gebhart/patrepeval huggingface dataset:
Inhibition of rat liver fibrogenesis through noradrenergic antagonism (2002)

The effect of adrenergic innervation and/or circulating catecholamines on the function of liver fibrogenic cells is poorly understood. Our aim was to investigate the effects of noradrenergic antagonism on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. Two weeks of CCl4 induced an approximately 5-fold increase in the area of fibrosis as compared with controls. The addition of 6-hydroxydopamine (OHDA), a toxin that destroys noradrenergic fibers, decreased fibrosis by 60%. After 6 weeks of CCl4, the area of fibrosis increased about 30-fold in CCl4-treated animals and was decreased by 36% with OHDA. At 2 weeks, OHDA abrogated the CCl4-induced increase in mRNA level of tissue inhibitor of matrix metalloproteinases-1 (TIMP-1), an inhibitor of extracellular matrix degradation, and it greatly reduced it at 6 weeks. Finally, when rats treated with CCl4 for 2 weeks also received prazosin, an antagonist of alpha1-adrenergic receptors, fibrosis was decreased by 83%. In conclusion, destruction of noradrenergic fibers or antagonism of noradrenergic signaling through alpha1 receptors inhibited the development of liver fibrosis. Because adrenoreceptor antagonists have a very sound safety profile, they appear as attractive drugs to reduce liver fibrogenesis.
Application of co-culture technology of epithelial type cells and mesenchymal type cells using nanopatterned structures (2020)

Various nanopatterning techniques have been developed to improve cell proliferation and differentiation efficiency. As we previously reported, nanopillars and pores are able to sustain human pluripotent stem cells and differentiate pancreatic cells. From this, the nanoscale patterns would be effective environment for the co-culturing of epithelial and mesenchymal cell types. Interestingly, the nanopatterning selectively reduced the proliferative rate of mesenchymal cells while increasing the expression of adhesion protein in epithelial type cells. Additionally, co-cultured cells on the nanopatterning were not negatively affected in terms of cell function metabolic ability or cell survival. This is in contrast to conventional co-culturing methods such as ultraviolet or chemical treatments. The nanopatterning appears to be an effective environment for mesenchymal co-cultures with typically low proliferative rates cells such as astrocytes, neurons, melanocytes, and fibroblasts without using potentially damaging treatments.
Dynamic Geotechnical Testing II (1994)

Description Cyclic and dynamic testing of soils for geotechnical engineering purposes and centrifuge testing has emerged as a new tool for understanding soil behavior and dynamic soil-structure interaction. STP 1213 is an excellent reference document on these latest testing practices, and emerging technologies and provides additional information on measuring soil properties used cyclic and dynamic loading conditions. 25 peer-reviewed papers give you an understanding of field, laboratory, and centrifuge methods used in cyclic and dynamic testing of soils for geotechnical engineering purposes. The papers discuss: • Descriptions of facilities, apparatus, and instrumentation used • Theoretical analysis of apparatus and/or instrumentation • Results and analysis of experimental research • Discussion of testing procedures, improvements, and guidelines
Adhesion Mechanisms of Polyurethanes to Glass Surfaces. III. Investigation of Possible Physico-Chemical Interactions at the Interphase (1996)

