gebhart/patrepeval huggingface dataset:
1,25-Dihydroxyvitamin D3 and Its Analog TX527 Promote a Stable Regulatory T Cell Phenotype in T Cells from Type 1 Diabetes Patients (2014)

The emergence of regulatory T cells (Tregs) as central mediators of peripheral tolerance in the immune system has led to an important area of clinical investigation to target these cells for the treatment of autoimmune diseases such as type 1 diabetes. We have demonstrated earlier that in vitro treatment of T cells from healthy individuals with TX527, a low-calcemic analog of bioactive vitamin D, can promote a CD4+ CD25high CD127low regulatory profile and imprint a migratory signature specific for homing to sites of inflammation. Towards clinical application of vitamin D-induced Tregs in autologous adoptive immunotherapy for type 1 diabetes, we show here that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and TX527 similarly imprint T cells from type 1 diabetes patients with a CD4+ CD25high CD127low regulatory profile, modulate surface expression of skin- and inflammation-homing receptors, and increase expression of CTLA-4 and OX-40. Also, 1,25(OH)2D3 and TX527 treatment inhibit the production of effector cytokines IFN-γ, IL-9, and IL-17. Importantly, 1,25(OH)2D3 and TX527 promote the induction of IL-10-producing CD4+ CD25high CD127low T cells with a stable phenotype and the functional capacity to suppress proliferation of autologous responder T cells in vitro. These findings warrant additional validation of vitamin D-induced Tregs in view of future autologous adoptive immunotherapy in type 1 diabetes.
[Occupational transmission by HIV and by hepatitis B virus. Attitude of Belgian surgeons and anesthetists. An opinion survey]. (1992)

Risk of professional transmission of hepatitis B is known since the seventies. Recently the possibility of HIV transmission during surgical practice was demonstrated. It was interesting to assess Belgian surgeons and anesthetists opinion about this risk and about the precautions taken. An opinion survey was performed with a representative sample of Belgian surgeons and orthopedists (340) as well as anesthetists (100). Risks of transmission of HIV and possible elementary precautions are not well known. The rate of vaccination against hepatitis B is low, specially in smaller hospitals. However the frequency of injuries during practice is high in surgeons as well as in anesthetists. This study shows that important information efforts about the risks of HIV infection and the possible precautions to be taken are still necessary. Information about the need for vaccination against hepatitis B should also be done, considering the high incidence of operative injuries.
An online quality monitoring tool for information acquisition and sharing in manufacturing: requirements and solutions for the steel industry (2019)

The purpose of this study was to develop an innovative online supervisor system to assist the operators of an industrial manufacturing process in discovering new solutions for improving both the products and the manufacturing process itself. In this paper, we discuss the requirements and practical aspects of building such a system and demonstrate its use and functioning with different types of statistical modelling methods applied for quality monitoring in industrial applications. The two case studies presenting the development work were selected from the steel industry. One case study predicting the profile of a stainless steel strip tested the usability of the tool offline, while the other study predicting the risk of roughness of a steel strip had an online test period. User experiences from a test use period were collected with a system usability scale questionnaire.
Randomized Phase II Neoadjuvant Comparison Between Letrozole, Anastrozole, and Exemestane for Postmenopausal Women With Estrogen Receptor–Rich Stage 2 to 3 Breast Cancer: Clinical and Biomarker Outcomes and Predictive Value of the Baseline PAM50-Based Intrinsic Subtype—ACOSOG Z1031 (2011)

Neoadjuvant AI treatment markedly improved surgical outcomes. Ki67 and PEPI data demonstrated that the three agents tested are biologically equivalent and therefore likely to have similar adjuvant activities. LumA tumors were more likely to have favorable biomarker characteristics after treatment; however, occasional paradoxical increases in Ki67 (12% of tumors with > 5% increase after therapy) suggest treatment-resistant cells, present in some LumA tumors, can be detected by post-treatment profiling.
2D Optical Phased Arrays for Laser Beam Steering Based on 3D Polymer Photonic Integrated Circuits (2021)

