gebhart/patrepeval huggingface dataset:
Synthetic Entry into Polynuclear Bismuth–Manganese Chemistry: High Oxidation State Bi<sup>III</sup><sub>2</sub>Mn<sup>IV</sup><sub>6</sub> and Bi<sup>III</sup>Mn<sup>III</sup><sub>10</sub> Complexes (2011)

The first high nuclearity, mixed-metal Bi(III)/Mn(IV) and Bi(III)/Mn(III) complexes are reported. The former complexes are [Bi(2)Mn(IV)(6)O(9)(O(2)CEt)(9)(HO(2)CEt)(NO(3))(3)] (1) and [Bi(2)Mn(IV)(6)O(9)(O(2)CPh)(9)(HO(2)CPh)(NO(3))(3)] (2) and were obtained from the comproportionation reaction between Mn(O(2)CR)(2) and MnO(4)(-) in a 10:3 ratio in the presence of Bi(NO(3))(3) (3 equiv) in either a H(2)O/EtCO(2)H (1) or MeCN/PhCO(2)H (2) solvent medium. The same reaction that gives 2, but with Bi(O(2)CMe)(3) and MeNO(2) in place of Bi(NO(3))(3) and MeCN, gave the lower oxidation state product [BiMn(III)(10)O(8)(O(2)CPh)(17)(HO(2)CPh)(H(2)O)] (3). Complexes 1 and 2 are near-isostructural and possess an unusual and high symmetry core topology consisting of a Mn(IV)(6) wheel with two central Bi(III) atoms capping the wheel on each side. In contrast, the [BiMn(III)(10)O(8)](17+) core of 3 is low symmetry, comprising a [BiMn(3)(μ(3)-O)(2)](8+) butterfly unit, four [BiMn(3)(μ(4)-O)](10+) tetrahedra, and two [BiMn(2)(μ(3)-O)](7+) triangles all fused together by sharing common Mn and Bi vertices. Variable-temperature, solid-state dc and ac magnetization data on 1-3 in the 1.8-300 K range revealed that 1 and 2 possess an S = 0 ground state spin, whereas 3 possesses an S = 2 ground state. The work offers the possibility of access to molecular analogs of the multifunctional Bi/Mn/O solids that are of such great interest in materials science.
Creating a Sustainable Obesity Management Program: The Center for Better Health and Nutrition. (2016)

Over the past 30 years, obesity rates have more than tripled in the United States, and although rates seem to have stabilized over the past 5 years, about one- third of American children are still overweight or obese. The Center for Better Health and Nutrition (CBHN) is a comprehensive obesity treatment, manage- ment, and prevention arm of the Heart Institute within Cincinnati Children's Hospital Medical Center, offering necessary medical treatment to an often un- derserved population. With volumes increasing at substantial levels and services being reimbursed at low rates, the financial health of the program has been closely analyzed in order to determine the long-term sustainability of CBHN. Downstream revenue was analyzed and found to account for over $754,000 in fiscal year (FY) 2015; quality improvement efforts such as E/M coding and imple- menting the Nurse Practitioner role also added to increased revenue and a lower cost profile. Capturing all billable services, such as biometric measurement, was found to be valuable to the program's bottom line. By considering all applicable revenue sources, implementing quality improvement efforts, and billing for all relevant services, the program operates at a low level of profitability.
Optimizing Discrete Multi-tone Transmission for 400G Data Center\n Interconnects (2020)

