gebhart/patrepeval huggingface dataset:
Effects of Monoclonal Antibodies to Specific Epitopes of Rat Interleukin‐1 Beta (IL‐Iβ) on IL‐1β‐Induced ACTH, Corticosterone and IL‐6 Responses in Rats (1995)

Recently, we developed a panel of monoclonal antibodies (MoAbs) to rat IL-1 beta and found that MoAbs binding to the aminoacid sequences 66-85 and 123-143 of mature rIL-1 beta inhibited the binding of rIL-1 beta to murine EL4 cells. Here we study whether MoAbs to these and other domains of IL-1 interfere with the biological effects of rIL-1 beta in adult male rats in vivo. Administration of rIL-1 beta (1 or 5 micrograms/kg i.v.) enhanced the plasma concentrations of ACTH, corticosterone (CORT) and of IL-6 in a time- (0.5-4 h) and dose-dependent manner. Because 2 h after 5 micrograms/kg i.v., all three parameters were consistently elevated, this dose and time interval was used for further studies. Prior to injection, rIL-1 beta was incubated alone or in the presence of a MoAb (10 mg/kg) for 30 min at 37 degrees C or at 4 degrees C. Plasma ACTH, CORT and IL-6 responses to these mixtures are compared to those obtained after preincubation of rIL-1 beta with a non-IL-1 binding MoAb (PEN7). SILK 3, a MoAb that binds to the 66-85 domain of rIL-1 beta, reduced the ACTH and IL-6 responses by 48 and 45% respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
Supplementary Test from PET Imaging of TIGIT Expression on Tumor-Infiltrating Lymphocytes (2023)

&lt;p&gt;Supplementary information&lt;/p&gt;
Enzymatic Degradation of <i>Bombyx mori</i> Silk Materials: A Review (2020)

As a biomaterial, silk presents unique features with a combination of excellent mechanical properties, biocompatibility, and biodegradability. The biodegradability aspects of silk biomaterials, especially with options to control the rate from short (days) to long (years) time frames in vivo, make this protein-based biopolymer a good candidate for developing biodegradable devices used for tissue repairs and tissue engineering, as well as medical device implants. Silk materials, including native silk fibers and a broad spectrum of regenerated silk materials, have been investigated in vitro and in vivo to demonstrate degradation by proteolytic enzymes. In this Review, we summarize the findings on these studies on the enzymatic degradation of <i>Bombyx mori</i> (<i>B. mori</i>) silk materials. We also present a discussion on the factors that dictate the degradation properties of silk materials. Finally, in future perspectives, we highlight some key challenges and potential directions toward the future study of the degradation of silk materials.
Transmission Loss and Absorption of Corrugated Core Sandwich Panels With Embedded Resonators (2014)

The effect of embedded resonators on the diffuse field sound transmission loss and absorption of composite corrugated core sandwich panels has been evaluated experimentally. Two 1.219 m × 2.438 m panels with embedded resonator arrangements targeting frequencies near 100 Hz were evaluated using non-standard processing of ASTM E90-09 acoustic transmission loss and ASTM C423-09a room absorption test measurements. Each panel is comprised of two composite face sheets sandwiching a corrugated core with a trapezoidal cross section. When inlet openings are introduced in one face sheet, the chambers within the core can be used as embedded acoustic resonators. Changes to the inlet and chamber partition locations allow this type of structure to be tuned for targeted spectrum passive noise control. Because the core chambers are aligned with the plane of the panel, the resonators can be tuned for low frequencies without compromising the sandwich panel construction, which is typically sized to meet static load requirements. Absorption and transmission loss performance improvements attributed to opening the inlets were apparent for some configurations and inconclusive for others.
Dipole magnetics: Using low frequency controlled-source EM to map magnetic anomalies (2013)

In this paper we will look at a variation of Earth’s field magnetics we call “dipole magnetics”. That is, using a low frequency controlled source in combination with oriented magnetic field receivers to prospect for magnetic objects. Using a low frequency portable EM source, targets can be illuminated from a variety of positions, angles and polarizations. This allows for much improved imaging, the elimination of remnant magnetization and the possibility of repetitive signal averaging. The disadvantages are that the source needs to be provided and in some cases inductive effects need to be considered. The technique has an analogy to DC resistivity from a dipolar electrical source. The same mathematics and forward solutions can be applied and existing DC resistivity software could be used, with minor adjustments, to image targets of interest. In areas of higher conductivity or at higher frequencies inductive affects are significant and a full EM solution must be applied. The utility of this method will be in better defining clear magnetic anomalies and in identifying more subtle anomalies, not evident it earth's field magnetics.
A concept for monolithic shape memory alloy micro-devices (1997)

