gebhart/patrepeval huggingface dataset:
Biofunctional rapid prototyping for tissue‐engineering applications: 3D bioplotting versus 3D printing (2003)

Abstract Two important rapid‐prototyping technologies (3D Printing and 3D Bioplotting) were compared with respect to the computer‐aided design and free‐form fabrication of biodegradable polyurethane scaffolds meeting the demands of tissue‐engineering applications. Aliphatic polyurethanes were based on lysine ethyl ester diisocyanate and isophorone diisocyanate. Layer‐by‐layer construction of the scaffolds was performed by 3D Printing, that is, bonding together starch particles followed by infiltration and partial crosslinking of starch with lysine ethyl ester diisocyanate. Alternatively, the 3D Bioplotting process permitted three‐dimensional dispensing and reactive processing of oligoetherurethanes derived from isophorone diisocyanate, oligoethylene oxide, and glycerol. The scaffolds were characterized with X‐ray microtomography, scanning electron microscopy, and mechanical testing. Osteoblast‐like cells were seeded on such scaffolds to demonstrate their potential in tissue engineering. © 2003 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 624–638, 2004
Atomic Resolution Cs-Corrected HR-S/TEM from 80-300kV (2007)

Extract Extended abstract of a paper presented at Microscopy and Microanalysis 2007 in Ft. Lauderdale, Florida, USA, August 5 – August 9, 2007
A Host Transcriptional Signature for Presymptomatic Detection of Infection in Humans Exposed to Influenza H1N1 or H3N2 (2013)

There is great potential for host-based gene expression analysis to impact the early diagnosis of infectious diseases. In particular, the influenza pandemic of 2009 highlighted the challenges and limitations of traditional pathogen-based testing for suspected upper respiratory viral infection. We inoculated human volunteers with either influenza A (A/Brisbane/59/2007 (H1N1) or A/Wisconsin/67/2005 (H3N2)), and assayed the peripheral blood transcriptome every 8 hours for 7 days. Of 41 inoculated volunteers, 18 (44%) developed symptomatic infection. Using unbiased sparse latent factor regression analysis, we generated a gene signature (or factor) for symptomatic influenza capable of detecting 94% of infected cases. This gene signature is detectable as early as 29 hours post-exposure and achieves maximal accuracy on average 43 hours (p = 0.003, H1N1) and 38 hours (p-value = 0.005, H3N2) before peak clinical symptoms. In order to test the relevance of these findings in naturally acquired disease, a composite influenza A signature built from these challenge studies was applied to Emergency Department patients where it discriminates between swine-origin influenza A/H1N1 (2009) infected and non-infected individuals with 92% accuracy. The host genomic response to Influenza infection is robust and may provide the means for detection before typical clinical symptoms are apparent.
Enhanced Hydrolysis of Lignocellulosic Biomass Assisted by a Combination of Acidic Ionic Liquids and Microwave Heating (2016)

Lignocellulosic biomass was hydrolyzed by combining an acidic ionic liquid, 1-(1-butylsulfonic)-3-methylimidazolium hydrogen sulfate, and microwave heating, resulting in high glucose yields and short reaction times. This new approach achieved 40% glucose yield from bagasse within 12 min at 160°C; whereas, almost no glucose was yielded with a well-known method involving H2SO4 and conventional heating within 30 min at the same temperature. It was confirmed that the reaction temperature significantly affected glucose yield and reaction rate; whereas, the concentration of the acidic ionic liquid only affected the reaction rate. Three kinds of lignocellulosic biomass, including bagasse (herbaceous biomass), eucalyptus (hardwood), and Japanese cedar (softwood), were examined. Glucose yield was in the range of 30–40%, indicating that the present method effectively hydrolyzes various kinds of lignocellulosic biomasses.
alpha-synuclein peptides presented on chimeric MHC class Ib molecules prevent loss of <i>substantia nigra</i> neurons in an animal model for Parkinson’s disease (2022)

