gebhart/patrepeval huggingface dataset:
Calculating the Influence of Tagging People on Sentiment Analysis (2018)

Social media makes it possible for anyone to share and transmit their opinions and sentiments to the rest of the world via the Internet. Recently, sentiment analysis is being used to investigate the opinions posted on Online Social Networks(OSN) based on multiple inputs, such as user profile characteristics, slang, emoticons, among others. However, the current sentiment analysis tools do not consider the influence of tagging people on OSN. In this context, this paper analyzes the impact of the tagging parameter on the global sentiment score of a text. The experimental results of subjective tests show that a correction factor must be considered in case of tagging people. Experimental results demonstrate that the tagging parameter affects the sentiment intensity value, in different ways, depending on the gender of the person who wrote the text and the sentiment polarity of the text. The new sentiment intensity metric considering the tagging people parameter reaches a Pearson Correlation Coefficient of 0.93 and a maximum error of 0.07, for texts of negative polarity written by women, at a 5-point scale. Furthermore, a mobile application with the new sentiment metric, which considers the tagging parameter, is built.
ParGAL: A Scalable Grid-Aware Analysis Library for Ultra Large Datasets. (2012)

Many fields that employ computation require extensive analysis of the output from a petascale simulation of a grid(or mesh)-based application in order to complete their scientific goals or produce a visual image or animation. Often this analysis cannot be done in-situ because it requires calculating time-series statistics from state sampled over the entire length of the run or analyzing the relationship between similar time series from previous simulations or observations. The programs that perform this analysis are not nearly as flexible in their choice of grids or as high-performing as the primary applications. We will describe a new Parallel Gridded Analysis Library (ParGAL) that performs data-parallel versions of several common analysis algorithms on data from a structured or unstructured grid simulation. The library builds on several scalable systems starting with the Mesh Oriented DataBase (MOAB). MOAB is a library for representing mesh data that supports structured, unstructured finite element and polyhedral grids and also supports parallel operations on those grids including loading to and from disk using parallel I/O. We are using the Parallel-NetCDF (PNetCDF) library to perform parallel I/O operations between the popular NetCDF format and ParGAL. Finally, we also make use of Intrepid, an extensible library for computing operators (such as gradient, curl, divergence, etc.) acting on discretized fields. The design and performance of ParGAL will be described and an example of its application to climate compared to a widely used tool is given.
Synthesis and Biological Evaluation of Novel N-phenyl-5-carboxamidyl Isoxazoles as Potential Chemotherapeutic Agents for Colon Cancer (2012)

A new series of isoxazole derivatives, <i>N</i>-phenyl-5-carboxamidyl isoxazoles, was investigated for their anticancer activity with solid tumor selectivity. Six <i>N</i>-phenyl-5-carboxamidylisoxazoles were chemically synthesized and evaluated by the <i>in vitro</i> disk-diffusion assay and IC<sub>50</sub> cytotoxicity determination. The results showed that one of the derivatives, compound <b>3,</b><i>N</i>-(4-chlorophenyl)-5-carboxamidyl isoxazole, was the most active against colon 38 and CT-26 mouse colon tumor cells with an IC<sub>50</sub> of 2.5 μg/mL for both cell lines. Western blot analysis showed that compound <b>3</b> significantly down-regulated the expression of phosphorylated STAT3 in both human and mouse colon cancer cells indicating that the mechanism of action for compound <b>3</b> may involve the inhibition of JAK3/STAT3 signaling pathways. Flow cytometric analysis with Annexin V staining showed that the death induced by compound <b>3</b> is mediated through cell necrosis and not apoptotic pathway. In summary, our results show that compound <b>3</b> is a new <i>N</i>-phenyl-5-carboxamidyl isoxazole with potential anticancer activity. Compound <b>3</b> inhibits the phosphorylation of STAT3, a novel target for chemotherapeutic drugs, and is worthy of further investigation as a potential chemotherapeutic agent for treating colon cancer.
Abstract 6: The Effect of Vascular Amyloid on White Matter Disease is Mediated by Vascular Dysfunction in Cerebral Amyloid Angiopathy (2021)

