gebhart/patrepeval huggingface dataset:
P709 LIVER HISTOLOGICAL INFLAMMATION OF CHRONIC HEPATITIS B VIRUS CARRIERS WITH PERSISTENTLY NORMAL ALANINE TRANSAMINASE (2014)

P707 CHRONIC KIDNEY DISEASE INCREASES NON-LIVER-RELATED MORTALITY IN HIV-NEGATIVE PATIENTS WITH CHRONIC HEPATITIS B INFECTION: A FRENCH NATIONWIDE HOSPITAL COHORT STUDY V. Mallet, S. Thiebaut, A. Trylesinski, M. Schwarzinger. Universite Paris Descartes, Assistance Publique – Hopitaux de Paris, Inserm, Lingha ‘Links for Global Health Assessment’, Paris Biotech Sante, THEN ‘Translational Health Economics Network’, Paris, France; Novartis Pharma AG, Basel, Switzerland E-mail: vincent.mallet@cch.aphp.fr
Nine-gene signature and nomogram for predicting survival in patients with head and neck squamous cell carcinoma (2022)

<b>Background:</b> Head and neck squamous cell carcinomas (HNSCCs) are derived from the mucosal linings of the upper aerodigestive tract, salivary glands, thyroid, oropharynx, larynx, and hypopharynx. The present study aimed to identify the novel genes and pathways underlying HNSCC. Despite the advances in HNSCC research, diagnosis, and treatment, its incidence continues to rise, and the mortality of advanced HNSCC is expected to increase by 50%. Therefore, there is an urgent need for effective biomarkers to predict HNSCC patients' prognosis and provide guidance to the personalized treatment. <b>Methods:</b> Both HNSCC clinical and gene expression data were abstracted from The Cancer Genome Atlas (TCGA) database. Intersecting analysis was adopted between the gene expression matrix of HNSCC patients from TCGA database to extract TME-related genes. Differential gene expression analysis between HNSCC tissue samples and normal tissue samples was performed by R software. Then, HNSCC patients were categorized into clusters 1 and 2 via NMF. Next, TME-related prognosis genes (<i>p</i> < 0.05) were analyzed by univariate Cox regression analysis, LASSO Cox regression analysis, and multivariate Cox regression analysis. Finally, nine genes were selected to construct a prognostic risk model and a prognostic gene signature. We also established a nomogram using relevant clinical parameters and a risk score. The Kaplan-Meier curve, survival analysis, time-dependent receiver operating characteristic (ROC) analysis, decision curve analysis (DCA), and the concordance index (C-index) were carried out to assess the accuracy of the prognostic risk model and nomogram. Potential molecular mechanisms were revealed by gene set enrichment analysis (GSEA). Additionally, gene correlation analysis and immune cell correlation analysis were conducted for further enriching our results. <b>Results:</b> A novel HNSCC prognostic model was established based on the nine genes (GTSE1, LRRN4CL, CRYAB, SHOX2, ASNS, KRT23, ANGPT2, HOXA9, and CARD11). The value of area under the ROC curves (AUCs) (0.769, 0.841, and 0.816) in TCGA whole set showed that the model effectively predicted the 1-, 3-, and 5-year overall survival (OS). Results of the Cox regression assessment confirmed the nine-gene signature as a reliable independent prognostic factor in HNSCC patients. The prognostic nomogram developed using multivariate Cox regression analysis showed a superior C-index over other clinical signatures. Also, the calibration curve had a high level of concordance between estimated OS and the observed OS. This showed that its clinical net can precisely estimate the one-, three-, and five-year OS in HNSCC patients. The gene set enrichment analysis (GSEA) to some extent revealed the immune- and tumor-linked cascades. <b>Conclusion:</b> In conclusion, the TME-related nine-gene signature and nomogram can effectively improve the estimation of prognosis in patients with HNSCC.
Nonenzymatic anticoagulant activity of the mutant serine protease Ser360Ala‐activated protein C mediated by factor Va (1997)

