gebhart/patrepeval huggingface dataset:
MDS overlap disorders and diagnostic boundaries (2019)

Myelodysplastic syndromes (MDS) are clonal diseases defined by clinical, morphologic, and genetic features often shared by related myeloid disorders. The diagnostic boundaries between these diseases can be arbitrary and not necessarily reflective of underlying disease biology or outcomes. In practice, measures that distinguish MDS from related disorders may be difficult to quantify and can vary as disease progression occurs. Patients may harbor findings that are not consistent with a single diagnostic category. Several overlap disorders have been formally described, such as the myelodysplastic/myeloproliferative neoplasms (MDS/MPNs). These disorders are characterized by hematopoietic dysplasia with increased proliferation of monocytes, neutrophils, or platelets. They may have mutational profiles that distinguish them from the disorders they resemble and reflect important differences in pathophysiology. MDS also shares diagnostic borders with other diseases. For example, aplastic anemia and hypoplastic MDS can be difficult to distinguish in patients with pancytopenia and bone marrow hypocellularity. Genetic features may help in this regard, because they can identify differences in prognosis and risk of progression. The boundary between MDS and secondary acute myeloid leukemia (sAML) is arbitrarily defined and has been redefined over the years. Genetic studies have demonstrated that sAML clones can precede clinical progression from MDS by many months, suggesting that MDS with excess blasts could be viewed as an overlap between a dysplastic bone marrow failure syndrome and an oligoblastic leukemia. This review will describe the diagnostic boundaries between MDS, MDS/MPNs, sAML, clonal hematopoiesis of indeterminate potential, clonal cytopenia of undetermined significance, and aplastic anemia and how genetic approaches may help to better define them.
Performance issues in CRMA networks for integrated broadband communications (1992)

The capabilities of the cyclic reservation multiple access (CRMA) protocol for supporting mixed video and data traffic was evaluated by computer simulation. The results show that in order to obtain good performance and fairness between all the mixed stations, they should have similar requirements in terms of the number of slots that are requested at each reservation cycle. It is therefore important to reduce the variability by aggregating more slots for stations with short packets, and by transmitting long frames in successive cycles for long packets. The optimal selection of the low and high bound on the number of slots can significantly improve the performance of the CRMA network under mixed traffic conditions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
The Efficacy of Cigarette Warning Labels on Health Beliefs in the United States and Mexico (2013)

Concern over health risks is the most common motivation for quitting smoking. Health warnings on tobacco packages are among the most prominent interventions to convey the health risks of smoking. Face-to-face surveys were conducted in Mexico (n = 1,072), and a web-based survey was conducted in the US (n = 1,449) to examine the efficacy of health warning labels on health beliefs. Respondents were randomly assigned to view two sets of health warnings (each with one text-only warning and 5-6 pictorial warnings) for two different health effects. Respondents were asked whether they believed smoking caused 12 different health effects. Overall, the findings indicate high levels of health knowledge in both countries for some health effects, although significant knowledge gaps remained; for example, less than half of respondents agreed that smoking causes impotence and less than one third agreed that smoking causes gangrene. Mexican respondents endorsed a greater number of correct beliefs about the health effects of smoking than did the U.S. sample. In both countries, viewing related health warning labels increased beliefs about the health risks of smoking, particularly for less well-known health effects such as gangrene, impotence, and stroke.
ACF7 regulates inflammatory colitis and intestinal wound response by orchestrating tight junction dynamics (2017)

In the intestinal epithelium, the aberrant regulation of cell/cell junctions leads to intestinal barrier defects, which may promote the onset and enhance the severity of inflammatory bowel disease (IBD). However, it remains unclear how the coordinated behaviour of cytoskeletal network may contribute to cell junctional dynamics. In this report, we identified ACF7, a crosslinker of microtubules and F-actin, as an essential player in this process. Loss of ACF7 leads to aberrant microtubule organization, tight junction stabilization and impaired wound closure in vitro. With the mouse genetics approach, we show that ablation of ACF7 inhibits intestinal wound healing and greatly increases susceptibility to experimental colitis in mice. ACF7 level is also correlated with development and progression of ulcerative colitis (UC) in human patients. Together, our results reveal an important molecular mechanism whereby coordinated cytoskeletal dynamics contributes to cell adhesion regulation during intestinal wound repair and the development of IBD.
Beamfield analysis for statistically described planar microphone arrays (2009)

