gebhart/patrepeval huggingface dataset:
Herpes zoster after liver transplantation: Incidence, risk factors, and complications (2004)

Herpes zoster is the consequence of the reactivation of latent varicella-zoster infection. Immunosuppression may be a predisposing factor for herpes zoster. We have retrospectively assessed the risk of herpes zoster, the risk factors for its occurrence, and its evolution in a population of 209 consecutive liver transplant recipients. Herpes zoster developed in 25 (12%) of patients. One-, 3-, 5-, and 10-year actuarial rates of herpes zoster were 3%, 10%, 14%, and 18%, respectively. In a case-control study, patients developing herpes zoster were younger, received a higher number of immunosuppressive drugs, and were more frequently receiving mycophenolate mofetil or azathioprine. In multivariate analysis, the only factor related to herpes zoster occurrence was treatment with mycophenolate mofetil or azathioprine. Eight patients (31%) developed postherpetic neuralgia. In conclusion, herpes zoster is a relatively common complication after liver transplantation. It is related to immunosuppressive therapy. Postherpetic neuralgia develops in one third of patients with posttransplant herpes zoster.
Key structural periods and Permian tight gas accumulation response in Hangjinqi area, Ordos Basin (2021)

Critical tectonic period is a critical time point that characterizes the genetic connection and causal relation (accumulation response) between tectonic effect and oil/gas accumulation in large superposition basins, it is also an important "window" for analyzing accumulation evolution and accumulation regularity of oil/gas. Based on the systematic review of the tectonic evolution history of the Ordos Basin, the tectonic evolution and deformation sequence since the Mesozoic in Hangjinqi area in the northern part of Ordos Basin were studied through the constraints of apatite fission tracks and other thermal chronological indicators. Two key structural periods including J3-K1 and K2-E1 were proposed. It was believed by combining with the understanding of the Carboniferous-Permian hydrocarbon-generating and reservoir-forming histories that the J3-K1 was the period of design finalization in the Hangjinqi area which formed a currant NE-trending structural framework "high in the northeast and low in the southwest" during which, lithologic gas reservoirs including the Carboniferous Taiyuan and the Permian Shanxi formations, first member of the Permian Shihezi Formation to the north of the Sanyanjing-Wulan Jilin Temple-Bo'erjiang Haizi fault were formed and corresponding to the period of great amount of hydrocarbon generated and expulsed from source rocks as well as the densification of sandstones. On the other hand, the K2-E1 period was the major stage for fault reactivation and the formation of NE-trending tectonic trap and NW-trending fault that led to the adjustment of early lithologic gas reser-voirs in the south and the formation of structural or structural-lithologic gas reservoirs in the north. The difference of accumulation on each sides of the main fault is obvious. The southern part was formed earlier than the northern part, and was dominated by lithologic gas reservoirs yet the northern part was dominated by structural-lithological gas reservoirs. The southern gas-bearing strata are dominated by deep strata, while those in the north are both shallow and deep ones. In Paleogene, lifting in the north caused loss of gas. The key accumulation and transformation periods transformed with space and time, which transformed accumulation factors differentially and finally constrained the enrichment and depletion of natural gas.
Intestinal bacteria as a key factor for alcoholic steatosis in mice (2004)

info:eu-repo/semantics/nonPublished
Commissioning of the Sardinia Radio Telescope in Italy: Results and perspectives (2014)

On 30 September 2013, the opening ceremony of SRT has signed the contractual ending of the instrumental commissioning of the Sardinia Radio Telescope. In February 2014 it has been completed also the “fine tuning process” aimed at defining the first optimizations parameters needed to make calibrated radio astronomical observations. Since then, the final Astronomical Validation, that was just started in parallel with the previous activities, has taken the lead of the user's allocated time. At the time of the real presentation in August we expect to be able to present the experimental quantitative results of the commissioning that at the time of this writing are still under analysis.
Guaranteed Diversity and Optimality in Cost Function Network Based Computational Protein Design Methods (2021)

Proteins are the main active molecules of life. Although natural proteins play many roles, as enzymes or antibodies for example, there is a need to go beyond the repertoire of natural proteins to produce engineered proteins that precisely meet application requirements, in terms of function, stability, activity or other protein capacities. Computational Protein Design aims at designing new proteins from first principles, using full-atom molecular models. However, the size and complexity of proteins require approximations to make them amenable to energetic optimization queries. These approximations make the design process less reliable, and a provable optimal solution may fail. In practice, expensive libraries of solutions are therefore generated and tested. In this paper, we explore the idea of generating libraries of provably diverse low-energy solutions by extending cost function network algorithms with dedicated automaton-based diversity constraints on a large set of realistic full protein redesign problems. We observe that it is possible to generate provably diverse libraries in reasonable time and that the produced libraries do enhance the Native Sequence Recovery, a traditional measure of design methods reliability.
Toolbox for exploration of energy-efficient event processors for human-computer interaction (2017)

