gebhart/patrepeval huggingface dataset:
The Uranium Deposits of T&amp;ocirc;g&amp;ocirc; Mine of Ningy&amp;ocirc;-t&amp;ocirc;ge Uranium Field (1963)

In the area of Tôgô mine and its vicinity of the Ningyô-tôge uranium field, there are three types of granite, namely Okutsu, Ningyô-tôge, and Ogamo. Nearly horizontally stratified strata of Misasa group of Neogene Tertiary lie uncomformably on these granites and this group has three cycles on the point of volcano-stratigraphy. Uranium has been deposited in the lower beds of Misasa group, and its location is controlled by the so-called channel structure on the surface of unconformity of the granites. Uranium is mainly found in basal conglomerate and arkose, and rarely in shale and tuff etc. Ore grade is 0.07-0.10% U3O8.Several uranium minerals are found, namely ningyôite, uraninite, and coffinite as the primary minerals and autunite and β-uranophane, etc. as the secondary minerals.It is thought that these uranium deposits are epigenetic and uranium was deposited from the underground water.
Updated results from DIAMOND-01 (CLI24-001) trial: A phase I/II study of SEL24/MEN1703, a first-in-class dual PIM/FLT3 kinase inhibitor, in acute myeloid leukemia. (2021)

7023 Background: SEL24/MEN1703, a dual PIM/FLT3 kinase inhibitor, in the dose escalation (DE) DIAMOND-01 trial (CLI24-001, NCT03008187), showed an acceptable safety profile up to the recommended dose (RD) of 125 mg along with initial evidence of single agent activity and meaningful target engagement in heavily pre-treated patients (pts) with AML (Solomon et al, EHA 2020; Tomirotti et al, ASH 2020). Here we present updated data including pts enrolled in the Phase II, cohort expansion (CE) of the study. Methods: DIAMOND-01 trial enrolled pts unsuitable for chemotherapy having relapsed or refractory (R/R) (DE and CE) or previously untreated (DE) AML. Previous targeted therapies – except PIM inhibitors – were allowed. SEL24/MEN1703 was given orally, QD, 14 days ON / 7 days OFF until progression/unacceptable toxicity. The DE tested MEN1703 escalating doses from 25 to 150 mg, whereas in the CE the RP2D (125 mg) was administered. The key objectives of the CE were the confirmation of the safety profile determined in the DE along with further investigation of single agent activity. Adverse events (AEs) were graded according to NCI-CTCAE v.4.03; responses assessed as per ELN 2017 criteria. Results: As of January 21, 2021 (cut-off date), n = 48 pts were treated across DE (n = 25) and CE (n = 23). Median age was 69 (25-84) years. Overall, 20 (43%) and 15 (32%) pts had non de novo AML and primary refractory AML, respectively. Adverse karyotype was reported in 7 (15%) pts. Most frequently reported mutations were FLT3/ITD (23%, n = 11), DNMT3A (15% n = 7), NPM1 (15%, n = 7), IDH1 (13%, n = 6) and IDH2 (4%, n = 2), CEBPA (4%, n = 2), FLT3/TKD (2%, n = 1). Median number of cycles was 2 (1-8). At the RD (n = 30), most frequent serious treatment-emergent AEs (serious TEAEs) were pneumonia (23%), sepsis and febrile neutropenia (13%) and pulmonary mycosis (10%) whereas most frequent G≥3 TEAEs were febrile neutropenia and pneumonia (23%), leukocytosis (20%) and neutrophil count decrease, platelet count decrease, lymphocyte count decrease and sepsis (13%). Responses occurred in 2 pts in the CE, both with IDH1 mutant disease (naïve to IDH inhibitors) who achieved complete remission with incomplete hematologic recovery (CRi). Both responses occurred by Cycle 3, with a duration of 79 (ongoing at cut-off date) and 43 days, respectively. Across DE and CE, 4 CR/CRi occurred, three of which in pts with IDH mutations. A total of 3 out of 6 pts with IDH mutations treated at doses ≥75 mg achieved CR/CRi, including a CR in a patient with IDH2 mutant AML relapsed on Enasidenib. Conclusions: SEL24/MEN1703 confirmed a manageable safety profile at RD and showed preliminary single agent efficacy in R/R AML, particularly clustering in pts with IDH mutant disease either naïve or previously exposed to IDH inhibitors. These results warrant further investigation of SEL24/MEN1703 in AML, with potential focus in the IDH mutated subset. Clinical trial information: NCT03008187.
Pseudoaneurysm of aortocoronary graft secondary to spontaneous late rupture (2006)

A 79-year-old man with a prior history of three-vessel coronary artery bypass graft surgery performed 14 years ago was admitted for chest pain radiating into the back. Chest x …
Correction: Inhibitory Activity of Bevacizumab to Differentiation of Retinoblastoma Cells (2012)

Vascular endothelial growth factor (VEGF) is a major regulator in retinal and choroidal angiogenesis, which are common causes of blindness in all age groups. Recently anti-VEGF treatment using anti-VEGF antibody has revolutionarily improved the visual outcome in patients with vaso-proliferative retinopathies. Herein, we demonstrated that bevacizumab as an anti-VEGF antibody could inhibit differentiation of retinoblastoma cells without affection to cellular viability, which would be mediated via blockade of extracellular signal-regulated kinase (ERK) 1/2 activation. The retinoblastoma cells expressed VEGFR-2 as well as TrkA which is a neurotrophin receptor associated with differentiation of retinoblastoma cells. TrkA in retinoblastoma cells was activated with VEGF treatment. Interestingly even in the concentration of no cellular death, bevascizumab significantly attenuated the neurite formation of differentiated retinoblastoma cells, which was accompanied by inhibition of neurofilament and shank2 expression. Furthermore, bevacizumab inhibited differentiation of retinoblastoma cells by blockade of ERK 1/2 activation. Therefore, based on that the differentiated retinoblastoma cells are mostly photoreceptors, our results suggest that anti-VEGF therapies would affect to the maintenance or function of photoreceptors in mature retina.
Self-aligned optofiber/waveguide connector with integrated V-grooves and diffractive optical elements (2003)

We demonstrate a novel type of self-aligned optofiber/waveguide connector with integrated V-grooves and diffractive optical elements. The self-alignment is achieved by connecting micro-structures which have originally been formed in silicon and later replicated in concave and convex forms. V-grooves hold the optical fibers and the light is coupled out through diffractive optical elements (DOEs). A manufacturing process has been developed which allows both deep micro-structures (V-grooves and alignment structures) and shallow surface reliefs (diffractive elements) to be realized on the same substrate. The self-alignment using microstructures allows a positioning accuracy of about &plusmn;5&mu;m. Two different fan-out DOEs have been optically characterized.
Mechanically Strong Lightweight Materials for Aerospace Applications (X-Aerogels) (2005)

The X-Aerogel is a new NASA-developed strong lightweight material made by reacting the mesoporous surfaces of 3-D networks of inorganic nanoparticles with polymeric crosslinkers. Since the relative amount of the crosslinker and the backbone are comparable, X-Aerogels can be viewed either as aerogels modified by templated accumulation of polymer on the skeletal nanoparticles, or as nanoporous polymers made by templated casting of polymeric precursors on a nanostructured framework. The most striking feature of X-Aerogels is that for a nominal 3-fold increase in density (still a ultralightweight material), the mechanical strength can be up to 300 times higher than the strength of the underlying native aerogel. Thus, X-Aerogels combine a multiple of the specific compressive strength of steel, with the thermal conductivity of styrofoam. XAerogels have been demonstrated with several polymers such as polyurethanes/polyureas, epoxies and polyolefins, while crosslinking of approximately 35 different oxide aerogels yields a wide variety of dimensionally stable, porous lightweight materials with interesting structural, magnetic and optical properties. X-Aerogels are evaluated for cryogenic rocket fuel storage tanks and for Advanced EVA suits, where they will play the dual role of the thermal insulator/structural material. Along the same lines, major impact is also expected by the use of X-Aerogels in structural components/thermal protection for small satellites, spacecrafts, planetary vehicles and habitats.
Head gesture recognition in intelligent interfaces (2006)

Acknowledging an interruption with a nod of the head is a natural and intuitive communication gesture which can be performed without significantly disturbing a primary interface activity. In this paper we describe vision-based head gesture recognition techniques and their use for common user interface commands. We explore two prototype perceptual interface components which use detected head gestures for dialog box confirmation and document browsing, respectively. Tracking is performed using stereo-based alignment, and recognition proceeds using a trained discriminative classifier. An additional context learning component is described, which exploits interface context to obtain robust performance. User studies with prototype recognition components indicate quantitative and qualitative benefits of gesture-based confirmation over conventional alternatives.
Modification of PETI-5K Imide Oligomers: Effect on Viscosity (2003)

A phenylethynyl (PE) end-capped oligoimide of number average molecular weight M n 5000, known as PETI-5K was modified by: (1) varying molecular weight; (2) addition of phenylethynyl (PE) end-capped reactive diluents to PETI oligomides; (3) incorporation of 1,4-cyclohexanyl diamine with PETI-5K diamines; (4) incorporation of 2,4,5-triaminopyrimidine with PETI-5K; and (5) replacement of the PETI-5 diamines, 3,4′-ODA and APB with 2,2′-bis [4-(4-amino-phenoxy) phenyl] hexafluoropropane (4-BDAF) to determine the effects on glass transition temperature and minimum melt viscosity. All approaches caused a reduction in complex minimum melt viscosity, but the minimum melt temperatures were only sufficiently low enough for the material to have melt stability for a hot-melt coating application in methods (2), (4), and (5). The reduction in the complex minimum melt viscosity of oligomer prepared by method (4) may be due to unreacted monomers and a lower oligomer molecular weight, M n , than calculated.
From Chronic Wounds to Scarring: The Growing Health Care Burden of Under- and Over-Healing Wounds (2021)

<b>Significance:</b> Wound healing is the largest medical market without an existing small molecule/drug treatment. Both "under-healing" (chronic wounds) and "over-healing" (scarring) cause a substantial biomedical burden and lifelong consequences for patients. These problems cost tens of billions of dollars per year in the United States alone, a number expected to grow as the population ages and the prevalence of common comorbidities (<i>e.g.,</i> diabetes) rises. However, no therapies currently exist to produce the "ideal" healing outcome: efficient wound repair through regeneration of normal tissue. <b>Recent Advances:</b> Ongoing research continues to illuminate possible therapeutic avenues for wound healing. By identifying underlying mechanisms of wound repair-for instance, tissue mechanics' role in fibrosis or cell populations that modulate wound healing and scarring-novel molecular targets may be defined. This <i>Advances in Wound Care</i> Forum issue includes reviews of scientific literature and original research from the Hagey Laboratory for Pediatric Regenerative Medicine at Stanford and its alumni, including developing approaches for encouraging wound healing, minimizing fibrosis, and coaxing regeneration. <b>Critical Issues:</b> Wound healing problems reflect an enormous and rapidly expanding clinical burden. The issues of both under- and over-healing wound outcomes will continue to expand as their underlying causes (<i>e.g.,</i> diabetes) grow. Targeted treatments are needed to enable wound repair with functional tissue restoration and decreased scarring. <b>Future Directions:</b> Basic scientists will continue to refine understanding of factors driving undesirable wound outcomes. These discoveries are beginning to be translated and, in the coming years, will hopefully form the foundation for antiscarring drugs and other wound therapeutics.
Synthesis of Chiral Azacrown Ethers Derived from a-D-Glucose and Their Catalytic Properties on the Asymmetric Michael Addition (2001)

Three types of chiral azacrown ethers have been synthesized from (+)-(4,6-O-benzylidene)-O-methyl-α-D-glucopyranoside and their catalytic properties for the asymmetric Michael addition have been investigated; enantioselectivity switching which is dependent on the azacrown ether catalysts has been achieved.Development of a natural environmentally friendly catalyst for the asymmetric reaction is one of the current topics in recent organic synthesis; 1 several types of efficient catalysts derived from alkaloids 2 or chiral crown ethers 3 have been reported with their numerous applications. 2,3We are attracted by chiral azacrown ethers which were derived from sugars reported by Töke and his colleagues. 4We have previously demonstrated a simple method for resolving axially chiral biphenyldicarboxylic acids based on the kinetic controlled cyclic ester formation of racemic biphenyldicarboxylic acids with (+)-( 4,6-Obenzylidene)-O-methyl-α-D-glucopyranoside. 5 In the reaction, two adjacent hydroxyl groups at the 2and 3-positions on the glucoside had an important role in recognizing chirality.5b,6 MeO MeO O O Me O O O N O H MeO O O OMe OMe O O O N H Figure1. Results of MO(PM3) calculation of the optimized structure of two azacrown ethers 1a and 2a derived from α-D-Glucose 1a (2,3-type) 2a (3,4-type)Although no mechanistic detail for the origin of enantio-favoritism of Töke's sugar-type azacrown ether has been reported, we expected that opposite enantioselectivity could be seen between the 2,3-bridged
Passive West Nile Virus Antibody Transfer from Maternal Eastern Screech-Owls (Megascops asio) to Progeny (2006)

