gebhart/patrepeval huggingface dataset:
Learn to chill (2021)

Centralized chiller plants with multiple chillers are typically over-provisioned. Therefore, intelligent scheduling is required for the supply (operating chillers) to efficiently meet the demand (actual cooling load of buildings). Traditional cooling-load based control (CLC) may result in poor part-loaded efficiency. Recent data-driven approaches to chiller control either unrealistically assume perfect knowledge of individual chiller power at various leaving chilled water temperatures (LWTs) or control all chillers with same LWT.
Review article: novel methods for the treatment of non-alcoholic steatohepatitis - targeting the gut immune system to decrease the systemic inflammatory response without immune suppression (2016)

Oral immunotherapy may provide a novel platform for the treatment of NASH.
Impact of the acute local inhibition of soluble epoxide hydrolase on diabetic skin microcirculatory dysfunction (2019)

The impact of the local inhibition of soluble epoxide hydrolase, which metabolizes vasodilator and anti-inflammatory epoxyeicosanoids, on diabetic skin microvascular dysfunction was assessed. In diabetic db/db mice, basal skin blood flow assessed using laser Doppler imaging was similar to that of control mice, but thermal hyperemia was markedly reduced. At 2 h after the topical administration of an aqueous gel containing the soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid (t-AUCB: 400 mg/L), the peak concentration of t-AUCB was detected in the skin of diabetic mice, which quickly decreased thereafter. In parallel, 2 h after application of t-AUCB treatment, thermal hyperemia was increased compared to the control gel. Quantification of t-AUCB in plasma of treated animals showed no or low systemic diffusion. Furthermore, haematoxylin and eosin histological staining of skin biopsies showed that skin integrity was preserved in t-AUCB-treated mice. Finally, for pig ear skin, a surrogate for human skin, using Franz diffusion cells, we observed a continuous diffusion of t-AUCB from 2 h after application to beyond 24 h. A single topical administration of a soluble epoxide hydrolase inhibitor improves microcirculatory function in the skin of db/db mice and might represent a new therapeutic approach for preventing the development of skin complications in diabetic patients.
Control of Interface Shape by Non-Axisymmetric Solution Convection in Top-Seeded Solution Growth of SiC Crystal (2015)

We achieved the convex growth interface shape in top-seeded solution growth of SiC applying non-axisymmetric solution convection induced by non-axisymmetric temperature distribution. The detailed solution flow, temperature distribution and carbon concentration distribution were calculated by 3-dimensional numerical analysis. In the present case, the solution flow below the crystal was unidirectional and the supersaturation was increased along the solution flow direction. By the rotation of the crystal in the unidirectional flow and the temperature distribution, we successfully obtained the crystal with the convex growth interface shape.
FOCUS: DEVELOPMENT AND APPLICATION OF TOF AND TOF/TOF MS: RESEARCH ARTICLE Mass Spectrometric Imaging of Red Fluorescent Protein in Breast Tumor Xenografts (2012)

Mass spectrometric imaging (MSI) in combination with electrospray mass spectrometry (ESI-MS) is a powerful technique for visualization and identification of a variety of different biomolecules directly from thin tissue sections. As commonly used tools for molecular reporting, fluorescent proteins are molecular reporter tools that have enabled the elucidation of a multitude of biological pathways and processes. To combine these two approaches, we have performed targeted MS analysis and MALDI-MSI visualization of a tandem dimer (td)Tomato red fluorescent protein, which was expressed exclusively in the hypoxic regions of a breast tumor xenograft model. For the first time, a fluorescent protein has been visualized by both optical microscopy and MALDI-MSI. Visualization of tdTomato by MALDI-MSI directly from breast tumor tissue sections will allow us to simultaneously detect and subsequently identify novel molecules present in hypoxic regions of the tumor. MS and MALDI-MSI of fluorescent proteins, as exemplified in our study, is useful for studies in which the advantages of MS and MSI will benefit from the combination with molecular approaches that use fluorescent proteins as reporters.
ChemInform Abstract: Yb(OTf)<sub>3</sub>‐Catalyzed 1,3‐Dipolar Cycloaddition of Nitrone with Alkene; Switch in Diastereoselectivity by Solvent and Bidentate Auxiliary. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Relationship between HBV/C subgenotypes and gene mutation of core promoter, precore/core region (2006)