The advent of high speed input sensor and display technologies and the drive for faster interactive response suggests that human-computer interaction (HCI) task processing deadlines of a few milliseconds or less may be required in future handheld devices. At the same time, users will expect the same, if not better, battery life than today's devices under these more stringent response requirements. In this paper, we present a toolbox for exploring the design space of HCI event processors. We first describe the simulation platform for interactive environments that runs mobile user interface code with inputs recorded from human users. We validate it against a hardware platform from prior work. Given system-level constraints on latency, we demonstrate how this toolbox can be used to design a custom heterogeneous event processor that maximizes battery life. We show that our toolbox can pick design points that are 1.5-2.5× more energy-efficient than general-purpose big. LITTLE architectures.
Systematic review of the diagnostic performance of serum markers of liver fibrosis in alcoholic liver disease (2012)

There are limited numbers of small studies evaluating the accuracy of biomarkers in identifying fibrosis on biopsy in ALD. Some showed promise (both HA alone and some panels) in the identification of cirrhosis/severe fibrosis and could be used to rule it out in heavy drinkers. Biomarkers less accurate with less severe fibrosis.
Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2‐Arachidonoylglycerol (2009)

Biosynthesis Inhibition: O-5596, a new inhibitor of the biosynthesis of the endocannabinoid, 2-arachidonoylglycerol, was synthesized and found to be potent (IC(50)=100 nM) and selective versus other proteins and enzymes of the endocannabinoid system in vitro and active in vivo at reducing food intake in mice.
Coordinate regulation of glucose transporter function, number, and gene expression by insulin and sulfonylureas in L6 rat skeletal muscle cells. (1989)

The extrapancreatic actions of sulfonylureas on the glucose transport system were studied in the L6 line of cultured rat skeletal muscle cells. Insulin (10(-7) M) increased 2-deoxyglucose uptake in differentiated L6 myotubes by 30-40% after 8 h of incubation. The sulfonylurea tolazamide (0.6 mg/ml, 22 h) had no effect on glucose uptake in the absence of insulin, but increased insulin-stimulated 2-deoxyglucose uptake twofold. The total cellular content of glucose transporters was assessed with a monoclonal anti-transporter antibody by a solid-phase ELISA method. Insulin (8 h) increased the quantity of glucose transporters, with a maximal twofold increase at 10(-7) M and a dose-response curve similar to that for insulin stimulation of glucose uptake. In spite of its lack of effect on glucose uptake, tolazamide alone (0.6 mg/ml) increased the cellular content of transporters by 70%. The effects of insulin and tolazamide on transporter gene expression were studied with probes derived from Hep G2 glucose transporter cDNA. Insulin increased the transporter mRNA level 1.7-fold, tolazamide increased it 1.5-fold, and the combination of insulin and tolazamide increased transporter mRNA 3-fold. It is concluded that sulfonylureas, together with insulin, enhance glucose uptake in L6 skeletal muscle cells by increasing the number of functioning glucose transport molecules. The long-term regulation of the glucose transport system in skeletal muscle by insulin and sulfonylureas in vivo may involve similar changes in transporter function, number, and gene expression.
Development of a Simple Magnetic Position Sensor and Its Application to Artificial Hearts (1989)

A new pump stroke sensor has been developed for a totally implantable artificial heart system. Pump stroke sensor is essential for control and monitor of the artificial heart. The developed stroke sensor has the following characteristics; linear output to pump stroke, small size fitting into the implantable control unit, and long-term reliability. The pump stroke sensor is comprised of three permanent magnets of specific combination and a Hall effect sensor. The magnets consists of a permanent magnet disk and a pair of rectangular parallelepiped magnets placed on the magnet disk. The magnets are fixed on a pusher-plate of the blood pump. This specific combination of magnets provides the Hall sensor with linear output to pump stroke. The optimum design of the magnets was calculated from magnetic circuit analysis. Simulated result gave extremely good agreement with the experimental results. The new pump stroke measuring method has accuracy of better than 5%. In vitro experimental result of the motordriven artificial heart utilizing this pump stroke sensor showed excellent results.The pump stroke measuring method using the specificaly designed permanent magnets is useful for not only the artificial heart system but also other electro-mechanical systems.
From the Gait Laboratory to the Rehabilitation Clinic: Translation of Motion Analysis and Modeling Data to Interventions That Impact Anterior Cruciate Ligament Loads in Gait and Drop Landing (2013)

