gebhart/patrepeval huggingface dataset:
Safety and Efficacy of Eculizumab in Adult aHUS Patients, With or Without Renal Transplant. (2014)

INTRODUCTION: aHUS is characterized by chronic, uncontrolled complement activation and TMA. In aHUS patients (pts), renal transplantation (RT) has previously been contraindicated due to high rates of post-RT aHUS, and consequent graft loss—by 5y post-RT, ˜50-70% of pts experienced graft loss. Eculizumab (ecu) inhibits terminal complement-mediated TMA and is proven safe and efficacious in aHUS pts regardless of RT history (hx). OBJECTIVE: Assess safety and efficacy of ecu in nontransplant (NTP) and transplant (TP) pts in the largest prospective trial of adults with aHUS. METHODS: Retrospective subanalysis of an open-label, single-arm trial to evaluate safety and efficacy of ecu in NTP and TP pts aged ≥18y. Pts were vaccinated against N. meningitidis. Inclusion criteria included platelet (plt) count <150x109/L, LDH ≥1.5xULN, and sCR ≥ULN. Primary outcomes were evaluated at 26 wk of ecu treatment (tx). RESULTS: Table 1 lists baseline (BL) characteristics and efficacy outcomes at Wk 26. There were 9 (22%) TP pts (8 had 1 prior RT; 1 had 2 prior RTs). Ecu improved plt count in both NTP (133; P<0.0001) and TP (146; P<0.0810) pts. eGFR (mL/min/1.73 m2) improved in NTP (31.5, P<0.0001) and TP (19.0, P=0.1940) pts. 66% and 56% of respective NTP and TP pts achieved CKD improvement ≥1 stage. Of NTP and TP pts who had dialysis at BL, 19/21 (90.5%) and 1/3 (33.3%) discontinued dialysis. TEAE profile was similar for both groups. CONCLUSIONS: Ecu tx resulted in clinically meaningful improvement in plt count and renal function in both NTP and TP pts. No pt progressed to ESRD requiring RT, and most pts remained dialysis-free, regardless of RT hx—consistent with subanalyses of 2 prior trials where ecu prevented progression to graft loss, and improved renal function in both NTP and TP aHUS pts. Together, these data provide additional support that ecu is a proven, effective, and safe tx in both NTP and TP aHUS pts.Table: No Caption available.DISCLOSURES:Loirat, C.: Other, Alexion Pharmaceuticals, Expert meetings fees, Alexion Pharmaceuticals, Teaching meetings fees, Alexion Pharmaceuticals, Travel honoraria, Alexion Pharmaceuticals, Coordinator for france of trials eculizumab/aHUS. Legendre, C.: Other, Alexion, Travel grant, Speaker Fees, Novartis, Speaker Fees. Ogawa, M.: Employee, Alexion Pharmaceuticals, Inc. Bedrosian, C.: Employee, Alexion. Kincaid, J.: Employee, 3Alexion Pharmaceuticals, Inc. Fakhouri, F.: Other, Alexion, Speaker Fees.
Assessment of intravenous streptokinase therapy in acute myocardial infarction. (1993)

Ten patients presenting within 6 hours of myocardial infarction, without contraindication for thrombolytic therapy, were given intravenous (IV) streptokinase (STK) 750,000 units in 15-30 min by infusion followed by anticoagulant therapy. Treatment was started within 241-360 min after the onset of symptoms. Fifteen other patients were given standard treatment without STK. Reperfusion was observed after a mean duration of 46 min in 7 patients in the STK group and none in the non-STK group. The results of IV STK thrombolytic therapy are comparable with those of previous studies using IV STK.
Chemoinformatic-guided engineering of polyketide synthases (2020)

Polyketide synthase (PKS) engineering is an attractive method to generate new molecules such as commodity, fine and specialty chemicals. A central challenge in PKS design is replacing a partially reductive module with a fully reductive module through a reductive loop exchange, thereby generating a saturated β-carbon. In this work, we sought to establish an engineering strategy for
BPC 157 Therapy and the Permanent Occlusion of the Superior Sagittal Sinus in Rat: Vascular Recruitment (2021)

