gebhart/patrepeval huggingface dataset:
Evaluation of a satisfied bilateral scleral expansion band patient (2004)

No increase in accommodative amplitude above normal age-matched controls was found. Patient satisfaction may have come from the high expectations this patient had for a positive surgery outcome.
The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1,626 patients (2007)

Besides unprovoked presentation, other factors independently associated with a statistically significant increased risk of recurrent VTE are thrombophilia, clinical presentation with primary DVT, shorter duration of anticoagulation, and increasing age.
Antibodies against PM/Scl-75 and PM/Scl-100 are independent markers for different subsets of systemic sclerosis patients (2009)

Anti-PM/Scl antibodies are common in distinct SSc subsets and are associated with several clinical symptoms. They are directed mainly to the PM/Scl-75 antigen. Consequently, the detection of anti-PM/Scl antibodies by tests based only on PM/Scl-100 as an antigen source may miss a relevant number of SSc patients positive for these antibodies.
DEVELOPMENT OF A GENETIC ALGORITHM FOR NEUTRON ENERGY SPECTRUM ADJUSTMENT. (2015)

Abstract not provided.
Ultrasonic Chemistry: Carbon–Heteroatom Bond Formation by an Ultrasonic Chemical Reaction for Energy Storage Systems (Adv. Mater. 47/2017) (2017)

In article number 1702747, Jong-Beom Baek, Tae-Hyuk Kwon, and co-workers report direct C–N and C–O bond formation in various carbon nanomaterials with N2 or O2 gas by a simple ultrasonic spray chemical reaction. The resulting N-doped carbon nanomaterials display remarkable performance for energy-storage applications. Furthermore, the double-nozzle system used for the ultrasonic deposition can produce a layer-by-layer N-RGO/N-CNT multidimensional carbon framework, which further improves the energy-storage performance.
Enhanced Prevalence of Plasmatic Soluble MHC Class I Chain-Related Molecule in Vascular Pregnancy Diseases (2014)

The major histocompatibility complex class I related chain (MIC) is a stress-inducible protein modulating the function of immune natural killer (NK) cells, a major leukocyte subset involved in proper trophoblast invasion and spiral artery remodeling. Aim of the study was to evaluate whether upregulation of soluble MIC (sMIC) may reflect immune disorders associated to vascular pregnancy diseases (VPD). sMIC was more frequently detected in the plasma of women with a diagnostic of VPD (32%) than in normal term-matched pregnancies (1.6%, P < 0.0001), with highest prevalence in intrauterine fetal death (IUDF, 44%) and vascular intrauterine growth restriction (IUGR, 39%). sMIC levels were higher in preeclampsia (PE) than in IUFD (P < 0.01) and vascular IUGR (P < 0.05). sMIC detection was associated with bilateral early diastolic uterine notches (P = 0.037), thrombocytopenia (P = 0.03), and high proteinuria (P = 0.03) in PE and with the vascular etiology of IUGR (P = 0.0038). Incubation of sMIC-positive PE plasma resulted in downregulation of NKG2D expression and NK cell-mediated IFN-γ production in vitro. Our work thus suggests that detection of sMIC molecule in maternal plasma may constitute a hallmark of altered maternal immune functions that contributes to vascular disorders that complicate pregnancy, notably by impairing NK-cell mediated production of IFN-γ, an essential cytokine favoring vascular modeling.
Histone H3 Lysine 9 Methyltransferase G9a Is a Transcriptional Coactivator for Nuclear Receptors (2006)

Methylation of Lys-9 of histone H3 has been associated with repression of transcription. G9a is a histone H3 Lys-9 methyltransferase localized in euchromatin and acts as a corepressor for specific transcription factors. Here we demonstrate that G9a also functions as a coactivator for nuclear receptors, cooperating synergistically with nuclear receptor coactivators glucocorticoid receptor interacting protein 1, coactivator-associated arginine methyltransferase 1 (CARM1), and p300 in transient transfection assays. This synergy depends strongly on the arginine-specific protein methyltransferase activity of CARM1 but does not absolutely require the enzymatic activity of G9a and is specific to CARM1 and G9a among various protein methyltransferases. Reduction of endogenous G9a diminished hormonal activation of an endogenous target gene by the androgen receptor, and G9a associated with regulatory regions of this same gene. G9a fused to Gal4 DNA binding domain can repress transcription in a lysine methyltransferase-dependent manner; however, the histone modifications associated with transcriptional activation can inhibit the methyltransferase activity of G9a. These findings suggest a link between histone arginine and lysine methylation and a mechanism for controlling whether G9a functions as a corepressor or coactivator.
Noise-aided gradient descent bit-flipping decoders approaching maximum likelihood decoding (2016)

