gebhart/patrepeval huggingface dataset:
Two-phase routing, scheduling and power control for wireless mesh networks with variable traffic (2007)

We consider the problem of joint routing, scheduling and transmission power assignment in multi-hop wireless mesh networks with unknown traffic. We assume the traffic is unknown, but the traffic matrix, which specifies the traffic load between every source-destination pair in the network, always lies inside a polytope defined by hose model constraints. The objective is to minimize the maximum of the total transmission power in the network over all traffic matrices in a given polytope. We propose efficient algorithms that compute a two-phase routing, schedule and power assignment, and prove the solution to be 3-approximation with respect to an optimal two-phase routing, scheduling and power assignment. We show via extensive simulations that the proposed algorithm has good performance at its worst operating traffic compared to an algorithm optimized for that traffic.
Supplementary Table 2 from A Phase I Study of the Safety, Pharmacokinetics, and Pharmacodynamics of Combination Therapy with Refametinib plus Sorafenib in Patients with Advanced Cancer (2023)

&lt;p&gt;Grade 3 or 4 adverse events possibly related to refametinib or sorafenib, occurring in {greater than or equal to}2 patients in either cohort&lt;/p&gt;
Mangelernährungsassessment bei gastroenterologischen Patienten: Zusammenhang zwischen Subjektive Global Assessment, bioelektrischer Impedanzanalyse und Surrogatparametern für eine praktikable Anwendung (2016)

Einleitung: Das Subjektive Global Assessment (SGA) ist eine validierte Methode zur Erfassung des Ernährungszustandes (EZ). Sowohl Körpergewicht als auch anthropometrische Parameter werden als valide Instrumente zur Identifizierung von Gewichtsverlust und quantitativen Körpersubstanzverlusten zur Diagnostik von Mangelernährung (ME) eingesetzt. Die bioelekrische Impedanzanalyse (BIA) liefert auch qualitativen Aussagen über den EZ des Patienten.
Anomalous difference signal in protein crystals (2003)

A scattering-angle-dependent formula is obtained for estimation of anomalous diffraction signals in Friedel pairs in protein crystals. In addition to the angle dependences of atomic form factor and temperature factor, a correlation form factor is introduced for the first time to take into account anomalous-scattering clusters such as disulfide bonds. Good agreements with experimental observations suggest that such correlated anomalous difference signals may be visible from measurements before a complete structural solution is obtained.
Quantum entanglement via nilpotent polynomials (2006)

We propose a general method for introducing extensive characteristics of quantum entanglement. The method relies on polynomials of nilpotent raising operators that create entangled states acting on a reference vacuum state. By introducing the notion of tanglemeter, the logarithm of the state vector represented in a special canonical form and expressed via polynomials of nilpotent variables, we show how this description provides a simple criterion for entanglement as well as a universal method for constructing the invariants characterizing entanglement. We compare the existing measures and classes of entanglement with those emerging from our approach. We derive the equation of motion for the tanglemeter and, in representative examples of up to four-qubit systems, show how the known classes appear in a natural way within our framework. We extend our approach to qutrits and higher-dimensional systems, and make contact with the recently introduced idea of generalized entanglement. Possible future developments and applications of the method are discussed.
Eight-Channel AC Magnetosusceptometer of Magnetic Nanoparticles for High-Throughput and Ultra-High-Sensitivity Immunoassay (2018)

An alternating-current magnetosusceptometer of antibody-functionalized magnetic nanoparticles (MNPs) was developed for immunomagnetic reduction (IMR). A high-sensitivity, high-critical-temperature superconducting quantum interference device was used in the magnetosusceptometer. Minute levels of biomarkers of early-stage neurodegeneration diseases were detectable in serum, but measuring each biomarker required approximately 4 h. Hence, an eight-channel platform was developed in this study to fit minimal screening requirements for Alzheimer's disease. Two consistent results were measured for three biomarkers, namely Aβ40, Aβ42, and tau protein, per human specimen. This paper presents the instrument configuration as well as critical characteristics, such as the low noise level variations among channels, a high signal-to-noise ratio, and the coefficient of variation for the biomarkers' IMR values. The instrument's ultrahigh sensitivity levels for the three biomarkers and the substantially shorter total measurement time in comparison with the previous single- and four-channels platforms were also demonstrated in this study. Thus, the eight-channel instrument may serve as a powerful tool for clinical high-throughput screening of Alzheimer's disease.
An optically pumped mid-infrared HBr laser (1994)

