gebhart/patrepeval huggingface dataset:
Histopathologic Clusters Differentiate Subgroups Within the Nonspecific Diagnoses of CAN or CR: Preliminary Data from the DeKAF Study (2009)

The nonspecific diagnoses 'chronic rejection''CAN', or 'IF/TA' suggest neither identifiable pathophysiologic mechanisms nor possible treatments. As a first step to developing a more useful taxonomy for causes of new-onset late kidney allograft dysfunction, we used cluster analysis of individual Banff score components to define subgroups. In this multicenter study, eligibility included being transplanted prior to October 1, 2005, having a 'baseline' serum creatinine < or =2.0 mg/dL before January 1, 2006, and subsequently developing deterioration of graft function leading to a biopsy. Mean time from transplant to biopsy was 7.5 +/- 6.1 years. Of the 265 biopsies (all with blinded central pathology interpretation), 240 grouped into six large (n > 13) clusters. There were no major differences between clusters in recipient demographics. The actuarial postbiopsy graft survival varied by cluster (p = 0.002). CAN and CNI toxicity were common diagnoses in each cluster (and did not differentiate clusters). Similarly, C4d and presence of donor specific antibody were frequently observed across clusters. We conclude that for recipients with new-onset late graft dysfunction, cluster analysis of Banff scores distinguishes meaningful subgroups with differing outcomes.
Association of Circulating MicroRNA-124-3p Levels With Outcomes After Out-of-Hospital Cardiac Arrest (2016)

clinicaltrials.gov Identifier: NCT01020916.
Total Synthesis of Syringolin A and B (2010)

Total syntheses of two recently discovered proteasome inhibitors, syringolin A and B, are reported. The key to our approach was creation of the alpha,beta-unsaturated 12-membered lactam via intramolecular Horner-Wadsworth-Emmons reaction. Such reactions have been broadly used to prepared macrolactones, but this work presents a rarer example of its application to macrolactams. The final steps involved attachment of the bis(valinyl)urea side chain using peptide coupling procedures, including a method based on the unprotected valine N-carboxy anhydride. The additional alkene of syringolin A was created through cross-metathesis.
CCDC 1044706: Experimental Crystal Structure Determination (2017)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Supplementary Figure 6 from PARP-1 Inhibition as a Targeted Strategy to Treat Ewing's Sarcoma (2023)

&lt;p&gt;PDF file - 422K&lt;/p&gt;
PROTRACTED PARENTERAL DRUG INFUSION IN AMBULATORY SUBJECTS USING AN IMPLANTABLE INFUSION PUMP (1977)

Cell-aware test (CAT) explicitly targets defects inside library cells and therefore significantly reduces the amount of test escapes compared to conventional automatic test pattern generation (ATPG). Our CAT flow consists of three steps: (1) defect-location identification (DLI), (2) defect characterization based on&lt;br/&gt;detailed analog simulation of the cells, and (3) cell-aware automatic test pattern generation (ATPG). This paper focuses on Step 1, as quality and cost are determined by the set of cell-internal defect locations considered in the remainder of the flow. Based on technology inputs from the user and a parasitic extraction (PEX) run that analyzes the cell layouts, we derive a set of open defects on and short defects between both transistor terminals and intra-cell interconnects. The full set of defect locations is stored for later use during failure analysis. Through dedicated DLI algorithms, we identify a compact subset of defect locations for defect characterization and ATPG, in which we include only&lt;br/&gt;one representative defect location for each set of equivalent defects locations. For Cadence’s GPDK045 library, the compact subset contains only 2.8% of the full set of defect locations and reduces the time required for defect characterization with the same ratio.
ChemInform Abstract: Catalyst‐Controlled Site‐Selectivity Switching in Pd‐Catalyzed Cross‐Coupling of Dihaloarenes (2015)

Abstract Review: 40 refs.
On the effect of strong internal waves on surface waves (2003)

