gebhart/patrepeval huggingface dataset:
Characterization of centrosomal association of nucleophosmin/B23 linked to Crm1 activity (2005)

Nucleophosmin (NPM)/B23 is a multifunctional protein, involving in a wide variety of basic cellular processes, including ribosome assembly, DNA duplication, nucleocytoplasmic trafficking, and centrosome duplication. It has previously been shown that NPM/B23 localizes to centrosomes, and dissociate from centrosomes upon phosphorylation by Cdk2/cyclin E. However, detail characterization of centrosomal association of NPM/B23 has been hampered by the lack of appropriate antibodies that efficiently detects centrosomally localized NPM/B23, as well as by apparent loss of natural behavior of NPM/B23 when tagged with fluorescent proteins. Here, by the use of newly generated anti-NPM/B23 antibody, we conducted a careful analysis of centrosomal localization of NPM/B23. We found that NPM/B23 localizes between the paired centrioles of unduplicated centrosomes, suggesting the role of NPM/B23 in the centriole pairing. Upon initiation of centrosome duplication, some NPM/B23 proteins remain at mother centrioles of the parental centriole pairs. We further found that inhibition of Crm1 nuclear export receptor results in both accumulation of cyclin E at centrosomes and efficient dissociation of NPM/B23 from centrosomes.
Nonlinear aerodynamic damping of sharp-edged flexible beams oscillating at low Keulegan–Carpenter numbers (2009)

Slender sharp-edged flexible beams such as flapping wings of micro air vehicles (MAVs), piezoelectric fans and insect wings typically oscillate at moderate-to-high values of non-dimensional frequency parameter β with amplitudes as large as their widths resulting in Keulegan–Carpenter ( KC ) numbers of order one. Their oscillations give rise to aerodynamic damping forces which vary nonlinearly with the oscillation amplitude and frequency; in contrast, at infinitesimal KC numbers the fluid damping coefficient is independent of the oscillation amplitude. In this article, we present experimental results to demonstrate the phenomenon of nonlinear aerodynamic damping in slender sharp-edged beams oscillating in surrounding fluid with amplitudes comparable to their widths. Furthermore, we develop a general theory to predict the amplitude and frequency dependence of aerodynamic damping of these beams by coupling the structural motions to an inviscid incompressible fluid. The fluid–structure interaction model developed here accounts for separation of flow and vortex shedding at sharp edges of the beam, and studies vortex-shedding-induced aerodynamic damping in slender sharp-edged beams for different values of the KC number and the frequency parameter β. The predictions of the theoretical model agree well with the experimental results obtained after performing experiments with piezoelectric fans under vacuum and ambient conditions.
Operator Sampling for Shot-frugal Optimization in Variational Algorithms (2020)

Quantum chemistry is a near-term application for quantum computers. This application may be facilitated by variational quantum-classical algorithms (VQCAs), although a concern for VQCAs is the large number of measurements needed for convergence, especially for chemical accuracy. Here we introduce a strategy for reducing the number of measurements (i.e., shots) by randomly sampling operators $h_i$ from the overall Hamiltonian $H = \sum_i c_i h_i$. In particular, we employ weighted sampling, which is important when the $c_i$'s are highly non-uniform, as is typical in chemistry. We integrate this strategy with an adaptive optimizer developed recently by our group to construct an improved optimizer called Rosalin (Random Operator Sampling for Adaptive Learning with Individual Number of shots). Rosalin implements stochastic gradient descent while adapting the shot noise for each partial derivative and randomly assigning the shots amongst the $h_i$ according to a weighted distribution. We implement this and other optimizers to find the ground states of molecules H$_2$, LiH, and BeH$_2$, without and with quantum hardware noise, and Rosalin outperforms other optimizers in most cases.
The Effects of Mindfulness Meditation on Maladjusted Military Soldiers (2013)

