gebhart/patrepeval huggingface dataset:
Spectral kurtosis statistics of quantized signals (2016)

We investigate the bias of the Spectral Kurtosis Estimator induced by the quantization and bit truncation of the accumulated spectral power, which are standard signal manipulation operations performed by radio astronomy instruments that produce Power Spectral Density (PSD) estimates by means of sequential Discret Fourier Transform (DFT) operations. We demonstrate that these bias may be properly accounted for by adjusting the shape parameter of the Gamma distribution according to which the accumulated PSD estimates are expected to be distributed without quantization. To demonstrate the validity of this approach, we test the performance of an empirically tuned SK estimator using 2-bit auto-correlation data produced by the Parkes telescope.
TOPOLOGY ANALYSIS OF DRUG BINDING SITES ON HUMAN SERUM ALBUMIN USING SITE-DIRECTED MUTAGENESIS (2000)

Recombinant wild-type and mutant human serum albumins were produced using a yeast expression system. We investigated, by ultrafiltration, the high affinity binding of two representative site II-ligands, namely ketoprofen(KP) and diazepam(DZ). According to the crystal structure of HSA, the residues of 410Arg and 411Tyr protrude into the center of site II (in subdomain 3A), and the binding results showed that the guanidino moiety of 410Arg the phenolic oxygen and the aromatic ring of 411Tyr are important for KP binding. The guanidino moiety probably interacts electrostatically with the carboxyl group of KP, the phenolic oxygen could make a hydrogen-bond to the ketogroup of the ligand, and the aromatic ring may participate in a specific stacking interaction with one of or both of the aromatic rings of KP. By contrast, 410Arg is not important for DZ binding. In addition to its unique ligand binding properties, HSA also possesses an esterase-like activity, and studies with p-nitrophenyl acetate as a substrate showed that although 410Arg is important, the enzymatic activity of albumin is much more dependent on the presence of 411Tyr. In order to characterize the warfarin (WF) binding site, 199Lys, 214Trp, 218Arg and 242His were mutated. At pH 7.4, the affinity of H242Q and K199A were found to be about 6 and 4 times higher as compared to that of wild-type HSA, respectively. However, the affinity of R218H and W214A for WF were about 3 and 2 times reduced.These results show that the side chain of 214Trp and 218Arg are important for WF binding. In contrast, t he side chains of 199Lys and 242His interfere with binding. Finally, the effect of the N-B transition on WF binding will be discussed.
Production of <i>trans</i> ‐Free Margarine with Stearidonic Acid Soybean and High‐Stearate Soybean Oils‐Based Structured Lipid (2012)

The current research increases the food applications of stearidonic acid (SDA) soybean oil. trans-Free SDA containing SL was synthesized with desirable polymorph, thermal properties, and SFC for formulation of soft margarine. The margarine produced with this SL had no trans fat and had a low n-6/n-3 ratio. This may help in reducing trans fat intake in our diet while increasing n-3 FA intake.
Multi-step Time Series Prediction in Complex Instrumented Domains (2010)

Time series prediction algorithms are widely used for applications such as demand forecasting, weather forecasting and many others to make well informed decisions. In this paper, we compare the most prevalent of these methods as well as suggest our own, where the time series are generated from highly complex industrial processes. These time series are non-stationary and the relationships between the various time series vary with time. Given a set of time series from an industrial process, the challenge is to keep predicting a chosen one as far ahead as possible, with the knowledge of the other time series at those instants in time. This scenario occurs, since the chosen time series is usually very expensive to measure or extremely difficult to obtain compared to the rest. Our studies on real data suggest, that our method is substantially more robust to predicting multiple steps ahead than the existing methods in these complex domains.
Integrin β3 Targeting Biomaterial Preferentially Promotes Secretion of bFGF and Proliferation of iPSC-Derived Vascular Smooth Muscle Cells (2021)