Most of Shape Memory Alloy (SMA) devices use only the SMA material as the actuating part or in some cases as the flexible part of the device (superelastic hinges). Commonly, simple wires, strips or springs are used for the actuating part. All these systems need an assembly procedure which raises several problems in the micro-system field : careful assembly, sometimes friction, .... The concept of monolithic SMA micro-devices presented in this paper is to integrate all functions of the device within the same material. For example, in a micro-gripper, the jaws and the moving part are made out of the same piece of material. With this technology, we avoid any assembly in the small dimensions. Moreover sub-millimeter devices can easily be designed and further miniaturization can be achieved. As an illustration, two micro-devices based on this concept are presented.
A novel image cytometric analysis method for T cell-mediated cytotoxicity of 3D tumor spheroids (2017)

Abstract Cell-mediated cytotoxicity assays have been frequently performed to characterize cytotoxic potential of immune cells, antibodies, and drug compounds. Traditionally, these assays are performed using release assays such as Cr51 (radioactivity), Calcein (fluorescence), or LDH (enzymatic). However, release assays have limitations such as the handling of hazardous material and the indirect measurement of cell death. These assays are commonly performed in 2D cultures, which have difficulty identifying qualifying drug candidates for clinical testing, thus there has been an interest of performing cytotoxicity assays in 3D tumor models. Traditional 3D spheroid analysis methods require the use of standard microscopy, which is time-consuming and subjective. In this work, we demonstrate a novel method of analyzing T cell-mediated cytotoxicity on 3D tumor spheroids in the presence of absence of ImmTAC molecules, which can promote higher T cell killing. In this experiment, MDA-MB-453 GFP expressing breast cancer cells are used to form tumor spheroids in an ultra-low attachment plate. The spheroids are then treated with primary T cells at different E:T ratios, and different concentrations of ImmTAC. The results showed a dose response effect of T cell killing with the addition of ImmTAC molecules by measuring spheroid size in GFP fluorescence and viability using propidium iodide. The captured bright-field and fluorescent images also clearly showed the cytotoxicity effect from the combination of T cells and ImmTAC. The ability to screen cytotoxic effects of immune cells, antibody, and drug compounds on 3D tumor spheroids can provide an alternative tumor model for identifying more qualified cancer drug candidates for drug discovery campaigns.
Untersuchung der luftreinigenden Wirkung einer temperierten Wasserwand in Innenräumen hinsichtlich Feinstaub PM <sub>10</sub> (2018)

Abstract Zum Zwecke der Raumluftkonditionierung wurde am Fraunhofer‐Institut für Bauphysik IBP ein vertikales Flächenelement entwickelt, über das temperiertes Wasser fließt. Da es sich bei diesem Element um eine Art Zimmerbrunnen handelt, der die Raumluft sowohl kühlt als auch be‐ oder entfeuchtet, wird diese Anlage auch als Klimabrunnen bezeichnet. Aufgrund von Beobachtungen besteht die Vermutung, dass dieser Klimabrunnen auch in der Lage ist, die umgebende Luft von Fremdpartikeln zu reinigen. Am Beispiel von Feinstaub der Größe PM 10 wurde daher mithilfe eines Grimm‐Messgerätes untersucht, wie sich eine einmalig eingebrachte Feinstaubmenge vor dem Klimabrunnen verhält und welchen Einfluss die Wassertemperatur auf den zeitlichen Verlauf der Schadstoffkonzentration hat. Die Auswertung der Messergebnisse zeigt einen beachtlichen Zusammenhang zwischen Wassertemperatur und Abnahmegeschwindigkeit der Feinstaubmenge in der Luft. Ein auf 7 °C gekühlter Klimabrunnen schafft es, die PM 10 ‐Konzentration ausgehend von 200 µg/m 3 rund 21 Minuten schneller unter den gesetzlichen Grenzwert von 50 µg/m 3 zu senken als ein ungekühlter Klimabrunnen. Die Reduktion auf unter ein Prozent der Startmenge geschieht sogar über eine Stunde schneller. Dabei spielt nachweislich die Luftzirkulation eine bedeutende Rolle, die aufgrund von Konvektion infolge der Temperaturunterschiede an der Grenzschicht zwischen Wasser und Raumluft entsteht. Hier zeigt sich ein klarer Vorteil des Klimabrunnens gegenüber ungekühlten Wasserwänden.
Branching of Microvilli in the Human Conjunctival Epithelium (1980)