Objective: Most Korean men have to serve a year and six months in the army. However, according to a survey on maladjusted military soldiers (2006), 45% of the soldiers feel difficulties in their military life. The Korean Army runs Camp, a two-week group psychological therapy program aimed at helping their adjustment and preventing their suicide. A precedent study showed a significant difference in the scale of clinging and psychological well-being on maladjusted military soldiers. Jeong-Ho, Kim (1994a) said in everyday life we can`t experience phenomenon as it is, but understand it through our prior knowledge and prejudice; mindfulness enables us to understand the phenomenon of mind as it is, not through these. At this point researchers think because maladjusted military soldiers can`t experience psychological problems and situations of military service as they are, but view them by their own fixed recognition frame, their clinging is high. Therefore, this study tried to reduce clinging and foster psychological well-being by having soldiers view their own mind and situation as they are and by cultivating psychological flexibility to understand all the changes through the mindfulness meditation program. Methods: This study was conducted 6 times in all, for 70mins per session, and was aimed at 15 maladjusted military soldiers who entered Green Camp. The program is composed of mindfulness training, daily records, feedback, etc. For the study of the program we conducted the preliminary/posterior inspection of Kentucky Inventory of mindfulness skills (K-KIMS), The Revised Clinging Scale (RCS), and Psychological well-being Scale (PWBS). We verified the effect of the program by using PASW-Statistics18.0. Results: As a measurement result of K-KIMS for investigating the change of mindfulness by program execution, the difference was not significant in statistics. [t=-62, p=.54] And the ante/post-score of clinging was not significant in statistics. [t=.77, p=.45] However, as a result of verification by subordinate factors, clinging for future was reduced significantly. [t=2.21, p<.05] And it was ascertained that psychological well-being showed significant increase.[t=-3.56, p<.05]. As a result of correlation analysis for variation of mindfulness, clinging, and psychological well-being, correlation coefficient between the variations of mindfulness and psychological well-being had a high interrelationship.[r=.58, p<.05] Also, the variations of clinging and psychological well-being had a very high interrelationship.[r=-.72, p<.05]. This suggests that the increase of mindfulness score correlates with the reduction of clinging, and the reduction of clinging has high correlation with the increase of psychological well-being. It is thought that we will need to verify the long-term effect of mindfulness meditation through inspection later on.
Comparative Study on Cu-CVD Nucleation Using β-diketonato and Amidinato Precursors for Sub-10-nm-Thick Continuous Film Growth (2015)

We demonstrate the growth of sub-10-nm-thick continuous Cu films using chemical vapor deposition (CVD) for next-generation Cu interconnects for ultra-large-scale integration (ULSI). The thickness of such films is equivalent to that of Cu during coalescence, and optimized operating conditions and substrate materials are required to form high-density nucleates. Ru was used as an underlayer, and the time evolution of nucleation and grain growth were studied with systematically varied conditions using two Cu precursors: conventional β-diketonato and newly developed amidinato precursor compounds. The revealed geometry of the initial nano-scale Cu grains prior to coalescence suggests the required nucleate density for 7-nm-thick continuous film growth, and which was 2.4 × 1011 /cm2. The maximum nucleate density was achieved with the lowest deposition temperature and highest precursor concentration for both precursors; i.e., 6.9 × 1011 /cm2 for β-diketonato at 100°C, and 4.6 × 1011 /cm2 for amidinato at 150°C. A 10-nm-thick continuous Cu film was formed using amidinato under the optimized conditions. Furthermore, the framework used in this study to enable a high nucleate density suggests that it is possible to form thinner (4 nm∼) Cu films using amidinato. Because of the inherent good step coverage of CVD, this process is a promising candidate for next-generation ULSI Cu interconnects.
Three-Dimensional Graphene-Based Microbarriers for Controlling Release and Reactivity in Colloidal Liquid Phases (2016)

Two-dimensional materials are of great interest as high-performance molecular barriers. Graphene in particular is atomically thin, is impermeable to all molecules, and in some forms can be easily deposited over large areas into planar multilayer films that have been shown to suppress molecular transport. Graphene and graphene oxide sheets are also known to spontaneously self-assemble at liquid-liquid interfaces on the surfaces of dispersed droplets, but much less is known about the barrier properties of these ultrathin films in 3D curved microgeometries. This article demonstrates that 3D films self-assembled from graphene oxide or reduced graphene oxide sheets can be exploited to control the release of small molecules from dispersed liquid phase droplets by evaporation. The release rate and containment time can be tuned by addition of multivalent cations that recruit additional sheets from the bulk liquid to the interface, which is shown by molecular dynamics to occur by an electrostatic bridging mechanism. 3D graphene-based films on droplet surfaces can also be used to control the release and transport of soluble molecules from the droplet to surrounding bulk solvent phases. In some cases, the release can be effectively stopped to produce unique kinetically trapped emulsion phases consisting of two fully miscible but segregated liquids. Finally, interfacial graphene-based films are also shown to control interfacial chemical reaction processes by serving as transport barriers between the phases or by intercepting reactive cross-phase molecular collisions. This reaction control is demonstrated by using 3D graphene-based microbarriers to protect oxidation-sensitive oils from attack by aqueous-phase reactive oxygen species, which is an undesirable pathway implicated in many chemical product degradation and spoilage processes.
The Roles of the Virome in Cancer (2021)

Viral infections as well as changes in the composition of the intestinal microbiota and virome have been linked to cancer. Moreover, the success of cancer immunotherapy with checkpoint inhibitors has been correlated with the intestinal microbial composition of patients. The transfer of feces-which contain mainly bacteria and their viruses (phages)-from immunotherapy responders to non-responders, known as fecal microbiota transplantation (FMT), has been shown to be able to convert some non-responders to responders. Since phages may also increase the response to immunotherapy, for example by inducing T cells cross-reacting with cancer antigens, modulating phage populations may provide a new avenue to improve immunotherapy responsiveness. In this review, we summarize the current knowledge on the human virome and its links to cancer, and discuss the potential utility of bacteriophages in increasing the responder rate for cancer immunotherapy.
Peptide Bond Cleavage by Ni(II) Ions within the Nuclear Localization Signal Sequence (2019)

Nickel is harmful to humans, being both carcinogenic and allergenic. However, the mechanisms of this toxicity are still unresolved. We propose that Ni(II) ions disintegrate proteins by hydrolysis of peptide bonds preceding the Ser/Thr-Xaa-His sequences. Such sequences occur in nuclear localization signals (NLSs) of human phospholipid scramblase 1, Sam68-like mammalian protein 2, and CLK3 kinase. We performed spectroscopic experiments showing that model nonapeptides derived from these NLSs bind Ni(II) at physiological pH. We also proved that these sequences are prone to Ni(II) hydrolysis. Thus, the aforementioned NLSs may be targets for nickel toxicity. This implies that Ni(II) ions disrupt the transport of some proteins from cytoplasm to cell nucleus.
Scavengers for Peroxynitrite: Inhibition of Tyrosine Nitration and Oxidation with Tryptamine Derivatives, .ALPHA.-Lipoic Acid and Synthetic Compounds. (2000)

The inhibitory effects of various endogenous and synthetic compounds on the nitration and oxidation of L-tyrosine by peroxynitrite were examined. Nitrating and oxidizing activities were monitored by the formation of 3-nitrotyrosine and dityrosine with a HPLC-UV-fluorescence detector system, respectively. Glutathione, serotonin and synthetic sulfur- and selenium-containing compounds inhibited both the nitration and oxidation reaction of L-tyrosine effectively. However, 5-methoxytryptamine, melatonin and alpha-lipoic acid only inhibited the nitration reaction, and enhanced the formation of an oxidation product. This is important evidence that there are different intermediates in the nitrating and oxidizing reactions of L-tyrosine by peroxynitrite. It was suggested that 5-methoxytryptamine, melatonin and alpha-lipoic acid reacted only with the nitrating intermediate of peroxynitrite and inhibited nitration of L-tyrosine. Actually, the DNA strand breakage, which is believed to be a typical reaction of hydroxyl radical-like species, caused by peroxynitrite was not effectively inhibited by 5-methoxytryptamine. 5-Methoxytryptamine, melatonin and alpha-lipoic acid were viewed as useful reagents for investigating the mechanisms of damage by peroxynitrite in vitro.
Pathology of macular lesions from subnanosecond pulses of visible laser energy. (1997)

The retinal response to ultrashort laser pulses at moderate energy followed a pattern of focal damage from laser-induced breakdown without significant thermal spread.
Arrayed protein library technology for therapeutic biologic discovery (2012)

The first monoclonal antibody was appproved for human clinical use in 1985. This antibody, OKT3 (Kung et al., 1979), was derived from a mouse hybridoma and produced anti-mouse reactions that limited its use, and hindered further development of monoclonal antibodies. Humanization technology eliminated these cross-species issues and resulted in the approval of the first recombinant “chimeric” antibody rituximab and “humanized” antibody trastuzumab in 1997 and 1998, respectively. The approval of these molecules opened the floodgates for antibody development, as over 20 antibodies are currently approved by the FDA for therapeutic use and hundreds are in clinical development (nelson et al., yEAR?). The need for humanized recombinant antibodies spurred the develoment of several technologies for their discovery and engineering.
Supplementary Figure 2 from Human Monoclonal Antibody Fragments Binding to Insulin-like Growth Factors I and II with Picomolar Affinity (2023)

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Développement d'un modèle ostéoarticulaire du genou humain pour une analyse dynamique du contact en grands déplacements (2011)

National audience
Variants With Different Mutation Patterns Persist in the Quasispecies of Enfuvirtide-Resistant HIV-1 Population During and After Treatment In Vivo (2007)

Individual variability of the mutation pattern and persistence of strains without mutation in the region mainly targeted by ENF resistance probably reflect the fact that resistance to ENF may rely on regions of gp41 or gp120 other than residues 36 to 45.
Content-based rendezvous with upgraph combination (2010)

This short article presents a brief overview of a content-based publish/subscribe rendezvous system that uses up-graphs for determining interdomain-compliant content delivery structures. Upgraphs of subscribers and publishers are combined in order to determine such multicast structures.
hTERT gene expression levels and telomerase activity in drug resistant MCF-7 cells. (2008)

This report demonstrates that drug resistance developed against paclitaxel, docetaxel, vincristine and doxorubicin in MCF-7 cells is independent of the expression of hTERT gene and telomerase activity.
The Effect of the Phase Angle between the Forewing and Hindwing on the Aerodynamic Performance of a Dragonfly-Type Ornithopter (2016)

Dragonflies achieve agile maneuverability by flapping four wings independently. Different phase angles between the flapping forewing and hindwing have been observed during various flight modes. The aerodynamic performance depends on phase angle control, as exemplified by an artificial flying ornithopter. Here, we present a dragonfly-like ornithopter whose phase angle was designed to vary according to the phase lag between the slider-cranks of the forewing and hindwing. Two microelectromechanical systems (MEMS) differential pressure sensors were attached to the center of both forewing and hindwing to evaluate the aerodynamic performance during flapping motions when the phase angle was changed. By varying the phase angle in both the tethered condition and free-flight, the performance of the forewing remained approximately constant, whereas that of the hindwing exhibited obvious variations; the maximum average value was two-fold higher than the minimum. The experimental results suggest that simple phase angle changes enable a flying ornithopter to control flight force balance without complex changes in the wing kinematics.
Introduksjon til analyse av cDNA mikromatrisedata (2009)

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TOTAL QUALITY MANAGEMENT: A COMPUTERIZED SYSTEM (1995)

Krumholz, David M. OD; Adamczyk, Diane T. OD; Nevins, Linda M. RN; Pace, Catherine A. OD Author Information
OBSERVATION OF 23 SUPERNOVAE THAT EXPLODED &lt;300 pc FROM EARTH DURING THE PAST 300 kyr (2014)

