gebhart/patrepeval huggingface dataset:
Addition of All-Trans Retinoic Acid (ATRA) to the Combination of Fludarabine, Cytarabine, Idarubicin, with or without GCSF in Older, Higher Risk Patients with AML and High-Risk MDS Does Not Improve the Outcome in Those with NPM1 Mutation. (2012)

Abstract Abstract 2616 Background: Previous studies have been conflicting in their findings regarding whether NPM1 gene mutations may be a marker for response to all-trans retinoic acid (ATRA) given as an adjunct to intensive chemotherapy in patients with acute myeloid leukemia (AML) (Schlenk RF, Haematologica, 2009, 94, 54–60, Burnett AK, Blood, 2010, 115,948, and Schlenk RF, abstract #80, ASH 2011). Patients and Methods: we examined the impact of the addition of ATRA among patients with diploid cytogenetics treated on a randomized phase II study of fludarabine + cytarabine + idarubicine +/− GCSF +/− ATRA with available data on their NPM1 mutation status. Between September 1995 and November 1997, 215 patients with newly diagnosed AML (n=153) or high-risk MDS (RAEB or RAEB-T; n=62) were enrolled in the study. They had to have one of the unfavorable features of age &gt; 71 years, antecedent hematological disorder (AHD), therapy- related disease, or high bilirubin (&gt;2.9 mg/ml) or creatinine (&gt;1.5 mg/ml) to be eligible to participate in the study (Estey E, Blood, 1999, 93, 2478). Among them 70 patients had diploid cytogenetic and are the subjects of this analysis. Results: The median age of the 70 patients was 66.5 (range, 23–87), 60% had AHD, 15.7% had therapy-related disease, and 40% were older than 71. Bone marrow samples were available for all patients for examination by immunohistochemistry (IHC) for the presence of cytoplasmic NPM (correlating to NPM1 mutation). Twenty (29%) of patients had NPM1 mutation. Among them 7 (35%) did and 13 (65%) did not receive ATRA in combination with chemotherapy. Complete remission (CR) was achieved in 5 (71.4%) of patients treated with ATRA as compared to 9 (69.2%) without ATRA (p=NS). The median event-free survival was 82 weeks vs. 56 weeks for patients receiving ATRA or not [(p=0.5), ranges, (10–173 weeks) and (1–646 weeks), respectively]. The median overall survival was 41 weeks vs. 60 weeks for patients receiving ATRA or not [(p=0.74), ranges, (3–452 weeks) and (0–735 weeks), respectively]. Conclusion: There was no significant difference in CR rate, EFS, or OS in this higher risk population of patients with NPM1 mutated diploid AML or high-risk MDS receiving ATRA as an adjunct to chemotherapy. Disclosures: Kantarjian: Genzyme: Research Funding. Ravandi:genzyme: Research Funding.
Design optimization of switched reluctance machine using genetic algorithm (2015)

This paper studies a design optimization procedure for switched reluctance motors (SRMs) using a Genetic Algorithm (GA). A multi-objective optimization method has been employed in the optimization of current commutation angles for priority operating points and over the entire operating range of the machine. Criteria of optimal control, which are maximizing output average torque and minimizing the root mean square value of net torque ripple, have been used in the optimization problem. A decision-making algorithm has been investigated to choose a solution from the optimal Pareto-front with finite optimal points. Five SRM design candidates have been selected and studied. The optimized motor performance at the priority operating points has been used to compare between different designs. Finally, a motor design that satisfies all design requirements has been characterized over its entire operating envelope based on turn-on and turn-off angles.
Echopattern parameter as an aid to profile Crohn's disease patients (2023)

The characterization of bowel wall echopattern allows for the identification of different CD behaviors.
Human Cerebral Malaria (1987)

The following report using light and electron microscopic and immunological techniques is based on a series of 19 Burmese patients who died of cerebral malaria. The principal change was blockage of cerebral capillaries by Plasmodium falciparum-infected erythrocytes. Ring hemorrhages and segmental necrosis of cerebral capillaries were common. Cerebral edema was variable in these cases. Electron-dense knobs, 40 X 80 nm in size, which protruded from the membrane of infected erythrocytes, formed focal junctions between endothelial cells and erythrocytes. These junctions resulted in the entrapment of erythrocytes and caused blockage in the capillary lumen. Immunoperoxidase study revealed that P. falciparum antigens and IgG deposits in the capillary basement membrane. This implies that damage to the cerebral capillary could be related to immune mechanisms.
Improved DOP-PCR (iDOP-PCR): a robust and simple WGA method for efficient amplification of low copy number genomic DNA (2017)

Abstract Whole-genome amplification (WGA) techniques are used for non-specific amplification of low-copy number DNA, and especially for single-cell genome and transcriptome amplification. There are a number of WGA methods that have been developed over the years. One example is degenerate oligonucleotide-primed PCR (DOP-PCR), which is a very simple, fast and inexpensive WGA technique. Although DOP-PCR has been regarded as one of the pioneering methods for WGA, it only provides low genome coverage and a high allele dropout rate when compared to more modern techniques. Here we describe an improved DOP-PCR (iDOP-PCR). We have modified the classic DOP-PCR by using a new thermostable DNA polymerase (SD polymerase) with a strong strand-displacement activity and by adjustments in primers design. We compared iDOP-PCR, classic DOP-PCR and the well-established PicoPlex technique for whole genome amplification of both high- and low-copy number human genomic DNA. The amplified DNA libraries were evaluated by analysis of short tandem repeat genotypes and NGS data. In summary, iDOP-PCR provided a better quality of the amplified DNA libraries compared to the other WGA methods tested, especially when low amounts of genomic DNA were used as an input material.
Comparative effects of captopril and nifedipine on diastolic and systolic cardiac function in elderly hypertensive patients. (1988)

Both nifedipine and captopril are effective in the treatment of systemic hypertension in the elderly, but their effects on cardiac function in this age group have not been evaluated. We studied the effects of acute oral administration of 20 mg nifedipine and 12.5 mg captopril on systolic and diastolic cardiac function, as evaluated by a radionuclide method, in 14 elderly hypertensives, mean age 73.4 +/- 3.9 years. The radionuclide studies were performed 1 h after ingestion of nifedipine and 1.5 h after captopril, on separate days. Nifedipine accelerated the heart rate whereas captopril slowed it. Nifedipine increased the ejection fraction by 2.6 +/- 14.6% but captopril increased it by 13 +/- 15.3%. Nifedipine reduced the left ventricular peak ejection rate by 4.8 +/- 21.7% whereas captopril increased it by 18 +/- 24.3%. Nifedipine increased the peak filling rate by 14.3 +/- 41.6% and captopril increased it by 27.6 +/- 32.6%. Nifedipine reduced the time to peak filling rate by 24.9 +/- 27.0%, but captopril reduced it by 68.8 +/- 59.6%. All these differences were statistically significant. Therefore, captopril improves some diastolic and systolic parameters of cardiac function more than nifedipine does. Other parameters are impaired by nifedipine but improved by captopril.
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification (2012)

