gebhart/patrepeval huggingface dataset:
Overexpression of HOX11 Leads to the Immortalization of Embryonic Precursors With Both Primitive and Definitive Hematopoietic Potential (1998)

Primitive and definitive erythropoiesis represent distinct hematopoietic programs that differ with respect to stage of development, transcriptional control, and growth regulation. Although these differences have been recognized for some time, the relationship of the two erythroid lineages to each other is not well established. We have used a model system based on the hematopoietic development of embryonic stem (ES) cells in culture to investigate the origins of the earliest hematopoietic populations. Using ES cells transduced with a retrovirus that overexpresses the HOX11 gene, we have established factor-dependent hematopoietic cell lines that represent novel stages of embryonic hematopoiesis. Analysis of three of these cell lines indicates that they differ with respect to cytokine responsiveness, cell surface markers, and developmental potential. Two of the cell lines, EBHX1 and EBHX11, display the unique capacity to generate both primitive and definitive erythroid progeny as defined by morphology and expression of betaH1 and betamajor globin. The third line, EBHX14, has definitive erythroid and myeloid potential, but is unable to generate cells of the primitive erythroid lineage. Analysis of the cytokine responsiveness of the two lines with primitive erythroid potential has indicated that exposure to leukemia inhibitory factor (LIF) results in the upregulation of betaH1 and a change in cellular morphology to that of primitive erythrocytes. These findings are the first demonstration of a clonal cell line with primitive and definitive hematopoietic potential and support the interpretation that these lineages may arise from a common precursor in embryonic life. In addition, they suggest that LIF could play a role in the regulation of primitive erythropoiesis.
An experimental setup for performance evaluation of spectrum sensing via energy detector (2011)

Spectrum sensing is an essential task for cognitive radios (CRs) and next generation wireless networks (NGWNs). In this study, an experimental setup which can emulate a spectrum sensing scheme through the use of energy detector is proposed. Both line--of--sight (LOS) and non--line--of--sight (NLOS) scenarios are considered. NLOS scenarios take into account the light and heavy shadowing cases as well. The impact of having perfect spectral knowledge on the performance of spectrum sensing is also studied. Results and relevant discussions are given. Conclusions and future directions are outlined.
The Recent Medicinal Chemistry Development of Jak2 Tyrosine Kinase Small Molecule Inhibitors (2010)

Since the discovery of the Jak2-V617F mutation as the causative agent in a large number of myeloproliferative neoplasms (MPNs), there has been a drive to develop Jak2 specific inhibitors that can be used in therapy for MPN patients and other Jak2-related pathologies. Over the past few years, a number of research groups have sought to develop Jak2 tyrosine kinase inhibitors. These compounds are currently in pre-clinical or clinical trials. Unfortunately, there is still a need for more potent, specific, and orally bioavailable drugs to treat these diseases. Within the past twelve months, a variety of medicinal chemistry techniques have produced several lead compounds that exhibit promising Jak2 inhibitory properties. The majority of these inhibitors target the Jak2 kinase domain in general and the ATP-binding pocket in particular. In this review, we summarize these studies and discuss the structure activity relationship (SAR) properties of several compounds. As we learn more about the key structural components that provide potency and specificity in Jak2 inhibition, we will come closer to finding suitable treatment options for individuals suffering from Jak2-mediated pathologies.
MXene‐Bonded Flexible Hard Carbon Film as Anode for Stable Na/K‐Ion Storage (2019)

Abstract Hard carbon (HC) is a promising anode material for sodium‐ion batteries (SIBs) and potassium‐ion batteries (PIBs), but the volume change during the insertion/extraction of Na + or K + limits the cycle life, especially for PIBs due to the large ion size of K + . Moreover, the conventional anodes fabricated through the coating method cannot satisfy the requirement of flexible devices. Here, it is shown that 2D carbide flakes of Ti 3 C 2 T x MXene can be used as multifunctional conductive binders for flexible HC electrodes. The use of MXene nanosheets eliminates the need for all the electrochemically inactive components in the conventional polyvinylidene fluoride–bonded HC electrode, including polymer binders, conductive additives, and current collectors. In MXene‐bonded HC electrodes, conductive and hydrophilic MXene 2D nanosheets construct a 3D network, which can effectively stabilize the electrode structure and accommodate the volume expansion of HC during the charge/discharge process, leading to an enhanced electrode capacity and excellent cycle performance as anodes for both SIBs and PIBs. Benefiting from the 3D conductive network, the MXene‐bonded HC film electrodes also present improved rate capability, indicating MXene is a very promising multifunctional binder for next‐generation flexible secondary rechargeable batteries.
Building a preeminent research lab in the Arab region (2021)

