gebhart/patrepeval huggingface dataset:
Immune response to a recombinant capsid protein of striped jack nervous necrosis virus (SJNNV) in turbot Scophthalmus maximus and Atlantic halibut Hippoglossus hippoglossus, and evaluation of a vaccine against SJNNV (2001)

Immunisation by intraperitoneal injection of an oil-emulgated recombinant partial capsid protein (rT2) from striped jack nervous necrosis virus (SJNNV) was performed on adult turbot Scophthalmus maximus and Atlantic halibut Hippoglossus hippoglossus. A specific humoral immune response was recorded in both species, and the levels of rT2-specific antibodies increased markedly in all groups during the 20 wk experiment. A challenge model for SJNNV was established by intramuscular injection of juvenile turbot. The turbot developed viral encephalopathy and retinopathy (VER), also known as viral nervous necrosis (VNN), with cumulative mortality in the range of 25 to 66%, after intramuscular inoculation with SJNNV propagated in the striped snake head cell line (SSN-1). Although neither clinical signs nor mortality were registered, SJNNV was neuroinvasive after bath exposure. The infection after both modes of challenge was verified by means of immunohistochemistry and RT-PCR, and SJNNV was reisolated in cell culture. The results indicate that SJNNV may have entered the central nervous system (CNS) by axonal transport through motor nerves after intramuscular inoculation. A vaccine efficacy test was performed on juvenile turbot, employing oil emulsified rT2 as a test vaccine and intramuscular inoculation of SJNNV. Significant protection was observed when the challenge was performed 10 wk post-vaccination.
26.4: Light‐Pipe Based Projection Engine Using Dual Paraboloid Reflector System and Polarization‐Recovery System for Projection Display (2004)

Abstract Projection engines consist of an illumination section, a color system, and a projection section and are mostly based on discrete optical components such as color filters, mirrors, relay lenses, prisms, etc. These components are usually bulky, costly, and require accurate mounting. In this paper, a totally light‐pipe based projection engine is described. It consists of an etendue‐efficient illumination system using the dual paraboloid reflector system with a lensed tapered light pipe and a light pipe based polarization recovery system as the illumination section. The color system is also light pipe based with prisms, beam splitters, and light pipes. The outputs of the color system are then directed into the corresponding HTPS imager chips. The outputs from the imager chips are then recombined by an X‐cube and projected onto the screen. This light‐pipe based engine uses low cost optical components and take up much less space than the traditional projection engine.
Fimbrolide-Coated Antimicrobial Lenses: Their In Vitro and In Vivo Effects (2008)

Fimbrolide-coated lenses show promise as an antibacterial and anti-acanthamoebal coating on contact lenses and appear to be safe when worn on the eye in an animal model.
Aphasia As a Complication Of CD19-Targeted Chimeric Antigen Receptor Immunotherapy (S52.006) (2014)

OBJECTIVE: To describe the specific complication of motor aphasia seen in a small minority of patients treated with CD19-targeted CAR therapy. BACKGROUND: CD19-targeted, genetically-modified autologous T-cell infusions are increasingly used to treat hematologic malignancies. Complications of immunotherapy are known to include cytokine storm with hypotension and encephalopathy. Focal neurological deficits have not been reported to be part of this syndrome despite successful treatment with CD19 CAR in multiple centers. DESIGN/METHODS: Three patients are described with regards to the specific complication of motor aphasia; other less focal neurological outcomes will be described elsewhere. Allen Brain Atlas was searched for CD19-probe expression in donor brains. RESULTS: Three patients out of 21 treated with CD19-targeted CAR developed motor aphasia 4-5 days after receiving CD19 CAR cells, following chemotherapy pre-treatment, progressing in two patients to generalized encephalopathy. One patient progressed to global aphasia and mild right face and arm weakness; one patient progressed to hyperreflexia and generalized myoclonus before becoming obtunded; one patient also had hemifacial spasm and progressed to encephalopathy. In all three patients aphasia and other neurological symptoms resolved over days and no correlative changes were seen on MRI or EEG. Data was available for expression of 2 CD19 probes in 6 donor human brains in the Allen Brain Atlas. Of these, one brain showed a higher expression of CD19 in the left inferior frontal gyrus. CONCLUSIONS: CD19-targeted CAR therapy can lead to a number of neurological complications, including a motor aphasia in some. CD19 may be expressed in a subset of neurons but is clearly variable between individual subjects, as evidenced by probe data in the Brain Atlas. Preferential expression in the language areas in some patients, for CD19 or related cytokines or other components of the CAR construct, may explain why reversible motor aphasia may complicate CD19 CAR immunotherapy in a small minority of patients. Study Supported by: This research was supported by the NIH Intramural Program.
Toward Inclusivity in Preclinical Drug Development: A Proposition to Start with Intestinal Organoids (2023)

