gebhart/patrepeval huggingface dataset:
Computer Analysis of Heart Motion from Two-Dimensional Echocardiograms (1987)

In two-dimensional echocardiography the study of the motion of the heart, especially of the left ventricle, is of central interest. Although the clinician can see this motion on real-time two-dimensional echocardiograms, its quantification can still be greatly improved. This paper presents and tests a computer method to quantify the motion of the heart from digitized image sequences. This method computes on every point of an image the two-dimensional velocity vector which characterizes its motion from this image to the next. This approach has the following advantages: 1) border recognition algorithms are no longer needed, 2) motion is not restricted to its radial component, and 3) motion information is available on every point of the image.
NetServ Framework Design and Implementation 1.0 (2011)

Eyeball ISPs today are under-utilizing an important asset: edge routers. We present NetServ, a programmable node architecture aimed at turning edge routers into distributed service hosting platforms. This allows ISPs to allocate router resources to content publishers and application service pro\-vi\-ders motivated to deploy content and services at the network edge. This model provides important benefits over currently available solutions like CDN. Content and services can be brought closer to end users by dynamically installing and removing custom modules as needed throughout the network. Unlike previous programmable router proposals which focused on customizing features of a router, NetServ focuses on deploying content and services. All our design decisions reflect this change in focus. We set three main design goals: a wide-area deployment, a multi-user execution environment, and a clear economic benefit. We built a prototype using Linux, NSIS signaling, and the Java OSGi framework. We also implemented four prototype applications: ActiveCDN provides publisher-specific content distribution and processing; KeepAlive Responder and Media Relay reduce the infrastructure needs of telephony providers; and Overload Control makes it possible to deploy more flexible algorithms to handle excessive traffic.
Multiscale, multiparadigm modeling for nano systems characterization and design (2012)

This chapter outlines our progress toward developing a first-principles-based hierarchical multiscale, multiparadigm modeling and simulation framework for the characterization and optimization of electronic and chemical properties of nanoscale materials and devices. In our approach, we build from the bottom-up by solving the quantum-mechanical (QM) Schrodinger equation for small systems. The results of these calculations lead to physical parameters that feed into methods capable of spanning longer length and time scale with minimum loss of accuracy. This is achieved by having higher-scale quantities self-consistently derived and optimized from the results at finer scales.
In contrast to other methods, we are strictly first-principles-based, and all of our parameters at all scales relate to physically measurable or QM-computable observables. Our approach that is applicable to the forward (materials phenomenology) and inverse (“materials by design”) problems. The inverse problem involves top-down predictions of structures and compositions at a lower scale from desired properties at a higher scale.
The advantages of our strategy over experimental- and phenomenological-based modeling and simulation approaches include the following: (1) providing access to details that are difficult or impossible to measure (e.g., excited electronic states in materials undergoing extreme conditions of pressure, temperature, etc.); (2) the ability to make useful predictions outside the range of experiments (i.e., since all calculations are ultimately related to first principles); and (3) providing sound, first-principles-based, steering for experiments.
Impact of Clinical Parameters on the Diagnostic Accuracy of Endorectal Coil MRI for the Detection of Prostate Cancer (2011)

The reliability of endoMRI depends on clinical parameters. Higher Gleason scores, unifocal tumors and smaller prostate volumes ameliorate endoMRI performance.
Deletion of cAMP-binding site B in the regulatory subunit of cAMP-dependent protein kinase alters the photoaffinity labeling of site A. (1988)

