gebhart/patrepeval huggingface dataset:
Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids (2012)

Exogenous cannabinoids, such as delta9-tetrahydrocannabinol (THC), as well as the modulation of endogenous cannabinoids, affect cognitive function through the activation of cannabinoid receptors. Indeed, these compounds modulate a number of signalling pathways critically implicated in the deleterious effect of cannabinoids on learning and memory. Thus, the involvement of the mammalian target of rapamycin pathway and extracellular signal-regulated kinases, together with their consequent regulation of cellular processes such as protein translation, play a critical role in the amnesic-like effects of cannabinoids. In this study, we summarize the cellular and molecular mechanisms reported in the modulation of cognitive function by the endocannabinoid system.
High efficiency MMIC frequency triplers for millimeter and submillimeter wavelengths (2002)

A complete wideband tripler circuit with optimized input, idler and output matching has been integrated onto GaAs. The circuit consists of a matched pair of antiparallel varactor diodes with provision for DC bias. The input impedance is near 50 /spl Omega/ in microstrip, while the output couples directly to reduced height waveguide. Circuits have been fabricated and tested for frequencies near 300 GHz. These triplers achieve a peak efficiency of 11% with a power output of 5-7 mW. While peak efficiency occurs over a narrow band, the efficiency exceeds 1% over a band of 230-325 GHz.
Knee Abduction Angle Increases With Maturation In Female Compared To Male Athletes (2009)

Onset of anterior cruciate ligament (ACL) injury risk factors in females may coincide with rapid adolescent growth. PURPOSE: To identify if females develop divergent peak knee abduction angle (KAb) relative to males throughout adolescent growth. We hypothesized that females would have increased KAb, compared to males, following the onset of adolescent maturation. METHODS: A total of 1461 subject visits were collected using a 3D motion analysis system. KAb was identified during the landing phase from three box drop vertical jump (DVJ) trials. Percent of adult stature (PAS) was estimated using the Khamis-Roche method. Subjects were grouped into ten maturational groups from 81 to 100 PAS. A two-way ANOVA was used with sex and PAS as the independent variables and non-dominant knee abduction as the dependent variable. An average of 113.8 females and 32.3 males were in each group. RESULTS: A significant sex by PAS interaction (P < 0.001) was found in KAb (Figure 1). An increase in maturity resulted in greater KAb in females while males showed no change. Post-hoc analyses showed consistent sex differences in groups greater than 88% of adult stature. CONCLUSIONS: Sex differences in KAb during and following rapid adolescent growth may contribute to the increased risk of ACL injury in that develops in post-pubertal females. Peak height velocity occurs at approximately 91.3 percent of adult stature. Therefore, the sex differences in this ACL injury risk factor appear to coincide with the adolescent growth spurt. These data suggest that interventional strategies focused on preventing "high risk" landing biomechanics should be implemented in children prior to or during their growth spurt.
Combining EEG and Eye Tracking: Using Fixation-Locked Potentials in Visual Search (2013)

Visual search is a complex task that involves many neural pathways to identify relevant areas of interest within a scene. Humans remain a critical component in visual search tasks, as they can effectively perceive anomalies within complex scenes. However, this task can be challenging, particularly under time pressure. In order to improve visual search training and performance, an objective, process-based measure is needed. Eye tracking technology can be used to drive real-time parsing of EEG recordings, providing an indication of the analysis process. In the current study, eye fixations were used to generate ERPs during a visual search task. Clear differences were observed following performance, suggesting that neurophysiological signatures could be developed to prevent errors in visual search tasks.
Classifying and Comparing Approaches to Subspace Clustering with Missing Data (2019)

In recent years, many methods have been proposed for the task of subspace clustering with missing data (SCMD), and its complementary problem, high-rank matrix completion (HRMC). Given incomplete data drawn from a union of subspaces, these methods aim to simultaneously cluster each data point and recover the unobserved entries. In this work, we review the current state of this literature. We organize the existing methods into five distinct families and discuss their relative strengths and weaknesses. This classification exposes some gaps in the current literature, which we fill by introducing a few natural extensions of prior methods. Finally, we provide a thorough and unbiased evaluation of representative methods on synthetic data. Our experiments demonstrate a clear advantage for alternating between projected zero-filled sparse subspace clustering, and per-group matrix completion. Understanding why this intuitive but heuristic method performs well is an open problem for future theoretical study.
Synthesis and Biosynthetic Trafficking of Membrane Lipids (2011)