Representation of humans from diverse backgrounds in the drug development process is key to advancing health equity, and while clinical trial design has recently made strides toward greater inclusivity, preclinical drug development has struggled to make those same gains. One barrier to inclusion is the current lack of robust and established in vitro model systems that simultaneously capture the complexity of human tissues while representing patient diversity. Here, the use of primary human intestinal organoids as a mechanism to advance inclusive preclinical research is proposed. This in vitro model system not only recapitulates tissue functions and disease states, but also retains the genetic identity and epigenetic signatures of the donors from which they are derived. Thus, intestinal organoids are an ideal in vitro prototype for capturing human diversity. In this perspective, the authors call for an industry-wide effort to leverage intestinal organoids as a starting point to actively and intentionally incorporate diversity into preclinical drug programs.
ChemInform Abstract: Stereospecific and Regiospecific Ring Opening of Glycidol with Primary and Secondary Alcohols Mediated by Diisobutylaluminum Hydride. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Arterial hypoxia does not affect subchondral pressure and regional blood flow. (1987)

The influence of arterial hypoxia on bone marrow pressure, regional blood flow and oxygen and carbon dioxide tensions was investigated by simultaneous and continuous measurements in the femoral condyles of 8 rabbits. Arterial hypoxia was obtained by hypoventilation. The subchondral gas tensions and regional blood flow were measured by a previously described technique based on mass spectrometry. Arterial hypoxia caused a significant decrease in subchondral oxygen tension and an increase in subchondral carbon dioxide tension. There was no significant change in bone marrow pressure and regional blood flow.
Roll Control of Low-Aspect-Ratio Wings Using Articulated Winglet Control Surfaces (2019)

The use of tip mounted winglets with independently variable cant angles was investigated as a means of roll control on wings with an aspect ratio of one. Wind-tunnel testing was performed in which a six-axis force balance was used to measure the total aerodynamic load on wings with winglet control surfaces. Stereoscopic digital particle image velocimetry of the near-wake plane was used to show how the topology of the tip vortices changed with winglet deflection. Shifts in the location of the right tip vortex core are considered to be responsible for roll moment generation because they indicate changes in the symmetry of suction-side flow structures. All winglet deflections were observed to shift the right tip vortex core inboard, and thereby shorten the effective span of the wing. The effect of a winglet deflection may be approximated as a change in the wing aspect ratio and a lateral shift in the wing aerodynamic center. Prandtl’s lifting line theory provides a closed-form estimate for the reduction in lift caused by a winglet deflection. A geometrical argument was made to account for the induced roll moment. The right tip vortex core also shifts vertically, following the deflected wing tip. Vertical shifts in the right tip vortex result in an angle between the wing span line and a line connecting the two tip vortices. A positive angle is defined as the right tip vortex higher over the wing than the left, and it is accompanied by a positive roll moment. While in sideslip, the wing with no winglet deflection experiences a considerable roll moment as a result of a vertical and lateral shift in the two tip vortices. The articulated winglets are observed to partially mitigate these effects when the upstream winglet is actuated, and thus show promise as a direct means of disturbance rejection.
EXPRESSION PROFILING OF HUMAN KIDNEY BIOPSIES FROM LIVING AND DECEASED DONORS REVEALS CANDIDATE SIGNALING PATHWAYS (2008)