The results of experiments on a pulsed optically pumped vibrational transition HBr laser are discussed. In these experiments, rotation-vibration transitions in the first overtone band near 2 /spl mu/m are pumped with an optical parametric oscillator. Lasing is generated in (2,1) band transitions near 4 /spl mu/m. The laser performance is governed by gas phase kinetic processes, which redistribute the absorbed pump energy during the evolution of the laser pulse. A maximum 4-/spl mu/m output energy of 0.85 mJ was obtained with 3.47 mJ of absorbed pump energy.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Broadband Terahertz Plasmonic Response of Touching InSb Disks (2012)

The plasmonic behavior of dimers of touching semiconductor disks is studied experimentally in the difficult-to-realize regime where the disks are only marginally overlapping. Previous theoretical studies have shown that this geometry exhibits a highly efficient broadband response that may be very promising for light harvesting and sensing applications. By taking advantage of the plasmonic character of InSb in the terahertz regime, we experimentally confirm this broadband response and describe the associated strong field enhancement and sub-micrometer field confinement between the disks.
Automated testing of ARM Cortex based SoC with I3C interface and temperature sensor (2022)

The Improved Inter Integrated Circuit (I3C) interface is a scalable, medium-speed, utility and control bus interface designed for connecting peripherals to an application processor. It is a backward-compatible successor to the I2C interface with increased speed, additional functionalities and improved energy efficiency. The work presented in this paper supports the early adoption of the I3C interface at the industry level by establishing a validation methodology of the timing parameters of the I3C interface and by setting up appropriate digital design workflows used in implementing I3C interface in Systems-on-Chip (SoC). The timing validation methodology is based on a Hardware-inLoop (HIL) topology, while the design workflows are represented by two I3C-based SoC examples: the autonomous I3C target and the temperature sensor integrated in ARM Cortex-M0 periphery with I3C Target interface.
2A2-J10 Flying robot equipped with LRF with roundly swing device for indoor flight(Aerial Robot and Mechatronics(2)) (2012)

In case of disasters or accidents, such as earthquake, typhoon, and critical accidents, it may be occurred danger area that people can't enter. The areas may interfere with rescue work and wreak further damage. Flying robot which can move three-dimensionally and fly low altitude and narrow place is expected to play an important role in such disaster areas. The purpose of this study is to develop indoor autonomous flight control system using three-dimensional mapping by Laser Range Finder(LRF). If the LRF is fixed, in order to scan three-dimensionally, it is needed that flying robot to be able to move up and down. So in this study, we add roundly swing device that can scan three-dimensionally without moving up and down to flying robot.
Heparanase Plays a Dual Role in Driving Hepatocyte Growth Factor (HGF) Signaling by Enhancing HGF Expression and Activity (2010)

Hepatocyte growth factor (HGF) is a heparin-binding cytokine that enhances growth, motility, and angiogenesis of many tumor types, including multiple myeloma where it is often highly expressed. However, little is known regarding what controls HGF level and activity in these tumors. Evaluation of bone marrow biopsies from myeloma patients revealed a strong positive correlation between the levels of HGF and heparanase, an endoglucuronidase known to promote aggressive tumor behavior. In vitro, addition of recombinant heparanase to myeloma cells or transfection of myeloma cell lines with the cDNA for heparanase significantly increased tumor cell expression and secretion of biologically active HGF. Shed syndecan-1, whose levels in myeloma are also enhanced by heparanase expression, binds to secreted HGF. This syndecan-1-HGF complex is active as shown by its ability to stimulate paracrine signaling via c-Met, the cell surface receptor for HGF. Surprisingly, heparanase enzyme activity was not required for up-regulation of HGF expression by the tumor cells. This is in contrast to the heparanase-mediated enhanced syndecan-1 shedding, which does require activity of the enzyme. This suggests that two different functional domains within the heparanase enzyme (the enzyme active site and a separate site) contribute to events leading to enhanced HGF signaling. These findings demonstrate a novel mechanism driving the HGF pathway whereby heparanase stimulates an increase in both HGF expression and syndecan-1 shedding to enhance HGF signaling. This work also provides further mechanistic insight into the dynamic role of heparanase in driving aggressive tumor progression.
Hydrodynamic modelling and model sensitivities to bed roughness and bathymetry offset in a micro-tidal estuary (2020)