We propose a novel concept for the implementation of 2-dimensional (2D) optical phased arrays (OPAs) with end-fire waveguides as antenna elements (AEs), and we present its theoretical model and experimental proof. The concept is based on the use of 3-dimensional (3D) photonic integrated circuits (PICs) with multiple waveguiding layers on the PolyBoard platform. In their simplest form, the 3D PICs comprise AEs at different layers, vertical and lateral couplers for the distribution of light among the AEs, and phase shifters for the execution of the 2D beam scanning process. Using the field equivalence principle, we model the radiated field from the single-mode waveguide of the platform at 1550 nm, and we find that the expected beam width is 12.7&lt;sup&gt;o&lt;/sup&gt;. We also investigate the perturbation that is induced into propagating fields inside parallel waveguides in proximity, and we conclude that waveguide spacings down to 6 µm can be safely used for development of uniform OPAs in the PolyBoard platform. For OPAs with 6 µm pitch and 4 AEs, we find that the maximum steering angle is 14.0&lt;sup&gt;o&lt;/sup&gt; and the expected angular clearance, wherein the main radiation lobe is higher than any grating lobe by at least 3, 6 and 10 dB is 10.8&lt;sup&gt;o&lt;/sup&gt;, 7.6&lt;sup&gt;o&lt;/sup&gt; and 2.8&lt;sup&gt;o&lt;/sup&gt;, respectively. Based on our simulations, we design and fabricate single- and 2-layer PICs with 1×4 and 2×4 OPAs. The lateral pitch of the OPAs ranges from 10 down to 6 µm, while the vertical pitch is 7.2 µm. We experimentally characterize these OPAs and validate the potential of the 2-layer PICs for 2D beam scanning on the azimuthal and elevation plane. The beam profiles and the main scanning parameters such as the maximum steering angle and the relative intensity between the main and the grating lobes are found in excellent agreement with our simulations.
Proinflammatory cytokines and type I interferon are differentially induced by virulent and avirulent mycobacteria in human macrophages (37.36) (2010)

Abstract One third of the world’s population is latently infected with Mycobacterium tuberculosis (MTB), a virulent intracellular pathogen that can survive in macrophages even in the presence of a strong adaptive immune response. The molecular mechanisms underlying MTB persistence are not fully understood. Production of type I interferon (IFN) has been linked to the exacerbation of pulmonary tuberculosis (TB) in mice. However, the role of type I IFN in human TB is as yet undefined. In this study, primary macrophages derived from elutriated monocytes of healthy individuals were infected with MTB or M. bovis Bacillus Calmette-Guérin (BCG), an attenuated vaccine strain, and their responses analyzed by qPCR. We observed that compared to BCG, MTB infection induced markedly lower expression of the NF-kB-dependent pro-inflammatory cytokine genes IL-1 and IL-8 at all time-points examined. On the other hand, transcript levels of the type I IFN associated genes CXCL10 and IFIT1 were significantly higher in MTB infected compared to BCG-infected macrophages. These findings suggest that the differential regulation of type I IFN is a determinant of mycobacterial virulence in human macrophages and that MTB may exploit the host type I IFN pathway to subvert anti-microbial programs in these host cells. This work was supported by the Intramural Research Program of the NIAID and by the Howard Hughes Medical Institute-National Institutes of Health Research Scholars Program.
THE FREQUENCY OF C4B VARIANTS OF COMPLEMENT IN FAMILIAL AND SPORADIC ALZHEIMER DISEASE (1987)

A previous study reported an unexpected increased frequency of the uncommon C4B2 allele of complement in a group of patients with senile dementia of the Alzheimer type. We compared the frequency of various C4B types in 25 patients with familial Alzheimer dementia (AD), 22 patients with sporadic AD, and 360 control individuals. Neither Alzheimer group showed any significant increase or decrease in the frequency of C4B alleles compared with controls. We were unable to confirm any association between AD and the C4B2 allele.
Factor VIIa-antithrombin complexes in patients with arterial and venous thrombosis (2010)

