gebhart/patrepeval huggingface dataset:
Probes for Narcotic Receptor Mediated Phenomena (2003)

Abstract The synthesis of a series of epoxy 5‐phenylmorphans is being explored in order to determine the conformational requirements of the phenolic ring in a phenylmorphan molecule that may be needed both for binding to a specific opioid receptor and for exhibiting opioid agonist or antagonist activity. Of the twelve possible ortho ‐ and para ‐bridged isomers (a–f) ( Fig. 1 ), we now report the synthesis of the para ‐d isomer, rac ‐(3 R ,6a S ,11a R )‐2‐methyl‐1,3,4,5,6,11a‐hexahydro‐2 H ‐3,6a‐methanobenzofuro[2,3‐ c ]azocin‐8‐ol ( 3 ). Compound 3 was synthesized via construction of the 5‐phenylazabicyclo[3.3.1]non‐3‐ene skeleton ( Scheme 1 ) and subsequent closure of the epoxy bridge ( Scheme 2 ). As determined by an X‐ray diffraction study, the epoxy bridge, restricting the phenyl‐ring rotation, fixed the dihedral angle between the least‐squares planes through the phenyl ring and atoms N(2), C(3), C(11a), and C(6a) of the piperidine ring ( Fig. 2 ) at 43.0°, and the torsion angle C(12)C(6a)C(6b)C(10a) at −95.0°.
Supplementary Data from Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non–Small Cell Lung Cancer (2023)

Supplementary Data from Phase I Study of Taminadenant (PBF509/NIR178), an Adenosine 2A Receptor Antagonist, with or without Spartalizumab (PDR001), in Patients with Advanced Non–Small Cell Lung Cancer
Radio over fiber network technologies for linear cell systems in millimeter-wave bands (2017)

Millimeter-wave signal feeding technique to remote radio transceivers via an optical fiber network is discussed particularly in linear cell configurations using radio over fiber technologies. Double-sideband and single-sideband modulation schemes with suitable modulation frequency are demonstrated under 10-km-class optical fiber network configuration.
Effect of Nanoparticle Biophysicochemical Properties on Binding and Transport across Cardiovascular Endothelial Dysfunction Models (2021)

Cardiovascular disease remains the number one cause of mortality and morbidity worldwide and includes atherosclerosis, which presents as a deadly and chronic inflammatory disease. The initial pathological factor in atherosclerosis is a dysfunctional endothelium (Dys-En), which results in enhanced permeability of the endothelium and enhanced expression of adhesion molecules such as vascular cell adhesion molecule 1 (VCAM-1), among others. Nanomedicines represent a growing arsenal of novel therapeutics aimed at treating atherosclerosis; however, nanoparticle (NP) interactions as a function of their biophysiochemical properties with the Dys-En are not currently well understood. In this study, we investigated targeted NP biophysicochemical properties for maximal VCAM-1 binding and permeability across several Dys-En models that we established using cardiovascular inflammatory mediators. We found that NP size governs permeability and binding, regardless of the type and density of VCAM-1 peptide ligand used. Our results suggest that the design of NPs in the range of 30–60 nm can highly increase permeability and binding across the Dys-En. These findings confirm the importance of in vitro models of Dys-En as a preliminary screening and predictive tool for atherosclerosis NP targeting.
Automated segmentation of the pulmonary arteries in low-dose CT by vessel tracking (2011)

We present a fully automated method for top-down segmentation of the pulmonary arterial tree in low-dose thoracic CT images. The main basal pulmonary arteries are identified near the lung hilum by searching for candidate vessels adjacent to known airways, identified by our previously reported airway segmentation method. Model cylinders are iteratively fit to the vessels to track them into the lungs. Vessel bifurcations are detected by measuring the rate of change of vessel radii, and child vessels are segmented by initiating new trackers at bifurcation points. Validation is accomplished using our novel sparse surface (SS) evaluation metric. The SS metric was designed to quantify the magnitude of the segmentation error per vessel while significantly decreasing the manual marking burden for the human user. A total of 210 arteries and 205 veins were manually marked across seven test cases. 134/210 arteries were correctly segmented, with a specificity for arteries of 90%, and average segmentation error of 0.15 mm. This fully-automated segmentation is a promising method for improving lung nodule detection in low-dose CT screening scans, by separating vessels from surrounding iso-intensity objects.
Deterministic downlink transmission in WirelessHART networks enabling wireless control applications (2010)

