gebhart/patrepeval huggingface dataset:
Geophysical Tests for Intermediate-Range Forces (1993)

Abstract : The suggestion in 1986 of a possible 'fifth force' in Nature led to considerable experimental and theoretical effort to detect such a force, and deviations from Newtonian gravity. Geophysical experiments play an important role in the detection of such a force, because the natural scale of geophysical experiment covers a range that is not readily accessible via other methods. This work describes several investigations which search for the presence of non- Newtonian gravity. These include a new tower experiment, and an analysis of exponential models of non-Newtonian gravity. In the course of carrying out the tower experiment problems were encountered in working with the Global Positioning System, and these are described in detail. As a result of this work we can say that support for the validity of Newtonian gravity over geophysical scales has increased. Non-Newtonian Gravity Gravitational Physics.
Anti-VEGF therapies for age-related macular degeneration: a powerful tactical gear or a blunt weapon? The choice is ours (2021)

This review shows that by implementing existing health care systems and dispensing adequate therapies in the field of retinal diseases, the prevalence of blindness due to these conditions can decline.
Effects of green tea catechins in a rat multi-organ carcinogenesis model (1993)

The effects of dietary administration of green tea catechins (GTC) were examined using a multi-organ carcinogenesis model. Groups of 15 F344 male rats were initially treated with a single i.p. administration of 100 mg/kg body wt N-diethyl-nitrosamine, 4 i.p. administrations of 20 mg/kg body wt N-methylnitrosourea, 4 s.c. doses of 40 mg/kg body wt 1,2-dimethylhydrazine, together with 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine for 2 weeks and then 0.1% 2,2'-dihydroxy-di-n-propylnitrosamine for 2 weeks, both in the drinking water, for a total initiation period of 4 weeks. GTC in the diet, at doses of 1.0 or 0.1%, was administered from 1 day before and during carcinogen exposure, after carcinogen exposure or both during and after carcinogen exposure. Further groups of animals were treated with carcinogen, 1% GTC or basal diet alone as controls. All animals were killed at the end of week 36, and all major organs examined histopathologically. The numbers of small intestinal tumors (adenomas and carcinomas) per rat were significantly reduced in the groups treated with 1% GTC during (0.13 +/- 0.35) and after carcinogen exposure (0.31 +/- 0.48) and in those receiving 1% and 0.1% GTC both during and after carcinogen exposure (0.14 +/- 0.36, 0.46 +/- 0.97 respectively) as compared with the carcinogen alone group (1.07 +/- 1.21). On the other hand, numbers of glutathione S-transferase placental form positive liver foci per cm2 were slightly but significantly increased in the groups treated with 1 and 0.1% GTC during carcinogen exposure, 1% GTC after carcinogen exposure and 1% GTC both during and after carcinogen exposure. The results indicated that while GTC inhibits small intestinal carcinogenesis it slightly enhances hepatocarcinogenesis in a dose dependent manner when applied both during and after carcinogen exposure.
Septic Arthritis Caused by Propionibacterium acnes (1982)

The traditional view that Propionibacterium acnes is nonpathogenic for man, except as an agent associated with acne vulgaris, has been refuted. Propionibacterium acnes has been shown to cause endocarditis, meningitis, and other serious infections. We report a case of P acnes infection causing septic arthritis and contributing to a concurrent soft-tissue infection. This case supports and extends previous observations of the clinical importance of P acnes as a pathogen. A positive culture for P acnes cannot be uncritically dismissed as a bothersome contaminant without considering the clinical circumstances.
Photosensitive junctions based on UV-modified graphene and inkjet-printed organic molecules (2020)

