gebhart/patrepeval huggingface dataset:
UV-assisted 3D-printing of soft ferrite magnetic components for power electronics integration (2017)

For ease of fabricating and integrating ferrite magnetic components in power electronics circuits to improve the power density and efficiency, we explored a paste-extrusion additive manufacturing method to fabricate ferrite core and conductive winding in a single platform. A UV-sensitive low-temperature (<; 950 °C) sinterable NiCuZn ferrite paste formulated by ourselves as well as a commercial nanosilver paste were used as feed materials for 3D printing ferrite cores and silver windings, respectively. A planar inductor with one turn of silver winding embedded was 3D-printed to demonstrate the feasibility of fabrication. After the 3D structure of the planar inductor was printed, it was sintered to 920 °C for 14hrs. The sintered ferrite paste had relative permeability of 70, and the sintered nanosilver paste had a DC resistivity 1.5 times of pure bulk silver. The measured inductance and DC winding resistance of the 3D-printed planar inductor after sintering were 792 nH and 15 mΩ, respectively. The measured value of both inductance and DC resistance were in less than 10% error with those predicted by 3D finite-element-analysis simulation. Microstructure of the sintered planar inductor was characterized by scanning electron microscopy (SEM).
The high expression of elastases, observed in apelin deficient mice, could contribute to premature wear of elastic fibers and vascular stiffness. (2021)

Abstract Vascular stiffness is often the main cause of arterial hypertension and its complications including atherosclerosis, observed during obesity. However, the mechanisms leading to this rigidity or the preventing factors are misknown. We hypothesized that apelin, known for its beneficial effects on lipid, inflammatory, and vascular metabolism, could be a protective factor against vascular stiffness. We used mice deficient for the apelin gene (KO-APL) and compared with wild-type mice (WT) at the level of metabolic markers and inflammations of white adipose tissue (WAT), as well as aortic functional and anatomical parameters. KO-APL mice developed an inflammation associated with significant remodeling of WAT, in particular with the protease expressions such as neutrophil elastase or cathepsin S. From a vascular point of view, these same elastases are involved in the fragmentation of elastic fibers, explaining the increase in vascular velocity of pulse wave and arterial hypertension. Interestingly, univariate correlation analysis showed that the inflammation markers and protease expression of WAT were associated with remodeling of the vascular wall. Our results suggest that the modifications induced by the absence of apelin particularly in WAT, could facilitate the expression of elastases and the rupture of elastic fibers, necessary to maintain elastance. This discovery is fundamental because the synthesis of elastic fibers stops as of adolescence and is not renewed during the entire life of human. The preservation of these fibers is therefore critical in maintaining vascular homeostasis. Thus, Apelin could be an interesting therapeutic route to protect the premature wear of elastic fibers.
Development, Optimization, and In Vitro Evaluation of Novel Oral Long-Acting Resveratrol Nanocomposite In-Situ Gelling Film in the Treatment of Colorectal Cancer (2021)

This study aimed to develop and evaluate sustained-release (SR) long-acting oral nanocomposites in-situ gelling films of resveratrol (Rv) to treat colorectal cancer. In these formulations, Rv-Soy protein (Rv-Sp) wet granules were prepared by the kneading method and then encapsulated in the sodium alginate (NA) dry films. The prepared nanocomposite in-situ gels films were characterized using dynamic light scattering, Fourier-transform infrared spectroscopy, X-ray diffraction, and scanning electron microscopy. The optimized formulations were further evaluated based on drug encapsulation efficiency, pH-drug release profile, swelling study, and storage time effects. The optimized formulation was tested for its anticancer activity against colorectal cancer cells using the cytotoxicity assessment, apoptosis testing, cell cycle analysis, gene expression analysis, and protein estimation by the reverse-transcriptase polymerase chain reaction and enzyme-linked immunosorbent assay methods, respectively. The optimum film showed encapsulation efficiency of 97.87% ± 0.51 and drug release of 14.45% ± 0.043 after 8 h. All physiochemical characterizations confirmed, reasoned, and supported the drug release experiment's findings and the encapsulation assay. The Rv nanocomposite formulation showed concentration-dependent cytotoxicity enhanced apoptotic activity as compared to free Rv (<i>p</i> < 0.05). In addition, Rv nanocomposite formulation caused a significant increase in Bcl-2-associated protein X (<i>Bax</i>) and a decrease in expression of B-cell lymphoma 2, interleukin 1 beta, IL-6, and tumor necrosis factor-alpha (<i>Bcl2</i>, <i>IL-1β</i>, <i>IL-6</i>, and <i>TNF-α</i> respectively) compared to that of free Rv in HCT-116 cells. These results suggest that long-acting Rv nanocomposite gels could be a promising agent for colorectal cancer treatment.
Resource allocation of 3-PLP LDM system using a Lagrange multiplier method (2023)

The increasing amount of data transmitted through digital broadcasting and communication channels requires efficient transmission methods that make the most of limited resources such as frequency, time, and power. The layered division multiplexing (LDM) system, which is adopted by the Advanced Television Systems Committee (ATSC) 3.0 standard, is considered one of a solution for achieving efficient transmission. Additionally, the layered time-division multiplexing (LTDM) and time layered division multiplexing (TLDM) systems have been developed as well. These layered transmission systems, utilizing multiple physical layer pipes (PLPs), offer a wide range of services including mobile and rooftop TV. To compare the efficiencies of different layered transmission systems, the article introduces the concept of normalized channel capacity. This measure allows for a fair comparison among the systems by taking into account the specific channel capacity requirements of each service. By summing the normalized channel capacities, a method is proposed to select the most efficient transmission system among the four systems: LDM, LTDM, TLDM, and time division multiplexing (TDM). The Lagrange multiplier method is employed to find the parameters that maximize the sum of the normalized channel capacities in these systems. Through simulations conducted with the determined parameters, it is demonstrated that the LDM system exhibits the highest efficiency among the four systems.
On adaptive video streaming with predictable streaming performance (2014)

Adaptive video streaming is an essential tool for improving the performance of video delivery over mobile networks. By dynamically switching between different bit-rate versions of the same video, adaptive video streaming can compensate for and adapt to the ever-changing network conditions inherent in today's 3G/4G networks. However, existing adaptive streaming algorithms, both academic and commercial ones, do not offer any prediction on the streaming performance of future streaming sessions, nor allow the content providers or users to explicitly control the tradeoff between streaming performance and video quality. This study tackles this fundamental challenge by developing a novel framework called Throughput-Differentiated-Rate-Adaptive Post-Streaming-Rate-Analysis (TDRA-PSRA) based on a new statistical model that directly relates past bandwidth statistics to future streaming performance. Extensive simulation results obtained from real-world mobile network trace data revealed three remarkable properties of TDRA-PSRA: (a) the actual average streaming performance is very close to the target set forth by the ICPs/users; (b) it enables the ICPs/users to control the tradeoff between streaming performance and video quality; (c) it offers a mean to directly control the frequency of bit-rate switches — a key factor to subjective video quality.
Noninvasive Control of the Power Transferred to an Implanted Device by an Ultrasonic Transcutaneous Energy Transfer Link (2014)

Ultrasonic transcutaneous energy transfer is an effective method for powering implanted devices noninvasively. Nevertheless, the amount of power harvested by the implanted receiver is sensitive to the distance and orientation of the external transmitting transducer attached to the skin with respect to the implanted receiving transducer. This paper describes an ultrasonic power transfer link whose harvested power is controlled by an inductive link. A small (5 μF) storage capacitor voltage, which is part of the implanted unit, is allowed to swing between 3.8 and 3.5 V using hysteretic control. The two control states are indicated by excitation (while the implanted storage capacitor voltage decreases) or the absence of excitation of an implanted coil that is magnetically coupled to an external coil attached to the skin surface. A 35 mW Ultrasonic Transcutaneous Energy Transfer link was fabricated using two piezoelectric transducers of equal size (Fuji Ceramics C-2 PZT disc 15 mm × 3 mm) operated at a vibration frequency of 720 kHz. By applying the proposed hysteretic control, the captured power was effectively regulated for implantation depths of up to 85 mm.
Lean Smart Parking (2014)

Cities around the world are seeing an increased use of on-street parking sensors. Sensor data can serve a variety of purposes, including helping drivers find nearby spaces through in-car guidance apps, guiding law enforcement officers to parking violations, and aiding policy decision-making. This article examines cost-effective strategies for collecting high-quality data with sensors. The author illustrates the potential of lean smart parking through a discussion of what high-quality data is and an examination of the accuracy of sampling methods.
Compact illumination and camera systems for 2D and 3D sensing in automobile applications (2005)

The use of optical sensor principles in automotive applications is growing fast due to the increasing demand for driver assistance and passenger security systems. Automotive applications demand for compact, low volume or particularly flat microoptical systems for recognition of passengers and obstacles, measuring distances, eye movements etc. The optical concepts need to reach a high level of optical- and opto-electronic integration and demand a high degree of modularity to be able to address different requirements in a flexible way. In this context, the design and realization of several compact optical modules for the sensor as well as for the illumination side are presented, e.g. a wide angle camera optics (FOV = 90° and f-number = 1.1), laser and LED-based illumination modules and an ultra thin camera of 0,2 mm length, based on the apposition eye principle. The specification of these microoptical modules is oriented to fulfil physical as well as economical requirements. In particular, a great compactness and easy scalable fabrication technologies are essential to fulfil the different boundary constraints.
Discovery of the Pyrrolo[2,1-<i>f</i>][1,2,4]triazine Nucleus as a New Kinase Inhibitor Template (2004)

The pyrrolo[2,1-f][1,2,4]triazine nucleus was identified as a novel kinase inhibitor template which effectively mimics the well-known quinazoline kinase inhibitor scaffold. Attachment of a 4-((3-chloro-4-fluorophenyl)amino) substituent to the template provided potent biochemical inhibitors of the tyrosine kinase activity of EGFR, as well as inhibition of cellular proliferation of the human colon tumor cell line DiFi. Attachment of a 4-((3-hydroxy-4-methylphenyl)amino) substituent provided potent inhibitors of VEGFR-2 which also showed effects on the VEGF-dependent proliferation of human umbilical vein endothelial cells. Biological activity was maintained with substitution at positions 5 or 6, but not 7, suggesting that the former positions are promising sites for introducing side chains which modulate physicochemical properties. Preliminary inhibition studies with varying ATP concentrations suggest that, like the quinazoline-based kinase inhibitors, the pyrrolotriazine-based inhibitors bind in the ATP pocket.
Propagation loss in single-mode GaAs-AlGaAs microring resonators: measurement and model (2001)

We report propagation loss measurements in single-mode GaAs-AlGaAs racetrack microresonators with bending radii from 2.7 /spl mu/m to 9.7 /spl mu/m. The experimental data were found to be in good agreement with a physical-loss model which accounts for the bending loss, the scattering loss due to surface roughness on the waveguide sidewalls, and the transition loss at the straight-to-bend waveguide junctions. The model also enables us to identify the dominant loss mechanisms in semiconductor microcavities. We found that for racetracks with large bending radii (greater than 4 /spl mu/m, in our case) the loss due to surface-roughness scattering in the curved waveguides dominates, whereas for small-radius rings, the modal mismatch at the straight-to-bend waveguide junctions causes the biggest loss. This result suggests that circular-shaped rings are preferable in the realization of ultrasmall low-loss microcavities. We also show that the round-trip propagation loss in small-radius racetrack microresonators can be minimized by introducing a lateral offset at the straight-to-bend waveguide junctions.
ChemInform Abstract: Ytterbium Triflate and High Pressure‐Mediated Ring Opening of Epoxides with Amines. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Potent and comparable vasodilator actions of A- and B-calcitonin-gene-related peptides on the superficial subcutaneous vasculature of man (1988)

1. Vasoactivity of human A- and B-calcitonin-gene-related peptides was studied in normal subjects, using reflectance plethysmography to measure relative changes in blood flow produced by superficial subcutaneous injections of the peptides. 2. Injection of 10(-11) mol of either peptide caused an immediate 200% increase in local blood flow and prolonged hyperaemia lasting up to 3 h. The hyperaemic response to 10(-13) mol of each peptide was significantly (P less than 0.01) smaller and shorter in duration than that elicited by 10(-11) mol of the same peptide, and 10(-15) mol of both peptides produced no hyperaemia other than that attributable to needle insertion alone. 3. At all three dosages examined, there were no significant differences between A- and B-calcitonin-gene-related peptides in magnitude or time course of the hyperaemic response. 4. Human A- and B-calcitonin-gene-related peptides are therefore potent vasodilators in man, causing comparable dose-related vasodilatation in the superficial tissues.
Million Cycle Overwritable Phase Change Optical Disk Media (1989)

GeTe-Sb2Te3-Sb pseudo ternary components alloy shows laser induced rapid crystallization and amorphous change phenomena. Films of non stoichiometric GeTe-Sb2Te3-Sb can be crystallized using laser pulses less than 100ns duration. The crystalline structure shows the cubic structure. The time it takes to laser crystallize varies Sb concentration. And increasing the Sb concentration leads to increased crystallization temperature. The crystallization temperature of 180 C and more than 1200h stable of acceleration test of 80C 80% RH environment. Thin film disk structure of 20nm active layer produce more than million cycle over-write BER(bit error rate) stability. I would like to discuss the degradation model of pinhole generation in phase change disk media.
Error of finite basis expansions in time-dependent calculations of atom-laser interaction (2005)

We propose a method to quantitatively estimate the error made with a finite basis expansion in time-dependent calculations. This method is applied to the hydrogen atom in intense laser fields and used to compare different basis sets with each other. We also show how to construct a Gaussian basis set suitable for the description of ionization dynamics in intense laser fields.
A half-implant device on fingernails (2014)

Hand gesture feedback systems using tactile or visual information can only be used in given situations because of the limitations of the device features such as the need for a battery. In this paper, a half-implant device is suggested. The half-implant device consists of a radio frequency (RF) receiving antenna, small electronic parts, and UV gel. The UV gel is used to glue the parts onto the filed user's nail and cover the parts meant to be waterproof. The device receives power from the RF antenna; therefore, it does not require a battery to function. The device notifies whether the finger is in a gesture space by lighting an LED or activating a vibration motor. The primary benefit of this device is that the user can feel hand gesture feedback, anytime and anywhere. The device can be placed on the users' fingernail for approximately three weeks. To verify the devices' influence on the users' gesture task, we conducted a preliminary user study. The experiment revealed that the tactile notification reduced the task time by 2.62 seconds compared to that of the test with no feedback. We also investigated user's acceptability of this kind of technology. It revealed that this technology is acceptable only when it can be removed in the user's will and used in daily-life.
Reactive Molecular Dynamics Simulations and Quantum Chemistry Calculations To Investigate Soot-Relevant Reaction Pathways for Hexylamine Isomers (2020)

Sooting tendencies of a series of nitrogen-containing hydrocarbons (NHCs) have been recently characterized experimentally using the yield sooting index (YSI) methodology. This work aims to identify soot-relevant reaction pathways for three selected C<sub>6</sub>H<sub>15</sub>N amines, namely, dipropylamine (DPA), diisopropylamine (DIPA), and 3,3-dimethylbutylamine (DMBA) using ReaxFF molecular dynamics (MD) simulations and quantum mechanical (QM) calculations and to interpret the experimentally observed trends. ReaxFF MD simulations are performed to determine the important intermediate species and radicals involved in the fuel decomposition and soot formation processes. QM calculations are employed to extensively search for chemical reactions involving these species and radicals based on the ReaxFF MD results and also to quantitatively characterize the potential energy surfaces. Specifically, ReaxFF simulations are carried out in the <i>NVT</i> ensemble at 1400, 1600, and 1800 K, where soot has been identified to form in the YSI experiment. These simulations account for the interactions among test fuel molecules and pre-existing radicals and intermediate species generated from rich methane combustion, using a recently proposed simulation framework. ReaxFF simulations predict that the reactivity of the amines decrease in the order DIPA > DPA > DMBA, independent of temperature. Both QM calculations and ReaxFF simulations predict that C<sub>2</sub>H<sub>4</sub>, C<sub>3</sub>H<sub>6</sub>, and C<sub>4</sub>H<sub>8</sub> are the main nonaromatic soot precursors formed during the decomposition of DPA, DIPA, and DMBA, respectively, and the associated reaction pathways are identified for each amine. Both theoretical methods predict that sooting tendency increases in the order DPA, DIPA, and DMBA, consistent with the experimentally measured trend in YSI. This work demonstrates that sooting tendencies and soot-relevant reaction pathways of fuels with unknown chemical kinetics can be identified efficiently through combined ReaxFF and QM simulations. Overall, predictions from ReaxFF simulations and QM calculations are consistent, in terms of fuel reactivity, major intermediates, and major nonaromatic soot precursors.
IL-23 Enhances the Inflammatory Cell Response in <i>Cryptococcus neoformans</i> Infection and Induces a Cytokine Pattern Distinct from IL-12 (2006)

IL-23, a heterodimeric cytokine composed of the p40 subunit of IL-12 and a novel p19 subunit, has been shown to be a key player in models of autoimmune chronic inflammation. To investigate the role of IL-23 in host resistance during chronic fungal infection, wild-type, IL-12- (IL-12p35-/-), IL-23- (IL-23p19-/-), and IL-12/IL-23- (p40-deficient) deficient mice on a C57BL/6 background were infected with Cryptococcus neoformans. Following infection, p40-deficient mice demonstrated higher mortality than IL-12p35-/- mice. Reconstitution of p40-deficient mice with rIL-23 prolonged their survival to levels similar to IL-12p35-/- mice. IL-23p19-/- mice showed a moderately reduced survival time and delayed fungal clearance in the liver. Although IFN-gamma production was similar in wild-type and IL-23p19-/- mice, production of IL-17 was strongly impaired in the latter. IL-23p19-/- mice produced fewer hepatic granulomata relative to organ burden and showed defective recruitment of mononuclear cells to the brain. Moreover, activation of microglia cells and expression of IL-1beta, IL-6, and MCP-1 in the brain was impaired. These results show that IL-23 complements the more dominant role of IL-12 in protection against a chronic fungal infection by an enhanced inflammatory cell response and distinct cytokine regulation.
Quantum interference and conductance in silicon quantum wires (1999)

We present the findings of quantized conductance (QC), Coulomb staircase (CS) and local tunneling spectroscopy (LTS) techniques which reveal the single-hole confinement and charging phenomena in the smooth and modulated quantum wires created electrostatically inside self-assembly longitudinal (SLQW) and lateral (SLaQW) silicon quantum wells. The current- voltage (CV) characteristics obtained are in a good agreement with the data of the theoretical calculations taking account of quantum interference effects in the field-dependent value of the transmission coefficient through the quantum wires that exhibit the different degree of a modulation.
Unravelling the functional genomics of the human CYP2D6 gene locus (2001)

Division of Molecular Toxicology, IMM, Karolinska Institutet, Stockholm, Sweden and bDepartment of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN 38105, USA
Mode-Locked Ho<sup>3+</sup>-Doped ZBLAN Fiber Laser at 1.2 &lt;italic&gt;μ&lt;/italic&gt;m (2016)

A mode-locked Ho <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> -doped ZBLAN fiber laser at 1.2 μm was demonstrated for the first time employing a nonlinear polarization rotation technique for mode-locking. The laser was pumped at 1137 nm by the Raman fiber laser. Stable dissipative soliton mode-locking was achieved with an intracavity Lyot filter formed from a length of polarization maintaining fiber and a polarization dependent optical isolator. 1.3-nJ pulses with pulse duration of 47 ps at a repetition rate of 1.77 MHz were produced. Multiple pulse operation with burst energy up to 6.7 nJ was observed at higher pump power.
Synchrotron-based X-ray Tomographic Microscopy at the Swiss Light Source for Industrial Applications (2011)

The potential of X-rays for the non-invasive investigation of the interior of bulky samples has long been recognized and their penetration depth is presently widely exploited [1 Hounsfield, G. N. 1973. Br J Radiol, 46: 1016–1022. [Crossref], [PubMed], [Web of Science ®] , [Google Scholar]]. Although initially third generation synchrotron sources were almost exclusively the realm of academic scientific experiments, the use of synchrotron light for industrial research is becoming increasingly important and relevant for both technology development and non-destructive testing, in particular when the requirements in terms of spatial, temporal, and density resolution are exceptional.