We show the complex syndrome of the occluded superior sagittal sinus, brain swelling and lesions and multiple peripheral organs lesions in rat. Recovery goes centrally and peripherally, with the stable gastric pentadecapeptide BPC 157, which alleviated peripheral vascular occlusion disturbances, rapidly activating alternative bypassing pathways. Assessments were gross recording, venography, ECG, pressure, microscopy, biochemistry. The increased pressure in the superior sagittal sinus, portal and caval hypertension, aortal hypotension, arterial and venous thrombosis, severe brain swelling and lesions (cortex (cerebral, cerebellar), hypothalamus/thalamus, hippocampus), particular veins (azygos, superior mesenteric, inferior caval) dysfunction, heart dysfunction, lung congestion as acute respiratory distress syndrome, kidney disturbances, liver failure, and hemorrhagic lesions in gastrointestinal tract were all assessed. Rats received BPC 157 medication (10 µg/kg, 10 ng/kg) intraperitoneally, intragastrically, or topically to the swollen brain at 1 min ligation-time, or at 15 min, 24 h and 48 h ligation-time. BPC 157 therapy rapidly attenuates the brain swelling, rapidly eliminates the increased pressure in the ligated superior sagittal sinus and the severe portal and caval hypertension and aortal hypotension, and rapidly recruits collateral vessels, centrally ((para)sagittal venous collateral circulation) and peripherally (left superior caval vein azygos vein-inferior caval vein). In conclusion, as shown by all assessments, BPC 157 acts against the permanent occlusion of the superior sagittal sinus and syndrome (i.e., brain, heart, lung, liver, kidney, gastrointestinal lesions, thrombosis), given at 1 min, 15 min, 24 h or 48 h ligation-time. BPC 157 therapy rapidly overwhelms the permanent occlusion of the superior sagittal sinus in rat.
Dose optimization via index‐dose gradient minimization (2002)

This paper presents an iterative optimization algorithm based on gradient minimization of index dose, defined as the product of physical dose and a numerical index. Acting as a template the index distribution is designed to represent the dosimetry that meets the dose volume histogram-based optimization objectives. The treatment dosimetry is optimized when the uniformity of the index-dose distribution is maximized. Prior to optimization the user can select all or only some of the beams to be intensity modulated. The remaining unmodulated beams can be either open or wedged photon beams, electron beams, or beams of previous treatments. The optimization result and treatment delivery efficiency can often be enhanced by including not only the IM photon beams but also all suitable fixed-beams available on the linac in the treatment plan. In addition, the doses from previous treatments can also be considered in the optimization of current treatment. Five clinical examples with different complexities in optimization objective are presented. The effects of two nonoptimization variables, beam setup and initial beam weights, on the quality of the dose optimization are also presented. The results are analyzed in terms of isodose distribution, dose volume histograms, and a dose optimization quality factor. The optimization algorithm, implemented in our in-house TPS PLanUNC, has been used in clinical application since 1996. The primary advantages of our optimization algorithm include computational efficiency, intensity modulation selection choice, and performance reliability for a wide range of clinical beam setups and optimization objectives.
Development of Microstructured Reactors to Enable Organic Synthesis Rather than Subduing Chemistry (2005)

Micro-reaction technology is entering more and more into chemical process engineering and chemistry, complementing existing technologies. The benefits of microstructured reactors such as enhanced mass and heat transfer, defined residence time setting, and known, highly regular flow profiles give process intensification following standard chemical protocols. These unique features, however, can achieve more, namely to enable process chemistry with novel features. This includes handling of instable intermediates, safe processing in the explosive regime, setting reaction temperature at unusually high level, and more. In this way, the engineering benefits change the chemistry; thus, it has been termed novel chemistry here. While this has been done in a heuristic manner in the past, first deductive approaches were recently developed based on diffusion-reaction calculations and potential energy profiles which provide a mechanistic understanding what the new tool can do. In this context, many examples for organic reactions in microstructured reactors are described to underline the possible means of novel chemistry by using microstructured reactors. Keywords: microstructuring techniques, microfluidic, reactors, micro-reactor-process design, impinging-jet reactors, mechanistic chain quenching, stemming, sonogashira coupling, mizoroki-heck reaction, suzuki coupling
Could probiotics protect against human toxicity caused by polystyrene nanoplastics and microplastics? (2023)