In female athletes the risk of anterior cruciate ligament (ACL) injury during impact-related activities such as landing is higher compared to males. Both how and why this occurs has been at the forefront of orthopedic sports medicine research over the past 20 years. Many individuals with an ACL-deficient knee compensate for joint instability in an effort to remain physically active. Yet others do not compensate and are faced with a reduction in their activities and/or meniscus tears and eventually osteoarthritis. In this article we attempt to link 2 distinct but related scientific disciplines (in vivo motion analysis assessment and computational modeling) to show how these techniques have emerged as powerful tools in our understanding of knee function. Normal knee function and the biomechanics of the ACL-deficient (ACLd) and ACL-reconstructed (ACLr) knee are summarized. Basic experiments concerning the mechanism of noncontact ACL injury as well as performance adaptations in ACLd and ACLr knees are reviewed, and the biomechanics of the normal, ACLd, and ACLr knees under more strenuous activities, such as landing from a jump, are provided.
Effect of Intravenous Golimumab on Fatigue and the Relationship with Clinical Response in Adults with Active Ankylosing Spondylitis in the Phase 3 GO-ALIVE Study (2023)

ClinicalTrials.gov identifier, NCT02186873.
Scavenging Alkyl Mercaptans: Elucidation of Reaction Mechanisms and Byproduct Characterization (2020)

The removal of alkyl mercaptans via chemical means in the oil and gas industry has received very little attention compared with the much more extensive work on hydrogen sulfide (H2S) scavenging. The removal of H2S from produced liquids, aqueous, hydrocarbon, and gas is a vitally important part of the oil and gas industry. Typically, liquid chemical scavengers are employed for H2S levels up to approximately 5000 ppm. Above this, sequestering-type methods are employed such as amine recycling units from which the H2S can be regenerated and used most typically to produce elemental sulfur. It has been known for some time that mercaptan scavenging is possible but anecdotally reported as being less effective than H2S scavenging. This current study seeks to improve the understanding of the efficacy and mechanism of mercaptan scavenging by the common H2S scavengers in use today. A thorough literature review is provided of the current state of the art in mercaptan scavenging is provided. For the first time, a systematic series of quantified scavenging performance results for a variety of prominent scavengers with volatile alkyl mercaptans have been presented using the well-known autoclave method. These results are directly compared with the corresponding values for H2S under identical reaction conditions; overall, the best product was 1,3,5-trimethylhexahydrotriazine (MMA-triazine). The chemical structures of the reaction byproducts with alkyl mercaptans, to date only suggested but never confirmed, have been proven by the application of rigorous analytical methods. Results for both MMA-triazine and 1,3,5-tris(2-hydroxyethyl)hexahydro-s-triazine (MEA-triazine) reactions with ethyl, propyl, and butyl mercaptan comprehensively show, via the use of GCMS(-EI) analysis, representatives from each step in the sequential reaction pathway, containing each 1, 2, and 3 nitrogen atoms showing definitive evidence for the proposed reaction pathway.
Photophysics of chromium-related diamond single-photon emitters (2010)

A detailed study of the photophysical properties of several chromium-related color centers produced within chemical vapor deposition diamond is presented. These emitters show narrow luminescence lines in the range of $740\ensuremath{-}770$ nm. Single-photon emission was verified with continuous and pulsed excitation with detected emission rates at saturation in the range of ($2\ensuremath{-}3$) $\ifmmode\times\else\texttimes\fi{}$ ${10}^{6}$ counts/s, while direct lifetime measurements reveal excited state lifetimes for the distinct centers ranging $1\ensuremath{-}14$ ns. In addition, a number of quantum emitters demonstrate two-level behavior with no bunching present in the second-order correlation function. The three-level systems revealed typically photoluminescence lines with width half-maximum of $~4$ nm while the two-level emitters have full width half-maximum of $~10$ nm at room temperature. In addition, the quantum efficiency of the two-level system was measured to be four times higher than that of the three-level system.
A Novel Method for Illumination Normalization for Performance Improvement of Face Recognition System (2013)

