gebhart/patrepeval huggingface dataset:
Full-duplex communications for noise-limited systems (2018)

Full-duplex communications has become a hot area of research. A full-duplex can potentially double the amount of available spectrum, has a positive impact on the design of the protocol stack, and simplifies the design of acquisition and tracking. Most, if not all, of the recent research in this area has been focused on implementing FD for commercial terrestrial networks such as WiFi and cellular. The links in these networks are typically limited by multi-user interference and fading. To the best of the author's knowledge, very little work has been done in applying FD to noise-limited systems. A noise limited system, for the purpose of this paper, is one where additive white noise (AWGN) is the primary channel distortion. Typical examples include satellite communications (both ground to satellite and satellite to satellite) and point-to-point microwave relay links [13]. Data throughput in these systems is limited by the classical Shannon capacity - fixed available spectrum and fixed available transmit power. Both of these limitations can be due to either technical or regulatory considerations. These systems are usually `simpler' than typical multi-user networks such as WiFi and cellular. The point-to-point communications and lack of mobility motivate the use of highly directional, high gain antennas. These antennas can be either fixed (e.g. dish) or electronically steered beams (e.g. phased array). In either case, MIMO techniques are usually not applicable since the channel is trivially static (i.e. line of sight). Powerful error correction codes allow operation close to the Shannon limit. The receiver noise figure is the single most important factor in determining the link throughput. This paper presents a detailed implementation of a full-duplex receiver front end for a noise-limited system. The design trade-offs are driven by the desire to minimize the overall receiver noise figure.
High Throughput Low-Level Testosterone detection in Human Serum using a stand-alone LC-MS/MS Assay with Protein Precipitation (2023)

Abstract The use of High-Performance Liquid Chromatography-Tandem Mass Spectrometry has been pivotal to recent clinical advancements in the detection and monitoring of the progression of different metabolic disorders. Such systems have been used to routinely monitor serum testosterone levels in patients, to both mitigate side effects of different medications, as well as diagnose androgen-associated disorders. To that end, the present study develops and validates an LC-MS/MS-based assay for the detection of total serum testosterone from only (100uL) of sample volume. To further increase the highthroughput capability of the developed diagnostic kit for routine clinical use on patient samples, the proposed method was additionally streamlined via semi-automatation on a JANUS® G3 Workstation liquid handler. The proposed diagnostic kit showcased high detection precision (CV&lt;5%) as well as sample accuracy (93-108%), within a clinically relevant range of testosterone serum concentrations (5-1500ng/dl). Moreover, the assay showcased a lower limit of detection of 0.25ng/mL, which is significantly comparable to commercially established diagnostic tools. The developed method also exhibited high linearity over the specified testosterone serum range, with an obtained linearity of of R2&gt;0.99 using both manual as well as automated sample preparation. Overall, the work shown presents an optimized, automatable LC-MS/MS-based testosterone diagnostic assay for the routine evaluation of patient testosterone levels in serum for clinical and research use.
ChemInform Abstract: Correlation Between Long and Short Crack R‐Curves in Alumina Using the Crack Opening Displacement and Fracture Mechanical Weight Function Approach. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mapping a quantitative trait locus for resistance to bacterial grain rot in rice (2013)

We mapped a major QTL for BGR resistance on the long arm of chromosome 1. These results clearly demonstrated that genetic analysis of BGR resistance in rice can be effectively performed and that this trait could be a target of marker-assisted selection in rice breeding programs.
Clinical and biological activity of FLX475, an oral CCR4 antagonist, in advanced cancer. (2023)

