gebhart/patrepeval huggingface dataset:
Comparison of the immune response against polio peptides covalently-surface-linked to and internally-entrapped in liposomes. (1991)

The adjuvanticity of liposomes on two different modes of presentation of polio virus subunit peptides was demonstrated by incorporating the poorly immunogenic synthetic polio peptides, W1 and W2, into the internal space of and covalently-linked to the surface of dehydration-rehydration vesicles (DRV). It was found that for both peptides, liposome association in either mode boosted the primary and secondary IgG1 responses against 5 micrograms peptide as compared to controls in which free peptide was administered. Surface-linkage of peptides (both W1 and W2) exhibited an initially more rapid rise in antibody levels, as compared to internal entrapment of the peptides, but elicited no observable secondary response. However, although encapsulated W1 showed a milder primary response when compared to the surface-linked formulation, it later elicited a strong secondary response. These results suggested that it may be advantageous to administer liposomal virus subunit vaccines in both surface-linked and internally entrapped formulations to achieve adequate initial antibody levels followed by an anamnestic response.
Three-dimensional blood flow analysis in a wide-necked internal carotid artery—ophthalmic artery aneurysm (2003)

The side-wall aneurysm in this study did not demonstrate a simple flow pattern as was previously seen in ideally shaped experimental aneurysms in vitro and in vivo. The flow patterns of inflow and outflow zones were very difficult to predict based on the limited flow information provided on standard digital subtraction angiography, even in an aneurysm with a relatively simple dome shape.
Analysis of the role of CggR in Lactobacillus plantarum NC8 and WCFS1 by transcriptome analysis (2010)

The level of the Central glycolytic gene regulator (CggR) was engineered in Lactobacillus plantarum NC8 and WCFS1 by over-expression and in-frame mutation of the cggR gene in order to evaluate its regulatory role on the glycolytic gap operon and the glyco.
Asymmetric control of oxidation of aromatic substrates using a donor–acceptor interaction (1986)

M. Lemaire, A. Guy, D. Imbert and J. Guetté, J. Chem. Soc., Chem. Commun., 1986, 741 DOI: 10.1039/C39860000741
P060 The pharmacologic inhibition of store-operated calcium entry pathway in inflammatory bowel disease (2020)

Abstract Background Store-operated calcium entry (SOCE) represents the major calcium influx pathway in T cells which not only controls the activation and function of lymphocytes, but which also has been implicated in the metabolic homeostasis and survival of murine CD4+ and CD8+ T cells. Conditional knockout mice, in which SOCE signalling components are deleted in T cells, revealed that SOCE is required for the induction of intestinal inflammation in mouse models of colitis. However, the effects of SOCE inhibition have not been studied in inflammatory bowel disease (IBD) and it remains elusive, which immune cell subset is affected by the pharmaceutical blockade of SOCE. We therefore aim to investigate the effects of SOCE inhibitor BTP-2 on functions and metabolic homeostasis of human lymphocytes isolated from IBD patients. Methods PBMC and/or lamina propria lymphocytes were isolated from colitis patients undergoing colon resection and mass cytometry served in order to evaluate the cytokine production and activation of B, T, NK as well as myeloid cells. Additionally, Ca2+ influx measurement and Seahorse analyses were performed in order to assess the metabolic status of immune cell subsets after SOCE inhibition. Results Data on B, T, NK, myeloid cells and neutrophils isolated from peripheral blood or colon lamina propria revealed that each immune cell subset harbours a distinctive SOCE-dependent Ca2+ influx rate, suggesting that SOCE might differentially regulate the activation and function of each cell subtype. In particular, CD4+ and CD8+ T cells, B and NK cells as well as monocytes were highly susceptible to extracellular Ca2+ influx, followed by granulocytes. Furthermore, inhibition of SOCE in lymphocytes resulted in impaired metabolic fitness, reduced glycolytic capacity and impaired fatty acid oxidation. Finally, BTP-2 was able to decrease the production of key pro-inflammatory cytokines involved in IBD, including TNFα and IL-17 in lamina propria resident T cells. Conclusion Our data revealed for the first time that the cytokine production and the activation of several immune cell subtypes can be modulated by SOCE blockade in human intestinal inflammation, identifying SOCE as a novel therapeutic target in colitis. Moreover, we hope that a wide phenotypical characterisation of immune cells via mass cytometry will provide a better insight into positive as well as negative effects of SOCE inhibitors that might interfere with the clinical applicability of SOCE inhibitors for treating IBD.
Valence-to-core X-ray emission spectroscopy of vanadium oxide and lithiated vanadyl phosphate materials (2020)

