gebhart/patrepeval huggingface dataset:
Pressure Induced Fusion (Pif) Liposomes: A Solventless Sterilizing Method for Producing Large Phospholipid Vesicles (1995)

We have recently described a new method to create liposomes of high captured volume we term interdigitation-fusion vesicles or IFVs (Ahl, et al. (1994) Biochim. Biophys. Acta 1195: 237–244). These vesicles arise from small (<100 nm) precursor liposomes comprised of saturated chain phospholipids which fuse upon induction to the interdigitated gel state after ethanol addition to form extensive sheets. When heated to the liquid crystalline state, these sheets vesicularize into large, predominantly unilamellar liposomes (IFVs). Here we report that a similar event occurs when hydrostatic pressures capable of causing acyl chain interdigitation are applied to small precursor vesicles of DPPC or DSPC. When DPPC small unilamellar vesicles were cycled three times between ambient pressure and 4.1 kbar (15 minute intervals) the resulting pressure induced fusion (PIF) vesicles had captured volumes of 13.1 ± 0.6 μl/μmole and were unilamellar as judged by 31P-NMR. Although three cycles yielded the maximum captured volume for DPPC, six pressurization cycles were required for DSPC but resulted in PIF vesicles of greater captured volume (27–37 μl/μmole). Conditions which interfere with bilayer interdigitation and have been shown to compromise IFV formation (i.e., cholesterol addition or the presence of cìs unsaturation) also compromised PIF vesicle formation. Significantly, temperatures and pressures ideal for PIF formation (40–60°C and 3.4–6.2 kbar) completely eradicated B, subtilis and B. stearothermophilus spores. The PIF procedure will be useful in a variety of biological and pharmacological applications because it avoids the use of organic solvent and allows sample sterilization at relatively low temperatures.
Preparation and Reactivity of Nanocrystalline Cocrystals Formed via Sonocrystallization (2006)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPreparation and Reactivity of Nanocrystalline Cocrystals Formed via SonocrystallizationDejan-Krešimir Bučar and Leonard R. MacGillivrayView Author Information Department of Chemistry, University of Iowa, Iowa City, Iowa 52242-1294 Cite this: J. Am. Chem. Soc. 2007, 129, 1, 32–33Publication Date (Web):December 15, 2006Publication History Received4 October 2006Published online15 December 2006Published inissue 1 January 2007https://pubs.acs.org/doi/10.1021/ja0671161https://doi.org/10.1021/ja0671161rapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views2377Altmetric-Citations140LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Crystal structure,Crystallization,Crystals,Reactivity,Solubility Get e-Alerts
Research and Clinical Implementation of Drug-Gene Interactions in Children (2018)

As momentum builds for precision medicine, one cornerstone of this personalized approach is pharmacogenomics. In adults, many clinicians have incorporated pharmacogenomic testing and genome-guided therapeutic decision making, either for routine prescribing of common drugs, or in the setting of specific circumstances such as serial therapeutic failures. The clinical implementation of pharmacogenomics in the care of pediatric patients lags behind that of adults, owing in large part to a lack of evidence supporting genome-guided therapy in this age group. There are several barriers to extrapolating data from adults or generating this evidence from studies in children. One is the distinct formulary of drugs used for children, many of which have not been interrogated for drug-gene associations. In addition, many drugs are used in children for pediatric-specific indications or with pediatric-specific side effect profiles. Furthermore, generation of convincing datasets is hindered by the small numbers of exposed pediatric patients and the variable impact of age on drug distribution and response. Several centers have developed innovative approaches to address these barriers, making strides in the use of clinical pharmacogenomics to provide personalized therapeutics to pediatric patients and in the investigation of drug-gene interactions in children.
Identification, activity, and structural studies of peptides incorporating the phorbol ester-binding domain of protein kinase C. (1995)

