gebhart/patrepeval huggingface dataset:
Biomechanical aspects of catheter-related thrombophlebitis (2013)

Short peripheral catheters (SPCs) are the most common intravenous devices used in medical practice. Short peripheral catheter thrombophlebitis (SPCT) is the most frequent complication associated with SPCs, causing discomfort and usually leading to removal of the catheter and insertion of a new one at a different site. The aim of this research was to explore whether biomechanical factors, in addition to biochemical factors, also play a role in the formation of thrombophlebitis. Hence, two of the biomechanical aspects of SPCT were investigated: the physical pressure load exerted by the SPC on the endothelial monolayer, and disturbances in the flow patterns due to the SPC. Endothelial activation was studied by subjecting human umbilical vein endothelial cells (HUVEC) to a weight load of SPC pieces and measuring the release profile of von-Willebrand Factor (vWF) over time, using ELISA. vWF release was chosen as the measure for endothelial activation since it was the major component of the Weibel-Palade Bodies (WPBs), which underwent exocytosis by endothelial cells during activation. Flow patterns were analyzed on a 3D computational fluid dynamics (CFD) model of a brachiocephalic vein with SPC. vWF release profiles were significantly higher in the HUVECs subjected to the load, indicating HUVEC activation. CFD simulations demonstrated a decrease in flow velocities along the catheter body, between the catheter and the vein, due to an enlarged boundary layer. Results indicate that the contact region between the SPC body and the vein wall can be partially responsible for SPCT development, and inflammatory and coagulatory processes initiated by stimulated endothelial cells may be amplified due to disturbed blood flow.
SUCCESSFUL MACULAR TRANSLOCATION WITH TEMPORARY SCLERAL INFOLDING USING ABSORBABLE SUTURE (2001)

Temporary scleral infolding is an effective technique in MTSI. The distance of translocation is comparable to that achieved with nonabsorbable suture or scleral resection, and does not regress after resolution of the scleral infolding. Induced postoperative corneal astigmatism appears to resolve.
Data from ONC201 Targets AR and AR-V7 Signaling, Reduces PSA, and Synergizes with Everolimus in Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;Androgen receptor (AR) signaling plays a key role in prostate cancer progression, and androgen deprivation therapy (ADT) is a mainstay clinical treatment regimen for patients with advanced disease. Unfortunately, most prostate cancers eventually become androgen-independent and resistant to ADT with patients progressing to metastatic castration-resistant prostate cancer (mCRPC). Constitutively activated AR variants (AR-V) have emerged as mediators of resistance to AR-targeted therapy and the progression of mCRPC, and they represent an important therapeutic target. Out of at least 15 AR-Vs described thus far, AR-V7 is the most abundant, and its expression correlates with ADT resistance. ONC201/TIC10 is the founding member of the imipridone class of small molecules and has shown anticancer activity in a broad range of tumor types. ONC201 is currently being tested in phase I/II clinical trials for advanced solid tumors, including mCRPC, and hematologic malignancies. There has been promising activity observed in patients in early clinical testing. This study demonstrates preclinical single-agent efficacy of ONC201 using &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; models of prostate cancer. ONC201 has potent antiproliferative and proapoptotic effects in both castration-resistant and -sensitive prostate cancer cells. Furthermore, the data demonstrate that ONC201 downregulates the expression of key drivers of prostate cancer such as AR-V7 and downstream target genes including the clinically used biomarker PSA (KLK3). Finally, the data also provide a preclinical rationale for combination of ONC201 with approved therapeutics for prostate cancer such as enzalutamide, everolimus (mTOR inhibitor), or docetaxel.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Implications:&lt;/b&gt; The preclinical efficacy of ONC201 as a single agent or in combination, in hormone-sensitive or castration-resistant prostate cancer, suggests the potential for immediate clinical translation. &lt;i&gt;Mol Cancer Res; 16(5); 754–66. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Lytic Cycle of<i>Toxoplasma gondii</i> (2000)

