gebhart/patrepeval huggingface dataset:
Investigation of the Structure of Platinum Clusters Supported in Zeolite Beta Using the Pair Distribution Function (2007)

Structural characterization of supported metal catalysts is a challenge because the metal clusters are small, usually polydisperse, and present in low loadings. Here, we describe the use of the pair distribution function (PDF) method to study the structure of platinum clusters supported in zeolite beta at a loading of 1.1% w/w. In addition to the characterization by the PDF method, the sample was characterized using X-ray diffraction, X-ray photoelectron spectroscopy, X-ray absorption, and dark-field scanning transmission electron microscopy. With these techniques, we were able to determine that the platinum clusters were in a reduced state, monodisperse, and located mainly in the pores. With the PDF technique, we were able to determine that the local structure of the clusters was similar to that of the bulk platinum. Contrary to what might be expected, the PDF results showed that the lattice parameters did not change significantly. However, attempts to model the PDF using a finite cluster with the bulk platinum structure did not yield quantitative agreement to experiment, and it was determined that there were other interactions besides that of Pt−Pt affecting the PDF. Models that take into consideration different possible cluster shapes and sizes are necessary to completely describe the PDF at these low loadings. However, the PDF technique was shown to be valuable for the experimental determination of the structure of supported nanoclusters.
Implementing p-bits With Embedded MTJ (2017)

Magnetic tunnel junctions (MTJs) utilizing unstable magnets with low barriers have been shown to be well-suited for the implementation of random number generators (RNGs). It has recently been shown that completely new applications involving optimization, inference, and invertible Boolean logic would be enabled if many RNGs can be interconnected to form large scale correlated networks. However, this requires a new device, namely, a three-terminal tunable RNG or a p-bit, whose input terminal can be used to pin its output to 0 or 1. In this letter, we show that a voltage driven p-bit can be implemented simply by incorporating existing RNGs into a transistor circuit using experimentally demonstrated 2-terminal MTJs, without requiring a new device. Using established SPICE models, we show that this proposed p-bit can be interconnected to build correlated p-circuits to implement useful functionalities including a representative example of an invertible AND gate that “factors” the output of an AND gate into consistent input combinations.
ChemInform Abstract: X‐Ray and Spectroscopic Investigations of the Structure of Yttrium Acetate Tetrahydrate (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Parachuting Injuries: A Medical Analysis of an Airborne Operation (1996)

The purpose of this paper is to discuss parachuting variables as they affect support and planning. The authors retrospectively analyzed an operation in which a Ranger battalion parachuted onto an airfield drop zone. Leaders weighed Rangers to estimate the soldiers' load. The advance team failed to adequately coordinate administrative medical assistance on the drop zone. Forty-one Rangers were injured and evacuated from the drop zone (8.6% of the jumpers). Variables in such operations include drop zone selection, equipment weight, drop altitude, wind speed, the wind-flight angle, drop height, and jumper density over the drop zone. Solutions include cargo drops and leaders' repeated emphasis on minimizing the soldiers' loads in accordance with mission accomplishment.
Impact of Hemodynamic Ramp Test-Guided HVAD Speed and Medication Adjustments on Clinical Outcomes (2019)

URL: https://www.clinicaltrials.gov . Unique identifier: NCT03021239.
The assessment of the quality of the graft in an animal model for lung transplantation using the metabolomics <sup>1</sup>H high‐resolution magic angle spinning NMR spectroscopy (2011)

