gebhart/patrepeval huggingface dataset:
Drug-Delivery By Ion-Exchnage. Part VII: Release of Acidic Drugs from Anionic Exchange Resinate Complexes (1990)

The loading and relase of ibuprofen, Ketoprofen and mefenamic acid from a range of strong anionic exchange resins, including cholestyramine, is decribed. Release rates into simulated gastric fluid increase with stirring speed up to 300 rpm and decrease as either the particle size of the resin beads of the degree of cross-linking increase. An increase in the temperature of loading enhances the capacity of the resin towards the drug and reduce its relase rate. Coating of the resing also enables suppression of drug release to be achieved. The samll particle size of cholestyramine enables a rapid relese of drug from the resin to be achieved. This rate is significantly greater than that obtained by monitoring dissolution from a drug-lactose dispersion and may indicate that ion-exchange technology may provide and opportunity to overcome poor dissolution characteristicsf for weekly ionic compounds.
Electrochemiluminescent metallopolymers for the detection of biological analytes (2007)

Electrochemiluminescence (ECL) represents a sensitive and potentially selective approach to detecting biomolecules ranging from DNA to protein and antibody biomarkers. ECL production is highly dependent upon the rate of charge transfer (DCT). Non-conjugated metallopolymers that have previously been reported for ECL production suffer from a relative slow rate of charge transfer compared to metallopolymers that support a π conjugated network along the polymer backbone. Here, we report on the development of ruthenium containing conjugated metallopolymers with enhanced rates of charge transfer for use in ECL production. These metallopolymers have been developed with conjugated backbones which have previously been shown to aid in the communication between adjacent metal centres. The electrochemiluminescent, electrochemical and photophysical properties of the metallopolymers have been extensively studied and are reported herein
&lt;title&gt;Sub-Oxide Thin Films For An Optical Recording Disk&lt;/title&gt; (1982)

Thin films of SbOx, GeOx, TeOx, MoOx, InOx and PbOx ( x is smaller than the stoichiometric value for each component ) were found to have a feasibility to be applied to an optical recording disc. Upon heating, these thin films are critically changed in their optical constants at 150°, 280°, 120°, 150°, 120° and 100°C, respectively. The contrast ratios before to after heat treatment of the GeOx, TeOx and MoOx films of 1000 - 2000 &Aring; thick are very high, they are 50, 20 and 15, respectively. Among them, the TeOx (x &asymp;1.1) film was excellent in both the sensitivity and the contrast ratio, and an optical recording disc was prepared by depositing the TeOx on a PMMA disc, substrate. Video-signals can be recorded and played back using a laser diode (&lambda; =8300 &Aring;, N.A.= 0.5) at the laser power of 6 - 8 mW incident. The carrier to noise ratio at 5 MHz was in excess of 55 dB.
Compositionally graded SS316 to C300 Maraging steel using additive manufacturing (2021)

Joining of dissimilar metals is required for numerous applications in industries such as chemical, energy and automotive. It is challenging due to differences in melting point, density, and thermal expansion of the metals being joined. Common welding techniques involve limiting melting and solidification to a narrow area leading to high thermal stresses and potentially brittle intermetallic phases. Furthermore, the geometric complexity of these welded joints can be rather limited. Additive Manufacturing (AM) presents new techniques for joining of dissimilar metals. One of the emerging methods is the building of functionally graded parts using Directed Energy Deposition (DED) to spatially vary composition. In this paper, a SS316 L and C300 maraging steel couple were joined by DED and heat treated. 13 discrete composition layers were selected using metallurgical considerations, in order to ensure a smooth transition in properties and microstructure. The mechanical properties of the as-built joints were found to be similar to the SS part and no intermetallic phases were found in the interface.
Reducing web crawler overhead using mobile crawler (2011)

To search any information on the web users extensively use the search engines. As the growth of the World Wide Web exceeded all expectations, the search engines rely on web crawlers to maintain the index of billions of pages for efficient searching. The web crawlers have to interact with millions of hosts and retrieve the pages continuously to keep the index up-to-date. It is reported in the literature that the 40% of the current Internet traffic and bandwidth consumption is due to these crawlers. These crawlers also cause load on the remote server by using its CPU cycles and memory. In addition, I/O performance, network resources, and OS limits must be taken into account in order to achieve high performance at a reasonable cost. This paper address all those problems by proposing a system based on mobile crawlers using mobile agent. The proposed approach employs mobile agents to crawl the pages. These mobile crawlers identify the modified pages at the remote site without downloading them instead it downloads those pages only, which have actually been modified since last crawl. Hence it will reduce the Internet traffic and load on the remote site considerably. This system can be implemented by the help of java aglets.
Carbenoxolone Blocks Endotoxin-Induced Protein Kinase R (PKR) Activation and High Mobility Group Box 1 (HMGB1) Release (2013)

