gebhart/patrepeval huggingface dataset:
Supplementary Tables 1-10 from microRNA Regulatory Network Inference Identifies miR-34a as a Novel Regulator of TGF-β Signaling in Glioblastoma (2023)

&lt;p&gt;PDF file - 1.1MB, Supplementary Table 1: list of 290 TCGA samples used in the study. Supplementary Table 2: list of miR-mRNA edges identified by CLR. Supplementary Table 3: list of putative direct miR-mRNA edges in the network. Supplementary Table 4: miR-mRNA edges identified as unique to each of the 4 molecular subtypes. (A) Classical (B) Neural (C) Proneural (D) Mesenchymal. Supplementary Table 5: miR and mRNA nodes in regions of copy number aberration in the sub-network corresponding to the 8 discriminatory miRs. Supplementary Table 6: survival analysis results for the 8 discriminatory miRs. Supplementary Table 7: multivariate Cox regression analysis in the TCGA dataset and in the 4 molecular subclasses. Supplementary Table 8: patients' characteristics (validation cohort, n=220). Supplementary Table 9: AQUA values (raw data) for miR-34a expression in Glioblastoma TMAs (validation cohort). Supplementary Table 10: list of transcription factors enriched in the PN subtype&lt;/p&gt;
Central retinal vein occlusion: a prospective histopathologic study of 29 eyes in 28 cases. (1981)

The clinical and histopathologic features of 29 eyes from 29 patients with central retinal vein occlusion (CRVO) are reported. A fresh or a recanalized thrombus was observed in each eye. This study considers the temporal aspects of the cases, and it notes the different morphologic features of the occlusion. These observations explain most of the variability of the changes observed in previous reports. We believe that these different features represent the various stages in the natural evolution of such a thrombus. The interval between CRVO and histopathologic study in our series ranged from six hours to more than 10 years. Local and systemic factors were reviewed and were found to be important in the pathogenesis of thrombus formation. Local diseases with a predisposing effect on CRVO included: glaucoma, papilledema, subdural hemorrhage, optic nerve hemorrhage, and drusen of the optic nerve head. Associated systemic diseases included: hypertension, cardiovascular and cerebrovascular disease, diabetes mellitus, and leukemia with thrombocytopenia. A fresh thrombus in the CRVO was observed in three (10.3%), and a recanalized thrombus in 26 eyes (89.7%). Endothelial-cell proliferation was a conspicuous feature in 14 (48.3%) of the eyes. Chronic inflammation in the area of the thrombus, and/or vein wall or perivenular area was observed in 14 (48.3%) of the eyes. Arterial occlusive disease was observed in seven eyes (24.6%). Cystoid macular edema was found in 26 (89.7%) of the eyes.
Inside Back Cover: Improved and General Manganese‐Catalyzed N‐Methylation of Aromatic Amines Using Methanol (Chem. Eur. J. 23/2017) (2017)

A manganese PNP-pincer complex was developed as a suitable catalyst for the selective mono-methylation of aromatic amines with inexpensive methanol. Using borrowing hydrogen methodology, a selection of different aniline derivatives was selectively methylated, tolerating functional groups such as ketone, C=C double bonds, or amides. The novel manganese PNP-pincer complex allowed for methylations under mild conditions in high yields. More information can be found in the Communication by M. Beller, et al. on page 5410 ff.
Novel simian immunodeficiency virus CTL epitopes restricted by MHC class I molecule Mamu-B*01 are highly conserved for long term in DNA/MVA-vaccinated, SHIV-challenged rhesus macaques (2005)