Nanoplastics (NPs) and microplastics (MPs) made of polystyrene (PS) can be toxic to humans, especially by ingestion of plastic particles. These substances are often introduced into the gastrointestinal tract, where they can cause several adverse effects, including disturbances in intestinal flora, mutagenicity, cytotoxicity, reproductive toxicity, neurotoxicity, and exacerbated oxidative stress. Although there are widespread reports of the protective effects of probiotics on the harm caused by chemical contaminants, limited information is available on how these organisms may protect against PS toxicity in either humans or animals. The protective effects of probiotics can be seen in organs, such as the gastrointestinal tract, reproductive tract, and even the brain. It has been shown that both MPs and NPs could induce microbial dysbiosis in the gut, nose and lungs, and probiotic bacteria could be considered for both prevention and treatment. Furthermore, the improvement in gut dysbiosis and intestinal leakage after probiotics consumption may reduce inflammatory biomarkers and avoid unnecessary activation of the immune system. Herein, we show probiotics may overcome the toxicity of polystyrene nanoplastics and microplastics in humans, although some studies are required before any clinical recommendations can be made.
Piezo‐Phototronic Effect on Selective Electron or Hole Transport through Depletion Region of Vis–NIR Broadband Photodiode (2017)

Silicon underpins nearly all microelectronics today and will continue to do so for some decades to come. However, for silicon photonics, the indirect band gap of silicon and lack of adjustability severely limit its use in applications such as broadband photodiodes. Here, a high-performance p-Si/n-ZnO broadband photodiode working in a wide wavelength range from visible to near-infrared light with high sensitivity, fast response, and good stability is reported. The absorption of near-infrared wavelength light is significantly enhanced due to the nanostructured/textured top surface. The general performance of the broadband photodiodes can be further improved by the piezo-phototronic effect. The enhancement of responsivity can reach a maximum of 78% to 442 nm illumination, the linearity and saturation limit to 1060 nm light are also significantly increased by applying external strains. The photodiode is illuminated with different wavelength lights to selectively choose the photogenerated charge carriers (either electrons or holes) passing through the depletion region, to investigate the piezo-phototronic effect on electron or hole transport separately for the first time. This is essential for studying the basic principles in order to develop a full understanding about piezotronics and it also enables the development of the better performance of optoelectronics.
Optoacoustic Imaging and Tomography: Reconstruction Approaches and Outstanding Challenges in Image Performance and Quantification (2013)

This paper comprehensively reviews the emerging topic of optoacoustic imaging from the image reconstruction and quantification perspective. Optoacoustic imaging combines highly attractive features, including rich contrast and high versatility in sensing diverse biological targets, excellent spatial resolution not compromised by light scattering, and relatively low cost of implementation. Yet, living objects present a complex target for optoacoustic imaging due to the presence of a highly heterogeneous tissue background in the form of strong spatial variations of scattering and absorption. Extracting quantified information on the actual distribution of tissue chromophores and other biomarkers constitutes therefore a challenging problem. Image quantification is further compromised by some frequently-used approximated inversion formulae. In this review, the currently available optoacoustic image reconstruction and quantification approaches are assessed, including back-projection and model-based inversion algorithms, sparse signal representation, wavelet-based approaches, methods for reduction of acoustic artifacts as well as multi-spectral methods for visualization of tissue bio-markers. Applicability of the different methodologies is further analyzed in the context of real-life performance in small animal and clinical in-vivo imaging scenarios.
Asymetric C-V characteristics of graded PZT thin film capacitors (1999)

Abstract Functionally graded PZT thin films were deposited via MOD technique by varying Zr/Ti ratio in Pb(Zr,Ti)O3. Large signal C-V and small signal C-V were measured by using Symetrix Tester. They are found to be asymmetric compared to that of non-graded PZT capacitors and were gradient direction dependent. It's proposed that the built in potential due to graded polarization is the cause of the asymmetry.
Polyamic alkyl esters: versatile polyimide precursors for improved dielectric coatings (1992)

The derivatization of the pendant acid moieties along the poly(amic acid) backbone in the form of alkyl ester groups provides a unique solution to the hydrolytic instability associated with the traditional polyimide precursors and offers additional benefits in the form of increased synthetic flexibility as well as a more desirable imidization behavior. These improvements are a direct result of eliminating the monomer-polymer equilibrium associated with poly(amic acids). In the absence of hydrolytic instability, it is now possible to utilize an aqueous work-up of the polyimide precursor. This presents an attractive synthetic pathway for well-defined, amine-terminated oligomers, which can then be formulated to yield low molecular weight, chain-extendable polyimide precursors. Furthermore, the higher imidization temperatures offered by the amic alkyl ester chemistry allows for more efficient chain extension prior to imidization. The case of segmented copolyimides is also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
P2‐431: NEUROPATHOLOGY OF EARLY‐ONSET FAMILIAL ALZHEIMER'S DISEASE CAUSED BY PRESENILIN‐1 MISSENSE MUTATION THR116ASN (2019)

