gebhart/patrepeval huggingface dataset:
Parkinson’s Disease Classification using Pitch Synchronous Speech Segments and Fine Gaussian Kernels based SVM (2020)

Researchers have been using signal processing based methods to assess speech from Parkinson's disease (PD) patients and identify the contrasting features in comparison to speech from healthy controls (HC). The methodologies follow conventional approach of segmenting speech over a fixed window (≈25ms to 30ms) followed by feature extraction and classification. The proposed methodology uses MFCCs extracted from pitch synchronous and fixed window (25ms) based speech segments for classification using fine Gaussian support vector machines (SVM). Three word utterances with three different vowel sounds are used for this analysis. Clustering experiments are aimed at identifying two clusters and class labels (PD/HC) are assigned based on number of participants from the respective class in the cluster. The features are divided into 9 groups based on the vowel content to evaluate the effect of different vowel sounds. Principal component analysis (PCA) is used for dimensionality reduction along with a 10-fold cross-validation. From the results, we observed that pitch synchronous segmentation yields better classification performance compared to fixed window based segmentation. The results of this analysis support our hypothesis that pitch synchronous segmentation is better suited for PD classification using connected speech.Clinical Relevance- The automatic speech analysis framework used in this analysis establishes the greater efficiency of pitch synchronous segmentation over the traditional methods.
Synthesis and Characterization of Polybenzoxazinone and its Prepolymer Using Gas Separation (2013)

Polybenz‐3,1‐oxazinone‐4 (PBOZ) films are prepared via the thermal rearrangement of poly[(methylene‐ bis ‐anthranilamide) 4,4′‐diphenyloxidicarboxylic acid] (PAA) films by heating to 300 °C. PAA is synthesized by low‐temperature polycondensation. The PBOZ film exhibits excellent mechanical properties and a high glass‐transition temperature. Conversion of PAA to PBOZ leads to an increase in the fractional free volume as a result of thermal dehydration and cyclization during membrane formation and due to the removal of residual solvent. The excess free volume in the PBOZ film is approximately 3–4% of the total volume. The gas permeability and selectivity of the PBOZ film is higher than that of the PAA film. The thermal rearrangement of polymers is recognized as a suitable method to improve separation efficiency. image
Insulin Resistance in HIV Protease Inhibitor–Associated Diabetes (1999)

The pathogenesis of HIV PI-associated diabetes involves peripheral insulin resistance with insulin deficiency relative to hyperglucagonemia and a high BMI. Pancreatic beta-cell function was not impaired by indinavir. HIV PI-associated diabetes mirrors that of non-insulin-dependent diabetes mellitus and impaired insulin action in the periphery.
The improbable targeted therapy: KRAS as an emerging target in non-small cell lung cancer (NSCLC) (2021)

KRAS is a frequent oncogenic driver in solid tumors, including non-small cell lung cancer (NSCLC). It was previously thought to be an "undruggable" target due to the lack of deep binding pockets for specific small-molecule inhibitors. A better understanding of the mechanisms that drive KRAS transformation, improved KRAS-targeted drugs, and immunological approaches that aim at yielding immune responses against KRAS neoantigens have sparked a race for approved therapies. Few treatments are available for KRAS mutant NSCLC patients, and several approaches are being tested in clinicals trials to fill this void. Here, we review promising therapeutics tested for KRAS mutant NSCLC.
Numerical Simulation of Wetting-Induced Settlement of Embankments (2017)

In this paper, the Barcelona basic model (BBM) was implemented in a finite difference-based computer program to simulate the behavior of unsaturated soils subjected to wetting. The BBM implementation was verified using analytical solutions, and the verified model was used to simulate the wetting-induced response of a compacted fill embankment subjected to complete saturation as the worst-case scenario for design. Results showed that considerable amount of total and differential settlements could develop at the top surface of the embankment. Additionally, upper sections of the embankment had a tendency to heave, whereas lower sections under larger confining stresses could collapse due to wetting. Results of a subsequent parametric study indicated that initial moisture content, embankment height, and slope angle have significant influences on the wetting-induced deformations and stability of unsaturated embankments.
VLSI design of a high speed turbo decoder for 3rd generation satellite communication (2003)

