gebhart/patrepeval huggingface dataset:
Abstract TP334: A Novel Murine Model of the Effects of Helicopter Emergency Medical Services Transportation on Ischemia and Thrombolysis (2019)

Background: Helicopter emergent medical services (HEMS) transportation is critical for rapid transportation of patients for mechanical thrombectomy and rtPA-mediated reperfusion. However, the effect of the multiple unique physical factors present in HEMS on the outcomes of these procedures is not known. Experimental models of ischemia-reperfusion that replicate HEMS conditions are needed in order to address this issue before putative neuroprotective therapies during flight trials can be accurately evaluated. Methods: A novel experimental model of “drip &amp; ship” during HEMS was developed using middle cerebral artery occlusion (MCAO) with autologous clot in mice and an Mi2 helicopter adapted for animal research. Since vibration is one of the most salient physical components in HEMS, we isolated this factor for mechanistic investigation. The vibratory signature during HEMS was recorded in-flight using accelerometers and then recapitulated in a six-degree-of-freedom man-rated Moog-FCS motion platform in the laboratory. We evaluated two approaches (simultaneous vs. sequential) to expose mice with MCAO to the three different settings (helicopter/simulator/ground) in order to find the most optimal methodologically. Results: A clot length of 30 mm and 90 min of rTPA initiation post MCAO achieved significant infarctions while minimizing periprocedural mortality. Two MCAOs were the maximum capable of achieving occlusion times &lt;15 minutes apart. In order to maintain MCAO to rtPA times close to 90 minutes, a sequential exposure to the three settings (helicopter/simulator/ground) was established with 2 mice each. Randomly assigned exposure lasted for 1 h and occurred at the same time of the rtPA exposure. The three exposures were 2 hours apart to minimize the effect of atmospheric variations. The animal MRI facility was coordinated to acutely scan the animals after the three exposures. Conclusion: We have developed an animal model to study the effects of HEMS on rtPA/reperfusion. An ongoing experiment measuring infarction volume and clinical outcomes will determine the need to maintain an actual HEMS for future experiments, or whether a laboratory simulator will suffice.
AI &amp; Public Data for Humanitarian and Emergency Response (2022)

When an emergency event, or an incident relevant for peacekeeping or humanitarian needs first occurs, getting the right information as quickly as possible is critical in saving lives. When an event is ongoing, information on what is happening can be critical in making decisions to keep people safe and take control of the particular situation unfolding. In both cases, first responders, peacekeepers, and others have to quickly make decisions that include what resources to deploy and where. Fortunately, in most emergencies, people use social media to publicly share information. At the same time, sensor data is increasingly becoming available. But a platform to detect emergency situations and deliver the right information has to deal with ingesting thousands of noisy data points per second: sifting through and identifying relevant information, from different sources, in different formats, with varying levels of detail, in real time, so that relevant individuals and teams can be alerted at the right level and at the right time. In this talk I will describe the technical challenges in processing vast amounts of heterogenous, noisy data in real time from the web and other sources, highlighting the importance of interdisciplinary research and a human-centered approach to address problems in humanitarian and emergency response. I will give specific examples and discuss relevant future research directions in Machine Learning, NLP, Information Retrieval, Computer Vision and other fields, highlighting the role of knowledge combined with Neural and other approaches. This talk will present an overview, and draw from some of our publications at CVPR, AAAI, EMNLP, and others.
High dynamic range fiber optic relative humidity sensor (2002)

We present a fiber optic relative humidity sensor. The sensor was fabricated by coating a thin polyvinyl alcohol/CoCl 2 film on a 200-μm core plastic-cladding fiber; the film was deposited after removing the cladding of the fiber. It was found that bending the fiber leads to drastic changes in the response behavior. The sensor was compared against a commercially available relative humidity sensor and was found to be sensitive to relative humidity ranging from 3 to 90%. The sensor response is usually very fast, but varies at different humidity levels and has a good dynamical range. The sensor response is repeatable and fully reversible, and should be useful for monitoring relative humidity in harsh industrial environments.
Comparing Multiagent Systems Research in Combinatorial Auctions and Voting. (2008)

