gebhart/patrepeval huggingface dataset:
Importance of the Nasal-to-Cervical Relationship to the Profile in Rhinoplasty Surgery (2001)

There is general agreement that when discussing surgery with the prospective rhinoplasty patient, one may also include discussion of the chin because of the important interrelationship between these two regions. It is apparent that on the profile-lateral view, the four prominences— the forehead, nose, chin, and neck—balance and complement one another. The cervical region, the fourth dimension, was examined to estimate the aesthetic significance of the nasal-to-cervical relationship and to determine the implications to rhinoplasty surgery. Part I of the study was a survey to test the hypothesis that the cervical region affects the perceived impression of the nose. Four standard facial-profile black-and-white photographs were chosen to represent varying degrees of nasal dorsum hump and cervical ptosis problems. Using computer-altering software, only the cervical regions were altered to create a pair of photographs for each of the four profiles: one with a youthful-looking non-ptotic cervical region, the other with a ptotic aged-looking cervical region. Raters were asked to give their first-impression opinions of which nose subjectively appeared “better.” Raters consistently (84 percent of the time) chose the nose on the faces with the less ptotic neck as being better. Therefore, a less ptotic neck improved the perceived appearance of the nose. Part II was a retrospective chart review of the rhinoplasty patients of a single surgeon by independent raters. To estimate the aesthetic significance of the nasal-to-cervical relationship, the proportion of patients undergoing rhinoplasty surgery who could have potentially benefited from a youth-restoring neck procedure was determined. Criteria originally described by Ellenbogen and Karlin for judging the results of youth-restoring neck procedures were used as relative indications for neck surgery. An average of 27.2 percent of the patients did not have visible criteria and therefore by definition had relative indications for neck-rejuvenating procedures when undergoing rhinoplasty surgery. As demonstrated in part I of the study, improving the neck could improve the perceived results of the rhinoplasty. Part III of the study validated the Ellenbogen and Karlin criteria. The present authors found that the original criteria were probably based on female patients, that male and older patients had more indications for surgery, and that there was significant interrater agreement with the youthful criteria. In summary, the authors established that a strong nasalto-cervical relationship exists whereby the perceived appearance of the nose is affected by the neck. The significance of this relationship to rhinoplasty surgery was determined, and it was found that more than 27 percent of rhinoplasty patients could obtain better perceived nasal results with a concomitant neck-rejuvenating procedure. Consequently, discussing neck-rejuvenating procedures with the rhinoplasty patient is valuable. (Plast. Reconstr. Surg. 108: 522, 2001.)
An Adaptive Superframe Duration Allocation Algorithm for Resource-Efficient Beacon Scheduling (2015)

Beacon scheduling is considered to be one of the most significant challenges for energy-efficient Low-Rate Wireless Personal Area Network (LR-WPAN) multi-hop networks. The emerging new standard, IEEE802.15.4e, contains a distributed beacon scheduling functionality that utilizes a specific bitmap and multi-superframe structure. However, this new standard does not provide a critical recipe for superframe duration (SD) allocation in beacon scheduling. Therefore, in this paper, we first introduce three different SD allocation approaches, LSB first, MSB first, and random. Via experiments we show that IEEE802.15.4e DSME beacon scheduling performs differently for different SD allocation schemes. Based on our experimental results we propose an adaptive SD allocation (ASDA) algorithm. It utilizes a single indicator, a distributed neighboring slot incrementer (DNSI). The experimental results demonstrate that the ASDA has a superior performance over other methods from the viewpoint of resource efficiency.
Using Z Boson Events to Study Parton-Medium Interactions in Pb-Pb Collision (2021)