Naesens, M1; Li, L1; Ying, L H1; Sansanwal, P1; Sigdel, T1; Kambham, N1; Lerut, E2; Salvatierra, O1; Butte, A1; Sarwal, M1 Author Information
Bioactive peptide functionalized superparamagnetic iron oxide nanoparticles (SPIONs) for targeted imaging with MRI (2015)

Magnetic resonance imaging (MRI) is a non-invasive imaging technique for both clinical and life sciences studies to diagnose various diseases. In addition to its high spatial resolution, MRI utilizes non-ionizing radiation and is capable of gathering three-dimensional tomographic images. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</sup> Since the abnormal tissue and normal tissue may have different intrinsic relaxation times depending on the physiological environment, specific contrast may be observed at a late stage of the disease. <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> In order to enhance the diagnostic use of MRI and detect diseases at an earlier stage, several types of contrast agents (CAs) have been designed which have the ability of shortening T <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1</inf> or T <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> relaxation times.
Tibio-Femoral Contact Force Distribution is Not the Only Factor Governing Pivot Location after Total Knee Arthroplasty (2019)

Total knee arthroplasty aims to mimic the natural knee kinematics by optimizing implant geometry, but it is not clear how loading relates to tibio-femoral anterior-posterior translation or internal-external pivoting. We hypothesised that the point of pivot in the transverse plane is governed by the location of the highest axial force. Tibio-femoral loading was measured using an instrumented tibial component in six total knee arthroplasty patients (aged 65-80y, 5-7y post-op) during 5-6 squat repetitions, while knee kinematics were captured using a mobile video-fluoroscope. In the range of congruent tibio-femoral contact the medial femoral condyle remained approximately static while the lateral condyle translated posteriorly by 4.1 mm (median). Beyond the congruent range, the medial and lateral condyle motions both abruptly changed to anterior sliding by 4.6 mm, and 2.6 mm respectively. On average, both the axial loading and pivot position were more medial near extension, and transferred to the lateral side in flexion. However, no consistent relationship between pivoting and load distribution was found across all patients throughout flexion, with R<sup>2</sup> values ranging from 0.00 to 0.65. Tibio-femoral kinematics is not related to the load distribution alone: medial loading of the knee does not necessarily imply a medial pivot location.
UK Growth: A New Chapter (2017)

The UK Economy is at a critical juncture. Leaving the EU creates economic challenges that necessitate widespread policy change. But this also generates an opportunity to tackle some of the long-standing challenges which have resulted in the UK's productivity lagging behind our major competitors. Decisions made in the next year will have a lasting impact on the UK's economic trajectory for years to come. If the government gets these decisions right, the economy will be more productive, more equitable and more environmentally sustainable. The LSE Growth Commission belongs to a longstanding tradition of engagement between research, business and policy-making which has been the hallmark of the LSE since its foundation. The report draws on evidence and analytical arguments to make a range of concrete policy recommendations affecting labour markets, industrial strategy, trade, immigration and finance. Together they form a blueprint for growth which should command support across the political spectrum.
New results in signal processing and compression of polygon meshes (2003)

Polygon meshes, which are used in most graphics applications, require considerable amounts of storage, even when they only approximate precise shapes with limited accuracy. To support Internet access to 3D models of complex virtual environments or assemblies for electronic shopping, collaborative CAD, multi-player video games, and scientific visualization, representations of 3D shapes must be compressed by several orders of magnitude. Furthermore, several closely related methods have been proposed in recent years to smooth, de-noise, edit, compress, transmit, and animate very large polygon meshes, based on topological and combinatorial methods, signal processing techniques, constrained energy minimization, and the solution of diffusion differential equations. This is an overview of some of my recent results in this area: linear anisotropic mesh filtering, bi-level isosurface compression, space-optimized texture maps, and volume warping for adaptive isosurface extraction.
Anchored p90 Ribosomal S6 Kinase 3 Is Required for Cardiac Myocyte Hypertrophy (2012)