Wireless sensor and actuator networks bring many benefits to industrial automation systems. However, unreliable wireless and multihop communications among sensors and actuators cause challenges in designing such systems. Wireless HART is the first standard for wireless real-time industrial applications. However, current Wireless HART standard does not provide services for efficient usage of actuators, which are an essential part of automation. In this paper we focus on Wireless HART and propose a periodic and deterministic downlink transmission functionality which enables efficient usage of actuators and control applications. Furthermore, we define new HART commands extending the interface, without affecting available services, to support the integration of actuators. This can be achieved with minor changes in the current standard.
Diffusion-influenced excited-state reversible transfer reactions, A*+B⇌C*+D, with two different lifetimes: Theories and simulations (2005)

We report accurate Brownian simulation results for the kinetics of the pseudo-first-order diffusion-influenced excited-state reversible transfer reaction A(*) + Bright harpoon over left harpoonC(*) + D with two different lifetimes using two different propagation algorithms. The results are used to test approximate solutions for this many-particle problem. Available theories fail when one of the two reactions or (decay) rate constants is large. To remedy this situation, we develop two uniform approximations, which are based on introducing a generalized Smoluchowski term into the relaxation-time approximation. The best of these is the extended unified theory of reversible target reactions, which reduces correctly in all limits and exhibits superior agreement with simulations.
A stress-strain framework for modelling the behaviour of unsaturated soils under non-isothermal conditions (2007)

Summary. This paper addresses a new, unified thermo-mechanical constitutive model for unsaturated soils through a coupled study. In the context of elastoplasticity and the critical state theory, the model uses the concepts of multimechanism and bounding surface theory. This advanced constitutive approach involves thermo-plasticity of saturated and unsaturated soils. Bishop’s effective stress framework is adopted to represent the stress state in the soil. This stress is linked to the water retention curve, which is represented by an elasto-plastic model. Attention is focused particularly on the coupling relations inferred from this unified thermohydro-mechanical (THM) study. Finally, the theoretical aspects of the paper are supported by comparisons between numerical simulations and experimental results. Key words: unsaturated soils, thermo-mechanics, constitutive modelling, elastoplasticity, multi-mechanism
FGF–FGFR Signaling Mediated through Glycosaminoglycans in Microtiter Plate and Cell-Based Microarray Platforms (2013)

Fibroblast growth factor (FGF) signals cell growth through its interaction with a fibroblast growth factor receptor (FGFR) and a glycosaminoglycn (GAG) coreceptor. Here, we examine the signaling of five different FGFs (1, 2, 6, 8, and 8b) through FGFR3c. A small library of GAG and GAG-derivative coreceptors are screened to understand better the structure-activity relationship of these coreceptors on signaling. Initially, data were collected in a microtiter plate well-based cell proliferation assay. In an effort to reduce reagent requirements and improve assay throughput, a cell-based microarray platform was developed. In this cell-based microarray, FGFR3c-expressing cells were printed in alginate hydrogel droplets of ∼30 nL and incubated with FGF and GAG. Heparin was the most effective GAG coreceptor for all FGFs studied. Other GAGs, such as 2-O-desulfated heparin and chondroitin sulfate B, were also effective coreceptors. Signaling by FGF 8 and FGF 8b showed the widest tolerance for coreceptor structure. Finally, this on-chip cell-based microarray provides comparable data to a microtiter plate well-based assay, demonstrating that the coreceptor assay can be converted into a high-throughput assay.
1071 (2015)

Copyright © by 2015 by the Society of Critical Care Medicine and Wolters Kluwer Health, Inc. All Rights Reserved.
Solid-State Polymorphic Transition and Solvent-Free Self-Assembly in the Growth of Organic Crystalline Microfibers (2007)

