gebhart/patrepeval huggingface dataset:
A Key Role for the <i>Arabidopsis</i> WIN3 Protein in Disease Resistance Triggered by <i>Pseudomonas syringae</i> That Secrete AvrRpt2 (2007)

Effector proteins injected by the pathogenic bacteria Pseudomonas syringae into plants can have profound effects on the pathogen-host interaction due to their efficient recognition by plants and the subsequent triggering of defenses. The AvrRpt2 effector triggers strong local and systemic defense (called systemic acquired resistance [SAR]) responses in Arabidopsis thaliana plants that harbor a functional RPS2 gene that encodes an R protein in the coiled-coil, nucleotide-binding domain, leucine-rich repeat class. The newly identified win3-T mutant shows greatly reduced resistance to P syringae carrying avrRpt2. In win3-T plants, RIN4 cleavage, an early AvrRpt2-induced event, is normal. However, salicylic acid accumulation is compromised, as is SAR induction and the local hypersensitive cell death response after infection by P syringae carrying avrRpt2. WIN3 encodes a member of the firefly luciferase protein superfamily. Expression of WIN3 at an infection site partially requires PAD4, a protein known to play a quantitative role in RPS2-mediated signaling. WIN3 expression in tissue distal to an infection site requires multiple salicylic acid regulatory genes. Finally, win3-T plants show modestly increased susceptibility to virulent P syringae and modestly reduced SAR in response to P. syringae carrying avrRpm1. Thus, WIN3 is a key element of the RPS2 defense response pathway and a basal and systemic defense component.
Detecting carotid stenosis from skin vibrations using Laser Doppler Vibrometry – An in vitro proof-of-concept (2019)

Early detection of asymptomatic carotid stenosis may help identifying individuals at risk of stroke. We explore a new method based on laser Doppler vibrometry (LDV) which could allow the non-contact detection of stenosis from neck skin vibrations due to stenosis-induced flow disturbances. Experimental fluid dynamical tests were performed with water on a severely stenosed patient-specific carotid bifurcation model. Measurements were taken under various physiological flow regimes both in a compliant and stiff-walled version of the model, at 1 to 4 diameters downstream from the stenosis. An inter-arterial pressure catheter was positioned as reference. Increasing flow led to corresponding increase in power spectral density (PSD) of pressure and LDV recordings in the 0-500 Hz range. The stiff model lead to higher PSD. PSD of the LDV signal was less dependent on the downstream measurement location than pressure. The strength of the association between PSD and flow level, model material and measuring location was highest in the 0-50 Hz range, however useful information was found up to 200 Hz. This proof-of-concept suggests that LDV has the potential to detect stenosis-induced disturbed flow. Further computational and clinical validation studies are ongoing to assess the sensitivity and specificity of the technique for clinical screening.
Optical Properties of Carbon Compounds Near the K-edge (2007)

XANES region optical properties of the following four carbon compounds with π* molecular orbitals are investigated: C60, C70, a carbon nanotube, and graphite. To determine the real and imaginary parts of the optical constants of the above, the atomic-scattering factors of these compounds near the K-edge of carbon are calculated using observed XANES spectra data and the Hartree-Slater method. Anomalous dispersions are observed in the real and imaginary parts of the optical constants near the K-edge. Each of the compounds are found to possess refractive indices that vary sharply with photon energy. In fact, we provide optical data for these four compounds that has not previously been given anywhere else.
Normalized Transillumination of Fluorescent Proteins in Small Animals (2006)

We investigated the capacity of normalized transillumination methods in imaging fluorescent proteins in visible light, in phantoms and in live mice. We demonstrate significant imaging improvements over epi-illumination imaging, as commonly applied today. Of particular importance is the significant betterment in contrast achieved, due to minimization of the influence of autofluorescence and the enhancement of depth sensitivity compared to epi-illumination imaging. Although normalized transillumination does not match the accuracy and quantification capacity of tomographic imaging, it nevertheless attains key advantages over other planar optical imaging methods while preserving implementation simplicity. Due to the balance achieved between simplicity and accuracy, normalized transillumination approaches could serve as an important alternative molecular imaging method.
Perfusion-weighted Magnetic Resonance Imaging in Adult Moyamoya Syndrome: Characteristic Patterns and Change after Surgical Intervention: Case Report (2002)

