gebhart/patrepeval huggingface dataset:
A Specific Strain of Lactic Acid Bacteria, <i>Lactobacillus paracasei</i>, Inhibits Inflammasome Activation In Vitro and Prevents Inflammation-Related Disorders (2020)

Abstract Some strains of lactic acid bacteria (LAB) have anti-inflammatory effects, but the mechanism underlying the alleviation of inflammation by LAB is not fully understood. In this study, we examined the inhibitory effect of a certain strain of LAB, Lactobacillus paracasei, on inflammasome activation, which is associated with various inflammatory disorders. Using bone marrow–derived macrophages from BALB/c mice, we found that L. paracasei, but not L. rhamnosus, suppressed NLRP3 inflammasome activation and inhibited subsequent caspase-1 activation and IL-1β secretion. L. paracasei also had inhibitory effects on AIM2 and NLRC4 inflammasome activation as well as the NLRP3 inflammasome. These inhibitory effects of L. paracasei on inflammasome activation were dependent on autocrine IL-10 induced by L. paracasei–stimulated macrophages. Furthermore, IL-10 production by L. paracasei–stimulated macrophages was involved with phagocytosis and the NOD2 signaling pathway in macrophages. In addition to in vitro studies, oral administration of L. paracasei in C57BL/6 mice reduced monosodium urate crystal–induced peritoneal inflammation in vivo. Moreover, continuous intake of L. paracasei in C57BL/6 mice alleviated high fat diet–induced insulin resistance and aging-induced expression of biomarkers for T cell senescence. Taken together, we demonstrated that L. paracasei inhibits inflammasome activation in vitro and exhibits an anti-inflammatory function in vivo. These results indicate that LAB that have inhibitory effects on inflammasome activation might contribute to the alleviation of inflammation-related disorders.
Standardized Reflection Transformation Imaging (RTI) for Documentation and Research (2019)

Reflection Transformation Imaging (RTI) is a powerful tool to capture the surface of an object for later examination [1]. We brought RTI to the next level regarding reproducibility, simplicity and image quality [2]. Besides the possibility to capture the surface topography, we can measure and reproduce materials composed of complex reflectance behaviours, with high colour and gloss fidelity. Full-featured cross-platform software for the creation and viewing of such enhanced RTIs has been developed and commercialized. The application allows simple interaction and comparison of RTI datasets. However, the crucial feature of RTIs is their interactivity and the possibility to individualize viewing configurations for specific surface examinations. In the context of image interoperability, it is essential to be able to describe such viewing configurations to ensure reproducibility, e.g.in case of collaborative work. The trend of linked open data shows that RTIs as well must follow open access rules. The success of standardized access to image data is demonstrated well by the international image interoperability framework (IIIF). In this paper, we address two issues: The importance of standardized web-access to RTI data as well as an approach to store and disseminate specific RTI viewing configurations.
Cutaneous squamous cell carcinoma metastatic to chronic lymphocytic leukaemia: diagnostic potential of fine needle aspiration cytology (2006)

FNAC supported by ancillary immunocytological techniques could also be used in diagnosis of specific clinical situations such as cancer-to-cancer metastasis of the tandem of SCC-CLL/SLL.
Validation Study of the Multi-Fidelity Toolkit. (2021)

Abstract not provided.
Venetoclax combines synergistically with FLT3 inhibition to effectively target leukemic cells in FLT3-ITD+ acute myeloid leukemia models (2020)