The study of the crystalline xerogel formed by a newly synthesized l-valine and pyridine containing low-molecular-weight gelator reveals a polymorphic transition above 225 °C that is followed by the formation of microfibers. The habitus of the fibers grown remains stable upon cooling. Microscopic observations lead to the suggestion that after the polymorphic transition, the fibers are formed by a sublimation process. Results obtained reveal the intrinsic tendency of this compound to self-assemble anisotropically in fibers that permit the preparation of organic crystalline micro- and nanofibers in solvent-free conditions.
Mesenchymal stem cell migration in a murine model of myocardial infarction (2012)

Aims: Mesenchymal stem cell (MSC)-based therapies are presently under investigation for the treatment of myocardial infarction (MI). However, for MSCs to regenerate the wounded myocardium, tissue specific homing is crucial. We sought out to determine whether amplifying the cytokine signals released by the ischemic myocardium can enhance the recruitment of intravenously (IV) administered bone marrow-derived MSCs.
Emergency Preparedness for Facilities : A Guide to Safety Planning and Business Continuity (2003)

Emergency Preparedness for Facilities A Guide to Safety Planning and Business Continuity , Emergency Preparedness for Facilities A Guide to Safety Planning and Business Continuity , کتابخانه الکترونیک و دیجیتال - آذرسا
Conductivity of Oriented Samaria-Doped Ceria Thin Films Grown by Oxygen-Plasma-Assisted Molecular Beam Epitaxy (2008)

We have used oxygen-plasma-assisted molecular beam epitaxy to grow highly oriented Ce1-xSmxO2-delta films on single-crystal c-Al2O3. The samarium concentration x was varied in the range of 1-33 atom %. It was observed that dominant (111) orientation in Ce1-xSmxO2-delta films can be maintained up to about 10 atom % samarium concentration. Films higher than 10 atom % Sm concentration started to show polycrystalline features. The highest conductivity of 0.04 S cm(-1) at 600 degrees C was observed for films with similar to 5 atom % Sm concentration. A loss of orientation, triggering an enhanced grain-boundary scattering, appears to be responsible for the decrease in conductivity at higher dopant concentrations. (c) 2008 The Electrochemical Society.
Long-Term Follow-up of Recurrent Laryngeal Nerve Avulsion for the Treatment of Spastic Dysphonia (1996)

Long-term follow-up of 3 to 7 years is reported on 18 patients who had undergone recurrent laryngeal nerve avulsion (RLNA) for the treatment of adductor spastic dysphonia (SD). Data on neural regrowth after previous recurrent laryngeal nerve section (RLNS) are presented in 2 of these 18 patients. We introduced RLNA as a modification of standard RLNS to prevent neural regrowth to the hemiparalyzed larynx and subsequent recurrence of SD. We have treated a total of 22 patients with RLNA, and now report a 3- to 7-year follow-up on 18 of these 22 patients. Resolution of symptoms was determined by routine follow-up assessment, perceptual voice analysis, and patient self-assessment. Sixteen of 18, or 89%, had no recurrence of spasms at 3 years after RLNA as determined at routine follow-up. Two of the 16 later developed spasms after medialization laryngoplasty for treatment of weak voice persistent after the avulsion. This yielded a total of 14 of 18, or 78%, who were unanimously judged by four speech pathologists to have no recurrence of SD at the longer follow-up period of 3 to 7 years. Two of these 4 patients were judged by all four analysts to have frequent, short spasms. The other 2 were judged by two of four analysts to have seldom, short spasms. Three of 18 patients presented with recurrent SD after previous RLNS. At the time of subsequent RLNA, each patient had evidence of neural regrowth at the distal nerve stump as demonstrated by intraoperative electromyography and histologic evaluation of the distal nerve stump. One remained free of SD following RLNA, 1 was free of spasms at 4 years after revision avulsion but developed spasms after medialization laryngoplasty, and the final patient developed spasms 3.75 years after revision RLNA. Medialization laryngoplasty with Silastic silicone rubber was performed in 6 of 18, with correction of postoperative breathiness in all 6, but with recurrence of spasm in 3. Spasms resolved in 1 of these with downsizing of the implant. We conclude that RLNA represents a useful treatment in the management of SD in patients not tolerant of botulinum toxin injections.
Modeling the Impact of Climatological Factors and Technological Revolution on Soybean Yield: Evidence from 13-Major Provinces of China (2022)