Transovarial antibody transfer in owls has not been demonstrated for West Nile virus (WNV). We sampled chicks from captive adult WNV-antibody-positive Eastern Screech-Owls (Megascops asio) to evaluate the prevalence of transovarial maternal antibody transfer, as well as titers and duration of maternal antibodies. Twenty-four owlets aged 1 to 27 days old circulated detectable antibodies with neutralizing antibody titers ranging from 20 to 1600 (median 1:40). Demonstrating that WNV antibodies are passively transferred transovarially is important for accurate interpretation of serologic data from young birds.
Two layer segmentation for handling pathological motion in degraded post production media (2005)

The paper presents a mechanism for dealing with incorrect motion estimation in degraded post production image sequences. This tends to be caused by pathological motion (a combination of motion blur, complex foreground motion, shadows, etc.). We describe a method for estimating where such regions are likely to occur by segmenting sequences into foreground and background motion. We show it is possible to produce a conservative matte of which regions in a sequence are foreground, and that blotch (dirt and sparkle defects) detection can be adapted accordingly in such areas.
From Macrohemodynamic to the Microcirculation (2013)

ICU patients need a prompt normalization of macrohemodynamic parameters. Unfortunately, this optimization sometimes does not protect patients from organ failure development. Prevention or treatment of organ failure needs another target to be pursued: the microcirculatory restoration. Microcirculation is the ensemble of vessels of maximum 100 μm in diameter. Nowadays the Sidestream Dark Field (SDF) imaging technique allows its bedside investigation and a recent round-table conference established the criteria for its evaluation. First, microcirculatory derangements have been studied in sepsis: they are mainly characterized by a reduction of vessel density, an alteration of flow, and a heterogeneous distribution of perfusion. Endothelial malfunction and glycocalyx rupture were proved to be the main reasons for the observed microthrombi, capillary leakage, leukocyte rolling, and rouleaux phenomenon, even if further studies are necessary for a better explanation. Therapeutic approaches targeting microcirculation are under investigation. Microcirculatory alterations have been recently demonstrated in other diseases such as hypovolemia and cardiac failure but this issue still needs to be explored. The aim of this paper is to gather the already known information, focus the reader's attention on the importance of microvascular physiopathology in critical illness, and prompt him to actively participate to achieve a more comprehensive understanding of the issue.
Ladder programs validation through model-code traceability (2011)

Control systems are used in industry for process automation and to increase the reliability and dependability when executing critical tasks. Failures in the operation of such systems may cause expensive losses and can compromise the plant safety. Therefore, it is necessary to define techniques, methods and tools to increase the dependability as well as reliability. Verification and validation techniques developed by the academy often excel in technical aspects but have little acceptance in industry due to the need of advanced knowledge in formal methods. The goal of this work is to introduce a user-friendly visual conformance validation method to increase the dependability of programmable logic controllers software. Also, a tool to hide formal aspects related to the implementation details from users during the test phase of Ladder programs without the need of specific training in formal methods.
Advanced multifocus confocal laser scanning microscope for single molecule studies (2005)

A new multi-focus multi-confocal set-up for performing fluorescence spectroscopy of single molecules in solution is presented. The ultimate goal of the set-up is to track individual molecules during diffusion in solution, when all standard methods of trapping such as optical tweezers or dielectrophoretic traps fail. We present here a detailed description of the experimental setup and show first experimental results.
O <sup>−</sup> dynamic Jahn-Teller polarons in KTaO <sub>3</sub> (2003)

It is analyzed how dynamic Jahn-Teller coupling of an O− hole with the surrounding lattice in oxide perovskites affects the electron paramagnetic resonance of shallow O− defects. The predicted unusual resonance parameters are seen to be realized by experimentally identified O− defects in KTaO3. These centers thus manifest the properties of dynamic Jahn-Teller hole polarons in oxide perovskites. By varying the strength of the Jahn-Teller coupling, a continuous transition to the static Jahn-Teller case is modelled. The latter situation describes the properties of O− polarons identified previously in other oxide perovskites.
”Walk-in” Interfaces and Internet Applications (2003)