Standards are needed to control the quality of the lungs from nonheart-beating donors as potential grafts. This was here assessed using the metabolomics 1H high-resolution magic angle spinning NMR spectroscopy. Selective perfusion of the porcine bilung block was set up 30 min after cardiac arrest with cold Perfadex®. Lung alterations were analyzed at 3, 6, and 8 h of cold ischemia as compared to baseline and to nonperfused lung. Metabolomics analysis of lung biopsies allowed identification of 35 metabolites. Levels of the majority of the metabolites increased over time at 4°C without perfusion, indicating cellular degradation, whereas levels of glutathione decreased. When lung was perfused at 4°C, levels of the majority of the metabolites remained stable, including levels of glutathione. Levels of uracil by contrast showed a reverse profile, as its signal increased over time in the absence of perfusion while being totally absent in perfused samples. Our results showed glutathione and uracil as potential biomarkers for the quality of the lung. The metabolomics 1H high-resolution magic angle spinning NMR spectroscopy can be efficiently applied for the assessment of the quality of the lung as an original technique characterized by a rapid assessment of intact biopsy samples without extraction and can be implemented in hospital environment.
Development of a Simulator for Ethylene Glycol Loops Based on Solution Thermodynamics and Particle Formation Kinetics (2010)

Abstract This paper presents and discusses the results of a joint industry project to predict precipitation of solids in MEG-systems used for long-distance tie-ins of unprocessed gas directly from subsea wells. Better understanding of the kinetics of dissolution and precipitation reactions in the MEGsystem forms a basis for improved system design and operation.
Noninvasive Imaging of Coronary Arteries: Current and Future Role of Multi–Detector Row CT (2004)

While invasive imaging techniques, especially selective conventional coronary angiography, will remain vital to planning and guiding catheter-based and surgical treatment of significantly stenotic coronary lesions, the comprehensive and serial assessment of asymptomatic or minimally symptomatic stages of coronary artery disease (CAD) for preventive purposes will eventually need to rely on noninvasive imaging techniques. Cardiovascular imaging with tomographic modalities, including computed tomography (CT) and magnetic resonance imaging, has great potential for providing valuable information. This review article will describe the current and future role of cardiac CT, and in particular that of multi-detector row CT, for imaging of atherosclerotic and other pathologic changes of the coronary arteries. It will describe how tomographic coronary imaging may eventually supplement traditional angiographic techniques in understanding the patterns of atherosclerotic CAD development.
Atypical regulators of Wnt/β-catenin signaling as potential therapeutic targets in Hepatocellular Carcinoma (2017)

Hepatocellular carcinoma is one of the most common causes of cancer-related death worldwide. Hepatocellular carcinoma development depends on the inhibition and activation of multiple vital pathways, including the Wnt signaling pathway. The Wnt/β-catenin pathway lies at the center of various signaling pathways that regulate embryonic development, tissue homeostasis and cancers. Activation of the Wnt/β-catenin pathway has been observed frequently in hepatocellular carcinoma. However, activating mutations in β-catenin, Axin and Adenomatous Polyposis Coli only contribute to a portion of the Wnt signaling hyper-activation observed in hepatocellular carcinoma. Therefore, besides mutations in the canonical Wnt components, there must be additional atypical regulation or regulators during Wnt signaling activation that promote liver carcinogenesis. In this mini-review, we have tried to summarize some of these well-established factors and to highlight some recently identified novel factors in the Wnt/β-catenin signaling pathway in hepatocellular carcinoma. Impact statement Early recurrence of human hepatocellular carcinoma (HCC) is a frequent cause of poor survival after potentially curative liver resection. Among the deregulated signaling cascades in HCC, evidence indicates that alterations in the Wnt/β-catenin signaling pathway play key roles in hepatocarcinogenesis. In this review, we summarize the potential molecular mechanisms how the microtubule-associated Protein regulator of cytokinesis 1 (PRC1), a direct Wnt signaling target previously identified in our laboratory to be up-regulated in HCC, in promoting cancer proliferation, stemness, metastasis and tumorigenesis through a complex regulatory circuitry of Wnt3a activities.
Topologically restricted appearance in the developing chick retinotectal system of Bravo, a neural surface protein: experimental modulation by environmental cues. (1990)