Background: Cerebral amyloid angiopathy (CAA) is associated with white matter hyperintensities (WMH) but the physiopathological mechanisms remain unclear. We hypothesized that the relationship between vascular amyloid load and WMH is mediated by vascular dysfunction. Methods: The study cohort included 38 non-demented probable CAA patients who underwent advanced multimodal structural and functional MRI (fMRI) and amyloid PET scans. White matter hyperintensity volume was quantified using FreeSurfer and expressed as a percent of total intracranial volume (pWMHv). Time-to-peak [TTP] of blood oxygen level-dependent [BOLD] response to visual stimulation using fMRI was used as an established measure of vascular dysfunction. Mean cortical Pittsburg Compound B uptake representing amyloid load was calculated. A bootstrapping procedure was used to test the mediation hypothesis adjusting for age, sex, and presence of intracerebral hemorrhage (ICH). Results: Of 38 patients with CAA (mean age 70±7.1, 86.8% male), 25 (65.8%) had ICH, while the remaining 13 patients (34.2%) presented with multiple strictly cortical microbleeds. Higher amyloid load correlated with prolonged TTP response (r=0.373, p=0.021) and higher pWMHv (r=0.337, p=0.039), and prolonged TTP response correlated with higher pWMHv (r=0.485, p=0.002). Amyloid load no longer predicted pWMHv (p=0.254) after controlling for TTP. In the bootstrapping model, TTP response had a significant indirect effect (ab=0.977, 95% CI: 0.15-2.42), showing that the association between amyloid load and pWMHv is mediated by TTP. Discussion: Our findings confirm the hypothesis that the effect of vascular amyloid load on the extent of white matter disease is mediated by vascular dysfunction in patients with CAA. Amyloid lowering strategies might prevent pathophysiological processes leading to vascular dysfunction, therefore limiting ischemic brain injury.
Experience with HSP90 inhibitor AUY922 in patients with relapsed or refractory non-Hodgkin lymphoma (2015)

Heat shock protein 90 (HSP90) plays an important role in normal and malignant cells by stabilizing chaperone proteins. It is frequently overexpressed in lymphoma, is known to contribute to the stability of oncoproteins and is thus an attractive target of treatment.[1][1] While first generation HSP90
A Multi-Agent Service Framework for Context-Aware Elder Care (2006)

Advances in healthcare have led to longer life expectancy and the so-called aging population trend. The cost of caring for the elderly is rising progressively and threatens the economic well-being of many nations around the world. Instead of professional nursing facilities, many elderly people prefer living in their own homes independently. To enable successful aging in place, this research explores the roles of technology in improving the quality of life while reducing the cost of healthcare to the elder population. In particular, we propose a multi-agent service framework, called Context-Aware Service Integration System (CASIS), to integrate event-driven services with the OSGi service platform. This paper presents several context-aware service scenarios that have been developed on the proposed framework to demonstrate how context technologies and mobile web services can help enhance the quality of care for an elder&amp;apos;s daily life.
Sequence alterations in RX in patients with microphthalmia, anophthalmia, and coloboma. (2009)

Sequence variations in RX are uncommon in patients with congenital ocular malformations, but may play a role in disease pathogenesis. We observed a missense mutation in RX in a patient with a small, typical chorioretinal coloboma, and postulate that the mutation is responsible for the patient's phenotype.
Fetal hematopoietic stem cell homing is controlled by VEGF regulating the integrity and oxidative status of the stromal-vascular bone marrow niches (2021)

