gebhart/patrepeval huggingface dataset:
FAK induces expression of Prx1 to promote tenascin-C–dependent fibroblast migration (2003)

Fibroblast migration depends, in part, on activation of FAK and cellular interactions with tenascin-C (TN-C). Consistent with the idea that FAK regulates TN-C, migration-defective FAK-null cells expressed reduced levels of TN-C. Furthermore, expression of FAK in FAK-null fibroblasts induced TN-C, whereas inhibition of FAK activity in FAK–wild-type cells had the opposite effect. Paired-related homeobox 1 (Prx1) encodes a homeobox transcription factor that induces TN-C by interacting with a binding site within the TN-C promoter, and it also promotes fibroblast migration. Therefore, we hypothesized that FAK regulates TN-C by controlling the DNA-binding activity of Prx1 and/or by inducing Prx1 expression. Prx1–homeodomain binding site complex formation observed with FAK–wild-type fibroblasts failed to occur in FAK-null fibroblasts, yet expression of Prx1 in these cells induced TN-C promoter activity. Thus, FAK is not essential for Prx1 DNA-binding activity. However, activated FAK was essential for Prx1 expression. Functionally, Prx1 expression in FAK-null fibroblasts restored their ability to migrate toward fibronectin, in a manner that depends on TN-C. These results appear to be relevant in vivo because Prx1 and TN-C expression levels were reduced in FAK-null embryos. This paper suggests a model whereby FAK induces Prx1, and subsequently the formation of a TN-C–enriched ECM that contributes to fibroblast migration.
VIABLE ISLET DOSE BASED ON OXYGEN CONSUMPTION RATE PREDICTS CLINICAL ISLET AUTOTRANSPLANT OUTCOME (2010)

Papas, K. K.1; Bellin, M.1; Sutherland, D. E.1; Mueller, K.2; Avgoustiniatos, E. S.1; Balamurugan, A. N.3; Rozak, P. R.1; Loganathan, G. L.1; Qian, D.4; Niland, J. C.4; Hering, B. J.1 Author Information
Table S1 from Demethylation Therapy as a Targeted Treatment for Human Papillomavirus–Associated Head and Neck Cancer (2023)

&lt;p&gt;qRT-PCR primers used in the study&lt;/p&gt;
Helix oscillation of polyacetylene esters detected by dynamic 1H NMR, IR, and UV-vis methods in solution (2013)

An aliphatic substituted acetylene, n-heptyl propiolate, was stereoregularly polymerised using a catalyst, [Rh(nbd)Cl]2, at 40 °C in methanol to obtain the corresponding helical polymer, PnHepP. The changes in the line shapes and splitting patterns of the 1H NMR spectra were interpreted consistently as representing restricted rotation around the ester O–Cε bond in –O–CεHε2(R)– (R = n-hexyl alkyl chains), rather than helix inversion, with the aid of a 3-site jump model. A two-line peak corresponding to the ester methylene protons of –O–CH2– observed at 30 °C suggested the formation of three rotamers designated as A, B, and C based on the presence of contracted helix and stretched helix forms, each of which has an intrinsic helical pitch with a helical cis–cisoid structure. Furthermore, an accordion-like helix oscillation (HELIOS) along the main chain axis was proposed to explain the temperature dependence of spectral changes observed in the 1H NMR, UV-vis, and IR spectra. The temperature dependence of the UV-vis and 1H NMR spectra of PnHepP corroborated the presence of contracted and stretched one-handed helix sense polymers in solution.
Synthesis and Crystal Structures of New 5,5'-Azotetrazolates (2012)

Five new 5,5'-azotetrazolate salts (amminsilver, trimethylsulfonium, tetramethyl-phosphonium, trimethylsulfoxonium, 2-(hydroxyethyl)trimethylammonium) were prepared and characterized. The crystal structures were determined by X-ray diffraction. Interactions between the ions are identified and discussed. The sensitivities of the highly energetic silver salt were measured by BAM (Bundesanstalt für Materialforschung und-prüfung) methods.
Semiautomatic seismic well ties and log data interpolation (2017)