Biopsy specimens were obtained from the upper tarsal and limbal conjunctivae of ten normal persons and from the upper tarsal conjunctivae of five asymptomatic contact lens wearers and five patients with giant papillary conjunctivitis (GPC) associated with contact lens wear. The microvillar surface of the conjunctival epithelium was studied by transmission and scanning electron microscopy. Branches often stemmed from the side of a straight tubular microvillus and formed an acute angle with the main process. Branches sprouted at various distances from the origin of the microvillus. The most common branching pattern was the bifurcated (bifid) form. Occasionally, both primary and secondary bifurcations were primary and secondary bifurcations were observed on the same microvillus. Some microvilli were branched in the normal conjunctivae, but the conjunctivae of asymptomatic contact lens wearers and patients with GPC had more branched microvilli and greater polymorphism, which correlated with the degree of alteration. This report demonstrates the presence of branched microvilli and describes the types seen in normal conjunctivae and compares the frequency with which branched microvilli are seen in altered conjunctival surfaces.
Electro-Conversion of Renewables Originating from Waste Streams of the Pulping Process (2017)

The electrochemical conversion of biomass which does not compete with nutrition purposes represents an attractive field of research. In particular, waste streams that usually only employed for incineration can be used to make value-added chemicals, this approach is of interest in terms of ecological and economic aspects. In the pulping process, the major biomass by-products are lignin, tall oil, and turpentine fraction. The presentation deals with the selective electrochemical conversion of lignin to vanillin and diacids from turpentine fraction. Besides the electrochemical process, also valid work-up protocols are outlined.
Superconductivity in 1111-type CaFeAsF1-xHx induced by selective hydrogen elimination (2013)

The difference in thermal stability of F- and H- in 1111-type iron based superconductors, allows selective hydrogen elimination from non-superconductive CaFeAsF0.8H0.2 by thermal annealing. The analyzed chemical composition of the resulting samples indicates that incorporated hydrogen was selectively eliminated by thermal annealing at 553 K for 72 hours. The resulting hydrogen-eliminated sample shows bulk superconductivity with Tc = 29 K. This technique may be used for indirect electron doping for AeFeAeF (Ae; alkali-earth metal) iron based superconductor described by CaFeAsF1-xHx =&gt; CaFeAsF1-x + xe- + 1/2xH2.
Time-lapse full-waveform inversion for cross-well monitoring of microbubble injection (2017)

Seismic monitoring is increasingly important to understand time-varying changes in subsurface physical properties for hydrocarbon production, CO2 geosequestration, and near-surface engineering purposes. Since the resulting changes in elastic parameters and then in recorded seismic waveforms tend to be small, full waveform inversion (FWI) can be a powerful method to accurately estimate time-lapse velocity changes by maximizing the use of waveform information. We apply time-lapse FWI to cross-well survey data acquired with highly repeatable pseudo-random sources to monitor microbubble injection into shallow unconsolidated sediments. We use parallel time-lapse inversion, and successfully detect very small time-lapse velocity changes (<1 %) within a thin layer (< 1m) due to highly repeatable data sets, careful data preprocessing, and well-designed inversion procedures. The velocity changes indicate the potential influence of the fluvial depositional environment on the migration of injected microbubble water. Presentation Date: Wednesday, September 27, 2017 Start Time: 11:00 AM Location: 361F Presentation Type: ORAL
Nanometer–Nanosecond Oscillatory Expansion and Contraction Behavior of Polymer Films Induced by 248 nm Excimer Laser Excitation (2000)

Microregional mechanical measurements of a poly[methylmethacrylate) film can be made by a combined probe/measurement laser system, as represented in the picture. The localized nature of the laser systems allow quantification of the degree of expansion and contraction processes, as well as the glass–rubber transition. Such nondestructive techniques lead to the elucidation of polymer morphological dynamics.
Single transducer for measurement of small displacements or forces (2014)

