gebhart/patrepeval huggingface dataset:
Nonlinear Digital Back Propagation compensator for coherent optical OFDM based on factorizing the Volterra Series Transfer Function (2013)

We introduce an efficient and accurate nonlinear compensator (NLC) for digital back-propagation (DBP) of coherent optical OFDM receivers, based on a factorization procedure for the Volterra Series Transfer Function (VSTF) with 3N degrees of freedom for N frequency samples. The O(N2) nonlinear compensation complexity of generic Volterra evaluation (normalized per-subcarrier) is reduced to 28 + 6logN. Our analysis and simulations indicate that this NLC system outperforms previous VSTF-based non-linear compensation methods. Compared to a most recent VSTF-based method, the new method incurs 52% extra computational complexity in return for improved nonlinear tolerance of ~2 dB for the particular analyzed link.
Analysis of the electromagnetic acoustic noise and vibrations of a high-speed brushless DC motor (2016)

In this paper, the acoustic noise and vibrations due to Maxwell forces of a 4-pole, 12-slot, high-speed brushless DC motor (BLDC) is analysed up to 90 kRPM. The harmonic magnetic forces present in the machine are first analytically characterized, and validated with numerical simulations using MANATEE® electromagnetic and vibro-acoustic software. The effects of rotor vibrations due to bearing faults, pole displacements and eccentricities are considered. Finally, some complete experimental measurements relying on “spatiogram” techniques are run to characterize the vibration waves (wavenumber and frequency) involved in acoustic noise generation. These results are compared to simulations and it is demonstrated that the observed high acoustic noise is due to machine imperfections creating harmonic forces exciting the bending mode of the shaft and the stator elliptical mode.
Power Optimal Buffered Clock Tree Design (1995)

We propose a new problem formulation for low power clock network design that takes rise time constraints imposed by the design into account. We evaluate the utility of inserting buffers into the clock route for satisfying rise time constraints and for minimizing the area of the clock net. In particular, we show that the classical H-tree is sub-optimal in terms of both area and power dissipation when buffers may be inserted into the tree. We show that the power minimization problem is NP-hard and propose a greedy heuristic for power-optimal clock network design that utilizes the opportunities provided by buffer insertion. Our algorithm inserts buffers and designs the topology simultaneously. The results we obtain on benchmarks are significantly better than previous approaches in terms of power dissipation, wire length, rise times and buffer area. Power dissipation is typically reduced by a factor of two, rise times are four times better and buffer area requirements are an order of magnitude smaller.
P3‐075: Development of a targeted proteomic multiplex CSF assay for neurodegenerative markers (2015)

Targeted proteomics of cerebrospinal fluid (CSF) has potential utility for validating novel biomarkers in Alzheimer's disease (AD). We developed a multiplex mass spectrometry assay of proteins, thought to be of interest in neurodegeneration, performing an exploratory analysis for proteins distinguishing individuals with AD and non-AD CSF signatures. CSF samples were prospectively collected according to a standard operating procedure from individuals with cognitive concerns and healthy controls, across two sites. Subjects were classified according to CSF biomarker profile determined using commercially available ELISAs for Aβ1-42, total tau (T-tau) and phospho-tau 181 (P-tau) as a surrogate marker for amyloid status. Subjects were defined as having a positive AD CSF profile if CSF Tau/Aβ1-42 ratio ≥1 and ptau ≥63 and a negative profile if tau/Aβ1-42 ratio <1 and P-tau<63, irrespective of clinical diagnosis. Quantotypic peptides were selected for a panel of 47 proteins. Internal standards consisting of heavy labelled peptides were added to 100ul of CSF, freeze dried and in-solution trypsin digested. Digested CSF was run on a Waters Acquity UPLC over a 10min acetonitrile gradient. Peptides were quantitated on a Waters Xevo TQ-S triple quadrupole mass spectrometer. Peptides were ratioed to internal standards and absolute quantative values obtained from standard curves. Significance was determined using unpaired t-test for normally distributed data and Wilcoxin signed-rank test for non-normal data, with Bonferroni correction to account for multiple comparisons. We identified eight proteins showing significant (p≤0.001) differences between individuals with positive/negative CSF profiles independent of clinical diagnosis. These included proteins previously implicated in AD pathogenesis (e.g. ApoE, YKL-40, cystatin C and osteopontin) but also others to our knowledge not previously associated (e.g. Glutathione-S-transferase Omega-1 and CNDP1) (Table). We have identified eight proteins, which may have relevance in AD pathophysiology using this technique. Targeted proteomics can provide a cost effective high-throughput multiplexed platform for streamlining the validation and stratification of biomarkers in neurodegeneration using small quantities of CSF.
The Golden Age of Imaging (2008)

