gebhart/patrepeval huggingface dataset:
Abstract B192: The EPR effect of CDP-tubulysin in the recurrence of lung and pancreatic cancers (2018)

Abstract Tubulysins, a tubulin-targeted class of natural compounds, are highly active in multidrug-resistant cells and potential agents to overcome clinical drug resistance in recurrent tumors. Unfortunately, the extraordinary activity of the potent tubulysins poses considerable complications for chemotherapeutic applications due to toxicity against normal cells and tissues. Nanoparticle drug delivery systems provide the potential to increase the intracellular concentration of drugs in cancer cells while avoiding toxicity in normal cells through the enhanced permeability and retention (EPR) effect. In this study, the efficacy of β-cyclodextrin-based polymeric tubulysin (CDP-tubulysin) administered by intravenous injection was tested on subcutaneous lung and pancreatic xenograft models. The single-dose pharmacokinetic study and tumor distribution of CDP-tubulysin and tubulysin alone were also determined in tumor-bearing mice. Our data demonstrated that CDP-tubulysin showed potent efficacy in treating lung and pancreatic cancers. The recurrent lung and pancreatic tumors were also regressed by treating with CDP-tubulysin but not gemcitabine. Moreover, the conjugation of CDP to tubulysin showed control-release behavior in the blood resulting in increased distribution of tubulysin in tumors. In conclusion, CDP conjugation was an effective delivery of tubulysins to avoid toxicity and provide potency in recurrent tumors through the EPR effect. Citation Format: Pei-Yi Tsai, Huei-Lin Jheng, Yen-Ju Hsieh, Yung-Jen Tsai, Michael Ahrweiler, Wolfgang Richter, Muhammad Abbas, Gianfranco Pasut, Jia-Ming Chang. The EPR effect of CDP-tubulysin in the recurrence of lung and pancreatic cancers [abstract]. In: Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2017 Oct 26-30; Philadelphia, PA. Philadelphia (PA): AACR; Mol Cancer Ther 2018;17(1 Suppl):Abstract nr B192.
Design Systems: A Community Case Study (2020)

Design Systems are an increasingly popular means for technology companies to improve development efficiency and design consistency across their products. In this case study, we present findings from a community-wide survey (n=1,513) and interviews at the Clarity 2019, a design systems conference. Our findings describe the community's evolving perception of what makes up a design system. We describe the members of the community who build and maintain these design systems. Our findings highlight i) the changing definition of design systems, ii) the practice of developing in-house design systems (in place of adopting an existing on one), and iii) the role of Design Systems in promoting collaboration between the Design and Engineering functions of a company.
Cytokine production in NOD mice on prophylactic insulin therapy (1999)

We investigated whether cytokines produced primarily by monocytes/macrophages (IL-1alpha), Th1-lymphocytes (IFNgamma), or Th2-lymphocytes (IL-4) are modulated in diabetes-prone NOD mice by insulin treatment as used in prophylaxis studies. The cytokines were measured by ELISA in plasma and in supernatants of spleen cells activated ex vivo by lipopolysaccharide plus phytohemagglutinin. Insulin, 0.25-0.50 IU/day, was given subcutaneously for 8 weeks starting in 4-week-old female mice. The insulin-treated and control NOD mice showed similar weight gains and, by the end of the study, both groups exhibited cell infiltration in about 25% of their islets. IL-1alpha, IFNgamma and IL-4 were generally below detection in plasma of prediabetic animals and controls. Diabetic NOD mice, aged 28-45 weeks, had significantly elevated plasma IL-1alpha: 154+/-39 pg/ml (mean+/-SEM, p<0.0001). While ex vivo activated NOD splenocytes released similar amounts of IL-1alpha, insulin therapy increased the levels from 99+/-17 to 155+/-19 pg/10(6) cells (p<0.05). Supernatants of activated splenocytes from prediabetic NOD mice had lower levels of IL-4 (<15 pg/10(6) cells) compared with those from BALB/c mice (88+/-22 pg/10(6) cells; p<0.01), and this deficiency was partially compensated for when the NOD mice were given insulin (27+/-8; p<0.01). The levels of IFNgamma were comparable and largely unaffected by insulin treatment. Hence, insulin therapy appears to partially normalize an otherwise deficient Th2 response in NOD mice.
A single shot of a hybrid hAdV5-based anti-COVID-19 vaccine induces a long-lasting immune response and broad coverage against VOC (2021)

