gebhart/patrepeval huggingface dataset:
Development of a Large-Scale Iodine-125 Production System at UC Davis/MNRC - eScholarship (2008)

The demand for iodine-125 (125I) as a medical radioisotope for use in the treatment of prostate cancer continues to increase. However, due to uncertainties with current commercial production facilities, potential supply issues have emerged prompting several reactors worldwide to consider the development and installation of large-scale 125I production facilities. In 2002, MNRC installed and operated successfully for ~ 1.5 years, a closed loop system using aluminum material for containment of the enriched 124Xe (99%) target during irradiation. However, problems with design features and restrictions on serviceability and repairs ultimately forced MNRC to abandon it as a first target failure resulted in high contamination levels in the whole system which further restricted personnel accessibility. Today, a new target and a multi-compartment (modular) transport and decay system with automatic operation and dispensing of high-level batches of 125I and with ready access for maintenance and repairs have been designed to resume 125I production activities. The new operating conditions provide ample opportunities for increased production with shorter irradiation times.
Abstract 3679: Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma (2014)

Abstract Ewing sarcoma is an aggressive pediatric bone tumor characterized by an absolute reliance on the transcriptional activity of the EWS/ETS family of transcription factor fusion oncoproteins. The most common fusion is EWS/FLI, present in 85-95% of cases, though less common fusions include EWS/ERG, EWS/ETV1, EWS/ETV4 and EWS/FEV. EWS/FLI utilizes lysine-specific demethylase 1 (LSD1) as member of the NuRD complex to mediate transcriptional repression of critical tumor suppressors in Ewing sarcoma. LSD1 overexpression has been observed in clinical samples from Ewing sarcoma patients and small molecule blockade of LSD1 using tranylcypromine has been suggested as a therapeutic approach for Ewing sarcoma. We therefore evaluated the effects of LSD1 inhibition with the small molecule inhibitor, HCI-2509, in both in vitro and in vivo models of Ewing sarcoma. HCI-2509 is an LSD1 inhibitor with a Ki of ∼30 nM and multiple Ewing sarcoma cell lines show IC50s in cell viability assays from 500 nM-1 μM. Using RNA-seq, we show that HCI-2509 dramatically reverses both the up- and downregulated transcriptional profiles of both EWS/FLI and EWS/ERG accompanied by the induction of apoptosis and disruption of oncogenic phenotypes modulated by EWS/FLI. We further developed a 9-gene panel based on the RNA-seq data to assess the transcriptional phenotype of HCI-2509 in additional cell lines and showed that it HCI-2509 disrupted both EWS/FLI-activated and -repressed genes similarly across the tested Ewing sarcoma cell lines. HCI-2509 impaired transformation of Ewing sarcoma cell lines in colony forming assays with IC50s from from 25 nM-1 μM. Notably, HCI-2509 displayed single-agent efficacy in multiple xenograft models. We investigated the PK/PD relationship using tumor histone H3K4 and H3K9 methylation. Taken together, these data suggest that epigenetic modulation through LSD1 inhibition may be a therapeutic strategy for Ewing sarcoma, and highlight a critical dual role for LSD1 in the oncogenic transcriptional activity of EWS/ETS proteins. Citation Format: Emily Rose Theisen, Savita Sankar, Jared Bearss, Timothy Mulvihill, Venkataswamy Sorna, Sunil Sharma, Stephen L. Lessnick. Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 3679. doi:10.1158/1538-7445.AM2014-3679
Supplementary Figures from Silencing Fc Domains in T cell–Engaging Bispecific Antibodies Improves T-cell Trafficking and Antitumor Potency (2023)

&lt;p&gt;Supplementary Figures&lt;/p&gt;
High‐Throughput Screening of Blade‐Coated Polymer:Polymer Solar Cells: Solvent Determines Achievable Performance (2021)