Imaging research, development, and applications are growing at an astounding rate, and image-processing researchers can take credit for having created much of the enabling technologies that have fueled this growth. The development of image and video coding standards, such as JPEG and MPEG, has enabled the web as a center for commerce and entertainment. Ubiquitous technologies, such as Direct TV, DVDs, BlueRay, and TiVo, depend on these standards; streaming Internet video services, like Tunes' recently announced movie rental feature, are well on their way to replacing traditional analog broadcast video. Other consumer products, such as home printers, digital cameras, and mobile video devices, have each been a major disruptive product enabled by fundamental innovation from image-processing researchers.
A Direct Entry to Carbasugars: Asymmetric Synthesis of 1‐epi‐(+)‐MK7607. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Synthesis and characterization of a distyrylbenzene derivative for use in organic electroluminescent devices (1995)

New materials have been synthesized by attaching long alkyl chains to the basic distyrylbenzene chromophore. The most promising material, 4,4″-di(dodecyloxy)distyrylbenzene, has been characterized, and vacuum-deposited films have been used as the emitting layer in organic electroluminescent (EL) cells. Bright blue emission, with an emission maximum at 482 nm and a maximum luminance of over 50 cd m–2, has been obtained from such devices. When deposited as Langmuir–Blodgett (LB) films, it is hoped that these materials will provide interesting new insight into the effect of molecular orientation in organic EL devices.
A New Algorithm for Matched Case-Control Studies with Applications to Additive Models (1988)

Logistic models are commonly used to analyze matched case-control data. The standard analysis requires the computation of conditional maximum likelihood estimates. We propose a simple algorithm that uses a diagonal approximation for the (non-diagonal) weight matrix deriving from the Newton-Raphson method. The primary purpose of the new algorithm is to exploit iterative reweighted least-squares procedures for fitting general additive rather than simple linear structure.
Caracterização microestrutural da argila expandida para aplicação como agregado em concreto estrutural leve (2006)

A utilização da argila expandida como agregado graúdo é economicamente viável na fabricação de concretos devido à redução da massa especifica que estes agregados proporcionam, minimizando os carregamentos atuantes nas estruturas. O objetivo deste trabalho é caracterizar a microestrutura do agregado leve de argila expandida visando sua utilização na fabricação de concretos. Na caracterização física da argila expandida foram avaliadas a massa unitária, a granulometria e a absorção de água por imersão total do agregado. Na caracterização microestrutural, foram realizadas análise química, microscopia eletrônica de varredura, difração de raios X e porosimetria por intrusão de mercúrio. A argila expandida apresentou granulometria entre as britas com graduação 0 e 1, e apresentou alta absorção de água devido à elevada porosidade deste agregado. Na análise de difração de raios X evidenciou-se a presença de sílica na forma mineral de alfa-quartzo, silicato de magnésio e óxido de alumínio e magnésio.
Enzootic Bovine Rotavirus is Not a Source of Infection in Panamanian Cattle Ranchers and Their Families (1986)

