gebhart/patrepeval huggingface dataset:
TWO-YEAR DURABILITY OF BLOOD PRESSURE REDUCTION WITH CATHETER-BASED RENAL SYMPATHETIC DENERVATION: HT.3.04 (2010)

Background: Renal sympathetic hyperactivity is seminal in the progression of hypertension (HTN). Catheter-based renal sympathetic denervation (RDN) has been shown to significantly reduce blood pressure in patients with hypertension (HTN). Durability of effect at 2-years using this novel technique has never been reported. Methods: A cohort of 45 patients with resistant HTN (SBP ≥160 mmHg on ≥3 anti-HTN drugs, including a diuretic) was originally reported in the Lancet. We report longer term data on these patients and similar patients subsequently treated with the catheter-based renal denervation in non-randomized studies. Office blood pressure (BP) data and safety data were available at 1, 3, 6, 12, 18 and 24 months post-procedure. eGFR at 3 and 12 months were available. Results: 117 pts were treated with catheter-based RDN at 17 centers in Australia, Europe, and the US. Mean age was 57±11 yrs, 40% were female, 33% diabetic, 22% with CAD. Baseline values include mean office BP 176/98 ± 17/14 mmHg, mean of 5.0 anti-HTN medications, and eGFR 82 ± 19 mL/min. The procedure lasted a median of 38 minutes. Four acute procedural complications occurred: three groin pseudoaneurysms and one renal artery dissection, all managed without further sequelae. Post-procedure office BPs were reduced by 20/11, 24/10, 24/12, 25/12, 29/17, and 33/14 mmHg at 1, 3, 6, 12, 18, and 24 months respectively. At 3-months the eGFR had changed by -1.4 mL/min (95% CI: -4.6 to 1.7), and at 12-months the eGFR had changed by -2.8 mL/min (95% CI: -6.4 to 0.8). One patient required stenting of a renal artery ostial stenosis that was present at baseline but grew by 6 months; no radiofrequency energy had been delivered in this location. Otherwise, there were no late adverse events associated with the therapy. Conclusions: Catheter-based RDN results in a substantial reduction in BP sustained to at least 2 years, without significant adverse events, in patients with resistant HTN. The changes in eGFR are better than the natural history reported in similar patients.
Abstract 429: Reactive Oxygen Species Impair Endothelial Function and Perivascular Adipose Tissue Signaling in Mesenteric Arterioles From Ovariectomized Rats (2012)

Perivascular adipose tissue (PVAT) normally promotes vascular endothelium dependent relaxation (EDRs), whereas reactive oxygen species (ROS) impair endothelial function. However, the effects of the menopause on PVAT, and its interaction with ROS, are unexplored. We tested the hypothesis that ovariectomy (OVX) causes oxidative stress that impairs microvascular PVAT signaling. Mesenteric arterioles (MAs) were isolated from rats 4-6 weeks after sham-operation (Sham) or OVX. Alternate rats received vehicle or tempol (2mmol · 1 -1 of water) throughout (n=6/group). MAs were preconstricted with 10 -7 M norepinephrine for measurement of acetylcholine (ACh)-induced endothelial derived relaxation (EDR), endothelium derived relaxation factor (EDRF) and NO activity (DAF-FM fluorescence) using a Mulvany-Halperin wire myograph and fluorescence RatioMaster system. Other vessels were studied under spontaneous tone with dilator pathways blocked with 10 -4 M L-NAME, 10 -5 M apamine and 10 -6 M charybdotoxin to measure ACh-induced endothelium dependent contraction factor (EDCF) and ROS generation (temp-9AC fluorescence). OVX rats had vascular remodeling (midia: lumen diameter: 4.4± 0.4 vs 1.5 ± 0.3 μm·μm -1 , P&lt;0.01). Their MAs without PVAT had diminished EDR (48 ±5 vs 73±3%; P&lt;0.05), EDRF (20±4 vs 41±4%; P&lt;0.01) and NO activity (0.4 ± 0.1 vs 0.7± 0.1 units; P&lt;0.05) and developed an EDCF (23±6 vs 5±3%; P&lt;0.05) and ACh-induced ROS (0.5±0.1 vs 0.1±0.0 units; P&lt;0.01). The presence of PVAT surrounding Sham vessels enhanced EDR (90±3 vs 73±3%; P&lt;0.05), EDRF (57±3 vs 41±3%; P&lt;0.05) and NO (1.2±0.01 vs 0.7±0.1 units; P&lt;0.05). All of these beneficial effects of PVAT were lost in OVX rats. Four to six weeks of tempol drinking in OVX rats restored normal intrinsic vascular endothelial function and NO and restored all the beneficial effects of PVAT while preventing microvascular remodeling. In conclusion, OVX rats had microvascular remodeling and severe endothelial dysfunction ascribed to intrinsic vascular effects of ROS that summated with ROS-dependent interruption of a beneficial microvascular PVAT signaling pathway. Thus, therapeutic targets for menopausal vascular dysfunction should be expanded to include ROS and its extravascular actions on PVAT.
Drive Integration of Active Flying-Height Control Slider With Micro Thermal Actuator (2006)

To attain ultra-low flying height, we have developed a thermal flying-height control (TFC) slider that contains a micro-thermal actuator. Using the device, the magnetic spacing of these sliders can be controlled in situ during operation of the drive. A previous prototype had shown insufficient characteristics when evaluated at the component level. The purpose of this research is to develop an improved TFC slider and verify its drive-level feasibility. After designing analytically by simulation of heat transfer and thermal deformation, a prototype of the TFC device was fabricated. Component-level evaluation showed that the actuator characteristics met the requirements necessary for the development of drives with controllable flying-height sliders. Drive-level evaluations showed remarkable effectiveness in the TFC slider in reducing the magnetic spacing.
Two novel missense mutations of the OCTN2 gene (W283R and V446F) in a patient with primary systemic carnitine deficiency (2000)

Primary systemic carnitine deficiency (SCD) is an autosomal recessive disorder of fatty acid oxidation caused by defective cellular carnitine transport. The disease is characterized by metabolic derangement simulating Reye's syndrome, hypoglcaemia, progressive cardiomyopathy and skeletal myopathy. Recently, it was shown that SCD is caused by mutations in the organic cation/carnitine transporter OCTN2 (SLC22A5). We report two novel mutations, W283R and V446F, which are both missense mutations in an affected infant. In vitro expression studies demonstrated that both are actually function-loss mutations with virtually no uptake activity. This is the first report of compound heterozygosity for two missense mutations in a patient with SCD. Hum Mutat 15:118, 2000.
Topological Synthesis of Compliant Mechanisms Using Linear Beam Elements<sup>*</sup> (2000)

The design of compliant mechanisms poses certain unique challenges because such mechanisms should have adequate flexibility to undergo desired deformations under the action of applied forces and adequate stiffness to withstand external loading. The focus here is to generate the topology of a compliant mechanism starting from input/output force/displacement functional requirements and design constraints. Previous studies [[1] Ananthasuresh, G. K., Kota, S. and Gianchandani, Y. 1993. Systematic Synthesis of Microcompliant Mechanisms—Preliminary Results. Proc. 3d Natl. Conf. on Applied Mechanisms and Robotics. November1993, Cincinnati. Vol. 2, [Google Scholar] [2] Ananthasuresh, G. K., Kota, S. and Gianchandani, Y. June 1994. “A Methodical Approach to the Synthesis of Micro Compliant Mechanisms”. In Technical Digest, Solid-State Sensor and Actuator Workshop 189–192. Island, S. C.: Hilton Head. [Google Scholar] [3] Ananthasuresh, G. K., Kota, S. and Kikuchi, N. Strategies for Systematic Synthesis of Compliant MEMS, DSC. ASME Winter Annual Meeting. Nov.1994, Chicago. Vol. 55-2, [Google Scholar]] and [[4] Frecker, M. I., Ananthasuresh, G. K., Nishiwaki, S., Kikuchi, N. and Kota, S. 1997. Topological Synthesis of Compliant Mechanisms Using Multi-Criteria Optimization. J. Mech. Design, 119(2): 238–245. [Crossref], [Web of Science ®] , [Google Scholar]] employed a multi-criteria objective function comprised of mutual potential energy (MPE) and strain energy (SE) to full ground truss structures. Here an improved and robust objective function and its implementation for a network of linear beam elements is presented. Also discussed is the influence of various geometric and material variables on the objective function. Additionally, the objective function is interpreted in terms of physical design parameters such as mechanical advantage and geometric advantage.
Reverse Supply Chain Management - A study of two companies in the personal computer industry (2015)

