gebhart/patrepeval huggingface dataset:
Enhanced Hairpin Stability through Loop Design:  The Case of the Protein G B1 Domain Hairpin (2004)

A mutational study of the peptide corresponding to the second hairpin of the protein G B1 domain (GB1p) provided a series of mutants with significantly increased fold stability. Mutations focused on improvement of the direction-reversing loop and the addition of favorable Coulombic interactions at the sequence termini. The loop optimization was based on a database search for residues that occur with the greatest probability in similar hairpin loops in proteins. This search suggested replacing the native DDATKT sequence with NPATGK, which resulted in a 4.5 kJ/mol stabilization of the hairpin fold. The introduction of positively charged lysines at the N-terminus provided an additional 2.4 kJ/mol of stabilization, affording a GB1p mutant that is 86 +/- 3% folded at 25 degrees C with a melting temperature of 60 +/- 2 degrees C. The trpzip version of this peptide, in which three of the hydrophobic core residues were mutated to tryptophan, yielded a sequence that melted at 85 degrees C. Throughout, fold populations and melting temperatures were derived from the mutation and temperature dependence of proton chemical shifts and were corroborated by circular dichroism (CD) melts. The study also suggests that the wild-type GB1p sequence is significantly less stable than reported in some other studies: only 30% folded in water at 25 degrees C.
Automatic Tv Logo Removal Using Statistical Based Logo Detection And Frequency Selective Inpainting (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
Concepts and controversies of juvenile myoclonic epilepsy: still an enigmatic (2014)

Juvenile myoclonic epilepsy (JME) is a clinically and genetically heterogenous, generalized epilepsy syndrome usually starting in adolescence. An age-related, predominantly frontocortical-subcortical network dysfunction is likely to be the substrate of bilateral myoclonic seizures occurring at full consciousness within hours after awakening, which are the clinical hallmark of JME. Although essential features of JME were recognized by Herpin more than 140 years ago, it is still an enigmatic epilepsy syndrome in many ways; advanced imaging techniques reveal multi-focal abnormalities in this paradigmatic generalized epilepsy syndrome; clinical studies reveal a major role of genetics in etiology, but the underlying molecular changes are likely to be highly heterogeneous; many JME patients have psycho-social issues, even though their intelligence is normal; antiepileptic drugs (AEDs), notably valproic acid, achieve seizure remission in two thirds of patients, but more patients seem to relapse after stopping AEDs than in any other epilepsy syndrome. This pessimistic outlook has been challenged in recent population-based studies and needs to be assessed in randomized AED withdrawal trials. This review summarizes recent focus neuroimaging, genetic, and behavioral aspects of JME and re-appraises the entrenched view that remission off AEDs is exceptionally rare in JME.
DNA promotes the reaction of cis-diamminedichloroplatinum(II) with the exocyclic amino groups of ethidium bromide (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDNA promotes the reaction of cis-diamminedichloroplatinum(II) with the exocyclic amino groups of ethidium bromideWesley I. Sundquist, Daniel P. Bancroft, Laurent. Chassot, and Stephen J. LippardCite this: J. Am. Chem. Soc. 1988, 110, 25, 8559–8560Publication Date (Print):December 1, 1988Publication History Published online1 May 2002Published inissue 1 December 1988https://pubs.acs.org/doi/10.1021/ja00233a050https://doi.org/10.1021/ja00233a050research-articleACS PublicationsRequest reuse permissionsArticle Views211Altmetric-Citations38LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
<i>Ruminococcus gnavus</i>E1 modulates mucin expression and intestinal glycosylation (2016)

Furthermore, we demonstrated that R. gnavus E1 modified specifically the glycosylation pattern and MUC2 expression by means of a small soluble factor of peptidic nature (<3 kDa) and heat stable in the HT29-MTX cell.
Flow Cytometry First Principles (1994)

Journal Article Flow Cytometry First Principles Get access Longobardi Givan Alice. Flow Cytometry First Principles. New York: Wiley-Liss, 1992, 202 pp. $38.95. Charles L. Hitchcock, MD, PhD Charles L. Hitchcock, MD, PhD Department of Pathology The Ohio State University Columbus, Ohio Search for other works by this author on: Oxford Academic Google Scholar American Journal of Clinical Pathology, Volume 102, Issue 5, 1 November 1994, Page 703, https://doi.org/10.1093/ajcp/102.5.703 Published: 01 November 1994
Instantaneous Center of Rotation in Pitch Response of a FPSO Submitted to Head Waves (2018)

