gebhart/patrepeval huggingface dataset:
Etude de la structure des vortex dans bi2212 par des mesures de dissipation hyperfrequence (1997)

Des structures de vortex specifiques aux supraconducteurs lamellaires avec couplage josephson, tres differentes de celle des vortex abrikosov, sont predites par la theorie. Dans le but d'etudier ces structures dans bi2212, nous avons effectue des mesures de dissipation hyperfrequence a 10ghz. A cette frequence, nous decouplons l'analyse de la structure des vortex de celle des mecanismes de leur dissipation. C'est la mise en evidence de regimes de dissipation differents qui nous permet de caracteriser des structures differentes de vortex : les vortex josephson, verrouilles, evoluent vers une structure de vortex inclines, constitues d'un empilement de vortex 2d (transition de deverrouillage en presence d'un champ incline). Nous avons etabli l'existence de la structure intermediaire de vortex en escalier. Nous mesurons deux champs de penetration, celui de la composante parallele, puis celui de la composante perpendiculaire, en fonction de la temperature. Nous deduisons une valeur de l'anisotropie = 400. Nous avons etudie l'influence de defauts colonnaires paralleles a c sur la transition de deverrouillage. Nous abordons enfin l'analyse des mecanismes de dissipation, dans les differents regimes mis en evidence. Deux d'entre eux reposent sur l'action de la force de lorentz, tandis qu'un troisieme regime, non conventionnel, est relie au decouplage des couches sous l'effet des fluctuations thermiques.
High c-Myb Expression Associates with Good Prognosis in Colorectal Carcinoma (2019)

Colorectal cancer (CRC) represents a serious challenge for oncologists due to high incidence and large heterogeneity. Prognostic factors are needed to stratify patients according to risk of disease progression. In this study, we report that high expression of c-Myb protein, determined by immunohistochemistry (IHC), associates with better overall and disease-free survival (OS, DFS) in a cohort of 103 patients. Although <i>MYB</i> has been previously considered to act as oncogene in CRC, our further analysis of datasets deposited in PrognoScan and SurvExpress databases confirmed that high <i>MYB</i> expression largely associates with good prognosis in CRC. As therapies targeting c-Myb have been developed and tested in preclinical studies, we believe that further studies are needed for detailed understanding of c-Myb function in CRC, before the c-Myb-targeted therapy enters clinical trials.
BIOL-07. MIR-212 FUNCTIONS AS A TUMOR SUPPRESSOR GENE IN GROUP 3 MEDULLOBLASTOMA VIA TARGETING NUCLEAR FACTOR I/B (NFIB) (2021)

Abstract Medulloblastoma (MB), the most frequent malignant pediatric brain tumor is subdivided into four primary subgroups, i.e. wingless-type (WNT), sonic hedgehog (SHH), group 3, and group 4. Haploinsufficiency of chromosome 17p13.3 and c-myc amplification distinguish high-risk group 3 tumors, which are associated with rapid metastasis, recurrence and early mortality. We sought to identify the role of miR-212, which resides on chromosome 17p13.3, in the pathophysiology of group 3 MB. RNA expression analyses revealed dramatically reduced levels of miR-212 in group 3 tumors and cell lines mainly through epigenetic silencing via histone modifications (deacetylation). Restoring in vitro miR-212 expression reduced tumor cell proliferation, colony formation, wound healing, migration and invasion with decreased p-AKT and p-ERK levels in group 3 MB cell lines. Interestingly, a shift in differential c-myc phosphorylation (from serine-62 to threonine-58) was also discovered with miR-212 expression, resulting in reduced total c-myc levels, concurrent with elevated cellular apoptosis. In turn, pro-apoptotic binding partners of c-myc, i.e. Bin-1 and P19ARF, were upregulated in these cells. These findings were recapitulated in stable inducible miR-212 expressing tumor cells. Using a combination of transcriptomic data and a dual luciferase assay, we isolated an important oncogenic target of miR-212, i.e, NFIB, a nuclear transcription factor implicated in metastasis and recurrence. Increased expression of NFIB was confirmed in group 3 tumors, with poor survival shown in high NFIB-expressing patients. As prior, transient NFIB silencing in vitro reduced not only tumor cell proliferation, colony formation, wound healing, migration and invasion, but also medullosphere formation along with decreased expression of stem cell markers (Nanog, Oct4, Sox2, CD133), confirming its role in tumor recurrence possibly via augmenting tumor stemness. Taken together, these results substantiate the tumor suppressive role of miR-212 in group 3 MB and provide a potential new oncogenic target implicated in tumor recurrence, NFIB.
Staurosporines Disrupt Phosphatidylserine Trafficking and Mislocalize Ras Proteins (2012)