FLT3 internal tandem duplication (FLT3-ITD) mutations account for ~25% of adult acute myeloid leukemia cases and are associated with poor prognosis. Venetoclax, a selective BCL-2 inhibitor, has limited monotherapy activity in relapsed/refractory acute myeloid leukemia with no responses observed in a small subset of FLT3-ITD+ patients. Further, FLT3-ITD mutations emerged at relapse following venetoclax monotherapy and combination therapy suggesting a potential mechanism of resistance. Therefore, we investigated the convergence of FLT3-ITD signaling on the BCL-2 family proteins and determined combination activity of venetoclax and FLT3-ITD inhibition in preclinical models. In vivo, venetoclax combined with quizartinib, a potent FLT3 inhibitor, showed greater anti-tumor efficacy and prolonged survival compared to monotherapies. In a patient-derived FLT3-ITD+ xenograft model, cotreatment with venetoclax and quizartinib at clinically relevant doses had greater anti-tumor activity in the tumor microenvironment compared to quizartinib or venetoclax alone. Use of selective BCL-2 family inhibitors further identified a role for BCL-2, BCL-XL and MCL-1 in mediating survival in FLT3-ITD+ cells in vivo and highlighted the need to target all three proteins for greatest anti-tumor activity. Assessment of these combinations in vitro revealed synergistic combination activity for quizartinib and venetoclax but not for quizartinib combined with BCL-XL or MCL-1 inhibition. FLT3-ITD inhibition was shown to indirectly target both BCL-XL and MCL-1 through modulation of protein expression, thereby priming cells toward BCL-2 dependence for survival. These data demonstrate that FLT3-ITD inhibition combined with venetoclax has impressive anti-tumor activity in FLT3-ITD+ acute myeloid leukemia preclinical models and provides strong mechanistic rational for clinical studies.
Cobalt-Modified Covalent Organic Framework as a Robust Water Oxidation Electrocatalyst (2016)

The development of stable, efficient oxygen evolution reaction (OER) catalyst capable of oxidizing water is one of the premier challenges in the conversion of solar energy to electrical energy, because of its poor kinetics. Herein, a bipyridine-containing covalent organic framework (TpBpy) is utilized as an OER catalyst by way of engineering active Co(II) ions into its porous framework. The as-obtained Co-TpBpy retains a highly accessible surface area (450 m2/g) with exceptional stability, even after 1000 cycles and 24 h of OER activity in phosphate buffer under neutral pH conditions with an overpotential of 400 mV at a current density of 1 mA/cm2. The unusual catalytic stability of Co-TpBpy arises from the synergetic effect of the inherent porosity and presence of coordinating units in the COF skeleton.
Obtaining a Model and Control for a Rigid Body Motion System. Obtaining Inertia Parameters of a Rigid Body and Electromagnetic Characteristics for a Magnetic Levitation System. (1999)

This paper proposes a control method of a rigid body motion system which includes unknown nonlinearity by using motion learning.Defining the motion learning as achievement of objective motion control by obtaining the model of motion system, the proposed control structure consists of feedback controllers to stabilize the unstable motion system, a motion learning system to obtain nonlinear model and to linearize the motion system by using the obtained nonlinear model, and an inverse motion system to generate inputs to be applied to the linearized motion system.The obtained model is described as series of weighted basis functions, and the explicit learning rules of weights are derived by using Popov's hyperstable theory.The tuning rules of feedback gains are determined by using the obtained nonlinear models.Futher, this paper shows the high performance of the proposed method by demonstrating an experiment of the tracking desired trajectory in the electromagnetic levitation and positioning system.
Mixed halide perovskites for spectrally stable and high-efficiency blue light-emitting diodes (2021)

Bright and efficient blue emission is key to further development of metal halide perovskite light-emitting diodes. Although modifying bromide/chloride composition is straightforward to achieve blue emission, practical implementation of this strategy has been challenging due to poor colour stability and severe photoluminescence quenching. Both detrimental effects become increasingly prominent in perovskites with the high chloride content needed to produce blue emission. Here, we solve these critical challenges in mixed halide perovskites and demonstrate spectrally stable blue perovskite light-emitting diodes over a wide range of emission wavelengths from 490 to 451 nanometres. The emission colour is directly tuned by modifying the halide composition. Particularly, our blue and deep-blue light-emitting diodes based on three-dimensional perovskites show high EQE values of 11.0% and 5.5% with emission peaks at 477 and 467 nm, respectively. These achievements are enabled by a vapour-assisted crystallization technique, which largely mitigates local compositional heterogeneity and ion migration.
Modelling and signal processing for the nonlinear thin film recording channel (1992)