Abstract Surface free energies of polyurethanes made from toluene diisocyanate and 1, 4 butanediol-based hard segments and caprolactone polyol-based soft segments were calculated using additive functions. Good agreement was found between the calculated values based on additive functions and the calculated values based on contact angle measurements. The phase-separated polyurethanes were found to have a higher polar surface free energy component (γP). This was linked to the preferential segregation of butanediol/butanediol-derived moieties to the polyurethane surfaces due to phase separation. The adhesion values of these polyurethanes to soda-lime glass were correlated with their respective γP values and a linear relationship was found. It was also shown that the adhesion values of the low γP polyurethanes improved substantially when the glass surfaces were coated with a thin layer of butanediol prior to the bonding. The modulus of the interphase region rich in butanediol was evaluated. Although a modulus increase was found at the interface, this increase was found to play a secondary role in the adhesion. The chemical interactions at the polyurethane/glass interphase were investigated by pre-treating the glass surfaces with methyl-trimethoxysilane and trimethylchlorosilane prior to adhesion testing. The adhesion data showed no significant difference between the uncoated and the silane-treated glass substrates. Based on this experimental evidence, the possibility of any covalent or ionic bonding at the polyurethane/glass interphase was assumed negligible. It was determined that the mechanism of adhesion between the polyurethanes and the glass surface could be through the formation of an interphase region in which hydrogen bonding between the butanediol-rich interphase region and the hydroxylated glass surface plays a key role.
An Investigation into Causes and Effects of High Cyanide Levels in the Palladium-Catalyzed Cyanation Reaction (2004)

[reaction: see text] The palladium-catalyzed cyanation reaction is known to be sensitive to dissolved cyanide. Investigation into some causes of high levels of dissolved cyanide is presented here, along with a robust solution to this problem.
Supplementary material from "Secondary metabolite arsenal of an opportunistic pathogenic fungus" (2016)

<i>Aspergillus fumigatus</i> is a versatile fungus able to successfully exploit diverse environments from mammalian lungs to agricultural waste products. Among its many fitness attributes are dozens of genetic loci containing biosynthetic gene clusters (BGCs) producing bioactive small molecules (often referred to as secondary metabolites or natural products) that provide growth advantages to the fungus dependent on environment. Here we summarize the current knowledge of these BGCs—18 of which can be named to product<i>—</i>their expression profiles <i>in vivo</i> and which BGCs may enhance virulence of this opportunistic human pathogen. Furthermore, we find extensive evidence for the presence of many of these BGCs, or similar BGCs, in distantly related genera including the emerging pathogen <i>Pseudogymnoascus destructans</i>, the causative agent of white-nose syndrome in bats, and suggest such BGCs may be predictive of pathogenic potential in other fungi.This article is part of the themed issue ‘Tackling emerging fungal threats to animal health, food security and ecosystem resilience’.
Supplementary Material from Selective Estrogen Receptor Modulators and Pharmacogenomic Variation in ZNF423 Regulation of BRCA1 Expression: Individualized Breast Cancer Prevention (2023)

&lt;p&gt;Supplementary Material - PDF file 131K, Provision of Supplementary material relating to methods, tables for patient characteristics, SNP-covariate interactions, SNP effects on time to breast cancer, top SNPs on chromosomes 4 and 16, and supplementary Figure legends&lt;/p&gt;
Exergy destruction in ammonia scrubbers (2018)

A theoretical ammonia scrubbing process by sulfuric acid solution is assessed with the concept of exergy. The exergy destruction of chemical neutralization is mainly (75–94%) due to changes in the chemical exergy of streams and thermal effects from the reaction while mixing effects have a limited contribution (6–25%). The minimum exergy consumption to remove one mole of ammonia chemically from an airstream could be two to eight times larger than the latent heat of evaporation of one mole of water depending on whether a concentrated (98% w/w) or a dilute (1% w/w) sulfuric acid solution is used. The exergy destruction per mole of ammonia scrubbed could be reduced by up to 75% when both the sulfuric acid solution and the ammonia at the inlet airstream are highly concentrated. The use of sulfuric acid concentration in the range of 10–50% w/w could lead to a very low exergy efficiency (<50%). The exergy efficiency could be improved up to ∼87% by introducing an ammonia pre-concentration step right before the scrubbing process. The extension of system boundaries shows that the cumulative exergy loss rate for neutralizing a heavily loaded ammonia airstream with a flowrate of 1 kg s−1 ranges between 0.3–1.5 MW depending on the way sulfuric acid is produced. Consequently, an exergy-efficient scrubber design should balance between the minimization of the consumption of exergy-intensive resources, the minimization of the exergy destruction occurring in the separation process, and the maximization of output stream utilization.
Combining Free Flap Reconstruction and Craniofacial Prosthetic Technique for Orbit, Scalp, and Temporal Defects (1998)