Oncogenic mutant Ras is frequently expressed in human cancers, but no anti-Ras drugs have been developed. Since membrane association is essential for Ras biological activity, we developed a high content assay for inhibitors of Ras plasma membrane localization. We discovered that staurosporine and analogs potently inhibit Ras plasma membrane binding by blocking endosomal recycling of phosphatidylserine, resulting in redistribution of phosphatidylserine from plasma membrane to endomembrane. Staurosporines are more active against K-Ras than H-Ras. K-Ras is displaced to endosomes and undergoes proteasomal-independent degradation, whereas H-Ras redistributes to the Golgi and is not degraded. K-Ras nanoclustering on the plasma membrane is also inhibited. Ras mislocalization does not correlate with protein kinase C inhibition or induction of apoptosis. Staurosporines selectively abrogate K-Ras signaling and proliferation of K-Ras-transformed cells. These results identify staurosporines as novel inhibitors of phosphatidylserine trafficking, yield new insights into the role of phosphatidylserine and electrostatics in Ras plasma membrane targeting, and validate a new target for anti-Ras therapeutics.
Hemicellulose hydrolysis catalysed by solid acids (2013)

Depolymerising hemicellulose into platform sugar molecules is a key step in developing the concept of an integrated biorefinery. This reaction is traditionally catalysed by either enzymes or homogeneous mineral acids. We compared various solid catalysts for hemicellulose hydrolysis, running reactions in water, under neutral pH and relatively mild temperature and pressure (120 °C and 10 bar) conditions. Sulphonated resins are highly active, but they leach out sulphonic groups. Sulphonated silicas are less active, but more stable. They have weakly and strongly bound sites and the strongly bound ones do not leach. Zeolites are moderately active and stable. Among them, H-ferrierite especially, despite its small pores, exhibited high activity as well as good recyclability.
Heuristic Screening Methodology for Regional Wastewater‐Treatment Planning (1993)

A simple and efficient heuristic screening methodology is presented for use in the regional planning of wastewater‐treatment systems. The proposed approach provides a powerful tool to aid practicing engineers in the decision‐making process regarding optimal locations of regional wastewater collection and treatment facilities. The criterion for eliminating nonoptimal treatment‐plant sites for every wastewater source in the region considered is the critical distance parameter. This nonoptimality conditional parameter is derived from the interrelation between the lower bound on transportation cost and the upper bound on regionalization efficiency. The resulting method is able to significantly reduce the number of candidate locations of shared facilities for regionalized treatment. The final optimal solution may then be selected from the remaining attractive alternative plans by employing conventional mathematical programming precedures. One case example, taken from a previous paper, and four actual large‐scale problems are analyzed and discussed. Enhancement of regional systems management is a principal benefit of the proposed methodology.
The <b> <i>HMG-I</i> </b> Oncogene Causes Highly Penetrant, Aggressive Lymphoid Malignancy in Transgenic Mice and Is Overexpressed in Human Leukemia (2004)

HMG-I/Y is overexpressed in human cancer, although a direct role for this gene in transformation has not been established. We generated transgenic mice with HMG-I targeted to lymphoid cells. All seven informative founder HMG-I mice developed aggressive lymphoma by a mean age of 4.8 months. Tumors express T-cell markers and are transplantable. We also demonstrate that HMG-I mRNA and protein are increased in human acute lymphocytic leukemia samples. Our results show that HMG-I functions as an oncogene and suggest that it contributes to the pathogenesis of leukemia and other cancers with increased HMG-I expression.
The relaxation dynamics of the excited electronic states of retinal in bacteriorhodopsin by two-pump-probe femtosecond studies (2001)

We present the results of two-pump and probe femtosecond experiments designed to follow the relaxation dynamics of the lowest excited state (S(1)) populated by different modes. In the first mode, a direct (S(0) --> S(1)) radiative excitation of the ground state is used. In the second mode, an indirect excitation is used where the S(1) state is populated by the use of two femtosecond laser pulses with different colors and delay times between them. The first pulse excites the S(0) --> S(1) transition whereas the second pulse excites the S(1) --> S(n) transition. The nonradiative relaxation from the S(n) state populates the lowest excited state. Our results suggest that the S(1) state relaxes faster when populated nonradiatively from the S(n) state than when pumped directly by the S(0) --> S(1) excitation. Additionally, the S(n) --> S(1) nonradiative relaxation time is found to change by varying the delay time between the two pump pulses. The observed dependence of the lowest excited state population as well as its dependence on the delay between the two pump pulses are found to fit a kinetic model in which the S(n) state populates a different surface (called S'(1)) than the one being directly excited (S(1)). The possible involvement of the A(g) type states, the J intermediate, and the conical intersection leading to the S(0) or to the isomerization product (K intermediate) are discussed in the framework of the proposed model.
Prognostic and Predictive Factors in Patients with Advanced HCC and Elevated Alpha-Fetoprotein Treated with Ramucirumab in Two Randomized Phase III Trials (2022)

Ramucirumab provided a survival benefit irrespective of baseline prognostic covariates, and this benefit was greatest in patients with high ramucirumab drug exposure and/or those with treatment-related hypertension.
Characterisation of a PVCP based tissue-mimicking phantom for Quantitative Photoacoustic Imaging (2015)

Photoacoustic imaging can provide high resolution images of tissue structure, pathology and function. As these images can be obtained at multiple wavelengths, quantitatively accurate, spatially resolved, estimates for chromophore concentration, for example, may be obtainable. Such a capability would find a wide range of clinical and pre-clinical applications. However, despite a growing body of theoretical papers on how this might be achieved, there is a noticeable lack of studies providing validated evidence that it can be achieved experimentally, either in vitro or in vivo. Well-defined, versatile and stable phantom materials are essential to assess the accuracy, robustness and applicability of multispectral Quantitative Photoacoustic Imaging (qPAI) algorithms in experimental scenarios. This study assesses the potential of polyvinyl chloride plastisol (PVCP) as a phantom material for qPAI, building on previous work that focussed on using PVCP for quality control. Parameters that might be controlled or tuned to assess the performance of qPAI algorithms were studied: broadband acoustic properties, multiwavelength optical properties with added absorbers and scatterers, and photoacoustic efficiency.The optical and acoustic properties of PVCP can be tuned to be broadly representative of soft tissue. The Grüneisen parameter is larger than expected in tissue, which is an advantage as it increases the signal-to-noise ratio of the photoacoustic measurements. Interestingly, when the absorption was altered by adding absorbers, the absorption spectra measured using high peak power nanosecond-pulsed sources (typical in photoacoustics) were repeatably different from the ones measured using the low power source in the spectrophotometer, indicative of photochemical reactions taking place.
Investigating biofilm structure using x-ray microtomography and gratings-based phase contrast (2012)

Direct examination of natural and engineered environments has revealed that the majority of microorganisms in these systems live in structured communities termed biofilms. To gain a better understanding for how biofilms function and interact with their local environment, fundamental capabilities for enhanced visualization, compositional analysis, and functional characterization of biofilms are needed. For pore-scale and community-scale analysis (100’s of nm to 10’s of microns), a variety of surface tools are available. However, understanding biofilm structure in complex three-dimensional (3-D) environments is considerably more difficult. X-ray microtomography can reveal a biofilm’s internal structure, but obtaining sufficient contrast to image low atomic number (Z) biological material against a higher-Z substrate makes detecting biofilms difficult. Here we present results imaging Shewanella oneidensis biofilms on a Hollow-fiber Membrane Biofilm Reactor (HfMBR), using the x-ray microtomography system at sector 2-BM of the Advanced Photon Source (APS), at energies ranging from 12.9-15.4 keV and pixel sizes of 0.7 and 1.3 &mu;m/pixel. We examine the use of osmium (Os) as a contrast agent to enhance biofilm visibility and demonstrate that staining improves imaging of hydrated biofilms. We also present results using a Talbot interferometer to provide phase and scatter contrast information in addition to absorption. Talbot interferometry allows imaging of unstained hydrated biofilms with phase contrast, while absorption contrast primarily highlights edges and scatter contrast provides little information. However, the gratings used here limit the spatial resolution to no finer than 2 &mu;m, which hinders the ability to detect small features. Future studies at higher resolution or higher Talbot order for greater sensitivity to density variations may improve imaging.
Attentional orienting in virtual reality using endogenous and exogenous cues in auditory and visual modalities (2019)