Optimization of a new system for organic solar cells is a multiparametric analysis problem that requires substantial efforts in terms of time and resources. The strong microstructure-dependent performance of polymer:polymer cells makes them particularly difficult to optimize, or to translate previous knowledge from spin coating into more scalable techniques. In this work, the photovoltaic performance of blade-coated devices was studied based on the promising polymer:polymer system PBDB-T and PF5-Y5 as donor and acceptor, respectively. Using the recently developed high-throughput methodology, the system was optimized for multiple variables, including solvent system, active layer composition, ratio, and thickness, among others, by fabricating more than 500 devices with less than 24 mg of each component. As a result, the power conversion efficiency of the blade-coated devices varied from 0.08 to 6.43 % in the best device. The performed statistical analysis of the large experimental data obtained showed that solvent selection had the major impact on the final device performance due to its influence on the active layer microstructure. As a conclusion, the use of the plot of the device efficiency in the Hansen space was proposed as a powerful tool to guide solvent selection in organic photovoltaics.
High Dynamic Range Imaging with TDC-Based CMOS SPAD Arrays (2019)

This paper investigates the use of image sensors based on complementary metal–oxide–semiconductor (CMOS) single-photon avalanche diodes (SPADs) in high dynamic range (HDR) imaging by combining photon counts and timestamps. The proposed method is validated experimentally with an SPAD detector based on a per-pixel time-to-digital converter (TDC) architecture. The detector, featuring 32 × 32 pixels with 44.64-µm pitch, 19.48% fill factor, and time-resolving capability of ~295-ps, was fabricated in a 150-nm CMOS standard technology. At high photon flux densities, the pixel output is saturated when operating in photon-counting mode, thus limiting the DR of this imager. This limitation can be overcome by exploiting the distribution of photon arrival times in each pixel, which shows an exponential behavior with a decay rate dependent on the photon flux level. By fitting the histogram curve with the exponential decay function, the extracted time constant is used to estimate the photon count. This approach achieves 138.7-dB dynamic range within 30-ms of integration time, and can be further extended by using a timestamping mechanism with a higher resolution.
Design of a Wideband Variable-Gain Amplifier With Self-Compensated Transistor for Accurate dB-Linear Characteristic in 65 nm CMOS Technology (2020)

A simple yet effective approach for variable-gain amplifier (VGA) design with accurate dB-linear characteristic is presented. In order to extend the bandwidth of the designed VGA with a minimized footprint, an inductorless-based approach is adopted. Moreover, a unique approach that exploits a self-compensated transistor to compensate dB-linear gain error is proposed. Consequently, the overall VGA has an accurate dB-linear inherent characteristic without using any additional exponential generator for gain control. To prove the concept, the designed VGA is fabricated in a standard 65 nm CMOS technology. The measured results show that the voltage gain of the designed VGA can be controlled from -19 dB to 21 dB with a gain error less than 1 dB. Meanwhile, more than 4 GHz of bandwidth can be achieved for the entire gain range. The power consumption of the VGA, excluding the output buffer, is 3.9 mW. The core circuit of this design only occupies an area of 0.012 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> .
Recursive Sketches for Modular Deep Learning (2019)

We present a mechanism to compute a sketch (succinct summary) of how a complex modular deep network processes its inputs. The sketch summarizes essential information about the inputs and outputs of the network and can be used to quickly identify key components and summary statistics of the inputs. Furthermore, the sketch is recursive and can be unrolled to identify sub-components of these components and so forth, capturing a potentially complicated DAG structure. These sketches erase gracefully; even if we erase a fraction of the sketch at random, the remainder still retains the `high-weight' information present in the original sketch. The sketches can also be organized in a repository to implicitly form a `knowledge graph'; it is possible to quickly retrieve sketches in the repository that are related to a sketch of interest; arranged in this fashion, the sketches can also be used to learn emerging concepts by looking for new clusters in sketch space. Finally, in the scenario where we want to learn a ground truth deep network, we show that augmenting input/output pairs with these sketches can theoretically make it easier to do so.
One‐Step Synthesis of Alkaline‐Soluble Polystyrene Containing Trimethoxysilyl‐ and Boronic Acid‐Moieties as Inorganic, Reactive Pendant Groups for Photosensitive Materials (2021)