The spectra measurements of charged hadrons produced in the shower of a parton originating in the same hard scattering with a leptonically decaying Z boson, are reported in lead-lead (PbPb) and proton-proton (pp) collisions at a nucleon-nucleon center-of-mass energy of 5.02 TeV. Both PbPb and pp data sets are recorded by the CMS experiment at the LHC, and correspond to an integrated luminosity of 1.7 nb$^{-1}$ and 320 pb$^{-1}$, respectively. Hadronic collision data with one reconstructed Z boson candidate with the transverse momentum $p_\mathrm{T} \gt$ 30 GeV/$c$ are analyzed. The Z boson constrains the initial energy and direction of the associated parton. In heavy ion events, azimuthal angular distributions of charged hadrons with respect to the direction of a Z boson are sensitive to modifications of the in-medium parton shower and medium response. Compared to reference data from pp interactions, the results for central PbPb collisions indicate a modification of the angular correlations. The measurements of the fragmentation functions and $p_\mathrm{T}$ spectra of charged particles in Z boson events, which are sensitive to medium modifications of the parton shower longitudinal structure, are also reported. Significant modifications in central PbPb events compared to pp reference data are also found for these observables.
Imaging of Chemokine Receptor 4 Expression in Neuroendocrine Tumors - a Triple Tracer Comparative Approach (2017)

C-X-C motif chemokine receptor 4 (CXCR4) and somatostatin receptors (SSTR) are overexpressed in gastro-entero-pancreatic neuroendocrine tumors (GEP-NET). In this study, we aimed to elucidate the feasibility of non-invasive CXCR4 positron emission tomography/computed tomography (PET/CT) imaging in GEP-NET patients using [<sup>68</sup>Ga]Pentixafor in comparison to <sup>68</sup>Ga-DOTA-D-Phe-Tyr3-octreotide ([<sup>68</sup>Ga]DOTATOC) and <sup>18</sup>F-fluorodeoxyglucose ([<sup>18</sup>F]FDG). Twelve patients with histologically proven GEP-NET (3xG1, 4xG2, 5xG3) underwent [<sup>68</sup>Ga]DOTATOC, [<sup>18</sup>F]FDG, and [<sup>68</sup>Ga]Pentixafor PET/CT for staging and planning of the therapeutic management. Scans were analyzed on a patient as well as on a lesion basis and compared to immunohistochemical staining patterns of CXCR4 and somatostatin receptors SSTR2a and SSTR5. [<sup>68</sup>Ga]Pentixafor visualized tumor lesions in 6/12 subjects, whereas [<sup>18</sup>F]FDG revealed sites of disease in 10/12 and [<sup>68</sup>Ga]DOTATOC in 11/12 patients, respectively. Regarding sensitivity, SSTR-directed PET was the superior imaging modality in all G1 and G2 NET. CXCR4-directed PET was negative in all G1 NET. In contrast, 50% of G2 and 80% of G3 patients exhibited [<sup>68</sup>Ga]Pentixafor-positive tumor lesions. Whereas CXCR4 seems to play only a limited role in detecting well-differentiated NET, increasing receptor expression could be non-invasively observed with increasing tumor grade. Thus, [<sup>68</sup>Ga]Pentixafor PET/CT might serve as non-invasive read-out for evaluating the possibility of CXCR4-directed endoradiotherapy in advanced dedifferentiated SSTR-negative tumors.
Knowledge Model for Selecting and Producing Reaching Movements (1993)

This article presents a new model of reaching control. The aim of the model is to characterize the computations underlying the selection of coordinated motion patterns among the limb segments. When a spatial target is selected, stored postures are evaluated for the contributions they can make to the task, and a special weighted average (the gaussian average) is taken of the postures to find a single target posture. Movement to the target posture is achieved without explicit planning of the trajectory. Rather, the reaching motion is driven by error correction (reducing the discrepancy between the current and target posture) shaped by inertia. The model solves the degrees-of-freedom problem for reaching. It also allows joints to compensate automatically for reduced mobility of other joints and explains established effects of practice, speed-accuracy trade-off, and kinematics. The model can be extended to other tasks and motor subsystems because of the generality of its underlying concepts.
Ultrasonic bone scalpel for thoracic spinal decompression: case series and technical note (2020)