Toxoplasma gondii is an obligate intracellular pathogen within the phylum Apicomplexa. This protozoan parasite is one of the most widespread, with a broad host range including many birds and mammals and a geographic range that is nearly worldwide. While infection of healthy adults is usually relatively mild, serious disease can result in utero or when the host is immunocompromised. This sophisticated eukaryote has many specialized features that make it well suited to its intracellular lifestyle. In this review, we describe the current knowledge of how the asexual tachyzoite stage of Toxoplasma attaches to, invades, replicates in, and exits the host cell. Since this process is closely analogous to the way in which viruses reproduce, we refer to it as the Toxoplasma "lytic cycle."
Examination of the obstetric patient (2011)

Abstracts and keywords to be supplied.
One‐step synthesis of macromonomers catalyzed by phosphazene base (2020)

Abstract Herein, we report one‐step synthesis of polymethacrylates‐based macromonomers (MMs) in the presence of an organocatalyst phosphazene base ( t ‐BuP 4 ) and a functional initiator N ‐butyl‐4‐vinylbenzamide ( N ‐BVBA) containing a secondary amide and a styrenic double bond. A series of styrenic MMs with controlled molecular weight and relatively narrow polydispersity were synthesized under mild conditions. Detailed NMR analyses of the initiation process suggested that the anionic polymerization was initiated by nitrogen anion generated from abstraction of the proton from the secondary amide. NMR and MALDI‐TOF MS analyses confirmed: (1) the selective polymerization of methacrylate‐type double bonds, (2) controlled chain‐end functionality of MMs with an unreacted styrenic double bond, as well as (3) the absence of transesterification between N ‐BVBA and methacrylate monomers. Furthermore, the homopolymerization and copolymerization of the MMs with comonomers were carried out for the preparation of graft copolymers. Through conventional radical polymerization, graft copolymers with different grafting densities were obtained at high MMs conversions, indicating the high reactivity of MMs. Thus, the one‐step approach demonstrates a simple metal‐free access to the controlled synthesis of MMs, and the prepared MMs can polymerize efficiently to convert into graft copolymers.
The invertibility of the XOR of rotations of a binary word (2010)

We prove the following result regarding operations on a binary word whose length is a power of two: computing the exclusive-or of a number of rotated versions of the word is an invertible (one-to-one) operation if and only if the number of versions combined is odd. (This result is not new; there is at least one earlier proof, due to Thomsen [Cryptographic hash functions, PhD thesis, Technical University of Denmark, 28 November 2008]. Our proof may be new.)
Modeling of Magneto-Mechanical Coupling with Magnetic Volume Integral and Mechanical Finite Element Methods (2014)

International audience
Innovative methods for Burn-In related Stress Metrics Computation (2021)

Burn-In equipment provide both external and internal stress to the device under test. External stress, such as thermal stress, is provided by a climatic chamber or by socket-level local temperature forcing tools, and aims at aging the circuit material, while internal stress, such as electrical stress, consists in driving the circuit nodes to produce a high internal activity. To support internal stress, Burn-In test equipment is usually characterized by large memory capabilities required to store precomputed patterns that are then sequenced to the circuit inputs. Because of the increasing complexity and density of the new generations of SoCs, evaluating the effectiveness of the patterns applied to a Device under Test (DUT) through a simulation phase requires long periods of time. Moreover, topology-related considerations are becoming more and more important in modern high-density designs, so a way to include this information into the evaluation has to be devised. In this paper we show a feasible solution to this problem: the idea is to load in the DUT a pattern not by shifting inside of it a bit at a time but loading the entire pattern at once inside of it; this kind of procedure allows for conservative stress measures, thus it fits for stress analysis purposes. Moreover, a method to take the topology of the DUT into account when calculating the activity metrics is proposed, so to obtain stress metrics which can better represent the activity a circuit is subject to. An automotive chip accounting for about 20 million of gates is considered as a case of study. Resorting to it we show both the feasibility and the effectiveness of the proposed methodology.
Design of an Actuator using DC motor for Vibrotactile Presentation in Low Frequency (2016)

Similar to Haptuator from Tactile Labs Inc. and Force Reactor from Alps Electric Co., DC motor can produce high fidelity vibration when it is driven by alternative current such as audio input signal. In our study, we developed a new vibration actuator using a DC motor that can generate much stronger vibrations than a normal DC motor and produce very low frequency of vibrations. We proposed that the stator of the motor could be used as the vibration mass by fixing the rotor of the actuator. To evaluate this design concept, we developed a prototype actuator that can be driven in two modes: stator mode (i.e., the new design concept) and normal mode. The experiment results revealed that stronger vibrations can be obtained on a fingertip in stator mode because the fixed part that comprises the rotor was lighter and the vibration mass using the stator was heavier. We also confirmed that the actuator can be driven at very low frequency (1 Hz) in stator mode.
The DNA sensors AIM2 and IFI16 are NET-binding SLE autoantigens (2021)