Abstract Aim An accumulating body of evidence suggests the involvement of alpha-synuclein (aSyn) specific autoreactive T cells in Parkinson’s disease (PD). Here, we investigate whether novel antigen-specific tolerance-inducing biomolecules, that present peptide antigens on MHC class Ib-related molecules, can inhibit neurodegeneration and prevent PD in vivo. Methods The alpha3 domain of the human MHC class Ib molecule HLA-G inhibits T cells via the human ILT-2 or the murine PIRB receptor. We fused this HLA-G alpha3 domain to MHC class I alpha1-alpha2 antigen presenting domains, antigenic peptides and beta2-microglobulin. These single-chain AutoImmunity Modifying Biologicals (AIM Bios) induce antigen-specific tolerogenic CD8+ Treg cells in human cells in vitro and in mice in vivo. We used this platform to prevent autoimmune disease symptoms in mouse models for autoimmune diseases, including an aSynA53T-AAV driven model for PD. Results Single-chain model AIM Bios with MHC-derived antigen-presenting domains and antigenic peptides polarize cognate CD8+ T cells towards a CD8+ CD122+ IL-10 secreting Treg phenotype. Such antigen-specific Treg can also be induced in mice in vivo. Disease-associated aSyn CD8+ epitopes were identified in aSynA53T-AAV PD mice. Corresponding AIM Bios prevented mobility impairments. Post mortem histopathological assessment confirmed the induction a favorable in-situ immune cell composition and the rescue of substantia nigra neurons. The translational potential of this approach deserves further exploration. Supported by grants from the IZKF Wuerzburg A421 and by Aeterna Zentaris Inc.
Glycemic Control, Renal Progression, and Use of Telemedicine Phone Consultations Among Japanese Patients With Type 2 Diabetes Mellitus During the COVID-19 Pandemic: Retrospective Cohort Study (2023)

The COVID-19 pandemic resulted in reduced attendance of outpatient consultations among patients with type 2 diabetes, and these patients also experienced deterioration in kidney function. Difference in consultation modality (in person or by phone) did not affect glycemic control and renal progression of the patients.
A 67% PAE, 100 W GaN power amplifier with on-chip harmonic tuning circuits for C-band space applications (2011)

This paper describes a high efficiency and high output power GaN power amplifier for C-band space applications. The amplifier uses on-chip harmonic tuned FETs to improve dc-to-rf conversion efficiency. A 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> harmonic input tuning circuit is incorporated into each unit on-chip FET cell and realizes high precise control of 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> harmonic input impedance. In addition, 2 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">nd</sup> and 3 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">rd</sup> harmonic output impedances are optimized with external output matching circuits. A 100 W power amplifier with 4-chips achieves a 67.0% PAE (72.4% drain efficiency) at 3.7 GHz under CW operating conditions. To the best of our knowledge, this is the highest efficiency of C-band power amplifiers ever reported with over 100 W output power.
IL‐21 regulates experimental colitis by modulating the balance between T <sub>reg</sub> and Th17 cells (2007)

Regulatory T (T(reg)) cells play a key role in the maintenance of the immune system homeostasis. T(reg) cells can be generated in the periphery under control of TGF-beta, a cytokine involved in the negative control of the immune system. However, TGF-beta cooperates with IL-6 in the generation of Th17 cells, a novel class of effector cells involved in numerous inflammatory diseases, including colitis. Therefore, TGF-beta emerges as a mediator of both anti-inflammatory and pro-inflammatory processes, depending on the local cytokine milieu. Here we demonstrate that IL-21, a type-1 cytokine produced by T cells and involved in the pathogenesis of immune-mediated diseases, prevents the TGF-beta-dependent expression of FoxP3, the master regulator of T(reg) cell commitment, and the induction of suppressive capacity in naive CD4(+) T cells, while promoting the differentiation of Th17 cells. In vivo, CD4(+) naive T cells activated in the presence of TGF-beta and IL-21 failed to suppress colitis while inducing an inflammatory response characterized by high levels of IL-17 and RORgammat, the transcription factor expressed by Th17 cells. Therefore, IL-21 emerges as a key modulator of TGF-beta signaling, leading to the reciprocal differentiation of T(reg) and Th17 cells.
Nerve fibers in the Tumor Microenvironment are co-localized with Tertiary Lymphoid Structures (2020)

ABSTRACT Background B cells and tertiary lymphoid structures (TLS) are reported to be important in the improvement of survival of cancer patients. These secondary lymphoid organs have been associated with the generation of an anti-tumor response. Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancer types and the stromal architecture shapes the intratumoral heterogeneity. The stroma of PDAC is a complex system in which crosstalk takes place between cancer-associated fibroblasts, immune cells, endothelial cells and the cancer cells. Besides immune cells and fibroblasts, there is some limited data about the influence of nerve fibers on cancer progression. Patients and methods Nerve Fiber Density (NFD) was analysed in our cohort of 188 patients with Pancreatic Ductal Adenocarcinoma who underwent pancreatic surgery. We used immunohistochemistry and multiplex imaging to phenotype the immune cell infiltrate. The cell detection classifier measured distance from immune cell to cancer gland and with a heat map we could count TLS. By using Machine learning we were able to define the spatial distribution and counting Tertiary Lymphoid Structures. Results High NFD is significantly associated with prolonged overall survival (HR 1.676 (95%CI 1.126,2.495) for low vs. high NFD, p-value 0.0109). The immune cells surrounding the nerve fibers were phenotyped in B cells, T cells and dendritic follicular cells, matching a TLS. Here we show that small nerve fibers are located at the TLS in Pancreatic Cancer and a high Nerve Fiber Density combined with more than 5 TLS is associated with a better survival (HR 0.388 (95%CI 0.218, 0.689). Conclusion The co-localization of small nerve fibers with TLS is a new finding which has not been described before. However the precise roles of these TLS and nerve fibers remains unknown. These findings unravel future pathways and has the potential to reach new directions into already existing targeted therapy.
Fast Spatial Sampling with Phase Controlled Resonant Scanner (2021)

Through phase controlling a 2D MEMS scanner, we achieve fast and flexible spatial information sampling for use in LiDAR systems. The scanning pattern is designed for desired operational characteristics, e.g. data collection frame time, actuation amplitude, sampling efficiency and Regions-of-Interest (roi) focus. A hardware prototype with wide-band phase control is also demonstrated. This system facilitates fast LiDAR operation at ~ 100hz frame rate.
Construction, Specification, and Mathematical Description of Aspheric Surfaces (1983)

Rotationally symmetrical aspheric surfaces of spectacle lenses are constructed as either "zonal aspherics" or "continuous aspherics." Zonal aspherics consist of annular zones surrounding a central zone with each zone being nominally spherical with progressively lower surface power the farther the zone is from the surface vertex. Aspheric surfaces are often specified by the radial drop in surface power from the center to the edge of the lens (e.g., Welsh Four-drop), but for assessment purposes the surface shape must be specified more precisely. The formulas for the description of continuous aspherics can be manipulated into different forms. Mathematical descriptions are given or developed which will enable theoretical assessment of the performances of all lenses with rotationally symmetrical aspheric surfaces.
Improvement of long-lasting response and antibody affinity by the complexation of antigen with complement C3b (2002)

Complement protein C3 plays a major role in cell regulation and immune response. This last point is mainly due to C3's capacity to act as a bifunctional link between antigen and immunocompetent cells. In a previous work, we have reported the adjuvant effect produced by linking C3 fragments to antigen. In this paper, we characterize the long-term secondary antibody response induced by C3b-antigen complexes. Mice were immunized using either a protein (hen egg lysozyme) or an ovalbumin-derived peptide as antigen. We compared the secondary response elicited by these antigens covalently linked to C3b or emulsified in complete Freund's adjuvant (CFA). Our results provide evidence that C3b linkage induces better long-term adjuvant effect than CFA, resulting in the production of a higher specific IgG titer with a better affinity.
Novel laser resonator configurations for achieving high power and brightness (2006)

We demonstrated our approach with a multimode Nd:YAG laser in which two interferometric combiners are inserted. The interferometric combiners split the multimode distribution into four equal parts, each of a Gaussian distribution, which are then recombined. We also developed a theoretical model for determining the output modal distribution for different laser configurations in which intra-cavity interferometric combiners are inserted.
Photoconductor-metadevices: an enabling platform for dual-optical/electrical modulation of terahertz waves (2022)

Abstract We report a photoconductor-based terahertz metadevice whose transmission characteristics can be comprehensively controlled by a combination of an optical excitation and electrical bias. A metasurface with interdigitated electrodes is proposed to simultaneously support a terahertz resonance and the photoconductive effect, allowing efficient local and global dual-tuning of the carriers in the semiconductor and thus the terahertz wave, based on the simultaneous external optical and electrical stimuli. Experimental results reveal the opposite tuning trend of optical and electrical excitations, leading to the comprehensive transmission modulation of terahertz wave. Our study demonstrates a proof-of-concept device for sophisticated manipulation of terahertz radiation.
Assessment of Wood Pile Deterioration due to Marine Organisms (2004)

In this paper a description of the major groups of marine organisms causing significant wood pile damage is presented. These organisms are divided into two groups: (1) fungi and (2) marine borers. The basic physical and biological characteristics of these organisms are presented, as well as the type of damage that they cause in marine wood piles. The objective of the study presented in this paper is to characterize deterioration of wood piles due to marine organisms and to assess damage in the wood pile zones of a typical waterfront installation. Marine borer activity in Maine coastal waters is assessed through a survey directed to harbor masters; the results of the survey are correlated with historic data. In order to illustrate the type and extent of wood pile deterioration, two case studies in Maine harbors are presented.
Impact of the interface layer on the cycling behaviour and retention of ferroelectric hafnium oxide (2021)

Abstract Reliability is a central aspect of hafnium oxide-based ferroelectric field effect transistors (FeFETs), which are promising candidates for embedded non-volatile memories. Besides the device performance, understanding the evolution of the ferroelectric behaviour of hafnium oxide over its lifetime in FeFETs is of major importance for further improvements. Here, we present the impact of the interface layer in FeFETs on the cycling behaviour and retention of ferroelectric silicon-doped hafnium oxide. Thicker interfaces are demonstrated to reduce the presence of antiferroelectric-like wake-up effects and to improve endurance. However, they show a strong destabilisation of one polarisation state in terms of retention. In addition, measurements of the Preisach density revealed additional insight in the wake-up effect of these metal-ferroelectric-insulator-semiconductor (MFIS) capacitors. Graphic abstract
RMIX: a multiprotocol RMI framework for Java (2004)

With the increasing adoption of Java for parallel and distributed computing, there is a strong motivation for enhancing the expressive elegance of the RMI paradigm with flexible and adaptable communication substrates. Java RMI is an especially powerful and semantically comprehensive framework for distributed Java applications - but the default Java RMI implementation is bound to a concrete wire protocol, JRMP, that is neither interoperable nor very efficient. To address the first issue, libraries have been proposed that provide RMI semantics over different wire protocols such as SOAP or IIOP, making Java interoperable with Web Services and CORBA. Similarly, alternative high performance RMI implementations have been developed. However, none of these solutions are designed to work cooperatively, and each imposes specific constraints on developers. This paper describes RMIX: an RMI framework that supports a variety of dynamically pluggable wire transports underlying a common and uniform RMI facade. RMIX facilitates dynamic protocol negotiation in loosely coupled parallel and distributed systems, and enables the development and deployment of applications that are multiprotocol by nature. Additionally, RMIX offers some enhancements to RMI semantics that are particularly useful in multiuser environments. We describe the design and preliminary implementation of RMIX, present two prototype protocol providers based on the JRMP and SOAP protocols, and outline a transition path from legacy RMI applications to RMIX.
Searching for solvent cavities via electron photodetachment: The ultrafast charge-transfer-to-solvent dynamics of sodide in a series of ether solvents (2009)

It was recently predicted by simulations and confirmed by neutron diffraction experiments that the structure of liquid tetrahydrofuran (THF) contains cavities. The cavities can be quite large and have a net positive electrostatic potential, so they can serve as pre-existing traps for excess electrons created via photodetachment from various solutes. In this paper, we use electron photodetachment via charge-transfer-to-solvent (CTTS) excitation of sodide (Na(-)) to probe for the presence of pre-existing cavities in a series of ether solvents: THF, diethyl ether, 1,2-dimethoxyethane (DME), and diglyme (DG). We find that electrons photodetached from sodide appear after a time delay with their equilibrium spectrum in all of these solvents, suggesting that the entire series of ethers contains pre-existing solvent cavities. We then use the variation in electron recombination dynamics with CTTS excitation wavelength to probe the nature of the cavities in the different ethers. We find that the cavities that form the deepest electron traps turn on at about the same energy in all four ether solvents investigated, but that the density of cavities is lower in DG and DME than in THF. We also examine the dynamics of the neutral sodium species that remains following CTTS photodetachment of an electron from sodide. We find that the reaction of the initially created gas-phase-like Na atom to form a (Na(+),e(-)) tight-contact pair occurs at essentially the same rate in all four ether solvents, indicating that only local solvent motions and not bulk solvent rearrangements are what is responsible for driving the partial ejection of the remaining Na valence electron.
Functionalized oligosiloxanes: Synthesis and UV curing kinetics (2006)

International audience
Frequency response function measurements of rotational degrees of freedom using a non-contact moment excitation based on nanosecond laser ablation (2019)

Frequency response functions (FRFs) are generally measured by investigating the input–output relationship of a target structure. An input is applied to the target structure and the output is measured. Typical vibration tests measure inputs as excitation forces using load cells or similar devices and outputs as velocities or accelerations using laser Doppler vibrometers or accelerometers. Each input or output has three translational degrees of freedom (DOF). Consequently, experimental models established based on such tests have three translational DOF. However, numerical models using finite element analysis (FEA) for existing structures have six DOF at each node (three translational and three rotational DOF). Therefore, numerical models using FEA and experimental models have gaps in their DOF, leading to diverse problems. This study realizes a non-contact measurement method for rotational DOF FRFs using an impulse excitation force generated by laser ablation (LA) where the input is a moment and the output is the velocity. A laser beam radiated from an Nd:YAG pulse laser emitter is divided using a half mirror, halving the laser pulse energy. Then, these laser beams are radiated on two points near a target structure's excitation point. The simultaneous occurrence of LA at these two points realizes a moment that acts on the target structure in a non-contact manner. This experiment uses a 5052 aluminum alloy plate where one end is fixed as a test piece. Both the auto FRFs and cross FRFs for the rotational DOF between two arbitrary points on the test piece are measured. The FRFs obtained by our method agree well with those obtained by FEA, demonstrating its efficacy.
Device Design and Optimization Methodology for Leakage and Variability Reduction in Sub-45-nm FD/SOI SRAM (2008)

Ultrathin-body fully depleted silicon-on-insulator (UTB FD/SOI) devices have emerged as a possible candidate in sub-45-nm technologies and beyond. This paper analyzes leakage and stability of FD/SOI 6T SRAM cell and presents a device design and optimization strategy for low-power and stable SRAM applications. We show that large variability and asymmetry in threshold-voltage distribution due to random dopant fluctuation (RDF) significantly increase leakage spread and degrade stability of FD/SOI SRAM cell. We propose to optimize FD devices using thinner buried oxide (BOX) structure and lower body doping combined with negative back-bias or workfunction engineering in reducing the RDF effect. Our analysis shows that thinner BOX and cooptimization of body doping and back biasing are efficient in designing low-power and stable FD/SOI SRAM cell in sub-45-nm nodes.
IKEA : en vinnande marknadsstrategi (2002)

I uppsatsen har vi tagit upp sambandet mellan IKEAs framgang och dess marknadsstrategier. For att forsta deras marknadstrategi satte vi och in i deras koncept som i sjalva verket har format foretag ...
AMINOACIDES, PEPTIDES ET CHIMIE HETEROCYCLIQUE (1994)

Abstract In this report the importance of heterocycles in amino acid and peptide chemistry is pointed out. Neuroexcitatory amino acids, kainic acid, quisqualic acid, of which new syntheses are given, are representative examples of the role of the heterocycle in the recognition of receptor sites. It is also shown that a heterocyclic structure can replace advantageously a peptide turn. The synthesis of a functionnalized diazepinone, a γ‐turn mimetic, is described