In a combinatorial auction, a set of items is for sale, and agents can bid on subsets of these items. In a voting setting, the agents decide among a set of alternatives by having each agent rank all the alternatives. Many of the key research issues in these two domains are similar. The aim of this paper is to give a convenient side-by-side comparison that will clarify the relation between the domains, and serve as a guide to future research. 1
Propene bulk polymerization kinetics: Role of prepolymerization and hydrogen (2003)

Abstract An experimental setup for the polymerization of liquid propylene was used to carry out main polymerizations with and without a prepolymerization step. Two types of prepolymerization are introduced: at a constant temperature and at rapidly increasing reactor temperatures. With the present catalyst system, at high polymerization temperatures, a prepolymerization step will increase polymerization rate. Hydrogen was used to control the molecular weight of the product. The polymerization reactor was used in combination with a gas chromatograph to determine the vapor‐liquid equilibrium (VLE) of the propylene‐hydrogen system. Measurements are compared to predictions of different equations of state. The Peng‐Robinson equation of state is best able to describe the VLE for this binary system. A temperature‐dependent interaction parameter was derived from the fits to the measured data.
Coherent wired/wireless seamless transmission with combination of photonic digital and analogue techniques (2012)

Digital coherent detection and radio-over-fiber technologies allow the realization of direct seamless conversion between optical and radio networks. We propose a photonic dig- ital transmission with analogue signal synthesis technique to provide high-speed simultaneous transmissions.
Application of shear wave imaging and shear wave dispersion ultrasound vibrometry in assessing viscoelastic properties of human thyroid: <i>In vivo</i> pilot study (2013)

Thyroid cancer is the fastest growing age and gender adjusted cancer in 2011 according the American Cancer Society. The majority of the clinically diagnosed thyroid nodules are benign while less than 5% represent intrathyroidal cancers. Currently, the clinical gold-standard procedure for assessing the thyroid nodules is needle biopsy, a procedure that is associated with significant financial burden as well as pain and risk for patients. Therefore, a noninvasive, affordable, and potentially widely available method to differentiate between benign and malignant thyroid nodules can play an important role in reducing the number of unnecessary biopsies. In this study, we investigate the feasibility of two acoustic radiation force elastography techniques, shear wave dispersion ultrasound vibrometry (SDUV) and comb-push ultrasound shear wave elastography (CUSE imaging), in identifying thyroid nodules (imaging) and differentiating between benign and malignant pathologies based on their elasticity and viscosity (SDUV measurements). Our preliminary results show that the measured shear elasticity and shear viscosity parameters depend on tissue type; hence, these measurements may be utilized to differentiate between healthy normal thyroid tissue, benign nodules, and malignant nodules. Further studies on a large population of patients is required to better evaluate the role of the combination of elasticity and viscosity properties of tissue in differentiating various thyroid nodules.
BioGeoChemical product provided by the Copernicus Marine Service (2021)

&amp;lt;p&amp;gt;&amp;lt;span&amp;gt;We present the in-situ biogeochemical data products distributed by the Copernicus Marine Service since 2018. The products offer available data of chlorophyll, oxygen, and nutrients (nitrate, silicate and phosphate), both in near-real time and as re-processed data, collected across the globe. The re-processing involves careful quality control utilizing tailored automated quality control procedures combined with visual inspection of questionable values by experts. Moreover, oxygen data are provided with uniform units for modelers (&amp;amp;#181;mol/l) and other oceanic applications and monitoring purposes (&amp;amp;#181;mol/kg) &amp;lt;/span&amp;gt;&amp;lt;span&amp;gt;The products integrate observations aggregated from the Regional EuroGOOS consortium, as well as from SeaDataNet2, National Data Centers (NODCs) and JCOMM global systems, among others.&amp;lt;/span&amp;gt;&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;W&amp;lt;span&amp;gt;e highlight some use cases, including a study showing an overall decline in the nutrient concentration (nitrate and silicate) of the Atlantic Water flowing though the Nordic Seas en-route to the Arctic Ocean, during the period 1990-2019. Moreover, the study shows indications of a delayed-response reduction further downstream in the Arctic Water exiting the Arctic Ocean through Fram Strait. Other use cases include the study of variability in the concentration of dissolved oxygen in the Mediterranean Sea, showing an association with dynamical processes.&amp;lt;/span&amp;gt;&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;&amp;lt;span&amp;gt;The in-situ near-real time biogeochemical product is updated every month whereas the re-processed product is updated two times per year. Products are delivered &amp;lt;/span&amp;gt;&amp;lt;span&amp;gt;on NetCDF4 format compliant with the CF1.7 standard and well-documented quality control procedures.&amp;lt;/span&amp;gt;&amp;lt;/p&amp;gt;
Epitaxial graphene on SiC: 2D sheets, selective growth and nanoribbons (2016)

