gebhart/patrepeval huggingface dataset:
Introduction of Proteomic Approach to Environmental Medicine (2006)

Recent progress in life science technology and the availability of much information on genes obtained by genome analysis has enabled us to analyze the changes of proteins on a large scale. Sets of proteins are called proteomes, and proteomics is the scientific field of proteome analysis including differential, post translational modification and interaction analyses. Various proteomic techniques, particularly two-dimensional gel electrophoresis (2-DE), mass spectrometry, protein chip methods, and surface plasmon resonance (SPR), are very useful for acquiring proteomes in cells, tissues and body fluid, and for analyzing interactions between a protein and other biofactors including proteins. A proteomic approach is also useful for determining biomarkers of diseases and key proteins involved in various stages of metabolism such as differentiation, cell cycle and apoptosis. Environmental pollutants including endocrine disruptors inhibit activities of various organs in wild animals and humans. Proteomic approaches could be very useful tools for elucidating the mechanisms of damage caused by environmental pollutants. In this review, we describe the application of a proteomic approach to the field of environmental medicine.
Ras Labs.-CASIS-ISS NL experiment for synthetic muscle: resistance to ionizing radiation (2016)

In anticipation of deep space travel, new materials are being explored to assist and relieve humans in dangerous environments, such as high radiation, extreme temperature, and extreme pressure. Ras Labs Synthetic Muscle – electroactive polymers (EAPs) that contract and expand at low voltages – which mimic the unique gentle-yet-strong nature of human tissue, is a potential asset to manned space travel through protective gear and human assist robotics and for unmanned space exploration through deep space. Generation 3 Synthetic Muscle was proven to be resistant to extreme temperatures, and there were indications that these materials may also be radiation resistant. The purpose of the Ras Labs-CASIS-ISS Experiment is to test the radiation resistivity of the third and fourth generation of these EAPs, as well as to make them even more radiation resistant or radiation hardened. On Earth, exposure of the Generation 3 and Generation 4 EAPs to a Cs-137 radiation source for 47.8 hours with a total dose of 305.931 kRad of gamma radiation was performed at the US Department of Energy’s Princeton Plasma Physics Laboratory (PPPL) at Princeton University, followed by pH, peroxide, Shore Hardness Durometry, and electroactivity testing to determine the inherent radiation resistivity of these contractile EAPs and to determine whether the EAPs could be made even more radiation resistant through the application of appropriate additives and coatings. The on Earth preliminary tests determined that selected Ras Labs EAPs were not only inherently radiation resistant, but with the appropriate coatings and additives, could be made even more radiation resistant. Gforce testing to over 10 G’s was performed at US Army’s ARDEC Labs, with excellent results, in preparation for space flight to the International Space Station National Laboratory (ISS-NL). Selected samples of Generation 3 and Generation 4 Synthetic Muscle™, with various additives and coatings, were launched to the ISS-NL on April, 14 2015 on the SpaceX-6 payload, and will return to Earth in 2016. The most significant change from the on Earth radiation exposure was color change in the irradiated EAP samples, which in polymers can be indicative of accelerated aging. There was visible yellowing in the irradiated samples compared to the control samples, which were not irradiated and were clear and colorless. While the Synthetic Muscle Experiment is in orbit on the ISS-NL, photo events occur every 4 to 6 weeks to observe any changes, such as color, in the samples. The bulk of the testing will occur when these EAP samples return back to Earth, and will be compared to the duplicate experiment that remains on Earth (the control experiment). Smart electroactive polymer based materials and actuators promise to transform prostheses and robots, allowing for the treatment, reduction, and prevention of debilitating injury and fatalities, and to further our exploration by land, sea, air, and space.
Sonochemical and Microwave-Assisted Preparations of PbTe and PbSe. A Comparative Study (2001)

Sonochemical and microwave-assisted polyol reduction methods were used to prepare PbSe and PbTe. Products prepared by both methods were compared and analyzed by XRD, EDX, TEM, HR-TEM, elemental analysis, FT-IR, and thermal methods (DSC and TGA). In both methods almost pure lead chalcogenide phases were prepared, which were almost free of carbon (<0.08%), but the morphology of the resultant nanoparticles was entirely different. The mechanism of formation for the lead chalcogenide nanoparticles for both microwave and sonochemical reactions is discussed.
Formyl Peptide Receptor 2 Plays a Deleterious Role During Influenza A Virus Infections (2016)