Coupling lab-based XES measurements with computations amenable to solid-state systems revealed the valence band behavior of several vanadium-based electronic materials.
Combining current imaging, EBIC/EBAC, and electrical probing for fast and reliable in situ electrical fault isolation (2016)

Using a compact nanoprobing setup comprising eight probe tips attached to piezo-driven micromanipulators, various techniques for fault isolation are performed on 28 nm samples inside an SEM. The recently implemented Current Imaging technique is used to quickly image large arrays of contacts providing a means of locating faults.
Quantitative determination of bound water in cardboard by measurement of dielectric permittivity (2017)

In this study we investigated the complex dielectric permittivity of cardboard with different water contents using a coaxial transmission/reflection technique from 10 MHz to 1.5 GHz. A relaxation p ...
Time- and oxygen-dependent expression and regulation of NDRG1 in human brain cancer cells (2017)

N-myc downstream-regulated gene 1 (NDRG1) is a tumor suppressor with the potential to suppress metastasis, invasion and migration of cancer cells. It is regulated under stress conditions such as starvation or hypoxia. NDRG1 regulation is both induced and controlled by HIF-1α-dependent and -independent pathways under hypoxic conditions. However, there are profound differences in the way NDRG1 expression is regulated by HIF-1α and other transcription factors. Therefore, we aimed to define the time-dependent pattern of NDRG1 mRNA and protein expression in human glioblastoma cell lines in extreme hypoxia and after re-oxygenation as well as under normoxic conditions. Furthermore, we ascribe the regulation of NDRG1 to the transcription factors HIF-1α, SP1, CEBPα, YB-1 and Smad7 in a time-dependent manner. The human malignant glioma cell lines U87-MG, U373 and GaMG were cultured for 1, 6 and 24 h under hypoxic (0.1% O2) conditions and then they were re-oxygenated. The mRNA expression of NDRG1, HIF-1α SP1, CEBPα, YB-1 and Smad7 was measured using semi-quantitative RT-PCR analysis. Their protein expression was analyzed using western blotting. Our experiments revealed that long-term (24 h), but not short-term hypoxia led to the induction of NDRG1 expression in human glioma cell lines. NDRG1 expression was found to correlate with the protein expression of HIF-1α, SP1, CEBPα, YB-1 and Smad7. The present study suggests for the first time that SP1 regulates NDRG1 expression in glioma cells under hypoxia in a time-dependent manner along with HIF-1α, CEBPα, YB-1 and Smad7. These molecules, each separately or in combination, may possess the potential to become target molecules for antitumor therapeutic approaches particularly in human brain tumors.
Risk factors for development of postoperative hypertension (2001)

One hundred and eighty-nine patients who underwent digestive tract surgery were studied to investigate risk factors for the development of postoperative hypertension. We examined factors related to maximum postoperative systolic blood pressure and postoperative hypertensive urgency, a sign of postoperative hypertension. Data collected included blood pressure, age, sex, body mass index (BMI), medical history, total water balance and grade of surgical stress. Maximum postoperative systolic blood pressure and incidence of postoperative hypertensive urgency were the dependent variables. Mean preoperative systolic blood pressure, age and BMI were significantly related to maximum postoperative systolic blood pressure and postoperative hypertensive urgency. In addition, the grade of surgical stress was significantly related to maximum postoperative systolic blood pressure. In analyses of multiple variables, the adjusted odds ratio for postoperative hypertensive urgency was 1.16 for every 1 mmHg increase in mean preoperative systolic blood pressure, 1.05 for every 1 year increase in age and 0.82 for every 1 kg/m2 increase in BMI. These findings may have important clinical implications for the prevention of postoperative hypertension.
Correlations between Emotion Regulation, Learning Performance, and Cortical Activity (2007)