Epitaxial graphene grown on SiC by the confinement controlled sublimation method is reviewed, with an emphasis on multilayer and monolayer epitaxial graphene on the carbon face of 4H-SiC and on directed and selectively grown structures under growth-arresting or growth-enhancing masks. Recent developments in the growth of templated graphene nanostructures are also presented, as exemplified by tens of micron long very well confined and isolated 20-40nm wide graphene ribbons. Scheme for large scale integration of ribbon arrays with Si wafer is also presented.
Mapping Competitive Reduction upon Charging in LiNi<sub>0.8</sub>Co<sub>0.15</sub>Al<sub>0.05</sub>O<sub>2</sub> Primary Particles (2020)

Side reactions involving surface reduction play a critical role in the failure of LiNi0.8Co0.15Al0.05O2 to reach its theoretical capacity as a cathode material for Li-ion batteries. While macroscopic consequences are known, the underlying nanoscopic mechanisms are not fully elucidated. By coupling X-ray spectroscopy with several X-ray microscopy modalities, we have spatially resolved the extent of Ni oxidation at several states of charge and uncovered heterogeneity that is hidden when considering ensemble measurements alone. The use of morphologically controlled particles enabled high-resolution imaging of these materials, uncovering gradients of Ni oxidation states within individual primary particles. At high states of charge, these gradients revealed regions of possible oxygen deficiency extending deeper into the particle than previously observed. Surface-sensitive X-ray coupled scanning tunneling microscopy allows oxidation states to be measured at the material’s surface, showing predominantly NiII in the first atomic layer and mixtures of NiII with NiIII/NiIV already appearing 1.5 nm into the particle. These results reveal the subtle interplay between irreversible surface transformations and the bulk reactions that ultimately define function, which will refine strategies of surface passivation that are key to overcoming current performance limitations.
Iliac vein compression syndrome: Clinical, imaging and pathologic findings (2015)

May-Thurner syndrome (MTS) is the pathologic compression of the left common iliac vein by the right common iliac artery, resulting in left lower extremity pain, swelling, and deep venous thrombosis. Though this syndrome was first described in 1851, there are currently no standardized criteria to establish the diagnosis of MTS. Since MTS is treated by a wide array of specialties, including interventional radiology, vascular surgery, cardiology, and vascular medicine, the need for an established diagnostic criterion is imperative in order to reduce misdiagnosis and inappropriate treatment. Although MTS has historically been diagnosed by the presence of pathologic features, the use of dynamic imaging techniques has led to a more radiologic based diagnosis. Thus, imaging plays an integral part in screening patients for MTS, and the utility of a wide array of imaging modalities has been evaluated. Here, we summarize the historical aspects of the clinical features of this syndrome. We then provide a comprehensive assessment of the literature on the efficacy of imaging tools available to diagnose MTS. Lastly, we provide clinical pearls and recommendations to aid physicians in diagnosing the syndrome through the use of provocative measures.
Using a Microcontroller to Optimize the Bias Voltage of Balanced Photodiodes to Minimize Even-Order Distortion in Analog Fiber-Optic Links (2010)

Use of a microcontroller-based bias board for balanced photodiodes improves even-order distortion cancellation due to voltage dependent responsivity nonlinearities. The bias board improves the second order intermodulation distortion in balanced photodiodes by 8.3 dB.
A Resilient Real-Time Agent-Based System for a Reconfigurable Power Grid (2006)

Reliable electricity has become an essential underpinning for national security in modern society. The fault-tolerant generic framework proposed herein can prevent potential outages from happening through intelligent agent coordination. Instead of limiting the system to manage existing devices, the developed system is adaptive to the future power grid in years to come. This paper proposes a hardware-in-the-loop multi-agent system with embedded models and functions
Letters (1994)

