gebhart/patrepeval huggingface dataset:
Effects of vitamin C deficiency on physiology of male reproductive organs of guinea pigs. (1986)

Vitamin C dietary deficiency in guinea pigs markedly affected the androgen-sensitive parameters of the reproductive tissues--testis, epididymis, vas deferens, and accessory sex glands--and caused an "androgen-deprived effect" in these target organs. This in turn altered their internal milieu and caused changes in their metal ion profile and the morphology, motility, and density of spermatozoa in the cauda epididymis and vas deferens. The sensitivity of the vas deferens to adrenaline was also reduced in scorbutic guinea pigs, thus decreasing their fertility rate. The primary action seems to be at the level of the testis, and androgen deprivation and partial antifertility effects are probably secondary manifestations consequent to the primary effect. The present study demonstrated that ascorbic acid is essential for maintaining the physiological integrity of the androgen target reproductive organs in guinea pigs.
Polymerization of Antarctic Fish Tubulins at Low Temperatures: Role of Carboxy-Terminal Domains (1994)

We have proposed previously that the efficient polymerization of tubulins from Antarctic fishes at low, physiological temperatures (-1.8 to +2 degrees C) may result in part from adaptations (e.g., reductions in acidic residues) located in their carboxy-terminal (C-terminal) tails [Detrich & Overton (1986) J. Biol. Chem. 261, 10922-10930]. To test this hypothesis, we have examined the polymerization of Antarctic fish neural tubulins modified at their C termini by proteolysis or by neutralization of carboxyl groups. Addition of subtilisin to low concentrations of Notothenia coriiceps tubulin induced a biphasic assembly reaction: stage I corresponded to the C-terminal cleavage of beta chains to produce alpha beta s dimers, and stage II coincided with the slower, C-terminal cleavage of alpha chains to yield alpha s beta s. Both stage I and stage II polymers consisted of protofilament sheets and microtubules with attached sheets. The critical concentration for assembly of the stage II polymer was at least 10-fold lower than that of untreated tubulin. Neutralization of Glu and Asp carboxyls in Gobionotothen gibberifrons microtubules by the carbodiimide-catalyzed incorporation of glycine ethyl ester (GEE) moieties produced a tubulin, modified largely in its C termini, that assembled more readily than did control tubulin. When 12 GEE groups were incorporated per dimer, the critical concentrations for assembly of modified tubulin at 5-10 degrees C were 2-3-fold smaller than those for the unmodified protein. Comparably modified bovine tubulin (10 GEE/dimer) assembled at 37 degrees C with a critical concentration 2.6-fold lower than that for the unmodified tubulin.(ABSTRACT TRUNCATED AT 250 WORDS)
Stereochemical study on planar‐chiral cyclic molecules using polysaccharide‐based column chromatography (2022)

The presence of planar chirality of a variety of medium-sized heterocycles, along with nine-membered cyclic ketone and its enol ester, was revealed by observation of isolable enantiomers by analytical high-performance liquid chromatography (HPLC) using a chiral stationary phase with a polysaccharide-based chiral selector. Several tens of milligrams of enantiomers of the planar-chiral molecules were successfully separated by preparative-scale HPLC, leading to the preparation of an enantioenriched sample. This in turn enabled detailed stereochemical studies, including measurement of half-lives of the optical activity and X-ray crystallography for elucidation of stereochemistry.
Galileo OSNMA Public Observation Phase: Signal Testing and Validation (2022)