In the present period in which 3rd generation systems, including their satellite component, are specified and realized, one important issue is to design a powerful channel coding scheme in order to ensure the good propagation of different types of information streams (voice, data) through the mobile satellite channel. In this field and in many other applications, a new class of concatenated codes, called turbo codes, have been introduced. The turbo coding scheme is able to achieve performance close to the Shannon bound, but at the cost of a large transmission delay and decoder complexity. In this paper, we propose the VLSI design of a turbo decoder for high performance in terms of throughput and low latency time compliant with Third Generation Partnership Project (3GPP) specification. A 100 Mbit/s throughput has been demonstrated for an overall complexity of about 112 kgates plus 35 kbits dual port RAM and an operating clock frequency of 100 MHz.
Silia<i>Cat</i> Diphenylphosphine Palladium(II) Catalyzed Borylation of Aryl Halides (2014)

Abstract We investigate the heterogeneously catalyzed direct synthesis of boronic acid pinacol esters using a wide range of aryl chlorides, bromides, and iodides, and bis(pinacolato)diboron as the borylating agent over the sol–gel entrapped Silia Cat diphenylphosphine palladium(II) catalyst. Optimization of the reaction conditions, scale‐up of the optimized process, and analysis of palladium leaching enabled us to establish a new selective route for direct access to a diverse set of boronic acid pinacol esters.
Intra-Articular Delivery of an Indoleamine 2,3-Dioxygenase Galectin-3 Fusion Protein for Osteoarthritis Treatment in Male Lewis Rats (2023)

<b>Objective</b> : Controlling joint inflammation can improve osteoarthritis (OA) symptoms; however, current treatments often fail to provide long-term effects. We have developed an indoleamine 2,3-dioxygenase and galectin-3 fusion protein (IDO-Gal3). IDO converts tryptophan to kynurenines, directing the local environment toward an anti-inflammatory state; Gal3 binds carbohydrates and extends IDO's joint residence time. In this study, we evaluated IDO-Gal3's ability to alter OA-associated inflammation and pain-related behaviors in a rat model of established knee OA. <b>Methods</b> : Joint residence was first evaluated with an analog Gal3 fusion protein (NanoLuc™ and Gal3, NL-Gal3) that produces luminescence from furimazine. OA was induced in male Lewis rats via a medial collateral ligament and medial meniscus transection (MCLT+MMT). At 8 weeks, NL or NL-Gal3 were injected intra-articularly (n=8 per group), and bioluminescence was tracked for 4 weeks. Next, IDO-Gal3's ability to modulate OA pain and inflammation was assessed. Again, OA was induced via MCLT+MMT in male Lewis rats, with IDO-Gal3 or saline injected into OA-affected knees at 8 weeks post-surgery (n=7 per group). Gait and tactile sensitivity were then assessed weekly. At 12 weeks, intra-articular levels of IL6, CCL2, and CTXII were assessed. <b>Results</b> : The Gal3 fusion increased joint residence in OA and contralateral knees (p<0.0001). In OA-affected animals, IDO-Gal3 improved tactile sensitivity (p=0.002), increased walking velocities (p≤0.033), and improved vertical ground reaction forces (p≤0.04). Finally, IDO-Gal3 decreased intra-articular IL6 levels within the OA-affected joint (p=0.0025). <b>Conclusion</b> : Intra-articular IDO-Gal3 delivery provided long-term modulation of joint inflammation and pain-related behaviors in rats with established OA.
Relative concentration of 13,14-dihydro-15 keto-prostaglandin F-2α in blood and milk of buffaloes during the oestrous cycle and early pregnancy (1983)