Craniofacial prosthetic techniques can significantly augment the results of free flap surgery for the orbit, scalp, and temporal region. Successful combination of these techniques requires a site-specific surgical approach.
Customized impedance spectroscopy device as possible sensor platform for biosensor applications (2010)

Abstract A new impedance spectroscopy unit is developed, fully customized to become a vital part of label free biosensor arrays with possible applications in DNA and protein sensing. Test measurements are conducted to explore the accuracy and specificity of the system, both under electronic lab conditions as well as under wet cell conditions with synthetic‐diamond based sensor electrodes. The impedance of seven resistors was monitored for 17 h and a maximum error &lt;0.02% was found. Furthermore, the impedance of PBS at different concentrations was monitored for 60 min per concentration and a different impedance for each concentration was detected. The impedance is also monitored for NaOH, PBS and nuclease free water at different temperatures with a total duration of 60 min per fluid. Systematically different impedances for each temperature per fluid were found and the temperature coefficients were determined. All test measurements lead to results well within specification.
Expert Consensus Document on the Use of Antiplatelet Agents The Task Force on the Use of Antiplatelet Agents in Patients with Atherosclerotic Cardiovascular Disease of the European Society of Cardiology (2003)

\n Contains fulltext :\n 58492.pdf (Publisher’s version ) (Closed access)\n
A mathematical model for the optimal design and operation of an anaerobic co-digestion plant (1996)

The anaerobic co-digestion of high strength industrial wastewaters in centralised plants receiving effluents from various local small scale industries is considered to be superior than individual small scale treatment plants. An approach is proposed to systematically tackle co-digestion problems, with respect to both biological and engineering models. In a steady-state mathematical model presented, the effect of combining wastewaters in mixtures, based on major component groups (i.e. lipids, hydrocarbons and proteins), is systematically accounted for. The model is then solved via a non-linear optimisation program (NLP) which results in the determination of an optimal design of the necessary reactors and their respective layout, by balancing the natural trade-offs between reactor and post-treatment costs (due to high pollutants emissions). The preparation of appropriate mixtures is the major parameter controlled. The applicability and potential of the model are demonstrated with a small example.
Procarbazine and CCNU as Initial Treatment in Gliomatosis Cerebri (2008)

These data support the efficacy of PC chemotherapy in newly diagnosed GC. Initial PC chemotherapy should be considered as a treatment option and evaluated in larger clinical trials.
Benchmark for Algorithms Segmenting the Left Atrium From 3D CT and MRI Datasets (2015)

Knowledge of left atrial (LA) anatomy is important for atrial fibrillation ablation guidance, fibrosis quantification and biophysical modelling. Segmentation of the LA from Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) images is a complex problem. This manuscript presents a benchmark to evaluate algorithms that address LA segmentation. The datasets, ground truth and evaluation code have been made publicly available through the http://www.cardiacatlas.org website. This manuscript also reports the results of the Left Atrial Segmentation Challenge (LASC) carried out at the STACOM'13 workshop, in conjunction with MICCAI'13. Thirty CT and 30 MRI datasets were provided to participants for segmentation. Each participant segmented the LA including a short part of the LA appendage trunk and proximal sections of the pulmonary veins (PVs). We present results for nine algorithms for CT and eight algorithms for MRI. Results showed that methodologies combining statistical models with region growing approaches were the most appropriate to handle the proposed task. The ground truth and automatic segmentations were standardised to reduce the influence of inconsistently defined regions (e.g., mitral plane, PVs end points, LA appendage). This standardisation framework, which is a contribution of this work, can be used to label and further analyse anatomical regions of the LA. By performing the standardisation directly on the left atrial surface, we can process multiple input data, including meshes exported from different electroanatomical mapping systems.
Barium Hydroxide as an Interlayer Between Zinc Oxide and a Luminescent Conjugated Polymer for Light‐Emitting Diodes (2012)

Abstract A study of hybrid light‐emitting diodes (HyLEDs) fabricated with and without solution‐processible Cs 2 CO 3 and Ba(OH) 2 inorganic interlayers is presented. The interlayers are deposited between a zinc oxide electron‐injection layer and a fluorescent emissive polymer poly(9‐dioctyl fluorine–alt‐benzothiadiazole) (F8BT) layer, with a thermally evaporated MoO 3 /Au layer used as top anode contact. In comparison to Cs 2 CO 3 , the Ba(OH) 2 interlayer shows improved charge carrier balance in bipolar devices and reduced exciton quenching in photoluminance studies at the ZnO/Ba(OH) 2 /F8BT interface compared to the Cs 2 CO 3 interlayer. A luminance efficiency of ≈28 cd A −1 (external quantum efficiency (EQE) ≈ 9%) is achieved for ≈1.2 μm thick single F8BT layer based HyLEDs. Enhanced out‐coupling with the aid of a hemispherical lens allows further efficiency improvement by a factor of 1.7, increasing the luminance efficiency to ≈47cd A −1 , corresponding to an EQE of 15%. The photovoltaic response of these structures is also studied to gain an insight into the effects of interfacial properties on the photoinduced charge generation and back‐recombination, which reveal that Ba(OH) 2 acts as better hole blocking layer than the Cs 2 CO 3 interlayer.
Superhigh-power picosecond optical pulses from Q-switched diode laser (1997)

Generation of 40-ps optical pulses was demonstrated with a peak power of up to 45 W in a single mode and of up to 380 W from a broad-area laser diode. Such optical power was achieved in the Q-switching regime by means of a saturable absorber formed inside the laser cavity by deep implantation of heavy ions.
P0072 / #1748: FACTORS INFLUENCING DELIRIUM SCREENING IN PEDIATRIC INTENSIVE CARE PATIENTS (2021)

Aims & Objectives: The objective of this study is to determine patient-level factors associated with performance of delirium screening in PICUs with established delirium screening protocols. Methods: Data was obtained from the PICU Up! pilot trial, a multicenter stepped-wedge trial examining the effect of a multicomponent early mobility intervention in critically ill pediatric patients. All PICU patients admitted ≥3 days during the pre-intervention period (n=1160) in 6 PICUs with delirium screening protocols were included in the analysis. A multivariable logistic regression was performed to determine factors associated with delirium screening. Results: Out of 1160 patients, 68% were screened for delirium at least once during PICU admission. Patients screened for delirium had longer median lengths of stay than those never screened for delirium (8 days (IQR 5-13) vs. 5 days (IQR 3.5-8); p<0.001). Mechanical ventilation on the day of admission was associated with an increase in screening for delirium (OR 2.27; 95%CI 1.02-5.03, p=0.044). Moderate disability, as demonstrated by the Pediatric Overall Performance Category Score, was associated with increased odds of screening (OR 4.22; 95%CI 1.37-13.0, p=0.01) compared to normal baseline function. Usage of opioids (p=0.50) and benzodiazepines (p=0.07) was not associated with odds of delirium screening. Conclusions: Despite a high prevalence of delirium, delirium screening is not universal in the PICU, even in the presence of established unit screening protocols. Mechanically ventilated patients and those with baseline functional impairment are more likely to receive screenings. These findings highlight the importance of delirium education and widespread screening to ensure delirium prevention and management are optimized for all critically ill children.
Ion channels in autoimmune neurodegeneration (2011)

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system characterized by widespread inflammation, focal demyelination and a variable degree of axonal and neuronal loss. Ionic conductances regulate T cell activation as well as neuronal function and thus have been found to play a crucial role in MS pathogenesis. Since present therapeutical approaches are only partially effective so far, ion channel modulation as a future strategy was brought into focus. Here, we review the status quo concerning recent findings from ion channel research in MS and its animal model, experimental autoimmune encephalomyelitis.
Use of Dietary Supplements among Professional Athletes in Saudi Arabia (2013)

The objective of this study was to understand the usage patterns of dietary supplements among professional athletes in Saudi Arabia. The survey consisted of sixteen questions divided into four categories: use of supplements, reason for consumption of supplements, personal beliefs about supplements, and behavior. The questionnaires were given to the three teams residing in Riyadh: Al Hilal, Al Nasr, and Al-Shabab. Out of the 105 athletes surveyed, we found that only 98 are currently taking dietary supplements and the mean age and standard deviation were 25.74 ± 2.90. The survey results showed a high percentage of athletes (93.3%; n = 98) using different dietary supplements throughout the season, 43.8% (n = 43) reported using supplements for performance, and 32.6% (n = 32) believed in health benefits as a reason for using dietary supplements. Our results showed that a total of 87 (88.7%), 81 (82.6%), and 51 (52.0%) athletes are consuming sports drinks, vitamin C, and multivitamins, respectively. Meanwhile, those supplements ranking among the least used included omega 6 (18.6%), creatine (16.3%), and Ginkgo biloba (10.2%). A majority of athletes indicated that their use of supplements was for the purpose of improving their health and performance.
pcApriori (2013)

Frequent-itemset mining is an important part of data mining. It is a computational and memory intensive task and has a large number of scientific and statistical application areas. In many of them, the datasets can easily grow up to tens or even several hundred gigabytes of data. Hence, efficient algorithms are required to process such amounts of data. In the recent years, there have been proposed many efficient sequential mining algorithms, which however cannot exploit current and future systems providing large degrees of parallelism. Contrary, the number of parallel frequent-itemset mining algorithms is rather small and most of them do not scale well as the number of threads is largely increased. In this paper, we present a highly-scalable mining algorithm that is based on the well-known Apriori algorithm; it is optimized for processing very large datasets on multiprocessor systems. The key idea of pcApriori is to employ a modified producer--consumer processing scheme, which partitions the data during processing and distributes it to the available threads. We conduct many experiments on large datasets. pcApriori scales almost linear on our test system comprising 32 cores.
A Regularized System Identification Approach to Subject-Specific Physiological Modeling with Limited Data (2019)

This paper investigates a novel regularized system identification approach to physiological modeling using limited data. The proposed approach operates in two steps: 1) limited data from individual subjects are consolidated and leveraged to determine a population-average physiological model; then, 2) a subject-specific model for an individual subject is derived from a regularized system identification procedure whose objective is to reconcile the model's capability to predict individual-specific behavior and to retain typical population-representative trends. This is achieved by embedding a regularizing condition into the cost function for system identification that enforces parsimony in parametric deviation from the population-average model. A few unique advantages of the proposed approach are that 1) it offers superior predictive accuracy in both measured as well as unmeasured physiological system responses when compared to a standard system identification approach; and 2) it provides high-sensitivity parameters in the model associated with each individual subject, thus potentially eliminating the necessity for post-hoc parametric sensitivity analysis. Merits and limitations of the proposed regularized approach are illustrated with a real world case study on physiological modeling of hemodynamics in response to burn injury and resuscitation.
Where to find practical patient education materials (1999)

(1999). Where to find practical patient education materials. Postgraduate Medicine: Vol. 106, No. 6, pp. 35-38.
Rheology of bidisperse aqueous silica suspensions: A new scaling method for the bidisperse viscosity (1998)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation A. A. Zaman, B. M. Moudgil; Rheology of bidisperse aqueous silica suspensions: A new scaling method for the bidisperse viscosity. J. Rheol. 1 January 1998; 42 (1): 21–39. https://doi.org/10.1122/1.550935 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search