目的 研究慢性乙型肝炎病毒(HBV)感染者中HBV基因型C亚型(HBV/C)的核心启动子、前C/核心区基因变异情况,分析HBV/C亚型的病毒学特征.方法 用酶联免疫法(ELISA)筛选出79例HBV/C,再用聚合酶链反应-限制性酶长度多态性分析方法(PCR-RFLP)进行HBV/C亚型分析;同时针对HBV核心启动子、preC/核心区基因进行半巢式PCR及PCR产物直接测序.结果 ①79例HBV/C中,33例(41.8%)为HBV/C1亚型,46例(58.2%)为HBV/C2亚型.②HBV/C1亚型仅见于来自中国南方的患者(P＜0.0001).③A1898位点变异仅见于HBV/C1亚型(P=0.056),V1753位点变异在HBV/C1亚型中多见(P＜0.05);HBV/C2以T1858(90%)、A1896(40%)位点变异多见(P＜0.008).T1762/A1764位点变异在HBV/C两种亚型中均常见.④肝细胞癌(HCC)患者中,V1753和T1762/A1764变异最常见(P＜0.05).结论 HBV/C1和HBV/C2在中国有明显的地区差异;V1753合并T1762/A1764双变异与发展为HCC相关,尤其在HBV/C1患者。
Sustained Homocysteine-Lowering Effect over Time of Folic Acid-Based Multivitamin Therapy in Stroke Patients despite Increasing Folate Status in the Population (2004)

The homocysteine-lowering effect of the active VITATOPS trial medication has not attenuated significantly in the past 5 years despite increasing voluntary fortification of foods with folic acid as reflected by a progressive rise in baseline folate status. These data suggest that in the continuing absence of a program of mandatory folate fortification of food in populations served by centers participating in the VITATOPS trial, the study will remain adequately powered to test the homocysteine-lowering hypothesis for which it was designed.
Synthesis and Evaluation of Novel Pyrazolo(1,5-a)pyrimidine Derivatives as Nonpeptide Angiotensin II Receptor Antagonists. (1995)

A novel series of 6-alkyl-7-oxo-4,7-dihydropyrazolo[1,5-alpha]pyrimidine-3-carboxyli c acid derivatives was prepared as angiotensin II (AII) receptor antagonists. When evaluated in an in vitro binding assay using COS cells transfected with a cDNA encoding a human AT1 angiotensin II receptor, the compounds in this series showed Ki values in the range of 0.4-4.0 nM. In anesthetized spontaneously hypertensive rats (SHRs), administration of the 6-propyl derivative 4d (1 mg/kg, i.v.) reduced the mean blood pressure (MBP) by a maximum of more than 30 mmHg from the normal value.
Elastic full-waveform inversion using 4C data acquisition (2012)

In the last four years there have been several attempts to execute full-waveform inversion (FWI) on 3D data sets. As field data or part of the data component is dominated with P waves, one feasible approach is to use acoustic approximation. This approach of FWI determines parameters related to the acoustic wave equation but mainly updates the velocities by minimizing the misfit between the observed data and the model data. The approach has shown tremendous potential especially in 3D wide-offset acquisitions using the pressure component of the collected data. This includes wide-azimuth streamer, ocean-bottom surveys and land types of geometries where the advantage of FWI has convinced the oil industry to pay close attention to the technology. The question still remains of how far can we properly describe the field data with the acoustic approximation, and at what point do we need to switch over to the much more expensive elastic wave equation implementation. If we acquire multi-component (4C) data, then we may be able to take advantage of the extra measured wavefields using elastic FWI. We previously demonstrated the application through synthetic data of which an example is an overthrust model and have also shown the uplift in a real data from the Gulf of Mexico (GoM).
Optimized Droplet Sizing of Water-in-Crude Oil Emulsions Using Nuclear Magnetic Resonance (2014)