A novel neural surface protein, Bravo, shows a pattern of topological restriction in the embryonic chick retinotectal system. Bravo is present on the developing optic fibers in the retina; however, retinal axons in the tectum do not display Bravo. The appearance of Bravo in vitro is modulated by environmental cues. Axons growing out from retinal explants on retinal basal lamina, their natural substrate, express Bravo, whereas such axons growing on collagen do not. Retinal explants provide a valuable system to characterize the mechanism of Bravo restriction, as well as the cellular signals controlling it. Bravo was identified with monoclonal antibodies from a collection generated against exposed molecules isolated by using a selective cell surface biotinylation procedure. The NH2-terminal sequence of Bravo shows similarity with L1, a neural surface molecule which is a member of the immunoglobulin superfamily. This possible relationship to L1, together with its restricted appearance, suggests an involvement of Bravo in axonal growth and guidance.
O1‐05‐04: PROFILING OF INTACT PROTEINS IN THE CSF OF ALZHEIMER’S DISEASE PATIENTS USING TOP DOWN CLINICAL PROTEOMICS (TDCP): A NEW APPROACH GIVING ACCESS TO ISOFORM SPECIFIC INFORMATION OF NEURODEGENERATIVE BIOMARKERS (2016)

Thanks to proteomics investigation, there is a major evolution in our vision of the role of different protein isoforms in the pathophysiology of diseases. The idea that biomarkers like tau, amyloid peptides, ApoE, cystatin, neurogranin… are present in biological fluids as single species is obviously reductionist as most proteins have different isoforms and are subjected to numerous post-translationnal modifications. To have access to this diversity is a major analytical challenge as it necessitates to have specific immunological reagents or to rely on classical mass spectrometry (MS) workflows to detect modified peptides belonging to the biomarkers. A recent breakthrough in MS approaches is represented by the possibility to detect intact proteins in body fluids, and to subsequently identify their composition; an approach that we called top down clinical proteomics (TDCP). We used a last-generation of mass spectrometer (Impact II, Bruker Daltonics) in a TDCP approach with the objective of detecting and afterwards identifying proteoforms in human cerebrospinal fluids (CSF). CSF samples from patients with Alzheimer’s disease (AD), multiple sclerosis (MS) and other non-degenerative disorders (OND) were included. After protein precipitation and SPE extraction, CSF were analyzed by LC-MS using nano-, normal-workflows. Raw data were processed automatically (calibration, compound extraction, charge assessment, peak area determination, and export) prior to statistical analysis. More than 6500 compounds corresponding to intact protein fragments were successfully detected in CSF samples. We could confirm that several isoforms of APP, clusterin or transthyretin were differentially present in the CSF of AD patients. We then focused on the chromogranin/secretogranin synaptic biomarker family which has been recently put forward as possible follow-up biomarkers of neurodegeneration. We were able to selectively follow six different isoforms including the secretogranin-2 fragment (secretoneurin). Interestingly not all isoforms had the same expression profile in the different clinical groups. Top down clinical proteomics (TDCP) is an innovative method that allows us to detect and identify many intact isoforms of biomarkers in human CSF. As a proof of concept, we applied this approach to the chromogranin/secretogranin family. This generated very relevant information to understand the involvement of this class of protein in neurodegeneration and as diagnostic/prognostic biomarkers.
Small UAV Research and Evolution in Long Endurance Electric Powered Vehicles (2007)

This paper describes recent research into the advancement of small, electric powered unmanned aerial vehicle (UAV) capabilities. Specifically, topics include the improvements made in battery technology, design methodologies, avionics architectures and algorithms, materials and structural concepts, propulsion system performance prediction, and others. The results of prototype vehicle designs and flight tests are discussed in the context of their usefulness in defining and validating progress in the various technology areas. Further areas of research need are also identified. These include the need for more robust operating regimes (wind, gust, etc.), and continued improvement in payload fraction vs. endurance.
Foot Abscesses With No Accompanying Wound: Clinical Presentation and Pathogens (2023)

Patients with foot abscess and no wounds had single-pathogen infections, predominantly Staphylococcus and Streptococcus.
Unique features of HLA-mediated HIV evolution in a Mexican cohort: a comparative study (2009)

