gebhart/patrepeval huggingface dataset:
MyDeepWeb: An Integration Service for Your OWN Deep Web Data (2011)

Current Web users usually have their own files, work documents, communications and personal contacts distributed in the storage systems of many widely-used Internet services(e.g. Google Docs, Gmail, Facebook, Zoho). Therefore, they face the challenge of being not able to have an integrated view for their related data objects (e.g. mails, pics, docs, contacts). Recently, most of the major Internet services provide standard APIs that allow developing software applications that can read and write data from their underlying data store after providing the credential access information of registered accounts. The MyDeepWeb system is designed to let the Web users interact with their Internet services normally while, behind the scene, the information of their objects will be extracted, consolidated, linked and then populated into a single private cloud-based data store where the user can have integrated access to their data objects from anywhere through multiple devices.
High-Dimensional Cytometry Dissects Immunological Fingerprints of Idiopathic Inflammatory Myopathies (2022)

Chronic inflammation of skeletal muscle is the common feature of idiopathic inflammatory myopathies (IIM). Given the rarity of the disease and potential difficulty of routinely obtaining target tissue, i.e., standardized skeletal muscle, our understanding of immune signatures of the IIM spectrum remains incomplete. Further insight into the immune topography of IIM is needed to determine specific treatment targets according to clinical and immunological phenotypes. Thus, we used high-dimensional flow cytometry to investigate the immune phenotypes of anti-synthetase syndrome (ASyS), dermatomyositis (DM) and inclusion-body myositis (IBM) patients as representative entities of the IIM spectrum and compared them to healthy controls. We studied the CD8, CD4 and B cell compartments in the blood aiming to provide a contemporary overview of the immune topography of the IIM spectrum. ASyS was characterized by altered CD4 composition and expanded T follicular helper cells supporting B cell-mediated autoimmunity. For DM, unsupervised clustering identified expansion of distinct B cell subtypes highly expressing immunoglobulin G4 (IgG4) and CD38. Lastly, terminally differentiated, cytotoxic CD8 T cells distinguish IBM from other IIM. Interestingly, these terminally differentiated CD8 T cells highly expressed the integrin CD18 mediating cellular adhesion and infiltration. The distinct immune cell topography of IIM might provide the framework for targeted treatment approaches potentially improving therapeutic outcomes.
Transition and Stability of Copolymer Adsorption Morphologies on the Surface of Carbon Nanotubes and Implications on Their Dispersion (2014)

In this study, the adsorption morphologies as well as stability and transitions of a commercial dispersant copolymer (BYK 9076) on the surface of multiwalled carbon nanotubes (MWCNTs) were studied using Fourier transform infrared and UV-vis spectroscopy, dynamic light scattering, and electron microscopy techniques. The results show that the dispersion of carbon nanotubes in ethanol does not increase continuously with increasing copolymer/CNT ratio, which is correlated with the adsorption morphologies of the copolymer on the CNT surface. At a ratio of copolymer/CNT below 0.5, the morphology is random, shifting to a hemimicelle structure at a ratio from 0.5 to 1.0 while at ratios above 1.0, a cylindrical pattern is seen. The hemimicelle morphology is able to prevent the agglomeration of CNTs when the CNT concentration increases to 8.7 mg/mL, while cylindrical morphology is more efficient and stable to provide dispersion of CNTs at higher concentrations of CNTs.
PAR3 acts as a molecular organizer to define the apical domain of chick neuroepithelial cells (2006)

Neural progenitors in the vertebrate nervous system are fully polarized epithelial cells, with intercellular junctions at the apical region. These progenitor cells remain within the neuroepithelium throughout neurogenesis, and will ultimately give rise to all the neurons in the mature nervous system. We have addressed the role of the PAR polarity complex in vertebrate neuroepithelial polarity and show that PAR3 functions as the initial scaffold to assemble and organize the PAR complex at the apical region of neuroepithelial cells, coordinating also the recruitment of additional polarity complexes and junction-associated proteins to the same region, while restricting other polarity proteins to the basolateral membrane. We propose that PAR3 acts as a molecular organizer to connect the acquisition of apico-basal polarity with the positioning and formation of junctional structures in neuroepithelial cells, a function of upmost importance for the morphogenesis of embryonic neural tissue and the process of neurogenesis.
Atropisomerization Barriers of Configurationally Unstable Biaryl Compounds, Useful Substrates for Atroposelective Conversions to Axially Chiral Biaryls (2000)