An analysis of Delay and Sum beamforming using microphone arrays with two-dimensional stochastic geometry in an office environment is carried out with two metrics proposed to rate the performance of these arrays: main lobe width (MLW) and peak-to-sidelobe ratio (PSR). Geometries with irregular microphone placements use a dispersion measure analogous to aperture and centroid to indicate array center relative to focal point. Sets of stochastic arrays are generated though Monte Carlo simulations and their performance is evaluated using the proposed metrics for varying number of microphones, sound source frequency, centroid location, and dispersion and compared to rectangular arrays. Performance results show increasing the number of microphones in a stochastic geometry increases the average PSR by 3 dB per doubling of microphones but remains one standard deviation below regular array performance while MLW remains relatively constant and close to that of the regular arrays. Increasing target frequency reduced MLW for both stochastic and regular geometries. Both types of arrays lost PSR while regular arrays were 5-10 dB superior. For increasing centroid displacement regular arrays display similar or inferior performance in PSR by as much as 5 dB versus the random arrays and mostly similar performance in MLW. Increasing the array dispersion reduces both the MLW and PSR, where the MLW for the stochastic geometries is on par with the corresponding regular geometries and the PSR is on the order of 5 to 10 dB below the regular arrays.
3.8 A 0.45-to-0.7V 1-to-6Gb/S 0.29-to-0.58pJ/b source-synchronous transceiver using automatic phase calibration in 65nm CMOS (2015)

Supply voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> ) scaling offers a means to greatly reduce power in serial link transceivers. Ideally, power efficiency at a given data rate can be improved by reducing V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> while increasing the number of multiplexed circuits operating in parallel at lower clock frequencies [1]. Though increasing the amount of parallelism is desirable to scale V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> , in practice, it is limited by two main factors. First, increased sensitivity to device variations (threshold voltage/dimension mismatch) at lower V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> makes it extremely challenging to generate equally spaced multi-phase clocks needed in multiplexed transmitter and receiver. Phase calibration methods can correct phase-spacing errors [2,3], but their effectiveness at lower V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> is limited as the calibration circuits themselves become sensitive to device variations. Second, as oscillator output swing reduces with V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> , its phase noise degrades, making low-noise clock generation difficult to implement with low power dissipation. Phase noise can be suppressed by embedding the oscillator in a wide bandwidth analog phase-locked loop (APLL), but conventional charge-pump-based APLLs are difficult to design at low supply voltages (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> <;0.5V). Digital PLLs (DPLLs) can operate at low V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> , but they suffer from conflicting noise bandwidth tradeoffs, which prevent increasing the bandwidth to suppress oscillator phase noise adequately. In this paper, we present a phase-calibration method that enables the operation of a source-synchronous transceiver down to V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> of 0.45V. The energy efficiency and data-rate of the prototype transceiver scale from 0.29 to 0.58pJ/b and 1.3Gb/s to 6Gb/s, respectively, as V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">DD</sub> is varied from 0.45 to 0.7V.
Risk of symptomatic central nervous system (CNS) progression and secondary hemorrhage in patients with non-squamous non-small cell lung cancer (NSCLC) receiving bevacizumab (BV)-based first-line therapy (2008)

