gebhart/patrepeval huggingface dataset:
A Distributed Hash Table based Address Resolution Scheme for Large-Scale Ethernet Networks (2007)

Ethernet's plug-&-play feature is built on its use of flat (location independent) addresses and use of broadcasts to resolve unknown MAC addresses. While plug-&-play is one of Ethernet's most attractive features, it also affects its scalability. As the number of active MAC addresses in the network grows beyond the capacity of forwarding caches in bridges, the odds of "cache-misses," each triggering a broadcast, grow as well. The resulting increase in broadcast bandwidth consumption affects scalability. To address this problem, we propose a simple address resolution scheme based on an adaptation of distributed hash tables where a single query suffices in the steady state. The new scheme is implemented on advanced bridges maintaining backward compatibility with legacy bridges and eliminating reliance on broadcasts for address discovery. Comparisons with a legacy, broadcast-based scheme are carried out along several metrics that demonstrate the new scheme's robustness and ability to improve scalability.
Autoacetylation of the Ralstonia solanacearum Effector PopP2 Targets a Lysine Residue Essential for RRS1-R-Mediated Immunity in Arabidopsis (2010)

Type III effector proteins from bacterial pathogens manipulate components of host immunity to suppress defence responses and promote pathogen development. In plants, host proteins targeted by some effectors called avirulence proteins are surveyed by plant disease resistance proteins referred to as "guards". The Ralstonia solanacearum effector protein PopP2 triggers immunity in Arabidopsis following its perception by the RRS1-R resistance protein. Here, we show that PopP2 interacts with RRS1-R in the nucleus of living plant cells. PopP2 belongs to the YopJ-like family of cysteine proteases, which share a conserved catalytic triad that includes a highly conserved cysteine residue. The catalytic cysteine mutant PopP2-C321A is impaired in its avirulence activity although it is still able to interact with RRS1-R. In addition, PopP2 prevents proteasomal degradation of RRS1-R, independent of the presence of an integral PopP2 catalytic core. A liquid chromatography/tandem mass spectrometry analysis showed that PopP2 displays acetyl-transferase activity leading to its autoacetylation on a particular lysine residue, which is well conserved among all members of the YopJ family. These data suggest that this lysine residue may correspond to a key binding site for acetyl-coenzyme A required for protein activity. Indeed, mutation of this lysine in PopP2 abolishes RRS1-R-mediated immunity. In agreement with the guard hypothesis, our results favour the idea that activation of the plant immune response by RRS1-R depends not only on the physical interaction between the two proteins but also on its perception of PopP2 enzymatic activity.
Tumor-Associated Galectin-3 Modulates the Function of Tumor-Reactive T Cells (2008)

T cells play an important role in cancer immunosurveillance and tumor destruction. However, tumor cells alter immune responses by modulating immune cells through antigen stimulation and immunoregulatory cytokines. A better understanding of the interplay between tumor cells and T cells might provide new strategies to enhance antitumor immunity. Through an antigen-screening approach using colorectal tumor-reactive T cells, we identified an HLA-DR11-restricted T-cell epitope encoded by KIAA0040 as well as MHC-unrestricted human galectin-3 (Gal-3) expressed by tumor cells. Although the biological function of KIAA0040 remains to be determined, we found that Gal-3 functioned as an immune regulator for direct T-cell activation and function. T-cell activation induced by Gal-3 resulted in T-cell apoptosis. We showed that a high level of expression of Gal-3 promoted tumor growth in vitro and in vivo. Using a mouse tumor model, we showed that delivery of high doses of Gal-3 inhibited tumor-reactive T cells and promoted tumor growth in mice receiving tumor-reactive CD8(+) T cells. These findings suggest that Gal-3 may function as an immune regulator to inhibit T-cell immune responses and promote tumor growth, thus providing a new mechanism for tumor immune tolerance.
Investigation of temperature response of photopolymer material used for holographic sensor (2018)

Recently, functionalised photopolymer has emerged as a versatile recording material in the field of optical holography due to its novel characteristics and potential use in the development of holographic based sensors, and optical elements. This work describes the temperature response of a newly developed photopolymer, containing of a monomer N-isopropylacrylamide (NIPA) which under photopolymerisation forms a temperature sensitive polymer - Poly(N-isopropylacrylamide) (PNIPA). The photonic sensor was developed by holographic recording of volume phase transmission gratings in a self-processing NIPA-based polymer with a 532 nm laser beam. A 633 nm probe beam was used to monitor real time diffraction efficiency (DE) growth curve and the temperature dependent response of DE in the temperature range 22-50°C. It was observed that the DE increased with increasing temperature at 10°C min <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> and started to drop by reversing the temperature at 5°C min <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-1</sup> . It was also observed that the response depends on the rate of heating/cooling and the time spent at elevated temperature. The observed response to temperature could be used to design an indicator for packaging, showing that the content of the package has been exposed to a temperature that was above a predetermined temperature limit.
The antioxidative effect of ganhuangenin against lipid peroxidation (1999)

The antioxidative effect of ganhuangenin (GHG), isolated from Scutellaria baicalensis Georgi, was examined by measuring its ability to suppress the formation of phospatidylcholine hydroperoxide (PCOOH). The results show that a pretreatment with GHG effectively suppressed PCOOH formation, which was initiated by the peroxyl-generating oxidant, AAPH (2,2'-azobis-2-aminopropane hydrochloride). The protective action of GHG against the formation of the PCOOH was observed in liver, lung, and kidney. When compared with other known antioxidants, we found the antioxidative potency of GHG to be greater than that of alpha-tocopherol. Our data strongly indicate that GHG is a powerful antioxidant against lipid peroxidation and is, therefore, responsible for this prophylactic effect.
Efficient implementations of ultrasound color Doppler algorithms on VLIW architectures (2009)

DSP chips are gaining importance in ultrasound applications as the need for portability and low power grows. One of the more computationally demanding applications for ultrasound involves estimating blood flow characteristics using Doppler techniques. This ultrasound mode, called color Doppler ultrasound, is used to diagnose many conditions like blood clots, valve defects and blocked arteries. This work looks at mapping some typical color Doppler algorithms onto Texas Instruments' (TI's) high performance C64x+<sup>(TM)</sup> core. The algorithms include RF demodulation, wall filtering and flow power, velocity and turbulence estimation. This paper starts with a general technique for analyzing algorithm complexity in terms of CPU instruction cycles on VLIW architectures like the C64x+<sup>(TM)</sup>. It then applies this technique to Doppler processing algorithms, explains their mapping to the C64x+<sup>(TM)</sup> architecture and derives lower bounds for the computational complexity for these algorithm kernels. For each of these algorithms, these estimates are finally compared to actual implementations, and various implementation tradeoffs will be illustrated. Based on these implementations, it will be shown that these algorithms can run on TI's C64x+<sup>(TM)</sup> based DSPs using a fraction of the available processing power.
Condition monitoring of gas-turbine power units using the Derivative-free nonlinear Kalman Filter (2018)

A method is developed for diagnosing faults and cyberattacks in electric power generation units that consist of a gas-turuine and of a synchronous generator. By proving that such a power generation unit is differentially flat its transformation into an input-output linearized form becomes possible. Moreover, by applying the Derivative-free nonlinear Kalman Filter state estimation for the power unit is performed. The latter filtering method, consists of the Kalman Filters recursion on the linearized equivalent model of the power unit, as well as of an inverse trans- formation providing estimates of the initial nonlinear system. By suutracting the estimated outputs of the Kalman Filter from the measured outputs of the power unit the residuals sequence is generated. The residuals undergo statistical processing. It is shown that the sum of the squares of the residuals vectors, weighted by the inverse of the associated covariance matrix, forms a stochastic variable that follows the X <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> distribution. By exploiting the statistical properties of this distribution, confidence intervals are defined, which allow for detecting the power units malfunctioning. As long the aforementioned stochastic variable remains within the previous confidence intervals the normal functioning of the power unit is inferred. Otherwise, a fault or cyberattack is detected. It is also shown that by applying the statistical method into subspaces of the system's state-space model, fault or cyberattack isolation can be also performed.
Erratum to: Heterojunction between bimetallic metal-organic framework and TiO2: Band-structure engineering for effective photoelectrochemical water splitting (2022)

The article Heterojunction between bimetallic metal-organic framework and TiO2: Band-structure engineering for effective photoelectrochemical water splitting, written by Ji Won Yoon et al., was erroneously originally published electronically on the publisher’s internet portal (currently SpringerLink) on 17 May 2022 with the Acknowledgements.
Pharyngeal Function and Snoring Characteristics in Apneic and Nonapneic Snorers (1991)

Abnormalities in pharyngeal function, manifested even when the patients are awake, are thought to play an important role in the pathogenesis of sleep apnea. Tests of awake pharyngeal function continue to stimulate interest because it is hoped that they may allow physicians to distinguish patients with sleep apnea from those without it, and therefore reduce the number of unnecessary sleep studies. We elected to study two measures of pharyngeal function: changes in pharyngeal area with lung volume (PLVD) and changes in pharyngeal area in response to externally applied positive pressure, i.e., pharyngeal distensibility (Cph). Both measurements have been employed for assessment of pharyngeal function, and both are thought to reflect pharyngeal "floppiness." Measurement of PLVD is technically very simple, whereas the measurement of Cph is technically more complex. If the two measurements are highly correlated, it might be possible to replace the technically more difficult one by the simpler one. Consequently, the purpose of this study was two-fold: first, to examine the relationship between pharyngeal distensibility and lung volume dependence of pharyngeal area, and second, to compare these parameters in a large group of confirmed snorers with and without obstructive sleep apnea (OSA). We studied 75 unselected patients referred for the investigation of snoring and suspected sleep apnea. All patients had nocturnal polysomnography, pulmonary function tests, and measurement of pharyngeal areas at TLC, FRC, and residual volume (RV) employing the acoustic reflection technique. The area measurement at FRC was performed at zero and at 4.1 cm H2O positive airway pressure to calculate pharyngeal distensibility.(ABSTRACT TRUNCATED AT 250 WORDS)
Modeling the Combustion of a Solid Fuel Containing a Liquid Oxidizer Droplet (2012)

DOI: 10.2514/1.B34488 This work presents a physical model of the combustion behavior of a liquid oxidizer droplet with adjacent solid fuel. It is the first modeling attempt related to a proposed new potential class of liquid-oxidizer-enhanced solid propellants, where liquid oxidizer units/capsules are embedded in a solid fuel/propellant, revealing a theoretical specific impulse increase of up to 12%. A one-dimensional mathematical model is formulated, which describes the main characteristics of the microscale flamelet formed by a volatile (typically polymeric) fuel component and an adjacent endothermically evaporating oxidizer droplet. The model predicts fuel and oxidizer surface temperatures, fluxes, and flame height as functions of operating pressure and droplet size. The transient nature of the combustion processisemphasized,revealingacombustioncycleattheindividualdropletscale,withpressure-dependentaverage burning rates typical to solid propellants.
Meaningful control experiments (1997)

For a controls experiment to be meaningful, it should provide knowledge that cannot be gained from theory or simulation. The authors maintain that the value of experiments is proportional to their fidelity to an industrial motivating problem. Without this, claims regarding the efficacy of a control method cannot be substantiated to any degree more than they could via simulation. The control of a high speed milling spindle is reviewed as an example of a problem where only a prototype experiment is compelling.
Molecular Phylogenetic Analysis of Tryptophanyl-tRNA Synthetase of Actinobacillus actinomycetemcomitans (2008)

Aminoacyl-tRNA synthetase family enzymes are of particular interest for creating universal phylogenetic trees and understanding the gene flow as these enzymes perform the basic and analogous biochemical function of protein synthesis in all extant organisms. Among them, tryptophanyl-tRNA synthetase (Trp-RS) plays a foremost role in phylogeny owing to the close relationship with tyrosine-tRNA synthetase. In this study, the sequence of the gene Trp-RS was amplified using degenerated adenylation domain primers in the periodontal bacterium Actinobacillus actinomycetemcomitans. The sequence of the cloned PCR amplicon confirmed the adenylation domain sequence with glutamic acid residue, which is absent in five other oral bacteria used in this study as well as in a number of other bacteria described in the database. The Trp-RS sequence analysis prevailed the identify elements such as Rossmann-fold sequence and tRNA(Trp) binding domains including acceptor stem and anticodon. A theoretical model of Trp-RS of A. actinomycetemcomitans was generated. Guided docking of the ligand tryptophanyl-5'-AMP revealed a highly identical active site in comparison with the bacterial template. The phylogenetic positioning of Trp-RS among a group of oral bacterial species revealed that A. actinomycetemcomitans is closely related to Haemophilus influenzae, H. ducreyi and Pasteurella multocida.
A reliable method of manufacturing metallic hierarchical superhydrophobic surfaces (2009)

A method of manufacturing hierarchical metallic surfaces demonstrating superhydrophobic properties is presented. The surfaces showed apparent contact angles as high as 153° and sliding angles of 10° for 50–100 μl droplets. The Cassie-like model [A. B. D. Cassie and S. Baxter, Trans. Faraday Soc. 40, 546 (1944)], considering the hierarchical topography of the relief, predicts apparent contact angles in a satisfactory agreement with the measured values.
Field Deomonstration of the Sandia Wake Imaging System Capabilities at the Scaled Wind Farm Technology Facility. (2017)

Abstract not provided.
Frequency of use and Perceived helpfulness of Wellness Strategies for Bipolar and Unipolar Depression (2018)

Wellness strategies were commonly used by the majority of respondents. These strategies were subjectively helpful for most respondents and were associated with greater overall treatment effectiveness and increased helpfulness of medications, psychotherapy, and peer support groups. As such, wellness strategies should be considered while developing a holistic treatment plan for depression. Further research is needed to evaluate the antidepressant effects of specific wellness strategies to better understand the role of these interventions in the management of depression.
An intrinsic mechanism of secreted protein aging and turnover (2015)

The composition and functions of the secreted proteome are controlled by the life spans of different proteins. However, unlike intracellular protein fate, intrinsic factors determining secreted protein aging and turnover have not been identified and characterized. Almost all secreted proteins are posttranslationally modified with the covalent attachment of N-glycans. We have discovered an intrinsic mechanism of secreted protein aging and turnover linked to the stepwise elimination of saccharides attached to the termini of N-glycans. Endogenous glycosidases, including neuraminidase 1 (Neu1), neuraminidase 3 (Neu3), beta-galactosidase 1 (Glb1), and hexosaminidase B (HexB), possess hydrolytic activities that temporally remodel N-glycan structures, progressively exposing different saccharides with increased protein age. Subsequently, endocytic lectins with distinct binding specificities, including the Ashwell-Morell receptor, integrin αM, and macrophage mannose receptor, are engaged in N-glycan ligand recognition and the turnover of secreted proteins. Glycosidase inhibition and lectin deficiencies increased protein life spans and abundance, and the basal rate of N-glycan remodeling varied among distinct proteins, accounting for differences in their life spans. This intrinsic multifactorial mechanism of secreted protein aging and turnover contributes to health and the outcomes of disease.
Considerations for Studying Sex as a Biological Variable in Spinal Cord Injury (2020)

In response to NIH initiatives to investigate sex as a biological variable in preclinical animal studies, researchers have increased their focus on male and female differences in neurotrauma. Inclusion of both sexes when modeling neurotrauma is leading to the identification of novel areas for therapeutic and scientific exploitation. Here, we review the organizational and activational effects of sex hormones on recovery from injury and how these changes impact the long-term health of spinal cord injury (SCI) patients. When determining how sex affects SCI it remains imperative to expand outcomes beyond locomotor recovery and consider other complications plaguing the quality of life of patients with SCI. Interestingly, the SCI field predominately utilizes female rodents for basic science research which contrasts most other male-biased research fields. We discuss the unique caveats this creates to the translatability of preclinical research in the SCI field. We also review current clinical and preclinical data examining sex as biological variable in SCI. Further, we report how technical considerations such as housing, size, care management, and age, confound the interpretation of sex-specific effects in animal studies of SCI. We have uncovered novel findings regarding how age differentially affects mortality and injury-induced anemia in males and females after SCI, and further identified estrus cycle dysfunction in mice after injury. Emerging concepts underlying sexually dimorphic responses to therapy are also discussed. Through a combination of literature review and primary research observations we present a practical guide for considering and incorporating sex as biological variable in preclinical neurotrauma studies.
A case report of male breast cancer in a very young patient: What is changing? (2011)

Male breast cancer accounts for 1% of all breast cancer cases, and men tend to be diagnosed at an older age than women (mean age is about 67 years). Several risk factors have been identified, such as genetic and hormonal abnormalities. The present study reported the case of a 25-year-old man who was diagnosed with an advanced invasive ductal carcinoma; however, he did not have any important risk factors. Even though more data is emerging about this disease, more efforts to understand risk factors, treatment options and survival benefits are needed. In this case, we discussed the risk factors as well as the impaired fertility associated with breast cancer therapies.
The Influence of Endplate Morphology on Cage Subsidence in Patients With Stand-Alone Oblique Lateral Lumbar Interbody Fusion (OLIF) (2021)

This study for the first time demonstrated that endplate morphology correlates with cage subsidence after OLIF. Since relatively flat endplates with smaller concave angle significantly diminish the incidence of subsidence, the morphology of cage surface should be taken into consideration when designing the next generation of cage. In addition, precise measurement of the disc height to avoid over-distraction, and more anteriorly placement of the cage is suggested to reduce subsidence.
Reversion mutation of <i>i</i><sup>b</sup> oculocutaneous albinism to wild‐type pigmentation in medaka fish (2005)

We have previously identified three naturally occurring mutations in the medaka fish tyrosinase gene caused by transposable element insertions. Tyr-i(b) is one of these, containing the Tol2 element in the promoter region. Its homozygous carriers exhibit a weak oculocutaneous albino phenotype. We report here spontaneous reversion of the albino phenotype to the wild-type pigmentation, associated with excision of the Tol2 element. The newly arising mutant gene is inherited in the Mendelian fashion. Thus, oculocutaneous albinism is not strictly irreversible, at least in this organism and the results also indicate that the insertion of the Tol2 element is the main, and possibly the only, cause of the i(b) albinism. Importantly our data also suggest that medaka fish possess an active transposase.
Recognizing handwritten digits using hierarchical products of experts (2002)

The product of experts learning procedure can discover a set of stochastic binary features that constitute a nonlinear generative model of handwritten images of digits. The quality of generative models learned in this way can be assessed by learning a separate model for each class of digit and then comparing the unnormalized probabilities of test images under the 10 different class-specific models. To improve discriminative performance, a hierarchy of separate models can be learned, for each digit class. Each model in the hierarchy learns a layer of binary feature detectors that model the probability distribution of vectors of activity of feature detectors in the layer below. The models in the hierarchy are trained sequentially and each model uses a layer of binary feature detectors to learn a generative model of the patterns of feature activities in the preceding layer. After training, each layer of feature detectors produces a separate, unnormalized log probability score. With three layers of feature detectors for each of the 10 digit classes, a test image produces 30 scores which can be used as inputs to a supervised, logistic classification network that is trained on separate data.