gebhart/patrepeval huggingface dataset:
Inflammation, TNFα and endothelial dysfunction link lenalidomide to venous thrombosis in chronic lymphocytic leukemia (2011)

Patients receiving lenalidomide are at an increased risk for deep venous thrombosis (DVT). Here, we prospectively investigated the DVT risk in patients with relapsed chronic lymphocytic leukemia (CLL) treated with lenalidomide (n = 32). Five patients developed six incidents of DVT over 1 year for an annual incidence of 16%. Three of these were considered drug-related. Median time to DVT was 105 days (range 56-259 days). No pulmonary embolism was detected. Hypercoagulability screen before study entry was negative in all patients who subsequently developed DVTs. Compared to normal volunteers CLL patients had increased baseline levels of D-dimer, thrombin-antithrombin, soluble vascular endothelial adhesion molecule 1 (sVCAM-1), and thrombomodulin (p < 0.001). After 1 week on lenalidomide D-dimer, thrombomodulin, sVCAM-1, factor VIII, TNFα, and C-reactive protein were significantly increased while protein C was decreased (p < 0.001). In patients with lenalidomide-related DVTs, TNFα, and sVCAM-1 were more strongly upregulated than in all other patients (p < 0.05) and TNFα and sVCAM-1 levels were significantly correlated (r = 0.65, p < 0.001). These data link lenalidomide associated DVTs with TNFα upregulation and endothelial cell dysfunction and suggest that aspirin may have a role for DVT prophylaxis in these patients.
Rapidly Exploring Random Cycles: Persistent Estimation of Spatiotemporal Fields With Multiple Sensing Robots (2016)

This paper considers the problem of planning trajectories for both single and multiple sensing robots to best estimate a spatiotemporal field in a dynamic environment. The robots use a Kalman filter to maintain an estimate of the field value and to compute the error covariance matrix of the estimate. Two new sampling-based path-planning algorithms (rapidly expanding random cycles and an improved variant of rapidly expanding random cycles) are proposed to find periodic trajectories for the sensing robots that minimize the largest eigenvalue of the error covariance matrix over an infinite horizon. The algorithms are proven to find the minimum infinite horizon cost cycle in a random graph, which grows by successively adding random points. The algorithms leverage recently developed methods for periodic Riccati recursions to efficiently compute the infinite horizon cost of the cycles, and they use the monotonicity property of the Riccati recursion to efficiently compare the costs of different cycles without explicitly computing their costs. The algorithms are demonstrated in a study using National Oceanic and Atmospheric Administration data to plan sensing trajectories in the Caribbean Sea. Our algorithms significantly outperform random, greedy, and receding horizon approaches in this environment.
Targeted Protein Degradation Phenotypic Studies Using HaloTag CRISPR/Cas9 Endogenous Tagging Coupled with HaloPROTAC3 (2020)

To assess the role of a protein, protein loss phenotypic studies can be used, most commonly through mutagenesis RNAi or CRISPR knockout. Such studies have been critical for the understanding of protein function and the identification of putative therapeutic targets for numerous human disease states. However, these methodological approaches present challenges because they are not easily reversible, and if an essential gene is targeted, an associated loss of cell viability can potentially hinder further studies. Here we present a reversible and conditional live-cell knockout strategy that is applicable to numerous proteins. This modular protein-tagging approach regulates target loss at the protein, rather than the genomic, level through the use of HaloPROTAC3, which specifically degrades HaloTag fusion proteins via recruitment of the VHL E3 ligase component. To enable HaloTag-mediated degradation of endogenous proteins, we provide protocols for HaloTag genomic insertion at the protein N or C terminus via CRISPR/Cas9 and use of HaloTag fluorescent ligands to enrich edited cells via Fluorescence-Activated Cell Sorting (FACS). Using these approaches, endogenous HaloTag fusion proteins present in various subcellular locations can be degraded by HaloPROTAC3. As detecting the degradation of endogenous targets is challenging, the 11-amino-acid peptide tag HiBiT is added to the HaloTag fusion to allows the sensitive luminescence detection of HaloTag fusion levels without the use of antibodies. Lastly, we demonstrate, through comparison of HaloPROTAC3 degradation with that of another fusion tag PROTAC, dTAG-13, that HaloPROTAC3 has a faster degradation rate and similar extent of degradation. © 2020 The Authors. Basic Protocol 1: CRISPR/Cas9 insertion of HaloTag or HiBiT-HaloTag Basic Protocol 2: HaloPROTAC3 degradation of endogenous HaloTag fusions.
New sunflower oils with high content of phytosterols (2011)