In this work, we report a novel method of mask-less doping of graphene channel in field-effect transistor configuration<br> by local inkjet printing of organic semiconducting molecules. Graphene-based transistor was fabricated via large-scale<br> technology, allowing for upscaling electronic device fabrication and lowering the device cost. The altering of<br> functionalization of graphene was performed through local inkjet printing of semiconducting molecules: N,N′-Dihexyl-<br> 3,4,9,10-perylenedicarboximide (PDI-C6), 5,5′′′-Dihexyl-2,2′:5′,2′′:5′′,2′′′-quaterthiophene (HEX-4T-HEX) and<br> polyalanine (PANI). We found the effect of UV treatment on fabrication of graphene/organic junctions because of<br> change in graphene hydrophobic properties. We demonstrated the high resolution (about 50 μm) and accurate printing of<br> organic ink on UV treated chemical vapor deposited (CVD) graphene. The PANI/graphene junction demonstrate more<br> stable photoresponse characteristic for 470 nm diode illumination. The characteristics of PDI/graphene junction<br> demonstrate the saturation for high diode power because of organic crystals degradation. The photoresponse of 1 mA/W<br> was demonstrated for PANI/graphene junction at 0.3 V bias voltage. The developed method opens the way for local<br> functionalization of on-chip array of graphene by inkjet printing of different semiconducting organic molecules for<br> photonics and electronics application.
Countercurrent Heat Exchange Building Envelope Using Ceramic Components (2020)

Research and development in building envelope design have promoted the convergence of two system types, Thermo-Active Building Systems and Adaptive Building Envelopes, that re- conceptualize the envelope as a distributed energy transfer function that captures, transforms, stores, and even re-distributes energy resources. The widespread deployment of Thermo-Active Building Systems as a building envelope will depend on several factors. These factors include the value of the design attributes that impact energy transfer in relation to the performance of the building envelope assembly and the return on investment that these attributes individually or in the aggregate can provide as a reduction in Energy Use Intensity. The research focus is on the design development, testing, and energy reduction potential of a Thermo-Active Building System as an adaptive countercurrent energy exchange envelope system using ceramic components: the Thermal Adaptive Ceramic Envelope.
Development of Lightweight Titanium Base Alloys (1989)

The goal of the program on Development of Lightweight Titanium Base Alloys was to develop new titanium alloys with 10% lower density, 50% higher elastic modulus, and 50% higher strength than Ti-6Al-4V and a 150 deg C increase in service temperature above that of Ti-6Al-2Sn-4Zr-2Mo. The feasibility of adding significant amounts of Be, Li, and Mg to Ti base alloys to effect these improvements was investigated. Rapid solidification processing was employeed to obtain extended solid solutions of Be concentrations far exceeding the limits indicated by the equilibrium phase diagram. This solid solution was expected to provide significant strengthening because of the atomic-radius mismatch between Ti and solute atoms, and to provide dispersion strengthening via fine dispersions. Master alloys of Ti-Al-Be and Ti-V-Al-Be were produced by melting pieces of Lockalloy (60 wt%) Be - 40 wt% Al) and elemental additions in a Beo- wash-coated alumina crucible, and casting at 1450 deg C into a chilled mold. Powder was produced by melting the master alloys in an uncoated graphite crucible, initiating metal flow at 1300 deg C, and dispersing the stream by centrifugal atomization. Target alloy chemistries were obtained, although the powders contained 0.5-0.7 wt% oxygen. This oxygen pickup occurred during casting and is attributed to the BeO wash and/or the relatively poor vacuum. The powders were extruded into 12-cm diameter rods at 900 and 950 deg C (except Ti-34Al-4Be which was extruded at 1150 deg C). Successful extrusions were obtained for Ti- 6Al-4V-4Be, Ti-6Al-4V-7Be, Ti-25V-3Al-4Be, Ti25V-4Al-7Be, and TI34Al-4Be.
Effect of intrathecal glucocorticoids on the central glucocorticoid receptor in a rat nerve ligation model (2017)

Intrathecal MPA treatment after SNL did not result in lower tGR and pGR levels within the SDH and DRG compared to saline controls. In present study we did not differentiate between the various isoforms of the GR which might clarify this finding.
Equivalent RHS Approach for the Design of EHS in Axial Compression or Bending (2012)

The use of steel elliptical hollow sections (EHS) has grown steadily, but the implementation of EHS has been done without appropriate design guidelines or procedures. A pragmatic objective has been to develop a section conversion method to transform the EHS into an equivalent shape for which design equations and guidelines already exist. This paper further explores the equivalent RHS (rectangular hollow section) approach for member design. By using the equivalent RHS approach to convert the EHS into an equivalent RHS, the validity of existing RHS cross-section classification limits and member design equations are demonstrated for EHS columns subjected to axial compression that buckle about the major axis and the minor axis, and EHS beams subjected to bending about the major axis and the minor axis. The equivalent RHS approach is a single consistent and rational procedure, and it is shown to be a viable method for designing EHS compression members and flexural members.
Investigations towards easy-to-fabricate effective athermal fibers for high average power lasers (2022)

We investigate simplified fiber designs to mitigate thermal effects that limit the power scaling of large-mode area high-average power fiber lasers. We discuss the advantages of lowering the thermo-optical coefficient of the Yb active-doped core for different fiber designs. We demonstrate that mode shrinking can be fully suppressed not only in step index fibers, but also in more advanced ones such as large pitch fibers. Additionally, this approach will lead to a mitigation of transversal mode instabilities. We present first results with a step index fiber, where the influences of the co-dopants used to decrease the thermo-optical coefficient are discussed.
Isomerically selective photoionization of mercury-197 (1985)

We report the second of a series of experiments on selective photoionization of mercury isotopes in which we show that radioactive atoms containing either isomeric form of the radionuclide 197Hg can be selectively ionized in the presence of natural mercury isotopes by doubly resonant three-step laser photoionization, and discuss its implications as a test case for nuclear-isomer separation.
Label Distribution Protocol Extensions for Point-to-Multipoint and Multipoint-to-Multipoint Label Switched Paths (2011)

This document describes extensions to the Label Distribution Protocol
(LDP) for the setup of point-to-multipoint (P2MP) and multipoint-to-
multipoint (MP2MP) Label Switched Paths (LSPs) in MPLS networks. These
extensions are also referred to as multipoint LDP. Multipoint LDP
constructs the P2MP or MP2MP LSPs without interacting with or relying
upon any other multicast tree construction protocol. Protocol elements
and procedures for this solution are described for building such LSPs
in a receiver-initiated manner. There can be various applications for
multipoint LSPs, for example IP multicast or support for multicast in
BGP/MPLS Layer 3 Virtual Private Networks (L3VPNs). Specification of
how such applications can use an LDP signaled multipoint LSP is
outside the scope of this document. [STANDARDS-TRACK]
Exposure-response relationships for everolimus in de novo kidney transplantation: defining a therapeutic range (2002)

A significantly increased risk of acute rejection was observed at everolimus trough levels <3 ng/ml. This is a lower therapeutic concentration limit when everolimus is used with conventionally dosed cyclosporine. Because hyperlipidemias responded to counter-measure therapies and thrombocytopenia had an overall low incidence of 12%, everolimus-related adverse events were manageable up to the highest troughs observed in this population of 15 ng/ml. An upper therapeutic concentration limit is likely more than 15 ng/ml but a precise value could not be derived from these data.
Clinical Guide for Audiologic Tinnitus Management II (2005)

Purpose: This article is the second of 2 that address the need for basic procedures that can be used commonly by audiologists to manage patients with clinically significant tinnitus, as well as hyperacusis. The method described is termed audiologic tinnitus management (ATM). Method: ATM was developed specifically for use by audiologists. Although certain procedural components were adapted from the methods of tinnitus masking and tinnitus retraining therapy, ATM is uniquely and specifically defined. A detailed description of the ATM assessment procedures is provided in the companion article (J. A. Henry, T. L. Zaugg, &amp; M. A. Schechter, 2005). The present article describes a specific clinical protocol for providing treatment with ATM. Results: The treatment method described for ATM includes structured informational counseling and an individualized program of sound enhancement that can include the use of hearing aids, ear-level noise generators, combination instruments (noise generator and hearing aid combined), personal listening devices (wearable CD, tape, and MP3 players), and augmentative sound devices (e.g., tabletop sound generators). Ongoing treatment appointments involve primarily the structured counseling, evaluation, and adjustment of the use of sound devices, and assessment of treatment outcomes. The informational counseling protocol and an interview form for determining treatment outcomes are each described in step-by-step detail for direct clinical application. Conclusion: This article can serve as a practical clinical guide for audiologists to provide treatment for tinnitus in a uniform manner.
Nonenzymatic Transamination of Phenylglycine with 2-Oxoglutaric Acid Mediated by a Micellar Pyridoxal Model (1988)

Abstract Phenylglycine undergoes transamination with 2-oxoglutaric acid in the presence of N-dodecylpyridoxal chloride (DPL) and hexadecyltrimethylammonium chloride (CTACl) under mild conditions. This is the first example of nonenzymatic overall transamination realized in the absence of metal ions.
DtnSim: Bridging the Gap Between Simulation and Implementation of Space-Terrestrial DTNs (2017)