Hematopoietic stem and progenitor cell (HSPC) engraftment after transplantation during anticancer treatment depends on support from the recipient bone marrow (BM) microenvironment. Here, by studying physiological homing of fetal HSPCs, we show the critical requirement of balanced local crosstalk within the skeletal niche for successful HSPC settlement in BM. Transgene-induced overproduction of vascular endothelial growth factor (VEGF) by osteoprogenitor cells elicits stromal and endothelial hyperactivation, profoundly impacting the stromal-vessel interface and vascular architecture. Concomitantly, HSPC homing and survival are drastically impaired. Transcriptome profiling, flow cytometry, and high-resolution imaging indicate alterations in perivascular and endothelial cell characteristics, vascular function and cellular metabolism, associated with increased oxidative stress within the VEGF-enriched BM environment. Thus, developmental HSPC homing to bone is controlled by local stromal-vascular integrity and the oxidative-metabolic status of the recipient milieu. Interestingly, irradiation of adult mice also induces stromal VEGF expression and similar osteo-angiogenic niche changes, underscoring that our findings may contribute targets for improving stem cell therapies.
Development of a Practical Synthesis of Naphthyridone p38 MAP Kinase Inhibitor MK‐0913 (2003)

Naphthyridone p38 mitogen-activated protein (MAP) kinases are intracellular soluble serine/ threonine kinases that positively regulate the production and action of several proinflammatory mediators. Medicinal chemistry synthesis of p38 MAP kinase inhibitor MK-0913 involved an 18-step synthetic procedure in its longest linear sequence with an overall yield ∼2%. Naphthyridones bearing the appropriate substituents could be constructed from aniline and acetonedicarboxylate (ADC) or by the recently discovered tandem Heck—lactamization process from acrylamide and trihalopyridine. The ADC route to chloronaphthyridone began with the monoamidation of ADC with p-methoxybenzylamine through enolate that provided a way to differentiate the two esters. To complete the synthesis of chloronaphthyridone, a regioselective Suzuki-Miyaura coupling of tetrachloronaphthyridone with 2,4-difluorophenylboronic acid was explored. With both Grignard reagent and naphthyridones and chloronaphthyridone in hand, the authors proceeded to study the coupling reactions. Utilizing this chemistry, kilograms of crystalline MK-0913 were successfully manufactured.
Reference sensor selection for automotive active noise control applications (1995)

BBN has obtained a comprehensive set of road noise measurements for the purpose of investigating the potential performance of an automotive active noise control application. Measurements were collected over a total of 20 reference sensors on or near the suspension and four residual sensors in the cabin. Analysis shows that while the reference sensors can account for much of what is received at the microphones, some of the reference sensors provide more residual information than others. For control applications the optimum reference sensors for the available number of input channels are desired. Two reference sensor performance metrics are compared. The first is a suboptimal greedy algorithm where reference channels are iteratively selected via an orthogonalization procedure. The second technique is an exhaustive search over candidate reference sensors sets where the coherent power is maximized. Results show that the greedy procedure generally identifies the majority of the sensors shown to be optimum through the exhaustive search. [Work supported by ARPA.]
Bacterial community of sediments under the Eastern Boundary Current System shows high microdiversity and a latitudinal spatial pattern (2022)

The sediments under the Oxygen Minimum Zone of the Eastern Boundary Current System (EBCS) along Central-South Peru and North-Central Chile, known as Humboldt Sulfuretum (HS), is an organic-matter-rich benthic habitat, where bacteria process a variety of sulfur compounds under low dissolved-oxygen concentrations, and high sulfide and nitrate levels. This study addressed the structure, diversity and spatial distribution patterns of the HS bacterial community along Northern and South-Central Chile using 16S rRNA gene amplicon sequencing. The results show that during the field study period, the community was dominated by sulfur-associated bacteria. Indeed, the most abundant phylum was <i>Desulfobacterota</i>, while Sva0081 sedimentary group, of the family <i>Desulfosarcinaceae</i> (the most abundant family), which includes sulfate-reducer and H<sub>2</sub> scavenger bacteria, was the most abundant genus. Furthermore, a spatial pattern was unveiled along the study area to which the family <i>Desulfobulbaceae</i> contributed the most to the spatial variance, which encompasses 42 uncharacterized amplicon sequence variants (ASVs), three assigned to <i>Ca</i>. Electrothrix and two to <i>Desulfobulbus</i>. Moreover, a very high microdiversity was found, since only 3.7% of the ASVs were shared among localities, reflecting a highly diverse and mature community.
Green synthesis, characterization and bioactivity evaluation of Caesium carbonate nanoparticle using Coleus amboinicus (2022)