Our goal is to determine whether disk storage capacity can be increased by reducing the transition spacing to the point where a significant amount of nonlinearity occurs. This is investigated by allowing a sequence detector with unlimited complexity and assuming an ideal read channel as discussed below. We will make the assumption that the detection is done in the presence of additive white Gaussian noise, so that the Euclidean distance between sequences is the appropriate metric. The complexity of the sequence detector will be assumed sufficient to determine the data sequence that would result in a noise free waveform closest in distance to the observed (noisy) write channel output.
Metal-Citrate Complex Transport in Streptomyces coelicolor (2010)

As more bacterial genomes are sequenced, there is an increase of interest developing as to which genes are responsible for micronutrients acquisition. Many of these genes encode for complex membrane transport systems that facilitate translocation of critical micronutrients across the cellular membrane. The most critical of which are membrane transport proteins that translocate iron. Inspired by the recent genomic sequencing of Streptomyces coelicolor , we set out to explore the secondary metal-citrate transporter Cit Sc . We first functionally characterized what metal-citrate complexes were transported by the native bacterium S. coelicolor , which indicated that Fe 3+ -citrate and Ca 2+ -citrate were readily transported, but Mg 2+ -citrate was not. Then, we identified the gene encoding the metal-citrate transporter through gain of function studies in Escherichia coli . With the successful identification of the gene encoding the metal-citrate transporter, we decided to try to overexpress and purify the secondary metal-citrate transporter. Several expression systems were successfully constructed for overexpression and purification. The most successful construct involved the pFLAG-Cit Sc fusion, which tethered a FLAG·Tag at the C-terminus. Cit Sc _FLAG was semi-purified using antiFLAG antibodies, and Cit Sc _FLAG was identified using Western blot analysis.
Genomic Analysis of Aeromonas veronii C198, a Novel Mcr-3.41-Harboring Isolate from a Patient with Septicemia in Thailand (2020)

The resistance of Gram-negative bacteria to colistin, mediated by plasmid-borne <i>mcr</i> genes, is an emerging public health concern. The complete genome sequence (4.55 Mb) of a clinical isolate of <i>Aeromonas veronii</i> biovar <i>veronii</i> obtained from a patient with septicemia was determined using short-read and long-read platforms. This isolate (C198) was found to harbor a novel <i>mcr-3</i> gene, designated <i>mcr-3.41</i>. Isolate C198 revealed adjacent <i>mcr-3.41</i> and <i>mcr-3</i>-like genes. It contained one chromosome and two plasmids, both of which encoded a RepB replication protein. Other antimicrobial resistance genes, including <i>bla<sub>cphA3</sub>, bla<sub>OXA-12</sub>, tetA, rsmA,</i> and adeF, were also present. Isolate C198 was resistant to amoxicillin-clavulanate, ampicillin-sulbactam and tetracycline, and showed intermediate resistance to trimethoprim-sulfamethoxazole. The isolate was susceptible to piperacillin-tazobactam, carbapenem, third-generation cephalosporins, fluoroquinolones, chloramphenicol, and aminoglycosides. Putative virulence genes in the C198 genome encoded type II, III, and VI secretion systems; type IV <i>Aeromonas</i> pili; and type I fimbria, flagella, hemagglutinin, aerolysin, and hemolysins. Multilocus sequence typing revealed a novel sequence type (ST), ST720 for C198. Phylogenetic analysis of the single nucleotide polymorphisms in C198 demonstrated that the strain was closely related to <i>A. veronii</i> 17ISAe. The present study provides insights into the genomic characteristics of human <i>A. veronii</i> isolates.
Interfacial Dipole Measurement of Dielectric/Silicon Interface by X-ray Photoelectron Spectroscopy (2009)

Interfacial dipole presented at the interface of dielectric/silicon has been measured with x-ray photoelectron spectroscopy. With a use of high energy x-ray source, the band bending profile of a silicon substrate and the surface potential can be determined. By comparing the potential profile for p+ and n+-Si wafer, a voltage shift can be calculated. Using this method, a large negative potential shift of 0.5 V at La-silicate/silicon interface has been observed. The obtained value of interfacial dipole is consistent with the value obtained from gate leakage current analysis.
Estimation of directions of arrival of multipath signals in CDMA systems (2000)