ABSTRACT Most approved vaccines against COVID-19 have to be administered in a prime/boost regimen. We engineered a novel vaccine based on a chimeric hAdV5 vector. The vaccine (named CoroVaxG.3) is based on three pillars: i) high expression of Spike to enhance its immunodominance by using a potent promoter and a mRNA stabilizer; ii) enhanced infection of muscle and dendritic cells by replacing the fiber knob domain of hAdV5 by hAdV3; iii) use of Spike stabilized in a prefusion conformation. Transduction with CoroVaxG.3 expressing Spike (D614G) dramatically enhanced Spike expression in human muscle cells, monocytes and dendritic cells compared to CoroVaxG.5 that expressed the native fiber knob domain. A single dose of CoroVaxG.3 induced potent humoral immunity with a balanced Th1/Th2 ratio and potent T-cell immunity, both lasting for at least 5 months. Sera from CoroVaxG.3 vaccinated mice was able to neutralize pseudoviruses expressing B.1 (wild type D614G), B.1.117 (alpha) and P.1 (gamma) Spikes, as well as an authentic WT and P.1 SARS-CoV-2 isolates. Neutralizing antibodies did not wane even after 5 months making this kind of vaccine a likely candidate to enter clinical trials
Hydrodynamic study of fluidized bed of very dense powder: effects of reactor diameter reduction (2014)

The fluidized bed CVD (Chemical Vapor Deposition) process is very efficient for coating powders. However, its implementation requires that the powder to be treated has a good ability to fluidize, in order to ensure a good uniformity of deposition around each grain and to avoid any agglomeration phenomenon. This work aims to study the effects of a column diameter decrease on the hydrodynamic behavior of a powder of very high density, for different ratios between the fixed bed H0 and the column diameter D, and for columns in glass and steel.
Exact rainbow tensor networks for the colorful Motzkin and Fredkin spin chains (2019)

We present bulk tensor networks that exactly represent the ground states of a continuous family of one-dimensional frustration-free Hamiltonians. These states, which are known as area-deformed Motzkin and Fredkin states, exhibit a novel quantum phase transition. By tuning a single parameter, they go from a phase obeying an area law to a highly entangled ``rainbow'' phase, where the half-chain entropy scales with the volume. Using the representation of these ground states as superpositions of random walks, we introduce tensor networks for these ground states where local and global rules of the walker are baked into bulk tensors, thereby providing an efficient description of the ground states (some of which satisfy a volume law scaling of entanglement entropy).
Effects of Manganese Oxides/Gold Composite Electrode on Piezoelectric Properties of Lead Magnesium Niobate Titanate Single Crystal (2011)

We have confirmed a high dielectric constant after poling ε33T/ε0 of 7700 and piezoelectric constant d33 = 2250 pC/N, which are 40% larger than those of the initial sample, for a lead magnesium niobate–lead titanate 0.72 Pb(Mg1/3Nb2/3)O3–0.28 PbTiO3 single crystal plate with a manganese oxide/gold (Au) composite electrode. The increased ε33T/ε0 and d33 may be attributable to the smaller domains realized by fine patterning semiconductor manganese oxide and conductive Au composite electrodes on the single crystal plate. The use of a semiconductor/conductor composite electrode is an effective method of improving the properties of piezoelectric single-crystal transducers.
Recent Developments in the Chemistry of 2‐Alkyl‐2‐oxazolines and 2‐Alkyl‐2‐thiazolines (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
In Situ Quartz Crystal Microgravimetric Studies of Molecular Adsorbates Containing Thiol and Hydroquinone Moieties Bound to Au(111) Surfaces in Aqueous Electrolytes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn Situ Quartz Crystal Microgravimetric Studies of Molecular Adsorbates Containing Thiol and Hydroquinone Moieties Bound to Au(111) Surfaces in Aqueous ElectrolytesYibo Mo, Marnita Sandifer, Chaim Sukenik, Raul J. Barriga, Manuel P. Soriaga, and Daniel SchersonCite this: Langmuir 1995, 11, 12, 4626–4628Publication Date (Print):December 1, 1995Publication History Published online1 May 2002Published inissue 1 December 1995https://pubs.acs.org/doi/10.1021/la00012a007https://doi.org/10.1021/la00012a007research-articleACS PublicationsRequest reuse permissionsArticle Views109Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Biometric authentication system using retinal vessel pattern and geometric hashing (2016)

Retinal vascular network pattern is unique to each individual which can be used for person identification in biometric authentication. In this study, the authors have proposed a novel biometric authentication method using retinal vascular branch, bifurcation and crossover points (i.e. feature points). The method automatically extracts the vascular network from colour retinal images and identifies these feature points. The major blood vessels characterised by width and length are identified from the segmented vascular network. For this, a novel vessel width measurement method is applied and vessels more than certain widths are selected as major vessels following an established protocol. The geometric hashing technique is developed to compute the invariant features from these feature points. They consider the feature points from major vessels which will be less susceptible to noise for modelling a basis pair and all other points together for locations in the hash table entries. The models are invariant to rotation, translation and scaling as inherited from geometric hashing. For each person, the system is trained with the models to accept or reject a claimed identity. They have tested their method on 3010 retinal images and achieved 96.64% precision and 100% recall.
Local order in polycarbonate glasses by <sup>13</sup>C{<sup>19</sup>F} rotational‐echo double‐resonance NMR (2006)

Abstract Nearest‐neighbor chain packing in a homogeneous blend of carbonate 13 C‐labeled bisphenol A polycarbonate and CF 3 ‐labeled bisphenol A polycarbonate has been characterized using a shifted‐pulse version of magic‐angle spinning 13 C{ 19 F} rotational‐echo double‐resonance (REDOR) NMR. Complementary NMR experiments have also been performed on a polycarbonate homopolymer containing the same 13 C and 19 F labels. In the blend, the 13 C observed spin was at high concentration, and the 19 F dephasing or probe spin was at low concentration. In this situation, an analysis in terms of a distribution of isolated heteronuclear pairs of spins is valid. A comparison of the results for the blend and homopolymer defines the NMR conditions under which higher concentrations of probe labels can be used and a simple analysis of the REDOR results is still valid. The nearest neighbors of a CF 3 on one chain generally include a carbonate group on an adjacent chain. A direct interpretation of the REDOR total dephasing for the polycarbonate blend indicates that at least 75% of carbonate‐carbon 13 C ··· F 3 nearest neighbors are separated by a narrow distribution of distances 4.7 ± 0.3 Å. In addition, analysis of the variations in REDOR spinning‐sideband dephasing shows that most of the 13 C ··· F 3 dipolar vectors have a preferred orientation relative to the polycarbonate mainchain axis. This combination of distance and orientational constraints is interpreted in terms of local order in the packing of the carbonate group of one polycarbonate chain relative to the isopropylidene moiety in a neighboring chain. © 2006 Wiley Periodicals, Inc. J Polym Sci Part B: Polym Phys 44: 2760–2775, 2006
Suppression of time-varying resonances in the power supply line of AC locomotives by inverter control (1992)