Taken together, these data demonstrate that anchored RSK3 transduces signals that modulate pathologic myocyte growth. Targeting of signaling complexes that contain select kinase isoforms should provide an approach for the specific inhibition of cardiac myocyte hypertrophy and for the development of novel strategies for the prevention and treatment of heart failure.
Anomalous Temperature Dependent Transport through Single Colloidal Nanorods Strongly Coupled to Metallic Leads (2009)

We report wiring of individual colloidal nanorods (NRs), 30-60 nm long by 3.5-5 nm diameter. Strong electrical coupling is achieved by electron beam induced deposition (EBID) of metallic lines targeting NR tips with nanometric precision. At T = 4 K many devices exhibit smooth I(V) curves with no sharp onset features, which remarkably fit a Fowler-Nordheim tunneling model. All devices exhibit an anomalous exponential temperature dependence of the form I approximately exp(T/T(0)). This irregular behavior cannot be explained by any hopping or activation model and is interpreted by accounting for the lowering of the NR conduction band due to lattice dilation and phonon coupling.
Supplementary Methods from Characterization of MK-4166, a Clinical Agonistic Antibody That Targets Human GITR and Inhibits the Generation and Suppressive Effects of T Regulatory Cells (2023)

&lt;p&gt;This file contains supplementary methods that describe the antibodies used, the generation and characterization of MK-4166, various cell-based assays, and the evaluation of toxicity in cynomolgus monkeys.&lt;/p&gt;
Spectroscopy of the transition state (theory). II. Absorption by H‡3 in H+H2→H‡3→H2+H (1984)

Absorption spectra of transition state configurations in the reaction H+H2→H‡3 →H2+H have been computed. The density of H‡3 in configuration space was obtained from a classical trajectory study of collinear reaction on the Siegbahn, Liu, Truhlar, and Horowitz (SLTH) ab initio potential energy surface (PES). Vertical transitions were assumed to an upper PES H*3 modeled on limited ab initio data; four different model PES for H*3 were examined. The effects of varying reagent collision energy, varying reagent vibrational excitation, varying isotopic mass, and varying optical transition moment were explored. Transition state spectra were also computed for thermal distributions of H+H2, at 300 and 1000 K. The transition state spectra obtained constituted a wing extending as far as 40 000 cm−1 to the ‘‘red’’ of the Lyman-α transition. As illustrated here, the wing exhibited features that reflected the dynamics of reaction on the SLTH PES.
Interaction molecular QTL mapping discovers cellular and environmental modifiers of genetic regulatory effects (2023)

Bulk tissue molecular quantitative trait loci (QTLs) have been the starting point for interpreting disease-associated variants, while context-specific QTLs show particular relevance for disease. Here, we present the results of mapping interaction QTLs (iQTLs) for cell type, age, and other phenotypic variables in multi-omic, longitudinal data from blood of individuals of diverse ancestries. By modeling the interaction between genotype and estimated cell type proportions, we demonstrate that cell type iQTLs could be considered as proxies for cell type-specific QTL effects. The interpretation of age iQTLs, however, warrants caution as the moderation effect of age on the genotype and molecular phenotype association may be mediated by changes in cell type composition. Finally, we show that cell type iQTLs contribute to cell type-specific enrichment of diseases that, in combination with additional functional data, may guide future functional studies. Overall, this study highlights iQTLs to gain insights into the context-specificity of regulatory effects.
ChemInform Abstract: A Thermal Bicyclization: Synthesis of Substituted 2,3,5,6‐Tetrahydro‐6‐oxo‐1H‐pyrrolizines. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Index mismatch for diffuse photon density waves at both flat and rough diffuse–diffuse interfaces (1999)