Abstract Nucleic acid binding proteins are frequently targeted as autoantigens in systemic lupus erythematosus (SLE) and other interferon (IFN)-linked rheumatic diseases. The AIM-like receptors (ALRs) are IFN-inducible innate sensors that form supramolecular assemblies along double-stranded DNA of various origins. Here, we identify the ALR Absent in melanoma 2 (AIM2) as a novel autoantigen in SLE, with similar properties to the established ALR autoantigen interferon-inducible protein 16 (IFI16). Our SLE cohort revealed a frequent co-occurrence of anti-AIM2, anti-IFI16 and anti-DNA antibodies, and higher clinical measures of disease activity in patients positive for antibodies against these ALRs. We examined neutrophil extracellular traps (NETs) as DNA scaffolds on which these antigens might interact in a pro-immune context, finding that both ALRs bind NETs in vitro and in SLE renal tissues. We demonstrate that ALR binding causes NETs to resist degradation by DNase I, suggesting a mechanism whereby extracellular ALR-NET interactions may promote sustained IFN signaling. Our work suggests that extracellular ALRs bind NETs, leading to DNase resistant nucleoprotein fibers that are targeted as autoantigens in SLE.
The first-in-human phase I study of a brain-penetrant mutant IDH1 inhibitor DS-1001 in patients with recurrent or progressive IDH1-mutant gliomas (2022)

DS-1001 was well tolerated with a favorable brain distribution. Recurrent/progressive IDH1-mutant glioma patients responded to treatment. A study of DS-1001 in patients with chemotherapy- and radiotherapy-naïve IDH1-mutated WHO grade 2 glioma is ongoing (NCT04458272).
The Evolution of Thermal Barrier Coatings in Gas Turbine Engine Applications (1992)

Thermal barrier coatings (TBCs) have been used for almost three decades to extend the life of combustors and augmentors and, more recently, stationary turbine components. Plasma sprayed yttria stabilized zirconia TBC currently is bill-of-material on many commercial jet engine parts. A more durable electron beam-physical vapor deposited (EB-PVD) ceramic coating recently has been developed for more demanding rotating as well as stationary turbine components. This ceramic EB-PVD is bill-of-material on turbine blades and vanes in current high thrust engine models and is being considered for newer developmental engines as well. To take maximum advantage of potential TBC benefits, the thermal effect of the TBC ceramic layer must become an integral element of the hot section component design system. To do this with acceptable reliability requires a suitable analytical life prediction model calibrated to engine experience. The latest efforts in thermal barrier coatings are directed toward correlating such models to measured engine performance.
Colloid cysts of the third ventricle: Immunohistochemical evidence for nonneuroepithelial differentiation (1992)

The histogenesis of colloid cysts (CCs) of the third ventricle has been a subject of controversy. We examined, using immunohistochemical techniques, four CCs for the presence of cytokeratins (CKs), glutathione S-transferase isoenzymes (GST-pi, GST-mu), and glial fibrillary acidic protein. Antibodies to both low molecular weight CKs (anti-CK8) and to a mixture of CKs (AE1/AE3) were used. For comparison, normal fetal and adult choroid plexus, ependyma, and nasal mucosa were also examined. The epithelium lining all four CCs showed positive immunostaining for the CKs and GST-pi but not for GST-mu or glial fibrillary acidic protein. Fetal and adult nasal mucosa showed a pattern of immunohistochemical staining almost identical to that of CCs. In contrast, fetal and adult choroid plexus tissue showed positive immunostaining for GST-pi and low molecular weight CKs but not for the CK mixture (AE1/AE3). Fetal and adult ependyma were negative for both CKs and GST-pi. These results suggest that CCs differentiate along nonneural lines distinct from the neuroepithelial differentiation of the choroid plexus and ependyma.
Inhibition of Chitosan with Different Molecular Weights on Barley-Borne Fusarium graminearum during Barley Malting Process for Improving Malt Quality (2022)

There are many <i>Fusarium graminearum</i> contaminations in barley that are often associated with malt and beer quality issues. Thus, it is important to find a biological antifungal agent to prevent the growth of <i>F. graminearum</i> during malting. Minimum inhibition concentration (MIC) of chitosan for mycelial growth and spore germination of <i>F. graminearum</i> was 2.6 g/L and 1.6 g/L, respectively, indicating that the <i>F. graminearum</i> strain was highly sensitive toward chitosan. Chitosan with a molecular weight of 102.7 kDa was added at 0.5 g/kg during the first steeping stage, resulting in the maximum inhibition rate of <i>F. graminearm</i> in barley. The biomass of <i>F. graminearm</i> and deoxynivalenol content in the infected barley at the end of germination with 0.5 g/kg chitosan treatment were decreased by 50.7% and 70.5%, respectively, when compared with the infected barley without chitosan. Chitosan could remove the negative effects of <i>F. graminearm</i> infection on barley germination and malt quality, which makes the application of chitosan during the steeping process as a potential antifungal agent in the malting process to protect from <i>F. graminearum</i> infection.
HDR-GAN: HDR Image Reconstruction From Multi-Exposed LDR Images With Large Motions (2021)

Synthesizing high dynamic range (HDR) images from multiple low-dynamic range (LDR) exposures in dynamic scenes is challenging. There are two major problems caused by the large motions of foreground objects. One is the severe misalignment among the LDR images. The other is the missing content due to the over-/under-saturated regions caused by the moving objects, which may not be easily compensated for by the multiple LDR exposures. Thus, it requires the HDR generation model to be able to properly fuse the LDR images and restore the missing details without introducing artifacts. To address these two problems, we propose in this paper a novel GAN-based model, HDR-GAN, for synthesizing HDR images from multi-exposed LDR images. To our best knowledge, this work is the first GAN-based approach for fusing multi-exposed LDR images for HDR reconstruction. By incorporating adversarial learning, our method is able to produce faithful information in the regions with missing content. In addition, we also propose a novel generator network, with a reference-based residual merging block for aligning large object motions in the feature domain, and a deep HDR supervision scheme for eliminating artifacts of the reconstructed HDR images. Experimental results demonstrate that our model achieves state-of-the-art reconstruction performance over the prior HDR methods on diverse scenes.
Retinal complications during interferon therapy for chronic hepatitis C. (1996)

These results suggest that retinopathy often occurs in patients with chronic hepatitis C who are receiving IFN and that we should closely monitor patients for retinal complications during IFN therapy.
An Attenuated Strain of the Facultative Intracellular Bacterium<i>Francisella tularensis</i>Can Escape the Phagosome of Monocytic Cells (2003)

The facultative intracellular bacterium Francisella tularensis is a highly virulent and contagious organism, and little is known about its intracellular survival mechanisms. We studied the intracellular localization of the attenuated human vaccine strain, F. tularensis LVS, in adherent mouse peritoneal cells, in mouse macrophage-like cell line J774A.1, and in human macrophage cell line THP-1. Confocal microscopy of infected J774A.1 cells indicated that during the first hour of infection the bacteria colocalized with the late endosomal-lysosomal glycoprotein LAMP-1, but within 3 h this colocalization decreased significantly from approximately 60% to 30%. Transmission electron microscopy revealed that >90% of bacteria were not enclosed by a phagosomal membrane after 2 h of infection, and some bacteria were in vacuoles that were only partially surrounded by a limiting membrane. Similar findings were obtained with all three host cell types. Immunoelectron microscopy performed with an F. tularensis LVS-specific polyclonal rabbit antiserum showed that the antiserum stained a thick, evenly distributed capsule-like material in bacteria grown in broth. In contrast, intracellular F. tularensis LVS cells were only marginally stained with this antiserum. Instead, most of the immunoreactive material was diffusely localized in the phagosomes or was associated with the phagosomal membrane. Our findings indicate that F. tularensis LVS is able to escape from the phagosomes of macrophages via a mechanism that may involve degradation of the phagosomal membrane.
Editorial: Organohalide Respiration: New Findings in Metabolic Mechanisms and Bioremediation Applications (2019)

