gebhart/patrepeval huggingface dataset:
Wireless Device-to-Device Communications with Distributed Caching (2012)

We introduce a novel wireless device-to-device (D2D) collaboration architecture that exploits distributed storage of popular content to enable frequency reuse. We identify a fundamental conflict between collaboration distance and interference and show how to optimize the transmission power to maximize frequency reuse. Our analysis depends on the user content request statistics which are modeled by a Zipf distribution. Our main result is a closed form expression of the optimal collaboration distance as a function of the content reuse distribution parameters. We show that if the Zipf exponent of the content reuse distribution is greater than 1, it is possible to have a number of D2D interference-free collaboration pairs that scales linearly in the number of nodes. If the Zipf exponent is smaller than 1, we identify the best possible scaling in the number of D2D collaborating links. Surprisingly, a very simple distributed caching policy achieves the optimal scaling behavior and therefore there is no need to centrally coordinate what each node is caching.
Retrospective Computed Tomography Mapping of Intrapleural Air May Demonstrate Optimal Window for Ultrasound Diagnosis of Pneumothorax (2013)

The CT scans demonstrate that intrapleural air most often collects along the mediastinum between ribs 3 and 6 on either side of the chest. Although no USs were performed in this retrospective study, one may infer that a parasternal approach along rib interspaces 3 to 6 is an easy and sensitive window to diagnose pneumothorax with US.
A Current Regulator for Inverter-Based Massively Column-Parallel &lt;inline-formula&gt; &lt;tex-math notation="TeX"&gt;$\Delta \Sigma$&lt;/tex-math&gt;&lt;/inline-formula&gt; ADCs (2014)

The inverter-based switched-capacitor delta-sigma (ΔΣ) analog-to-digital conversion (ADC) has become popular due to its low-voltage low-power capabilities. This brief proposes a new current regulation technique for the inverter-based circuits. The proposed circuit controls both the power supply and the common-mode levels in response to the process-voltage-temperature variations by sensing the current in the replica inverter. The proposed sense and regulation circuit is implemented for the regulation of massively column-parallel ΔΣ ADCs, and the measurement results prove that the performance is well controlled regardless of the variations.
Short-Term Second Language and Music Training Induces Lasting Functional Brain Changes in Early Childhood (2014)

Abstract Immediate and lasting effects of music or second-language training were examined in early childhood using event-related potentials. Event-related potentials were recorded for French vowels and musical notes in a passive oddball paradigm in thirty-six 4- to 6-year-old children who received either French or music training. Following training, both groups showed enhanced late discriminative negativity (LDN) in their trained condition (music group–musical notes; French group–French vowels) and reduced LDN in the untrained condition. These changes reflect improved processing of relevant (trained) sounds, and an increased capacity to suppress irrelevant (untrained) sounds. After 1 year, training-induced brain changes persisted and new hemispheric changes appeared. Such results provide evidence for the lasting benefit of early intervention in young children.
In Vitro Measurement of Protective Mycobacterial Immunity: Antigen-Specific Expansion of T Cells Capable of Inhibiting Intracellular Growth of Bacille Calmette-Guérin (2000)

We investigated the ability of T cells expanded with mycobacterial antigens from healthy purified protein derivative-reactive donors and bacille Calmette-Guérin (BCG)-vaccinated volunteers to inhibit intracellular growth of BCG. Peripheral blood mononuclear cells were incubated for 7 days with mycobacterial whole lysate, live BCG, tetanus toxoid as control antigen, or medium alone. Autologous monocytes were separated by plastic adherence, allowed to mature for 6 days, and infected with BCG before serving as target cells. Expanded effector cells were cocultured with target cells for 72 h. Cocultures were then treated with 0.2% saponin to lyse infected monocytes and release intracellular BCG. Quantities of viable BCG present in these lysates were studied by colony-forming unit counting and radiometric labeling. We reproducibly found that lymphocytes expanded with mycobacterial whole lysate or live BCG significantly inhibited the intracellular growth of BCG, compared with lymphocytes expanded with tetanus toxoid or rested in medium. In addition, BCG vaccination enhanced the ability of T cells to inhibit intracellular mycobacterial growth in 3 of 5 volunteers. This assay may be useful for estimates of protective immunity induced by tuberculosis vaccines in human trials.
Mechanisms of Inappropriate Defibrillator Therapy in a Modern Cohort of Remotely Monitored Patients (2013)

Despite many technological advances, inappropriate ICD shocks still occur but at very low rates and SVT with 1:1 atrioventricular association represents their most common mechanism.
A nanoplasmonic probe for near-field imaging (2011)

