gebhart/patrepeval huggingface dataset:
Ultraviolet amplified spontaneous emission from thin films of 4,4′-bis(9-carbazolyl)-2,2′-biphenyl and the derivatives (2004)

We demonstrate 394 nm ultraviolet amplified spontaneous emission (ASE) with a low pumping power threshold of Eth=1.3±0.2 μJ/cm2, from a thin film of an organic semiconductor 4,4′-bis(9-carbazolyl)-2,2′-biphenyl (CBP) under the pulse excitation of a N2 gas laser (337 nm). 3-methyl and 3,6-dimethyl substituted CBP derivatives also exhibited pronounced ASE in the deep-blue region of 401 and 406 nm and ASE thresholds of less than Eth=2 μJ/cm2. We also examined the ASE characteristics of N,N′-di(m-tolyl)-N,N′-diphenylbenzidine (TPD), N,N,N′,N′-tetraphenylbenzidine (DPABP) and N,N′-di(α-naphtyl)-N,N′-diphenylbenzidine (α-NPD). While TPD and DPABP showed low ASE thresholds, α-NPD did not show any ASE. We show that the large radiative decay rate (kf) of DPABP and TPD, which is derived from their short fluorescence lifetime (τf) and large quantum efficiency (ηf), leads to a low ASE threshold. On the other hand, the lack of ASE from α-NPD is ascribable to the small kf of 0.8±0.1×108 s−1, which is due to the rather long τf of 3.5 ns and small ηf of 0.29±0.02. In addition, we observed that the ASE gain is closely correlated with kf. A larger kf resulted in a larger ASE gain.
Association of neutrophil to lymphocyte ratio (NLR) with efficacy from JAVELIN Renal 101. (2020)

5061 Background: The phase 3 JAVELIN Renal 101 trial (NCT02684006) in treatment-naive patients with advanced renal cell carcinoma (aRCC) demonstrated significantly improved progression-free survival (PFS; hazard ratio [HR], 0.69; 95% CI, 0.56, 0.84; P &lt; 0.001) and higher objective response rate (ORR; 51.4% vs 25.7%) with avelumab + axitinib vs sunitinib (Motzer RJ, et al. N Engl J Med. 2019;380:1103-15). NLR has emerged as a potential prognostic biomarker in aRCC; elevated NLR is associated with poorer prognosis. Here, we describe the association of NLR with the efficacy of avelumab + axitinib from JAVELIN Renal 101. Methods: We examined baseline NLR and its association with efficacy outcomes. PFS, best overall response (per blinded independent central review using RECIST 1.1), and overall survival (OS) data from the avelumab + axitinib arm from the first interim analysis of JAVELIN Renal 101 were analyzed (data cutoff, June 20, 2018). Multivariate Cox regression analyses of PFS and OS were also conducted. Results: In the avelumab + axitinib arm, patients with &lt; median NLR (N = 217) had longer observed PFS (stratified HR, 0.85; 95% CI, 0.634, 1.153) and longer observed OS (stratified HR, 0.51; 95% CI, 0.300, 0.871) than patients with ≥ median NLR (N = 217). The ORR was 57.1% in patients with &lt; median NLR vs 47.5% in patients with ≥ median NLR, with complete response in 5.5% vs 1.4%. Multivariate analysis showed that low NLR was associated with longer PFS and OS by treating baseline NLR as either a continuous variable or a binary variable (dichotomized by median). Conclusions: Low NLR was associated with better observed treatment outcomes in patients with aRCC who received avelumab + axitinib. Clinical trial information: NCT02684006 .
Sulfur-Tolerant Ceramic Anodes for Solid Oxide Fuel Cells (2004)

Alternative anode materials with properties superior to Ni-YSZ are being exploited in this paper. These materials are comprised of mixtures of doped SrTiO3 and doped CeO2, possess good compatibility with an YSZ electrolyte and demonstrate excellent dimensional and chemical stability under thermal and reduction-oxidation cycling. These oxide composites exhibit excellent electrocatalytic activity for hydrogen oxidation in the temperature range 700-950oC. The effect of sulfur impurities in the hydrogen fuel on electrolyte-supported cell performance was studied. Hydrogen sulfide, 50-1,000 ppm, was introduced into the fuel gas and maintained for up to 500 hours. High sulfur contents, 1000 ppm, resulted in 40% performance loss. However, after turning H2S off and supplying the anode with wet hydrogen only, cell performance retuned to the initial value. No hot air or steam was required for the anode recovery. This indicates that the anode material under development is tolerant to sulfur poisoning under the conditions studied.
Designing High‐Performing Symmetric Supercapacitor by Engineering Polyaniline on Steel Mesh Surface via Electrodeposition (2022)

Energy storage is one of the most stimulating requirements to keep civilization on the wheel of progress. Supercapacitors generally exhibit a high-power density, have a maximum life cycle, quick charging time, and are eco-friendly. Polyaniline (PANI), a conductive polymer, is considered an efficacious electrode material for supercapacitors due to its good electroactivity, including pseudocapacitive behavior. Here, we present the fabrication of a symmetric supercapacitor device based on steel mesh electrodeposited with PANI. Due to its effective conductivity, porous nature, and low cost, steel mesh is a good choice as a current collector to fabricate a high-performance supercapacitor at a low cost. The optimum fabricated supercapacitor has a high specific capacitance of ∼353 mF cm<sup>-2</sup> . Furthermore, the supercapacitor obtained an energy density of ∼26.4 μW h cm<sup>-2</sup> at a power density of ∼400 μW cm<sup>-2</sup> . The fabricated supercapacitor shows high stability, as the initial capacitance remained almost the same after 1000 charge/discharge cycles. PANI is a promising candidate for mass production and wide applications due to its low cost and high performance.
Oncology: A Case-based Manual (1999)

Basic science of oncology Making management decisions Breast oncology Melanoma Haematological oncology Thoracic oncology Urological oncology Gastrointestinal oncology Gynaecological oncology Paediatric oncology Sarcoma and bone oncology Head, neck, and central nervous system oncology Managing the end of life
PD and PDT for hepatoblastoma? Preclinical considerations (2011)

Objective: Provide preclinical data on the feasibility of 5-aminolevulinic acid (5-ALA) -based photodetection (PD) and Photodynamic Therapy (PDT) of early childhood tumors.Methods: Hepatoblastoma (HuH6), neuroblastoma (MHH-NB11) and N1-fibroblast cell lines were tested for their relative capacities to synthesize Protoporphyrin IX (PpIX) from 5-ALA and for their susceptibility to PDT in vitro. HuH6-cells were also inoculated in the peritoneum of rats. The pharmacokinetics of porphyrin accumulation was measured in 9 rats by laparoscopic spectroscopy. 5-ALA was applied by i.p. injection of 500 mg/kg bw. In another 21 animals, tumors (n=20), liver (n=5) and peritoneum (n=4) were treated by PDT laparoscopically. 48 h after irradiation, animals were again incubated with 5-ALA and then sacrificed and tissues were removed for further investigation.Results: Both tumor cell lines showed higher levels of porphyrin fluorescence than the fibroblasts. Cell viability testing proved the HuH6 cells to be most susceptible to PDT. Pharmacokinetic measurements of PpIX in xenografted tumors showed a peak at 80-200 min after i.p. injection of 5-ALA. Irradiation resulted in pronounced photobleaching at all irradiated sites and necrosis of tumor and liver tissue, whereas peritoneum appeared to remain unaffected. Necrosis induced by PDT could be seen in fluorescence microscopy due to the lack of porphyrin synthesis in necrotic tissue after the re-incubation with 5-ALA.
Multiuser detection for vector multiple access channels using generalized decision feedback equalization (2002)

This paper considers the optimal multiuser detection problem for the vector Gaussian multiple access channel with multiple inputs and multiple outputs (MIMO). A practical bit-loading and multiuser decision feedback scheme based on generalized decision feedback equalization (GDFE) is proposed. This GDFE-based detection scheme, when used with an optimized transmitter, achieves the extreme points in the multiple access channel capacity region.
Optical characterization of anisotropic MoS&lt;inf&gt;2&lt;/inf&gt; nanosheets (2017)

Two-dimensional transition metal dichalcogenide (MX <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) are receiving lot of attention in recent years due to their excellent electronic and optical properties which make them feasible for advanced photonics applications [1]. In particular Molybdenum-Disulfide (MoS <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) has shown large exciton binding energy, strong spin-orbit interaction, and high carrier mobilities.
Food intake and oral sucrose in preterms prior to heel prick (2002)

To investigate the soothing effect of feeding on infants in distress, the effects of 2 mL 15% and 1 mL 25% sucrose given orally 2 min before heel prick in fasting preterms to reduce the pain response were assessed. The effects of milk intake by nasogastric tube were also assessed once during the last hour before heel prick, and the effects of milk intake by nasogastric tube once during the last hour before heel prick together with 1 mL 25% sucrose given orally 2 min before heel prick. The pain response was measured as changes in crying time, behavioural state, skin conductance and heart rate. Each group included 12 healthy preterm infants with a median gestational age of 32 wk and a median postnatal age of 14 d. These infants were randomly studied twice; one in connection with the intervention and once after being given sterilized water. Differences in the measured variables before and during heel prick showed that only the crying time was reduced when the infants received milk or 25% sucrose prior to heel prick (p < 0.05). If the infants received milk and 25% sucrose before heel prick, the crying time and the level of behavioural state were reduced (p < 0.05). The increase from before to during heel prick in skin conductance (number and amplitude of the waves) and heart rate correlated with the crying time (p < 0.01).
Improving the Suction Performance and Stability of an Inducer with an Integrated Inlet Cover Bleed System Known as a Stability Control Device (2015)

The performance of an inducer with the integration of an inlet cover bleed system known as a stability control device (SCD) is investigated using computational fluid dynamics. Inducers are the first stage of high suction performance pumps and are designed to operate under cavitating conditions. Improvements in design have allowed inducers to operate stably with low inlet head conditions, however, cavitation instabilities ultimately lead to pump failure. It has been shown that inducers that employ an SCD fully suppress cavitation instabilities.The performance of an inducer is explored at both on- and off-design flow coefficients, where the flow coefficient is a normalized flow rate through the inducer. Both the cavitating and non-cavitating performance of the inducer are analyzed. Improved stability is observed when the SCD is implemented, particularly at flow coefficients below the design value. The stabilizing effect of the SCD allows the inducer to operate stably at much lower flow coefficients, which allows for significant improvements in the pumps ability to operate with minimal inlet head. Cavitation instabilities, such as rotating cavitation, are also suppressed when the SCD is implemented.As part of this work, the design space created by the SCD is explored. Variations in the SCD geometry as well as the inlet blade angle of the inducer are explored. High suction performance pumps are required to operate at very low flow coefficients in order to have the best suction performance. Traditionally, only inducers with small inlet blade angles can maintain stable operation at very low flow coefficient. Because of the stabilizing effect of an SCD, inducers with larger inlet blade angles can now operate stably at the low flow rates require for high suction performance pumps. The influence of varying the inlet blade angle is explored in inducers that employ an SCD. This provides a better understanding of the flow physics in inducers that employ an SCD and help to define their design criteria. Stable operation at low flow coefficients is achieved with the larger inlet blade angles, confirming that inducers with larger inlet blade angles that employ an SCD can be used in high suction performance pumps. Modifications to the SCD geometry are considered to better optimize the design. Variations in the SCD geometry have almost no effect on the cavitation breakdown curve for each inducer, however, the stability of the pumps is greatly influenced by the SCD geometry. Some cavitation instabilities are observed in inducers that operate with an SCD. The physics that leads to the generation of these instabilities is unique to an inducer with an SCD. Modifications to the SCD geometry can allow inducers that employ an SCD to suppress traditional cavitation instabilities that occur without an SCD as well as the new instabilities that are observed when an SCD is implemented.
Selected Clostridia Strains from The Human Microbiota and their Metabolite, Butyrate, Improve Experimental Autoimmune Encephalomyelitis (2021)

Gut microbiome studies in multiple sclerosis (MS) patients are unravelling some consistent but modest patterns of gut dysbiosis. Among these, a significant decrease of Clostridia cluster IV and XIVa has been reported. In the present study, we investigated the therapeutic effect of a previously selected mixture of human gut-derived 17 Clostridia strains, which belong to Clostridia clusters IV, XIVa, and XVIII, on the clinical outcome of experimental autoimmune encephalomyelitis (EAE). The observed clinical improvement was related to lower demyelination and astrocyte reactivity as well as a tendency to lower microglia reactivity/infiltrating macrophages and axonal damage in the central nervous system (CNS), and to an enhanced immunoregulatory response of regulatory T cells in the periphery. Transcriptome studies also highlighted increased antiinflammatory responses related to interferon beta in the periphery and lower immune responses in the CNS. Since Clostridia-treated mice were found to present higher levels of the immunomodulatory short-chain fatty acid (SCFA) butyrate in the serum, we studied if this clinical effect could be reproduced by butyrate administration alone. Further EAE experiments proved its preventive but slight therapeutic impact on CNS autoimmunity. Thus, this smaller therapeutic effect highlighted that the Clostridia-induced clinical effect was not exclusively related to the SCFA and could not be reproduced by butyrate administration alone. Although it is still unknown if these Clostridia strains will have the same effect on MS patients, gut dysbiosis in MS patients could be partially rebalanced by these commensal bacteria and their immunoregulatory properties could have a beneficial effect on MS clinical course.
Genetic mechanisms involved in the adaptation of marine algae to heavy metal pollution (1998)

Conference Article| May 01 1998 Genetic mechanisms involved in the adaptation of marine algae to heavy metal pollution Ceri A. Morris; Ceri A. Morris 1School of Molecular and Medical Biosciences, University of Wales Cardiff, P.O. Box 911, Cardiff CF1 3US Search for other works by this author on: This Site PubMed Google Scholar Beate Nicolaus; Beate Nicolaus 1School of Molecular and Medical Biosciences, University of Wales Cardiff, P.O. Box 911, Cardiff CF1 3US Search for other works by this author on: This Site PubMed Google Scholar Peter Kille; Peter Kille 1School of Molecular and Medical Biosciences, University of Wales Cardiff, P.O. Box 911, Cardiff CF1 3US Search for other works by this author on: This Site PubMed Google Scholar John L. Harwood John L. Harwood 1School of Molecular and Medical Biosciences, University of Wales Cardiff, P.O. Box 911, Cardiff CF1 3US Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1998) 26 (2): S153. https://doi.org/10.1042/bst026s153 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation Ceri A. Morris, Beate Nicolaus, Peter Kille, John L. Harwood; Genetic mechanisms involved in the adaptation of marine algae to heavy metal pollution. Biochem Soc Trans 1 May 1998; 26 (2): S153. doi: https://doi.org/10.1042/bst026s153 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1998 Biochemical Society1998 Article PDF first page preview Close Modal You do not currently have access to this content.
Supplementary Data from Erythropoietin Receptor Expression and Correlation to Tamoxifen Response and Prognosis in Breast Cancer (2023)

Supplementary Data from Erythropoietin Receptor Expression and Correlation to Tamoxifen Response and Prognosis in Breast Cancer
Trader Vic on Commodities: What's Unknown, Misunderstood, and Too Good to Be True (2008)

Preface. Acknowledgments. About the Author. Chapter 1. The Basics. Chapter 2. You Can't Win Them All. Chapter 3. Indicators and Tools. Chapter 4. 2B or Not 2B: A Classic Rule Revisited. Chapter 5. An Introduction to the S&P DTI. Chapter 6. A Challenge to the Random Walk Theory. Chapter 7. The Rationale and Value of a Long/Short Strategy. Chapter 8. Why the S&P DTI is an Indicator. Chapter 9. The Fundamental Reason the S&P DTI Generates Core Returns. Chapter 10. The Nature of the S&P DTI Returns. Chapter 11. A Fundamental Hedge. Chapter 12. S&P DTI Sub-Indices: The S&P Commodity Trends Indicator and the S&P Financial Trends Indicator. Afterward. Appendix A. Standard & Poor's Diversified Trends Indicator Methodology and Implementation. Appendix B. How to Interpret Simulated Historical Results. Index.
Apoptosis detection via automated algorithms to analyze biomarker translocation in reporter cells (2020)

Rapid, efficient, and robust quantitative analyses of dynamic apoptotic events are essential in a high-throughput screening workflow. Currently used methods have several bottlenecks, specifically, limitations in available fluorophores for downstream assays and misinterpretation of statistical image data analysis. In this study, we developed cytochrome-C (Cyt-C) and caspase-3/-8 reporter cell lines using lung (PC9) and breast (T47D) cancer cells, and characterized them from the response to apoptotic stimuli. In these two reporter cell lines, the spatial fluorescent signal translocation patterns served as reporters of activations of apoptotic events, such as Cyt-C release and caspase-3/-8 activation. We also developed a vision-based, tunable, automated algorithm in MATLAB to implement the robust and accurate analysis of signal translocation in single or multiple cells. Construction of the reporter cell lines allows live monitoring of apoptotic events without the need for any other dyes or fixatives. Our algorithmic implementation forgoes the use of simple image statistics for more robust analytics. Our optimized algorithm can achieve a precision greater than 90% and a sensitivity higher than 85%. Combining our automated algorithm with reporter cells bearing a single-color dye/fluorophore, we expect our approach to become an integral component in the high-throughput drug screening workflow.
Brain‐derived neurotrophic factor modulates GAP‐43 but not tα1 expression in injured retinal ganglion cells of adult rats (1997)

The administration of neurotrophins affects neuronal survival and growth, but less is known about their ability to modify the expression of growth associated genes following injury to CNS neurons. Here we characterize the effect of brain-derived neurotrophic factor (BDNF) on mRNA levels for Tα1 α-tubulin, and for GAP-43, two genes whose expression levels in retinal ganglion cells (RGC) tend to correlate with growth. We first determined that most adult rat RGCs can retrogradely transport BDNF by injecting 125I-BDNF into RGC target sites in vivo. We then used quantitative in situ hybridization to characterize the effect of axotomy, or axotomy and BDNF administration on mRNA levels for GAP-43 and Tα1. Axotomy alone resulted in a general decrease in Tα1 α-tubulin mRNA levels by 2 weeks, and elicited an increase in GAP-43 mRNA levels in an average of 30% of surviving RGCs. The intravitreal administration of a single dose of BDNF (5 μg) to axotomized RGCs on the day of injury did not affect Tα1 α-tubulin mRNA levels, but was followed by a moderate (approximately 80%), and short-lasting enhancement of GAP-43 mRNA levels in most RGCs during the first week after axotomy. No significant increase in GAP-43 mRNA levels was observed when BDNF was injected into the uninjured eye. We conclude that BDNF specifically enhances GAP-43 but not Tα1 mRNA levels in injured RGCs. Because BDNF is known to stimulate branch length of injured RGCs, we suggest that changes in the expression of GAP-43, but not Tα1 tubulin, correlate with branching of injured neurons as opposed to long distance regrowth. J. Neurosci. Res. 47:561–572, 1997. © 1997 Wiley-Liss, Inc.
Linear Multiuser MIMO Transmission with Quality of Service and Per Antenna Power Constraints (2007)

Joint design of linear multiuser multiple-input multiple-output (MIMO) transceiver subject to different quality of service constraints per user and with per antenna or antenna group power constraints is considered. A solution for finding a maximum weighted common rate achievable for each scheduled user with minimum rate requirements per user is proposed. The proposed joint transceiver optimization algorithms are compared to corresponding optimal nonlinear transmission methods as well as to zero forcing transmission solutions. The proposed algorithms provide efficient solutions for difficult non-convex transceiver optimization problems.