As one of the most successful applications of image analysis, face recognition has received significant attention, especially during past few years. Automatic human face recognition has received substantial attention from researchers in biometrics, pattern recognition and computer vision communities. The machine learning and computer graphics communities are also increasingly involved in face recognition. The localization of human faces in digital images is a fundamental step in the process of face recognition. Although the existing automated machine recognition systems have certain level of maturity, but their accomplishments are limited due to real time challenges. For example, face recognition for the images which are acquired in high contrast with different levels of illumination is a critical problem. It is known that image variation due to lighting changes is larger than that, due to different personal identity, because lighting direction alters the relative gray scale distribution of a face image. In handling these types of practical scenarios, the system must be robust enough to deal with dynamic changes in lighting, hence it is equally important to preprocess the images prior to actual processing and experimentations. This paper proposes a novel method of illumination normalization based on histogram of an image and scaling function. It helps in construction of an optimal global lighting space from these images which improve accuracy of face recognition system. The proposed method helps in recognition of sparsely sampled images with different lighting too. Also, most valuable information of an image, i.e. gray scale value, is not discarded and person's discriminative information in face image is strengthened. Hence recognition can be carried out using preserved illumination invariant features.
An effective and accurate identification system of <i>Mycobacterium tuberculosis</i> using convolution neural networks (2019)

Tuberculosis (TB) remains the leading cause of morbidity and mortality from infectious disease in developing countries. The sputum smear microscopy remains the primary diagnostic laboratory test. However, microscopic examination is always time-consuming and tedious. Therefore, an effective computer-aided image identification system is needed to provide timely assistance in diagnosis. The current identification system usually suffers from complex color variations of the images, resulting in plentiful of false object detection. To overcome the dilemma, we propose a two-stage Mycobacterium tuberculosis identification system, consisting of candidate detection and classification using convolution neural networks (CNNs). The refined Faster region-based CNN was used to distinguish candidates of M. tuberculosis and the actual ones were classified by utilizing CNN-based classifier. We first compared three different CNNs, including ensemble CNN, single-member CNN, and deep CNN. The experimental results showed that both ensemble and deep CNNs were on par with similar identification performance when analyzing more than 19,000 images. A much better recall value was achieved by using our proposed system in comparison with conventional pixel-based support vector machine method for M. tuberculosis bacilli detection.
Studying and remedying secondary school students' modelling skills: A case study (2004)

sponsorship: Afdeling Didactiek.
From biological pathways to regulatory networks (2010)

This paper presents a general theoretical framework for generating Boolean networks whose state transitions realize a set of given biological pathways or minor variations thereof. This ill-posed inverse problem, which is of crucial importance across practically all areas of biology, is solved by using Karnaugh maps which are classical tools for digital system design. It is shown that the incorporation of prior knowledge, presented in the form of biological pathways, can bring about a dramatic reduction in the cardinality of the network search space. Constraining the connectivity of the network, the number and relative importance of the attractors, and concordance with observed time-course data are additional factors that can be used to further reduce the cardinality of the search space. The networks produced by the approaches developed here should facilitate the understanding of multivariate biological phenomena and the subsequent design of intervention approaches that are more likely to be successful in practice.
Minimal Invasive Extracorporeal Circulation (MIECC) and the Role of Shed Blood Separation on the Inflammation-Process after CABG Surgery (2017)

Objectives: Cardiopulmonary bypass (CPB) triggers a systemic inflammatory response syndrome (SIRS) largely caused by the contact of blood with foreign surfaces and by recirculation of activated shed mediastinal blood, a main cause of blood cell activation and cytokine release. Minimal invasive Extracorporeal Circulation (MiECC) comprises a completely closed (no blood-air contact) circuit, coated surfaces (biocompatible treatment) and the separation of suction blood. All three aspects have the potential to reduce this activation. This study investigates the impact of washed or unwashed shed blood on initiating of inflammatory processes.
Factors associated with and consequences of unplanned post-operative intubation in elderly vascular and general surgery patients (2010)

Although the incidence of UPI in this elderly surgical cohort was low, it was associated with significant morbidity and mortality as well as prolonged hospital length of stay, underscoring the need for accurately identifying modifiable risk factors.
There Is a Hole in My Bucky (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThere Is a Hole in My BuckyJan C. Hummelen, Maurizio Prato, and Fred WudlCite this: J. Am. Chem. Soc. 1995, 117, 26, 7003–7004Publication Date (Print):July 1, 1995Publication History Published online1 May 2002Published inissue 1 July 1995https://doi.org/10.1021/ja00131a024RIGHTS & PERMISSIONSArticle Views1038Altmetric-Citations209LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (781 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Test selection based on finite state models (1995)

A method for the selection of appropriate test case, an important issue for conformance testing of protocol implementations as well as software engineering, is presented. Called the partial W-method, it is shown to have general applicability, full fault-detection power, and yields shorter test suites than the W-method. Various other issues that have an impact on the selection of a suitable test suite including the consideration of interaction parameters, various test architectures for protocol testing and the fact that many specifications do not satisfy the assumptions made by most test selection methods (such as complete definition, a correctly implemented reset function, a limited number of states in the implementation, and determinism), are discussed. >