gebhart/patrepeval huggingface dataset:
Integrating the Hallmarks of Aging Throughout the Tree of Life: A Focus on Mitochondrial Dysfunction (2020)

Since the identification and definition of the hallmarks of aging, these aspects of molecular and cellular decline have been most often described as isolated or distinct mechanisms. However, there is significant evidence demonstrating interplay between most of these hallmarks and that they have the capacity to influence and regulate one another. These interactions are demonstrable across the tree of life, yet not all aspects are conserved. Here, we describe an integrative view on the hallmarks of aging by using the hallmark "mitochondrial dysfunction" as a focus point, and illustrate its capacity to both influence and be influenced by the other hallmarks of aging. We discuss the effects of mitochondrial pathways involved in aging, such as oxidative phosphorylation, mitochondrial dynamics, mitochondrial protein synthesis, mitophagy, reactive oxygen species and mitochondrial DNA damage in relation to each of the primary, antagonistic and integrative hallmarks. We discuss the similarities and differences in these interactions throughout the tree of life, and speculate how speciation may play a role in the variation in these mechanisms. We propose that the hallmarks are critically intertwined, and that mapping the full extent of these interactions would be of significant benefit to the aging research community.
Darstellung und Reaktionen des Tetramethylammonium-4.6-dimethyl-1.3.3.5.5-pentaoxo-1 λ<sup>6</sup>3 λ<sup>6</sup>5 λ<sup>6</sup>2,4,6-perhydrotrithiatriazin-1-olats / Preparation and Reactions of Tetramethylammonium-4,6-dimethyl-1,3,3,5,5-pentaoxo-1 λ<sup>6</sup>, 3 λ<sup>6</sup>, 5 λ<sup>6</sup>,2,4,6-perhydrotrithiatriazin- 1 -olat (1977)

Reaction of 2,4,6-trimethyl-1,1,3,3,5,5-hexaoxo-1 λ 6 -,3 λ 6 -,5 λ 6 -,2,4,6-perhydrotrithiatriazin, (CH 3 NSO 2 ) 3 (2), with trimethylamin forms a tetramethylammonium salt N(CH 3 ) 4 ⁺[(CH 3 NSO 2 ) 2 (NSO 2 )]- (3). From 3 a silver-salt can be obtained which reacts with ethyl-iodide to form a mixed alkylated covalent derivative of 2.
Loop Gain As a Means to Predict a Positive Airway Pressure Suppression of Cheyne-Stokes Respiration in Patients with Heart Failure (2011)

Our novel LG estimate enables quantification of the severity of ventilatory instability underlying PB, making possible a priori selection of patients whose PB is immediately treatable with CPAP therapy.
Wire bonded MEMS-scale on-chip transformers (2014)

We present a novel, wafer-level fabrication method of 3D solenoidal microtransformers using an automatic wire bonder. Automatic wire bonders allow to precisely shape 25 μm diameter wire around prefabricated yokes or magnetic cores within seconds. Former reports of wire bonded microcoils treated individual solenoids showing low mutual inductances, whereas in this study transformers with strongly coupled microsolenoids are presented. The process is fully compatible with standard microelectronic manufacturing, therefore, enables the direct integration of transformers into a given electronic circuit. Two different prototypes are presented here. A non-magnetic core transformer with a footprint of 1 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 20 windings in both the primary and the secondary coil, yields a power efficiency of 67% and a coupling factor of 94%. A magnetic core transformer with a footprint of 0.64 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> and 18 windings in both the primary and the secondary coil, yields more than 1 μH inductance and 74% power efficiency with a coupling factor of 98%. The feasibility of both prototypes with respect to the power conversion in miniaturized circuits is evaluated. Finally, the microtransformers are benchmarked to underline the potential of the wire bonded microtransformers compared to other state-of-the-art publications.
Efficacy, Safety, and Tolerability of Pridopidine in Huntington Disease (HD): Results from the Phase II, Double-blind, Placebo-controlled, Dose-Ranging Study, Pride-HD (P2.005) (2017)

To assess efficacy and safety/tolerability of four doses of pridopidine in HD patients demonstrating signs of motor dysfunction.
Pretherapeutic Dosimetry in Patients Affected by Metastatic Thyroid Cancer Using 124I PET/CT Sequential Scans for 131I Treatment Planning (2014)