PWI demonstrates characteristic patterns of cerebral perfusion in patients with moyamoya disease and documents improved perfusion after successful surgical intervention. Quantitative analysis of the difference of time-to-peak measurements between the anterior and posterior circulation may be a marker of the severity of the disease.
A Comparative Study Between an Oil-in-Water Emulsion and Nonlipid Eye Drops Used for Rewetting Contact Lenses (2015)

The use of SYSTANE BALANCE Lubricant Eye Drops as a rewetting drop in a group of wearers who experienced symptoms of CLD improved subjective comfort scores, increased comfortable wearing time, and reduced signs of LWE and corneal staining, when compared with the use of non-lipid-containing contact lens rewetting eye drops.
Laboratory and Field Studies of Poly(2,5-bis(N-methyl-N-hexylamino)phenylene vinylene) (BAM-PPV): A Potential Wash Primer Replacement for Army Military Vehicles (2014)

In this study, an electroactive polymer (EAP), poly(2,5-bis(N-methyl-N- hexylamino)phenylene vinylene) (BAM-PPV), was tested as an alternative to current hexavalent chromium (Cr(VI))-based Army wash primers. BAM-PPV was tested in both laboratory and field studies to determine its adhesive and corrosion-inhibiting properties when applied to steel and aluminum alloys. The Army Research Laboratory (ARL) tests showed that BAM-PPV combined with an epoxy primer and the Army chemical agent-resistant coating (CARC) topcoat met Army performance requirements for military coatings. After successful laboratory testing, the BAM-PPV was then field tested for one year at the Aberdeen Test Center (ATC). This field testing showed that BAM-PPV incorporated into the Army military coating survived with no delamination of the coating and only minor corrosion on the chip sites.
Effect of Epilobium angustifolium L. extracts and polyphenols on cell proliferation and neutral endopeptidase activity in selected cell lines. (2006)

The ability of Epilobium extracts and polyphenols to induce neutral endopeptidase (NEP) activity and to inhibit the proliferation in cell lines with high NEP expression (SK-N-SH) and with low NEP expression (PC-3) was investigated. Epilobium extracts enhanced in a dose-depend manner NEP activity in both cell lines with additional inhibition of cell proliferation. The sensitivity of cells depended on basal enzyme activity. SK-N-SK cells were much more sensitive than PC-3 cells. Oenothein B enhanced NEP activity at a concentration of 5-40 microM while quercetin-3-glucuronide and quercetin-3-O-(6"-gal-loyl) galactoside showed slight or no activity at a concentration of 100 microM. The comparison of activities of the extracts with oenothein B, a dimeric macrocyclic ellagitannin, suggests that the latter is mostly responsible for the observed effects. Taking into account the role of NEP in the homeostasis of signalling peptides, Epilobium angustifolium extracts may be a potential herbal remedy in diseases connected with the disturbed metabolism of signaling peptides caused by an unbalanced neutral endopeptidase activity.
Electron cross-field transport in a miniaturized cylindrical Hall thruster (2006)

Conventional annular Hall thrusters become inefficient when scaled to low power. Cylindrical Hall thrusters, which have lower surface-to-volume ratio, are more promising for scaling down. They presently exhibit performance comparable with conventional annular Hall thrusters. The present paper gives a review of the experimental and numerical investigations of electron cross-field transport in the 2.6-cm miniaturized cylindrical Hall thruster (100-W power level). We show that, in order to explain the discharge current observed for the typical operating conditions, the electron anomalous collision frequency /spl nu//sub B/ has to be on the order of the Bohm value, /spl nu//sub B/ /spl ap/ /spl omega//sub c//16. The contribution of electron-wall collisions to cross-field transport is found to be insignificant. The optimal regimes of thruster operation at low background pressure (below 10/sup -5/ torr) in the vacuum tank appear to be different from those at higher pressure (/spl sim/10/sup -4/ torr).
Using Intracluster Light to Study Cluster Evolution (2004)

We present some early results from our deep imaging survey of galaxy clusters intended to detect and study intracluster light (ICL). From our observations to date, we find that ICL is common in galaxy clusters, and that substructure in the ICL also appears to be common as well. We also discuss some initial comparisons of our imaging results to high-resolution numerical simulations of galaxy clusters, and give avenues for future research.
ChemInform Abstract: N‐BROMODIFLUOROMETHANIMINE (1984)