Medial vascular calcification (MVC) is common in patients with chronic kidney disease, obesity, and aging. MVC is an actively regulated process that resembles skeletal mineralization, resulting from chondro-osteogenic transformation of vascular smooth muscle cells (VSMCs). Here, we used mineralizing murine VSMCs to study the expression of PHOSPHO1, a phosphatase that participates in the first step of matrix vesicles-mediated initiation of mineralization during endochondral ossification. Wild-type (WT) VSMCs cultured under calcifying conditions exhibited increased Phospho1 gene expression and Phospho1(-/-) VSMCs failed to mineralize in vitro. Using natural PHOSPHO1 substrates, potent and specific inhibitors of PHOSPHO1 were identified via high-throughput screening and mechanistic analysis and two of these inhibitors, designated MLS-0390838 and MLS-0263839, were selected for further analysis. Their effectiveness in preventing VSMC calcification by targeting PHOSPHO1 function was assessed, alone and in combination with a potent tissue-nonspecific alkaline phosphatase (TNAP) inhibitor MLS-0038949. PHOSPHO1 inhibition by MLS-0263839 in mineralizing WT cells (cultured with added inorganic phosphate) reduced calcification in culture to 41.8% ± 2.0% of control. Combined inhibition of PHOSPHO1 by MLS-0263839 and TNAP by MLS-0038949 significantly reduced calcification to 20.9% ± 0.74% of control. Furthermore, the dual inhibition strategy affected the expression of several mineralization-related enzymes while increasing expression of the smooth muscle cell marker Acta2. We conclude that PHOSPHO1 plays a critical role in VSMC mineralization and that "phosphatase inhibition" may be a useful therapeutic strategy to reduce MVC.
Pit nucleation in the presence of three-dimensional islands during heteroepitaxial growth (2004)

We present a model in which pit nucleation in thin films is considered to arise from a near-equilibrium nucleation process. In this model the adatom concentration plays a central role in controlling the morphological development of the surface. Although pits relieve elastic energy more efficiently than islands, pit nucleation can be prevented by a high adatom concentration. Three-dimensional islands act as adatom sinks and the lower adatom density in their vicinity promotes pit nucleation. Thermodynamic considerations predict several different growth regimes in which pits may nucleate at different stages of growth depending on the growth conditions and materials system. However, direct comparisons to experimental observations require that kinetics be taken into account as well. The model predicts a wide range of possible morphologies: planar films, islands alone, islands nucleation followed by pit nucleation, and pits alone. The model shows good agreement with experimental observations in III-V systems given the uncertainties in quantifying experimental parameters such as the surface energy.
Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling (2021)

GPR15 is a G protein-coupled receptor (GPCR) proposed to play a role in mucosal immunity that also serves as a major entry cofactor for HIV-2 and simian immunodeficiency virus (SIV). To discover novel endogenous GPR15 ligands, we screened a hemofiltrate (HF)-derived peptide library for inhibitors of GPR15-mediated SIV infection. Our approach identified a C-terminal fragment of cystatin C (CysC95-146) that specifically inhibits GPR15-dependent HIV-1, HIV-2, and SIV infection. In contrast, GPR15L, the chemokine ligand of GPR15, failed to inhibit virus infection. We found that cystatin C fragments preventing GPR15-mediated viral entry do not interfere with GPR15L signaling and are generated by proteases activated at sites of inflammation. The antiretroviral activity of CysC95-146 was confirmed in primary CD4<sup>+</sup> T cells and is conserved in simian hosts of SIV infection. Thus, we identified a potent endogenous inhibitor of GPR15-mediated HIV and SIV infection that does not interfere with the physiological function of this GPCR.
Preliminary evaluation of a robotic measurement system for the assessment of wrist joint spasticity (2020)

Spasticity is a serious problem that affects a large percentage of patients affected by neurological disorders including stroke, multiple sclerosis, cerebral palsy, traumatic injury. Unfortunately, no reliable assessment method of spasticity is currently available. This is a critical missing tool for a rational, assessment-based approach to rehabilitation of patients with neurological impairment. In this paper we propose a robot-based assessment method, focused on the wrist joint, that could be readily integrated with robot treatment protocols. The method consists of the delivery of small and quick rotational disturbances to one of the Degrees of Freedom (DoF) of the wrist (Flexion/Extension DoF). With the aim of validating its consistency and reliability, the method was preliminary tested on a population of healthy subjects, providing a promising initial operational basis.
Patient-specific three-dimensional aortic arch modeling for automatic measurements: clinical validation in aortic coarctation (2020)

The automatically derived aortic arch model, starting from three-dimensional MR images, could be a support to take the measurements in CoA patients and to quickly provide a patient-specific model of aortic arch anomalies.
Hybrid mode coupling of dielectric resonators to microstrip lines (2002)

Coupling between hybrid modes in dielectric resonators and microstrip lines is analyzed. This coupling is due to both magnetic and electric fields. These two kinds of coupling can be treated separately. Two degenerate hybrid modes with the same resonant frequency are excited by magnetic coupling and electric coupling, respectively. Computed data show dependence of the external Q on the distance between the resonator and the line. Experimental measurements are compared with the computed data showing very good agreement.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Interaction-Based Schematics for Representing Mechanical Systems (1992)

Abstract An interaction-based schematic is an abstract graphical representation of the functional interactions within a device expressed in an unambiguous manner that does not require the observer to interpret a detailed picture or textual description of the device. Interaction-based schematics are expected to be of significant value in the development of automated tools for the design, testing, or repair of mechanical and electromechanical devices. They can simplify the process of entering and manipulating behavioral models of an existing or planned device. In this paper we describe the interaction-based schematic representation and provide examples of it in use. We compare it to existing representations. We also discuss why there is a need for such a representation and describe how it may be used.
23.83% efficient mono‐PERC incorporating advanced hydrogenation (2020)

Abstract LONGi Solar Energy Technology Co. Ltd. has achieved 23.83% for a commercial p‐type Cz PERC cell. From a batch of over 40 000 cells, the average line efficiency achieved was 22.5%. R&amp;D studies investigating hydrogenation and degradation show the importance of hydrogenation processes for efficiency improvements and controlling the hydrogen to prevent light‐induced degradation. Such degradation is shown to appear very differently under different illumination and temperature conditions. This degradation impacts V OC , I SC , and especially fill factor. Current injection and thermal anneal can be used to recover the degradation, but the recovery may not be stable. Reducing the hydrogen content within the cell is shown to minimise degradation without sacrificing performance, provided that enough hydrogen is retained to passivate boron‐oxygen defects.
Heat Transfer Measurements during DC Casting of Aluminium. Part II: Results and Verification for Extrusion Ingots (2013)

This chapter contains sections titled: Introduction Experimental Procedure Conclusions
The mechanism of microbial denitrification (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe mechanism of microbial denitrificationE. Weeg-Aerssens, J. M. Tiedje, and B. A. AverillCite this: J. Am. Chem. Soc. 1987, 109, 23, 7214–7215Publication Date (Print):November 1, 1987Publication History Published online1 May 2002Published inissue 1 November 1987https://pubs.acs.org/doi/10.1021/ja00257a065https://doi.org/10.1021/ja00257a065research-articleACS PublicationsRequest reuse permissionsArticle Views228Altmetric-Citations24LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
3-Phenylpropanoic Acid Improves the Affinity of <i>Ruminococcus albus</i> for Cellulose in Continuous Culture (1990)

A continuous-culture device, adapted for use with solid substrates, was used to evaluate the effects of 3-phenylpropanoic acid (PPA) upon the ability of the South African strain Ruminococcus albus Ce63 to ferment cellulose. Steady states of fermentation were established with a dilution rate of 0.17 h, and the extent and volumetric rates of cellulose fermentation were determined over four consecutive days. When the growth medium contained no additions (control), 25 muM phenylacetate alone, 25 muM PPA alone, or 25 muM each of phenylacetate and PPA, the extent of cellulose hydrolysis was determined to be 41.1, 35.7, 90.2, and 86.9%, respectively, and the volumetric rate of cellulose hydrolysis was 103.0, 97.9, 215.5, and 230.4 mg liter h, respectively. To evaluate the effect of PPA availability on affinity for cellulose, the values for dilution rate and extent of cellulose hydrolysis were used in combination with values for maximum specific growth rate determined from previous studies of growth rates and kinetics of cellulose hydrolysis. The findings support the contention that PPA maintains a competitive advantage for R. albus when grown in a dynamic, fiber-rich environment.
Influenza D Virus: Serological Evidence in the Italian Population from 2005 to 2017 (2019)

