gebhart/patrepeval huggingface dataset:
Kartagener's Syndrome: A Blinded, Controlled Study of Cilia Ultrastructure (1986)

We investigated respiratory mucosa cilia ultrastructure in patients homozygous for the gene for Kartagener's syndrome (KS) and patients apparently phenotypic for KS who had bronchiectasis and sinusitis but without situs inversus. Parents, as obligate carriers of the recessive KS gene, were also evaluated among other control groups. The four patients with KS had significantly fewer cilia outer dynein arms than normal subjects or parents of patients with KS. Two of five patients apparently phenotypic for KS demonstrated distinctive ultrastructural changes. No other subjects demonstrated explicit ultrastructural abnormalities. Internal control specimens showed that the number of outer dynein arms was consistent within a subject compared with variation between subjects. The outer dynein arm serves as a dependable ultrastructural marker. Carriers of KS do not demonstrate distinctive morphologic cilia abnormalities. Not every patient with chronic bronchiectasis and sinusitis demonstrates abnormal cilia ultrastructure.
Should computed tomography be the modality of choice for imaging Crohn's disease in children? The radiation risk perspective (2008)

Computed tomography (CT) and, more recently, CT enterography are excellent non-invasive tools for diagnosing Crohn’s disease, and for subsequent assessment of the disease, before and after therapy.1 In this light, and given the general availability and ease of use of CT machines, it is not surprising that CT is steadily replacing barium small-bowel follow-through as the radiological modality of choice for imaging Crohn’s disease.

There is, however, a potential downside, which is the radiation exposure produced by the CT scan. By their nature, CT scans result in radiation doses which are very much at the high end of those produced in diagnostic radiology, simply because a CT scan is effectively a large number of individual images that are electronically combined to produce a three-dimensional image. The effective dose involved in a CT scan is not large, but it is typically two to six times larger than that from barium small-bowel follow-through. Because of the typical long-term remission/relapse pattern of Crohn’s disease, together with the fact that is predominantly a disease of young people, Crohn’s disease patients are often imaged multiple times which, of course, correspondingly multiplies the radiation dose.

In this light, the report by Desmond et al 2 in this issue of the journal ( see page 1524 ) surveying trends in radiation exposure as a result of imaging …
Involvement of Platelet Activating Factor, Histamine and Serotonin in Acute Lethal Shock Induced by Candida albicans Water-Soluble Extracellular Polysaccharide Fraction (CAWS) in Mice (2007)

CAWS (Candida albicans water-soluble extracellular polysaccharide fraction) is a water-soluble extracellular mannoprotein-beta-glucan complex obtained from the culture supernatant following the culture of pathogenic Candida albicans in a completely synthetic medium. CAWS administered intraperitoneally induces vasculitis in mice, however, administered intravenously, it causes lethal shock. The acute lethal reaction to CAWS occurs within 1 h of intravenous administration, with the mice demonstrating anaphylactic shock-like symptoms including convulsion, diarrhea, and collapse. In this study, we analyzed the factors involved in this lethal effect. We examined physiologically active substances believed to be involved in anaphylactic shock, and found that the lethal effect of CAWS could be inhibited by blocking histamine, serotonin, and platelet activating factor (PAF) simultaneously, but by blocking only one. This finding strongly suggests that the acute lethal reaction to CAWS is a result of the simultaneous production of several physiologically active substances.
Studies on Morphology and Cytochemistry in Blood Cells of Ayu &lt;i&gt;Plecoglossus altivelis altivelis&lt;/i&gt; (2014)

