gebhart/patrepeval huggingface dataset:
Suppression of innate inflammation and immunity by interleukin‐37 (2016)

IL-37 is unique in the IL-1 family in that unlike other members of the family, IL-37 broadly suppresses innate immunity. IL-37 can be elevated in humans with inflammatory and autoimmune diseases where it likely functions to limit inflammation. Transgenic mice expressing human IL-37 (IL37-tg) exhibit less severe inflammation in models of endotoxin shock, colitis, myocardial infarction, lung, and spinal cord injury. IL37-tg mice have reduced antigen-specific responses and dendritic cells (DCs) from these mice exhibit characteristics of tolerogenic DCs. Compared to aging wild-type (WT) mice, aging IL37-tg mice are protected against B-cell leukemogenesis and heart failure. Treatment of WT mice with recombinant human IL-37 has been shown to be protective in several models of inflammation and injury. IL-37 binds to the IL-18 receptor but then recruits the orphan IL-1R8 (formerly TIR8 or SIGIRR) in order to function as an inhibitor. Here, we review the discovery of IL-37, its production, release, and mechanisms by which IL-37 reduces inflammation and suppresses immune responses. The data reviewed here suggest a therapeutic potential for IL-37.
Towards a Data-Driven Digital Twin for the Aging Prediction of Aircraft Composite Components Airworthiness Accounting for Flight and Environmental Conditions (2021)

Machine Learning (ML) and Digital Twins (DT) are at the heart of today’s different industries, ranging from advanced manufacturing to biomedical systems to resilient ecosystems, civil infrastructures, smart cities, and healthcare. They have become indispensable for solving complex problems in science, engineering, and technology development. The purpose of the MMLDT-CSET 2021 conference is to facilitate the transition of ML and DT from fundamental research to mainstream fields and technologies through advanced data science, mechanistic methods, and computational technologies. This 3-day conference features technical tracks of emerging ML-DT fields and applications, special public lectures, short courses, and demonstrations. The conference will be held in a hybrid format, featuring both on-site and virtual sessions.
Molecular Design of Novel Ligands for 5-HT<sub>1A</sub>Receptors (1991)

Serotonin (5-HT) is a potent bioactive substance known to function through a number of different receptor types and subtypes. In our attempt to develop new agents that would interact selectively at certain 5-HT receptors, especially the 5-HT1A subtype, 8-hydroxy-2-di-n-propylamino tetralin (8-OH-DPAT) served as a template for the design of novel agents sharing aspects of the pharmacophore of 8-OH-DPAT and 5-HT. 5-HT contains no center of asymmetry, and 8-OH-DPAT shows only very modest stereospecificity for 5-HT1A receptors. To develop agents having enhanced potency and selectivity for the 5-HT1A site, several ring systems offering enhanced conformational rigidity which approximate the oxygen to nitrogen interatomic distances of 8-OH-DPAT and (to a lesser extent) 5-HT were synthesized. Exemplary ring systems include the 8-alkoxy-hexahydroindeno[1,2-c]pyrrole, 5-alkoxy-hexahydro-1H-indeno-[2,1-c]pyridine, and 9-alkoxy-hexahydro-1H-benz[e]isoindole systems. These conformationally restricted molecules demonstrated moderate stereospecificity in their interaction with the 5-HT1A binding site, which was enhanced in compounds with larger nitrogen substituents. Appropriate choice of such derivatives led to highly potent compounds selective for 5-HT1A sites compared with their activity at other 5-HT and/or adrenergic receptors. The pharmacological profile of compounds which appear to act as agonists at 5-HT1A receptors in the central nervous system to lower blood pressure in animal models of hypertension is presented.
Polymerically modified layered silicates: an effective route to nanocomposites. (2008)

Polymer/clay nanocomposites have been under an extensive investigation for about 15 years. Traditional methods to modify the clay are usually limited to small organic cations, preferably containing long alkyl chain(s), which are exchanged with the inorganic cations in the clay gallery. This article provides a comprehensive review on the strategies for clay modification using polymeric surfactants or polycations: from the synthesis of such surfactants, through the preparation of the polymerically modified clays, and to the fabrication of the respective polymer nanocomposites and their properties.
A wideband antenna for P-band airborne SAR applications (2008)

