gebhart/patrepeval huggingface dataset:
Effects of Core Instability Strength Training on Trunk Muscle Strength, Spinal Mobility, Dynamic Balance and Functional Mobility in Older Adults (2012)

CIT proved to be a feasible exercise program for seniors with a high adherence rate. Age-related deficits in measures of trunk muscle strength, spinal mobility, dynamic balance and functional mobility can be mitigated by CIT. This training regimen could be used as an adjunct or even alternative to traditional balance and/or resistance training.
Analysis of the parasitic forces and torques in coreless linear motors (2011)

This paper concerns the analysis of parasitic forces and torques in coreless or air-cored linear synchronous motors with a U-shaped stator due to variation of the permanent magnet properties, manufacturing tolerances and power amplifier offsets. The parasitic forces and torques are analyzed using a 3D semi-analytical model based on surface charge modeling of the permanent magnets and numerical integration of the Lorentz force. Monte-Carlo simulations have been applied to carry out the tolerance analysis. Gaussian distributions of the tolerances are assumed. The paper shows that variation of the magnet properties, incorrect mounting of the translator and offsets in power amplifiers are the main cause of parasitic forces in this type of linear motors.
Vers les analogues sulfurés d'alcaloïdes indoliques\n\t\t\t : synthèse et réactivité dans la série des thiéno (2,3-b) pyrroles (1977)

Not available
Toverend Trotskisme, de hype van verandering in de sociale sector (2009)

Public funding for research on the action of drugs in countries like the United States requires that racial classification of research subjects should be considered when defining the composition of the samples as well as in data analysis, sometimes resulting in interpretations that Whites and Blacks differ in their pharmacogenetic profiles. In Brazil, pharmacogenomic results have led to very different interpretations when compared with those obtained in the United States. This is explained as deriving from the genomic heterogeneity of the Brazilian population. This article argues that in the evolving field of pharmacogenomics research in Brazil there is simultaneously both an incorporation and rejection of the US informed race-genes paradigm. We suggest that this must be understood in relation to continuities with national and transnational history of genetic research in Brazil, a differently situated politics of Brazilian public health and the ongoing valorization of miscegenation or race mixture by Brazilian geneticists as a resource for transnational genetic research. Our data derive from anthropological investigation conducted in INCA (Brazilian National Cancer Institute), in Rio de Janeiro, with a focus on the drug warfarin. The criticism of Brazilian scientists regarding the uses of racial categorization includes a revision of mathematical algorithms for drug dosage widely used in clinical procedures around the world. Our analysis reveals how the incorporation of ideas of racial purity and admixture, as it relates to the efficacy of drugs, touches on issues related to the possibility of application of pharmaceutical technologies on a global scale.
Analysis of electron injection in laser wakefield acceleration using betatron emission in capillary tubes (2015)

The dynamics of ionization-induced electron injection in the high density (~ 1:2 &times; 10<sup>19</sup>cm<sup>-3</sup>) regime of Laser Wakefield Acceleration (LWFA) was investigated by analyzing betatron X-ray emission inside dielectric capillary tubes. A comparative study of the electron and betatron X-ray properties was performed for both self-injection and ionization-induced injection. Direct experimental evidence of early onset of ionization-induced injection into the plasma wave was obtained by mapping the X-ray emission zone inside the plasma. Particle-In-Cell (PIC) simulations showed that the early onset of ionization-induced injection, due to its lower trapping threshold, suppresses self-injection of electrons. An increase of X-ray fluence by at least a factor of two was observed in the case of ionization-induced injection due to an increased trapped charge compared to self-injection mechanism.
P273 Chemogenetic analysis of how receptors for short chain fatty acids regulate the gut-brain axis (2021)