Our data support universal HLA-mediated HIV evolution at the population level, resulting in detectable HLA-associated footprints in the circulating virus. However, it also strongly suggests that unique genetic backgrounds in different HIV-infected populations may influence HIV evolution in a particular direction as particular HLA-HIV codon associations are determined by specific HLA frequency distributions. Our analysis also suggests a dynamic HLA-associated evolution in HIV with fewer HLA-HIV codon associations observed in the proviral compartment, which is likely enriched in early archived HIV sequences, compared to the plasma virus compartment. These results highlight the importance of comparative HIV evolutionary studies in immunologically different populations worldwide.
Efficient, Low Complexity Encoding of Multiple, Blurred Noisy Downsampled Images Via Distributed Source Coding Principles (2006)

In a portable device, such as a digital camera, limitations on storage are an important consideration. In addition, due to constraints on the complexity of available hardware, image coding algorithms must be fairly simple in implementation. This work presents one such efficient method for coding multiple images of a scene, in a manner that complements a post-processing-based enhancement system. Super-resolution, image restoration and de-noising algorithms have demonstrated the ability to improve the quality of an image using multiple blurry, noisy copies of the same scene. This additional quality does not come without cost, however, since an image capture system must store each image. The proposed encoding scheme is derived from a general linear system model, and encodes multiple images of the same scene, with different amounts of blurring. It is also compared with a variety of methods based on current camera compression technology. For the tested images, this approach requires one-half the rate required by other methods at lower rates. In addition, for a small performance loss, it is essentially implementable without using any compression hardware
Lithium-conducting sulfur compound cathode for lithium-sulfur batteries (2023)

A lithium sulfur cell has a cathode including Li.sub.3PS.sub.4+n(0<n<9), an electrolyte, and an anode comprising lithium. A cathode for a lithium sulfur cell is also disclosed.
Faculty Opinions recommendation of Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates. (2010)

Read the full review for this Faculty Opinions recommended article: Synthesis of acetal protected building blocks using flow chemistry with flow I.R. analysis: preparation of butane-2,3-diacetal tartrates.
Abstract 5681: Metabolic targeting of NRF2 potentiates the efficacy of TRAP1 inhibitor GTPP in colorectal cancer (2022)

Abstract Tumor necrosis factor receptor-associated protein 1 (TRAP1) is a mitochondrial homolog of HSP90 chaperones. It plays an important role in protection against oxidative stress and apoptosis by regulating reactive oxidative species (ROS) and may also exert the cytoprotective activities by regulating mitochondrial permeability transition pore opening. Recent studies have suggested that TRAP1 may regulate metabolism and mitochondrial homeostasis in cancer. To further elucidate the mechanistic role of TRAP1 in regulating tumor cell survival, we used cellular models to investigate cellular effects and signaling pathways regulated by TRAP1 in several colon cancer cell lines. Inhibition of TRAP1 by a small molecule inhibitor, Gamitrinib-triphenylphosphonium (GTPP), in colon cancer cells led to ROS production, ER stress, reduction of cell viability and induction of cell death. Interestingly, we observed wide-range of responses to TRAP1 inhibition among these colon cancer cell lines. In GTPP sensitive cell lines (SW48), GTPP induced upregulation of GRP78, CHOP and cleavage form PARP proteins. In contract, in GTPP resistant cells (DLD1 and RKO), GTPP treatment highly induced activation of antioxidant gene NRF2, leading to better cell survival under oxidative environment. NRF2 target genes HO1 and NQO1 were upregulated in GTPP-treated DLD1 cells, making these cells more resistant to GTPP treatment. Using reporter assay, we further found that transcriptional activation of antioxidative responds element (ARE) was increased in GTPP-treated DLD1 and RKO cells (GTPP resistant), but not in SW48 cells (GTPP sensitive). Combination of NRF2 inhibitor ML385 and GTPP led to excessive ROS production and exacerbated GTPP-induced cell death in GTPP resistant cells. These new findings for the first-time link TRAP1 and NRF2 in a common pathway regulating ROS production in colon cancer. Taken together, dual targeting of TRAP1 and NRF2 may potentially overcome the tumor cell resistance through disruption of mitochondrial redox homeostasis. Citation Format: Hong-Yuan Tsai, Ru Chen, Noah Shroyer, Sheng Pan. Metabolic targeting of NRF2 potentiates the efficacy of TRAP1 inhibitor GTPP in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5681.
The Emergence of Aqueous Ammonium‐Ion Batteries (2021)

