gebhart/patrepeval huggingface dataset:
Joint Method of Moments (JMoM) and Successive Moment Cancellation (SMC) Multiuser Time Synchronization for ZP-OFDM-Based Waveforms Applicable to Joint Communication and Sensing (2023)

It has been recently shown that zero padding (ZP)-orthogonal frequency-division multiplexing (OFDM) is a promising candidate for 6G wireless systems requiring joint communication and sensing. In this paper, we consider a multiuser uplink scenario where users are separated in power domain, i.e., non-orthogonal multiple access (NOMA), and use ZP-OFDM signals. The uplink transmission is grant-free and users are allowed to transmit asynchronously. In this setup, we address the problem of time synchronization by estimating the timing offset (TO) of all the users. We propose two non-data-aided (NDA) estimators, i.e., the joint method of moment (JMoM) and the successive moment cancellation (SMC), that employ the periodicity of the second order moment (SoM) of the received samples for TO estimation. Moreover, the coding assisted (CA) version of the proposed estimators, i.e., CA-JMoM and CA-SMC, are developed for the case of short observation samples. We also extend the proposed estimators to multiuser multiple-input multiple-output (MIMO) systems. The effectiveness of the proposed estimators is evaluated in terms of lock-in probability under various practical scenarios. Simulation results show that the JMoM estimator can reach the lock-in probability of one for the moderate range of Eb/N0 values. While existing NDA TO estimators in the literature either offer low lock-in probability, high computational complexity that prevents them from being employed in MIMO systems, or are designed for single-user scenarios, the proposed estimators in this paper address all of these issues.
A new concept of the fiber composition of cervical spinal dura mater: an investigation utilizing the P45 sheet plastination technique (2022)

At the CVJ, the posterior wall of the SDM is a multi-layered structure composed of three different originated fibers. The cerebral dura mater, the periosteum located at the brim of the foramen magnum, and MDB contribute to the formation of the SDM. The present study would be beneficial to the choice of surgical approach at the CVJ and the protection of the SDB.
Age-Associated Decline in Effective Immune Synapse Formation of CD4+ T Cells Is Reversed by Vitamin E Supplementation (2007)

Aging is associated with reduced IL-2 production and T cell proliferation. Vitamin E supplementation, in aged animals and humans, increases cell division and IL-2 production by naive T cells. The immune synapse forms at the site of contact between a T cell and an APC and participates in T cell activation. We evaluated whether vitamin E affects the redistribution of signaling proteins to the immune synapse. Purified CD4(+) T cells, from the spleens of young and old mice, were treated with vitamin E before stimulation with a surrogate APC expressing anti-CD3. Using confocal fluorescent microscopy, we observed that CD4(+) T cells from old mice were significantly less likely to recruit signaling proteins to the immune synapse than cells from young mice. Vitamin E increased the percentage of old CD4(+) T cells capable of forming an effective immune synapse. Similar results were found following in vivo supplementation with vitamin E. When compared with memory cells, naive T cells from aged mice were more defective in immune synapse formation and were more responsive to vitamin E supplementation. These data show, for the first time, that vitamin E significantly improves age-related early T cell signaling events in naive CD4(+) T cells.
Efficacy of cyclosporin A in systemic sclerosis. (1991)

In this open pilot study, the potential therapeutic efficacy of Cyclosporin A (CsA) in systemic sclerosis (scleroderma) was investigated. Eight patients with severe scleroderma (skin manifestation and at least three organ manifestations such as pulmonary, intestinal, cardiac, renal, and severe hypertension) were included in the study. CsA administration was started at a dose of 5 mg per kg body weight per day and then, to obtain whole blood levels of 300-500 ng/ml, adjusted to a mean dosage of 4.3 mg/kg/day. Therapeutic effects were evaluated by monitoring the measures of cutaneous, pulmonary, cardiac, gastrointestinal, and renal involvement as well as laboratory parameters. After 6 to 12 months of CsA-administration, cutaneous abnormalities improved in seven, arterial oxygen tension slightly increased in four, pulmonary hypertension decreased in five, and smooth muscle esophageal contraction amplitudes improved in three patients. However, the disease progressed in one patient. No serious side effects were observed, and occurring renal side effects were mild. Taken together, these observations indicate that CsA administration may be effective mainly in the skin involvement, but also in some organ manifestations of scleroderma. The results of this pilot investigation therefore indicate that a controlled study of the efficacy of CsA in scleroderma is needed and ought to be performed.
Design and experimental evaluation of a distributed time synchronization technique for multi-hop wireless sensor networks (2017)