<h3>Introduction</h3> Short chain fatty acids are produced mainly by the gut microbiota. They mediate a variety of biological effects by acting on a two of G protein-coupled receptors. These receptors are expressed by various cell types, including in the gut. The exact contribution of free fatty acid 2 receptor (FFA2) in regulating gut physiology is unclear. Bolognini et al<sup>1</sup>, recently employed a novel FFA2-Designer Receptor Exclusively Activated by Designer Drugs (DREADD) to study the physiological role of FFA2. Now we describe and further explore the physiological roles of FFA2 with a novel agonist, 4-methoxy-3-methyl-benzoic acid (MOMBA) for the FFA2-DREADD variant following transgenic expression in mice. <h3>Methods</h3> Following an extensive screening of more than 1200 small molecules, MOMBA was identified as a potential agonist for the hFFAR2-DREADD receptor. <b>(1)</b> The selectivity of MOMBA was assesses with β-arrestin-2 recruitment assay in HEK293 cells expressing hFFA2-DREADD and hFFA2-eYFP. The effect of FFA2 activation on the release of enteroendocrine hormones (GLP-1 and PYY) was assessed on <b>(2)</b> isolated crypts and <b>(3)</b> intact colonic segments. Isolated crypts and intact colon segments were challenged with different test compound. Supernatants were subsequently collected and GLP-1 and PYY concentration was measured by ELISA. <b>(4)</b> Furthermore, role of FFA2 in sensory signalling was investigated by measuring intracellular calcium [<sub>i</sub>Ca<sup>2+</sup>] in isolated nodose ganglion (NG) and dorsal root ganglion (DRG). <h3>Results</h3> <b>(1)</b> MOMBA is selective for hFFA2-DREAD <b>(2)</b> MOMBA (1mM-0.001mM) induces a FFA2 specific concentration dependent increase in GLP-1 secretion in colonic crypts. <b>(3)</b> Intraluminal infusion of MOMBA also resulted in a FFA2 mediated increase in GLP-1 and PYY secretion from intact colon. Furthermore, <b>(4)</b> MOMBA induced a G<sub>q</sub> mediated increase in [<sub>i</sub>Ca<sup>2+</sup>] in cells isolated from DREADD mice. Conversely, C3 induced a G<sub>i</sub> mediated increase in these cells. <h3>Conclusion</h3> MOMBA specifically activates hFFA2-DREADD, hence providing a novel tool ligand to further study the physiological and pathophysiological roles of FFA2 within the gut, as well as other cell types that express this receptor.
Terahertz Multi-Chip Module (T-MCM) technology for the 21st century? (1998)

This paper describes a new philosophy for realising terahertz MCMs, that can operate within the frequency range of approximately 75 to 300 GHz, which are not only manufacturable but can also provide state-of-the-art performance. To this end, a consortium of four leading UK universities has recently been formed to demonstrate this T-MCM technology. Some of the techniques that will be under investigation within this ambitious three-year research programme are presented here. The ultimate goal is to provide industry with a technology that will allow them, for the first time, to realise complete terahertz sub-systems without the need for bulky and expensive superconducting and machined waveguide components.
Adsorption States of Amphipatic Solutes at the Surface of Naturally Hydrophobic Minerals:  A Molecular Dynamics Simulation Study (2007)

An initial molecular dynamics simulation study regarding interfacial phenomena at selected naturally hydrophobic surfaces is reported. Simulation results show that, due to the natural hydrophobicity of graphite and talc basal planes, the cationic surfactant dodecyltrimethylammonium bromide preferentially adsorbs at these surfaces through hydrophobic interactions. When a model dextrin molecule is considered, the simulation results suggest that the hydrophobic interaction between the naturally hydrophobic surfaces of graphite, talc basal plane, and sulfur and the hydrophobic moieties (C-H and methylene groups) in the dextrin molecule plays a significant role in dextrin adsorption at these surfaces. The hydroxyl group in the dextrin molecule also contributes to its adsorption at the talc basal plane surface. In contrast, dextrin was not found to adsorb at talc edge surfaces.
Ethanol production using a newly isolated <i><scp>S</scp>accharomyces cerevisiae</i> strain directly assimilating intact inulin with a high degree of polymerization (2013)