Abstract Background: Thoracic spinal stenosis (TSS) is a rare but intractable disease that fails to respond to conservative treatment. Thoracic spinal decompression, which is traditionally performed using high-speed drills and kerrison rongeurs, is a time-consuming and technically challenging task. Unfavorable outcomes and high incidence of complications are the major concerns. The development and adaptation of ultrasonic bone scalpel (UBS) has promoted its application in various spinal operations, but its application and standard operating procedure in thoracic decompression have not been fully clarified. Therefore, the purpose of this study is to describe our experience and technique note of using UBS, and come up with a standard surgical procedure for thoracic spinal decompression. Methods: A consecutive of 28 patients with TSS who underwent posterior thoracic spinal decompression surgery with UBS between December 2014 and May 2015 were enrolled in this study. Results: Thoracic spinal decompression surgery was successfully carried out in all cases via a single posterior approach. The mean operative time of single-segment laminectomy was 3.0±1.4min and the blood loss was 108.3±47.3ml. In circumferential decompression, the average blood loss was 513.8±217.0ml. Two cases of instrument-related nerve root injury occurred during operation and were cured by conservative treatment. Six patients have experienced cerebrospinal fluid (CSF) leakage postoperatively, but no related complications were observed. Conclusions: The UBS is an optimal instrument for thoracic spinal decompression, and its application enables surgeons to decompress the thoracic spinal cord safely and effectively. This standard operating procedure is expected to help achieve favorable outcomes, and can be used to treat various pathologies leading to thoracic spinal stenosis.
Introduction (1993)

The prelims comprise: Definition of Mechanical Sensors From Antiquity to Now “Smart” or “Intelligent” Sensors Future Trends Comments on Sensor Selection Remarks on Further Reading References
A preliminary pharmacokinetic study of the antimalarial drugs, proguanil and chlorproguanil (1987)

Pharmacokinetic parameters for cycloguanil and chlorcycloguanil, the active metabolites of proguanil (Paludrine] and chlorproguanil (Lapudrine) have been measured in a bioassay which assesses the in-vitro growth inhibition of a cycloguanil- and chlorcycloguanil-sensitive strain of Plasmodium falciparum produced by dilutions of plasma collected after oral administration of the pro-drugs. A single compartment model is applicable for cycloguanil with mean rate constants of elimination of 0.0624 h-1 and availability of 0.2398 h-1. The elimination profile for chlorcycloguanil indicates partition of drug into more than one compartment. In 2 of 10 subjects dosed with proguanil and 1 of 11 subjects dosed with chlorproguanil, the active metabolite levels were significantly lower than the mean for the other subjects. Abnormally low cycloguanil or chlorcycloguanil plasma levels may be of importance in relation to effective prophylaxis against malaria.
A new triple staining method for double<i>in situ</i>hybridization in combination with cell lineage tracing in whole‐mount<i>Xenopus</i>embryos (2007)

To analyze cell to cell interaction effects on cell differentiation, we developed a new triple staining method for double in situ hybridization with cell lineage tracing in whole-mount Xenopus embryos. The method provides high color contrast views, and also enabled us to examine inside the embryos. Wild-type embryos whose blastomere(s) had been injected with a cell lineage tracer were cultured, fixed, hemisectioned when necessary, and first served for the double in situ hybridization, with two sequential chromogenic reactions. They were postfixed, and the labeled cells were retraced immunohistochemically. Finally, the pigment of the embryos was bleached to obtain a clear view. We applied this method to a blastomere transplantation experiment to examine whether the spatial gene expression patterns along the anteroposterior axis can be induced by cell to cell interactions. The presumptive organizer of a 32-cell embryo was replaced by the labeled presumptive epidermis of another synchronous embryo. The resultant triple-stained late gastrula showed quite similar anteroposterior expression patterns of gsc and Xbra to those of a normal embryo in the axial mesoderm derived from the transplanted presumptive epidermis, indicating that cell to cell interactions had induced these patterns.
p53 transactivation through various p53-responsive elements (1996)

