gebhart/patrepeval huggingface dataset:
Control of transgene expression in mammalian cells (2005)

Abstract Spacio‐temporal adjustment of therapeutic transgene expression represents a fundamental technology for modern gene therapy since it enables precise in vivo dosing of protein therapeutics to manage an optimal therapeutic range, adaptation to specific disease dynamics, or resetting of molecular interventions as appropriate. Heterologous transcription control systems capitalizing on (1) prokaryotic antibiotic response regulons evolved to manage bacterial adaptation to macrolide, streptogramin, and tetracycline antibiotics, (2) (modified) hormone receptors specific for estradiol, progesterone, or ecdysone derivatives, or (3) chemically induced dimerization of protein domains prevailed in animal studies, and are currently considered for clinical trials. Since sustained administration of clinically licensed, small‐molecule drugs for transgene expression fine‐tuning may result in side effects, systems responsive to nucleic acids or physical parameters including light, temperature, and electromagnetic fields are in preclinical development.
Strength investigations on long oil gaps (2003)

We deal with the electrical strength properties of oil gaps. The investigations were carried out with uniform electrical fields and electrode distances up to 30 mm. Measurements were performed with alternating current (50 Hz), lightning impulses and switching impulses. Such investigations usually have a relative high dispersion of the measurement values. It will be shown that it is possible to minimize the coefficient of variation to values of about 5 to 6 percent.
Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children’s Study (2023)

The hygiene hypothesis suggests that pet exposure is effective in preventing allergic disease, and some studies have reported the beneficial effects of dog exposure during fetal development or early infancy on food allergy. However, the effects of exposure to pets other than dogs on the kinds of food allergies remains unaddressed. This study aimed to explore the effect of exposure to various species of pets on the risk of food allergies. We obtained information on pet exposure and food allergy from the Japan Environment and Children's Study, a nationwide, prospective birth cohort study that included 97,413 mothers and their children. We examined the associations between exposure to various species of pets during fetal development or early infancy and the incidence risk of food allergies. We conducted logistic regression analysis for each pet species, causative food, and timing of exposure. Exposure to dogs or cats during fetal development or early infancy was estimated to reduce the incidence risk of food allergies until the age of 3 years. Dog exposure was estimated to reduce the incidence risk of egg, milk, and nut allergies, and cat exposure was estimated to reduce the incidence risk of egg, wheat, and soybean allergies. However, hamster exposure was estimated to increase the incidence risk of nut allergy. In conclusion, the association between pet exposure and food allergies might differ depending on the pet species and causative food. Continued dog and cat exposure from fetal development to infancy was estimated to reduce the incidence risk of food allergies. The findings of this study shall aid in the design of future studies.
Normal B Cells Express <i>51p1</i>-Encoded Ig Heavy Chains That Are Distinct From Those Expressed by Chronic Lymphocytic Leukemia B Cells (2001)

51p1 is an allele of V(H)1-69 that frequently is expressed by chronic lymphocytic leukemia (CLL) B cells with little or no somatic mutation. The rearranged 51p1 genes expressed by CLL B cells have a distinctive use of D segments D3-3/DXP4 and D3-10/DXP'1, a favored use of J(H)6, and a longer third complementarity-determining region than the rearranged Ig genes used by CLL B cells that express V(H)1 genes other than V(H)1-69. We examined the 51p1-encoded Ig expressed by blood B cells of healthy donors. In contrast to the infrequent use of J(H)4 by 51p1-expressing CLL (e.g., 4%), 36% of the rearranged 51p1 sequences from normal blood B cells used J(H)4. Furthermore, the D segment use of the rearranged 51p1 sequences from normal blood B cells was not restricted, but reflected the D segment use of nonselected IgH of normal B cells. Finally, the mean length of the third complementarity-determining region for the 51p1 genes of normal blood B cells was 14.6 +/- 4.3 (SD) codons. This is significantly shorter than that noted for 51p1-expressing CLL B cells (18.8 +/- 3.2; p < 0.0001, n = 51). This study demonstrates that the 51p1-encoded IgH expressed in CLL are not representative of the 51p1-encoded IgH expressed by normal blood B cells, indicating that CLL B cells express IgH that are distinctive from those found in the normal adult blood B cell repertoire.
Secret-Sharing for NP from Indistinguishability Obfuscation (2014)

