gebhart/patrepeval huggingface dataset:
Inkjet printing of elastomeric optical waveguides (2016)

Optical waveguides transmit light in a controlled manner,1 making its propagation possible over long distances, with only little and predictable loss. This gives a great advantage for optoelectronics and in wavelength sensitive biological systems,2 allowing fast information transfer without electromagnetic interference.3 Typically, optical elements (e.g. printed optical circuit boards) are not required to be flexible or stretchable. However, elasticity and stretchability expand the field of waveguide application. Recent efforts focus on creating fully elastic systems, able to withstand complex deformation (stretching, twisting, bending).4,5The goal of the research was to develop a system that is compatible with an inkjet printing process and allows the fabrication of elastomeric waveguides, employing commercially available products. For that purpose the system has the following requirements:1. The ink should compromise good printing properties and high substrate wettability. It should be chemically stable and photocurable.2. The ink should have good elastomeric properties after curing, and the mechanical properties of the ink should match the ones of the cladding, to avoid delamination at the waveguide/cladding interface at higher strains.3. The cladding should have a lower refractive index than the cured ink, and this difference should be possibly big.4. The printed channel should be homogenous, with stable contact lines, stable cross section along the long axis and possibly big contact angle. Bulge formation has to be avoided.6The first three requirements are met by optimising the composition of polyurethane acrylate inks, and using PDMS as a substrate and the cladding material. Requirement 4 poses a difficult problem to overcome, since the stability of printed channels decreases for high contact angles.6 The contact angle can be adjusted by modifying the surface energy and viscosity of both the ink and the substrate. A method which allowed us to obtain homogenous lines with a high contact angle (see Fig. 1) is described. All structures were fabricated with a standard laboratory printer (Dimatix DMP-2831), with an attached LED lamp (Omni Cure LED, Series 1000). &lt;fig position="float" id="s48_f.1"&gt; &lt;label&gt;Figure 1&lt;/label&gt; &lt;caption&gt;LEFT: A typical cross section of the printed waveguides; RIGHT: the top view of the printed waveguides&lt;/caption&gt; &lt;graphic mime-subtype="tif" xlink:href="Images\s48_f01.tif" xmlns:xlink="http://www.w3.org/1999/xlink"/&gt; &lt;/fig&gt;
Automated segmentation and quantification of airway mucus with endobronchial optical coherence tomography (2020)

We propose a novel suite of algorithms for automatically segmenting the airway lumen and mucus in endobronchial optical coherence tomography (OCT) data sets, as well as a novel approach for quantifying the contents of the mucus. Mucus and lumen were segmented using a robust, multi-stage algorithm that requires only minimal input regarding sheath geometry. The algorithm performance was highly accurate in a wide range of airway and noise conditions. Mucus was classified using mean backscattering intensity and grey level co-occurrence matrix (GLCM) statistics. We evaluated our techniques in vivo in asthmatic and non-asthmatic volunteers.
Synthesis and Properties of Methylthiopyrazolo[3,4‐<i>d</i>]pyrimidine 2′‐Deoxy‐β‐<scp>D</scp>‐ribonucleosides (1992)

Abstract The synthesis of the 3‐ and 4‐(methylthio)pyrazolo[3,4‐ d ]pyrimidine N 1 ‐ and N 2 ‐2′‐deoxy‐β‐ D ‐ribonucleosides 2b, 15 is described. Anionic glycosylation of 5‐amino‐3‐(methylthio)‐4‐pyrazolecarbonitrile ( 4 ) or 4‐(methylthio)pyrazolo[3,4‐ d ]pyrimidine ( 12 ) with 2‐deoxy‐3,5‐di‐ O ‐(4‐methylbenzoyl)‐α‐ D ‐ erythro ‐pentofuranosyl chloride ( 5 ) gave the regioisomeric N 1 ‐and N 2 ‐nucleosides 6 , 7 , 13 , and 14 . The N 1 isomer was the main product in the reaction of 12 , and the N 2 compound was the preferred product in the glycosylation of 4 . Glycosylation in suspension ( 12 ) yielded an appreciable amount of the N 2 α‐ D ‐isomer 16 . 4‐Aminopyrazolo[3,4‐ d ]pyrimidine 2′‐deoxyribonucleosides 3a , b with a methylthio group at C‐3 are resistant to deamination by adenosine deaminase and inhibit the proliferation of leukemia cell lines.
Exercise and risk of injurious fall in home-dwelling elderly (2008)