An algorithm is proposed for estimating the directions of arrival (DOAs) of multipath signals received from multiple users on the uplink of a code-division multiple-access system. The correlation matrices of the received signal before and after code-matched filtering are used to provide unique estimates even when the number of required DOAs exceeds the number of antenna array elements. This scenario is well known to cause conventional direction-finding algorithms (such as MUSIC) to fail. Both intersymbol interference (ISI) and multiple-access interference (MAI) are modeled exactly, and so the algorithm performs much better than those which model ISI and MAI as Gaussian noise.
1,5-Ethano-2,3,4,5-tetrahydro-1H-3-benzazepines (1975)

1,5-Ethano-2,3,4,5-tetrahydro-1H-3-benzazepine, from the LiA1H4 reduction of 2-benzyloxy-1,5-ethano-4-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine, was converted to N-alkyl, aralkyl, cycloalkyl, and alkenyl derivatives which were inactive as morphine type analgetics in mice. The LiA1H4 reduction of 2-benzyloxy-1,5-etheno-4-oxo-2,3,4,5-tetrahydro-1H-3-benzazepine gave unstable products from which only the skeletally rearranged dihydro- and tetrahydrobenzo[e]isoindolines, were isolated.
Thin‐layer chromatography combined with diode laser desorption/atmospheric pressure chemical ionization mass spectrometry (2004)

The desorption of an analyte by a continuous wave diode laser from a porous surface of a thin-layer plate covered with a graphite suspension is presented. The thermally desorbed analyte molecules are ionized in the gas phase by a corona discharge at atmospheric pressure. Therefore, both essential processes--the desorption and the ionization of analyte molecules, which are often performed in one step--are separated. The target preparation is easy and fast since no additional extraction process is required. The mass spectrometric background signal was mostly limited to the low mass range showing no interference with typical compounds of interest. In this study, the calmative and antihypertensive drug reserpine was chosen as model analyte, which is often used for specification of mass spectrometers. No fragmentation was observed because of efficient collisional cooling under atmospheric pressure. The influence of diode laser power and the composition of the graphite suspension were investigated, and a primary optimization was performed.
Cost- and Time-Saving Immunohistochemical Method for Co-localization of Prolactin with Growth Hormone or Adrenocorticotropic Hormone in Rat Pituitary (1997)

A cost-effective and time-saving immunohistochernical capillary gap method for consistent single staining of cells in pituitaries from large numbers of rats was developed for localization of prolactin (PRL), growth hormone (GH) or adrenocorticotropic hormone (ACTH). Co-localization of PRL with either GH or ACTH using rabbit polyclonal antibodies required a 5 min enzymatic digestion in 0.04% pepsin/0.1 N hydrochloric acid between antibody stains to reduce background, and an appropriate chromogen selection and application order. In the co-localization experiments, when PRL staining using AEC as chromogen was followed by GH staining using Vector SG as chromogen, a significant number of double-labeled acidophils were seen. If either antibody detection order or chromogen order was reversed, identification of double-labeled cells was more difficult. PRL and ACTH were easily distinguished in the same section of rat pituitary because both hormones were not seen within the same cell. This chromogen combination may have application with other antibodies. (The J Histotechnol 20:313, 1997)
Energy-Per-Bit Performance Analysis of Relay-Assisted Power Line Communication Systems (2018)

This paper provides a comprehensive analysis of the energy efficiency performance for different relaying schemes over the non-Gaussian power line communication (PLC) channel. Specifically, amplify-and-forward (AF), decode-and-forward (DF), selective DF (SDF) and incremental DF (IDF) relaying systems are investigated. For a more realistic scenario, the power consumption profile of the PLC modems is assumed to consist of both dynamic and static power. For each system, we derive accurate analytical expressions for the outage probability and the minimum energy-per-bit performance. For the sake of comparison and completeness as well as to quantify the achievable gains, we also analyze the performance of a single-hop PLC system. Monte Carlo simulations are provided throughout this paper to validate the theoretical analysis. Results reveal that AF relaying over the non-Gaussian PLC channel does not always enhance the performance and that the IDF PLC system offers the best performance compared to all other schemes considered. It is also shown that increasing the channel variance, which is related to the PLC network branching, and impulsive noise probability can considerably deteriorate the system performance. Furthermore, when the end-to-end distance is relatively small, it is found that the single-hop PLC approach can perform better than AF relaying.
Physiological and genetical aspects of the broad based potato population (Solanum tuberosum L.) in the Netherlands and Northern Finland (2006)