Abstract It is of great interest in simple preparation of organic–inorganic hybrid thermoset soluble in alkaline developer, intended for photosensitive materials used in the field of semiconductor packaging based on sophisticated molecular design from the viewpoint of performance improvement and cost reduction. Here successful one‐step synthesis of alkaline‐soluble polystyrene with three kinds of pendant groups along the chain; trimethoxysilyl (TMS), boronic acid (BA), and hexafluoroisopropylalcohol (HFA) groups is shown. Solvent composition‐based equilibrium control of reactions involving the inorganic pendant groups (TMS and BA) as well as the hydrogen bonding ability and sterically bulky structure of the HFA group are effective in suppressing cross‐linking reactions during polymerization. The latter is confirmed through DFT calculation and terpolymerization experiments where the effect of the HFA group is compared to other ten kinds of p‐substituted functional groups. The obtained terpolymer is soluble in alkaline developer and forms an insoluble membrane with high heat‐resistance after heat treatment. Furthermore, its photosensitive polymer composition with photochemical acid generator exhibits negative‐type photosensitivity. The organic–inorganic hybrid thermosetting polystyrene is a promising material for semiconductor package applications.
Dynamic resource management in internet hosting platforms (2005)

Internet applications such as on-line news, retail, and financial sites have become commonplace in recent years. Due to the prevalence of these applications, platforms that host them have become an important and attractive business. These platforms, called hosting platforms, typically employ large clusters of servers to host multiple applications. Hosting platforms provide performance guarantees to the hosted applications, such as guarantees on response time or throughput, in return for revenue. Two key features of Internet applications make the design of hosting platforms challenging. First, modern Internet applications are extremely complex. Existing resource management solutions rely on simple abstractions of these applications and are therefore fail to accurately capture this complexity. Second, these applications exhibit highly dynamic workloads with multi-time-scale variations. Managing the resources in a hosting platform to realize the often opposing goals of meeting application performance targets and achieving high resource utilization is therefore a difficult endeavor. In this thesis, we present resource management mechanisms that an Internet hosting platform can employ to address these challenges. Our solution consists of resource management mechanisms operating at multiple time-scales. We develop a predictive dynamic capacity provisioning technique for Internet applications that operates at the time-scale of hours or days. A key ingredient of this technique is a model of an Internet application that is used for deriving the resource requirements of the application. We employ both queuing theory and empirical measurements to devise models of Internet applications. The second mechanism is a reactive provisioning technique that operates at the time-scale of a few minutes and utilizes virtual machine monitors for agile switching of servers in the hosting platform among applications. Finally, we develop a policing technique that operates at a per-request level. This technique allows a hosted application to remain operational even under extreme overloads where the arrival rates are an order of magnitude higher than the provisioned capacity. Our experiments on a prototype hosting platform consisting of forty Linux machines demonstrate the utility and feasibility of our techniques.
Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors (2015)

Dengue virus is an increasingly global pathogen. One of the promising targets for antiviral drug discovery against dengue and related flaviviruses such as West Nile virus is the viral serine protease NS2B-NS3. We here report the synthesis and in vitro characterization of potent peptidic inhibitors of dengue virus protease that incorporate phenylalanine and phenylglycine derivatives as arginine-mimicking groups with modulated basicity. The most promising compounds were (4-amidino)-L-phenylalanine-containing inhibitors, which reached nanomolar affinities against dengue virus protease. The type and position of the substituents on the phenylglycine and phenylalanine side chains has a significant effect on the inhibitory activity against dengue virus protease and selectivity against other proteases. In addition, the non-natural, basic amino acids described here may have relevance for the development of other peptidic and peptidomimetic drugs such as inhibitors of the blood clotting cascade.
Simulation of an hybrid blood cells micro-separator (2015)