Habitual physical exercise proved to be safe and some of the exercises were associated with reduced risk of subsequent fall-related injury. Female sex, an injury-causing fall in the recent past and problems with near vision increased the risk.
CICE output from Global Ocean Forecast System (GOFS) 3.1 for 2018052112 (2018)

INITIALIZATION: 2018052112\n\nFORECASTS:\n12-hrly out to 7.5 days (t180)\n\nGRIDS:\nARCu0.08 -- poleward of 40N\nANTu0.08 -- poleward of 49.52S\n\nPARAMETERS:\nhi:standard_name = "sea_ice_thickness" ;\nhs:standard_name = "surface_snow_thickness" ;\nTsfc:standard_name = "surface_temperature_where_sea_ice" ;\naice:standard_name = "sea_ice_area_fraction" ;\nuvel:standard_name = "eastward_sea_ice_velocity" ;\nvvel:standard_name = "northward_sea_ice_velocity" ;\nsst:standard_name = "sea_water_temperature" ;\nuocn:standard_name = "eastward_sea_water_velocity" ;\nvocn:standard_name = "northward_sea_water_velocity" ;\nTair:standard_name = "air_temperature" ;\nstrength:standard_name = "compressive_strength_of_sea_ice" ;
Sensor-Based Frailty Assessment in Survivors of Childhood Cancer: A Pilot Study (2021)

Results from this study support higher risk for frailty among CCS, especially those with multiple comorbidities or who were treated with RT. A wrist-worn sensor-based method is feasible for application in AYA CCS, and provides an opportunity for cost-effective, rapid screening of at-risk AYA CCS who may benefit from early interventions.
Crystalline Polymers in Nanoscale 1D Spatial Confinement (2006)

A series of semicrystalline block copolymers, poly(4-vinylpyridine)-block-poly(ε-caprolactone) (P4VP−PCL), with lamellar microstructure have been synthesized. Owing to the vitrified P4VP microdomains and strongly segregated microphase separation, the crystallization of the PCL blocks in P4VP−PCL was carried out within the nanoscale confinement. Simply by varying the molecular weight of the block copolymer, namely the confined size, polymeric crystallization can be tailored in the one-dimensional confinement. A distinct nucleation mechanism, altering from heterogeneous to homogeneous nucleation, was obtained once the confined size became smaller than a critical dimension, equivalent to the regular thickness of heterogeneously nucleated crystalline lamellae. Consequently, discrete crystalline granules were generated through homogeneous nucleation, namely a single nucleus within one granule. Also, crystal growth was altered from specific to random orientation with respect to the interface between the crystalline and amorphous domains in the copolymers. This system thus serves as a model to analyze the impact of confined size in 1D spatial confinement on the crystallization of polymers.
The effect of droplet extension on the rheology of emulsions of water in alkyd resin (2001)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation M. J. Thompson, J. R. A. Pearson, M. R. Mackley; The effect of droplet extension on the rheology of emulsions of water in alkyd resin. J. Rheol. 1 November 2001; 45 (6): 1341–1358. https://doi.org/10.1122/1.1410371 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
Synthesis and Catalytic Activity of Crown Jewel‐Structured (IrPd)/Au Trimetallic Nanoclusters (2014)

Crown-jewel-structured (IrPd)/Au trimetallic nanoclusters are prepared by a galvanic replacement reaction using Ir/Pd nanoclusters with a structure of Ir rich in the core and Pd rich in the shell as mother clusters. The catalytic activity of the top Au atoms for aerobic glucose oxidation of the trimetallic nanoclusters is the highest ever reported among all supported and colloidal catalysts.
200mW 192nm Generation using CsLiB6O10 Crystal (1998)

More than 200mW average power at 192nm was obtained at repetition frequency of 100Hz using CLBO as the final sum ferequency mixing crystal.
Innovative Two-Stage Multibeam Klystron: Concept and Modeling (2020)