Eukaryotic cells can synthesize thousands of different lipid molecules that are incorporated into their membranes. This involves the activity of hundreds of enzymes with the task of creating lipid diversity. In addition, there are several, typically redundant, mechanisms to transport lipids from their site of synthesis to other cellular membranes. Biosynthetic lipid transport helps to ensure that each cellular compartment will have its characteristic lipid composition that supports the functions of the associated proteins. In this article, we provide an overview of the biosynthesis of the major lipid constituents of cell membranes, that is, glycerophospholipids, sphingolipids, and sterols, and discuss the mechanisms by which these newly synthesized lipids are delivered to their target membranes.
Larynx preservation in surgical treatment of cervical esophageal cancer - combined procedure of laryngeal suspension and cricopharyngeal myotomy (2008)

a larynx-preserving procedure was performed on 10 out of 22 (45%) patients in the surgical treatment of hypopharyngeal and cervical esophageal cancer. At rst, all 10 patients were treated with concurrent radiochemotherapy with cisplatin (10 mg/m 2 /day), 5-uorouracil (500 mg/m 2 /day) and radiation (2 Gy/day) ve times per week for 4 weeks. After preoperative radiochemotherapy, the larynx-preserving procedure, combining laryngeal suspension and cricopharyngeal myotomy, was performed. The operative and hospital mortality rate was 0%. The incidence of post-operative morbidity with minor complications was 70% in the present study. Laryngeal speech and oral food intake were preserved in all patients after this procedure. The new larynx-preserving procedure combining laryngeal suspension and cricopharyngeal myotomy for cervical esophageal cancer is a favorable operative method for retaining intelligible laryngeal speech and good food intake.
An effective and efficient ATPG-based combinational equivalence checker (2005)

An effective and efficient ATPG-based combinational equivalence checker.
Effect of Wavelength Range on the Measurement Accuracy of Some Selected Soil Constituents Using Visual-Near Infrared Spectroscopy (2006)

The wavelength range is one of the main components affecting the measurement accuracy with visible (vis) and near infrared (NIR) spectroscopy. The performance of two commercially-available spectrophotometers with different wavelength ranges for measurement of selected soil attributes was evaluated. The two spectrophotometers considered were a diode array with a short wavelength range (SWR) of 300–1700 nm and a combination of diode array and scanning monochromator with a full wavelength range (FWR) of 350–2500 nm. Scanning was performed on wet-fresh ( in situ conditions) and dry-processed (laboratory conditions) soil samples, to estimate the effect of moisture content on the performance of the two spectrophotometers. Partial least squares (PLS) regression with the leave-one-out cross validation technique was used to develop calibration models relating soil spectra with chemical attributes. Results showed that under wet field soil conditions pH, available phosphorus (P), cation exchange capacity (CEC), potassium (K) and calcium (Ca) were more accurately predicted with the SWR, whereas total nitrogen (N), total carbon (C), sodium (Na) and magnesium (Mg) were better predicted with the FWR. The significant effect of the water absorption at a wavelength of 1950 nm which created considerable changes in the shape of spectra and subsequently loss of important information available at wavelengths greater than 2000 nm, reduced the efficiency of the FWR instrument. The dry soil conditions led to a superior performance of the FWR instrument over the SWR instrument for measurement of all soil attributes. This suggests that a greater wavelength range than 1700 nm is not useful for improving the measurement accuracy of soil attributes (except N and C) with vis-NIR spectroscopy when measurement is to be carried out in the field under wet conditions.
Nucleotide sequence of a nuc gene encoding the thermonuclease of<i>Staphylococcus intermedius</i> (1992)

International audience
Polyimide Asymmetric Membranes for Hydrogen Separation: Influence of Formation Conditions on Gas Transport Properties (2006)

Abstract The asymmetric flat sheet membrane was developed for separation of hydrogen from its mixtures with other gases. The composition of the casting solution and conditions of membrane preparation were optimized for the pilot scale membrane production. The resulting membrane have a high hydrogen flux (1 m 3 (STP)/m 2 h*bar) and selectivity of H 2 /CH 4 at least 100, the value close to intrinsic selectivity of Matrimid 5218, material used for the asymmetric structure formation. The membrane is stable against mixtures of liquid hydrocarbons and can withstand heating up to 200 °C. The non‐woven fabric used as a support for the asymmetric membrane gives to the membrane excellent mechanical properties and allows to use the membrane in GKSS gas separation modules.
EFFECTS OF HERPES SIMPLEX VIRUS VECTOR-MEDIATED ENKEPHALIN GENE THERAPY ON BLADDER OVERACTICITY AND NOCICEPTION (2009)

You have accessJournal of Urology1 Apr 2009EFFECTS OF HERPES SIMPLEX VIRUS VECTOR-MEDIATED ENKEPHALIN GENE THERAPY ON BLADDER OVERACTICITY AND NOCICEPTION Hitoshi Yokoyama, Chikashi Saitoh, Minoru Miyazato, Osamu Nishizawa, Michael B Chancellor, William F Goins, James R Goss, Joseph C Glorioso, and Naoki Yoshimura Hitoshi YokoyamaHitoshi Yokoyama More articles by this author , Chikashi SaitohChikashi Saitoh More articles by this author , Minoru MiyazatoMinoru Miyazato More articles by this author , Osamu NishizawaOsamu Nishizawa More articles by this author , Michael B ChancellorMichael B Chancellor More articles by this author , William F GoinsWilliam F Goins More articles by this author , James R GossJames R Goss More articles by this author , Joseph C GloriosoJoseph C Glorioso More articles by this author , and Naoki YoshimuraNaoki Yoshimura More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)60069-0AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "EFFECTS OF HERPES SIMPLEX VIRUS VECTOR-MEDIATED ENKEPHALIN GENE THERAPY ON BLADDER OVERACTICITY AND NOCICEPTION." The Journal of Urology, 181(4S), p. 20 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 20 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Hitoshi Yokoyama More articles by this author Chikashi Saitoh More articles by this author Minoru Miyazato More articles by this author Osamu Nishizawa More articles by this author Michael B Chancellor More articles by this author William F Goins More articles by this author James R Goss More articles by this author Joseph C Glorioso More articles by this author Naoki Yoshimura More articles by this author Expand All Advertisement PDF downloadLoading ...
Potent anti-tumor effects of receptor-retargeted syncytial oncolytic herpes simplex virus (2021)

Most oncolytic virotherapy has thus far employed viruses deficient in genes essential for replication in normal cells but not in cancer cells. Intra-tumoral injection of such viruses has resulted in clinically significant anti-tumor effects on the lesions in the vicinity of the injection sites but not on distant visceral metastases. To overcome this limitation, we have developed a receptor-retargeted oncolytic herpes simplex virus employing a single-chain antibody for targeting tumor-associated antigens (RR-oHSV) and its modified version with additional mutations conferring syncytium formation (RRsyn-oHSV). We previously showed that RRsyn-oHSV exhibits preserved antigen specificity and an ∼20-fold higher tumoricidal potency <i>in vitro</i> relative to RR-oHSV. Here, we investigated the <i>in vivo</i> anti-tumor effects of RRsyn-oHSV using human cancer xenografts in immunodeficient mice. With only a single intra-tumoral injection of RRsyn-oHSV at very low doses, all treated tumors regressed completely. Furthermore, intra-venous administration of RRsyn-oHSV resulted in robust anti-tumor effects even against large tumors. We found that these potent anti-tumor effects of RRsyn-oHSV may be associated with the formation of long-lasting tumor cell syncytia not containing non-cancerous cells that appear to trigger death of the syncytia. These results strongly suggest that cancer patients with distant metastases could be effectively treated with our RRsyn-oHSV.
Memory Nets: Knowledge Representation for Intelligent Agent Operations in Real World (2019)

In this paper, we introduce Memory Nets, a knowledge representation targeted at Autonomous Intelligent Agents (IAs) operating in real world. The main focus is on a knowledge base (KB) that on the one hand is able to leverage the large body of openly available semantic information, and on the other hand allows to incrementally accumulate additional knowledge from situated interaction. Such a KB can only rely on operable semantics fully contained in the knowledge base itself, avoiding any type of hidden semantics in the KB attributes, such as human-interpretable identifier. In addition, it has to provide means for tightly coupling the internal representation to real-world events. We propose a KB structure and inference processes based on a knowledge graph that has a small number of link types with operational semantics only, and where the main information lies in the complex patterns and connectivity structures that can be build incrementally using these links. We describe the basic domain independent features of Memory Nets and the relation to measurements and actuator capabilities as available by autonomous entities, with the target of providing a KB framework for researching how to create IAs that continuously expand their knowledge about the world.
MYCN is retained in single copy at chromosome 2 band p23-24 during amplification in human neuroblastoma cells. (1994)

Amplification of the human N-myc protooncogene, MYCN, is frequently seen either in extrachromosomal double minutes or in homogeneously staining regions of aggressively growing neuroblastomas. MYCN maps to chromosome 2 band p23-24, but homogeneously staining regions have never been observed at this band, suggesting transposition of MYCN during amplification. We have employed fluorescence in situ hybridization to determine the status of MYCN at 2p23-24 in five human neuroblastoma cell lines. All five lines carried, in addition to amplified MYCN in homogeneously staining regions or double minutes, single-copy MYCN at the normal position. In one line there was coamplification of MYCN together with DNA of the host chromosome 12, to which MYCN had been transposed. Our results suggest a model of amplification where MYCN is retained at its original location. They further sustain the view that either the initial events of MYCN amplification or the further evolution of amplified MYCN copies follow mechanisms different from those leading to amplification of drug-resistance genes.
Supplementary material from "Quantitative assessment of cervical softening during pregnancy with shear wave elasticity imaging: an in vivo longitudinal study" (2019)

We report here the results of a longitudinal study of cervix stiffness during pregnancy. Thirty women, ages ranging from 19 to 37 years, were scanned with ultrasound at five time points beginning at their normal first-trimester screening (8–13 weeks) through term pregnancy (nominally 40 week) using a clinical ultrasound imaging system modified with a special ultrasound transducer and system software. The system estimated the shear wave speed (its square proportional to the shear modulus under idealized conditions) in the cervix. We found a constant fractional reduction (about 4% per week) in shear wave speed with increasing gestational age. We also demonstrated a spatial gradient in shear wave speed along the length of the cervix (softest at the distal end). Results were consistent with our previous <i>ex vivo</i> and <i>in vivo</i> work in women. Shear wave elasticity imaging may be a potentially useful clinical tool for objective assessment of cervical softening in pregnancy.
A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography (2020)

The complexity of glucocorticoid receptor (GR) signaling cannot be measured with direct tissue analysis in living subjects, which has stifled our understanding of GR's role in human physiology or disease and impeded the development of selective GR modulators. Herein, we report <sup>18</sup>F-5-(4-fluorobenzyl)-10-methoxy-2,2,4-trimethyl-2,5-dihydro-1H-chromeno[3,4-<i>f</i>]quinoline (<sup>18</sup>F-YJH08), a radioligand that enables noninvasive measurements of tissue autonomous GR expression levels <i>in vivo</i> with positron emission tomography (PET). YJH08 potently binds GR (<i>K</i><sub>i</sub> ∼ 0.4 nM) with ∼100-fold selectivity compared to nuclear hormone receptors in the same subfamily. <sup>18</sup>F-YJH08 was prepared <i>via</i> Cu(OTf)<sub>2</sub>(py)<sub>4</sub>-mediated radiofluorination of an arylboronic acid pinacol ester with ∼12% decay corrected radiochemical yield from the starting <sup>18</sup>F-fluoride ion. We applied treatment with the tissue-wide GR agonist dexamethasone and adrenalectomy and generated an adipocyte specific GR knockout mouse to show that <sup>18</sup>F-YJH08 specifically binds GR in normal mouse tissues, including those for which aberrant GR expression is thought to drive severe diseases (e.g., brain, adipose tissue, kidneys). Remarkably, <sup>18</sup>F-YJH08 PET also revealed that JG231, a potent and bioavailable HSP70 inhibitor, selectively degrades GR only in the adipose tissue of mice, a finding that foreshadows how GR targeted PET might be integrated into drug discovery to screen for selective GR modulation at the tissue level, beyond the historical screening that was performed at the transcriptional level. In summary, <sup>18</sup>F-YJH08 enables a quantitative assessment of GR expression levels in real time among multiple tissues simultaneously, and this technology is a first step toward unraveling the daunting complexity of GR signaling and rationally engineering tissue specific therapeutic modulators <i>in vivo.</i>
Integration of III-V Nanopillar Resonator to In-Plane Silicon Waveguides (2016)

We proposed, fabricated, and characterized new structures based on III-V compound semi-conductor nanopillars, monolithically integrated to silicon platform, for coupling spontaneous and stimulated emission to silicon waveguides.
Beyond Self-Protection (2014)

Limited work has examined how self-affirmation might lead to positive outcomes beyond the maintenance of a favorable self-image. To address this gap in the literature, we conducted two studies in two cultures to establish the benefits of self-affirmation for psychological well-being. In Study 1, South Korean participants who affirmed their values for 2 weeks showed increased eudaimonic well-being (need satisfaction, meaning, and flow) relative to control participants. In Study 2, U.S. participants performed a self-affirmation activity for 4 weeks. Extending Study 1, after 2 weeks, self-affirmation led both to increased eudaimonic well-being and hedonic well-being (affect balance). By 4 weeks, however, these effects were non-linear, and the increases in affect balance were only present for vulnerable participants-those initially low in eudaimonic well-being. In sum, the benefits of self-affirmation appear to extend beyond self-protection to include two types of well-being.
Monoamine Oxidases Regulate Telencephalic Neural Progenitors in Late Embryonic and Early Postnatal Development (2010)

Monoamine neurotransmitters play major roles in regulating a range of brain functions in adults and increasing evidence suggests roles for monoamines in brain development. Here we show that mice lacking the monoamine metabolic enzymes MAO A and MAO B (MAO AB-deficient mice) exhibit diminished proliferation of neural stem cells (NSC) in the developing telencephalon beginning in late gestation [embryonic day (E) 17.5], a deficit that persists in neonatal and adult mice. These mice showed significantly increased monoamine levels and anxiety-like behaviors as adults. Assessments of markers of intermediate progenitor cells (IPC) and mitosis showed that NSC in the subventricular zone (SVZ), but not in the ventricular zone, are reduced in MAO AB-deficient mice. A developmental time course of monoamines in frontal cortical tissues revealed increased serotonin levels as early as E14.5, and a further large increase was found between E17.5 and postnatal day 2. Administration of an inhibitor of serotonin synthesis (parachlorophenylalanine) between E14.5 and E19.5 restored the IPC numbers and SVZ thickness, suggesting the role of serotonin in the suppression of IPC proliferation. Studies of neurosphere cultures prepared from the telencephalon at different embryonic and postnatal ages showed that serotonin stimulates proliferation in wild-type, but not in MAO AB-deficient, NSC. Together, these results suggest that a MAO-dependent long-lasting alteration in the proliferation capacity of NSC occurs late in embryonic development and is mediated by serotonin. Our findings reveal novel roles for MAOs and serotonin in the regulation of IPC proliferation in the developing brain.
Triphenylamine/Tetracyanobutadiene-Based D-A-D π-Conjugated Systems as Molecular Donors for Organic Solar Cells (2011)

Thiophene-based D-A-D π-conjugated systems containing triphenylamine end groups connected to a 1,1,4,4-tetracyanobuta-1,3-diene acceptor by oligothiophene chains of variable length have been synthesized. These compounds show interesting light-harvesting properties and low-lying HOMO levels. Preliminary results on bilayer heterojunction solar cells with C(60) as acceptor show power conversion efficiency higher than 1.0%.