gebhart/patrepeval huggingface dataset:
ANALYSIS OF REJECTION AND ATN AFTER INDUCTION WITH ATG, BASILIXIMAB AND DACLIZIMAB IN CADAVERIC KIDNEY TRANSPLANT RECIPIENTS (1999)

14 Basiliximab (Simulect) and daclizumab (Zenapax) are monoclonal antibody therapies directed against the alpha subunit of the IL-2 receptor. Although basiliximab and daclizumab have similar mechanisms of action, daclizumab requires 5 doses compared to 2 doses of basiliximab. The cost per dose of basiliximab and daclizumab are comparable ($1224 and $1254 respectively). We examined the recent use of basiliximab and daclizumab in our center and compared the results to ATG (ATGAM) induction in cadaveric renal allografts. 106 patients were treated with ATG from 1/92 to 3/98. 69 patients were induced with basiliximab from 12/97 to 12/98. 37 recipients were induced with daclizumab from 7/97 to 7/98. Maintenance immunosuppression consisting of prednisone, mycophenolate mofetil or azathioprine and cyclosporine or FK506 was used in all patients. Demographics such as recipient age, sex and race were comparable in each treatment group. Rejection and ATN rates are depicted below. (Table)TableExamination of early allograft rejection (1 - 2 months post-transplant) showed the highest rate of rejection among those patients treated with daclizumab while similar early rejection rates were seen in those patients treated with basiliximab and ATG. Late allograft rejection rates (3-4 months post-transplant) were not significantly different in patients treated with basiliximab and daclizumab (p=0.65) and higher than ATG recipients. Rates of post-transplant ATN (as defined by the need for hemodialysis post-transplant) were not statistically different between treatment groups. However, when rejection rates in recipients with post-transplant ATN were examined, recipients induced with ATG had less rejection than those treated with either basiliximab or daclizumab (p=0.06). Lack of a statistically significant difference in rejection with ATN could be attributed to the small number in each treatment group. The total cost of treatment with Zenapax ($6270) was greater than that of a course of Simulect ($2448). Given the similar rejection rates for Simulect and Zenapax at 120 days post-transplant, Simulect appears to be the more economic choice. While ATG is more expensive than both Simulect and Zenapax, patients with post-transplant ATN induced with ATG had a lower incidence of rejection.
Comparison of commercial European wheat cultivars to <i>Fusarium</i> infection of head and seedling tissue (2006)

Susceptibility of eight commercial European wheat cultivars to fusarium head blight (FHB) disease caused by Fusarium graminearum , F. culmorum , F. poae and Microdochium nivale (formerly known as Fusarium nivale ) was compared under controlled environment conditions (16°C). FHB did not differentially affect cultivars in terms of disease symptoms, fungal DNA content of grain or deoxynivalenol (DON) contamination. However, the Hungarian‐grown cultivars GK‐Othalom and Fatima 2 (of Romanian origin) showed greater type V resistance (yield tolerance) to FHB than did the others. Also, nivalenol was produced by F. poae in these two cultivars and in Italian cultivar Norba, but not in other cultivars. Overall, significant relationships were found between the FHB and seedling blight resistance in vitro of these eight cultivars, but such relationships were generally highly dependent on cultivar, and therefore it is likely that the in vitro test is at best measuring components of FHB resistance and/or genotype‐specific resistance components.
Novel Front-End Pulse Processing Scheme for PET System Based on Pulse Width Modulation and Pulse Train Method (2010)

The architecture of a multi-channel front-end system is important for realizing a high-resolution PET system. We propose a novel front-end pulse processing scheme with pulse width modulation (PWM) and pulse train method for PET systems. Each channel of the proposed system consists of a preamplifier, a shaping amplifier, a comparator, and a digital circuit that generates a pulse train for each event. The preamplifier-shaper-discriminator module first generates a trigger pulse with time-over-threshold (ToT), which contains the energy information. The trigger pulse is then processed through a digital circuit that adds subsequent pulses to form a pulse train. These additional pulses encode channel information, timing information, etc. The digital signal output of each channel can be connected by simple wired-OR logic, and the output is read in one transmission line. This multi-channel, low power consumption front-end scheme can acquire enough pulse height (energy) and position information to realize a PET system with a significantly smaller number of output pins in the front-end ASIC. The pulse width encoding also simplifies the digital processing system. We designed a new ASIC based on this concept. The proposed architecture can be applied to high-resolution PET systems with multi-channel ASICs.
Differences in Ischemic Threshold and Nitrate Efficacy between Normotensive and Hypertensive Patients with Stable Angina Pectoris. (1995)

The coexistence of ischemic heart disease with hypertension makes antihypertensive therapy essential, since relief of hypertension may ameliorate the coronary disease. On the other hand, the effect of antianginal nitrate therapy in patients with stable angina pectoris and systemic arterial hypertension is not fully understood. This study assessed the effects of hypertension on the ischemic threshold and the time to moderate angina, measured as parameters of nitrate efficacy. In this double-blind, parallel-group study, 141 patients with stable angina pectoris were randomly assigned to receive 5 mg, 10 mg or 20 mg isosorbide-5-mononitrate or matching placebo bid for 21 days. Ninety-three normotensive and 48 hypertensive patients were compared with regard to the time to moderate anginal pain and the ischemic threshold before and after nitrate treatment on the first day of the study. The acute nitrate effect 2 h after drug administration was substantially attenuated in hypertensives at both 10 and 20 mg of isosorbide-5-mononitrate, with the time to moderate anginal pain being significantly shortened. Impaired vasodilatator response of the arterial vasculature to organic nitrates, probably due to impaired biotransformation of organic nitrates to nitric oxide in hypertensive patients, is suggested as a possible mechanism for the diminished nitrate effect. Thus, oral nitrate therapy does not have the same beneficial antianginal effect in hypertensive patients as it does in normotensives. Dose adjustment based on the pretreatment blood pressure, and the administration of higher doses of oral nitrates should therefore be considered in hypertensive patients suffering from stable angina pectoris.
Angular Dependence of Scattering of Ultrasound from Blood (1977)

The angular scattering of 5-MHz ultrasonic waves by blood was measured in the range from 60 to 1500. Experimental and theoretical results agree very well. A discussion on the use of angular scattering for determining the mechanical properties of the erythrocyte is presented.
Congenital canine myasthenia gravis: I. Deficient junctional acetylcholine receptors (1984)

The neuromuscular junction was studied during growth in two breeds of dog with a congenital familial form of myasthenia gravis (CMG): the Jack Russell terrier and the springer spaniel. Light microscopy revealed no difference in endplate size or nerve terminal morphology in age-matched CMG dogs and unaffected littermates. At all ages there was in individual muscle fibers of CMG dogs an approximately 75% lower postsynaptic membrane density of acetylcholine receptors (AChR). There was no evidence that this abnormality had an autoimmune basis. Measurements of miniature endplate potential amplitude in relation to fiber diameter revealed that the low density of AChR in the postsynaptic membrane of CMG dogs remained constant and did not change with the marked progression of muscle weakness during growth. Antigenic determinants of AChR were deficient in CMG muscle to the same extent as alpha-bungarotoxin (alpha BT) binding sites. Thus, a low density of AChR in the muscle's postsynaptic membrane appears to be the principal abnormality of CMG. The data suggest that the normal increase in number of acetylcholine (ACh) quanta released by nerve impulse may not fully compensate for the reduction in depolarization produced by a single quantum as the muscle fiber diameter increases. This could cause progression of weakness during growth. In addition to being a useful animal model of a rare form of CMG that resembles one form of human CMG, canine CMG offers a unique model for investigating events of synaptogenesis at the neuromuscular junction.
Recruitment Kinetics of DNA Repair Proteins Mdc1 and Rad52 but Not 53BP1 Depend on Damage Complexity (2012)

The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-induced foci was studied by live-cell fluorescence microscopy after ion microirradiation. To investigate the influence of damage density and complexity on recruitment kinetics, which cannot be done by UV laser irradiation used in former studies, we utilized 43 MeV carbon ions with high linear energy transfer per ion (LET = 370 keV/µm) to create a large fraction of clustered DSBs, thus forming complex DNA damage, and 20 MeV protons with low LET (LET = 2.6 keV/µm) to create mainly isolated DSBs. Kinetics for all three proteins was characterized by a time lag period T(0) after irradiation, during which no foci are formed. Subsequently, the proteins accumulate into foci with characteristic mean recruitment times τ(1). Mdc1 accumulates faster (T(0) = 17 ± 2 s, τ(1) = 98 ± 11 s) than 53BP1 (T(0) = 77 ± 7 s, τ(1) = 310 ± 60 s) after high LET irradiation. However, recruitment of Mdc1 slows down (T(0) = 73 ± 16 s, τ(1) = 1050 ± 270 s) after low LET irradiation. The recruitment kinetics of Rad52 is slower than that of Mdc1, but exhibits the same dependence on LET. In contrast, the mean recruitment time τ(1) of 53BP1 remains almost constant when varying LET. Comparison to literature data on Mdc1 recruitment after UV laser irradiation shows that this rather resembles recruitment after high than low LET ionizing radiation. So this work shows that damage quality has a large influence on repair processes and has to be considered when comparing different studies.
Using Levels of Detail to Speedup Radiosity Computation (1999)

Clustering and partitioning based methods have improved drastically Hierarchic- al Radiosity (HR). The first method reduces the number of links but lacks precision since it does not account precisely for the orientations of the patches, within the emitting and receiving clusters, during the illuminati- on calculation. As for the second approach, it is efficient since it partition- s large environments into 3D cells and emploies ordering strategies that need only a subset of cells for computing illumination at each step of the resolution process. Nevertheless, the computation complexity still remains high when the cells contain many objects of highly detailed geometry. The new HR, described in this paper, brings solutions to these problems by making use of Levels Of Details (LOD) that approximate the geometry of the object surfaces in the scene.
A Nanofiber-based Memory for Light (2015)

Developing light-matter interfaces is a crucial capability with unique applications to quantum optics and quantum information networks. In this context, our group focuses on the development of quantum memories in cold, neutral atom clouds, using both electromagnetically-induced transparency (EIT) and DLCZ as interacting schemes [1]. We recently reported for instance the quantum storage of qubits encoded in the orbital angular momentum degree of freedom [2]. Here, we demonstrate [3] for the first time EIT and optical storage at the single-photon level for the light tightly guided by a subwavelength-diameter optical fiber, aka nanofiber. In a nanofiber, the guided photons are highly confined and the majority of the light power travels in the evanescent field outside the glass. This new setting is a promising alternative to free-space focusing, which limits the interaction one can obtain, and provides a novel platform for developing all-fibered quantum networks.
Regulating billions of blood platelets: glycans and beyond (2015)

The human body produces and removes 10(11) platelets daily to maintain a normal steady state platelet count. Platelet production must be regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. Multifaceted and complex mechanisms control platelet production and removal in physiological and pathological conditions. This review will focus on different mechanisms of platelet senescence and clearance with specific emphasis on the role of posttranslational modifications. It will also briefly address platelet transfusion and the role of glycans in the clearance of stored platelets.
iSeSA (2022)

High Performance Computing applications typically involve compute intensive simulations which inherently may process large amounts of data at high speeds. The high compute requirements of these applications often exceed the on-premise cluster capacity to analyze the research data. Furthermore, capacity planning becomes very challenging for dynamically varying workloads due to their frequently changing resource demands. These challenges can be mitigated using highly scalable and cost-effective cloud services such as serverless platforms.
On the Influence of Dispersoids on the Particle Stimulated Nucleation of Recrystallization in an Al-Fe-Si Model Alloy (1997)

The recrystallization of Al-alloys is controlled by precipitates. Whereas large particles generally promote recrystallization by particle stimulated nucleation, finely dispersed precipitates - either already present in the as-deformed state or precipitating during the recrystallization anneal - are known to strongly retard recrystallization. It was the aim of the present study to elucidate these concurring effects of large particles and small dispersoids on recrystallization in a ternary Al-Fe-Si model alloy. For that purpose, samples were prepared according to different pre-annealing treatments so as to comprise different states of precipitation and supersaturation. The evolution of microstructure and texture during rolling and recrystallization was characterized by metallography and by conventional X-ray texture analysis. EBSD-local texture investigations were employed to yield information on the efficiency of nucleation at the various nucleation sites and, consequently, on the influence of dispersoids on recrystallization.
Methylcellulose 조성 온도 감응성 졸-젤 유착방지제 (2017)

유착방지막을 제조하기 위해 methylcellulose(MC)와 xanthan gum(XT) 조성의 온도 감응성 졸-젤을 제조하였다. MC/XT 졸(sol)은 사람의 신체온도(37 ℃)에서 1분 안에 젤화(gelation)가 일어나는 것을 보였다. Rat에 온도 감응성 졸-젤을 주입하여 생체적합성 및 생체분해성을 확인하였다. 또한 온도 감응성 졸-젤이 장기 및 조직의 유착방지에 효과가 높은 것을 관찰하였다. 그 결과 MC/XT 졸-젤은 조직 유착방지막의 좋은 후보 물질임을 확인하였다.
IPv6 Subnet Model (2008)

RFC 4861 [ND] describes host data forwarding and address resolution.
However, nine years after the ND protocol became an RFC, IPv6 hosts
still do not fully comply with RFC 4861 [ND]. In particular, hosts
incorrectly implement on- vs. off-link data forwarding. This document
clarifies host behavior and associated router behavior to define
explicitly on-link and off-link determination.
An embedded wavelet video coder using three-dimensional set partitioning in hierarchical trees (SPIHT) (2002)

The SPIHT (set partitioning in hierarchical trees) algorithm by Said and Pearlman (see IEEE Trans. on Circuits and Systems for Video Technology, no.6, p.243-250, 1996) is known to have produced some of the best results in still image coding. It is a fully embedded wavelet coding algorithm with precise rate control and low complexity. We present an application of the SPIHT algorithm to video sequences, using three-dimensional (3D) wavelet decompositions and 3D spatio-temporal dependence trees. A full 3D-SPIHT encoder/decoder is implemented in software and is compared against MPEG-2 in parallel simulations. Although there is no motion estimation or compensation in the 3D SPIHT, it performs measurably and visually better than MPEG-2, which employs complicated motion estimation and compensation.
Modelling and Imaging Through a Gas-Obscured Zone in Malaysia (2014)

Description of the material The study area is situated SB311 block of Malaysia. The tectonic evolution of the area is linked to the rifting of South China Sea. The image of the target in this study is affected by the shallow gas-obscured zone in the overburden. The goal of this study is to investigate new acquisition techniques and parameters capable of imaging through the gas-obscured zones, using advanced modeling and imaging technologies. Application Based on regional geology and seismic data, two sets of models containing "geobodies" filled or partially filled with gas were built. The geobodies were constructed based on the characters of seismic amplitudes and stratigraphy, and they were distributed above and below the top of KBB formation. P-wave velocities (Vp), S-wave velocities (Vs) and bulk densities (ρ) inside geobodies were modified based on Biot-Gassmann fluid substitution and the Xu-White Differential Effective Medium (DEM) method. A 15m thick of unconsolidated low velocity materials was added to model immediately beneath the water bottom to investigate the feasibility of P-to-S converted wave recording. Results, Observations, and Conclusions Acoustic modeling and RTM imaging have suggested that long offset (&amp;gt;10 km) is required in order for undershooting. Any newly acquired long-offset 2D streamer data could not only have potential for imaging the base of KBB, but also assist reprocessing of existing 3D seismic data. Elastic modeling followed by dual-velocity RTM has suggested that P-to-S converted waves have potential for imaging both top and base of the Kebabangan reservoir, even with the 15m thick of low velocity layer below the water bottom. This assumes that vector fidelity and coupling of the phones or nodes at the ocean bottom can be secured. Significance of Subject Matter With the recent advances of ocean bottom nodes (OBN) technologies, converted wave survey may have potential to solve for the obscured-zone imaging problems in Malaysia and other regions around the world. Acknowledgement We thank Robert Beham of Malaysia Business Unit and Brad Bankhead of Geophysical Technology at ConocoPhillips for supporting this project.
Shear Dielectric and Rheological Responses of Polymeric Flows (2003)

A variation of dielectric properties with deformation is typically not seen in viscous liquids. However, the dielectrostriction effect can be observed in viscoelastic liquids such as polymers. The dielectrostriction effect resembles a well-known birefringence phenomenon. While birefringence in liquid polymers is described by the stress-optical rule, the stress-dielectric rule works for dielectrostriction. In this article, experimental evidences of the dielectrostriction effect in liquid polymers are presented for the first time. Dielectric and rheological measurements of liquid silicone elastomers having different degree of cross-linking are conducted at different frequencies and amplitudes of oscillatory shear flow. A stress-dielectric relationship exists between shear dielectrostriction response and storage modulus which is similar to stress-optical rule.
2021 Longdom Announcement International Conference on Pharmacology andToxicology March 15-16, 2021 | Osaka, Japan (2021)

The theme for the Pharmacology Congress2021 is “Emerging trends in pharmacology.”Longdom conferences extends our immense pleasure and honor to invite you to attend “Pharmacology congress 2021”
Pharmacology  is the branch of the biology involved with the study of drug action wherever a drug will be loosely outlined as any artificial, natural or endogenous molecule that exerts organic chemistry or physiological impact on the cell, tissue, organ or organism. A lot of specifically, it's the study of the interactions that occur between a living organism and chemicals that have an effect on traditional or abnormal organic chemistry operates. If substances have healthful properties, they're thought-about prescription drugs
Photopatterned Membranes and Chemical Gradients Enable Scalable Phenotypic Organization of Primary Human Colon Epithelial Models (2019)

Biochemical gradients across the intestinal epithelium play a major role in governing intestinal stem cell compartmentalization, differentiation dynamics, and organ-level self-renewal. However, scalable platforms that recapitulate the architecture and gradients present in vivo are absent. We present a platform in which individually addressable arrays of chemical gradients along the intestinal crypt long axis can be generated, enabling scalable culture of primary in vitro colonic epithelial replicas. The platform utilizes standardized well plate spacing, maintains access to basal and luminal compartments, and relies on a photopatterned porous membrane to act as diffusion windows while supporting the in vitro crypts. Simultaneous fabrication of 3875 crypts over a single membrane was developed. Growth factor gradients were modeled and then experimentally optimized to promote long-term health and self-renewal of the crypts which were assayed in situ by confocal fluorescence microscopy. The cultured in vitro crypt arrays successfully recapitulated the architecture and luminal-to-basal phenotypic polarity observed in vivo. Furthermore, known signaling regulators (e.g., butyrate and DAPT) produced measurable and predictable effects on the organized cell compartments, each decreasing crypt proliferation in the basal regions to negligible values. This platform is readily adaptable to the screening of tissue from individual patients to assay the impact of food and bacterial metabolites and/or drugs on colonic crypt dynamics. Importantly, the cassette is compatible with a wide range of sensing/detection modalities, and the developed fabrication methods should find applications for other cell and tissue types.