Vaccination of humans against rotavirus (RV) diarrhea may be accomplished by oral immunization with attenuated animal strains known to be antigenically very similar to human strains. To define better the degree of infectivity in nature of these animal strains for humans, we conducted surveillance for RV infection/diarrhea in 180 farm workers, their 161 family contacts, and the 566 animals (512 cattle, 35 pigs, and 19 sheep) on 14 farms in rural Panama. No correlation between the high infection rates in farm workers (72%) and their family contacts (78%) and in cattle (56%) could be demonstrated. Heads of families with four or more children with RV infection experienced a twofold greater rate of RV infection compared with heads of families of similar size without RV infection. Despite the close similarity between human and bovine RV, in Panama intrafamilial (particularly child-to-child or child-to-parent) rather than interspecies transmission appeared to be the most important route for the spread of this highly infectious virus.
Predicting Reactivity and Stereoselectivity in the Nazarov Reaction: A Combined Computational and Experimental Study (2008)

The Nazarov reaction of pentadienyl cations generated by protonation of either dienones or alkoxytrienes has been examined in detail both experimentally and by DFT calculations. In particular, calculations at the B3LYP/6-311G** level of theory accurately predicted, and accounted for, the outcome of the Brønsted acid catalyzed electrocyclization of 4pi-electron systems in which one of the double bonds involved in the process was embedded in N- and S-heterocyclic rings. Calculations showed that both heteroatoms are capable of accelerating the ring closure by stabilizing the partial positive charge which develops at C-6 (C-2) in the transition state, with S-heterocyclic derivatives being more reactive than the corresponding N-containing compounds. In general, pentadienyl cations generated by protonation of alkoxytrienes were expected to react faster than those obtained by protonation of the corresponding dienones, as the latter were stabilized by a hydrogen bond. The presence of a substituent on the heterocyclic ring significantly affects the stereoselectivity (torquoselectivity) only in the case of the N-heterocyclic derivatives, in which a 2-alkyl group is axially oriented, providing the cis-2,5-disubstituted isomer only. Instead, with substituted S-heterocyclic compounds, the anticipated torquoselectivity was very low and, in fact, a 3:1 diastereomeric mixture between the trans and cis products was experimentally found after ring closure. For this study, the synthesis of the appropriate N- and S-containing dienones and alkoxytrienes was realized to evaluate the predictivity power of the DFT computations, which was very good in all of the cases examined, both in terms of reactivity and stereoselectivity. The consistency observed between computational and experimental results, therefore, shows the usefulness of DFT calculations at the B3LYP/6-311G** level of theory as a robust instrument for the prediction of reactivity and stereoselectivity in the Nazarov electrocyclic reaction.
Doenças pós-colheita em laranja 'Pêra' produzida em sistema orgânico econvencional e resistência de Penicillium digitatum a fungicidas Postharvest diseases in 'Pêra' orange cultivated in organic and conventional systems and resistance of Penicillium digitatum to fungicides (2013)

As doenças pós-colheita podem ser responsáveis por perdas tiabendazol (10 mg.L-1) e imazalil (1 mg.L-1). Frutos tratados com significativas ao citricultor. Este trabalho objetivou: a) caracterizar imazalil apresentaram a menor incidência (5,4%) de doenças pós-as doenças pós-colheita em laranjas 'Pêra' provenientes de cultivo colheita, enquanto que frutos provenientes de pomares orgânicos orgânico e convencional, com ou sem tratamento pós-colheita com apresentaram a maior incidência (25,2%). As principais doenças pósimazalil, comercializadas na CEAGESP; e b) detectar a presença de colheita foram o bolor verde em frutos produzidos em sistema isolados de Penicillium digitatum resistentes a fungicidas em frutos convencional e as podridões pedunculares de lasiodiplodia e de com bolor verde. Frutos permaneceram em câmara úmida por 24 phomopsis em frutos orgânicos. A frequência relativa de isolados de horas, e por mais 13 dias a 25 ºC e 85% de UR. A incidência de P. digitatum resistentes ao fungicida tiabendazol foi menor em frutos doenças foi avaliada visualmente a cada 2-3 dias. A presença de P. orgânicos, enquanto a frequência de isolados de P. digitatum resistentes digitatum resistente a fungicidas foi avaliada em função do crescimento ao imazalil e à mistura tiabendazol+imazalil foi maior em frutos que micelial em meio batata-dextrose-ágar acrescido dos fungicidas receberam tratamento pós-colheita com imazalil.&lt;br&gt;Postharvest diseases may be responsible for significant losses to added of the fungicides thiabendazole (10 mg.L-1) and imazalil (1 citrus growers. This study aimed to: a) characterize the postharvest mg.L-1). Fruits treated with imazalil had lower incidence (5.4%) of diseases in 'Pêra' oranges from organic and conventional crops, with postharvest diseases, while fruits from organic crop had the highest or without postharvest treatment with imazalil, marketed in incidence (25.2%). The main postharvest diseases were green mold CEAGESP; and b) detect the presence of Penicillium digitatum isolates in fruits produced in the conventional system and Lasiodiplodia and resistant to fungicides in fruits with green mold. Fruits were kept in a Phomopsis stem-end rot in organic fruits. The relative frequency of humid chamber for 24 hours and for additional 13 days at 25 ºC and P. digitatum isolates resistant to the fungicide thiabendazole was 85% RH. The disease incidence was visually evaluated at every 2-3 lower in organic fruits, while the frequency of P. digitatum isolates days. The presence of P. digitatum resistant to the fungicides was resistant to imazalil and the mixture thiabendazole+imazalil was higher assessed based on mycelial growth on potato-dextrose-agar medium in fruits that received postharvest treatment with imazalil.
CCDC 1574800: Experimental Crystal Structure Determination (2018)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Risk, Reward &amp; Regulatory Compliance – New Challenges for Geophysical Information Systems? (2007)

Today’s oil and gas companies have a strong desire to be seen as responsible, transparent organizations, good corporate citizens. They are aware of the many benefits this behavior brings and conscious that may consumers of corporate information will no longer take statements at face value. They appreciate that we need to raise our game significantly if we are to meet future challenges. So with a whole new clientele for our data how do we go about designing information systems that meet the needs of these new and often demanding consumers. The new consumers exhibit a range of stakeholder interests. They include shareholders, employees, regulatory authorities, partners, journalists, interest groups and host communities. Many are skeptical, some have detailed scientific knowledge others are generalists, all expect information to be rapidly and effectively presented using modern tools. Geophysicists themselves are also demanding access to w wide variety of data types and a range of technological tools to assist them in there work. In the eighties and nineties most geophysicists would be armed with little more than a base map and a seismic interpretation workstation. Today, information technology is involved in every step of the exploration process. The new consumers of geophysical information are driven by three broad categories of interest. This we can classify as Risk, Reward & Regulatory Compliance. Risk may be sub-divided into technical, health and safety and financial. Reward covers a range of topics from simple financial performance (studies suggest that as much as 35% of the value of a prospect may be down to intangible factors. High quality information systems help us leverage this 35%) to the kudos of being regarded as a good environmental performer or a trusted brand. Regulatory compliance is of course omnipresent and recent financial scandals and the use of legislation such as Sarbanes Oxley means that boards must be able to support their public statements with factual information other than the traditional accounting statements. Developments in information technology mean the interested parties have become accustomed to their information needs being met promptly, often in real time. They expect modern tools, internet and GIS enabled. They expect clear, simple effective presentation without recourse to information processing. The new clientele expects to access this information using the tools they have on their own PC. Failure to meet these information needs can have negative consequences for the oil and gas company. These can range from loss of reputation to regulatory censure through to reduced share price. Given that for many oil companies the market capitalization of the organization is directly related to stakeholders’ perception of potential performance, the effective communication of this information is of paramount importance. This paper will argue that the Geophysicist is key figure in meeting this challenge and has a role to play outside his or her traditional specialty.
Mass Transport Determined Silica Nanowires Growth on Spherical Photonic Crystals with Nanostructure‐Enabled Functionalities (2020)

A robust and facile method has been developed to obtain directional growth of silica nanowires (SiO<sub>2</sub> NWs) by regulating mass transport of silicon monoxide (SiO) vapor. SiO<sub>2</sub> NWs are grown by vapor-liquid-solid (VLS) process on a surface of gold-covered spherical photonic crystals (SPCs) annealed at high temperature in an inert gas atmosphere in the vicinity of a SiO source. The SPCs are prepared from droplet confined colloidal self-assembly. SiO<sub>2</sub> NW morphology is governed by diffusion-reaction process of SiO vapor, whereby directional growth of SiO<sub>2</sub> NWs toward the low SiO concentration is obtained at locations with a high SiO concentration gradient, while random growth is observed at locations with a low SiO concentration gradient. Growth of NWs parallel to the supporting substrate surface is of great importance for various applications, and this is the first demonstration of surface-parallel growth by controlling mass transport. This controllable NW morphology enables production of SPCs covered with a large number of NWs, showing multilevel micro-nano feature and high specific surface area for potential applications in superwetting surfaces, oil/water separation, microreactors, and scaffolds. In addition, the controllable photonic stop band properties of this hybrid structure of SPCs enable the potential applications in photocatalysis, sensing, and light harvesting.
Clinical Trials Targeting Metabolism in Pulmonary Arterial Hypertension (2018)

Metabolic derangement is a pathologic feature of pulmonary arterial hypertension (PAH).1 Metabolic abnormalities such as aerobic glycolysis and impaired fatty acid oxidation are consistently observed across different animal models of PAH. Importantly, altered metabolism in human PAH and experimental models is not restricted to the pulmonary vasculature, raising the possibility that PAH is a systemic metabolic disease.2 For example, lipid accumulation is present in the myocardium and skeletal muscle of humans with PAH and the right ventricle exhibits increased glucose uptake compared with matched controls. As a result of these observations, targeting metabolic dysfunction has emerged as an important therapeutic approach for patients with PAH.3 This article will review key aspects of metabolism in PAH, existing metabolic data in humans, and will describe completed and ongoing clinical trials targeting metabolic dysfunction in patients with PAH.
A proximal algorithm for joint resource allocation and minimizing carbon footprint in geo-distributed fog computing (2015)

Large-scale Internet applications, such as content distribution networks, are deployed in a geographically distributed manner and emit massive amounts of carbon footprint at the data center. To provide uniform low access latencies, Cisco has introduced Fog computing as a new paradigm which can transform the network edge into a distributed computing infrastructure for applications. Fog nodes are geographically distributed and the deployment size at each location reflects the regional demand for the application. Thus, we need to control the fraction of user traffic to data center to maximize the social welfare. In this paper, we consider the emerging problem of joint resource allocation and minimizing carbon footprint problem for video streaming service in Fog computing. To solve the largescale optimization, we develop a distributed algorithm based on the proximal algorithm and alternating direction method of multipliers (ADMM). The numerical results show that our algorithm converges to near optimum within fifteen iterations, and is insensitive to step sizes.
Blind adaptive multiuser detection for code division multiple access using Cimmino's reflection method (2009)

This paper investigates adaptive implementation of the linear minimum mean square error (MMSE) detector in code division multiple access (CDMA). From linear algebra, Cimmino's reflection method is proposed as a possible way of achieving the MMSE solution blindly. Simulation results indicate that the proposed method converges four times faster than the blind least mean squares (LMS) algorithm and has roughly the same convergence performance as the blind recursive least squares (RLS) algorithm. Moreover the proposed algorithm is numerically more stable than the RLS algorithm and also exhibits parallelism for pipelined implementation. © 2009 IEEE.
Confocal Raman microscopy for identification of bacterial species in biofilms (2011)

Implemented through a confocal microscope, Raman spectroscopy has been used to distinguish between biofilm samples of two common oral bacteria species, Streptococcus sanguinis and mutans, which are associated with healthy and cariogenic plaque, respectively. Biofilms of these species are studied as a model of dental plaque. A prediction model has been calibrated and validated using pure biofilms. This model has been used to identify the species of transferred and dehydrated samples (much like a plaque scraping) as well as hydrated biofilms in situ. Preliminary results of confocal Raman mapping of species in an intact two-species biofilm will be shown.
Is a personalized pharmacotherapeutic approach closed for acute coronary syndrome? (2021)

Improvement in reperfusion and pharmacotherapy strategies for the acute coronary syndrome (ACS) had led to a decline in mortality and morbidity; despite this ACS is still associated with substantia...