White, Arthur President; Lee, Casey Executive Vice President; Yuan, Hensen 2nd Vice President; Fardon, David Director, Council on Health Policy and Practice; Kahanovitz, Neil Chairman, Ad Hoc committee to the President; Saal, Jeffrey Secretary; Mayer, Thomas Treasurer Author Information
Nasal DNA Methylation is Associated with Childhood Asthma (2018)

We identified novel DNAm variations associated with childhood asthma and suggested new disease-contributing epigenetic mechanisms.
Identification de la Plastine-3 comme nouvel acteur du développement rénal (2020)

L’analyse omique de l’urine est considérée comme une biopsie liquide du rein qui a révolutionné la compréhension des maladies rénales. Les malformations congénitales du rein et du tractus urinaire (CAKUT) sont des maladies génétiquement complexes dont la physiopathologie est encore méconnue. Dans la mesure où la production de liquide amniotique (LA) est principalement due à l’excrétion de l’urine fœtale, l’exploration de son contenu devrait faciliter la compréhension des mécanismes liés au CAKUT. L’objectif de cette étude est donc d’identifier dans le LA de nouveaux acteurs associés au développement rénal pathologique des CAKUT. En comparant par LC-MS/MS le protéome du LA de 22 fœtus sains, 19 fœtus atteints d’une forme peu sévère de CAKUT et 14 fœtus porteurs d’une forme sévère, nous avons identifié la Plastine-3 (PLS3) dont l’abondance augmente graduellement des fœtus contrôles aux fœtus avec un CAKUT sévère. La présence rénale de PLS3 a été validée par immunohistochimie chez les fœtus sains/CAKUT et dans le modèle murin. L’invalidation de PLS3 chez la souris entraîne une augmentation de l’aire glomérulaire, au prorata de la surface corticale, et un épaississement des pédicelles et de la membrane basale glomérulaire. Ces anomalies sont associées à la diminution de l’expression des protéines podocytaires néphrine et podocalyxine, et conduisent à une augmentation significative de l’albuminurie. L’invalidation de PLS3 chez le poisson-zèbre entraîne également à 48 h post-fécondation, une altération de fusion glomérulaire et une augmentation tubulaire proximale ressemblant à un retard de développement. Ainsi, ce travail démontre pour la première fois le rôle de PLS3 dans le développement rénal pathologique des fœtus CAKUT. Des études complémentaires d’invalidation in vitro de PLS3 au sein de lignées podocytaires (AB8-13) et tubulaire (HK-2) permettront de préciser les mécanismes moléculaires en aval de PLS3.
Theoretical study on CO<sub>2</sub> reduction catalyzed by formate dehydrogenase using the cation radical of a bipyridinium salt with an ionic substituent as a co-enzyme (2020)

Formate dehydrogenase from Candida boidinii (CbFDH; EC.1.2.1.2) is a useful enzyme for CO2 reduction to formate in the photoredox system of a visible-light sensitizer and an electron mediator in the presence of an electron donor. The electron mediator, cation radicals of 4,4'-bipyridinium salts (4,4'-BPs) act as the co-enzyme for CbFDH in the CO2 reduction to formate. We found that the CbFDH-catalyzed CO2 reduction to formate could be controlled by the ionic substituents introduced into the cation radical of 4,4'-BPs [Y. Amao, Sustainable Energy Fuels, 2018, 2, 1928-1950]. By using 1,1'-diaminoethyl-4,4'-bipyridinium salt (DABP), 1-aminoethyl-1'-methyl-4,4'-bipyridinium salt (AMBP), 1,1'-carboxymethyl-4,4'-bipyridinium salt (DCBP), and 1-carboxymethyl-1'-methyl-4,4'-bipyridinium salt (CMBP), the introduction of an amino-group into 4,4'-BP accelerates the CbFDH-catalyzed CO2 reduction to formate, while the introduction of a carboxy-group into 4,4'-BP slows the CO2 reduction to formate. This work clarified the direct interaction of the cation radicals of DABP, DCBP, AMBP, CMBP, and MV in the substrate-binding site of CbFDH by the docking simulation. In addition, a mechanistic investigation for the CbFDH-catalyzed CO2 reduction to formate with cation radicals of DABP, DCBP, AMBP, CMBP, and MV was carried out based on the energy of molecular orbitals calculated by density functional theory (DFT).
Randomized, double‐blind, placebo‐controlled study of safety and efficacy of miltefosine in antihistamine‐resistant chronic spontaneous urticaria (2012)