Abstract Human-induced pluripotent stem cell-derived-vascular smooth muscle cells (hiPSC-VSMC) have been shown to promote angiogenesis and wound healing. However, there is a paucity of research on how the extracellular matrix (ECM) microenvironment may impact the hiPSC-VSMC’s function. In this study, our objective was to understand the effect of specific ECM ligand-integrin interaction on hiPSC- VSMC’s paracrine secretion, cell proliferation, and morphology. We here showed a precise modulation of hiPSC-VSMC in a fibronectin functionalized fibrillar collagen scaffold by targeting their integrin β3. The secretion of proangiogenic growth factor, basic fibroblast growth factor (bFGF) was found to be fibronectin dependent via αvβ3 integrin interactions. Also, our data indicate the possible role of a positive feedback loop between integrin β3, bFGF, and matrix metalloproteinase-2 in regulating hiPSC- VSMC’s morphology and cell proliferation. Finally, the secretome with improved proangiogenic activity shows potential for future regenerative applications.
Erratum: A mean-field theory of grain boundary segregation [J. Chem. Phys. <b>9</b> <b>5</b>, 4427 (1991)] (1992)

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<i>Oenothera paradoxa</i> Defatted Seeds Extract and Its Bioactive Component Penta-<i>O</i>-galloyl-β-<scp>d</scp>-glucose Decreased Production of Reactive Oxygen Species and Inhibited Release of Leukotriene B<sub>4</sub>, Interleukin-8, Elastase, and Myeloperoxidase in Human Neutrophils (2010)

In this study, we analyzed ex vivo the effect of an aqueous extract of Oenothera paradoxa defatted seeds on the formation of neutrophil-derived oxidants. For defining active compounds, we also tested lypophilic extract constituents such as gallic acid, (+)-catechin, ellagic acid, and penta-O-galloyl-β-D-glucose and a hydrophilic fraction containing polymeric procyanidins. The anti-inflammatory potential of the extract and compounds was tested by determining the release from activated neutrophils of elastase, myeloperoxidase, interleukin-8 (IL-8), and leukotriene B4 (LTB4), which are considered relevant for the pathogenesis of cardiovascular diseases. The extract of O. paradoxa defatted seeds displays potent antioxidant effects against both 4β-phorbol-12β-myristate-α13-acetate- and formyl-met-leu-phenylalanine-induced reactive oxygen species production in neutrophils with IC50 values around 0.2 μg/mL. All types of polyphenolics present in the extract contributed to the extract antioxidant activity. According to their IC50 values, penta-O-galloyl-β-D-glucose was the more potent constituent of the extract. In cell-free assays, we demonstrated that this effect is partially due to the scavenging of O2- and H2O2 oxygen species. The extract and especially penta-O-galloyl-β-D-glucose significantly inhibit elastase, myeloperoxidase IL-8, and LTB4 release with an IC50 for penta-O-galloyl-β-D-glucose of 17±1, 15±1, 6.5±2.5, and around 20 μM, respectively. The inhibition of penta-O-galloyl-β-D-glucose on reactive oxygen species and especially on O2- production, myeloperoxidase, and chemoattractant release may reduce the interaction of polymorphonuclear leukocyte with the vascular endothelium and by that potentially diminish the risk of progression of atherosclerosis development.
Simultaneous Determination of Eight Urinary Metabolites by HPLC-MS/MS for Noninvasive Assessment of Traumatic Brain Injury (2020)

Traumatic brain injury (TBI) is a serious public health concern for which sensitive and objective diagnostic methods remain lacking. While advances in neuroimaging have improved diagnostic capabilities, the complementary use of molecular biomarkers can provide clinicians with additional insight into the nature and severity of TBI. In this study, a panel of eight metabolites involved in distinct pathophysiological processes related to concussion was quantified using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Specifically, the newly developed method can simultaneously determine urinary concentrations of glutamic acid, homovanillic acid, 5-hydroxyindoleacetic acid, methionine sulfoxide, lactic acid, pyruvic acid, <i>N</i>-acetylaspartic acid, and F<sub>2α</sub>-isoprostane without intensive sample preparation or preconcentration. The method was systematically validated to assess sensitivity (method detection limits: 1-20 μg/L), accuracy (81-124% spike recoveries in urine), and reproducibility (relative standard deviation: 4-12%). The method was ultimately applied to a small cohort of urine specimens obtained from healthy college student volunteers. The method presented here provides a new technique to facilitate future work aiming to assess the clinical efficacy of these putative biomarkers for noninvasive assessment of TBI.
Eccentric training with a powered rowing machine (2019)