Propagation of gravity-capillary surface waves (SW) in the presence of a current produced by a large-amplitude internal wave (IW) is considered in the short-wave approximation. The evolution of trajectories of SW packets in the "coordinate-wave vector" domain with the change of an IW amplitude is investigated. In particular, the authors have studied the location of maxima and minima of the surface-wave spectral density, W. It is shown that the minimum of W for an arbitrary wavelength lies above a large-amplitude internal solitary wave (IW soliton) when both IW and SW propagate in the same direction, the maximum of W being located over a forward slope of the IW soliton. It is in agreement with the results of the Coastal Ocean Probing Experiment (COPE), where extremely strong internal solitary waves were observed. Some numerical results with the use of a kinetic equation are also presented.
An agent-based distributed multimedia service environment (2002)

This paper describes our experiences in using agent-based technology for the design of distributed multimedia service environments. These new systems must be able to operate in a constantly evolving enterprise and to adapt to unexpected contingencies or failures in hardware, software and even human resources. Our Multi-Agent-Architecture for Networked Applications (MANA) is based on the notion of an organizational network of agents that cooperate to provide services to internal and external customers of the enterprise. Key to the approach is the decoupling of service definition and provisioning through a declarative model of the enterprise.
Special Issue on: Discourse organisation through time and space/L'organisation du discours à travers le temps et l'espace (2005)

Nous nous proposons, dans ce numéro, d'aborder l'organisation du discours (écrit et oral) sans nous restreindre à un système d'analyse spécifique. De ce fait, nous sommes amenées à circonscrire notre thématique en nous donnant des points d'entrée privilégiés: le choix du temps et de l'espace, en même temps qu'il répond à cette nécessité de borner le domaine d'étude, reflète la prégnance de ces deux paramètres dans la construction et l'interprétation du discours.
Association in Multifactorial Traits: How to Deal with Rare Observations? (2004)

To detect the role of a candidate gene for a trait in a sample of individuals, we may test SNP haplotype or diplotype effects. For a limited sample size, many haplotype or diplotype categories may contain few individuals. This involves a power decrease when testing the association between the trait and the haplotypes or diplotypes as these categories provide little additional information while increasing the degrees of freedom. The present paper proposes a new strategy to group rare categories based on a measure of similarity between haplotypes or diplotypes and compares it to two other possible strategies to deal with rare categories: a SNP selection strategy based on haplotype diversity, and a grouping strategy that pools all rare categories into a single baseline group. This comparison is performed by means of simulation under four scenarios. We show that this new strategy shows the largest increase in power irrespective of the model underlying the candidate gene in the studied trait. This strategy therefore provides a powerful alternative to currently used methods to reduce the number of rare categories.
Coalitional Games for Distributed Eavesdroppers Cooperation in Wireless Networks (2010)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et a ̀ la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
[Treatment with fludarabine of lymphoid neoplasms with low grade malignity resistant to treatment or in relapse]. (1996)

Fludarabine is an active agent in patients with low-grade lymphoid malignancies refractory to the treatment or in relapse. The possibility of obtaining molecular remissions makes this agent specially interesting in those therapies including hemopoietic progenitors transplantation as intensification treatment.
MULLITE GLASS CERAMICS PRODUCTION FROM COAL ASH AND ALUMINA BY HIGH TEMPERATURE PLASMA (2009)

The waste and highly hazardous coal ash from the power plants is proved to be a potential source for the production of low cost mullite glass ceramics when mixed with alumina at very high temperatures produced by plasma. In this present work, the coal ash and alumina are mixed at different weight \npercentages and treated with high temperature plasma produced by Transfer Arc Plasma Torch (TAP) of \n10 kW power. The XRD patterns confirm that the complete single phase homogeneous mullitization occurs when 50% of coal ash is mixed with 50% of alumina. The SEM results also show that the formation of elongated needle - like mullite glass ceramics at very high temperatures. The TG – DTA \nanalysis reveals that an endothermic phase transition and mullitization temperature occurs at 920°C when equal weight % alumina mixed with equal weight % of coal ash. The sharpened strong endothermic peak at 920°C reflects the homogeneity of formed mullite. The results show that the lowcost single phase mullite is obtained in a very short period of time (5 minutes) is found to be a key factor with required microstructure.
A report of the 17th congress of the Japanese Society for Regenerative Medicine (2018)