Simian immunodeficiency virus (SIV) infection of rhesus macaques provides an excellent model for investigating the basis of protective immunity against human immunodeficiency virus (HIV). One limitation of this model, however, has been the availability of a small number of known MHC class I-restricted CTL epitopes for investigating virus-specific immune responses. We assessed CTL responses against SIV Gag in a cohort of DNA/modified vaccinia virus Ankara (MVA)-vaccinated/ simian-human immunodeficiency virus (SHIV)-challenged rhesus macaques. Here, we report the identification of five novel SIV CTL epitopes in Gag for the first time (Gag 39-46 NELDRFGL, Gag 169-177 EVVPGFQAL, Gag 198-206 AAMQIIRDI, Gag 257-265 IPVGNIYRR and Gag 296-305 SYVDRFYKSL) that are restricted by the common MHC class I molecule Mamu-B*01. CTL responses to these epitopes were readily detected in cryopreserved PBMC in multiple animals up to 62 weeks post-infection, both by IFN-c enzyme-linked immunospot assay and intracellular IFN-c staining. Importantly, viral sequencing results revealed that these epitopes are highly conserved in the SIV-challenged macaques over a long period of time, indicating functional constraints in these regions. Moreover, the presence of CTL responses targeting these epitopes has been confirmed in two independent cohorts of rhesus macaques that have been challenged by SHIV or SIV. Our findings provide valuable candidates for poly-epitope vaccines and for long-term quantitative monitoring of epitope-specific CD8 1 responses in the context of this common Mamu class I allele. It may thus help increase the supply of rhesus macaques in which epitope-specific immunity can be studied in the context of SIV vaccine design.
Optimization of frequency selective absorbers for sub-mm security imagers (2016)

In the FP7 project CONSORTIS, a dual-band passive imager is being developed for security applications. The latter is based on bolometer based kinetic inductance detectors operating at two frequency bands to improve the collection of thermal information. These bolometric detectors rely on a frequency selective absorber (FSA) to achieve the two bands. In this contribution, we describe the optimization of the FSA and focal plane architecture to achieve imaging of a full body with high sensitivity (<;1K) and large frame rate (10Hz).
Synthesis of hybrid semiconducting polymer–metal latexes (2012)

Well-defined hybrid latex materials composed of a semi-conducting polymer (i.e. poly(3,4-ethylene dioxythiophene) (PEDOT)) and metal nano-objects (such as silver (Ag) or gold (Au)) were prepared by aqueous dispersion polymerization using ammonium persulfate as an oxidant and the corresponding metal salts as co-oxidants (HAuCl4 and AgNO3 respectively) in the presence of various reactive stabilizers such as aniline-modified-poly(vinyl alcohol) (PVAL-mod-An), pyrrole-modified-poly(vinyl alcohol) (PVAL-mod-Py), pyrrole-modified-poly(N-vinylpyrrolidone-co-vinyl alcohol) (PVP-co-PVAL-mod-Py), or α,ω-fluorene-poly(ethyleneoxide) (Flu-PEO-Flu). The effects of the nature and concentration of the reactive stabilizers as well as the addition time of the co-oxidant on the morphology of the hybrid nanoparticles thus formed are discussed. It is found that the addition time of the co-oxidant affects considerably the size and morphology of the PEDOT–metal nanocomposites.
Foreword (2005)

It is with great pleasure that we dedicate this issue of the Applied Organometallic Chemistry to our very good friend, the late Professor Colin Eaborn of the University of Sussex, in memory of his contribution not only to the chemistry of germanium, tin and lead, but also the main group organometallic chemistry in general.Originally, this issue was planned as proceedings of the XIth International Conference on the Coordination and Organometallic Chemistry of Germanium, Tin and Lead (ICCOC-GTL-XI) held at Radisson Hotel, Santa Fe, New Mexico, 27 June-2 July 2004.However, since much of the chemistry presented at the conference was closely related to silicon and other main group elements it is appropriate that this special issue be dedicated to the organometallic chemistry of the Group 14 elements, if not all of the main group elements.Who bettter than Colin Eaborn to deserve this honor, since his entire career was dedicated to this area of chemistry?His studies brought a new meaning to the 'Main Group Metal Chemistry'.Colin, although you will never know about this special issue, you have had a remarkably fruitful career and have rightfully earned the respect and admiration of your colleagues in science throughout the world.We salute you and dedicate this special issue to you in recognition of your outstanding contributions to main group organometallic and inorganic chemistry.
Genetic Variants in <i>HSD17B3</i>, <i>SMAD3</i>, and <i>IPO11</i> Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes (2017)