When under influence of an incident wave system, any floating body presents a general motion with all six degrees of freedom, unless it presents some kind of restrains on it. For a free moving body, the center of rotation will depend on the force distribution and might not coincide with its center of gravity. For long and slender floating structures, such as FPSO platforms, a small change in the center of Pitch rotation would result in significant change in the overall motions in its fore and aft regions. Therefore, it is of high importance to obtain a better understating of the instantaneous position of the body center of rotation in Heave and Pitch response. This paper investigates the position of the Instantaneous Center of Rotation in Pitch Response of a scaled down model of a FPSO platform under different regular wave conditions. The investigation uses basic kinematics equations for rigid body, defining the 6 degrees of freedom of the rigid body motion from a finite number of markers installed in the model. A high quality tracking system captures the markers positions in order to define the rigid body at each instant of time. For an initial approach, the study considers the response due to head waves seas with experimental validation.
Influence of Polymer Properties on Potential Induced Degradation of PV-Modules (2013)

Solar Cells that are prone to Potential Induced Degradation (PID) have been laminated as one-cell mini modules with various types of back sheet and encapsulation materials. Additionally, water soaking and water permeation properties of the encapsulation and back sheet materials have been tested. It was found that modules containing materials with low barrier and high soaking properties lead to a strong loss in shunt resistance after a short period of time. At the same time, materials with high barrier and low soaking properties protect the cells against electrical degradation under high voltage potentials. Surprisingly, modules containing the TPO-encapsulant showed an increase of shunt resistance during during PID test.
Remapping Control in VR for Patients with AMD (2023)

Age-related Macular Degeneration (AMD) is the leading cause of vision loss among persons over 50. We present a two-part interface consisting of a VR-based visualization for AMD patients and an interconnected doctor interface to optimize this VR view. It focuses on remapping imagery to provide customized image optimizations. The system allows doctors to generate a tailored, patient-specific VR visualization. We pilot tested the doctor interface (n=10) with eye care professionals. The results indicate the potential of VR-based eye care for doctors to help visually-impaired patients, but also show a necessary training phase to establish new technologies in vision rehabilitation.
Estimating the Dosage of Ribavirin Aerosol According to Age and Other Variables (1988)

We describe a method for estimating the dosage of aerosolized ribavirin according to age. The calculations were determined by using a computer model of particle deposition, and corrections are described for sex, body weight, fever, and tracheal intubation. Respiratory tract deposition in infants, after they inhaled an aerosol containing 200 micrograms of ribavirin/L, was 1.8 mg/kg per hour; in adults the deposition was 0.9 mg/kg per hour. Adolescent females and older women have less (7%/kg) respiratory tract deposition than do males. Fever will increase deposition about 9%/degree Centigrade (5%/degree Fahrenheit) for each degree of increase above normal temperature. Tracheal intubation will deliver relatively more drug to the lung and no drug to the nasopharynx. Our report shows the regional and total deposition of inhaled ribavirin aerosol in the respiratory tracts of persons in different age-groups from three months to 25 y.
Nanoscale Shape-Memory Function in Highly Cross-Linked Polymers (2008)

Topographic engraving of structures in polymer surfaces attracts widespread interest for application in imprint lithography and data storage. We study the nonlinear interaction of nanoindents written in close proximity, 20-100 nm, to one another in a highly cross-linked polystyrene matrix. The indents are created thermomechanically by applying heat and force stimuli of 10 micros duration to a tip, thereby raising the polymer temperature to 250 degrees C and exerting contact pressures of up to 1 GPa. We show that on the nanoscale plastic deformation is highly reversible providing outstanding shape-memory functionality of the material.
ChemInform Abstract: GEMINAL INTERACTIONS AT THE TERMINI OF POLYENES (1977)

Abstract Durch eine Fülle von Berechnungen nach der "Frontier"‐M0‐Methode an z.B. Methylen, Äthylen, Cyclopropan, Butadien, Hexatrien, Allyl‐, Pentadienyl‐, Heptat?enyl‐Anion und ‐Kation wird die geminale Wechselwirkung inter‐ und intramolekularer Art untersucht.
Signal-to-noise criterion for free-propagation imaging techniques at free-electron lasers and synchrotrons (2016)

We propose a signal-to-noise criterion which predicts whether a feature of a given size and scattering strength, placed inside a larger object, can be retrieved with two common X-ray imaging techniques: coherent diffraction imaging and projection microscopy. This criterion, based on how efficiently these techniques detect the scattered photons and validated through simulations, shows in general that projection microscopy can resolve smaller phase differences and features than coherent diffraction imaging. Our criterion can be used to design optimized imaging experiments and perform feasibility studies for sensitive biological materials in free-electron lasers, where the number of photons per pulse is limited, or in synchrotron experiments, for both techniques.
A fluid connection: Cholesterol and Aβ (2001)

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social sciences.
Article citation study: Context enhanced citation sentiment detection (2020)

