gebhart/patrepeval huggingface dataset:
898-P: CGM Metrics Identify Dysglycemic States in Subjects with Normal OGTT from the TrialNet Pathway to Prevention Study (2019)

The TrialNet Pathway to Prevention Study (PtP) has enhanced our understanding of the progression through the stages of T1D identifying individuals at early stages of disease for prevention trials. Individuals with multiple islet AAb and normal OGTT are considered to be at Stage 1 T1D, and those with abnormal OGTT are at Stage 2 T1D. Our aim was to determine whether subtle forms of dysglycemia provide new clues about disease progression (Stage 3). 94 relatives of T1D probands from PtP underwent a 7-day CGM assessment (Dexcom G4 Platinum Professional) Three groups of relatives were evaluated: 1) Relatives at Stage 2 T1D whose 5-year risk for T1D progression is ∼70% (n=33); 2), relatives at Stage 1 T1D whose 5-year risk for T1D progression is ∼ 35% (n=51); and relatives with negative confirmed AAb and normal OGTT (n=10) whose 5-year risk for progression is &amp;lt;1%. CGM variations occur in a significant number of subjects with Stage 1 T1D (Figure) with increased variation in CGM glucose values assessed by mean amplitude of glucose excursion (MAGE) in relatives (n= 4 Stage 0; 31 Stage 1; and 27 Stage 2) at Stage 1 and Stage 2 T1D compared to that of low risk relatives (P = 0.005). Interstitial glucose &amp;gt;140 mg/dL was higher in relatives at Stage 1 and Stage 2 T1D compared to low risk relatives (P = 0.02). In conclusion, CGM metrics may be useful in identifying dysglycemia in at risk relatives with normal OGTT. Disclosure D.M. Wilson: Advisory Panel; Self; Tolerion, Inc. Research Support; Self; Beta Bionics, Dexcom, Inc., Medtronic. P. Nelson: None. D. Scheinker: Advisory Panel; Self; Carta Healthcare. S. Pietropaolo: None. M. Acevedo-Calado: None. M. Ebrahimi: None. A. Steck: None. J.L. Dunne: None. C. Greenbaum: Research Support; Self; Janssen Research &amp; Development. M. Pietropaolo: None. Funding National Institutes of Health
Regional Control of Head and Neck Melanoma with Selective Neck Dissection (2011)

Objective Historically, patients with cervical metastases from melanoma of the head and neck were treated with a modified radical or radical neck dissection. The purpose of our study was to evaluate the efficacy of therapeutic selective neck dissection (SND) in this high‐risk population. Method Retrospective, single‐cohort study from a prospective institutional database. Patients underwent therapeutic SND for clinically node positive head and neck melanoma (n = 14) or pathologically node positive disease after sentinel lymph node biopsy (SLNB) (n = 27). Univariate and multivariate analyses were conducted. Primary end points were regional recurrence and regional recurrence free survival. Results Forty‐one patients underwent therapeutic SND from 2001 to 2010. The median number of positive nodes was 1 (range, 1‐16 months). Twenty‐six patients (63%) received adjuvant radiation and 23 patients (56%) received adjuvant immunotherapy or chemotherapy. The median follow‐up time was 17 months (range, 1‐116 months). Regional control was achieved in 29 patients (71%). Median regional recurrence‐free survival was 21 months (range, 1‐116 months). Advanced age was a significant predictor of regional recurrence ( P =. 012) while tumor depth, extracapsular spread, number of nodes positive, prior SLNB, extent of neck dissection, adjuvant radiotherapy, and adjuvant immunotherapy were not significant. Conclusion Therapeutic SND with frequent use of adjuvant radiation therapy is effective in achieving regional control of head and neck melanoma with cervical metastases. Older patients may be at increased risk of regional recurrence after SND for head and neck melanoma.
Practical Fluorescence Spectroscopy (2019)

