gebhart/patrepeval huggingface dataset:
Epitope analysis of HLA‐DR‐restricted helper T‐cell responses to <i>Der p</i> II, a major allergen molecule of <i>Dermatophagoides pteronyssinus</i> (1996)

T-cell epitopes of Der p II, a major allergen of Dermatophagoides pteronyssinus, were analyzed by using human T-cell clones. We tested 38 cloned T cells from two Japanese patients with allergic rhinitis, and identified at least two peptides (K33-T47 and I58-C73) as helper T-cell epitopes. The former epitope was shown to be restricted by HLA-DRB1*1502, and the latter by HLA-DRB1*0405, both of which are typical Japanese HLA-DR alleles, suggesting that those T-cell epitopes might be important for the onset of house-dust mite allergy in the Japanese population. We prepared 15 analog peptides of the HLA- DRB1*1502-restricted 15-mer peptide. Of those 15 residues, five (F35, L37, A39, F41, and E42) were critical for the epitope activity, and three residues (F35, A39, and E42) seemed to be included in anchor motifs for HLA-DRB1*1502. The epitope peptide was also recognized by HLA-DRB1*1502-positive healthy donors; however, only allergic T cells showed Th2 functions. Antigen-presenting cells of nonallergic donors were able to activate allergic T cells to express Th2 function. This seemed to suggest that antigen recognition of T cells, as well as additional unknown factors which promote Th2, rather than Th1, responses, might be important for the onset of house-dust mite allergy.
Reduced Order Modeling of Aeroacoustic Systems for Stability Analyses of Thermoacoustically Non-Compact Gas Turbine Combustors (2015)

A methodology is presented to model non-compact thermoacoustic phenomena using Reduced Order Models (ROM) based on the Linearized Navier-Stokes Equations (LNSE). The method is applicable to geometries with a complex flow field as in a gas turbine combustion chamber. The LNSE, and thus the resulting ROM, include coupling effects between acoustics and mean fluid flow, and are hence capable of describing propagation and (e.g. vortical) damping of the acoustic fluctuations within the considered volume. Such a ROM then constitutes the main building block for a novel thermoacoustic stability analysis method via a low-order hybrid approach. This method presents an expansion to state-of-the-art low-order stability tools, and is conceptually based on three core features: Firstly, the multi-dimensional and volumetric nature of the ROM establishes access to account spatial variability and non-compact effects on heat release fluctuations. As a result, it is particularly useful for high frequency phenomena such as screech. Secondly, the LNSE basis grants the ROM the capability to reconstruct complex acoustic performances physically accurate. Thirdly, the formulation of the ROM in state-space allows convenient access to the frequency and time domain. In the time domain, non-linear saturation mechanisms can be included, which reproduce the non-linear stochastic limit cycle behavior of thermoacoustic oscillations. In order to demonstrate and verify the ROM’s underlying methodology, a test case using an orifice-tube geometry as the acoustic volume is performed. The generation of the ROM of the orifice-tube is conducted in a two-step procedure. As the first step, the geometrical domain is aeroacoustically characterized through the LNSE in frequency domain, and discretized via the Finite Element Method (FEM). The second step concerns the actual derivation of the ROM. The high-order dynamical system from the LNSE discretization is subjected to a modal reduction as order reduction technique. Mathematically, this modal reduction is the projection of the high-order (N ∼200,000) system into its truncated left eigenspace. An order reduction of several magnitudes (ROM order: Nr ∼100) is achieved. The resulting ROM contains all essential information about propagation and damping of the acoustic variables, and efficiently reproduces the aeroacoustic performance of the orifice-tube. Validation is achieved by comparing ROM results against numerical and experimental benchmarks from LNSE-FEM simulations and test rig measurements, respectively. Excellent agreement is found, which grants the ROM modeling approach full eligibility for further usage in the context of thermoacoustic stability modeling. This work is concluded by a methodological demonstration of performing stability analyses of non-compact thermoacoustic systems using the herein presented ROMs.
Nickel-Free Hydrogen Sulfide Control Technology for European Applications (1993)

&lt;div class="htmlview paragraph"&gt;In the USA, hydrogen sulfide emissions from three-way catalytic converter-equipped automobiles are effectively suppressed by the addition of nickel to catalyst formulations. This approach is generally not utilized in catalyst formulations for Europe because of European concern about the health, safety and environmental issues surrounding the use of nickel. A modified form of iron oxide has been identified which suppresses hydrogen sulfide emissions from three-way catalysts. This suppression has been achieved without affecting the fresh or aged performance of the catalyst, a problem often encountered with other materials. The performance and durability of catalyst formulations incorporating the new material are demonstrated with a variety of aging and evaluation protocols.&lt;/div&gt;
Overcoming Drug-Resistant Cancer by a Newly Developed Copper Chelate through Host-Protective Cytokine-Mediated Apoptosis (2006)