Remember the airline reading light we discussed earlier? Well, as with everything, the machines that passengers interact with on today's airplanes have grown ever more complex. In this chapter, we look at the new personal entertainment system available on many aircraft. We start by pressing the video button on the personal control unit in the armrest (figure 9.1). The blank screen awakes with a flicker, but not much else. You hit the video button again but still nothing. That's not very entertaining. You play with the brightness controls thinking maybe that is the problem—but it's not. So you try every button, hoping that something might turn up on the screen. Not today.KeywordsBlank ScreenInternet ApplicationVideo ChannelMain MenuHistory SettingThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
High pulse repetition frequency ultra violet laser micro-machining of polymers and glasses (1997)

As the demand for smaller manufactured structures increases, the techniques for efficient and economical UV micromachining continue to draw more attention. In the paper we investigate UV micropatterning methods in PETG, glass, and aluminium, comparing the commonly used percussion drilling with the flexible direct write methods. Issues such as sample speed and material removal rates as well as the size of heat effected areas are discussed.
Photosensitive Writing and Erasing of Gratings in an As2S3 Chalcogenide Microresonator (2019)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text J. Zhu, M. Zohrabi, T. M. Horning, W. Park, and J. T. Gopinath, "Photosensitive Writing and Erasing of Gratings in an As2S3 Chalcogenide Microresonator," in Nonlinear Optics (NLO), OSA Technical Digest (Optica Publishing Group, 2019), paper NF2A.4. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Leveraging MapReduce and Synchrophasors for Real-Time Anomaly Detection in the Smart Grid (2017)

The rapid detection of anomalous behavior in SCADA systems such as the U.S. power grid is critical for system resiliency and operator response in cases of power fluctuations due to hazardous weather conditions or other events. Phasor measurement units are time synchronized devices that provide accurate synchrophasor measurements in power grids. The rapid deployment of PMUs enable improved real-time situational awareness to grid operators through wide area measurement systems. However, the quantity and rate of measurements obtained from PMUs is significantly higher than traditional devices, and continues to grow as more are deployed. Efficient algorithms for processing large-scale PMU data and notifying operators of anomalies is critical for real-time system monitoring. In this paper, we propose a novel, two-step anomaly detection approach that processes raw PMU data using the MapReduce paradigm. We implement our approach on a multicore system to process a dataset derived from real PMUs containing 4,500 PMUs (~18 million measurements). Our experimental results indicate the proposed approach detects constraint and temporal anomalies in under three seconds on 8 cores. Our work demonstrates the applicability of MapReduce for designing anomaly detection algorithms for the smart grid, and motivates the creation of novel MapReduce approaches for other SCADA applications.
MODAL ANALYSIS OF RECTANGULAR WAVEGUIDES WITH 2D METAMATERIALS (2016)

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Epstein-Barr Virus Infection and Altered Control of Apoptotic Pathways in Posttransplant Lymphoproliferative Disorders (2012)

Posttransplant lymphoproliferative disorders (PTLD) represent a spectrum of lymphoid diseases complicating the clinical course of transplant recipients. Most PTLD are Epstein-Barr virus (EBV) associated with viral latency type III. Several in vitro studies have revealed an interaction between EBV latency proteins and molecules of the apoptosis pathway. Data on human PTLD regarding an association between Bcl-2 family proteins and EBV are scarce. We analyzed 60 primary PTLD for expression of 8 anti- (Bcl-2, Bcl-XL, and Mcl-1) and proapoptotic proteins (Bak and Bax), the so-called BH3-only proteins (Bad, Bid, Bim, and Puma), as well as the apoptosis effector cleaved PARP by immunohistochemistry. Bim and cleaved PARP were both significantly (p = 0.001 and p = 5.251e-6) downregulated in EBV-positive compared to EBV-negative PTLD [Bim: 6/40 (15%), cleaved PARP: 10/43 (23%), vs. Bim: 13/16 (81%), cleaved PARP: 12/17 (71%)]. Additionally, we observed a tendency toward increased Bcl-2 protein expression (p = 0.24) in EBV-positive PTLD. Hence, we provide evidence of a distinct regulation of Bcl-2 family proteins in EBV-positive versus negative PTLD. The low-expression pattern of the proapoptotic proteins Bim and cleaved PARP together with the high-expression pattern of the antiapoptotic protein Bcl-2 by trend in EBV-positive tumor cells suggests disruption of the apoptotic pathway by EBV in PTLD, promoting survival signals in the host cells.