gebhart/patrepeval huggingface dataset:
Small Molecule Library Synthesis Using Segmented Flow (2011)

Flow chemistry has gained considerable recognition as a simple, efficient, and safe technology for the synthesis of many types of organic and inorganic molecules ranging in scope from large complex natural products to silicon nanoparticles. In this paper we describe a method that adapts flow chemistry to the synthesis of libraries of compounds using a fluorous immiscible solvent as a spacer between reactions. The methodology was validated in the synthesis of two small heterocycle containing libraries. The reactions were performed on a 0.2 mmol scale, enabling tens of milligrams of material to be generated in a single 200 mL reaction plug. The methodology allowed library synthesis in half the time of conventional microwave synthesis while maintaining similar yields. The ability to perform multiple, potentially unrelated reactions in a single run is ideal for making small quantities of many different compounds quickly and efficiently.
Gastrointestinal bleeding due to marked coagulopathy from acute kidney injury in a patient taking dabigatran (2015)

1) (acute kidney injury, AKI) 71 3 220 mg/day BUN 9.3 mg/dlCr 0.71 mg/dl (activated partial thromboplastin time, APTT)31.6 sec 110 2 vital sign Hb 7.8 g/dlBUN 165.6 mg/dl Cr 12.67 mg/dl (prothrombin time-international normalized ratio, PT-INR)6.42APTT 129.9 sec
Social TV (2011)

Internet Television (IPTV) is emerging as a new delivery method for offering access to digital TV and interactive services which potentially merge the “lean back” broadcast experience with more bidirectional “lean forward” interactivity. Within these environments, there is a significant growth in the volume and variety of content being offered which increases the difficulty and burden for the end-user in locating relevant content and finding something to watch. In this article we detail the design, implementation, and evaluation of a production IPTV service which operates on our University campus network. Our approach makes use of social networks as a mechanism for providing social awareness to individual users of an IPTV system. The goal is to facilitate an intuitive and simple media selection mechanism when considering vast amounts of live TV channels and on-demand content. Ultimately, we seek to explore whether social awareness can or does influence user behavior.
Highly efficient deep desulfurization of fuels by chemical oxidation (2004)

This paper describes the oxidation of several model S-containing molecules with hydrogen peroxide in a two liquid–liquid (L–L) phase system with a phase transfer catalyst under atmospheric pressure in the 333–353 K temperature range. The influence of the reaction temperature, the nature of the substrate, the solvent, the molar ratio of the oxidant (H2O2) and the S-containing molecule were examined. The reaction rates of the oxidative desulfurization (ODS) reaction were found to increase with the temperature, and with the molar ratio of H2O2 and the S-containing molecule. The potential of this methodology is illustrated by the complete S-removal from a 5.0 wt% dibenzothiophene mixture at 353 K, under excess of H2O2 oxidant in less than three hours of reaction. In addition, the ODS reaction was strongly enhanced when the water solvent was replaced by acetonitrile. The very high ODS reaction rate observed with the acetonitrile solvent could be explained in terms of the much higher solubility of the sulfone reaction product in this solvent and also by its very low surface tension, which facilitates the transfer of products and reagents at the polar–apolar interface. Finally, the very mild sulfoxidation reaction was applied to a kerosene fraction. The results revealed that S-levels below 25 ppm are achieved at 353 K upon using a H2O2 ∶ substrate molar ratio of 2.5 ∶ 1.
Stimulation of rat liver mitochondrial adenosine triphosphatase by anions. (1975)

The hydrolysis of MgATP by isolated rat liver mitochondrial ATPase (EC 3.6.1.3) at pH 8.0 was stimulated by various anions. The rate of hydrolysis was increased from 18 to 170 mumol per min per mg, a 9.4-fold stimulation, by HSeO3 at 1 mM MgATP. In the absence of a stimulatory anion, reciprocal plots of initial velocity studies with MgATP as the variable substrate were curved (Hill coefficient approximately 0.5). With the addition of anion, the reciprocal plots became linear. When the substrate was MgITP or MgGTP with the isolated enzyme or MgATP with submitochondrial particles, no curvature of the reciprocal plots was observed. With purified ATPase, anions stimulated the hydrolysis of MgITP, MgGTP, MgUTP or MgCTP only slightly. With submitochondrial particles the stimulation by anions of MgATP hydrolysis was limited to approximately 2-fold. These data are interpreted to indicate the existence of two substrate sites for MgATP and an anion-binding site on the isolated enzyme.
Biological characterization of folic acid-conjugated poly(H<sub>2</sub>NPEGCA-<i>co</i>-HDCA) nanoparticles in cellular models (2007)