A new wideband antenna for airborne SAR applications has been presented. It is based on a geometry that gives a stable phase center. It allows to have a rejection of the ground response ambiguity of more than 34 dB. Its bandwidth (defined for a S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> les -8 dB, with a gain ges 5 dB) is 245-390 MHz (45%). Further works will include the improvement of the S11, along with a size reduction of the LPDA to improve the front to back ratio. Finally, a prototype has to be built.
Submaximal and Maximal Cardiorespiratory Responses of Leg Wheeling and Arm Wheeling a New Wheelchair Prototype (2004)

The present study examined the cardiorespiratory responses to propelling a new wheelchair prototype using a unique type of leg wheeling (LW) that allowed the subjects to propel the wheelchair using bilateral knee extension/flexion. Comparisons were made to arm wheeling (AW) and to treadmill running (TR) using a standard maximal oxygen consumption test to exhaustion. Nine female able-bodied subjects performed three incremental submaximal exercise bouts followed by exercise to exhaustion using AW and LW. The results showed that LW was more efficient than AW, as evidenced by lower cardiorespiratory effort at the same submaximal intensity during LW, and a lower physiological cost index (PCI—change in heart rate divided by velocity of wheeling) during maximal workloads. LW also elicited significantly higher peak cardiorespiratory values than AW but not TR. The cardiorespiratory variables measured during LW were also highly reliable. In conclusion, this unique form of LW was more efficient than AW during submaximal and maximal exercise.
Maxillary and mandibular reconstruction using vascularized fibular bone (2014)

2002年4月から2013年3月の間，悪性腫瘍の上下顎骨切除および合併症症例は33例であった。これらに対する再建法の内訳については，腓骨による顎骨再建症例が19例，再建用チタンプレートによる下顎骨再建症例が8例，硬性再建なしが6例であった。腓骨再建症例19例中7例が義歯を使用していた。その内1例は食事の際に義歯は外し，残りの6例は義歯を使用していた。しかし健側と患側の両方で咬んでいる症例は1例のみであった。インプラント義歯は上顎歯槽部再建例1例と下顎骨再建例2例で施行された。患者インタビューから，インプラント義歯は咀嚼機能の向上に寄与するものと思われた。歯科用骨内インプラントとそれに装着するインプラント義歯の保険適用によって，今後インプラントは広く普及すると考えられる。その有効性について，咀嚼機能のみならず，口腔機能全体の向上や審美面および心理的影響について，多面的な観点からエビデンスを示していく必要がある。
Modulation of the Glucagon-Dependent Induction of Phosphoenolpyruvate Carboxykinase and Tyrosine Aminotransferase by Arterial and Venous Oxygen Concentrations in Hepatocyte Cultures (1981)

Periportal and perivenous hepatocytes are heterogeneous as to their outfit with enzymes and subcellular structures. The influence of different physiological oxygen concentrations on gene expression was studied in primary cultures of adult rat hepatocytes. 1 In 24-cultures the activities of phosphoenolpyruvate carboxykinase andtyrosine aminotransferase, which are predominantly located in periportal cells, were increased by glucagons(0.1 μmol/1)within 4 h to higher levels under 13%(v/v)oxygen in the gas atmosphere (mimicking arterial oxygen concentrations)than under 6%(v/v)oxygen (mimicking venous oxygen concentrations). The increase was due to enzyme induction as indicated by its prevention with cycloheximide or actinomycin D and by direct immunochemical titration. 2 Half-maximal induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase was obtained under high and low oxygen tensions with glucagons concentrations around 0.5 nmol/1. 3 The induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase by glucagons showed a sigmoidal rather than a linear dependence on oxygen tension; the range of highest sensitivity was found to be between 8% and 11% oxygen(v/v). 4 The oxygen dependence of the induction of phosphoenolpyruvate carboxykinase and tyrosine aminotransferase was probably specific and did not reflect a general impairment of energy metabolism. In the hapatocytes cultured under 13% and 6% oxygen (v/v) a)the adenine nucleotide levels were essentially the same the energy charge being 0.89;(b)the oxygen consumption was similar, 2.42±0.10 and 2.27±0.26μmol min −1wet weight −1; and (c)incorporation of [14] leucine into cellular protein as a measure of general protein synthesis amounted to 6.9 ±0.38 and 6.0 ± 0.4. nmol min −1mg DNA−1. The present results demonstrate that different physiological oxygen tensions can modulate the induction of liver enzymes and can thus contribute to the heterogeneity of hapatocytes.
Subatmospheric electrospray interface for coupling of microcolumn separations with mass spectrometry (2000)