Discrete multi-tone transmission (DMT) is a promising candidate for future\n400G data center interconnects. Eight channels, each carrying 56 Gb/s of data\ncan be combined in a 50-GHz channel grid to form a 400 Gb/s superchannel. For a\nfully loaded 96 channel DWDM system this leads to a total capacity of 4.8 Tb/s.\nTo meet the requirements of the targeted application in terms of cost\nefficiency and low power consumption, it is important to keep the complexity\nfor the digital signal processing as low as possible. For DMT, the complexity\nis mainly determined by the length of the fast Fourier transformation (FFT).\nSince data center interconnects only have to bridge a distance of typically 80\nkm, we here investigate among other parameters the influence of the FFT length\namong other parameters on the achievable performance for 56 Gb/s DMT only for\nthis distance. Transmission is performed in C-band to enable DWDM and no\noptical dispersion compensation is applied. We consider double sideband (DSB)\nas well as vestigial sideband (VSB) DMT. It can be seen that an FFT length of\n128 is sufficient to reach the required performance in terms of bit error\nratio, however, a higher length can significantly improve the performance.\n
Reply to Wilkinson et al.: Concerning the use of pHluorin-tagged GluA2 as a reporter for NMDA-induced AMPA receptor recycling (2014)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Affinity states of biocides determine bioavailability and release rates in marine paints (2015)

A challenge for the next generation marine antifouling (AF) paints is to deliver minimum amounts of biocides to the environment. The candidate AF compound medetomidine is here shown to be released at very low concentrations, ie ng ml(-1) day(-1). Moreover, the release rate of medetomidine differs substantially depending on the formulation of the paint, while inhibition of barnacle settlement is independent of release to the ambient water, ie the paint with the lowest release rate was the most effective in impeding barnacle colonisation. This highlights the critical role of chemical interactions between biocide, paint carrier and the solid/aqueous interface for release rate and AF performance. The results are discussed in the light of differential affinity states of the biocide, predicting AF activity in terms of a high surface affinity and preserved bioavailability. This may offer a general framework for the design of low-release paint systems using biocides for protection against biofouling on marine surfaces.
Total synthesis of halogenated monoterpene marine natural products via the Diels-Alder reaction (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of halogenated monoterpene marine natural products via the Diels-Alder reactionPaul G. Williard and Stephen E. De LaszloCite this: J. Org. Chem. 1985, 50, 20, 3738–3749Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00220a013https://doi.org/10.1021/jo00220a013research-articleACS PublicationsRequest reuse permissionsArticle Views675Altmetric-Citations27LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Traveling-Wave Mach-Zehnder Modulator Integrated With Electro-Optic Frequency-Domain Equalizer for Broadband Modulation (2023)

Broadband modulator is a key component of future high-capacity and high-baud-rate optical fiber communication. An electro-optic (EO) frequency-domain equalizer is proposed and investigated to increase the 3-dB bandwidth of optical modulators. The equalizer can be integrated with conventional traveling-wave modulators using a crossing waveguide, U-turn waveguide, or ferroelectric-domain-inversion. The 3-dB bandwidth of the modulator can be doubled by integrating the equalizer. As a theoretical consideration, we modeled several types of EO equalizers and investigated the function and parameter dependency of the equalizers in detail. For the experimental demonstration, a titanium-diffused lithium niobate optical waveguide modulator integrated with the EO equalizer was fabricated. The optical loss including fiber-coupling was as low as 5.4 dB, and the half-wave voltage was 3.7 V. The measured electro-optic response at 110 GHz is –0.4 dB, and that of the 3-dB bandwidth is larger than 110 GHz, which is the upper frequency limit of our measurement equipment. The 3-dB bandwidth of the modulator estimated using the fitting curve obtained from the measured electrical propagation loss of the modulator electrode was approximately 200 GHz.
Catalytic Asymmetric Cycloaddition of Ketenes and Nitroso Compounds: Enantioselective Synthesis of α‐Hydroxycarboxylic Acid Derivatives (2009)

Abstract Eine gute Wahl des chiralen Katalysators und der Ausgangsverbindungen ermöglicht den Aufbau von 1,2‐Oxazetidin‐3‐onen durch hoch regio‐ und enantioselektive Cycloadditionen von Ketenen mit Nitrosoverbindungen. Die Produkte sind für sich schon potenziell bioaktive Substanzen und können überdies in weitere wichtige Verbindungsklassen überführt werden, z. B. in α‐Hydroxycarbonsäure‐Derivate. magnified image
Prohibitin S-Nitrosylation Is Required for the Neuroprotective Effect of Nitric Oxide in Neuronal Cultures (2020)

