gebhart/patrepeval huggingface dataset:
Azimuthal anisotropy of dijet events in PbPb collisions at $$ \sqrt{s_{\textrm{NN}}} $$ = 5.02 TeV (2023)

A bstract The path-length dependent parton energy loss within the dense partonic medium created in lead-lead collisions at a nucleon-nucleon center-of-mass energy of $$ \sqrt{s_{\textrm{NN}}} $$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:msub> <mml:mi>s</mml:mi> <mml:mi>NN</mml:mi> </mml:msub> </mml:msqrt> </mml:math> = 5 . 02 TeV is studied by determining the azimuthal anisotropies for dijets with high transverse momentum. The data were collected by the CMS experiment in 2018 and correspond to an integrated luminosity of 1.69 nb − 1 . For events containing back-to-back jets, correlations in relative azimuthal angle and pseudorapidity ( η ) between jets and hadrons, and between two hadrons, are constructed. The anisotropies are expressed as the Fourier expansion coefficients v n , n = 2–4 of these azimuthal distributions. The dijet v n values are extracted from long-range (1 . 5 &lt; |∆ η | &lt; 2 . 5) components of these correlations, which suppresses the background contributions from jet fragmentation processes. Positive dijet v 2 values are observed which increase from central to more peripheral events, while the v 3 and v 4 values are consistent with zero within experimental uncertainties.
Experiences with an alternative method for grounding personnel during sitting operation (2008)

One of the major requirements for safe handling of IC?s is the grounding of personnel. The paper presents data about the effectiveness of using the floor/footwear system as primary means of grounding personnel in standing and sitting operation. It also discusses whether there is a contradiction with International Standards like IEC 61340-5-1 or ANSI/ESD S20.20.
Aqueous manganese ion battery (2023)

An alternative grid energy storage system is described herein. In one embodiment, an electrochemical cell comprises a high specific surface area cathode (e.g., a cathode comprising a carbon nanofoam paper, a carbon nanotube mesh, a particulate carbon material, electrolytic manganese dioxide, or a manganese dioxide film), a zinc or lead anode (e.g., Zn or Pb foil), a selective ion-conductive separator that does not conduct zinc ions (e.g., a NAFION sulfonated tetrafluoroethylene based fluoropolymer-copolymer separator) between the anode and the cathode, and an aqueous electrolyte comprising a manganese salt (e.g., aqueous manganese sulfate) contacting the electrodes and the separator. A battery comprising two or more of the electrochemical cells electrically connected together in series, parallel, or both, also is described.
Dual Band and Dual Mode Microstrip Antenna for Body Centric Wireless Communication (2016)

A compact dual band and dual mode microstrip patch antenna, suitable for body centric wireless communication (BCWC) network is presented. The BCWC network works in two on-body and off- body modes. The proposed antenna has an outward radiation pattern for the off-body mode, which is suitable to communicate from on-body devices to off- body unite. Moreover, the antenna has an end-fire radiation pattern for the on-body mode, to communicate with other co-located worn devices from which data can be easily gathered. The proposed antenna resonances at 2.44 GHz (IEEE 802.11b/g) with 7.1 dB gain and linear polarization for the off-body mode and also at 5.43 GHz (IEEE 802.11a) with 6.6 dB gain and circular polarization for the on-body mode. Free space and on-body simulated and measured performances of the proposed antenna are shown. Specific absorption rate (SAR) value is also studied. The results show that the maximum averaged 10gr SAR is 0.26W/Kg for on-body mode when the antenna is placed on the chest of the human body model.
Hyperuricemia and overexcretion of uric acid increase the risk of simple renal cysts in type 2 diabetes (2017)