In recent years, the changing climate has become a major global concern, and it poses a higher threat to the agricultural sector around the world. Consequently, this study examines the impact of changing climate and technological progress on soybean yield in the 13 major provinces of China, and considers the role of agricultural credit, farming size, public investment, and power of agricultural machinery from 2000 to 2020. Fully modified ordinary least squares (FMOLS) and dynamic ordinary least squares (DOLS) are applied to assess the long-run effect, while Dumitrescu and Hurlin's (2012) causality test is used to explore the short-run causalities among the studied variables. The results revealed that an increase in the annual mean temperature negatively and significantly affects soybean yield, while precipitation expressively helps augment soybean yield. Furthermore, technological factors such as chemical fertilizers accelerate soybean yield significantly, whereas pesticides negatively influence soybean yield. In addition, farming size, public investment, and power of agricultural machinery contribute remarkably to soybean yield. The causality results endorse that chemical fertilizers, pesticides used, agricultural credit, public investment, and power of agricultural machinery have bidirectional causality links with soybean yield. This study suggests several fruitful policy implications for sustainable soybean production in China.
ChemInform Abstract: Studies on ABX6 Compounds. Part 2. The BaThBr6 Structure Type. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
HOST PLANT INFLUENCES ON SEX PHEROMONE BEHAVIOR OF PHYTOPHAGOUS INSECTS (1997)

The sexual behavior of phytophagous insects is often integrated in a variety of ways with their host plants. This integration may be manifested as effects or influences of host plants on insect physiology and behavior, including sex pheromone communication, that reflect strategies by insects to optimize mating and reproduction. Certain insects sequester or otherwise acquire host plant compounds and use them as sex pheromones or sex pheromone precursors. Other insects produce or release sex pheromones in response to particular host plant cues. Chemicals from host plants often synergize or otherwise enhance insect responses to sex pheromones. By these means, host plants may be used by insects to regulate or mediate sexual communication. For many species of insects, host plant influences on insect sex pheromone communication may be important aspects of the formation of feeding and mating aggregations, of insect strategies to locate both hosts and mates, of behavioral reproductive isolation among sibling species, and of the regulation of reproduction to coincide with the availability of food and oviposition sites. Knowledge of these relationships is critical to understanding many different areas of the behavioral ecology of plant-feeding insects.
Early detection of variants of concern via funnel plots of regional reproduction numbers (2023)

Early detection of the emergence of a new variant of concern (VoC) is essential to develop strategies that contain epidemic outbreaks. For example, knowing in which region a VoC starts spreading enables prompt actions to circumscribe the geographical area where the new variant can spread, by containing it locally. This paper presents 'funnel plots' as a statistical process control method that, unlike tools whose purpose is to identify rises of the reproduction number ([Formula: see text]), detects when a regional [Formula: see text] departs from the national average and thus represents an anomaly. The name of the method refers to the funnel-like shape of the scatter plot that the data take on. Control limits with prescribed false alarm rate are derived from the observation that regional [Formula: see text]'s are normally distributed with variance inversely proportional to the number of infectious cases. The method is validated on public COVID-19 data demonstrating its efficacy in the early detection of SARS-CoV-2 variants in India, South Africa, England, and Italy, as well as of a malfunctioning episode of the diagnostic infrastructure in England, during which the Immensa lab in Wolverhampton gave 43,000 incorrect negative tests relative to South West and West Midlands territories.
Multi-photon attenuation-compensated light-sheet fluorescence microscopy (2019)

Attenuation of optical fields owing to scattering and absorption limits the penetration depth for imaging. Whilst aberration correction may be used, this is difficult to implement over a large field-of-view in heterogeneous tissue. Attenuation-compensation allows tailoring of the maximum lobe of a propagation-invariant light field and promises an increase in depth penetration for imaging. Here we show this promising approach may be implemented in multi-photon (two-photon) light-sheet fluorescence microscopy and, furthermore, be achieved in a facile manner utilizing a graded neutral density filter, circumventing the need for complex beam shaping apparatus. A “gold standard” system utilizing a spatial light modulator for beam shaping is used to benchmark our implementation. The approach will open up enhanced depth penetration in light-sheet imaging to a wide range of end users.
Prognostic significance of tumor-infiltrating CD8+ and FOXP3+ lymphocytes in residual tumors and alterations in these parameters after neoadjuvant chemotherapy in triple-negative breast cancer: a retrospective multicenter study (2015)

