gebhart/patrepeval huggingface dataset:
Effect of Disease Stage and Time Since Diagnosis on Time to Progression for Pegylated Liposomal Doxorubicin + Bortezomib vs Bortezomib Alone in Relapsed or Refractory Multiple Myeloma. (2007)

Abstract A recent report of a phase III randomized trial with pegylated liposomal doxorubicin (PLD)+bortezomib vs. bortezomib alone in relapsed or refractory multiple myeloma (RRMM) demonstrated improved time to progression (TTP) with PLD+bortezomib (Orlowski, JCO 2007). The present post-hoc analyses evaluated the efficacy of PLD+bortezomib according to International Staging System (ISS) disease stage, and time since initial myeloma diagnosis (TSD). Patients with ≥1 prior therapy were randomized to receive PLD at 30 mg/m2 on day 4 and bortezomib at 1.3 mg/m2 on days 1, 4, 8, and 11, or bortezomib alone for up to eight 21-day cycles, or at least 2 cycles beyond CR, or optimal response unless disease progression or unacceptable toxicities occurred. The improved TTP reported previously with PLD+bortezomib over bortezomib alone in the total study population was also observed in the higher risk groups based on disease stage (ISS 2 &amp; 3; Table). TTP was also significantly longer with PLD+bortezomib vs. bortezomib for TSD &gt;2 yrs despite more protracted disease. The therapeutic advantage of prolonged TTP with the PLD+bortezomib combination was maintained consistently across subgroups (heterogeneity tests: ISS 1 vs. 2 vs. 3, p=0.407; TSD ≤2 yrs. vs. &gt;2 yrs., p=0.946). Incidence of grade 3/4 neuropathies was low (&lt;10%) in the two treatment arms in all subgroups. PLD-related hand-foot syndrome was also &lt;10% in all PLD+bortezomib subgroups. Despite high-grade disease or protracted disease history, the PLD+bortezomib combination shows significantly improved TTP as compared to bortezomib alone. Also, the combination therapy was well-tolerated.
Supplementary Table 2 from A Panel of Four miRNAs Accurately Differentiates Malignant from Benign Indeterminate Thyroid Lesions on Fine Needle Aspiration (2023)

&lt;p&gt;PDF file - 78K&lt;/p&gt;
Stable noise-like pulse generation in all-PM mode-locked Tm-doped fiber laser based on NOLM (2021)

A stable noise-like (NL) mode-locked Tm-doped fiber laser (TDFL) relying on a nonlinear optical loop mirror (NOLM) was experimentally presented. Different from the previous NL mode-locked TDFL with NOLM, the entire polarization-maintaining (PM) fiber construction was utilized in our laser cavity, which makes the oscillator have a better resistance to environmental perturbations. The robust TDFL can deliver stable bound-state NL pulses with a pulse envelope tunable from ~14.1 ns to ~23.6 ns and maximum pulse energy of ~40.3 nJ at a repetition rate of ~980.6 kHz. Meanwhile, the all-PM fiber laser shows good power stability (less than ~0.7%) and repeatability.
Risk of ventricular tachycardia and its outcomes in patients undergoing continuous renal replacement therapy due to acute kidney injury (2023)

Sustained VT occurrence after starting CRRT is associated with increased patient mortality. The monitoring of electrolytes and acid-base status during CRRT is essential because of its relationship with the risk of VT.
Diagnosing HIV Infection During Healthcare Visits: Can We Do Better? (2013)

Almost 20% of HIV-infected individuals in the U.S. are unaware of their HIV status and thus could inadvertently transmit the virus to others. With the
Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases (2001)

This review summarizes the recent developments on the regulation of human pyruvate dehydrogenase complex (PDC) by site-specific phosphorylation by four kinases. Mutagenic analysis of the three phosphorylation sites of human pyruvate dehydrogenase (E1) showed the site-independent mechanism of phosphorylation as well as site-independent dephosphorylation of the three phosphorylation sites and the importance of each phosphorylation site for the inactivation of E1. Both the negative charge and size of the group introduced at site 1 were involved in human E1 inactivation. Mechanism of inactivation of E1 was suggested to be site-specific. Phosphorylation of site 1 affected E1 interaction with the lipoyl domain of dihydrolipoamide acetyltransferase, whereas phosphorylation site 3 appeared to be closer to the thiamine pyrophosphate (TPP)-binding region affecting coenzyme interaction with human E1. Four isoenzymes of pyruvate dehydrogenase kinase (PDK) showed different specificity for the three phosphorylation sites of E1. All four PDKs phosphorylated sites 1 and 2 in PDC with different rates, and only PDK1 phosphorylated site 3. PDK2 was maximally stimulated by the reduction/acetylation of the lipoyl groups of E2. Presence of the multiple phosphorylation sites and isoenzymes of PDK is important for the tissue-specific regulation of PDC under different physiological conditions.
Host immune suppression after small bowel/liver transplantation in rats (1994)

Simultaneous liver grafting in the Lewis (RT1)-to-DA (RT1) rat strain combination protects small intestinal grafts from rejection. The present study examined host immune responses after combined small bowel/liver transplantation (SBL) in this model. Orthotopic liver transplantation and heterotopic small intestinal transplantation were performed simultaneously and compared with isolated small bowel allografts (SBA) and isolated small bowel isografts (SBI). All rats were sacrificed on postoperative day (POD) 7 or 14 for immunological and histological studies. The mean time to rejection of the SBA was 6.6 +/- 0.3 days. In contrast, there was no clinical or histological evidence of intestinal rejection in SBL recipients during the 14 days of follow-up. The SBL recipients showed clinical and histological evidence of graft-versus-host disease (GVHD). Lymphocyte proliferation and IL-2 production in response to donor antigens were suppressed after SBL transplantation compared with the SBA or the SBI controls (P < 0.05). Cell-mediated cytotoxicity and lymphocytotoxic antibody production against donor cells were also significantly inhibited in the SBL recipients compared with the SBA control group (P < 0.05). We conclude that SBL transplantation in the Lewis-to DA rat strain combination: (1) suppresses host alloimmune responses, (2) prevents early intestinal rejection, and (3) favors the development of GVHD.
Corrigendum: Anti-HIV-1 nanobody-IgG1 constructs with improved neutralization potency and the ability to mediate Fc effector functions (2022)

[This corrects the article DOI: 10.3389/fimmu.2022.893648.].
Modelling of nonlinear magnetic damping in vibrating coupled structures (2019)

Vibrations of a three degrees of freedom mechanical structure are attenuated using a magnetic damper, obtained by coupling a conductive structure with a magnetic field generated by permanent magnets. The magnetic dissipations are experimentally investigated focusing on their nonlinearity with respect to frequency and amplitude of oscillations. The system exhibits two types of nonlinearities: one proper of the mechanical system and one of due to the magnetic coupling. The availability of an electromagnetic-motional model allows for the separation of these two effects. A frequency domain model to describe the magneto-mechanical interaction under harmonic excitation is developed by means of a partial element equivalent circuit of the conductive parts. The restitution magnetic force model is then introduced in the numerical model of the system. Results obtained by simulations are validated versus experimental measurements on the three degrees of freedom structure.
An adaptive, balanced and energy efficient clustering mechanism for UAV networks (2021)

Unmanned aerial vehicles (UAVs) are widely used in many fields, both civilian and military. Mostly mini UAVs are used in civilian applications which are preferred both in terms of affordability and availability. However, these vehicles are insufficient for some applications when they are used alone. This inadequacy is often observed in mini-UAVs having limited capacity in terms of energy storage and payloads. As a solution to this challenge, swarms of networked mini UAVs have been proposed. Thus, the UAVs in such networks are assigned with different tasks to accomplish the overall mission. While such UAV networks have many advantages, they also come with challenges. These challenges include limited on-board energy storage, low power and lossy wireless communication interface, and limited useful payload carrying capability. In this study, a new adaptive, balanced and energy efficient clustering mechanism has been proposed for such UAV networks.
Quality of life in the CRITICS study, a multicenter randomized phase III trial of neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy in resectable gastric cancer. (2018)

4060 Background: Patient-reported outcome is an important objective in clinical trials, as it addresses the impact of the disease and treatment on health-related quality of life (HRQOL). In the multicenter randomized phase III CRITICS study no significant difference in overall survival was found between postoperative chemotherapy and chemoradiotherapy after neo-adjuvant chemotherapy and D2 surgery (5-year OS 42% vs 40%). The CRITICS study investigated health-related quality of life in both treatment groups as one of the secondary objectives. Methods: Patient-reported outcome questionnaires were completed at baseline, after preoperative chemotherapy, after surgery, after postoperative chemotherapy (CT) or chemoradiotherapy (CRT) and during follow-up at 12 months after the end of postoperative treatment for 788 patients with adenocarcinoma of the stomach. Cancer-related quality of life was assessed by the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). A QLQ-C30 summary score at each time point was calculated as the mean of the combined 13 QLQ-C30 scale scores (max score 100; financial impact and global quality of life scale scores excluded). Linear mixed-modeling was applied to assess differences in the QLQ-C30 summary score between the CT and CRT group, accounting for missing values during follow-up. Results: 645 patients out of the 788 patients had at least one evaluable questionnaire. The number of evaluable questionnaires was comparable between the CT and CRT groups. Evolution of QLQ-C30 summary scores over time was non-linear with baseline scores of 86 vs 84, lowest scores after surgery of 77 vs 75 and recovery of the scores to 83 vs 80 after 12 months of follow-up. No significant differences in QLQ-C30 summary scores over time were observed between the CT and CRT group (p = 0.567). Conclusions: In the CRITICS study HRQOL summary scores showed no differences over time between the CT and the CRT group. Besides HRQOL, pathological T- and N-stage, resection margin status and histological type contribute to the optimal choice of treatment. Clinical trial information: NCT00407186.
Multimodal Magnetic Resonance Imaging for Assessing Evolution of Ischemic Penumbra: A Key Translational Medicine Strategy to Manage the Risk of Developing Novel Therapies for Acute Ischemic Stroke (2008)

The implicit aim of neuroprotection is to rescue neurons within distressed but still viable tissue, thereby promoting functional recovery upon neuronal salvage. The clinical failure of this approach suggests that previous efforts to develop stroke therapies lacked means to predict success or futility in pre-clinical and early clinical studies. A key translational medicine strategy that can improve predictability relies on imaging methodologies to map the spatiotemporal evolution of the ischemic penumbra. This could serve as a biomarker indicative of neuroprotective potential and could increase likelihood of success in clinical studies by allowing selection of patients who are most likely to respond to therapy.
WSN01-5: Efficient Data Collection through Compression-Centric Routing (2006)

Efficient sensor data fusion is one of the more critical and challenging tasks in building practical sensor networks. It is widely understood that transmitting raw sensor data to a central location for processing is severely hampered by scaling in large scale wireless networks, both in terms of energy consumption and latency costs. However, many detection, classification, estimation, and phenomena modeling algorithms rely heavily on the individual data from each sensor and thus, require raw data collection if not from the entire network, then at least among localized node clusters of varying sizes, hi order to make the data collection as efficient as possible, various proposed sampling and compression techniques have been, and are being investigated. As we demonstrate, in addition to the compression algorithm, the topology of the aggregation (e.g. the routes used) can play a significant role in the achievable compression rates, hi this paper, we propose a compression-centric data collection algorithm for use in wireless sensor networks. The algorithm relies on the construction of a Minimum Cost Tree (MCT), using neighbor data correlation as the optimization heuristic along the tree. By selecting routes that traverse nodes with higher degrees of data correlation, it is possible to achieve superior compression results when compared to more naive minimum spanning tree algorithm variations, hi addition to presenting the details of our distributed MCT algorithm, we use simulated data as well as actual data from a real sensor network to validate and demonstrate the performance of the new compression-centric routing scheme.
Keck Interferometer Nuller Data Reduction and On-Sky Performance (2009)

