gebhart/patrepeval huggingface dataset:
Sequence variations in the <i>TIGR</i> gene (2000)

Conference Abstract| October 01 2000 Sequence variations in the TIGR gene Y. F. Leung; Y. F. Leung 1Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, 3/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong Search for other works by this author on: This Site PubMed Google Scholar J. K. H. Chua; J. K. H. Chua 1Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, 3/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong Search for other works by this author on: This Site PubMed Google Scholar L. Baum; L. Baum 1Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, 3/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong Search for other works by this author on: This Site PubMed Google Scholar D. S. P. Fan; D. S. P. Fan 1Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, 3/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong Search for other works by this author on: This Site PubMed Google Scholar D. S. C. Lam; D. S. C. Lam 1Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, 3/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong Search for other works by this author on: This Site PubMed Google Scholar C. P. Pang C. P. Pang 1Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, 3/F Hong Kong Eye Hospital, 147K Argyle Street, Kowloon, Hong Kong Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (2000) 28 (5): A301. https://doi.org/10.1042/bst028a301b Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation Y. F. Leung, J. K. H. Chua, L. Baum, D. S. P. Fan, D. S. C. Lam, C. P. Pang; Sequence variations in the TIGR gene. Biochem Soc Trans 1 October 2000; 28 (5): A301. doi: https://doi.org/10.1042/bst028a301b Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 2000 Biochemical Society2000 Article PDF first page preview Close Modal You do not currently have access to this content.
A Conversation Between Joanna Fowler and Johannes Czernin (2019)

![Figure][1]</img> Joanna S. Fowler, PhD Johannes Czernin, editor in chief of The Journal of Nuclear Medicine, earlier this year initiated a series of recorded discussions with leaders in nuclear medicine and molecular imaging. For this issue, he talked with Joanna Fowler, PhD, senior chemist
LDPC-Coded MIMO Optical Communication Over the Atmospheric Turbulence Channel (2008)

In this paper, coded multiple-input-multiple-output (MIMO) communication schemes for data transmission over the optical atmospheric turbulence channels are studied. Two strategies are proposed and compared. The first is based on repetition coding, and the second on space-time (ST) coding. Both approaches employ low-density parity-check (LDPC) codes. The LDPC codes are designed using the concept of pairwise balanced design (PBD), balanced incomplete block design (BIBBD), and block-circulant (array) codes. To improve the spectral efficiency, we employ a bit-interleaved (BI) LDPC-coded modulation based on the pulse amplitude modulation (PAM). A better bit error rate (BER) performance is achieved by the iteration of extrinsic information between a demapper and LDPC decoder. The simulations show that the LDPC-coded MIMO schemes can operate under a strong atmospheric turbulence and at the same time provide excellent coding gains compared with the transmission of uncoded data. To verify the efficiency of the proposed coding schemes, achievable information rates are computed when the turbulence is modeled by a gamma-gamma distribution.
Kerr microcombs based on soliton crystals for high-speed, scalable optical neural networks (2020)

Optical artificial neural networks (ONNs) have significant potential for ultra-high computing speed and energy efficiency. We report a new approach to ONNs based on integrated Kerr micro-combs that is programmable, highly scalable and capable of reaching ultra-high speeds, demonstrating the building block of the ONN — a single neuron perceptron — by mapping synapses onto 49 wavelengths to achieve a single-unit throughput of 11.9 Giga-OPS at 8 bits per OP, or 95.2 Gbps. We test the perceptron on handwritten-digit recognition and cancer-cell detection — achieving over 90% and 85% accuracy, respectively. By scaling the perceptron to a deep learning network using off-the-shelf telecom technology we can achieve high throughput operation for matrix multiplication for real-time massive data processing.
Fault detection method in subsea power distribution systems using statistical optimisation (2020)

Developing automation solutions that enable remote communications, monitoring and control for subsea applications are key steps in designing subsea power distribution systems. These systems require fast local control to protect the multiple electrical loads and the capability of transferring prompt real‐time trip signals. This study introduces a data‐driven distributed fault detection and identification algorithm to monitor multiple subsea loads. The proposed scheme is divided into three steps. First, a stochastic hidden‐Markov model (HMM) is developed to model the dynamic evolution of different potential conditions of multiple subsea loads. Simultaneously, the second step computes a model of the transition probability between the current operating condition and the potential response of an individual load. In the third step, using real‐time measurements, the HMM is updated to predict an unobserved degradation of the load's current condition. This is achieved through an integrated perturbation analysis and sequential quadratic programming method. An assessment of case studies on subsea AC power system is presented, which includes different subsea motor loads for compressors and pumps. Results show robustness against uncertainty in measurement noise and changes in equipment mean time between failures, providing enhanced reliability.
Proteomic Methods for Biomarker Discovery in a Rat Model of Alcohol Steatosis (2012)