The paper presents numerical analysis in three-dimensional (3D) of a hybrid micro-separator that uses magnetophoresis (MAP) and hydrodynamic forces for blood cells separation. The separation between red blood cells (RBC) and white blood cells (WBC) is done by manipulating the differences of their physical and magnetic susceptibilities. The MAP force is induced from ferromagnetic line fabricated on a glass slide while the hydrodynamic force is obtained by a `U' shape microfluidic channel. The analysis was conducted using finite element software, COMSOL Multiphysics®. The particles trajectories, which represent the actual blood cells' movements on the micro-separator, were profiled and show successful separation between RBCs and WBCs by using the MAP and hydrodynamic forces. This study also provides insights of challenges associated with blood separation towards the realization of better diagnostic devices.
Supplementary Figure S7 from Induction of T-cell Immunity Overcomes Complete Resistance to PD-1 and CTLA-4 Blockade and Improves Survival in Pancreatic Carcinoma (2023)

&lt;p&gt;Supplementary Figure S7. Tumor growth curves of individual mice with subcutaneous PDA treated as indicated.&lt;/p&gt;
Investigation of the Internal Chemical Composition of Chitosan-Based LbL Films by Depth-Profiling X-ray Photoelectron Spectroscopy (XPS) Analysis (2018)

Chitosan-based thin films were assembled using the layer-by-layer technique, and the axial composition was accessed using X-ray photoelectron spectroscopy with depth profiling. Chitosan (CHI) samples possessing different degrees of acetylation ([Formula: see text]) and molecular weight ([Formula: see text]) produced via the ultrasound-assisted deacetylation reaction were used in this study along with two different polyanions, namely, sodium polystyrenesulfonate (PSS) and carboxymethylcellulose (CMC). When chitosan, a positively charged polymer in aqueous acid medium, was combined with a strong polyanion (PSS), the total positive charge of chitosan, directly related to its [Formula: see text], was the key factor affecting the film formation. However, for CMC/CHI films, the pH of the medium and [Formula: see text] of chitosan strongly affected the film structure and composition. Consequently, the structure and the axial composition of chitosan-based films can be finely adjusted by choosing the polyanion and defining the chitosan to be used according to its DA and [Formula: see text] for the desired application, as demonstrated by the antibacterial tests.
FPGA-based Dynamic Duty Cycle and Frequency Controller for a Class-E<sup>2</sup> DC-DC Converter (2018)

This paper presents a controller that achieves zero-voltage and zero-dv/dt switching (ZVS and ZVDS) for a class-E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> dc-dc converter under a wide variation in the input and output voltages. One of the major problems in using the class-E topology for dc-dc conversion is that the increased switching loss significantly degrades the efficiency when the voltage condition deviates from the point which the circuit is designed for. The proposed controller modulates the duty cycle and the frequency of the gate driving signal so that ZVS and ZVDS are always achieved under the voltage variation, while regulating the output voltage by on-off control. We demonstrate an FPGA-based prototype controller in conjunction with a 2 MHz isolated class-E <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> dc-dc converter that minimizes the efficiency drop due to the switching loss for the input voltage from 80 V to 200 V and the output voltage from 5 V to 20 V.
Improving Policy Functions in High-Dimensional Dynamic Games (2015)

In this paper, we propose a method for finding policy function improvements for a single agent in high-dimensional Markov dynamic optimization problems, focusing in particular on dynamic games. Our approach combines ideas from literatures in Machine Learning and the econometric analysis of games to derive a one-step improvement policy over any given benchmark policy. In order to reduce the dimensionality of the game, our method selects a parsimonious subset of state variables in a datadriven manner using a Machine Learning estimator. This one-step improvement policy can in turn be improved upon until a suitable stopping rule is met as in the classical policy function iteration approach. We illustrate our algorithm in a high-dimensional entry game similar to that studied by Holmes (
ChemInform Abstract: Synthesis and Reaction of 5,6,7,8‐Tetrahydro‐4H‐oxazolo[4,5‐c]azepin‐4‐ones. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Unsymmetrical Diaryl Ketones from Arenes. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
BG1, a candidate gene affecting the occurrence of herpesvirus–associated avian lymphomas (2008)