The family of homologous enzymes known as protein kinase C (PKC) has been the object of intense interest because of its crucial role in cellular signal transduction. Although considerable information about the activation of PKC has been gained through structure-activity, molecular modeling, and synthetic studies of both natural and designed activators, information about the structure of PKC itself has been limited by its large size and requirement for phospholipid cofactors. Additionally, difficulties in the purification of truncated mutants of PKC have thus far prevented their analysis by nuclear magnetic resonance (NMR) or x-ray crystallographic methods. We describe the identification, synthesis, ligand-binding analysis, cofactor requirements, and preliminary NMR evaluation of two subdomains (peptides B and C) of the regulatory domain of PKC-gamma. Peptides B and C bind [3H]phorbol 12,13-dibutyrate with good affinity (Kd = 6.4 microM and 414 nM, respectively) in the presence of phosphatidylserine. In comparison, the binding affinity of [3H]phorbol 12,13-dibutyrate for PKC was found to be 2.6 nM. Like PKC itself, these peptides also recognize other PKC activators, including dioctanoylglycerol and teleocidin B-4, and exhibit an ability to differentiate phorbol ester from its C-4 epimer. NMR studies of PKC subdomains are also described, indicating that both peptides B and C are well behaved in solution and do not exhibit any concentration-dependent changes. Finally, these studies reveal that peptide B becomes conformationally ordered only in the presence of phospholipid, suggesting that the regulatory domain of PKC itself might be organized for activation only when associated with the lipid bilayer, where its activator (diacylglycerol) is encountered.
Characterization of Japanese Texture Terms by Analyzing Relationships with Various Kinds of Foods (2018)

日本語テクスチャー用語445語と食物名の関係を明らかにすること，また，テクスチャー用語間の親近性や語彙構造を確認することを目的として，訓練された分析型パネルを評価者として質問紙調査および解析を行い，以下の結果を得た．
A BPTT-Like Optimal Control Algorithm With Vehicle Dynamics Control Application (2008)

The paper presents a gradient-based numerical algorithm for optimal control of nonlinear multivariable systems with control and state vectors constraints. The algorithm has a backward-in-time recurrent structure similar to the backpropagation-through-time (BPTT) algorithm, which is mostly used as a learning algorithm for dynamic neural networks. This paper presents an enhancement of the basic optimization algorithm. Our enhanced algorithm uses high-order Adams time-discretization schemes instead of the basic Euler discretization method, and a numerical calculation of Jacobians as an alternative to analytical Jacobians. Two examples are considered to illustrate the algorithm and its performance. The first example is that of a tubular reactor, for which an analytical solution is available, which can be readily used for validation of our approach. The second example is related to controlling vehicle dynamics based on a realistic high order model.
NFS Version 4 ACLs (2005)

NFS version 4 (specified in RFC 3530) Access Control Lists (ACLs)
provide more fine grained control than previous file permission
models, but before the full benefit of the model can be exploited,
some changes and clarifications must be made. This document will
describe the details that implementors should consider in order to
allow implementations to function and interoperate better.
Management of Patients With Erythropoietic Protoporphyria–Related Progressive Liver Disease (2019)

Erythropoietic protoporphyria (EPP) is an inherited metabolic disorder of heme synthesis resulting from overproduction of protoporphyrin IX (PPIX), which can lead to progressive liver disease characterized by recurrent EPP crises and end-stage liver disease. We used the Australian Transplant Registry to identify 5 patients referred for liver transplantation between 2008 and 2017. A total of 4 patients had EPP secondary to ferrochelatase deficiency, and 1 patient had X-linked EPP. No patient had follow-up with a specialist prior to the diagnosis of progressive liver disease. There were 3 patients who underwent orthotopic liver transplantation, whereas 2 died while on the transplant waiting list. Parenteral PPIX-lowering therapy was used in 4 patients and was effective in 3 patients, although 2 of these had rebound porphyria and worsening liver function following a decrease in the intensity of therapy. Early disease recurrence in the allograft following transplantation occurred in 2 patients requiring red cell exchange (RCE) to successfully attain and maintain low PPIX levels, but RCE was associated with hemosiderosis in 1 patient. Allogeneic stem cell transplantation (AlloSCT) was performed in 2 patients. One failed engraftment twice, whereas the second rejected the first graft but achieved full donor chimerism with a second graft and increased immunosuppression. In conclusion, our observations suggest that progressive liver disease needs parenteral PPIX-lowering treatment with the intensity adjusted to achieve a target Erc-PPIX level. Because EPP liver disease is universally recurrent, AlloSCT should be considered in all patients with adequate immunosuppression to facilitate engraftment. RCE appears to be effective for recurrent EPP liver disease but is associated with an increased risk of iron overload.
Pulmonary Embolism After Major Abdominal Surgery in Gynecologic Oncology (2006)