Previous studies have discussed the relationship between simple renal cysts (SRC) and serum uric acid level in healthy individuals. We performed a cross-sectional study to evaluate the association between serum uric acid level and fractional excretion of uric acid (FEUA) and simple renal cysts in males and postmenopausal females with type 2 diabetes. The overall prevalence of SRC was 18.1% in our population. SRC prevalence was significantly higher in hyperuricemic than normouricemic subjects (27.3% vs. 16.8%, P < 0.001). Subjects who overexcreted uric acid had a higher prevalence of SRC than underexcretors (total population: 21.6% vs. 16.3%; normouricemic subjects: 19.8% vs. 13.7%; hyperuricemic subjects: 50.0% vs. 22.7%, all P-values < 0.05). Hyperuricemia (odds ratio [OR] 1.824, 95% confidence interval [CI] 1.332-2.498, P < 0.001); FEUA (OR 1.046, 95% CI 1.002-1.091, P < 0.05); male gender (OR 1.922, 95% CI 1.489-2.480, P < 0.001); age (OR 1.049, 95% CI 1.035-1.064, P < 0.001); and albuminuria (OR 1.492, 95% CI 1.176-1.892, P < 0.01) were independent risk factors for SRC development. These findings suggested that hyperuricemia and high level of FEUA were both independent risk factors for SRC development in males and postmenopausal females with type 2 diabetes. Half of overproduction hyperuricemic patients had SRC.
ChemInform Abstract: NOTE ON METHODS FOR THE TRANSFORMATION OF 1,2‐DICARBOXYLIC ACIDS INTO α,β‐UNSATURATED MONOCARBOXYLIC ACIDS (1977)

Abstract Am Modellbeispiel des Diels‐ Alder‐Addukts (I) von Maleinsäureanhydrid und Butadien wird die Möglichkeit der Umwandlung von 1,2‐Dicarbonsäuren in α,β‐ungesättigte Carbonsäuren über zwei komplementäre Fragmentierungen von Derivaten des 3,6‐Dioxo‐perhydro‐l ,2‐oxazins (II) demonstriert.
Highly Active Mutants of Carbonyl Reductase S1 with Inverted Coenzyme Specificity and Production of Optically Active Alcohols (2005)

A wild type NADPH-dependent carbonyl reductase from Candida magnoliae (reductase S1) has been found not to utilize NADH as a coenzyme. A mutation to exchange the coenzyme specificity in reductase S1 has been designed by computer-aided methods, including three-dimensional structure modeling and in silico screening of enzyme mutants. Site-directed mutagenesis has been used to introduce systematic substitutions of seven or eight amino acid residues onto the adenosine-binding pocket of the enzyme according to rational computational design. The resulting S1 mutants show NADH-dependency and have lost their ability to utilize NADPH as a coenzyme, but retain those catalytic activities. Kinetic parameter V(max) and K(m) values of those mutants for NADH are 1/3- to 1/10-fold those of the wild type enzyme for NADPH. As a model system for industrial production of optically active alcohols, the S1 mutants can be applied to an asymmetric reduction of ketones, cooperating with a coenzyme-regeneration system that uses an NAD-dependent formate dehydrogenase.
Annotating off-label drug usage from unconventional sources (2022)

ABSTRACT Physicians have the freedom to prescribe medicines outside the list of approved indications, to treat mild to life-threatening clinical conditions and diseases, particularly when conventional treatments fail or are lacking. Off-label drug usage is more frequently observed in specific populations not often represented in clinical trials, e.g., pediatric, geriatric, or pregnant patients. Despite conflicting reports on patient safety, exploring alternative treatment options in medical practice promotes innovation and extends the applicability of current medicines. This process can be significantly improved by properly documenting and discussing off-label usage. This paper aims to document off-label uses discussed in less conventional sources, such as the r/medicine Reddit subforum. We identified 66 “Reddit off-label uses” (ROLUs) not captured in our reference database, DrugCentral ( https://drugcentral.org/ ), for a set of 40 drugs. These drugs are associated with 209 on-label drug indications (INDs) and 58 “non-Reddit” off-label uses (NROLUs). Most of these drugs are relatively ‘old’ (approved before 2000) and act on the nervous system, many with psychiatric applications. However, ROLUs are distinct from INDs and NROLUs. An automated scientific literature query showed that 90% of the ROLUs are linked to 4 scientific publications or more, with 80% linked to at least 10. A further search in the clinical trials database revealed 46 ROLUs mentioned; 39 are in phase 3 trials. These results indicate that most off-label uses discussed on the Reddit forum are supported by scientific evidence. We conclude that medical social media channels can provide a valuable source of alternative drug applications and should be scientifically explored and evaluated in the future.
Cholestane Glycosides from the Bulbs of <i>Ornithogalum </i><i>t</i><i>hyrsoides</i> and Their Cytotoxic Activity against HL-60 Leukemia Cells (2002)