The aim of this study was to investigate the effects of eccentric workloads generated by a powered rowing machine on the cardiorespiratory, cardiovascular and musculoskeletal systems. It was hypothesized that beneficial physiological effects would result by training with high eccentric workloads. Conventional rowing machines are utilized for performance improvements through concentric workloads alone; however for this research, a conventional machine was modified with an electric motor and an advanced control system to allow the machine to also include eccentric capabilities. The ability to combine concentric and eccentric actions in any exercise has the potential to improve training effectiveness. The study followed an experimental design, exposing ten subjects (5 male, 5 female) to multiple eccentric workloads generated by the powered rowing machine. Each subject participated in two 12-min exercise trials corresponding to full body row (FBR) and low body row (LBR). Each of these trials included four 3-min stages that gradually increased the eccentric workload. Increased eccentric muscle contractions and metabolic cost were confirmed in the experiments. The results on oxygen consumption reveal a significant increase between stages 1 and 2 for both exercises (FBR p=0.0001 and LBR p=0.004) with no significant increases between the remaining stages. Results on heart rate reveal a significantly increase with each stage for both exercises (p<0.05). Results on muscle activation also reveal an overall increase for all muscle groups as eccentric workload is increased.
Changes of plasma hemostatic markers during percutaneous transluminal coronary angioplasty in patients with chronic coronary artery disease (1999)

Changes of hemostatic parameters during percutaneous transluminal coronary angioplasty (PTCA) in 75 patients with chronic coronary artery disease were evaluated. Plasma levels of D-dimer, soluble fibrin monomer, plasmin-alpha2 antiplasmin inhibitor complex, and tissue factor (TF) were significantly increased in all patients with chronic coronary artery disease. The activity of antithrombin and protein C and the levels of protein C antigen were significantly decreased 1 hr after PTCA, but they returned to normal range 1 day after PTCA. There was no significant difference in the level of plasma APC-PCI complex before and 1 hr after PTCA. The plasma levels of D-dimer, soluble fibrin monomer, thrombomodulin, TF and PPIC were significantly decreased 1 hr, and the plasma levels of plasmin-alpha2 antiplasmin inhibitor complex 1 day after PTCA. These findings suggest that the decrease of protein C and antithrombin resulted in activation of the coagulation system. One hour after PTCA, the plasma levels of (total-free) TF pathway inhibitor (TFPI) were significantly decreased, but the plasma levels of total and free-TFPI were significantly increased, suggesting that consumption of (total-free) TFPI occurs during PTCA. Overall, these findings suggest that the hypercoagulable state improves during PTCA and that transient decrease of antithrombin, protein C, (total-free) TFPI or plasmin-alpha2 antiplasmin inhibitor complex may cause restenosis of coronary artery.
ChemInform Abstract: Synthetic and Structural Studies on (η5:η5‐Fulvalene)bimetallic Compounds Derived from (η5:η5‐Fulvalene)dithallium. (1990)

Abstract The air‐sensitive dithallium compound (III) reacts with carbonyl halides of Rh, e.g. (IV), and Co, Ir, Mn, and Re to produce the corresponding homobimetallic fulvalene metal carbonyls (V) ((Va) and (Vb) (M: Mn) both space group P2 1 /c, Z=2; (Vc) (M: Mn) P2 1 /n, Z=2).
Innate Immune Signaling Induces High Levels of TC-specific Deaminase Activity in Primary Monocyte-derived Cells through Expression of APOBEC3A Isoforms (2010)

In HIV-1-infected individuals, G-to-A hypermutation is found in HIV-1 DNA isolated from peripheral blood mononuclear cells (PBMCs). These mutations are thought to result from editing by one or more host enzymes in the APOBEC3 (A3) family of cytidine deaminases, which act on CC (APOBEC3G) and TC (other A3 proteins) dinucleotide motifs in DNA (edited cytidine underlined). Although many A3 proteins display high levels of deaminase activity in model systems, only low levels of A3 deaminase activity have been found in primary cells examined to date. In contrast, here we report high levels of deaminase activity at TC motifs when whole PBMCs or isolated primary monocyte-derived cells were treated with interferon-alpha (IFNalpha) or IFNalpha-inducing toll-like receptor ligands. Induction of TC-specific deaminase activity required new transcription and translation and correlated with the appearance of two APOBEC3A (A3A) isoforms. Knockdown of A3A in monocytes with siRNA abolished TC-specific deaminase activity, confirming that A3A isoforms are responsible for all TC-specific deaminase activity observed. Both A3A isoforms appear to be enzymatically active; moreover, our mutational studies raise the possibility that the smaller isoform results from internal translational initiation. In contrast to the high levels of TC-specific activity observed in IFNalpha-treated monocytes, CC-specific activity remained low in PBMCs, suggesting that A3G deaminase activity is relatively inhibited, unlike that of A3A. Together, these findings suggest that deaminase activity of A3A isoforms in monocytes and macrophages may play an important role in host defense against viruses.
Diffusion-controlled recrystallization and grain growth-induced plasticity of steel under externally applied stress (2008)