The quantitative value of I PET/CT allows simple and accurate evaluation of lesion dosimetry following medical internal radiation dose formalism. Negative I PET/CT predicts absence of iodine avidity, potentially allowing avoidance of therapeutically ineffective I administration.
Secretory Anti-erbB-2 scFv Gene Therapy for Breast Cancer (2002)

Abstract : Single chain antibodies (scFv) represent powerful interventional agents for the achievement of targeted therapeutics. The practical utility of these agents have been limited, however, by difficulties related to production of recombinant scFv and the achievement of effective and sustained levels of scFv in situ. To circumvent these limitations, we have developed an approach to express scFv in vivo. An anti-erbB2 scFv was engineered for secretion by eukaryotic cells. The secreted scFv could bind to its target and specifically suppress cell growth of erbB2-positive cells in vitro. Adenoviral vectors expressing the cDNA for the secretory scFv likewise could induce target cells to produce an anti-tumor anti-erbB2 scFv. In vivo gene transfer via the anti-erbB2 scFv encoding adenovirus also showed anti-tumor effects. Thus, by virtue of engineering a secreted version of the anti-tumor anti-erbB-2 scFv, and in vivo expression via adenoviral vector, effective concentrations of scFv were achieved. In vivo gene transfer clearly represents a powerful means to realize effective scFv-based approaches. This method will likely have applicability for a range of disorders amenable to targeted therapeutic approaches.
Ruddlesden-Popper Phase Formation in Pb(Zr,Ti)O<sub>3</sub> Thin Films (2008)

In this work, we give evidences of Ruddlesden-Popper (RP) phase formation in Pb(Zr,Ti)O 3 thin films deposited by multi-target reactive sputtering at a substrate temperature of 520°C onto oxidized silicon wafers comprising a ZrO 2 buffer layer. X-ray diffraction data of films deposited at 520°C revealed the appearance of a Pb 2 (Zr,Ti)O 4 RP phase. High-resolution transmission electron microscopy (HRTEM) images have proved the presence of a corresponding superstructure with a period of about 1.3 nm. It was nucleated on top of an amorphous, lead-enriched interface layer near the ZrO 2 /PZT interface. At higher substrate temperatures, when this amorphous interface layer disappears, a perovskite structure with a sharp interface was nucleated directly on the ZrO 2 buffer layer.
Melatonin-Induced Temporal Up-Regulation of Gene Expression Related to Ubiquitin/Proteasome System (UPS) in the Human Malaria Parasite Plasmodium falciparum (2014)

There is an increasing understanding that melatonin and the ubiquitin/ proteasome system (UPS) interact to regulate multiple cellular functions. Post-translational modifications such as ubiquitination are important modulators of signaling processes, cell cycle and many other cellular functions. Previously, we reported a melatonin-induced upregulation of gene expression related to ubiquitin/proteasome system (UPS) in Plasmodium falciparum, the human malaria parasite, and that P. falciparum protein kinase 7 influences this process. This implies a role of melatonin, an indolamine, in modulating intraerythrocytic development of the parasite. In this report we demonstrate by qPCR analysis, that melatonin induces gene upregulation in nine out of fourteen genes of the UPS, consisting of the same set of genes previously reported, between 4 to 5 h after melatonin treatment. We demonstrate that melatonin causes a temporally controlled gene expression of UPS members.
Inducing pH Responsiveness via Ultralow Thiol Content in Polyacrylamide (Micro)Gels with Labile Crosslinks (2007)

Here we present the synthesis and characterization of pH responsive polyacrylamide microgels, synthesized via free radical polymerization of acrylamide and bis (acryloylcystamine) (BAC). The gels were made with ultralow amounts of thiol functional groups incorporated into the polymer. The resulting gel monoliths were mechanically chopped into microgel particles with size distributions ranging from 80 to 200 mum. The gels exhibit an interesting reversible pH-dependent rheological behavior which led to gelling of the colloidal suspension when the pH was increased, and a low-viscosity suspension was obtained when the pH was taken back to the original value. The viscosity of the colloidal system containing MBA crosslinked microgels remained insensitive to pH. This observation motivated further analysis; viscosity measurements of the highly viscous (gel-like) state of the BAC crosslinked microgel colloidal suspension were carried out to further understand the rheological behavior of the colloidal system. Electrophoretic mobility measurements as function of pH of the BAC and MBA crosslinked colloidal polyacrylamide microgel suspensions were performed. The swelling behavior of the microgels for both colloidal systems was also determined as function of pH using static light scattering. This swelling behavior was used to rationalize the observed rheological behavior. The work presented here demonstrates that free thiol groups present within a polymer gel matrix confer pH responsive behavior to the gel in solution. The viscosity of a BAC crosslinked microgel suspension was also measured under reducing conditions. The viscosity of the microgel suspension reduced with time, due to the breakage of the disulfide bonds in the crosslinkers.
Molecular Encryption and Steganography Using Mixtures of Simultaneously Sequenced, Sequence-Defined Oligourethanes (2022)