Introduction: One of the limits to characterization of tissues at the microscopic level is the substantial costs associated with the instrumentation required for such investigations. The use of strain gages for displacement or force measurements can be adapted to this microscopic scale provided the gages are incorporated into a transducer consisting of a curved geometry. Materials and Methods: Uniaxial strain gages 13 mm (L) × 6 mm (W) were secured to 0.2-mm thick brass shim stock fabricated to yield a 12.5-mm diameter semicircle with mounting tabs on either end. The terminal ends of the strain gage mounting pads were connected to an adjustable strain gage amplifier with adjustable gain and offset. For displacement calibration, the transducer was secured to the jaws of a digital caliper. Caliper displacement was set to ±0.25 mm increments from 0 to a maximum of ±1.5 mm. In this configuration, positive represents tension. Amplifier Gains were set to 500, 1000, and 5000 to observe nonlinearity. For each of three displacement calibration runs, output voltage from the transducer was recorded at each distance with the mean output at absolute distances averaged across each of three runs for each of six transducers. Using the same transducers, a mass balance was used to identify the unique individual mass associated with a total of 10 masses to within ±10 μg. The masses were sequentially secured to the transducer and the respective output voltage recorded. Amplifier Gains were set to 500, 1000 and 5000. For each of three force calibration runs, output voltage from the transducer was recorded with respect to the force generated by the suspended masses. The mean output across each of three runs for each of six transducers was subjected to linear regression. Results and Discussion: All transducers displayed good linearity when calibrated for displacement with regression R2 values of 0.9994, 0.9967, and 0.9941 for amplifier gains of 500, 1000, and 5000, respectively. Further, in displacement mode, the transducers provided a mean output of 0.66, 1.01, and 3.86 V/mm at amplifier gains of 500, 1000, and 5000, respectively. In force mode, regression R2 in excess of 0.9995 were observed over all amplifier gain settings examined. When employed as force transducers, the devices provided mean outputs of 0.60, 1.15, and 5.85 V/N at amplifier gains of 500, 1000, and 5000, respectively. The response of these devices to either applied displacement or force permits the use of a single device type to be used as either a displacement or force transducer. The electrical output in either mode at modest amplification gains of 5000 combined with excellent linearity affords the use of these devices for studies where characterization of tissues requires mN and μm level resolution. Conclusions: A transducer employing a strain gage had been configured so as to function as either a displacement or force measuring instrument. The resulting device displays high linearity and electrical output even at modest amplifier gains.
Analysis of the Government from the Perspective of the Healthy Development of Real Estate (2010)

With the continuing development of market economy,China's real estate industry has gained its recognized achievement.At the same time,it also has problems such as structural contradictions in housing,housing prices rose too fast and the loss of the real estate market behavior etc.Chinese government,as the main guide of socio-economic development,should make a positive and effective response on these issues with policy guidance,rational macro-control and rigorous means of regular market confusion,so to promote the healthy development of the domestic real estate industry.
Liquid-chromatographic determination of cimetidine, its known metabolites, and creatinine in serum and urine. (1981)

We describe a liquid-chromatographic procedure for determination of cimetidine, its hydroxymethyl-, sulfoxide-, and guanyl urea metabolites, and creatinine in patients serum and urine. SKF 92374 is used as the internal standard. Protein in 0.5 mL of serum or diluted urine is precipitated with 2 mL of acetonitrile, the organic and aqueous phases are separated by adding 0.3-0.5 g of anhydrous K2HPO4. The organic phase is evaporated, and 0.5 mL of 50 mmol/L HCl is added. This solution is washed with 3 mL of water-saturated isoamyl alcohol, the aqueous phase is extracted with 3 mL of methylene chloride and enough K2HPO4 to saturate the solution. The methylene chloride is evaporated, the residue reconstituted with 100 microL of mobile phase, and a 25-microL aliquot injected onto the chromatographic column (Dupont Sil). The mobile phase is acetonitrile/methanol/water/ammonium hydroxide (1000/50/50/2, by vol). The column effluent is monitored at 228 nm. Lower limits of detection ranged from 0.05 mg/L for cimetidine to 0.2 mg/L for guanyl urea. We determined cimetidine and its principal metabolites in the serum of a patient receiving cimetidine for the treatment of Zollinger-Ellison syndrome, and have assessed use of the assay in a clinical setting.
Compensation effect in electrical conductivity of poly(ε-caprolactam) containing variable amount of lithium chloride (2002)