8114 Background: Preliminary data on the safety of Bv in subjects with advanced or metastatic NSCLC with previously treated brain metastases due to NSCLC revealed no CNS hemorrhagic events (Akerley, IASLC 2007). This preliminary safety report investigates the occurrence of NSCLC progression and CNS hemorrhage among patients receiving Bv. Methods: E4599 and AVAiL are randomized, phase III studies combining Bv with carboplatin/paclitaxel (CP) and cisplatin/gemcitabine (CG), respectively, in the first-line treatment of non- squamous NSCLC. As the presence of CNS metastases rendered a subject ineligible, both studies required baseline imaging of the CNS and as clinically indicated thereafter. In both studies, Bv was continued until disease progression or unacceptable toxicity (including Grade ≥3 hemorrhage and Grade ≥2 non-pulmonary hemorrhage in E4599 and AVAiL, respectively). Results: See Table. Conclusions: Among treated subjects with documented CNS progression, Bv does not appear to increase the risk of CNS hemorrhage compared to controls. In AVAiL, CNS progression is less frequent in subjects treated with Bv in this series. E4599 AVAiL CP CP + Bv 15 mg/kg CG CG + Bv 7.5 mg/kg CG + Bv 15 mg/kg N 441 427 327 330 329 Progression Event in CNS n (%) 14 (3.2) 13 (3.0) 12 (3.7) 7 (2.1) 4 (1.2) CNS hemorrhages in treated patients with documented CNS progression event 0 1 0 0 0 CNS hemorrhages, in all treated patients (with and without CNS progression) 1 3 2 2 1 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Genentech™ BioOncology, Roche Boehringer Ingelheim, Eli Lilly, Genentech™ BioOncology, Idera, Merck, Roche, Taiho Genentech™ BioOncology Bayer, Boehringer Ingelheim, Eli Lilly, Genentech™ BioOncology, Roche Genentech™ BioOncology
Table S5 from T-Cell Deletion of MyD88 Connects IL17 and IκBζ to RAS Oncogenesis (2023)

&lt;p&gt;Primers used for mouse colonies genotyping.&lt;/p&gt;
Sophisticating business performance management for banks: using data envelopment analysis on business process level (2012)

Crucial bank inefficiencies are rooted in the bank’s production processes. From an operations perspective, the assessment of inefficiencies, especially in highly standardised processes, should lead to better directed action for improvement and hence efficiency enhancement. This paper presents a new application of DEA for the measurement of business process efficiency. In our case study, the efficiency of the securities settlement and clearing process of a large European bank is analysed. It is a unique, large-scale dataset containing actual production data of this bank. Two different input-output models are used, representing most important objectives of operations managers in process performance analysis. The results show a high variance in process performance among different perspectives of analysis, indicating production inefficiencies in the process execution.
Mean Pressure Gradient Prediction Based on Chest Angular Movements and Heart Rate Variability Parameters (2021)

This study presents our recent findings on the classification of mean pressure gradient using angular chest movements in aortic stenosis (AS) patients. Currently, the severity of aortic stenosis is measured using ultra-sound echocardiography, which is an expensive technology. The proposed framework motivates the use of low-cost wearable sensors, and is based on feature extraction from gyroscopic readings. The feature space consists of the cardiac timing intervals as well as heart rate variability (HRV) parameters to determine the severity of disease. State-of-the-art machine learning (ML) methods are employed to classify the severity levels into mild, moderate, and severe. The best performance is achieved by the Light Gradient-Boosted Machine (Light GBM) with an F1-score of 94.29% and an accuracy of 94.44%. Additionally, game theory-based analyses are employed to examine the top features along with their average impacts on the severity level. It is demonstrated that the isovolumetric contraction time (IVCT) and isovolumetric relaxation time (IVRT) are the most representative features for AS severity.Clinical Relevance- The proposed framework could be an appropriate low-cost alternative to ultra-sound echocardiography, which is a costly method.
Exploring the social Internet of Things concept in a univeristy campus using NFC (2015)