International audience
Incidental non-Hodgkin’s lymphoma in patients with localized prostate cancer (1999)

Patients with organ-confined prostate cancer, who are candidates for radical prostatectomy, experience long-term prostate cancer-free survival in the face of incidentally diagnosed low-grade lymphoma. Because the management of most incidentally discovered low-grade lymphomas is expectant, patients discovered at surgery to have this clinical entity should not be denied radical prostatectomy.
Zola nataliste ou féministe? Pouvoir féminin et sexualités subversives dans Fécondité (2022)

Scholars have described the role of women in Zola's Fécondité (1899) as limited primarily to motherhood, citing Marianne's twelve births as the maternal model idealized by the novelist. However, the dossiers préparatoires reveal a different story. Zola describes in detail his many female characters whose intimate desires express their quest for sexual liberty and for control over their own bodies. Although some of the most subversive elements were softened as Zola composed his novel, one can still discern them in the final text. Does this self-censorship reflect Zola's moral judgment of women? Or is it simply a narrative strategy to integrate his scientific theories on population growth? This article's objective is to study the subtle hints that Zola leaves in the novel and which allow for alternative interpretations of his female characters and their sexuality. I shall argue that these hints demonstrate his tacit approval of such characters and their behaviors. (In French)
Numerical Study of Non-Circular Pillar Effect in 3D-NAND Flash Memory Cells (2019)

Two-dimensional (2D) Technology-Aided Computer Design (TCAD) simulation method is proposed for evaluation of program/erase/retention degradation of Three-dimensional (3D) NAND Flash memory induced by structure deformation. Incremental step-pulse program (PGM) and erase (ERS) electrical characteristics are calculated for various spike-like deformations of vertical channel etch hole, including magnitude, width and amount. Strong dependence of erase speed and negative charge retention on spike deformation is found.
Computerised method to measure asymetrical articular compression on digitised X-rays (1998)

peer reviewed
PRE-10 DESIGN AND FABRICATION ON A NOVEL TRAVELING WAVE TYPE CYLINDRICAL ULTRASONIC LINEAR MICROACTUATOR(MM/Micro/Nano Precision Equipments IV,Technical Program of Oral Presentations) (2009)

A piezoelectric ultrasonic microactuator is presented, with a cylindrical stator and slider structure. The length and diameter of the microactuator are about 10 and 1.5 mm, respectively. The stator consists of two piezoelectric ceramic (PZT) tubes connected by a thin film metallic glass (TFMG) pipe, which is fabricated using the rotating magnetron sputtering technique. Traveling wave propagation is generated on the TFMG pipe in finite element method (FEM) simulations. Bi-directional motion of the slider was observed successfully around 600 kHz, and the maximum velocity was about 40 mm/s at 25 V.
Investigation of physical processes limiting plasma density in high confinement mode discharges on DIII-D (1997)

A series of experiments was conducted on the DIII-D tokamak [J. L. Luxon and L. G. Davis, Fusion Technol. 8, 441 (1985)] to investigate the physical processes which limit density in high confinement mode (H-mode) discharges. The typical H-mode to low confinement mode (L-mode) transition limit at high density near the empirical Greenwald density limit [M. Greenwald et al., Nucl. Fusion 28, 2199 (1988)] was avoided by divertor pumping, which reduced divertor neutral pressure and prevented formation of a high density, intense radiation zone (MARFE) near the X-point. It was determined that the density decay time after pellet injection was independent of density relative to the Greenwald limit and increased nonlinearly with the plasma current. Magnetohydrodynamic (MHD) activity in pellet-fueled plasmas was observed at all power levels, and often caused unacceptable confinement degradation, except when the neutral beam injected (NBI) power was ⩽3 MW. Formation of MARFEs on closed field lines was avoided with low safety factor (q) operation but was observed at high q, qualitatively consistent with theory. By using pellet fueling and optimizing discharge parameters to avoid each of these limits, an operational space was accessed in which density ∼1.5×Greenwald limit was achieved for 600 ms, and good H-mode confinement was maintained for 300 ms of the density flat-top. More significantly, the density was successfully increased to the limit where a central radiative collapse was observed, the most fundamental density limit in tokamaks.
Open-loop dynamic and static characteristics of the carotid sinus baroreflex in rats with chronic heart failure after myocardial infarction (2010)