Environmental regulations, increasing returns and legislative initiatives as well as the rapid\ndevelopment of new products forces companies in the personal computer industry to focus\nmore on their reverse flow. Reverse supply chain management (RSCM) is becoming more\nimportant to companies, from being seen as a nuisance, companies are starting to realize its\npotentials.\nThe purpose of this thesis was to investigate the role of RSCM and how economic value can\nbe captured in the reverse supply chain (RSC) in the personal computer industry, and to\nfulfill the purpose a multiple case study was conducted. To gain knowledge on the subject, a\nliterature review was made and interviews with managers at renowned manufacturers Hewlett\nPackard and Dell were carried out.\nThe results showed that economic value was captured through the reselling of used products\nbut time- and resource intensive activities were required in order to capture value. The two\ncompanies had different approaches to their respective RSC’s, mainly in terms of economy as\na driver and the execution of the RSC processes. Legislations and customer citizenships were\nconsidered drivers to the companies, forcing them to operate comprehensive take-back\nprograms.\nThe conclusions drawn from the findings are that keeping processes in-house comes with\nhigh initial costs, although increasing the potential to gain revenue in a long-term perspective.\nHP considered economy to be a driver and was also able to increase its revenue from\nreselling returned computers through different channels. Dell sees the reverse supply chain\nmore as a necessity than a potential source of revenue and has outsourced most of its\nactivities.
Effect of Electrical Stimulation Conditions on Neural Stem Cells Differentiation on Cross-Linked PEDOT:PSS Films (2021)

The ability to culture and differentiate neural stem cells (NSCs) to generate functional neural populations is attracting increasing attention due to its potential to enable cell-therapies to treat neurodegenerative diseases. Recent studies have shown that electrical stimulation improves neuronal differentiation of stem cells populations, highlighting the importance of the development of electroconductive biocompatible materials for NSC culture and differentiation for tissue engineering and regenerative medicine. Here, we report the use of the conjugated polymer poly(3,4-ethylenedioxythiophene) doped with polystyrene sulfonate (PEDOT:PSS CLEVIOS P AI 4083) for the manufacture of conductive substrates. Two different protocols, using different cross-linkers (3-glycidyloxypropyl)trimethoxysilane (GOPS) and divinyl sulfone (DVS) were tested to enhance their stability in aqueous environments. Both cross-linking treatments influence PEDOT:PSS properties, namely conductivity and contact angle. However, only GOPS-cross-linked films demonstrated to maintain conductivity and thickness during their incubation in water for 15 days. GOPS-cross-linked films were used to culture ReNcell-VM under different electrical stimulation conditions (AC, DC, and pulsed DC electrical fields). The polymeric substrate exhibits adequate physicochemical properties to promote cell adhesion and growth, as assessed by Alamar Blue® assay, both with and without the application of electric fields. NSCs differentiation was studied by immunofluorescence and quantitative real-time polymerase chain reaction. This study demonstrates that the pulsed DC stimulation (1 V/cm for 12 days), is the most efficient at enhancing the differentiation of NSCs into neurons.
Polypyrrole Growth on YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7-δ</sub> Modified with a Self-Assembled Monolayer of <i>N</i>-(3-Aminopropyl)pyrrole:  Hardwiring the “Electroactive Hot Spots” on a Superconductor Electrode (1996)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTPolypyrrole Growth on YBa2Cu3O7-δ Modified with a Self-Assembled Monolayer of N-(3-Aminopropyl)pyrrole: Hardwiring the "Electroactive Hot Spots" on a Superconductor ElectrodeRung-Kuang Lo, Jason E. Ritchie, Ji-Ping Zhou, Jianai Zhao, John T. McDevitt, Feng Xu, and Chad A. MirkinView Author Information Department of Chemistry and Biochemistry University of Texas at Austin, Austin, Texas 78712 Department of Chemistry, Northwestern University 2145 Sheridan Road, Evanston, Illinois 60208 Cite this: J. Am. Chem. Soc. 1996, 118, 45, 11295–11296Publication Date (Web):November 13, 1996Publication History Received1 April 1996Published online13 November 1996Published inissue 13 November 1996https://pubs.acs.org/doi/10.1021/ja9610343https://doi.org/10.1021/ja9610343rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views293Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Electrodes,Monolayers,Polymers,Pyrroles,Superconductors Get e-Alerts
OS Fingerprinting: New Techniques and a Study of Information Gain and\n Obfuscation (2017)

Passive operating system fingerprinting reveals valuable information to the\ndefenders of heterogeneous private networks; at the same time, attackers can\nuse fingerprinting to reconnoiter networks, so defenders need obfuscation\ntechniques to foil them. We present an effective approach for passive\nfingerprinting that uses data features from TLS as well as the TCP/IP and HTTP\nprotocols in a multi-session model, which is applicable whenever several\nsessions can be observed within a time window. In experiments on a real-world\nprivate network, our approach identified operating system major and minor\nversions with accuracies of 99.4% and 97.5%, respectively, and provided\nsignificant information gain. We also show that obfuscation strategies can\noften be defeated due to the difficulty of manipulating data features from all\nprotocols, especially TLS, by studying how obfuscation affects our\nfingerprinting system. Because devices running unpatched operating systems on\nprivate networks create significant vulnerabilities, their detection is\ncritical; our approach achieved over 98% accuracy at this important goal.\n
Study of Stabilization Design for On-Board Distributed Power Architecture (2006)

The bus architecture consisting of bus converter and Point of Load (POL) is generally used as distributed power supply system for IT infrastructure equipments. The most important factor is the system stability in bus architecture design. The overlap between the output impedance of bus converter and input impedance of POL causes system instability, and it has been an actual problem. Increasing the bus capacitor, system stability can be reduced easily. However, due to the limited space on the system board, increasing of bus capacitors is impractical. The urgent solution of the issue is desired strongly. This paper presents the stability design for on-board distributed power system consisting of full-regulated bus converter and POLs. The output impedance of the bus converter and the input impedance of the POL are analyzed, and it is conformed by experimentally for stability criterion. As a result, the standard of the discrimination of stability on a frequency response of input and output impedance is clarified. Furthermore, the design process for system stability is proposed.
Integrated STEM Education: A Systematic Review of Instructional Practices in Secondary Education (2018)

The shortage of graduates in Science, Technology, Engineering and Mathematics (STEM), has led to numerous attempts to increase students' interest in STEM. One emerging approach that has the potential to improve students' motivation for STEM is integrated STEM education. Nonetheless, the implementation of this new instructional strategy is not straightforward due to the lack of consensus about instructional practices in integrated STEM. This paper contributes to this challenge by providing a well-defined framework for instructional practices in integrated STEM in secondary education, based on the results of a systematic review of existing literature. The framework contains five key principles: integration of STEM content, problem-centered learning, inquiry-based learning, design-based learning and cooperative learning. The proposed framework has several benefits, including its applicability in the classroom and the possibility to describe integrated STEM on multiple dimensions. Nonetheless, further research is necessary to investigate the effects of integrated STEM on students' cognitive and affective learning outcomes.
Vaccination with<i>Bordetella pertussis</i>-Pulsed Autologous or Heterologous Dendritic Cells Induces a Mucosal Antibody Response In Vivo and Protects against Infection (2001)

This study demonstrates for the first time that vaccination with either autologous or heterologous dendritic cells (DC) pulsed with specific antigen induces protective immune responses against noninvasive bacteria, namely Bordetella pertussis. The DC-mediated protection is associated with strong B. pertussis-specific immunoglobulin G (IgG) and IgA responses in the lung.
Audio analysis for surveillance applications (2006)