Understanding changes in the expression of specific proteins and/or alterations in their posttranslational modifications is crucial to elucidating the molecular mechanisms underlying disease states such as alcoholic liver disease. Protein separation and analysis techniques such as two-dimensional electrophoresis and mass spectrometry can be used for identifying biomarker proteins that are altered during progression of alcoholic liver disease. In this chapter, we outline methods for resolving liver tissue proteins from a rodent model of alcoholic liver disease using two-dimensional electrophoresis and identifying differentially expressed proteins using mass spectrometry. In addition, since oxidative stress strongly correlates with alcoholic liver disease, we also describe methods for identifying oxidatively modified proteins from liver tissue. We specifically focus on identifying proteins that are carbonylated as protein carbonylation is a permanent modification and considered deleterious to cells. The combination of two-dimensional electrophoresis for protein resolution, mass spectrometry for protein identification, and affinity-based methods for enriching and identifying carbonylated proteins is a powerful methodology for protein biomarker identification.
Insulator-superfluid transition of spin-1 bosons in an optical lattice in magnetic field (2003)

We study the insulator-superfluid transition of spin-1 bosons in an optical lattice in a uniform magnetic field. Based on a mean-field approximation we obtained a zero-temperature phase diagram. We found that depending on the particle number the transition for bosons with antiferromagnetic interaction may occur into different polar superfluid phases with spins aligned along or opposite to the field direction. This is qualitatively different from the field-free transition for which the mean-field theory predicts a unique polar superfluid state for any particle number.
Non invasive <i>in vivo</i> monitoring of dimethyl fumarate treatment in EAE by assessing the glucose metabolism in secondary lymphoid organs (2020)

[<sup>18</sup> F]FDG-PET/CT is a high sensitive functional diagnostic imaging modality to monitor tumor but also immune cell activation by determination of the glucose metabolism. Our results show that the anti-inflammatory effects of immunotherapeutics like DMF can be assessed non invasively in vivo during Th1/Th17 cell-mediated encephalomyelitis (EAE) by [<sup>18</sup> F]FDG-PET/CT imaging of the draining lymph nodes.
Stochastically Optimized Monocular Vision-Based Guidance Design (2007)

This paper designs a relative navigation and guidance system for unmanned aerial vehicles for monocular vision-based control applications. Since 2-D vision-based measurement is nonlinear with respect to the 3-D relative state, an extended Kalman fllter (EKF) is applied in the navigation system design. It is well-known that the vision-based estimation performance highly depends on the relative motion of the vehicle to the target. Therefore, a main objective of this paper is to derive an optimal guidance law to achieve given missions under the condition that the EKF-based relative navigation outputs are fed back to the guidance system. This paper suggests a stochastic optimal guidance design that minimizes the expected value of a cost function of the guidance error and control efiort subject to the EKF prediction and update procedures. A one-step-ahead suboptimal optimization technique is implemented to avoid iterative computations. The approach is applied to vision-based target tracking and obstacle avoidance, and simulation results are illustrated.
Slot antenna on perfectly conducting spheroid coated with homogeneous materials (1996)

Slot antennas on dielectric-coated perfectly conducting objects have extensively been studied by many investigators. For these problems, exact analytic solutions are available only for a limited number of geometries. These geometries include circular and elliptic cylinders, as well as, spheres and spheroids. Since these solutions maintain mathematical rigor, they provide not only exact solutions for their respective geometries, but also the evaluation of approximate and numerical solutions. The slot antennas on a dielectric-coated sphere and circular cylinder have been investigated by Shafai[1], Lin[2] and other authors. Slot antennas on a coated spheroid, on the other hand, have been discused by Wait [3] and Weeks[4], but their discussions are only for the rotationally symmetric slots. A more general case, the nonsymmetric slots, have not been studied extensively, and, it is the subject of this paper.
The 2019 American College of Rheumatology/European League Against Rheumatism Classification Criteria for IgG4‐Related Disease (2019)

ACR/EULAR classification criteria for IgG4-RD have been developed and validated in a large cohort of patients. These criteria demonstrate excellent test performance and should contribute substantially to future clinical, epidemiologic, and basic science investigations.
Stem Cells for Myocardial Regeneration (2011)

The field of cardiovascular regenerative medicine has made significant strides over the past decade. Clinical trials have demonstrated benefit in acute myocardial infarction (AMI) and chronic heart failure (CHF). As the field has matured, it has defined novel biology and invented an array of therapeutic strategies that are currently under development. In this brief review, we attempt to conceptualize the knowledge to date as well as examine how this knowledge has been translated to various therapeutic strategies.
Genetic Analysis of<i>chs1</i><sup>+</sup>and<i>chs2</i><sup>+</sup>Encoding Chitin Synthases from<i>Schizosaccharomyces pombe</i> (2004)