Antithrombin (AT), in the presence of heparin, is able to inhibit the catalytic activity of factor VIIa bound to tissue factor (TF) on cell surfaces. The clinical meaning of FVIIa-AT complexes plasma levels is unknown. It was the objective of this study to evaluate FVIIa-AT complexes in subjects with thrombosis. Factor VIIa-AT complexes plasma levels in 154 patients consecutively referred to our Department with arterial or venous thrombosis and in a group of 154 healthy subjects, were measured. Moreover, FVIIa-AT complexes were determined in: i) n = 53 subjects belonging to 10 families with inherited factor VII deficiency; ii) n = 58 subjects belonging to seven families with AT deficiency; iii) n = 49 patients undergoing oral anticoagulant therapy (OAT). Factor VIIa-AT levels were determined by a specific ELISA kit (R&D, Diagnostica Stago, Gennevilliers, France). Factor VIIa-AT complexes mean plasma levels were lower in patients with either acute arterial (136 +/- 40 pM) or venous (142 +/- 53 pM) thrombosis than subjects with previous thrombosis (arterial 164 +/- 33 pM and venous 172 +/- 61 pM, respectively) and than healthy controls (156 +/- 63 pM). Differences between acute and previous thrombosis, were statistically significant (p < 0.05). Subjects with inherited and acquired (under OAT) factor VII deficiency had statistically significant lower FVIIa-AT complexes plasma levels (80 +/- 23 pM and 55 +/- 22 pM, respectively) than controls (150 +/- 51 pM, p < 0.0001 and 156 +/- 63 pM, p < 0.00001, respectively). Factor VIIa-AT complexes are positively correlated with plasma factor VII/VIIa levels. Further investigations are needed to verify the possible role of higher FVIIa-AT complex plasma levels in predicting hypercoagulable states and thrombosis.
Evaluation of Osteochondral Allograft Transplant Using In‐Office Needle Arthroscopy (2022)

In-office needle arthroscopy (IONA) has been available in various iterations for decades. Studies have described it as comparable if not superior to magnetic resonance imaging for identifying intra-articular pathology with associated cost savings per patient. A new IONA system has been brought to market with a modernized user interface and disposable handpieces offering the opportunity to address intra-articular pathology. This article outlines the use of this IONA system for the postoperative evaluation of an osteochondral allograft transplant.
Enantiosensitive Lasermassenspektrometrie chiraler Moleküle (2007)

Im Rahmen der vorliegenden Arbeit wurden die Grundlagen geschaffen, um die Chiralitat optisch aktiver Verbindungen in einem Lasermassenspektrometer untersuchen zu konnen. Wahrend dies zuvor nur mithilfe indirekter Methoden moglich war, ist es nun gelungen, eine direkte massenselektive Methode zu entwickeln, die den Circulardichroismus (CD) einer optisch aktiven Substanz ausnutzt. Damit ist die schnelle, simultane Bestimmung von Molekulmasse und Enantiomerenuberschuss (ee) moglich. Neben der Entwicklung dieser neuen Methode wurden die beteiligten spektroskopischen Ubergange naher untersucht und charakterisiert. Abschliesend wurden verschiedene Wege erprobt, die Ionenstatistik zu verbessern, um auch kleine CD-Effekte erfassen zu konnen. Vielversprechende Ergebnisse konnten mittels Referenzstrahlexperimenten und durch Einsatz von Referenzsubstanzen erhalten werden.
Mutations in the heat-shock protein A9 (HSPA9) gene cause the EVEN-PLUS syndrome of congenital malformations and skeletal dysplasia (2015)

We and others have reported mutations in LONP1, a gene coding for a mitochondrial chaperone and protease, as the cause of the human CODAS (cerebral, ocular, dental, auricular and skeletal) syndrome (MIM 600373). Here, we delineate a similar but distinct condition that shares the epiphyseal, vertebral and ocular changes of CODAS but also included severe microtia, nasal hypoplasia, and other malformations, and for which we propose the name of EVEN-PLUS syndrome for epiphyseal, vertebral, ear, nose, plus associated findings. In three individuals from two families, no mutation in LONP1 was found; instead, we found biallelic mutations in HSPA9, the gene that codes for mHSP70/mortalin, another highly conserved mitochondrial chaperone protein essential in mitochondrial protein import, folding, and degradation. The functional relationship between LONP1 and HSPA9 in mitochondrial protein chaperoning and the overlapping phenotypes of CODAS and EVEN-PLUS delineate a family of "mitochondrial chaperonopathies" and point to an unexplored role of mitochondrial chaperones in human embryonic morphogenesis.
Data-based simultaneous design of plant model and robust filter in disturbance observer (2021)