Oncogenic herpesvirus infections contribute to the occurrence of lymphomas in the human population. Genetic makeup may have a role in susceptibility. Through genetic mapping with recombinant haplotypes we have identified BG1 , a member of the extended butyrophilin gene family, as a gene having a significant role in MHC‐associated resistance to the occurrence of T‐cell lymphomas that often follow infection with gallid herpesvirus 2 in the chicken animal model. Significant differences in tumor incidence occur among congenic birds differing only at the BG1 locus. Two alleles, BG1*R2 and BG1*R4 , are respectively associated with tumor resistance and susceptibility. The alleles differ only in the 3′‐untranslated region (3′‐UTR) with the longer 3′‐UTR of the BG1*R4 allele containing unique sequence. In dual Firefly/Renilla luciferase reporter assays we found that the 3′‐UTR of the BG1*R4 suppresses PMA‐stimulated translation of the firefly reporter gene, while the 3′‐UTR of BG1*R2 has a far less inhibitory influence. With further constructs we have narrowed the effective region of the BG1*R4 3′‐UTR to a region relatively rich in CG dinucleotides. Supported in part by NCI R21 CA105426.
ADAM (a Disintegrin and Metalloproteinase) 15 Deficiency Exacerbates Ang II (Angiotensin II)–Induced Aortic Remodeling Leading to Abdominal Aortic Aneurysm (2020)

This study is the first to demonstrate a key role for ADAM15 in abdominal aortic aneurysm through regulating the SMC function, thereby placing ADAM15 in a critical position as a potential therapeutic target for abdominal aortic aneurysm.
Third-Time Coronary Artery Revascularization (1993)

Eighteen patients underwent a third coronary artery revascularization (rere-CABG) between 1983 and 1991. The factors necessitating rere-CABG were graft failure in 83% of the patients and progression of native coronary atherosclerosis in 17%. Mean interval between the second and third operation was 49.1 months. Median sternotomy and cardiopulmonary bypass (CPB) were used in 12 patients, a left thoracotomy approach was used in 6 (with CPB in 3 patients and without CPB in 3). The mean revascularization rate was 2.2 (grafts/patient). The internal thoracic artery was employed in 12 patients and the right gastroepiploic artery was used in one. Operative mortality was 11.1% (2 deaths). Non-fatal perioperative myocardial infarction, reexploration for bleeding, and respiratory failure occurred in one patient each. There were no other serious complications. Long-term follow-up was obtained in 15 of the 16 survivors. Four patients had recurrence of angina pectoris, and one late death due to myocardial infarction occurred. The myocardial event-free rate was 75% at 3.4 years. This experience indicates that a third coronary revascularization can be justified: operative approach and choice of graft material have to be individualized, but adequate long-term results can be obtained.
PPPS-2013: A robust, low-inductance, low-jitter switch for petawatt-class pulsed power accelerators (2013)

Spark gap switches are integral components in pulsed power applications ranging from pulsed microwaves and flash x-ray sources to, more recently, the linear transformer drivers (LTDs) powering next-generation petawatt-class pulsed power accelerators at Sandia National Laboratories (SNL) in Albuquerque, New Mexico. An LTD system uses a triggered switch to conduct current from two capacitors to form a magnetic field which accelerates particles down magnetically insulated transmission lines (MITLs). Existing spark gap switches suffer from limited lifetimes <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> and levels of jitter and inductance in excess of what will be required for these new accelerators <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . Kinetech, under a contract from SNL, has designed, developed, and demonstrated a switch that exceeds all of the established requirements <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> by firing for 57,200 shots with an inductance of 35 nH and a one-sigma switch jitter of 1.2 ns variation over a 1,000 shot sampling after 1k, 25k, and 50k shots. This paper will detail the design, development, and demonstration of this switch by Kinetech and SNL.