Abstract The pathogen- and damage-associated molecular patterns (for example, bacterial endotoxin and adenosine 5′-triphosphate (ATP)) activate the double-stranded RNA-activated protein kinase R (PKR) to trigger the inflammasome-dependent high mobility group box 1 (HMGB1) release. Extracellular ATP contributes to the inflammasome activation through binding to the plasma membrane purinergic P2X 7 receptor (P2X 7 R), triggering the opening of P2X 7 R channels and the pannexin-1 (panx-1) hemichannels permeable for larger molecules up to 900 daltons. It was previously unknown whether panx-1 channel blockers can abrogate lipopolysaccharide (LPS)-induced PKR activation and HMGB1 release in innate immune cells. Here we demonstrated that a major gancao (licorice) component (glycyrrhizin, or glycyrrhizic acid) derivative, carbenoxolone (CBX), dose dependently abrogated LPS-induced HMGB1 release in macrophage cultures with an estimated IC 50 ≈ 5 µmol/L. In an animal model of polymicrobial sepsis (induced by cecal ligation and puncture (CLP)), repetitive CBX administration beginning 24 h after CLP led to a significant reduction of circulating and peritoneal HMGB1 levels, and promoted a significant increase in animal survival rates. As did P2X 7 R antagonists (for example, oxidized ATP, oATP), CBX also effectively attenuated LPS-induced P2X 7 R/panx-1 channel activation (as judged by Lucifer Yellow dye uptake) and PKR phosphorylation in primary peritoneal macrophages. Collectively, these results suggested that CBX blocks LPS-induced HMGB1 release possibly through impairing PKR activation, supporting the involvement of PKR in the regulation of HMGB1 release.
Antimicrobial systems of human whole saliva in relation to dental caries, cariogenic bacteria, and gingival inflammation in young adults (1988)

The association of salivary antibody (total IgA, IgG, and IgM and antibodies reactive with Streptococcus mutans) and non-antibody (lysozyme, lactoferrin, salivary peroxidase, myeloperoxidase, hypothiocyanite, thiocyanate) defense factors with oral health (past and present dental caries, gingival bleeding, the number of salivary S. mutans and lactobacilli) were studied in 50 naval recruits. Dental caries was significantly associated with large amounts of S. mutans, lactobacilli, and total salivary immunoglobulins and with low salivary flow rate and buffer capacity. Salivary anti-S. mutans antibodies did not correlate with dental caries or S. mutans levels. Moreover, none of the salivary non-antibody factors alone had any strong relationship to dental caries or S. mutans levels. Gingival inflammation was associated with elevated levels of lysozyme in whole saliva. It is concluded that in adults the associations between single-point measurements of most salivary antimicrobial constituents and the factors describing oral health are weak.
A Case of Lenvatinib-Induced Focal Segmental Glomerulosclerosis (FSGS) in Metastatic Medullary Thyroid Cancer (2018)

We describe a case of lenvatinib (E7080) associated focal segmental glomerulosclerosis (FSGS) encountered during the treatment of metastatic medullary thyroid cancer. Proteinuria is a relatively common side effect of VEGF-targeted treatments and can occasionally result in treatment discontinuation. Here, we describe a patient who developed secondary FSGS necessitating discontinuation of treatment at first but who was subsequently rechallenged with anti-VEGF-targeted treatment without recurrence of proteinuria. Lenvatinib was a novel experimental agent at the time the treatment took place; however, its recent licensing for the treatment of thyroid malignancies in the UK makes reporting of these adverse effects all the more important now.
Ship Detection from Optical Satellite Images with Deep Learning (2019)