To explore the function of chitin in Schizosaccharomyces pombe, we have cloned chs1+ and chs2+, encoding putative chitin synthases, based on sequences in the Sanger Centre database. The synthetic lethal phenotype of the S. cerevisiae chs1 chs2 chs3 mutant was complemented by expression of S. pombe chs1+ or chs1+, indicating that both chs1+ and chs2+ in fact encode chitin synthase. The homothallic Deltachs1 strain formed abnormal asci that contained 1, 2, or 3 spores, while the Deltachs2 strain had no noticeable phenotype. The chs1 chs2 double disruptant looked similar phenotypically to the Deltachs1 strain. The Chs2-GFP fusion protein predominantly localized at the septum after the septum was formed during vegetative growth. The level of chs2+ mRNA increased just before the septum was formed. Levels of Chs2-13Myc synthesis also changed during the cell cycle. Thus, chs1+ is required for proper spore formation, and chs2+ is perhaps involved in septum formation.
Pyroelectric single-element detectors for special applications (2004)

This paper describes the set-up and the essential features of pyroelectric single-element detectors on the basis of lithium tantalate (LiTaO<sub>3</sub>). They have been developed for special applications in pyrometry, analytics and security techniques and are optimized for a maximum possible signal-to-noise ratio. Important detector characteristics (responsivity, specific detectivity) and of disturbances (acceleration sensitivity) as a function of the chopper frequency and the detector layout can be theoretically calculated on the basis of various mathematical and physical models. The latter take particular account of the thermal, electric, mechanical and optical conditions in the sensor. It is shown that the specific detectivity of the components can be essentially increased by using selected components (low-noise SFET, inert gas) for the detector and by applying various technologies for the manufacturing of the responsive element for certain chopper frequencies. For example, a specific detectivity of <i>D</i>* (500 K; 10 Hz; 1 Hz; &tau;<sub><i>F</i></sub> = 1) &ge; 1.5 x 10<sup>9</sup> cmHz<sup>1/2</sup>W<sup>-1</sup> has been obtained for LiTaO<sub>3</sub> detectors with a responsive area of [3x3] mm<sup>2</sup>. Moreover, the acceleration sensitivity could be reduced by choosing special chip and detector layouts. As a result, this paper confirms a good correspondence between the measured and calculated values of the detector characteristics. This paper also presents innovative detector designs (integrated optics, three-dimensionally structured LiTaO<sub>3</sub> chips) and their basic properties.
Supplementary Table S2 from Large-scale Identification of Clonal Hematopoiesis and Mutations Recurrent in Blood Cancers (2023)

&lt;p&gt;Comparison of identified hotspots&lt;/p&gt;
High-performance integrated-optical chip for a broad range of fiber-optic gyro applications (1990)

A high-performance integrated-optical device for a broad range of fiber-optic gyro applications is reported. The circuit contains four directional couplers and six phase modulators that form the fiber-loop coupler, the bias and serrodyne phase modulators, and an on-chip interferometric serrodyne phase detector. The chip was fabricated by the annealed-proton-exchange method in X-cut LiNbO(3), which yielded a highly polarizing guided circuit with a polarization extinction ratio of at least 60 dB. Other performance parameters include low half-wave voltages (3.5-5.5 V) at 1.3 microm and splitting and tapping directional coupler parameters well within the design needs required by application.
The Brain-Gut Axis Contributes to Neuroprogression in Stress-Related Disorders (2017)

There is a growing emphasis on the relationship between the complexity and diversity of the microorganisms that inhabit our gut (human gastrointestinal microbiota) and brain health. The microbiota-gut-brain axis is a dynamic matrix of tissues and organs including the brain, glands, gut, immune cells, and gastrointestinal microbiota that communicate in a complex multidirectional manner to maintain homeostasis. Changes in this environment may contribute to the neuroprogression of stress-related disorders by altering physiological processes including hypothalamic-pituitary-adrenal axis activation, neurotransmitter systems, immune function, and inflammatory responses. While appropriate, coordinated physiological responses, such as immune or stress responses, are necessary for survival, the contribution of repeated or chronic exposure to stress may predispose individuals to a more vulnerable state leaving them more susceptible to stress-related disorders. In this chapter, the involvement of the gastrointestinal microbiota in stress- and immune-mediated modulation of neuroendocrine, immune, and neurotransmitter systems and the consequential behavior is considered. We also focus on the mechanisms by which commensal gut microbiota can regulate neuroinflammation and further aim to exploit our understanding of their role in the effects of the microbiota-gut-brain axis on the neuroprogression of stress-related disorders as a consequence of neuroinflammatory processes.
Essential role of <i>BETA2/NeuroD1</i> in development of the vestibular and auditory systems (2000)

