gebhart/patrepeval huggingface dataset:
Laryngeal Cancer With Lung Metastases Showing Long-Term Complete Response and Delayed Immune-Related Adverse Event After Nivolumab Discontinuation (2021)

We report a case of laryngeal cancer with multiple lung metastases that maintained a complete response (CR) for 18 months after discontinuing nivolumab treatment, with colitis developing 5 months after drug discontinuation. A 65-year-old man was diagnosed with T3N2cM0 stage IVA right supraglottic squamous cell carcinoma that progressed after 1 course of TPF (cisplatin, docetaxel, and 5-fluorouracil) as induction chemotherapy. He underwent total laryngectomy, bilateral neck dissection, pharyngeal reconstruction with anterolateral thigh flap, and creation of a permanent tracheostoma; extranodal extension was detected in the right cervical lymph node metastasis, and the patient underwent adjuvant radiotherapy. Multiple lung metastases occurred during radiotherapy, and the patient was deemed platinum refractory; nivolumab treatment was thus initiated. The tumor proportion score for programmed death-ligand 1-evaluated via antibody testing of the laryngeal tumor-was <1. The patient received 240 mg/body nivolumab every 2 weeks; a computed tomography performed after course 16 of nivolumab treatment confirmed a CR. He exhibited grade 2 thyroid dysfunction, grade 1 interstitial pneumonia, and grade 2 colitis after 6, 7, and 14 months of receiving nivolumab, respectively; treatment was discontinued as despite maintaining a CR, interstitial pneumonia occurred twice. Colitis appeared 5 months after nivolumab discontinuation; nevertheless, a CR was maintained after 18 months.
[Association of PON2 gene polymorphisms in neonates with preterm]. (2002)

Branch of Institute for Biomedicine,Anhui Medical University,Anqing 246000,China Abstract:The objective is to investigate whether gene polymorphisms in the PON2 gene (PON2148 and PON2311) of neonates are associated with preterm. Using standard questionnaires,194 singleton live born mother-neonate pairs (include preterm cases and term controls) were investigated by the trained field workers with cross-sectional survey at the hospitals in Anqing,Anhui Province,China. Epidemiological and clinical data and blood samples were obtained from 194 mother-neonate pairs. Among neonates,PON2 Ala148Ala homozygote is significantly associated with preterm,compared with Gly148Gly homozygote / Ala148Gly heterozygote before and after adjustment confounders and the same was true for PON2 Ser311Ser homozygote. However,when PON2148 polymorphism and PON2311 polymorphism were considered jointly,no significant gene interaction between PON2148 polymorphism and PON2311 polymorphism in relation to preterm was observed. We draw a conclusion from this research that both PON2148 polymorphism and PON2311 polymorphism in neonates are significantly associated with preterm respectively. But the gene interactions between PON2148 polymorphism and PON2311 polymorphism in neonates are not significantly associated with preterm.
Intramolecular Electron Transfer through the 20-Position of a Chlorophyll <i>a</i> Derivative:  An Unexpectedly Efficient Conduit for Charge Transport (2006)

Suzuki cross-coupling reactions have afforded 20-phenyl-substituted Chlorophyll a derivatives (ZCPh) in good yields and significant quantities from readily available Chl a. A series of donor-acceptor dyads was synthesized in which naphthalene-1,8:4,5-bis(dicarboximide) or either of two perylene-3,4:9,10-bis(dicarboximide) electron acceptors is attached to the para position of the 20-phenyl group. Comparisons with the analogous dyads based on a zinc 5,10,15-tri(n-pentyl)-20-phenylporphyrin donor show that, for a given acceptor and solvent, the rates of photoinduced charge separation and recombination as well as the calculated electronic coupling matrix elements, V, for these reactions differ by less than a factor of 2. However, EPR and ENDOR spectroscopy corroborated by DFT calculations show that the highest occupied MO of ZCPh+* has little spin (charge) density at the 20-carbon atom, whereas Z3PnPh+* has significant spin (charge) density there, implying that V, and therefore the electron-transfer rates, should differ significantly for these two macrocyclic donors. DFT calculations on ZCPh+* and Z3PnPh+*, with two -0.5 charges located where the nearest carbonyl oxygen atoms of the acceptor would reside in the donor-acceptor dyads, show that the presence of the negative charges significantly shifts the charge density of both ZCPh+* and Z3PnPh+* from the macrocycle onto the phenyl rings. Thus, the presence of adjacent covalently linked radical anions at a fixed location relative to each of these radical cations results in nearly identical electronic coupling matrix elements for electron transfer and therefore very similar rates.
[Standardization of evaluation for target molecule in cancer therapy]. (2011)