research-article Share on Building a preeminent research lab in the Arab region: the case of QCRI Authors: Ahmed Elmagarmid Hamad Bin Khalifa University, Doha, Qatar Hamad Bin Khalifa University, Doha, QatarView Profile , Abdellatif Saoudi Hamad Bin Khalifa University, Doha, Qatar Hamad Bin Khalifa University, Doha, QatarView Profile Authors Info & Claims Communications of the ACMVolume 64Issue 4April 2021 pp 50–53https://doi.org/10.1145/3447719Online:22 March 2021Publication History 0citation2,061DownloadsMetricsTotal Citations0Total Downloads2,061Last 12 Months314Last 6 weeks26 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my Alerts New Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Reprogramming of the antimycin NRPS-PKS assembly lines inspired by gene evolution (2018)

Reprogramming of the NRPS/PKS assembly line is an attractive method for the production of new bioactive molecules. However, it is usually hampered by the loss of intimate domain/module interactions required for the precise control of chain transfer and elongation reactions. In this study, we first establish heterologous expression systems of the unique antimycin-type cyclic depsipeptides: JBIR-06 (tri-lactone) and neoantimycin (tetra-lactone), and engineer their biosyntheses by taking advantage of bioinformatic analyses and evolutionary insights. As a result, we successfully accomplish three manipulations: (i) ring contraction of neoantimycin (from tetra-lactone to tri-lactone), (ii) ring expansion of JBIR-06 (from tri-lactone to tetra-lactone), and (iii) alkyl chain diversification of JBIR-06 by the incorporation of various alkylmalonyl-CoA extender units, to generate a set of unnatural derivatives in practical yields. This study presents a useful strategy for engineering NRPS-PKS module enzymes, based on nature's diversification of the domain and module organizations.
Improvement in Oxidation Behavior of Nanostructured CoNiCrA1Y Bond Coat Dispersed with Nano-size Alumina Particles (2002)

The oxidation behavior of a nanostructured CoNiCrA1Y bond coat dispersed nano-sized alumina particles was compared to that of a conventional coarse-grained CoNiCrA1Y bond coat. It was found that after a 1000ºC/24 h oxidation a protective alumina layer was developed on the nanostructured coating, whereas a mixed and less protective oxide layer was observed on the conventional coating. Correspondingly, spallation of the oxide layer was not observed with the nanostructured coating but did occur with the conventional coating. The improvement in oxidation behavior observed in the nanostructured coating was suggested to be due to its fine-grained structure, which provides rapid pathways (grain boundaries) for A1 diffusion to form a protective scale of pure alumina. Furthermore, the dispersion of the nano-sized alumina particles was effective in suppressing grain growth and in promoting the rapid formation of a protective alumina scale and thus significantly improving the oxidation resistance of the bond coat.
Fortschrittliche Gasturbinenprozesse mit zweistufiger Verbrennung (1995)

La signification sur le plan economique de l'energie de la turbine a gaz est rapportee par des efforts intensifs de recherches aux grandes ecoles avec la cooperation d'entreprises industrielles et de centres de recherches par calculateurs. Soutenu par des reflexions de base et des developpements technologiques nouveaux, on a presente recemment des concepts futuristes y compris le rechauffage intermediaire. Par une preparation du combustible amelioree et l'influence recherche du processus de combustion, on contrecarre la formation de produits nocifs, de ce fait un posttraitement des gaz de combustion ne s'avere plus necessaire.
Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity (2014)