Summary. Concentrations of PGFM in blood and milk of 28 Murrah buffaloes increased significantly (P &amp;lt; 0·001) in non-pregnant animals before oestrus but not in pregnant animals. The PGFM level in milk was similar to that in blood plasma and was positively correlated in non-pregnant (r = 0·981) and pregnant (r = 0·521) animals. Mean blood plasma PGFM concentration was not significantly (P &amp;lt; 0·05) different from that of milk.
Aciculatin Induces p53-Dependent Apoptosis via MDM2 Depletion in Human Cancer Cells In Vitro and In Vivo (2012)

Aciculatin, a natural compound extracted from the medicinal herb Chrysopogon aciculatus, shows potent anti-cancer potency. This study is the first to prove that aciculatin induces cell death in human cancer cells and HCT116 mouse xenografts due to G1 arrest and subsequent apoptosis. The primary reason for cell cycle arrest and cell death was p53 accumulation followed by increased p21 level, dephosphorylation of Rb protein, PUMA expression, and induction of apoptotic signals such as cleavage of caspase-9, caspase-3, and PARP. We demonstrated that p53 allele-null (-/-) (p53-KO) HCT116 cells were more resistant to aciculatin than cells with wild-type p53 (+/+). The same result was achieved by knocking down p53 with siRNA in p53 wild-type cells, indicating that p53 plays a crucial role in aciculatin-induced apoptosis. Although DNA damage is the most common event leading to p53 activation, we found only weak evidence of DNA damage after aciculatin treatment. Interestingly, the aciculatin-induced downregulation of MDM2, an important negative regulator of p53, contributed to p53 accumulation. The anti-cancer activity and importance of p53 after aciculatin treatment were also confirmed in the HCT116 xenograft models. Collectively, these results indicate that aciculatin treatment induces cell cycle arrest and apoptosis via inhibition of MDM2 expression, thereby inducing p53 accumulation without significant DNA damage and genome toxicity.
Aluminophosphate glasses and quasi-amorphous nitrides - a step in the quest for photonic materials (2004)

Summary form only given. We present a review of the research carried out during the past six months by groups from Romania, Victoria University of Wellington, New Zealand, and Universite de Provence, Marseille, France, with the aim to fabricate photonic materials within the framework of the COST ACTION P11. Novel aluminophosphate glasses doped with semiconductors (CdSSe) have been produced, whose transmission in the visible and Raman spectra have been investigated. We have noticed that transmission edge and the spectra shape depend on the crystallites' dimensions. The fluorescence is relatively narrow (0.12-0.15 eV) suggesting reasonably well-ordered crystallites with reasonably uniform diameters. Another attempt of the groups to find a way of producing quasi-periodic, at this stage, features, in amorphous materials, consists of annealing studies on amorphous GaN thin films (150 nm) on silicon. The annealing processes have been carried out using the hot stage of an electronic microscope (SEM), so that real time observation has been possible. Following the annealing, the GaN films have developed hemispherical structures uniformly distributed over the entire surface of the sample. Apparently, those structures are denser than the surrounding film, and EDX analysis shows that they conserved the initial composition of the film. At the necked eye the colour of the sample changed from blue to yellow.
The role of microsphere fabrication methods on the stability and release kinetics of ovalbumin encapsulated in polyanhydride microspheres (2006)

The effect of microsphere fabrication methods on the stability and release kinetics of ovalbumin encapsulated in polyanhydride microspheres was investigated. The polyanhydrides used were poly(sebacic anhydride) (poly(SA)) and a 20:80 random copolymer of poly[1,6-bis(p-carboxyphenoxy)hexane] (poly(CPH)) and poly(SA). Microspheres were fabricated using three double emulsion methods (water/oil/water, water/oil/oil and solid/oil/oil) and cryogenic atomization. The encapsulation efficiency was highest for cryogenic atomization and lowest when the w/o/w technique was used. Microspheres fabricated by the s/o/o method had the largest initial burst of released protein. All the methods resulted in zero-order release of the protein after the burst. The release of ovalbumin from poly(SA) and 20:80 (CPH:SA) microspheres lasted approximately 3 and approximately 6 weeks, respectively. For all fabrication methods the primary structure of released ovalbumin was conserved as determined by gel electrophoresis. The secondary structure of ovalbumin encapsulated in 20:80 (CPH:SA) w/o/w microspheres was not conserved.
Numerical and Experimental Investigation on Thermal Characteristics of Deformable Thin Film Mirrors Package and Its Performance Optimization (2008)

This paper presents the thermal characteristics of a microelectro-mechanical deformable thin film mirrors package for the optical modulators used in mobile equipment such as cellphones, lab tops and PDA. One critical factor which affects the performance of the package is the ambient temperature change. To reduce the effect of the ambient temperature change, the temperature control system by a micro heater and a temperature feedback circuit was developed. The thermal characteristics histories were numerically modeled, the results of which were validated by the experimental data. The magnitude of the fluctuation was reduced within 1°C under the controlled system. In addition, required time to reach the steady state temperature was reduced by using the proposed control system.
Objective Assessment of the Quality of Vision Before and After Repositioning of a Dislocated Iris-fixated Aphakic Anterior Chamber Lens (2007)

These are the first diagnostic images of this kind in a highly aberrated eye with iris-fixated anterior chamber lens dislocation. The images documented the optical effect and visual consequences of IOL decentration and subsequent recentration.
Endothelial cell interactions with hepatic progenitor cells affect proliferation and differentiation (2007)

Walkup, Maggie H. MD; Wright, Natasha BS; Samuelson, Lisa BA; Gerber, David A. MD, FACS Author Information
Construction of phosphatidylethanolamine-less strain ofSaccharomyces cerevisiae. Effect on amino acid transport (2001)

A triple yeast mutant was constructed which lacks BST1, the gene for sphingosine lyase, besides the phosphatidylserine decarboxylases PSD1 and PSD2. In this yeast mutant, which can only be grown in the presence of exogenous ethanolamine, phosphatidylethanolamine can be depleted to very low levels. Under those conditions, respiration as well as glucose and 3-O-methylglucose uptake proceed unaffected. Plasma membrane ATPase is as active in these cells as that of control cells grown in the presence of ethanolamine. Drastically decreased, however, are H+/amino acid symporters. The activities of arginine (Can1p), proline (Put4p) and general amino acid permease (Gap1p) are decreased more than 20-fold. Amino acid transport in yeast is dependent on coupling to the proton motive force. It can be envisaged that phosphatidylethanolamine might play a role in this process or in the early steps of the secretion pathway common for all amino acid permeases or, eventually, it could affect the transport proteins directly at the plasma membrane Transformation of the triple mutant with a CEN plasmid harbouring BST1 wild-type gene totally reversed its phenotype to that observed in the double mutant.
Iperkalemia cronica nei pazienti cardio – renali: q &amp; a per il cardionefrologo pratico (2019)

Abstract non disponibile (Cardionephrology)
Absorption of Zinc from Dietary Casein Phosphopeptide Complex with Zinc in Rats Given a Soybean Protein-Based Diet. (2002)

The absorption of zinc (Zn) in the form of casein phosphopeptide (CPP) complex was compared with that of its chloride form in rats given a soybean protein-based diet. We prepared 67Zn complex with CPP (67Zn-CPP). Male rats were given a diet containing ZnCl2 in the preliminary period. After overnight food deprivation, they were fed a test meal labeled 67Zn-CPP or 67ZnCl2 (4 g Zn-free diet + 0.12 mg 67Zn) with 0.5 mg Dysprosium (Dy) as a fecal marker. Feces were collected for 5 d and analyzed for 67Zn isotopic enrichment and Dy concentration with an inductively coupled plasma mass spectrometer. Fecal Dy excretion closely paralleled that of 67Zn, and more than 89% of the administered Dy was recovered in the feces collected for 5 d. Moreover, the Zn source did not affect the excretion pattern of 67Zn. Since Dy and 67Zn were almost excreted within 3 d after the administration, the apparent absorption of 67Zn was calculated from the pooled data for 3 d. The source of Zn did not affect the apparent absorption of 67Zn. These results suggested that dietary Zn in the form of CPP complex did not show higher absorbability in rats.
Bit-Rate Tunable Clock Recovery of NRZ-DPSK Signal Based on Delay-Asymmetric Nonlinear Loop Mirror and Stimulated Brillouin Scattering Loop (2010)