ABSTRACT. We describe the Keck Interferometer nuller theory of operation, data reduction, and on-sky per-formance, particularly as it applies to the nuller exozodiacal dust key science program that was carried out between 2008 February and 2009 January. We review the nuller implementation, including the detailed phasor processing involved in implementing the null-peak mode used for science data and the sequencing used for science observing. We then describe the Level 1 reduction to convert the instrument telemetry streams to raw null leakages, and the Level 2 reduction to provide calibrated null leakages. The Level 1 reduction uses conservative, primarily linear processing, implemented consistently for science and calibrator stars. The Level 2 processing is more flexible, and uses diameters for the calibrator stars measured contemporaneously with the interferometer’s K-band cophasing system in order to provide the requisite accuracy. Using the key science data set of 462 total scans, we assess the instrument performance for sensitivity and systematic error. At 2.0 Jy we achieve a photometrically-limited null leakage uncertainty of 0.25 % rms per 10 minutes of integration time in our broadband channel. From analysis of the Level 2 reductions, we estimate a systematic noise floor for bright stars of ∼0:2 % rms null leakage uncertainty per observing cluster in the broadband channel. A similar analysis is performed for the narrowband channels. We also provide additional information needed for science reduction, including details on the instrument beam pattern and
Forensic studies of infrasound from massive hypersonic sources (2004)

The rumble of hypersonic objects tearing through the atmosphere can be routinely detected by sensitive infrasound sensors [ Brown et al ., 2002]. Meteors and reentering spacecraft are the most common hypersonic sources, although supersonic aircraft generate comparable signatures. This article concentrates on two exceptionally energetic events: the tragic Columbia reentry of 1 February 2003 (STS‐107) and the 23 April 2001 superbolide explosion. On 23 April 2001, a large meteor exploded at a height of ˜28.5 km between Hawaii and California. With an estimated explosive energy of ˜10 k of TNT, this event catalyzed the U.S. infrasound community to work with other sectors of government, academia, and industry to provide rapid analyses of any available infrasound, seismic, hydroacoustic, and satellite data that would help identify the explosion source and determine its location.
Detection of Salmonella Enteritidis in Pooled Poultry Environmental Samples Using a Serotype-Specific Real-Time–Polymerase Chain Reaction Assay (2013)

While real-time-polymerase chain reaction (RT PCR) has been used as a rapid test for detection of Salmonella Enteritidis in recent years, little research has been done to assess the feasibility of pooling poultry environmental samples with a Salmonella Enteritidis-specific RT PCR assay. Therefore the objective of this study was to compare RT PCR Salmonella Enteritidis detection in individual and pooled (in groups of two, three, and four) poultry environmental drag swab samples to traditional cultural methods. The drag swabs were collected from poultry facilities previously confirmed positive for Salmonella Enteritidis and were cultured according to National Poultry Improvement Plan guidelines. Initial, Salmonella Enteritidis-specific RT PCR assay threshold cycle cutoff values of < or = 36, < or = 30, and < or = 28 were evaluated in comparison to culture. The average limit of detection of the RT PCR assay was 2.4 x 10(3) colony-forming units (CFUs)/ml, which corresponded to an average threshold cycle value of 36.6. Before enrichment, samples inoculated with concentrations from 10(2) to 10(5) CFUs/ml were detected by RT PCR, while after enrichment, samples inoculated from 10(0) to 10(5) CFUs/ml were detected by RT PCR. Threshold cycle cutoff values were used in the subsequent field trial from which Salmonella Enteritidis was cultured in 7 of 208 environmental samples (3.4%). Individual samples were 99.0%, 100%, and 100% in agreement with the RT PCR at threshold cycle (C(t)) cutoff values of < or = 36, < or = 30, and < or = 28 respectively. The agreement for pooled samples also followed the same trend with highest agreement at C(t) < or = 28 (pool of 2 = 100.0%, pool of 3 = 100.0%, pool of 4 = 100.0%), midrange agreement at C(t) < or = 30 (pool of 2 = 99.0%, pool of 3 = 100.0%, pool of 4 = 100.0%), and lowest agreement at C(t) < or = 36 (pool of 2 = 98.1%, pool of 3 = 97.1%, pool of 4 = 98.1%). In conclusion, regardless of the level of pooling after tetrathionate enrichment, sensitivity was very good, and results would be comparable to what would have been found with individual culture or individual RT PCR at C(t) < or = 36.
Two‐Level Pole Design (2009)

This chapter contains sections titled: A Three-Phase, Six-Pulse VSC with Two-Level Poles Analysis of a Pole
Non‐invasive investigations of early embryonic cardiac blood flow with optical coherence tomography (2006)

Objective The purpose of this investigation was to develop techniques to non‐invasively measure blood flow velocities in the tubular embryonic chick heart with optical coherence tomography (OCT) technologies. The early chick and mammalian embryonic heart is extremely small (&lt; 2mm) and, once the heart begins to beat, continually moves. A system with high spatial and temporal resolution is necessary to accurately image such small organs. We have devised methods for using OCT, an imaging device capable of high spatial (2–15 microns) and temporal (10–100 frames per second) resolution, for investigations of early embryonic structure and function. We present investigations of structure and blood flow in embryonic chick hearts from stage 8 (prior to the embryonic heart beat) through stage 13, after onset of the heartbeat and after cardiac looping has begun. Color Doppler investigations revealed that flow through the atrioventricular canal, the precursor of the atrioventricular valves, was laminar, while flow through the outflow tract, precursor of the aortic and pulmonary valves, appeared more complex. These findings suggest that blood flow and blood flow velocity may play a role in the divergent developmental pathways taken by the atrioventricular vs. the outflow tract endocardial cushions. Support: AHA 0365348B (FR).
Future Directions in the Oncological Treatment of Colorectal Cancer (2006)

This chapter contains section titled: The future of adjuvant chemotherapy The future of locally advanced rectal cancer therapy The future approach to the treatment of metastatic colorectal cancer Conclusions
EpiMethylTag: simultaneous detection of ATAC-seq or ChIP-seq signals with DNA methylation (2019)

Activation of regulatory elements is thought to be inversely correlated with DNA methylation levels. However, it is difficult to determine whether DNA methylation is compatible with chromatin accessibility or transcription factor (TF) binding if assays are performed separately. We developed a fast, low-input, low sequencing depth method, EpiMethylTag, that combines ATAC-seq or ChIP-seq (M-ATAC or M-ChIP) with bisulfite conversion, to simultaneously examine accessibility/TF binding and methylation on the same DNA. Here we demonstrate that EpiMethylTag can be used to study the functional interplay between chromatin accessibility and TF binding (CTCF and KLF4) at methylated sites.
Towards Low Latency Industrial Robot Control in Programmable Data Planes (2020)

Due to the advanced control and machine learning techniques, today's industrial robots are faster and more accurate than human workers in well-structured repetitive tasks. However, in case of sudden changes in the operational area, such as unexpected obstacles or humans, robots have to be continuously monitored by powerful controllers for swift interventions (i.e., send emergency stop signals). As in the case of many verticals (e.g., transportation, shopping), the proliferation of Software-Defined Networking (SDN) and Network Function Virtualization (NFV) has started to captivate industry 4.0 as well in order to benefit from low infrastructure costs, and flexible management and resource provisioning. Besides all the advantages of the centralized approach, however, in critical situations (e.g., possible collisions, actuator damages or human injuries) the required ultra-low latency between the robots and the controller becomes an all-important factor, and one of the main concerns, at the same time, for industry leaders making the decision towards this paradigm shift. In this paper, we argue that by relying on recently emerged stateful and programmable data planes, it is possible to fill this gap by offloading latency-critical applications to the network, thereby bringing some intelligence much closer the robots. We present the first in-network robotic control application that is capable to intercept the communication between the robot and the controller and craft responses immediately if needed. In particular, we show that we can detect position threshold violations entirely in the data plane, close to the robot, and deliver emergency stop commands within no time with full compliance to the actual TCP session and application states.
Traitement d'antenne haute résolution pour des signaux non circulaires (1997)

We present in this article an angular location algorithm of non circular sources. We show how to take into account non circularity of signals in array processing and develop an extension of the MUSIC, Root-MUSIC and Capon algorithms. These extensions offer, for an implementation relatively simple, performance appreciably superior the classic algorithms . The main improvement linked to the non circularity concern the resolution, the variance of estimation and the number of localizable sources. These characteristics are illustrated by simulations.