2625 Background: FLX475 is a potent and selective CCR4 antagonist, designed to block the recruitment of immunosuppressive regulatory T cells (T reg ) into tumors without affecting healthy tissues. Blocking migration of T reg into the tumor microenvironment (TME) has the potential to restore antitumor immunity and synergize with a variety of conventional and immunotherapy-based approaches to overcome immune resistance and broaden clinical efficacy. In a recent interim clinical update from the ongoing FLX475-02 Phase 1/2 trial, evidence of monotherapy and combination activity were reported. FLX475 monotherapy induced complete responses in two of the six evaluable subjects enrolled with EBV+ NK/T cell lymphoma. In checkpoint inhibitor naïve non-small-cell lung cancer (NSCLC), 4/13 subjects (31%) had confirmed partial responses (PRs) following treatment with the combination of FLX475 and pembrolizumab. In this analysis we present biomarker data from patients with broad range of tumor types treated with FLX475 monotherapy. We provide evidence to substantiate the mechanism of action and support the combination of FLX475 with pembrolizumab. Methods: Flow cytometry was used to measure relative proportions of T reg in the periphery. CD8 and FOXP3 positive cells in tumor biopsies were quantified by immunohistochemistry (IHC).Gene set enrichment analysis and immune deconvolution methods were used to interrogate RNAseq data derived from tumor biopsies. Results: FLX475 monotherapy results in a small but significant increase in proportion of circulating CD25+CD127-/low CD4+ T reg by day 8 of treatment. IHC analysis revealed a trend towards increased CD8:FOXP3 ratio in the TME of patient biopsies. Transcriptomic profiles from tumor biopsies of FLX475 monotherapy treated patients exhibited significant changes in immune pathways likely to benefit the antitumor response. Using global gene expression analyses we identified that FLX475 monotherapy altered the transcriptome of tumors to resemble those from patients with favorable clinical outcome to anti-PD(L)-1 treatment. Consistent with the proposed mechanism of action, immune deconvolution identified that FLX475-treated patients experienced a decrease in T reg cell populations. Conclusions: FLX475 monotherapy results in beneficial changes in the TME consistent with our proposed mechanism of action. FLX475 monotherapy is modifying the tumor microenvironment toward a phenotype associated with response to anti-PD-1/anti-PD-L1. Clinical trial information: NCT03674567 .
Supplementary Information from Eribulin Plus Pembrolizumab in Patients with Metastatic Triple-Negative Breast Cancer (ENHANCE 1): A Phase Ib/II Study (2023)

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Synthesis of High Enantiopurity N-Protected α-Amino Ketones by Thiol Ester−Organostannane Cross-Coupling Using pH-Neutral Conditions (2008)

An efficient synthesis of high enantiopurity N-protected alpha-amino ketones is described. Complementing other studies using boronic acids and thiol esters, this Cu(I) diphenylphosphinate (CuDPP)-mediated, palladium-catalyzed coupling of alpha-amino thiol esters with aryl, heteroaryl, allyl, and alkenyl organostannanes gives N-protected alpha-amino ketones in high yields with high enantiopurity (in almost all cases) under mild and pH-neutral reaction conditions. The viability of pi-deficient heteroarylstannanes is an advantage of this reaction compared to the related boronic acid system.
Tax-Smart Portfolio Valuation and Performance Measurement (2021)

The reported performance of a portfolio is consequential for both investors and managers. One component of the return calculation is the beginning and ending value of the portfolio. The standard in the industry is to calculate portfolio values from the market prices of the constituent securities. Assuming the portfolio can be liquidated at these prices, in the absence of tax considerations, the market value accurately represents the true value of the portfolio, and therefore, the resulting measure of performance is uncontroversial. But what if the portfolio is taxable? Neither the market value nor the liquidation value accurately represents the true worth of a taxable portfolio. However, accurate values are essential to calculating the performance of mutual funds, exchange-traded funds, and separately managed accounts. This is especially true for tax-exempt municipal bond portfolios—interest is tax-free, but capital gains are taxable. The author explores three alternatives to pretax value: liquidation value, hold value, and the larger of these two, defined as tax-smart value. The author recommends the tax-smart value to measure the performance of an actively managed portfolio. <b>TOPICS:</b>Portfolio construction, legal/regulatory/public policy, mutual funds/passive investing/indexing, fixed income and structured finance <b>Key Findings</b> ▪ Pretax portfolio value is inappropriate for measuring the true performance of a taxable portfolio. ▪ For actively managed portfolios, we recommend using tax-smart value, which is the greater of after-tax liquidation value and hold value. ▪ For buy-and-hold portfolios, hold value is recommended. ▪ The calculation of the hold value of a tax-exempt bond requires tax-neutral option-adjusted spread analytics.
All-flavour search for neutrinos from dark matter annihilations in the Milky Way with IceCube/DeepCore (2016)

We present the first IceCube search for a signal of dark matter annihilations in the Milky Way using all-flavour neutrino-induced particle cascades. The analysis focuses on the DeepCore sub-detector of IceCube, and uses the surrounding IceCube strings as a veto region in order to select starting events in the DeepCore volume. We use 329 live-days of data from IceCube operating in its 86-string configuration during 2011–2012. No neutrino excess is found, the final result being compatible with the background-only hypothesis. From this null result, we derive upper limits on the velocity-averaged self-annihilation cross-section, $$\langle \sigma _A \mathrm{v} \rangle $$ , for dark matter candidate masses ranging from 30 GeV up to 10 TeV, assuming both a cuspy and a flat-cored dark matter halo profile. For dark matter masses between 200 GeV and 10 TeV, the results improve on all previous IceCube results on $$\langle \sigma _A \mathrm{v} \rangle $$ , reaching a level of 10 $$^{-23}$$ cm $$^3$$ s $$^{-1}$$ , depending on the annihilation channel assumed, for a cusped NFW profile. The analysis demonstrates that all-flavour searches are competitive with muon channel searches despite the intrinsically worse angular resolution of cascades compared to muon tracks in IceCube.
Photomechanical molecular crystals and nanowire assemblies based on the [2+2] photodimerization of a phenylbutadiene derivative (2020)