Permanent deformation, which occurs during recrystallization and grain growth under an applied stress much smaller than the yield stress of the material, was observed by dilatometric measurement and modelled on the basis of a migrating grain boundary diffusion mechanism. The observation confirmed that the transformation-induced deformation accompanying the interface migration is described by migrating boundary-induced plasticity rather than internal stress caused by volume change and plastic yielding. In the model, atomic diffusion along the migrating grain boundary was assumed to cause recrystallization and grain growth-induced plasticity. A constitutive equation for recrystallization and grain growth-induced plasticity was derived as a function of the grain growth rate, temperature and externally applied stress. The predictions were compared with the dilatometric measurements made during recrystallization and grain growth of an extra low-carbon steel under various levels of uniaxial compressive stress, with good agreement being found between the calculated permanent strain and the experimentally derived strain.
Optimization of Take-off and Landing Maneuvers for a Quad-plane UAV (2021)

This paper designs a flight maneuver that minimizes the battery power consumption during take-off or landing for a Quad-plane UAV (Unmanned Aerial Vehicle), through numerical optimization. The power consumption is calculated from the inverse dynamics and the rotor power model for transition flight between a rotary-wing mode and a fixed-wing mode. In a maneuver designed for landing, the UAV is decelerated due to drag force of a wind-milling propeller.
First time measurement of gamma‐ray excited LaBr<sub>3</sub>:5% Ce<sup>3+</sup> and LaCl<sub>3</sub>:10% Ce<sup>3+</sup> temperature dependent properties (2006)

Abstract We have measured for the first time the temperature dependence of LaBr 3 :5% Ce 3+ and LaCl 3 :10% Ce 3+ gamma‐ray excited light yields and decay curves between 100 and 600 K. Under gamma‐ray excitation, both scintillators present a very good thermal stability over the entire temperature range. The light yield of LaBr 3 is maximum at 100 K and decreases monotonously from 100 to 600 K. The decrease at 600 K does not exceed 15% of the maximum value. The light yield of LaCl 3 is maximum at 600 K and decreases with decreasing temperatures. The lowest value is reached at 150 K and corresponds to 90% of the maximum light yield recorded at 600 K. Our results show that LaBr 3 :5% Ce 3+ and LaCl 3 :10% Ce 3+ crystals can be used in applications where temperature conditions are extreme such as in oil well logging. (© 2006 WILEY‐VCH Verlag GmbH &amp; Co. KGaA, Weinheim)
Effects of nanostructure geometry on polymer chain alignment and device performance in nanoimprinted polymer solar cell (2013)

Among the various organic photovoltaic devices, the conjugated polymer/fullerene approach has drawn the most research interest. The performance of these types of solar cells is greatly determined by the nanoscale morphology of the two components (donor/acceptor) and the molecular orientation/crystallinity in the photoactive layer. This article demonstrates our recent studies on the nanostructure geometry effects on the nanoimprint induced poly(3 hexylthiophene-2,5-diyl) (P3HT) chain alignment and photovoltaic performance. Out-of-plane and in-plane grazing incident X-ray diffractions are employed to characterize the chain orientations in P3HT nanogratings with different <i>widths</i> and <i>heights</i>. It is found that nanoimprint procedure changes the initial edge-on alignment in non-imprinted P3HT thin film to a vertical orientation which favors the hole transport, with an organization <i>height H</i>≥ 170 nm and <i>width</i> in the range of 60 nm&le; W&lt; 210 nm. Samples with better aligned molecules lead to a larger crystallite sizes as well. Imprinted P3HT/[6,6]-penyl-C61-butyric-acid-methyl-ester (PCBM) solar cells show an increase in power conversion efficiency (PCE) with the decrease of nanostructure width, and with the increase of height and junction area. Devices with the highest PCE are made by the fully aligned and highest P3HT nanostructures (<i>width w</i>= 60 nm, <i>height h</i>= 170 nm), allowing for the most efficient charge separation, transport and light absorption. We believe this work will contribute to the optimal geometry design of nanoimprinted polymer solar cells.
Factors Influencing Early Admission in a French Stroke Unit (2002)