These data show that viral replication and IAV pathogenesis depend on FPR2 signaling and suggest that FPR2 may be a promising novel strategy to treat influenza.
MLN3897, a Novel CCR1 Antagonist, Inhibits Osteoclastogenesis by Blocking Early ERK Activation. (2006)

Abstract Osteolytic lesions are a hallmark of myeloma bone disease and other metastatic cancers, resulting in significant morbidity. In order to successfully target skeletal disease, it is critical to identify the mediators of osteoclastogenesis. Osteoclastogenesis is a multistep process regulated by receptor activator of nuclear factor κ B ligand (RANKL) and monocyte colony stimulating factor (mCSF). These cytokines recruit monocyte precursors, stimulate their fusion into multinucleated cells, and finally induce osteoclast (OC) formation and activation. Recent data suggest that several chemokines in combination with RANKL and/or vitamin D3 (Oba et al., Exp. Hematology 2005) modulate osteoclastogenesis. Moreover, the autocrine secretion of RANTES and MCP-1 mediate monocyte multinucleation (Kim et al., J. Biol. Chem. 2005), the initial step towards osteoclastogenesis. Since CCR1 is one of the main chemokine receptors expressed on monocytes and OC, we here studied the effects of CCR1 inhibition on osteoclastogenesis. MLN3897 is a small molecule, specific antagonist of the chemokine receptor CCR1. In order to analyze the effects of MLN3897 on osteoclastogenesis, we generated OC from peripheral blood mononuclear cells (PBMC) from healthy donors by stimulation with RANKL and M-CSF (50 ng/ml) for three weeks, in the absence or presence of MLN3897. Mature OC were multinucleated TRAP+ cells, and their functional activity was confirmed by a pit formation and a collagen release ELISA assay. Our data demonstrates that MLN3897 inhibits osteoclastogenesis in a dose and time-dependent fashion. MLN3897 at 10 nM concentration decreases OC number to 40% (range 20 to 70%) compared to untreated controls (p&lt;0.05). Time course experiments demonstrate that MLN3897 inhibites OC formation if added at the beginning of culture, whereas no inhibition is noted after 7 or 14 days. The reduced OC number is associated with decreased OC activity as demonstrated by a decrease in collagen fragments (control 82 +/−8 vs treated 25+/− 19 nM). Because the effects of MLN3897 are noted at early time points, we hypothesized that MLN3897 interfers with the monocyte multinucleation process. Our data demonstrates that MLN3897 induces a 60% reduction in the multinucleated cell number at one week (control 61+/−14 vs treated 35+/−9), associated with decreased nuclei per cell at two weeks. This correlates with an early induction of CCR1 expression on monocytes by RANKL and mCSF. Flow cytometry confirms an increment of double-stained CD14/CCR1 monocyte population (from 20% to 50%) associated with increased ERK phosphorylation at 36 hours of stimulation, which is completely abrogated by MLN3897. Taken together, these data therefore suggest that CCR1 inhibition by MLN3897 blocks ERK pathway activation and impairs the monocyte multinucleation process, an early step in osteoclastogenesis. These studies delineate a novel mechanism of action of MLN3897 on osteoclastogenesis, and provide the rationale for its clinical evaluation to treat osteolytic bone disease.
Direct Path Interference Suppression Requirements for Bistatic Backscatter Communication System (2021)

The ambient backscatter communication (AmBC) system utilizes the existing ambient RF signals present in the atmosphere for backscattering the signal. One of the challenges for AmBC system is the interference at the receiver module caused by the direct path signal from the ambient source. The purpose of this paper is to study the coverage aspects of the bi-static backscatter communication system in a typical urban environment at sub-1GHz frequencies using simulations in MATLAB. For the simulation, 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> generation partnership project (3GPP) urban microcellular and international telecommunication union (ITU) device-to-device (D2D) propagation models are used. Moreover, the dynamic range i.e., the difference in the received power level of the direct path and the backscatter path is investigated. For correctly decoding the backscatter signal at the reader, the target value set for the dynamic range is less than 30 dB. This paper studies the importance of direct path interference suppression for the successful deployment of a bi-static backscatter communication system.
Supplementary Movie 1 from Coordinated Regulation of Pathways for Enhanced Cell Motility and Chemotaxis Is Conserved in Rat and Mouse Mammary Tumors (2023)