Citation sentimet analysis is one of the little studied tasks for scientometric analysis. For citation analysis, we developed eight datasets comprising citation sentences, which are manually annotated by us into three sentiment polarities viz. positive, negative, and neutral. Among eight datasets, three were developed by considering the whole context of citations. Furthermore, we proposed an ensembled feature engineering method comprising word embeddings obtained for texts, parts-of-speech tags, and dependency relationships together. Ensembled features were considered as input to deep learning based approaches for citation sentiment classification, which is in turn compared with Bag-of-Words approach. Experimental results demonstrate that deep learning is useful for higher number of samples, whereas support vector machine is the winner for smaller number of samples. Moreover, context-based samples are proved to be more effective than context-less samples for citation sentiment analysis.
Development of a Membrane-on-Catalyst Hydrogen Production Module for Steam Reforming of City Gas (2017)

天然ガスからの水蒸気改質器にPd系水素分離膜を組み込んだメンブレンリアクターの概念を適用した水素分離型リフォーマー（MRF: Membrane reformer）は，一つの反応器で改質反応と水素分離を同時に行い，化学平衡の制約を逃れた反応促進が可能なため，シンプル，コンパクト，高効率な水素製造技術として期待される．我々は，水素分離型リフォーマーのさらなるシンプル化，コンパクト化を目的として，触媒機能を付与した支持体とPd合金製水素分離膜が一体となった新しいコンセプトの水素分離膜モジュールである触媒一体化膜モジュール（MOC: Membrane on Catalyst）を開発し，都市ガスの水蒸気改質による水素製造性能の評価を行った．
Population genetic structure of the people of Qatar (2010)

People of the Qatari peninsula represent a relatively recent founding by a small number of families from three tribes of the Saudi peninsula, Persia, and Oman, with some African admixture. To assess the combination of this founding effect and first-cousin marriages on Qatar&apos;s population genetic structure, in a collaborative program of Weill Cornell-Qatar and Weill Cornell-New York, Cornell University and Qatar University, we assessed DNA samples from self-reported Qatari nationals using Affymetrix SNP Array 5.0 to obtain genotype calls of nearly 500,000 single nucleotide polymorphisms (SNPs) in each individual. Principal component analysis was performed along with samples from the Human Genetic Diversity Project dataset, revealing three clusters of genotypes whose proximity to other human population samples is consistent with Arabian origin, a more eastern/Persian origin, and African admixture. The extent of linkage disequilibrium is greater than that of African populations, and runs of homozygosity reflect substantial consanguinity. Despite the fact that the SNPs have a bias toward SNPs common in Europeans, the data strongly support the notion that the Qatari population will provide a valuable resource for the mapping of genes associated with complex disorders. This approach is being tested in samples of the 3 Qatari genomic clusters of healthy vs individuals with type 2 diabetes, a disorder with a high incidence in the Qatari population. To provide a basis for these studies, we have initiated a detailed assessment of the 3 clusters of Qatari genotypes using exome capture and massive parallel sequencing. We expect that these data will provide an invaluable resource for the adaptation of “personalized medicine” for the assessment of risk and the rational use of therapies for the Qatari population.
ICA-based sparse feature recovery from fMRI datasets (2010)

Spatial Independent Components Analysis (ICA) is increasingly used in the context of functional Magnetic Resonance Imaging (fMRI) to study cognition and brain pathologies. Salient features present in some of the extracted Independent Components (ICs) can be interpreted as brain networks, but the segmentation of the corresponding regions from ICs is still ill-controlled. Here we propose a new ICA-based procedure for extraction of sparse features from fMRI datasets. Specifically, we introduce a new thresholding procedure that controls the deviation from isotropy in the ICA mixing model. Unlike current heuristics, our procedure guarantees an exact, possibly conservative, level of specificity in feature detection. We evaluate the sensitivity and specificity of the method on synthetic and fMRI data and show that it outperforms state-of-the-art approaches.
The Fabrication of Freestanding Heterogeneous Copper-Tin Films with Meniscus Brush Plating Electrodeposition (2016)

A meniscus brush plating electrodeposition technique was utilized in conjunction with a post deposition heat treatment to formulate freestanding copper-tin alloy films for negative electrodes of lithium-ion batteries. The described fabrication technique intertwined the electrode and current collector for improved cell volume utilization and stability. Two designs were examined to establish the best diffusivity to form electrochemically proficient copper-tin alloys. Fabrication was optimized to promote diffusion of copper and tin and to form the desired intermetallic phase of Cu6Sn5. This improved design fabricated films with competitive areal capacities above 1000 mAh/cc and 2.5 mAh/cm2 for the complete electrode and current collector structure.
Amplification of the aroA gene from Escherichia coli results in tolerance to the herbicide glyphosate (1983)