We demonstrate a nanoplasmonic probe that incorporates a subwavelength aperture coupled to a fine probing tip. This probe is used in a hybrid near-field scanning optical microscope and atomic force microscope system that can simultaneously map the optical near-field and the topography of nanostructures. By spatially isolating but optically coupling the aperture and the localizing point, we obtained near-field images at a resolution of 45 nm, corresponding to λ/14. This nanoplasmonic probe design overcomes the resolution challenges of conventional apertured near-field optical probes and can provide substantially higher resolution than demonstrated in this work.
Nanostructured Silica Hybrids bearing Cationic Substructures by Liquid Crystal Templating with Anionic Surfactants (2010)

International audience
Development and validation of a sensitive LC‐MS/MS method with electrospray ionization for quantitation of rhein in human plasma: application to a pharmacokinetic study (2008)

A highly sensitive and specific LC-MS/MS method has been developed and validated for the estimation of rhein with 100 microL human plasma using celecoxib as an internal standard (IS). The API-4,000 Q-Trap LC-MS/MS was operated under multiple reaction-monitoring mode using the electrospray ionization technique. The assay procedure involved extraction of rhein and IS from human plasma with acetonitrile, which yielded consistent recoveries of 36.01 and 65.85% for rhein and IS, respectively. The total chromatographic run time was 5.0 min and the elution of rhein and IS occurred at approximately 1.60 and 3.96 min, respectively. The resolution of peaks was achieved with 0.01 m ammonium acetate (pH 6.0):acetonitrile:methanol (30:58:12, v/v) on an Inertsil ODS-3 column. The method was proved to be accurate and precise at a linearity range of 0.005-5.00 microg/mL with a correlation coefficient (r) of >or=0.995. The lower limit of quantitation was 0.005 microg/mL. The intra- and inter-day precision and accuracy values were found to be within the assay variability limits as per the FDA guidelines. Rhein was found to be stable in the battery of stability studies. The application of the assay to pre-clinical pharmacokinetic studies confirmed the utility of the assay to derive pharmacokinetic parameters.
ChemInform Abstract: Structure of the Tetrachlorohydroxotellurate(IV) Anion in KTeCl4(OH). times.0.5 H2O and KTeCl4(OH). (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Image reconstruction for multiphoton fluorescence microscopy (2008)

We present a general image reconstruction methodology for multiphoton fluorescence microscopy. The method is primarily based on Markov random field modeling of the detected image data. Evaluation on two-photon-excitation-(TPE) and two-photon-excited-4PI-microscopy images shows high quality artifact-free reconstruction. Image reconstruction for multiphoton imaging modalities such as TPE and 4PI may find potential application in nano-bioimaging and optical imaging.
Impact of Semiautomated versus Manual Image Segmentation Errors on Myocardial Strain Calculation by Magnetic Resonance Tagging (1994)

Errors in the segmentation of myocardial contours are significantly greater than those of the tags. Strain calculations should be based solely on segmentation of MR tags to avoid significant errors, particularly in radial strain estimates.
Commissioning an in‐room mobile <scp>CT</scp> for adaptive proton therapy with a compact proton system (2018)

Based on this study, we believe the AIRO can be used offline for adaptive proton therapy on a compact double scattering proton therapy system.
Phase I trial of enzalutamide in combination with gemcitabine and nab-paclitaxel for the treatment of advanced pancreatic cancer. (2015)

467 Background: Despite recent advances, patients with metastatic pancreatic cancer have a very poor prognosis with a median survival of less than 1 year. Sex steroid hormones may play an important role in the growth and progression of pancreatic cancer. Anti-androgen drugs have demonstrated to have activity in pre-clinical pancreatic cancer models. In this Phase 1a/Ib trial, we evaluated the safety and tolerability of the combination of enzalutamide, a novel androgen receptor (AR) antagonist with gemcitabine and nab-paclitaxel. Methods: Pts with histologically confirmed metastatic pancreatic adenocarcinoma were included in this trial as a first-line treatment. Standard 3+3 dose escalation design was used to evaluate 2 dose levels of enzalutamide: 80 mg and 160 mg daily. Gemcitabine 1,000 mg/m2 was administered IV on days 1, 8 and 15 of 28-day cycle. The dose of nab-paclitaxel was 125 mg/m2 IV on days 1, 8 and 15. The DLT period was 28-days or until the beginning of the second cycle. Imaging studies were performed every 2 cycles. Results: Eight pts with stage IV pancreatic cancer have been enrolled in this trial, 5 pts at the first dose level and 3 pts at the second dose level. The median age was 64 years (50-80 years). All pts were male with an ECOG performance status of 1. Five pts had liver metastases. One patient was non-evaluable for DLT. No DLTs have been observed. Grade 3 treatment related AEs include febrile neutropenia (n=1), Neutropenia (n=1), ALT elevation (n=1). Grade 2 anemia and thrombocytopenia was seen in one patient. Grade 1 AEs included anemia (n=2), neutropenia (n=4), thrombocytopenia (n=3), diarrhea (n=1), fatigue (n=2), pruritis (n=1), nausea (n=1), hyponatremia (n=1) and AST elevation (n=1). Three pts had restaging studies performed and all had stable disease by RECIST criteria. There were decreases in size of target lesions in all the 3 patients along with a decrease in CA 19-9 levels. Conclusions: Enzalutamide at the dose of 160 mg daily is safe to administer in combination with gemcitabine and nab-paclitaxel. No unexpected toxicity has been observed. Cytopenias secondary to chemotherapy is common. Preliminary signals of efficacy were observed with this combination. Clinical trial information: NCT02138383.
Optimization Technique for Design of Automotive Air Filter Housings with Improved Fluid Dynamic Performance and Filtration (2004)