The individualized-therapy for the gastrointestinal tract cancer is started by the emergence of molecular targeted-therapy. The patients' selection for treatment is now performed by evaluating the expression level of the targeted molecules and/or the gene mutation analysis using the pathological specimens. Pathologists should make diagnosis and select patients for the fittest molecular targeted therapy in colon cancer, stomach cancer and gastrointestinal stromal tumor(GIST). In the present paper, we focused and discussed the points of the evaluation of the targeted-molecule in pathological materials for selecting patients using the examples of HER2 test in gastric cancer and K-RAS muation in colon cancer.
Field and temperature dependence of TDDB of ultrathin gate oxide (1999)

The results of an investigation of time-dependent breakdown (TDDB) of intrinsic ultrathin gate oxide are presented for a wide range of oxide fields 4.6<E/sub ox/<10.4 MV/cm at elevated temperatures. It was found that TDDB of ultrathin oxide follows the E model down to 4.6 MV/cm. The data show that TDDB t/sub 50/ starts deviating from the 1/E model for fields below 7.2 MV/cm. The data also show that the TDDB activation energy for this type of gate oxide is linearly dependent on oxide field. In addition, we show that the field acceleration parameter /spl gamma/ decreases as temperature increases.
Electrochemical‐ <scp>AFM</scp> (2003)

Abstract The sections in this article are Introduction Principles of AFM Substrate Preparation AFM Investigation of the Electrified Solid–solution Interface Imaging Applications of Electrochemical AFM The Role of Ionic Adsorbates in Electrode Behavior Underpotential deposition Corrosion Studies Molecular Adsorbates on Electrode Surfaces Electrochemical Force Data Acquired Using the AFM Approach Curve Measurements Retract Curve Measurements Electrochemically Active AFM Probes Microfabricated Conducting AFM Probes Microwire Conducting AFM Probes Conclusion Acknowledgments
Activity of a Carbohydrate-Binding Module Therapy, Neumifil, against SARS-CoV-2 Disease in a Hamster Model of Infection (2022)

The rapid global spread of severe acute respiratory coronavirus 2 (SARS-CoV-2) has resulted in an urgent effort to find efficacious therapeutics. Broad-spectrum therapies which could be used for other respiratory pathogens confer advantages, as do those based on targeting host cells that are not prone to the development of resistance by the pathogen. We tested an intranasally delivered carbohydrate-binding module (CBM) therapy, termed Neumifil, which is based on a CBM that has previously been shown to offer protection against the influenza virus through the binding of sialic acid receptors. Using the recognised hamster model of SARS-CoV-2 infection, we demonstrate that Neumifil significantly reduces clinical disease severity and pathological changes in the nasal cavity. Furthermore, we demonstrate Neumifil binding to the human angiotensin-converting enzyme 2 (ACE2) receptor and spike protein of SARS-CoV-2. This is the first report describing the testing of this type of broad-spectrum antiviral therapy in vivo and provides evidence for the advancement of Neumifil in further preclinical and clinical studies.
Comparison between Discontinuous and Continuous Lactose Conversion Processes for the Production of Prebiotic Galacto-oligosaccharides Using β-Galactosidase from <i>Lactobacillus reuteri</i> (2007)

Galacto-oligosaccharide (GOS) formation from lactose in discontinuous and continuous modes of conversion was investigated using beta-galactosidase (beta-gal) from Lactobacillus reuteri. A continuous stirred tank reactor (CSTR) with an external crossflow membrane was set up, and continuous GOS production was analyzed and compared to the batchwise formed GOS product. Marked differences were detected for the two reactor setups. Above 65% lactose conversion, the GOS yield was lower for the CSTR due to a lower content of tri- and tetrasaccharides in the reaction mixture. In the CSTR, beta-gal from L. reuteri showed up to 2-fold higher specificity toward the formation of beta-(1-->6)-linked GOS, with beta-D-Galp-(1-->6)-D-Glc and beta-D-Galp-(1-->6)-D-Gal being the main GOS components formed under these conditions. This could be used to synthesize more defined GOS products.
A Low-Noise High-Frame-Rate 1-D Decoding Readout Architecture for Stacked Image Sensors (2014)

The continuously increasing array resolution of CMOS imagers poses a great challenge in combining high-frame-rate and low light detection in the same sensor. To cope with this, parallel readout architectures are needed. This paper proposes a readout architecture for 8K stacked image sensors, which uses a novel 1D decoding readout based on block-of-pixels and incremental-sigma-delta ADCs. The proposed 1D decoding system reduces the control lines of the pixels and allows a simpler decoding, an increased parallelism, and an improved robustness over process yield. The experimental results from a test chip implemented in a standard CIS technology show that at 10 μm pixel pitch, the proposed readout architecture can achieve a high-frame-rate of 730 frames/s and a low read noise of 1.4 e <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-</sup> . In a real stacked implementation, the frame rate can further increase to about 960 frames/s at 8K resolution, at the cost of a slight increase in thermal noise by 14 μV.
Fixed-point Based Hierarchical MPC Control Design For a Cryogenic Refrigerator (2017)

In this paper, a simple and general hierarchical control framework is proposed and validated through the interconnection of the Joule-Thompson and the Brayton cycle stages of a cryogenic refrigerator. The proposed framework enables to handle the case of destabilizing interconnections through state and/or control signals (which is the case of the cryogenic refrigerator example). Moreover, it offers the possibility to simply change the behavior of the overall system (depending on the context) by only changing the coordinator problem's parameters without changing the set of local controllers used by subsystems which is a common industrial requirement regarding industrial control architectures. Finally, the proposed scheme enables a smooth operator handover on a specific subsystem and/or actuator.
Bioreduction of hexavalent chromium by chromium resistant alkalophilic bacteria isolated from tannery effluent (2020)

Two chromium resistant alkalophilic bacterial strains (CRAB), namely Bacillus cohnii SR2 and Bacillus licheniformis SR3 were isolated and identified from tannery effluent. Bioreduction of chromium (VI) into chromium (III) by CRAB was investigated in the present study. Optimization of process parameters with respect to bioreduction percentage was studied by Response Surface Methodology (RSM) software, v12. Both the strains were found to achieve highest chromium (VI) bioreduction of 94 and 95% in 100 mg/L at the end of 25 h at pH 9.0. At an optimized concentration of 550 mg/L, a maximum bioreduction of 82 and 90% by SR2 and SR3 was noted within 25 h. In addition, both the strains showed tolerance to chromium until 1000 mg/L. Scale-up studies using Air lift bioreactor system by CRAB with real tannery effluent showed 100% bioreduction within 8 h. Therefore, this study signified the astonishing bioreduction capability of CRAB isolates that was quite evident in scale-up studies too.
Secure Multi-Party Computation with Identifiable Abort. (2015)