Twelve bisdesmosidic cholestane glycosides (1-12), including nine new ones (1-9), were isolated from the bulbs of Ornithogalum thyrsoides by monitoring the cytotoxic activity on HL-60 leukemia cells. The structural assignment of the new compounds was carried out by spectroscopic analysis and the results of hydrolytic cleavage. The 3-O-monoglucosides with an aromatic acyl group at the C-16 diglycoside moiety (1, 12) were extremely cytotoxic, with respective IC(50) values of 0.00016 and 0.00013 microg/mL, and the other compounds, except for 2, 5, and 8, also showed cytotoxic activity as potent as etoposide (IC(50) 0.30 microg/mL), used as a positive control. These cholestanes were concluded to contribute to the potent cytotoxicity of the crude O. thyrsoides bulb extract.
High performance of microtubular solid oxide fuel cells using Nd<sub>2</sub>NiO<sub>4+δ</sub>-based composite cathodes (2014)

Cathodes of porous YSZ supports infiltrated with Nd<sub>2</sub>NiO<sub>4+δ</sub> nanoparticles are offered as an alternative solution for IT-SOFC cathodes, presenting maximum power densities of 0.4 W cm<sup>−2</sup> at 600 °C.
Gain-clamped operation of a linear laser amplifier with electrically variable gain (2002)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text A. R. Davies, K. A. Williams, R. V. Penty, I. H. White, M. Glick, D. McAuley, and P. J. Williams, "Gain-clamped operation of a linear laser amplifier with electrically variable gain," in Integrated Photonics Research, A. Sawchuk, ed., Vol. 78 of OSA Trends in Optics and Photonics (Optica Publishing Group, 2002), paper JW3. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Tuning the Photo‐electrochemical Performance of Ru<sup>II</sup>‐Sensitized Two‐Dimensional MoS<sub>2</sub> (2020)

Covalently tethering photosensitizers to catalytically active 1T-MoS<sub>2</sub> surfaces holds great promise for the solar-driven hydrogen evolution reaction (HER). Herein, we report the preparation of two new Ru<sup>II</sup> -complex-functionalized MoS<sub>2</sub> hybrids [Ru<sup>II</sup> (bpy)<sub>2</sub> (phen)]-MoS<sub>2</sub> and [Ru<sup>II</sup> (bpy)<sub>2</sub> (py)Cl]-MoS<sub>2</sub> . The influence of covalent functionalization of chemically exfoliated 1T-MoS<sub>2</sub> with coordinating ligands and Ru<sup>II</sup> complexes on the HER activity and photo-electrochemical performance of this dye-sensitized system was studied systematically. We find that the photo-electrochemical performance of this Ru<sup>II</sup> -complex-sensitized MoS<sub>2</sub> system is highly dependent on the surface extent of photosensitizers and the catalytic activity of functionalized MoS<sub>2</sub> . The latter was strongly affected by the number and the kind of functional groups. Our results underline the tunability of the photovoltage generation in this dye-sensitized MoS<sub>2</sub> system by manipulation of the surface functionalities, which provides a practical guidance for smart design of future dye-sensitized MoS<sub>2</sub> hydrogen production devices towards improved the photofuel conversion efficiency.
Primary visual cortical thickness in correlation with visual field defects in patients with pituitary macroadenomas: a structural 7-Tesla retinotopic analysis (2020)

All 8 patients showed significant positive correlations between V1 thickness and visual defect. These findings provide retinotopic maps of localized V1 cortical neurodegeneration spatially corresponding to impairments in the visual field. These results further characterize changes in the posterior visual pathway associated with chiasmatic compression, and may prove useful in the neuroophthalmological workup for patients with pituitary macroadenoma.
Abstract B42: Cyclic dinucleotides (CDNs) activated DC and NK cells in antitumor immunotherapy (2015)

Abstract Abstract Our laboratory developed cell based cancer vaccines (STINGVAX) that was formulated with cyclic dinucleotides that and sensed by STING to phosphorylate interferon regulatory factor3 (IRF3) and nuclear factor kappa-light-chain-enhancer (NF-κB) to induce B cells and myeloid cells to secrete IFN-β. IFN-β can active NK cells through Tyk2-STAT1 signaling pathway, and we found increased number of activated NK cells in tumor bearing mice treated with STINGVAX. In the context of formulation with GM-CSF secreting cellular vaccines, the anti-tumor effect of CDN was dependent on IFNα/β receptors. We found that CDN activated NK cells both in vitro and in vivo, and at the molecular level, CDN increased TYK2-STAT1 signaling. When we tested STINGVAX's anti-tumor efficacy with NK depletion, its anti-tumor effect was abrogated. Citation Format: Juan Fu, Qi Zhen, Drew Pardoll, Tom Dubensky, Young Kim. Cyclic dinucleotides (CDNs) activated DC and NK cells in antitumor immunotherapy. [abstract]. In: Proceedings of the AACR Special Conference: Tumor Immunology and Immunotherapy: A New Chapter; December 1-4, 2014; Orlando, FL. Philadelphia (PA): AACR; Cancer Immunol Res 2015;3(10 Suppl):Abstract nr B42.
Self-assembly of Au nanoparticles on graphene sheets as a catalyst with controlled grafting density and high reusability (2014)