The human plasma serine protease, activated protein C (APC), primarily exerts its anticoagulant function by proteolytic inactivation of the blood coagulation cofactors Va and VIIIa. A recombinant active site Ser 360 to Ala mutation of protein C was prepared, and the mutant protein was expressed in human 293 kidney cells and purified. The activation peptide of the mutant protein C zymogen was cleaved by a snake venom activator, Protac C, but the "activated" S360A APC did not have amidolytic activity. However, it did exhibit significant anticoagulant activity both in clotting assays and in a purified protein assay system that measured prothrombinase activity. The S360A APC was compared to plasma-derived and wild-type recombinant APC. The anticoagulant activity of the mutant, but not native APC, was resistant to diisopropyl fluorophosphate, whereas all APCs were inhibited by monoclonal antibodies against APC. In contrast to native APC, S360A APC was not inactivated by serine protease inhibitors in plasma and did not bind to the highly reactive mutant protease inhibitor M358R alpha 1 antitrypsin. Since plasma serpins provide the major mechanism for inactivating APC in vivo, this suggests that S360A APC would have a long half-life in vivo, with potential therapeutic advantages. S360A APC rapidly inhibited factor Va in a nonenzymatic manner since it apparently did not proteolyze factor Va. These data suggest that native APC may exhibit rapid nonenzymatic anticoagulant activity followed by enzymatic irreversible proteolysis of factor Va. The results of clotting assays and prothrombinase assays showed that S360A APC could not inhibit the variant Gln 506-FVa compared with normal Arg 506-FVa, suggesting that the active site of S360A APC binds to FVa at or near Arg 506.
1A1-G10 A Coordinated System of Multiple Robots for Transportation of a Car -iCART- : 1st Report: Multiple Robot Systems Specialized for Transportation of a Car (2008)

We propose a new car trasnportation system called iCART(intelligent Cooperative Autonomous Robot Transporters). This system is composed with two robot systems specialized for the car transportation. Robot systems are controlled by using a decentralized control algorithm for transporting the car in coordination. This car trasnportation system can transport any size of car, and is available for any kind of car transportations: parking, ballet parking, tow away service, and the transportation of cars at a factory, ferry, parking area, etc. The robot system of the car transportation system is composed with three modules: Mobile Base module, Lifter module and Connecting module. This paper describes details of mechanism of each module to transport the car. Experimental results illustrate the validity of the car transportation system.
Nuclear oncoprotein expression as a function of lineage, differentiation stage, and proliferative status of normal human hematopoietic cells (1989)

Relative levels of the nuclear oncoproteins c-myb, c-myc, and c-fos were determined in selected subpopulations of normal human bone marrow (BM) cells using a flow cytometric assay which simultaneously detects a cell-surface antigen (as a marker of lineage and stage of maturation) and levels of an intracellular protein. At least two monoclonal antibodies directed against each oncoprotein and specific peptide inhibition controls were used for these determinations. Hematopoietic progenitor cells (CD34+) express the highest levels of c-myb and c-myc, whereas c-fos levels in CD34+ progenitor cells are similar to c-fos levels in mature monocytes and granulocytes. Granulocytes are the only hematopoietic cells examined which do not express detectable levels of c-myb and c-myc. The levels of these oncoproteins in these normal, unstimulated BM cell populations were more closely linked to lineage and maturation stage than to the proliferative status of the given population, as determined by either DNA staining or expression of the cell-cycle specific nuclear protein, Ki67. This flow cytometric assay helps in interpreting the significance of oncoprotein levels in leukemia cells by allowing direct comparisons of a leukemia with the phenotypically similar "normal counterpart control" cell population in normal BM.
Thermostable poly(<i>p</i>‐phenylene sulfide sulfonic acid) as ion exchangers (1994)

Abstract Poly(p‐phenylene sulfide sulfonic acid) was thermally crosslinked for use as a cation exchange polymer with high thermal stability. The decomposition temperature (T d ) of the polymer increases with an increase in the crosslinking temperature. The crosslinking reaction at 300°C in air resulted in the formation of a strongly acidic cation exchange polymer with a T = 467°C and having an SO 2 bond, whose crosslinked structure was investigated using IR spectroscopy.
Lignin Bioproducts to Enable Biofuels (2015)

Here we report that today's and tomorrow's biofuels production facilities could benefit tremendously from increasing the value from the large amount of lignin that results from biofuels operations. Certainly, the scientific community, and biofuels industry has begun to recognize the challenges and opportunities associated with lignin.
Valid mould and process design to cast tensile and fatigue test bars in tilt pour casting process (2011)