By means of a surface-integral formalism we derive the integral equations for diffuse photon density waves with boundary conditions corresponding to a diffuse–diffuse interface with index mismatch and solve them numerically without any approximation. These numerical results are verified with Monte Carlo simulations for the planar interface case. Since the application of the boundary condition to index-mismatched media is difficult, an approximation that yields very accurate values is found. This approximation can be easily introduced into analytical models, and a study of its limit of validity is shown. We demonstrate with numerical results that the multiple-scattering contribution that is due to surface roughness can be neglected, even when index mismatch is present.
A New Design Method for High-Power High-Efficiency Switched-Capacitor DC–DC Converters (2008)

Switched-capacitor technology is widely used in low power dc-dc converter, especially in power management of the integrated circuit. These circuits have a limitation: high pulse currents will occur at the switching transients, which will reduce the efficiency and cause electromagnetic interference problems. This makes it difficult to use this technology in high-power-level conversion. This paper presents a new design method for dc-dc converter with switched-capacitorldquo technology. The new method can reduce the high pulse current which usually causes serious problem in traditional converters. Therefore, the power level of this new designed converter can be extended to 1 kW or even higher. A 1-kW 42/14-V switched-capacitor converter was designed for 42-V automotive system. The proposed converter has no requirement for magnetic components and can achieve a peak efficiency of 98% and 96 % at full load. The main circuit of the dc-dc converter is analyzed and its control scheme is presented in the paper. The experimental results verified the analysis and demonstrate the advantages.
Supplementary Table S1 from Global Expression Analysis of Cancer/Testis Genes in Uterine Cancers Reveals a High Incidence of &lt;i&gt;BORIS&lt;/i&gt; Expression (2023)

Supplementary Table S1 from Global Expression Analysis of Cancer/Testis Genes in Uterine Cancers Reveals a High Incidence of &lt;i&gt;BORIS&lt;/i&gt; Expression
Spinel Ferrite Co- Fe O Perpendicular Media on Exchange-Coupled Underlayers (2003)

Spinel ferrite Co- Fe O films have advantages of high coercivity, high stability without protective layer, and low noise performance for magnetic recording layer. Also, exchange-coupled Co-Zr-Nb/Co-Sm underlayers showed su- perior characteristics. The Co-Sm hard magnetic layer pinned the domains of Co-Zr-Nb soft magnetic layer effectively and decreased the noise coming from the soft magnetic layer. Com- bining the Co- Fe O recording layer and exchange-coupled Co-Zr-Nb/Co-Sm underlayers, the triple-layered perpendicular media showed abilities for ultrahigh-density perpendicular recording.
Immunosuppression and Monitoring of Rejection in Hand Transplantation (2013)

Advances in vascularized composite allotransplantation over the last decade have achieved significant milestones in basic science and translational research, as well as clinically with highly encouraging functional and immunologic outcomes. However, certain immunologic challenges remain. In particular, although tolerance has been induced to nearly all components of a hand allograft in experimental models, the skin component may still be subject to acute rejection episodes. Currently, conventional immunosuppressive protocols have been successful at preventing allograft loss; however, they have not prevented episodes of acute skin rejection. Furthermore, the profound side effect profile of the life-long, high-dose, multidrug immunosuppression regimen that is necessary to maintain a viable graft alters the risk to benefit ratio of this non-life-saving procedure. Therefore, there must be a concerted effort in the scientific community to develop novel protocols to either minimize immunosuppression or to induce tolerance to the allograft to promote the widespread application of this life-changing procedure.
2.5.2 Characterization and Application of Innovative Plasmonic Arrays (2012)

In order to increase the inherent weak but molecular specific Raman signature the exceptional optical properties of plasmonic nanostructures are used. This technique is termed as surface enhanced Raman spectroscopy (SERS) and combines the fingerprint specificity with potential single molecule sensitivity. However, the non-application of SERS in routine analytics is often linked with the low reproducibility of metallic nanostructures or metallic surfaces. Within this contribution, the fabrication of innovative plasmonic arrays with homogenous signal enhancement is introduced, which is an important contribution towards powerful SERS diagnostics. Here, the application of plasmonic arrays for DNA sensing is demonstrated.