Supplementary Movie 1 from Coordinated Regulation of Pathways for Enhanced Cell Motility and Chemotaxis Is Conserved in Rat and Mouse Mammary Tumors
Investigating the rollover propensity of a 15 seater mini bus (2007)

In the present paper a full vehicle model of the Rural Transport Vehicle (RTV) is developed in MADYMO. The steering, tyre and suspension are modelled using standard modules available in the package. A speed controller was also designed using the package to maintain a constant speed of the RTV in simulations. Validation of the model was against experimental accelerations measured over bumps. The validated model is used to predict rollover characteristics using Slowly Increasing Steer (SIS), J-turn and Road Edge Recovery (RER) manoeuvres. These manoeuvres were conducted for three different loading conditions viz. RTV without passengers, RTV with unrestrained passengers and RTV with restrained passengers.
Intestinal starch and energy digestibility in broiler chickens fed diets supplemented with α-amylase (2020)

Dietary starch is the major energy source for broiler chickens; therefore, relevant information on its intestinal utilization is important. The present study was designed to evaluate intestinal starch and energy digestibility of broiler chickens fed diets supplemented with α-amylase. A total of 240 day-0 male broiler chicks were randomly assigned to 3 nutritionally adequate corn-soybean-based experimental diets comprising 3 levels of α-amylase supplementation (0, 80, or 160 KNU/kg diet). Each treatment comprised 8 replicate cages of 10 birds each. At day 21 after hatching, digesta was collected from 4 intestinal sites: the anterior jejunum (AJ), posterior jejunum (PJ), anterior ileum (AI), and posterior ileum. Increasing α-amylase supplementation linearly improved (P < 0.01) overall BW gain and feed efficiency of the birds. There were linear and quadratic (P < 0.01) responses of increasing α-amylase supplementation on starch and energy digestibility at the PJ and AI. The total tract digestibility of starch increased (P < 0.05) with increasing α-amylase supplementation. Starch disappearance and digestible energy (kcal/kg) linearly increased (P < 0.01) with digesta flow from the AJ to PJ as dietary α-amylase supplementation increased. There were linear (P < 0.01) and quadratic (P < 0.05) effects of increasing α-amylase supplementation on the villus height in the jejunum. The viscosity of the jejunal digesta decreased (P < 0.05) with increasing dietary α-amylase supplementation. The results from this study showed the efficacy of exogenous amylase in improving growth performance and starch and energy digestibility in broiler chickens. Furthermore, the digestibility of starch and energy and the impact of the exogenous amylase were higher at the PJ than other intestinal sites.
Genome scan in familial late‐onset Alzheimer's disease: A locus on chromosome 6 contributes to age‐at‐onset (2013)

Alzheimer's disease (AD) is a common, genetically complex, fatal neurodegenerative disorder of late life. Although several genes are known to play a role in early-onset AD, identification of the genetic basis of late onset AD (LOAD) has been challenging, with only the APOE gene known to have a high contribution to both AD risk and age-at-onset. Here, we present the first genome-scan analysis of the complete, well-characterized University of Washington LOAD sample of 119 pedigrees, using age-at-onset as the trait of interest. The analysis approach used allows for a multilocus trait model while at the same time accommodating age censoring, effects of APOE as a known genetic covariate, and full pedigree and marker information. The results provide strong evidence for linkage of loci contributing to age-at-onset to genomic regions on chromosome 6q16.3, and to 19q13.42 in the region of the APOE locus. There was evidence for interaction between APOE and the locus on chromosome 6q and suggestive evidence for linkage to chromosomes 11p13, 15q12-14, and 19p13.12. These results provide the first independent confirmation of an AD age-at-onset locus on chromosome 6 and suggest that further efforts towards identifying the underlying causal locus or loci are warranted.
Myxol and 4-Ketomyxol 2′-Fucosides, not Rhamnosides, from Anabaena sp. PCC 7120 and Nostoc punctiforme PCC 73102, and Proposal for the Biosynthetic Pathway of Carotenoids (2005)

