gebhart/patrepeval huggingface dataset:
Post Operative Pain after Cholecystectomy: Conventional Laparoscopy Versus Single Incision Laparoscopic Surgery (SILS) (2010)

This study was done to compare postoperative pain after cholecystectomy done by single incision laparoscopic surgery (SILS) versus conventional four port laparoscopy. 100 patients undergoing cholecystectomy for symptomatic gall stones who were willing to be part of this comparison were included in the study. Patients were randomized into two groups of 50 each. Only conventional instruments were used in both groups to keep the cost of surgery same. No special ports, roticulating instruments or flexible telescopes were used. Pain score was checked after 6 hours of surgery using a visual analogue score. We observed that there was no statistically significant difference in overall post operative pain. But on further analysis, we found significant difference in post operative pain score in latter half of our series of SILS when compared to conventional laparoscopic cholecystectomy and also the first half of the SILS group. There was also significant difference between operative times in earlier and latter half of SILS. Single incision laparoscopic surgery is a feasible and a promising method for cholecystectomy. It is possible to do this procedure with out using special equipment. Although there was no significant difference in overall postoperative pain, there is a possibility that after the initial learning curve, when the operative time reduces, the postoperative pain may also decrease. More studies are needed.
Experimental validation of protection blinding on DC aircraft electrical power systems with power-dense energy storage (2016)

Power-dense energy storage systems (ESS) are being considered to maintain power quality of DC power distribution systems on future more electric aircraft (MEA). However, during high impedance fault conditions, the behaviour of such sources can dampen the fault response of converter fed primary generation, resulting in protection blinding. This paper reports on the experimental validation of protection blinding on a scaled down, low voltage DC power system testing facility and the impact on the performance of a commercial solid-state power controller. It is shown that the inherent response of a fast acting and power-dense ESS integrated at a downstream location on the network can significantly increase the trip-time of a conventional i2t based generator feeder protection device during such conditions. A more configurable protection device with adaptive settings that enables more consistent protection performance to mitigate the protection blinding effects caused by ESS integration is also proposed and verified experimentally.
A dinuclear rhenium complex, {[(C<sub>18</sub>H<sub>24</sub>N<sub>2</sub>)Re(CO)<sub>3</sub>]<sub>2</sub>(μ-C<sub>12</sub>H<sub>12</sub>N<sub>2</sub>)}(PF<sub>6</sub>)<sub>2</sub>·2CH<sub>2</sub>Cl<sub>2</sub> (2003)

A new ReI complex has been synthesized by reflux methods, viz. μ-ethyl­ene-1,2-di-4-pyridyl-κ2N:N′-bis­[fac-tri­carbonyl(4,4′-tert-butyl-2,2′-bi­pyridine)­rhenium(I)] hexa­fluoro­phos­phate di­chloro­methane disolvate, [Re(μ-C12H12N2)(C18H24N2)2(CO)6](PF6)2·2CH2Cl2. The compound is a centrosymmetric dinuclear complex. The self-assembled structure contains octahedral Re centers, connected by a 1,2-bis(4-pyridyl)­ethyl­ene linking group.
Faculty Opinions recommendation of Protective effect of pristane on experimental autoimmune uveitis. (2011)

This study evaluates the effects of pristane and phytol, two mineral oils with pro-oxidative effects, on the course of experimental autoimmune uveitis. C57BL6 mice were immunized with IRBP1-20 peptide emulsified in CFA and treated five days prior to immunization with phytol or with pristane or with PBS as control. Administration of pristane reduces the incidence and severity of IRBP-induced uveitis as demonstrated by the decrease in vasculitis and inflammatory foci in fundus and by a reduction in histological damages and leukocyte infiltration compared to untreated or phytol-treated mice. The protective effect observed is associated with a decreased activation of peripheral CD4+ and CD8+ T lymphocytes and a decrease in the intensity of the Th1 and Th17 autoimmune response to IRBP in pristane-treated mice compared to control mice, as evidenced by the decreased production of IFNγ and IL17 by IRBP-specific lymphocytes from lymph nodes draining the site of immunization and by the increased production of anti-IRBP IgG1 over IgG2a. In addition, HUVEC and ARPE-19 cells incubated with the sera of mice treated with pristane presented a reduced production of H(2)O(2). The benefit of lowering the systemic oxidative stress by pristane in the course of EAU was confirmed by injecting the antioxidant NAC in IRBP-immunized mice. As pristane, NAC decreased clinical and histological inflammation of the retina and preserved the integrity of the hemato-retinal barrier. Finally, the protective effect of pristane on the development of EAU suggests that some mineral oils may represent a new therapeutic strategy in human uveitis.Copyright © 2011 Elsevier B.V. All rights reserved. PMID: 21896286
3D VSG: Long-term Semantic Scene Change Prediction through 3D Variable Scene Graphs (2023)

Numerous applications require robots to operate in environments shared with other agents, such as humans or other robots. However, such shared scenes are typically subject to different kinds of long-term semantic scene changes. The ability to model and predict such changes is thus crucial for robot autonomy. In this work, we formalize the task of semantic scene variability estimation and identify three main varieties of semantic scene change: changes in the position of an object, its semantic state, or the composition of a scene as a whole. To represent this variability, we propose the Variable Scene Graph (VSG), which augments existing 3D Scene Graph (SG) representations with the variability attribute, representing the likelihood of discrete long-term change events. We present a novel method, DeltaVSG, to estimate the variability of VSGs in a supervised fashion. We evaluate our method on the 3RScan long-term dataset, showing notable improvements in this novel task over existing approaches. Our method DeltaVsgachieves an accuracy of 77.1% and a recall of 72.3%, often mimicking human intuition about how indoor scenes change over time. We further show the utility of VSG prediction in the task of active robotic change detection, speeding up task completion by 66.0% compared to a scene-change-unaware planner. We make our code available as open-source.
Studies on the Synthesis of Landomycin A. Synthesis of the Originally Assigned Structure of the Aglycone, Landomycinone, and Revision of Structure (2004)

The originally proposed structure (2) of landomycinone, the aglycone of landomycin A, has been synthesized and shown to be nonidentical to the naturally derived landomycin A aglycone. The synthesis of 2 features the Dötz benzannulation reaction of chromium carbene 5 and alkyne 6, and the intramolecular Michael-type cyclization reaction of the phenolic naphthoquinone 20. It is proposed that natural landomycinone possesses the alternative structure 3, but attempts to access this structure via the Michael-type cyclization of the isomeric phenolic naphthoquinone 38 have been unsuccessful.
Minimizing Communication in All-Pairs Shortest Paths (2013)

We consider distributed memory algorithms for the all-pairs shortest paths (APSP) problem.Scaling the APSP problem to high concurrencies requires both minimizing inter-processor communication as well as maximizing temporal data locality.The 2.5D APSP algorithm, which is based on the divide-andconquer paradigm, satisfies both of these requirements: it can utilize any extra available memory to perform asymptotically less communication, and it is rich in semiring matrix multiplications, which have high temporal locality.We start by introducing a block-cyclic 2D (minimal memory) APSP algorithm.With a careful choice of block-size, this algorithm achieves known communication lower-bounds for latency and bandwidth.We extend this 2D block-cyclic algorithm to a 2.5D algorithm, which can use c extra copies of data to reduce the bandwidth cost by a factor of c 1/2 , compared to its 2D counterpart.However, the 2.5D algorithm increases the latency cost by c 1/2 .We provide a tighter lower bound on latency, which dictates that the latency overhead is necessary to reduce bandwidth along the critical path of execution.Our implementation achieves impressive performance and scaling to 24,576 cores of a Cray XE6 supercomputer by utilizing well-tuned intra-node kernels within the distributed memory algorithm.
Characterization of autoreactive T cells to the autoantigens hnRNP-A2/RA33 and filaggrin in patients with rheumatoid arthritis and controls (2001)

We discuss the presence of anti-keratin antibodies (AKA) of the IgG class in patients with defined juvenile idiopathic arthritis (JIA). An indirect immunofluorescence test and rat oesophagus substrate was used for the detection and quantification of AKA antibodies in patients sera. Overall 33/60 patients with JIA had sera positive for AKA (55 %, P = 0,0001) ranging from 1:10 to 1:160 dilutions. Following idiopathic arthritis of childhood classification criteria AKA occurred in 2/7 patients with systemic disease (28,6 %), in 13/30 patients with RF negative polyarthritis (43,3 %, P = 0,008) and in 15/18 RF positive polyarthritis (83,3 %, P = 0,000002). AKA were also found in a small cohort of patients with oligoarthritis (1/3) and psoriatic arthritis (2/2). AKA positivity occurred in 3/26 healthy controls at a 1:20 dilution. The presence of AKA was correlated as well as with the severity of the disease. Our study revealed that AKA was present overall in 18/29 patients (62%) with severe JIA and in 12/26 patients (46,2 %) with non-severe disease, however this did not reach statistical significance (P = 0,18). We also observed that AKA remained positive regardless of disease activity. AKA were detectable in 55,6 % patients with active JIA and in 48,6 % patients in the complete or near remission.
Is Ureteroscopy First Line Treatment for Pediatric Stone Disease? (2007)

Improved ureteroscopic access to stones throughout the pediatric urinary tract and stone-free rates that are comparable to the adult population have led to the adoption of ureteroscopy as first line therapy in children at our institution.
An in situ structural study of the thermal decomposition reactions of the ammonium thiomolybdates, (NH4)2Mo2S12·2H2O and (NH4)2Mo3S13·2H2O (2001)

A combined in situ Mo K-edge extended X-ray absorption fine structure (EXAFS) and X-ray powder diffraction study has been carried out to follow the evolution of structure in the thermal decomposition of the ammonium thiomolybdates, (NH4)2Mo3S13·2H2O and (NH4)2Mo2S12·2H2O, under nitrogen. Additional information on the course of the decomposition reactions has been obtained from thermogravimetric and differential thermal analysis, and from IR spectroscopy. Molybdenum–molybdenum bonded triangular units are found to persist in all the amorphous intermediate decomposition products of (NH4)2Mo3S13·2H2O, and are also formed during the decomposition of (NH4)2Mo2S12·2H2O. Structural models for the intermediates are presented. The final decomposition product in both cases is poorly crystalline MoS2.
The design of a computer controlled planar manipulator (2005)

The research presented in this report consists of the complete design, construction, and simulation of a planar manipulator device which was intended to be computer controlled. Designed as a research tool, the Planar Manipulator was instrumented for position, velocity, and torque control at each joint. A modularity feature was also designed into the robot to allow for interchanging any electromechanical components and to enable structural substitutions for investigations into manipulator elasticity and vibrations. The completed robot was run under open loop control and successfully exceeded performance specifications and design criteria. In addition a simulation program based upon a mathematical model of the Planar Manipulator was developed. The model used the voltage into the power amplifiers as the system input and the joint angular position, velocity, and acceleration as the system output. The simulation program reasonably represented the system when compared to experimental results for both a step input function and a sinusoidal input function at each joint.
Frequency of preclinical Alzheimer’s disease in Japanese clinical study settings: a meta-analysis (2022)

Abstract Background Many of earlier studies reporting the frequency of preclinical Alzheimer’s disease (AD) among cognitive normal (CN) individuals have based on the clinical study cohort from Western countries, and it has not been validated whether the frequency of preclinical AD in Asian country cohort may differ from that in Western countries. Methods We conducted meta-analysis of earlier literature and original data of 4 Japanese cohort study (i.e., AMED-Preclinical, Brain/Minds Aging Imaging Study, J-ADNI, and A4 study screening conducted in Japan), among which we incorporated cognitive normal (CDR = 0) clinical study participants who were examined their amyloid status by amyloid-PET or CSF. Results In total, among the reviewed 658 Japanese CN participants from 10 different groups, 103 turned out to be amyloid positive, and the estimated overall frequency of preclinical AD (of any stage) was 17.2% (95% CI: 12.0 – 23.0%) with a high statistical heterogeneity of I 2 = 64%. In meta-regression, being the Japanese cohort was barely significantly associated with the lower frequency of preclinical AD ( p = 0.048 ). Conclusions Our study suggested that currently there is no robust evidence to support the lower frequency of preclinical AD in clinical study settings of Japan than that of Western countries.
Effect of mechanical deformation on structure and function of polymorphonuclear leukocytes (1997)

The present studies were designed to test the hypothesis that mechanical deformation of polymorphonuclear leukocytes (PMN) leads to functional changes that might influence their transit in the pulmonary capillaries. Human leukocytes were passed through 5- or 3-micron-pore polycarbonate filters under controlled conditions. Morphometric analysis showed that the majority of PMN were deformed and that this deformation persisted longer after filtration through 3-micron filters than through 5-micron filters (P < 0.05) but did not result in the cytoskeletal polarization characteristic of migrating cells. Flow cytometric studies of the filtered PMN showed that there was a transient increase in the cytosolic free Ca2+ concentration after both 3- and 5-micron filtration (P < 0.01) with an increase in F-actin content after 3-micron filtration (P < 0.05). Although L-selectin expression on PMN was not changed by either 5- or 3-micron filtration, CD18 and CD11b were increased by 3-micron filtration (P < 0.05). Priming of the PMN with N-formyl-methionyl-leucyl-phenylalanine (0.5 nM) before filtration resulted in an increase of CD11b by both 5 (P < 0.05)- and 3-micron (P < 0.01) filtration. Neither 5- nor 3-micron filtration induced hydrogen peroxide production. We conclude that mechanical deformation of PMN, similar to what occurs in the pulmonary microvessels, induces both structural and functional changes in the cells, which might influence their passage through the pulmonary capillary bed.
Phase IIa safety and efficacy of milciclib, a pan-cyclin dependent kinase inhibitor, in unresectable, sorafenib-refractory or -intolerant hepatocellular carcinoma patients. (2020)

e16711 Background: Current hepatocellular carcinoma (HCC) therapeutics, tyrosine kinase inhibitors (TKI) and checkpoint inhibitors (CI), provide limited improvement in overall survival, suggesting the need to identify drugs with broad-spectrum mechanisms of action, used alone or in combination with a TKI or CI. Milciclib, a pan cyclin dependent kinase inhibitor, exhibited anti-cancer activity in refractory solid malignancy patients. The primary objective of this trial was to evaluate safety and tolerability of milciclib in sorafenib-refractory or intolerant advanced HCC patients. Methods: Single arm and multi-center study in advanced HCC patients was conducted in Italy, Greece and Israel. Milciclib was administered orally for up to 6 cycles. Each cycle consisted of 100mg milciclib daily for 4d on/3d off/week for 4 weeks. Safety assessment was the primary endpoint and secondary endpoints included progression free survival (PFS), time to progression (TTP) and clinical benefit rate (CBR). Results: A total of 31 patients were enrolled and 28 were evaluable for efficacy, of which 14 (50%) completed 6-months of treatment. Milciclib was well-tolerated with manageable toxicities. Eighteen of 31 treated patients had drug-related adverse events (AEs) with most frequent (≥5%) occurrence of drug-related diarrhea, nausea, asthenia, fatigue, retinal hemorrhage, rash and myalgia. No drug-related deaths were recorded. Nine of 14 patients (64%) continued treatment under Compassionate Use after study completion. Seven patients received milciclib until 9, 9, 10, 11, 13, 13 and 16 months. The remaining 2 patients are in the 16 th month of treatment. Clinical response to treatment, assessed by mRECIST (independent radiological review), is shown in the Table. Both median TTP and PFS were 5.9 months. Conclusions: Milciclib, acting via a new mechanism, was safe, well-tolerated and met primary and secondary endpoints with 61% CBR. These promising clinical data warrant further evaluation of milciclib. Clinical trial information: NCT03109886 . [Table: see text]
Fast configuration of MEMS-based storage devices for streaming applications (2009)

An exciting class of storage devices is emerging: the class of Micro-Electro-Mechanical storage Systems (MEMS). Properties of MEMS-based storage devices include high density, small form factor, and low power. The use of this type of devices in mobile infotainment systems, such as video cameras is not at all obvious. We must explore their configuration and assess their benefit with respect to existing devices, such as Flash.
Image magnification using level-set reconstruction (2005)

Image magnification is a common problem in imaging applications, requiring interpolation to "read between the pixels". Although many magnification/interpolation algorithms have been proposed in the literature, all methods must suffer to some degree the effects of imperfect reconstruction: false high-frequency content introduced by the underlying original sampling. Most often, these effects manifest themselves as jagged contours in the image. The paper presents a method for constrained smoothing of such artifacts that attempts to produce smooth reconstructions of the image's level curves while still maintaining image fidelity. This is similar to other iterative reconstruction algorithms and to Bayesian restoration techniques, but instead of assuming a smoothness prior for the underlying intensity function it assumes smoothness of the level curves. Results show that this technique can produce images whose error properties are equivalent to the initial approximation (interpolation) used, while their contour smoothness is both visually and quantitatively improved.
Cranberry constituents affect fructosyltransferase expression in Streptococcus mutans. (2009)

NDM at concentrations between 0.2/mL and 1mg/mL significantly (P<.05) decreased secretion of extracellular FTF, as well as down-regulated ftf expression in a dose-dependent manner. NDM also markedly reduced the luciferase activity under the ftf promoter.
The long-term mortality of spontaneous bacterial peritonitis in cirrhotic patients: A 3-year nationwide cohort study (2015)

Cirrhotic patients with SBP have a 2.5-fold increase of 3-year mortality, compared to those without ascites.
Enhancing Data Integrity and Privacy in the Cloud: An Agenda (2013)

To address users' security concerns, cloud service providers must implement strategies that enhance data integrity and privacy. New data auditing and encryption methods open a path toward these goals.
Fortune Monitor or Fortune Teller: Understanding the Connection between Interaction Patterns and Financial Status (2011)

We have deployed mobile phones to more than 100participants in a community split into two phases. In this paper, we use this unique dataset to study the correlation between users' call and Bluetooth face-to-face interaction patterns, and their financial status. We show that such correlation exists on an individual level. We find that the interaction diversity measure correlates more strongly with individual's financial status compared with other social behavior measures such as the number of contacts and length of interactions, and it is much less sensitive to personality variance. We also discuss in this paper the long-lasting sociological theory that a diverse relationship leads to a more successful financial status. Our evidence tends to support a behavioral and psychological oriented theory opposite to the prevailing arguments: Social diversity exhibited by our participants are influenced by their income as well.
Lateral Extracavitary Approach for Thoracic and Thoracolumbar Spine Trauma: Operative Complications (1998)

Decompression and stabilization of acute thoracolumbar fractures with the LECA in the acute setting is associated with a 55% incidence of morbidity. Whereas some of this morbidity may be attributed to the effects of the injury, there is a certain intrinsic morbidity associated with the LECA. Although this morbidity may compare favorably with that of sequential ventral/dorsal approaches, the biomechanical advantages obtained with a combined ventral and dorsal construct must be balanced against the inherent morbidity of such approaches.
X-Haul Solutions for Different Functional Split Options Using THz and Sub-THz Bands (2022)

In a variety of scenarios, from temporal events to emergencies, mobile cell also known as cell on wheels (COW) or cell on light truck (COLT) is considered as a widespread solution for temporarily increasing the capacity of the cellular networks. Flying cells are small-sized, low-cost, fast deployment options of mobile cells. In the fifth generation (5G) of cellular systems, the functionalities of radio access network (RAN) components i.e., centralized unit (CU), distributed unit (DU), and radio unit (RU) vary in different functional splits and thus have different data rate requirements for the interfaces between the units. The initial target of the paper is to provide a basic overview of different functional splits introduced in 5G, and highlight the throughput requirements of the transport X-Haul links of those functional splits. Moreover, the target is to investigate the option of utilizing terahertz (THz) and sub-THz wireless radio link to meet a high data rate requirement. In this work, we considered two frequency bands i.e., 105 GHz and 220 GHz, and estimated the handling capacity of the X-Haul link for different supporting bandwidths and distances. The X-Haul link capacity requirements also depend upon the air interface configuration, therefore, in this work different bandwidths, the number of antennas, and MIMO layer configurations are considered. The analysis is applicable for the terrestrial as well as for the flying platforms. Interestingly, it is found that with a lower functional split i.e., split 8, the X-Haul data requirement is above 150 Gbps for a simple 5G system with only 100 MHz bandwidth and 32 antennas.