Tilt pour gravity casting technology is increasingly being used for shape casting various components with aluminium alloys. The ASTM B108/B108M-08 standard exists for a metal mould to evaluate the mechanical properties of castings made by gravity permanent mould process, yet there is no standard mould for the tilt pour process. We have designed, developed, tested and validated a standard mould to cast tensile and fatigue test bars in a tilt pour casting process. The new mould has demonstrated abilities to cast sound castings of A356·2 aluminium alloy, and the uniaxial tensile properties were superior to those obtained from conventional direct pour gravity casting process.
How to Interpret the Reflected Laser Probe Signal of Multiple Elementary Substructures in Very Deep Submicron Technologies (2013)

Abstract The constant size reduction of the elementary structures in integrated circuits (ICs) and their increasing complexity pushes laser probing techniques to their limits. For old technologies these techniques were powerful tools in defects detection and internal analysis, but now the major limitations of the laser spot size implies the understanding of the complex information contained in the reflected beam when it covers an area of multiple elementary structures. Knowing the contribution of each elementary structure covered by the laser spot in the reflected laser beam is the key to have a good analysis and interpretation of the probed area. In this paper we will expose the different parameters that modify the intensity of a laser beam and the contribution of a basic structure covered by a big laser spot size as well as the systematic approach we have built to deal with this challenging reflected laser probe signal from multiple elementary substructures in very deep submicron technologies.
Vector Signal Characterization of High-Speed Optical Components by Use of Linear Optical Sampling With Milliradian Resolution (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> We demonstrate linear optical sampling measurements optimized for characterization of the signals produced by optical components. By sampling the optical electric field before and after the component, we isolate the full vector field (phase and amplitude) of the signal separate from the input laser drift. Synchronization of the low-jitter mode-locked sampling laser (e.g., frequency comb) with the modulation rate allows measurement of the phase with milliradian noise. As a demonstration, we measure 10-Gb/s differential phase-shift keying modulated data with several different lasers. The technique is readily scalable to systems of much higher bandwidth. </para>
Zielsystem zur Berücksichtigung der Anlaufsituation (2015)

Kurzfassung Der Erfolg eines Produktionsanlaufs wird maßgeblich durch die eingesetzten Fertigungstechnologien beeinflusst. Gleichzeitig spielt der Produktionsanlauf in bestehenden Arbeiten zur Bewertung und Auswahl von Technologien nur eine untergeordnete Rolle. Aus diesem Grund wird in dem vorliegenden Beitrag ein Zielsystem entwickelt, das eine Bewertung von Fertigungstechnologien im Hinblick auf den Anlauf ermöglicht und somit die vorliegende Anlaufsituation bei der Technologieauswahl berücksichtigt.
Self‐medication of regular headache: a community pharmacy‐based survey (2012)

This study identified underdiagnosis of migraine, low use of migraine prophylaxis and triptans, and high prevalence of medication overuse amongst subjects seeking self-medication for regular headache. Community pharmacists have a strategic position in education and referral of these self-medicating headache patients.
Anomalous effects in measurements of rotational barriers in formamidinium ions. Influence of solvent, counter‐ion and concentration (1979)

Abstract Chemical exchange studies on the tetramethylformamidinium ion lead to anomalous values for the Arrhenius parameters of internal rotation when apolar solvents, high concentrations and nucleophilic anions are used. The deviations cannot be ascribed to ion‐pairing, and might be due to covalent bonding.
Characterization of a monoclonal antibody cocktail for human rabies prophylaxis (2011)

Rabies continues to kill many thousands of people throughout the developing world every year. The murine monoclonal antibody (mAb) 62-71-3 was recently identified for its potential application in rabies post-exposure-prophylaxis (PEP). The purpose here was to establish a plant-based production system for a chimeric mouse-human version of mAb 62-71-3, to characterize the recombinant antibody and investigate at a molecular level its interaction with the rabies virus (RV) glycoprotein. The chimeric mAb 62-71-3 was successfully expressed in Nicotiana benthamiana and functionality was analyzed by antigen binding ELISA and by neutralization of a panel of lyssavirus pseudotypes. The antibody-antigen interaction was investigated using pseudotype virus expressing mutagenized RV glycoproteins. A critical role for antigenic site I of the glycoprotein, in particular for two specific amino acid residues, was identified.
Influence of delayed isotopic equilibration in urine on the accuracy of the <sup>2</sup>H<sub>2</sub> <sup>18</sup>O method in the elderly (2002)