An inulin-degrading strain L610, which was competent to directly convert inulin into ethanol, was isolated and identified as a strain of Saccharomyces cerevisiae according to physiological and phylogenetic analysis. Ion chromatography results showed that isolate L610 could assimilate the intact inulin completely without acidic or enzymatic pretreatment in contrast to the previously reported strains of S. cerevisiae, which could only ferment the fructo-oligosaccharides with a degree of polymerization less than 15. Strain L610 yielded 37.2 g/L ethanol within 48 H at a shake flask level under the evaluated culture conditions (11% inulin, 0.4% yeast extract, and 0.05% MgSO4 at 30 °C and pH 6.0). The conversion efficiency of inulin-type sugar to ethanol was 60% of the theoretical ethanol yield. Strain L610 produced 40.0 g/L of ethanol when directly fermented in Jerusalem artichoke (Helianthus tuberosus L.) powder suspension within 24 H, which was higher than the reported data, 28.9 g/L, produced by S. cerevisiae KCCM 50549.
MEASUREMENT OF TUMOR HYPOXIA IN SPONTANEOUS CANINE SARCOMAS (2005)

We used positron emission tomography (PET) with [18F]fluoromisonidazole ([18F]FMISO) to study tumor hypoxia in six dogs with spontaneous sarcomas. The tumors were regarded as hypoxic if [18F]FMISO uptake exceeded normal tissue radioactivity by 40% (tumor/muscle ratio > 1.4) or if kinetic analysis indicated a positive [18F]FMISO tissue influx rate (Ki > 0) by a Patlak plot. Using these criteria, we found hypoxia in a fibrosarcoma grade II, an undifferentiated sarcoma, and an ostoeosarcoma, but not in a fibrosarcoma grade I, another osteosarcoma, and a myxosarcoma. In three animals, the tumor oxygen partial pressure (pO2) was also measured invasively using Eppendorf needle electrodes. In these cases, the Eppendorf measurements were confirmed by the [18F]FMISO PET results. In addition, [15O]H2O PET was performed in four dogs in order to assess tumor perfusion. Comparisons of the [18F]FMISO with [15O]H2O PET images in two cases showed that tumor hypoxia occurred in the tumor center with low perfusion, whereas perfusion was heterogeneous in a nonhypoxic tumor.
Virtual ventriculostomy with 'shifted ventricle': neurosurgery resident surgical skill assessment using a high-fidelity haptic/graphic virtual reality simulator (2009)

Based on a study of 48 neurological residents using a high fidelity haptic/graphic virtual reality simulator to perform ventricular cannulation, we recorded absolute Euclidean distance from the catheter tip to the foramen of Monroe within the ventricle. The data suggest that as expected, successful first attempts to cannulate the virtual 'shifted ventricle' are much less frequent than previous assessments with normal virtual ventricular anatomy. Furthermore, the significant improvement observed by the second attempt implies that the learning curve has been affected and the process 'jump started'.
Glycoconjugate vaccines and immune interactions, and implications for vaccination schedules (2011)

Conjugate vaccines using diphtheria toxoid variant (CRM(197)), diphtheria toxoid and tetanus toxoid (TT) as carrier protein may induce immune interactions (interference or impairment as measured by lower antibody levels, or enhancement [higher antibody levels]) when coadministered with other vaccines. Immune enhancement occurs when two TT conjugates are coadministered. CRM(197) conjugate vaccines induce immune bystander interference when given with diphtheria-tetanus-acellular pertussis vaccines, which reduces responses to coadministered Haemophilus influenzae type b vaccine conjugated to TT. These bystander effects are greater as the amount of CRM(197) administered increases. When large amounts of either TT or CRM(197) are coadministered, dose-related carrier-induced epitopic suppression may occur, affecting immune responses to meningococcal or pneumococcal polysaccharides. These observations have implications for vaccine scheduling. The range of available alternative vaccines means that specific vaccine coadministrations can avoid or reduce CRM(197)-induced interference. Potential interactions arising from new CRM(197) or TT conjugates will need to be thoroughly examined.
Control of pro-atherogenic TNFα production through nuclear receptor co-factor RIP140 (2006)