Protocols for secure multi-party computation (MPC) that resist a dishonest majority are susceptible to “denial of service ” attacks, allowing even a single malicious party to force the protocol to abort. In this work, we initiate a systematic study of the more robust notion of security with identifiable abort, which leverages the effect of an abort by forcing, upon abort, at least one malicious party to reveal its identity. We present the first information-theoretic MPC protocol which is secure with identifiable abort (in short ID-MPC) using a correlated randomness setup. This complements a negative result of Ishai et al. (TCC 2012) which rules out information-theoretic ID-MPC in the OT-hybrid model, thereby showing that pairwise correlated randomness is insufficient for information-theoretic ID-MPC. In the standard model (i.e., without a correlated randomness setup), we present the first computationally secure ID-MPC protocol making black-box use of a standard cryptographic primitive, namely an (adaptively secure) oblivious transfer (OT) protocol. This provides a more efficient alternative to existing ID-MPC protocols, such as the GMW protocol, that make
Binocular interactions in accommodation control: effects of anisometropic stimuli (1992)

In binocular viewing of real targets, the accommodative demand in the two eyes is not in general identical, yet the accommodation response in the two eyes is equal. In order to investigate how the accommodative signals from the two eyes are combined, this study has examined the effects of several forms of dynamic anisometropic stimulation on the accommodation response in both man and the rhesus monkey (Macaca mulatta). All experiments were performed in a computer-controlled haploscopic apparatus to allow independent control of the accommodative stimuli to the two eyes and of the vergence stimulus. The vergence stimulus was held constant while the accommodation demand was modulated independently in each eye. Accommodation was monitored continuously with a dynamic infrared optometer. Four anisometropic conditions were used. In two of these conditions, accommodation demand was varied sinusoidally with time in both eyes, but with phases differing by 90 degrees or 180 degrees between the two eyes. In the two remaining conditions, accommodation demand in one eye varied sinusoidally, while the accommodation demand was constant in the other. In all cases, the form of the target pattern was identified in the two eyes. The accommodation responses observed with these stimulus conditions were similar in both man and the monkey. When presented with conflicting stimuli in the two eyes, the accommodation response appeared to be best described as a compromise between the inputs to the two eyes; there were no indications of a purely random alternation of eye dominance of the form seen in binocular contour rivalry. When the accommodation demand was modulated in only one eye, there was a modulated accommodation response of similar phase to the control condition (i.e., both eyes modulated in phase) but with a much smaller gain (mean, 39% of control gain). When the accommodation demand was modulated in both eyes with a phase difference of 180 degrees, no significant modulation was observed in the accommodation response at the stimulation frequency. When the interocular phase difference was 90 degrees, a modulated response was observed that showed a mean phase lag 41 degrees more than that observed in the control condition (both eyes modulated in phase) and an appreciably smaller gain (mean, 55% of control gain). The extent to which the results can be described by a linear vector average of the uniocular inputs is considered.
Hormonal regulation of epidermal growth factor and insulinlike growth factor-I in adult male hypophysectomized rats treated with ethane dimethane sulphonate (1991)

There is increasing evidence implicating growth factors in the regulation of spermatogenesis and in-vitro studies have shown that epidermal growth factor (EGF) and insulin-like growth factor-I (IGF-I) interact with the gonadotrophins in regulating testicular function. In the present study, the effect of FSH, testosterone and GH treatment on serum IGF-I and intratesticular EGF and IGF-I concentrations in adult male hypophysectomized rats treated with ethane dimethane sulphonate (EDS) to destroy Leydig cells has been investigated. Hypophysectomy alone or followed by EDS treatment was associated with a significant increase in intratesticular EGF concentrations compared with normal controls (P less than 0.05). Treatment of hypophysectomized animals with a combination of GH, FSH and testosterone resulted in a return of intratesticular EGF concentrations to normal control levels. In a second group of animals treated with a 5 cm silicone elastomer implant of testosterone and FSH, intratesticular EGF concentrations were also not significantly different from those of normal controls. Following hypophysectomy alone or hypophysectomy and EDS treatment, a significant increase in circulating IGF-I concentrations occurred, which was only reversed following the administration of GH. In addition, increases in testicular IGF-I concentrations were evident in all treated animals compared with controls, an effect which was only partially reversed in animals treated with a combination of FSH and testosterone (1.5 or 5 cm implant). Similar results were obtained with a combination of GH and FSH or GH and testosterone, although GH alone had no effect on testicular IGF-I concentrations. A combination of GH, FSH and testosterone restored testicular IGF-I to concentrations not significantly different from controls.(ABSTRACT TRUNCATED AT 250 WORDS)
Evidence of compositional differences between the extracellular and intracellular DNA of a granular sludge biofilm (2011)