The use of characteristics of smart objects that have interactions features with humans, gave rise to the Internet of Things (IoT). Numerous derivations from this concept have been proposed. In this article, we focus on one of those called Social Internet of Things (SIoT). SIoT prioritizes the relationship between smart objects, where the objects can establish a connection among themselves without the interference of their owners. The purpose of this article is to explore the concept of SIoT in a University Campus, offering direct communication between intelligent devices. These devices share information based on an academic criteria and preferences informed by their owners. To evaluate the proposal, we developed a case study. The preliminary results show the viability of the proposal.
A novel scheme for better performance in optical code-division multiple access (2006)

A new spectra-interleaved scheme for passive optical fast frequency-hopped code-division multiple access system is proposed. Interference and bit error rate are improved by numerical result with this new scheme.
Response to the Comments of Drs. Gahbauer and Young (1996)

well as pharmacokinetics and drug distribution make the design of appropriate animal models a formidable and perhaps insurmountable challenge. We would interpret the data in this paper as indicating that all data points favor fractionated BNCT even though the variables as chosen were biased against this result. One may use these data to d sign future experiments, but any conclusions drawn from them regarding this important aspect of BNCT would certainly be premature.
Genetic and biochemical characterization of human lymphocyte cell surface antigens. The A-1A5 and A-3A4 determinants. (1984)

The genes that code for the human lymphocyte cell surface determinants defined by monoclonal antibodies A- 1A5 and A- 3A4 have been genetically mapped. All human chromosomes, except Y, were included in a series of human less than mouse lymphocyte hybrid populations that retained expression of lymphocyte-specific surface markers. Expression of the A- 1A5 and A- 3A4 antigens was quantitated by indirect immunofluorescence and fluorescence-activated cell sorter (FACS) analysis. Hybrid populations heterogeneous for antigen expression were sorted to yield antigenically homogeneous subpopulations. Isozyme analysis indicated concordant segregation of the A- 1A5 determinant with chromosome 10, and the A- 3A4 determinant with chromosome 4. In contrast to the unhybridized human parent cell line (MOLT-4), from which A- 1A5 immunoprecipitated two proteins (160,000 and 125,000 Mr), A- 1A5 only immunoprecipitated a single band (125,000 Mr) from an A- 1A5 -expressing human less than mouse hybrid. The genetic disassociation of these two proteins from the A- 1A5 -reactive complex suggests that the appearance of the 160,000 Mr protein requires a gene locus that is unlinked to the locus for the 125,000 Mr protein on chromosome 10. A third component of the A- 1A5 -reactive protein complex (210,000 Mr), which is recognized by the monoclonal antibody TS2/7, was not expressed on the parent MOLT-4 cells, but was weakly expressed on MOLT-4 less than mouse BW5147 hybrids. This allowed preliminary mapping of that determinant to either chromosome 10 or 15. The A- 3A4 antigen (approximately 45,000 Mr) is a novel cell surface structure expressed on all hematopoietic cell lines tested, and represents the first cell surface marker mapped to chromosome 4.
Bidirectional current-fed converter for integration of dc micro-grid with ac grid (2011)

Most of the loads found in various commercial installations require front end ac-dc conversion. Various storage systems and renewable sources interact with these loads and the ac grid through dc-ac converters. These multistage conversions reduce system efficiency. To avoid this, an ac distribution system can be replaced by a dc distribution system within a commercial facility. It results in improved system efficiency and reliability. This paper proposes a three-phase current-fed converter, interfacing a dc distribution system with a utility ac grid. It has bidirectional power flow capability. The converter injects or draws low ripple current from a dc micro-grid, while maintaining high power factor and low current distortion on ac grid side. It has improved reliability and size over conventional VSC. The steady state and dynamic performance of the converter is studied using MATLAB Simulink. The converter also has a limited capacity of supplying or absorbing reactive power. These limits are computed for both inversion and rectification modes of operation.
Nazi War Crimes, US Intelligence and Selective Prosecution at Nuremberg (2007)