It has been estimated that 10% of acute liver failure is due to "idiosyncratic hepatotoxicity". The inability to identify such compounds with classical preclinical markers of hepatotoxicity has driven the need to discover a mechanism-based biomarker panel for hepatotoxicity. Seven compounds were included in this study: two overt hepatotoxicants (acetaminophen and carbon tetrachloride), two idiosyncratic hepatotoxicants (felbamate and dantrolene), and three non-hepatotoxicants (meloxicam, penicillin and metformin). Male Sprague-Dawley rats were orally gavaged with a single dose of vehicle, low dose or high dose of the compounds. At 6 h and 24 h post-dosing, blood was collected for metabolomics and clinical chemistry analyses, while organs were collected for histopathology analysis. Forty-one metabolites from previous hepatotoxicity studies were semi-quantified and were used to build models to predict hepatotoxicity. The selected metabolites were involved in various pathways, which have been noted to be linked to the underlying mechanisms of hepatotoxicity. PLS models based on all 41 metabolite or smaller subsets of 6 (6 h), 7 (24 h) and 20 (6 h and 24 h) metabolites resulted in models with an accuracy of at least 97.4% for the hold-out test set and 100% for training sets. When applied to the external test sets, the PLS models predicted that 1 of 9 rats at both 6 h and 24 h treated with idiosyncratic liver toxicants was exposed to a hepatotoxic chemical. In conclusion, the biomarker panel might provide information that along with other endpoint data (e.g., transcriptomics and proteomics) may diagnose acute and idiosyncratic hepatotoxicity in a clinical setting.
Single stage AD-DC full-bridge converter for battery charger (2015)

A single-stage ac-dc converter consisting of full-bridge converter is proposed for EV charger applications. The proposed approach is superior to conventional two-stage ac-dc converter widely used for EV charger applications. The two stage ac-dc converter is apt to be costly and large. However a single-stage ac-dc converter is suitable to a low cost, small volume due to a reduced number of components. The proposed approach achieves the high efficiency from the light load to heavy load conditions. It also achieves the high power factor at the full load condition. In this paper, the feasibility and practical value of the proposed approach are verified by the experimental results from a 0.8kW / 1.6kW products prototype.
Measurement of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mi mathvariant="normal">He</mml:mi><mml:mprescripts/><mml:none/><mml:mn>4</mml:mn></mml:mmultiscripts><mml:mo>(</mml:mo><mml:mover><mml:mi>p</mml:mi><mml:mo></mml:mo></mml:mover><mml:mo>,</mml:mo><mml:mi>n</mml:mi><mml:mo>)</mml:mo></mml:mrow></mml:math>at 100 and<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mn>200</mml:mn><mml:mspace width="0.3em"/><mml:mtext>MeV</mml:mtext></mml:mrow></mml:math>: Analysis with recoil-corrected continuum shell model (2004)

Double-differential cross sections ${d}^{2}\ensuremath{\sigma}∕(d\ensuremath{\Omega}d{E}_{x})$ and spectra of analyzing powers, ${A}_{y}$, for the $^{4}\mathrm{He}(\stackrel{P\vec}{p},n)$ reaction were measured at ${T}_{p}\ensuremath{\approx}100$ and $200\phantom{\rule{0.3em}{0ex}}\text{MeV}$ at forward angles between ${\ensuremath{\theta}}_{lab}=0\ifmmode^\circ\else\textdegree\fi{}$ and $44\ifmmode^\circ\else\textdegree\fi{}$, and were analyzed using wave functions from the recoil-corrected continuum shell model (RCCSM). The steep rise of the cross-section spectra just above the $p+^{3}\mathrm{He}$ rest energy threshold results from the excitation of the ${2}^{\ensuremath{-}}$ and ${1}^{\ensuremath{-}}$ resonances in $^{4}\mathrm{Li}$ and is well reproduced by the RCCSM at both incident energies. At higher excitation energies, the predicted cross sections fall off faster than the experimental values at forward angles. The absolute cross sections from the RCCSM were renormalized by factors of 1.3 and 1.6 at $100\phantom{\rule{0.3em}{0ex}}\text{MeV}$ and $200\phantom{\rule{0.3em}{0ex}}\text{MeV}$, respectively, in order to fit the cross section summed over the lowest $10\phantom{\rule{0.3em}{0ex}}\text{MeV}$ of excitation at the peak of the angular distribution. The $100\phantom{\rule{0.3em}{0ex}}\text{MeV}$ ${A}_{y}$, averaged over the lowest $10\phantom{\rule{0.3em}{0ex}}\text{MeV}$ of excitation, are well reproduced by the RCCSM but not the $200\phantom{\rule{0.3em}{0ex}}\text{MeV}$ ${A}_{y}$, nor are the details of the ${A}_{y}$ spectra well described at either energy.
BIOCHEMICAL CHARACTERIZATION, ANTIPROLIFERATIVE AND CYTOTOXICITY EFFECT OF PURIFIED L-ASPARAGINASE, AN ANTI-LEUKEMIA ENZYME ISOLATED FROM NEW BACTERIA Myroides Gitamensis (2022)

L-asparaginase (L-asp) is used in the treatment of acute lymphocytic leukemia (ALL). L-asp catalyzes the L-asp into ammonia and L-aspartic acid through deamination. The formed ammonia finds to be toxic to the organism. Therefore, the search for less cytotoxic anti-proliferative L-asp is of great importance. Because of its cost effectiveness, consistency, and easiness of process control, microbial L-asparaginase is chosen over plant or animal enzymes. L-asp enzyme which was studied in the article was isolated from a newly discovered bacteria Myroides gitamensis. The biochemical characteristics and anti-proliferative, cytotoxic effect of purified L-asp were studied in order to develop safer biochemically stable anti-leukemia medication. To provide comprehensive information on the characteristics of the isolated L-asparaginase enzyme analytical tools were utilized, including cancer cell lines, brine shrimps, enzyme reactions etc. MOLT-4 and K-562 cell lines showed an IC50 value of 91.41 IU/mL and 77.42 IU/mL, respectively. Cytotoxicity activity of L-asp on Artemia salina showed that at 24 hours (LC50 value of 217.0 µg/mL) and toxic at 48 hours (LC50 value of 126.4µg/ml).
Tunable CW Bi-Doped Fiber Laser System From 1320 to 1370 nm Using a Fiber Bragg Grating (2020)

Here we present a fully fiberized Bi-doped ring laser incorporating a fiber Bragg grating (FBG) operating at a wavelength of 1340nm, which provides 172mW of continuous-wave output power with a slope efficiency of 35%. In addition, we demonstrate a wavelength-tunable version of the laser, which can be tuned from 1320nm to 1370nm by employing a home-made mechanically tunable FBG. Within the whole 50nm tuning band the laser maintains the output power of more than 100mW and the slope efficiency of more than 25%. A maximum output power of ~165mW is achieved over the wavelength range of 1330-1340nm. The linewidth of tunable laser is 0.04nm.
Airspace Diameter Map – a Quantitative Measurement of All Pulmonary Airspaces to Characterize Structural Lung Diseases (2023)

(1) Background: Stereological estimations significantly contributed to our anatomical and physiological understanding of the lung by providing an average distribution of measured parameters over the entire lung parenchyma. However, most structural lung diseases show a very inhomogeneous pattern of alterations. (2) Methods: We developed a novel protocol for the analysis of all pulmonary airspaces. Our pipeline starts with high-resolution synchrotron radiation-based X-ray tomographic microscopy (SRXTM) and consists of (i) image segmentation with the combination of the free machine-learning tool Ilastik and ImageJ and (ii) calculation of the airspace diameter distribution of an entire lung using a diameter map function. To evaluate the new pipeline, lungs from adult mice with cystic fibrosis (CF)-like lung disease (ENaC-transgenic mice) or mice with elastase-induced emphysema were compared to healthy controls. (3) Results: We were able to show the distribution of airspace diameters throughout the entire lung, as well as separately for the conducting airways and the gas-exchange area. In the pathobiological context, we observed an irregular widening of parenchymal airspaces in mice with CF-like lung disease and elastase-induced emphysema. Comparable results were obtained when analyzing lungs imaged with μCT, suggesting that our pipeline is applicable to different kinds of imaging modalities. (4) Conclusions: We conclude that the airspace diameter map is well suited for a detailed analysis of unevenly distributed structural alterations in chronic muco-obstructive lung diseases such as cystic fibrosis and COPD.
Passive acoustic methods of small boat detection, tracking and classification (2017)

Passive acoustic methods can detect, track and classify surface and underwater vessels. We consider the application of these systems for DHS interests with attention to small boats. We present a review of various methods of detection and tracking for low-cost low-power systems with a few hydrophones. The analysis of acoustic signatures of boats to determine their physical parameters (shaft and engine rate, number of propellers and blades, and engine firing rate) is discussed in detail. These parameters can be used for vessel classification. The analysis used acoustic recordings of boats from the Stevens acoustic library.
Three‐dimensional Displacement and Shape Measurement with a Diffraction‐assisted Grid Method (2013)

ABSTRACT The grid method is a full‐field optical technique for computing surface displacements and strains of a material by analyzing the phase of grid lines patterned on the specimen. To date, most experiments using the grid method have measured only two‐dimensional in‐plane deformations. Here, the grid method is extended to three dimensions by using a crossed grid pattern and a diffraction grating which enables acquiring images from multiple viewing angles on a single camera. In‐plane displacements and strains are computed using the conventional grid method, and the corresponding three‐dimensional (3D) displacements—including out‐of‐plane displacements or shapes—are computed by analyzing the images collected at different viewing angles. The technique is demonstrated by measuring 3D rigid body motion, the 3D displacements of a membrane in a pressure‐bulge experiment, and the out‐of‐plane curvature of a cylindrical specimen.
The SH2/SH3 Domain-Containing Protein Nck Is Recognized by Certain Anti-Phospholipase C-γl Monoclonal Antibodies, And Its Phosphorylation on Tyrosine Is Stimulated by Platelet-Derived Growth Factor and Epidermal Growth Factor Treatment (1992)

In the course of our investigation of phospholipase C (PLC)-gamma 1 phosphorylation by using a set of anti-PLC-gamma 1 monoclonal antibodies (P.-G. Suh, S. H. Ryu, W. C. Choi, K.-Y. Lee, and S. G. Rhee, J. Biol. Chem. 263:14497-14504, 1988), we found that some of these antibodies directly recognize a 47-kDa protein. We show here that this 47-kDa protein is identical to the SH2/SH3-containing protein Nck (J. M. Lehmann, G. Riethmuller, and J. P. Johnson, Nucleic Acids Res. 18:1048, 1990). Nck was found to be constitutively phosphorylated on serine in resting NIH 3T3 cells. Platelet-derived growth factor (PDGF) treatment led to increased Nck phosphorylation on both tyrosine and serine. Nck was also found to be phosphorylated on tyrosine in epidermal growth factor (EGF)-treated A431 cells and in v-Src-transformed NIH 3T3 cells. Multiple sites of serine phosphorylation were detected in Nck from resting cells, and no novel sites were found upon PDGF or EGF treatment. A single major tyrosine phosphorylation site was found in Nck in both PDGF- and EGF-treated cells and in v-Src-transformed cells. This same tyrosine was phosphorylated in vitro by purified PDGF and EGF receptors and also by pp60c-src. We compared the phosphorylation of Nck and PLC-gamma 1 in several cell lines transformed by oncogenes with different modes of transformation. Although PLC-gamma 1 and Nck have significant amino acid identity, particularly in their SH3 regions, and both associate with growth factor receptors in a ligand-dependent manner, they were not always phosphorylated on tyrosine in a coincident manner.
HP-65 program computes microstrip impedance (1977)

Reference LEMA-ARTICLE-1977-015View record in Web of Science Record created on 2006-11-30, modified on 2016-08-08
Resolving Self-Assembly of Bile Acids at the Molecular Length Scale (2012)

The self-assembly behavior of the naturally occurring steroidal bile compounds cholic, deoxycholic, ursodeoxycholic, and lithocholic acid was studied by combining atomic force microscopy (AFM), polarized optical microscopy (POM), Fourier-transform infrared spectroscopy (FTIR), absorption spectroscopy (UV-vis), circular dichroism (CD), and wide-angle X-ray scattering (WAXS). Molecular solutions of these mono-, di-, and trihydroxyl substituted bile acids spontaneously evolved into supramolecular aggregates upon the incremental addition of H(2)O as a poor solvent. Highly crystalline nanostructured multilayered assemblies were formed, which revealed a very rich polymorphism of micro- and macro-structures depending on the chemical structure of the bile acid and the properties of the cosolvent (EtOH or DMSO) used. In particular, AFM allowed resolving the crystalline structure to an unprecedented level. It was thus possible to establish that bile acids associate into H-bonded chiral dimer building blocks, which organize in 2D layers of nanostructured lamellar surface topologies with unique facial amphiphilicity. The detailed understanding of the hierarchical organization in bile acid assemblies may contribute to develop strategies to design bioinspired materials with tailor-made nanostructured surface topologies.
Resolution limit for two-dimensional crossed-grating patterns projected by a coherent beam (2003)

The resolution limit for two-dimensional crossed-grating patterns created by projecting mask objects by using a coherent beam has been investigated. We consider first two conventional mask types, a binary-amplitude mask and a two-level phase-shifting mask, in analyzing relationships between a diffraction-beam configuration and an image-intensity distribution. Then we derive, as a mask that overcomes the resolution limit of the conventional ones, a four-level phase-shifting structure with which the minimum image period can be reduced to square root(2)/2 time that of the two-level phase-shifting mask.