Molecular encoding in abiotic sequence-defined polymers (SDPs) has recently emerged as a versatile platform for information and data storage. However, the storage capacity of these sequence-defined polymers remains underwhelming compared to that of the information storing biopolymer DNA. In an effort to increase their information storage capacity, herein we describe the synthesis and simultaneous sequencing of eight sequence-defined 10-mer oligourethanes. Importantly, we demonstrate the use of different isotope labels, such as halogen tags, as a tool to deconvolute the complex sequence information found within a heterogeneous mixture of at least 96 unique molecules, with as little as four micromoles of total material. In doing so, relatively high-capacity data storage was achieved: 256 bits in this example, the most information stored in a single sample of abiotic SDPs without the use of long strands. Within the sequence information, a 256-bit cipher key was stored and retrieved. The key was used to encrypt and decrypt a plain text document containing <i>The Wonderful Wizard of Oz</i>. To validate this platform as a medium of molecular steganography and cryptography, the cipher key was hidden in the ink of a personal letter, mailed to a third party, extracted, sequenced, and deciphered successfully in the first try, thereby revealing the encrypted document.
Case report of a pregnant patient with systemic lupus erythematosus with uterine atony and very thin myometrium with uterine fibrosis (2017)

A pregnant patient with systemic lupus erythematosus experienced hypertension and underwent cesarean delivery. They experienced uterine atony and a very thin myometrium with uterine fibrosis.
PK/PD strategy. (2016)

&lt;p&gt;Workflow of PK and PD modeling approach towards human efficacious dose prediction. Abbreviations: maximum observed plasma concentration (C&lt;sub&gt;max&lt;/sub&gt;) and, area under the concentration versus time curve (AUC).&lt;/p&gt;
[PP.22.09] RENAL NATRIURETRIC SYSTEMS ALTERATION IN FRUCTOSE-OVERLOADED HYPERTENSIVE RATS (2016)

Objective: Metabolic and hemodynamic changes induced by a high fructose diet could be associated with an impairment of renal natriuretic systems, which contributes to sodium retention and hypertension. There is little evidence about renal dopamine (DA) and type-A natriuretic peptide (ANP) interaction on blood pressure elevation in this model. The aim of this study was to evaluate both natriuretic systems in fructose-overloaded rats. Design and method: Male Sprague Dawley rats were randomly assigned: a) Controls (C, tap water to drink) and b) Fructose overloaded: (F, 10% w/v of fructose to drink), treated during 4, 8 and 12 weeks (n = 8 rats/group/period). Urinary L-dopa and DA (HPLC); diuresis, creatinine and sodium were measured in 24 hour urine samples; and ANP (ELISA), triglycerides, glycemia, cholesterol, insulinemia, creatinine and sodium in plasma. Systolic blood pressure (SBP) was determined by tail-cuff and renal tissue protein expression of L-dopa transporter (LAT-2), D1R and NPR-A receptors by Western blot. Results: Fructose overload increased SBP (mmHg, C4: 121 ± 8 vs. F4: 145 ± 1*; C8: 130 ± 4 vs. F8: 161 ± 10#; C12: 133 ± 5 vs. F12: 163 ± 4#), which positively correlated (R2 = 0.78; p < 0.002) to urinary L-dopa/DA index (C4: 0.49 ± 0.05 vs. F4: 1.9 ± 0.09#; C8: 0.53 ± 0.06 vs. F8: 2.35 ± 0.10#; C12: 0.54 ± 0.07 vs. F12: 2.57 ± 0.20#). An elevation in cortex LAT-2 expression (arbitrary units) (C4: 1.00 ± 0.02 vs. F4: 1.30 ± 0.04*; C8: 1.00 ± 0.05 vs. F8: 1.23 ± 0.09*; C12: 1.00 ± 0.06 vs. F12: 1.40 ± 0.01*) and medulla (C8: 1.00 ± 0.01 vs. F8: 1.42 ± 0.02*; C12: 1.00 ± 0.01 vs. F12: 1.46 ± 0.04*); and a decrease D1R in cortex (C4: 1.00 ± 0.05 vs. F4: 0.72 ± 0.08*; C8: 1.00 ± 0.05 vs. F8: 0.75 ± 0.07*) were found. Plasma ANP decrease (ng/ml: C8: 1.61 ± 0.10 vs. F8: 1.30 ± 0.08*; C12: 1.65 ± 0.32 vs. F12: 1.04 ± 0.16*) along with a lower NPR-A expression in medulla (C4: 1.00 ± 0.05 vs. F4: 0.81 ± 0.02*; C8: 1.00 ± 0.04 vs. F8: 0.80 ± 0.03*; C12: 1.00 ± 0.03 vs. F12: 0.81 ± 0.01*) were also observed (*p < 0.05, #p < 0.01 vs. C). Conclusions: Fructose overload leads to an increase in the urinary L-dopa/DA index from 4th week of treatment that correlates positively with blood pressure elevation. Furthermore the decrease in the natriuretic systems DA and ANP seems to be related to the physiopathology of hypertension in this model.
Mechanisms that regulate localization of a DNA double-strand break to the nuclear periphery (2009)

