gebhart/patrepeval huggingface dataset:
Impaired response of neutrophils to a lymphokine by sera from patients with connective tissue disease (1983)

The studies reported here were designed to determine whether sera from various patients could prevent neutrophils from responding to the lymphokine, neutrophil migration inhibition factor from T lymphocytes (NIF-T). Neutrophils from healthy donors were treated with sera from 84 subjects and assayed for responses to NIF-T. Serum from 7 of 37 patients (19%) with rheumatoid arthritis, systemic lupus erythematosus, and various forms of vasculitis showed blocking activity. In contrast, none of 47 subjects, including healthy individuals and patients with spondylarthropathies, cancer, and active infections had a serum factor that prevented neutrophils from responding to NIF-T (P less than 0.01). Serum blocking activity occurred transiently in association with infection by Staphylococcus aureus in one patient with rheumatoid arthritis. Moreover, autologous neutrophils from this same patient showed impaired responses to NIF-T. Blocking activity could be eluted from protein A-Sepharose in three of three patients studied. In three of seven patients, blocking activity was detected in serum cryoprecipitates, with a recovery of 46 to 78% of the blocking activity and overall enrichment (purification) of 137- to 281-fold. Analysis of cryoprecipitates by sodium dodecyl sulfate-polyacrylamide gel electrophoresis showed the predominance of immunoglobulins M and G. In one patient, the serum blocking activity was not cryoprecipitable, and cryoprecipitates from a patient with essential cryoglobulinemia failed to prevent neutrophils from responding to NIF-T. Blocking activity was relatively specific for NIF-T, as there was no effect on F-met-leu-phe-induced chemotaxis of neutrophils. Serum blocking activity in patients with connective tissue disease showed some correlation (r = 0.50; P less than 0.01) with immune complexes detected by polyethylene glycol precipitation but not Clq binding. These studies suggest that the response of neutrophils to NIF-T may be blocked by serum, possibly as a result of immune complexes or autoantibodies found primarily in patients with connective tissue disease.
Instruction cache aging mitigation through Instruction Set Encoding (2016)

The reliability of embedded processors fabricated using nanoscale technology nodes is threatened by accelerated transistor aging particularly, Bias Temperature Instability (BTI). In embedded memories such as instruction caches, BTI degrades the Static Noise Margin (SNM) of the memory cell, which in turn affects the stability of the stored value. Various bit flipping based solutions have been proposed to address BTI-induced aging of memory components. Nevertheless, the state-of-the-art techniques have considerable area and power overheads. In this paper, we propose an aging-aware instruction encoding technique to mitigate BTI-induced aging of instruction caches. Opcode, register and function code fields of an instruction are re-encoded so that the BTI-induced aging of the instruction cache is minimized. Simulation results show that the proposed technique achieves up to 40% SNM degradation improvement (equivalent to 47% MTTF improvement) with a negligible power overhead (0.1%).
Nanoscale glycan organization in A549 cells. (2020)

&lt;p&gt;A549 cells were fixed, labelled using SNA and imaged with STED. We found a similar glycan organization of small clusters as well as protruding microvilli as visualized with STORM (&lt;b&gt;A&lt;/b&gt;). A similar glycan organization was observed using SNA on MDCK cells (&lt;b&gt;B&lt;/b&gt;). We also labelled A549 cells with wheat germ agglutinin (WGA), which unlike SNA, less specifically labels all sialylated glycans (&lt;b&gt;C&lt;/b&gt;). Using WGA, we could reproduce the nanocluster compartmentalization of the cell surface as well as protruding hollow microvilli (arrow heads in &lt;b&gt;C&lt;/b&gt;, right panel).&lt;/p&gt; &lt;p&gt;(PDF)&lt;/p&gt;
Sleep mode operations with relaxed and stringent QoS requirements (2015)