A modular subatmospheric electrospray interface with fiber optic UV detection close to the electrospray tip was developed for coupling of microcolumn separation techniques with mass spectrometry. The interface was based on a liquid junction with a removable microelectrospray tip. The electrospray tip was enclosed in a subatmospheric chamber attached in front of the sampling orifice of the mass spectrometer. The inlet of the liquid junction was maintained at atmospheric pressure, and thus no pressure drop developed across the separation column. The flow rate of the electrosprayed liquid from the liquid junction reservoir was adjusted by the pressure in the electrospray chamber. In this approach, a continuous and stable electrospray could be achieved without the use of an external pump. Since the electrospray did not depend on fluid delivery from the separation column, coated capillaries without electroosmotic flow as well as capillaries with electroosmotic flow could be used for capillary electrophoresis. In addition, the interface was found to be effective with capillary liquid chromatography. The use of a fiber optic UV detector placed close to the exit of the separation column provided additional detection information and a simple means of troubleshooting. The interface did not significantly influence the quality of the separation, even with columns generating several hundred thousand theoretical plates. Peptide samples in the submicromolar concentration range were detected, corresponding to a limit of detection in the attomole range.
Effects of p21<sup>Waf1/Cip1/Sdi1</sup>on cellular gene expression: Implications for carcinogenesis, senescence, and age-related diseases (2000)

Induction of cyclin-dependent kinase inhibitor p21(Waf1/Cip1/Sdi1) triggers cell growth arrest associated with senescence and damage response. Overexpression of p21 from an inducible promoter in a human cell line induces growth arrest and phenotypic features of senescence. cDNA array hybridization showed that p21 expression selectively inhibits a set of genes involved in mitosis, DNA replication, segregation, and repair. The kinetics of inhibition of these genes on p21 induction parallels the onset of growth arrest, and their reexpression on release from p21 precedes the reentry of cells into cell cycle, indicating that inhibition of cell-cycle progression genes is a mechanism of p21-induced growth arrest. p21 also up-regulates multiple genes that have been associated with senescence or implicated in age-related diseases, including atherosclerosis, Alzheimer's disease, amyloidosis, and arthritis. Most of the tested p21-induced genes were not activated in cells that had been growth arrested by serum starvation, but some genes were induced in both forms of growth arrest. Several p21-induced genes encode secreted proteins with paracrine effects on cell growth and apoptosis. In agreement with the overexpression of such proteins, conditioned media from p21-induced cells were found to have antiapoptotic and mitogenic activity. These results suggest that the effects of p21 induction on gene expression in senescent cells may contribute to the pathogenesis of cancer and age-related diseases.
Seasonal variation in objectively measured physical activity, sedentary time, cardio-respiratory fitness and sleep duration among 8–11 year-old Danish children: a repeated-measures study (2013)

Overall, sedentary time was higher and physical activity lower during winter and during weekends. The most accurate and unbiased estimates of physical activity came from autumn; however, the considerable intra-individual variation suggests that a single measurement may not adequately characterise children's habitual sleep and activity.
Incorporating male sterility increases hybrid maize yield in low input African farming systems (2022)

Maize is a staple crop in sub-Saharan Africa, but yields remain sub-optimal. Improved breeding and seed systems are vital to increase productivity. We describe a hybrid seed production technology that will benefit seed companies and farmers. This technology improves efficiency and integrity of seed production by removing the need for detasseling. The resulting hybrids segregate 1:1 for pollen production, conserving resources for grain production and conferring a 200 kg ha<sup>-1</sup> benefit across a range of yield levels. This represents a 10% increase for farmers operating at national average yield levels in sub-Saharan Africa. The yield benefit provided by fifty-percent non-pollen producing hybrids is the first example of a single gene technology in maize conferring a yield increase of this magnitude under low-input smallholder farmer conditions and across an array of hybrid backgrounds. Benefits to seed companies will provide incentives to improve smallholder farmer access to higher quality seed. Demonstrated farmer preference for these hybrids will help drive their adoption.
A neurodynamic optimization approach to robust TDOA-based IoT localization using unreliable sensor data (2020)