Water-in-crude oil emulsions are an increasing problem during production. Essential to any emulsion breaking method is an ability to accurately measure droplet size distributions; this is rendered extremely difficult given that the samples are both concentrated and opaque. Here, we systematically consider the use of a standard, low-field benchtop nuclear magnetic resonance (NMR) apparatus to accurately measure the droplet size distributions. Such measurements are challenging because the NMR signal from the oil phase erroneously contributes to the measured water droplet size distribution. Conventionally, the oil-phase signal is nulled-out based on differences in the NMR T1 relaxation parameter between water and oil. However, in the case of crude oil, the oil presents a broad T1 distribution, rendering this approach infeasible. On the basis of this oil T1 distribution, we present an optimization routine that adjusts various NMR measurement timing parameters [observation time (Δ) and inversion time (Tinv)] to effectively eliminate this erroneous crude oil contribution. An implementation of this optimization routine was validated against measurements performed using unambiguous chemical-shift selection of the water (droplet) signal, as would conventionally be provided by high-field superconducting NMR spectrometers. We finally demonstrate successful droplet sizing of a range of water-in-crude oil emulsions.
Expansion of CD57 and CD62L-CD45RA+ CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection (1999)

Phenotypically defined activated CD8 T cells may have different functions in HIV infection. Activated CD8 T cells that are CD57 or CD62L(-)CD45RA+ may be beneficial, because their expansion in untreated patients correlates with a reduced viral setpoint after primary infection.
Defining ovarian failure in amenorrheic young breast cancer patients (2010)

At present, there is no gold standard test for the investigation of ovarian function in pre-menopausal breast cancer patients who develop amenorrhea after chemotherapy. Clinical, biochemical and biophysical investigations continue to be utilized in clinical practice, despite concerns regarding their predictive value for menopause. The resulting uncertainty about a woman's actual menopausal status has important consequences for patient management. These include choice of appropriate endocrine therapy, assessment of residual ovarian function and its effect on breast cancer recurrence, fertility issues and the prediction of the likelihood of conception. It is hoped that the development of novel surrogates may allow clinicians to more accurately assess menopausal status and thereby facilitate tailored and individualised therapy for this common group of patients.
NONPROSTHETIC MANAGEMENT OF PROXIMAL HUMERAL FRACTURES (2003)

Many proximal humeral fractures can be treated without the need for hemiarthroplasty. Treatment choice is affected by fracture location and pattern, as well as by patient factors including age, activity level, quality of bone, and ability to comply with a regimen of therapy. Successful diagnosis and treatment of proximal humeral fractures is dependent on good-quality radiographs, but in some cases, intraoperative assessment of the fracture pattern is required for a complete and accurate diagnosis of the fracture pattern and severity. A discussion of nonsurgical and surgical treatment options and techniques needed to achieve anatomic reduction and stable fixation is important.
A Morphing Blade for Wave and Wind Energy Conversion (2007)

The paper introduces a morphing blade for the application of wave and wind energy conversion. The most common and typical wave turbine, the Wells turbine, is symmetrical but rigid, whereas wind turbine blades are asymmetrical with some intended (adaptive) or unintended flexibility. Unlike the Wells turbine which is rigid, the morphing blade is flexible, allowing chord-wise bend from the leading to the trailing edge. The morphing blade discussed here is also symmetrical. It is based on an airfoil that is, in an unloaded state, geometrically similar to the NACA0012 airfoil, the Wells Turbine. The blade's flexibility results in a shape that differs from the NACA0012 airfoil if a load is applied. The intended function of the flexible blade has similarities to the function of blade flaps or ailerons and controlled deformations of flight surfaces with aerospace applications, introduced as a measure of improving efficiency and maneuverability of aircrafts at velocities other than the cruising speed. Efficiency of the new blade is higher than that of the rigid blades.
Abstract 700: Recellularization of Acellular Xenogenic Scaffold With Autologous Human Mesenchymal Stem Cells Rescues the Xenoreactive Immune Response (2019)