Trabajo presentado en el 9th Euro Fed Lipid Congress, celebrado en Rotterdam del 18 al 21 de septiembre de 2011.
Signal Representation Including Waveform Envelope by Clustered Line-Spectrum Modeling (2003)

Clustered line-spectrum modeling (CLSM) around the peaks of interpolated FFT spectrum records has been developed for signal analysis and representation including the signal envelope. The signal waveform, including the envelope, can be represented by components clustered around spectrum peaks. The sinusoidal components at the peaks are estimated by peak picking, whereas the clustered components required in particular for envelope representation can be estimated by obtaining least-squares error (LSE) solutions in the frequency domain, which was originally formulated by Quatieri and Danisewicz and by Maher. Numerical simulation reveals that the basic CLSM algorithm works well, and a narrow-band speech sample or impulse-response type transient-signal analysis shows that acoustic signals that include envelopes can be expressed quite effectively by using clustered components based on CLSM.
Peroxisome Proliferator-Activated Receptor-Alpha Deficiency Protects Aged Mice from Insulin Resistance Induced by High-Fat Diet (2007)

These data suggest that PPARalpha gene deficiency may protect aged mice from developing insulin resistance and albuminuria induced by a HFD.
Optimal design of bridge SHM systems based on risk and opportunity analysis (2010)

When designing a Structural Health Monitoring system, one should always focus on the specific requirements of the structure under exam. To achieve an optimal design it is however beneficial to follow a well-defined and proven procedure. The first step in the design process consists in identifying the risks and opportunities associated with the bridge under examination. Examples of risks include the probable degradation mechanism due to ageing (e.g. corrosion or fatigue) or external actions (e.g. seismic, impact or overload). Examples of Opportunities include the existence of reserve capacities due to better material properties, synergic effects and over-design. Risks and opportunities are present in both new and existing structures. The purpose of an SHM system is to identify and quantify them, so that the consequences of risks can be avoided (e.g. a collapse) and the benefits of opportunities can be exploited (e.g. safely extending the lifetime of a bridge). Next, the expected responses to the expected degradations and the effects of the possible opportunities are established and an appropriate Structural Health Monitoring Systems is designed to detect such conditions. Only at this stage, the appropriate sensors are selected. When selecting the best sensors for the specific task, it is often necessary and beneficial to combine different measurement technologies. Once the sensors are installed and verified, data collection can start. If these logical steps are followed and the monitoring data is correctly acquired and managed, data analysis and interpretation will be greatly simplified. This process guarantees that each sensor placed in the structure serves at least one specific purpose and leads to a lean and cost-effective system. This paper presents a generalized methodology for designing on optimized Bridge SHM monitoring system and a practical example from a field application: the new I35W Bridge in Minneapolis. methods like visual inspection and modelling. Monitoring even allows a better planning of the inspection and maintenance activities, shifting from scheduled interventions to on-demand inspection and maintenance (Del Grosso, Inaudi, 2004).
Study of Defect Coalescence in Heterogeneous Material Systems Using Broad Band Dielectric Spectroscopy (2017)

American Society for Composites: Thirty-Second &#13;\nTechnical Conference, Purdue University, West Lafayette, Indiana, October 23-25, 2017
Applications of models of binaural hearing (2013)