In the recent literature, the study of iterative LDPC decoders implemented on faulty-hardware has led to the counter-intuitive conclusion that noisy decoders could perform better than their noiseless version. This peculiar behavior has been observed in the finite codeword length regime, where the noise perturbating the decoder dynamics help to escape the attraction of fixed points such as trapping sets. In this paper, we will study two recently introduced LDPC decoders derived from noisy versions of the gradient descent bit-flipping decoder (GDBF). Although the GDBF is known to be a simple decoder with limited error correction capability compared to more powerful softdecision decoders, it has been shown that the introduction of a random perturbation in the decoder could greatly improve the performance results, approaching and even surpassing belief propagation or min-sum based decoders. For both decoders, we evaluate the probability of escaping from a Trapping set, and relate this probability to the parameters of the injected noise distribution, using a Markovian model of the decoder transitions in the state space of errors localized on isolated trapping sets. In a second part of the paper, we present a modified scheduling of our algorithms for the binary symmetric channel, which allows to approach maximum likelihood decoding (MLD) at the cost of a very large number of iterations.
Reconfigurable ULAs for Line-of-Sight MIMO Transmission (2020)

This paper establishes an upper bound on the capacity of line-of-sight multiantenna channels over all possible antenna arrangements and shows that uniform linear arrays (ULAs) with an SNR-dependent rotation of transmitter or receiver can closely approach such capacity---and in fact achieve it at low and high SNR, and asymptotically in the numbers of antennas. Then, as an alternative to mechanically rotating ULAs, we propose to electronically select among multiple ULAs having a radial disposition at either transmitter or receiver, and we bound the shortfall from capacity as a function of the number of such ULAs. With only three ULAs, properly angled, 96% of the capacity can be achieved. Finally, we further introduce reduced-complexity precoders and linear receivers that capitalize on the structure of the channels spawned by these configurable ULA architectures.
Single-Photon and Photon-Number-Resolving Detectors (2012)

Several important advances were reported in single-photon detectors and photon-number-resolving detectors in 2011. New materials with smaller superconducting gaps were demonstrated for superconducting nanowire single-photon detectors (SNSPDs) that led to improved signal-to-noise ratios and infrared performance. Faster superconducting transition edge sensors (TESs) were demonstrated by using normal metal heat sinks. Both TESs and SNSPDs were evanescently coupled with waveguides as a step toward demonstrating quantum photonic integrated circuits. Photon-number resolution has been the goal in several demonstrations using semiconductor detectors, and recent results suggest a potential convergence of Geiger-mode and linear-mode avalanche diodes in exhibiting the high-gain, low-noise analog behavior necessary to reach this goal. There has also been progress focused on additional trends in single-photon avalanche diodes (SPADs) for high- rate counting and detector array scaling.
67.1: <i>Invited Paper</i> : Low Cost Lasers and Laser Arrays for Projection Displays (2006)

Abstract High power, frequency doubled surface emitting diode laser array technology has been demonstrated for use in low cost projection display systems.
Autonomous learning of abstractions using Curiosity-Driven Modular Incremental Slow Feature Analysis (2012)

To autonomously learn behaviors in complex environments, vision-based agents need to develop useful sensory abstractions from high-dimensional video. We propose a modular, curiosity-driven learning system that autonomously learns multiple abstract representations. The policy to build the library of abstractions is adapted through reinforcement learning, and the corresponding abstractions are learned through incremental slow-feature analysis (IncSFA). IncSFA learns each abstraction based on how the inputs change over time, directly from unprocessed visual data. Modularity is induced via a gating system, which also prevents abstraction duplication. The system is driven by a curiosity signal that is based on the learnability of the inputs by the current adaptive module. After the learning completes, the result is multiple slow-feature modules serving as distinct behavior-specific abstractions. Experiments with a simulated iCub humanoid robot show how the proposed method effectively learns a set of abstractions from raw un-preprocessed video, to our knowledge the first curious learning agent to demonstrate this ability.
Links as a Service (LaaS) (2016)

The most demanding tenants of shared clouds require complete isolation from their neighbors, in order to guarantee that their application performance is not affected by other tenants. Unfortunately, while shared clouds can offer an option whereby tenants obtain dedicated servers, they do not offer any network provisioning service, which would shield these tenants from network interference. In this paper, we introduce Links as a Service (LaaS), a new abstraction for cloud service that provides isolation of network links. Each tenant gets an exclusive set of links forming a virtual fat-tree, and is guaranteed to receive the exact same bandwidth and delay as if it were alone in the shared cloud. Consequently, each tenant can use the forwarding method that best ?ts its application. Under simple assumptions, we derive theoretical conditions for enabling LaaS without capacity over-provisioning in fat-trees. New tenants are only admitted in the network when they can be allocated hosts and links that maintain these conditions. LaaS is implementable with common network gear, tested to scale to large networks and provides full tenant isolation at the worst cost of a 10% reduction in the cloud utilization.
Highly Efficient Broadband Millimeter‐Wave–Absorbing Ultrathin Films (2021)

Millimeter waves (30–300 GHz) hold promise as carrier waves for car radars, next‐generation wireless communications, and beyond fifth‐generation technology standards for broadband cellular networks (Beyond 5G). Millimeter‐wave absorbers suppress noise and crosstalk between devices. Herein, a high‐efficiency broadband millimeter‐wave absorber based on a composite of aggregated tetratitanium heptoxide nanocrystals covered by Ga–Ti–Co–substituted ε‐iron oxide nanomagnets (Ti 4 O 7 @GTC‐ε‐Fe 2 O 3 ) is reported. This composite exhibits both high permeability (high‐ μ ) and high dielectric constant (high‐ ε ) in the millimeter‐wave range. In addition, millimeter‐wave–absorbing ultrathin films are designed and prepared. The 183‐μm absorber suppresses 99.1% (−20.3 dB) of the reflections at 78 GHz with a broadband absorption of 14.3 GHz. Because it is composed of only inorganic materials, this absorber is weather‐resistant and suitable for outdoor use. Furthermore, a 216‐μm flexible ultrathin film was prepared by mixing Ti 4 O 7 @GTC‐ε‐Fe 2 O 3 with an acrylic acid ester polymer. The flexible film is extremely lightweight, only 41 mg cm −2 , and strongly suppresses 99.8% (−27.2 dB) of the reflections at 80 GHz with an ultrawide absorption of 16.2 GHz. Such ultrathin and lightweight films exhibiting high efficiency for car radar frequencies are not reported so far and should be useful as absorbers for transportation vehicles.
1.55 μm electro-optical modulator using intersubband transitions in GaN/AlN superlattices (2007)

We report on a prototype 1.55 μm electro‐optical modulator based on intersubband transitions in a short‐period GaN/AlN superlattice. The device has a vertical architecture resembling a nitride‐based high‐electron mobility transistor, whose barrier layer has been replaced by a 5 period superlattice.
Ionic Strength and Curvature Effects in Flat and Highly Curved Polyelectrolyte Brushes (1998)

Adsorption of poly(tert-butylstyrene)/poly(styrenesulfonate) diblocks on polystyrene latices from water is reported and interpreted with scaling theories to demonstrate the effects of ionic strength and curvature on layer thickness. The adsorbed amount increases with ionic strength from no added salt to 0.1 M, forming a dense polyelectrolyte brush. The influence of particle radius on layer thickness is correlated quantitatively via the Daoud−Cotton model, but the effect on surface coverage is obscured by uncontrolled aspects of surface chemistry. Decreasing the ionic strength dramatically increases the dimensions of polyelectrolyte micelles and adsorbed layers; the sensitivity, while strongly coupled with curvature, is overestimated by all existing theories. A simple scaling theory that accounts for electrostatic excluded volume more appropriately captures the trends qualitatively.
Towards Bigger Nanogold: Preparation of Covalent 3nm Gold-Fab’ Probes (2005)

Extract HTML view is not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button. Extended abstract of a paper presented at Microscopy and Microanalysis 2005 in Honolulu, Hawaii, USA, July 31--August 4, 2005
Supplementary Movie S1 from MFF Regulation of Mitochondrial Cell Death Is a Therapeutic Target in Cancer (2023)

&lt;p&gt;Morphology of MFF targeting in tumor cells&lt;/p&gt;
AMG-232 sensitizes high MDM2-expressing tumor cells to T-cell-mediated killing (2020)

Oncogenic mouse double minute 2 homolog (MDM2) is an E3-ubiquitin ligase that facilitates proteasomal degradation of p53. MDM2 amplification occurs in cancer and has been implicated in accelerated tumor growth, known as hyper-progression, following immune-checkpoint therapy. MDM2 amplification also predicts poor response to immune-checkpoint inhibitors. We sought to evaluate the role of MDM2 in T-cell-mediated immune resistance. Ovarian clear cell carcinoma cell lines carrying wild-type p53 with low/high MDM2 expression were investigated in a T-cell co-culture system evaluating T-cell-mediated tumor killing. Targeting of MDM2 was achieved by siRNA transfection or a selective MDM2 inhibitor, AMG-232 and tumor cells were tested in the T-cell co-culture system. AMG-232 activated p53 signaling in cancer cells and relative resistance to AMG-232 was observed in high MDM2-expressing cell lines. Cell lines with high MDM2 expression were more resistant to T cell-mediated tumor killing. Targeting MDM2 by gene-silencing or pharmacological blockade with AMG-232 enhanced T-cell killing of cancer cells. AMG-232 potentiated tumor cell killing by T-cells in combination with anti-PD-1 antibody treatment, regardless of changes in PD-L1 expression. The AMG-232 was not toxic to the T-cells. MDM2 inhibition lowered expression of Interleukin-6, a pro-inflammatory pro-tumorigenic cytokine. Our data support targeting MDM2 in tumors with overexpression or amplification of MDM2 as a precision therapy approach to overcome drug resistance including hyper-progression in the context of immune checkpoint therapy.
Specific and Redundant Functions of Histone Deacetylases in Regulation of Cell Cycle and Apoptosis (2004)

Inappropriate control of expression of genetic information is the cause of many forms of cancer. Aberrant transcriptional repression by recruitment of histone deacetylases (HDACs) is a key step in pathogenesis of myeloid leukemia. We recently reported that development of colonic cancer involves alterations in the transcriptional repression machinery by increased expression of HDAC2 upon loss of the APC tumor suppressor. Increased expression of HDAC2 is essential for prevention of apoptosis of HT-29 colonic cancer cells. We now discuss whether HDAC2 also plays a role for aberrant cell cycle regulation and expression of the p21(Cip/Waf) cell cycle inhibitor. Whereas inhibition of HDACs by valproic acid or trichostatin A increases p21 expression, selective interference with HDAC2 by siRNA transfection or reconstitution of wildtype APC does not affect p21 expression. Likewise, treatment of HT-29 cells with the HDAC inhibitor valproic acid leads to a moderate inhibition of cell cycle progression in the G1 phase whereas interference with HDAC2 expression does not. Thus, HDAC2 appears to serve a preferential role in the prevention of apoptosis and not in cell cycle control similar to the specific importance of HDAC1 for cell cycle regulation or HDAC 9 for the stress response of the heart.
SLAM-Loop Closing with Visually Salient Features (2006)

Within the context of Simultaneous Localisation and Mapping (SLAM), “loop closing” is the task of deciding whether or not a vehicle has, after an excursion of arbitrary length, returned to a previously visited area. Reliable loop closing is both essential and hard. It is without doubt one of the greatest impediments to long term, robust SLAM. This paper illustrates how visual features, used in conjunction with scanning laser data, can be used to a great advantage. We use the notion of visual saliency to focus the selection of suitable (affine invariant) image-feature descriptors for storage in a database. When queried with a recently taken image the database returns the capture time of matching images. This time information is used to discover loop closing events. Crucially this is achieved independently of estimated map and vehicle location. We integrate the above technique into a SLAM algorithm using delayed vehicle states and scan matching to form interpose geometric constraints. We present initial results using this system to close loops (around 100m) in an indoor environment.
Zr(OBu<sup> <i>t</i> </sup>)<sub>4</sub>as a New Promoter for the Meerwein-Ponndorf-Verley Alkynylation and Cyanation of Aldehydes (2000)

Zr(OBu t )2 can serve as an effective promoter for the Meerwein-Ponndorf-Verley alkynylation of aldehydes and it was found to be particularly attractive in the Meerwein-Ponndorf-Verley cyanation.
Electroweak Effects in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msup><mml:mrow><mml:mi>e</mml:mi></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>e</mml:mi></mml:mrow><mml:mrow><mml:mo>−</mml:mo></mml:mrow></mml:msup></mml:mrow><mml:mo>→</mml:mo><mml:mrow><mml:msup><mml:mrow><mml:mi>μ</mml:mi></mml:mrow><mml:mrow><mml:mo>+</mml:mo></mml:mrow></mml:msup></mml:mrow><mml:mrow><mml:msup><mml:mrow><mml:mi>μ</mml:mi></mml:mrow><mml:mrow><mml:mo>−</mml:mo></mml:mrow></mml:msup></mml:mrow></mml:math>at 29 GeV (1983)

A measurement of the cross section for production of collinear muon pairs based upon a sample of about 3000 events observed in the MAC detector at the storage ring PEP is presented. From the angular asymmetry ${A}_{\ensuremath{\mu}\ensuremath{\mu}}=0.076\ifmmode\pm\else\textpm\fi{}0.018$ the axial-vector weak neutral coupling is found to be given by ${{g}_{A}}^{e}{{g}_{A}}^{\ensuremath{\mu}}=0.31\ifmmode\pm\else\textpm\fi{}0.08$.
Purine 8-bromination modulates the ribonuclease L binding and activation abilities of 2',5'-oligoadenylates. Possible influence of glycosyl torsion angle. (1987)

Analogs of the 2',5'-linked adenylate trimer diphosphate (pp5'A2'p5'A2'p5'A or 2-5A) containing 8-bromoadenosine in the first, second, third, first and third, or second and third nucleotide positions (from the 5' terminus) were synthesized and found to vary dramatically in their ability to bind to and activate the RNase L of mouse L cells. Whenever the 8-bromoadenosine residue was substituted for adenosine in the first or 5'-terminal residue, there resulted a marked decrease in ability to bind to the 2-5A-dependent endonuclease. A similar result was obtained when the second adenosine nucleotide was replaced by 8-bromoadenosine. To the contrary, all analogs that bore an 8-bromoadenosine (br8A) in the third or 2'-terminal position were bound about as well as parent 2-5A to RNase L. Additionally, the 5'-diphosphate pp5'A2'p5'A2'p5' (br8A) was 10 times more effective than 2-5A as an inhibitor of translation. An increase in stability could not explain this significantly enhanced ability since the 2'-terminally brominated analog showed a similar half-life to 2-5A itself. Finally of particular interest was the analog monophosphate p5'A2'p5'(br8A)2'p5'(br8A) which possessed nearly 10% of the translational inhibitory activity of 2-5A triphosphate itself. These results suggest that changes in the base-sugar torsion angles of 2-5A may modulate both binding to and activation of mouse L cell RNase L.
Average-Case Active Learning with Costs (2009)

We analyze the expected cost of a greedy active learning algorithm. Our analysis extends previous work to a more general setting in which different queries have different costs. Moreover, queries may have more than two possible responses and the distribution over hypotheses may be non uniform. Specific applications include active learning with label costs, active learning for multiclass and partial label queries, and batch mode active learning. We also discuss an approximate version of interest when there are very many queries.
Meso Scale Pulsating Jets for Electronics Cooling (2005)

Microfluid devices are conventionally used for boundary layer control in many aerospace applications. Synthetic jets are intense small-scale turbulent jets formed from periodic entrainment and expulsion of the fluid in which they are embedded. The jets can be made to impinge upon electronic components thereby providing forced convection impingement cooling. The small size of these devices accompanied by the high exit air velocity provides an exciting opportunity to significantly reduce the size of thermal management hardware in electronics. A proprietary meso scale synthetic jet designed at GE Global Research is able to provide a maximum air velocity of 90m∕s from a 0.85 mm hydraulic diameter rectangular orifice. An experimental study for determining the cooling performance of synthetic jets was carried out by using a single jet to cool a thin foil heater. The heat transfer augmentation caused by the jets depends on several parameters, such as, driving frequency, driving voltage, jet axial distance, heater size, and heat flux. During the experiments, the operating frequency for the jets was varied between 3.4 and 5.4 kHz, while the driving voltage was varied between 50 and 90VRMS. Two different heater powers, corresponding to approximately 50 and 80 °C, were tested. A square heater with a surface area of 156mm2 was used to mimic the hot component and detailed temperature measurements were obtained with a microscopic infrared thermal imaging technique. A maximum heat transfer enhancement of approximately 10 times over natural convection was measured. The maximum measured coefficient of performance was approximately 3.25 due to the low power consumption of the synthetic jets.