Our results show the potential usefulness of CuNG in immunotherapy of drug-resistant cancers irrespective of multidrug resistance phenotype.
(Invited) Ion Clusters and Li Transport in [Pyr<sub>12O1</sub>][FTFSI] Ionic Liquid-Based Electrolytes (2018)

The use of highly concentrated, binary ionic liquid/Li salt electrolytes with the novel asymmetric anion FTFSI results in improved rate capability and capacity retention at 20°C, as compared to Li + -diluted systems, in Li-metal and Li-ion cells [1]. This work explores the connection between the bulk electrolyte properties and the molecular organization to give insight into the concentration dependence of the Li + transport mechanisms. Below 30 mol%, the Li + -containing species are primarily smaller complexes (one Li + cation) and the Li + ion transport is mostly derived from the vehicular transport. Above 30%, where the viscosity is substantially higher and the conductivity lower, the Li + -containing species are a mix of small and large complexes (one and more than one Li + cation, respectively). The overall conduction mechanism likely changes to favor structural diffusion via the exchange of anions in the first Li + solvation shell [2]. The good rate performance is likely directly influenced by the presence of the larger Li + complexes, which promote Li + -ion transport (as opposed to Li + -complex transport) and increase the Li + availability at the electrode. In fact, electrophoretic NMR shows that Li is predominantly migrating in negatively charged Li-anion clusters towards the anode. However, this vehicular transport mechanism has decreasing relevance at elevated Li + concentrations. References G. A. Giffin, A. Moretti, S. Jeong and S. Passerini, J. Power Sources , 2017, 342 , 335-341. G. A. Giffin, A. Moretti, S. Jeong, K. Pilar, M. Brinkkötter, S. G. Greenbaum, M. Schönhoff and S. Passerini, ChemSusChem , 2018, doi:10.1002/cssc.201702288. M. Brinkkötter, G. A. Giffin, A. Moretti, S. Jeong, S. Passerini and M Schönhoff, Chem Comm , 2018, submitted for publication
Novel spiro-based hole transporting materials for efficient perovskite solar cells (2015)

Three spiro-acridine-fluorene based hole transporting materials (HTMs), namely CW3, CW4 and CW5, are employed in the fabrication of organic-inorganic hybrid perovskite solar cells. The corresponding mesoscopic TiO2/CH3NH3PbI3/HTM devices are investigated and compared with that made with commercial spiro-OMeTAD. The best conversion efficiency of 16.56% is achieved for CW4 in the presence of tBp and Li-TFSI as additives and without a cobalt dopant. The performances of CW4 are further examined in terms of conductivity, mobility, morphology, and stability to show its potential as an alternative HTM.
Large-scale identification of extracellular plant miRNAs in mammals implicates their dietary intake (2021)

Extracellular microRNAs (miRNAs) have been proposed to function in cross-kingdom gene regulation. Among these, plant-derived miRNAs of dietary origin have been reported to survive the harsh conditions of the human digestive system, enter the circulatory system, and regulate gene expression and metabolic function. However, definitive evidence supporting the presence of plant-derived miRNAs of dietary origin in mammals has been difficult to obtain due to limited sample sizes. We have developed a bioinformatics pipeline (ePmiRNA_finder) that provides strident miRNA classification and applied it to analyze 421 small RNA sequencing data sets from 10 types of human body fluids and tissues and comparative samples from carnivores and herbivores. A total of 35 miRNAs were identified that map to plants typically found in the human diet and these miRNAs were found in at least one human blood sample and their abundance was significantly different when compared to samples from human microbiome or cow. The plant-derived miRNA profiles were body fluid/tissue-specific and highly abundant in the brain and the breast milk samples, indicating selective absorption and/or the ability to be transported across tissue/organ barriers. Our data provide conclusive evidence for the presence of plant-derived miRNAs as a consequence of dietary intake and their cross-kingdom regulatory function within human circulating system.
Dual-chamber pacemaker implantation with left ventricular pacing in a patient with a right ventricular assist device (2014)