Models of binaural hearing have been proposed for more than six decades, but it is only recently that they are ready for technological application. Recognizing this situation, 15 laboratories in Europe and in the US have founded a research group, AABBA, with the aim of setting in place "Aural Assessment by Means of Binaural Algorithm". Now, after its first 4-years term of activity, the group has published their recent results in a chapter book (Springer) - including a software package for building customized binaural models. In this talk, the group's most relevant results will be described. The results concern the following areas of model application, among others: Binaural analysis of aural scenes, binaural dereverberation, binaural quality assessment of audio channels, loudspeakers and performance spaces, binaural perceptual coding, binaural processing in hearing aids and cochlea implants, binaural systems in robots, binaural/tactile human-machine interfaces, speech-intelligibility prediction in rooms and/or multi-speaker scenarios. Current members of AABBA are research labs at Universities/Techn. Universities in Helsinki, Boston, Cardiff, Oldenburg, Lyon, Troy NY (Rensselaer), Bochum, Berlin, Copenhagen, Dresden, Eindhoven, Munich, Paris (Pierre et Marie Curie), Toulouse and at the Austrian Academy's Acoustics Research Institute in Vienna
A New System for the Evaluation of Telecom Hardware Robustness (1996)

This paper shows a methodology for hardware design qualification of telecom apparatus, based on a new tool called THRIS (Telecom Hardware Robustness Inspection System). The increase of printed circuit board complexity and integrated circuits speed makes the hardware robustness more and more critical and difficult to evaluate. The manual fault insertion method so far used for overall system robustness evaluation is no more applicable. The fully automatic procedure for fault insertion implemented in THRIS first uses a post-layout description of the board for a signal integrity analysis to pinpoint possible critical areas, then the same information is used to localize the optimum fault insertion point. The fault actuator is based on a miniaturized electronic jumper that allows practically no impact on system performance during normal operation. EMC issues, as switching noise generated in simulated fault conditions, are taken into account and minimized. Further developments of the tool include the prediction of both radiated and conducted EMC issues related to telecom apparatus.
Cyber Security Analysis for the Power Grid Using the Virtual Control Systems Environment. (2016)

Abstract not provided.
Dysobinin, a tetranortriterpenoid (2000)

The planar furan ring in the title compound (6β-acetoxy­aza­dirone, C30H38O6) is twisted with respect to the steroid D ring. The crystal structure is stabilized by C—H⋯O hydrogen bonds and van der Waals interactions.
Portrait: Fachgebiet Telekommunikationsnetze, Technische Universität Berlin (2002)

Article Portrait: Fachgebiet Telekommunikationsnetze, Technische Universität Berlin was published on June 1, 2002 in the journal PIK - Praxis der Informationsverarbeitung und Kommunikation (volume 25, issue 2).
Spatiotemporal Heterogeneity Characterizes the Genetic Landscape of Pheochromocytoma and Defines Early Events in Tumorigenesis (2015)

Genomic landscapes of PPGL are specific to mutation subtype and characterized by genetic heterogeneity both within and between tumor lesions of the same patient.
Convenient Syntheses of Functionalized Dialkyl Ketones and Alkanoylsilanes:  1-(Benzotriazol-1-yl)-1-phenoxyalkanes as Alkanoyl Anion Equivalents (1996)

(Benzotriazol-1-yl)-1-phenoxyalkanes 10, prepared by two-step transformations of the corresponding aldehydes, are readily deprotonated at the methine group by BuLi. Subsequent reactions with alkyl halides, aldehydes, ketones, and imines yield the corresponding substituted derivatives that undergo hydrolysis under acidic conditions to afford the expected functionalized ketones 13, 15,17, 19, 21, 24, and25. Two successive lithiations of (benzotriazolyl)phenoxymethane, each followed by reaction with a trialkylsilyl chloride, alkyl halide, aldehyde, or ketone, generate similar intermediates 27, 29, 31,33, and 36. Subsequent hydrolyses of 27, 29, 31, 33, and 36 yield the functionalized ketones 28, 30, and 32 and the alkanoylsilanes 34 and 37 in good yields.
Supplementary Figure S4 from Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models (2023)

&lt;p&gt;Serum increased asymmetric cell division in GSCs during mitosis.&lt;/p&gt;
Non-Traditional Administration of Remifentanil in an Experimental Setting (2019)

Remifentanil is ultrashort-acting opioid with a unique pharmacokinetic profile. It is used exclusively intravenously. While considering its rapid onset of action and other pharmacokinetic properties, we decided to assess its effects following administration via non-traditional routes. Rabbits (n=10 per each group) were randomized into six groups: remifentanil 1 microg/kg and 3 microg/kg IM, 5.0 and 10.0 microg/kg conjunctivally, and 10 microg/kg and 25.0 microg/kg intranasally. Sedating effects were assessed via a loss of the righting reflex. Secondary, mean arterial blood pressure, arterial oxygen saturation of hemoglobin, and pulse rate was monitored in all rabbits. Non-traditional routes of administration were shown to provide a rapid onset of action as well as fast recovery. Importantly, the administration of remifentanil did not result in any deterioration of cardiovascular functions.
Modeling of optical bending losses in multimode waveguides by ray tracing (1995)

Existing numerical methods of optical waveguide modeling are generally not applicable to the multimode regime because of the enormous computing power required. We have found that a ray tracing algorithm can be useful in modeling multimode waveguides. To test the method, a commercial ray tracing software package was used. Two sets of numerical data from literature on multimode waveguide bending losses were compared with predictions of the ray tracing models; results agree well with the data. This technique can be applied in multimode waveguide design where previous methods were too computing-intensive.
Retrograde cardioplegia in CABG: is it really useful? The microcirculation and a capillary unit model. (2006)

Most surgeons, ourselves including, use retrograde cardioplegia in numerable operations in cardiac surgery. It is believed to be not only supplementary to antegrade, but also a unique alternative in special complicated cases. Regarding CABGs (coronary artery bypass grafts), many authors advocate its routine use together with antegrade, while others do not suggest it for standard practice. The existing disagreement on this special item is consequential to the different results among various protocols which have studied the effect of antegrade and retrograde perfusion. In these studies, fundamental variations in design, materials, and methods have resulted in an inability to compare results. Additionally, most of the published protocols studying cardioplegic arrest offer only a gross estimation of the microcirculatory perfusion, which is the basis of myocardial protection. Our present review is an attempt to elucidate the differences, explain the necessity of comparing retrograde cardioplegia alone with antegrade in CABGs for the reproduction of safe results, clarify the role of Thebesian veins and venovenous connections during retroperfusion, consider the critical anatomic differences between human hearts and those of animals which may result in serious study bias, and, finally, offer an explanation of what may really be going on in the microcirculation during antegrade and retrograde perfusion using a human capillary model.
Layer 4 Optimizer (L4O) for Enhancing Battery Life in Smart Devices (2018)

Applications (Apps) in Smart devices make our life connected to Internet all the time. But, the battery capacity is a major setback for Internet connected Smart phones. We know that TCP is the backbone protocol for these Internet data transmissions. In this paper, we studied the impacts of TCP connection flow on Smart phone battery. We have conducted extensive experiments and collected data from various operator networks in different countries. We observe that TCP delayed closures at the client and prolonged TCP zero Window probes (ZWP) from the server lead to increased signaling overhead and radio ON time. These phenomenon cause unwanted battery drain at the smart phones. To address these problems, we propose a solution that prevents unnecessary packet communication due to TCP delayed closures and ZWPs. Our solution has been evaluated for Android devices such as Samsung Galaxy S7 and S8 variants and Tizen device such as Samsung Z3. We have found that, our solution consistently achieves 10 to 20% of power usage reduction irrespective of varying network and traffic conditions.
Explanation of Displacement Current in a Vacuum (2006)

It is considered that the time derivative of the electric intensity in the Maxwell-Ampere law (displacement current) denotes that a change of electric field generates a magnetic field. This paper shows that there is no reason to think a change of electric field generates a magnetic field and the displacement current term has a different meaning. It is necessary to be aware of distant conductors and their magnetic fields.
Vascular smooth muscle contractility depends on cell shape (2011)

The physiologic role of smooth muscle structure in defining arterial function is poorly understood. We aimed to elucidate the relationship between vascular smooth muscle architecture and functional contractile output. Using microcontact printing and muscular thin film technology, we engineered in vitro vascular tissues with strictly defined geometries and tested their contractile function. In all tissues, vascular smooth muscle cells (VSMCs) were highly aligned with in vivo-like spindle architecture, and contracted physiologically in response to stimulation with endothelin-1. However, tissues wherein the VSMCs were forced into exaggerated spindle elongation exerted significantly greater contraction force per unit cross-sectional area than those with smaller aspect ratios. Moreover, this increased contraction did not occur in conjunction with an increase in traditionally measured contractile phenotype markers. These results suggest that cellular architecture within vascular tissues plays a significant role in conferring tissue function and that, in some systems, traditional phenotype characterization is not sufficient to define a functionally contractile population of VSMCs.
Figuring of Elliptical Neutron Focusing Mirror Using Numerically Controlled Local Wet Etching (2009)

Numerically controlled local wet etching is a novel figuring method for fabricating the ultraprecision optical components and/or finishing the functional materials. In this method, localized wet etching area is formed by applying the combination nozzle which consists of a supply part and a suction part of an etchant, and the removal volume at any point on the workpiece surface is determined by the dwelling time of the nozzle. In this paper, we proposed the two-step figuring process, which consists of a rough figuring process by applying a one-dimensional numerically controlled scanning using a large rectangular nozzle and a finishing process by applying two-dimensional numerically controlled scanning using a small circular nozzle, for figuring the plano-aspherical mirror. By applying the two-step figuring process, we fabricated the plano-elliptical neutron focusing mirror with the figure accuracy of less than 0.5 µm and succeeded in achieving the focusing gain of 6.
Temporal Pattern of Pain Relief Using CyberKnife Radiosurgery for Trigeminal Neuralgia: A Preliminary Report (2004)

Radiosurgery is a non-invasive alternative to treat medically refractory trigeminal neuralgia (TN) in selected patients. Several reports have described outcomes after gamma knife radiosurgery (GKR) for TN. We have recently treated a small cohort of patients with TN using a Linac-based frameless radiosurgical device, the CyberKnife (Accuray Inc., Sunnyvale, Calif., USA). Stereotactic irradiation is delivered by a compact 6-MV x-ray Linac moved and pointed by a precise and highly maneuverable robotic arm. Real-time image guidance using amorphous silicone detectors outlines the contour of the patient’s skull and provides accurate localization without requiring a rigid stereotactic frame. Preliminary results in 13 patients were encouraging; 7 patients (53.8%) developed pain relief within a week, and overall, 8 patients (61.5%) experienced a long-lasting satisfactory outcome. Reduced constraints on treatment planning due to the absence of a stereotactic ring, improved targeting accuracy produced by computed tomographic cisternography, and conformal dosimetry may explain the early onset of analgesia in a large subset of treated patients. These results should be considered preliminary, however, and need to be confirmed by a prospective study on a larger patient sample.
Assessment of Instabilities of Conventional and Deep Learning Multi-Coil MRI Reconstruction at Multiple Acceleration Factors (2023)

Although deep learning has received much attention for accelerated MRI reconstruction, it shows instabilities to certain tiny perturbations resulting in substantial artifacts. There has been limited work comparing the stability of DL reconstruction with conventional reconstruction methods such as parallel imaging and compressed sensing. In this work, we investigate the instabilities of conventional methods and the Variational Network (VN) with different accelerations. Our results suggest that CG-SENSE with an optional regularization is also impacted by perturbations but shows less artifacts than the VN. Each reconstruction method becomes more vulnerable with higher acceleration and VN shows severe artifacts with 8-fold acceleration.
Iconography : Histamine detection using functionalized porphyrin as electrochemical mediator (2017)

Comptes Rendus Chimie - In Press.Proof corrected by the author Available online since samedi 8 juillet 2017