gebhart/patrepeval huggingface dataset:
Epidermal growth factor receptor and claudin‐2 participate in A549 permeability and remodeling: Implications for non‐small cell lung cancer tumor colonization (2008)

Tumor colonization involves changes in cell permeability and remodeling. Paracellular permeability is regulated by claudins, integrated tight junction (TJ) proteins, located on the apicolateral portion of epithelial cells. Epidermal growth factor (EGF) was reported to modify cellular claudin levels and induce remodeling. To investigate a role for EGF receptor (EGFR) activation in tumor colonization we studied the effect of EGF and claudin-2 overexpression on permeability and cell reorganization in the human A549 non-small cell lung cancer (NSCLC) cell line. Our data demonstrated that A549 cells possess functional TJs and that EGF treatment increased levels of claudin-2 expression by 46%. Furthermore, EGFR signaling reduced monolayer permeability to choline and triggered cellular remodeling. The mitogen-activated protein kinase inhibitor PD98059 blocked the effect on A549 permeability and remodeling. EGF stimulation also exacerbated a fourfold increase in cell colonization elicited by claudin-2 upregulation. Our findings are consistent with the hypothesis that EGFR signaling plays an important role in A549 cell physiology and acts synergistically with claudin-2 to accelerate tumor colonization. Understanding the influence of EGF on A549 cell permeability and reorganization will help shed light on NSCLC tumor colonization and contribute to the development of novel anti-cancer treatments.
Neural Network Dynamics Models for Control of Under-actuated Legged Millirobots. (2017)

Millirobots are a promising robotic platform for many applications due to their small size and low manufacturing costs. However, controlling these millirobots is difficult due to their underactuation, power constraints, and size. While hand-engineered controllers can sometimes control these millirobots, they often have difficulties with highly dynamic maneuvers and complex terrains. We present a learning based approach in which a model of the dynamics is learned from data gathered by the millirobot, and that data is then leveraged by an MPC controller. We show that with 17 minutes of random data collected with the VelociRoACH millirobot, the VelociRoACH can accurately follow trajectories at higher speeds and on more difficult terrains than a differential drive controller. Experiment videos can be found at this https URL
Air stable black phosphorous in polyaniline-based nanocomposite (2017)

The greatest challenge regarding black phosphorus (BP) comes as a result of its fast degradation when exposed to ambient conditions, which has overshadowed its applications. Herein, we report a simple and efficient route towards overcoming BP deterioration by preparing a nanocomposite with the conducting polymer polyaniline (PANI). The liquid/liquid interfacial method was employed to produce transparent, freestanding and transferable thin film of BP covered by PANI, with high stability under ambient atmosphere, up to 60 days. Otherwise, the uncapped exfoliated neat BP degraded in solely 3 days under the same conditions. Characterization data show that PANI covers efficiently the BP flakes, indicating favorable interactions between the components. The results presented here can be considered a breakthrough for employing BP as thin film in different technological applications, considering the properties of BP itself or taking advantage of synergistically combining the properties of both components.
Strain control in nucleophilic cyclizations: reversal of <i>exo</i>‐selectivity in cyclizations of hydrazides of acetylenyl carboxylic acids by annealing to a pyrazole scaffold (2012)

Independent of the nature of alkyne substitution, hydrazides of 4‐arylethynyl‐5‐carboxylic acid annealed at the pyrazole scaffold undergo a regioselective base‐catalyzed 6‐ endo‐dig cyclization with the formation of pyrazolo[3,4‐c]pyridine‐7‐ones. This behavior contrasts the observation of selective 5‐ exo closures in the analogous benzannelated systems and illustrates selective destabilization of the reaction path leading to the formation of a smaller ring. Computational analysis also reveals an important role of prototropic equilibria in rendering the overall cyclization feasible in the strained heterocyclic systems. The switch to the formation of a larger cycle suggests that strategic incorporation of strain can be used as a tool for the efficient control of regiochemistry of nucleophilic cyclizations. Copyright © 2012 John Wiley &amp; Sons, Ltd.
Lesson study na formação de professores do 1.º ciclo do ensino básico (2012)

Esta comunicação tem por base uma experiência de lesson study em Matemática, no 1.º ciclo, num agrupamento de escolas de tipologia híbrida do Projeto Mais Sucesso Escolar. O lesson study, que contempla a preparação e observação da aula e a reflexão pós-aula, baseia-se no trabalho colaborativo entre professores, favorecendo a reflexão sobre os processos de aprendizagem dos alunos e as suas dificuldades. Nesta comunicação, apresentamos uma experiência realizada no 4.º ano que incidiu no conceito de ângulo, tendo como objetivo identificar as aprendizagens profissionais realizadas pelos professores envolvidos. A metodologia de investigação é qualitativa e interpretativa, sendo a recolha de dados feita por registo de observação em notas de campo, gravação vídeo e reflexões escritas das professoras participantes. O balanço global da experiência é francamente positivo pelas aprendizagens profissionais realizadas relativamente ao tópico lecionado, às tarefas a selecionar e à condução da aula, bem como pelo estímulo dado a uma atitude reflexiva na prática docente.
High Gain Conical Horn Antenna Integrated With a Planar Substrate for 60 GHz WPAN Applications (2010)

International audience
Abstract #3392: Transient pAkt increase after chemo exposure predicts strength of synergy for combinations of the PI3K inhibitor GDC-0941 and chemotherapeutics (2009)

AACR Annual Meeting-- Apr 18-22, 2009; Denver, CO

The PI3K/PTEN pathway is frequently disrupted in cancer cells and is implicated in multiple aspects of tumor growth and survival. Inhibition of this pathway therefore represents a rational target for therapeutic intervention. Resistance to many anticancer agents has been attributed to a failure to decrease PI3K/PTEN pathway signaling resulting in cell survival. Hence, inhibitors of the pathway have potential utility both as single agents and in combination with other targeted and cytotoxic therapies. In these studies we have explored the use of a Class I PI3K inhibitor, GDC-0941, in combination with chemotherapeutics. We have found in many cases that inhibition of PI3K significantly enhances the effects of chemo in vitro. Analysis of combinations using viability assays in multiple cell lines indicated that pathway mutational status was not strongly associated with synergy. Instead, we discovered that increased nuclear pAkt in response to the chemotherapeutic as a single agent was often predictive of the strength of synergy with GDC-0941. This correlation did not depend on endogenous levels of pAkt. We also found that pAkt levels were decreased upon GDC-0941 dosing regardless of the presence or absence of the chemo and regardless of whether the combinations were synergistic or not. Overall, these results suggest that chemo combinations involving PI3K inhibitors should be efficacious in vivo.

Citation Information: In: Proc Am Assoc Cancer Res; 2009 Apr 18-22; Denver, CO. Philadelphia (PA): AACR; 2009. Abstract nr 3392.
A resonant-commutated-link variable-frequency converter (1998)

A novel DC-link converter utilizing resonant commutation is presented. Since resonant commutation is accomplished, converter switches are thyristors (SCRs) with lower costs than forced commutated devices. Focus is on the variable-frequency operation of the converter, with potential application in variable-frequency custom power delivery or adjustable-speed motor drives. The converter operates with greater stored energy in the DC link, thus offering current holdup capabilities during a contingency which cannot be attained with a conventional resonant DC-link converter and achieves minimum switching losses without increased conduction losses. Harmonic elimination is achieved by employing sinusoidal pulsewidth modulation (SPWM) control of the converter. Simulation results and experimental validation of the resonant commutation of a low-voltage and low-power laboratory model are discussed. Work in progress and the scope of further work are discussed.
Supplemental Figure Legends from Androgen Receptor Supports an Anchorage-Independent, Cancer Stem Cell-like Population in Triple-Negative Breast Cancer (2023)

&lt;p&gt;Supplemental Figure Legends&lt;/p&gt;
Physical modelling of point-cloud (3D) and full-wave-form (4D) laser imaging (2010)

We compare results issued from a numerical model that simulates the point cloud obtained by 3D laser scanning of a
scene and measurements provided by a commercial laser scanner. The model takes into account the temporal and
transverse characteristics of the laser pulse, the propagation through turbulent and scattering atmosphere, the interaction
with the objects of the scene (which have special optical properties: BRDF...) and the characteristics of the opto-electric
detection system. The model derives 4D laser imaging information as temporal laser backscattered intensity (full wave
form) is considered here. Experiments and simulations are performed on targets and scenes in order to test the
performances of such imager under conditions that could be representative of future applications like Sense and Avoid,
Target Recognition and Mapping,...
IL-6 has no acute effect on the regulation of urea synthesis<i>in vivo</i>in rats (2010)