Four supernovae (SNe), exploding ⩽300 pc from Earth, were recorded 44, 37, 32, and 22 kyr ago in the radiocarbon (14C) record during the past 50 kyr. Each SN left a nearly identical signature in the record, beginning with an initial sudden increase in atmospheric radiocarbon, when the SN exploded, followed by a hiatus of 1500 yr, and concluding with a sustained 2000 yr increase in global radiocarbon due to γ-rays produced by diffusive shock in the SN remnant (SNR). For the past 18 kyr excess radiocarbon has decayed with the 14C half-life. SN22kyrBP, is identified as the Vela SN that exploded 250 ± 30 pc from Earth. These SN are confirmed in the 10Be, 26Al, 36Cl, and NO geologic records. The rate of near-Earth SNe is consistent with the observed rate of historical SNe giving a galactic rate of 14 ± 3 kyr−1 assuming the Chandra Galactic Catalog SNR distribution. The Earth has been used as a calorimeter to determine that ≈2 × 1049 erg were released as γ-rays at the time of each SN explosion and ≈1050 erg in γ-rays following each SN. The background rate of 14C production by cosmic rays has been determined as 1.61 atoms cm−2 s−1. Approximately 1/3 of the cosmic ray energy produced by diffusive shock in the SNR was observed to be emitted as high-energy γ-rays. Analysis of the 10Be/9Be ratio in marine sediment identified 19 additional near-Earth SNe that exploded 50–300 kyr ago. Comparison of the radiocarbon record with global temperature variations indicated that each SN explosion is correlated with a concurrent global warming of ≈3°C–4°C.
ChemInform Abstract: Allyl Amines as Ammonia Equivalents in the Preparation of Anilines and Heteroarylamines. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Acute Kidney Injury (2016)

Acute kidney injury (AKI) is a global public health concern associated with high morbidity, mortality, and healthcare costs. Other than dialysis, no therapeutic interventions reliably improve survival, limit injury, or speed recovery. Despite recognized shortcomings of in vivo animal models, the underlying pathophysiology of AKI and its consequence, chronic kidney disease (CKD), is rich with biological targets. We review recent findings relating to the renal vasculature and cellular stress responses, primarily the intersection of the unfolded protein response, mitochondrial dysfunction, autophagy, and the innate immune response. Maladaptive repair mechanisms that persist following the acute phase promote inflammation and fibrosis in the chronic phase. Here macrophages, growth-arrested tubular epithelial cells, the endothelium, and surrounding pericytes are key players in the progression to chronic disease. Better understanding of these complex interacting pathophysiological mechanisms, their relative importance in humans, and the utility of biomarkers will lead to therapeutic strategies to prevent and treat AKI or impede progression to CKD or end-stage renal disease (ESRD).
Dominant Activity of Activation Function 1 (AF-1) and Differential Stoichiometric Requirements for AF-1 and -2 in the Estrogen Receptor α-β Heterodimeric Complex (1999)

Estrogenic responses are now known to be mediated by two forms of estrogen receptors (ER), ERalpha and ERbeta, that can function as homodimers or heterodimers. As homodimers the two have been recently shown to exhibit distinct transcriptional responses to estradiol (E2), antiestrogens, and coactivators, suggesting that the ER complexes are not functionally equivalent. However, because the three possible configurations of ER complexes all recognize the same estrogen response element, it has not been possible to evaluate the transcriptional properties of the ER heterodimer complex by transfection assays. Using ER subunits with modified DNA recognition specificity, we were able to measure the transcriptional properties of ERalpha-ERbeta heterodimers in transfected cells without interference from the two ER homodimer complexes. We first demonstrated that the individual activation function 1 (AF-1) domains act in a dominant manner within the ERalpha-ERbeta heterodimer: the mixed agonist-antagonist 4-hydroxytamoxifen acts as an agonist in a promoter- and cell context-dependent manner via the ERalpha AF-1, while activation of the complex by the mitogen-activated protein kinase (MAPK) pathway requires only the ERalpha- or ERbeta-responsive MAPK site. Using ligand-binding and AF-2-defective mutants, we further demonstrated that while the ERalpha-ERbeta heterodimer can be activated when only one E2-binding competent partner is present per dimer, two functional AF-2 domains are required for transcriptional activity. Taken together, the results of this study of a retinoid X receptor-independent heterodimer complex, the first such study, provide evidence of different stoichiometric requirements for AF-1 and -2 activity and demonstrate that AF-1 receptor-specific properties are maintained within the ERalpha-ERbeta heterodimer.
Physical heart in a virtual body (2009)

In this video we present a special guitar that combines physical acoustic properties with virtual capabilities. A wooden resonator - a unique, replaceable piece of wood that gives the guitar a unique acoustic sound, will embody the acoustical values. The acoustic signal created by this wooden heart will be digitally processed in a virtual sound box in order to create flexible sound design. The project shows that traditional values can be embedded into a digital object.