This paper considers the problem of time-difference-of-arrival (TDOA) source localization using possibly unreliable data collected by the Internet of Things (IoT) sensors in the error-prone environments. The Welsch loss function is integrated into a hardware realizable projection-type neural network (PNN) model, in order to enhance the robustness of location estimator to the erroneous measurements. For statistical efficiency, the formulation here is derived upon the underlying time-of-arrival composition via joint estimation of the source position and onset time, instead of the TDOA counterpart generated in the postprocessing of sensor-collected timestamps. The local stability conditions and implementation complexity of the proposed PNN model are also analyzed in detail. Simulation investigations demonstrate that our neurodynamic TDOA localization solution is capable of outperforming several existing schemes in terms of localization accuracy and computational efficiency.
Spatial near‐infrared imaging of hydroxyl band coverage on ceria‐based catalysts (2005)

Abstract High‐throughput near‐infrared imaging was used to distinguish catalyst activity for low‐temperature methane steam‐reforming. Geminal hydroxyls of reduced ceria were depicted during methane reforming at 673 K. The changes in absorbance maps under various water partial pressures showed evidence of formate intermediate formations without redox exchanges. Higher resolution was observed in absorbance change images than that of thermal images obtained from catalyst surface self‐emissions. The experimental results illustrated higher activity of pure rhodium catalyst than that of bimetallic ones, likely because of the high dispersion of rhodium on the catalyst support. Moreover, the reaction was accelerated when high surface area silica was added because more reduced sites were exposed. Our filter bandwidths limited our interest in band‐shift distribution of geminal hydroxyl band during the reduction process. © 2005 American Institute of Chemical Engineers AIChE J, 2006
Towards Characterization of the Human Urinary Peptidome (2005)

Biomarker discovery in human urine has become an evolving and potentially valuable topic in relation to renal function and diseases of the urinary tract. In order to deliver on the promises and to facilitate the development of validated biomarkers or biomarker panels, protein and peptide profiling techniques need high sample throughput, speed of analysis, and reproducibility of results. Here, we outline the performance characteristics of the liquid chromatography/MALDI-TOF-MS based differential peptide display (DPD(1)) approach for separating, detecting, abundance profiling and identification of native peptides derived from human urine. The typical complexity of peptides in human urine (resolution of the technique with respect to detectable number of peptides), the reproducibility (coefficient of variation for abundance profiles of all peptides detected in biological samples) and dynamic range of the technique as well as the lower limit of detection were characterized. A substantial number of peptides present in normal human urine were identified and compared to findings in four published proteome studies. In an explorative approach, pathological urines from patients suffering from post-renal-filtration diseases were qualitatively compared to normal urine. In conclusion, the peptidomics technology as shown here has a great potential for high throughput and high resolution urine peptide profiling analyses. It is a promising tool to study not only renal physiology and pathophysiology and to determine new biomarkers of renal diseases; it also has the potential to study remotely localized or systemic aberrations within human biology.
Etude par spectrométrie mécanique de la mobilité moléculaire dans les alliages de polymères non cristallins de comptabilité différente (1987)

Etude de la deformation non elastique de melanges de polymeres amorphes par spectrometrie mecanique. Etude theorique de la relaxation structurale des polymeres amorphes. Etude de la morphologie des differentes phases des melanges
ChemInform Abstract: Enantiospecific Total Synthesis of (‐)‐Anhydromacrosalhine‐methine and Partial Synthesis of the Antiamoebic Bisindole Alkaloid (‐)‐Macrocarpamine. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Gate-oxide reliability and failure-rate reduction of industrial SiC MOSFETs (2020)