Isotopic determination of total energy expenditure (TEE) by the doubly labeled water (DLW) method may be affected by urine retention in the elderly. The isotopic enrichments in urine and plasma sampled simultaneously 4 h post-DLW dose were compared in a subset of 281 subjects [139 women, 142 men, 75 +/- 3 (SD) yr] of the 3,075 participants in the Health, Aging, and Body Composition study. Based on analytic precisions, a +/- 2% urine-plasma difference was set as the cut-off value. Ten percent of the population presented a difference lower than -2%, suggesting a delay in urine isotopic equilibration. This -13 +/- 10% urine-plasma difference was not linked to analytic errors, illnesses, the sampling time, or the time and quantity of water intake, suggesting that urine retention may be the main factor. The consequences are an 18 +/- 13 and 21 +/- 16% overestimation of the total body water and the TEE, respectively. Unexpectedly, 21% of the population presented a urine-plasma difference higher than +/- 2% that resulted, however, in a nonsignificant TEE underestimation of -3 +/- 5%. In conclusion, the delayed isotopic equilibration observed in urine reduces the accuracy of the DLW method in the elderly. It is recommended, when blood sampling is impossible, to adopt the intercept method with urine sampling 24 h postdose.
A simulation-based performance evaluation of Wireless Networked Control Systems (2009)

A wireless networked control system exploits a shared wireless network to logically link its sub-systems. Due to the peculiarities of the wireless channel, it is important to understand in which measure the quality of service provided by the communication infrastructure affects the quality of control. The aim of this work is to analyze the performance of a wireless networked control system based on the IEEE 802.11 MAC. For that purpose, a model of such a system has been built using the ns-2 simulator and the impact of MAC parameters on the system dynamics has been evaluated. Simulation results have highlighted strengths and limitations of this kind of wireless networked control system.
TU‐C‐12A‐08: Thermally‐Stabilized Isotropic Diffusion Phantom for Multisite Assessment of Apparent Diffusion Coefficient Reproducibilty (2014)

Purpose: To construct an appropriate phantom for quality control use in diffusion‐weighted imaging (DWI), to establish ground truth for measurement of apparent diffusion coefficient (ADC) and to characterize measurement linearity across a relevant physiological range of ADC. Methods: Aqueous solutions containing the polymer polyvinylpyrrolidone (PVP) were mixed at concentrations of 0, 10, 20, 30, 40 and 50% by mass PVP. These solutions were placed in 20 mL vials, arranged in concentric inner and outer circles, with a central water vial, and were fixed in a spherical phantom with a diameter of 194 mm, designed to fit into commercially‐available MRI head coils. Two prototype phantoms were constructed, and underwent inter‐site comparison in the US and EU. The phantoms were filled with an ice‐water bath to ensure stable temperature; 0 °C temperature was verified by use of a thermocouple before and after scans. The phantoms were scanned using b‐values of 0, 500 and 900 s/mm 2 at several sites, using coronal and/or axial orientations and scan planes. Results: ADC values ranged from 0.12 to 1.12 × 10 ‐3 mm 2 /s, and exhibited a high degree of reproducibility across different scanners and imaging sites (coefficient of variations (CoV) ranged from 1.1 to 2.2% for 0 to 40% PVP, with 50% PVP at 11.3%). Little difference in ADCs was seen between inner and outer ring vials of the same PVP concentration (average CoV&lt; 5% across vials, 10.3% for 50% PVP). Conclusion: The range of ADCs covers a relevant physiological range, most notably in brain white matter. The ADCs of water vials were in excellent agreement with literature values of the diffusion coefficient of water at 0 °C (1.1 × 10 ‐3 mm 2 /s). The phantom provides a much needed quality control tool for DWI, and provides ground truth with the diffusion coefficient of water at 0 °C.
Sequence-Specific Biosensors Report Drug-Induced Changes in Epigenetic Silencing in Living Cells (2020)