A computational secret-sharing scheme is a method that enables a dealer, that has a secret, to distribute this secret among a set of parties such that a qualified subset of parties can efficiently reconstruct the secret while any unqualified subset of parties cannot efficiently learn anything about the secret. The collection of qualified subsets is defined by a Boolean function. It has been a major open problem to understand which (monotone) functions can be realized by a computational secret-sharing schemes. Yao suggested a method for secret-sharing for any function that has a polynomial-size monotone circuit (a class which is strictly smaller than the class of monotone functions in P). Around 1990 Rudich raised the possibility of obtaining secret-sharing for all monotone functions in NP: In order to reconstruct the secret a set of parties must be qualified and provide a witness attesting to this fact. Recently, Garg et al. (STOC 2013) put forward the concept of witness encryption, where the goal is to encrypt a message relative to a statement in for a language L in NP such that anyone holding a witness to the statement can decrypt the message, however, if x is not in L, then it is computationally hard to decrypt. Garg et al. showed how to construct several cryptographic primitives from witness encryption and gave a candidate construction. One can show that computational secret-sharing implies witness encryption for the same language. Our main result is the converse: we give a construction of a computational secret-sharing scheme for any monotone function in NP assuming witness encryption for NP and one-way functions. As a consequence we get a completeness theorem for secret-sharing: computational secret-sharing scheme for any single monotone NP-complete function implies a computational secret-sharing scheme for every monotone function in NP.
A trainable graph combination scheme for belief propagation (2006)

Many problems in computer vision can be viewed as marginalization calculations in a probability distribution. Belief propagation is well suited for such calculations, but it suffers from several major limitations. Exact solutions are generally NP hard to compute, and approximate schemes can be difficult to set up and computationally expensive, and do not necessarily converge. Furthermore, parameter estimation is tedious, and precise tests of accuracy are not easily constructed. 
In this thesis, I propose a new approach to belief propagation that is both highly accurate and efficient. A given Markov random field is approximated by multiple sets of singly-connected graphs. Exact belief propagation on each set is then combined to yield a final set of marginal values. I demonstrate the approach in an image segmentation test case where optimal solutions are available from the maximum flow algorithm. The non-linear combination of information from each set of graphs improves greatly on the performance of each set alone and yields accuracy approaching the optimal. 
The graph combination scheme can additionally learn and optimize its parameters. This eliminates the manual selection of such parameters, which becomes increasingly difficult and inaccurate as the complexity of the problem grows. I demonstrate a learning scheme for a boundary-based image segmentation technique that combines the dual approaches of region and boundary segmentation. The system is trained on a set of pre-segmented images and yields convincing results while requiring only a fraction of the effort normally involved in setting up such a system.
Involvement of semaphorins and their receptors in neurological diseases (2010)

Abstract The immune and nervous systems have various common features in their functional characteristics. Both have an intricate network of synaptic connections and an exquisite communication system that enables intercellular signal transduction. Semaphorins were originally identified as guidance factors for developing neuronal axons. However, accumulating evidence indicates that several semaphorins called “immune semaphorins” are crucial for various phases of immune responses, from the initiation to the termination of inflammatory processes. Furthermore, it is becoming clear that immune semaphorins contribute to pathological immune responses in the central nervous system. Here, we review the present knowledge of the function of semphorins and their receptors in the immune system, and their involvement in the pathogenesis of neurological diseases. (Clin. Exp. Neuroimmunol. doi: 10.1111/j.1759‐1961.2009.00004.x, January 2010)
Investigating histomorphological variations in human cranial bones through ontogeny (2015)

Au cours de l&rsquo;ontogenèse, les os de la voûte crânienne humaine subissent une différenciation en termes de forme, de taille et de maturation de tissu. Cette différenciation est visible, non seulement au niveau macroscopique, mais aussi au niveau microscopique. Les données préliminaires d&rsquo;une analyse exploratoire histologique et de la compartimentation d&rsquo;individus d&rsquo;âges différents suggèrent des différences dans les schémas de modelage et de remodelage au cours de l&rsquo;ontogenèse. Les os de la voûte crânienne de l&rsquo;individu infantile sont composés principalement d&rsquo;os lamellaire (largement vascularisé), les os du juvénile ou de l&rsquo;adolescent présentent la plus large extension de zones minéralisées (os très remodelés) et la plus faible extension de vascularisation (le diploé est très réduit), et l&rsquo;adulte présente un tissu osseux très vascularisé, dans lequel le diploé est aussi très développé. Pendant l&rsquo;enfance, l&rsquo;existence d&rsquo;os lamellaire avasculaire favorise le scellement des surfaces des os du crâne, tandis que les os de la voûte des adultes semblent s&rsquo;ouvir ectocranialement, en raison du remodelage. Nous discutons de la possibilité que les deux effets soient liés à la thermorégulation de la tête.
Prostate-Specific Membrane Antigen Positron Emission Tomography/Computed Tomography in Locally Advanced, Recurrent, and Metastatic Prostate Cancer—Reply (2018)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Analytical Design of Permanent Magnet Radial Couplings (2010)

This paper presents a three-dimensional analytical approach for computing the torque transmitted by synchronous radial couplings with radially polarized tile permanent magnets. An expression is given as a finite sum of elliptic functions, which has no underlying simplificating assumptions. Such an expression allows parametric studies and optimizations of coupling structures. It is applied first to the study of conventional radial couplings. Then, structures with “short pitch” magnets are considered and compared with conventional ones. Eventually, special designs are presented, as the ones dedicated to screwing applications, for instance, which require creating an asymmetrical torque.
Reliability and failure analysis study of multi-die embedded micro wafer level packages (2010)

Main objective of this study is to design and development of multi-die embedded micro wafer level packages (EMWLP) reliability test vehicles. Such as, the laterally placed die EMWLP and the vertically stacked thin die EMWLP. For reliability evaluation, EMWLPs have been subjected to both environmental and mechanical reliability tests as per JEDEC standards. These reliability tests include highly accelerated stress testing (HAST), thermal Cycling (TC), moisture sensitivity testing level 3 (MSL3), board level TC and drop tests. In case of drop tests evaluation, two types of pad finishes, ENIG & OSP have been used. During reliability tests both test vehicles have exhibited better performance without any electrical failures. But in case of HAST reliability test, delamination issue in two packages have been observed. Detailed failure analysis has been carried out on delaminated packages to find out the root cause for the different modes of delamination failures. Non-destructive and destructive techniques have been employed to investigate the failures in EMWLP's and this includes electrical testing, Scanning Acoustic Microscopy (SAM), micro-sectioning and Scanning Electron Microscopy (SEM). Delamination interface has been identified as passivation-RDL interface. Thermo-mechanical simulation study has been carried out over both test vehicles to locate higher stress concentration regions in the packages and finally to correlate with experimental reliability and failure analysis results.
Diastolic Stress Test Echocardiography in Patients with Suspected Heart Failure with Preserved Ejection Fraction: A Pilot Study (2018)

The findings of this pilot study suggest that DST using E/e' ratio and TR velocity could be of potential usefulness to diagnose HFpEF during exercise in patients with suspected HFpEF at rest.
9-(4-Dimethylaminophenyl)-3,4,6,7,9,10-hexahydro-1,8(2<i>H</i>,5<i>H</i>)-acridinedione (1998)

The title compound, C21H24N2O2, contains an acridine moiety and a dimethylaminophenyl ring system. The side rings adopt half-chair conformations. The acridine chromophore is perpendicular to the substituted phenyl ring.
Assessment of coronary microvascular resistance in the chronic infarcted pig heart (2013)

Pre-clinical studies aimed at treating ischemic heart disease (i.e. stem cell- and growth factor therapy) often consider restoration of the impaired microvascular circulation as an important treatment goal. However, serial in vivo measurement hereof is often lacking. The purpose of this study was to evaluate the applicability of intracoronary pressure and flow velocity as a measure of microvascular resistance in a large animal model of chronic myocardial infarction (MI). Myocardial infarction was induced in Dalland Landrace pigs (n = 13; 68.9 ± 4.1 kg) by a 75-min. balloon occlusion of the left circumflex artery (LCX). Intracoronary pressure and flow velocity parameters were measured simultaneously at rest and during adenosine-induced hyperemia, using the Combowire (Volcano) before and 4 weeks after MI. Various pressure- and/or flow-derived indices were evaluated. Hyperemic microvascular resistance (HMR) was significantly increased by 28% in the infarct-related artery, based on a significantly decreased peak average peak flow velocity (pAPV) by 20% at 4 weeks post-MI (P = 0.03). Capillary density in the infarct zone was decreased compared to the remote area (658 ± 207/mm(2) versus 1650 ± 304/mm(2) , P = 0.017). In addition, arterioles in the infarct zone showed excessive thickening of the alpha smooth muscle actin (αSMA) positive cell layer compared to the remote area (33.55 ± 4.25 μm versus 14.64 ± 1.39 μm, P = 0.002). Intracoronary measurement of HMR successfully detected increased microvascular resistance that might be caused by the loss of capillaries and arteriolar remodelling in the chronic infarcted pig heart. Thus, HMR may serve as a novel outcome measure in pre-clinical studies for serial assessment of microvascular circulation.
UM-164: A Potent c-Src/p38 Kinase Inhibitor with <i>In Vivo</i> Activity against Triple-Negative Breast Cancer (2016)

In contrast with c-Src kinase inhibitors used in the clinic (1, 2), we demonstrate in vivo efficacy in xenograft models of TNBC. Our results suggest that the dual activity drug UM-164 is a promising lead compound for developing the first targeted therapeutic strategy against TNBC. Clin Cancer Res; 22(20); 5087-96. ©2016 AACR.
On-chip wideband tunable RF photonic phase shifter based on stimulated Brillouin scattering (2014)

We demonstrate for the first time an RF photonic phase shifter using stimulated Brillouin scattering on chip, with wide bandwidth operation. We achieve 180° phase shift range over 2-15 GHz frequency band.
April 2004 Report of Progress (2004)

Progress of each ALS-NSCORT project given by each project lead. 10 pages.
HDAC1 Governs Iron Homeostasis Independent of Histone Deacetylation in Iron-Overload Murine Models (2017)

Based on our results, we conclude that entinostat strongly activated hepcidin in vivo and in vitro. HDAC1 could serve as a novel hepcidin suppressor by binding to SMAD4, effect of which is independent of BMP/SMAD1/5/8 signaling. Antioxid. Redox Signal. 28, 1224-1237.
Bioinformatics-Based Predictions of Peptide Binding to Disease-Associated HLA Proteins Suggest Explanation for Shared Autoimmunity (2011)

Aim This study was designed to examine the immunogenetic basis for shared autoimmunity, resulting in autoantigen presentation that leads to the production of two or more disease-specific autoantibodies. Methods A bioinformatics approach based on peptide binding predictions to disease-associated HLA determinants has been developed and tested here using 11 disease associations between autoimmune systemic and mucocutaneous blistering disorders. Various HLAs associated with antigens within a given “disease model” (set of HLA class II and protein sequences known to be associated with a specific autoimmune disease) were tested and ranked against the antigenic proteins, first with proteins they are known to associate with and then with proteins known to be implicated in a second disease model. In every case binding predictions were compared for different proteins binding to the same HLA. Subsequently, disease-related autoantigens have been tested for their binding affinity against each disease-specific HLA class II protein. Results For a single HLA haplotype, several binders have been generated from a related autoantigen with the variable binding score. In most cases, the binding score corresponding to the interactions between the autoantigen-derived epitope and the HLA associated with one disease was similar or lower than the interactions between the epitope from proteins associated with the second disease and the same HLA. Notably, there was no compelling promiscuity in peptide binding to each of the HLA molecules, in spite of the promiscuous nature of HLA class II binding. Conclusions The data suggest that, in susceptible individuals, shared autoimmunity might be initiated by two types of HLA/peptide interaction; first between an autoantigen-derived epitope and its disease-associated HLA molecules, and second, between a different peptide of the same autoantigen and HLA proteins specific for the second disease.
Porous Metal Sheets of NiTi made by Wet Powder Spraying (2004)

Abstract As a promising method to produce thin porous NiTi sheets, Wet Powder Spraying (WPS) is applied for NiTi powders. Layers with a thickness of 150 μm are obtained from pre‐alloyed NiTi powders with a particle size of &lt; 12 μm. Optimized process control for spraying and sintering was used. Microstructure and phase formation is characterized. The sheets with a porosity of 15 % show a high pseudoelastic flexibility at room temperature. Phase transformation temperatures are determined by Differential scanning calorimetry (DSC). The one way effect could be demonstrated.
Cell Life Cycle Characterization Based on Generalized Morphological Parameters for Interferometric Phase Microscopy (2012)

We developed biological cell analysis tools for interferometric phase microscopy based directly on the quantitative phase profile and used them to characterize cancer-cell life cycle, and uniquely distinguish and predict the cell life cycle phases.
Long-haul microwave analog link with shot-noise-limited performance above the Stimulated Brillouin Scattering threshold (2008)

We have assembled and characterized a microwave frequency analog fiber link that offers shot-noise-limited performance at input powers above the stimulated Brillouin scattering threshold. The 20 km span of fiber consists of three pairs of alternating fibers, with each pair separated by isolators. The measured SBS threshold using the backscatter approach is 14 dBm; however, the measured relative intensity noise from 1-8 GHz remains at the shot-noise level until the input power exceeds 16 dBm. When compared to a single fiber link of the same length, the link gain, RF noise figure, and SFDR at 1 GHz all improve by 8.1 dB, 4.1 dB and 2.8 dB, respectively.