We identified the molecular structures of carotenoids in some Anabaena and Nostoc species. The myxoxanthophyll and ketomyxoxanthophyll in Anabaena (also known as Nostoc) sp. PCC 7120, Anabaena variabilis IAM M-3, Nostoc punctiforme PCC 73102 and Nostoc sp. HK-01 were (3R,2'S)-myxol 2'-fucoside and (3S,2'S)-4-ketomyxol 2'-fucoside, respectively. The glycoside moiety of the pigments was fucose, not rhamnose. The major carotenoids were beta-carotene and echinenone, and the minor ones were beta-cryptoxanthin, zeaxanthin, canthaxanthin and 3'-hydroxyechinenone. Based on the identification of the carotenoids and the completion of the entire nucleotide sequence of the genome in Anabaena sp. PCC 7120 and N. punctiforme PCC 73102, we proposed a biosynthetic pathway for the carotenoids and the corresponding genes and enzymes. Since only zeta-carotene desaturase (CrtQ) from Anabaena sp. PCC 7120 and beta-carotene ketolase (CrtW) from N. punctiforme PCC 73102 have been functionally identified, the other genes were searched by sequence homology only from the functionally confirmed genes. Finally, we investigated the phylogenetic relationships among some Anabaena and Nostoc species, including some newly isolated species.
Corrosion Behavior of Transmission Pipeline Steels in Dense-Phase Carbon Dioxide (2022)

Abstract Pipeline transportation systems are the most cost-effective method to transport liquid or supercritical CO2 from points of capture to sites where it will be permanently stored or used for industrial purposes. Many factors complicate designing an efficient CO2 transmission pipeline and selecting materials. These factors include gas chemistry and impurities (O2, H2O, H2S), pressure, and velocity. The presence of impurities in supercritical CO2 can promote steel corrosion. The objective of this study was to investigate the corrosion behavior of three pipeline steels (X56, X65, and X100) exposed to dense-phase CO2 at 100 bar CO2 partial pressure and 30°C. The corrosion performance of each steel was evaluated in a CO2 saturated water phase and dense-phase CO2 utilizing an immersion autoclave. The weight loss method was used to investigate the corrosion performance of the pipeline steels in dense-phase CO2. Post-corrosion surface characterization was performed by scanning electron microscopy equipped with energy dispersive X-ray spectroscopy. The data obtained show that each steel’s corrosion degradation is more dominant in the CO2 saturated water phase compared to dense-phase CO2.
Heart Failure Pathogenesis Elucidation and New Treatment Method Development (2022)

Heart failure (HF) is a leading cause of death worldwide. In Japan, the number of HF patients has increased with its aging population, resulting in "HF pandemic." HF is the final stage of various cardiovascular diseases, including valvular heart disease, ischemic heart disease, atrial fibrillation, and hypertension. Cardiac hypertrophy is a compensatory response to increased workload and maintains cardiac function. Pressure overload due to mechanical stress causes cardiac hypertrophy, whereas continuous cardiac stress reduces wall thickness and consequently causes HF. Understanding the molecular mechanisms underlying this process is crucial to elucidate HF pathophysiology. We demonstrated that ischemia and DNA damage are important in the progression of hypertrophy to HF. Genetic mutations associated with cardiomyopathy and prognosis has been identified. To realize precision medicines for HF, the underlying molecular mechanisms need to be elucidated. In this review, we introduce new paradigms for understanding HF pathophysiology discovered through basic research.
BEEKES, ROBERT with the assistance of LUCIEN VAN BEEK: Etymological Dictionary of Greek. (2013)

Anläßlich von: Beekes, Robert with the assistance of Lucien van Beek: Etymological Dictionary of Greek. Leiden Indo-European Etymological Dictionary Series, 10. Brill Verlag Leiden, 2009. 2 Bände, xlviii, 1808 Seiten. Gebunden, 419,00 EUR. ISBN: 978-90-04-17418-4.
Reduced Graphene Oxides Modified Bi<sub>2</sub>Te<sub>3</sub> Nanosheets for Rapid Photo‐Thermoelectric Catalytic Therapy of Bacteria‐Infected Wounds (2022)