Binary-exponential sleep mode (BE-SM) operation is an energy-saving solution of mobile stations for best-effort or non-realtime services. In general, there is a trade-off between energy consumption and delay. Especially, in the conventional BE-SM operations, the standard scheme achieves the lower bound of delay, while the threshold scheme achieves the upper bound of delay. Since the threshold scheme yields the highest energy efficiency at the expense of delay, it does not guarantee given quality-of-service (QoS) requirements. From the viewpoint of various QoS requirements, we propose a relaxed QoS (RQ) scheme with relaxed QoS requirements and a stringent QoS (SQ) scheme with stringent QoS requirements in which we have two policies: additional sleep cycles and buffer-threshold. The results show that the proposed RQ scheme has a trade-off between energy efficiency and user satisfaction ratio at low arrival rate, while the proposed SQ scheme is close to the upper bound of energy efficiency while satisfying the stringent QoS requirements.
Epidemiology of SARS-CoV-2 infection in Italy using real-world data: methodology and cohort description of the second phase of web-based EPICOVID19 study (2022)

ABSTRACT Digital technologies have been extensively employed in response to the SARS-CoV-2 pandemic worldwide. This study describes the methodology of the two-phase internet-based EPICOVID19 survey, and the characteristics of the adult volunteers respondents who lived in Italy during the first (April - May 2020) and the second wave (January - February 2021) of the epidemic. Validated scales and ad-hoc questionnaires were used to collect socio-demographic, medical and behavioural characteristics, as well as information on COVID-19. Among those who provided email addresses during phase I (105,355), 41,473 participated in phase II (mean age 50.7 years ± 13.5 SD, 60.6% females). After a median follow-up of ten months, 52.8% had undergone naso-pharyngeal swab (NPS) testing and 13.2% had positive result. More than 40% had undergone serological test (ST) and 11.9% were positive. Out of the 2,073 participants with at least one positive ST, 72.8% had only negative results from NPS or never performed it. These results indicate that a large fraction of individuals remained undiagnosed, possibly contributing to the spread of the virus in the community. Participatory online surveys offer a unique opportunity to collect relevant data at individual level from large samples during confinement.
Single-channel 200 Gbit/s, 10 Gsymbol/s-1024 QAM injection-locked coherent transmission over 160 km with a pilot-assisted adaptive equalizer (2018)

We demonstrate a 10 Gsymbol/s, 1024 quadrature amplitude modulation (QAM) 160 km coherent transmission with an injection locking technique. Our newly developed, pilot-assisted adaptive equalizer has greatly improved the precision of waveform distortion compensation, and this has enabled us to increase the symbol rate to 10 Gsymbol/s in a 1024 QAM transmission. Thus, we could realize a 200 Gbit/s, 1024 QAM transmission over 160 km with a potential spectral efficiency of 12.6 bit/s/Hz.
High-speed nanoscale optical trapping with plasmonic double nanohole aperture (2023)

Optical trapping with plasmonic double nanohole (DNH) apertures has proven to be an efficient method for trapping sub-50 nm particles due to their suppressed plasmonic heating effect and very high electric field enhancement in the gap region of the aperture. However, plasmonic tweezers are generally diffusion-limited, requiring particles to diffuse down to a few tens of nanometres from the high field enhancement regions before they can be trapped. The loading of target particles to the plasmonic hotspots can take several minutes for diluted samples. In this work, rapid particle transport and trapping of a 25 nm polystyrene sphere is demonstrated, leveraging an electrothermoplasmonic flow induced upon application of an AC field in the presence of a laser-induced temperature gradient. Using this approach, we demonstrate the rapid transport of a 25 nm polystyrene particle across a distance of 63 μm and trapping at the DNH under 16 s. This platform shows great potential for applications involving simultaneous trapping and plasmon-enhanced spectroscopies, such as Raman enhancement <i>via</i> the intense electric field enhancement in the DNH gap.
Textured Sc-Doped Barium–Ferrite Compacts for Microwave Applications Below 20 GHz (2006)

Sc is substituted for Fe in Ba M-type hexaferrite to reduce the anisotropy field and shift the ferromagnetic resonance (FMR) frequency to below 20 GHz. We have produced pure phase BaFe <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$_11$</tex> ScO <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$_19$</tex> powders having a platelet microstructure. These materials are pressed under an applied magnetic field of 95.5 <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$times$</tex> 10 <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$^5$</tex> A/m. Resulting compacts are sintered and are shown to have a clear uniaxial anisotropy with the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$c$</tex> -axis perpendicular to the surface plane. Hysteresis loops display a squareness of 0.83 with a coercivity of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$sim $</tex> 186 kA/m. The <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$X$</tex> -band FMR power derivative linewidth is measured to be 79.6 kA/m.
Synthesis of an iron silicate with the ferrierite structure (1996)

R. B. Borade and A. Clearfield, Chem. Commun., 1996, 2267 DOI: 10.1039/CC9960002267
Base-Transposed Chiral Isomeric Nucleosides (1995)

Abstract The synthesis and anti-HIV activities of a number of new analogues of basetransposed chiral isomeric nucleosides are described. Modifications of the anti-HIV active compound, (S,S)-isodideoxyadenosine, included both the base and carbohydrate regions.
High-Efficiency Tandem Absorbers for Economical Solar Hydrogen Production (2019)

The objective of this project is to develop a semiconductor-based device capable of over 20% solar-to-hydrogen efficiency with several thousand hours of stability under operating conditions. The ultimate system design will incorporate electrode components that can be fabricated cost-effectively and do not present a barrier to scale-up. Solar-to-hydrogen efficiency will be improved from our world-record holding 12.4% to over 20% by developing novel tandem semiconductor materials and configurations. Our approach focuses on classes of materials that have either demonstrated exceptionally high efficiency or theoretically can produce highly efficient materials. The four tandem-material approaches we will take are: III-Vs on GaAs, InGaN on Si, III-V-N on Si, and dual photoelectrode pairings. Durability will be enhanced from a few hundred hours to nearly 1000 hours, with a stretch target of 3500 hours, through catalytic nitride, oxide, and sulfide-based semiconductor surface modifications. Economical hydrogen production is attainable using high-efficiency III-V photoelectrochemical materials with cost reductions from emerging epitaxial synthesis technologies such as spalling, epitaxial lift-off, or close-space vapor transport. We will address synthesis cost, in a limited capacity, by investigating novel material configurations. The expected outcome is a prototype photoreactor that produces 3 L of standard hydrogen within an 8-hour period under moderate solar concentration (10x), which can be accomplished using only 6 cm2 of a 20% STH material. Inputting attainable performance metrics from our approach into the H2A Central Production Model 3.0 shows a clear pathway to hydrogen production cost of <$2/gge.
ChemInform Abstract: Copper‐Catalyzed/Promoted Cross‐Coupling of gem‐Diborylalkanes with Nonactivated Primary Alkyl Halides: An Alternative Route to Alkylboronic Esters. (2015)

Abstract The reaction tolerates various electrophiles in form of primary alkyl bromides, iodides, tosylates, and even phosphoric acid esters equipped with a variety of substituents, such as alkyl, alkenyl, aryl, hetaryl, chloro, alkoxy, silyloxy, phthalimido and amino acid moieties.
Analysis of IPT Intermediate Coupler System for Vehicle Charging Over Large Air Gaps (2021)

Intermediate resonant pads have been recently used to increase the ground clearance for inductive power transfer (IPT) systems transferring power over large air gaps. This article investigates the best placement of a tuned intermediate pad to maximize the air gap by assessing the leakage magnetic fields and the apparent power effort. A mathematical analysis is used to design and control a two-coil system with an intermediate pad. The results show that SAE J2954 standard pads can transfer rated power over an extended air gap of 406 mm using an intermediate pad while adhering to the apparent power ratings of all pads and typical leakage constraints. As a comparison, an equivalent IPT system using only a primary and a secondary pad without the intermediate pad is shown to be unable to meet the apparent power and leakage requirements at these large air gaps. Additionally, this article shows and validates control and regulation of the intermediate pad and load current by switching the secondary side.
Association of number of follow-up providers with outcomes in survivors of hematologic malignancies (2010)

Studies examining follow-up care among cancer survivors have increased in number, and are mostly focused on who best provides care. It is not known whether having single or multiple physicians as follow-up providers has outcome implications. We prospectively studied the association between number of follow-up providers among survivors of hematologic malignancies and serious medical utilization (defined as emergency room visits or hospitalizations) within a 6-month period. Patients completing treatment (n&#x2009;=&#x2009;314) were included. Patients seeing multiple follow-up providers were more likely to be younger, to reside farther away from the university hospital, to have prescription drug insurance, to have received prior cancer treatment, to have multiple myeloma, and to have undergone hematopoietic cell transplant as a part of cancer treatment. Multivariate analysis showed that the number of follow-up providers was not associated with serious medical utilization (odds ratio 1.29, 95% confidence interval 0.68&#x2013;2.48, p&#x2009;=&#x2009;0.44) after adjusting for patient factors. Our study showed that among survivors of hematologic malignancies, outcomes were not different for survivors who were seen by single or multiple follow-up providers.
Toward a Structure−Activity Relationship for Apoptolidin:  Selective Functionalization of the Hydroxyl Group Array (2003)