Crystalline (<italic>E</italic>)-4-fluoro-cinnamaldehyde malononitrile undergoes a [2+2] photocycloaddition, leading to a robust photomechanical response and improved force generation by nanowire ceramic composites.
Multiple Domains of Tetanus Toxin Direct Entry into Primary Neurons (2014)

Tetanus toxin elicits spastic paralysis by cleaving VAMP-2 to inhibit neurotransmitter release in inhibitory neurons of the central nervous system. As the retrograde transport of tetanus neurotoxin (TeNT) from endosomes has been described, the initial steps that define how TeNT initiates trafficking to the retrograde system are undefined. This study examines TeNT entry into primary cultured cortical neurons by total internal reflection fluorescence (TIRF) microscopy. The initial association of TeNT with the plasma membrane was dependent upon ganglioside binding, but segregated from synaptophysin1 (Syp1), a synaptic vesicle (SV) protein. TeNT entry was unaffected by membrane depolarization and independent of SV cycling, whereas entry of the receptor-binding domain of TeNT (HCR/T) was stimulated by membrane depolarization and inhibited by blocking SV cycling. Measurement of the incidence of colocalization showed that TeNT segregated from Syp1, whereas HCR/T colocalized with Syp1. These studies show that while the HCR defines the initial association of TeNT with the cell membrane, regions outside the HCR define how TeNT enters neurons independent of SV cycling. This provides a basis for the unique entry of botulinum toxin and tetanus toxin into neurons.
PEG-Poly(amino acid)s/MicroRNA Complex Nanoparticles Effectively Arrest the Growth and Metastasis of Colorectal Cancer (2016)

One of the biggest challenges in developing microRNA (miRNA) based therapeutics is the method of delivery. Herein we report the design and synthesis of mPEG-poly(amino acid)s, which we used as a novel nanocarrier for the delivery of miRNA-139-5p. The PEG-poly(amino acid)s/miRNA-139-5p nanoparticle complex is more effective at suppressing tumor growth and migration in mice with colorectal cancer than when treated with miRNA-139-5p solution and blank nanoparticles individually. Our results suggest that PEG-poly(amino acid)s are a promising non-viral gene vector for the delivery of miRNAs to treat cancers.
Formation Mechanism of Guided Resonances and Bound States in the Continuum in Photonic Crystal Slabs (2016)

We develop a formalism, based on the mode expansion method, to describe the guided resonances and bound states in the continuum (BICs) in photonic crystal slabs with one-dimensional periodicity. This approach provides analytic insights to the formation mechanisms of these states: the guided resonances arise from the transverse Fabry-Pérot condition, and the divergence of the resonance lifetimes at the BICs is explained by a destructive interference of radiation from different propagating components inside the slab. We show BICs at the center and on the edge of the Brillouin zone protected by symmetry, as well as BICs at generic wave vectors not protected by symmetry.
Ab Initio Molecular Dynamics Study of Metallocene-Catalyzed Ethylene Polymerization (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAb Initio Molecular Dynamics Study of Metallocene-Catalyzed Ethylene PolymerizationRobert J. Meier, Gerard H. J. van Doremaele, Simonetta Iarlori, and Francesco BudaCite this: J. Am. Chem. Soc. 1994, 116, 16, 7274–7281Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00095a034https://doi.org/10.1021/ja00095a034research-articleACS PublicationsRequest reuse permissionsArticle Views309Altmetric-Citations106LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Human computer interaction via the human hand: a hand model (2002)

A new method for building lifelike hand models which articulate in a realistic manner is presented. This method has distinct benefits over previous methods, since the fitting to a particular person's hand is quick, simple and very accurate. Following the calibration process which fits it to a particular person's hand, this hand model can be used in numerous HCI scenarios. Calibration is based on anatomical studies of the human hand and on the specific method of recognition to be employed in the HCI scenarios. The calibration method is done visually and requires only three views of the hand to be modeled. The calibration system is designed to be accurate, to be easy to use and to allow for a short calibration time. These characteristics are all desirable when one is working in the realm of a human computer interfacing.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Electric field induced reversible 180° magnetization switching through tuning of interfacial exchange bias along magnetic easy-axis in multiferroic laminates (2015)