The effective use and control of maritime routes in the commercial/military area is an increasing and important need for states. There are some motivations for this purpose: Safe traffic of the ships in narrow canals, avoiding illegal usage of anchoring areas of ships, monitoring fishing activities to avoid illegal fishing or protect fish population, detection of lost ships, boats or debris in the ocean, detection and identification of warships (intelligence, defense, offensive, etc.). This paper proposed an open source, fast running ship detection system from optical satellite images with the deep learning algorithm. The system does not need any comprehensive hardware, even can work on an average laptop. Tensorflow Object Detection Application Programming Interface (API)is trained by optical satellite images with ships and used as object detection API.
Investigating enhancement mode gallium nitride power FETs in high voltage, high frequency soft switching converters (2016)

An increased attention has been detected to develop smaller and lighter high voltage power converters in the range of 50V to 400V domain.The main applications for these converters are mainly focused for Power over Ethernet (PoE), LED lighting and AC adapters.This work will discuss a study of using enhancement mode gallium nitride switches to form a 50V quasi-square-wave zero-voltage-switching buck converter running at 2-6 MHz under full load.The designed converter achieved 83% efficiency converting 50V input voltage to 12.2V at 9W load.
Lack of high BMI-related features in adipocytes and inflammatory cells in the infrapatellar fat pad (IFP) (2017)

BMI-related features usually observed in SCAT and visceral adipose tissue could not be detected in the IFP of OA patients, a fat depot implicated in OA pathogenesis.
Mass spectrometry of secondary neutrals and ions for chemical analysis of salts (1991)

Abstract Complete characterization of solid environmental samples requires sensitive chemical analysis, which includes quantitation of elements, identiflcation of compounds and determination of their spatial distribution. In order to investigate the possible contribution to an analysis of microparticles collected from the atmosphere, plasma‐based secondary neutral mass‐spectrometry (SNMS) and SIMS were examined using salt samples as these are frequent components of such environmental materials. Chlorides, carbonates, nitrates and sulphates were bombarded with high fluxes of argon ions to meet the dynamic conditions for depth‐resolved analysis. This first application of plasma‐based SNMS to salts revealed that their neutral secondary emission mainly consists of those atoms or elements that the bombarded sample is composed of. Thus, mass analysis of the emitted atoms enables the identification of all elements and an example shows that elemental quantitation can be performed with a moderate matrix dependence. A small fraction of binary clusters within the total neutral emission offers compound‐specific information of compounds owing to the emission of characteristic polyatomic ions. Quantitation of the stoichimetry of complex sulphur anions was found to be rather less matrix‐dependent using negative SIMS than SNMS. Although dynamic bombardment inevitably induces chemical reactions, the results demonstrate that depth‐resolved analysis of salt‐containing samples, including elemental quantitation and chemical speciation, can be performed using SNMS and SIMS.
Realizing Trustworthy Business Services by a New GRC Approach (2009)

The trustworthiness of business services is widely recognised as a critical factor for the success of an organization. Businesses are increasing in complexity and unpredictability, while demand for accountability, as well as regulatory compliance is becoming mandatory. Yet, some reports indicate that the level of fraud within an organization is far from decreasing. Thus, a structured approach to Governance, Risk and Compliance (GRC) has become a high priority goal for many organizations. GRC solutions enable organizations to address various business challenges related to risk management and regulatory compliance. For example, GRC solutions provide end-to-end control management, deployment of controls through risk-based approaches and automatic monitoring of controls across different entities and applications. Furthermore, GRC solutions enable standardization of methodologies, vocabulary and measurements across an organization, therefore facilitating the detection of risks, the prioritization of corrective actions and so the enforcement of compliance.
Cerium Ion-Incorporated Titanium Metal Implants of Enhanced Bioactivity for Biomedical Applications (2023)