Disturbance observer is a widely-used tool in the industrial field to reject the influence of disturbance and trial-and-error method is commonly employed in its design. This paper designed the plant model and low pass filter automatically in disturbance observer configuration by only using frequency response data. The design problem has been formulated into a convex optimization problem by mathematical calculation process. Finally, simulation and experiment results have verified the effectiveness of the proposal.
Influence of Polymerization Temperature on Molecular Weight, Photoluminescence, and Electroluminescence for a Phenyl-Substituted Poly(<i>p</i>-phenylenevinylene) (2001)

We present the synthesis and characterization of poly(2-(2‘ ‘,5‘-bis(2‘ ‘-ethylhexyloxy)phenyl)-1,4-phenylenevinylene) (BEHP-PPV) polymerized at different temperatures. The photoluminescence efficiencies in the solid state of BEHP-PPV obtained at 144 and 0 °C are 28% and 60%, respectively. 1H NMR measurements showed a lower concentration of structural defects for BEHP-PPV obtained at lower temperatures, which can explain the increased photoluminescence efficiencies for these polymers. Polymerization temperatures below 0 °C decrease the molecular weight without changing the photoluminescence efficiency to any large extent. The electroluminescence efficiencies follow the trend in the photoluminescence efficiencies.
A Method for the Analysis of a Large Number of Specific and Multispecific B Cell Hybridomas Derived from Primary Immunized Lymph Nodes (1987)

A previously described efficient short term immunization protocol enables analysis of the specificities of large numbers of monoclonal antibodies in murine lymph nodes. In this paper we measure the B cell responses against two highly immunogenic antigens, rat type II collagen (NRC) and chick ovalbumin (OVA), as well as against the poorly immunogenic denatured rat type II collagen (DRC). We found that relatively large numbers of specific B cell hybridomas could be produced after immunization with NRC (28%) and lower numbers with OVA (6%) and DRC (3%). However, in all immunizations there were also generated large numbers of hybridomas producing multispecific antibodies (5-15%). The multispecificity was sustained when the hybridomas were subcloned. These results show that large numbers of immunogen-reactive hybridomas can easily be obtained with the present method. They also show that different immunogens differ in their immunogenicity. The very high efficiency of native type II collagen to induce an antibody response, which is widely crossreactive with autologous type II collagen, could possibly be explained if it is assumed that the natural occurring repertoire is based on stimulation of autoantigens.
Beyond compression: a survey of functionality derived from still image coding (2004)

Research on wavelet image coding yielded the ISO/ITU JPEG 2000 standard. Although JPEG 2000 provides improved compression, the its great are progressive resolutions, bit-rate control (or quality control), and regions of interest. What does this suggest for the future of image coding? Should the old requirements (smaller files, faster transmission) be replaced? Perhaps it is time to view still image coding in the larger context of image communication considering such functionality such as access, enhancement, restoration, editing, understanding, security, indexing, and distribution. This paper surveys recent research with respect to these features and suggests future requirements for image coding systems.
A PGC‐1α:O‐GlcNAc Transferase Complex Regulates Foxo1a Activation in Response to Glucose (2008)

Paradoxically, hepatic gluconeogenesis is elevated in diabetes contributing to fasting hyperglycemia. Expression of the gluconeogenic enzymes, Pepck and Glc‐6‐Phosphatase is regulated by Foxo1a and the co‐activator Pgc‐1α. Insulin signaling results in nuclear exclusion of Foxo1a but post‐translational regulation within the nucleus also occurs. O‐GlcNAc modification of Ser/Thr residues serves as a nutrient and stress sensor. Foxo1a is GlcNAcylated, as shown by anti‐O‐GlcNAc antibodies, lectins and glycotransferase labeling. In rats, STZ‐induced diabetes increases UDP‐GlcNAc (donor for O‐GlcNAc), elevates GlcNAcylation of Foxo1a, and concomitantly increases Foxo1a target gene expression (Pepck and Glc‐6‐Pase). Hyperglycemia activates Foxo1a via the UDP‐GlcNAc synthesis pathway in a luciferase reporter assay. 4 O‐GlcNAc sites were mapped by ETD‐MS. Mutation of one of these sites reduces Foxo1a activation by glucose. Pgc‐1α interacts with and targets OGT to Foxo1a, increasing Foxo1a GlcNAcylation. We conclude that hyperglycemia increases GlcNAcylation of Foxo1a via a PGC‐1α:OGT complex, resulting in elevated hepatic gluconeogenesis, exacerbating glucose toxicity in diabetes. Supp. by NIH DK61671, HD13563 (GWH) and GM37537 (DFH). GWH receives royalties on CTD110.6. Mgd. by JHU.
Successive interference cancellation in multistream faster-than-Nyquist Signaling (2006)