Individuals with type 2 diabetes (T2D) and dyslipidemia are at an increased risk of cardiovascular disease. Fibrates are a class of drugs prescribed to treat dyslipidemia, but variation in response has been observed. To evaluate common and rare genetic variants that impact lipid responses to fenofibrate in statin-treated patients with T2D, we examined lipid changes in response to fenofibrate therapy using a genomewide association study (GWAS). Associations were followed-up using gene expression studies in mice. Common variants in SMAD3 and IPO11 were marginally associated with lipid changes in black subjects (P < 5 × 10<sup>-6</sup> ). Rare variant and gene expression changes were assessed using a false discovery rate approach. AKR7A3 and HSD17B13 were associated with lipid changes in white subjects (q < 0.2). Mice fed fenofibrate displayed reductions in Hsd17b13 gene expression (q < 0.1). Associations of variants in SMAD3, IPO11, and HSD17B13, with gene expression changes in mice indicate that transforming growth factor-beta (TGF-β) and NRF2 signaling pathways may influence fenofibrate effects on dyslipidemia in patients with T2D.
Industry Updates from the Field of Stem Cell Research and Regenerative Medicine in February 2020 (2020)

The latest developments in the field of stem-cell research and regenerative medicine compiled from publicly available information and press releases from nonacademic institutions in February 2020.
Highly enantioselective epoxidation of styrenes: Implication of an electronic effect on the competition between spiro and planar transition states (2004)

Asymmetric epoxidation of various styrenes using carbocyclic oxazolidinone-containing ketone 3 has been investigated. High enantioselectivity (89-93% enantiomeric excess) has been attained for this challenging class of alkenes. Mechanistic studies show that substituents on the ketone catalyst can have electronic influences on secondary orbital interactions, which affects the competition between spiro and planar transition states and, ultimately, enantioselectivity. The results described herein not only reveal the potential of chiral dioxirane catalyzed asymmetric epoxidation as a viable entry into this important class of olefins but also further enhance the understanding of the mechanistic aspects of chiral ketone-catalyzed asymmetric epoxidation.
SIKA: A Decentralized Architecture for Knowledge Grid Resource Management (2008)

Grid system has facilitated large scale, flexible, distributed, secure and coordinated resource sharing. It aims to make full use of the network resources and build a harmonious collaborative community. However, resource management and quick resource location are still urgent problems for grid systems, especially under large, dynamic environment. This paper presents SIKA a grid-based overlay network for knowledge grid system. It groups the nodes into domain sensitive communities, but by defining new inter community organization mechanism, it successfully avoids using super peers. The main characteristics of this architecture are highlighted by its convenience for community analysis, promising scalability, itssearch efficiency, as well as its robustness. The experimental performance results presented here demonstrate the efficiency of the design.
(Digital Presentation) Room Temperature Pseudo-Solid State Conversion Battery (2022)

Herein, we report a pseudo-solid state conversion battery that operates at room temperature. Elimination of a traditional separator is enabled by the use of a polymer gel filled with a localized high concentration electrolyte (LHCE). This pairing combines the benefits of a flexible separator (e.g., adaptation to conversion-related volume changes) with the advantages of an LHCE (e.g., suppression of side reactions). The high ionic conductivity of the LHCE-filled gel facilitates room temperature operation of these batteries. To the best of our knowledge, this is in contrast to previous reports of pseudo-solid state batteries constructed with a similar conversion cathode material. Overall, we demonstrate three key properties. First, conversion batteries containing the LHCE-filled gel have high rate capabilities at room temperature. Second, the LHCE-filled gel is found to be stable with both the anode and cathode. Third, cycling performance with the LHCE-filled gel is nearly identical to that of a traditional separator, over a range of current densities (0.05-1.0 mA/cm 2 ). This result underscores the viability of the former to serve as an alternative for the latter.
Wasserlösliche Phosphane, III [1]. Wasserlösliche primäre Phosphane mit Ammoniumgruppierungen NR<sub>2</sub>R' in der Seitenkette -donorfunktionalisierte Amphiphile / Water-Soluble Phosphanes, III [1]. Water-Soluble Primary Phosphanes with Ammonium Groups NR<sub>2</sub>R' in the Side Chain -Donor-Functionalized Amphiphiles (1994)