Novel catalysts based on self-assembly of Au NPs on graphene oxide sheets through silane functionalization were reported.
Supplementary Tables from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling (2023)

&lt;p&gt;Supplementary Tables: Tissue microarray, antibody, primer, vector, siRNA, correlation analysis Information&lt;/p&gt;
Staff attitudes towards particular client difficulties in assertive outreach teams (2008)

Keyworkers expressed a number of positive and negative attitudes in relation to patient difficulties. Negative attitudes did not appear to be simply a feature of keyworker stress, however it is acknowledged that the sample size was small. Keyworkers' responses suggested a sense of personal failure when their patients were unwell or poorly engaged, despite patients being selected for assertive outreach on the basis of such difficulties. Recognition of negative attitudes may help in the improvement of training and supervision of staff members.
Applications of Nanomedicine in Breast Cancer Detection, Imaging, and Therapy (2014)

Worldwide, breast cancer remains as one of the most common cancer diagnosis and cause of cancer related death among women. Fortunately, nanomedicine has brought forth new potential and hope in breast cancer research. The extremely small size of nanoparticles makes it advantageous and potentially superior to use in tumor detection and imaging. One of the more extensively studied particles is quantum dots, semiconductor crystals which are capable of enhanced labeling and imaging of cancer cells. In addition, due to serious toxicity of chemotherapeutic agents, nano-formulations of breast cancer chemotherapy are under investigation and development. This may provide easier administering route and reduced frequency of drugs. With the use of nanoparticles, drug delivery can be carried out in a minimally invasive fashion and treatment regimens can be made much more targeted and specific for each patient. In this review article, we provide an overview on the role nanomedicine has played in breast cancer and mention some of the latest diagnostic and treatment modalities researched to date.
Isotope Effects and the Mechanism of an Electron-Transfer-Catalyzed Diels−Alder Reaction (2002)

The electron-transfer-catalyzed Diels-Alder reaction of indole and 1,3-cyclohexadiene was studied by a combination of experimental and theoretical methods. The (13)C kinetic isotope effects were determined at natural abundance by NMR methodology. B3LYP/6-31G* calculations allow for the first time a quantitatively accurate description of the different possible pathways and provide the basis for an analysis of the experimentally observed isotope effects. The computational results, in conjunction with experimental observations, show that the reaction has a stepwise mechanism that is initiated by attack of the diene into the 3-position of the indole. Numerical simulation of the experimentally observed isotope effects shows that the first step is rate-determining and that the electron exchange in the reactant contributes partially to the overall isotope effect. The combination of electronic structure theory, experimental isotope effects, and numerical simulation thus allows a detailed analysis of a complex reaction mechanism.
DEVELOPMENT OF THE NISSAN ASV-2 (2001)

This paper describes the Nissan ASV-2, an experimental advanced safety vehicle, and the technologies incorporated in this vehicle. The Nissan ASV-2 was developed during the second phase (FY 1996-2000) of the Advanced Safety Vehicle (ASV) program promoted by the Ministry of Land, Infrastructure and Transport. Newly developed technologies are incorporated into the vehicle specifically for reducing the number of traffic accidents overall. Overviews are given of the major individual systems that have been developed as Nissan ASV technologies, and several systems that are distinctive features of the ASV-2 are discussed in detail. For the covering abstract see ITRD E111577.
Roughness optimization of electron-beam exposed hydrogen silsesquioxane for immobilization of DNA origami (2012)