The DC electrical conductivity of poly(/spl epsiv/-caprolactam) containing LiCl is investigated as a function of time, temperature and salt content. Experimental evidence of compensation effect for conductivity of specimens containing different amounts of LiCl is shown. A not-monotone behavior of conductivity with salt content is pointed out.
Interaction Forces of Soft Fiber Reinforced Bending Actuators (2016)

Soft-bending actuators are inherently compliant, compact, and lightweight. They are preferable candidates over rigid actuators for robotic applications ranging from physical human interaction to delicate object manipulation. However, characterizing and predicting their behaviors are challenging due to the material nonlinearities and the complex motions they can produce. This paper investigates a soft-bending actuator design that uses a single air chamber and fiber reinforcements. Additionally, the actuator design incorporates a sensing layer to enable real-time bending angle measurement for analysis and control. In order to study the bending and force exertion characteristics when interacting with the environment, a quasi-static analytical model is developed based on the bending moments generated from the applied internal pressure and stretches of the soft materials. Comparatively, a finite-element method model is created for the same actuator design. Both the analytical model and the finite-element model are used in the fiber reinforcement analysis and the validation experiments with fabricated actuators. The experimental results demonstrate that the analytical model captures the relationships of supplied air pressure, actuator bending angle, and interaction force at the actuator tip. Moreover, it is shown that an off-the-shelf bend angle sensor integrated to the actuator in this study could provide real-time force estimation, thus eliminating the need for a force sensor.
In Vitro Interactions between Peripheral Blood Lymphocytes and the Wong-Kilbourne Derivative of Chang Conjunctival Cells (2012)

These results suggest that the in vitro interaction of PBLs with WKD cells participates in BAC-induced epithelial toxicity regulation, probably through cell membrane contacts.
Guest Editorial (2007)

The thirty-four papers in this special issue were presented at the 2007 IEEE International Microwave Symposium held in Honolulu, HI, June 2007.
ChemInform Abstract: NITRATION OF THE LITHIUM POTASSIUM DIANIONS OF PHENOLIC ALKYL ARYL KETONES WITH PROPYL NITRATE: SYNTHESIS OF 1‐NITROALKYL HYDROXYPHENYL KETONES (1982)

Abstract HydroxyphenyI‐alkylketone (I) werden zunächst in Lithiumphenolute und danach in Knliumenolate (II) ′Libergeführt, die mit Propylnitrat (III) I‐Nitro21IkyI‐hydroxyphenylketone (IV) bilden.
GENERATION-RECOMBINATION AND 1/f NOISE IN <font>Al</font><sub>0.4</sub><font>Ga</font><sub>0.6</sub><font>N</font> THIN FILMS (2002)

Low-frequency noise in Al 0.4 Ga 0.6 N thin films (50 nm) was measured at room and elevated temperatures as function of gate and drain voltages. Both 1/f noise and generation-recombination noise were observed. Hooge parameter, α, was estimated to be about 7. The activation energy for observed generation-recombination noise was found to be E a ~ 1.0 eV . This activation energy is consistent with the activation energy observed for g-r noise in AlGaN/GaN HFETs.
Performance analysis of MNMR state estimator considering PMU data (2012)

The MNMR state estimator for power system, based on the theory of uncertainty, has a good performance of robustness. However, the PMU data, as an indispensable measurement in modern power system, is not applied to the MNMR estimator explicitly. In this paper, the impact of PMU data on the robustness and precision of MNMR estimator is analyzed theoretically. Then, the PMU data of voltage phasor, voltage and current phasor are introduced respectively and the performance of MNMR estimator is investigated. Meanwhile, in the case of considering the PMU data of voltage and current phasor, the impact of zero-current injection constraints on MNMR estimator is analyzed. Simulation results show that the precision of MNMR estimator is improved by taking account of the zero-current injection constraints. Furthermore, the introduction of PMU data can improve the precision and robustness of MNMR estimator effectively. (5 pages)