Influenza D virus is a novel influenza virus, which was first isolated from an ailing swine in 2011 and later detected in cattle, suggesting that these animals may be a primary natural reservoir. To date, few studies have been performed on human samples and there is no conclusive evidence on the ability of the virus to infect humans. The aim of this serological study was to assess the prevalence of antibodies against influenza D virus in human serum samples collected in Italy from 2005 to 2017. Serum samples were analysed by haemagglutination inhibition and virus neutralization assays. The results showed that the prevalence of antibodies against the virus increased in the human population in Italy from 2005 to 2017, with a trend characterized by a sharp increase in some years, followed by a decline in subsequent years. The virus showed the ability to infect and elicit an immune response in humans. However, prevalence peaks in humans appear to follow epidemics in animals and not to persist in the human population.
Optimal Guaranteed Cost Control of Uncertain Linear System (1992)

This paper extends the Riccati equation approach to quadratic stabilizability of an uncertain system. The main result gives a guaranteed cost control which is in a sense optimal with respect to a quadratic cost index.
Vision Transformer for Classification of Breast Ultrasound Images (2021)

Medical ultrasound (US) imaging has become a prominent modality for breast cancer imaging due to its ease-of-use, low-cost and safety. In the past decade, convolutional neural networks (CNNs) have emerged as the method of choice in vision applications and have shown excellent potential in automatic classification of US images. Despite their success, their restricted local receptive field limits their ability to learn global context information. Recently, Vision Transformer (ViT) designs that are based on self-attention between image patches have shown great potential to be an alternative to CNNs. In this study, for the first time, we utilize ViT to classify breast US images using different augmentation strategies. The results are provided as classification accuracy and Area Under the Curve (AUC) metrics, and the performance is compared with the state-of-the-art CNNs. The results indicate that the ViT models have comparable efficiency with or even better than the CNNs in classification of US breast images.
Correlating clinical manifestations with factor levels in rare bleeding disorders: a report from Southern India (2012)

Data on the clinical manifestations of patients with clotting factor defects other than Haemophilia A, B and von Willebrand disease are limited because of their rarity. Due to their autosomal recessive nature of inheritance, these diseases are more common in areas where there is higher prevalence of consanguinity. There is no previous large series reported from southern India where consanguinity is common. Our aim was to analyze clinical manifestations of patients with rare bleeding disorders and correlate their bleeding symptoms with corresponding factor level. Data were collected in a standardized format from our centre over three decades on 281 patients who were diagnosed with rare bleeding disorders (fibrinogen, prothrombin, factor V (FV), FVII, FX, FXI, FXIII and combined FV or FVIII deficiency). Patients with liver dysfunction or those on medications which can affect factor level were excluded. All patients with <50% factor levels were included in this analysis. Patients were analysed for their salient clinical manifestations and it was correlated with their factor levels. The data shows that FXIII deficiency is the commonest and FXI deficiency is the rarest in Southern India. There was no significant difference in bleeding symptoms among those who were < or >1% factor coagulant activities among all disorders, except for few symptoms in FVII and FX deficiency. An international collaborative study is essential to find out the best way of classifying severity in patients with rare bleeding disorders.
Hemoglobin Encapsulated Poly(Ethylene Glycol) Surface Conjugated Vesicles Attenuate Vasoactivity of Cell-Free Hemoglobin (2012)

Vesicles containing Hb can be used as a new therapeutic agent in transfusion medicine to treat anemia and revert hypoperfusion.
Criteria for Ultralyophobic Surfaces (2004)

Very rough surfaces can suspend small liquid drops and produce very large contact angles. This behavior often is referred to as ultralyophobicity or super repellency. It is proposed that two criteria must be met to invoke ultralyophobicity: a contact line density criterion and asperity height criterion. The proposed criteria were tested using experimental data available in the literature and were found to correctly predict suspension of small water drops on model rough surfaces with a wide variety of asperity shapes, sizes, and spacing.