Energy consumption is a major concern for future large-scale high-energy accelerator projects such as the compact linear collider (CLIC), future circular collider (FCC), and international linear collider (ILC). Thus, efficient generation of microwave power recently gained new attention by the accelerator community. In response, we propose an innovative two-stage multibeam klystron (TS-MBK) concept. It combines a very high RF power generation efficiency (84%) with a compact and cost effective electro-mechanical configuration. This article presents the concept and design study of a 1.0-GHz, 24-MW klystron. The technological novelties and mitigation of issues specific to this concept are described. TS-MBK performance has been validated using particle-in-cell computer simulations.
Novel approaches to antimicrobial therapy: peptide deformylase. (2002)

Peptide deformylase (PDF) represents one of the most exciting new targets for the development of novel antimicrobial chemotherapies. PDF is an essential bacterial metalloenzyme that deformylates the N-formylmethionine of newly synthesized bacterial polypeptides. Recent progress in understanding the structure and function of PDF has greatly facilitated the drug discovery process. In this article, the potential of PDF as an antimicrobial target is reviewed, and progress in the development of PDF inhibitors (PDFIs) is highlighted. Several structural classes of compounds have been reported as inhibitors of PDF. However, the real challenge has been in obtaining molecules with potent in vivo antibacterial activity against a range of drug-resistant pathogens. One of the more encouraging compounds reported, BB-83698 (British Biotech plc/Genesoft Inc), has shown in vivo efficacy against Streptococcus pneumoniae in both mouse thigh and lung infection models at doses equivalent to existing therapies. The published data suggest that PDFIs are a promising new class of antimicrobial agent best suited to treat respiratory tract infections (RTIs), but with the potential for activity against a variety of other pathogens. It is anticipated that the first PDFI targeting RTIs will enter the clinic soon.
Supplementary Table 18 from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia (2023)

&lt;p&gt;Single Cell ATAC Cell Type Populations&lt;/p&gt;
An Extensive Family of Heterometallic Titanium(IV)–Metal(III) Rings with Structure Control through Templates (2017)

Abstract A family of heterometallic [Cat][Ti x MO (x+1 )(O 2 C t Bu) 2x+2 ] rings is reported where Cat=a secondary or tertiary alkyl ammonium ion, x=7, 8 or 9, and M=Fe III , Ga III , Cr III , In III and Al III . The structures are regular polygons with eight, nine or ten vertices with each edge bridged by an oxide and two pivalates. The size of the ring formed is controlled by the alkylammonium cation present. In each case a homometallic by‐product is found [Cat][Ti x O (x+1 )(O 2 C t Bu) 2x−1 ].
Neuronotrophic Factors in Cellular Functional and Cognitive Repair of Adult Brain (1989)

Neuronotrophic factors (NTFs) are special proteins that control survival, growth and functional competence of selected neuronal populations during their development. A recently articulated CNS neuronotrophic hypothesis proposes that adult central neurons continue to be dependent on endogenous supplies of their NTFs for maintenance, function and repair capabilities. The hypothesis has important implications in two major neurologic areas:i) involutive and degenerative processes and ii) CNS regeneration. Strong evidence favoring this general hypothesis has come from the recently observed effects of Nerve Growth Factor (NGF) on the forebrain cholinergic neurons in adult rats. Medial septum cholinergic (MSC) neuros project to the hippocampal formation largely via the fimbria-fornix tract. Transection of the fimbria-fornix interrupts the retrograde delivery of hippocampal NGF to the MSC neuronal somata, leading to reduction in their cholinergic enzyme and, possibly, progressive cellular atrophy. Intraventricular administration of exogenous NGF compensates for the loss of endogenous NGF supply and can reverse as well as protect against the neuronal damage. In a second model, intraventricular NGF infusions were applied to 2-year old (aged) rats displaying a deficient cognitive behavior. Four-weeks administration resulted in i) a correction of the cognitive deficit and ii) a increased body size of basal forebrain cholinergic neurons Cholinergic deficits are known to accompany cognitive deficits both in the brain aging process and Alzheimer's disease. The NGF effects on aged rats, therefore, strongly encourage the possibility of future clinical application in both such cases of brain dysfunction.
Atomic layer deposition of a ruthenium thin film using a precursor with enhanced reactivity (2021)