BETA2/NeuroD1 is a bHLH transcription factor that is expressed during development in the mammalian pancreas and in many locations in the central and peripheral nervous systems. During inner ear ontogenesis, it is present in both sensory ganglion neurons and sensory epithelia. Although studies have shown that BETA2/NeuroD1 is important in the development of the hippocampal dentate gyrus and the cerebellum, its functions in the peripheral nervous system and in particular in the inner ear are unclear. Mice carrying a BETA2/NeuroD1 null mutation exhibit behavioral abnormalities suggestive of an inner ear defect, including lack of responsiveness to sound, hyperactivity, head tilting, and circling. Here we show that these defects can be explained by a severe reduction of sensory neurons in the cochlear-vestibular ganglion (CVG). A developmental study of CVG formation in the null demonstrates that BETA2/NeuroD1 does not play a primary role in the proliferation of neuroblast precursors or in their decision to become neuroblasts. Instead, the reduction in CVG neuron number is caused by a combination both of delayed or defective delamination of CVG neuroblast precursors from the otic vesicle epithelium and of enhanced apoptosis both in the otic epithelium and among those neurons that do delaminate to form the CVG. There are also defects in differentiation and patterning of the cochlear duct and sensory epithelium and loss of the dorsal cochlear nucleus. BETA2/NeuroD1 is, thus, the first gene to be shown to regulate neuronal and sensory cell development in both the cochlear and vestibular systems.
Efficient Similarity Retrieval for Temporal Shape Sequences: A Case Study using Cardiac MR Images (2005)

The spherical harmonics (SPHARM) approach has been used for the representation of shapes in many types of biomedical image data. We propose a SPHARM-based similarity comparison for shape sequences that allows fast similarity searches for dynamic objects and demonstrate it using 3D images of a beating heart. By using spherical harmonics to extract a small number of features that represent cardiac shape in each sequential state, we enable indexing and pruning of database entries with a multidimensional index tree (e.g. R*-tree) for fast retrieval. Our approach relies on obtaining selected landmarks to allow normalization within and between sequences. This framework is extensible to other application domains.
Impact of Propellant Species on Hall Effect Thruster Electrical Facility Effects (2017)

The impact of propellant species on the role of the conductive vacuum chamber wall in the discharge circuit of the 200 W T-40 Hall effect thruster is experimentally investigated using xenon and krypton propellants at operating pressures of . Aluminum plates are placed adjacent to, but electrically isolated from, the facility walls downstream along thruster centerline and radially outward, centered on the exit plane. Data are acquired for four plate electrical configurations: 1) biased relative to ground with measurements of collected current, 2) grounded with measurements of currents to ground, 3) floating with measurements of floating voltages, and 4) connected with measurements of the current conducted between the plates. The 42% decrease in ion beam current associated with krypton operation resulted in a 58 and 19% decrease in the collected current to ground and floating voltage, respectively, of the axial plate; the 10% increase in divergence half-angle with krypton propellant yielded a change in sign for the collected current to ground and floating voltage of the radial plate. These findings suggest that changes to the ion current density profile cause concomitant changes to electrical coupling between the Hall effect thruster and test facility.
Stop-and-Wait Hybrid-ARQ performance at IP level under imperfect feedback (2012)

International audience
A MINIMALLY-INVASIVE APPROACH TO THE CHALLENGE OF ORAL NEOPLASIA (2013)

Author(s): Mittal, Richa; Balu, Mihaela; Liu, Gangjun; Chen, Zhongping; Tromberg, Bruce; Wilder-Smith, Petra; Potma, Eric
The investigation for introduction of SAC etching technique to mass productive DRAM process (2002)

A self aligned contact hole (SAC) etching technique has been investigated for a mass production DRAM process. A Dipole Ring Magnetron RIE (DRMRIE) system with CO additional C4F8 gas chemistry is applied to SAC etching because of its maturity with consideration of COO and COC. Hardware improvement and process optimization can widen the process window 9 times as large. Stopper Si/sub 3/N/sub 4/ removal process and device characteristics are evaluated to decide minimum limitation of SAC shoulder residue. In-line observation with SEM measurement is employed for administration of the SAC process. Stable process repeatability is realized and a successful SAC process for mass production is completed in this examination.
Does Rose Bengal Triplet Generate Superoxide Anion? (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTDoes Rose Bengal Triplet Generate Superoxide Anion?Christopher R. Lambert and Irene E. KochevarView Author Information Wellman Laboratories of Photomedicine Department of Dermatology, Harvard Medical School Massachusetts General Hospital Boston, Massachusetts 02114 Cite this: J. Am. Chem. Soc. 1996, 118, 13, 3297–3298Publication Date (Web):April 3, 1996Publication History Received10 January 1996Published online3 April 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja9600800https://doi.org/10.1021/ja9600800rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views1115Altmetric-Citations76LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Absorption,Charge transfer,Kinetic parameters,Lasers,Quenching Get e-Alerts