The virtual reality (VR) has nowadays numerous applications in training, education, and rehabilitation. To efficiently present the immersive 3D stimuli, we need to understand how spatial attention is oriented in VR. The efficiency of different cues can be compared using the Posner paradigm. In this study, we designed an ecological environment where participants were presented with a modified version of the Posner cueing paradigm. Twenty subjects equipped with an eye-tracking system and VR HMD performed a sandwich preparation task. They were asked to assemble the ingredients which could be either endogenously and exogenously cued in both auditory and visual modalities. The results showed that all valid cues made participants react faster. While directional arrow (visual endogenous) and 3D sound (auditory exogenous) oriented attention globally to the entire cued hemifield, the vocal instruction (auditory endogenous) and object highlighting (visual exogenous) allowed more local orientation, in a specific region of space. No differences in gaze shift initiation nor time to fixate the target were found suggesting the covert orienting.
Terrain runner (2012)

In this paper we learn the skills required by real-time physics-based avatars to perform parkour-style fast terrain crossing using a mix of running, jumping, speed-vaulting, and drop-rolling. We begin with a single motion capture example of each skill and then learn reduced-order linear feedback control laws that provide robust execution of the motions during forward dynamic simulation. We then parameterize each skill with respect to the environment, such as the height of obstacles, or with respect to the task parameters, such as running speed and direction. We employ a continuation process to achieve the required parameterization of the motions and their affine feedback laws. The continuation method uses a predictor-corrector method based on radial basis functions. Lastly, we build control laws specific to the sequential composition of different skills, so that the simulated character can robustly transition to obstacle clearing maneuvers from running whenever obstacles are encountered. The learned transition skills work in tandem with a simple online step-based planning algorithm, and together they robustly guide the character to achieve a state that is well-suited for the chosen obstacle-clearing motion.
Structures of the heart specific SERCA2a Ca <sup>2+</sup> -ATPase (2018)

Abstract The isoform 2a of sarco/endoplasmic reticulum Ca 2+ -ATPase (SERCA2a) performs active reuptake of cytoplasmic Ca 2+ and is a major regulator of cardiac muscle contractility. Dysfunction or dysregulation of SERCA2a is associated with heart failure, while restoring its function is considered as a therapeutic strategy to restore cardiac performance, but its structure was not yet determined. Based on native, active protein purified from pig ventricular muscle, we present the first crystal structures of SERCA2a that were determined in the CPA-stabilized and H + -occluded [H 2-3 ]E2-AlF 4 - (3.3 Å) form, arranged as parallel dimers, and the Ca 2+ -occluded [Ca 2 ]E1-ATP (4.0 Å) form. We compare these new structures to similar forms of the skeletal muscle SERCA1a and address structural, functional and regulatory differences. We show that the isoform specific motifs of SERCA2a allow a distinct regulation by post-translational modifications and affect the dynamic behavior, which may explain specific properties and regulation.
Multi-layer conduction in epitaxial InSb grown on GaAs substrates (2002)

Electron transport properties of molecular beam epitaxy grown InSb on GaAs substrates are studied using the conventional Hall effect and the mobility spectrum technique. The latter technique reveals the existence of at least three different conducting channels in InSb. Our analysis of the Hall data and the mobility spectrum shows that the conduction in InSb is determined by a highly dislocated interfacial layer between the InSb layer and the GaAs substrate, a high mobility bulk-like InSb layer, and, possibly, a surface layer.
Evaluation des impacts du changement climatique dans les différents vignobles de France à l'aide du modèle STICS-vigne (2007)