The predominant cellular target of the herbicide glyphosate is thought to be the enzyme 5-enolpyruvylshikimate-3-phosphoric acid synthase (EPSP synthase). As a means of biologically testing this finding, we cloned a segment of DNA from Escherichia coli that encodes this enzyme. Clones carrying the gene for EPSP synthase were identified by genetic complementation. Cells that contain a multicopy plasmid carrying the EPSP synthase gene overproduce the enzyme 5- to 17-fold and exhibit at least an 8-fold increased tolerance to glyphosate. These experiments provide direct biological evidence that EPSP synthase is a major site of glyphosate action in E. coli and that, in an amplified form, it can serve as a selectable glyphosate resistance marker.
Ultrathin nanosheets of CrSiTe<sub>3</sub>: a semiconducting two-dimensional ferromagnetic material (2015)

Two-dimensional ferromagnetic monolayer and few-layer CrSiTe<sub>3</sub>crystals are prepared for the first time from the bulk crystals by a simple mechanical exfoliation method.
Novel P,N‐Bidentate Phosphite Ligands in Asymmetric Catalysis (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Enhanced Photon Collection in Luminescent Solar Concentrators with Distributed Bragg Reflectors (2016)

Escape cone loss is one of the primary limiting factors for efficient photon collection in large-area luminescent solar concentrators (LSCs). The Stokes shift of the luminophore, however, opens up an opportunity to recycle the escaped luminescence at the LSC front surface by utilizing a photonic band-stop filter that reflects photons in the luminophore’s emission range while transmitting those in its absorption range. In this study, we examine the functional attributes of such photonic filter designs, ones realized here in the form of a distributed Bragg reflector (DBR) fabricated by spin-coating alternating layers of SiO2 and SnO2 nanoparticle suspensions onto a supportive glass substrate. The central wavelength and the width of the photonic stopband were programmatically tuned by changing the layer thickness and the refractive index contrast between the two dielectric materials. We explore the design sensitivities for a DBR with an optimized stopband frequency that can effectively act as a top angle-restricting optical element for a microcell-based LSC device, affording further capacities to boost the current output of a coupled photovoltaic cell. Detailed studies of the optical interactions between the photonic filter and the LSC using both experimental and computational approaches establish the requirements for optimum photon collection efficiencies.
A Case of Atypical Acanthamoeba Keratitis with Cruciate Stromal Infiltration (2016)

Purpose: To report a case of atypical Acanthamoeba keratitis (AK) with cruciate stromal infiltration, which was successfully treated.Case report: A 16-year-old woman with a history of intermittent soft contact lens wear was referred to our eye center. At presentation, her best-corrected visual acuity (BCVA) was 3/20 in the right eye. Slit lamp examination showed irregular epithelial infiltration, and mild edema in the cornea of the right eye. Topical antibiotics and antiviral agents were applied. After 1 week, her BCVA in the right eye decreased to counting fingers and epithelial infiltration was aggravated. Diffuse cruciate stromal infiltration newly developed. Under the presumptive diagnosis of AK, topical antibiotics and antiviral agents were stopped, and topical 0.02% chlorhexidine was started. After 2 weeks of treatment, the stromal infiltration decreased and culture was positive for Acanthamoeba species. After 3 months of treatment, the cornea was clear and her BCVA was 20/20 in the right eye.Conclusions: Atypical AK can present as cruciate stromal infiltration and can be treated successfully with topical 0.02% chlorhexidine.
Commissioning and Field Tests of a Van-Mounted System for the Detection of Radioactive Sources and Special Nuclear Material (2016)

MODES_SNM project aimed at developing a mobile/portable modular detection system for radioactive sources and Special Nuclear Material (SNM). Its main goal was to deliver a tested prototype capable of passively detecting weak or shielded radioactive sources with accuracy higher than that of currently available systems. By the end of the project all the objectives have been successfully achieved. Results from the laboratory commissioning and the field tests are presented in this publication.
Etude du rôle de la nutrition soufrée dans la réponse du pois au stress hydrique par une approche protéomique : Focus sur les graines (2017)

International audience
Time resolved studies on the photogeneration and photochemistry of tetramethyl-o-xylylene (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTime resolved studies on the photogeneration and photochemistry of tetramethyl-o-xylyleneV. Wintgens, J. C. Netto-Ferreira, H. L. Casal, and J. C. ScaianoCite this: J. Am. Chem. Soc. 1990, 112, 6, 2363–2367Publication Date (Print):March 1, 1990Publication History Published online1 May 2002Published inissue 1 March 1990https://pubs.acs.org/doi/10.1021/ja00162a041https://doi.org/10.1021/ja00162a041research-articleACS PublicationsRequest reuse permissionsArticle Views108Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts