gebhart/patrepeval huggingface dataset:
Assessing Actual Contribution of IF1, Inhibitor of Mitochondrial FoF1, to ATP Homeostasis, Cell Growth, Mitochondrial Morphology, and Cell Viability (2012)

F(o)F(1)-ATP synthase (F(o)F(1)) synthesizes ATP in mitochondria coupled with proton flow driven by the proton motive force (pmf) across membranes. It has been known that isolated IF1, an evolutionarily well conserved mitochondrial protein, can inhibit the ATP hydrolysis activity of F(o)F(1). Here, we generated HeLa cells with permanent IF1 knockdown (IF1-KD cells) and compared their energy metabolism with control cells. Under optimum growth conditions, IF1-KD cells have lower cellular ATP levels and generate a higher pmf and more reactive oxygen species. Nonetheless, IF1-KD cells and control cells show the same rates of cell growth, glucose consumption, and mitochondrial ATP synthesis. Furthermore, contrary to previous reports, the morphology of mitochondria in IF1-KD cells appears to be normal. When cells encounter sudden dissipation of pmf, the cytoplasmic ATP level in IF1-KD cells drops immediately (~1 min), whereas it remains unchanged in the control cells, indicating occurrence of futile ATP hydrolysis by F(o)F(1) in the absence of IF1. The lowered ATP level in IF1-KD cells then recovers gradually (~10 min) to the original level by consuming more glucose than control cells. The viability of IF1-KD cells and control cells is the same in the absence of pmf. Thus, IF1 contributes to ATP homeostasis, but its deficiency does not affect the growth and survival of HeLa cells. Only when cells are exposed to chemical ischemia (no glycolysis and no respiration) or high concentrations of reactive oxygen species does IF1 exhibit its ability to alleviate cell injury.
Abstract 17937: Effect of Remodulin in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction (PH-HFpEF) (2017)

Background: Pulmonary hypertension associated with heart failure with preserved ejection fraction (PH-HFpEF or CpcPH; WHO Group 2) is the most common cause of PH worldwide, and at present, it has n...
Strategic research initiative at the Research Techno Plaza (2005)

With novel synthesis methodologies, new molecules, and atomic scale engineering, tailored properties of materials yielding vastly superior electronic devices and even synthetic body parts seem to be within the realm of possibilities. The Advanced Materials Research Centre is a University-wide research centre that focuses on the synthesis of advanced and innovative functional materials for applications ranging from biotechnology to nanoelectronics. In addition optical, thermal and mechanical characterization of these materials to establish their functionality for the particular application needs to be evaluated. Towards this end, novel techniques for non-contact and wholefield characterization of materials have been developed.
Acceleration of polarized protons in the AGS (2010)

The high energy (s{sup 1/2} = 500 GeV) polarized proton beam experiments performed in RHIC, require high polarization of the proton beam. With the AGS used as the pre-injector to RHIC, one of the main tasks is to preserve the polarization of the proton beam, during the beam acceleration in the AGS. The polarization preservation is accomplished by the two partial helical magnets [1,2,3,4,5,6,7] which have been installed in AGS, and help overcome the imperfection and the intrinsic spin resonances which occur during the acceleration of protons. This elimination of the intrinsic resonances is accomplished by placing the vertical tune Q{sub y} at a value close to 8.98, within the spin-tune stop-band created by the snake. At this near integer tune the perturbations caused by the partial helical magnets is large resulting in large beta and dispersion waves. To mitigate the adverse effect of the partial helices on the optics of the AGS, we have introduced compensation quads[2] in the AGS. In this paper we present the beam optics of the AGS which ameliorates this effect of the partial helices.
Fluctuations in Finite Critical and Turbulent Systems (2001)

We show that hyperscaling and finite-size scaling imply that the probability distribution of the order parameter in finite-size critical systems exhibit data collapse. We consider the examples of equilibrium critical systems, and a statistical model of ecology. We propose an explanation for recent observations that the probability distribution of turbulent power fluctuations in closed flows is the same as that of the harmonic 2DXY model.
Accelerator Design And Calculated Performance Of The Los Alamos HIBAF Facility (2005)

The HIBAF 40 MeV accelerator and beam transport have been designed and studied with ISIS and PARMELA simulations. The nominal beam parameters for a 5 nC pulse are an emittance of 40 /spl pi/ mm mrad, 300 A peak current, and an energy spread of 0.25%. We will discuss the major design issues and report on performance expectations.
Abstract 2012: Off-target drug effects due to retroactivity in signaling pathways (2010)

Abstract A majority of targeted cancer therapeutics involve the specific inhibition of a molecular target in a signal transduction pathway. It is well known that targeted therapies, such as kinase inhibitors, may have effects on pathways other than those specifically targeted, whether by non-specific interactions or by indirect pathway cross-talk effects. The simplest view of signal transduction entails a cascade of molecular events initiated by the recognition of a stimulus and culminating in the chemical alteration of an effector molecule. We have recently shown that cascades can exhibit bidirectional signal propagation without the addition of regulatory feedback connections via a phenomenon termed retroactivity. Thus, retroactivity represents another potential source of off-target effects in signaling cascades. We have extended our previous work to a computational model which allows us to characterize the significance of the upstream off-target effect via retroactivity with a series of simple signaling networks using physiologically relevant parameters values. We aim to understand the dynamics of cancer signaling by integrating systems biology based models of signaling dynamics into our experimental investigations of breast cancer with the intent of both directing experiments and making predictions. One of the signaling networks we studied takes the form of two independent signaling cascades which have no regulatory feedback connections but are activated by the same upstream kinase. Our results suggest that under physiologically relevant conditions the application of an inhibitor near the bottom of one cascade can produce a significant change in concentration of a protein in the other cascade, even without a regulatory feedback connection between the two cascades. Developing a deeper understanding of bidirectional signal propagation in signal transduction pathways will be vitally important in the effort to develop safer and more effective targeted cancer therapies. Our modeling results challenge the notion that information in cascades only flows in the cell surface-to-nucleus direction and suggests that a perturbation applied within a cascade can produce both an upstream and a downstream effect. The notion of an upstream off-target effect is completely novel and may have significant implications if the perturbation takes the form of an inhibitory therapeutic drug. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 2012.
Enrichment of circulating trophoblasts from maternal blood using filtration-based Metacell® technology (2022)

In a cell-based non-invasive prenatal test (cbNIPT), intact circulating trophoblasts (CTs) are isolated from maternal blood for subsequent genetic analysis. Enrichment of these CTs from maternal blood is the most challenging step in the cbNIPT workflow. This study aims to assess the suitability of the filtration-based Metacell® technology to enrich CTs from maternal blood at week 10 to 13 of gestation. The Metacell® technology is a novel size-based enrichment technology that combines blood filtration through 8 μm pores with an in vitro culture method. Three protocols were evaluated. First, 8 mL or 16 mL of maternal blood was filtered and subsequently cultured in vitro on the separation membrane for 3 days in RPMI 1640. In addition, 16 mL of maternal blood was filtered, and immediately processed without further culturing. Y-chromosome-specific qPCR or STR analysis was performed to evaluate the enrichment of CTs. A total of 44 samples from pregnant women, out of which 26 were carrying a male fetus, were processed. Although five enriched male fetus samples show detectable male DNA quantities, it cannot be excluded that the obtained positive signal is caused by cell-free fetal DNA sticking to the Metacell® separation membrane. In conclusion, the Metacell® technology, tested as described, is not suitable for consistent enrichment of CTs.
Implantable Electrochemical Sensors for Biomedical and Clinical Applications: Progress, Problems, and Future Possibilities. (2007)

Biosensors are of great interest for their ability to monitor clinically important analytes such as blood gases, electrolytes, and metabolites. A classic example is to monitor the dynamics of blood-glucose levels for treating diabetes. However, the current practice, based on a three decade old technology, requires a drop of blood on a test strip, which is in dire need of replacement. The increasing demands and interests in developing implantable glucose sensors for treating diabetes has led to notable progress in this area, and various electrochemical sensors have been developed for intravascular and subcutaneous applications. However, implantations are plagued by biofouling, tissue destruction and infection around the implanted sensors and the response signals must be interpreted in terms of blood or plasma concentrations for clinical utility, rather than tissue fluid levels. This review focuses on the potentials and pitfalls of implantable electrochemical sensors and presents our opinions about future possibilities of such implantable devices with respect to biocompatibility issues, long-term calibration, and other aging effects on the sensors.
A Novel Capacitive Detection Principle for Coriolis Mass Flow Sensors Enabling Range/Sensitivity Tuning (2015)

We report on a novel capacitive detection principle for Coriolis mass flow sensors which allows for one order of magnitude increased sensitivity. The detection principle consists of two pairs of comb-structures: one pair produces two signals with a phase shift directly dependent on the mass flow, the other pair is used to cancel the actuation signal. This results in larger phase shifts for the same mass flows. The range and sensitivity of the sensor can be tuned by changing the amount of cancellation of the actuation frequency, e.g. the size ratio between the comb-pairs.
Urinary TNF-binding protein (TNF soluble receptor) protects mice against the lethal effect of TNF and endotoxic shock. (1993)

We tested the effect of urinary TNF-binding protein (uTBP) on the toxic effect of TNF (0.5 micrograms/mouse, i.v.) in adrenalectomized mice sensitized with IL-1 to increase susceptibility to TNF. In this experimental model, mortality was 67%, but decreased to 13% when uTBP (250 micrograms/mouse, i.v.) was administered simultaneously with TNF. The protective effect of uTBP was dose-dependent, and time course experiments indicated a protective effect when uTBP was administered before or up to one hour after TNF. Some protection was also obtained when uTBP was given three hours after TNF. Urinary TBP improved the survival of mice after a lethal dose of LPS (1.2 mg/mouse, i.p.), suggesting its possible efficacy in the therapy of septic shock or other TNF-mediated pathologies.
ChemInform Abstract: Mild Conditions for the Removal of Acid‐Labile Protective Groups. (1989)

Abstract Some acid‐labile protecting groups such as dimethyl acetals, e.g. in compound (I), tetrahydropyranyl ethers, or trityl ethers are cleaved upon treatment with hydrogen peroxide and trichloroacetic acid.
Modeling of Location Estimation for Object Tracking in WSN (2013)

Location estimation for object tracking is one of the important topics in the research of wireless sensor networks (WSNs). Recently, many location estimation or position schemes in WSN have been proposed. In this paper, we will propose the procedure and modeling of location estimation for object tracking in WSN. The designed modeling is a simple scheme without complex processing. We will use Matlab to conduct the simulation and numerical analyses to find the optimal modeling variables. The analyses with different variables will include object moving model, sensing radius, model weighting value α , and power-level increasing ratio k of neighboring sensor nodes. For practical consideration, we will also carry out the shadowing model for analysis.
26A. Crystal structure of a recombinant ??EC domain from human fibrinogen-420 (1998)

Spraggon, G.; Applegate, D.; Everse, S. J.; Zhang, J. Z.; Veerapandian, L.; Redman, C.; Doolittle, R. F.; Grieninger, G. Author Information
Tinidazole for bacterial vaginosis (2007)

Tinidazole has been used for bacterial vaginosis (BV) outside the USA for almost four decades. Tinidazole has recently been resurrected and FDA approved for trichomoniasis and BV in the USA and is being restudied as an alternative to metronidazole for BV. In vitro antimicrobial activity and pharmacokinetics studies indicate that when compared directly with metronidazole, tinidazole has minor but possibly relevant antimicrobial as well as pharmacokinetic advantages. Clinical comparisons have been infrequent, although the limited head-to-head studies indicate minimal therapeutic advantage with tinidazole. Perhaps the more relevant differences relate to the enhanced tolerance and reduced toxicity of tinidazole. Currently, studies are still ongoing directly comparing the clinical efficacy of metronidazole and tinidazole. These studies should establish the role of tinidazole in the treatment of BV; however, cure rates are unlikely to be significantly different.
ChemInform Abstract: Nonaqueous Diazotization of Arylamines in the Presence of Dimethyl Disulfide; the Convenient Synthesis of Aryl Methyl Sulfides from Anilines. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mobility and trapping time in HgI/sub 2/: a comparison of measurement methods and results (1982)

The charge transport parameters of a solid-state nuclear radiation detector are of paramount importance in determining the spectrometric performance. The free drift lengths (lambda) for electrons and holes are given in terms of the products of mobility (..mu..) and trapping time (tau) for electrons and holes. For good spectrometric performance the carrier free drift lengths should be much greater than the thickness of the detector. The ..mu.. tau product is so important in this regard that different solid-state detector materials are compared on the basis of their ..mu.. tau values, and for a given material progress is gauged by the current value of ..mu.. tau which it is possible to achieve. Workers in the field are fond of plotting ..mu.. tau versus time (in years, usually) to show how the state-of-the-art is advancing, often towards some asymptotic value. Different methods of measuring the charge transport parameters of mercuric iodide (HGI/sub 2/) are discussed and experimental values are presented. (WHK)
[Circadian chronotherapy for metastatic liver tumor]. (2013)

Efficacy of circadian chronotherapy for liver metastases from colorectal cancer was evaluated. Chronomodulated infusion of anticancer drugs via the hepatic artery(HAI) was applied for patients with marginally resectable or unresectable liver metastases at initial diagnosis. Response rate of chemotherapy and frequency of liver resection after chemotherapy of patients treated with chronomodulated HAI were higher than those treated with flat HAI. Further, combination of chronomodulated regional HAI and systemic chemotherapy was the most effective prehepatectomy chemotherapy for the treatment of patients with advanced colorectal liver metastases. Based on these results, we are now performing phase II non-randomized open labeled trial of chronomodulated HAI with systemic administration of panitumumab for patients with such advanced liver metastases (ccFLAP trial). Circadian chronotherapy is an effective prehepatectomy chemotherapy for the treatment of patients with advanced and aggressive liver metastases from colorectal cancer.
Results of Polyaxial Locked-Plate Fixation of Periarticular Fractures of the Knee (2008)

The variable-axis locking plates performed well, with a high rate of fracture union and no evidence of varus collapse due to failure of the polyaxial screw fixation, in a series of complex fractures about the knee. Complication rates were similar to those for historical controls treated with fixed-trajectory locking plates. Polyaxial locking plates offer more fixation versatility without an apparent increase in mechanical complications or loss of reduction.
Comparable incidence of periprosthetic tibial fractures in cementless and cemented unicompartmental knee arthroplasty: a systematic review and meta‐analysis (2021)

V.
Private Exploration Primitives for Data Cleaning. (2017)

Data cleaning, or the process of detecting and repairing inaccurate or corrupt records in the data, is inherently human-driven. State of the art systems assume cleaning experts can access the data (or a sample of it) to tune the cleaning process. However, in many cases, privacy constraints disallow unfettered access to the data. To address this challenge, we observe and provide empirical evidence that data cleaning can be achieved without access to the sensitive data, but with access to a (noisy) query interface that supports a small set of linear counting query primitives. Motivated by this, we present DPClean, a first of a kind system that allows engineers tune data cleaning workflows while ensuring differential privacy. In DPClean, a cleaning engineer can pose sequences of aggregate counting queries with error tolerances. A privacy engine translates each query into a differentially private mechanism that returns an answer with error matching the specified tolerance, and allows the data owner track the overall privacy loss. With extensive experiments using human and simulated cleaning engineers on blocking and matching tasks, we demonstrate that our approach is able to achieve high cleaning quality while ensuring a reasonable privacy loss.
P1‐322: UTILITY OF THE COGNIGRAM BRIEF BATTERY IN ASSESSING COGNITIVE CHANGES ASSOCIATED WITH AB AND APOE GENOTYPE IN PRECLINICAL ALZHEIMER'S DISEASE (2014)

The Cognigram brief battery, which consists of four card-playing tasks that assess psychomotor function, attention, visual learning, and visual working memory, has been shown to be a useful screening tool in clinical settings. Previous studies have demonstrated the sensitivity of this battery in detecting cognitive impairment and cognitive decline in individuals with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Prospective studies in healthy, non-demented older adults have also shown that the Cognigram brief battery is sensitive to detecting cognitive changes associated with high A β. However, the apolipoprotein E (APOE) ε4 allele was unrelated to the rate of Aβ-related memory decline in these studies. This is surprising, as in vitro studies have indicated a role for apoE in increasing Aβ accumulation and reducing its clearance. One interpretation of these findings is that the Ɛ4-related risk for AD is only an indirect estimate of the risk for AD posed by high Aβ, or that extant studies recruited small samples and conducted follow-up assessments that were too brief. Thus, this study aimed to determine the utility of the Cognigram brief battery in characterizing cognitive decline associated with Aβ and APOE ε4 in a larger sample of healthy, non-demented older adults over a 54-month period of time. Healthy adults (n=333) enrolled in the Australian Imaging, Biomarkers and Lifestyle (AIBL) study underwent Aβ neuroimaging. The Cognigram brief battery was administered at baseline, 18-, 36- and 54-month follow-ups. Aβ PET neuroimaging was used to classify participants as Aβ− or Aβ+ and APOE genotype was ascertained from blood samples. Relative to the Aβ−ε4− group, the Aβ+ε4+ group showed significantly faster rates of cognitive decline across all domains over the 54-month study period (d =0.45-0.72); Aβ+ε4− individuals did not show significantly faster decline on any cognitive measure. There were also no differences in rates of cognitive change between Aβ−ε4− and Aβ−ε4+ groups. Results of this study suggest that the Cognigram brief battery is a useful tool that may be used to monitor subtle cognitive changes associated with Aβ and APOE ε4 in otherwise healthy, non-demented older adults.
Modeling and Optimization of Production Process: Lessons from Traffic Dynamics (2004)

This chapter contains sections titled: Modeling the Dynamics of Supply Networks Modeling One-dimensional Supply Chains “Bull-whip Effect” and Stop-and-Go Traffic Dynamical Solution and Resonance Effects Discussion of Some Control Strategies Production Units in Terms of Queueing Theoretical Quantities Calculation of the Cycle Times Feeding Rates, Production Speeds and Inventories Impact of the Supply Network's Topology Advantages and Extensions Many-particle Models of Production Processes Learning from Pedestrians Optimal Self-organization and Noise-induced Ordering “Slower-is-Faster Effect” in Merging Flows Optimization of Multi-object Flows Summary and Outlook Bibliography
Extended coherence length megahertz FDML and its application for anterior segment imaging (2012)

We present a 1300 nm Fourier domain mode locked (FDML) laser for optical coherence tomography (OCT) that combines both, a high 1.6 MHz wavelength sweep rate and an ultra-long instantaneous coherence length for rapid volumetric deep field imaging. By reducing the dispersion in the fiber delay line of the FDML laser, the instantaneous coherence length and hence the available imaging range is approximately quadrupled compared to previously published MHz-FDML setups, the imaging speed is increased by a factor of 16 compared to previous extended coherence length results. We present a detailed characterization of the FDML laser performance. We demonstrate for the first time MHz-OCT imaging of the anterior segment of the human eye. The OCT system provides enough imaging depth to cover the whole range from the top surface of the cornea down to the crystalline lens.
Plasmonic effects in amorphous silicon thin film solar cells with metal back contacts (2012)

Plasmonic effects in amorphous silicon thin film solar cells with randomly textured metal back contact were investigated experimentally and numerically. The influence of different metal back contacts with and without ZnO interlayer was studied and losses in the individual layers of the solar cell were quantified. The amorphous silicon thin film solar cells were prepared on randomly textured substrates using large area production equipment and exhibit conversion efficiencies approaching 10%. The optical wave propagation within the solar cells was studied by Finite Difference Time Domain simulations. The quantum efficiency of solar cells with and without ZnO interlayer was simulated and the interplay between the reflection, quantum efficiency and absorption in the back contact will be discussed.