The harmonic currents generated by the line-side converter of an electric locomotive are injected into the overhead supply system. Although low in magnitude, they give rise to traveling waves that start propagating in both directions along the overhead line. The traveling waves are reflected at various electrical discontinuities along the line such as the feeding substations and other traction vehicles, the positions of which are time varying. This produces eigenresonances at multiple frequencies. High resonant currents may be generated that cause problems of electromagnetic interference with railway communication and signaling systems. It is demonstrated that the time-varying eigenresonances can be identified in real time. Methods of optimal adaptive inverter control are employed in order to avoid the excitation of the line resonances.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
On the Capacity of Ultra Wideband Block Transmission Systems with Narrowband Interference Avoidance (2007)

In this letter, the theoretical capacities of single-carrier and multi-carrier block transmission systems that employ narrowband interference avoidance are derived. It is shown that the capacity of an OFDM system that implements active interference cancellation is degraded by approximately one bit per second per Hz at high SNR when 10% of the band is nulled. In contrast, the capacity of a single-carrier system that uses envelope scaling in the time domain to create deep frequency notches is not significantly affected by the nulling process.
Observations of multi-layered clouds using K-band radar (1993)

Rudimentary ground-based K-band radars were once used by the U.S. Air Force to monitor clouds over air bases. The NOAA wave Propagation Laboratory has developed a significantly advanced dual-polarization Doppler K-band system that provides remarkably detailed visualizations of the structure and kinematics of nonprecipitating and weakly precipitating clouds. Unlike lidar and infrared radiometer systems, K-band radar can penetrate liquid water cloud layers and obtain measurements through moderate rainfall and heavy snowfall to reveal intricate cloud features including multiple layers of cloud. This is accomplished at less cost than would be possible with traditional longer wavelength weather radars. The radar's capabilities have been demonstrated in several recent cloud research field projects. In combination with measurements by other remote sensors, the radar can help detect aircraft icing hazards and infer microphysical properties of clouds. An automated, unattended version of the radar could provide a continuous, detailed depiction of the cloud environment in the vicinity of airports.
A water‐soluble parthenolide analogue suppresses in vivo <i>prostate cancer</i> growth by targeting NFκB and generating reactive oxygen species (2010)

DMAPT promotes cell death by both generating ROS and inhibition of NFkappaB. Its in vivo activity supports the conduct of clinical trials in patients with castrate-resistant disease.
Protein Separations in Microfluidic Chips (2009)

Identifying protein structure, function, and expression level under varying environmental conditions in cells is an important activity in most life science research and pharmaceutical discovery. Determining the molecular weight and purity of protein samples is routinely done in laboratories using sodium dodecyl sulfate-polyacryamide gel electrophoresis (SDS-PAGE) in the last few decades (1, 2). This process is highly manual and takes many hours to prepare the gel, run the samples, stain and destain the protein fractions, capture the gel image, and analyze the image to determine the protein sizes against a ladder. With commercially available precast gel, the first step of the process is becoming simpler and less messy, but overall it is still a relatively slow and tedious procedure. In large-scale protein processing operations and proteomics research laboratories, protein analysis often is a bottleneck in the workflow. Over the last 10 years capillary gel electrophoresis-SDS (SDS-CGE) is being increasingly used for analysis of therapeutic proteins. Compared to SDS-PAGE, SDS-CGE offers advantages of on-column detection, improved quantitation and resolution, and automation. However, SDS-CGE is limited by low sensitivity, throughput, and reliability. In the past several years, microfluidic-based assay for sizing, quantitiation, and purity assessment of proteins are also finding rapid adoption. The benefits in integration, fast separation, automation, and ease of use offered by microfluidics address the limitations of SDS-PAGE and SDS-CGE, and have proven to be a faster and easier alternative to the traditional SDS-PAGE or SDS-CGE.
Impact of Varying Shares of Distributed Energy Resources on Voltage Stability in Electric PowerSystems (2019)