While much has been made about the various concepts of emotional regulation in recent psychological literature, little published literature explores the possible relationships between emotional regulation and adult learning
ChemInform Abstract: New Strategy for the Synthesis of N‐Aryl Pyrroles: Cu‐Catalyzed C—N Cross‐Coupling Reaction of trans‐4‐Hydroxy‐L‐proline with Aryl Halides. (2011)

Abstract It is demonstrated that amino acid (I) is an efficient nucleophilic coupling partner in the reaction with aryl iodides and bromides.
Low SO2 emission from CFB co-firing MSW and bituminous. (2004)

Influence of co-firing rate on SO2 emission from co-firing municipal solid waste (MSW) and bituminous containing high amount of sulfur (1.79%) was studied in a 0.15 MWt circulating fluidized bed (CFB). The temperature selected is 1123 K, typical for MSW incineration using CFB. The particle concentration in the dilution zone of the furnace, the alkali metal concentration and sulfate concentration in the recirculating ash and fly ash, and flue gas composition were determined. The results showed that the addition of MSW leads to a significant decrease in SO2 emission. Concentration of SO2 in flue gas decreased to 0 with the co-firing rate greater than 51%. This reduction in SO2 emission is attributed both to the high particle concentration in the dilution zone of the furnace, the high content of alkali metals in the bed material, and to the comparatively high concentration of HCI in flue gas during co-firing of MSW and bituminous.
Sodium MRI in human heart: a review (2015)

This paper offers a critical review of the properties, methods and potential clinical application of sodium ((23)Na) MRI in human heart. Because the tissue sodium concentration (TSC) in heart is about ~40 µmol/g wet weight, and the (23)Na gyromagnetic ratio and sensitivity are respectively about one-quarter and one-11th of that of hydrogen ((1)H), the signal-to-noise ratio of (23)Na MRI in the heart is about one-6000th of that of conventional cardiac (1)H MRI. In addition, as a quadrupolar nucleus, (23)Na exhibits ultra-short and multi-component relaxation behavior (T1 ~ 30 ms; T2 ~ 0.5-4 ms and 12-20 ms), which requires fast, specialized, ultra-short echo-time MRI sequences, especially for quantifying TSC. Cardiac (23)Na MRI studies from 1.5 to 7 T measure a volume-weighted sum of intra- and extra-cellular components present at cytosolic concentrations of 10-15 mM and 135-150 mM in healthy tissue, respectively, at a spatial resolution of about 0.1-1 ml in 10 min or so. Currently, intra- and extra-cellular sodium cannot be unambiguously resolved without the use of potentially toxic shift reagents. Nevertheless, increases in TSC attributable to an influx of intra-cellular sodium and/or increased extra-cellular volume have been demonstrated in human myocardial infarction consistent with prior animal studies, and arguably might also be seen in future studies of ischemia and cardiomyopathies--especially those involving defects in sodium transport. While technical implementation remains a hurdle, a central question for clinical use is whether cardiac (23)Na MRI can deliver useful information unobtainable by other more convenient methods, including (1)H MRI.
An 81‐in. 8 K OLED Kawara‐type multidisplay with flexible displays that provides a seamless image (2015)

Abstract We fabricated a Kawara‐type multidisplay, providing a seamless image by precisely arranging 13.5‐in. organic light‐emitting diode flexible panels with transparent edges on two adjacent sides. To make overlapping portions less visible, the transparent regions were adjusted optically and corrected in luminance and chromaticity. We used 36 panels to fabricate an 81‐in. 8 K organic light‐emitting diode Kawara‐type multidisplay.
Outdoor experimental comparison of four ad hoc routing algorithms (2004)