Photoaffinity labeling with 8-azidoadenosine 3':5'-monophosphate is a highly selective method for probing the cAMP-binding sites of the regulatory subunits of cAMP-dependent protein kinase and for identifying specific residues that are in close proximity to the cAMP-binding sites. The cAMP-binding site of a mutant RI-subunit has been characterized here and contrasted to the native RI-subunit. This mutant RI-subunit was generated by oligonucleotide-directed muta-genesis and lacks the entire second cAMP-binding domain which includes both of the residues, Trp260 and Tyr371, that are photolabeled in the native RI-subunit. The mutant RI-subunit, nevertheless, is photoaffinity-labeled with high efficiency, and the residue covalently modified was identified as Tyr244. The position of Tyr244 based on a computer graphic model of cAMP-binding site A is proposed and correlated with the presumed locations of Tyr371 and Trp260 in the native R-subunit. Photoaffinity labeling also can be used to detect functional cAMP-binding sites following electrophoretic transfer of the denatured protein to nitrocellulose. Labeling of the immobilized protein on nitrocellulose required a functional cAMP-binding site A that can be photoaffinity-labeled in solution based on the following criteria. 1) The type I R-subunit is photolabeled, whereas the type II R-subunit is not. A primary feature which distinguishes these two R-subunits is that the RI-subunit is photolabeled at both sites A and B, whereas covalent modification of the RII-subunit occurs only at site B. 2) The truncated mutant of the RI-subunit which lacks the entire second cAMP-binding domain can be photolabeled on nitrocellulose. 3) A mutant RI-subunit which can no longer be photolabeled in site B is still photolabeled on nitrocellulose. 4) A mutation which abolished cAMP binding to site A also abolished photoaffinity labeling after transfer to nitrocellulose.
A thermally stable alane–secondary amine adduct: [H<sub>3</sub>Al(2,2,6,6-tetramethylpiperidine)] (1994)

Metallation of 2,2,6,6-tetramethylpiperidine, HN[CMe2CH2]2CH2(HL), by H3AlNMe3 in diethyl ether affords a monomeric, Lewis base-stabilised amidoalane Me3NAIH2L, 1[Al–Namido, Namine 1.838(2), 2.058(2)Å], whereas treating AIH3 generated in situ with the same amine in diethyl ether yields a remarkably stable secondary amine adduct of alane H3Al(HL), 2(decomp. > 115 °C), also as a monomer in the solid [Al–NHL 2.04(1)Å].
Mapping Text with Phrase Nets (2009)

We present a new technique, the phrase net, for generating visual overviews of unstructured text. A phrase net displays a graph whose nodes are words and whose edges indicate that two words are linked by a user-specified relation. These relations may be defined either at the syntactic or lexical level; different relations often produce very different perspectives on the same text. Taken together, these perspectives often provide an illuminating visual overview of the key concepts and relations in a document or set of documents.
A novel algorithm for improved detection and discrimination of over resolved targets (2015)

A technique is proposed to achieve significantly better detection, discrimination, and automatic identification (id) for stationary or slow-moving range-Doppler over-resolved targets on or in close proximity to the ground (or sea surface). This technique is based upon a generalized inner product (GIP) approach to data analysis. This robust detector/discriminator separates radar returns from interference including ground clutter via a coherent process for separating target returns from the myriad of received signals. Through the use of coherent target templates artificial intelligence techniques will be developed to automatically id targets without human intervention.
Structural Model Estimation With Correlated Measurement Errors (1985)

Journal Article Structural model estimation with correlated measurement errors Get access MIRIAM A. REILMAN, MIRIAM A. REILMAN Department of Statisties, Southern Methodist UniversityDallas, Texas, 75275, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar RICHARD F. GUNST, RICHARD F. GUNST Department of Statisties, Southern Methodist UniversityDallas, Texas, 75275, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar MANI Y. LAKSHMINARAYANAN MANI Y. LAKSHMINARAYANAN Department of Mathematics and Statistics, University of South AlabamaMobile, Alabama 36688, U.S.A. Search for other works by this author on: Oxford Academic Google Scholar Biometrika, Volume 72, Issue 3, December 1985, Pages 669–672, https://doi.org/10.1093/biomet/72.3.669 Published: 01 December 1985 Article history Received: 01 February 1985 Revision received: 01 April 1985 Published: 01 December 1985
Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model (2003)

Previously, we showed that blueberry (BB) supplementation reversed the deleterious effects of aging on motor behavior and neuronal signaling in senescent rodents. We now report that BB-fed (from 4 months of age) APP + PS1 transgenic mice showed no deficits in Y-maze performance (at 12 months of age) with no alterations in amyloid beta burden. It appeared that the protective mechanisms are derived from BB-induced enhancement of memory-associated neuronal signaling (e.g. extracellular signal-regulated kinase) and alterations in neutral sphingomyelin-specific phospholipase C activity. Thus, our data indicate for the first time that it may be possible to overcome genetic predispositions to Alzheimer disease through diet.
Grainyhead-like transcription factors in cancer – Focus on recent developments (2020)