The 17th Congress of the Japanese Society for Regenerative Medicine was held on March 21-23, 2018 at PACIFICO Yokohama (Kanagawa Prefecture) with 3860 participants. The theme of the congress was 'The Integration of Wisdom from All Sectors.' With this theme, this congress aimed to provide people from all sectors (including individuals from various industries, regulatory authorities, academia, and citizens) with opportunities for exchanging views on regenerative medicine under one roof. A broad spectrum of topics related to regenerative medicine was covered by one presidential lecture, one keynote lecture, one collaborative lecture by the Congress Chair and the Governor of Kanagawa Prefecture, three special lectures (six topics), four award lectures, 43 symposia (235 talks), 337 oral presentations (59 sessions), 358 poster presentations (43 sessions), 25 co-organized seminars (35 talks), two sessions for junior high school and high school students (basic and advanced), and the state-of-the-art technology showcase (158 organizations).
Role of Capping Agents in the Synthesis of Salicylate-Capped Zinc Oxide Nanoparticles (2020)

Capping agents are often used for controlling the size, aggregation, and properties of nanoparticles. To guide the design of improved nanomaterials for targeted performance, one can use mechanistic insights into the interactions between capping agents and nanoparticles. Here, we employ density functional theory (DFT), reactive force-field molecular dynamics (ReaxFF MD) simulations, and optical spectroscopy to study the interactions between salicylate, as a model capping agent, and zinc oxide (ZnO) nanoparticles. We find that salicylate strongly interacts with the nanoparticle via the formation of O–Zn bonds in a distorted six-membered coordination ring structure. We describe the mechanisms of capping of ZnO nanoparticles by salicylate via three different binding modes. Simulations indicate that salicylate undergoes dissociative adsorption at the highly active surface Zn sites via a hydrogen-transfer process, thereby forming a tridentate configuration. The water-mediated interaction also facilitates the dissociative adsorption, leading to two salicylate O atoms coordinating with a surface Zn atom, while the other salicylate O atom bonds with another surface Zn atom. For molecular adsorption, binding free energies indicate that salicylate binds more strongly to ZnO, often in a bidentate configuration, than water does. The formation of the salicylate–ZnO complex is substantiated by UV–visible and Fourier transform infrared spectra. We find that the C═O stretching mode of salicylate becomes softened when it interacts with the nanoparticle, suggesting chemisorption of salicylate on ZnO. Although DFT predicts strong interaction between salicylate and ZnO, ReaxFF MD simulation indicates the moderate interaction between these two components in aqueous solution. Water molecules in close contact with the nanoparticle surface undergo dissociation, thus resulting in a surface hydroxyl, a reactive oxygen species that may influence the nanoparticle’s catalytic properties. The atomic-level information provided here can guide the selection process of salicylate as an appropriate agent for ZnO nanoparticle synthesis when strong interactions of particles with capping agents are required.
Integrating Cognitive-Behavioral and Expressive Therapy Interventions: Applying the Trauma Outcome Process in Treating Children with Sexually Abusive Behavior Problems (2002)

This study examines correlates of offender confession in criminal sexual conduct cases involving children. The cases consist of all closed court files (N=318), spanning the last 10 years from a single jurisdiction. This jurisdiction has a community-wide protocol for handling child sexual abuse cases, a high rate of charging (69%), a high rate of confession (64%), and high rates of pleas to sex crimes (77%). To determine what factors were associated with suspect confession before adjudication, we examined characteristics of the suspect, the child, the abuse, and the system using bi-variate and multi-variate analysis. The following four variables are associated with suspect confession: (1) having the state police conducting the law enforcement part of the investigation, (2) more serious abuse, (3) younger age of the suspect, and (4) having a court appointed (as opposed to a retained) attorney.
Hyperbolic Phonon Polaritons in Suspended Hexagonal Boron Nitride (2018)