Abstract The authors have requested that this preprint be removed from Research Square.
Design of rigidity and breaking strain on stretchable electronic substrate with Kirigami structure (2019)

We have modeled Kirigami structure in order to theoretically design rigidity and breaking strain as a device by changing parameters of Kirigami structure. Kirigami structure can change the rigidity and breaking strain as a device by change the dimensional parameter of Kirigami structure. However, the relationship between the dimensional parameters of Kirigami structure and mechanical characteristics such as rigidity and breaking strain as a device has only experimentally clarified. Therefore, we clarified the relationship between the dimensional parameters of Kirigami structure and the rigidity and breaking strain as a device by modeling Kirigami structure. We compared the value derived from the model and measured values calculated by the tensile test in order to investigate whether the model can be applied to the Kirigami structure. As the comparison result was in good agreement, the result indicates that the model can be applied to the Kirigami structure.
A Scalable Services Architecture (2006)

Data centers constructed as clusters of inexpensive machines have compelling cost-performance benefits, but developing services to run on them can be challenging. This paper reports on a new framework, the scalable services architecture (SSA), which helps developers develop scalable clustered applications. The work is focused on non-transactional high-performance applications; these are poorly supported in existing platforms. A primary goal was to keep the SSA as small and simple as possible. Key elements include a TCP-based "chain replication" mechanism and a gossip-based subsystem for managing configuration data and repairing inconsistencies after faults. Our experimental results confirm the effectiveness of the approach
Release of crowding by pattern completion (2015)

In crowding, target perception deteriorates in the presence of flanking elements. Crowding is classically explained by low-level mechanisms such as pooling or feature substitution. However, we have previously shown that perceptual grouping between the target and flankers, rather than low-level mechanisms, determines crowding. There are many grouping cues that can determine crowding, such as low- and high-level feature similarity, low- and high-level pattern regularity, and good Gestalt. Here we show that pattern completion, another grouping cue that is important for crowding in foveal vision, is also important in peripheral vision. We also describe computer simulations that show how pattern completion, and crowding in general, can be partly explained by recurrent processing.
Success prioritized distributed coordination function (2016)

In this letter, we present a random access protocol with success priority, success prioritized distributed coordination function (SP-DCF), based on IEEE 802.11 DCF. Success stations (STAs) are prioritized contentionlessly to transmit the next data frame in the transmit queue in a random manner. We develop a performance analysis model of SP-DCF which enables us to estimate a variety of performance indexes such as the throughput or the frame discard rate (FDR) in a high accuracy for saturated wireless networks. The numerical analysis and simulation results show that the proposed SP-DCF achieves higher throughput and lower FDR as compared with the conventional DCF especially for heavily-congested wireless networks.
Vector backscattered signal analysis of piggyback modulation for passive UHF RFID Tags (2011)

We describe a “piggyback modulation” technique to integrate sensing functions with existing standard passive UHF RFID tags through electromagnetic coupling. Instead of focusing on the scalar backscattered power that is proportional to the radar cross section (RCS), we present vector analysis and measurement for backscattered signals with piggyback modulation. Measuring both amplitude and phase of the backscattered wave makes advanced demodulations possible. Quasi-4-QAM demodulation is proposed to reduce the interferences between two independent data streams and improve the bit error rate. The measurement setup, experimental results, and demodulation analysis for the conventional ASK and quasi-4-QAM are presented.
Initial clinical experience with BRAF<sup>V600E</sup> mutation analysis of core‐needle biopsy specimens from thyroid nodules (2015)

The greater diagnostic performance of CNB + BRAF(V600E) and its lower rate of inconclusive results than FNA + BRAF(V600E) suggest that CNB + BRAF(V600E) can reduce rates of preventable diagnostic surgery.
Reducing DRAM footprint with NVM in Facebook (2018)