The seismic to well tie typically involves a subjective, labor-intensive, workflow that depends on the interpreter’s experience and intuition. Therefore, quality checking multiple seismic well ties for consistency remains a challenge. We propose an approach that automatically ties wells to seismic data and generates a global log property volume using available log data. We first use local similarity to tie available wells with seismic data. Log data from each well is then interpolated along the local seismic structure to generate a global property volume. The accuracy of a seismic well tie can be verified by removing single or multiple wells from the method and performing a blind well test. We apply this method to a 3D seismic data set with several wells and achieve consistent and verifiably accurate seismic well ties. Presentation Date: Wednesday, September 27, 2017 Start Time: 10:35 AM Location: Exhibit Hall C/D Presentation Type: POSTER
Accelerometer Modeling in the State-Space (2021)

Generically, accelerometers are sensors that measure the accelerating force applied to an object. Their operation is based on a simple mechanical system and D’Alembert’s force principle along with Newton’s laws of motion. This device is typically mounted to the body of the test object under investigation that is subjected to an accelerating force. The displacement of the seismic or “proof” mass due to the acceleration is sensed by an embedded component from which the acceleration is determined. Interestingly enough, the resulting the resulting mathematical relations governing the dynamical motion is based on the underlying physics, sensor materials, geometry and fabrication. Mathematically, the various designs satisfy the underlying Newtonian equations of motion, but their type and performance differ significantly.
Supplementary Figure S7 from Early On-treatment Changes in Circulating Tumor DNA Fraction and Response to Enzalutamide or Abiraterone in Metastatic Castration-Resistant Prostate Cancer (2023)

&lt;p&gt;On-treatment ctDNA fraction, PSA responses and baseline genomic and clinical features&lt;/p&gt;
Desempenho reprodutivo de borregas da raça Suffolk criadas com suplementação em comedouro privativo (2011)

Com o objetivo de avaliar o efeito dos níveis de suplementação com concentrado contendo 25 % de PB e 3,18 Mcal EM kg-1 MS-1 para cordeiras em pastagem com comedouro privativo sobre o peso e desempenho em distintas idades, início da puberdade e desempenho reprodutivo, foram utilizadas 21 cordeiras Suffolk, divididas em três lotes, sem e com suplementação, alimentadas do nascimento ao desmame com dois níveis de ingestão de concentrado (300 e 600g dia-1) fornecido uma vez ao dia com o registro das sobras diárias. As cordeiras foram identificadas, pesadas ao nascimento e a cada 30 dias, sendo desmamadas aos 60 dias. Não houve diferença significativa para peso e ganho médio de peso diário aos 30 dias de idade. O peso e ganho médio de peso diário foram influenciados pelo nível de suplementação alimentar. O lote com consumo de 600 g mostrou desempenho superior aos demais lotes aos 60 e 120 dias de idade. Para os lotes de 300 gramas e sem suplementação não houve diferença para os parâmetros analisados. A disponibilidade de 600 g diários de concentrado para as cordeiras até o desmame promoveu maior ganho médio de peso diário aos 60 e 120 dias de vida e melhor desempenho reprodutivo no segundo ano de cobertura.
Crowdsourcing Truth Inference via Reliability-Driven Multi-View Graph Embedding (2022)

Crowdsourcing truth inference aims to assign a correct answer to each task from candidate answers that are provided by crowdsourced workers. A common approach is to generate workers’ reliabilities to represent the quality of answers. Although crowdsourced triples can be converted into various crowdsourced relationships, the available related methods are not effective in capturing these relationships to alleviate the harm to inference that is caused by conflicting answers. In this research, we propose a Re liability-driven M ulti-view G raph E mbedding framework for T ruth i nference (TiReMGE), which explores multiple crowdsourced relationships by organically integrating worker reliabilities into a graph space that is constructed from crowdsourced triples. Specifically, to create an interactive environment, we propose a reliability-driven initialization criterion for initializing vectors of tasks and workers as interactive carriers of reliabilities. From the perspective of multiple crowdsourced relationships, a multi-view graph embedding framework is proposed for reliability information interaction on a task-worker graph, which encodes latent crowdsourced relationships into vectors of workers and tasks for reliability update and truth inference. A heritable reliability updating method based on the Lagrange multiplier method is proposed to obtain reliabilities that match the quality of workers for interaction by a novel constraint law. Our ultimate goal is to minimize the Euclidean distance between the encoded task vector and the answer that is provided by a worker with high reliability. Extensive experimental results on nine real-world datasets demonstrate that TiReMGE significantly outperforms the nine state-of-the-art baselines.
A Change-Detection Based Framework for Piecewise-Stationary Multi-Armed Bandit Problem (2018)

The multi-armed bandit problem has been extensively studied under the stationary assumption. However in reality, this assumption often does not hold because the distributions of rewards themselves may change over time. In this paper, we propose a change-detection (CD) based framework for multi-armed bandit problems under the piecewise-stationary setting, and study a class of change-detection based UCB (Upper Confidence Bound) policies, CD-UCB, that actively detects change points and restarts the UCB indices. We then develop CUSUM-UCB and PHT-UCB, that belong to the CD-UCB class and use cumulative sum (CUSUM) and Page-Hinkley Test (PHT) to detect changes. We show that CUSUM-UCB obtains the best known regret upper bound under mild assumptions. We also demonstrate the regret reduction of the CD-UCB policies over arbitrary Bernoulli rewards and Yahoo! datasets of webpage click-through rates.
Interview: From Traditional Polymer Science to Nanomedicine: The Interplay Between Disciplines to Drive Innovation (2012)

Professor Joseph DeSimone speaks to Hannah Stanwix, Assistant Commissioning Editor Professor Joseph DeSimone attended Ursinus College (PA, USA) where he received his Bachelor of Science Degree in Chemistry. He completed his PhD in Chemistry in 1990 at Virginia Polytechnic Institute and State University (VA, USA). Professor DeSimone moved to the University of North Carolina at Chapel Hill (UNC-CH; NC, USA) where he was Assistant Professor of Chemistry until 1994. He was appointed Mary Ann Smith Professor of Chemistry at UNC-CH and Professor of Chemical Engineering at North Carolina State University (NC, USA) in 1995 and subsequently became William R Kenan Jr Distinguished Professor of Chemistry at UNC-CH in 1999. He is currently the Chancellor’s Eminent Professor of Chemistry at UNC-CH and the William R. Kenan Jr Distinguished Professor of Chemical Engineering at NC State. In 2004, Professor DeSimone founded Liquidia Technologies (NC, USA) which received the first ever equity investment by the Bill and Melinda Gates Foundation in a for-profit biotechnology company. He has received over 50 awards and accolades throughout his career, including the 2008 Lemelson-MIT Prize. Professor DeSimone has authored over 290 papers, as well as issuing 130 patents.
Effects of Suvorexant, an Orexin Receptor Antagonist, on Sleep Parameters as Measured by Polysomnography in Healthy Men (2013)

In healthy young men without sleep disorders, suvorexant promoted sleep with some evidence of residual effects at the highest doses.
Heteroleptic Ir(III)N<sub>6</sub> Complexes with Long-Lived Triplet Excited States and in Vitro Photobiological Activities (2019)

A series of cationic heteroleptic iridium(III) complexes bearing tris-diimine ligands [Ir(phen)<sub>2</sub>(R-phen)]<sup>3+</sup> (R-phen = phenanthroline (1), 3,8-diphenylphenanthroline (2), 3,8-dipyrenylphenanthroline (3), 3-phenylphenanthroline (4), 3-pyrenylphenanthroline (5), and 3,8-diphenylethynylphenanthroline (6)) were synthesized and characterized. These complexes possessed phen ligand-localized <sup>1</sup>π,π* transitions below 300 nm, and charge transfer (<sup>1</sup>CT) and/or <sup>1</sup>π,π* transitions between 300 and 520 nm. In 1, 2, 4, and 6, the low-energy bands were mixed <sup>1</sup>CT/<sup>1</sup>π,π*. However, the increased π-donating ability of the pyrenyl substituent(s) in 3 and 5 split the low-energy bands into a pyrene-based <sup>1</sup>π,π* transition at 300-380 nm and an intraligand charge transfer (<sup>1</sup>ILCT) transition at 380-520 nm. All complexes were emissive at room temperature in CH<sub>3</sub>CN, but the parentage of the emitting state varied depending on the R substituent(s). Complex 1 exhibited predominantly phen ligand-localized <sup>3</sup>π,π* emission mixed with metal-to-ligand charge transfer (<sup>3</sup>MLCT) character, whereas the emission of 2, 4, and 6 was predominantly from the excited-state with <sup>3</sup>π,π*/<sup>3</sup>ILCT/<sup>3</sup>MLCT character. The emission from 3 and 5 was dominated by pyrene-based <sup>3</sup>π,π* states mixed with <sup>3</sup>ILCT character. The different natures of the lowest triplet excited states were also reflected by the different spectral features and lifetimes of the triplet transient absorption of these complexes. Complexes 3 and 5 had singlet oxygen quantum yields as high as 81 and 72%, respectively. Both gave submicromolar phototoxicities toward cancer cells (SK-MEL-28 human melanoma) and bacteria ( S. aureus and S. mutans) with visible-light activation (and marginal to no photobiological activity with red light). Their visible-light phototherapeutic indices (PIs) toward SK-MEL-28 cells were 248 for 3 and >435 for 5; PIs were lower in bacteria (≤62) because of their inherent antimicrobial activities. Both complexes were shown to produce substantial amounts of intracellular reactive oxygen species (ROS), which may account for their photobiological activities.
ReSense (2013)

To utilize the full potential of modern chip multiprocessors and obtain scalable performance improvements, it is critical to mitigate resource contention created by multithreaded workloads. In this article, we describe ReSense, the first runtime system that uses application characteristics to dynamically map multithreaded applications from dynamic workloads—workloads where multithreaded applications arrive, execute, and terminate continuously in unpredictable ways. ReSense mitigates contention for the shared resources in the memory hierarchy by applying a novel thread-mapping algorithm that dynamically adjusts the mapping of threads from dynamic workloads using a precalculated sensitivity score. The sensitivity score quantifies an application's sensitivity to sharing a particular memory resource and is calculated by an efficient characterization process that involves running the multithreaded application by itself on the target platform. To measure ReSense's effectiveness, sensitivity scores were determined for 21 benchmarks from PARSEC-2.1 and NPB-OMP-3.3 for the shared resources in the memory hierarchy on four different platforms. Using three different-sized dynamic workloads composed of randomly selected two, four, and eight corunning benchmarks with randomly selected start times, ReSense was able to improve the average response time of the three workloads by up to 27.03%, 20.89%, and 29.34% and throughput by up to 19.97%, 46.56%, and 29.86%, respectively, over the native OS on real hardware. By estimating and comparing ReSense's effectiveness with the optimal thread mapping for two different workloads, we found that the maximum average difference with the experimentally determined optimal performance was 1.49% for average response time and 2.08% for throughput.
Bactericidal Activity of Aqueous Acrylic Paint Dispersion for Wooden Substrates Based on TiO2 Nanoparticles Activated by Fluorescent Light (2013)

The photocatalytic effect of TiO<sub>2</sub> has great potential for the disinfection of surfaces. Most studies reported in the literature use UV activation of TiO₂, while visible light has been used only in a few applications. In these studies, high concentrations of TiO₂, which can compromise surface properties, have been used. In this work, we have developed an acrylic-water paint dispersion containing low TiO₂ content (2 vol %) for the inactivation of microorganisms involved in hospital-acquired infections. The nanoparticles and the coating have been characterized using spectroscopic techniques and transmission electron microscopy, showing their homogenous dispersion in the acrylic urethane coating. A common fluorescent light source was used to activate the photocatalytic activity of TiO₂. The paint dispersion showed antimicrobial activity against <i>Escherichia coli</i>, <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. The coating containing the TiO₂ nanoparticles maintained good UV stability, strong adhesion to the substrate and high hardness. Therefore, the approach used is feasible for paint formulation aimed at disinfection of healthcare surfaces.
A<sup>3</sup>‐Coupling Reaction and [Ag(IPr)<sub>2</sub>]PF<sub>6</sub>: A Successful Couple (2017)

The recently described homoleptic cationic [Ag(IPr) 2 ]PF 6 [IPr = 1,3‐bis(2,6‐diisopropylphenyl)imidazolylidene] complex proved to be a versatile and highly efficient catalyst for the production of propargylamines by using the A 3 ‐coupling reaction. The reaction conditions were equally applicable to aliphatic and aromatic aldehydes and alkynes, including highly hindered aromatic aldehydes. Propargylamines were prepared in short reaction times with low catalyst loadings by using MeOH as a low‐toxicity solvent. In addition, the catalyst was stable enough to support continuous‐flow conditions, which showed that the reaction conditions are scalable.
Energy‐efficient static sparse‐tree adder based on MUX‐less bypassing architecture (2014)