The Public Observation (PO) test phase of the Galileo Open Service Navigation Message Authentication (OSNMA) signal is officially opened since November <inline-formula xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> <tex-math notation="LaTeX">$15^{\text {th}}~2021$ </tex-math></inline-formula> , by the European Union Agency for the Space Programme (EUSPA). During this phase, any interested users is allowed to access the Signal in Space (SIS) for testing purposes, while the crypto material needed to process the message and verify its authenticity is made available on the European GNSS Service Centre (GSC) web portal. This paper describes the processing of the Galileo E1-B navigation message, as observed during the first days of PO. The purpose is to analyze the crypto and authenticated data carried by the SIS and apply the OSNMA protocol to authenticate the navigation message. The SIS has been processed with the NGene real time software receiver which verifies the authenticity of the navigation data, before evaluating the position fix. The work is completed by an assessment of OSNMA-ready receiver performance, mainly in terms of position accuracy.
ChemInform Abstract: A NOVEL SYNTHESIS OF ARYL ORTHOESTERS: TRIMETHYL M‐IODOORTHOBENZOATE (1980)

Abstract 3‐Iod‐ benzoylchlorid (Ia) bzw. 3‐Iod‐benzoesäureester (Ib) reagieren in Gegenwart von Aluminiumchlorid mit Ethylmercaptan zu den Aryl‐orthothioestern (II), die mit Methanol zu den Orthoestern (III) umgeestert werden.
Toxic corneal oedema associated with amantadine use (2009)

Amantadine HCl is an antiviral agent used to treat and prevent influenza A. It is also indicated for the treatment of Parkinsonism and drug-induced extrapyramidal symptoms.[1] Off-label uses include multiple sclerosis, Alzheimer disease and attention-deficit/hyperactivity disorder (ADHD). We report two patients with reversible, profound visual loss and corneal oedema associated with amantadine use.

### Case 1

A 12-year-old girl with generalised anxiety …
Pitavastatin-Incorporated Nanoparticles for Chronic Limb Threatening Ischemia: A Phase I/IIa Clinical Trial (2021)

This is the first clinical trial of pitavastatin-incorporated nanoparticles in patients with CLTI. Intramuscular administration of NK-104-NP to the ischemic limbs of patients with CLTI was safe and well tolerated and resulted in improvements in limb function.
ChemInform Abstract: Synthesis of Ceratinamine and Moloka′iamine: Antifouling Agents from the Marine Sponge Pseudoceratina purpurea. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
cURL and Postman (2019)

cURL is a command line tool for getting or sending files using the URL syntax. cURL supports a range of common Internet protocols like HTTP, HTTPS, FTP, FTPS, SCP, SFTP, TFTP, and LDAP, out of which HTTP is of interest for our discussions in this book.
Constitutive expression of the global regulator AbrB restores the growth defect of a genome-reduced <i>Bacillus subtilis</i> strain and improves its metabolite production (2022)

Partial bacterial genome reduction by genome engineering can improve the productivity of various metabolites, possibly via deletion of non-essential genome regions involved in undesirable metabolic pathways competing with pathways for the desired end products. However, such reduction may cause growth defects. Genome reduction of Bacillus subtilis MGB874 increases the productivity of cellulases and proteases but reduces their growth rate. Here, we show that this growth defect could be restored by silencing redundant or less important genes affecting exponential growth by manipulating the global transcription factor AbrB. Comparative transcriptome analysis revealed that AbrB-regulated genes were upregulated and those involved in central metabolic pathway and synthetic pathways of amino acids and purine/pyrimidine nucleotides were downregulated in MGB874 compared with the wild-type strain, which we speculated were the cause of the growth defects. By constitutively expressing high levels of AbrB, AbrB regulon genes were repressed, while glycolytic flux increased, thereby restoring the growth rate to wild-type levels. This manipulation also enhanced the productivity of metabolites including γ-polyglutamic acid. This study provides the first evidence that undesired features induced by genome reduction can be relieved, at least partly, by manipulating a global transcription regulation system. A similar strategy could be applied to other genome engineering-based challenges aiming toward efficient material production in bacteria.
Field Test of Cyclodextrin for Enhanced In-Situ Flushing of Multiple-Component Immiscible Organic Liquid Contamination: Comparison to Water Flushing (1999)