In earlier work we have extended Mazo's concept of faster-than-Nyquist signaling to pulse trains that modulate adjacent subcarriers, a method we called two dimensional Mazo signaling. The signal processing is similar to orthogonal frequency division multiplex (OFDM) transmission. Despite pulses that are faster than the Nyquist limit and subcarriers that significantly overlap, the transmission achieves the isolated pulse error performance. In this paper we review the method and test a receiver based on successive interference cancellation. It virtually achieves the matched filter bound.
Synthesis of Thymidine Derivatives 3′-Modified with a Polar Three-Atom Group as Potential Anti-HIV-1 Agents (1992)

Abstract 3′-Modified thymidine analogs, such as 3′-O-[(methylthio)thio-carbonyl]thymidine (4), 3′-O-thiocarbamoylthymidine (7), and N-(3′-deoxy-thymidin-3′-y1)phosphoramidates (9a, b), were synthesized from thymidine derivatives (1), (5), and (8), respectively, as potential anti-human immunodeficiency virus type 1 (HIV-1) agents. No significant activity against HIV-1 was, however, observed with any of these compounds.
Joint deep shape and appearance learning: application to optic pathway glioma segmentation (2017)

Automated tissue characterization is one of the major applications of computer-aided diagnosis systems. Deep learning techniques have recently demonstrated impressive performance for the image patch-based tissue characterization. However, existing patch-based tissue classification techniques struggle to exploit the useful shape information. Local and global shape knowledge such as the regional boundary changes, diameter, and volumetrics can be useful in classifying the tissues especially in scenarios where the appearance signature does not provide significant classification information. In this work, we present a deep neural network-based method for the automated segmentation of the tumors referred to as optic pathway gliomas (OPG) located within the anterior visual pathway (AVP; optic nerve, chiasm or tracts) using joint shape and appearance learning. Voxel intensity values of commonly used MRI sequences are generally not indicative of OPG. To be considered an OPG, current clinical practice dictates that some portion of AVP must demonstrate shape enlargement. The method proposed in this work integrates multiple sequence magnetic resonance image (T1, T2, and FLAIR) along with local boundary changes to train a deep neural network. For training and evaluation purposes, we used a dataset of multiple sequence MRI obtained from 20 subjects (10 controls, 10 NF1+OPG). To our best knowledge, this is the first deep representation learning-based approach designed to merge shape and multi-channel appearance data for the glioma detection. In our experiments, mean misclassification errors of 2:39% and 0:48% were observed respectively for glioma and control patches extracted from the AVP. Moreover, an overall dice similarity coefficient of 0:87&plusmn;0:13 (0:93&plusmn;0:06 for healthy tissue, 0:78&plusmn;0:18 for glioma tissue) demonstrates the potential of the proposed method in the accurate localization and early detection of OPG.
The Use of Interferons in the Treatment of Cutaneous T-Cell Lymphoma (2015)

Interferons are polypeptides that naturally occur in the human body as a part of the innate immune response. By harnessing these immunomodulatory functions, synthetic interferons have shown efficacy in combating various diseases including cutaneous T-cell lymphoma. This article closely examines the qualities of interferon alfa and interferon gamma and the evidence behind their use in the 2 most common types of cutaneous T-cell lymphomas, namely, mycosis fungoides and Sézary syndrome.
Identifying and Evaluating the Potential of Reusing Network Information from Different Flows (2002)

In an internet end system, many applications with various requirements on their data stream transmission run simultaneously. The management of these data streams in a sending end system, and particularly the flow and congestion control for the data streams (if they exist at all), is for each data stream separate and independent from all other data streams.