Sisältö: CD-ROM sisältää artikkelit Maatalouspäivien 2006 esitelmistä ja postereista kokonaisuudessaan.
Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non–Germinal Center B-Cell Diffuse Large B-Cell Lymphoma (2019)

The study did not meet its primary end point in the ITT or ABC population. However, in patients age younger than 60 years, ibrutinib plus R-CHOP improved EFS, PFS, and OS with manageable safety. In patients age 60 years or older, ibrutinib plus R-CHOP was associated with increased toxicity, leading to compromised R-CHOP administration and worse outcomes. Further investigation is warranted.
[Chlamydia trachomatis in induced abortion]. (1987)

The prevalence of chlamydia trachomatis in the outer cervix was studied and related with the presence of postoperative symptoms and complications, especially regarding salpingitis. The study sample was made up of 379 women who had undergone induced abortions during their 1st trimester at a regional hospital. These women were tested the day prior to surgery for chlamydia trachomatis. A 2nd test was taken immediately after surgery, and a 3d 10 days following that. Of the total 379 patients, 30 (7.9%) had positive test results at the 1st examination. Younger (19 years and under) women had many more positives than did older (p 0.10). At the end of the 1st postoperative month, 5.0% were readmitted because of complications. More chlamydia-positive than chlamydia-negative women were admitted than before the abortions (p 0.09). Postabortem salpingitis was diagnosed among 3:30 (10 percent) of chlamydia-positive women, and 8:346 (2.5%) chlamydia-negative women (p 0.09). Of the 30 chlamydia-positive women, 4 were readmitted to the hospital for inpatient treatment. Of the remaining 26, 4 had such long travelling distances to the hospital that they were only given prescriptions for lymecycline 300 mg x 2 for 7 days, including treatment for their partners. The remaining 22 women were treated as outpatients and given the same dosage of lymecycline as above. 19 of these 22 women were given follow-up examinations around 10 days after treatment ended. All then had negative tests. In light of the high rate of salpingitis found in chlamydia-positive women, the authors urge greater cooperation be established between physicians who examine women in connection with abortions and the hospitals which perform them, with a goal of treating chlamydia-positive women before their abortions, so that post-abortem salpingitis can be prevented.
Global faceting behavior of strained Ge islands on Si (2009)

The evolution of crystallographic facets of strained heteroepitaxial Ge islands on Si is investigated. Islands growing on Si(001), (111), (110) and (113) are bound by an equilibrium set of facets that includes only shared stable surfaces between bulk Si and Ge--{105}, {113}, {15 3 23} and {111}. The formation of a stereographic map from these indices facilitates the prediction of Ge faceted-island shapes on any Si substrate at different stages of growth. The analysis presented here can be applied to other heteroepitaxial islanding systems where a finite set of shared equilibrium facets exists for the bulk starting materials.
SSD – indication and results of cochlear implantation in children (2016)

rate among any size of the perforation or any frequency of otorrhea. There was no serious complication such as sensorineural hearing loss.
Treatment of Relapsed or Refractory AML with Intermediate-dose Arabinosylcytosine (Ara-C): Confirmation of the Importance of Ara-C Triphosphate Formation in Mediating Response to Ara-C (1993)

(1993). Treatment of Relapsed or Refractory AML with Intermediate-dose Arabinosylcytosine (Ara-C): Confirmation of the Importance of Ara-C Triphosphate Formation in Mediating Response to Ara-C. Leukemia & Lymphoma: Vol. 10, No. sup1, pp. 115-121.