Aqueous ammonium-ion (NH<sub>4</sub> <sup>+</sup> ) batteries (AAIB) are a recently emerging technology that utilize the abundant electrode resources and the fast diffusion kinetics of NH<sub>4</sub> <sup>+</sup> to deliver an excellent rate performance at a low cost. Although significant progress has been made on AAIBs, the technology is still limited by various challenges. In this Minireview, the most recent advances are comprehensively summarized and discussed, including cathode and anode materials as well as the electrolytes. Finally, a perspective on possible solutions for the current limitations of AAIBs is provided.
Hierarchical Domains for Decentralized Administration of Spatially-Aware RBAC Systems (2008)

Emerging models for context-aware role-based access control pose challenging requirements over policy administration. In this paper we address the issues raised by the decentralized administration of a spatially-aware access control model in a mobile setting. We present GEO-RBAC Admin, the administration model for the GEO-RBAC model. The model is based on the notion of hierarchy of spatial domains; a spatial domain is an entity grouping objects based on organizational and spatial proximity criteria. In the paper we formally define the model and introduce and prove relevant properties.
Organolanthanide-Catalyzed Intramolecular Hydroamination/Cyclization of Amines Tethered to 1,2-Disubstituted Alkenes (2001)

[reaction: see text] This contribution reports the organolanthanide-catalyzed intramolecular hydroamination/cyclization of amines tethered to 1,2-disubstituted alkenes to afford the corresponding mono- and disubstituted pyrrolidines and piperidines by using coordinatively unsaturated complexes of the type (eta(5)-Me(5)C(5))(2)LnCH(TMS)(2) (Ln = La, Sm), [Me(2)Si(eta(5)-Me(4)C(5))(2)]NdCH(TMS)(2), [Et(2)Si(eta(5)-Me(4)C(5))(eta(5)-C(5)H(4))]NdCH(TMS)(2), and [Me(2)Si(eta(5)-Me(4)C(5))((t)()BuN)]LnE(TMS)(2) (Ln = Sm, Y, Yb, Lu; E = N, CH) as precatalysts. [Me(2)Si(eta(5)-Me(4)C(5))((t)BuN)]LnE(TMS)(2) mediates intramolecular hydroamination/cyclization of sterically demanding amino-olefins to afford disubstituted pyrrolidines in high diastereoselectivity (trans/cis = 16/1) and in good to excellent yield.
Design of a portable near infrared system for topographic imaging of the brain in babies (2004)

A portable topographic near-infrared spectroscopic (NIRS) imaging system has been developed to provide real-time temporal and spatial information about the cortical response to stimulation in unrestrained infants. The optical sensing array is lightweight, flexible, and easy to apply to infants ranging from premature babies in intensive care to children in a normal environment. The sensor pad consists of a flexible double-sided circuit board onto which are mounted multiple sources (light-emitting diodes) and multiple detectors (p-i-n photodiodes), all electrically encapsulated in silicone rubber. The control electronics are housed in a box with a medical grade isolated power supply and linked to a PC fitted with a data acquisition card, the signal acquisition and analysis being performed using LABVIEW™. The signal output is displayed as an image of oxy- and deoxyhemoglobin concentration ([HbO2], [Hb]) changes at a frame rate of 3 Hz. Experiments have been conducted on phantoms to determine the sensitivity of the system, and the results have been compared to theoretical simulations. The system has been tested in volunteers by imaging changes in forearm muscle oxygenation, following blood pressure cuff occlusion to obtain typical [Hb] and [HbO2] plots.
Chemical modification studies of gelonin (1985)

Gelonin inhibits protein synthesis by inactivating the eukaryotic 60 S ribosomal subunit by an unknown mechanism. The protein was purified in high yield by a new method using Cibacron blue F 3 GA‐Sepharose. Chemical modification studies reveal that arginine residues are essential for biological activity.