Configurationally unstable biaryl lactones of type (M)-1 ⇌ (P)-1 and ring-opened 2-acyl-2‘-hydroxy biaryl compounds of type (M)-4 ⇌ (P)-4 are versatile precursors for the atroposelective preparation of axially chiral biaryls. The activation barriers of their atropisomerization process, which constitutes a fundamental precondition for the dynamic kinetic resolution, were determined by dynamic NMR spectroscopy for rapid processes and by HPLC-monitored racemization of enantiomerically enriched material for smaller interconversion rates. For the lactones, the free activation energies ΔG⧧298 increase with the steric demand of the substituent R ortho to the biaryl axis in the series H < OMe (t1/2 ≈ ms) < Me (t1/2 ≈ s) < Et < i-Pr (t1/2 ≈ min) < t-Bu (t1/2 ≈ d). The formally ring-opened 2-acyl-2‘-hydroxy biaryls, which interconvert via the lactol isomers 5 as the cyclic (and thus configurationally less stable) intermediates, have a significantly slower atropisomerization rate as a result of the high loss in activation entropy ΔS⧧ as a consequence of the required intermediate ring closure 4 → 5.
Frustrated Flexibility in Metal-Organic Frameworks (2020)

&lt;div&gt;&lt;div&gt;&lt;div&gt;&lt;p&gt;Stimuli-responsive flexible metal-organic frameworks (MOFs) remain at the forefront of porous materials research due to their enormous potential for various technological applications. Here, we introduce the concept of frustrated flexibility in MOFs, which arises from an incompatibility of intra-framework dispersion forces with the geometrical constraints of the inorganic building units. Controlled by appropriate linker functionalization with dispersion energy donating alkoxy groups, this approach results in a series of MOFs exhibiting a new type of guest- and temperature-responsive structural flexibility characterized by reversible loss and recovery of crystalline order under full retention of framework connectivity and topology. The stimuli-dependent phase change of the frustrated MOFs involves non-correlated deformations of their inorganic building unit, as probed by a combination of global and local structure techniques together with computer simulations. Frustrated flexibility may be a common phenomenon in MOF structures, which are commonly regarded as rigid, and thus may be of crucial importance for the performance of these materials in various applications.&lt;/p&gt;&lt;/div&gt;&lt;/div&gt;&lt;/div&gt;
Abstract 11283: Induction of Interferon-Stimulated Gene 15 by Pressure Overload Facilitates Adverse Ventricular Remodeling (2022)

Introduction: Inflammation promotes adverse ventricular remodeling, a common antecedent of heart failure. Here, we set out to determine how cardiomyocytes respond to accumulating inflammatory cells within the remodeling heart and how this response, in turn, affects heart function. Methods: Experiments were performed in mouse and rat models of pressure overload, cultured mouse and human cardiomyocytes and human heart failure tissue. Results: CCR2+ monocyte-derived macrophages from Ccr2 gfp/+ mice accumulated early in mouse hearts after transverse aortic constriction (TAC) and Ccr2 knockout attenuated cardiac function decline (ejection fraction, fractional shortening, cardiac output and stroke volume). Cardiomyocyte RNA sequencing revealed that the secretome of CCR2+ cells isolated from TAC hearts induced an interferon response in cardiomyocytes, characterized by upregulation of interferon-stimulated gene 15 (ISG15), which post-translationally modifies actively translated proteins through a process termed ISGylation. ISG15 upregulation or protein ISGylation were also observed in the hearts of mice infused with angiotensin II, uninephrectomized rats treated with DOCA-salt, rats after pulmonary artery banding; mouse and human cardiomyocytes exposed to recombinant interferons; and ventricular tissue of humans with non-ischemic cardiomyopathy. ISG15 accumulated at, or close to, cardiomyocyte intercalated discs and Nano LC-MS/MS, co-immunoprecipitation and co-localization experiments identified the myofibrillar protein filamin-C to be an ISGylation target at these sites. Lastly, knockout of Isg15 attenuated cardiac function decline in mice following TAC, accompanied by a transcriptional profile indicative of preserved cardiac energetics. Conclusions: Collectively, these studies reveal that ISG15 induction is a characteristic of non-ischemic ventricular remodeling and they identify protein ISGylation as an inflammation-induced post-translational modification that may contribute to heart failure development. Strategies that prevent the ISGylation of cardiomyocyte proteins occurring during ventricular remodeling may improve heart failure outcomes.
Nanostructured cathode materials for alkaline and lithium rechargeable batteries (1999)

US Nanocorp, Inc. is pioneering the synthesis of nanostructured active battery materials by a novel aqueous solution reaction (ASR) process that is inherently low cost and scalable to volume production. Strategies for the production of high energy content battery electrodes are discussed. Focus areas include Ni(OH)/sub 2/, both pure and Al-doped and /spl gamma/-MnO/sub 2/ for rechargeable alkaline batteries as well as the hollandite form of /spl alpha/-MnO/sub 2/ for intercalation of lithium. The synthesis of nanostructured pyrite as a feedstock powder for thermal spray to rapidly deposit FeS/sub 2/ thin film electrodes for thermal batteries is also discussed.
Rapid detection of ESBL-producing Enterobacteriaceae from blood cultures: A prospective study (2014)

Background: Enterobacterial strains producing clavulanic-acid inhibited extended-spectrum beta-lactamases (ESBLs) are increasingly reported worldwide. The rapid detection of ESBL-producing Enterobacteriaceae responsible for bacteremia is of utmost importance since their successful treatment depends on prompt administration of the appropriate antimicrobial agents. The ESBL NDP test has been evaluated here prospectively to detect ESBL-producing Enterobacteriaceae directly from blood cultures. Methods & Materials: From November 2012 to May 2013, the ESBL NDP test, a rapid chromogenic test based on detection of cefotaxime hydrolysis, was performed with 96 blood cultures positive for Gram negatives. Results of the ESBL NDP test, obtained in less than 30 min, were compared to those obtained with the double disk diffusion technique. All ESBLs were then characterized at the molecular level. Identification of the Gram-negative bacteria was also performed directly on positive blood cultures using MALDI-TOF technology, and confirmed by a biochemical identification. Results: Eighteen blood cultures infected with ESBL-producing Enterobacteriaceae (15 CTX-M producing E. coli and 3 CTX-M producing K. pneumoniae) were correctly detected, whereas 78 infected by non-ESBL-producing isolates gave negative results with the ESBL NDP test. Results of the ESBL NDP test were 100% correlated with those of the double disk-diffusion method with the main advantage that they were obtained in less than 30 min directly from the clinical sample versus an additive 24 h time of incubation for the double disk-diffusion method. Conclusion: Using the ESBL NDP test, identification of an ESBL producer responsible for a bacteremia can be reduced from 24-48 hours to 30 min with 100% sensibility, 100% specificity, 100% negative predictive value and 100% positive predictive value. Since the successful treatment of septicemia depends on prompt administration of the appropriate antimicrobial agents, use of the ESBL NDP test directly from positive blood cultures may significantly improve the outcome of infected patients.
In situ resonance Raman spectroscopic investigation of the tetrathiafulvalene-tetracyanoquinodimethan electrode surface (1979)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTIn situ resonance Raman spectroscopic investigation of the tetrathiafulvalene-tetracyanoquinodimethan electrode surfaceWilliam L. Wallace, Calvin D. Jaeger, and Allen J. BardCite this: J. Am. Chem. Soc. 1979, 101, 17, 4840–4843Publication Date (Print):August 1, 1979Publication History Published online1 May 2002Published inissue 1 August 1979https://pubs.acs.org/doi/10.1021/ja00511a010https://doi.org/10.1021/ja00511a010research-articleACS PublicationsRequest reuse permissionsArticle Views159Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Simultaneous multislice inversion contrast imaging using power independent of the number of slices (PINS) and delays alternating with nutation for tailored excitation (DANTE) radio frequency pulses (2012)

A method for simultaneous multislice (SMS) inversion contrast imaging is presented using a combination of the delays alternating with nutation for tailored excitation (DANTE) and the power independent of the number of slices (PINS) techniques. In SMS imaging, simultaneously excited slices result in an aliased image that is disentangled using parallel imaging reconstruction techniques. At high-magnetic field strengths, the peak amplitude and specific absorption rate of conventional (summed) SMS radio frequency pulses can be prohibitively high. Using the PINS approach, specific absorption rate is independent of the number of slices allowing high SMS acceleration factors even at high fields. Using DANTE, adiabatic SMS radio frequency pulses can be created to be combined with PINS. This allows 2D imaging protocols that employ adiabatic pulses to also reap the benefits of low specific absorption rate SMS acceleration. As a proof-of-concept, simulations and measurements using hyperbolic secant inversion pulses are shown.
On Small Terminal MIMO Antennas, Harmonizing Characteristic Modes With Ground Plane Geometry (2015)

multiple input-multiple output (MIMO) antenna systems are defined by fundamental figure of merits (FoM), such as branch imbalance, total efficiency, mean effective gain (MEG), and the correlation coefficient. Those FoM requirements are challenging, specially when applied to electrically small mobile devices, i.e., smart-phones, due to the form factor-reduced dimensions and multiplicity of adjacent frequency bands of operation. Uncorrelated antennas are especially important for MIMO antenna systems; other than few exceptional cases, the reduction of magnitude of complex correlation coefficient will increase the system capacity and data throughput. This work proposes an MIMO antenna system for mobile terminals, based on a realistic form factor and packaging implementation, with a very low magnitude of the complex correlation coefficient and an impressive isolation. An isolation better than 20 dB has been achieved using a folded monopole and a commonly adopted planar inverted F antenna (PIFA) on a platform with a very small form factor (100 × 50 × 10 mm). The proposed implementation is based on the synergy of two known techniques that consists in the: 1) reference ground plane geometry manipulation and 2) in the application of the characteristic mode theory to obtain orthogonal radiation modes. Since MIMO antenna systems at frequencies higher than 1.7 GHz are naturally proper isolated and decorreleated, this work demonstrates the proposed antenna topology enabling higher isolation and uncorrelated antenna system at 750 MHz, which is more difficult to achieve in form factors smaller than 1λ, while maintaining high total efficiency and adequate gain imbalance. In this paper, a simulation model and prototype (1/4λ long) measurement results are presented, demonstrating the implementation feasibility of such antenna system in realistic mobile device embodiment.
Une balade au sein de la revue de la Société d’histoire de la pharmacie : cent ans de recherche en matière d’histoire de la pharmacie (2013)

Une balade au sein de la revue de la Société d’histoire de la pharmacie : cent ans de recherche en matière d’histoire de la pharmacie – La Revue d’histoire de la pharmacie, d’abord sous le nom de Bulletin de la Société d’histoire de la pharmacie, a rassemblé depuis cent ans une masse d’informations, de recherches, de connaissances, qui ont permis de mieux analyser l’origine de cette profession, les aspects fondamentaux qui la caractérisent et qui la différencient des autres professions de santé. La Revue a également été l’occasion d’étudier les ouvrages de référence et un grand nombre de pharmaciens, médecins et chimistes qui ont contribué à écrire cette histoire de la pharmacie des origines à nos jours, ainsi que tous ceux qui, de près ou de loin, ont été présents dans l’environnement du pharmacien. Cet ensemble unique a conduit la base de données Persée à numériser toute la Revue depuis son origine en 1913, pour la rendre accessible au plus grand nombre et permettre de partir d’une base très solide pour poursuivre la recherche dans ce domaine. Ce travail est bien sûr utile pour les historiens, mais il est aussi un socle pour mettre en valeur les qualités et les valeurs attendues pour cette profession indispensable à l’amélioration et au maintien de la santé publique, et pour les professionnels qui la servent. L’objet de la présente étude est de montrer par quelques exemples la richesse de cette base d’informations sur l’histoire de la pharmacie.
The oleaginous yeast <i>Starmerella bombicola</i> reveals limitations of <i>Saccharomyces cerevisiae</i> as a model for fatty acid transport studies (2022)

Saccharomyces cerevisiae is the model organism to most yeast researchers, and information obtained from its physiology is generally extrapolated to other yeasts. Studies on fatty acid transport in S. cerevisiae are based on the expression of both native fatty acid export genes as well as heterologous proteins. Starmerella bombicola, on the other hand, is an oleaginous yeast of industrial relevance but its fatty acid transport mechanisms are unknown. In this study, we attempt to use existing knowledge from S. cerevisiae to study fatty acid transport in S. bombicola, but the obtained results differ from those observed in S. cerevisiae. First, we observed that deletion of SbPRY1 in S. bombicola leads to higher fatty acid export, the opposite effect to the one previously observed for the Pry homologues in S. cerevisiae. Second, following reports that human FATP1 could export fatty acids and alcohols in S. cerevisiae, we expressed FATP1 in a fatty acid-accumulating S. bombicola strain. However, FATP1 reduced fatty acid export in S. bombicola, most likely due to its acyl-CoA synthetase activity. These results not only advance knowledge on fatty acid physiology of S. bombicola, but also improve our understanding of S. cerevisiae and its limitations as a model organism.
Viral carcinogenesis (2019)

Between 20 and 30% of human cancers are caused by infectious agents. These can be multicellular parasites, bacteria, or viruses. Whereas bacteria and parasites cause cancer by indirect mechanisms, such as inflammation and immune deregulation, viruses infect human cells directly and initiate molecular changes that lead to uncontrolled proliferation. Both DNA and RNA viruses, such as retroviruses, can cause cancer; however, the ability to promote cancer is a by-product of viral evolution and a low frequency event, often the result of faulty virus replication. Most human oncogenes, such as <italic>MYC, SRC, RAS</italic>, were first discovered because they had been pirated by retroviruses. The function of key human tumour suppressor proteins, such as RB and TP53, were identified because they bind to and are inactivated by DNA tumour viruses. Because viruses are foreign, vaccines can be devised that target them. More recently it has become possible to prevent two types of cancer caused by viruses—cervical cancer caused by human papillomavirus (HPV) and hepatocarcinoma caused by hepatitis B virus (HBV)—by preventing the initial infection using vaccination. Study of the relationship between infective agents and cancer has therefore achieved two main goals: to unravel basic mechanisms of carcinogenesis and to make some cancers preventable.
ENERGY-AWARE RADIO LINK CONTROL FOR OFDM-BASED WLAN (2004)

Next generation wireless local area network (WLAN) terminals have to cope with increasing performance requirements while energy budgets are more and more constrained by portability. Next to low power circuit and architecture design, system-level power management is a key technology to fill this gap. Recently, radio link control techniques have been proposed, not only as a way to maximize performance but also to reach energy awareness. Transmit rate and power are adapted to meet exactly the user requirements while minimizing the average power consumption. However, schemes proposed so far do not exploit the characteristics of the specific modulation scheme considered in most recent WLAN standards: orthogonal frequency division multiplexing (OFDM). In this paper, we design a practical energy aware radio link control scheme, optimized for OFDM transceivers and compatible with current standards. Simulation results depict up to 80% transceiver power reduction when compared with throughput maximizing schemes.