Abstract Aus dem erst seit kurzem zur Verfügung stehenden Fluorcyan (I) gelingt durch Oxidation mit Brom in Gegenwart von KF die Herstellung der Titelverbindung (II), einem blaßgelben Gas.
SuperForms: a security-enhanced smart electronic form management system (2002)

The initial design of SuperForms, an automated system for designing, filling out, routing, and tracking business forms, is described. SuperForms is shown to be able to: create high-quality screen images for blank forms from paper copies by scanning and image processing; fill out forms quickly and accurately using an interactive user interface that includes error checking, help menus, user profiles, and automated calculations; use public-key cryptography to append multiple digital signatures to forms; route and track forms through a network; add annotations; and to receive automatic reminders when action on forms is due. The security-enhanced features include user authentication and encryption for privacy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
New Impact Factor Reflects Journal's Growth (2009)

Thomson Scientific’s 2008 journal impact factor numbers were published last summer, and Neuro-Oncology’s predominance in the field remains undisputed. Neuro-Oncology’s impact factor number now stands at 5.000. Neuro-Oncology remains in the top 25% of oncology journals (where it is ranked 25th of 141 journals) and clinical neurology titles (where it is 15th of 156 journals).

The impact factor is determined in part by the journal’s total number of articles published in 2007, which represented a nearly 60% increase from the previous year (46 in 2007 versus 29 in 2006). Because of the increase in our publication frequency from quarterly to bimonthly in 2008 and from bimonthly to monthly in 2010, the trend in rising numbers of published papers will continue into the foreseeable future. Our aim is to see increases in our impact factor but, more important, growth in our impact on the neuro-oncology community and, through it, service to patients with brain tumors.

For our growth, we are indebted to our editorial board, whose members are listed in every issue of the journal, and to our peer reviewers, all of whom have helped us reach and maintain our enviable position.

Listed below are those peer reviewers who are not on our editorial board but have committed many volunteer hours over the past year to critiquing manuscripts submitted to the journal and guiding us in our choices of which to publish. This vibrant community of scientists and physicians helps the journal—and the field—prosper. Please join us in thanking them for their service and expertise.

Peer Reviewers

Lauren E. Abrey

Joachim M. Baehring

Rolf F. Barth

Tracy T. Batchelor

Michael E. Berens

Jaclyn A. Biegel

Wolfgang Bohn

Paul D. Brown

Carmine M. Carapella

Maria G. Castro

Eric L. Chang

Shiyuan Cheng

Olivier Chinot

Kenneth J. Cohen

Howard Colman

Joseph Costello

Faith G. Davis

Lisa M. DeAngelis

Adam P. Dicker

Graziella Filippini

Peter A. Forsyth

Takamitsu Fujimaki

Caterina Giannini

Francesc Graus

Nalin Gupta

Chunhai (Charlie) Hao

John W. Henson

Fred H. Hochberg

Graeme Hodgson

Isa M. Hussaini

Koichi Ichimura

Yasuo Iwadate

Edward Jackson

Andreas H. Jacobs

Robert B. Jenkins

Randy Jensen

Annette Johnson

Takashi Komori

Jay S. Loeffler

Joseph C. Loftus

Ian E. McCutcheon

Tracy Richmond McKnight

Alex McMillan

Louis Burt Nabors

Mitsutoshi Nakada

Hideho Okada

Marios Papadopoulos

John Park

Andrew T. Parsa

Vinay K. Puduvalli

Jeffrey J. Raizer

Lisa R. Rogers

Tena Rosser

Robert Rostomily

James Rubenstein

Jann N. Sarkaria

David Schiff

Hiroki Shirato

Riccardo Soffietti

Yukihiko Sonoda

Shingo Takano

Martin J. B. Taphoorn

Christopher D. Turner

Jeffrey S. Wefel

Patrick Y. Wen

Wolfgang Wick

John K. Wiencke

Shiao Y. Woo

Ryuya Yamanaka

Ping Yang

Seiichi Yoshida

Xiang Zhang
Supplementary Figure 2 from Bioactivity and Prognostic Significance of Growth Differentiation Factor GDF15 Secreted by Bone Marrow Mesenchymal Stem Cells in Multiple Myeloma (2023)

&lt;p&gt;PDF file - 64K, Baseline phosphorylation of pT308 Akt in MOLP-6 and MM1.S cells&lt;/p&gt;
Steel bar corrosion monitoring with long-period fiber grating sensors coated with nano iron/silica particles and polyurethane (2014)