The increased power supply of distributed energy resources and the simultaneous reduced power supply or shutdown of conventional power plants are changing the dynamics of the power system. This paper investigates the impact of a varying share of distributed energy resources on system dynamics during a slow voltage collapse. Dynamic simulations are carried out to analyse how system dynamics change in different generation situations. Various reactive power strategies of distributed energy resources as well as reduced power supply of conventional generators are considered. The simulation results show that with a high share of distributed energy resources, their non-existent overload capability lead to a limitation of their reactive power, which can have a negative impact on voltage stability. However, these effects are less pronounced in less voltage-critical regions. Moreover, static reactive power supply as well as partially shut-downs of power plants and their earlier limitation by the overexcitation limiter can further destabilise the system.
Localisation intra-bâtiment multi-technologies (2005)

Indoor location-based applications have strong precision and scalability requirements that usually cannot be met by any single location-sensing technology. Combining the strong identification of RF-based location sensing with the accuracy of computer vision-based-tracking provides a powerful new solution for multi scale and multi-target indoor location sensing, without requiring dedicated infrastructures.
ChemInform Abstract: Chemistry in Superacids. Part 44. Theoretical Study of SiH<sub>2n</sub><sup>2+</sup> (n = 1—3) Dications. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Re: Salvage High-Intensity Focused Ultrasound for Patients with Recurrent Prostate Cancer after Brachytherapy (2015)

No AccessJournal of UrologyAdult Urology1 Jul 2015Re: Salvage High-Intensity Focused Ultrasound for Patients with Recurrent Prostate Cancer after Brachytherapy Samir S. TanejaMD Samir S. TanejaSamir S. Taneja More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.04.065AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Salvage High-Intensity Focused Ultrasound for Patients with Recurrent Prostate Cancer after Brachytherapy." The Journal of Urology, 194(1), p. 114 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 194Issue 1July 2015Page: 114Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Samir S. Taneja More articles by this author Expand All Advertisement PDF downloadLoading ...
All is not lost – the improving outcome of patients with chronic lymphocytic leukaemia failing frontline therapy with fludarabine, cyclophosphamide and rituximab (2013)

TEST 02 - Elsevier's Scopus, the largest abstract and citation database of peer-reviewed literature. Search and access research from the science, technology, medicine, social sciences and arts and humanities fields.
Lessons learned from a real vehicular network deployment of delay-tolerant networking (2015)

Vehicular networks are inherently unstable networks with high mobility and intermittent connectivity. These networks can greatly benefit from Delay Tolerant Networking (DTN) solutions for opportunistic connectivity in the transmission of delay-tolerant data. In this paper, we evaluate the performance of different DTN routing protocols in real world vehicular networks with different degrees of connectivity in order to understand their feasibility in real vehicular environments. Our case-study application is the upload of delay-tolerant sensing data from vehicular nodes to a server on the Internet. We deploy DTN in 3 vehicular testbeds: a heterogeneous lab testbed with controlled mobility, a low-mobility high-connectivity network of harbor trucks, and a high-mobility low-connectivity city bus network. We compare 3 routing protocols: epidemic, static and PRoPHET, for which we measure delivery ratio, average delay, path length, as well as transmission and storage overhead. We analyze the results for experimental insight, and extract lessons for DTN routing protocol design.
Characterization of AT2 angiotensin II receptors in rat anterior cerebral arteries (1991)

Quantitative autoradiography using the agonist 125I-Sar1-angiotensin II was used to localize and characterize angiotensin II (AT) receptors in the anterior cerebral artery of the male rat. This artery showed a moderately high number of AT receptors, localized throughout the arterial wall. The number of receptors was higher (125 +/- 7 fmol/mg protein) in arteries from young 2-wk-old rats compared with those in adult 8-wk-old rats (43 +/- 2 fmol/mg protein). In the anterior cerebral artery, AT binding was insensitive to displacement with the selective AT1 antagonist DuP 753 but was readily displaced by the selective AT2 antagonist CGP-42112 A (concentration eliciting 50% of maximum inhibition: 6 +/- 1 x 10(-10) M). This indicated that the AT receptors in the cerebral artery were of the AT2 subtype. Our observations suggest that AT may exert its effects on cerebral circulation by stimulation of AT2 receptors and that these receptors may play a role during cerebrovascular development.