This is the first study to demonstrate that high CD8(+) TIL and a high CD8/FOXP3 ratio in residual tumors and increment of these parameters following NAC and accurately predict improved prognosis in TNBC patients with non-pathological complete response following NAC. These parameters could serve as a surrogate one for adjuvant treatment in patients with residual disease in the neoadjuvant setting.
Immobilization of Nanostructured Lipid Particles in Polysaccharide Films (2011)

Lipid-based equilibrium self-assemblies and their hierarchically ordered forms have been known since the last few decades. Related progress in colloids and interface science led the development of oil-in-water type internally self-assembled lipid particles, known as Isasomes, which have aroused great interest in biotechnological applications. These submicrometer-sized lipid particles are internally nanostructured in a form of various liquid-crystalline or microemulsion phases, which facilitate their loading with hydrophilic, hydrophobic, and amphiphilic molecules. Their internal nanostructure can also be finely tuned. Recently, it has been shown that Isasomes can be entrapped in thermoreversible polysaccharide hydrogels. Herein, we report on the immobilization of Isasomes in solid polysaccharide films prepared by drying particle-loaded κ-carrageenan and methyl cellulose-based hydrogels. These rather simple but elegant media facilitate the storage of these functional particles and their subsequent release by simple resolubilization in water and/or thermal transitions. Systematic rehydration studies of such Isasome-loaded films have shown that the Isasomes can be remobilized and/or recovered after resolubilization of loaded films, even after several months.
Blue-enhanced thin-film photodiode for dual-screen x-ray imaging (2009)

This article reports on a-Si:H-based low-leakage blue-enhanced photodiodes for dual-screen x-ray imaging detectors. Doped nanocrystalline silicon was incorporated in both the n- and p-type regions to reduce absorption losses for light incoming from the top and bottom screens. The photodiode exhibits a dark current density of 900 pA/cm2 and an external quantum efficiency up to 90% at a reverse bias of 5 V. In the case of illumination through the tailored p-layer, the quantum efficiency of 60% at a 400 nm wavelength is almost double that for the conventional a-Si:H n-i-p photodiode.
Abstract P12 (2014)

AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK AMERICAN SOCIETY OF PLASTIC SURGEONS PLASTIC & RECONSTRUCTIVE SURGERY PRS GLOBAL OPEN ASPS EDUCATION NETWORK
Comparing expression profiles of genes with similar promoter regions (2002)

We use the data sets from experiments on Saccharomyces cerevisiae. Our similarity measure for the promoter regions is based on the set of common mapped or putative transcription factor binding sites and other regulatory elements in the upstream region of the genes, as contained in the Saccharomyces cerevisiae Promoter Database. We pair up the genes with high similarity scores and compare their expression levels in time-course experiment data. We find that genes with similar promoter regions on the average have significantly higher correlation, but it can vary widely depending on the genes. This confirms that the presence of similar regulatory elements often does not correspond to similarity in expression profiles and indicates that finding transcription factor binding sites or other regulatory elements starting with the expression patterns may be limited in many cases. Regardless of the correlation, the degree to which the profiles agree under different experimental conditions can be examined to derive hypotheses concerning the role of common regulatory elements. Overall, we find that considering the relationship between the promoter regions and the expression profiles starting with the regulatory elements is a difficult but useful process that can provide valuable insights.
Pupillary responses to emotionally provocative stimuli (2000)

This paper investigated in two experiments pupillary responses to emotionally provocative sound stimuli. In experiment one, 30 subjects' pupillary responses were measured while listening to 10 negatively and 10 positively arousing sounds, and 10 emotionally neutral sounds. In addition, the subjects rated their subjective experiences to these stimuli. The results showed that the pupil size was significantly larger after highly arousing positive and negative stimuli than after neutral stimuli with medium arousal.