The role of grainyhead-like transcription factors in cancer has been widely investigated by the scientific community. However, some of its aspects do not seem to be adequately appreciated, and these are the topic of our article. In addition to their well-documented role as tumor suppressors, in many cases the grainyhead-like proteins perform tumor-promoting functions, which make them potential drug targets. However, it is difficult to directly target transcription factors, which is why we recommend an alternative approach. The transcriptional transactivation activity of grainyhead-like transcription factors is regulated by phosphorylation, and protein kinases are much more feasible drug targets. Studying the phosphorylation of grainyhead-like proteins may thus allow to identify protein kinases regulating the activity of these factors, and design inhibitors of these kinases to indirectly regulate the activity of grainyhead-like transcription factors. There are many somatic mutations in the GRHL genes that occur during cancer development. These mutations are widely distributed across the GRHL loci, and these mutations are very rare. For this reason, they are unlikely to become targets of future therapies, nevertheless some of them may be driver mutations and studying them may provide important novel information about the regulation of functioning of the GRHL genes and proteins. Analogous information may be obtained by studying single nucleotide polymorphisms in GRHL genes that are associated with disease risk. Such polymorphisms may also prove useful in identifying individuals with an increased risk of a particular disease. Impact statement In the present article, we focus on relatively little appreciated aspects of involvement of the grainyhead-like (GRHL) transcription factors in cancer. These aspects are nevertheless very important for the functioning of GRHL proteins, as well as for cancer development. Some of the GRHL factors perform tumor-promoting functions in certain types of cancer, which makes them potential drug targets. Much information is available about somatic cancer mutations in the GRHL genes, yet there are very few analyses of these mutations in the scientific literature. The activity of GRHL transcription factors is controlled by phosphorylation, and we suggest that regulating their phosphorylation with specific protein kinases provides an alternative approach to modify the activity of GRHL proteins. Some single nucleotide polymorphisms (SNPs) in the GRHL genes are associated with disease risk. Studying such SNPs may yield new information about the functioning of GRHL genes and proteins, and may also allow to identify people with an increased risk of a particular disease.
Volume regulation by human lymphocytes: Characterization of the ionic basis for regulatory volume decrease (1982)

The mechanism of volume regulation in hypotonic media was analysed in human peripheral blood mononuclear (PBM) cells. Electronic cell sizing showed that hypotonic swelling is followed by a regulatory volume decrease (RVD) phase. This was confirmed by both electron microscopy and by cellular water determinations. The rate of regulatory shrinking was proportional to the degree of hypotonicity in the 0.5-0.9 X isotonic range. Cell viability was only marginally affected in this range. The content of cellular K+ decreased during RVD, while Na+ content remained unchanged. Similarly, the efflux of 86Rb (used as a K+ analog) increased upon dilution, whereas 22Na efflux was not altered. 86Rb uptake was enhanced by hypotonic stress and both ouabain-sensitive and -insensitive components were affected. A ouabain-sensitive stimulation was also seen in Na+- free media. Ouabain partially inhibited RVD only if added to the cells hours before hypotonic challenge. A normal shrinking response was observed in K+-free media, and also in Na+-free media when Li+, choline+, or Tris+ were the substitutes. In high K+ or RB+ hypotonic media shrinking was absent and a second swelling phase was observed. Cs+ displayed an intermediate behavior, with shrinking observed at lower dilutions and secondary swelling at higher ones. The direction and magnitude of the response also changed when the external K+ concentration was varied and, with 50 mM K+, no regulatory volume change occurred following hypotonic stress. These findings suggest that RVD occurs largely by a passive loss of cellular K+, resulting from a selective increase in permeability to this ion. In addition, the (Na-K) pump appears to be activated upon cell swelling by a mechanism other than Na+ entry into the cell, but this activation is not essential for RVD.
<sup>19</sup>F electron nuclear double resonance (ENDOR) spectroscopy for distance measurements using trityl spin labels in DNA duplexes (2023)

The combination of fluorine labeling and pulsed electron-nuclear double resonance (ENDOR) is emerging as a powerful technique for obtaining structural information about proteins and nucleic acids. In this work, we explored the capability of Mims <sup>19</sup>F ENDOR experiments on reporting intermolecular distances in trityl- and <sup>19</sup>F-labeled DNA duplexes at three electron paramagnetic resonance (EPR) frequencies (34, 94, and 263 GHz). For spin labeling, we used the hydrophobic Finland trityl radical and hydrophilic OX063 trityl radical. Fluorine labels were introduced into two positions of a DNA oligonucleotide. The results indicated that hyperfine splittings visible in the ENDOR spectra are consistent with the most populated interspin distances between <sup>19</sup>F and the trityl radical predicted from molecular dynamic (MD) simulations. Moreover, for some cases, ENDOR spectral simulations based on MD results were able to reproduce the conformational distribution reflected in the experimental ENDOR line broadening. Additionally, MD simulations provided more detailed information about the melting of terminal base pairs of the oligonucleotides and about the configuration of the trityls relative to a DNA end.
Mobility management in next-generation wireless systems (1999)

This paper describes current and proposed protocols for mobility management for public land mobile network (PLMN)-based networks, mobile Internet protocol (IP) wireless asynchronous transfer mode (ATM) and satellite networks. The integration of these networks will be discussed in the context of the next evolutionary step of wireless communication networks. First, a review is provided of location management algorithms for personal communication systems (PCS) implemented over a PLMN network. The latest protocol changes for location registration and handoff are investigated for mobile IP followed by a discussion of proposed protocols for wireless ATM and satellite networks. Finally, an outline of open problems to be addressed by the next generation of wireless network service is discussed.
Activation of terminal alkynes with cis-[RuCl<sub>2</sub>(Ph<sub>2</sub>PCH<sub>2</sub>PPH<sub>2</sub>)<sub>2</sub>]: new vinylidene– and acetylide–ruthenium complexes and crystal structures of [(Ph<sub>2</sub>PCH<sub>2</sub>PPH<sub>2</sub>)<sub>2</sub>(Cl)RuCCH<sub>2</sub>]PF<sub>6</sub>and [(Ph<sub>2</sub>PCH<sub>2</sub>PPH<sub>2</sub>)<sub>2</sub>(Cl)RuCCH] complexes (1993)

The activation of alkynes HCCR with cis-[RuCl2(Ph2PCH2PPh2)2]1 leads to vinylidenes trans-[(Ph2PCH2PPh2)2(Cl)Ru+CCHR], even directly from acetylene itself (R = H) or prop-2-ynyl alcohol, from which the Ru+CCH(CH2OH) moiety is resistant to dehydration, and deprotonation with 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) directly affords trans-[(Ph2PCH2PPh2)2(Cl)Ru–CC–R] derivatives.
Organocatalytic Enantioselective Protonation of Silyl Enolates Mediated by Cinchona Alkaloids and a Latent Source of HF (2007)

Hidden benefits: The enantioselective organocatalytic protonation of silyl enolates has been achieved by using readily available cinchona alkaloid catalysts (1) and a latent source of HF that delivers “at will” the active catalytic hydrogen fluoride salt (1-HF). This approach leads to enantioselective proton transfer with high enantioselectivities of up to 92 % under mild, neutral, and metal-free conditions (see scheme, TMS=trimethylsilyl).
Supplementary Figure S3 from Rebound Effects Caused by Withdrawal of MET Kinase Inhibitor Are Quenched by a MET Therapeutic Antibody (2023)

&lt;p&gt;Interfering with receptor dimerization by mean of decoy MET severely affects receptor endocytosis&lt;/p&gt;
Enhanced Sampling and Analysis, Selection of Technology for Testing (2010)

The focus of this study includes the investigation of sampling technologies used in industry and their potential application to nuclear fuel processing. The goal is to identify innovative sampling methods using state of the art techniques that could evolve into the next generation sampling and analysis system for metallic elements. This report details the progress made in the first half of FY 2010 and includes a further consideration of the research focus and goals for this year. Our sampling options and focus for the next generation sampling method are presented along with the criteria used for choosing our path forward. We have decided to pursue the option of evaluating the feasibility of microcapillary based chips to remotely collect, transfer, track and supply microliters of sample solutions to analytical equipment in support of aqueous processes for used nuclear fuel cycles. Microchip vendors have been screened and a choice made for the development of a suitable microchip design followed by production of samples for evaluation by ANL, LANL, and INL on an independent basis.
Molecular Pathways: Revisiting Glycogen Synthase Kinase-3β as a Target for the Treatment of Cancer (2017)

Glycogen synthase kinase-3β (GSK-3β), a serine/threonine protein kinase, is a complex regulator of numerous cellular functions. GSK-3β is a unique kinase which is constitutively active in resting and nonstimulated cells. GSK-3β has been implicated in a wide range of diseases including neurodegeneration, inflammation and fibrosis, noninsulin-dependent diabetes mellitus, and cancer. It is a regulator of NF-κB-mediated survival of cancer cells, which provided a rationale for the development of GSK-3 inhibitors targeting malignant tumors. Recent studies, many of them reported over the past decade, have identified GSK-3β as a potential therapeutic target in more than 15 different types of cancer. Whereas only active GSK-3β is expressed in cancer cell nucleus, aberrant nuclear accumulation of GSK-3β has been identified as a hallmark of cancer cells in malignant tumors of different origin. This review focuses on the preclinical and clinical development of GSK-3 inhibitors and the potential therapeutic impact of targeting GSK-3β in human cancer. <i>Clin Cancer Res; 23(8); 1891-7. ©2017 AACR</i>.
Numerical modelling of transverse impact on composite coupons. (1995)

Results from low- and high-energy impact simulations of composite coupons using the LS-DYNA3D finite element code are presented. The numerically derived force and strain history data were compared with experimentale data
The JPEG XT suite of standards: status and future plans (2015)

The JPEG standard has known an enormous market adoption. Daily, billions of pictures are created, stored and exchanged in this format. The JPEG committee acknowledges this success and spends continued efforts in maintaining and expanding the standard specifications. JPEG XT is a standardization effort targeting the extension of the JPEG features by enabling support for high dynamic range imaging, lossless and near-lossless coding, and alpha channel coding, while also guaranteeing backward and forward compatibility with the JPEG legacy format. This paper gives an overview of the current status of the JPEG XT standards suite. It discusses the JPEG legacy specification, and details how higher dynamic range support is facilitated both for integer and floating-point color representations. The paper shows how JPEG XT's support for lossless and near-lossless coding of low and high dynamic range images is achieved in combination with backward compatibility to JPEG legacy. In addition, the extensible boxed-based JPEG XT file format on which all following and future extensions of JPEG will be based is introduced. This paper also details how the lossy and lossless representations of alpha channels are supported to allow coding transparency information and arbitrarily shaped images. Finally, we conclude by giving prospects on upcoming JPEG standardization initiative JPEG Privacy &amp; Security, and a number of other possible extensions in JPEG XT.
Selective dopamine DA1 stimulation with fenoldopam in cirrhotic patients with ascites: A systemic, splanchnic and renal hemodynamic study (1991)

We studied the effects of fenoldopam, a selective dopamine DA 1 agonist on systemic and splanchnic hemodynamics, renal blood flow and sodium excretion in 12 patients with alcoholic cirrhosis and ascites. Hepatic, azygos and renal veins were catheterized before and after intravenous administration of fenoldopam, 0.05 μg/kg/min for 1 hr and increased to 0.1 μg/kg/min for another hour. Mean arterial pressure progressively decreased (from 83 ± 7 to a minimum of 77 ± 8 mm Hg 100 min after starting the infusion) but returned to baseline level at 120 min. Plasma norepinephrine and renin activity increased (respectively from 567 ± 297 to 919 ± 375 pg/ml, p &lt; 0.05, and from 17 ± 14 to 23 ± 15 ng/ml/hr, p &lt; 0.05). Renal blood flow, urine output or sodium excretion did not change. Sodium output decreased at 1 hr from 6.9 μmol/min to 4.0 μmol/min, p &lt; 0.05. Both hepatic venous pressure gradient and azygos blood flow significantly increased by 21%. We conclude that the acute administration of fenoldopam did not improve renal hemodynamics or function in patients with cirrhosis and ascites. In addition, dopamine DA 1 agonism caused further increases in norepinephrine concentration and plasma renin activity. Portal pressure also increased, probably because of an increase in mesenteric blood flow. These results question the renal benefit and raise concern about the use of dopamine agonists in patients with cirrhosis and ascites. (Hepatology 1991;13:111-116).