Background: Pre-clinical evidence suggests that structural valve deterioration (SVD) of bioprosthetic xenogenic tissue heart valves (XTHV) is a result of chronic immune rejection. Recellularization of XTHVs with human autologous cells represents one potential strategy to prevent this xenoreactive immune response and mitigate SVD. Methods: Bone marrow, human pericardium and heparinized whole blood was collected from adult patients undergoing elective cardiac surgery. Decellularized bovine pericardium underwent recellularization with hMSCs, which were isolated and cultured from the bone marrow, via co-incubation to allow for cell seeding. To examine the cell mediated immune response, we performed immunofluorescent staining for CD68+ macrophages and CD3+ T-cells and performed a proliferation assay to quantify T-cell proliferation. To investigate the humoral immune response, we performed an enzyme linked immunosorbent assay for pro-inflammatory cytokines TNF-α and INF-γ. Serum and PBMCs were collected for subsequent biochemical and flow cytometric analysis. Results: We show that decellularized bovine pericardium, exposed to human serum, had significantly decreased T-cell activation, represented by TNF-αand INF-γexpression, as well as a significant decrease in T-cell proliferation, when compared to wild-type bovine pericardium (p&lt;0.01). Moreover, when decellularized bovine pericardium was recellularized with autologous hMSCs and exposed to human serum, there was an additional decrease in TNF-α, INF-γexpression along with a further significant decrease in T-cell proliferation, when compared to both wild-type and decellularized bovine pericardium (p&lt;0.01). Importantly, recellularized XTHVs exposed to human serum had an equivalent expression of TNF-α, INF-γ and T-cell proliferation when compared to native human pericardium exposed to autologous human serum. Conclusions: Taken together, our data suggest that autologous human MSC recellularization of decellularized bovine pericardium abrogates the xenoreactive immune response. As such, autologous hMSC recellularization of an acellular xenogenic scaffolds may be an effective approach to decrease the progression of bioprosthetic SVD.
Performance analysis of combining techniques with correlated diversity (2005)

Diversity combining schemes are successfully applied in communication systems. In many recent publications the performance of different diversity combining schemes in different fading scenarios and with different modulation schemes was analyzed and analytical expressions for the performance derived. It turned out that the performance depends on the statistics of the fading, especially on the correlation of the diversity branches. In this work, we study the impact of correlation on the performance of the maximum ratio, equal gain, and selection combining schemes without computing directly the error rate. The performance depends only on the eigenvalues, i.e. powers, of the correlation matrix and not on the eigenvectors. Therefore, majorization theory can be used as a measure of the correlation. We show that the performance of maximum ratio combining and equal gain combining are Schur-convex functions with respect to the correlation eigenvalues, i.e. correlation increases the error rate. Surprisingly, the behavior of selection combining depends on the SNR: for small SNR, correlation decreases the error rate, whereas for high SNR, correlation increases the error rate. Finally, we illustrate the theoretical results by numerical simulations.
Application of Fatigue Life Prediction Methods for GMAW Joints in Vehicle Structures and Frames (2011)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;In the North American automotive industry, various advanced high strength steels (AHSS) are used to lighten vehicle structures, improve safety performance and fuel economy, and reduce harmful emissions. Relatively thick gages of AHSS are commonly joined to conventional high strength steels and/or mild steels using Gas Metal Arc Welding (GMAW) in the current generation body-in-white structures. Additionally, fatigue failures are most likely to occur at joints subjected to a variety of different loadings. It is therefore critical that automotive engineers need to understand the fatigue characteristics of welded joints.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The Sheet Steel Fatigue Committee of the Auto/Steel Partnership (A/S-P) completed a comprehensive fatigue study on GMAW joints of both AHSS and conventional sheet steels including: DP590 GA, SAE 1008, HSLA HR 420, DP 600 HR, Boron, DQSK, TRIP 780 GI, and DP780 GI steels. Dissimilar metal welds were made between DP590 GA and SAE 1008, DP 600 and SAE 1008, TRIP 780 and SAE 1008, DP 780 and SAE 1008, and Boron and HSLA. Fatigue behavior was evaluated for several different specimen geometries: single lap-shear, double lap-shear, butt weld, start-stop, and perch mount.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;Currently, many fatigue life prediction methods, such as structural stress approach, hot spot structural stress approach, notch stress approach, and local strain approach, are available to analyze GMAW joints. This study reviews two structural stress methods for fatigue life prediction of the welded joints, and it also assesses the two methods with previous A/S-P Sheet Steel Fatigue Committee fatigue test results.&lt;/div&gt;&lt;/div&gt;
Realizing Persistent-Spin-Helix Lasing in the Regime of Rashba-Dresselhaus Spin-Orbit Coupling in a Dye-Filled Liquid-Crystal Optical Microcavity (2022)

In the presence of Rashba-Dresselhaus coupling, strong spin-orbit interactions in liquid-crystal optical cavities result in a distinctive spin-split entangled dispersion. Spin coherence between such modes gives rise to an optically persistent spin helix. In this paper, we introduce optical gain in such a system, by dispersing a molecular dye in a liquid-crystal microcavity, and demonstrate an optically persistent spin-helix lasing in the Rashba-Dresselhaus regime.
Design and Performance of AC Superconducting Motors for Aerospace Electric Propulsion Systems (2017)