II-3.
The Trends of Pediatric Facial Fractures Due to Violence in a Level One Trauma Population (2019)

This study represents the largest US, single institution, Level 1 trauma center study of pediatric facial fractures. Pediatric patients with facial fractures due to a violent mechanism represent a distinct category of trauma patients with a unique profile of injuries.
Gas Holdup in an Impinging-Stream Reactor (2000)

In this work, correlations for predicting the mean gas holdup in the impinging stream reactor are presented. To develop these correlations, measurements with water and air were carried out in two geometrically similar reactors of different size. In addition, the radial distribution of the local gas holdup in a plane of the main tube of both reactors was measured.
Comparative Effectiveness of Endovascular Treatment for Acute Ischemic Stroke: A Population‐Based Analysis (2020)

Background A heterogeneous patient population receives endovascular treatment (EVT) for acute ischemic stroke caused by proximal large-vessel occlusion every day. We aimed to conduct a population-based study of EVT in the province of Alberta, Canada, to understand the effectiveness in a complete population and how the magnitude of effect differs from the artificial world of clinical trials. Methods and Results Within a 3-year period (April 2015 to March 2018), 576 patients fit the inclusion criteria of our study and constituted the EVT group of our analysis. The medical treatment group of the ESCAPE (Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion With Emphasis on Minimizing CT [Computed Tomography] to Recanalization Times) trial had 150 patients. Thus, our total sample size was 726. We captured outcomes in clinical routine using administrative data and a linked database method. Primary outcome of our study was home-time. Home-time refers to the number of days that the patient was back at premorbid living situation without increase in level of care within 90 days of index stroke event. Median age of patients was 70 years (interquartile range, 59-81 years), and 47.8% were women. Median National Institutes of Health Stroke Scale score was 17 (interquartile range, 13-20). EVT was associated with an increased 90-day home-time by an average of 8.5 days compared with medical treatment alone using Cragg hurdle regression (<i>P</i>=0.009). Age and higher National Institutes of Health Stroke Scale score were associated with decreased 90-day home-time (both <i>P</i><0.001). Multivariable logistic regression showed no association between EVT and mortality at 90 days (odds ratio, 0.76; 95% CI, 0.47-1.24). Conclusions EVT for acute ischemic stroke caused by proximal large-vessel occlusion was effective in our province-wide population-based study and results in an increase of 90-day home-time by ~8.5 days.
Persistence of SARS-CoV-2–Specific IgG in Children 6 Months After Infection, Australia (2021)

The duration of the humoral immune response in children infected with severe acute respiratory syndrome coronavirus 2 is unknown. We detected specific IgG 6 months after infection in children who were asymptomatic or had mild symptoms of coronavirus disease. These findings will inform vaccination strategies and other prevention measures.
The Effect of Forcing on Scalar Transport in a Co-Axial Combustor Geometry (1998)