The enhancement in the performance of metallic bone implants based on commercially pure titanium (CP-Ti) by incorporation of cerium (Ce) ions onto the surface was evaluated. The incorporation of Ce ions onto the CP-Ti surface was carried out by a simple two-step chemical treatment method, where an initial NaOH treatment and then a subsequent treatment with different molar concentrations of ceric nitrate solution followed by heat treatment at 600 °C were carried out. The modified surfaces were observed using field emission scanning electron microscopy (FE-SEM), scanning electron microscopy-energy dispersive X-ray analysis (SEM-EDX), X-ray photoelectron spectroscopy (XPS), the laser Raman spectroscopic technique, high-resolution transmission electron microscopy (HR-TEM), and atomic force microscopy (AFM). The formation of a nanonetwork structure by the initial NaOH treatment and the replacement of Na ions with Ce ions along with different phases of TiO<sub>2</sub> was evident from the surface characterization results. The transition of rutile TiO<sub>2</sub> to anatase TiO<sub>2</sub> in the modified surface is evident from the Raman spectra with respect to the treatment of higher to lower concentrations of ceric nitrate solution. The presence of two different oxidation states of Ce (Ce<sup>3+</sup> and Ce<sup>4+</sup>) and improvement in the surface wettability were also distinct in the modified samples. Thus, the incorporated Ce ions over the nanostructured titania network showed low cytotoxicity, good cell adhesion, and enhanced extracellular mineralization on MG-63 cells with better protein adsorption in BSA medium. Taken together, the thus-improved nanostructured surface morphology with the anatase TiO<sub>2</sub> phase and distinct extracellular mineralization in the Ce-incorporated Ti metal with good biocompatibility make it a promising candidate for bone implant applications.
A multicenter randomized phase III trial of neo-adjuvant chemotherapy followed by surgery and chemotherapy or by surgery and chemoradiotherapy in resectable gastric cancer: First results from the CRITICS study. (2016)

4000 Background: The mainstay of potentially curative treatment of gastric cancer is radical surgical resection. Because most patients in the Western world present with advanced stages long-term survival remains poor at about 25%, with local recurrences as part of treatment failure in up to 80% of cases. Postoperative chemoradiotherapy (CRT) and perioperative chemotherapy (CT) have demonstrated a survival benefit over surgery alone. The current randomized phase III CRITICS-study (NCT00407186) investigated whether chemoradiotherapy after neo-adjuvant chemotherapy and adequate (D2) surgery leads to improved overall survival (OS) in comparison with postoperative chemotherapy. Furthermore, toxicity of both treatment regimens was explored. Methods: Patients with stage Ib-IVa resectable gastric cancer were randomized after diagnosis. Neo-adjuvant CT was prescribed in both arms and consisted of 3 courses of epirubicin, cisplatin/oxaliplatin and capecitabine (ECC/EOC). After gastric cancer resection, patients received another 3 courses of ECC/EOC or CRT (45 Gy in 25 fractions combined with weekly cisplatin and daily capecitabine). Primary endpoint is OS; secondary endpoints are: disease free survival, toxicity profile and quality of life. Results: Between January 2007 and April 2015, 788 patients from The Netherlands, Sweden and Denmark were randomized (393 CT; 395 CRT). Baseline characteristics were well balanced with 70% males and a median age of 61 years. 84% completed 3 cycles before surgery. In the CT arm 46% and in the CRT arm 55% completed treatment according to protocol. After a median follow-up of 50 months, 405 patients have died. The 5-year survival is 41.3% for CT and 40.9% for CRT (p=0.99). Toxicity was mainly hematological (grade III or higher: 44% vs 34%; p=0.01) and gastrointestinal (grade III or higher: 37% vs 42%; p=0.14) for CT and CRT, respectively. Conclusion: No significant difference in overall survival was found between postoperative chemotherapy and chemoradiotherapy. Clinical trial information: NCT00407186.
A comprehensive protein ressource for the study of bladder cancer: http://biobase.dk/cgi-bin/celis (1999)

In our laboratories we are exploring the possibility of using proteome expression profiles of fresh bladder tumors (transitional cell carcinomas, TCCs; squamous cell carcinomas, SCCs) and random biopsies as fingerprints to subclassify histopathological types and as a starting point to search for protein markers that may form the basis for diagnosis, prognosis, and treatment. Ultimately, the goal of these studies is to identify signaling pathways and components that are affected at various stages of bladder cancer progression and that may provide novel leads in drug discovery. Here we present our ongoing efforts to establish comprehensive two-dimensional polyacrylamide gel electrophoresis (2-D PAGE) databases of TCCs and SCCs which are being constructed based on the proteomic and immunohistochemical analysis of hundreds of fresh tumors, random biopsies and cystectomies received shortly after operation (http://biobase.dk/cgi-bin/celis).
Data from The Nonsignaling Extracellular Spacer Domain of Chimeric Antigen Receptors Is Decisive for &lt;i&gt;In Vivo&lt;/i&gt; Antitumor Activity (2023)