We proposed a time series analysis based approach for systematic choice of audio classes for detection of crimes in elevators in R. Radhakrishnan et al. (2005). Since all the different sounds in a surveillance environment cannot be anticipated, a surveillance system for event detection cannot completely rely on a supervised audio classification framework. In this paper, we propose a hybrid solution that consists two parts; one that performs unsupervised audio analysis and another that performs analysis using an audio classification framework obtained from off-line analysis and training. The proposed system is capable of detecting new kinds of suspicious audio events that occur as outliers against a background of usual activity. It adaptively learns a Gaussian mixture model (GMM) to model the background sounds and updates the model incrementally as new audio data arrives. New types of suspicious events can be detected as deviants from this usual background model. The results on elevator audio data are promising.
Structural and magnetic properties of CuFe2O4 as-prepared and thermally treated spinel nanoferrites (2015)

The copper based CuFe 2 O 4 nanoferrite was prepared by chemical co-precipitation method and the detailed investigation of structural and magnetic properties was carried out successfully at room temperature. The obtained results from XRD confirm that CuFe 2 O 4 has tetragonal structure at room temperature and its crystallite size, lattice strain was found to be varied from 11 to 17 nm and 3.910 -2 to 2.610 -2 for microwave annealed to as-prepared samples calculated using Scherrer equation and Williamson-Hall analysis, respectively. A clear superparamagnetic behaviour was observed in as-prepared and hot air oven annealed nanoferrite samples at RT under the field range of ±2 T. A distorted superparamagnetic curve was determined from isothermal magnetic hysteresis studies for the microwave oven annealed sample. It might be a possible magnetic and non-magnetic cation transformation on the surface of CuFe 2 O 4 nanoparticles along with high lattice strain resulting in change of magnetic properties under certain level of applied magnetic field.
Structural basis of the junctional anchorage of the cerebral cavernous malformations complex (2012)

The products of genes that cause cerebral cavernous malformations (CCM1/KRIT1, CCM2, and CCM3) physically interact. CCM1/KRIT1 links this complex to endothelial cell (EC) junctions and maintains junctional integrity in part by inhibiting RhoA. Heart of glass (HEG1), a transmembrane protein, associates with KRIT1. In this paper, we show that the KRIT1 band 4.1, ezrin, radixin, and moesin (FERM) domain bound the HEG1 C terminus (K(d) = 1.2 µM) and solved the structure of this assembly. The KRIT1 F1 and F3 subdomain interface formed a hydrophobic groove that binds HEG1(Tyr(1,380)-Phe(1,381)), thus defining a new mode of FERM domain-membrane protein interaction. This structure enabled design of KRIT1(L717,721A), which exhibited a >100-fold reduction in HEG1 affinity. Although well folded and expressed, KRIT1(L717,721A) failed to target to EC junctions or complement the effects of KRIT1 depletion on zebrafish cardiovascular development or Rho kinase activation in EC. These data establish that this novel FERM-membrane protein interaction anchors CCM1/KRIT1 at EC junctions to support cardiovascular development.
Design and Intervention in the Age of "No Alternative" (2018)

This paper explores the relationship between design and intervention, and how scholars of computing and design might strengthen their repertoire of intervention amidst a pervasive sense of there being "no alternative" to structures of inequality and capitalist expansion. Drawing from the authors' long-term ethnographic research on maker, entrepreneurship, and innovation cultures as well as their engagements with professional communities of computing and design, this paper introduces and theorizes modes of intervention that do not fit familiar images of political action such as the countercultural hero or localized resistance. The paper contributes by expanding the analytical repertoire of an interventionist-oriented social computing scholarship. Specifically, it offers three inter-related analytical sensibilities from feminist and critical race studies-"noticing differently," "walking alongside" and "parasitic resistance"- to support political and activist approaches in CSCW and related fields
A Convergence Study of Multimaterial Mesh-based Surface Tracking (2014)

We report the results from experiments on the convergence of the multimaterial mesh-based surface tracking method introduced by the same authors. Under mesh refinement, approximately first order convergence or higher in L1 and L2 is shown for vertex positions, face normals and non-manifold junction curves in a number of scenarios involving the new operations proposed in the method.