The incubation cycle free ALD Ru film was deposited using an open-coordinated structured Ru(<sc>ii</sc>) precursor, Ru(η<sup>5</sup>-cycloheptadienyl)<sub>2</sub>.
Practical Immutable Signature Bouquets (PISB) for Authentication and Integrity in Outsourced Databases (2013)

Database outsourcing is a prominent trend that enables organizations to offload their data management overhead (e.g., query handling) to the external service providers. Immutable signatures are ideal tools to provide authentication and integrity for such applications with an important property called immutability. Signature immutability ensures that, no attacker can derive a valid signature for unposed queries from previous queries and their corresponding signatures. This prevents an attacker from creating his own de-facto services via such derived signatures. Unfortunately, existing immutable signatures are very computation and communication costly (e.g., highly interactive), which make them impractical for task-intensive and heterogeneous applications.In this paper, we developed two new schemes that we call Practical and Immutable Signature Bouquets (PISB ), which achieve efficient immutability for outsourced database systems. Both PISB schemes are very simple, non-interactive, and computation/communication efficient. Our generic scheme can be constructed from any aggregate signature coupled with a standard signature. Hence, it can flexibly provide performance trade-offs for various types of applications. Our specific scheme is constructed from Condensed-RSA and Sequential Aggregate RSA. It has a very low verifier computational overhead and end-to-end delay with a small signature size. We showed that PISB schemes are secure and also much more efficient than previous alternatives.
CDK1-mediated phosphorylation of the RIIα regulatory subunit of PKA works as a molecular switch that promotes dissociation of RIIα from centrosomes at mitosis (2001)

Protein kinase A regulatory subunit RIIalpha is tightly bound to centrosomal structures during interphase through interaction with the A-kinase anchoring protein AKAP450, but dissociates and redistributes from centrosomes at mitosis. The cyclin B-p34(cdc2) kinase (CDK1) has been shown to phosphorylate RIIalpha on T54 and this has been proposed to alter the subcellular localization of RIIalpha. We have made stable transfectants from an RIIalpha-deficient leukemia cell line (Reh) that expresses either wild-type or mutant RIIalpha (RIIalpha(T54E)). When expressed, RIIalpha detaches from centrosomes at mitosis and dissociates from its centrosomal location in purified nucleus-centrosome complexes by incubation with CDK1 in vitro. By contrast, centrosomal RIIalpha(T54E) is not redistributed at mitosis, remains mostly associated with centrosomes during all phases of the cell cycle and cannot be solubilized by CDK1 in vitro. Furthermore, RIIalpha is solubilized from particular cell fractions and changes affinity for AKAP450 in the presence of CDK1. D and V mutations of T54 also reduce affinity for the N-terminal RII-binding domain of AKAP450, whereas small neutral residues do not change affinity detected by surface plasmon resonance. In addition, only RIIalpha(T54E) interacts with AKAP450 in a RIPA-soluble extract from mitotic cells. Finally, microtubule repolymerization from mitotic centrosomes of the RIIalpha(T54E) transfectant is poorer and occurs at a lower frequency than that of RIIalpha transfectants. Our results suggest that T54 phosphorylation of RIIalpha by CDK1 might serve to regulate the centrosomal association of PKA during the cell cycle.
Mercury and selenium in workers previously exposed to mercury vapour at a chloralkali plant. (1993)

The concentrations of total mercury (B-Hg), inorganic mercury (B-IHg), and methyl mercury (B-MeHg) in whole blood, urinary mercury (U-Hg), and selenium in urine (U-Se) and whole blood (B-Se) were determined in 74 chloralkali workers previously exposed to Hg vapour, and compared with 51 age matched referents. Dental amalgam state, fish consumption, and exposure related indices were studied with regard to the determined elements. A significant relation between the surface of dental amalgam and U-Hg (Pearson's r = 0.63, p < 0.001) was found among the referents. Mean U-Se was significantly lower (p < 0.001) among the subjects previously exposed to Hg (34.1 nmol/mmol creatinine) compared with that for the referents (42.6 nmol/mmol creatinine). A significant negative relation between the cumulative Hg dose and U-Se was also found. The mechanisms and the clinical significance of these findings are not clear. No relation between current U-Hg and previous occupational exposure to Hg was found among subjects in whom exposure had ceased more than one year before the study.
Anti-Inflammatory Effects of Metabolites from Antarctic Fungal Strain Pleosporales sp. SF-7343 in HaCaT Human Keratinocytes (2021)