Abstract Tidal estuaries support everyday functions for over 80% of Australia's population living within 50 km of the coastline and thus come under immense pressure of physicochemical changes. Most studies in estuarine applications have used the bed roughness as the single calibration parameter to calibrate hydrodynamic modelling, yet errors in bathymetric data can significantly impose uncertainties into the model outputs. In this study, we evaluated the sensitivity of a hydrodynamic model of a micro-tidal estuary to both the bed roughness and bathymetry offset through comparing observed and modelled water level and velocity. Treating both bathymetry offset and bed roughness as calibration parameters, three calibration scenarios were tested to examine the impact of these parameters. To validate the model, Lagrangian drifter data as a new dataset in shallow estuaries were used. The analysis shows that model outputs are more sensitive to the variation of bathymetry offset than bed roughness. Results show that calibrating the bathymetry offset alone can significantly improve model performance. Simultaneous calibration of both parameters can provide further improvement, particularly for capturing the water level. Drifter and modelled velocities are highly correlated during flood tides, whereas the correlation is low for slack water because of wind-induced current on drifters.
Closing the Gap between the Multi-Channel and the Stereo Audio World: Recent MP3 Surround Extensions (2006)

Preprint 6754
Conjugates of Unsaturated Fatty Acids with Propylene Glycol as Potentially Less-Irritant Skin Penetration Enhancers (2007)

Fatty acids (FA) are well known as efficient enhancers for transdermal delivery of drugs; however, their frequent dermal toxicity limits their regular use. In order to utilize the fatty acid as a safe enhancer devoid of its irritant effect, we have synthesized and evaluated a series of fatty acids conjugated to propylene glycol (FA-PG). Each one of the conjugates was prepared as a mono- or di- acyl ester derivative. The effects of the synthetic enhancers on the porcine skin permeability were evaluated in a diffusion cell system using lidocaine as the model drug. In addition, in vivo examinations in rabbits were preformed for skin toxicological evaluation. The results indicate that among the FA-PG conjugates, oleic acid (C18:1(n-9))-PG, linoleic acid (C18:2(n-6))-PG and alpha-linolenic acid (C18:3(n-3))-PG, mono- or di-esters, enhance the penetration of lidocaine relatively to the vehicle (without enhancer). The conjugates of oleic acid (C18:1(n-9)) and linoleic acid (C18:2(n-6)) with PG have demonstrated a similar enhancing effect as the corresponding free fatty acids. Interestingly, although the mono- or the di- conjugates of alpha-linolenic acid (C18:3(n-3)) with PG enhanced the lidocaine flux as the other two fatty acid conjugates, they resulted in a reduced permeability as compared to the action of their free acid. In addition, the mono-conjugates of alpha-linolenic acid (C18:3(n-3)) with PG exhibited elevated skin irritation in rabbits (relative to the fatty acid alone) compared to the significantly reduced irritation of oleate-PG and linoeate-PG mono-conjugates. In conclusion, except saturated FA-PG and alpha-linolenic acid (C18:3(n-3)) - PG mono-conjugates, unsaturated fatty acids (e.g., oleic and linoleic acids) after conjugation to PG may be safe and effective enhancers for delivering topical drugs.
ChemInform Abstract: RING TRANSFORMATION OF URACILS TO 2‐PYRIDONES. HYDROLYSIS OF 6‐(2‐DIMETHYLAMINOVINYL)URACILS (1978)