Highly confined and low-loss hyperbolic phonon polaritons in hexagonal boron nitride possess properties analogous to surface plasmon polaritons, but with enhanced confinement and lower loss. Their properties have been so far mostly studied on dielectric substrates, which provide an asymmetric environment for polariton propagation, and add to damping. In this work, we investigate hyperbolic phonon polaritons over suspended hexagonal boron nitride, showing remarkable properties, including elongated polariton wavelength and reduced damping, up to 18% lower compared to dielectric-backed samples. We use real-space nanoimaging of the polaritons in hexagonal boron nitride to demonstrate and visualize these effects. Our results indicate that suspended boron nitride offers better figures of merit for polariton transport, which are generalizable to other polaritonic materials, and they may be explored in heterostructures for advanced nanophotonic applications.
Laser-Assisted Machining of Reaction Sintered Mullite Ceramics (2002)

The present study focuses on the evaluation of the laser-assisted machining (LAM) of pressureless sintered mullite ceramics. Due to mullite’s low thermal diffusivity and tensile strength, a new method for applying laser power is devised to eliminate cracking and fracture of the workpiece during laser heating. The LAM process is characterized in terms of cutting force, surface temperature, chip morphology, tool wear, surface roughness and subsurface damage for a variety of operating conditions. Estimated material removal temperatures and the ratio of the feed force to the main cutting force are used to determine material removal mechanisms and regimes for brittle fracture and semi-continuous and continuous chip formation. Surface roughness and subsurface damage are compared between typical parts produced by LAM and grinding. Tool wear characteristics are investigated for variations in laser power, and hence material removal temperature, during LAM of mullite with carbide tools.
New brain lesions in a patient with sarcoidosis: is it neurosarcoidosis? (2014)

A 45-year-old woman with pulmonary sarcoidosis diagnosed 5 years previously, who was on treatment with prednisone and methotrexate for 1year, developed partial seizure with secondary generalization. MRI showed three non-cavitary enhancing lesions in the cerebello-occipital region. These lesions were presumed to be neurosarcoidosis. Methotrexate was discontinued, prednisone dose was increased and azathiopurine and levetiracetam were added. While on treatment, follow up imaging showed enlarging brain lesions. Biopsy of the lesions showed Epstein Barr virus (EBV) positive diffuse B cell lymphoma. Immunosuppressants were tapered off and she was begun on Rituximab. Because of lack of improvement after 4 cycles of Rituximab, she was then treated with high dose Methotrexate and Temozolamide. We present this case as a diagnostic challenge. New enhancing brain lesions occurring in a patient with long standing sarcoidosis, while likely to be neurosarcoidosis, may be due to a complication of immunosuppressant therapy. The need for early biopsy, if the lesions do not improve, should be considered.
Adapting Surgical Models to Individual Hospitals Using Transfer Learning (2012)

Preoperative models to assess surgical mortality are important clinical tools in determining optimal patient care. The traditional approach to develop these models has been primarily centralized, i.e., it uses surgical case records aggregated across multiple hospitals. While this approach of pooling greatly increases the data size, the resulting models fail to reflect individual variations across hospitals in terms of patients and the delivery of care. We hypothesize that this process can be improved through adapting the multi-hospital data model to an individual hospital. This approach simultaneously leverages the large multi-hospital data and the patient-and-case mix at individual hospitals. We explore transfer learning to refine surgical models for individual hospitals in the framework of support vector machine by using data from both the National Surgical Quality Improvement Program and a single hospital. Our results show that transferring models trained on multi-hospital data to an individual hospital significantly improves discrimination for surgical mortality at the individual provider level.
Ferrosilicochromium‐Filled Polymer‐Derived Ceramics (2011)

Rectangular green bodies fabricated from a granulated mixture of polymethylsilsesquioxane (PMS), ferrosilicochromium (FeSiCr), and SiC were cross‐linked in a warm press at 240°C under a pressure of 9 MPa. The samples were then pyrolyzed at 950°C and subsequently heat treated at 1275°C in N 2 atmosphere at pressures up to 5 MPa. For the composites with 25 vol% FeSiCr, a total linear shrinkage of &lt;7% was measured while the residual porosity decreased to 3%. A bending strength of ∼285 MPa, fracture toughness of ∼3.7 MPa m 1/2 , hardness of ∼9.5 GPa, and elastic modulus of ∼186 GPa were evaluated.
Phosphodiester Amidates of Unsaturated Nucleoside Analogues as Anti-HIV Agents (1997)