Accelerated atherosclerosis represents a hallmark of the metabolic syndrome as observed in insulin-restistant patients. Defects in lipid and cytokine metabolism in macrophages are critically linked to the initiation and progression of atherosclerosis. Given the importance for atherosclerotic lesion development during insulin resistance, this study aimed to explore the transcriptional regulation of pro-inflammatory cytokine production in macrophages. We were able to show that nuclear receptor co-factor RIP140 enhances cytokine tumor necrosis factor (TNF)α gene activity upon lipopolysaccharide (LPS)-mediated macrophage activation. This effect was shown to be conferred via the LPS responsive TNFα promoter region. Indeed, RIP140 was recruited to the endogenous TNFα promoter in a LPS-dependent manner. Co-immunoprecipitation studies revealed that RIP140 interacted with the LPS-inducible transcription factor c-Jun in macrophages in vivo. To this end, mutation of the c-Jun binding site reduced the induction of TNFα through RIP140 in transcriptional activation studies. As RIP140-mediated TNFα gene expression was also translated into strongly potentiated TNFα release from macrophages, these results support the idea that RIP140 controls parts of the inflammatory response of macrophages. Therefore, interference with RIP140 activity might be a potential new strategy for the development of anti-atherogenic drugs in the treatment of the metabolic syndrome.
Real Time Identification of Drug-Induced Liver Injury (DILI) through Daily Screening of ALT Results: A Prospective Pilot Cohort Study (2012)

A simple strategy based on the daily analysis of cases with ALT >3 ULN by designated biochemists and hepatologists identified 12 times more acute cases of drug-induced liver disease than the standard strategy. This pilot cohort is registered on the number AP-HP P110201/1/08-03-2011 and AFSSAPS B110346-70.
ChemInform Abstract: Imidic Acid Derivatives in the Synthesis of 1,3‐Diazines (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dynamic throughput optimization in SCTP (2015)

The Stream Control Transmission Protocol (SCTP) is a relatively new transport protocol. It has several underlying mechanisms that are similar to the Transmission Control Protocol (TCP), as well as several improvements that are important in certain classes of applications. The timeout scheme of SCTP, however, is almost identical to that used in TCP. With dynamics of today's Internet, that timeout scheme may be too passive. This paper presents an algorithm which dynamically adjusts the overall context of the retransmission timeout process without changing the fundamental retransmission mechanisms. This approach manages the impact of fast retransmissions and timeouts to significantly improve the throughput of SCTP applications. The algorithm avoids spurious retransmissions and provides better throughput by intelligently managing RTO boundaries and allowing conventional timeout schemes to participate more actively in the retransmission process.
Optical Fiber Amplifiers and Their Applications. Optical Cable Amplifier. (1997)

An erbium-doped fiber amplifier installed inside an optical fiber cable is reported. This optical cable amplifier is mechanically flexible as the result of using a flexible stainless steel tube and wire mesh as the amplifier cavity and outer cover, respectively. The amplifier is pumped with a 0.98μm laser diode to reduce both the electric driving power and the wavelength dependence of optical gain. Backward pumping is used to obtain a high optical output power. A gain of 27.5dB and a maximum optical output power of + 10dBm have been successfully realized. The wavelength dependence of the optical gain was 2.1dB between 1540nm and 1560nm. A two-channel optical cable amplifier with two EDFAs in the cable is also described. The noise figure of the amplifiers was approximately 6dB and the output power dependence on ambient temperature change was less than ±0.2dB between 20°C and 60°C.
Overview of ImageCLEF Lifelog 2020: Lifelog Moment Retrieval and Sport Performance Lifelog (2020)

This paper describes the fourth edition of Lifelog challenges in ImageCLEF 2020. In this edition, the Lifelog challenges consist of two tasks which are Lifelog Moments Retrieval (LMRT) and Sport Performance Lifelog (SPLL). While the Lifelog Moments Retrieval challenge follows the same format of the previous edition, its data is a larger multimodal dataset based on the merger of three previous NTCIR Lifelog datasets, which contain approximately 191,439 images with corresponding visual concepts and other related metadata. The Sport Performance Lifelog, which is a brand new challenge, is composed of three subtasks that focus on predicting the expected performance of athletes who trained for a sport event. In summary, the ImageCLEF Lifelog 2020 receives 50 runs from six teams in total with competitive results.
Accessible information in quantum measurement (1996)

