gebhart/patrepeval huggingface dataset:
Supplementary Table 3 from Immune Profiling of Combined Hepatocellular- Cholangiocarcinoma Reveals Distinct Subtypes and Activation of Gene Signatures Predictive of Response to Immunotherapy (2023)

&lt;p&gt;Supplementary Table 3: Difference in gene expression between IH1 and IH2 subtypes IH: Immune - High&lt;/p&gt;
Drop Deformation and Breakup Mechanisms in Viscoelastic Model Fluid Systems and Polymer Blends (2002)

Abstract This paper reviews the dispersion mechanisms in viscoelastic systems under relatively high shear rate conditions. In particular, two non‐Newtonian deformation and breakup mechanisms were revealed by flow visualization in a transparent Couette shearing setup. The first one is the dispersed droplet elongation perpendicular to the flow direction. This was observed only for viscoelastic drops and had been associated to normal force buildup in the droplet. The second deformation/breakup mechanism was observed in very high viscosity ratio polymer systems. It consists in erosion at the drop surface. Clouds of very small ribbons and sheets were developed around the drop then stretched and finally broken into very small droplets, rapidly distributed in the matrix.
Tri(indolyl)phosphine oxides: Attempted formation of lower rim-capped cone conformers of calix[3]indoles (1996)

3-(p-Chlorophenyl)-4,6-dimethoxyindole (1a>), 3(p-bromophenyl)-4,6-dimethoxyindole (1b), 5-benzyloxyindole (1c), and indole (1d) yield the corresponding tri(indolyl)phosphine oxides (2a-d), on sequential treatment with n-butyllithium and phosphoryl chloride. The related phosphines, arsines, and stibines were not isolated. The stibine from indole (1a) is implicated as a reactive intermediate in the formation of the calix[3]indole (5), following its interaction with formaldehyde. © 1996 John Wiley & Sons, Inc.
Phase identification and control of thin films deposited by co-evaporation of elemental Cu, Zn, Sn, and Se (2012)

Kesterite thin films [(i.e., Cu2ZnSn(S,Se)4 and related alloys] have been the subject of recent interest for use as an absorber layer for thin film photovoltaics due to their high absorption coefficient (&amp;gt;104 cm−1), their similarity to successful chalcopyrites (like CuInxGa1−xSe2) in structure, and their earth-abundance. The process window for growing a single-phase kesterite film is narrow. In this work, we have documented, for our 9.15%-efficient kesterite co-evaporation process, (1) how appearance of certain undesirable phases are controlled via choice of processing conditions, (2) several techniques for identification of phases in these films with resolution adequate to discern changes that are important to device performance, and (3) reference measurements for those performing such phase identification. Data from x-ray diffraction, x-ray fluorescence, Raman scattering, scanning electron microscopy, energy dispersive spectroscopy, and current-voltage characterization are presented.
Radical Entry Mechanisms in Alkali-Soluble-Resin-Stabilized Latexes (2009)

Alkali-soluble resins (ASRs) are random copolymers that contain both hydrophobic groups and a large number of carboxylic acid groups, which are widely used as the sole stabilizers in the production of waterborne dispersed polymers because they remarkably improve the end-use properties of the latexes. However, they reduce the radical entry rate. In this work, the mechanisms for radical entry in ASR-stabilized systems have been investigated. It has been found that the mechanism responsible for the reduction of the rate of radical entry depends on the type of ASR used (prone or not prone to suffer hydrogen abstraction), the type of radical produced from the initiator (charged or uncharged, oxygen centered or carbon centered), the phase where the radicals are produced (aqueous or oil phase) and the type of monomer (hydrophobic like styrene or more hydrophilic like methyl methacrylate).
Rücktitelbild: Strongly Fluorescent, Switchable Perylene Bis(diimide) Host–Guest Complexes with Cucurbit[8]uril In Water (Angew. Chem. 31/2012) (2012)

Die supramolekulare Komplexierung von Perylenbis(diimid)-Farbstoffen mit dem makrocyclischen Wirt Cucurbit[8]uril verhindert die Aggregation der Farbstoffmoleküle und ermöglicht ihre Anwendung als photochemisch stabile Fluorophore in Wasser. In der Zuschrift auf S. 7859 ff. zeigen O. A. Scherman et al., dass die Fluoreszenz dieser Komplexe elektrochemisch reversibel an- und ausgeschaltet werden kann. Außerdem werden in Wasser höhere nichtkovalent verknüpfte Architekturen erhalten.
The motile beta/IC1 subunit of sea urchin sperm outer arm dynein does not form a rigor bond. (1992)