A pilot-scale field experiment was conducted to compare the remediation effectiveness of an enhanced-solubilization technique to that of water flushing for removal of multicomponent nonaqueous-phase organic liquid (NAPL) contaminants from a phreatic aquifer. This innovative remediation technique uses cyclodextrin, a sugar (glucose)-based molecule, to enhance the apparent aqueous solubility of organic contaminants. The cyclodextrin solution significantly increased not only the apparent solubility for several target contaminants, but also the rate of dissolution. As a result of these effects, the time required for cleanup of NAPL contamination at this field site may be greatly reduced by using cyclodextrin-enhanced flushing. For example, it was estimated that more than 70,000 pore volumes of water flushing would be required to remove the undecane mass that was removed in the 8-pore volume cyclodextrin flush, and for trichloroethene, which exhibited the smallest solubility enhancement, about 350 pore volumes of water flushing would be required.
Phalaris canariensis L. (2000)

https://thekeep.eiu.edu/herbarium_specimens_byname/4327/thumbnail.jpg
Current Status of the COFFE Solver within HPCMP CREATE<sup>TM</sup>-AV Kestrel (2020)

Recent development for United States Department of Defense HPCMP CREATE™-AV Kestrel component COFFE has led to significant speed, robustness, and work-flow improvements. Significant speed-up is achieved through vectorization pragmas and compiler options; robustness is improved through the adoption of a new pressure-based shock switch and slight modification to the negative side of the SA-neg turbulence model; and post-processing work-flow is enhanced with the addition of dimensional outputs and Kestrel taps. These improvements are demonstrated through efficient and accurate simulations across a variety of geometries and flow conditions, including a high-speed cylinder, a double cone, an F/A-18 fighter, the Common Research Model, and the JAXA Standard Model. Furthermore, linear CPU strong scaling is demonstrated for up to 7,128 cores for a grid made up of 49,073,713 nodes.
Novel design concept and technologies of the switching mode circuit based on the electromagnetic wave theory and the nonlinear undulation theory (2010)

This paper presents the novel concept of the generation mechanism of the solitary electromagnetic wave (SEMW) by the switching device. The SEMW concept is formed by fusing the electromagnetic wave (EMW) theory and the nonlinear undulation theory. The behavior of the SEMW on the PL and the SL are explained. The low impedance lossy line (LILL) technology and the matched impedance lossy line (MILL) technology were developed based on the SEMW concept. The design examples of the on-chip LILL and the MILL, and the effectiveness of them are also presented.
The Suppression of Metastases and the Change in Host Immune Response after Low-Dose Total-Body Irradiation in Tumor-Bearing Rats (1999)

We have shown that metastasis is suppressed by low-dose total-body irradiation (TBI) in tumor-bearing rats. We have evaluated the immunological effects of low-dose TBI. Total-body irradiation with 0.2 Gy was given 14 days after the implantation of 5 x 10(5) allogenic hepatoma cells (KDH-8) which produce transforming growth factor beta (TGF-beta). On day 21, the splenocytes and tumor-tissue infiltrating lymphocytes were analyzed by FACScan and RT-PCR for the mRNA of the genes that encode tumor necrosis factor alpha (TNF-alpha), interferon gamma (IFN-gamma), TGF-beta, interleukin (IL)-4, IL-10 and IL-6. The same procedure was conducted with untreated rats and with rats that underwent local irradiation with 0.2 Gy. The low-dose TBI significantly decreased the incidence of lung and lymph node metastasis (P < 0.01), whereas the same dose of local irradiation had no effect on the incidence of metastasis. The proportion of CD8+ cells in splenocytes increased in the low-dose TBI group (P < 0.01) compared to the locally irradiated and the untreated groups. The tumor-tissue infiltrating lymphocytes were also significantly increased after low-dose TBI (P < 0.01). The FACScan analysis revealed that 72% of the tumor-tissue infiltrating lymphocytes were CD8+. In both spleen and tumor tissue after low-dose TBI, mRNA expression of the genes that encode IFN-gamma and TNF-alpha increased, while that of the Tgfb gene decreased. There was no expression of the mRNAs of the Il4, Il6 and Il10 genes. CD8+ cells and the cytokine network may play an important role in the antitumor effect of low-dose TBI.
Methotrexate-related lymphoproliferative disorders in the liver: Case presentation and mini-review (2019)

The information obtained from our case and a review of 9 additional cases reported thus far assist physicians who may face the challenge of diagnosing and managing this disorder.
Knudsen cell mass spectrometric investigation of the PbO-ZrO2-TiO2 system (1999)

Knudsen effusion mass spectrometry (KEMS) was used for direct determination of lead oxide activity as a function of temperature in various regions of the PbO-ZrO(2)-TiO(2) system. From the results, the enthalpy, Gibbs free energy and entropy of formation of PbTiO(3) (PT), PbZrO(3) (PZ) and Pb(Zr,Ti)O(3) (PZT) were evaluated. In addition, the single phase widths of Pb(Zr(0.5)Ti(0.5))O(3) and PbTiO(3) perovskite structures were determined at 1100 K. The reaction rate of PZT synthesis in vacuo was followed by direct measurement of the change of PbO activity with time. Lead oxide activity in stoichiometric Pb(Zr(0.5)Ti(0.5))O(3), PbTiO(3) and Pb(0.968)(Zr(0.5)Ti(0.5))O(2.968) (3% lead deficient) at 850 degrees C was found to be 0.40, 0.45 and 0.1, respectively. PZT, PT and PZ powder samples prepared by a solid state procedure were also measured, all revealing lead deficiency. Copyright 1999 John Wiley & Sons, Ltd.
Dataset supporting the paper entitled "Thermally-Aware Composite Run-Time CPU Power Models" (2016)

This dataset supports the paper entitled “Thermally-Aware Composite Run-Time CPU Power Models” accepted for PATMOS, 2016.
Discriminative stimulus properties of (±)-fenfluramine: The role of 5-HT₂ receptor subtypes. (2003)

The role of serotonin 5-HT2 receptors (5-HT2R) in the discriminative stimulus effects of fenfluramine was investigated. Male Sprague-Dawley rats were trained to discriminate (+/-)-fenfluramine (2 mg/kg ip) from saline using a 2-lever, water-reinforced paradigm. Drug-lever responding after fenfluramine was dose-dependent. The 5-HT(2C/1B)R agonist mCPP and the 5-HT(2C)R agonist MK 212 fully substituted, whereas the 5-HT(2A/2C)R agonist DOI partially substituted, for the training drug. The 5-HT(2B)R agonist BW 723C86 engendered saline-lever responding. The 5-HT(2C/2B)R antagonist SB 206553 completely antagonized the fenfluramine discrimination a well as the full substitutions of mCPP and MK 212 and the partial substitution of DOI. The selective 5-HT(2A)R antagonist M100907 partially suppressed the stimulus effects of fenfluramine, mCPP, and MK 212 and almost fully attenuated the partial substitution of DOI. RS 102221, a selective 5-HT(2C)R antagonist that does not cross the blood-brain barrier, did not alter the fenfluramine cue. Results demonstrate that the discriminative stimulus effects of fenfluramine are centrally mediated by 5-HT(2C)R and to some extent by 5-HT(2A)R.
Aminoglycosides are useful for severe respiratory tract infections. (1997)

Clinical trials comparing the efficacy of monotherapy with aminoglycosides versus beta-lactams suggest that standard multiple-daily dosing regimens of aminoglycosides are less effective than the newer broad-spectrum beta-lactams, especially against Pseudomonas aeruginosa. However, the addition of an aminoglycoside to a beta-lactam has increased survival in patients with gram-negative bacteremia, particularly in those with hypotension and severe illness. This reduction in mortality has not yet been observed with other popular combinations, such as the fluoroquinolones with beta-lactams. The ability of aminoglycosides to prevent the emergence of resistance is less well documented. Newer studies on the pharmacodynamics of antimicrobials have shown that once-daily dosing optimizes the efficacy and minimizes the toxicities of aminoglycosides. Meta-analyses of large numbers of clinical trials have suggested that this method of drug administration can facilitate the increased usage of the aminoglycosides while limiting nephrotoxicity and the cost of antimicrobial therapy. The use of aminoglycosides by once-daily dosing for adjunctive therapy in severe respiratory tract infections is both efficacious and safe.
Chemical, Thermo-Mechanical and Antimicrobial Properties of DBD Plasma Treated Disinfectant-Impregnated Wipes during Storage (2019)

Disinfectant-impregnated wipes are broadly used in hospitals, as an important approach for infection prevention and control. But their ageing performance has rarely been studied. Untreated and Dielectric Barrier Discharge (DBD) plasma pre-treated wiping materials made of nonwoven 100% polyester (W1), nonwoven 55% cellulose/45% polyester (W2) and woven cotton (W3) were impregnated with a quaternary ammonium compound solution (ADBAC) for 30 min, 3, 7, 15, and 30 days of storage time and characterized in term of chemical, thermo-mechanical and antimicrobial efficacy. X-ray photoelectron spectroscopy analysis on the plasma-treated polyester wipes demonstrates the incorporation of reactive oxygen species on the fiber surface. Laser scanning microscopy demonstrates the plasma etching effect in smoothing the surface of the cotton wipe reducing the adsorption of ADBAC. The result showed no significant changes in breaking force and elongation during storage for W1 and W2. However, plasma treatment affects W3 in weft direction reducing the force at break in water and ADBAC treated wipes. Dynamic mechanical analysis results show that ADBAC and plasma treatment have a significant influence in W1 and W3 viscoelastic properties improving the elastic response limiting the polymeric chains mobility and the non-elastic response due to the etching effect, respectively. Overall, the plasma pre-treatment of ADBAC-impregnated wipes is able to enhance the antimicrobial performance and the storage time of polyester-containing wipes.
Fabrication of disk droplets and evaluation of their lasing action (2017)

Disk resonators are difficult to create with droplets, since they self-form spheres due to the surface tension. In this study, disk (cylindrical) droplets were created by enclosing a dye (rhodamine 6G) solution in silicone rubber. Lasing actions of these droplets were examined by pulsed green laser excitation. In a large droplet (2 mm diameter), the whispering gallery mode emission was difficult to attain, since it competed with the radial or axial modes that made a round trip in the droplet. A disk droplet of 150 μm diameter exhibited a comb-like spectrum of the whispering gallery mode resonant emission.
Inhibitory Effect of Yogurt on Production of Indole, Phenol and Ammonia by Intestinal Bacteria. (1993)

腸内細菌による腐敗産物生成に及ぼすヨーグルトおよびその成分の影響を, in vitro系で調べることを目的とし, インドール産生菌としてE. coli 0-601, アンモニア産生菌としてP. mirabilis 7082ならびにフェノール産生菌としてCl. perfringens 7083株をそれぞれ選択し, 検討した。3%のヨーグルトホエーを添加することにより, 0-601株のインドール産生量は著しく低減しtryptophanase活性も低くなることがわかった。これは, ヨーグルトから培地中に移行した乳糖によるtryptophanaseのリプレッションおよび培地pHの低下による影響と推察された。しかし, ヨーグルトホエーよりも乳糖量の高い発酵前のミックスを添加した際は, ヨーグルトホエーを添加したものと培地pHが同等であるにもかかわらず, インドール産生量が高いことから, ヨーグルトホエー中には乳糖以外にもインドール産生抑制作用を示す物質があるものと推察された。一方, 尿素無添加培地では, 3%のヨーグルトホエーの添加により7082株によるアンモニア産生が若干抑制された。7082株はureaseの他に, アルギニン, ロイシン, アスパラギン酸, アスパラギン等のアミノ酸を加水分解してアンモニアを生成する脱アミノ酵素を有していることを認めた。とくにアスパラギン脱アミノ酵素活性が最も高く, アスパラギンのみを窒素源とした最少培地を用いても高濃度のアンモニアが生成された。また, 7082株のアンモニア生成酵素 (とくにurease) は低pHに対して感受性が高く, pH低下により活性がいずれも減少した。したがって, 尿素無添加培地にヨーグルトホエーを加えた際のアンモニア生成の抑制は, 培地pHの低下に伴って7082株のアミノ酸脱アミノ酵素等の活性が低下したことによると推察された。一方, 7083株に対するフェノール生成抑制効果は, ヨーグルトホエーの添加ではまったく認められなかったが, ヨーグルトを添加した際に若干その効果が認められた。ヨーグルト添加培地の培養後のpHが, 無添加もしくはヨーグルトホエー添加培地より約0.6低かった。ヨーグルト由来の乳酸菌の増殖により培地pHが低下し, フェノール生成が抑制されたものと推察される。
Transplantation of a quaternary structure neutralizing antibody epitope from dengue virus serotype 3 into serotype 4 (2020)

Dengue vaccine trials have revealed deficits in our understanding of the mechanisms of protective immunity, demonstrating a need to measure epitope-specific antibody responses against each DENV serotype. HmAb 5J7 binds to a complex, 3-monomer spanning quaternary epitope in the DENV3 envelope (E) protein, but it is unclear whether all interactions are needed for neutralization. Structure guided design and reverse genetics were used to sequentially transplant larger portions of the DENV3-specific 5J7 mAb epitope into dengue virus serotype 4 (DENV4). We observed complete binding and neutralization only when the entire 3 monomer spanning epitope was transplanted into DENV4, providing empirical proof that cooperative monomer-hmAb 5J7 interactions maximize activity. The rDENV4/3 virus containing the most expanded 5J7 epitope was also significantly more sensitive than WT DENV4 to neutralization by DENV3 primary immune sera. We conclude that the hinge-spanning region of the 5J7 quaternary epitope is a target for serotype-specific neutralizing antibodies after DENV3 infection.
Energy Transfer in the Restricted Geometry of Lamellar Block Copolymer Interfaces (2001)

We carried out simulations of energy transfer kinetics for lamellar block copolymer systems in which donor and acceptor dyes were attached to the block junctions. We considered blocks of homopolymers that were sufficiently immiscible and of sufficiently high molecular weight to employ the Helfand−Tagami distribution of block junctions. The morphology of such block copolymers has been frequently discussed in terms of an apparent dimension parameter, which is recovered from the analysis of fluorescence decay curves, using the Klafter−Blumen (KB) formalism. Here, we investigate how such apparent dimensions are influenced by the interface thickness between the two blocks (which is dependent on the Flory−Huggins χ parameter of the system). We also probe the dependence of this apparent dimension on the concentration of the dyes in labeled samples. This kind of dependence has been experimentally observed but never explained, perhaps because of the approximations inherent in using the KB model to analyze fluorescent decay curves for block copolymer systems. We have found that apparent dimensions approach three for reasonably broad interfaces, but decrease to near two for very narrow interfaces, in accordance with asymptotic formulas that we propose for strongly segregated, lamellar block copolymer melts. Global analysis of the decay curves, as well as weighted linear regression of the parameters obtained from individual analyses of the decays, suggest linear relationships between the apparent dimensions from KB analyses and acceptor concentrations. We discuss the dependence on interface thickness in terms of the basic (Förster) theory of direct energy transfer, and indicate why the KB model is a reasonable representation of lamellar block copolymers.