The majority (∼55%) of early-onset familial Alzheimer's disease (FAD) is caused by mutations in the presenilin 1 gene (PSEN1). Here we describe a family with early onset FAD with a missense mutation in thePSEN1 gene (Thr116Asn). Five family members developed dementia in the third decade of life. One subject underwent autopsy. Clinical examination, genetic analysis and CSF sampling were performed during the life. Tissue sampling and immunohistochemistry on paraffin sections were performed post mortem. The onset of clinical symptoms occurred at the age of 37 years, and the disease progressed rapidly. The clinical picture was characterized by progressive memory impairment, amnestic aphasia, and gait disturbances. Neuropathological assessment revealed widespread β-amyloid (Thal phase 5) and tau (Braak stage 6) pathology. Abundant deposition of diffuse and cored plaques were distributed in cortical and subcortical areas, as well as in the cerebellum. Cotton wool plaques were observed mainly in the occipital cortex. Cerebral amyloid angiopathy was present throughout the brain. In the neocortex, tau pathology, especially neuropil threads were more abundant in the frontal and occipital cortex and in the hippocampus. No α-synuclein or TDP-43 pathology was found in cortical or subcortical areas. Here, we present the first comprehensive neuropathological study of early-onset FAD with a missense mutation Thr116Asn in the presenilin 1 gene. In contrast to other PS1-linked AD patients, the present subject developed cotton wool plaques which were not associated with spastic paraparesis.
Al-Doped magnetite encapsulated in mesoporous carbon: a long-lasting Fenton catalyst for CWPO of phenol in a fixed-bed reactor under mild conditions (2021)

Al substituted magnetite was identified as a promising heterogeneous Fenton catalyst for CWPO of 200 ppm phenol in a continuous system under mild conditions (pH 5, 40 °C, 0.1 ml min −1 , 1.2 S H 2 O 2 ) for 500 h with 80% TOC conversion, 1 ppm Fe leaching.
Pathway‐Dependent Self‐Assembly of Perylene Diimide/Peptide Conjugates in Aqueous Medium (2011)

Most molecular self-assembly strategies involve equilibrium systems, leading to a single thermodynamic product as a result of weak, reversible non-covalent interactions. Yet, strong non-covalent interactions may result in non-equilibrium self-assembly, in which structural diversity is achieved by forming several kinetic products based on a single covalent building block. We demonstrate that well-defined amphiphilic molecular systems based on perylene diimide/peptide conjugates exhibit kinetically controlled self-assembly in aqueous medium, enabling pathway-dependent assembly sequences, in which different organic nanostructures are evolved in a stepwise manner. The self-assembly process was characterized using UV/Vis circular dichroism (CD) spectroscopy, and cryogenic transmission electron microscopy (cryo-TEM). Our findings show that pathway-controlled self-assembly may significantly broaden the methodology of non-covalent synthesis.
Multiuser decision-feedback equalization of block-spread multirate transmissions for QoS wireless networking (2002)

Multiuser decision feedback (DF) receivers can be employed to improve the bit error performance at the physical layer of wireless networks. Given a wireless network framework capable of utilizing "capacity" gains at the physical layer, DF receivers elevate the provisioned QoS guarantees. This paper develops closed-form FIR DF receivers suitable for multirate multipath transparent CDMA transmissions with block spreading codes. Capitalizing on the multiuser interference elimination capabilities of our CDMA framework, our DF receivers outperform both the linear and the successive interference canceller (SIC) receivers. Simulations illustrate the merits of our designs.
Chemical Events in Oligo(3-methoxythiophene) Coating Solutions and Their Effect on the Goldlike Coating Film Properties (2018)