Most comparisons of wireless ad hoc routing algorithms involve simulated or indoor trial runs, or outdoor runs with only a small number of nodes, potentially leading to an incorrect picture of algorithm performance. In this paper, we report on an outdoor comparison of four different routing algorithms, APRL, AODV, ODMRP, and STARA, running on top of thirty-three 802.11-enabled laptops moving randomly through an athletic field. This comparison provides insight into the behavior of ad hoc routing algorithms at larger real-world scales than have been considered so far. In addition, we compare the outdoor results with both indoor ("tabletop") and simulation results for the same algorithms, examining the differences between the indoor results and the outdoor reality. Finally, we describe the software infrastructure that allowed us to implement the ad hoc routing algorithms in a comparable way, and use the same codebase for indoor, outdoor, and simulated trial runs.
ChemInform Abstract: Stereoisomerism in 3‐[N‐(2‐Acetoxypropanoyl)‐N‐acylamino]quinazolin‐4(3H)‐ones, Enantioselective Acylating Agents. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Basic Design Concept of a Microreactor for Isothermal Operation Including Heat Conductivity (2013)

Abstract A method for designing microreactors for isothermal operation with multiple highly exothermic or endothermic reactions under the conditions of fluid flow in a laminar flow state between two parallel plates is discussed. The formulated design procedure is based on a correlation between the fluid conditions and the heat properties; the operational conditions required for, e.g., a desired heat removal rate can be observed using the provided contour charts. The applicability of the proposed design method was verified using computational fluid dynamics simulations. In addition, the superiority of the microreactors is discussed specifically on the basis of the knowledge from the created charts.
GAS TURBINE FAST REACTOR DESIGN. (1969)

<b>Objective:</b>To remove the immune function of children with obstructive sleep apnea hypopnea syndrome by resection of adenoids and tonsillar. <b>Method:</b> The fasting peripheral venous blood of children with OSAHS and healthy children were collected. The lymphocyte subsets, NK cells and immunoglobulin levels were compared between the two groups. The fasting blood samples of OSAHS children were collected again after 2d, 30d, 60d and 90d after operation. The changes of lymphocyte subsets, NK cells and immunoglobulin levels were observed after operation. <b>Result:</b> Before operation, at the 0.05 test level, it was not yet clear that the levels of IgG, IgM, IgA, NK, CD3+, CD4+ and CD8+ in OSAHS children were significantly different from those in the control group. The levels of IgA, CD3+ and CD4+ decreased significantly in children at 2d and OSAHS after operation, and IgG, IgM, IgA, NK, CD3+ and IgA continued to rise after 60d until ninetieth day after operation. <b>Conclusion:</b> There is no statistical disorder of immune level in children with OSAHS compared with healthy children. The implementation of adenoidectomy and tonsillectomy in children with OSAHS, the level of immunity in 90 days can be restored to the preoperative level.
Task-independent effects are potential confounders in longitudinal imaging studies of learning in schizophrenia (2015)

Learning impairment is a core deficit in schizophrenia that impacts on real-world functioning and yet, elucidating its underlying neural basis remains a challenge. A key issue when interpreting learning-task experiments is that task-independent changes may confound interpretation of task-related signal changes in neuroimaging studies. The nature of these task-independent changes in schizophrenia is unknown. Therefore, we examined task-independent "time effects" in a group of participants with schizophrenia contrasted with healthy participants in a longitudinal fMRI learning-experiment designed to allow for examination of non-specific effects of time. Flanking the learning portions of the experiment with a task-of-no-interest allowed us to extract task-independent BOLD changes. Task-independent effects occurred in both groups, but were more robust in the schizophrenia group. There was a significant interaction effect between group and time in a distributed activity pattern that included inferior and superior temporal regions, frontal areas (left anterior insula and superior medial gyri), and parietal areas (posterior cingulate cortices and precuneus). This pattern showed task-independent linear decrease in BOLD amplitude over the two scanning sessions for the schizophrenia group, but showed either opposite effect or no activity changes for the control group. There was a trend towards a correlation between task-independent effects and the presence of more negative symptoms in the schizophrenia group. The strong interaction between group and time suggests that both the scanning experience as a whole and the transition between task-types evokes a different response in persons with schizophrenia and may confound interpretation of learning-related longitudinal imaging experiments if not explicitly considered.
Supplemental Methods and Table S1 and Figures S1-S5 from IMMU-140, a Novel SN-38 Antibody–Drug Conjugate Targeting HLA-DR, Mediates Dual Cytotoxic Effects in Hematologic Cancers and Malignant Melanoma (2023)