The present study shows that hospital arrival within the first hours of stroke is feasible in a French stroke unit. As many as 75% of the patients are admitted within the first 6 hours of stroke. This is the first study demonstrating that stroke unit admission in France is fastest in patients brought to the hospital by EMS or FD ambulances. However, only 35% of stroke patients activate the emergency telephone system and are currently transported by EMS or FD ambulances. French stroke patients should be encouraged to seek immediate medical attention by using the emergency telephone system, and stroke management should be reprioritized in the French EMS as a time-dependent medical emergency, with the same level of organization and expertise currently applied to myocardial infarction.
Surface CO<sub>2</sub> leakage during two shallow subsurface CO<sub>2</sub> releases (2007)

A new field facility was used to study CO 2 migration processes and test techniques to detect and quantify potential CO 2 leakage from geologic storage sites. For 10 days starting 9 July 2007, and for seven days starting 3 August 2007, 0.1 and 0.3 t CO 2 d −1 , respectively, were released from a ∼100‐m long, sub‐water table (∼2.5‐m depth) horizontal well. The spatio‐temporal evolution of leakage was mapped through repeated grid measurements of soil CO 2 flux (F CO2 ). The surface leakage onset, approach to steady state, and post‐release decline matched model predictions closely. Modeling suggested that minimal CO 2 was taken up by groundwater through dissolution, and CO 2 spread out on top of the water table. F CO2 spatial patterns were related to well design and soil physical properties. Estimates of total CO 2 discharge along with soil respiration and leakage discharge highlight the influence of background CO 2 flux variations on detection of CO 2 leakage signals.
Clinicopathological associations of hemispheric dominance in primary progressive apraxia of speech (2023)

Patients with PPAOS and a right-dominant pattern of hypometabolism on FDG-PET have the fastest rates of decline of behavioral and motor features.
On-chip size, low-noise fringe pattern projector offering highly accurate 3D measurement (2023)

Fringe pattern projectors are quite useful for highly accurate three-dimensional (3D) measurement when a projector or LED array is used for illumination. We have fabricated a 0.2 mm × 0.2 mm structured light source, which was an on-chip size surface-emitting laser that utilized a holographically modulated two-dimensional (2D) photonic crystal (PC). This will make possible an extremely compact 3D measurement system that will positively impact mobile systems. However, the fringe pattern tends to cause speckle-like noise that leads to severe positional error in 3D measurement. Here we present a simple approach to projecting a low-noise fringe pattern from our surface-emitting lasers by using a one-dimensional (1D) focusing hologram. This method improves the flatness of the fringe pattern by around four times.
Photorefractive properties of undoped, Cr-doped, and Cu-doped potassium sodium strontium barium niobate crystals (1993)

We determine several photorefractive properties of undoped, Cr-doped, and Cu-doped (KyNa1–y)2z, (SrxBa1–x)1–z Nb2O6 (KNSBN) crystals by means of two-beam coupling measurements. An elemental analysis of the crystals to determine their compositions and impurities is also performed. It is found that two-beam coupling gain of the Cr-doped KNSBN at 514.5 nm is enhanced by ~10 times that of the undoped KNSBN, while its response speed remains substantially unchanged. Longer-wavelength photorefractivity is also observed in the Cr-doped KNSBN. Quasi-periodic oscillations of the probe-beam intensity in the two-beam coupling experiment are observed in the Cu-doped KNSBN.
A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery (2015)

Upper-limb RIPC performed while patients were under propofol-induced anesthesia did not show a relevant benefit among patients undergoing elective cardiac surgery. (Funded by the German Research Foundation; RIPHeart ClinicalTrials.gov number, NCT01067703.).