Treatment with demethylating drugs can induce demethylation and reactivation of abnormally silenced tumor suppressor genes in cancer cells, but it can also induce potentially deleterious loss of methylation of repetitive elements. To enable the observation of unwanted drug effects related to loss of methylation of repetitive DNA, we have developed a novel biosensor capable of reporting changes in DNA accessibility via luminescence, in living cells. The biosensor design comprises two independent modules, each with a polydactyl zinc finger domain fused to a half intein and to a split-luciferase domain that can be joined by conditional protein splicing after binding to adjacent DNA targets. We show that an artificial zinc finger design specifically targeting DNA sequences near the promoter region of the L1PA2 subfamily of Line-1 retroelements is able to generate luminescent signals, reporting loss of epigenetic silencing and increased DNA accessibility of retroelements in human cells treated with the demethylating drugs decitabine or 5-azacytidine.
Löschung der Fluoreszenz aromatischer Urethane durch Ketone (1982)

Fluorescence Quenching of N‐Arylurethanes by Ketones Fluorescence and photo‐Fries reaction of N‐aryl‐urethanes can be quenched by diffusion‐controlled energy transfer to biacetyl, acetone and other aliphatic ketones. Quenching of the photo reaction and fluorescence obeys the Stern‐ Volmer Equation. The efficiency of quenching may by influenced by solvents and substituents changing the S 1 energies of donors and acceptors. The identical rate constants determined by independent methods demonstrate that quenching of urethane fluorescence and photoreaction by aliphatic ketones occurs completely by singlet energy transfer.
Relacorilant With Pembrolizumab: A Phase 1b, Open-Label Study of a Selective Glucocorticoid Receptor Modulator Combined With a Checkpoint Inhibitor for Patients With Adrenocortical Carcinoma With Excess Glucocorticoid Production (2021)

Abstract Adrenocortical carcinoma (ACC) is an aggressive cancer with poor response to chemotherapeutic and immunotherapeutic agents. About half of ACCs produce glucocorticoids (GC), and the presence of GC excess (hypercortisolism) is correlated with decreased survival in patients with ACC. The broad immunosuppressive effects of GC may contribute to the limited efficacy of immune checkpoint inhibitors, such as pembrolizumab, in these patients. Antagonism of the glucocorticoid receptor (GR) has the potential to increase immune-related transcripts, thus promoting tumor immune response in ACC with GC excess. To test this hypothesis, we introduce a phase 1b study evaluating the combined treatment of relacorilant (CORT125134, Corcept Therapeutics) with pembrolizumab in patients with advanced ACC and hypercortisolism (NCT04373265). Relacorilant is a selective (no activity at other steroid receptors), oral GR modulator in development for Cushing syndrome and, in combination with chemotherapy, for various solid tumors. In healthy subjects, prednisone causes rapid reductions in eosinophils, lymphocytes, and osteocalcin and rapid increases in neutrophils. Relacorilant ameliorates these effects. In a phase 2 study in patients with endogenous Cushing syndrome treated with relacorilant, improvements in the signs and symptoms of GC excess were seen. The primary objective of this study is to determine the safety and efficacy of the recommended regimen of relacorilant with pembrolizumab in patients with advanced ACC and hypercortisolism. Pembrolizumab infusion will occur on day 1 of each 21-day cycle, and relacorilant will be administered once daily, starting 3 days before the first pembrolizumab infusion. Relacorilant doses will be escalated in 100-mg increments (100 mg up to 400 mg, as tolerated). Patients will receive treatment until they experience disease progression or unacceptable toxicity. Approximately 20 adults with confirmed advanced, unresectable and/or metastatic ACC will be enrolled. GC excess must be documented by either ACTH &amp;lt;10 pg/mL and serum cortisol &amp;gt;1.8 µg/dL after dexamethasone suppression testing (DST), or the presence of two of the following criteria: elevated urinary free cortisol; high late-night salivary cortisol; and DST cortisol &amp;gt;1.8 µg/dL. Assessments will include safety, tolerability, and efficacy. Secondary objectives include a determination of the non-progression rate at 27 weeks, evaluation of progression-free survival, overall survival, duration of response, and an assessment of the effect of the combination on clinical manifestations of hypercortisolism. This will be the first clinical study to evaluate whether GR antagonism promotes tumor response in patients with ACC and GC excess treated with checkpoint inhibitors.
Reactivity of palladium nanoparticles supported in hydrogenation: role of the particle surface density (2004)

SSCI-VIDE+CARE+CDS