&lt;div&gt;Abstract&lt;p&gt;The use of synthetic chimeric antigen receptors (CAR) to redirect T cells to recognize tumor provides a powerful new approach to cancer immunotherapy; however, the attributes of CARs that ensure optimal &lt;i&gt;in vivo&lt;/i&gt; tumor recognition remain to be defined. Here, we analyze the influence of length and composition of IgG-derived extracellular spacer domains on the function of CARs. Our studies demonstrate that CD19-CARs with a long spacer from IgG4 hinge-CH2-CH3 are functional &lt;i&gt;in vitro&lt;/i&gt; but lack antitumor activity &lt;i&gt;in vivo&lt;/i&gt; due to interaction between the Fc domain within the spacer and the Fc receptor–bearing myeloid cells, leading to activation-induced T-cell death. We demonstrate that &lt;i&gt;in vivo&lt;/i&gt; persistence and antitumor effects of CAR-T cells with a long spacer can be restored by modifying distinct regions in the CH2 domain that are essential for Fc receptor binding. Our studies demonstrate that modifications that abrogate binding to Fc receptors are crucial for CARs in which a long spacer is obligatory for tumor recognition as shown here for a ROR1-specific CAR. These results demonstrate that the length and composition of the extracellular spacer domain that lacks intrinsic signaling function can be decisive in the design of CARs for optimal &lt;i&gt;in vivo&lt;/i&gt; activity. &lt;i&gt;Cancer Immunol Res; 3(2); 125–35. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
An Organophosphorus Pesticide, Chlorpyrifos, Increases the Levels of the Multidrug-Resistant Gene Product in Breast Cancer Cells. (1995)

Abstract : We originally proposed that chlorpyrifos, the widely used organophosphorus pesticide, induces the expression of the multidrug resistance (mdr) gene product in a manner similar to that of chemotherapeutic agents and may contribute to a MDR phenotype seen in untreated and relapsed breast cancer patients.
HYDROXYPYRIDINONES AND DESFERRIOXAMINE INHIBIT MACROPHAGE-MEDIATED LDL OXIDATION BY IRON BUT NOT BY COPPER (1993)

Conference Article| August 01 1993 HYDROXYPYRIDINONES AND DESFERRIOXAMINE INHIBIT MACROPHAGE-MEDIATED LDL OXIDATION BY IRON BUT NOT BY COPPER D. J. Lamb; D. J. Lamb 1Dept. of Biochemistry & Physiology, University of Reading, Whiteknights, Reading, London Search for other works by this author on: This Site PubMed Google Scholar R. C. Hider; R. C. Hider *Dept. of Pharmacy, King's College London, Manresa Road, London Search for other works by this author on: This Site PubMed Google Scholar D. S. Leake D. S. Leake 1Dept. of Biochemistry & Physiology, University of Reading, Whiteknights, Reading, London Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1993) 21 (3): 234S. https://doi.org/10.1042/bst021234s Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation D. J. Lamb, R. C. Hider, D. S. Leake; HYDROXYPYRIDINONES AND DESFERRIOXAMINE INHIBIT MACROPHAGE-MEDIATED LDL OXIDATION BY IRON BUT NOT BY COPPER. Biochem Soc Trans 1 August 1993; 21 (3): 234S. doi: https://doi.org/10.1042/bst021234s Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: DFO, desferrioxamine, HPO, 1,2-dimethyl-3-hydroxypyridin-4-one, LDL, low density lipoprotein This content is only available as a PDF. © 1993 Biochemical Society1993 Article PDF first page preview Close Modal You do not currently have access to this content.
Iridium-Catalyzed Arene <i>Ortho</i>-Silylation by Formal Hydroxyl-Directed C−H Activation (2010)

A strategy for the ortho-silylation of aryl ketone, benzaldehyde, and benzyl alcohol derivatives has been developed in which a hydroxyl group formally serves as the directing element for Ir-catalyzed arene C-H bond activation. One-pot generation of a (hydrido)silyl ether from the carbonyl compound or alcohol is followed by dehydrogenative cyclization at 80-100 °C in the presence of norbornene as a hydrogen acceptor and the combination of 1 mol % [Ir(cod)OMe]2 and 1,10-phenanthroline as a catalyst to form benzoxasiloles. The synthetic utility of the benzoxasilole products is demonstrated by conversion to phenol or biaryl derivatives by Tamao-Fleming oxidation or Hiyama cross-coupling. Both of these transformations of the C-H silylation products exploit the Si-O bond in the system and proceed by activation of the silyl moiety with hydroxide, rather than fluoride.