The findings further the idea that eDNA has a functional role in the biofilm state, which is an important conceptual information for industrial application of biofilms.
Whole Grains and Risk of Hepatocellular Carcinoma—Missing the Forest for the Trees?—In Reply (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Oncology HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Oncology journal
Altered Th1/Th2 balance associated with the immunosuppressive/protective effect of the H‐2A<sup>b</sup> allele on the response to allo‐4‐hydroxyphenylpyruvate dioxygenase (1995)

The H-2Ab allele exerts a dominant down-regulatory effect on the anti-allo-HPPD (4-hydroxyphenylpyruvate dioxygenase) antibody response, through a hitherto unknown mechanism. In the present study, the allo-variable peptide bound to responder H-2Ak molecules with higher affinity than to H-2Ab ones, arguing against the operation of an affinity hierarchy. Quantitative polymerase chain reaction revealed differences in cytokine mRNA expression between suppressed and high-responder mice. Lymph node cells of responder but not suppressed mice contained high levels of interleukin (IL)-4 mRNA as early as 11 h post-immunization and continued to do so for at least 8 days; this early burst was paralleled by a small burst in transforming growth factor (TGF)-beta mRNA level. Differences in IL-12 mRNA were not detected, although an early IL-12 effect could not be excluded. Interferon (IFN)-gamma appeared to contribute to the suppression at later time points. Early treatment of responder mice with anti-IL-4 monoclonal antibody (11B11) down-regulated the antibody response. The proliferative T cell response from hyperimmunized mice was reduced but still detectable in the presence of an H-2Ab allele. Thus, in the presence of this allele, the Th1 response is enhanced and that of Th2 cells suppressed, apparently as a result of the bias of H-2Ab-restricted T cells in favor of the Th1 subset.
Surface Micromachining in Optical Isolator with Semiconductor Guiding Layer for Enhancement of Magnetooptic Effect (2003)

A magnetooptic waveguide with a magnetic garnet/GaInAsP/air structure was effective in enhancing the magnetooptic effect. Surface micromachining was investigated for fabricating a magnetooptic waveguide in an optical isolator with a semiconductor guiding layer. As a preliminary experiment, a GaInAsP rib waveguide with an air cladding layer was fabricated by selective wet etching. The rib waveguide with a 1-mm-long air bridge was successfully obtained on the GaInAsP guiding layer. Light waves could be guided in the GaInAsP waveguide with the air bridge structure.
Development of low-coherence light sheet illumination microscope for fluorescence-free bioimaging (2011)

Light Sheet Illumination Microscopy (LSIM) is an imaging modality featuring the novel arrangement with the illumination axis perpendicular to the detection axis. In this technology a well defined light sheet is generated and aligned precisely to the focal plane of the microscope objective and thus only the thin in-focus layer of the sample is illuminated and imaged, thereby avoiding out-of-focus light. Besides the inherent optical sectioning function, other advantages include fast imaging speed, high longitudinal resolution and decreased light-induced damage. Though promising, this microscopy is currently restricted to imaging fluorescently labeled tissue; in inspection of intact tissue using scattered light, the acquired images suffer from intense speckles because of the severe coherence in the illumination. This work aims to build a microscope capable of achieving intrinsic images of the fluorescence-free sample with reduced or eliminated speckles, by developing a low coherence light sheet illumination. To diminish the spatial coherence, the sample is illuminated with tens of independent sub-beams (without inter-coherence) illuminating the FOV (Field Of View) of the microscope with diverse incident angles. The temporal coherence is dramatically reduced by employing a supercontinuum laser with a broad spectrum as the light source. The new microscopy significantly extends the functionality of Light Sheet Illumination Microscopy and will enable many new bioimaging applications.