All communications networks, in general, and Wireless Sensor Networks (WSNs), in particular, need time synchronization for fulfilling the stringent requirements of the services they are providing. Time synchronization in WSNs is needed for multiple purposes (e.g., sleep-wakeup scheduling, event detection annotation). In literature, various time synchronization protocols for WSNs are proposed and some of these designs are evaluated in experimental testbeds. However, multi-hop time synchronization in WSNs have never been investigated experimentally. Therefore, to fill the gap in the WSN literature, in this study, we present the design and implementation of a novel time synchronization technique. Furthermore, we investigate the performance of the proposed technique through direct experimentation. Our results reveal the superior performance of our technique.
A Transition Metric in Polar Co-ordinates for MLSE of a Complex Modulated DML (2020)

We propose a metric for MLSE-Viterbi differential decoding of complex modulation of directly modulated lasers (CM-DML) that reports SNR gains of 1.8 dB at BER=10 − 3 on a simulated PAM4 signal with a typical linewidth enhancement factor α = 4
High-resolution imaging enabled by 100-kW-peak-power parametric source at 5.7 THz (2023)

Similar to x-ray imaging, THz imaging will require high power and high resolution to advance relevant applications. Previously demonstrated THz imaging usually experiences one or several difficulties in insufficient source power, poor spectral tunability, or limited resolution from a low-wavelength source. A short-wavelength radiation source in the 5-10 THz is relatively scarce. Although a shorter wavelength improves imaging resolution, widely used imaging sensors, such as microbolometers, Schottky diodes, and photoconductive antennas, are usually not sensitive to detect radiation with frequencies above 5 THz. The radiation power of a high-frequency source becomes a key factor to realize low-noise and high-resolution imaging by using an ordinary pyroelectric detector. Here, we report a successful development of a fully coherent, tunable, > 100-kW-peak-power parametric source at 5.7 THz. It is then used together with a low-cost pyroelectric detector for demonstrating high-resolution 5.7-THz imaging in comparison with 2-THz imaging. To take advantage of the wavelength tunability of the source, we also report spectrally resolved imaging between 5.55 and 5.87 THz to reveal the spectroscopic characteristics and spatial distribution of a test drug, Aprovel.
Hydrozirconation and Further Transmetalation Reactions (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
4 Transgenic porcine model reveals two roles for LGR5 in lung development and homeostasis (2021)

Reproduction, Fertility and Development is an international journal publishing original research , review and comment in the fields of reproduction and developmental biology in humans, domestic animals and wildlife
Anomalous Products from Intramolecular Insertion Reactions of Rhodium Carbenoids into the α-C−H Bonds of Ethers (1997)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTAnomalous Products from Intramolecular Insertion Reactions of Rhodium Carbenoids into the α-C−H Bonds of EthersJ. Stephen Clark, Alexander G. Dossetter, C. Adam Russell, and William G. WhittinghamView Author Information Department of Chemistry, University of Nottingham, University Park, Nottingham NG7 2RD, United Kingdom ZENECA Agrochemicals, Jealott's Hill Research Station, Bracknell, Berkshire RG42 6ET, United Kingdom Cite this: J. Org. Chem. 1997, 62, 15, 4910–4911Publication Date (Web):July 25, 1997Publication History Received12 May 1997Published online25 July 1997Published inissue 1 July 1997https://pubs.acs.org/doi/10.1021/jo970842phttps://doi.org/10.1021/jo970842prapid-communicationACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views392Altmetric-Citations32LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Catalysts,Cyclization,Ethers,Insertion reactions,Ketones Get e-Alerts
Scalable Bid Landscape Forecasting in Real-Time Bidding (2020)