Abstract This paper investigates open-loop control of the mixing between an inner heated stream and an outer unhealed stream in coaxial combustor geometry. The inner and outer streams mimic the gaseous fuel and primary air stream in a gas turbine combustor. Of specific interest in this study is the behavior of the coherent structures, and the mixing in these coherent structures under the effect of controlled perturbation of the primary air stream. Two perturbation or forcing frequencies are studied: the preferred mode or fundamental frequency of the unforced flow which is measured to be 500 Hz, and the subharmonic frequency of 250 Hz. At each forcing frequency, three different forcing levels were examined. At the high-forcing level, the preferred mode forcing produces an increase in the spreading rate of both the inner and the outer jets. This is associated with increased entrainment into the coherent structures and increased mixing of the heated inner and unheated outer jet. With subharmonic forcing, a similar behavior is observed due primarily to the emergence of the fundamental as a dominant mode. At low-level forcing, the velocity profiles are only marginally affected, but the temperature profiles indicate a decrease in mixing. It is speculated that this is associated with increased coherence but without an associated increase in entrainment into the coherent structures.
Sensitized Solar Cells based on Hexagonal Dyes of Terpyridine-Ruthenium(II): Effect of the Electropolymerization of Dyes during their Performance in Solar Cells (2006)

A study of the photovoltaic properties and performance for dye- sensitized solar cells, using three hexagonal macrocycles based on terpyridine-ruthenium (II) is reported. Photo- and electrochemical results suggest that the global conversion efficiencies for these devices were strongly dependent of the electropolymerization of dyes during the cells performance.
Hemoglonbin Typing by High Performance Liquid Chromatography (2015)

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Energy-efficient transmission for linearly precoded MIMO systems (2015)

Energy-efficient transmission of battery-powered devices is becoming more important in the mobile industry to improve device communications times on a battery charge. In this paper, we present a method to maximize energy efficiency (EE) at the mobile station transmitter for a packet-based multiple-input and multiple-output (MIMO) system. The system leverages channel state information for energy-efficient transmission with linear precoding. Methods and simulation results show that the solution of maximizing transmit energy efficiency depends on various factors such as transmit power, modulations, packet length, linear prccoding schemes and channel realizations.
Acoustic Analysis of a Single Cylinder Diesel Engine Using Biodiesel Fuel Blends (2015)

Fuel type has a direct effect on the quality of IC engine's combustion phenomenon. One of the most important quality parameters that can be fluctuated by fuel type is engine noise. The purpose of this study is to analyze the noise parameter of a diesel engine using B0, B5 (5% vol., biodiesel and 95% vol., diesel blends), B10, B15, B20, B25 and B30 biodiesel–diesel blends. This study was carried out at stationary position and at three positions such driver's left ear position (Drivers Left Ear Position-DLEP), 1.5 meter (1.5 meter Away From Exhaust-MAFE) and 7.5 meters (7.5 meter Away From Exhaust-MAFE) away from exhaust at 6 engine speeds (1200, 1400, 1600, 1800, 2000 & 2200 RPM). The results proved that the lowest and highest Sound Pressure Level (SPL) of power tiller takes place at B10, and B30 respectively. The SPL increased by 7.8 dB for increasing engine speed from 1200 to 2200 RPM. The test results showed that the average SPL at DLEP was 4.3 dB higher than 7.5 MAFE position. The dominant frequency of engine noise was315 Hz that exhaust structure is the source of it. In this frequency SPL of B10 was, 23%lower than thefuelB30 (a mixture of 30percentbiodiesel and70percentdieselfuel, respectively). The slightest and strongest sound by using theB10, B30 fuel mixture was produced respectively.
A high performance MEMS miniature tunable bandpass filter (2003)

A miniature tunable 3-pole filter is fabricated using coplanar waveguide (CPW) transmission-tines on glass substrate (C/sub r/ = 4.6, tan /spl delta/ = 0.006) and an array of RF-MEMS varactors. The filter is tuned using a bias voltage of 0-80 Volts. The filter is /spl sim/3.6 mm long and gives a near ideal frequency response. A tuning range of 14% from 18.6 to 21.4 GHz was achieved, with a constant fractional bandwidth of 7.4 /spl plusmn/ 0.1% and a mid-band insertion loss of 3.85-4.15 dB.
Blockmon (2012)

