBAS) Minimum Operational Performance Standards (MOPS) were developed long before any SBASs were certified for operation. During the development and certification of the Wide Area Augmentation System (WAAS), it was discovered that the zero-mean Gaussian basis of the Vertical Protection Level (VPL) equation was not strictly true for some error sources, and very difficult to sufficiently demonstrate for others. The actual data collected in support of system performance demonstrated non-Gaussian behavior. Further, sources of small uncorrectable biases were discovered after the original MOPS development. These biases can arise from consistent, minor differences in the signal structure from one satellite to another. Antenna biases at the satellite, at the reference stations, and at the user are other possible sources of these biases. Because the MOPS VPL equation is based upon zero-mean Gaussian error combination, much additional work was required to demonstrate that the actual errors could be sufficiently protected safely. Some performance is lost because the system has to implement conservative approaches to account for these discrepancies. 
The advent of dual frequency SBAS affords the opportunity to revisit the MOPS and use different approaches for this new class of user. Lessons learned from the L1-only system certification and operation can be leveraged to both ease development of the future dual frequency system and improve user performance. This paper examines the VPL equations and proposes changes to directly address these lessons. The handling of non- Gaussian behavior and small biases directly address both goals. The VPL can be further changed to directly address the threats that most limit availability. Without the corrupting influence of the ionosphere, satellite faults become the dominant source of significant error. New VPL equations are proposed to specifically account for individual satellite fault modes. This paper will demonstrate that by avoiding overly conservative steps required to handle all possible cases, the users will see reduced protection levels and higher availability.
Fast and robust CD and DGD estimation based on data-aided channel estimation (2011)

In this paper data-aided (DA) frequency domain (FD) channel estimation in a 2×2 multi-input-multi-output (MIMO) system is investigated. Using orthogonal training sequences, fast and robust CD and DGD estimation is demonstrated for a 112 Gbit/s PDM-QPSK system over a wide range of combined linear channel impairments.
Persistent Increase in Serum Ferritin Levels despite Converting to Permanent Vascular Access in Pediatric Hemodialysis Patients: Pediatric Nephrology Research Consortium Study (2023)

Our objective was to examine serum ferritin trends after conversion to permanent vascular access (PVA) among children who started hemodialysis (HD) using tunneled cuffed catheters (TCC). Retrospective chart reviews were completed on 98 subjects from 20 pediatric HD centers. Serum ferritin levels were collected at the creation of PVA and for two years thereafter. There were 11 (11%) arteriovenous grafts (AVG) and 87 (89%) arteriovenous fistulae (AVF). Their mean TCC use was 10.4 ± 17.3 months. Serum ferritin at PVA creation was elevated at 562.64 ± 492.34 ng/mL, increased to 753.84 ± 561.54 ng/mL (<i>p</i> = < 0.001) in the first year and remained at 759.60 ± 528.11 ng/mL in the second year (<i>p</i> = 0.004). The serum ferritin levels did not show a statistically significant linear association with respective serum hematocrit values. In a multiple linear regression model, there were three predictors of serum ferritin during the first year of follow-up: steroid-resistant nephrotic syndrome as primary etiology (<i>p</i> = 0.035), being from a center that enrolled >10 cases (<i>p</i> = 0.049) and baseline serum ferritin level (<i>p</i> = 0.017). Increasing serum ferritin after conversion to PVA is concerning. This increase is not associated with serum hematocrit trends. Future studies should investigate the correlation of serum transferrin saturation and ferritin levels in pediatric HD patients.
Evolution of anterior pituitary functions after selective removal of pituitary microadenomas in Cushing's disease (1979)

SCOPUS: NotDefined.j
The Transcriptional Coactivator p300 Plays a Critical Role in the Hypertrophic and Protective Pathways Induced by Phenylephrine in Cardiac Cells but Is Specific to the Hypertrophic Effect of Urocortin (2004)

Anacardic acid is an alkylsalicylic acid obtained from cashew-nut-shell liquid, and is a potent inhibitor of p300 histone acetyl-transferase (HAT) activity. We have used anacardic acid to prevent the induction of hypertrophy in isolated neonatal rat cardiomyocytes. Hypertrophy was detected as an increase in cell size, the rearrangement of sarcomeres into a striated pattern, and the induction of embryonic genes beta-MHC and ANF. p300 inhibition was equally effective at preventing hypertrophy whether it was induced by treatment with the alpha1-adrenergic agonist, phenylephrine, or by treatment with urocortin, a member of the corticotrophin-releasing-factor family, which stimulates specific G protein-coupled receptors. Spiruchostatin A is a natural-product inhibitor of histone deacetylases (HDAC) similar to the depsipeptide FK228 molecule. We have recently synthesized spiruchostatin A and now show that, although HDACs act in opposition to HATs, spiruchostatin A has the same effect as anacardic acid, that is, it prevents the induction of hypertrophy in response to phenylephrine or urocortin. Pretreatment with either phenylephrine or urocortin reduced the extent of death observed after the exposure of isolated cardiomyocytes to simulated ischaemia and reoxygenation. Inhibition of p300 or HDAC activity eliminated the protection conferred by phenylephrine; however, it did not affect the protection conferred by urocortin. Therefore, it might eventually be possible to use chemical inhibitors such as these in a therapeutic setting to dissociate the protective effect and hypertrophic effect of urocortin, enhancing the survival of cardiomyocytes exposed to transient ischemia, while inhibiting the hypertrophic pathway that would otherwise be induced concurrently.
Listeriolysin S, a Novel Peptide Haemolysin Associated with a Subset of Lineage I Listeria monocytogenes (2008)

Streptolysin S (SLS) is a bacteriocin-like haemolytic and cytotoxic virulence factor that plays a key role in the virulence of Group A Streptococcus (GAS), the causative agent of pharyngitis, impetigo, necrotizing fasciitis and streptococcal toxic shock syndrome. Although it has long been thought that SLS and related peptides are produced by GAS and related streptococci only, there is evidence to suggest that a number of the most notorious Gram-positive pathogenic bacteria, including Listeria monocytogenes, Clostridium botulinum and Staphylococcus aureus, produce related peptides. The distribution of the L. monocytogenes cluster is particularly noteworthy in that it is found exclusively among a subset of lineage I strains; i.e., those responsible for the majority of outbreaks of listeriosis. Expression of these genes results in the production of a haemolytic and cytotoxic factor, designated Listeriolysin S, which contributes to virulence of the pathogen as assessed by murine- and human polymorphonuclear neutrophil-based studies. Thus, in the process of establishing the existence of an extended family of SLS-like modified virulence peptides (MVPs), the genetic basis for the enhanced virulence of a proportion of lineage I L. monocytogenes may have been revealed.