Chemical investigation of the Antarctic fungi <i>Pleosporales</i> sp. SF-7343 revealed four known secondary fungal metabolites: alternate C (<b>1</b>), altenusin (<b>2</b>), alternariol (<b>3</b>), and altenuene (<b>4</b>). The compound structures were identified primarily by NMR and MS analyses. Atopic dermatitis, an inflammatory disease, is driven by the abnormal activation of T helper (Th) 2 cells and barrier dysfunction. We attempted to identify the anti-inflammatory components of SF-7343. Initial screening showed that compounds <b>1</b> and <b>3</b> inhibited the secretion of interleukin-8 and -6 in tumor necrosis factor-α/interferon-γ-treated HaCaT cells, and these compounds also showed inhibitory effects on CCL5 and CCL22. Compounds <b>1</b> and <b>3</b> also downregulated the protein expression levels of intercellular adhesion molecule-1 and upregulated the expression of filaggrin and involcurin. The mechanism study results showed that compounds <b>1</b> and <b>3</b> inhibited nuclear translocation of nuclear factor-kappa B p65 and the phosphorylation of STAT1 and STAT3. Compound <b>1</b>, but not compound <b>3</b>, significantly promoted the expression of heme oxygenase (HO)-1. The effects of compound <b>1</b> were partly reversed by co-treatment with a HO-1 inhibitor, tin protoporphyrin IX. Taken together, this study demonstrates the potential value of Antarctic fungal strain SF-7343 isolates as a bioresource for bioactive compounds to prevent skin inflammation.
Fabrication of functional anisotropic food-grade micro-rods with micro-particle inclusions with potential application for enhanced stability of food foams (2009)

We have fabricated novel, food-grade anisotropic ‘lumpy’ micro-rods with micro-particle inclusions using an in-shear flow solvent attrition technique. Various micro-particle inclusions have been used in shellac and ethyl cellulose micro-rods which include sporopollenin microcapsules, porous silicas, yeast cells, sodium bicarbonate micro-crystals, metal micro-particles and magnetite nano-particles. Functionalisation of the micro-rods also involved thermal or microwave induced degradation of particles incorporated in the polymeric micro-rods. Using this technique we have produced a range of lumpy and ‘ballooned’ micro-rods and have characterised their morphologies by using optical and fluorescence microscopy. Our study indicates that the lumpy micro-rods have an increased efficiency as foam stabilisers compared with regular ‘smooth’ micro-rods without particle inclusions.
Internal plate fixation of fractures: short history and recent developments (2006)

Metal plates for internal fixation of fractures have been used for more than 100 years. Although initial shortcomings such as corrosion and insufficient strength have been overcome, more recent designs have not solved all problems. Further research is needed to develop a plate that accelerates fracture healing while not interfering with bone physiology. The introduction of rigid plates had by far the greatest impact on plate fixation of fractures. However, it led to cortical porosis, delayed bridging, and refractures after plate removal. These unwarranted effects were said to be caused by bone-plate contact interfering with cortical perfusion. Consequently, further plate modifications aimed to reduce this contact area to minimize necrosis and subsequent porosis. The advocates of limited-contact plates have not published measurements of the contact area or proof of the temporary nature of the porosis. Moreover, clinical studies of newer plate types have failed to show a superior outcome. Histomor-phometric measurements of the cortex showed no difference in the extent of necrosis under plates having different contact areas. Necrosis was predominant in the periosteal cortical half, whereas porosis occurred mostly in the endosteal cortical half. No positive correlation was found between either. The scientific evidence to date strongly suggests that bone loss is caused by stress shielding and not interference with cortical perfusion secondary to bone-plate contact. Consequently, an axially compressible plate (ACP) incorporating polylactide (PLA) inserts press-fit around screw holes was designed. The bioresorbable inserts should allow for (1) increased micromotion in the axial plane to promote healing during the union phase and (2) gradual degradation over time to decrease stress shielding during the remodeling phase. Results of ongoing experimental results are encouraging. Only plates allowing dynamic compression in the axial plane can lead to a revolution in fracture fixation.