Abstract Lipophilic phosphodiester L-alaninates of acyclic unsaturated nucleoside analogues 1d, 1e, 2d, 2e, 3d, 3e, 4d and 5d were prepared and their antiretroviral activity was examined in ATH8 cell culture infected with HIV-1. A possible mechanism of action of these analogues is discussed.
Validation of claims‐based diagnostic and procedure codes for cardiovascular and gastrointestinal serious adverse events in a commercially‐insured population (2010)

The results suggest that, for certain adverse events, claims data can serve as the basis for pharmacoepidemiology research and drug safety surveillance in the US.
Protective Effect and Potential Antioxidant Role of Kakadu Plum Extracts on Alcohol-Induced Oxidative Damage in HepG2 Cells (2021)

Serial alcohol consumption causes alcoholic liver disease (ALD), which can lead to fatty liver, hepatitis, and cirrhosis. Terminalia ferdinandiana (Kakadu plum) is an indigenous fruit of Australia, which is utilized as a functional food. It is a commercially important antioxidant as it contains a more eloquent level of ascorbic acid than other oranges. In this study, we analyzed the chemical constituents of vitamin C, gallic acid, ellagic acid, and daidzin via High-performance liquid chromatography (HPLC) in the Kakadu plum from two different regions including the Northern Territory (NT) and Western Australia (WA), and compared their biochemical properties. The vitamin C content was much higher (almost 70%) in Kakadu plum (KKD) from the NT than WA. Moreover, ROS generation was inhibited significantly in HepG2 (human hepatoma) cells with the KKD-NT extract treatment when compared to the KKD-WA extract treatment. The cytotoxicity produced by ethanol was significantly suppressed in response to the treatment with both of the samples. In addition, our samples (KKD-NT and KKD-WA) increased the activity of two key enzymes involving alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) that metabolize ethanol. These results show the biochemical confirmation of the mechanism by which KKD exhibits its biological functions including relief from alcohol hangovers as well as protection of the liver cells by the suppression of ROS production and toxic insults.
Volatile Organic Compounds Enhance Allergic Airway Inflammation in an Experimental Mouse Model (2012)

Our results demonstrate that exposure to VOCs may increase the allergic immune response by interfering with DC function and by inducing oxidative stress and has therefore to be considerate as risk factor for the development of allergic diseases.
Effects of crosslink density in zwitterionic hydrogel coatings on their antifouling performance and susceptibility to silt uptake (2020)

Hydrogel coatings effectively reduce the attachment of proteins and organisms in laboratory assays, in particular when made from zwitterionic monomers. In field experiments with multiple species and non-living material, such coatings suffer from adsorption of particulate matter. In this study, the zwitterionic monomer 3-[<i>N</i>-(2-methacryloyloxyethyl)-<i>N</i>,<i>N-</i>dimethylammonio] propanesulfonate (SPE) was copolymerized with increasing amounts of the photo-crosslinker benzophenon-4-yloxyethyl methacrylate (BPEMA) to systematically alter the density of crosslinks between the polymer chains. The effect of increasing crosslink density on the antifouling (AF) performance of the coatings was investigated in laboratory assays and fields tests. In both cases, the AF performance was improved by increasing the crosslinker content. The coatings reduced protein, diatom, and barnacle accumulation, and showed better resistance to biomass accumulation. The findings underline that the marine AF performance of hydrogel coatings does not only depend on the specific chemical structure of the polymers, but also on their physico-chemical properties such as rigidity and swelling.
100 Gbit/s WDM (20 Gbit/s × 5 channels) solitontransmissionover 10000 km using in-line synchronous modulationand optical filtering (1997)

A 100 Gbit/s WDM (20 Gbit/s × 5 channels) soliton data signal was successfully transmitted over 10000 km using in-line synchronous modulation and narrow band optical filtering. A four-segment dispersion decreasing configuration was used to reduce the soliton interaction and the dispersive waves.