gebhart/patrepeval huggingface dataset:
SHF-Band 3-bit Reconfigurable BPF Employing pHEMT Switch Arrays for 5G Multiband Operation (2019)

For the efficient use of frequency spectrum under multi-band operation in 5th generation mobile communication (5G), RF circuits that can flexibly switch multiple bands are important. Three-bit reconfigurable bandpass filters (BPF) have been proposed that can choose one of eight center frequencies in UHF or SHF bands. However, the RF switches employed for the frequency switching have been treated as ideal component and not studied in detail. In this paper, we focus on the FET switches in the reconfigurable BPF for SHF band and analyze the influence of their parasitic elements on the performance of BPF. In order to reduce insertion loss of the BPF, a new gate width design method for RF switch array (SWA) is proposed. A 3-bit RF SWA is fabricated using 0.5 μm gate pHEMT process and installed in the prototype BPF with passband center frequency changeable from 3.5 to 4.64 GHz. The measured RF characteristic of the prototype is close to the result of circuit simulation.
Lane Keeping Support (2011)

Während längerer Fahrten auf autobahnähnlichen Straßen wird die Fahraufgabe des Spurhaltens von vielen Fahrern als lästig empfunden. Andererseits stellt das unbeabsichtigte Verlassen des Fahrstreifens eine häufige Unfallursache dar, wie bereits in Kapitel 34 beschrieben. Im Gegensatz zu der im vorigen Kapitel dargelegten Funktion des Lane Departure Warning (LDW) greift die hier beschriebene Spurhalteassistenz bzw. Lane Keeping Support (LKS) aktiv in das Lenksystem ein. Dadurch wird der Fahrer bei der Fahraufgabe des Spurhaltens unterstützt. Ziel dieser Funktion ist, je nach Auslegung, eine Erhöhung der Sicherheit, eine Erhöhung des Fahrkomforts oder eine Kombination beider Ziele. Ein wichtiges Merkmal der hier beschriebenen Systeme ist die Art der Assistenz, die über Warnungen hinausgeht, jedoch keine den Fahrer ersetzende Assistenz darstellt. Die motorische Ausführung der Lenkung des Fahrzeugs erfolgt somit durch den Fahrer und das LKS-System zugleich. Das Einsatzgebiet der heute verfügbaren Systeme erstreckt sich über autobahnähnliche Straßen in mittleren bis hohen Geschwindigkeiten und sichtbaren Markierungen der Fahrstreifen.
A Wafer Transfer Technology for MEMS Adaptive Optics (2001)

Abstract Adaptive optics systems require the combination of several advanced technologies such as precision optics, wavefront sensors, deformable mirrors and lasers with highspeed control systems. The deformable mirror with a continuous membrane is a key component of these systems. This paper describes a new technique for transferring an entire wafer-level silicon membrane from one substrate to another. This technology is developed for the fabrication of a compact deformable mirror with a continuous face sheet. A 1 μm thick silicon membrane, 100 mm in diameter, has been successfully transferred without using adhesives or polymers (i.e. wax, epoxy, or photoresist). Smaller or larger diameter membranes can also be transferred using this technique. The fabricated actuator membrane with an electrode gap of 1.5 μm shows a vertical deflection of 0.37 μm at 55 V. The proposed technique has the following benefits over those previously reported: 1) No post-assembly release process (e.g. using HF) is required, and no wax, photoresist, or epoxy is used for the transfer purpose 2) The bonded interface is completely isolated from any acid, etchant, or solvent, which ensures a clean and flat membrane surface. 3) It offers the capability of transferring wafer-level membranes over deformable actuators.
Direct Oxidation of Cycloalkanes to Cycloalkanones with Oxygen in Water (2013)

It doesn′t take much to oxidize cycloalkanes directly to the corresponding cyclic ketones: molecular oxygen as the oxidant, water as the solvent, the cofactor NADP+ (and a little 2-propanol to reduce it), as well as two catalytic enzymes—a hydroxylating P450 monooxygenase and an alcohol dehydrogenase (see scheme).
The Chain of Adherence for Incidentally Detected Pulmonary Nodules after an Initial Radiologic Imaging Study: A Multisystem Observational Study (2022)

<b>Rationale:</b> Millions of people are diagnosed with incidental pulmonary nodules every year. Although most nodules are benign, it is universally recommended that all patients be assessed to determine appropriate follow-up and ensure that it is obtained. <b>Objectives:</b> To determine the degree of concordance and adherence to 2005 Fleischner Society guidelines among radiologists, clinicians, and patients at two Veterans Affairs healthcare systems with incidental nodule tracking systems. <b>Methods:</b> Trained researchers abstracted data from the electronic health records of patients with incidental pulmonary nodules as identified by interpreting radiologists from 2008 to 2016. We classified radiology reports and patient follow-up into three categories. Radiologist-Fleischner adherence was the agreement between the radiologist's recommendation in the computed tomography (CT) report and the 2005 Fleischner Society guidelines. Clinician/patient-Fleischner concordance was agreement between patient follow-up and the guidelines. Clinician/patient-radiologist adherence was agreement between the radiologist's recommendation and patient follow-up. We evaluated whether the recommendation or follow-up was more (e.g., sooner) or less (e.g., later) aggressive than recommended. <b>Results:</b> After exclusions, 4,586 patients with 7,408 imaging tests (<i>n</i> = 4,586 initial chest CT scans; <i>n</i> = 2,717 follow-up chest CT scans; <i>n</i> = 105 follow-up low-dose CT scans) were included. Among radiology reports that could be classified in terms of Fleischner Society guidelines (<i>n</i> = 3,150), 80% had nonmissing radiologist recommendations. Among those reports, radiologist-Fleischner adherence was 86.6%, with 4.8% more aggressive and 8.6% less aggressive. Among patients whose initial scans could be classified, clinician/patient-Fleischner concordance was 46.0%, 14.5% were more aggressive, and 39.5% were less aggressive. Clinician/patient-radiologist adherence was 54.3%. Veterans whose radiology reports were adherent to Fleischner Society guidelines had a substantially higher proportion of clinician/patient-Fleischner concordance: 52.0% concordance among radiologist-Fleischner adherent versus 11.6% concordance among radiologist-Fleischner nonadherent. <b>Conclusions:</b> In this multi-health system observational study of incidental pulmonary nodule follow-up, we found that radiologist adherence to 2005 Fleischner Society guidelines may be necessary but not sufficient. Our results highlight the many facets of care processes that must occur to achieve guideline-concordant care.
Ser71 Phosphorylation Inhibits Actin-Binding of Profilin-1 and Its Apoptosis-Sensitizing Activity (2021)

The essential actin-binding factor profilin-1 (Pfn1) is a non-classical tumor suppressor with the abilities toboth inhibit cellular proliferation and augment chemotherapy-induced apoptosis. Besides actin, Pfn1 interacts with proteins harboring the poly-L-proline (PLP) motifs. Our recent work demonstrated that both nuclear localization and PLP-binding are required for tumor growth inhibition by Pfn1, and this is at least partially due to Pfn1 association with the PLP-containing ENL protein in the Super Elongation Complex (SEC) and the transcriptional inhibition of pro-cancer genes. In this paper, by identifying a phosphorylation event of Pfn1 at Ser<sup>71</sup> capable of inhibiting its actin-binding and nuclear export, we provide <i>in vitro</i> and <i>in vivo</i> evidence that chemotherapy-induced apoptotic sensitization by Pfn1 requires its cytoplasmic localization and actin-binding. With regard to tumor growth inhibition byPfn1, our data indicate a requirement for dynamic actin association and dissociation rendered by reversible Ser<sup>71</sup>phosphorylation and dephosphorylation. Furthermore, genetic and pharmacological experiments showed that Ser<sup>71</sup> of Pfn1 can be phosphorylated by protein kinase A (PKA). Taken together, our data provide novel mechanistic insights into the multifaceted anticancer activities of Pfn1 and how they are spatially-defined in the cell and differentially regulated by ligand-binding.
The Shair Synthesis of Cephalostatin 1 (2013)

The cephalostatins and ritterazines, represented by cephalostatin 1 3, have the remarkable property of inducing apoptosis in apoptosis-resistant malignant cell lines. The total synthesis ( J. Am. Chem. Soc. 2010, 132, 275) of 3 by Matthew D. Shair of Harvard University required the practical preparation of the complex hexacyclic ketones 1 and 2. The preparation of 1 started with irradiation of commercial hecogenin acetate 4 to give the known aldehyde 5 . Reaction of 5 with N -phenyltriazolenedione 6 led to the ketal 7. Oxidative cleavage generated an aldehyde, which on reduction and allylation was converted to 8. Acid-mediated cyclization led to 9. The sidechain of 9 was removed, giving 10, which was selectively reduced, leading to 11. Intramolecular aldol condensation gave 12. The relative configuration of the spiroketal 1 was established by kinetic bromoetherification of the alcohol 13, followed by free radical reduction of the resulting tertiary bromide, and acid-catalyzed equilibration. The synthesis of 2 began with the inexpensive steroid 14. Following the Schönecker protocol, C-H functionalization led to the ketone 15. Pd-mediated coupling of the derived enol triflate with the alkyne gave 16, which was oxidized and cyclized to 17. Simmons-Smith conditions converted the dihydrofuran of 17 into the cyclopropane, which was again opened kinetically with Br (NBS) to set the relative configuration of the spiroketal. Free radical reduction followed by protection and oxidation then completed the preparation of 2. The coupling of 1 and 2 (not illustrated) to form the central pyrazine of 3 followed the precedent of Fuchs, combining the 2-azido ketone derived from 1 with the 2-amino methoxime derived from 2. Remarkably, tens of milligrams of 1 and of 2 were prepared, assuring a reasonable supply of 3 for further studies.
Aneurysmal subarachnoid hemorrhage induces the expression of Pentraxin3 in patients (2007)

Aneurismal subarachnoid hemorrhage (SAH) is an extremely severe illness associated with a high mortality rate and permanent severe neurological dysfunction in two-thirds of all affected patients. One of the major complications of SAH is vasospasm-associated cerebral ischemia. Clinical and experimental data suggest that vasospasm is linked to the inflammatory response associated with SAH. The goal of this study was to investigate the expression of Pentraxin3 (PTX3), a prototypic long pentraxin protein induced by proinflammatory signals in the brain, in SAH patients to test the hypothesis that SAH is followed by an upregulation of PTX3, and establish a temporal relationship between the expression of PTX3 and the induction of vasospasm. We also attempted to establish that PTX3 is detectable in cerebrospinal fluid (CSF).
Targeted fluorescent gold nanocluster for NIR imaging (Conference Presentation) (2023)

Fluorescent gold nanoclusters (AuNCs) with emission in near infrared (NIR) range have drawn wide attention due to its bright fluorescence, good biocompatibility and photostability. In this work, AuNCs with emission at 800 nm were synthesized through a simple glutathione reduction method through heating. Cyclic RGD peptide will be conjugated through thiol-PEG-amine as targeting ligand. The AuNCs are then used for two photon fluorescent imaging, due to the wide stokes shift. In vivo NIR fluorescent study showed the accumulation of the AuNCs in tumor areas. Moreover, the AuNCs also showed brain uptake, which indicates possible applications in brain imaging.
PD Sliding Mode Controller based Decoupled Aerial Manipulation (2020)

This paper presents the design of 3-Dof multi-link robot arm that is mounted on the multirotor. To be considered
the dynamic characteristics of the manipulation platform, the decoupled dynamic models of the system
are derived. The main advantage of the first joint is introduced for more robustness and stability during hovering.
The PID controller will be implemented for position and attitude of multirotor control, whereas, a sliding
mode controller will be designed for a manipulator robot, which is then compared with the sliding surface
that has been integrated with the proportional-derivative (PD) controller. The performance of the proposed
technique is demonstrated through a simulation using Simulink and Matlab environment.
Human SAA1-derived amyloid deposition in cell culture: a consistent model utilizing human peripheral blood mononuclear cells and serum-free medium (2013)

Amyloid A (AA) amyloidosis is a fatal disease caused by extracellular deposition of fibrils derived from serum AA (SAA). AA amyloid fibril formation has previously been modeled in macrophage cultures using highly amyloidogenic mouse SAA1.1, but attempts to do the same with human SAA invariably failed. Our objective was to define conditions that support human SAA-derived amyloid formation in peripheral blood mononuclear cell (PBMC) cultures. Two conditions were found to be critical – omission of fetal calf serum and use of StemPro34, a lipid-enriched medium formulated for hematopoietic progenitor cells. Cultures maintained in serum-free StemPro34 and provided with recombinant human SAA1 in the complete absence of amyloid-enhancing factor exhibited amyloid deposition within 7 d. Amyloid co-localized with cell clusters that characteristically included cells of fibrocytic/dendritic morphology as well as macrophages. These cells formed networks that appeared to serve as scaffolding within and upon which amyloid accumulated. Cells in amyloid-forming cultures demonstrated increased adherence, survival and expression of extracellular matrix components. Of the three human SAA1 isoforms, SAA1.3 showed the most extensive amyloid deposition, consistent with it being the most prevalent isoform in Japanese patients with AA amyloidosis. Attesting to the reproducibility and general applicability of this model, amyloid formation has been documented in cultures established from eight PBMC donors.
DEMOGRAPHICS AND THE MARKETING OF ASIAN AND HISPANIC PRODUCE IN THE EASTERN COASTAL U.S.A. (2007)

The authors acknowledge several individuals who contributed valuable expertise and guidance to the progress of the project. At the University of Maryland, we appreciate the inputs of Stephan Tubene, Agricultural Economist, Coordinator of the Small Farm Institute, and State Coordinator of Cooperative State Research, Education, and Extension Service (CSREES) – USDA Small Farm Programs. We also recognize the valuable contributions from Rutgers Food Innovation Center (FIC) and Interregional Research Project No. 4 (IR-4) and most notably, the respective marketing and crop expertise of Diane D. Holtaway, Associate Director and Hong Chen, Chair - International Crop Grouping Consulting Committee. These university partners made significant contributions in the initial consumer survey development, specifically in the ethnic crop identification and selection process. We acknowledge the Language Institute at Rutgers and, in particular, Professors R. Van Ness Simmons and Phyllis Zatlin for their assistance in securing translators from their respective Asian and Spanish language departments to prepare bilingual versions of the ethnic consumer surveys. Morris Gbolo, Brian Hulme, and Vivian Quinn of Rutgers Cooperative Extension are recognized and appreciated for their field trial management. We also thank Drs. Chung Park and Qing-Li Wu of Rutgers Plant Biology and Pathology for their valuable assistance and support relative to Asian ethnic crops. This project was supported by the National Research Initiative (NRI) of the Cooperative State Research, Education and Extension Service, United States Department of Agriculture (USDA), Award # 2005-35618-15735. The opinions expressed in the article are those of the authors and do not necessarily reflect official positions or policies of the USDA, NRI,, Rutgers University, University of Florida, or University of Massachusetts.
THE INHIBITION OF PERIPROSTHETIC BONE RESORPTION IN VITRO. (2002)

Aseptic loosening is currently the leading cause of failure of total hip arthroplasty. The aetiology of periprosthetic bone resorption is currently under intense investigation. Wear particles are produced from the articulating surface of the femoral and acetabular components. These particles gain access to the bone-cement interface where they are phagocytosed by macrophages. Particle stimulated macrophages differentiate into bone resorping osteoclasts. This leads to periprosthetic bone resorption and subsequent implant loosening. Nuclear factor kappa B (NFκB) is a transcription factor known to be activated by pathogenic stimuli in a variety of cells. The activation of NFkB would appear to be the primary event in the activation of particle stimulated macrophages in the periprosthetic membrane. NFκB subsequently causes a cascade of events leading to the release of bone resorbing cytokines, namely interleukin-6 (IL-6) and tumour necrosis factor α (TNFα). The aim of our study was to ascertain if bone resorption could be prevented in vitro by the addition of PDTC, an NFkB inhibitor to particle stimulated macrophages. Human monocytes were isolated and cultured from healthy volunteers. The monocyte/macrophage cell line was differentiated into osteoclasts by the addition of alumina particles and allowed to adhere onto bone slices. The NFkB inhibitor, PDTC, has added to the cultured osteoclasts. Bone resorption was analysed by counting the number of resorption pits in each bone slice. The addition of PDTC to stimulated macrophages reduced the number of resorption pits by greater than 40% compared to control. This is a unique and promising finding that may offer a future therapeutic strategy for the prevention of periprosthetic bone resorption and therefore aseptic loosening in total hip arthoplasty.
Two-Level Factorial Study of the Rheology and Foaming of Bromobutyl Rubber Solutions (1991)

Abstract The rheology and foaming properties of BIIR coating slurries were studied. Two-level three-factorial analyses showed that solids content had the main influence on apparent viscosity, and foaming was less persistent at higher concentration of hydrated silica. Bentonite, on the other hand, had no statistically significant contribution.
Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers (2021)

Clonal hematopoiesis of indeterminate potential (CHIP) is characterized by detectable hematopoietic-associated gene mutations in a person without evidence of hematologic malignancy. We sought to identify additional cancer-presenting mutations useable for CHIP detection by performing a data mining analysis of 48 somatic mutation studies reporting mutations at diagnoses of 7,430 adult and pediatric patients with hematologic malignancies. Following extraction of 20,141 protein-altering mutations, we identified 434 significantly recurrent mutation hotspots, 364 of which occurred at loci confidently assessable for CHIP. We then performed an additional large-scale analysis of whole exome sequencing data from 4,538 persons belonging to three non-cancer cohorts for clonal mutations. We found the combined cohort prevalence of CHIP with mutations identical to those reported at blood cancer mutation hotspots to be 1.8%, and that some of these CHIP mutations occurred in children. Our findings may help to improve CHIP detection and pre-cancer surveillance for both children and adults.
Millimeter Wave Technology for Moon and Mars Exploration (2008)

The new vision for the moon exploration calls for a return to the moon in a series of missions that start with robotic. Many of the large-scale features, such as steep crater walls and large boulders, are insurmountable obstacles to the rover. Thus, the development of systems for the guidance of rovers is a crucial issue. In this paper a radio frequency (RF) multifunctional payload for the support of rover operations on the lunar surface is presented. Since the dimensions of Radio-Frequency devices is strictly correlated with the wavelength, the use of higher frequency allows to obtain payload with small dimensions. The instruments proposed in this paper operates in the W-band (75-110 GHz). After an introduction explaining the reasons that could make such a payload successful, the navigation requirements are evaluated on the basis of the expected rover characteristics. Then, the payload functional scheme is presented and its performance and physical features are shown.
Studies on Actinomycetes Isolated from Plant Leaves. (1998)

Isolation method for the purpose of obtaining kinds of actinomycetes in plant leaves has been devised. All isolates were classified into genus based on their taxonomical characteristics. They included not only the genus Streptomyces but also the rare genera. In particular, strains belonging to the genus Microbispora represented more than 50% of the total share belonging to the rare isolates1). Two strains of isolates produced new herbicidal antibiotics, herbicidin H produced by Streptomyces sp. SANK 63997 and γ-glutamylmethionine sulfoximine by Microbispora sp. SANK 62597.
Assessment of the epi-pericardial fibrotic substrate by collagen-targeted probes (2022)

The identification of the fibrotic arrhythmogenic substrate as a means of improving the diagnosis and prediction of atrial fibrillation has been a focus of research for many years. The relationship between the degree of atrial fibrosis as a major component of atrial cardiomyopathy and the recurrence of arrhythmia after AF ablation can correlate. While the focus in identification and characterisation of this substrate has been centred on the atrial wall and the evaluation of atrial scar and extracellular matrix (ECM) expansion by late gadolinium-enhancement (LGE) on cardiac magnetic resonance imaging (CMRI), LGE cannot visualise diffuse fibrosis and diffuse extravasation of gadolinium. The atrial pericardium is a fine avascular fibrous membranous sac that encloses the atrial wall, which can undergo remodelling leading to atrial disease and AF. Nevertheless, little attention has been given to the detection of its fibrocalcification, impact on arrhythmogenesis and, most importantly, on the potential prothrombotic role of epi-pericardial remodelling in generation of emboli. We have recently reported that tracers against collagen I and IV can provide a direct assessment of the ECM, and thus can estimate fibrotic burden with high sensitivity. Here, we show the ability of these optical tracers to identify epi-pericardial fibrosis, as well as to demonstrate subtle interstitial fibrosis of the atrial wall in a mouse model of beta-2-adrenergic receptor (β<sub>2</sub>-AR) cardiac overexpression.
Organic Light-Emitting Electrochemical Cells Based on Polyfluorene. Investigation of the Failure Modes (2001)

The discovery of organic light-emitting electrochemical cells (OLECs) has opened new directions for organic light-emitting devices based on luminescent conjugated polymers. However, such systems face two major problems: slow turn-on speed and short lifetime. If the p-n time formation can be efficiently reduced by increasing the ionic conductivity of the active layer by simply adding salt-laden poly(ethylene oxide), especially when the salt is fully dissociated, short lifetimes remains a key issue. A study of the decay of the electroluminescence intensity vs. current ratio as a function of time is representative of the quantum efficiency and can be compared with the evolution of the cyclic voltammograms, representative of the system electroactivity. We report that the main degradation process involved in the decrease of the light emission intensity during device operation is based on a current-driven degradation of the semiconducting polymer, mainly a loss of capacity on the "n" side. Possibly this is associated with an irreversible reduction of the anions from the added salt. © 2001 The Electrochemical Society. All rights reserved.