We used in vitro translocation and cosedimentation assays to study the microtubule binding properties of sea urchin sperm outer arm dynein and its beta/IC1 subunit. Microtubules glided on glass-absorbed sea urchin dynein for a period of time directly proportional to the initial MgATP2- concentration and then detached when 70-95% of the MgATP2- was hydrolyzed. Detachment resulted from MgATP2- depletion, because (a) perfusion with fresh buffer containing MgATP2- reconstituted binding and gliding, (b) microtubules glided many minutes with an ATP-regenerating system at ATP concentrations which alone supported gliding for only 1-2 min, and (c) microtubules detached upon total hydrolysis of ATP by an ATP-removal system. The products of ATP hydrolysis antagonized binding and gliding; as little as a threefold excess of ADP/Pi over ATP resulted in complete loss of microtubule binding and translocation by the beta/IC1 subunit. In contrast to the situation with sea urchin dynein, microtubules ceased gliding but remained bound to glass-absorbed Tetrahymena outer arm dynein when MgATP2- was exhausted. Cosedimentation assays showed that Tetrahymena outer arm dynein sedimented with microtubules in an ATP-sensitive manner, as previously reported (Porter, M.E., and K. A. Johnson. J. Biol. Chem. 258: 6575-6581). However, the beta/IC1 subunit of sea urchin dynein did not cosediment with microtubules in the absence of ATP. Thus, this subunit, while capable of generating motility, lacks both structural and rigor-type microtubule binding.
Plasmonic effects of thermally evaporated aluminum nanoparticles on the electroluminescence of organic light-emitting diode subject to exciplex (2019)

We report the investigation of the influence of plasmonic aluminum nanoparticles (Al-NPs), randomly dispersed into the blue organic light-emitting diode (OLED) subject to exciplex emission. The results show that, on the one hand, for the device without Al-NPs, two emission peaks at 437 and 470 nm attributed to excitons of the emitting layer (EML) and exciplexes formed at the hole transport layer/EML interface, respectively. On the other hand, for the device with Al-NPs, the exciplex emission has almost disappeared due to the localized surface plasmonic resonance effect. Moreover, the effective coupling between excitons and localized surface plamson of Al-NPs improved the radiative emission rate of the EML. We observed an enhancement of 50% of the luminous efficiency of the plasmonic-OLED device. In addition to that, the exciton lifetime of the reference sample without metallic nanoparticles is found 1.6 ns, whereas that of the plasmonic sample is prominently decreased to 0.7 ns, emphasizing the plasmonic effect of Al-NPs on the emission of our blue-OLEDs.
Asymptotic Analysis of the Torsional Vibrations in Reciprocating Machinery (1995)

Abstract A class of two degree of freedom reciprocating machines is analysed and simple asymptotic expressions for both the steady state and transient vibration levels are obtained. The results are compared with those of a standard numerical modeling package, and are found to be in good agreement for parameter values typical of real machines. This happens because real machines are designed so that the vibration levels are small, thereby satisfying the conditions for the validity of the approximation.
OneProvenance: Efficient Extraction of Dynamic Coarse-Grained Provenance from Database Logs [Technical Report] (2022)

Provenance encodes information that connects datasets, their generation workflows, and associated metadata (e.g., who or when executed a query). As such, it is instrumental for a wide range of critical governance applications (e.g., observability and auditing). Unfortunately, in the context of database systems, extracting coarse-grained provenance is a long-standing problem due to the complexity and sheer volume of database workflows. Provenance extraction from query event logs has been recently proposed as favorable because, in principle, can result in meaningful provenance graphs for provenance applications. Current approaches, however, (a) add substantial overhead to the database and provenance extraction workflows and (b)~extract provenance that is noisy, omits query execution dependencies, and is not rich enough for upstream applications. To address these problems, we introduce OneProvenance: an efficient provenance extraction system from query event logs. OneProvenance addresses the unique challenges of log-based extraction by (a)~identifying query execution dependencies through efficient log analysis, (b) extracting provenance through novel event transformations that account for query dependencies, and (c)~introducing effective filtering optimizations. Our thorough experimental analysis shows that OneProvenance can improve extraction by up to ~18X compared to state-of-the-art baselines; our optimizations reduce the extraction noise and optimize performance even further. OneProvenance is deployed at scale by Microsoft Purview and actively supports customer provenance extraction needs (https://bit.ly/3N2JVGF).
Annealing-tuned Hall coefficient in single crystals of the YbNi$_2$B$_2$C heavy fermion (2004)