Passive network monitoring and data analysis, crucial to the correct operation of networks and the systems that rely on them, has become an increasingly difficult task given continued growth and diversification of the Internet. In this demo we present Blockmon, a novel composable measurement system with the flexibility to allow for a wide range of traffic monitoring and data analysis, as well as the necessary mechanisms to yield high performance on today's modern multi-core hardware. In this demo we use Blockmon's GUI to show how to easily create Blockmon applications and display data exported by them. We present a simple flow meter application and a more involved VoIP nomaly detection one.
Gallium Nitride as an Electromechanical Material (2014)

Gallium nitride (GaN) is a wide bandgap semiconductor material and is the most popular material after silicon in the semiconductor industry. The prime movers behind this trend are LEDs, microwave, and more recently, power electronics. New areas of research also include spintronics and nanoribbon transistors, which leverage some of the unique properties of GaN. GaN has electron mobility comparable with silicon, but with a bandgap that is three times larger, making it an excellent candidate for high-power applications and high-temperature operation. The ability to form thin-AlGaN/GaN heterostructures, which exhibit the 2-D electron gas phenomenon leads to high-electron mobility transistors, which exhibit high Johnson's figure of merit. Another interesting direction for GaN research, which is largely unexplored, is GaN-based micromechanical devices or GaN microelectromechanical systems (MEMS). To fully unlock the potential of GaN and realize new advanced all-GaN integrated circuits, it is essential to cointegrate passive devices (such as resonators and filters), sensors (such as temperature and gas sensors), and other more than Moore functional devices with GaN active electronics. Therefore, there is a growing interest in the use of GaN as a mechanical material. This paper reviews the electromechanical, thermal, acoustic, and piezoelectric properties of GaN, and describes the working principle of some of the reported high-performance GaN-based microelectromechanical components. It also provides an outlook for possible research directions in GaN MEMS.
Photonic crystal-enhanced quantum dot infrared photodetectors (2008)

Quantum dot infrared photodetectors (QDIPs) promise improved performance over existing technologies in the form of higher temperature operation and normal-incidence detection. Variation in the size of self-assembled quantum dots leads to a broadened spectral response, which is undesirable for multi-color detection. Photonic crystal slabs can filter the transmission of normally-incident light using Fano resonances, and thus may be integrated with QDIPs to create a narrowband detector. Finite-difference time-domain simulations were used to optimize such a filter for QDIPs grown by metal-organic chemical vapor deposition. The simulations predict that the integrated detector could show up to 76% decrease in the detector linewidth, with a tunable peak location. These devices were then fabricated by standard optical lithography, however the spectral width of the integrated device was similar to that of the unfiltered QDIP. This is attributed to imperfections in the filter, so alternative fabrication methods are discussed for future processing.
Using Filtered and Semicontinuous High Rate GPS for Monitoring Deformations (2009)

Multipath is a major sidereally repeating error affecting precise GPS positioning and deformation monitoring. Because satellite-receiver geometry repeats almost exactly every sidereal day, filtering can reduce multipath in near-static situations. Here, we investigate how sidereal filtering can be used in a switched multiantenna array system providing semicontinuous GPS data, which may be adopted in order to reduce hardware costs. Depending on the receiver’s setup, the optimum session switching interval is 119 s or a multiple thereof. This provides sufficient reliable epochs using a short switching interval, and is synchronized with the appropriate geometry repeat interval for sidereal filter application. The semicontinuous sidereally filtered GPS technique is efficient in detecting horizontal and vertical displacements, surpassing 5 and 8 mm precision, respectively, per epoch in near-static environments with moderately high multipath. This provides the capability of monitoring deformations occurring at periods greater than double the switching interval, although it can also be used for monitoring rapid structural deformations despite data gaps which may affect temporal resolution. Consequently, this combined method presents an efficient, cost-effective, and precise GPS technique.