p53 is a nuclear phosphoprotein whose function is classified as tumor suppression. Studies have shown that p53 functions by binding to p53 DNA recognition sequences and regulates transcription of growth-regulatory genes. Various p53 recognition sequences have recently been identified. pOST2 contained two copies of a palindromic high-affinity DNA-binding sequence for p53; the other p53 recognition sequences included p53-binding fragments found in the human ribosomal gene cluster (pRGC) region and in the murine muscle creatine kinase promoter (pMCK). The purpose of this study was to compare the abilities of various p53 recognition sequences to mediate transcription in the presence of endogenously produced wild-type (wt) or mutant p53. Three p53-responsive chloramphenicol acetyltransferase (CAT) reporter constructs (pOST2, pRGC, and pMCK) that contain one or two copies of p53 recognition sequences upstream of a herpes thymidine kinase (TK) promoter and CAT reporter cDNA were constructed. Either a p53-responsive gene or a control reporter gene was transfected into human carcinoma cell lines (having various p53 mutations) either with or without a wt or mutant p53 expression vector. CAT activity was assayed to measure transactivation through the various p53-responsive elements. We showed that pOST2 had a greater ability to mediate transactivation by p53 than either pRGC or pMCK. p53 with a mutation at either codon 175 or 248 was unable to transactivate a reporter gene with pOST2, pRGC, or pMCK. We found it interesting that pOST2, but not pRGC or pMCK, was able to mediate transactivation in cell lines that produce codon 273-mutant p53. These findings suggest that various sensitivities of the different p53-responsive elements to specific mutant and wt p53s may be an important factor in the role of p53 as a transcriptional activator both under normal physiological conditions and during carcinogenesis.
Robust strategies for lossy quantum interferometry (2009)

We give a simple multiround strategy that permits us to beat the shot-noise limit when performing interferometric measurements even in the presence of loss. In terms of the average photon number employed, our procedure can achieve twice the sensitivity of conventional interferometric ones in the noiseless case. In addition, it is more precise than the (recently proposed) optimal two-mode strategy even in the presence of loss.
Solutions to Selected Exercises (2016)

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Obstructive sleep apnea, low transferrin saturation levels, and male‐pattern baldness (2018)

These findings suggest that OSA may be a risk factor for MPB in men who have a family history of hair loss and that low serum TSA levels associated with hypoxia may be involved in a pathway linking OSA and MPB.
Formation of Germanium Nanocrystals Embedded in a Silicon-Oxygen-Nitride Layer (2007)

The formation of germanium nanocrystals embedded in silicon-oxygen-nitride with distributed charge storage elements is proposed. A large memory window was observed due to isolated Ge nanocrystals in the gate stack layer. The Ge nanocrystals were nucleated after a high-temperature oxidized layer. The Ge nanocrystals embedded in the stack layer exhibited nonvolatile memory characteristics with the obvious threshold voltage shift under a bidirectional voltage sweep. Also, the manufacturing technology using the sequent high-temperature oxidation of the a-Si layer and the direct oxidation of the layer is proposed, respectively, for the formation of a blocking oxide layer to enhance the performance of nonvolatile memory devices. The reliability characteristics, including retention time and endurance, are also advisable for the application of nonvolatile memory device.
Transfer and co-amplification of a gene encoding a 96-kDa immune IFN-inducible human melanoma-associated antigen. Preferential expression by mouse melanoma host cells. (1988)

An immune IFN-inducible human melanoma-associated glycoprotein Ag, 96-kDa MAA, having preferential distribution on metastases has been defined by mouse mAb CL203.4. To initiate molecular genetic analysis of 96-kDa MAA, the gene encoding the Ag was transfected into mouse B16 melanoma cell clone B78H1. Formation of B78H1-transfectant colonies expressing a surface Ag reactive with mAb CL203.4 in an immunorosetting assay was dependent on addition of chromosomal DNA from human melanoma cells [primary (1 degree) transfer] or from Ag-expressing transfectant cells (2 degrees, 3 degrees, 4 degrees transfer). The mAb CL203.4-reactive species expressed by the transfectant cells is a glycoprotein with a molecular mass 93-kDa, within the range of 93 to 96-kDa observed for the endogenous human Ag. In the presence of tunicamycin, an inhibitor of N-linked glycosylation, both mouse melanoma transfectants and human melanoma cells express a 50- to 51-kDa antigenic species. Human alu family repeat sequences (h-alu) are present in the genomes of 3 degrees transfectant cells. Continued presence of these h-alu after dilution of extraneous human DNA by three cycles of transfection suggests their association with the transferred 96-kDa MAA gene. Use of a selective co-amplification procedure led to transfectant cells' increased expression of 96-kDa MAA and to commensurate increases in their content of presumed 96-kDa MAA gene-associated h-alu. Preferential DNA-mediated transferability of the 96-kDa MAA+ phenotype into B78H1 cells as compared with LMTK- mouse fibroblasts suggests host cell specificity of 96-kDa MAA gene expression.
Online teaching of inflammatory skin pathology by a French-speaking International University Network (2014)

The challenges of sustaining a project of this scope are numerous. The technical aspect of whole-slide imaging and storage needs to be developed by each university or group. The content needs to be regularly updated and its accuracy reviewed by experts in each individual domain. The learning modules also need to be promoted within the academic community to ensure maximal benefit for trainees. A collateral benefit of the project was the establishment of international partnerships between French-speaking universities and pathologists with the common goal of promoting pathology education through the use of multi-media technology including whole slide imaging.
Heat engine development for solar thermal dish-electric power plants (1986)

The Department of Energy's (DOE) Solar Thermal Program has as one of its program elements the development and evaluation of heat engine technologies that are applicable to Distributed Receiver Systems. The primary research and development activities, for the past several years, have involved the so-called dish-electric concept in which a heat engine, solar receiver, and generator are coupled and located at the focus of a parabolic dish concentrator. Power conversion assemblies (PCA) would be deployed at the size of about 25 to 50 kWe, which is consistent with concentrator development in the 11 to 15 m diameter range. This report describes various heat engine cycles, outlines the status of their development, presents test data and performance evaluation from experimental work to date, and discusses the strategy for future development efforts.
Impaired Activation of Islet-Reactive CD4 T Cells in Pancreatic Lymph Nodes of B Cell-Deficient Nonobese Diabetic Mice (2001)

Despite the impressive protection of B cell-deficient (muMT(-/-)) nonobese diabetic (NOD) mice from spontaneous diabetes, existence of mild pancreatic islet inflammation in these mice indicates that initial autoimmune targeting of beta cells has occurred. Furthermore, muMT(-/-) NOD mice are shown to harbor a latent repertoire of diabetogenic T cells, as evidenced by their susceptibility to cyclophosphamide-induced diabetes. The quiescence of this pool of islet-reactive T cells may be a consequence of impaired activation of T lymphocytes in B cell-deficient NOD mice. In this regard, in vitro anti-CD3-mediated stimulation demonstrates impaired activation of lymph node CD4 T cells in muMT(-/-) NOD mice as compared with that of wild-type counterparts, a deficiency that is correlated with an exaggerated CD4 T cell:APC ratio in lymph nodes of muMT(-/-) NOD mice. This feature points to an insufficient availability of APC costimulation on a per T cell basis, resulting in impaired CD4 T cell activation in lymph nodes of muMT(-/-) NOD mice. In accordance with these findings, an islet-reactive CD4 T cell clonotype undergoes suboptimal activation in pancreatic lymph nodes of muMT(-/-) NOD recipients. Overall, the present study indicates that B cells in the pancreatic lymph node microenvironment are critical in overcoming a checkpoint involving the provision of optimal costimulation to islet-reactive NOD CD4 T cells.
Aerodynamic Control of Using Windward-Surface Plasma Actuators on a Separation Ramp (2007)

Wind-tunnel experiments were cone ucted on a 47-deg sweep, scaled 1303 unmanned air vehicle model to assess the performance of an innovative windwiird-surface plasma actuator design for flight control at low angles of attack. Control was implemented by altering the flow past an aft separation ramp on the windward side using a single dielectric barrier discharge plasma actuator. The influence of ramp-expansion angles (20, 30, and 40 deg) on the plasma actuator's ability to affect flow separation and aerodynamic lift was examined. Both steady and unsteady actuations of the plasma actuator were examined, and their effects were captured using lift measurements and flow visualizations. Results reveal that the plasma actuator effects are highly dependent on the ramp angle and actuator parameters such as duty cycle and modulation frequency. The actuators produced significant shifts in the lift curve, up to 25% for the most effective ramp angles of 20 and 30 deg, in the 0-20-deg a range. Flow visualization results, confirmed that the plasma actuator causes the flow to reattach over a region downstream of the separation ramp. For all ramp cases examined, the unsteady (pulsed) actuator was more effective than the steady actuator in controlling flow separation and influencing the aerodynamic lift. The aerodynamic effect of plasma actuators was found to be highly dependent on the ramp angle and the separation strength over the ramp. Significant control forces were obtained using windward-surface plasma actuators and, indirectly, these control forces can be implemented to generate substantial control moments for maneuvering air vehicles.