We estimated open-loop dynamic characteristics of the carotid sinus baroreflex in normal control rats and chronic heart failure (CHF) rats after myocardial infarction. First, the neural arc transfer function from carotid sinus pressure to splanchnic sympathetic nerve activity (SNA) and its corresponding step response were examined. Although the steady-state response was attenuated in CHF, the negative peak response and the time to peak did not change significantly, suggesting preserved neural arc dynamic characteristics. Next, the peripheral arc transfer function from SNA to arterial pressure (AP) and its corresponding step response were examined. The steady-state response and the initial slope were reduced in CHF, suggesting impaired end-organ responses. In a simulation study based on the dynamic and static characteristics, the percent recovery of AP was reduced progressively as the size of disturbance increased in CHF, suggesting that a reserve for AP buffering is lost in CHF despite relatively maintained baseline AP.
Interferon-γ-induced MD-2 Protein Expression and Lipopolysaccharide (LPS) Responsiveness in Corneal Epithelial Cells Is Mediated by Janus Tyrosine Kinase-2 Activation and Direct Binding of STAT1 Protein to the MD-2 Promoter (2011)

The inability of epithelial cells from the cornea and other tissues to respond to LPS is reportedly due to low expression of the TLR4 co-receptor MD-2. We generated MD-2(-/-) bone marrow chimeras, and showed that MD-2 expression on non-myeloid cells was sufficient to mediate LPS-induced corneal inflammation. As IFN-γ is produced during Pseudomonas aeruginosa corneal infection, we examined the role of this cytokine on MD-2 expression by primary human corneal epithelial (HCE) cells and HCE cell lines. Exogenous IFN-γ was found to induce MD-2 mRNA, MD-2 cell surface expression, and LPS responsiveness as determined by p65 translocation to the nucleus and production of IL-6, CXCL1, and CXCL8/IL-8. Incubation with either the AG490 JAK2 inhibitor or with STAT1 siRNA blocked STAT1 phosphorylation and MD-2 transcription. Furthermore, EMSA analysis demonstrated that STAT1 binds to the MD-2 promoter, indicating that STAT1 is an MD-2 transcription factor. Together, these findings demonstrate that IFN-γ induces MD-2 expression and LPS responsiveness in HCE cells by JAK-2-dependent STAT1 activation and direct binding to the MD-2 promoter. Furthermore, given our findings on LPS-induced corneal inflammation, it is likely that IFN-γ-induced MD-2 expression by corneal epithelial cells contributes to the host response in vivo, determining the extent of tissue damage and bacterial clearance.
Oscillations of the crystalline lens in the human eye (2017)

As an active dynamic system, the eye continuously gains and releases kinetic energy to the ocular walls. The lens, however, is not rigidly attached to the walls (the zonular ligaments join the lens capsule to the ciliary muscle) and therefore, inertial oscillations of the lens are expected after every eye movement (saccades). By studying these oscillations, we obtain information on the functionality of the ciliary muscle and the mechanisms driving presbyopia. In particular, we demonstrate how the ciliary muscle is still able to contract during presbyopia and even keep functionality at more advanced ages (~80 years old). These results might stimulate the search for future intraocular devices making use of that remaining muscular force in the ageing eye.
Identification of a herpes simplex virus 1 gene encoding neurovirulence factor by chemical proteomics (2020)

Identification of the complete set of translated genes of viruses is important to understand viral replication and pathogenesis as well as for therapeutic approaches to control viral infection. Here, we use chemical proteomics, integrating bio-orthogonal non-canonical amino acid tagging and high-resolution mass spectrometry, to characterize the newly synthesized herpes simplex virus 1 (HSV-1) proteome in infected cells. In these infected cells, host cellular protein synthesis is shut-off, increasing the chance to preferentially detect viral proteomes. We identify nine previously cryptic orphan protein coding sequences whose translated products are expressed in HSV-1-infected cells. Functional characterization of one identified protein, designated piUL49, shows that it is critical for HSV-1 neurovirulence in vivo by regulating the activity of virally encoded dUTPase, a key enzyme that maintains accurate DNA replication. Our results demonstrate that cryptic orphan protein coding genes of HSV-1, and probably other large DNA viruses, remain to be identified.