[reaction: see text] To investigate the structural basis for the exceptional selectivity and activity of apoptolidin (1), a strategy has been devised that allows for selective functionalization of seven of its eight hydroxyl groups based on progressive silyl protection, derivatization, and deprotection. The syntheses of these derivatives and their ability to inhibit F(0)F(1)-ATPase are reported.
Femtosecond optical parametric generation (OPG) in periodically poled stoichiometric LiTaO/sub 3/ with &amp;lt;1 W average power (2003)

Summary form only given. We present a parametric generator based on the novel nonlinear material periodically poled stoichiometric LiTaO/sub 3/ (PPSLT) and a recently developed high-power femtosecond Yb:KY(WO/sub 4/)/sub 2/ (Yb:KYW) thin-disk laser. We achieved simple and robust single-pass OPG at the full repetition rate of 24 MHz. We obtained stable 1 W signal power in 320 fs-pulses with a good transverse beam quality (M/sup 2/ = 1.1) at 1.45 /spl mu/m and 0.6 W of idler power at 3.55 /spl mu/m for 7.8 W pump power. For a few minutes, even 2.5 W of signal output power have been achieved. The damage resistance of PPSLT seems to be significantly better than for congruent PPLN.
Antiviral activity and dose optimum of recombinant macrophage colony-stimulating factor on herpes simplex genitalis in guinea pigs (1991)

The antiviral activity of recombinant human macrophage CSF (M-CSF) against genital herpes simplex virus type-2 (HSV-2) infection in guinea pigs was investigated. M-CSF stimulates proliferation of human and guinea pig peripheral blood monocytes, specifically the plastic adherent esterase-positive mononuclear cells. When anti-HSV-2 activity of M-CSF was evaluated in guinea pigs by 6 daily injection (s.c.) of M-CSF at various doses (5 x 10(5) to 7 x 10(7) U/kg), we found 2 x 10(6) U/kg to be the optimum dose for protective efficacy against primary HSV-2 infection. Either at a lethal, 5 x 10(5) pfu, or sublethal 5 x 10(4) pfu of virus challenge, animals treated with the optimum regimen of M-CSF exhibited lower herpetic lesion scores (p less than 0.005), and lower mortality (p less than 0.025) than animals in placebo group. M-CSF treatment increased the HSV-infected cell killing activities of plastic-adherent mononuclear cells, indicating that in vivo administration of M-CSF may activate the antiviral effects of guinea pig macrophages that may play a role in protection against severity and mortality of herpetic disease.
FTS2‐01‐01: A LONGITUDINAL STUDY OF MID‐TO LATE‐LIFE BLOOD PRESSURE PROFILES AS RISK FACTORS FOR ALZHEIMER'S DISEASE IN HISPANICS (2018)

Abstract not available.
Mechanical Properties Evaluation of a Ti-6Al-4V Thin-Wall Structure Produced by a Hybrid Manufacturing Process (2018)

The hybrid manufacturing (HM) process combines the precision of computer numerical control (CNC) and the freeform capability of additive manufacturing to expand the versatility of advanced manufacturing. The intent of this paper is to explore the relationship between HM processing parameters and mechanical properties of the final parts manufactured by one type of HM process that combines laser metal deposition (LMD) and CNC milling. The design of experiment (DOE) is implemented to explore the Ti-6Al-4V thin-wall structure fabrication process with different HM build strategies. Vickers hardness, tensile test, and microstructure analyses are conducted to evaluate the mechanical property variance within the final parts fabricated according to the DOE matrix. Finally, a prediction model of yield strength at 0.2% offset for Ti-6Al-4V parts built through the aforementioned HM process was obtained by an analysis of variance (ANOVA) test, which revealed the significant factors are build height within each LMD process, laser energy input, and the interaction of build height within each LMD process to the preheating condition.
IC for online EIS in automotive batteries and hybrid architecture for high-current perturbation in low-impedance cells (2018)

This paper describes a new custom IC optimised for online Electrochemical Impedance Spectroscopy (EIS) characterisation of battery packs at the cell-level, with 200 mA peak perturbation current. In addition, a new hybrid power architecture is demonstrated that has been designed to be embedded in the battery management system of a new electric pick-up truck. The hybrid architecture consists of 1) a linear current regulator, 2) a small ultracapacitor, and 3) an isolated Cuk converter that is part of the balancing system, which also supplies the 12V auxiliary loads. The architecture leverages the signal processing capabilities of the IC and extends the perturbation range to 40 A peak while limiting the thermal losses. Experimental EIS measurements are performed for four parallel-connected 44 Ah Lithium Nickel-Manganese-Cobalt-oxide pouch cells, each with 1 mQ nominal internal resistance, at 40 A peak excitation current.
The effect of microvascular obstruction and intramyocardial hemorrhage on contractile recovery in reperfused myocardial infarction: insights from cardiovascular magnetic resonance (2013)

Strain improves within the infarct zone overall following reperfusion with or without MO or IMH. Mid-myocardial and endocardial infarct contractility is diminished in the presence of MO, and further in the presence of IMH. MO and IMH are greater independent predictors of infarct zone contractile recovery than infarct volume or transmural extent.
Synthesis and characterization of photoluminescent vinylbiphenyl decorated polyhedral oligomeric silsesquioxanes (2008)

Grubbs cross-metathesis has been used to functionalize octavinylsilsesquioxane with fluorescent vinylbiphenyl-modified chromophores to design new hybrid organic-inorganic nanomaterials. Those macromolecules have been characterized by NMR, microanalyses, MALDI-TOF mass spectrometry and photoluminescence. This last method was shown to be an interesting tool in the analysis of the purity of the cube derivatives.
Progress in printed organic electronics and hybrid photovoltaics (2005)

We will discuss patterning of conducting polymers using ink jet printing, along with controlled surface oxidation reaction, to yield a variety of patterns with various grey scale levels. We will also present our recent findings on hybrid (organic/inorganic) nanothick solar cells and possible ways to improve their performance
Model development of hydroxyproline induced hyperoxaluria in young growing pigs (2017)

Aim of the study. In this study, we sought to create a model of reversible hyperoxaluria in pigs by feeding with hydroxyproline (HP). Materials and methods. The experiment included 12 pigs divided into 2 groups (n = 6). The pigs were fed twice a day. At the beginning of the experiment, in the adaptation period, all pigs were given standard feed. In the next 7 days, an increasing amount of hydroxyproline (1–3% HP), was added to the feed. In next 14 days, 4% HP was administered in each pig meal. After 14 days of 4% HP diet, the pigs were randomly divided into 2 groups. For 6 pigs, 4% HP treatment had been continued for the next 14 days while the second group of pigs for the next 14 days received a standard HP free diet. 24h urine samples, blood and fecal samples were collected on particular days. Results. The addition of HP to the diet increased urinary oxalate excretion. A characteristic increase was noted after 12 days of treatment with 4% HP. During the removal period, oxalate excretion decreased in the group without HP in diet, while in the group which continued with a 4% HP diet, oxalate excretion significantly increased. Gross examination of kidneys showed that in the group which had 4% HP diet for 4 weeks, kidneys were fibrotic with enlarged cavities, and had small visible urinary stones. In second group, kidneys were relatively normal looking with no visible stones. Conclusion. Hyperoxaluria is reversible, if HP is removed 14 days after the start of 4% HP diet. Prolonged exposure up to 4 weeks causes pathologic changes in kidneys including crystals, sand and small stone formation.
Macrotorials: Concept and synthetic examples using PTH (1-34) (2005)

Macrotorials are synthetic peptides that contain a macrocyclic core and two or more appendages. By consolidating a relatively rigid component with diversity in the side arms, the advantages of combinatorial chemistry may be used to probe a given volume of conformational space. As an initial foray into this new class of molecules, several analogs of parathyroid hormone (PTH 1-34) were synthesized by solid phase methods using orthogonal (Boc and Fmoc) protection. These individual molecules were characterized by amino acid analysis, positive and negative modes of electrospray mass spectrometry, and by PTH binding and functional assay (in progress). Specific sequences are given in Table 1.