The folate receptor (FR) is a highly selective tumor marker over expressed in many human cancers and it constitutes a useful target for tumor-specific drug delivery. Thus, the conjugation of folic acid to different drugs or drug carriers may enhance the delivery of the therapeutic agent to FR-positive tumor cells. The aim of this study was to investigate the interactions of folate-conjugated polyalkylcyanoacrylate nanoparticles with tumor cells overexpressing the FR. For this purpose, nanoparticles were prepared by nanoprecipitation of the poly[aminopoly(ethylene glycol) cyanoacrylate-co-hexadecyl cyanoacrylate] [poly(H2NPEGCA-co-HDCA)] copolymer and labeled with the hydrophobic fluorescent dye nile red. Nile red-loaded nanoparticles were then conjugated to folic acid via the PEG terminal amino groups. Four human cancer cell lines were then tested by western blot in order to evaluate the FR expression levels. KB3-1 cell line showed the higher expression level, while MCF-7 cells were taken as a control. After measuring the cytotoxicity of the nanoparticles on these two cell lines, fluorescent folate-nanoparticles were incubated with them and the cellular uptake was evaluated by confocal microscopy and flow cytometry. KB3-1 cells showed a greater nanoparticle internalization, when compared to MCF-7 cells.
Erosion of Embolization Coils into the Renal Collecting System Mimicking Stone (2012)

Urinary tract interventions can lead to multiple complications in the renal collecting system, including retained foreign bodies from endourologic or percutaneous procedures, such as stents, nephrostomy tubes, and others. We report a case of very delayed erosion of embolization coils migrating into the renal pelvis, acting as a nidus for stone formation, causing mild obstruction and finally leading to gross hematuria roughly 18 years post transarterial embolization. History is significant for a remote unsuccessful endopyelotomy attempt that required an urgent embolization.
The cellular toxicology of mitragynine, the dominant alkaloid of the narcotic-like herb, Mitragyna speciosa Korth (2015)

The cytotoxicity of mitragynine, the dominant alkaloid of the narcotic-like herb,<italic>Mitragyna speciosa</italic>Korth (Kratom) involves cell cycle arrest, apoptosis and opiate receptors.
Hydrogen Materials Advanced Research Consortium (HyMARC): Sandia Technical Effort. (2020)

Abstract not provided.
A 32-dB SNR Readout IC With 20-Vpp Tx Using On-Chip DM-TISM in HV BCD Process for Mutual-Capacitive Fingerprint Sensor (2019)

This brief presents a readout IC with a 20 V high-voltage (HV) transmitter (Tx) and On-Chip Differentially Modulated Time-Interleaved Sensing Method (DM-TISM) in a BCD process for a mutual-capacitive Transparent Fingerprint Sensor (TFPS) in order to achieve high SNR, AC & DC offset reduction, high noise immunity, and compensate for the signal loss under thick cover glass. A proposed readout IC with onchip DM-TISM is composed of 42 identical HV Tx channels, 32 identical Rx channels, and a diamond-patterned TFPS. The performance results including those for transient noise show that the DM-TISM achieves greater SNR than conventional TISM. The measured raw data show that the proposed readout IC achieves SNR of 32 dB with current consumption of 25 mA for the Tx and 13 mA for the Rx. It can be applied to any type of mobile device that needs fingerprint recognition. The ICs for the Tx and Rx are fabricated using 0.25-μm BCD process and 0.18-μm CMOS process with 1.6 mm × 3.5 mm and 2.5 mm × 2.5 mm areas, respectively.
Spectroscopic studies of specifically deuterium labeled membrane systems. Nuclear magnetic resonance investigation of protein-lipid interactions in Escherichia coli membranes (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic studies of specifically deuterium labeled membrane systems. Nuclear magnetic resonance investigation of protein-lipid interactions in Escherichia coli membranesS. Y. Kang, H. S. Gutowsky, and Eric OldfieldCite this: Biochemistry 1979, 18, 15, 3268–3272Publication Date (Print):July 1, 1979Publication History Published online1 May 2002Published inissue 1 July 1979https://doi.org/10.1021/bi00582a011RIGHTS & PERMISSIONSArticle Views55Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alerts Get e-Alerts
Feedback control simulation of power electronic converters for renewable energies (2009)

A possible workflow for designing high power electronic converters for using with renewable sources, such as wind energy farms, is proposed. It takes care of both the control strategies and the electrical characteristics of the electron devices (as IGBTs and PiN diodes) used for the converter. The control feedback loop is designed by using a MATLAB/SIMULINKtrade based model, while a more detailed electron device behavior is investigated with other simulation tools, such as PSPICE, in order to obtain a correct evaluation of switching and conduction power losses and to estimate the efficiency of the converter. Application on a machine-side converter for wind turbine is shown.
Exploiting the Intrinsic Neighborhood Structure for Source-free Domain Adaptation (2021)

Domain adaptation (DA) aims to alleviate the domain shift between source
domain and target domain. Most DA methods require access to the source data,
but often that is not possible (e.g. due to data privacy or intellectual
property). In this paper, we address the challenging source-free domain
adaptation (SFDA) problem, where the source pretrained model is adapted to the
target domain in the absence of source data. Our method is based on the
observation that target data, which might no longer align with the source
domain classifier, still forms clear clusters. We capture this intrinsic
structure by defining local affinity of the target data, and encourage label
consistency among data with high local affinity. We observe that higher
affinity should be assigned to reciprocal neighbors, and propose a self
regularization loss to decrease the negative impact of noisy neighbors.
Furthermore, to aggregate information with more context, we consider expanded
neighborhoods with small affinity values. In the experimental results we verify
that the inherent structure of the target features is an important source of
information for domain adaptation. We demonstrate that this local structure can
be efficiently captured by considering the local neighbors, the reciprocal
neighbors, and the expanded neighborhood. Finally, we achieve state-of-the-art
performance on several 2D image and 3D point cloud recognition datasets. Code
is available in https://github.com/Albert0147/SFDA_neighbors.
HEVC Video Coding with Deep Learning Based Frame Interpolation (2020)

Recent researches in video frame interpolation show great progress. In this paper, we propose a novel video compression method which incorporates deep learning based frame interpolation into HEVC which is the current video compression standard. Experimental results show that our approach can outperform HEVC in some scenarios.
Data from The Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) Enhances the Radiation Responsiveness of Lung and Colorectal Tumor Xenografts (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Novel molecularly targeted agents, given in combination with radiotherapy, have the potential to increase tumor response rates and the survival of patients with lung cancer. AZD6244 is a potent and selective inhibitor of mitogen-activated protein kinase (MAPK) kinase 1/2 (MEK1/2), a critical enzyme within the MAPK/extracellular signal-regulated kinase (ERK) signaling pathway that regulates the proliferation and survival of tumor cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; This study examined the potential benefit of combining AZD6244 with fractionated radiotherapy using human lung and colon carcinoma xenograft models.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; AZD6244 reduced ERK phosphorylation in Calu-6 lung cancer cells &lt;i&gt;in vitro&lt;/i&gt;. Administration of AZD6244 for 10 days (25 mg/kg twice daily p.o.) inhibited the tumor growth of Calu-6 xenografts, with regrowth occurring on cessation of drug treatment. When fractionated tumor-localized radiotherapy (5 × 2 Gy) was combined with AZD6244 treatment, the tumor growth delay was enhanced significantly when compared with either modality alone, and this effect was also seen in a colon tumor model. We examined the effect of inhibiting MEK1/2 on the molecular responses to hypoxia, a potential interaction that could contribute to radioresponsiveness. AZD6244 reduced hypoxia-inducible factor–specific transactivation &lt;i&gt;in vivo&lt;/i&gt;, shown using Calu-6 dual clone cells that stably express a &lt;i&gt;Firefly&lt;/i&gt; luciferase gene under the control of a hypoxia-driven promoter. Furthermore, hypoxia-inducible factor-1α, GLUT-1, and vascular endothelial growth factor levels were reduced by AZD6244, and there was a significant decrease in vascular perfusion in the tumors given combination treatment when compared with the other treatment groups.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; These data provide support for the clinical development of AZD6244 in combination with radiotherapy and indicate a potential role for AZD6244 in inhibiting the tumor hypoxia response. (Clin Cancer Res 2009;15(21):6619–29)&lt;/p&gt;&lt;/div&gt;
A new robust robot controller (1986)

A new method is proposed for the accurate trajectory control of a general n degree of freedom robot manipulator, in the presence of large unknown parameter perturbations. In particular, joint friction and large payload mass perturbations are considered. It is demonstrated that for the particular control scheme considered, the choice of high gain feedback results in a system which gives good performance even in the presence of large unmodelled parameter uncertainties. Sufficient conditions for stability are derived using a local subsystem approach. A numerical simulation of a two degree of freedom manipulator, with a large unknown payload mass is included illustrating the new controller design.
130 Study of Practical Method to Analyze Multi Layer Noise Transfer Path (2009)

The new practical method has been developed to analyze multi layer noise transfer paths. The method evaluates transmissibility of the sound and vibration between each of the layers as transmissibility matrix. Thus the noise transfer paths from multiple sources can be represented by a series of sound and vibration transmissibility matrices. Applications of our method to the cabin noise of construction machinery showed that the method could identify the dominant noise transfer path, analyze the noise generation mechanism and predict noise reduction effect.
Usability issues in utilizing context metadata in content management of mobile devices (2004)

Mobile devices and their novel applications are handling increasing amounts of new type of content such as video, images, messages and music. Managing large amounts of data introduces a usability challenge that cannot be solved without developing new ways of managing the content. The use of context metadata is presented here as one of the ways to aid content management. This paper investigates the usability issues that are introduced by the usage of context metadata such as time, date, location and proximity. The research was based on literature, expert groups, focus groups and interviews. The usability issues that were identified were related to meaningfulness, to usefulness and to privacy. A vast amount of issues need to be solved to implement a safe, easy-to-use and preferably automated way of assisting users to manage their mobile content with context metadata.
Technologien zur In-vivo-Untersuchung der Biomechanik der Hornhaut: Brillouin-Spektroskopie und Hydratationszustand – quo vadis? (2022)

To assess the structural integrity of the cornea, non-invasive methods are needed for the local measurement of its mechanical properties. Among a number of established techniques and their associated advantages and disadvantages, Brillouin spectroscopy is still a relatively new technique, capable of determining the compressive modulus of biological tissue, specifically the cornea, in vivo. In the present paper, these various existing and developing technologies for corneal biomechanics are discussed and correlated.
Antibacterial protein-based fibres: combining recombinant DNA technology with electrospinning (2017)

[Excerpt] With the increasing healthcare-associated infections and antibiotic-resistant microorganisms there is a demand not only for new antimicrobial compounds but also for antimicrobial materials. Genetically engineered protein polymers functionalized with bioactive domains offer potential as multifunctional versatile materials for biomedical use. The present work describes the fabrication and characterization of antimicrobial fibre mats comprising the antimicrobial elastin-like recombinamer CM4-A200 [1]. [...]
Evaluation of Global Versus Piecewise Registration Using a Ground Truth Canine Model (2006)

Minimally invasive cardiac catheter ablation procedures for treatment of myocardial arrhythmias require effective visualization of the relevant heart anatomy and electrophysiology. In a typical ablation procedure, the visualization tools available to the cardiologist include fluoroscopy, ultrasound, and a coarse 3D model of cardiac anatomy and electrical activity. Recent advances in visualization techniques for cardiac ablation procedures have provided the capability to incorporate detailed, patient specific anatomical image data into the procedure. One of the main challenges, however, lies in registering tracked catheter points collected during the procedure to preoperative, patient specific data. While cardiac gating can help to compensate for motion throughout the cardiac cycle, respiratory motion still remains an issue. In a previous simulation study, we showed that piecewise linear registration performs better than global registration for this application. There are two main goals of the current work. First, we generate a ground truth dataset that can be used to evaluate the performance of registration techniques in the application of cardiac ablation procedures. Second, we use this dataset to compare the performance of global versus piecewise registration
A note on the use of the two‐stream delta‐scaling approximation for calculating atmospheric photolysis rate coefficients (1996)

The delta‐scaling approximation is widely used in radiative transfer models to improve the accuracy of calculated irradiances under strongly forward scattering conditions. At completion of the scaled radiative transfer calculations, the inverse transformation (or descaling) is applied to partition the total downward irradiance, which is assumed invariant with respect to the scaling/descaling transformation, into its diffuse and direct components. However, this invariance does not apply to the total downward actinic flux, and ambiguities arise when the actinic flux components are calculated from either scaled or descaled components of the irradiance. The problem is particularly severe in two‐stream models because of the lack of angular resolution. We use a realistic example (the calculation of the photodissociation rate coefficient, or J value, for the photolysis reaction NO 2 → NO + O ( 3 P )) to show in particular that, for high Sun and low surface albedo, the use of descaled J values leads to large overestimation of rather constant or modest increases of J values below a thin cloud or aerosol layer. Even larger overestimations of J values are found near the top of a thick cloud layer at high Sun when descaling is used. Use of scaled values appears preferable under most practical conditions, although they, too, suffer from inaccuracies generally associated with two‐stream methods.