We demonstrate bit-rate tunable clock recovery of NRZ-DPSK signal. The signal is converted to RZ-OOK by demodulation and by phase erasure. Recovered clock signals from 4 to 13 GHz are obtained through a SBS loop.
Thermal Development Test of the NEXT PM1 Ion Engine (2007)

NASA's Evolutionary Xenon Thruster (NEXT) is a next-generation high-power ion propulsion system under development by NASA as a part of the In-Space Propulsion Technology Program. NEXT is designed for use on robotic exploration missions of the solar system using solar electric power. Potential mission destinations that could benefit from a NEXT Solar Electric Propulsion (SEP) system include inner planets, small bodies, and outer planets and their moons. This range of robotic exploration missions generally calls for ion propulsion systems with deep throttling capability and system input power ranging from 0.6 to 25 kW, as referenced to solar array output at 1 Astronomical Unit (AU). Thermal development testing of the NEXT prototype model 1 (PM1) was conducted at JPL to assist in developing and validating a thruster thermal model and assessing the thermal design margins. NEXT PM1 performance prior to, during and subsequent to thermal testing are presented. Test results are compared to the predicted hot and cold environments expected missions and the functionality of the thruster for these missions is discussed.
Identification and Evaluation of Apoptosis-Inducing Activity of Ipomone from <i>Ipomoea nil</i>: A Novel, Unusual Bicyclo-[3.2.1] Octanone Containing Gibberic Acid Diterpenoid (2021)

Ipomone (<b>1</b>), a novel diterpenoid along with seven known compounds (<b>2</b>-<b>8</b>), was isolated for the first time from the acidified hydroalcoholic extract of <i>Ipomoea nil</i> seeds. The structures of the isolated compounds were elucidated via comprehensive NMR spectroscopic data. The absolute configuration of <b>1</b> was ascertained through NOESY, NMR, and ECD analyses. Compound <b>1</b> was found to contain an unusual bicyclo-[3.2.1] octanone, which appeared first time in any natural product that might be an artifact resulting from the acid-catalyzed 1,2 alkyl shift/rearrangement. The novel compound was screened for cytotoxic activity against a panel of 12 human cancer cell lines and exhibited weak cytotoxicity with IC<sub>50</sub> values in the range of 34-86 μM (except for HEK-293 cells). Microscopic studies revealed that compound <b>1</b> induced apoptosis and autophagy in A549 cells. To further explore the signaling pathway involved, immunoblot analysis was performed that confirmed inhibition of apoptotic proteins PARP-1 and caspase-3 expression and upregulation of LC3B expression by compound <b>1</b>. The compound was further subjected to molecular docking studies to evaluate its binding affinity with p110α, PARP-1, and caspase-3 proteins.
Enantioselective ring construction with control of side-chain stereochemistry. Synthesis of (+)-isoneonepetalactone (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnantioselective ring construction with control of side-chain stereochemistry. Synthesis of (+)-isoneonepetalactoneDouglass F. Taber, John C. Amedio Jr., and Krishna RamanCite this: J. Org. Chem. 1988, 53, 13, 2984–2990Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00248a016https://doi.org/10.1021/jo00248a016research-articleACS PublicationsRequest reuse permissionsArticle Views982Altmetric-Citations71LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Mixture design using derivative‐free optimization in the space of individual component properties (2015)

In this work, we propose a new methodology for mixture design. By projecting the problem on the space of individual component properties, the methodology exploits a natural problem decomposition and capitalizes on fast methods for pure compound design and mixture fraction design. We demonstrate the proposed methodology through application to two illustrative examples and then to two problems from the mixture design literature concerning the purification of ibuprofen. In all cases, the proposed approach finds optimal solutions while exploring a small number of feasible molecular structures. © 2016 American Institute of Chemical Engineers AIChE J , 62: 1514–1530, 2016