A filter housing design technique has been developed that computes the housing geometry required to provide a user-specified velocity distribution through the filter. Appropriate control of the flow field across the filter can improve filter efficiency. Two-dimensional computational designs have been performed specifying a uniform velocity distribution through the filter. This distribution corresponds to a uniform, constant pressure drop across the filter from the upstream to the downstream side. A computational optimization method is used to minimize the variation in the pressure drop along the filter by changing the geometry of the upper wall. Computational fluid dynamics (CFD) calculations of the viscous laminar flow upstream and downstream of the filter are performed using two-dimensional Navier-Stokes equations. As the upper wall profile is numerically changed, the CFD solution for the computations is repeated and the pressure drop variation is reevaluated until an optimum configuration is achieved. The optimization results have produced a pressure distribution that is very close to the specified uniform distribution. Experimental verifications were performed using a laser Doppler anemometer to measure the velocity distribution just upstream of the filter and a pressure transducer to measure pressure drops across the filter. The velocity distribution in this (optimized) housing is more uniform than other housing models having the same fundamental rectangular geometry.
Economic evaluation of ezetimibe treatment in combination with statin therapy in the United States (2017)

Compared with statin monotherapy, ezetimibe with statin therapy was cost-effective for secondary prevention of CHD and stroke and for primary prevention of these conditions in patients whose LDL-C levels are ≥100 mg/dL and in patients with diabetes, taking into account a 90% cost reduction for ezetimibe.
Shape and Uniformity of Pores Contained in Vitrified Bonded CBN Wheels (2006)

The main purpose of this study is to evaluate quantitatively a shape and a uniformity of the pores contained in vitrified bonded cBN wheels. The distributions in the pore size and the distance between adjacent pores are measured and moreover the cross-sectional profile of pores is evaluated using a fractal analysis. The variations in the pore size and the distance between adjacent pores in cBN wheel-U made by newly developed “coating manufacturing method” are smaller than those in cBN wheel-C made by “conventional manufacturing method”, respectively. Fractal dimension calculated for a cross-sectional profile of the pores distributed in cBN wheel-U is larger than that in cBN wheel-C. Such difference in fractal dimension between wheel-U and wheel-C is mainly due to a quality in coating of vitrified bond on the cBN grain. By making the wheel structure uniform, the wheel wear due to shedding and grazing occurred locally on the wheel surface decreases, because an action referred to as “opening phenomenon of chip pocket” occurs uniformly over the wheel working surface.
ChemInform Abstract: Iodotrimethylsilane: A Mild and Efficient Reagent for the Reduction of Azides to Amines. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Results and functional meaning of the detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes. (2016)