In programmatic advertising, ad slots are usually sold using second-price (SP) auctions in real-time. The highest bidding advertiser wins but pays only the second-highest bid (known as the winning price). In SP, for a single item, the dominant strategy of each bidder is to bid the true value from the bidder's perspective. However, in a practical setting, with budget constraints, bidding the true value is a sub-optimal strategy. Hence, to devise an optimal bidding strategy, it is of utmost importance to learn the winning price distribution accurately. Moreover, a demand-side platform (DSP), which bids on behalf of advertisers, observes the winning price if it wins the auction. For losing auctions, DSPs can only treat its bidding price as the lower bound for the unknown winning price. In literature, typically censored regression is used to model such partially observed data. A common assumption in censored regression is that the winning price is drawn from a fixed variance (homoscedastic) uni-modal distribution (most often Gaussian). However, in reality, these assumptions are often violated. We relax these assumptions and propose a heteroscedastic fully parametric censored regression approach, as well as a mixture density censored network. Our approach not only generalizes censored regression but also provides flexibility to model arbitrarily distributed real-world data. Experimental evaluation on the publicly available dataset for winning price estimation demonstrates the effectiveness of our method. Furthermore, we evaluate our algorithm on one of the largest demand-side platforms and significant improvement has been achieved in comparison with the baseline solutions.
Optical Fabrication Laboratory: Introductory Training for Optical Engineering Students (1992)

Students in the BS and MS programs at The Institute of Optics may elect to take a one-semester laboratory course, taught by a master optician, which introduces them to optical glasses and the classical techniques for fabricating optical components. Over the past few years, several projects and new pieces of testing equipment have been added to the laboratory in order to expose optical engineering students to modern fabrication issues not previously covered. Students now investigate subjects such as glass melting and forming, the evolution of stress-birefringence during annealing, the relationship between a glass type's optical properties and its ease of fabrication, the estimation and measurement of subsurface damage, and new instruments for determining the figure and smoothness of finished parts. This paper describes some of the projects in the laboratory and gives examples of results generated by the students during the 12 three-hour laboratory sessions held weekly throughout the semester.
Pharmacological characterization of the mechanism of action leading to synergism between glycopyrronium bromide and indacaterol fumarate (2016)

<b>Background</b> Nowadays there is a considerable gap in knowledge concerning the mechanism(s) by which long-acting β<sub>2</sub> agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) interact to induce bronchodilation. <b>Aim</b> This study aimed to identify the mechanism(s) causing the synergistic interaction between the LAMA glycopyrronium bromide (GLY) and the LABA indacaterol fumarate (IND) in human bronchial tissue. <b>Methods</b> The influence of GLY plus IND was assessed on the release of acetylcholine (ACh) and concentrations of cAMP in human isolated airways. Iberiotoxin (IbTX, 100 nM) was used to block the KCa<sup>++</sup> channels, tetanus toxin (TeTX, 10 nM) to inhibit the synaptic vesicle exocytosis of ACh, and quinine (100 μM) to reduce the release of non-neurogenic ACh. <b>Results</b> The co-administration of GLY and IND reduced the release of ACh from epithelial cells (-36.6±4.7%, P&lt;0.01 vs. control) but not from bronchi, and enhanced cAMP levels in both bronchi (+479.4±62.4%, P&lt;0.01 vs. control) and epithelial cells (+29.1±7.1, P&lt;0.05 vs. control), an effect that was inhibited by IbTX. TeTX inhibited the release of parasympathetic ACh (−60.0%±1.2%, P&lt;0.001 vs. control), and both GLY and IND further enhanced this effect (−68.4%±1.8%, P&lt;0.001 vs. control). Quinine did not influence (P&gt;0.05) the effectiveness of GLY/IND combination in reducing the non-neurogenic release of ACh. <b>Conclusions</b> GLY/IND co-administration leads to a synergistic improvement of bronchodilation by increasing cAMP concentrations in both airway smooth muscle and bronchial epithelium and by decreasing ACh release from the epithelium.
Des images médicales au patient numérique (2015)