Peripheral blood cells from ayu, Plecoglossus altivelis altivelis, were separated using a density gradient. Blood cells were then smeared using Shandon Cytospin and subjected to cytochemical staining. Blood cells were categorized based on morphological and cytochemical characteristics, and the density fractionation range and nucleus area/cell area ratio were observed. Lymphocytes are distinguished from neutrophils by their basophilic cytoplasm and Golgi-like field. The features of chromatin in thrombocytes are different from those of lymphocytes or neutrophils, but some small neutrophils have similar chromatin. Therefore, it is necessary to perform peroxidase staining to distinguish small neutrophils from thrombocytes. Basophils have large basophilic granules in cytoplasm. Based on density fractionation of blood cells, thrombocytes in the low-density area were separated from other blood cells. Identification of peripheral blood cells from ayu was possible with these staining methods. Monocytes/macrophages from spleen are specifically positive for esterase staining by α-naphthyl butyrate. As a result, thrombocytes, lymphocytes, neutrophils, basophils and monocytes/macrophages were identified in smears from peripheral blood or spleen tissue. In this paper, we confirmed that the peripheral blood corpuscles of ayu are able to be identified using the present staining methods.
A History of Cancer Research: Tumor Suppressor Genes (2020)

Tumor suppressor genes encode critical intracellular regulators, such as the retinoblastoma protein. They control processes including cell proliferation, cell survival, and responses to DNA damage and are frequently mutated in cancer. In this excerpt from his forthcoming book on the history of cancer research, Joe Lipsick looks back at the discovery of tumor suppressor genes, covering the early work on cell fusion by Henry Harris, Knudson's two-hit hypothesis, the genetic mapping studies that first identified the <i>RB</i> gene, and subsequent work on silencing.
EXPERIMENTAL STUDY FOR LAMINATED GLASS COMPOSED OF TEMPERED FIRE RESISTANCE GLASS EXPOSED TO STANDARD HEATING (2018)

Glass panes used for fire protection windows has not only flame barrier performance but also parts requiring scattering prevention performance, crime prevention performance and impact resistance in the event of breakage of the glass in some cases, laminated glass is often used . In general, Poly Vinyl Butyral is used as the interlayer. Furthermore, in combination with Low-E glass which has become very popular in recent years, combined double glazing glass which has a radiant heat reduction effect is also used. Fire protection window with tempered fire resistance glass has passed the certification test based on know-how of each manufacturing company so far and has been adopted after various fire certification, but there are not standards for ensuring clear fire prevent performance. Regarding heated glass on fire, the test data was accumulated on the single glass, the insulated glass unit (IGU) and the Low-E IGU based on the fire test, and the thermal stress generated in the glass can be explained by grasping the temperature difference were revealed. However, the temperature properties of the laminated glass composed of the tempered fire resistance glass to be heated are not systematically clarified, and it is necessary to obtain basic knowledge. Therefore, in this study, considering the behavior of laminated glass and laminated IGU made of tempered fire resistance glass which is heated based on the knowledge obtained in the previous report. The fire test condition is shown below. ·These fire tests were performed for Laminated glass and Laminated IGU. ·Tempered fire resistance glass was mainly located on fire side. ·Fire tests were performed along the ISO834 Heat Curve for each specimen. ·The temperature of the glass was measured by thermo couples with a data logger. ·Surface Compression, Edge Cover of Glass, and Emissivity of Low-E glass were treated as parameters for heat stress of glass, ΔT and breakage factor of the glass were checked by fire tests. ·Laminated glass by heating is affected by the interlayer, its behavior is confirmed. Findings are as follows. (1) As the temperature difference between the glass surface and the edge increases, high surface compression stress is required. (2) The temperature difference between the glass surface and the edge increases as edge cover becomes deep, and the glass tends to break more easily. (3) The interlayer of the laminated glass foams and a layer of air is formed, and the temperature of the surface of the unheated side glass tends to be low. When the interlayer foams by heating, a foamed part and an unfoamed part are generated. (4) If Low-E glass is used in laminated IGU, the emissivity of Low-E glass influences the foaming time of the interlayer and the failure behavior of the unheated side glass. (5) Transmission of radiant heat flux of laminated glass and laminated IGU on fire was estimated.
Antioxidant Properties of Buffalo-Milk Dairy Products: A β-Lg Peptide Released after Gastrointestinal Digestion of Buffalo Ricotta Cheese Reduces Oxidative Stress in Intestinal Epithelial Cells (2018)

Redox signaling regulates different gastrointestinal (G.I.) epithelium functions. At the intestinal level, the loss of redox homeostasis in intestinal epithelial cells (IECs) is responsible for the pathogenesis and development of a wide diversity of G.I. disorders. Thus, the manipulation of oxidative stress in IECs could represent an important pharmacological target for different diseases. In this study, peptides released from in vitro gastro intestinal digestion of different buffalo-milk commercial dairy products were identified and evaluated for their bioactive properties. In particular, six G.I. digests of dairy products were tested in a model of oxidative stress for IECs. Among them, buffalo ricotta cheese was the most active and the presence of an abundant β-lactoglobulin peptide (YVEELKPTPEGDL, f:60-72) was also revealed. The antioxidant potential of the identified peptide was also evaluated in a model of hydrogen peroxide (H2O2)-induced oxidative stress in the IEC-6 cell line. The peptide was able to reduce ROS release, while, on the other hand, it increased nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activation and the expression of antioxidant cytoprotective factors, such as heme oxygenase 1 (HO-1), NAD(P)H:quinone oxidoreductase 1 (NQO1), and superoxide dismutase (SOD). These results indicate that buffalo ricotta cheese-isolated peptide could have potential in the treatment of some gastrointestinal disorders.
For the love of paradox (2011)

The acute and chronic effects of certain drugs can often be opposite. For example, in congestive heart failure acute administration of β-adrenoceptor agonists results in beneficial improvement in symptoms of the disease, but their chronic use increases mortality. Conversely, certain β-adrenoceptor antagonists/inverse agonists (β-blockers) initially cause a detrimental response by decreasing cardiac contractility in congestive heart failure, whereas chronic treatment with the same β-blockers improves contractility and survival. Furthermore, this time-dependent reversal of outcomes occurs in nonpharmacological interventions, such as exercise, and can even be observed in the response of plants to pruning or other stressors, with the results being a different short-term versus long-term effect. Here, we review some of these phenomena with a special emphasis on the temporal dissociation of pharmacological effects. Although Francis Colpaert used this knowledge to lead a drug discovery project for an analgesic compound that initially produced hyperalgesia, we focused on examples outside the central nervous system.
MPEG-M: A Digital Media Ecosystem for Interoperable Applications (2013)

MPEG-M is a suite of ISO/IEC standards (ISO/IEC 23006) that has been developed under the auspices of Moving Picture Experts Group (MPEG). MPEG-M, also known as Multimedia Service Platform Technologies (MSPT), facilitates a collection of multimedia middleware APIs and elementary services as well as service aggregation so that service providers can offer users a plethora of innovative services by extending current IPTV technology toward the seamless integration of personal content creation and distribution, e-commerce, social networks and Internet distribution of digital media.
Slow light at high frequencies in an amplifying semiconductor waveguide (2006)

We demonstrate slow-down of a modulated light signal in a semiconductor waveguide. Concatenated amplifying and absorbing sections simultaneously achieve both amplification and a controllable time delay at 15 GHz.
Human longevity and common variations in the <i>LMNA</i> gene: a meta‐analysis (2012)

A mutation in the LMNA gene is responsible for the most dramatic form of premature aging, Hutchinson-Gilford progeria syndrome (HGPS). Several recent studies have suggested that protein products of this gene might have a role in normal physiological cellular senescence. To explore further LMNA's possible role in normal aging, we genotyped 16 SNPs over a span of 75.4 kb of the LMNA gene on a sample of long-lived individuals (LLI) (US Caucasians with age ≥ 95 years, N=873) and genetically matched younger controls (N=443). We tested all common nonredundant haplotypes (frequency ≥ 0.05) based on subgroups of these 16 SNPs for association with longevity. The most significant haplotype, based on four SNPs, remained significant after adjustment for multiple testing (OR=1.56, P=2.5 × 10(-5) , multiple-testing-adjusted P=0.0045). To attempt to replicate these results, we genotyped 3619 subjects from four independent samples of LLI and control subjects from (i) the New England Centenarian Study (NECS) (N=738), (ii) the Southern Italian Centenarian Study (SICS) (N=905), (iii) France (N=1103), and (iv) the Einstein Ashkenazi Longevity Study (N= 702). We replicated the association with the most significant haplotype from our initial analysis in the NECS sample (OR=1.60, P=0.0023), but not in the other three samples (P > 0.15). In a meta-analysis combining all five samples, the best haplotype remained significantly associated with longevity after adjustment for multiple testing in the initial and follow-up samples (OR=1.18, P=7.5 × 10(-4) , multiple-testing-adjusted P=0.037). These results suggest that LMNA variants may play a role in human lifespan.
The arthroscopic management of a cotyloid fossa lesion with concurrent hip dysplasia (2013)

Cumberland Infirmary, Newtown Road, Carlisle, Cumbria, United Kingdom CA2 7HY Financial Disclosure: The authors report no financial conflicts of interest. Correspondence to Richard Andrew Forrester, MBChB Hons, MRCS Ed, Cumberland Infirmary, Newtown Road, Carlisle, Cumbria, United Kingdom CA2 7HY Tel: +07801532371; fax: +07801532371; e-mail: [email protected]
Compensation of transmission channel effects in chaos synchronization (2011)

The synchronization of chaos is a well-known topic which attracted the attention of the scientific community in the last two decades. However, the robustness of the synchronous state has been not widely studied, especially considering real cases in which the effects introduced by the physical channel through which chaotic circuits interact, may deeply influence the quality of synchronization and even the onset of it. In this paper, the synchronization of two chaotic circuit coupled through a non-ideal channel is investigated. In particular, the effects of channels introducing a frequency-independent or frequency-dependent time-delay are investigated. Furthermore, two different design strategies to obtain a linear compensation block able to compensate the considered channel effects are presented and the recovery of the synchronous state is discussed.
&lt;title&gt;Electrically tunable NIR spectrometer&lt;/title&gt; (1997)

The packaging of a miniaturized NIR-spectrometer is demonstrated. The heart of this NIR-spectrometer is an electrically tunable silicon surface micromachined Fabry- Perot interferometer (FPI). For reliable operation, the FPI device has to be mounted so that thermo-mechanical stresses are not present in its active area. This can be realized basically by mounting FPI on a substrate that has a thermal expansion coefficient close to silicon, using elastic material for mounting or minimizing the joint area between FPI and substrate. The FPI provides the possibility for the manufacturing of a miniaturized single-axis NIR-spectrometer for large-volume applications.
The Active Phase of Nickel/Ordered Ce<sub>2</sub>Zr<sub>2</sub>O<sub><i>x</i></sub> Catalysts with a Discontinuity (<i>x</i>=7<b>–</b>8) in Methane Steam Reforming (2012)

Breaking news: A unique discontinuous property and an active phase of Ni/ordered Ce2Zr2Ox (x=7–8) solid-solution catalysts were observed during methane steam reforming. The catalytic performance of Ni/Ce2Zr2Ox strongly depended on the phase and oxygen content of the Ce2Zr2Ox support.
An integrated transcriptome and epigenome analysis identifies a novel candidate gene for pancreatic cancer (2013)

As aldehyde dehydrogenase (ALDH) activity is a key feature of cancer stem cells, our results indicate that a member of the ALDH superfamily, ALDH1A3, may be upregulated in pancreatic cancer, where it could mark pancreatic cancer stem cells.
Assessment of Existing Barrier Warrants for Roadside Slopes (2018)

The Roadside Design Guide acknowledges the shortcomings of its figure 5-1 for determining barrier need based on embankment geometry which dates to a 1967 study. This study confirmed what was observed as early as 1967 and again in 1987, when slopes are free of all other hazards, the addition of w-beam guardrail does not reduce the risk of observing an A+K crash. Recent research conducted on the probability of rollover has led to an improved understanding of slopes. This paper uses a risk-based approach to review the current RDG barrier considerations for embankments against the improved understanding of the probability of rollover and the subsequent severity of those crashes. Both the frequency and severity of crashes with and without 31-inch tall w-beam guardrails are estimated and the risk of observing an incapacitating or fatal injury crash calculated.
Disclosing false‐positive rates in the report: Useful or not? (2020)

In this issue, Poller and Schmitt provide an overview of false‐positive rates for cytologic interpretations of malignancy in different specimen types and ask an intriguing question: Should a malignant diagnosis include an acknowledgment of the risk of a false‐positive based on published literature?
Predicted transcription factor regulation of M1- and M2-associated gene expression in splenic macrophages from hamsters with VL. (2017)

&lt;p&gt;The set of differentially expressed genes in splenic macrophages was loaded into IPA software to predict the transcription factors likely to be activated. Shown is the overlapping network analysis of these transcription factors and the differentially expressed transcripts.&lt;/p&gt;
Optical phase imaging using a synthetic aperture phase retrieval technique (2014)

Optical phase imaging enables visualization of transparent samples, numerical refocusing, and other computational processing. Typically phase is measured quantitatively using interferometric techniques such as digital holography. Researchers have demonstrated image enhancement by synthetic aperture imaging based on digital holography. In this work we introduce a novel imaging technique that implements synthetic aperture imaging using phase retrieval, a non-interferometric technique. Unlike digital holography, phase retrieval obviates the need for a reference arm and provides a more compact, less expensive, and more stable experimental setup. We call this technique synthetic aperture phase retrieval.
Total elbow arthroplasty following complex fractures of the distal humerus: results in patients over 65 years of age. (2016)

According to the results observed, TEA can be considered as a valid treatment for complex fractures of the distal humerus in low-demanding patients older than 65 years of age, in which a stable fixation is difficult to obtain. Several variables may influence the final outcomes.
Supplementary Figure S5 from Real-world Studies Link NSAID Use to Improved Overall Lung Cancer Survival (2023)

&lt;p&gt;Supplemental Figure 5. The Kaplan-Meier analysis of overall lung cancer survival by NSAID type in (A) the MD Anderson Cancer Center database (MD Anderson cohort) and (B) the Georgetown cohort. Patients who used multiple NSAID types were excluded from this analysis.&lt;/p&gt;
Retargeting of lentivector integration by LEDGF/p75 chimera functionally rescues a cell culture model for X-linked CGD (2012)

status: Published
Water as a solvent for the Claisen rearrangement: practical implications for synthetic organic chemistry (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTWater as a solvent for the Claisen rearrangement: practical implications for synthetic organic chemistryPaul A. Grieco, Ellen B. Brandes, Stephen McCann, and Jerry D. ClarkCite this: J. Org. Chem. 1989, 54, 25, 5849–5851Publication Date (Print):December 1, 1989Publication History Published online1 May 2002Published inissue 1 December 1989https://doi.org/10.1021/jo00286a010RIGHTS & PERMISSIONSArticle Views1066Altmetric-Citations98LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (946 KB) Get e-Alertsclose Get e-Alerts
DNAmethylation profiling using Illumina BeadArray platform (2012)

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Three-Dimensionally Structured Betavoltaics (2018)

In this work we demonstrate three-dimensionally structured silicon diodes for use as a betavoltaic power source in conjunction with <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">147</sup> Pm. The concept of using a three-dimensionally structured semiconductor to increase the power density and efficiency of a betavoltaic device has existed for some time, even specifically for the combination of Si and Pm [1], [2], however this work is the first demonstration of infiltration of the radioisotope into the structured semiconductor; the previous works utilized either an e-beam gun or a sealed source to demonstrate power generation. MCNP simulations were carried out to determine the optimal feature sizes for maximizing power density and efficiency. We have fabricated three devices, which were filled with approximately 3, 7, and 28 mCi of PmCl <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> respectively. These devices produced an output current greater than what could be achieved in a coplanar device, demonstrating successful infiltration of the radioisotope.