Popular SSD-based key-value stores consume a large amount of DRAM in order to provide high-performance database operations. However, DRAM can be expensive for data center providers, especially given recent global supply shortages that have resulted in increasing DRAM costs. In this work, we design a key-value store, MyNVM, which leverages an NVM block device to reduce DRAM usage, and to reduce the total cost of ownership, while providing comparable latency and queries-per-second (QPS) as MyRocks on a server with a much larger amount of DRAM. Replacing DRAM with NVM introduces several challenges. In particular, NVM has limited read bandwidth, and it wears out quickly under a high write bandwidth.
From azido acids to macrolactams and macrolactones (1988)

A new method is reported for the conversion of azido acids into lactams, via thioester formation and in situ azide reduction and cyclisation under high-dilution conditions; since the quantitative conversion of macrolactams to macrolactones has been shown to be feasible, this results in an indirect, alternative macrolactonisation procedure.
Erythropoietin Induces Tyrosine Phosphorylation of Jak2, STAT5A, and STAT5B in Primary Cultured Human Erythroid Precursors (1998)

We examined signaling by erythropoietin in highly purified human colony forming unit-erythroid cells, generated in vitro from CD34(+) cells. We found that erythropoietin induces tyrosine phosphorylation of Jak2, STAT5A, and STAT5B. Tyrosine phosphorylation of Jak2 reaches a peak around 10 minutes after stimulation and is maximum at 5 U/mL of erythropoietin. Tyrosine phosphorylation of STAT5 is accompanied by the translocation of activated STAT5 to the nucleus as shown by electrophoretic mobility shift assay (EMSA) using 32Pi-labeled STAT5 binding site in the beta-casein promoter. Tyrosine phosphorylation STAT1 or STAT3 was not detected in human erythroid precursors after stimulation with erythropoietin. Crkl, an SH2/SH3 adapter protein, becomes coimmunoprecipitated specifically with STAT5 from erythropoietin-stimulated erythroid cells; although it was shown to become associated with c-Cbl in the studies using cell lines. Thus, human erythroid precursors can be expanded in vitro in sufficient numbers and purity to allow its usage in signal transduction studies. This report sets a basis for further studies on signaling in primary cultured human erythroid precursors, which in turn contribute to our better understanding in the differentiation processes of erythrocytes and their precursors.
Magneto-optical visualizer of magnetic field topology (1992)

Bismuth substituted rare-earth ferrite-garnet films (Bi-REFG) grown by means of liquid phase epitaxy technique (LPE) on gallium-gadolinium garnet (GGGl substrate with (111) orientation were used as magneto-optical (MO) visualizers. The films had the following features: Chemical formula (BiLuPr) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> (FeGa) <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">12</sub> thickness, pro /spm mu/m 2 saturation field in (1111 plane, Oe 5 coercivity in (111) plane, Oe 0.5 The magneto-optical head is shown on Fig. 1. MO film by the substrate side was glued by immersion liquid to the widest plane of the glass prism. The prism was a film holder and radiation input, simultaneously. Linearly polarized laser beam was focused through the prism and substrate on the MO layer in the contact place of the latter with current structure. Further, laser beam was undergone total inner reflection on the interface MO film - current structure, was reconstructed by objective and fallen on the photoreceiver. The optical system as a whole was designed like a laser scanning polarimeter.
Studies on fouling by the freshwater mussel<i>limnoperna fortunei</i>and the antifouling effects of low energy surfaces (1999)

Attachment of the freshwater mussel, Limnoperna fortunei, was tested using non‐treated surfaces, viz. glass, nylon, rubber, silicone and Teflon, together with glass surfaces modified with nine kinds of silane coupling agents. Among the surfaces tested, the mussel avoided attaching to Teflon, silicone, and glass modified with 3‐bromopropyltrimethoxysilane or 3,3,3‐(trifluo‐ropropyl)‐trimethoxysilane. With respect to the relationship between the percentage attachment and the surface free energy (sfe) of the substrates, it was found that attachment was considerably reduced on the substrates which exhibited relatively low sfe, as above. The mean number of secreted byssuses per attaching mussel also decreased with decreasing substrate sfe. Furthermore, when the sfe was divided into the dispersion and polar components, the percentage mussel attachment was related to the polar component. These results suggest that effective antifouling towards L. fortunei is achieved on substrates with a low sfe polar component.