In this article, a recently proposed long-period fiber grating sensor coated with a thin layer of polyurethane and nano iron/silica particles is further developed and applied to monitor the corrosion process of deformed steel bars. Once calibrated, one coated long-period fiber grating sensor and one uncoated long-period fiber grating sensor for environmental compensation were attached to each of three steel bar samples that were tested in 3.5 wt% NaCl solution for 512 h. The resonant wavelength in long-period fiber grating spectra increased exponentially with immersion time due to corrosion of iron particles and thus reduction in coating thickness. The mass loss rate of steel bar #1 at the completion of corrosion tests (512 h of corrosion time) was correlated with that of sparse iron particles on long-period fiber grating sensor #1 after 130.5 h of immersion. The corrosion rates of long-period fiber grating sensors #2 and #3 were evaluated at 130.5 h and then used as a prediction of the corrosion rates of steel bars #2 and #3. The predicted corrosion rates by the long-period fiber grating sensors #2 and #3 were finally compared with those by potentiodynamic tests. The maximum mass loss prediction error by the long-period fiber grating sensors #2 and #3 is 26%. The coefficients of variation of three corrosion rate measurements are 0.049 by the long-period fiber grating sensors and 0.115 by the potentiodynamic tests, indicating more consistent and reliable measurements with the proposed technology.
Manufacturability analysis system: issues and future trends (2008)

Traditionally, design and manufacturing activities have taken place sequentially rather than simultaneously leading to inefficient and time consuming iterations between design and manufacturing stages. In order to expedite these iterations, manufacturability analysis systems (MASs) have been developed to allow the evaluation of various manufacturability aspects during the design stage and consequently to reduce the costs and time to market of the designed products. The definition, concepts, advantages of the MAS and its current state of development and applicability in the industrial environment are discussed in the introduction of the paper. Then, key issues and technologies related to the construction of a MAS such as methodologies applied in data input mechanisms, techniques for manufacturability reasoning and formats of the outputs generated by MASs are analysed. Furthermore, applicability of a MAS to various manufacturing processes and aspects such as manufacturability and fixturability indices that can be analysed and produced through a MAS are also commented. Disadvantages and limitations emerged from utilisation of MASs are critically analysed and presented. Finally, the paper concludes with discussion and suggestions for some prospective research trends and challenges in building and exploiting MASs. Particular attention is paid to the application of a MAS to micro-manufacturing processes on which, nowadays, both academics and industry are focusing their attentions for identifying future research and technological challenges and opportunities.
<i>In situ</i> x-ray photoelectron spectroscopy and capacitance voltage characterization of plasma treatments for Al2O3/AlGaN/GaN stacks (2014)

We investigate the Al2O3/AlGaN/GaN metal-oxide-semiconductor structure pretreated by O2 anneals, N2 remote plasma, and forming gas remote plasma prior to atomic layer deposition of Al2O3 using in situ X-ray photoelectron spectroscopy, low energy electron diffraction, and capacitance- voltage measurements. Plasma pretreatments reduce the Ga-oxide/oxynitride formation and the interface state density, while inducing a threshold voltage instability.
Rho-Associated Kinase Inhibitor Eye Drop (Ripasudil) Transiently Alters the Morphology of Corneal Endothelial Cells (2015)

Ripasudil induces transient guttae-like findings in humans, most likely due to protrusion formation along intracellular borders caused by the reduction in actomyosin contractility of the corneal endothelial cells. No severe adverse effects were observed. Physicians should be aware that ROCK inhibitors can cause these guttae-like findings, to avoid misdiagnosing patients as having Fuchs endothelial corneal dystrophy. (www.umin.ac.jp/ctr number, UMIN000018340.).
Tangeretin inhibits extracellular‐signal‐regulated kinase (ERK) phosphorylation (2005)

Tangeretin is a methoxyflavone from citrus fruits, which inhibits growth of human mammary cancer cells and cytolysis by natural killer cells. Attempting to unravel the flavonoid's action mechanism, we found that it inhibited extracellular-signal-regulated kinases 1/2 (ERK1/2) phosphorylation in a dose- and time-dependent way. In human T47D mammary cancer cells this inhibition was optimally observed after priming with estradiol. The spectrum of the intracellular signalling kinase inhibition was narrow and comparison of structural congeners showed that inhibition of ERK phosphorylation was not unique for tangeretin. Our data add tangeretin to the list of small kinase inhibitors with a restricted intracellular inhibition profile.
Chromosomal Substitution-Dependent Differences in Cardiovascular Responses to Sodium Pentobarbital (2006)

In this study we addressed initial laboratory observations of enhanced cardiovascular sensitivity to sodium pentobarbital (PTB) in normotensive Dahl Salt Sensitive rats (SS) compared to Brown Norway (BN) rats. We also used unique consomic (chromosomal substitution) strains to confirm preliminary observations that such differences were related to chromosome 13. Increasing concentrations of PTB were administered sequentially to SS, BN, and SS strains with BN chromosomal substitutions until the point of cardiovascular collapse. Both spontaneous and controlled ventilation were studied. The effect of large (450 microg/mL) and small (35 microg/mL) concentrations of PTB on in situ transmembrane potential of mesenteric arterial vascular smooth muscle (VSM) cells was also measured in these animals with local sympathetic innervation both intact and eliminated. An analysis of variance was used to identify significant differences among groups. Despite virtually identical plasma clearance of PTB, cardiovascular collapse occurred at approximately 35%-45% smaller cumulative doses of administered PTB in SS and other strains compared with BN and SS.13BN (introgression of BN chromosome 13 into an SS) in both spontaneous and controlled ventilation. In neurally intact preparations, large dose PTB-induced VSM hyperpolarization was 4-5 times greater than the small dose in SS and SS.16BN but not in BN and SS.13BN strains. Denervation eliminated this strain difference. These results suggest that enhanced cardiovascular sensitivity to PTB in SS rats is related to greater hyperpolarization of VSM transmembrane potential in resistance vessels and this effect is associated with chromosome 13.
Role of CaMKIIδ phosphorylation of the cardiac ryanodine receptor in the force frequency relationship and heart failure (2010)

The force frequency relationship (FFR), first described by Bowditch 139 years ago as the observation that myocardial contractility increases proportionally with increasing heart rate, is an important mediator of enhanced cardiac output during exercise. Individuals with heart failure have defective positive FFR that impairs their cardiac function in response to stress, and the degree of positive FFR deficiency correlates with heart failure progression. We have identified a mechanism for FFR involving heart rate dependent phosphorylation of the major cardiac sarcoplasmic reticulum calcium release channel/ryanodine receptor (RyR2), at Ser2814, by calcium/calmodulin-dependent serine/threonine kinase-delta (CaMKIIdelta). Mice engineered with an RyR2-S2814A mutation have RyR2 channels that cannot be phosphorylated by CaMKIIdelta, and exhibit a blunted positive FFR. Ex vivo hearts from RyR2-S2814A mice also have blunted positive FFR, and cardiomyocytes isolated from the RyR2-S2814A mice exhibit impaired rate-dependent enhancement of cytosolic calcium levels and fractional shortening. The cardiac RyR2 macromolecular complexes isolated from murine and human failing hearts have reduced CaMKIIdelta levels. These data indicate that CaMKIIdelta phosphorylation of RyR2 plays an important role in mediating positive FFR in the heart, and that defective regulation of RyR2 by CaMKIIdelta-mediated phosphorylation is associated with the loss of positive FFR in failing hearts.
Electrical hysteresis in p-GaN metal–oxide–semiconductor capacitor with atomic-layer-deposited Al<sub>2</sub>O<sub>3</sub> as gate dielectric (2016)

Abstract The electrical hysteresis in current–voltage ( I – V ) and capacitance–voltage characteristics was observed in an atomic-layer-deposited Al 2 O 3 /p-GaN metal–oxide–semiconductor capacitor (PMOSCAP). The absolute minimum leakage currents of the PMOSCAP for forward and backward I – V scans occurred not at 0 V but at −4.4 and +4.4 V, respectively. A negative flat-band voltage shift of 5.5 V was acquired with a capacitance step from +4.4 to +6.1 V during the forward scan. Mg surface accumulation on p-GaN was demonstrated to induce an Mg–Ga–Al–O oxidized layer with a trap density on the order of 10 13 cm −2 . The electrical hysteresis is attributed to the hole trapping and detrapping process in the traps of the Mg–Ga–Al–O layer via the Poole–Frenkel mechanism.