Reviewing recently declassified CIA documents, this book provides a balanced but critical discussion of the contribution of American intelligence officials to the Nuremberg war crimes trials. Giving new details of how senior Nazi war criminals, such as SS General Karl Wolff, were provided with effective immunity deals, partly as a reward for their wartime cooperation with US intelligence officials, including Allen Dulles, former CIA Director, the author also discusses the role of such officials in mobilizing the unique resources of a modern intelligence agency to provide important trial testimony and vital documentary evidence. Nazi War Crimes, US Intelligence and Selective Prosecution at Nuremberg argues that both war crimes prosecutors and intelligence officials can engage in mutually beneficial collaborations, but that both sides need to recognize and appreciate the problems that may arise from the fact that these institutions are required to operate according to different, and in some cases contradictory, agendas. This topical book gives those studying, or with interests in, international law, criminal law and history an insight into the debates surrounding international war crimes, within the context of the Nuremberg war crimes trials.
Combining JBCA and Marfey's methodology to determine the absolute configuration of threonines: the case of gunungamide A, a new cyclic depsipeptide containing chloropyrrole from the sponge <i>Discodermia</i> sp. (2018)

JBCA and Marfey's allowed us to distinguish threonines diasteroisomers.
Structure Activity Relationship in the Colchicine Molecule with Respect to Interaction with the Mammalian Multidrug Transporter, P-Glycoprotein (1994)

Colchicine forms part of a p u p of structurally unrelated cytotoxic drugs to which P-glycoprotein overexpression confers resistance to, both in cultured cells i n vi t rod tumor cells i n .Modifications of the methoxy groups on the A and C rings modulated cellular toxicity but had no effect on P-gp interaction.Modi fi cat i ons at the C7 position of the B-ring, in particular the removal of the nitrogen atom of the acetamido group, had a dramatic effect.Examination of calculated molar refractivities (CMR) revealed that only compoundsshowing CMR values greater than 9.7 were P-gp substrates, suggesting a minimal size requirement for efficient interaction with Pgp.
NMR study on colloidal magnetic fluids of various viscosities (2004)

NMR experiments on mobile spins in the liquid continuous phase of a magnetic fluid are applied to characterize the particle arrangement and to study self diffusion of the fluid medium. It is observed that the resonance frequencies and line shapes depend on the particle concentration, particle magnetization, particle agglomeration and on the sample geometry. A controlled variation of the self diffusion constant is performed either by addition of macromolecules to or by adjusting the sample temperature. The influence of the solvent viscosity on the NMR line shape is analyzed by numerical simulation of the spectra. The method presents a valuable tool for the observation of changes in dispersion structure or molecular mobility, e.g., during phase transitions.
Dielectrophoretic Deposition of Graphite Oxide Soot Particles (2008)

Alternating current dielectrophoresis in water was used to position graphite oxide soot (GO-soot) particles generated by rapid thermal expansion of graphite oxide under inert gas. The dielectrophoretic deposition was carried out at a frequency of 10 MHz and a peak-to-peak voltage of 10 V, and the deposited particles were analyzed using scanning electron microscopy. The vertical cross section, obtained by focused ion beam cutting, shows the wrinkled layers of the GO-soot particles and cavities between the layers. The electrical transport measurements show typical characteristics of metal-like pathways. The improved electrical contact between electrodes and GO-soot, probably due to the thin platelet structure of GO-soot, makes the material favorable for electrical device applications. The results demonstrate that AC dielectrophoresis can be used to selectively deposit graphite oxide soot particles at desired locations.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Roserine. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cardiac Overexpression of PDE4B Blunts β-Adrenergic Response and Maladaptive Remodeling in Heart Failure (2020)

Our results indicate that a moderate increase in PDE4B is cardioprotective and suggest that cardiac gene therapy with PDE4B might constitute a new promising approach to treat heart failure.
ChemInform Abstract: ORGANOTIN NUCLEOPHILES. 5. PALLADIUM‐CATALYZED ALLYLIC PROPARGYLATION WITH ALLENYLSTANNANE (1984)

Abstract Tributyl‐allenyl‐zinn (II) kann zur Einführung von Propargylresten in Allyl‐acetate unter Zusatz von Pd‐Katalysatoren dienen.