&lt;p&gt;Supplemental Data Table S1. Area under the curve comparisons between IMMU-140 treated A-375 melanoma-bearing mice and all other treatment groups; Fig. S1. Synthesis Scheme for CL2A-SN-38; Fig. S2. Fluorescent Images of A-375 Spheroids Stained with PI and Calcein AM; Fig. S3. Survival Curves of IMMU-140 versus IMMU-114 Treatment of Disseminated Xenograft Disease Models of Human ALL, AML, MM, and CLL; Fig. S4. Tolerability of IMMU-140 Combined with Doxorubicin or Bortezomib in SCID Mice; Fig. S5. HLA-DR a-Chain Expression on Hematological Cancer Xenografts.&lt;/p&gt;
A Comprehensive Hematologic Study in Calves With Total Artificial Hearts (1995)

Thromboembolism and infection remain potential threats for long-term circulatory assist and replacement devices. The alteration of the hemostatic system and of blood cell functions caused by device implantation may predispose the recipient to these complications. Many sensitive coagulation assays and the technology of flow cytometry would be powerful tools for this investigation. The availability of such immunologic technologies for animal species other than humans has yet to be established. In a series of in vitro tests we found that the following assays, among others, are usable in calves: TAT, TxB2, platelet surface glycoprotein IIbIIIa, and membrane aminophospholipid. F1.2, D-dimer, beta TG, PF-4, and platelet surface expression of GMP-140 and receptors for fibronectin, thrombospondin, and vWF were not measurable. A sustained mild decrease in hematocrit levels in six calves with the Cleveland Clinic-Nimbus total artificial heart for 11-120 days was attributed to an increase in circulating blood volume, but not to red blood cell damage. Whole blood platelet aggregation was suppressed only for the first 3 post operative days, with decreased GPIIbIIIa expression. Polymorphonuclear phagocytosis, chemotaxis, and superoxide anion production were not altered. Device infection and thromboembolism occurred in one of 13 cases overall.
Activation of erbium films for hydrogen storage (2011)

Hydriding of metals can be routinely performed at high temperature in a rich hydrogen atmosphere. Prior to the hydrogen loading process, a thermal activation procedure is required to promote facile hydrogen sorption into the metal. Despite the wide spread utilization of this activation procedure, little is known about the chemical and electronic changes that occur during activation and how this thermal pretreatment leads to increased rates of hydrogen uptake. This study utilized variable kinetic energy X-ray photoelectron spectroscopy to interrogate the changes during in situ thermal annealing of erbium films, with results confirmed by time-of-flight secondary ion mass spectrometry and low energy ion scattering. Activation can be identified by a large increase in photoemission between the valence band edge and the Fermi level and appears to occur over a two stage process. The first stage involves desorption of contaminants and recrystallization of the oxide, initially impeding hydrogen loading. Further heating overcomes the first stage and leads to degradation of the passive surface oxide leading to a bulk film more accessible for hydrogen loading.
Resistance to Quorum-Quenching Compounds (2013)

Bacteria have the remarkable ability to communicate as a group in what has become known as quorum sensing (QS), and this trait has been associated with important bacterial phenotypes, such as virulence and biofilm formation. Bacteria also have an incredible ability to evolve resistance to all known antimicrobials. Hence, although inhibition of QS has been hailed as a means to reduce virulence in a manner that is impervious to bacterial resistance mechanisms, this approach is unlikely to be a panacea. Here we review the evidence that bacteria can evolve resistance to quorum-quenching compounds.
Novel Germline PTEN Mutation Associated with Cowden Syndrome and Osteosarcoma (2018)

We report a patient with CS presenting with ganglioneuromatosis, benign breast mass and osteosarcoma, harboring a novel molecular alteration in PTEN which to our knowledge has not been previously reported.
Supplementary Figures S1-S3 from Prognostic Significance of Macrophage Infiltration in Leiomyosarcomas (2023)

Supplementary Figures S1-S3 from Prognostic Significance of Macrophage Infiltration in Leiomyosarcomas