An energy‐efficient 64 bit static sparse‐tree adder using a multiplexer (MUX)‐less bypassing scheme is proposed for mobile central processing units. Conventionally, bypassing schemes have been used to eliminate unnecessary switching of circuits but have incorporated a large delay overhead due to their output MUX, which reduces the energy efficiency of circuits in terms of power‐delay product (PDP). A novel static sparse‐tree adder is presented based on a proposed MUX‐less bypassing scheme to reduce the delay associated with the conventional bypassing scheme, thereby improving the energy efficiency, i.e. the PDP. Simulation results show a 30% reduction in PDP compared to the conventional bypassing adder and a 13% reduction from the state‐of‐the‐art technique.
Expectations of optical network traffic gain afforded by bit rate adaptive transmission (2010)

We propose and evaluate a metric for the value proposition of bit rate adaptive transmission in the form of the quasi-static multiplicative increase in network traffic that could be supported by an optical network without increasing the number of wavelength channels or spectral bandwidth. Under the assumption of idealized bit rate adaptive transmission, we assess the increase in network traffic throughput, or traffic gain, using the network global expectation model methodology and recent results and observations for the capacity limits of optical fiber transmission and the distance-dependence of capacity deployments. Depending upon the details of the optical transmission system technology, network topology, and traffic-influenced capacity profile, we estimate ideal potential network mean traffic gains in the range of 1.5X to 4X. é 2010 Alcatel-Lucent.
Deep sequencing analysis of M184V/I mutation at the switch and at the time of virological failure of boosted protease inhibitor plus lamivudine or boosted protease inhibitor maintenance strategy (substudy of the ANRS-MOBIDIP trial) (2021)

Using UDS evidenced that archiving of M184V in HIV-DNA is heterogeneous despite past historical M184V in 96% of cases. The antiviral efficacy of lamivudine-based dual therapy regimens is mainly due to the residual lamivudine activity.
Corrections to “A Silicon-Polymer Hybrid Modulator—Design, Simulation, and Proof of Principle” [Dec 13 4067-4072] (2015)

In the article, “A Silicon-polymer hybrid modulator—Design, simulation and proof of principle” (Himmelhuber, R., ibid., vol. 31, no. 24, pp. 4067–4072, Dec. 2013], an error was found in the code used for calculating the line capacitance of a the CPS electrode design. Corrections are presented here.
Multi-Regional Nuclear Energy Deployment Scenarios for a Sustainable Energy Future (2009)

While the potential role of nuclear energy to serve future energy needs is increasingly recognized, the worldwide deployment of nuclear energy will need to address various challenges to secure a sustainable nuclear energy future. Regional or local energy markets pose various requirements on the kind of nuclear power plants to be deployed, e.g. unit size of plants as well as serving various energy product markets, whereas natural resources and environmental sustainability criteria need to be achieved via the global nuclear fuel cycle. One challenge for nuclear energy deployment worldwide will be to find the necessary synergies between this local economic competitiveness for nuclear power plants and the global sustainability via the nuclear fuel cycle with due consideration for nonproliferation and safety throughout the whole nuclear energy system.Various studies have investigated such worldwide nuclear energy deployment scenarios indicating that such scenarios will need to include the deployment of advanced technologies (e.g., Generation-IV systems) within the current nuclear developed countries and the deployment of an international framework where the transfer or trade of fissile materials can be securely organized benefitting all world-regions needing nuclear energy.This paper discusses the multi-regional nuclear energy deployment scenario analysis aimed at investigating the synergy between local competitiveness and global sustainability for nuclear energy. By use of the DANESS model, various nuclear energy deployment scenarios for multiple world regions were investigated utilizing the projected energy demand for each region as reported by international authoritative studies. Three international nuclear energy policy strategies were considered. These strategies are not representative of a specific policy that is promoted by a country or an organization, but rather a set of hypothetical strategies that serves the discussion in this area. The considered scenarios are, as follows:- No trade of fissile material between the regions, i.e. each region has a rather independent nuclear energy deployment with only fuel cycle services bought on the international or, in most cases, domestic market;- Limited trade of fissile material between the regions consisting of an international fuel bank concept where countries are assured of nuclear fuel delivery without needing to deploy a domestic nuclear fuel cycle capability. Though, such strategy does not directly influence the decision on nuclear power plant investment as such;- An international nuclear energy service strategy based on an inter-governmental 'Sustainable Nuclear Energy framework' where international trade of fissile materials is inherently part of secured service agreements for nuclear power plants which become fueled via such international fuel trade framework.