A 63-year-old patient developed right ventricular failure and intermittent complete heart block after an acute dissection of the right coronary artery. An emergency bypass surgery did not prevent right heart failure. Initially bridged with an extracorporeal membrane oxygenation, a HeartWare® …
Visual explanation of evidence in additive classifiers (2006)

Machine-learned classifiers are important components of many data mining and knowledge discovery systems. In several application domains, an explanation of the classifier&amp;apos;s reasoning is critical for the classifier’s acceptance by the end-user. We describe a framework, ExplainD, for explaining decisions made by classifiers that use additive evidence. ExplainD applies to many widely used classifiers, including linear discriminants and many additive models. We demonstrate our ExplainD framework using implementations of naïve Bayes, linear support vector machine, and logistic regression classifiers on example applications. ExplainD uses a simple graphical explanation of the classification process to provide visualizations of the classifier decisions, visualization of the evidence for those decisions, the capability to speculate on the effect of changes to the data, and the capability, wherever possible, to drill down and audit the source of the evidence. We demonstrate the effectiveness of ExplainD in the context of a deployed web-based system (Proteome Analyst) and using a downloadable Python-based implementation.
Frustrated Lewis Pairs and Ring-Opening of THF, Dioxane, and Thioxane (2010)

The reaction of tBu2PH and B(p-C6F4H)3 in THF afforded tBu2(H)P(CH2)4OB(p-C6F4H)3 (1). Similarly, reactions of N-bases with a THF solution of B(C6F5)3 led to the formation of the THF-ring-opening products C5H3Me2N(CH2)4OB(C6F5)3 (2), C6H5CH2NMe2(CH2)4OB(C6F5)3 (3), and Me2NC6H4NMe2(CH2)4OB(C6F5)3 (4). THF-ring-opening also occurs with aliphatic amines to form the compounds Me3N(CH2)4OB(C6F5)3 (5), Et3N(CH2)4OB(C6F5)3 (6), Me2N(CH2)2NMe2(CH2)4OB(C6F5)3 (7), and tBuHN(CH2)2NHtBu(CH2)4OB(C6F5)3 (8). In related chemistry, reactions of B(C6F5)3, 1,4-dioxane, and the appropriate base yielded tBu3P(CH2)2O(CH2)2OB(C6F5)3 (10), C6H5CH2NMe2(CH2)2O(CH2)2OB(C6F5)3 (11), ((tBuN)2C3H2)(CH2)2O(CH2)2OB(C6F5)3 (12), Me2NC6H4NMe2(CH2)2O(CH2)2OB(C6F5)3 (13), and C5H3Me2N(CH2)2O(CH2)2OB(C6F5)3 (14). In a related fashion, the thioxane adduct (C6F5)3B(SC4H8O) (15) reacted with N,N-dimethylbenzylamine, N,N,N′,N′-tetramethyl-p-phenylenediamine, 2,6-lutidine, or tBu3P to give the corresponding ring-opened products L(CH2)2S(CH2)2OB(C6F5)3 (L = tBu3P (16), C6H5CH2NMe2 (17), Me2NC6H4NMe2 (18), and C5H3Me2N (19)). The crystal structures of 1−7, 10−12, 14, 18, and 19 are reported.
ChemInform Abstract: USE OF ORGANOCUPRATES IN AMINO ACID SYNTHESIS (1983)

Abstract Aus den Iodiden (I) erhält man mit Cupraten (II) die substituierten Aminosäurederivate (III).
Diode-pumped laser action and self-frequency doubling in Nd<sup>3+</sup>:YCOB (1999)

Development of the oxyborate Nd<SUP>3+</SUP>:YCOB has brought about the realization of single crystal elements under diode pumped operation for compact simple, solid state lasers producing visible laser emission. Efficient laser action and self-frequency doubling (SFD) has been obtained for both Ti:Sapphire and diode pumped operations. Comparable results were obtained for a hemispherical linear cavity with a 2% output coupler for fundamental operation. The fundamental output power of the Nd:YCOB under Ti:Sapphire pumping was in excess of 400 mW with a slope efficiency of 44% with approximately 1 W absorbed. Utilizing high brightness laser diodes, over 350 mW of fundamental output power has been obtained with a slope efficiency of 51% for similar absorbed powers. Efficient SFD operation was demonstrated in both pumping modes with no output coupling at the fundamental wavelength and high transmission of the second harmonic using a 5% doped Nd:YCOB crystal. Output powers of approximately 60 mW at 530 nm were obtained with both Ti:Sapphire and laser diode pumping.
The Identification and Evolutionary Trends of the Solute Carrier Superfamily in Arthropods (2020)