We discuss various gate-oxide reliability aspects of silicon carbide (SiC) MOSFETs and highlight similarities and differences of SiC and silicon (Si) technology. Basic concepts of electrical gate-oxide defect screening are introduced and failure probability and the failure-rate after screening is studied based on Weibull statistics. To be able to quantify very low extrinsic failure probabilities (e.g. after electrical screening), we present a new kind of test procedure which we call the "marathon stress test". The results of this test demonstrate that excellent gate-oxide reliability of commercially available SiC trench MOSFETs can be achieved after applying a sufficiently precise electrical screening.
Non-monotonic Response to Monotonic Stimulus: Regulation of Glyoxylate Shunt Gene-Expression Dynamics in Mycobacterium tuberculosis (2016)

Understanding how dynamical responses of biological networks are constrained by underlying network topology is one of the fundamental goals of systems biology. Here we employ monotone systems theory to formulate a theorem stating necessary conditions for non-monotonic time-response of a biochemical network to a monotonic stimulus. We apply this theorem to analyze the non-monotonic dynamics of the σB-regulated glyoxylate shunt gene expression in Mycobacterium tuberculosis cells exposed to hypoxia. We first demonstrate that the known network structure is inconsistent with observed dynamics. To resolve this inconsistency we employ the formulated theorem, modeling simulations and optimization along with follow-up dynamic experimental measurements. We show a requirement for post-translational modulation of σB activity in order to reconcile the network dynamics with its topology. The results of this analysis make testable experimental predictions and demonstrate wider applicability of the developed methodology to a wide class of biological systems.
Information-theoretic characterizations of Markov random fields and subfields (2017)

Let X <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> , i ϵ V form a Markov random field (MRF) represented by an undirected graph G = (V, E), and V' be a subset of V. We determine the smallest graph that can always represent the subfield X <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> , i ϵ V' as an MRF. Based on this result, we obtain a necessary and sufficient condition for a subfield of a Markov tree to be also a Markov tree. When G is a path so that X <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">i</sub> , i ϵ V form a Markov chain, it is known that the I - Measure is always nonnegative [3]. We prove that Markov chain is essentially the only MRF that possesses this property. Our work is built on the set-theoretic characterization of an MRF in [4]. Unlike most works in the literature, we do not make the standard assumption that the underlying probability distribution is factorizable with respect to the graph representing the MRF.
A quantum neural net: with applications to materials science (1999)

A neural network architecture suitable for learning and generalization is discussed and developed. The architecture is inspired and modeled after quantum electronic devices and circuits where coherent electronic wavefunctions traveling through different parts of the circuit are combined together and result in interferences at detection nodes. These wavefunctions, represented by complex numbers, are implemented as complex weights in our neural net architecture to efficiently and accurately facilitate certain computations. Although similar to the radial basis function (RBF) net, our computational model called quantum net (QN) has demonstrated a considerable gain in performance and efficiency in number of applications compared to RBF net. Its better performance in classification tasks is explained by the cross-product terms in internal representation of its basis functions introduced parsimoniously. These cross-products are the results of interferences naturally occurring in coherent electronic systems. Although we primarily discuss the software implementation of QN on Von Neuman computers, its hardware implementation is also briefly discussed. A number of examples, solved using QN and other networks, are used to illustrate the desirable characteristics of QN.
ESTIMATION OF ELECTRICITY AND COOLING/HEATING DEMAND ON KEIO UNIVERSITY SHONAN FUJISAWA CAMPUS (2006)

We investigated the electricity and gas consumption on Keio University Shonan Fujisawa Campus from November 1, 2004 to October 31, 2005. As a result, the relation between the energy consumption and ambient temperature was correlated by a linear function. On the basis of the correlation, we estimated the electricity and gas consumption of each air-conditioning system hourly. Furthermore, cooling and heating demand were estimated by applying coefficient of performance of air-conditioning equipment to the electricity and gas consumption. The characteristics of energy demand in universities would be determined from the objective of the space such as office, classroom, media center, research room, etc. Therefore, the information on energy demand for each space is necessary to design the capacity of air-conditioning and power facilities appropriately. We tried to estimate cooling and heating demand hourly for each space described above, and figured out the characteristics of the demand.