gebhart/patrepeval huggingface dataset:
<sup>63</sup>Ni and <sup>57</sup>Co Uptake and Selectivity of Tin Antimonates of Different Structure (2003)

Tin antimonates of different structure were studied for their uptake of cobalt and nickel in the decontamination of floor drain water and neutral bond water simulates. Selectivity was observed to vary with the structures and degree of crystallinity of the tin antimonates (pyrochlore, rutile, and mixed metal oxides). High selectivity for cobalt of exchangers with pyrochlore structure is attributed to ion exchange of cobalt inside the tunnel structure; nickel uptake evidently took place mostly at the outer surfaces of the materials. Electrostatic forces governed the ion exchange of rutile tin antimonates owing to their particle hydrate structure. With some limitation, the prediction of nickel uptake on tin antimonates from the more abundant cobalt uptake data is considered possible.
[Mono-radiculopathy multiplex--multiple infarction of the cauda equina caused by intravascular lymphomatosis]. (1991)

A 55-year-old man had felt numbness of the bilateral peroneal sides of legs for 6 months. Then hepatosplenomegaly, anemia, body weight loss and fever developed, and a diagnosis of malignant histiocytosis (MH) was made by revealing the presence of innumerable atypical histiocytes with hemophagocytosis in the bone marrow. Soon later, sensory disturbance of bilateral peroneal sides of legs (right side dominant) developed and aggravated with painful dysesthesia and weakness of the legs for the last 2 weeks before death. Electrophysiologically, sensory conduction velocity of the sural nerve was normal and somatosensory evoked potentials from tibial nerve were normal before P15 but were not evoked at all after the lumbar potential, suggesting lumbosacral radiculopathy. Autopsy showed multifocal ischemic lesions and secondary degeneration of the lumbosacral nerve roots associated with necrosis and fibrosis of the radicular vessels and intravascular infiltration of atypical mononuclear cells which were positive for B cell markers. The neurological manifestations and the distribution of ischemic lesions, which were similar to those of vasculopathic mononeuropathy multiplex, would deserve the name of "monoradiculopathy multiplex".
Living Radical Polymerization: Use of an Excess of Nitroxide as a Rate Moderator (2001)

The kinetics of the living radical polymerization of n-butyl acrylate (BuA) in the presence of an excess of N-tert-butyl-N-(1-diethylphosphono-2,2-dimethylpropyl)-N-oxyl (DEPN) as a rate moderator has been studied in the temperature range 115−125 °C. The equilibrium rate constant K = kd/kc between dormant and active chains was determined experimentally from the slope of ln([BuA]0/[BuA]) vs time. It obeys the following Arrhenius relation: K = 4.93 × 105 exp(−119.3 kJ mol-1/RT), i.e., K = 1.09 × 10-10 mol L-1 at 125 °C. Some straightforward analytical kinetic equations that only depend on the excess of DEPN as the experimental parameter were established. These equations were successfully applied to simulate the DEPN-mediated polymerization of n-butyl acrylate initiated by either a styryl-DEPN alkoxyamine or an AIBN/DEPN bicomponent system. Last, the slow degradation of DEPN was considered in order to account for the upward deviation of the kinetics when a great excess of DEPN was used.
<i>CADM2</i> is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice (2022)

ABSTRACT Impulsivity is a multidimensional heritable phenotype that broadly refers to the tendency to act prematurely and is associated with multiple forms of psychopathology, including substance use disorders. We performed genome-wide association studies ( GWAS ) of eight impulsive personality traits from the Barratt Impulsiveness Scale and the short UPPS-P Impulsive Personality Scale (N=123,509-133,517 23andMe research participants of European ancestry), and a measure of Drug Experimentation (N=130,684). Because these GWAS implicated the gene CADM2 , we next performed single-SNP phenome-wide studies ( PheWAS ) of several of the implicated variants in CADM2 in a multi-ancestral 23andMe cohort (N=3,229,317, European; N=579,623, Latin American; N=199,663, African American). Finally, we produced Cadm2 mutant mice and used them to perform a Mouse-PheWAS (“MouseWAS”) by testing them with a battery of relevant behavioral tasks. In humans, impulsive personality traits showed modest chip-heritability (∼6-11%), and moderate genetic correlations ( r g =.20-.50) with other personality traits, and various psychiatric and medical traits. We identified significant associations proximal to genes such as TCF4 and PTPRF , and also identified nominal associations proximal to DRD2 and CRHR1 . PheWAS for CADM2 variants identified associations with 378 traits in European participants, and 47 traits in Latin American participants, replicating associations with risky behaviors, cognition and BMI, and revealing novel associations including allergies, anxiety, irritable bowel syndrome, and migraine. Our MouseWAS recapitulated some of the associations found in humans, including impulsivity, cognition, and BMI. Our results further delineate the role of CADM2 in impulsivity and numerous other psychiatric and somatic traits across ancestries and species.
Postvaccination Symptoms After a Third Dose of mRNA SARS-CoV-2 Vaccination in Patients With Inflammatory Bowel Disease: Results From CORALE-IBD (2022)