E-field control of interfacial exchange coupling and deterministic switching of magnetization have been demonstrated in two sets of ferromagnetic(FM)/antiferromagnetic(AFM)/ferroelectric(FE) multiferroic heterostructures, including NiFe/NiCoO/glass/PZN-PT (011) and NiFe/FeMn/glass/PZN-PT (011). We designed this experiment to achieve exchange bias tuning along the magnetic easy axis, which is critical for realizing reversible 180° magnetization deterministic switching at zero or small magnetic bias. Strong exchange coupling were established across AFM-FM interfaces, which plays an important role in voltage control of magnetization switching. Through the competition between the E-field induced uniaxial anisotropy in ferromagnetic layer and unidirectional anisotropy in antiferromagnetic layer, the exchange bias was significantly shifted by up to |∆Hex|/Hex = 8% in NiFe/FeMn/glass/PZN-PT (011) and 13% in NiFe/NiCoO/glass/PZN-PT (011). In addition, the square shape of the hysteresis loop, as well as a strong shape tunability of |∆Hex|/Hc = 67.5 ~ 125% in NiFe/FeMn/glass/PZN-PT and 30 ~ 38% in NiFe/NiCoO/glass/PZN-PT were achieved, which lead to a near 180° magnetization switching. Electrical tuning of interfacial exchange coupling in FM/AFM/FE systems paves a new way for realizing magnetoelectric random access memories and other memory technologies.
New mesogenic maleimide-styrene copolymers via N-oxyl mediated free radical copolymerization (2003)

New mesogenic N-substituted maleimide monomer was obtained starting 4-maleimido benzoic acid, hydroquinone and hexadecyloxy benzoic acid by successive Schotten-Bauman condensations.The copolymerization of this monomer in 1 : 1 ratio with styrene was performed both by stable free radical polymerization (SFRP) and conventional free radical polymerization (CFRP).High molecular weight polymeric material in high conversion and with low polydispersity was obtained under SFRP conditions.By using 1 H-and 13 C-NMR techniques, structural characteristics of the polymers were evidenced that could sustain the alternating character of the copolymers and the participationof the electron donor-acceptor complex in the propagation step.The copolymers formed a liquid crystal mesophase in the melt.This was ascribed to the strong tendency of the rod-like side groups on the stiff imide ring to order even in 1 : 1 dilute systems such as the alternating copolymers.
Small-Molecule Suppressors of <i>Candida albicans</i> Biofilm Formation Synergistically Enhance the Antifungal Activity of Amphotericin B against Clinical <i>Candida</i> Isolates (2013)

A new class of fungal biofilm inhibitors represented by shearinines D (3) and E (4) were obtained from a Penicillium sp. isolate. The inhibitory activities of 3 and 4 were characterized using a new imaging flow-cytometer technique, which enabled the rapid phenotypic analysis of Candida albicans cell types (budding yeast cells, germ tube cells, pseudohyphae, and hyphae) in biofilm populations. The results were confirmed by experimental data obtained from three-dimensional confocal laser scanning microscopy and 2,3-bis(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium-5-carboxanilide (XTT) assays. These data indicate that 3 and 4 inhibited C. albicans biofilm formation by blocking the outgrowth of hyphae at a relatively late stage of biofilm development (IC50 = 8.5 and 7.6 μM, respectively). However, 3 and 4 demonstrated comparatively weak activity at disrupting existing biofilms. Compounds 3 and 4 also exhibited synergistic activities with amphotericin B against C. albicans and other clinical Candida isolates by enhancing the potency of amphotericin B up to 8-fold against cells in both developing and established biofilms. These data suggest that the Candida biofilm disruption and amphotericin B potentiating effects of 3 and 4 could be mediated through multiple biological targets. The shearinines are good tools for testing the potential advantages of using adjunctive therapies in combination with antifungals.
Instrumentation to Support the Research Program of Pulsed Laser Deposition of Polymer Nanocomposite Films (2015)

Abstract : This supported grant was very great to compliment the current grant which is conducting research project Laser deposition of polymer nanocomposite films sponsored by AFOSR through research Grants FA9550-12-1-0068. The five-year project is entering its fourth year and without the support of this grant, much work would be delayed and would be even impossible to achieve. The main objective of the project is to investigate feasibility of the new method of pulsed laser deposition (PLD) invented by Dr. Darwish, which is called multiple beam pulsed laser deposition (MPLD). It is expected that the method will be especially beneficial for making polymer/inorganic nanocomposite films, which conventional PLD methods fail to produce. It has been already demonstrated for the first time that the proposed new MPLD made possible to transfer the highly efficient inorganic upconversion rare earth (RE) fluoride phosphors in composite polymer films preserving the RE compound crystalline structure and high-brilliance upconversion emission. This is due to much better control of the deposition process of the materials of different nature. In order to extend greatly the capabilities of the ongoing DoD funded research program, grant supported to acquire the needed instrumentation to support the acquiring the data and optical characterization of the fabricated thin film by the DPLD chamber: Here is the list of the equipment which was purchased and installed in the optical characterization lab which is adjacent to the PLD lab.