IL-6 is not the mediator of the in vivo CUNS up-regulation observed 3 h after TNF-α administration, but it may be involved in the down-regulation of urea cycle genes. IL-6 may also mediate TNF-α effects on acute phase protein gene expression. Thus, IL-6 did not contribute to the in vivo hepatic component of inflammation-associated catabolism.
Atomic Layer Deposition of NbC-Al2O3 Composite Films for Efficient Solar Selective Coatings (2017)

Solar selective films hold great promise for improving the efficiency of concentrated solar power (CSP) facilities. In this study, we used atomic layer deposition (ALD) to prepare solar selective films composed of metal-dielectric nanocomposites with tunable optical and electronic properties. We used niobium carbide (NbC) as the metallic component and Al2O3 as the dielectric component of the nanocomposite films, and these components were blended at the atomic scale by alternating between the NbC and Al2O3 ALD processes. In-situ quadrupole mass spectrometry and quartz crystal microbalance (QCM) measurements were performed to examine the growth of the NbC-AlO composite films as well as to establish the NbC ALD growth mechanism. These measurements revealed that the NbC inhibited the Al2O3 ALD, while the Al2O3 enhanced the NbC ALD. Next, NbC-AlO nanocomposite films wereprepared over the full range of 0-100% NbC in Al2O3 and the physical, optical and electrical properties were measured. We discovered that the band gap and electrical resistivity could be precisely tuned by controlling the composition, and that higher NbC contents yielded a lower band gap and a smaller resistivity. Based on the absorption spectra of the NbC-AlO composite films, we established that 10-20% NbC yield the highest selective absorption efficiencies due their high visible light absorption and low infrared absorption. However, the selective absorption properties of the NbC-AlO composite films were lost upon annealing to 400°C in air as a result of oxidation of the NbC. Our study demonstrates the efficacy for ALD preparing metal-dielectric nanocomposite films with tunable properties to achieve a high selective absorber efficiency. By applying this technique to more thermally robust metallic materials we hope to produce solar selective coatings suitable for deployment in CSP facilities.
Renin–angiotensin system in intestinal inflammation—Angiotensin inhibitors to treat inflammatory bowel diseases? (2021)

Inflammatory bowel diseases (IBDs) are chronic disorders of the gastrointestinal tract, which manifest in recurring gastrointestinal inflammation. The current treatment options of IBD are not curative and are lacking in aspects like prevention of fibrosis. New treatment options are needed to fulfil the unmet needs and provide alternatives to drugs with resistances and side effects. Drugs targeting the renin-angiotensin system (RAS), besides being antihypertensive, also possess anti-inflammatory and antifibrotic properties and could offer an inexpensive alternative to control inflammation and fibrosis in the gut. RAS inhibitors have been effective in preventing and alleviating colitis in preclinical studies, but available human data are still sparse. This review outlines the pathophysiological functions of RAS in the gut and summarizes preclinical studies utilizing pharmacological RAS inhibitors in the treatment of experimental colitis. We discuss the alterations in intestinal RAS and the available evidence of the benefits of RAS inhibitors for IBD patients. Retrospective studies comparing IBD patients using ACE inhibitors or angiotensin II receptor blockers have provided optimistic results regarding a milder disease course and fewer hospitalizations and corticosteroid use in patients using RAS inhibitors. Prospective studies are needed to evaluate the effectiveness of these promising medications in the treatment of IBD.
Capacitive Power Transfer based on Compensation Circuit for Class E Resonant Full-Wave Rectifier (2018)

This paper outlines, for the first time, the use of a class E resonant full-wave rectifier in a capacitive power transfer (CPT) system, working at megahertz (MHz) in the medium power range. In order to cancel the reactances introduced by the rectifier and coupling capacitors, equations to determine the required compensation inductors are derived based on circuit analysis. Measurements of input impedance, output power, and system's efficiency are presented and verified by simulations.
Simulation of Pulsatile Blood Flow With a Wall Step Transition (2008)

Implantable devices in direct contact with flowing blood, for example, coronary stents, continuous flow and pulsatile flow ventricular assist devices, prosthetic heart valves, catheters and cannulae are currently being used to treat many medical conditions. However, thromboembolism and the attendant risk for ischemic stroke remains an impediment for all these devices. A prudent approach to developing these devices in a cost effective manner should include optimization for thrombogenic performance before going into expensive preclinical and clinical trials.
Image De-Noising using Wavelet Transform and Various Filters (2012)

The process of removing noise from the original image is still a demanding problem for researchers. There have been several algorithms and each has its assumptions, merits, and demerits. The prime focus of this paper is related to the pre processing of an image before it can be used in applications. The pre processing is done by de-noising of images. In order to achieve these de-noising algorithms, filtering approach and wavelet based approach are used and performs their comparative study. Different noises such as Gaussian noise, salt and pepper noise, speckle noise are used. The filtering approach has been proved to be the best when the image is corrupted with salt and pepper noise. The wavelet based approach has been proved to be the best in de-noising images corrupted with Gaussian noise. A quantitative measure of comparison is provided by the parameters like Peak signal to noise ratio, Root mean square error and Correlation of the image..
Regulation of Biochemical Plant Growth Regulators at the U.S. Environmental Protection Agency (2002)

Plant growth regulators (PGRs) are often used in crop production for specific niche market needs. PGRs are frequently viewed as secondary business opportunities by the private sector, especially when compared to herbicide, insecticide, and/or fungicide markets. Nonetheless, PGRs are regulated by the U.S. Environmental Protection Agency (USEPA), and the additional cost of regulatory compliance as part of commercial development is significant. Of the two broad classes of pesticides regulated by the USEPA, conventional chemicals and biological pesticides (or biopesticides), many PGRs belong to the biopesticide class, specifically the biochemical category. Because of USEPA's responsibility to assure that any pesticide used in commerce will not result in unreasonable adverse effects to humans or the environment, specific data requirements have been established for product registration. Registrants must address each requirement, either by submitting relevant data or a request to waive the requirement, prior to receiving a federal registration. For biochemical PGRs, the acceptability of data or waiver requests, as well as any proposed label uses, are reviewed by the Biopesticides and Pollution Prevention Division (BPPD). The BPPD was formed in 1994 to facilitate the development of biopesticide products. Given the time and expense associated with PGR product development and commercialization, registrants should work closely with the USEPA and other stakeholders to help ensure successful product development.
Cervical Spine (2014)

Gastric volvulus is a serious, often fatal problem that occurs primarily in large, deep-chested dogs. Gastropexy,1,2 gastroplasty,3 tube gastrostomy,4 and gastrocolopexy5 have all been used in an attempt to fix the stomach to the body wall permanently and to prevent recurrent volvulus. The incisional gastropexy1 offers a method of producing a permanent gastropexy without the potential complications and aftercare associated with tube gastrostomy. It may be used as an alternative to a tube gastrostomy when postoperative decompression will be provided by pharyngostomy tube or is not thought necessary, but a permanent gastropexy is still desired.6 The same low potential for complications also makes it suitable as a prophylactic procedure in high-risk patients.
Calculations of metallic conduction in hydrogen (1985)

This study were estimated the contribution of carcass traits to unit price, to analyze the marbling score as a categorical variable rather than a numerical variable, and to develop an optimal model that also includes the holiday effect and the raising period. The data for this study were acquired from the Quality Evaluation of the Korea Institute for Animal Products, and consisted of the trading records of 1,613,699 heads at 12 wholesale markets from 2010 to 2014. The unit price of a cow was estimated from the following parameters: -52.50 Won/mm, 8.93 Won/cm<sup>2</sup>, 7.20 Won/kg, and -1.04 Won/day for backfat thickness, eye muscle area, carcass weight, and raising period, respectively. Parameters for the dummy variables of marbling scores varied from 0 to 8328.74 Won/kg, which means that each marbling score grade had a different price value. The unit price of a steer was estimated from the following parameters: -92.12 Won/mm, 20.22 Won/cm<sup>2</sup>, 1.30 Won/kg, and -1.72 Won/day for backfat thickness, eye muscle area, carcass weights, and raising period, respectively. Parameters for dummy variables of marbling scores varied from 0 to 7338.80 Won/kg, which means that the grades of each marbling score had different price values. The unit price of sales during traditional holidays was significantly higher (827.71 Won/kg for cows, and 645.15 Won/kg for steers) than during non-holidays.We conclude that the use of categorical values for marbling scores would be needed to evaluate the price of Hanwoo beef using multiple regression analysis based on carcass traits and environmental factors.
The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1 (2019)

Obesity is taking on worldwide epidemic proportions, yet effective pharmacological agents with long-term efficacy remain unavailable. Previously, we designed the iminosugar N-adamantine-methyloxypentyl-deoxynojirimycin (AMP-DNM), which potently improves glucose homeostasis by lowering excessive glycosphingolipids. Here we show that AMP-DNM promotes satiety and activates brown adipose tissue (BAT) in obese rodents. Moreover, we demonstrate that the mechanism mediating these favorable actions depends on oral, but not central, administration of AMP-DNM, which ultimately stimulates systemic glucagon-like peptide 1 (GLP1) secretion. We evidence an essential role of brain GLP1 receptors (GLP1r), as AMP-DNM fails to promote satiety and activate BAT in mice lacking the brain GLP1r as well as in mice treated intracerebroventricularly with GLP1r antagonist exendin-9. In conclusion, AMP-DNM markedly ameliorates metabolic abnormalities in obese rodents by restoring satiety and activating BAT through central GLP1r, while improving glucose homeostasis by mechanisms independent of central GLP1r.
Smart photonic materials for theranostic applications (2017)

We developed melanoidin nanoparticles for <i>in vivo</i> noninvasive photoacoustic mapping of sentinel lymph nodes, photoacoustic tomography of gastro-intestinal tracts, and photothermal ablation cancer therapy. In addition, we developed cell-integrated poly(ethylene glycol) hydrogels for <i>in vivo</i> optogenetic sensing and therapy. Real-time optical readout of encapsulated heat-shock-protein-coupled fluorescent reporter cells made it possible to measure the nanotoxicity of cadmium-based quantum dots <i>in vivo</i>. Using optogenetic cells producing glucagon-like peptide-1, we performed lightcontrolled diabetic therapy for glucose homeostasis. Finally, we developed a smart contact lens composed of biosensors, drug delivery systems, and power sources for the treatment of diabetes as a model disease.
Photoyellowing behavior of non-phenolic lignin models representative of end groups and β-ether structures (2004)

Lignin model compounds representative of etherified end groups [(E)-3-(3,4-dimethoxyphenyl)-2-propenl-ol (1), (E)-3-(3,4-dimethoxyphenyl) propenal (2)] and βethers, [1-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-methoxy- phenoxy)-1-propanone (3), erythiro-1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)- 1,3-propanediol (4)] have been applied to filter paper and subjected to accelerated photoaging with UV/VIS-light. The changes in optical properties were monitored. In case of all the models, the brightness decreased and the b*-value increased as a result of irradiation, which shows that they are sensitive to light simulating sunlight behind window-glass. In the case of the end group models, the photo-products identified were veratraldehyde and veratric acid together with the Z-isomers of the starting materials. In the case of the cinnamyl alcohol 1, photo-oxidation to the cinnamaldehyde 2 was observed. The irradiation of the αt-carbonylic βether 3 resulted in the homolytic cleavage of the CβO bond and a recombination that led to a β-5 dimer [1-(3,4-dimethoxyphenyl)-3-hydroxy-2-(2-hydroxy-3-methoxyphenyl)- 1-propanone] and a β-1 dimer [1-(3,4-dimethoxyphenyl)-3-hydroxy-2-(4- hydroxy-3-methoxyphenyl)-l-propanone]. The monomeric products veratraldehyde, vanillin, acetoveratrone, and 1-(3,4-dimethoxyphenyl)-3-hydroxy-l-propanone were also formed. The only photoproduct conclusively identified in experiments with the arylglycerol-β-aryl ether 4 was veratraldehyde and most of the starting material was unaffected by the irradiation. The addition of a photosensitizer (acetoveratrone) to this type of model prior to irradiation resulted in some increase in discoloration.