Metal-free, metal-like lustrous films may find applications in a variety of fields, and a study of the factors affecting their stability is highly desirable. In particular, chemical events occurring in the coating solutions might affect the supramolecular organization of the films and therefore the metal-like luster. Herein, the chemical events occurring in acetonitrile and nitromethane coating solutions of oligo(3-methoxythiophene) and their effect on the optical properties of the films were investigated by X-ray diffraction, UV-vis absorption, and viscosity measurements. In acetonitrile, the oligomers underwent gradual dedoping with time, but only small changes in viscosity were observed. The solution was applied to a glass plate to yield a dark brown film, which turned into a goldlike lustrous film by rubbing. In nitromethane, the supramolecular structure of the oligomers changed with time from the nonaggregated state to π-dimers and then to π-stacks, and the viscosity increased. The properties of the goldlike films prepared from this solution were greatly affected by this chemical event. Remarkably, the π-dimer solution provided the film with the highest specular reflectance, yellowness, greenness, brightness, and crystallinity.
Autoantibodies detected to expressed K<sup>+</sup> channels are implicated in neuromyotonia (1997)

Antibody-mediated autoimmunity underlies a diverse range of disorders, particularly in the nervous system where the extracellular domains of ion channels and receptors are especially vulnerable targets. We present here a novel means of detecting autoantibodies where the genes of the suspected target proteins are known, and use it to detect specific autoantibodies in acquired neuromyotonia (Isaacs' syndrome), a disorder characterized by hyperexcitable motor nerves and sometimes by central abnormalities. We expressed different human brain voltage-gated potassium channels in Xenopus oocytes by injecting the relevant alpha-subunit complementary RNA, and detected antibody binding by immunohistochemistry on frozen sections. Antibodies were detected to one or more human brain voltage-gated potassium channel in 12 of 12 neuromyotonia patients and none of 18 control subjects. The results establish neuromyotonia as a new antibody-mediated channelopathy and indicate the investigative potential of this molecular immunohistochemical assay.
Is acinic cell carcinoma a variant of secretory carcinoma? A FISH study using <i>ETV6</i>‘split apart’ probes (2008)

Based on the lack of ETV6 rearrangements in ACCs, our results strongly support the concept that SCs and ACCs are distinct entities and should be recorded separately in breast cancer taxonomy schemes.
Quimioterapia adyuvante de ciclo unico postoperatorio en el cancer de mama (1986)

EL ESTUDIO ESTA REALIZADO SOBRE UN TOTAL DE 679 PAC. DE CANCER DE MAMA EN ESTADIOS I II Y II(UICC1978)PTNM. PRETENDE EL ESTUDIO DEL EFECTO SOBRE LA SUPERVIVENCIA A CINCO ANOS GLOBAL Y LIBRE DE ENFERMEDAD DE LA QUIMIOTERAPIA ADYUVANTE DE CICLO UNICO POSTOPERATORIO (C O V/A/FU) MEDIANTE CONTROL EVOLUTIVO DE CINCO ANOS DE TODAS LAS PACIENTES TRATADAS Y NO TRATADAS CON QUIMIOTERAPIA ADYUVANTE Y EN FUNCION DE ESTADIOS PTNM. SE ESTUDIA ASIMISMO LA RELACION DE ESE EFECTO SOBRE LA SUPERVIVENCIA EN FUNCION DE FACTORES CLINICOS (CLIMATERIO Y PEV) E HISTOLOGICOS (REACCION DEL ESTROMA TUMORAL HISTIOCITOSIS CROMATINA SEXUAL Y FACTORES DEL INDICE DE SCARFF-BLOOM POR SEPARADO DIFERENCIACION POLIMORFISMO Y MITOSIS).
The reward value of sucrose in leptin-deficient obese mice (2013)

Leptin-deficient patients report higher "liking" ratings for food, and leptin replacement therapy normalizes these ratings even before weight loss is achieved. Since animals cannot report their ratings, we studied the relationship between leptin and food reward in leptin-deficient ob/ob mice using a optogenetic assay that quantifies the reward value of sucrose. In this assay, mice chose between one sipper dispensing the artificial sweetener sucralose coupled to optogenetic activation of dopaminergic (DA) neurons, and another sipper dispensing sucrose. We found that the reward value of sucrose was high under a state of leptin deficiency, as well as at a dose of leptin that does not suppress food intake (12.5 ng/h). Treatment with higher doses of leptin decreased the reward value of sucrose before weight loss was achieved (100 ng/h), as seen in leptin-deficient patients. These results phenocopy in mice the behavior of leptin-deficient patients.