Événement(s) lié(s) : - Congress on climate and viticulture; Zaragoza (Saragosse) (ESP) - (2007-04-10 - 2007-04-14)- Congreso sobre clima y viticultura; Zaragoza (Saragosse) (ESP) - (2007-04-10 - 2007-04-14)
Ultrasensitive hydrazine sensor fabrication based on Co-doped ZSM-5 zeolites for environmental safety (2017)

Various Co-loaded ZSM-5 zeolites (Co-ZSM-5) were prepared and the details of their structural, morphological and elemental properties characterized by different conventional methods.
Prospective, Comparative Evaluation of Three Laser Systems Used Individually and in Combination for Axillary Hair Removal (2005)

Background Using the concept of selective photothermolysis, a variety of laser systems have been developed to remove unwanted hair. Objective To evaluate the relative efficacy, tolerability, and subject satisfaction of three different laser systems used individually and in rotation for axillary hair removal. Methods Twenty female patients (17 with dark-colored hair, 3 with red or light-colored hair) with Fitzpatrick phototype II skin received three treatments performed at 6- to 8-week intervals. Each axilla was divided in half to yield four distinct areas that were treated by the following lasers: (1) three sessions with a long-pulse 755 nm alexandrite laser, (2) three sessions with a long-pulse 810 nm diode laser, (3) three sessions with a long-pulse 1,064 nm neodymium:yttrium-aluminum-garnet (Nd:YAG) laser, and (4) rotational treatment consisting of a single session by each of the three laser systems. Percent hair reduction and acute and long-term side effects were evaluated after treatment. Subjects completed questionnaires assessing tolerability and satisfaction. Results All subjects tolerated the treatments well, with only local, transient side effects seen. At the 3-month follow-up, the greatest average hair reduction was comparably similarly seen after the alexandrite laser at 59.3 ± 9.7% and the 810 nm diode laser at 58.7 ± 7.7%. The Nd:YAG laser and rotational regimens were less efficacious, with 31.9 ± 11.1% and 39.8 ± 10.1% hair reduction, respectively. Subjects with red or light-colored hair experienced 5 to 15% reduced efficacy with any laser system used. Subjects found the alexandrite and diode lasers to be equally tolerable, with only slight discomfort, and the Nd:YAG laser to be the least comfortable of the three systems. Overall, subject satisfaction of each treated site, in decreasing order, was (1) the 810 nm diode laser, (2) the alexandrite laser, (3) rotational therapy, and (4) the Nd:YAG laser. Conclusion At the 3-month follow-up, the long-pulse alexandrite and 810 nm diode lasers demonstrated no statistically significant differences in efficacy, comparable efficacy and tolerability, and highest subject satisfaction. Rotational therapy with the three laser systems is not as effective as treatment with the alexandrite laser or diode laser alone but is statistically more effective than use of the long-pulse Nd:YAG system alone. Individuals with red or light-colored hair and Fitzpatrick phototype II skin have decreased efficacy of laser treatment than those with dark-colored hair and the same phototype.
Some effects of diet on beef meat and fat attributes (1999)

Abstract Steers were fed for nine weeks on either ryegrass/clover pasture or maize (six animals per group), to evaluate the effects of diet on attributes of meat and fat. Feed intake was restricted in the grain‐fed group with the intention of producing equivalent growth rates in the two treatment groups, but this resulted in significantly slower weight gain, reduced carcass weight, and reduced subcutaneous and intramuscular fat. Nevertheless, the glycolytic potential (an estimate of pre‐slaughter glycogen) in the M. longissimus dorsi lumborum was approximately 20% higher ( P &lt; 0.05) in the grain‐fed cattle, while the ultimate pH of the meat was equivalent for both groups. The results suggest that grain‐based diets can increase muscle glycogen concentrations independent of the higher calorific intake normally associated with grain diets, probably in response to changes in rumen fatty acid production. Compared with grain diet, pasture diet resulted in significantly higher (P &lt; 0.01) muscle tocopherol content, but did not influence meat colour. The dietary treatments influenced fat colour, but both carotene content and energy intake may be responsible for this effect. The microbiological profile of meat during chilled storage was not affected by diet.