DNA double-strand breaks (DSBs) are among the most deleterious forms of DNA lesions in cells. Here we induced site-specific DSBs in yeast cells and monitored chromatin dynamics surrounding the DSB using Chromosome Conformation Capture (3C). We find that formation of a DSB within G1 cells is not sufficient to alter chromosome dynamics. However, DSBs formed within an asynchronous cell population result in large decreases in both intra- and interchromosomal interactions. Using live cell microscopy, we find that changes in chromosome dynamics correlate with relocalization of the DSB to the nuclear periphery. Sequestration to the periphery requires the nuclear envelope protein, Mps3p, and Mps3p-dependent tethering delays recombinational repair of a DSB and enhances gross chromosomal rearrangements. Furthermore, we show that components of the telomerase machinery are recruited to a DSB and that telomerase recruitment is required for its peripheral localization. Based on these findings, we propose that sequestration of unrepaired or slowly repaired DSBs to the nuclear periphery reflects a competition between alternative repair pathways.
Low-Transition Test Pattern Generation for BIST-Based Applications (2008)

A low-transition test pattern generator, called the low-transition linear feedback shift register (LT-LFSR), is proposed to reduce the average and peak power of a circuit during test by reducing the transitions among patterns. Transitions are reduced in two dimensions: 1) between consecutive patterns (fed to a combinational only circuit) and 2) between consecutive bits (sent to a scan chain in a sequential circuit). LT-LFSR is independent of circuit under test and flexible to be used in both BIST and scan-based BIST architectures. The proposed architecture increases the correlation among the patterns generated by LT-LFSR with negligible impact on test length. The experimental results for the ISCAS'85 and '89 benchmarks confirm up to 77 percent and 49 percent reduction in average and peak power, respectively.
Combined Metabolic Activators Improve Cognitive Functions without Altering Motor Scores in Parkinson’s Disease (2021)

ABSTRACT The neuropathologic hallmarks of Parkinson’s disease (PD) are associated with mitochondrial dysfunction and metabolic abnormalities. We have reported that the Combined Metabolic Activators (CMA), consisting of L-serine, nicotinamide riboside, N-acetyl-L-cysteine, and L-carnitine tartrate can be used in treating metabolic abnormalities. These metabolic activators are the precursors of nicotinamide adenine dinucleotide (NAD + ) and glutathione (GSH) and used in activation of mitochondrial and global metabolism. We have performed a placebo-controlled, phase-2 study in Alzheimer’s disease (AD) patients and reported that the cognitive functions in AD patients is significantly improved 29% in the CMA group whereas it is improved only 14% in the placebo group after 84 days of CMA administration. Here, we designed a randomized, double-blinded, placebo-controlled, phase-2 study in PD patients with CMA administration. We found that the cognitive functions in PD patients is significantly improved 21% in the CMA group, whereas it is improved only 11% in the placebo group after 84 days of CMA administration. We also found that the administration of CMA did not affect motor functions in PD patients. We performed a comprehensive multi-omics analysis of plasma proteins and metabolites, and revealed the molecular mechanism associated with the treatment of the patients. In conclusion, our results show that treating PD patients with CMAs leads to enhanced cognitive function, as recently reported in AD patients.
Nanoencapsulation of Calix[4]arene Inclusion Complexes (2007)