Prohibitin (PHB) is a critical protein involved in many cellular activities. In brain, PHB resides in mitochondria, where it forms a large protein complex with PHB2 in the inner TFmembrane, which serves as a scaffolding platform for proteins involved in mitochondrial structural and functional integrity. PHB overexpression at moderate levels provides neuroprotection in experimental brain injury models. In addition, PHB expression is involved in ischemic preconditioning, as its expression is enhanced in preconditioning paradigms. However, the mechanisms of PHB functional regulation are still unknown. Observations that nitric oxide (NO) plays a key role in ischemia preconditioning compelled us to postulate that the neuroprotective effect of PHB could be regulated by NO. Here, we test this hypothesis in a neuronal model of ischemia-reperfusion injury and show that NO and PHB are mutually required for neuronal resilience against oxygen and glucose deprivation stress. Further, we demonstrate that NO post-translationally modifies PHB through protein S-nitrosylation and regulates PHB neuroprotective function, in a nitric oxide synthase-dependent manner. These results uncover the mechanisms of a previously unrecognized form of molecular regulation of PHB that underlies its neuroprotective function.<b>SIGNIFICANCE STATEMENT</b> Prohibitin (PHB) is a critical mitochondrial protein that exerts a potent neuroprotective effect when mildly upregulated in mice. However, how the neuroprotective function of PHB is regulated is still unknown. Here, we demonstrate a novel regulatory mechanism for PHB that involves nitric oxide (NO) and shows that PHB and NO interact directly, resulting in protein S-nitrosylation on residue Cys<sup>69</sup> of PHB. We further show that nitrosylation of PHB may be essential for its ability to preserve neuronal viability under hypoxic stress. Thus, our study reveals a previously unknown mechanism of functional regulation of PHB that has potential therapeutic implications for neurologic disorders.
Public Workshop Summary Report on Fiscal Year 2021 Generic Drug Regulatory Science Initiatives: Data Analysis and Model‐Based Bioequivalence (2020)

On May 4, 2020, the US Food and Drug Administration (FDA) hosted an online public workshop titled "FY 2020 Generic Drug Regulatory Science Initiatives Public Workshop" to provide an overview of the status of the science and research priorities and to solicit input on the development of Generic Drug User Fee Amendments fiscal year 2021 priorities. This report summarizes the podium presentations and the outcome of discussions along with innovative ways to overcome challenges and significant opportunities related to model-based approaches in bioequivalence assessment for breakout session 4 titled, "Data analysis and model-based bioequivalence (BE)." This session focused on the application of model-based approaches in the generic drug development, with a vision of accelerating regulatory decision making for abbreviated new drug application assessments. The session included both podium presentations and panel discussions with three topics of interest: (i) in vitro study evaluation methods and their clinical relevance, (ii) challenges in model-based BE, (iii) emerging expertise and tools in implementing new BE approaches.
Capacitance–Voltage Measurements of (Bi<sub>1–<i>x</i></sub>Sb<sub><i>x</i></sub>)<sub>2</sub>Te<sub>3</sub> Field Effect Devices (2019)

Capacitance‐voltage ( C – V ) traces in n‐type‐(Bi 1‐ x Sb x ) 2 Te 3 /oxide/metal capacitor structures using an AC capacitance bridge are investigated. By tuning the top gate voltage ( V tg ) from positive to negative values, the system at the interface is tuned from accumulation, via depletion into inversion. The results show the typical low‐frequency and high frequency C – V traces, depending on measuring frequency, temperature, and illumination intensity and reflecting their sensitive dependence on recombination/generation rates. Superimposed a strong hysteresis under inversion is also observed which is ascribed to the presence of conventional localized surface states (LSS) which coexist with topological surface states (TSS).
Design of a broadband highly dispersive pure silica photonic crystal fiber (2007)

A highly dispersive dual-concentric-core pure silica photonic crystal fiber is designed with a maximum chromatic dispersion value of about -9500 ps/(nm km) around the 1.56 microm wavelength region and a full width at half-maximum (FWHM) of 55 nm. The change in the dispersion-bandwidth product as a function of period is carefully studied by using the plane wave expansion method. The coupled mode theory matches well with the plane wave expansion method that was used to simulate the chromatic dispersion. This kind of a photonic crystal fiber structure is suitable for high-dispersion application in phased array antenna systems based on photonic crystal fiber arrays.
Supplementary Figure 3 from Targeting the Kynurenine Pathway for the Treatment of Cisplatin-Resistant Lung Cancer (2023)

&lt;p&gt;Growth Inhibitory effect of cisplatin.&lt;/p&gt;
Passive Kinematic Synchronization of Dissimilar and Uncoupled Rotating Systems (2015)

Passive kinematic synchronization enables two dynamic physical systems to generate the same motion without any physical interaction or mediating control laws. In this paper, we demonstrate a generalized kinematic matching technique to model and passively synchronize two physically dissimilar and uncoupled rotating systems. The method is demonstrated by matching the motion of systems with different masses and mass distributions. Specifically, we matched the nonlinear motion between three single-link pendulums and the motions of two double-link pendulums. Despite the highly nonlinear dynamics of a double-link pendulum, temporal and spectral analysis results show that the two different and kinematically- matched systems generate nearly identical motion. The method is generalizable and can be used to describe and match the kinematics of any dissimilar open-ended rotating system chain such as rotors, discs, cams, or pendulum type systems. This method has implications for the modeling of physical rotating system dynamics, the study of swinging limbs in humans, animals, and robots, and in limb prosthesis design. We also present a step-by-step method to create a dissimilar but synchronized, rotating system, that is, passively matched to an original system. Further, we present a step-by-step method to kinematically synchronize two already available dissimilar rotating systems.
Nonintrusive gas monitoring in neonatal lungs using diode laser spectroscopy: feasibility study (2011)

A feasibility study on noninvasive, real-time monitoring of gases in lungs of preterm infants is reported, where a laser-spectroscopic technique using diode lasers tuned to oxygen and water vapor absorption lines was employed on realistic tissue phantoms. Our work suggests that the technique could provide a new possibility for surveillance of the lung function of preterm infants, in particular the oxygenation, which is of prime importance in this patient group.
&lt;title&gt;AFM scanning moire method for nanodeformation measurement&lt;/title&gt; (2000)

In this study, the atomic force microscope( AFM) scanning moiré method is developed. The scanning lines in the AFM monitor are used as the reference grating. The reference grating interferes with the specimen grating, and forms a moiré pattern on the monitor. The formation mechanism of AFM moiré, the deformation measurement principle using this method are described in detail. The AFM scanning moiré method is used to measure the residual deformation of mica substrate after being damaged by the YAG laser, and the thermal deformation in a QFP type electronic package. The experiment results verify the feasibility of AFM scanning moire method and show its ability to measure the in-plane deformation in both micro-and nano-scales.
Acute Lymphoblastic Leukemia in Elderly Patients: A Single Institution's Experience (2011)

The outcomes of Korean elderly patients with ALL were poor, and the shorter OS was mainly due to the low CR rate. T-cell lineage and the presence of lymphadenopathy were significant prognostic factors in Korean elderly patients with ALL.
Spectrum of Bacterial Colonization Associated with Urothelial Cells from Patients with Chronic Lower Urinary Tract Symptoms (2013)

Chronic lower urinary tract symptoms (LUTS), such as urgency and incontinence, are common, especially among the elderly, but their etiology is often obscure. Recent studies of acute urinary tract infections implicated invasion by Escherichia coli into the cytoplasm of urothelial cells, with persistence of long-term bacterial reservoirs, but the role of infection in chronic LUTS is unknown. We conducted a large prospective study with eligible patients with LUTS and controls over a 3-year period, comparing routine urine cultures of planktonic bacteria with cultures of shed urothelial cells concentrated in centrifuged urinary sediments. This comparison revealed large numbers of bacteria undetected by routine cultures. Next, we typed the bacterial species cultured from patient and control sediments under both aerobic and anaerobic conditions, and we found that the two groups had complex but significantly distinct profiles of bacteria associated with their shed bladder epithelial cells. Strikingly, E. coli, the organism most responsible for acute urinary tract infections, was not the only or even the main offending pathogen in this more-chronic condition. Antibiotic protection assays with shed patient cells and in vitro infection studies using patient-derived strains in cell culture suggested that LUTS-associated bacteria are within or extremely closely associated with shed epithelial cells, which explains how routine cultures might fail to detect them. These data have strong implications for the need to rethink our common diagnoses and treatments of chronic urinary tract symptoms.
The phosphotriesterase gene<i>opdA</i>in<i>Agrobacterium radiobacter</i>P230 is transposable (2003)

We report a transposase gene (tnpA) upstream of the opdA phosphotriesterase gene of Agrobacterium radiobacter P230, as well as inverted repeats indicative of insertion sequences, flanking the two genes. Both the tnpA gene and the inverted repeats resemble the Tn610 transposon from Mycobacterium fortuitum. Two additional putative open reading frames separate opdA and tnpA with inferred translation products with similarity to two proteins encoded on the Geobacillus stearothermophilus IS5376 transposon. To test the proposition that these genes were contained on a transposon, an artificial composite transposon was constructed. This artificial transposon was then delivered into Escherichia coli DH10beta cells. Transposition was demonstrated by the presence of opdA on the E. coli chromosome and confirmation of insertion by inverse polymerase chain reaction. The data presented suggest a possible role of transposition in the distribution of the opd/opdA genes across a wide range of soil bacteria.
Measurement of mode field profiles and bending and transition losses in curved optical channel waveguides (1997)

Curved, single-mode, silicon oxynitride optical ridge channel waveguides have been characterized by measuring mode field profile alteration, bending loss, and transition loss. The results were compared to theoretical calculations. Near field imaging of the channel mode field profiles showed the effect of bend radius on mode shape. Good agreement was obtained between the measurements and profiles obtained from two-dimensional (2-D) beam propagation method calculations. The exponential dependence of bending loss on bend radius and the variation of transition loss on the lateral offset between channels having different bend radius were successfully modeled by two simple theories.
Artifact for BOLT: A Practical Binary Optimizer for Data Centers and Beyond (2019)

This artifact contains the software required to reproduce the experimental findings of the paper "BOLT: A Practical Binary Optimizer for Data Centers and Beyond", CGO 2019. The open-source workload evaluated on this paper is clang 7 and gcc 8.2. Our goal is to demonstrate that building clang/gcc with all optimizations, including LTO and PGO, still leaves opportunities for a post-link optimizer such as BOLT to do a better job at basic block placement and function reordering, significantly improving workload performance. The paper advocates for a two-step profiling pipeline (PGO and BOLT) evaluated on a data-center environment, showing that doing a single pass of profile collection is not enough to leverage the full potential of profile-guide optimizations. In this two-step approach, PGO or AutoFDO can be used to feed the compiler with profile information, which is an important enabler of better inlining decisions, while a second pass is used to collect profile for a post-link optimizer such as BOLT, enabling us to improve basic block order and function order in the final binary and further increase performance.
The Role of Serum Carcinoembryonic Antigen (CEA) in the Management of Patients with Colorectal Carcinoma: The Experience of the Istituto Tumori of Milan (1992)

CEA determination has attained an important role in the clinical management of patients with tumors of the colorectal tract. In this paper the experience of the Istituto Tumori of Milan is reviewed and the results are discussed. Three hundred and thirty-six patients were followed after curative resection of colorectal carcinoma. The follow-up period was 15 years, from January 1975 to December 1990 (global follow-up 1358 years). In the course of follow-up 136 patients developed recurrent disease. The number of CEA determinations for each patient ranged from 1 to 37 (mean 8, total 3330). CEA levels of presurgical patients were related to the clinical stage. Among patients who developed recurrences 61% showed an increase in CEA serum levels. In 200 patients with a negative follow-up we observed only 15 cases of false-positive results.