The solute carrier (SLC) transporter superfamily comprises an ancient and ubiquitous group of proteins capable of translocating a range of nutrients, endogenous molecules, and xenobiotics. Although the group has been the subject of intense investigation in both bacteria and mammals, its systematic identification in arthropods has not yet been undertaken. Here, we present a genome-wide identification of all 66 human SLC families in 174 arthropod species. A pipeline (SLC_id) was constructed to identify and group SLCs using a combination of hidden Markov model and BLAST searches followed by filtering based on polypeptide length and the number of transmembrane domains. Comparative analysis of the number of transporters in each family across diverse arthropod lineages was accomplished using one-way analysis of variance (ANOVA) and the Computational Analysis of gene Family Evolution (CAFE). These results suggested that many SLC families have undergone expansions or contractions in particular evolutionary lineages. Notably, the sugar transporting SLC2 family was significantly larger in insects compared with arachnids. This difference may have been complemented by a rapid expansion of the SLC60 family in arachnids which also acts on dietary sugars. Furthermore, the SLC33 family underwent a recent and drastic expansion in aphids, although the biological relevance of this expansion was not possible to infer. Information on specific SLC transporter families across arthropod species can be accessed through an R shiny web application at http://chrysalida.imbb.forth.gr : 3838/Arthropod_SLC_Database/. The present study greatly facilitates further investigation of the diverse group of SLC transporters in arthropods.
On the effect of pion condensates on the spectrum of neutron stars (2016)

There is no precise theory describing the structure of neutron stars. However, inside such objects the baryon density is very high and a pion condensation may occur. These condensates, if they exist, might give a significant effect on a spectrum of neutron stars. We investigate this influence with a help of simplified model to give qualitative picture of the effect.
Simultaneous Optimization of Speed Profile and Allocation of Wireless Power Transfer System for Autonomous Driving Electric Vehicles (2018)

Optimal allocation of wireless power transfer system (WPTSys) for electric vehicles (EVs) plays an important role in reducing the manufacturing costs of WPTSys. In the conventional approach, the allocation of WPTSys requires information on EV operation such as speed profile and power demand. This paper proposes a new methodology based on mathematical optimization for the simultaneous design of EV speed profile and allocation of WPTSys in a lane segment, with the aim of reducing the cost of WPTSys by minimizing its length. By parameterizing both EV operation and allocation of WPTSys as unknown parameters, an optimization problem with constraints of EV operation and battery sustainability is established for optimizing these unknown parameters to minimize the length of WPTSys. Therefore, the optimal speed profile of EV and optimal allocation of WPTSys can be simultaneously determined. The proposed approach is applied to a scenario of autonomous driving EVs, where it is assumed that the designed speed profile is accurately tracked. A numerical case study is conducted to illustrate the proposed approach. Furthermore, it is shown that our proposed method achieves WPT systems that are shorter in length compared to those obtained using the conventional method under the same operational constraints of EV and battery.
Proton Beam Therapy in Elderly Patients With cT1-3N0M0 Non-small Cell Lung Cancer (2022)

PBT may be a reasonable approach for treating lung cancer in elderly patients with T1-3N0M0 NSCLC.
Simultaneous determination of aconite alkaloids and ginsenosides using online solid phase extraction hyphenated with polarity switching ultra-high performance liquid chromatography coupled with tandem mass spectrometry (2014)

Simultaneous determination of ten aconite alkaloids and thirteen ginsenosides using online solid phase extraction hyphenated with polarity switching ultra-high performance liquid chromatography coupled with tandem mass spectrometry.
Face classification with support vector machine (2004)

A new approach to feature based frontal face recognition with Gabor wavelets and support vector machines is presented in this paper. The feature points are automatically extracted using the local characteristics of each individual face. A kernel that computes the similarity between two feature vectors, is used to map the face features to a space with higher dimension. To find the identity of a test face, the possible labels of each feature vector of that face is found with support vector machines, then the last decision is made by considering all of those labels. By using Gabor features the number of support vectors is reduced compared to directly using the actual image data, and also a better generalization performance is achieved.
Überlagerung fertigungsbedingter Inhomogenitäten und beschleunigter Alterung bei Silikonklebstoffen (2023)

Die Bemessung von Structural-Glazing-Konstruktionen erfolgt in Deutschland unter Verwendung hoher „Sicherheitsfaktoren“ (ETAG 002). Im dort vorgeschlagenen globalen Sicherheitsfaktor von sechs gehen diverse die Klebstofffestigkeit mindernde Einflüsse ein. Der Anteil dieser Einflüsse an diesem pauschalisierten Faktor ist jedoch nicht näher beschrieben. Im Rahmen dieses Beitrags wird der Einfluss verschiedener fertigungsbedingter Inhomogenitäten sowie der Einfluss und die teilweise Überlagerung beschleunigter Alterungsverfahren auf das Materialverhalten von zugelassenen Silikonklebstoffen untersucht. Es wird ein Ausblick auf ein alternatives Bemessungskonzept gegeben, welches auf dem semiprobabilistischen Teilsicherheitskonzept nach Eurocode basiert. Superposition of manufacturing-related inhomogeneities and accelerated aging of silicone adhesives . In Germany, structural glazing is designed using high "safety factors" (ETAG 002). The global safety factor of six proposed there includes various influences that reduce the adhesive strength. However, the share of these influences in this generalized factor is not described in detail. In this paper, the influence of different manufacturing-related inhomogeneities and the influence and partial superposition of accelerated aging processes on the material behaviour of approved silicone adhesives are investigated. An outlook on an alternative design concept is given, which is based on the semi-probabilistic partial safety concept according to Eurocode.
Synthesis and in Vitro Evaluation of a Rhenium-Cyclized Somatostatin Derivative Series (2008)

The structure-activity relationships of a series of rhenium (Re)-cyclized octreotide derivatives are described. The effects of changes in the peptide sequence, N-terminus, and C-terminus on metal cyclization, as well as binding to the somatostatin receptor, were investigated. Each peptide complex was found to have an integrated Re(V) core with a single metal oxo group, two coordination sites filled by the cysteine sulfhydryls, and another by the amide nitrogen of Phe (3)/Tyr (3). The final coordination site was determined by the peptide N-terminus: the N-terminal amine coordinated for N-NH 2 peptides and the amide nitrogen of Thr (6) for peptides with acetylated N-termini. Re-cyclization of the octreotide derivatives led to structural perturbations of the somatostatin receptor-binding sequence relative to the Re-free disulfide analogues, resulting in reduced binding affinities. The findings presented herein demonstrate the importance of understanding the consequences of structural modifications when designing metal-peptide complexes for somatostatin receptor targeting.
A study of supervisory constraints in a class of coordinated multiagent systems (2004)

We present a class of supervisory multiagent sys- tems in which each agent is based on an enhanced form of the intelligent agent paradigm called the Hybrid Intelligent Control Agent (HICA). A bound on supervisory input event rates neces- sary to preserve multiagent stability is obtained and studied in a pursuit-evasion simulation involving multiple autonomous un- manned vehicles.
DFT Study of Internal Alkyne-to-Disubstituted Vinylidene Isomerization in [CpRu(PhC≡CAr)(dppe)]<sup>+</sup> (2012)

Internal alkyne-to-vinylidene isomerization in the Ru complexes ([CpRu(η(2)-PhC≡CC(6)H(4)R-p)(dppe)](+) (Cp = η(5)-C(5)H(5); dppe = Ph(2)PCH(2)CH(2)PPh(2); R = OMe, Cl, CO(2)Et)) has been investigated using a combination of quantum mechanics and molecular mechanics methods (QM/MM), such as ONIOM(B3PW91:UFF), and density functional theory (DFT) calculations. Three kinds of model systems (I-III), each having a different QM region for the ONIOM method, revealed that considering both the quantum effect of the substituent of the aryl group in the η(2)-alkyne ligand and that of the phenyl groups in the dppe ligand is essential for a correct understanding of this reaction. Several plausible mechanisms have been analyzed by using DFT calculations with the B3PW91 functional. It was found that the isomerization of three complexes (R = OMe, CO(2)Et, and Cl) proceeds via a direct 1,2-shift in all cases. The most favorable process in energy was path 3, which involves the orientation change of the alkyne ligand in the transition state. The activation energies were calculated to be 13.7, 15.0, and 16.4 kcal/mol, respectively, for the three complexes. Donor-acceptor analysis demonstrated that the aryl 1,2-shift is a nucleophilic reaction. Furthermore, our calculation results indicated that an electron-donating substituent on the aryl group stabilizes the positive charge on the accepting carbon rather than that on the migrating aryl group itself at the transition state. Therefore, unlike the general nucleophilic reaction, the less-electron-donating aryl group has an advantage in the migration.