10.3389/fmicb.2019.00526
Supplementary Figure 2 from Visible Drug Delivery by Supramolecular Nanocarriers Directing to Single-Platformed Diagnosis and Therapy of Pancreatic Tumor Model (2023)

Supplementary Figure 2 from Visible Drug Delivery by Supramolecular Nanocarriers Directing to Single-Platformed Diagnosis and Therapy of Pancreatic Tumor Model
ChemInform Abstract: 2‐Cyanopyrrolidides as Potent, Stable Inhibitors of Dipeptidyl Peptidase IV (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Photophysical and Photochemical Processes of 9,10-Dihydro-9-silaphenanthrene Derivatives:  Photochemical Formation and Electronic Structure of 9-Silaphenanthrenes (2006)

Photophysical and photochemical processes of 9-methyl- and 9-phenyl-9,10-dihydro-9-silaphenanthrene derivatives have been studied at room temperature and 77 K in comparison with the carbon analogue, 9,10-dihydrophenanthrene. These 9,10-dihydro-9-silaphenanthrene derivatives show smaller fluorescence quantum yield and remarkably larger Stokes shifts than those of the carbon analogue. In contrast, their phosphorescence quantum yields are two times larger than those of the carbon analogue, although the absolute value is not so large (approximately 0.1). Reaction products and intermediates produced by the 266 nm light photolysis have been studied, and it has been confirmed that 9-methyl- and 9-phenyl-9-silaphenanthrenes have been photochemically formed in methylcyclohexane at 77 K, in addition to the formation of radical cations of 9,10-dihydro-9-silaphenanthrene derivatives and the carbon-centered radical: 9-hydro-9-silaphenanthrenyl radical.
Gaussian process modelling of austenite formation in steel (1999)

The present paper introduces the Gaussian process model for the empirical modelling of the formation of austenite during the continuous heating of steels. A previous paper has examined the application of neural networks to this problem, but the Gaussian process model is a more general probabilistic model which avoids some of the arbitrariness of neural networks, and is somewhat more amenable to interpretation. It is demonstrated that the model leads to an improvement in the significance of the trends of the Ac1 and Ac3 temperatures as a function of the chemical composition and heating rate. In some cases, these predicted trends are more plausible than those obtained with the neural network analysis. Additionally, it is shown that many of the trace alloying elements present in steels are irrelevant in determining the austenite formation temperatures.
Tumor suppressive Ca2+ signaling is driven by IP3 receptor fitness (2017)

Tumor suppressive Ca2+ signaling is driven by IP3 receptor fitness – Intracellular Ca2+ signals critically control a plethora of cellular functions, of which many impact cellular death and/or survival, processes often dysregulated in cancer . In healthy cells, Ca2+ signaling is employed for normal cell physiology and survival functions . Yet, when a cell is exposed to toxic stimuli or suffering from enduring cell stress, like (...)
Direct B-Alkyl Suzuki−Miyaura Cross-Coupling of 2-Halopurines. Practical Synthesis of ST1535, a Potent Adenosine A<sub>2A</sub> Receptor Antagonist (2010)

The scope and limitations of using palladium-catalyzed cross-coupling reactions of diverse butyl metal species with two different 2-halopurines were evaluated. While tributylboranes reacted readily and regioselectively with both 2-chloro-6-dibenzylaminopurines and 2-iodo-6-chloropurines, all the other alkyl metal species were much less reactive and gave very poor yield and/or selectivity of the desired product. This protocol was applied to the synthesis of an important adenosine A(2A) receptor antagonist, ST1535.
Reconfigurable Intelligent Surfaces for the Connectivity of Autonomous Vehicles (2021)

The use of real-time software-controlled reconfigurable intelligent surface (RIS) units is proposed to increase the reliability of vehicle-to-everything (V2X) communications. The optimum placement problem of the RIS units is formulated by considering their sizes and operating modes. The solution of the problem is given, where it is shown that the placement of the RIS depends on the locations of the transmitter and the receiver. The proposed RIS-supported highway deployment can combat the high path loss experienced by the use of higher frequency bands, including the millimeter-wave and the terahertz bands, that are expected to be used in the next-generation wireless networks, enabling the use of the existing base station deployment plans to remain operational, while providing reliable and energy-efficient connectivity for autonomous vehicles.