The three-dimensional organization of chromosomes of eukaryotic interphase cells is emerging as an important parameter for the regulation of genes as well as the storage, replication and expression of genetic information in general. Whereas a couple of techniques like electrone microscopy (EM), fluorescentce in situ hybridization, or chromosome capture techniques as 3C, 4C, 5C, HiC, or the novel T2C have been used for researching genomic architecture, its dynamics has remained underexplored. Here, we present a novel approach to dissect intramolecular polymer dynamics from fluorescence intensity fluctuations measured with fluorescence correlation spectroscopy (FCS) to investigate the higher order chromatin dynamics in living cells. Using fluorescently tagged linker histone H1 and core histones H2A and H2B as tracer molecules, we found distinct chromatin relaxation times of ~160 ms for open and ~90 ms for dense chromatin areas, corresponding to radii of gyration of 240 and 300 nm for the topologically independent chromatin units. According to their genomic content of ~1 Mb, these domains correspond to subchromosomal domains, already seen by FISH, and histone GFP labelling beforehand and correspond to so called distinct topologically associating domains (TADs). This is an impressive advancements in the field, since details on the dynamic and structural properties of subchromosomal domains/TADs in living cells are scarce.
Based on these results, quantitative analytical and numerical modelling provided access to mass density, persistence length and topological information of chromatin. It allowed to extract these parameters from 3C/5C/HiC/T2C results, to predict chromatin conformation and distance data, and to identify complex looping as crucial for domain formation. Especially, in combination with T2C, a recently developed selective high-throughput high-resolution chromosomal interaction capture technique (see abstract T.A. Knoch & M. Wachsmuth, Determination of the three-dimensional organization of chromatin by modelling-supported selective chromosomal interaction capture (T2C)), which provides very good signal-to-noise ratio, we present a comprehensive systematic approach for the understanding of chromatin dynamics and structure as well as for insight into their impact on gene regulation. As an outlook, we show light-sheet microscopy-based FCS maps of chromatin domain dynamics.
Experimental approaches to NFC-enabled packaging for UX / CX of physical artefacts: A technology maturity study (2023)

Product's packaging with integrated electronic intelligence turns into a visual, tactile and digital encounter with consumers influencing their shopping experience and purchase behavior. The Near Field Communication (NFC) tag attached to the packaging can transform everyday objects into a direct communication channel. However, the NFC technology is still not widely accepted by the industry, thus it is necessary to analyze the influential factors related to consumer behavior, changing needs, and acceptance. As a result, this study carries out the user experiment, where a product's packaging with NFC capabilities is built and tested with selected participants to track user engagement with the smart interactive packaging. The main aim of this study is to examine the peculiarities of the user interaction with NFC-enabled packaging to find out consumer perception and technology acceptance of NFC to retrieve more comprehensive insights regarding barriers to the successful NFC application to a product's packaging. The participants were asked to interact with a set of three NFC-enabled cardboard packages with attached NFC stickers, and afterwards each participant evaluated their experience via survey designed based on Technology Acceptance Model (TAM). According to the results, all three proposed research hypotheses were tested and confirmed to some extent. This study provides a thorough elaboration regarding the technology- and consumer-related barriers that might prevent the successful acceptance of NFC technology applied to the packaging. This research contributes to a better understanding of how different variables have an impact on consumers’ perception and technology acceptance of NFC. All business management practitioners, marketers and designers could employ the results of this research as a way to improve the adoption process of the NFC technology in the packaging industry.
CCDC 825978: Experimental Crystal Structure Determination (2011)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
The Effect of Frontal Air Bags on Eye Injury Patterns in Automobile Crashes (2002)

Using the new injury levels, it was shown that although occupants exposed to an air bag deployment had a higher risk of sustaining minor eye injuries, the air bag appears to have provided a beneficial exchange by reducing the number of severe eye injuries.
Ribosome rescue inhibitors clear <i>Neisseria gonorrhoeae in vivo</i> using a new mechanism (2020)

Abstract The trans -translation pathway for rescuing stalled ribosomes is conserved and essential in bacterial pathogens but has no mammalian homolog, making it an ideal target for new antibiotics. We previously reported the discovery of a family of acylaminooxadiazoles that selectively inhibit trans -translation, resulting in broad-spectrum antibiotic activity. Optimization of the pharmacokinetic and antibiotic properties of the acylaminooxadiazoles produced MBX-4132, which cleared multiple-drug resistant Neisseria gonorrhoeae infection in mice after a single oral dose. Cryo-EM studies of non-stop ribosomes showed that acylaminooxadiazoles bind to a unique site near the peptidyl-transfer center and significantly alter the conformation of ribosomal protein L27, suggesting a novel mechanism for specific inhibition of trans -translation by these molecules. One Sentence Summary Ribosome rescue inhibitors reveal a new conformation of the ribosome and kill drug-resistant Neisseria gonorrhoeae in vivo .
ALPS (1991)

Article Free Access Share on ALPS: an algorithm for pipeline data path synthesis Authors: Ramesh Karri Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CAView Profile , Alex Orailoğlu Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CA Department of Computer Science and Engineering, University of California, San Diego, La Jolla, CAView Profile Authors Info & Claims MICRO 24: Proceedings of the 24th annual international symposium on MicroarchitectureSeptember 1991 Pages 124–132https://doi.org/10.1145/123465.123490Published:01 September 1991Publication History 2citation268DownloadsMetricsTotal Citations2Total Downloads268Last 12 Months2Last 6 weeks1 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteeReaderPDF