gebhart/patrepeval huggingface dataset:
An in vitro study of the effects of Doppler angle, fibrinogen, and hematocrit on ultrasonic Doppler power (1999)

For a better understanding of the relationship between the Doppler power and erythrocyte aggregation of whole blood under steady flow in a conduit, the effects of Doppler angle, fibrinogen concentration, and hematocrit were investigated in a mock flow loop. The results show that, at a mean shear rate of 102 s(-1), there was minimal angular dependence; but at a mean shear rate of 52 s(-1), there was a weak angular dependence as the Doppler angle was varied from 40 degrees to 70 degrees . These results suggest that there was, perhaps, no or little alignment of the red cell aggregates at high shear rates. The Doppler power was found to increase nonlinearly as the fibrinogen concentration was increased; and the effect of other plasma proteins on red cell aggregation may not be negligible, although fibrinogen is the dominant factor. The results show that the variation of the Doppler power over the lumen is hematocrit dependent for hematocrits below 26%
Synthesis of POSS-functionalized liquid crystalline block copolymers<i>via</i>RAFT polymerization for stabilizing blue phase helical soft superstructures (2018)

A study of the phase transition behaviors of blue phase liquid crystals containing different amounts of POSS-functionalized LC BCPs.
Fast Gate-Based Readout of Silicon Quantum Dots Using Josephson Parametric Amplification (2020)

Spins in silicon quantum devices are promising candidates for large-scale quantum computing. Gate-based sensing of spin qubits offers a compact and scalable readout with high fidelity, however, further improvements in sensitivity are required to meet the fidelity thresholds and measurement timescales needed for the implementation of fast feedback in error correction protocols. Here, we combine radio-frequency gate-based sensing at 622 MHz with a Josephson parametric amplifier, that operates in the 500-800 MHz band, to reduce the integration time required to read the state of a silicon double quantum dot formed in a nanowire transistor. Based on our achieved signal-to-noise ratio, we estimate that singlet-triplet single-shot readout with an average fidelity of 99.7% could be performed in 1 μs, well below the requirements for fault-tolerant readout and 30 times faster than without the Josephson parametric amplifier. Additionally, the Josephson parametric amplifier allows operation at a lower radio-frequency power while maintaining identical signal-to-noise ratio. We determine a noise temperature of 200 mK with a contribution from the Josephson parametric amplifier (25%), cryogenic amplifier (25%) and the resonator (50%), showing routes to further increase the readout speed.
Transmission and disease association of Kaposiʼs sarcoma-associated herpesvirus: recent developments (2004)

Evidence of Kaposi's sarcoma-associated herpesvirus transmission other than between homosexual adults and during childhood - namely transmission through heterosexual contact or injection drug use - is growing although these issues are still incompletely analysed and far away from being fully understood. Despite our increasing knowledge on transmission and disease associations of the virus, implications on the clinical management of associated diseases and public health have to be further evaluated in the coming years.
The idiotypic network—animal models and clinical implications (1997)

Journal Article The idiotypic network—animal models and clinical implications Get access Jacob George, Jacob George Department of Medicine ‘B’, and Research Unit of Autoimmune Diseases, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer 52621, Israel Search for other works by this author on: Oxford Academic Google Scholar Yair Levy, Yair Levy Department of Medicine ‘B’, and Research Unit of Autoimmune Diseases, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer 52621, Israel Search for other works by this author on: Oxford Academic Google Scholar Yehuda Shoenfeld Yehuda Shoenfeld Department of Medicine ‘B’, and Research Unit of Autoimmune Diseases, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer 52621, Israel Correspondence to: Yehuda Shoenfeld, Department of Medicine ‘B’, and Research Unit of Autoimmune Diseases, Tel-Hashomer and Sackler Faculty of Medicine, Tel-Aviv University, Sheba Medical Center, Tel-Hashomer 52621, Israel Search for other works by this author on: Oxford Academic Google Scholar Japanese Journal of Rheumatology, Volume 7, Issue 2, 1 June 1997, Pages 75–82, https://doi.org/10.3109/BF03041297 Published: 01 June 1997
The clinical effect of percutaneous kyphoplasty for the treatment of multiple osteoporotic vertebral compression fractures and the prevention of new vertebral fractures. (2015)

This study aimed to investigate the clinical effect of percutaneous kyphoplasty and the precautions against adjacent vertebral refractures in the treatment of multiple osteoporotic vertebral compression fractures. 54 cases (128 vertebrae) with multiple osteoporotic vertebral compression fractures from July 2007 to December 2013 treated with percutaneous kyphoplasty were retrospectively reviewed. 36 cases of them suffered from bi-segment vertebral fractures, 16 cases with tri-segment vertebral fractures and 2 cases with quadri-segment vertebral fractures. The operative effect was evaluated by visual analogue scale (VAS) score and oswestry disability index (ODI) score. Then the reasons for adjacent vertebral refractures were analyzed and the precautions were proposed. 54 cases (128 vertebrae) were admitted with percutaneous kyphoplasty successfully. No pulmonary embolism, spinal cord injury and other serious complications were found. The follow-up took 3-33 months with the average of 12 months. There was significant difference of VAS scores and ODI scores between pre-operation and post-operation (P<0.05). Bone cement leakage occurred in 23 vertebrae, and the incidence rate was 18.0%. 8 cases sustained adjacent vertebral refractures including 3 cases in the contiguous vertebral bodies and 5 cases in the interval vertebral bodies, and the incidence rate was 14.8%. 5 cases gained fracture healing after additional percutaneous kyphoplasty procedures while the other 3 cases were healed basically after conservative treatment for three months. In conclusion, percutaneous kyphoplasty is safe and effective to treat multiple osteoporotic vertebral compression fractures. However, the risk of new adjacent vertebral fractures in the multiple osteoporotic vertebral compression fractures is higher than that in the single osteoporotic vertebral compression fracture. Timely and proper treatment can reduce refractures.
Strong two-photon and three-photon absorptions in the antiparallel dimer of a porphyrin–phthalocyanine tandem (2010)

Imidazolyl-appended phthalocyaninatozinc(II) containing an ethynylporphyrin linkage was stacked by complementary coordination into an antiparallel dimer that displayed strong nonlinear optical properties involving two-photon and three-photon absorptions.
Removal of a Single Minor-Groove Functional Group Eliminates A-Tract Curvature (2006)

Much of the work in studying the phenomenon of A-tract curvature has involved the insertion of modified residues into the A-tract sequence and then cross-correlation of the structural differences with the resulting curvature effects. In the A-tract sequence d(A-T)5, removal of a single functional group (the O2-carbonyl of the central dT residue) by its replacement with hydrogen completely eliminates the curvature properties. This atom-specific change was accomplished by using the C-nucleoside dm32P in which the O2-carbonyl is replaced with -H but normal Watson-Crick hydrogen bonding is maintained. Similar derivatives with -F (dF62P) or -CH3 (dm62P) when present for the central dT residue also eliminate curvature. Finally, we have shown that the extent of curvature for sequences containing this carbonyl are sensitive to the [Mg2+], while those lacking the carbonyl show little to no Mg2+ dependence, strongly suggesting, we believe, a role for Na+/Mg2+ cooperative interactions in the minor groove to explain the curvature phenomenon.
Abstract TP323: The Relationships Among Hospital Volume, Processes of Care and Patient Outcome in Ischemic Stroke: J-ASPECT Study (2016)

Introduction: Higher hospital volumes have been related to better outcomes in previous researches. However, the mechanisms of the volume-outcome relationships in stroke have not been sufficiently figured out. The aim of this study is to uncover the roles of processes in acute phase stroke care among the volume-outcome relationships. Hypothesis: Processes of care mediate the volume-outcome relationships in stroke patients. Methods: We analyzed 45,598 acute ischemic stroke patients in 267 certified training hospitals in Japan. Data between April 1,2011 and May 31, 2012 was obtained from Japanese Diagnosis Procedure Combination Database. We divided annual hospital case volumes into two groups: high-volume and low-volume. Main outcome was 30-day mortality. We set following process of care as mediators: early initiation of aspirin prescription (less than 24 hours) and early initiation of stroke rehabilitation (less than 3 days). Multilevel mediation models were performed adjusting for age, gender, comorbidities, Charlson comorbidity index to examine the relationships among hospital volume, processes of care and outcome. Results: The early initiation of aspirin increased from 19.4% to 24.1%, the early initiation of rehabilitations increased from 59.6% to 65.6% and 30-day mortality decreased from 6.1% to 4.2%, for low-volume and high-volume hospitals. In the multilevel logistic regression analyses, admission to high-volume hospitals had 38% increased odds (OR = 1.38; 95% CI, 1.02-1.88) and 118% increased odds (OR = 2.18; 95% CI, 1.59-2.98) of early aspirin and rehabilitation initiation, compared with low-volume hospitals. Before adjusting for processes of care, admissions to high-volume hospitals had 30% decreased odds of death compared with admission to low-volume hospitals (OR = 0.70; 95% CI, 0.61-0.81). When processes of care were further adjusted, the volume-mortality relationship became non-significant. The early initiation of aspirin and rehabilitation accounted for 71% of the relationship (the regression coefficient was reduced from -0.355 to -0.102 when adjusted for processes of care). Conclusions: Processes of care mediated the volume-outcome relationships in stroke patients.
On getting away with it: On the experiences we don't have (2018)

In the psychoanalytic story people are ambivalent and transgressive, whatever else they are; and these predispositions raise, by implication, the issue of getting away with something, of avoiding what are deemed to be the inevitable consequences of certain actions. From a psychoanalytic point of view—in psychoanalytic language, as it were—analysts have to wonder not whether it would be possible not to feel guilty. But how is it possible, what would it sound like, not to be stifled by guilt? Getting away with it, as a wishful fantasy, is a way of imagining doing something to the super-ego that would make desire seems bearable, that would make pleasure seem pleasurable. The memories of getting away with it, in childhood and adolescence, are, more bluntly enigmatic. Getting away with it, in other words, is an experiment in privacy. It is, one might say, a conscious solitude with an unconscious backdrop.
Structure and Function of AIB1 (Amplified in Breast Cancer-1) Protein (2002)

Abstract : The overexpression or amplification of the AIB1 gene is observed in the majority of primary breast tumors, and is also correlated with a large percentage of hereditary and sporadic ovarian carcinomas. The AIB1 protein is a member of the steroid receptor coactivator family of transcriptional regulatory proteins that contain a conserved C-terminal histone acetyltransferase domain, and an N-terminal bHLH-PAS domain. The authors hypothesize that the HAT and bHLH-PAS domains of AIB1 play critical roles in mediating elevated transcriptional activation levels in AIB1-mediated cancers. The goal of this proposal is to determine the three-dimensional structure of the HAT and bHLH-PAS domains of AIB1 to facilitate the structure-based design of small molecule inhibitors to specifically target AIB1 for therapeutic application. To date, the authors have prepared several HAT and bHLH-PAS-containing AIB1 recombinants. Each of the HAT-containing domains, either alone or as GST fusion proteins, are unstable, suggesting that the HAT domain is not correctly folded and may require association with another protein factor for AIB1-mediated HAT activity. They have overexpressed and purified to homogeneity several N-terminal bHLH-PAS-containing domains that migrate as apparent monomers on gel filtration chromatography. Crystallization efforts to these bHLH-PAS-containing AIB1 domains are underway to facilitate an X-ray crystal structure determination. (15 refs.)
Privacy- and integrity-preserving range query in wireless sensor networks (2012)

A large-scale wireless sensor network constructed in terms of two-tiered architecture, where cloud nodes take charge of storing sensed data and processing queries with respect to the sensing nodes and querists, incurs security breach. This is because the importance of cloud nodes makes them attractive to adversaries and raises concerns about data privacy and query result correctness. To address these problems, we propose an efficient approach, namely EQ (efficient query), which mainly prevents adversaries from gaining the information processed by or stored in cloud nodes, and detects the compromised cloud nodes when they misbehave. EQ can not only achieve the goals of data privacy and integrity preserving but also ensure the secure range query without incurring false positive. For data privacy preserving, EQ presents an order encryption mechanism by adopting stream cipher to encrypt/decrypt all sensed data such that a cloud node can only process issued queries over stored data in the encryption domain. For data integrity/completeness, we manipulate a data structure of XOR linked list (X2L), which allows a querist to verify the integrity of retrieved data via the socalled verification information, i.e., neighborhood difference in a storage-efficient manner. We demonstrate the feasibility and efficiency of EQ via experiments conducted on TelosB prototype sensor platform running TinyOS 1.1.15 and comparisons with state-of-the-arts.
Algorithms and Applications for Community Detection in Weighted Networks (2014)

Community detection is an important issue due to its wide use in designing network protocols such as data forwarding in Delay Tolerant Networks (DTN) and worm containment in Online Social Networks (OSN). However, most of the existing community detection algorithms focus on binary networks. Since most networks are naturally weighted such as DTN or OSN, in this article, we address the problems of community detection in weighted networks, exploit community for data forwarding in DTN and worm containment in OSN, and demonstrate how community can facilitate these network designs. Specifically, we propose a novel community detection algorithm, and introduce two metrics: intra-centrality and inter-centrality, to characterize nodes in communities, based on which we propose an efficient data forwarding algorithm for DTN and a worm containment strategy for OSN. Extensive trace-driven simulation results show that the proposed community detection algorithm, the data forwarding algorithm, and the worm containment strategy significantly outperform existing works.
Abstract 18410: Gastrointestinal Bleeding in Recipients of the HeartWare Ventricular Assist System (2013)

Purpose: Gastrointestinal bleeding (GIB) is a significant problem with continuous flow left ventricular assist devices. The HeartWare HVAD was recently approved for bridge to transplantation (BTT). GIB in patients supported with the HVAD as part of the pivotal BTT trial and the Continued Access Protocol (CAP) is reviewed. Methods: GIB events from 332 HeartWare recipients (140 BTT, 192 CAP patients) having at least 6 months of follow up (306 patient-years) were analyzed. Post implant anticoagulation consisted of heparin followed by Coumadin at a target INR of 2-3. Aspirin was recommended at 81-325 mg. Statistical analysis was performed using Fisher’s exact test for the comparison of proportions and Poisson regression for the comparison of event rates. Results: Forty-two (12.7%) patients (78.6% men) age 55.3 ± 11.4 yrs experienced a GIB. Overall, the 42 patients had 82 GIB events that resulted in 0.27 events PPY (range 1-7 events) with 38% experiencing a recurrent GIB. Median time to first GIB was 89 days. GIB was more frequent in patients receiving 81mg aspirin vs. 325mg (0.14 vs. 0.09 PPY, P=0.018). Patients with GIB were more likely to have ischemic CHF etiology (54.8% vs. 34.1% P =0.016), and diabetes (47.6% vs. 33.1%, P=0.083). Most GIB events (71/82, 86.6%) occurred &gt;30 days post implant and 94% required transfusions. Seventeen percent of events occurred in setting of INR &gt;3. GIB resulted in 65 rehospitalizations in 32 patients with a median length of stay of 8 days. Source of bleeding was ascribed to a definite or suspected AVM in 28% of patients while in 29% of patients, no source was identified. Location was 22% upper GI, 32% small bowel, 11% lower GI and 33% unknown. Forty-six percent of patients with GIB had an intervention such as cautery or clipping. None required surgery. There were no deaths related to GIB. Conclusion: GIB occurred in 12.7% of HVAD recipients followed for at least 6 months postop. GIB events were often recurrent, led to transfusions and were rarely associated with supratherapeutic INRs. Most occurred outside the perioperative window and AVMs were the predominant culprit lesion. Rehospitalizations were frequent and prolonged. Efforts to reduce the incidence of and readmissions for GIB are warranted.
&amp;quot;Combined Diagnostic Tool&amp;quot; APPlication to a Retrospective Series of Patients Undergoing Total Joint Revision Surgery (2017)

<b>Background</b>: Differentiating between septic and aseptic joint prosthesis may be challenging, since no single test is able to confirm or rule out infection. The choice and interpretation of the panel of tests performed in any case often relies on empirical evaluation and poorly validated scores. The "Combined Diagnostic Tool (CDT)" App, a smartphone application for iOS, was developed to allow to automatically calculate the probability of having a of periprosthetic joint infection, on the basis of the relative sensitivity and specificity of the positive and negative diagnostic tests performed in any given patient. <b>Objective</b>: The aim of the present study was to apply the CDT software to investigate the ability of the tests routinely performed in three high-volume European centers to diagnose a periprosthetic infection. <b>Methods</b>: This three-center retrospective study included 120 consecutive patients undergoing total hip or knee revision, and included 65 infected patients (Group A) and 55 patients without infection (Group B). The following parameters were evaluated: number and type of positive and negative diagnostic tests performed pre-, intra- and post-operatively and resultant probability calculated by the CDT App of having a peri-prosthetic joint infection, based on pre-, intra- and post-operative combined tests. <b>Results</b>: Serological tests were the most common performed, with an average 2.7 tests per patient for Group A and 2.2 for Group B, followed by joint aspiration (0.9 and 0.8 tests per patient, respectively) and imaging techniques (0.5 and 0.2 test per patient). Mean CDT App calculated probability of having an infection based on pre-operative tests was 79.4% for patients in Group A and 35.7 in Group B. Twenty-nine patients in Group A had > 10% chance of not having an infection, and 29 of Group B had > 10% chance of having an infection. <b>Conclusion</b>: This is the first retrospective study focused on investigating the number and type of tests commonly performed prior to joint revision surgery and aimed at evaluating their combined ability to diagnose a peri-prosthetic infection. CDT App allowed us to demonstrate that, on average, the routine combination of commonly used tests is unable to diagnose pre-operatively a peri-prosthetic infection with a probability higher than 90%.
Transient Kinetic Studies Support Refinements to the Chemical and Kinetic Mechanisms of Aminolevulinate Synthase (2007)

5-Aminolevulinate synthase catalyzes the pyridoxal 5'-phosphate-dependent condensation of glycine and succinyl-CoA to produce carbon dioxide, CoA, and 5-aminolevulinate, in a reaction cycle involving the mechanistically unusual successive cleavage of two amino acid substrate alpha-carbon bonds. Single and multiple turnover rapid scanning stopped-flow experiments have been conducted from pH 6.8-9.2 and 5-35 degrees C, and the results, interpreted within the framework of the recently solved crystal structures, allow refined characterization of the central kinetic and chemical steps of the reaction cycle. Quinonoid intermediate formation occurs with an apparent pK(a) of 7.7 +/- 0.1, which is assigned to His-207 acid-catalyzed decarboxylation of the alpha-amino-beta-ketoadipate intermediate to form an enol that is in rapid equilibrium with the 5-aminolevulinate-bound quinonoid species. Quinonoid intermediate decay occurs in two kinetic steps, the first of which is acid-catalyzed with a pK(a) of 8.1 +/- 0.1, and is assigned to protonation of the enol by Lys-313 to generate the product-bound external aldimine. The second step of quinonoid decay defines k(cat) and is relatively pH-independent and is assigned to opening of the active site loop to allow ALA dissociation. The data support important refinements to both the chemical and kinetic mechanisms and indicate that 5-aminolevulinate synthase operates under the stereoelectronic control predicted by Dunathan's hypothesis.
Vanadium Salts in the Treatment of Human Diabetes Mellitus (1998)

Oral insulinmimetic properties and safety of sodium metavanadate (NaVO3) in human IDDM and NIDDM, and vanadyl sulfate (VOSO4) in NIDDM are reviewed and new studies are presented. In a single blind placebo lead in trial with VOSO4, glucose metabolism in a two-step euglycemic insulin clamp did not increase in any of three subjects (age 57.7±0.9 yrs; M/F 1/2; BMI 39±10 kg/m2; HbA1 10.7±1.3%) after 6 weeks vanadyl therapy dosed at 25 mg V daily. However, insulin sensitivity improved in 3 of 5 subjects (age 56.2±6.0 yrs; M/F 5/0; BMI 31.9±5.4 kg/m2; HbA1 10.7±2.1%) when dosed at 50 mg V daily, from 30-83% and 9-230% at 0.5 and 1.0 mU/kg insulin, respectively; and insulin sensitivity improved in 3 of 5 subjects (age 52.0±8.6 yrs; M/F 3/2; BMI 39.0±7.8 kg/m2; HbA1 6.9±1.0%) when dosed at 100 mg V daily, from 47-775% and 16-75% at 0.5 and 1.0 mU/kg insulin, respectively. Basal hepatic glucose production (HGP) and suppression of HGP by insulin were unchanged at both doses. There was no change in fasting blood glucose, glycohemoglobin, or mean systolic, diastolic, mean arterial blood pressures or in mean heart rates on 24 hr ambulatory monitors. Peak serum V levels for the 25 and 50 mg V dose were 15.7±3.7 and 79.1±24.0 ng/ml, respectively. 50 and 100 mg V doses caused some gastrointestinal intolerance, without biochemical evidence of toxicity. V is well tolerated for six weeks, but at these doses do not dramatically improve insulin sensitivity or glycemic control in all individuals.