Primary and secondary aminoalkylphosphanes R 2 N-(CH2) m -PH 2 (R 2 = Me 2 , nBu 2 , C 5 H 10 , C 4 H 8 O, 2-(1-Methyl-2-pyrrolidinyl); m = 2, 3, 6, 10, 11; 1-6) or [R 2 N-(CH 2 ) m ] 2 PH (7, R 2 = C 5 H 10 ; m = 2) are accessible by aminoalkylation of PH 3 with ω̃ -chloroalkylamines R 2 N-(CH 2 ) m -Cl in the superbasic medium DMSO/KOH (DMSO = dimethylsulfoxide). By selective N-quaternization of 1, 2, 4-6 with R'I (R' = Me, C n H 2n+1 ; n = 6-8, 12, 16, 18) in the two-phase system CH 2 Cl 2 /H 2 O novel primary phosphanes [R'R 2 N-(CH 2 ) m -PH 2 ] + I - (11-16f) with quaternary ammonium groups in the alkyl side chain are obtained. The water solubility of 11-16f decreases with increasing chain length (n) of R′ 11 (R = R' = Me; m = 2) shows a trans conformation at the C 2 H 4 bridge according to an X-ray structural analysis. Protonation of 1, 2, 4, 5 with HCl affords the water-soluble hydrochlorides [HR 2 N-(CH 2 ) m -PH 2 ] + Cl - (19-22). The cationic primary phosphanes 11-16f are stable towards oxygen. By oxidation of 11 with one or two equivalents of H 2 O 2 the primary phosphane oxide [Me 3 N-(CH 2 ) 2 -P(O)H 2 ] + I - (23) or the phosphonous acid [Me 3 N-(CH 2 ) 2 - P(O)(OH)H] + I - (23a) are formed. Hofmann degradation of 11 or 16c with KOH yields phosphirane in good yields. Reaction of 1, 2, 4-6 (L) with Fe 2 (CO) 9 at ambient temperature yields stable complexes (CO) 4 FeL (26-30). Under more rigorous conditions Fe 3 clusters (31, 32) with free R 2 N groups are obtained.
Relative Pancreas Volume Is Reduced in Autoantibody Negative First-Degree Relatives and Subjects with Pre–Type 1 Diabetes (2018)

Pancreatic size is significantly reduced in new-onset type 1 diabetes (T1D) patients and one study reported decreased weight in T1D-related autoantibody (AAb) positive nondiabetic organ donors. We proposed that pancreas volume (PV) could provide important information regarding progression to T1D onset. The relationship between PV and autoantibody status was determined. Study design included 4 groups: T1D patients &amp;lt; 1 year of diagnosis; AAb+ first-degree relatives (FDR); AAb- FDR; and AAb- controls. Fasting subjects underwent pancreas magnetic resonance imaging (MRI) and images were analyzed by radiologists blinded to group. Relative PV (RPV=PV/BMI) was analyzed utilizing a linear mixed model accounting for age, gender, and family clustering with Tukey correction for multiple comparisons. A total of 223 subjects were enrolled with overall age of 19.6±10.5 years (45% males). RPV was significantly higher in controls (n=49) than AAb- FDR (n=60), AAb+ FDR (n=62 (single AAb+ n=30, multiple AAb+ n=32)) and recent onset T1D (n=52) (Figure). RPV was also significantly higher in AAb- FDR and AAb+ FDR vs. recent onset T1D (Figure). Pancreas MRI demonstrates smaller RPV in AAb- FDR than age-matched controls and patients with recent onset T1D have lower RPV than those FDR with established autoimmunity. Pancreas MRI may improve our understanding of the natural history of T1D. Disclosure M. Campbell-Thompson: None. M.A. Atkinson: Other Relationship; Self; Patent Issued. S.L. Filipp: None. M.J. Gurka: None. R. Beegle: None. D. Schatz: None. M.J. Haller: None.
Oxygen concentration dependence of silicon oxide dynamical properties (2018)

To understand oxidation in three-dimensional silicon, dynamic characteristics of a SiOx system with various stoichiometries were investigated. The calculated results show that the self-diffusion coefficient increases as oxygen density decreases, and the increase is large when the temperature is low. It also shows that the self-diffusion coefficient saturates, when the number of removed oxygen atoms is sufficiently large. Then, approximate analytical equations are derived from the calculated results, and the previously reported expression is confirmed in the extremely low-SiO-density range.
Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity (2008)