L’imagerie médicale computationnelle conçoit des logiciels d’analyse et de simulation des images qui permettent de construire un modèle numérique du patient pour assister le diagnostic, le pronostic et la pratique thérapeutique. Les images médicales, les organes virtuels personnalisés, la réalité virtuelle et augmentée, la simulation d’interventions, la thérapie guidée par l’image et assistée par la robotique font partie des outils informatisés qui préfigurent la médecine computationnelle de demain, au service du médecin et du patient.
A balanced translocation truncates Neurotrimin in a family with intracranial and thoracic aortic aneurysm (2012)

Background Balanced chromosomal rearrangements occasionally have strong phenotypic effects, which may be useful in understanding pathobiology. However, conventional strategies for characterising breakpoints are laborious and inaccurate. We present here a proband with a thoracic aortic aneurysm (TAA) and a balanced translocation t(10;11) (q23.2;q24.2). Our purpose was to sequence the chromosomal breaks in this family to reveal a novel candidate gene for aneurysm. Methods and results Intracranial aneurysm (IA) and TAAs appear to run in the family in an autosomal dominant manner: After exploring the family history, we observed that the proband9s two siblings both died from cerebral haemorrhage, and the proband9s parent and parent9s sibling died from aortic rupture. After application of a genome-wide paired-end DNA sequencing method for breakpoint mapping, we demonstrate that this translocation breaks intron 1 of a splicing isoform of Neurotrimin at 11q25 in a previously implicated candidate region for IAs and AAs (OMIM 612161). Conclusions Our results demonstrate the feasibility of genome-wide paired-end sequencing for the characterisation of balanced rearrangements and identification of candidate genes in patients with potentially disease-associated chromosome rearrangements. The family samples were gathered as a part of our recently launched National Registry of Reciprocal Balanced Translocations and Inversions in Finland (n=2575), and we believe that such a registry will be a powerful resource for the localisation of chromosomal aberrations, which can bring insight into the aetiology of related phenotypes.
A Thermodynamic Correlation for the Minimum Miscibility Pressure in CO2 Flooding of Petroleum Reservoirs (1988)

Summary A graphic equation-of-state (EOS)-generated correlation for the minimum miscibility pressure (MMP) of CO2/crude-oil displacements is presented, along with a brief review of 17 other MMP correlations. The MMP is estimated as the cricondenbar or first-contact miscibility pressure of the pure or impure CO2/crude-oil system in which the C5+ oil fraction is modeled as a single normal alkane of equivalent molecular weight. The correlation accounts for all the experimentally observed trends in MMP in a consistent manner and is independent of any CO2/crude-oil data base. A correction is introduced, however, to prevent a predicted increase in the MMP with decreasing temperature at low temperatures for high-molecular-weight oils. The average predicted-MMP/experimental-MMP ratio for 157 CO2/crude-oil MMP values is 1.09, with a standard deviation of 0.19. Unlike other correlations, specifically those relating MMP with CO2 density, a decrease in MMP with temperature at elevated temperatures (&amp;gt; 120°C [&amp;gt; 248°F]) is predicted.
ChemInform Abstract: An Investigation of the Mode of Formation of the 10‐P‐5 Protonated Phosphatrane HP(OCH2CH2)3N+. (1987)

Abstract Triethanolamine (I) reacts with the phosphorus compound (II) to yield (III) which forms the protonated phosphatrane (V) on subsequent addition of (IV).
Expression Profiling of Long Noncoding RNA Splice Variants in Human Microvascular Endothelial Cells: Lipopolysaccharide Effects<i>In Vitro</i> (2017)