Poster
Inside Back Cover: The Formazanate Ligand as an Electron Reservoir: Bis(Formazanate) Zinc Complexes Isolated in Three Redox States (Angew. Chem. Int. Ed. 16/2014) (2014)

Formazans have been known since about 1900 for their intense color, and they find applications as dyestuffs and analytical reagents. In their Communication on page 4118 ff., E. Otten et al. describe formazanate anions as unique ligands in coordination chemistry. The facile and reversible redox chemistry accessible for these ligands allows the full characterization of bis(formazanate) zinc complexes in three oxidation states. Cover image courtesy of Hsin-Wei Lin.
Convex optimization for proximity maneuvering of a spacecraft with a robotic manipulator (2017)

Published in the proceedings of the 27th AAS/AIAA Spaceflight Mechanics Meeting, San Antonio, TX, Feb. 6-9, 2017. (Advances in the Astronautical Sciences, Volume 160, pp 1059-1078).
Involvement of the human splanchnic circulation in pressor response induced by handgrip contraction (1999)

We have analysed the adjustment of blood flow and vascular conductance in the abundantly supplied splanchnic circulation to a generally released pressor reaction. Pressor responses were induced by 2-min periods of standardized, sustained handgrip in seven healthy students. The effects of handgrip tests were followed both in the fasting state and after the consumption of a substantial, mixed meal. In the first of the two sessions, changes in superior mesenteric artery blood flow were recorded and concomitant changes in local vascular conductance derived. In the other session, pressor released cardiac output changes were recorded and changes in total peripheral vascular conductance derived. Both types of flow changes were recorded using ultrasound Doppler technique. Typically, blood flow in the superior mesenteric artery increased two- to threefold after a meal. Handgrip contractions induced an initial rapid increase in heart rate, cardiac output and total peripheral conductance, followed by a gradual decline in total peripheral conductance and stroke volume and a gradual increase in heart rate and mean arterial pressure for the rest of the period. At the end of 2-min pressor periods, total peripheral conductance was only about 10% below the pre-handgrip level, whereas vascular conductance locally in the area of the superior mesenteric artery decreased by some 30%. Thus, it appears that the splanchnic vascular bed contributes markedly to the compound pressor response. Handgrips caused significantly less reduction in local vascular conductance in the post-prandial than in the pre-prandial state, indicating that blood flow to the digesting gastrointestinal tract retains a relatively high priority also in a pressor situation.
Unsupervised Visual Domain Adaptation Using Subspace Alignment (2013)

In this paper, we introduce a new domain adaptation (DA) algorithm where the source and target domains are represented by subspaces described by eigenvectors. In this context, our method seeks a domain adaptation solution by learning a mapping function which aligns the source subspace with the target one. We show that the solution of the corresponding optimization problem can be obtained in a simple closed form, leading to an extremely fast algorithm. We use a theoretical result to tune the unique hyper parameter corresponding to the size of the subspaces. We run our method on various datasets and show that, despite its intrinsic simplicity, it outperforms state of the art DA methods.
Thank You for Two Exciting and Rewarding Years (2016)

Presents a message from Matt Barth thanking ITS society members for their support in his capacity as President of the ITS Society which is now ending.
Arenaviruses and Lethal Mutagenesis. Prospects for New Ribavirin-based Interventions (2012)

Lymphocytic choriomeningitis virus (LCMV) has contributed to unveil some of the molecular mechanisms of lethal mutagenesis, or loss of virus infectivity due to increased mutation rates. Here we review these developments, and provide additional evidence that ribavirin displays a dual mutagenic and inhibitory activity on LCMV that can be relevant to treatment designs. Using 5-fluorouracil as mutagenic agent and ribavirin either as inhibitor or mutagen, we document an advantage of a sequential inhibitor-mutagen administration over the corresponding combination treatment to achieve a low LCMV load in cell culture. This advantage is accentuated in the concentration range in which ribavirin acts mainly as an inhibitor, rather than as mutagen. This observation reinforces previous theoretical and experimental studies in supporting a sequential inhibitor-mutagen administration as a possible antiviral design. Given recent progress in the development of new inhibitors of arenavirus replication, our results suggest new options of ribavirin-based anti-arenavirus treatments.