Presenting a detailed, hands-on approach to fluorescence spectroscopy, this book describes experiments that cover basic spectroscopy and advanced aspects of fluorescence spectroscopy. It emphasizes practical guidance, providing background on fundamental concepts as well as guidance on how to handle artifacts, avoid common errors, and interpret data. Nearly 150 experiments from biophysics, biochemistry, and the biomedical sciences demonstrate how methods are applied in practical applications. The result is a hands-on guide to the most important aspects of fluorescence spectroscopy, from steady-state fluorescence to advanced time-resolved fluorescence. Provides a complete overview of nearly 150 experiments using fluorescence spectroscopy, from basic to advanced applications Presents laboratory methods using a variety of instrumental setups with detailed discussion of data analysis and interpretations Covers steady-state phenomena, time-resolved phenomena, and advanced methods Spans biophysical, biochemical, and biomedical applications Describes related concepts, theory, and mathematical background as well as commercially available instruments used for measurements
Recovery and reuse of heteropolyacid catalyst in liquid reaction medium through reversible encapsulation in Cu3(BTC)2 metal–organic framework (2012)

The solvent dependent solubility of HKUST-1 metal–organic framework (MOF) with encapsulated Keggin 12-tungstophosphoric acid (HPW@Cu3(BTC)2) was exploited to liberate homogeneous heteropolyacid catalyst in a reaction medium and to recover the catalyst by encapsulation in the MOF upon addition of hexane. The application of the new Keggin type heteropolyacid catalyst recovery concept was demonstrated in the esterification of acetic acid with 1-propanol and salicylic acid with ethanol.
Optimization of Sizing and Battery Cycle Life in Battery/Ultracapacitor Hybrid Energy Storage Systems for Electric Vehicle Applications (2014)

Electric vehicle (EV) batteries tend to have accelerated degradation due to high peak power and harsh charging/ discharging cycles during acceleration and deceleration periods, particularly in Urban driving conditions. Oversized energy storage system (ESS) meets the high power demand; however, in tradeoff with increased ESS size, volume, and cost. In order to reduce overall ESS size and extend battery cycle life, battery/ultracapacitor (UC) hybrid ESS (HESS) has been considered as a solution in which UCs act as a power buffer to charging/discharging peak power. In this paper, a multiobjective optimization problem is formulated to minimize the overall ESS size, while maximizing the battery cycle life according to the assigned penalty functions. An integrated framework for HESS sizing and battery cycle life optimization applied in a midsize EV, using an Autonomie simulation model, is described and illustrated in this paper. This multidimensional optimization is realized by a sample-based global search oriented DIviding RECTangles (DIRECT) algorithm. The optimization results under Urban Dynamometer Driving Schedule (UDDS) are compared with the battery-only ESS results, which demonstrate significant battery cycle life extension of 76% achieved by the optimized HESS with 72 UC cells.
Monitoring Multi-Organ Stiffness Changes with MR Elastography in Amyloidosis Patients Treated with Stem Cell Therapy (2023)

Light chain (AL) cardiac amyloidosis is a disease where abnormal proteins are deposited in multiple organs and is associated with elevated tissue stiffness. In cases with poor prognosis, autologous hematopoietic stem cell transplantation (ASCT) is used for therapy. Organ response monitoring is currently limited and challenging. The objective of this study was to evaluate the feasibility of using magnetic resonance elastography (MRE) to monitor stiffness changes in multiple organs pre- and post- ASCT therapy. At 3 months post therapy, significant reduction in MRE stiffness (p&amp;lt;0.001) was observed in organs that exhibited successful therapy response (defined by 9 month clinical outcomes).
First Principles Study of Dendritic Carbazole Photosensitizer Dyes Modified with Different Conjugation Structures (2019)

Abstract In the pursuit of efficient organic dyes first principles calculations were carried out by using density functional theory (DFT). The electronic and optical properties of D−D‐π‐A carbazole dendritic donor and cyanoacrylic acid acceptor conjugated through thiophene and oxadiazole structures are being reported. The findings of this work point to the dependence of the structural modifications especially changes in length of conjugation molecule appeared to notably affect the properties of the dyes. The positions of highest occupied molecular orbital (HOMO) and lowest molecular orbitals (LUMO) energy levels are found suitable for electron reduction and electron injection processes respectively. The addition of another oxadiazole ring as well as replacement of a thiophene ring with existing oxadiazole in the conjugating bridge appeared to reduce the HOMO‐LUMO energy gap. TD‐DFT excitation spectra calculated at PBE, B3LYP and CAM−B3LYP levels of theory are discussed in detail to shed light on charge transfer process in the dye molecules and the calculated results are found consistent with reported experimental work. The changes in length and structure of π‐spacer chain are discussed to analyze the photon to current conversion efficiency.
Pulse-Firing Neural Chips for Hundreds of Neurons (1989)

We announce new CMOS synapse circuits using only three and four MOSFETs/synapse. Neural states are asynchronous pulse streams, upon which arithmetic is performed directly. Chips implementing over 100 fully programmable synapses are described and projections to networks of hundreds of neurons are made.
Joint Fractional Time Allocation and Beamforming for Downlink Multiuser\n MISO Systems (2017)

It is well-known that the traditional transmit beamforming at a base station\n(BS) to manage interference in serving multiple users is effective only when\nthe number of users is less than the number of transmit antennas at the BS.\nNon-orthogonal multiple access (NOMA) can improve the throughput of users with\npoorer channel conditions by compromising their own privacy because other users\nwith better channel conditions can decode the information of users in poorer\nchannel state. NOMA still prefers that the number of users is less than the\nnumber of antennas at the BS transmitter. This paper resolves such issues by\nallocating separate fractional time slots for serving the users with similar\nchannel conditions. This enables the BS to serve more users within the time\nunit while the privacy of each user is preserved. The fractional times and\nbeamforming vectors are jointly optimized to maximize the system's throughput.\nAn efficient path-following algorithm, which invokes a simple convex quadratic\nprogram at each iteration, is proposed for the solution of this challenging\noptimization problem. Numerical results confirm its versatility.\n
A heat engine made of quantum dot molecules with high figure of merits (2016)

The transport of electrons through serially coupled quantum dot molecules (SCQDM) is investigated theoretically for application as an energy harvesting engine (EHE), which converts thermal heat to electrical power. We demonstrate that the charge current driven by a temperature bias shows bipolar oscillatory behavior with respect to gate voltage due to the unbalance between electrons and holes, which is different from the charge current driven by an applied bias. In addition, we reveal a Lenz's law between the charge current and the thermal induced voltage. The efficiency of EHE is higher for SCQDM in the orbital depletion situation rather than the orbital filling situation, owing to the many-body effect. The EHE efficiency is enhanced with increasing temperature bias, but suppressed as the electron hopping strength reduces. The fluctuation of QD energy levels at different sites also leads to a reduction of EHE efficiency. Finally, we demonstrate direction-dependent charge currents driven by the temperature bias for application as a novel charge diode.
Green DSL: Energy-Efficient DSM (2009)

Dynamic spectrum management (DSM) has been recognized as a key technology for tackling multi-user crosstalk interference for DSL broadband access. Up to now, DSM design has mainly been focusing on maximization of data rates. However, recently, reducing the total power has become a main target, as IT power consumption has been identified as a significant contributor to global warming. In this paper we extend traditional DSM design towards a much wider energy-efficient scope and show how to tackle the corresponding optimization problems. The impact of this 'green DSL' approach is evaluated for practice with some surprisingly good numerical results. Furthermore bounds are provided on the trade-off between data rate performance and power saving.
Simulations of ultrathin, ultrashort double-gated MOSFETs with the density gradient transport model (2003)

We report the results of numerical simulation of nanoscale SOI structures under highly non-equilibrium conditions with the Density Gradient model. The simulations have been carried out with the general purpose device simulator DESSIS. We show that 2D quantum mechanical effects are important for the structures under investigation. We demonstrate that our implementation of the DG model is robust and enables efficient simulation far from equilibrium, for both the drift-diffusion and hydrodynamic transport model.
Challenges Towards Developing a High Fidelity Database for Validating High Strain Rate Composite Material Models (2021)

View Video Presentation: https://doi.org/10.2514/6.2021-1404.vid A method for performing verification and validation for composites subjected to impact loading was previously outlined by Pankow [1]. This paper explores the challenges associated with developing a high fidelity database of experimental data for validating experimental models. Specifically, this paper explores the rate dependent response of the failure envelope and how it changes as the rate is increase from static to impact. Combined loading experiments were performed to determine different combinations of axial and shear stress to find multiple points on the failure envelope. Samples were loaded at quasi-static rates of 10-4 strain per second to dynamic rates of 600 strain per second to determine the experimental failure envelope in both tension and compression. The experimental data was then fitted to failure theories to understand how these theories capture the rate dependent response of the experimental data. This understanding will allow for a determination of how rate dependent effects should be captured in computational tools to predict the correct failure initiation of composites.
ChemInform Abstract: Chemical Vapor Deposition Experiments Using New Fluorinated Acetylacetonates of Calcium, Strontium, and Barium. (1989)

Abstract The complexes (I) and (II) are prepared from the reaction of an excess of the corresponding fluorinated acetylacetone with the metal.
Mechanism of coumarin action: significance of vitamin K epoxide reductase inhibition (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of coumarin action: significance of vitamin K epoxide reductase inhibitionD. S. Whitlon, J. A. Sadowski, and J. W. SuttieCite this: Biochemistry 1978, 17, 8, 1371–1377Publication Date (Print):April 18, 1978Publication History Published online1 May 2002Published inissue 18 April 1978https://pubs.acs.org/doi/10.1021/bi00601a003https://doi.org/10.1021/bi00601a003research-articleACS PublicationsRequest reuse permissionsArticle Views1650Altmetric-Citations299LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The same human alloreactive T cell clone can help both B lymphocytes and specific cytotoxic precursors. (1984)

Human alloreactive proliferating T cell clones have been compared for their capacity to provide help for B cell activation and the generation of a specific cytotoxic response. The results demonstrate that, when triggered by the relevant alloantigen, the same T cell clone can induce a strong polyclonal B cell activation and serve as the only source of helper cells for the generation of a specific cytotoxic response by any source of CTL precursors against any stimulator cell present in culture.
Consideration of optimal number of poles and frequency for high-efficiency permanent magnet motor (2014)

This paper describes an approach to the optimal design of high efficiency permanent magnet reluctance motors (PRM) based on the Taguchi method coupled with finite element analysis (FEA) because of the requirements of the impending IE4 Super Premium Efficiency classification. The objectives of the optimal design are to increase the efficiency and to decrease an amount of the permanent magnet of the motor. We present multi-objective optimization design results in number of poles and frequency for PRM using Taguchi Method.
Proteomics of Aqueous Humor as a Source of Disease Biomarkers in Retinoblastoma (2022)

Aqueous humor (AH) can be easily and safely used to evaluate disease-specific biomarkers in ocular disease. The aim of this study was to identify specific proteins biomarkers in the AH of retinoblastoma (RB) patients at various stages of the disease. We analyzed the proteome of 53 AH samples using high-resolution mass spectrometry. We grouped the samples according to active vitreous seeding (Group 1), active aqueous seeding (Group 2), naive RB (group 3), inactive RB (group 4), and congenital cataracts as the control (Group 5). We found a total of 889 proteins in all samples. Comparative parametric analyses among the different groups revealed three additional proteins expressed in the RB groups that were not expressed in the control group. These were histone H2B type 2-E (HISTH2B2E), InaD-like protein (PATJ), and ubiquitin conjugating enzyme E2 V1 (UBE2V1). Upon processing the data of our study with the OpenTarget Tool software, we found that glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and CD44 were more highly expressed in the RB groups. Our results provide a proteome database regarding AH related to RB disease that may be used as a source of biomarkers. Further prospective studies should validate our finding in a large cohort of RB patients.
HEVC-EPIC: Edge-preserving interpolation of coded HEVC motion with applications to framerate upsampling (2017)

We propose a method to obtain a high quality motion field from decoded HEVC motion. We use the block motion vectors to establish a sparse set of correspondences, and then employ an affine, edge-preserving interpolation of correspondences (EPIC) to obtain a dense optical flow. Experimental results on a variety of sequences coded at a range of QP values show that the proposed HEVC-EPIC is over five times as fast as the original EPIC flow, which uses a sophisticated correspondence estimator, while only slightly decreasing the flow accuracy. The proposed work opens the door to leveraging HEVC motion into video enhancement and analysis methods. To provide some evidence of what can be achieved, we show that when used as input to a framerate upsampling scheme, the average Y-PSNR of the interpolated frames obtained using HEVC-EPIC motion is slightly lower (0.2dB) than when original EPIC flow is used, with hardly any visible differences.
Centralized Hybrid Equalization for Cell Free mMIMO mmWave based Systems (2022)

Cell-free massive multiple input multiple output (CFmMIMO) is one of the promising technologies for beyond 5G/6G wireless communications due to its advantages in overcoming the inter-cell interferences constraints in ultra-dense networks. In this paper, we propose a low complexity analog precoder with a centralized hybrid analog-digital multi-user equalizer for millimeter-wave (mmWave) CF mMIMO systems. In the transmitter, a low complexity analog precoder is applied based on the partial channel state information (CSI) knowledge, i.e., only the average angle of departure (AoD) information. While in the centralized hybrid receiver, the central unit (CU) handles all processing that requires access to the global CSI. Herein, the analog coefficients of the equalizer are obtained by minimizing the mean square error (MSE) between the transmit and receive signals using the weighted Frobenius norm as a metric, whereas an optimum linear MSE equalizer is used to get the digital part. We also compare the considered CF scenario with the small cells (SCs) based one for different hybrid schemes. The results show that the proposed precoder combined with the hybrid equalizer can achieve very close results to a fully digital counterpart. Moreover, the performance of the considered CF scenario is better than the SCs based one for all hybrid schemes.
Comparison of quasiclassical trajectory calculations to accurate quantum mechanics for state-to-state partial cross sections at low total angular momentum for the reaction D+H2→HD+H (1989)

We compare the results of classical simulations to accurate quantum studies for the reaction D+H2(v=0, j=1)→HD(v′, j′)+H (where v and v′ are vibrational quantum numbers and j and j′ are rotational quantum numbers) on a double many-body expansion (DMBE) potential energy surface. The quantal results presented here are converged to three significant figures. We consider orbital angular momenta 0 and 1 and total angular momenta 0–2. The total energies considered, Etot=0.983–1.333 eV, correspond to relative translational energy Erel=0.70–1.05 eV for the v=0, j=1 vibrational–rotational state. For J=1 and odd parity, the number of channels included is up to 453 and the number of open channels is up to 177. For J=2 and even parity, the number of channels is 630 and of open channels is 147.
Implicit B-Spline Surface Reconstruction (2014)

This paper presents a fast and flexible curve, and surface reconstruction technique based on implicit B-spline. This representation does not require any parameterization and it is locally supported. This fact has been exploited in this paper to propose a reconstruction technique through solving a sparse system of equations. This method is further accelerated to reduce the dimension to the active control lattice. Moreover, the surface smoothness and user interaction are allowed for controlling the surface. Finally, a novel weighting technique has been introduced in order to blend small patches and smooth them in the overlapping regions. The whole framework is very fast and efficient and can handle large cloud of points with very low computational cost. The experimental results show the flexibility and accuracy of the proposed algorithm to describe objects with complex topologies. Comparisons with other fitting methods highlight the superiority of the proposed approach in the presence of noise and missing data.