Abstract Temperature variation‐induced thermoelectric catalytic efficiency of thermoelectric material is simultaneously restricted by its electrical conductivity, Seebeck coefficient, and thermal conductivity. Herein, Bi 2 Te 3 nanosheets are in situ grown on reduced graphene oxides (rGO) to generate an efficient photo‐thermoelectric catalyst (rGO‐Bi 2 Te 3 ). This system exhibits phonon scattering effect and extra carrier transport channels induced by the formed heterointerface between rGO and Bi 2 Te 3 , which improves the power factor value and reduces thermal conductivity, thus enhancing the thermoelectric performance of 2.13 times than single Bi 2 Te 3 . The photo‐thermoelectric catalysis of rGO‐Bi 2 Te 3 significantly improves the reactive oxygen species yields, resulting from the effective electron–hole separation caused by the unique thermoelectric field and heterointerfaces of rGO‐Bi 2 Te 3 . Correspondingly, the electrospinning membranes containing rGO‐Bi 2 Te 3 nanosheets exhibit high antibacterial efficiency in vivo (99.35 ± 0.29%), accelerated tissue repair ability, and excellent biosafety. This study provides an insight into heterointerface design in photo‐thermoelectric catalysis.
The changing landscape of biofuels (2017)

This chapter provides a global overview of the geography of major biofuel feedstock landscapes, and focuses on landscape change, several conflicts and their resolutions. It also provides a world regional review of biofuel landscapes, with attention to crop choice and characteristics, industrial location, and whether the biorefineries are export oriented or focused on meeting domestic fuel demand. The chapter discusses several case studies of conflicts associated with biofuel development, such as feedstock selection, environmental issues and sustainability. These energy landscape issues are socioeconomic as well as environmental, and have been concentrated in Latin America and Southeast Asia. Biofuel production in Southeast Asia is dominated by biodiesel from oil palm plantations in Indonesia, with major landscape change, and to a lesser extent Thailand and Malaysia. The growth in biofuel production and consumption has been driven by government policies intent on increasing the use of biofuels to combat climate change, increase rural development and foster energy security.
Innovations in Synthetic Carbohydrate Chemistry—Practical and Conceptual Approaches to Glycoside Synthesis (1977)

The continued discovery of new antibiotics and of other, biologically important substances, containing glycosidically-linked sugars, has provided much impetus to the problems associated with glycoside synthesis (1). With the advent of sophisticated methodology, it has been possible to probe the biological effects of these substances at the molecular level, and to gain better insight into their respective roles. It is now clear that biological specificities are dependent not only on the nature of the sugars present in the substrate, but also on the type of glycosidic linkages that are involved. This feature is in turn, closely related to the molecular shape in solution, and to preferred rotamer populations of the aglycon and the oxygen atom involved in the glycosidic linkage (2). The functional, stereochemical, conformational and spatial characteristics of carbohydrates are therefore of utmost significance within a particular biological environment. The primordial importance of many carbohydrate biopolymers in life processes
Geological Consistency from Inversions of Geophysical Data (2017)

Summary A subsurface volume that can be reliably interpreted in terms of geologically relevant parameters is a desirable outcome from depth inversion workflows. Geophysical data are often inaccurate and incomplete, the inverse problem is commonly non-unique, and constraints are usually required to recover useful output models. We introduce a novel application of the established cross-gradient operator to incorporate surface or subsurface geological and other attribute measurements in a data-driven workflow, delivering a model consistent with all the available information. Two field data examples are presented: in the first we constrain an airborne electromagnetic inversion with surface geology observations (dip and strike); secondly we employ a seismic volume to constrain a marine controlled-source electromagnetic inversion, where a structure tensor operator is used to derive the directional information.
Electro-thermal stress and high electric field effects in CVD-Grown 4H-SiC P-N junction diodes (1996)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Chin‐Che Tin, Rongxiang Hu, Manfred Lang, Tamara Isaacs‐Smith, Vipin Madangarli, George Gradinaru, Tangali Sudarshan, David Sheridan, Jeffrey Casady; Electro‐thermal stress and high electric field effects in CVD‐Grown 4H‐SiC P‐N junction diodes. AIP Conf. Proc. 1 March 1996; 361 (1): 225–230. https://doi.org/10.1063/1.50009 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Revisión y Control del Plan de Vigilancia Ambiental de las obras de dragado del Puerto de Maó (2014)

Se integra información hidrográfica, geomorfológica, sedimentológica y biológica, para la caracterización de los ecosistemas marinos en el punto de vertido y área adyacente previa al inicio de las obras de dragado del Puerto de Maó.