A novel way to immobilize deoxyribonucleic acid (DNA) origami on a conventional substrate using hydrogen silsesquioxane (HSQ) as a functionalized platform is demonstrated. An alternative approach to quantifying roughness of the HSQ surfaces for 2D DNA origami immobilization is also introduced. Effects of oxygen plasma treatment on the surface roughness and functionalization (for DNA origami immobilization) of exposed and developed HSQ patterns are characterized. Surface root mean square roughness of electron-beam exposed HSQ with various thicknesses is investigated and optimized down to 0.2 nm for ultrathin (sub-15 nm) HSQ patterns.
Mastering photoresponsive polymer surface thin films for control of neuron growth (2011)

International audience
Acute stress-induced hypersensitivity to colonic distension depends upon increase in paracellular permeability: role of myosin light chain kinase (2004)

Hypersensitivity to rectal or colonic distension characterizes most patients with IBS and increased gut permeability has been described in post-dysenteric IBS patients. However, no link has been established between these two events. The aim of this study was to determine (i) whether chemical blockade of stress-induced increase of colonic paracellular permeability by 2,4,6 triaminopyrimidine (TAP) affects the concomitant hypersensitivity to colonic distension, (ii) the role of epithelial cell contraction in the stress-induced increased permeability and hyperalgesia, using a myosin light chain kinase inhibitor (ML-7). The effect of acute partial restraint stress (PRS) on visceral sensitivity to colorectal distension (RD) was assessed by abdominal muscle electromyography. Colonic paracellular permeability was determined by measuring percentage of urinary 51Cr-EDTA recovery after intracolonic infusion. The effect of stress on both parameters was evaluated after TAP, ML-7 or vehicle pretreated animals. PRS significantly increased colonic paracellular permeability and the number of spike bursts for all volumes of RD applied compared to sham. TAP suppressed the stress-induced increase of colonic paracellular permeability and sensitivity to colonic distension. Similarly, ML-7 blocked the stress-induced increase of colonic paracellular permeability and sensitivity. Neither ML-7 nor TAP had any effect on both permeability and sensitivity in absence of stress. The increase of colonic permeability induced by PRS results from epithelial cell cytoskeleton contraction through myosin light chain kinase activation and this increase is responsible for stress-induced rectal hypersensitivity.
Pose Estimation for a Cuboid with Regular Patterns in an Interactive Assembly-support Projection System (2016)

Workers in factories often have to stop an operation to confirm various assembly instructions, for example, component numbers and/or the location to place a component; this is particularly the case with exceptional or inexperienced operations in a mixed-flow production line. These types of operation interruptions are one of the most significant factors linked to a decreasing productivity rate. In this study, we propose a novel method that estimates, in real time, the pose of a manufactured product on a production line without any augmented reality (AR) markers. This system projects instructions and/or component positions to help a worker process production information quickly. In this paper, we produced assembly-support system experimentally using projection-based AR. We develop a highly accurate object pose estimation method for manufactured products. The result of this experimental evaluation indicates that the combination of ORB and our algorithm can detect an object's pose more precisely than ORB only. We also develop an algorithm that is robust even if a part of an object is occluded by a worker's hand. We consider that this system helps workers understand instructions and component positions without the need to stop and confirm assembly instructions, thus enabling more efficient operation of tasks.
Complete genomes for hepatitis C virus subtypes 6f, 6i, 6j and 6m: viral genetic diversity among Thai blood donors and infected spouses (2007)

In this study, the first complete genome sequences for hepatitis C virus (HCV) subtypes 6f, 6i, 6j and 6m, obtained from infected blood donors in Chiang Mai, Thailand, are reported. Pairwise genome-wide nucleotide similarities between some of these isolates were higher than the 75-80% value used previously to define different HCV subtypes. To investigate further, the entire genomes of four prototype isolates, Th602 (6i), Th553 (6j), B4/92 (6m) and D86/93 (6n), were sequenced. Pairwise comparison of these sequences gave a similar range of nucleotide similarities, thereby providing new information for HCV subtype classification. In order to study the hypothesis of interspousal HCV transmission, four additional complete HCV genome sequences were obtained from two infected Thai blood donors and their spouses, C-0044 and C-0046 (6f), and C-0192 and C-0185 (6m). Pairwise comparison of the sequences revealed that C-0044 and C-0046 share a nucleotide similarity of 98.1%, whilst C-0185 and C-0192 have a similarity of 97.8%. Several other studies of partial HCV sequences of different genomic regions from HCV-infected couples have shown nucleotide similarities ranging from 96.3 to 100%. The similarities of the complete genome sequences from the two couples in the current study are consistent with HCV transmission between spouses.