Abstract (VII) erhalten, deren Anteile in Relation zu den Bedingungen diskutiert werden.
SYSTEMATIC ANALYSIS OF THE SALUTARY EFFECT OF ESTROGEN ON CARDIAC PERFORMANCE AFTER TRAUMA-HEMORRHAGE (2008)

Although 17beta-estradiol (estrogen) and estrogen receptor (ER) agonist administration after trauma-hemorrhage improves cardiac function, it remains unknown what the optimal estrogen or ER agonist dosage is to elicit this beneficial effect. To study this, the dose-dependent effects of estrogen, propylpyrazole triol (ER-alpha agonist), and diarylpropionitrile (DPN; ER-beta agonist) on heart performance (+dP/dt) were determined in sham rats and in experimental animals at the time of maximal bleedout (MBO) or at 2 h after trauma-hemorrhage. The results showed that estrogen and DPN induced dose-dependent increases in the maximal rate of left ventricular pressure increase (+dP/dt) in all groups, whereas propylpyrazole triol was ineffective at all doses. The maximal dose and the 50% effective dose of DPN were approximately 100-fold lower than those of estrogen. The half-life of estrogen in plasma was approximately 25 min in sham and MBO groups. A positive correlation between the estrogen-induced increase in +dP/dt and survival in MBO rats were observed. These results collectively suggest that the salutary effects of estrogen on cardiac performance are dose-dependent and mediated via ER-beta.
Integration of Interdigitated Electrodes in Split-Ring Resonator for Detecting Liquid Mixtures (2020)

A microwave microfluidic sensor for detecting binary liquid mixtures with a dielectric method at RF/microwave frequencies is presented in this article. The sensor is based on a split-ring resonator (SRR) that is implemented in a microstrip transmission line, with interdigitated electrodes (IDEs) being integrated into the ring for liquid detection. Based on the equivalent circuit of the IDE-SRR device and with a series of finite element simulations, the detection theory is developed, and the device design optimization is investigated. The validation measurements on water-isopropanol liquid mixtures with various concentrations show that the proposed IDE-SRR sensor has higher sensitivity than the previous standard SRR sensor. The IDE-SRR sensor is then used to detect two binary liquids, i.e., water-methanol mixtures and water-tetrahydrofuran mixtures. The measured effective permittivity results of the binary mixtures at RF/microwave frequency range are compared with the existing mixing models for binary dielectric mixtures at zero frequency.
Incremental Density-Based Clustering on Multicore Processors (2020)

The density-based clustering algorithm is a fundamental data clustering technique with many real-world applications. However, when the database is frequently changed, how to effectively update clustering results rather than reclustering from scratch remains a challenging task. In this work, we introduce IncAnyDBC, a unique parallel incremental data clustering approach to deal with this problem. First, IncAnyDBC can process changes in bulks rather than batches like state-of-the-art methods for reducing update overheads. Second, it keeps an underlying cluster structure called the object node graph during the clustering process and uses it as a basis for incrementally updating clusters wrt. inserted or deleted objects in the database by propagating changes around affected nodes only. In additional, IncAnyDBC actively and iteratively examines the graph and chooses only a small set of most meaningful objects to produce exact clustering results of DBSCAN or to approximate results under arbitrary time constraints. This makes it more efficient than other existing methods. Third, by processing objects in blocks, IncAnyDBC can be efficiently parallelized on multicore CPUs, thus creating a work-efficient method. It runs much faster than existing techniques using one thread while still scaling well with multiple threads. Experiments are conducted on various large real datasets for demonstrating the performance of IncAnyDBC.
<scp>W</scp>nt5<scp>A</scp> promotes an adaptive, senescent‐like stress response, while continuing to drive invasion in melanoma cells (2014)

Abstract We have previously shown that W nt5 A drives invasion in melanoma. We have also shown that W nt5 A promotes resistance to therapy designed to target the BRAF V600E mutation in melanoma. Here, we show that melanomas characterized by high levels of W nt5 A respond to therapeutic stress by increasing p21 and expressing classical markers of senescence, including positivity for senescence‐associated β ‐galactosidase ( SA ‐ β ‐gal), senescence‐associated heterochromatic foci ( SAHF ), H 3 K 9 M e chromatin marks, and PML bodies. We find that despite this, these cells retain their ability to migrate and invade. Further, despite the expression of classic markers of senescence such as SA ‐ β ‐gal and SAHF , these W nt5 A ‐high cells are able to colonize the lungs in in vivo tail vein colony‐forming assays. This clearly underscores the fact that these markers do not indicate true senescence in these cells, but instead an adaptive stress response that allows the cells to evade therapy and invade. Notably, silencing W nt5 A reduces expression of these markers and decreases invasiveness. The combined data point to W nt5 A as a master regulator of an adaptive stress response in melanoma, which may contribute to therapy resistance.
Oligo(vinylidene fluoride) Langmuir-Blodgett films studied by spectroscopic ellipsometry and the density functional theory (2008)

Thin films of amphiphilic vinylidene fluoride oligomers prepared by Langmuir-Blodgett deposition on silicone substrates were investigated by comparing experimental and theoretical mid-infrared (IR) spectra. The experimental spectra were obtained using infrared spectroscopic ellipsometry. Theoretical spectra were calculated using density functional theory. Excellent correspondence of major IR bands in both data sets shows that the molecular backbone is oriented with the long axis normal to the substrate plane. This is in contrast to poly(vinylidene fluoride) LB films, in which the polymer chains are parallel to the substrate.
Giardia and Vilém Dušan Lambl (2014)

Giardiasis is a neglected disease, which spreads worldwide from Arctic to Tropics. It affects nearly 2% of adults and 6% to 8% of children in developed countries worldwide. Nearly 33% of people in developing countries have had giardiasis. The disease is caused by a binucleated flagellated protozoan parasite Giardia lamblia (syn. G. intestinalis, G. duodenalis) that inhabits the small intestine in humans and the other mammals. Clinical giardiasis is varied and ranges from asymptomatic passage of cysts to abdominal cramps, nausea, acute or chronic diarrhea, malabsorption, weight loss, and failure of children to thrive in both subclinical and symptomatic disease. The first description of Giardia had been attributed to Antonie van Leeuwenhoek, who in his letter to the Royal Society in November 4, 1681 described presence of microorganisms in his stool. However, the first microscopic drawing of morphological characteristics identifying the parasite Giardia, was provided by Vilém Dušan Lambl in 1859 analysing stool of a child. V. D. Lambl is also famous for describing Lambl's excrescences (1856) and for introducing detection of bladder cancer using the analysis of cells present in urine (1856).
Osmotic Tolerance Limits and Effects of Cryoprotectants on Motility of Bovine Spermatozoa1 (2002)

This study was conducted to determine the osmotic properties of bull spermatozoa, including the effects of osmotic stress and cryoprotectant agent (CPA) addition and removal, on sperm motility. Semen from beef bulls was collected by electroejaculation and extended 1:3 in TL-Hepes containing 100 micro g/ml pyruvate and 6 mg/ml BSA. In solutions of 150-1200 mOsmolal (mOsm), bull spermatozoa behaved as linear osmometers (r(2) = 0.97) with an osmotically inactive cell volume of 61%. The isosmotic cell volume was 23.5 micro m(3). Motility was determined after exposure to anisosmotic solutions ranging from 35 to 2400 mOsm and after return to isosmotic conditions. Retention of at least 90% of isosmotic motility could be maintained only between 270-360 mOsm. Bull spermatozoa were calculated to retain 90% of their isosmotic motility at 92-103% of their isosmotic cell volume. Motility following a one-step addition and removal of 1 M glycerol, dimethyl sulfoxide, and ethylene glycol was reduced by 31%, 90%, and 6%, respectively, compared with CPA addition only. These data indicate that, during bull spermatozoa cryopreservation, osmotically driven cell volume excursions must be limited by exposure to a very narrow range that may be facilitated by the use of ethylene glycol as a CPA.