The activity of the homeobox gene Prox1 is necessary and sufficient for venous blood endothelial cells (BECs) to acquire a lymphatic endothelial cell (LEC) fate. We determined that the differentiated LEC phenotype is a plastic, reprogrammable condition that depends on constant Prox1 activity for its maintenance. We show that conditional down-regulation of Prox1 during embryonic, postnatal, or adult stages is sufficient to reprogram LECs into BECs. Consequently, the identity of the mutant lymphatic vessels is also partially reprogrammed as they acquire some features typical of the blood vasculature. siRNA-mediated down-regulation of Prox1 in LECs in culture demonstrates that reprogramming of LECs into BECs is a Prox1-dependent, cell-autonomous process. We propose that Prox1 acts as a binary switch that suppresses BEC identity and promotes and maintains LEC identity; switching off Prox1 activity is sufficient to initiate a reprogramming cascade leading to the dedifferentiation of LECs into BECs. Therefore, LECs are one of the few differentiated cell types that require constant expression of a certain gene to maintain their phenotypic identity.
A Structured Hardware/Software Architecture for Embedded Sensor Nodes (2008)

Owing to the limited requirement for sensor processing in early networked sensor nodes, embedded software was generally built around the communication stack. Modern sensor nodes have evolved to contain significant on-board functionality in addition to communications, including sensor processing, energy management, actuation and locationing. The embedded software for this functionality, however, is often implemented in the application layer of the communications stack, resulting in an unstructured, top-heavy and complex stack. In this paper, we propose an embedded system architecture to formally specify multiple interfaces on a sensor node. This architecture differs from existing solutions by providing a sensor node with multiple stacks (each stack implements a separate node function), all linked by a shared application layer. This establishes a structured platform for the formal design, specification and implementation of modern sensor and wireless sensor nodes. We describe a practical prototype of an intelligent sensing, energy-aware, sensor node that has been developed using this architecture, implementing stacks for communications, sensing and energy management. The structure and operation of the intelligent sensing and energy management stacks are described in detail. The proposed architecture promotes structured and modular design, allowing for efficient code reuse and being suitable for future generations of sensor nodes featuring interchangeable components.
Performance Models for LAS-based Scheduling Disciplines in a Packet Switched Network (2004)

The Least Attained Service (LAS) scheduling policy, when used for scheduling packets over the bottleneck link of an Internet path, can greatly reduce the average flow time for short flows, while not significantly increasing the average flow time for the long flows that share the same bottleneck. No modification of the packet headers is required to implement the simple LAS policy. However, previous work has also shown that a drawback of the LAS scheduler is that, when link utilization is greater than 70%, long flows experience large jitter in their packet transfer times as compared to the conventional First-Come-First-Serve (FCFS) link scheduling. This paper proposes and evaluates new differentiated LAS scheduling policies that reduce the jitter for long flows that are identified as &amp;quot;priority&amp;quot; flows.
Design of a Battery Carrying Barge for Enhancing Autonomous Sailboat's Endurance Capacity (2021)

This paper provides a new scheme to improve the sailing distance and working time of the autonomous sailboat. The main part of the article introduces a new design of sail tug which can carry more batteries that provides more power for control system, enabling sailboats to sail longer in both time and distance. The modified sail tug was tested at an advanced test site equipped with high precision infrared motion capture system. The air curtain machines in test site can produce constant wind field, to drive sailboat steadily. Comparative experiments have been conducted to show the advantages of self-supporting ability of autonomous sail tug over ordinary autonomous sailboat.
Lack and overexpression of Trxo1 in Arabidopsis affect mitochondrial metabolism and photosynthetic process under salinity (2019)

Trabajo presentado a la XXIII Reunión Bianual de la Sociedad Española de Fisiología Vegetal y al XVI Congreso Hispano-Luso de Fisiología Vegetal, celebrados en Pamplona (España) del 26 al 28 de junio de 2019.
ChemInform Abstract: C‐Acylnitrilium Ion Initiated Cyclizations in Heterocycle Synthesis (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Structure/Function Relationships in Dyes for Solar Energy Conversion: A Two-Atom Change in Dye Structure and the Mechanism for Its Effect on Cell Voltage (2009)

Recombination between injected electrons and iodine limits the photovoltage in dye-sensitized solar cells (DSSCs). We have recently suggested that many new dye molecules, intended to improve DSSCs, can accelerate this reaction, negating the expected improvement (J. Am. Chem. Soc. 2008, 130, 2907). Here we study two dyes with only a two-atom change in the structure, yet which give different Vocs. Using a range of measurements we show conclusively that the change in Voc is due solely to the increase in the recombination rate. From the structure of the dyes, and literature values for iodine binding of similar compounds, we find that it is very likely that the change in Voc is due solely to the difference in iodine binding at the site of the two-atom change. Using the large amount of literature on iodine complexation, we suggest structures for dyes that might show improved Voc.