The amount of information that can be accessed via measurement of a quantum system prepared in different states is limited by the Kholevo bound. We present a simple proof of this theorem and its extension to sequential measurements based on the properties of quantum conditional and mutual entropies. The proof relies on a minimal physical model of the measurement which does not assume environmental decoherence, and has an intuitive diagrammatic representation.
Intrathecal Catheter Granuloma with Baclofen Infusion (2006)

To the Editor: Murphy et al. (1) reported a case regarding the development of an intrathecal catheter tip mass after intrathecal baclofen infusion. Others have suggested that granulomas do not occur with isolated intrathecal baclofen infusion (2). Before concluding that intrathecal baclofen infusion may lead to the development of such granulomas, we need to address a few questions. First, the authors reported that the magnetic resonance image (MRI) showed the catheter tip was “occluded” by a fibrous mass consistent with catheter tip-associated granuloma. However, when they interrogated the drug delivery system, it did not reveal any evidence of failure to aspirate or deliver the drug. One would expect a disparity between the volumes of expected drug as calculated versus the volume actually found in the reservoir (3). Second, they performed a catheter myelogram, which excluded catheter migration or leakage. However, they did not comment about encountering increased pressure during injection or increased resistance while aspirating, as one would expect from a catheter that is occluded by a mass. Third, the MRI picture shown in Figure 1 in the report is not convincing. We think it may merely represent a localized inflammatory response resulting from the trauma of repeated catheter implantation, rather than representing a drug-related, catheter-tip granuloma. Fourth, the dose of baclofen was modest, and the duration of the treatment was not long enough to be associated with granuloma formation. Spinal cord injury patients, in contrast to multiple sclerosis patients, require baclofen dose escalation with time. The dose increase in this case was not excessive. Samer N. Narouze, MD, MSc Nagy A. Mekhail, MD, PhD Department of Pain Management Cleveland Clinic Foundation Cleveland, Ohio [email protected]
Caracterización proteómica in vivo de células endoteliales circulantes y células progenitoras de endoteliales an pacientes con síndrome coronario agudo (2012)

Caracterizacion proteomica in vivo de celulas endoteliales circulantes y celulas progenitoras de endoteliales en pacientes con sindrome coronario agudo L. Mourino-Alvarez, E. Calvo, CM. Laborde, S. Alonso-Orgaz, LR. Padial, J. Moreu, JA. Lopez, MG. Barderas, F. Gil-Dones Fisiopatologia Vascular, Hospital Nacional de Paraplejicos, SESCAM, Toledo. Unidad de Proteomica , CNIC, Madrid. 4 Servicio de Cardiologia, Hospital Virgen de la Salud, SESCAM, Toledo
Real-Time Monitoring of Somatostatin Receptor-cAMP Signaling in Live Pituitary (2010)

Fluorescence resonance energy transfer using genetically encoded biosensors has proven to be a powerful technique to monitor the spatiotemporal dynamics of cAMP signals stimulated by G(s)-coupled receptors in living cells. In contrast, real-time imaging of G(i)-mediated cAMP signals under native conditions remains challenging. Here, we describe the use of transgenic mice for cAMP imaging in living pituitary slices and primary pituitary cells. This technique can be widely used to assess the contribution of various pituitary receptors, including individual G(i) protein-coupled somatostatin receptors, to the regulation of cAMP levels under physiologically relevant settings.
Influence of Extruder Conditions on Orientation Distribution in LLDPE Blown Films (1992)

We describe the effect of extruder temperature profiles on melt temperature homogeneity and bubble stability, the effect of melt temperature gradient on the suface temperature variation around the bubble and the effect of surface temperature variation around the bubble gauge and molecular orientation distribution around the film
The oral vaccination with Paenibacillus larvae bacterin can decrease susceptibility to American Foulbrood infection in honey bees—A safety and efficacy study (2022)

biological sciences, applied biological sciences.