The results of this study indicate that miltefosine is an effective and safe treatment option for CSU patients who do not respond to standard-dosed antihistamines.
Randall’s plaque in stone formers originates in ascending thin limbs (2018)

Randall's plaque, an attachment site over which calcium oxalate stones form, begins in the basement membranes of thin limbs of the loop of Henle. The mechanism of its formation is unknown. Possibly, enhanced delivery of calcium out of the proximal tubule, found in many stone formers, increases reabsorption of calcium from the thick ascending limb into the interstitium around descending vasa recta, which convey that calcium into the deep medulla, and raises supersaturations near thin limbs ("vas washdown"). According to this hypothesis, plaque should form preferentially on ascending thin limbs, which do not reabsorb water. We stained serial sections of papillary biopsies from stone-forming patients for aquaporin 1 (which is found in the descending thin limb) and the kidney-specific chloride channel ClC-Ka (which is found in the ascending thin limb). Plaque (which is detected using Yasue stain) colocalized with ClC-Ka, but not with aquaporin 1 (χ<sup>2</sup> = 464, P < 0.001). We conclude that plaque forms preferentially in the basement membranes of ascending thin limbs, fulfilling a critical prediction of the vas washdown theory of plaque pathogenesis. The clinical implication is that treatments such as a low-sodium diet or thiazide diuretics that raise proximal tubule calcium reabsorption may reduce formation of plaque as well as calcium kidney stones.
Ethics, Occupational Medicine and ACOEM Reply (1995)

Teichman, Ron MD, MPH; Cassidy, Susan O. MD, JD; Brandt-Rauf, Paul MD; Cannella, Joseph MD; Gresch, Elizabeth MD; Goldberg, Robert MD; McCunney, Robert MD; Rischitelli, D Gary MD; Wester, Mary Sue MD; Zanick, David C. MD Author Information
Higher neuronal discharge rate in the motor area of the subthalamic nucleus of Parkinsonian patients (2014)

In Parkinson's disease, pathological synchronous oscillations divide the subthalamic nucleus (STN) of patients into a dorsolateral oscillatory region and ventromedial nonoscillatory region. This bipartite division reflects the motor vs. the nonmotor (associative/limbic) subthalamic areas, respectively. However, significant topographic differences in the neuronal discharge rate between these two STN subregions in Parkinsonian patients is still controversial. In this study, 119 STN microelectrode trajectories (STN length > 2 mm, mean = 5.32 mm) with discernible oscillatory and nonoscillatory regions were carried on 60 patients undergoing deep brain stimulation surgery for Parkinson's disease. 2,137 and 2,152 multiunit stable signals were recorded (recording duration > 10 s, mean = 21.25 s) within the oscillatory and nonoscillatory STN regions, respectively. Spike detection and sorting were applied offline on every multiunit stable signal using an automatic method with systematic quantification of the isolation quality (range = 0-1) of the identified units. In all, 3,094 and 3,130 units were identified in the oscillatory and nonoscillatory regions, respectively. On average, the discharge rate of better-isolated neurons (isolation score > 0.70) was higher in the oscillatory region than the nonoscillatory region (44.55 ± 0.87 vs. 39.97 ± 0.77 spikes/s, N = 665 and 761, respectively). The discharge rate of the STN neurons was positively correlated to the strength of their own and their surrounding 13- to 30-Hz beta oscillatory activity. Therefore, in the Parkinsonian STN, beta oscillations and higher neuronal discharge rate are correlated and coexist in the motor area of the STN compared with its associative/limbic area.
Vision System for Micromanipulation (2002)

Recently, in connection with down-sizing of manipulated objects in fields such as biology and medical treatment, the establishment of dexterous micromanipulation is crucial. Dexterous micro manipulation using a two finger microhand with 12-DOF and an optical microscope has been developed for applications such as assembling micromachines and manipulating cells and microbes. Basic experiments showed two problems, a more compact hand mechanism fit in the limited microscope workspace and less focusing work for an operator. A 3-DOF parallel mechanism is designed for a new finger module. To decrease focusing during manipulation, an autofocusing and tracking mechanism is developed using microscope image data. The focusing algorithm uses color and brightness to make tracking smooth. Experiments include tracking a moving object and recognizing and localizing a target in a focal plane.