We present temperature-dependent magneto-transport measurements on as-grown and annealed YbNi$_2$B$_2$C single crystals. Annealing causes drastic changes in the Hall coefficient, $R_H(T)$. Whereas for as-grown samples the Hall coefficient is negative between room temperature and 2 K, with a pronounced {\it minimum} at $\approx 22$ K, for the samples annealed at $950^\circ$ C for 150 hours, $R_H(T)$ changes its sign twice in the same temperature range: from negative to positive on cooling below $\sim 100$ K and back to negative below $\sim 10$ K, and has a clear {\it maximum} at $\approx 45$ K. Intermediate temperature dependencies can be achieved by reducing the annealing time. These findings are discussed within the framework of an annealing dependence of the skew scattering in conjunction with the recent structural, thermodynamic and transport studies of the effects of annealing in YbNi$_2$B$_2$C.
EFFICIENT CHEMO-ENZYMATIC SYNTHESES OF PHARMACEUTICALLY USEFUL UNNATURAL 2′-DEOXYNUCLEOSIDES (2005)

Our chemo-enzymatic method was successfully applied to the synthesis of 2-chloro-2'-deoxyadenosine (CdA, cladribine) in two ways: 1) direct conversion of chemically synthesized 2-deoxy-alpha-D-ribose 1-phosphate (dRP) to CdA; 2) a two-step route via 9-(2-deoxy-beta-D-ribos-1-yl)-2, 6-dichloropurine (Cl2Pu-dR, 5).
Prostaglandins E2 and E1 inhibit cytokine-induced metalloprotease expression in human synovial fibroblasts. Mediation by cyclic-AMP signalling pathway. (1994)

We conclude that IL-1 beta stimulates MMP synthesis by activating PKC but not PKA, and that the synthesis of collagenase and stromelysin is discoordinate on a temporal and quantitative basis. PGs inhibit rhIL-1 beta-induced MMP expression and synthesis by virtue of their ability to increase cAMP intracellular levels and subsequent activation of signal transduction mechanisms involving PKA. Homeostasis may be maintained in acute episodes of joint inflammation through feedback processes involving locally produced eicosanoids.
Carboplatin in metastatic castrate resistant prostate cancer: A retrospective study of heavily pretreated patients (COMPACT). (2023)

158 Background: Despite a lack of up-to-date clinical trial data, many clinicians advocate the use of Carboplatin monotherapy to treat patients with advanced Castrate Resistant Prostate Cancer (CRPC) who have exhausted multiple other treatment options. The aim of this study was to determine the overall survival (OS) and response rate in patients with advanced CRPC treated with Carboplatin monotherapy after progressing on other chemotherapy agents. Methods: Retrospective multicentre study of the use of Carboplatin in advanced CRPC patients in Australia. Demographic data, PSA response rates, survival data and Carboplatin treatment protocols, such as dose and duration, were collected. Exploratory analyses on potential prognostic parameters were performed. Results: 51 patients received Carboplatin: median age 68 (range 55–86 years). Most patients (78.3%) received Carboplatin AUC 5 at 3-weekly intervals. The median number of cycles of Carboplatin was 3 (range 1-17). Median time on treatment was 63 days (range 1-441). Median overall survival was 29.4 weeks (IQR 11.7 weeks). 6 (11.8%) patients had a PSA response ≥50%. The median time to PSA progression on Carboplatin was 67 days (range 15-418). 16 patients (31%) required a dose delay or reduction and 8 patients (15.6%) ceased Carboplatin secondary to side effects/ toxicity. Conclusions: Our findings demonstrate that in heavily pre-treated CRPC, Carboplatin has a modest benefit in a minority of patients with a low rate of toxicity in the advanced prostate cancer population.
5. Long-term Reliable Prosthetic Hand and Wrist Control Using Regenerative Peripheral Nerve Interfaces (RPNIs) and Implanted Electrodes (2023)