A hexameric resorcinarene nanocapsule in wet CDCl3 forms inclusion complexes of calix[4]arene with tetramethylammonium and trimethylsulfoxonium cations to give highly stable Russian-doll-type multicomponent assemblies. The 2D NOESY experiments revealed the size of the assembly, the close proximity of the encapsulated calix[4]arene molecule to the resorcinarene molecules of the capsule, and the inclusion of the tetramethylammonium cation in the calix[4]arene cavity.
Baseline IgG-Fc N-glycosylation profile is associated with long-term outcome in a cohort of early inflammatory arthritis patients (2022)

Pending confirmation of these findings in larger cohorts, IgG glycosylation levels could be used as a prognostic marker in early arthritis, to overcome the limitations of the current prognostic tools.
Antibiotic Resistance – Where are We Going? (2023)

Abstract Introduction of antibiotics into clinical practice is considered as a turning point in medicine resulting in saving millions of lives and allowing for the development of new fields of medicine such as transplantology, neonatology, hematology and many others. From the very beginning, this success was accompanied by the emergence of antibiotic resistant strains with its continuous rise. Overuse and misuse of antibiotics in medicine, veterinary practice and animal and plant production are the main reasons the resistance has emerged. Presently, an increase in isolation of multidrug resistant (MDR), excessively resistant (XDR) and pandrug resistant (PDR) bacteria is being observed worldwide in the most common human etiologic bacterial agents . As examples of rapid evolution of resistance, S. aureus and Enterobacterales producing extended-spectrum beta-lactamases are presented. Some initiatives of WHO and EU aiming to tackle antibiotic resistance are also discussed.
ChemInform Abstract: Synthetic Studies on Cell‐Surface Glycans. Part 75. Synthesis of Indole Oxazolines. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Simulation and robust control of power plants (1999)

This paper deals with the analysis and design of controllers for speed control loops. Taking a steam turbine as an example the design of robust control systems and the examination of uncertain plant parameters will be carried out by graphically representing the controller and the plant parameters. The analysis of the plant and the controller design is supported by a power plant simulation system.
Efficient multibeam large-angle nonmechanical laser beam steering from computer-generated holograms rendered on a liquid crystal spatial light modulator (2016)

Multibeam large-angle beam steering is demonstrated in the visible spectral region by imprinting computer-generated holographic Fresnel zone plates on a liquid crystal spatial light modulator (SLM) configured as the first element of a telescope. The position and intensity of each beam are controlled independently. The laser beam is steered over a ±37° field of regard, with the power in the beam at 37° being greater than 50% of the on-axis power. The power delivered on axis for a single beam was 48% of the power incident on the SLM. The beam profile remained Gaussian over the full steering range, and the on-axis beam divergence is 2.1 mrad.
Melanocytoma of the Optic Nerve Associated With Sound-Induced Phosphenes (2006)

Melanocytomas of the optic disc are benign tumors that most often remain asymptomatic and stable in size. However, these tumors can occasionally result in severe vision loss. One such case is described herein with the unusual associated symptom of sound-induced phosphenes.
Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis (2022)

Idiopathic pulmonary fibrosis (IPF) is a fatal disease with limited treatment options. In this study, we focus on the properties of airway basal cells (ABC) obtained from patients with IPF (IPF-ABC). Single cell RNA sequencing (scRNAseq) of bronchial brushes revealed extensive reprogramming of IPF-ABC towards a KRT17<sup>high</sup> PTEN<sup>low</sup> dedifferentiated cell type. In the 3D organoid model, compared to ABC obtained from healthy volunteers, IPF-ABC give rise to more bronchospheres, de novo bronchial structures resembling lung developmental processes, induce fibroblast proliferation and extracellular matrix deposition in co-culture. Intratracheal application of IPF-ABC into minimally injured lungs of Rag2<sup>-/-</sup> or NRG mice causes severe fibrosis, remodeling of the alveolar compartment, and formation of honeycomb cyst-like structures. Connectivity MAP analysis of scRNAseq of bronchial brushings suggested that gene expression changes in IPF-ABC can be reversed by SRC inhibition. After demonstrating enhanced SRC expression and activity in these cells, and in IPF lungs, we tested the effects of saracatinib, a potent SRC inhibitor previously studied in humans. We demonstrate that saracatinib modified in-vitro and in-vivo the profibrotic changes observed in our 3D culture system and novel mouse xenograft model.