Endothelial cell interactions with lipopolysaccharide (LPS) involve both activating and repressing signals resulting in pronounced alterations in their transcriptome and proteome. Noncoding RNAs are now appreciated as posttranscriptional and translational regulators of cellular signaling and responses, but their expression status and roles during endothelial interactions with LPS are not well understood. We report on the expression profile of long noncoding (lnc) RNAs of human microvascular endothelial cells in response to LPS. We have identified a total of 10,781 and 8310 lncRNA transcripts displaying either positive or negative regulation of expression, respectively, at 3 and 24 h posttreatment. A majority of LPS-induced lncRNAs are multiexonic and distributed across the genome as evidenced by their presence on all chromosomes. Present among these are a total of 44 lncRNAs with known regulatory functions, of which 41 multiexonic lncRNAs have multiple splice variants. We have further validated splice variant-specific expression of EGO (NONHSAT087634) and HOTAIRM1 (NONHSAT119666) at 3 h and significant upregulation of lnc-IL7R at 24 h. This study illustrates the genome-wide regulation of endothelial lncRNA splice variants in response to LPS and provides a foundation for further investigations of differentially expressed lncRNA transcripts in endothelial responses to LPS and pathophysiology of sepsis/septic shock.
Biomimetic smart nanocomposite:<i>in vitro</i>biological evaluation of zein electrospun fluorescent nanofiber encapsulated CdS quantum dots (2012)

New hybrid quantum dot (QD)/nanofibers have potential applications in a variety of fields. A novel fluorescent nanocomposite nanofiber material, consisting of CdS and zein has been fabricated through the electrospinning process. A detailed optimization was carried out to fabricate continuous and uniform nanofibers without beads or droplets. The synthesized hybrid nanofibers were characterized by various state-of-the-art techniques such as scanning electron microscopy, transmission electron microscopy (TEM), TEM-energy dispersive spectrometry, atomic force microscopy and confocal fluorescence micrography. The optimization process was carried out to fabricate fibers ranging from 200 to 450 nm in diameter. The electrical conductivity of the zein-CdS hybrid nanofiber substrates was tested. The potential use of the electrospun CdS-encapsulated nanofibrous scaffold as substrates for cell/tissue culture was evaluated with two different cell types, i.e. mesenchymal stem cells and fibroblasts. The results showed that the electrospun fibrous scaffolds could support the attachment and the proliferation of cells. In addition, the cells cultured on the fibrous scaffolds exhibited normal cell shapes and integrated well with surrounding fibers. The obtained results confirmed the potential for the use of the electrospun QD-encapsulated fluorescent nanofiber mats as scaffolds for tissue engineering.
PhastSystem electrophoresis in β-octylglucoside containing gels with immunodetection of a nondenatured vesicle-associated membrane protein (1999)

Recombinant vesicle-associated membrane protein (rVAMP), implicated as a participant in membrane exocytosis and fusion (a "SNARE protein"), was subjected to gel electrophoresis in the miniaturized gels of the PhastSystem (Pharmacia) containing the nondenaturing, nonionic detergent beta-octylglucoside (OG), followed by immunodetection of the protein. Three major components of nondenatured rVAMP are detected by Western blotting both in 0.5% OG and in the absence of detergent. Their separation increases with increasing gel concentration above 7%T. Ferguson plot analysis indicates that the three species of VAMP are size isomers (i.e., they differ in size but share a common surface net charge density), the common point of intersection of the plots (mu-point) being a measure of their common free mobility. By the criteria of size and free mobility (related to surface net charge), VAMP components I, II and III in 0.5% OG-containing buffer are indistinguishable from components II, III and IV, respectively, observed in the absence of the detergent. The feasibility of immunodetection of nondenatured rVAMP on gels containing nondenaturing detergents opens up the possibility of gaining biochemical information regarding nondenatured SNARE protein complexes and SNARE proteins linked to membrane fragments.