PURPOSE: State-of-the-art prosthetic limbs can actuate multiple grasps and wrist movements, but a lack of reliable and intuitive control leads to user dissatisfaction and device abandonment. Intramuscular electrodes can improve control fidelity. However, amputation limits the number of muscles available to provide control signals for complex prosthetic functions. In clinical trials, the Regenerative Peripheral Nerve Interface (RPNI) has been shown to amplify efferent nerve action potentials in lieu of missing muscles. The purpose of this study was to determine if RPNI signals can be used to achieve reliable prosthetic hand and wrist control in individuals with upper limb amputation. METHODS: RPNIs were created by implanting a severed peripheral nerve into a free muscle graft. Three participants with transradial amputations (P1, P2, and P3) had intramuscular bipolar electrodes surgically implanted into RPNIs on their median and ulnar nerves, and 5-8 residual muscles. The percutaneous electrodes were connected to a real-time computer. RESULTS: To date, signal-to-noise ratios (SNRs) have been measured approximately monthly across 267 days for P1 (12 sessions), 1240 days for P2 (37 sessions), and 335 days for P3 (12 sessions). Thumb flexion evoked the largest amplitude response from the median nerve RPNIs with average (mean±std) SNRs of 160±69.0 (P1), 25.3±8.8 (P2), and 280±35.3 (P3). Small finger flexion or wrist flexion evoked the largest response from the ulnar RPNIs with average SNRs of 35.8±11.0 (P1), 32.7±11.9 (P2), 14.7±2.5 (P3). There have been no significant declines in the SNR of RPNI signals over time (p > 0.05, F-test). Patients used a real-time pattern recognition system to control commercial multi-grip prosthetic hands with electromyography from RPNIs and residual muscles. Consistent with previous work, control parameters did not require re-calibration between experiment sessions. P1 used fist, pinch, and point to complete a multi-grip reach and place task with 89.9% accuracy. P3 used hand open and close along with wrist pronation and supination to complete pouring, jar opening, and object moving of the Southampton Hand Assessment Procedure with a linear index of functionality of 69.7 (best trial, range 0-100). P2 used fist, pinch, point and active wrist rotation to complete a multi-grip coffee making task with a grip selection accuracy of 90%. CONCLUSIONS: RPNIs produced large amplitude motor signals with no signal degradation over time, enabling all three participants to control multiple prosthetic functions accurately and reliably. Clinical translation of this technology will increase prosthetic functionality and reduce device abandonment.
Vertically Oriented Polymer Electrolyte Nanofiber Catalyst Support for Thin Film Proton‐Exchange Membrane Fuel Cell Electrodes (2015)

Abstract Polymer electrolyte fuel cells are highly efficient and offer high power density, but high precious‐metal loading and degradation of carbon‐supported platinum (Pt) catalysts still hinder commercialization. Ionomer binders in conventional electrodes also introduce undesirable, high oxygen‐transport resistance. This paper presents an alternative composite Nafion nanofiber catalyst support electrode, in which the nanofibers provide robust internal proton transport to a conformal Pt catalyst coating without impeding O 2 transport. The high‐surface‐area electrodes are prepared by solution casting ionomer onto a sacrificial template to simultaneously fabricate the nanofibers and the membrane. Thin Pt films are deposited on the nanofibers using either physical vapor deposition or chemical vapor deposition. The electrochemical characterization of the nanofiber electrodes demonstrates the high current density and specific activity of this nanofiber approach relative to prior electrodes fabricated by depositing Pt directly onto other Nafion surfaces.
Technical, Medical and Ethical Challenges in Networks of Smart Active Implants (2019)

Networks of distributed interactive micro-implants could enhance the treatment of otoneurological conditions such as tinnitus or restore impaired complex physiological/ motor functions such as gastrointestinal motility or grasping. For this, an electrical stimulation of neural and muscular tissue is a key prerequisite. Challenges in the development of such interactive micro-implants are the complex human-machine interface, the wireless power supply, and the long-term stability of implants as well as secure and safe signal transmission. This paper addresses all these topics as well as the ethical, legal and social implications of smart implant networks in general. First achievements of the German innovation cluster INTAKT will be presented.
Impaired binding of a DQ2 and DQ8‐binding HSV VP16 peptide to a DQA1*0501/DQB1*0302 <b><i>trans</i></b> class II heterodimer (1999)

DQalpha and DQbeta trans heterodimeric HLA-DQ molecules form in individuals heterozygous for the DQ2 and DQ8 specificities. Unique functions and disease associations have been postulated for such trans-dimers, which may be different from cis-encoded DQ molecules encoded by the corresponding haplotypes. We analyzed the ability of the trans-dimer encoded by HLA-DQA1*0501/DQB1*0302 to bind a peptide antigen which interacts with DQ molecules encoded by both parental haplotypes. Markedly impaired binding was observed, consistent with both the use of different anchor residues and with changes in levels of DQ cis-dimer availability for peptide binding interactions.
Recycling of Spent Catalysts Containing Base Metals (2008)

The sections in this article are Introduction Catalysis is “Green” Context: the Catalyst Industry and Market Base Metal Solid Catalysts Raw Materials Drivers for Recycle Catalyst Product Life Cycles Product Life Cycles Important Factors Legislation Environmental/Ecological/Health Hazards Societal Economic/Commercial SUSCHEM [11] SUSCHEM Catalyst Care Program [12] Catalyst Care Program Conventional Methods for Disposal and Recovery End-of-Life Options End-of-Life Catalysts—Growing Issues with the Current Approach Examples of Metals Recovery Cu, Ni, Co, Zn Fe, Cr Ni/Mo, Co/Mo Reuse in Catalyst Manufacture Future Trends and Challenges Conclusions Acknowledgments
Compounds with myorelaxant activity from the leaves of Mareya micrantha (Benth.) Müll. Arg. (Euphorbiaceae) (2020)

Mareya micrantha (Euphorbiaceae) is an Ivorian medicinal plant widely used in gastrointestinal disorders. So as to understand and identify metabolites possibly implicated in the activity of the plant on intestinal muscles, this study has been undertaken. From the crude ethanolic extract EE of the leaves, hexanic (EH), chloromethylene (EC), ethyl acetatic (EA) and butanolic (EB) sub-extracts were prepared as well as the hydroethanolic residual phase dried (Ar) and their effects on the isolated duodenum of rabbits were determined. If the sub-extracts EH, EA and EB, but also Ar, confirmed the myostimulant activity of the crude extract EE, this was not the case of EC which showed myorelaxant activity. This sub-extract, subjected to purification, led to the isolation of three major triterpenoids type 29-norcucurbitacin (1-3) whose structures were confirmed using the combined analyses of their spectroscopic data (UV, MS, 1D NMR and 2D). All these molecules have shown myorelaxant activity, the most significant one being 2 with an IC50 value of 36.9 µM. These molecules would act by blocking both intracellular and extracellular calcium.
Estimating crop yields with deep learning and remotely sensed data (2015)

This paper describes Illinois corn yield estimation using deep learning and another machine learning, SVR. Deep learning is a technique that has been attracting attention in recent years of machine learning, it is possible to implement using the Caffe. High accuracy estimation of crop yield is very important from the viewpoint of food security. However, since every country prepare data inhomogeneously, the implementation of the crop model in all regions is difficult. Deep learning is possible to extract important features for estimating the object from the input data, so it can be expected to reduce dependency of input data. The network model of two InnerProductLayer was the best algorithm in this study, achieving RMSE of 6.298 (standard value). This study highlights the advantages of deep learning for agricultural yield estimating.
Valence orbital momentum distributions in <i>s</i>-triazine (1985)

Valence orbital momentum distributions, ρ(q), are obtained for s-triazine, C3H3N3, from (e,2e) spectroscopy and split valence SCFMO calculations. The separation energy spectrum simulated using the calculated ρ(q) and ionization energies from Green’s function calculations is in good agreement with experiment from 9–20 eV, but at higher energy the simulated spectrum has higher intensity than experiment, indicating that the Green’s function calculation underestimates the complexity of the inner valence region. The calculated momentum distributions have their maxima at higher values than observed experimentally for the outermost valence orbitals, but the difference in momentum distributions between the antisymmetric 4e′ N2p lone pair orbital of s-triazine and the N2p lone pair orbital of ammonia is reproduced well by the calculations. Similarly, calculated and experimental differences of Fourier transformed ρ(q) for the 4e′ and 3a′1 N2p lone pair orbitals of triazine are in agreement and can be interpreted using plots of 4e′ and 3a1 orbital averages and differences from the SCFMO calculations. The Fourier transformed momentum distribution of the 4e′ orbital clearly shows the presence of both nearest-neighbor C and second-nearest-neighbor N interactions.