338 PROSTATE CANCER IN THE ELDERLY FREQUENCY OF ADVANCED DISEASE AT PRESENTATION AND DISEASE-SPECIFIC MORTALITY (2012)

You have accessJournal of UrologyProstate Cancer: Epidemiology and Natural History II1 Apr 2012338 PROSTATE CANCER IN THE ELDERLY FREQUENCY OF ADVANCED DISEASE AT PRESENTATION AND DISEASE-SPECIFIC MORTALITY Emil Scosyrev, Edward Messing, Supriya Mohile, Dragan Golijanin, and Guan Wu Emil ScosyrevEmil Scosyrev Rochester, NY More articles by this author , Edward MessingEdward Messing Rochester, NY More articles by this author , Supriya MohileSupriya Mohile Rochester, NY More articles by this author , Dragan GolijaninDragan Golijanin Rochester, NY More articles by this author , and Guan WuGuan Wu Rochester, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.399AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES The objectives of this study were to determine the frequency of metastatic (M1) PC at presentation in different age groups, to examine the association of age with PC-specific mortality, and to calculate the relative contribution of different age groups to the pool of presenting M1 PC cases and PC deaths. METHODS Records of 464,918 patients diagnosed with PC during 1998-2007 were obtained from the Surveillance, Epidemiology, and End Results database. Advanced PC was defined as M1 disease. Age was grouped as: <50, 50-54, 55-59, 60-64, 65-69, 70-74, 75-79, 80-84, 85-89, 90+. The cumulative incidence of death from PC was computed using Gray's method. RESULTS The frequency of M1 PC at presentation was 3% for the group aged <75 years, 5% for the group ages 75 to 79 years, 8% for the group ages 80 to 84 years, 13% for the group ages 85 to 89 years, and 17% for the group aged 90+ years. The 5-year cumulative incidence of death from PC was 3% to 4% for all patients with PC in any category aged <75 years, 7% for patients ages 75 to 79 years, 13% for patients ages 80 to 84 years, 20% for patients ages 85 to 89 years, and 30% for patients aged 90+ years. Despite representing 16% of older (50+ year old) male adults in the general population and 26% of all PC diagnoses, men age 75 and older contributed almost half (48%) of all presenting M1 PC cases and more than half (53%) of all PC deaths. CONCLUSIONS Compared with younger men (<75 years old), older men were more likely to present with very advanced PC, had a greater risk of death from PC despite higher death rates from competing causes, and made a disproportionately large contribution to the total numbers of presenting M1 PC cases and PC deaths. Awareness of these issues may improve future outcomes for elderly patients with PC. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e137-e138 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Emil Scosyrev Rochester, NY More articles by this author Edward Messing Rochester, NY More articles by this author Supriya Mohile Rochester, NY More articles by this author Dragan Golijanin Rochester, NY More articles by this author Guan Wu Rochester, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...