The frequency and severity of symptoms after a third mRNA vaccine dose are generally similar or milder than after a second dose for most organ systems.
ChemInform Abstract: THE STRUCTURES AND CONFORMATIONS OF THE MIXED ETHYLENEDIAMINE 1,3‐PROPANE‐DIAMINE COMPLEXES (CR(EN)2(TN))BR3.H2O AND (CR(EN)(TN)2)I3.H2O (1978)

Abstract H 2 O and [Cr(en)(tn)2]I3 ‐ H 2 O. ‐ Beide Titelverbindungen kristallisieren mit Z=8 in der Raumgruppe Pbca.
Retinopatía Diabética y otros hallazgos oftalmológicos en pacientes diabéticos, asistidos por las Fundaciones Cristo Vive y Vida Plena, Bolivia (2013)

espanolObjetivos: este estudio tiene por finalidad presentar los hallazgos oftalmologicos encontrados en pacientes diabeticos controlados por la Fundacion Cristo Vive Bolivia, en la localidad de Bella Vista, provincia Quillacollo de la ciudad de Cochabamba, Bolivia en febrero del 2013. Metodos: Se realiza un estudio descriptivo de corte transversal. Se incluyeron en el estudio 28 pacientes con una media de edad de 57 anos (intervalo entre 36 y 73 anos) en quienes se estudio la presencia de RD mediante Biomicroscopia y examen de fondo de ojo con dilatacion. Ademas se realizo agudeza visual y la busqueda de otras alteraciones oftalmologicas. Resultados: la alteracion oftalmologica encontrada con mayor frecuencia fue la Hipermetropia sin relacion conocida con la Diabetes Mellitus (DM). Del total de pacientes, en el 29% se encontro RD en alguna de sus presentaciones. En cuanto a los pacientes con RD, el 62,5% presento RD no Proliferativa, el 25% ceguera por RD y 12,5% RD proliferativa. Para determinar la relacion entre el tiempo de DM y la RD se agruparon a los pacientes en intervalos de 10 anos, donde encontramos que el 62,5% de los pacientes con afeccion de la retina se concentraron en el intervalo de 11 a 20 anos de diagnostico de DM al momento de la evaluacion oftalmologica. Ninguno de los pacientes con RD alcanzo los niveles de HbA1 esperados, e incluso la mitad de ellos aumentaron sus valores con relacion a un control previo. Conclusiones: el control glicemico y el tiempo de evolucion de la DM repercuten directamente en la progresion de la RD. EnglishObjectives: This study aims to present the ocular findings found in diabetic patients controlled by Fundacion Cristo Vive Bolivia, in the town of Bella Vista, Quillacollo province of Cochabamba, Bolivia in February 2013. Methods: We performed a cross-sectional descriptive study. Were included in the study 28 patients with a mean age of 57 years (range 36 to 73 years) in whom we studied the presence of RD by biomicroscopy and fundus examination with dilation. We also carried out visual acuity and other ophthalmologic search. Results: Ophthalmologic most frequently encountered Hyperopia was no known association with diabetes mellitus (DM). Of all patients, in 29% RD was found in one of their presentations. As for RD patients, 62.5% had no proliferative DR, 25% of blindness and 12.5% RD proliferative DR. To determine the relationship between the time of DM and DR patients were grouped in 10-year intervals, we find that 62.5% of patients with disease of the retina is concentrated in the range of 11-20 years diagnosis of DM at the time of ophthalmologic evaluation. None of the patients with RD reached HbA1c levels expected, and even half of them increased their values in relation to a prior. Conclusions: glycemic control and duration of DM directly affect the progression of DR.
Nuclear cloning, embryonic stem cells, and gene transfer (2001)

An emerging consensus is that somatic cell nuclear transfer (SCNT) for the purpose of creating a child (also called “reproductive cloning”) is not acceptable for both moral and scientific reasons. In contrast, SCNT with the goal of generating an embryonic stem (ES) cell line (so-called “therapeutic cloning”) remains a controversial issue. Although therapeutic cloning holds the promise of yielding new ways of treating a number of degenerative diseases, it is not acceptable to many because the derivation of an ES cell line from the cloned embryo (an essential step in this process) necessarily involves the loss of an embryo and hence the destruction of potential human life.
Supplementary Figure S3 from The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints (2023)

&lt;p&gt;Supplementary Figure S3. Characterization of immune infiltration in MSS CRC outlier.&lt;/p&gt;
Abstract B30: Inhibition of eIF4E/MNK axis by novel MNKDAs reduces breast cancer tumor growth, migration, invasion and metastasis (2017)

Abstract Triple-negative breast cancer (TNBC) represents a molecularly heterogeneous subgrouping of high-risk breast tumors characterized by aggressive behavior, poor prognosis and lack of targeted therapeutic options. The translation initiation factor eIF4E, an oncogene essential for cap-dependent translation of specific mRNAs critical for cell division, cell survival, angiogenesis, and metastasis is commonly overexpressed in primary breast cancers including TNBC. eIF4E therapeutic targeting is considered novel and significant because tumor cells specifically overexpress eIF4E and develop an oncogene addiction to eIF4E, rendering the cells vulnerable to eIF4E inhibition, whereas normal cells are relatively insensitive. Phosphorylation of eIF4E at serine-209 is critical for the oncogenic activity of eIF4E, and it has been suggested that chemical compounds that prevent the phosphorylation of eIF4E could act as effective anticancer drugs. Herein, we report that a novel inhibitor of peIF4E function (Novel Retinamides, NRs), safely and potently suppresses breast tumor formation. Administration of novel retinamides (mnk degrading agents: MNKDAs) blocked the growth of primary breast tumors in MDA-MB-231 xenograft model, TNBC patient derived xenografts (PDX), and reduced the development of lung metastases in an invasive model. Mechanistically, NRs resulted in the degradation of MNKs (MNK1 and MNK2), a key kinase chiefly responsible for phosphorylating and activating eIF4E. This in turn hampered peIF4E involved translation initiation and activation of genes associated with cell proliferation and survival. Furthermore, MNK degradation by NRs also suppressed epithelial-to-mesenchymal transition, a process crucial for metastasis as evident by increased expression of E-cadherin and reduced expression of N-cadherin, fibronectin and vimentin; snail, slug, twist, fibronectin, claudin, lamin, TCF/ZEB-1, beta catenin, MMPs and vimentin. Taken together, the preclinical evidence of tumor regression and metastasis in TNBC models suggest that NRs offers considerable promise as new therapeutic candidate to target TNBC and metastatic breast cancer. Citation Format: Senthilmurugan Ramalingam, Lalji Gediya, Vidya Ramamurthy, Yong Choi, Rena Lapidus, Njar Vincent. Inhibition of eIF4E/MNK axis by novel MNKDAs reduces breast cancer tumor growth, migration, invasion and metastasis. [abstract]. In: Proceedings of the AACR Precision Medicine Series: Targeting the Vulnerabilities of Cancer; May 16-19, 2016; Miami, FL. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(1_Suppl):Abstract nr B30.
Adjacency Labeling Schemes and Induced-Universal Graphs (2015)

We describe a way of assigning labels to the vertices of any undirected graph on up to n vertices, each composed of n/2+O(1) bits, such that given the labels of two vertices, and no other information regarding the graph, it is possible to decide whether or not the vertices are adjacent in the graph. This is optimal, up to an additive constant, and constitutes the first improvement in almost 50 years of an n/2+O(log n) bound of Moon. As a consequence, we obtain an induced-universal graph for n-vertex graphs containing only O(2n/2) vertices, which is optimal up to a multiplicative constant, solving an open problem of Vizing from 1968. We obtain similar tight results for directed graphs, tournaments and bipartite graphs.
Electron Emission from Indium Tin Oxide/Silicon Monoxide/Gold Structure (2005)

A field-emission cathode based upon the increase in the number of allowed conductive energy states in the silicon monoxide (SiO) forbidden gap as well as the increase in the number of interfacial states by indium tin oxide (ITO) ion diffusion into the SiO layer and silicon ion diffusion into the ITO layer while deposition is verified experimentally for the first time. This relatively low-cost electron emitter consists of an ITO layer sputtered on Pyrex glass, followed by an E-beam-evaporated silicon monoxide layer. The emitting layer is gold, deposited on the top of the silicon monoxide. Using ITO as a ground plate, instead of other previously published materials, a significant electron emission enhancement occurred.
A Bayesian Approach to Invariant Deep Neural Networks (2021)

We propose a novel Bayesian neural network architecture that can learn invariances from data alone by inferring a posterior distribution over different weight-sharing schemes. We show that our model outperforms other non-invariant architectures, when trained on datasets that contain specific invariances. The same holds true when no data augmentation is performed.
When is the best time to post on social media? Analysis of 100+ million posts suggests there is no single answer. (2015)

Nemanja Spasojevic, Adithya Rao, Zhisheng Li, and Prantik Bhattacharyya share findings from their large-scale analysis of user behaviour on social networks. Every network has a unique audience with unique reaction patterns, and as such, each network has a “snowflake”-like schedule for ideal response and engagement. City-based or network-based schedules may be better than posting at random times, but these rigid schedules do not account for the unique composition of a specific user’s audience, and therefore are not as effective as personalized schedules.
Quantitative analysis and orientation of Langmuir-Blodgett films by photoacoustic Fourier transform infrared spectroscopy (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTQuantitative analysis and orientation of Langmuir-Blodgett films by photoacoustic Fourier transform infrared spectroscopyE. G. Chatzi, M. W. Urban, H. Ishida, Jack L. Koenig, A. Laschewski, and H. RingsdorfCite this: Langmuir 1988, 4, 4, 846–855Publication Date (Print):July 1, 1988Publication History Published online1 May 2002Published inissue 1 July 1988https://pubs.acs.org/doi/10.1021/la00082a012https://doi.org/10.1021/la00082a012research-articleACS PublicationsRequest reuse permissionsArticle Views72Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
FASTING-MIMICKING DIET REDUCES RISK FACTORS FOR AGING-RELATED DISEASES IN PRECLINICAL AND CLINICAL STUDIES (2019)

Abstract Prolonged fasting promotes stress resistance, but its effects on longevity are poorly understood. Calorie restriction or major dietary composition changes can have profound effects on healthy aging but the inability of many subjects to adhere to chronic and extreme diets together with the potential of adverse effects limit their application. Fasting-mimicking diets (FMDs) are effective in increasing health and lifespan, possibly by inducing stem cell-based regeneration, or as therapies in mouse models of a variety of diseases. FMDs reduce cancer incidence/progression, modulate the immune response, reduce immuno-senescence, ameliorate or reverse disease progression of multiple sclerosis, Type I and Type II diabetes, and reverse inflammatory bowel disease pathology. In a randomized clinical trial, markers/risk factors for metabolic syndrome and other age-related diseases were favorably impacted after completion of 3 FMD cycles. These effects were larger in participants at risk for age-related diseases. Conclusions: We conclude that the FMD was safe and feasible in rodent and human studies. Larger studies on patients with diagnosed diseases are necessary to determine its impact on diabetes and cardiovascular disease treatment.
INVESTIGATION OF THE HYDROGEN STORAGE CAPACITY OF HYDRATES WITH MONTE CARLO SIMULATIONS (2016)

In the present work Grand Canonical Monte Carlo simulations are implemented in order to evaluate the hydrogen storage capacity of hydrates under a wide range of conditions. Hydrates of sII and sH type with or without promoter have been examined. Concerning hydrates of pure H2, our results show that sII hydrates can store up to 3.3 wt. % H2 and sH up to 3.6 wt. % in the pressure range examined (up to 500 MPa). The small cavities of the sII hydrate as well as the small and medium cavities of the sH hydrate are occupied by one H2 molecule at most. The occupancy of the large cavities of both types of hydrates highly depends on pressure. At 400 MPa, the average occupancy of the large cavity of the sII hydrate is 2.8 while the respective value for the sH hydrate is 5.5. Binary hydrates of H2 and promoter present a reduced H2 uptake (less than 1.1 wt. % for sII and less than 1.4 wt. % for sH hydrates). There rather limited values are attributed to the single occupancy of the cavities that are not occupied by the promoter molecules. Furthermore, the results of our simulations do not support the suggestion that the H2 uptake of the binary (sII) H2-THF hydrate can be “tuned” by adjusting the THF concentration in the equilibrium solution. Finally, binary sH hydrates with the promoter occupying the medium instead of the large cavities could be an alternative approach to increase hydrogen uptake.
Block Copolymer Derived Membranes for Sustained Carbon Dioxide−Methane Separations (2010)

Using a reactive block polymer precursor, membranes with a bicontinuous nanostructure containing a poly((N,N-dimethylamino)ethyl methacrylate) phase within a cross-linked poly(cyclooctene) framework were formed. These membranes were evaluated for their CO2 selectivity over CH4. Low pressure experiments demonstrated that the CO2 and CH4 permeabilities remain the same with pure and mixed gas feeds. This shows that the membranes are able to maintain their selectivity for CO2. This selectivity was only slightly decreased at moderate temperature (35 °C) and higher pressures (up to 40 bar) using a 50/50 CO2/CH4 mixed gas feed. The bicontinuous block polymer membranes resist the plasticization effect by using a cross-linked phase to sustain the properties of the selective block, and not by changing chain mobility through new chemistry. These bicontinuous block polymer membranes may be valuable for CO2 removal from natural gas streams.
Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells (2001)

Hepatic stellate cells (HSC) are the main producers of type I collagen in fibrotic liver, and transforming growth factor-β (TGF-β) plays critical roles in stimulating collagen gene expression in the cells mainly at the level of transcription. We have previously identified an upstream sequence of α2(I) collagen gene (COL1A2) that is essential for its basal and TGF-β-stimulated transcription in skin fibroblasts and HSC. We designated this region the TGF-β-responsive element (TbRE). Recently Smad3, an intracellular mediator of TGF-β signal transduction, has been shown to bind to the TbRE and stimulate COL1A2 transcription when overexpressed in skin fibroblasts. In the present study, we demonstrate increased transcription of COL1A2 and plasminogen activator inhibitor-1 (PAI-1) genes and low response to TGF-β in an activated HSC clone derived from a cirrhotic liver. Western blot analyses indicated constitutive phosphorylation of Smad3 in the cells. Immunofluorescence studies revealed that, in contrast to Smad2 that translocated from the cytoplasm to the nucleus upon TGF-β treatment, Smad3 and Smad4 were present in the nucleus irrespective of ligand stimulation. Increased COL1A2 and PAI-1 gene transcription in the cells was not affected by overexpression of inhibitory Smad7. Altogether, the results correlate abnormality in TGF-β/Smad signaling with pathologically accelerated collagen gene transcription in activated HSC. © 2001 Wiley-Liss, Inc.
Highly Selective and Reversible Optical, Colorimetric, and Electrochemical Detection of Mercury(<scp>II</scp>) by Amphiphilic Ruthenium Complexes Anchored onto Mesoporous Oxide Films (2005)

Abstract The colorimetric, fluorimetric, and electrochemical detection of mercury ions by functionalized ruthenium sensitizers in aqueous and non‐aqueous solutions and on anchored TiO 2 films are investigated. Mercury ions coordinate reversibly to the ruthenium sensitizers, inducing a color change and increasing the phosphorescence intensity significantly. The electrochemical data of the adsorbed sensitizer on TiO 2 films show a reversible couple, owing to the percolation through electronic couplings between –NCS ligands of neighboring molecules; upon exposure to a Hg 2+ ‐containing solution, the electrical signal is appreciably reduced. The detection limit for mercury( II ) ions using UV‐vis spectroscopy in homogeneous aqueous solutions is estimated to be ∼ 20 ppb. The results presented herein have important implications in the development of reversible colorimetric, fluorimetric, and electrochemical on–off sensors based on nanocrystalline semiconductor films for the simple, swift, and selective detection of mercury ions in solution.