gebhart/patrepeval huggingface dataset:
Volumetric Correlates of Spatiotemporal Working and Recognition Memory Impairment in Aged Rhesus Monkeys (2010)

Spatiotemporal and recognition memory are affected by aging in humans and macaque monkeys. To investigate whether these deficits are coupled with atrophy of memory-related brain regions, T(1)-weighted magnetic resonance images were acquired and volumes of the cerebrum, ventricles, prefrontal cortex (PFC), calcarine cortex, hippocampus, and striatum were quantified in young and aged rhesus monkeys. Subjects were tested on a spatiotemporal memory procedure (delayed response [DR]) that requires the integrity of the PFC and a medial temporal lobe-dependent recognition memory task (delayed nonmatching to sample [DNMS]). Region of interest analyses revealed that age inversely correlated with striatal, dorsolateral prefrontal cortex (dlPFC), and anterior cingulate cortex volumes. Hippocampal volume predicted acquisition of the DR task. Striatal volume correlated with DNMS acquisition, whereas total prefrontal gray matter, prefrontal white matter, and dlPFC volumes each predicted DNMS accuracy. A regional covariance analysis revealed that age-related volumetric changes could be captured in a distributed network that was coupled with declining performance across delays on the DNMS task. This volumetric analysis adds to growing evidence that cognitive aging in primates arises from region-specific morphometric alterations distributed across multiple memory-related brain systems, including subdivisions of the PFC.
Nonlinear Optical Properties of Bacteriorhodopsin (1999)

Abstract : We demonstrated for the first time a saturable polarization rotation in Bacteriorhodopsin that acts as an effective optical limiter. Using a multiple pass scheme and cross polarizes we achieved a ninety degree polarization rotation of a probe beam and a corresponding optical density of 10(exp -4).
AlGaInP-based Vertical-Cavity Surface-Emitting Lasers for Sensoring and Polarization Switching (2011)

We present a detailed analysis of the transverse beam profile and the polarization characteristics of red‐emitting oxide‐confined vertical‐cavity surface‐emitting lasers (VCSELs). We demonstrate that oxide aperture sizes smaller than 6 μm are required for emission in fundamental mode. We further show first steps towards integrating beam shaping optics directly into the top mirror of the VCSEL.
A Pharmacokinetic and Pharmacodynamic Comparison of Synthetic and Recombinant Oral Salmon Calcitonin (2009)

The aim of this study was to assess the bioavailability and pharmacodynamic efficacy of synthetic salmon calcitonin (ssCT) and recombinant salmon calcitonin (rsCT) in healthy postmenopausal women. The study was a single-blind, randomized study. Participants were 36 postmenopausal women 62 to 74 years old, randomly assigned to a comparison of dosing with ssCT (n = 12) or rsCT (n = 24) given in the morning at 08:00. Study parameters were plasma CT levels measured up to 2 hours postdose and changes in the bone resorption marker serum CTX-I and the cartilage degradation marker urine CTX-II measured up to 4 hours postdose. For both formulations, peak plasma concentrations were obtained 15 minutes after dosage, and no statistically significant differences in the uptake of CT were observed. Measurement of bone resorption and cartilage degradation markers displayed comparable responses, with AUCs of relative change of serum CTX-I of -250% x hours and relative change of urine CTX-II of -180% x hours during the 4-hour observation period. In conclusion, oral synthetic and recombinant calcitonin displayed comparable pharmacodynamic and kinetic properties.
Phase 2 trial of ixazomib, cyclophosphamide, and dexamethasone for previously untreated light chain amyloidosis (2022)

Bortezomib, a proteasome inhibitor (PI), has shown efficacy in the treatment of newly diagnosed and relapsed light chain (AL) amyloidosis, and is often used in combination with cyclophosphamide and dexamethasone. Ixazomib is the first oral PI to be approved in routine practice but has not yet been evaluated in the upfront treatment setting. Newly diagnosed AL amyloidosis patients with measurable disease and adequate organ function were enrolled. The primary objective was to determine the hematologic response rate of ixazomib in combination with cyclophosphamide and dexamethasone. Treatment was given for 12 cycles, followed by ixazomib maintenance until progression. Thirty-five patients were included; their median age was 67 years, and 69% were male. Major organ involvement included heart (66%) and kidneys (54%). A median of 4 induction cycles (range, 1-12) were administered. The overall hematologic response to induction was 63% and included complete response in 11.4% and very good partial response in 37.1% of patients. One patient was upstaged to complete response during maintenance. The most common reason for going off study was the institution of alternate therapy (61%). With a median follow-up of 29.7 months for the living patients, the 2-year progression-free survival and overall survival were 74% and 78%, respectively. The median time to alternate therapy was 7.5 months. Grade ≥3 hematologic and nonhematologic adverse events occurred in 23% and 49% of patients. Given ixazomib's favorable toxicity profile, which is an important advantage for the typically frail AL population, further evaluation of ixazomib in other combinations in the upfront setting is warranted. This trial was registered at www.clinicaltrials.gov as #NCT01864018.
Ring Expansion‐Annulation Strategy for the Synthesis of Substituted Azulenes and Oligoazulenes. Part 2. Synthesis of Azulenyl Halides, Sulfonates, and Azulenylmetal Compounds and Their Application in Transition‐Metal‐Mediated Coupling Reactions. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Effects of climate on organic carbon and the ratio of planktonic to benthic primary producers in a subarctic lake during the past 45 years (2009)

The effects of climatic variables on lake‐water total organic carbon (TOC) concentrations and benthic and pelagic primary producers during the past 45 yr were assessed using the sediment records of two subarctic lakes, one with mires and one without mires connected to the lake. The lake with a mire showed large and synchronous changes in the planktonic to benthic (P : B) ratio of diatoms and concentrations of TOC inferred from nearinfrared spectroscopy. During periods of warm temperatures, high precipitation, and long ice‐free conditions, we inferred high TOC in the lake, and the diatom community was dominated by planktonic species. The stable carbon isotopic (Δ 13 C) values of sediment organic matter were negatively correlated with inferred TOC concentration and P :B ratio. We suggest that the changes in TOC and P : B ratio were a result of changing climate, permafrost degradation, and related changes in the catchment. Terrestrial organic matter, by its strong effect on the penetration of light through the lake water, possibly affected the habitats available for benthic photosynthesis and thus the Δ13C of the sediment organic matter. The large changes in recent times may also be because of unusually long ice‐free periods, warmer temperatures, and other associated limnological changes. The lake with no mire next to the lake showed only minor changes in lake‐water TOC during the same period and P :B ratio remained almost constant until the past 5 yr, when the P :B ratio increased rapidly. The observed changes in P :B ratio within this lake may be because of complex interactions of several climate‐related variables.
Cognitive radio kit framework (2013)

This paper presents an overview of a Cognitive Radio Kit, an open software defined radio framework developed specifically to enable experimental research in cognitive radio and dynamic spectrum techniques. Currently available open software defined platforms are limited by performance and bandwidth constraints, and inadequate frequency tuning range at the RF front-end. The proposed platform addressed those limitations by providing the ability to dynamically add hardware based acceleration for baseband processing, coupled with up to four wide-tuning range RF front-ends. The challenge resides in defining the architecture and programming model for the platform. All those considerations along with an application example are discussed and presented in this paper.
Self-Formed Barrier with Cu-Mn alloy Metallization and its Effects on Reliability (2006)

Advancement of semiconductor devices requires the realization of an ultra‐thin (less than 5 nm thick) diffusion barrier layer between Cu interconnect and insulating layers. Self‐forming barrier layers have been considered as an alternative barrier structure to the conventional Ta/TaN barrier layers. The present work investigated the possibility of the self‐forming barrier layer using Cu‐Mn alloy thin films deposited directly on SiO2. After annealing at 450 °C for 30 min, an amorphous oxide layer of 3–4 nm in thickness was formed uniformly at the interface. The oxide formation was accompanied by complete expulsion of Mn atoms from the Cu‐Mn alloy, leading to a drastic decrease in resistivity of the film. No interdiffusion was observed between Cu and SiO2, indicating an excellent diffusion‐barrier property of the interface oxide.
Robust resource allocation for predictive video streaming under channel uncertainty (2014)

Novel mobility-aware resource allocation schemes have recently been introduced for efficient transmission of stored videos. The essence of such mechanisms is to lookahead at the future rates users will experience, and then strategically buffer content into user devices when they are at peak radio conditions. For example, a user approaching poor coverage will be preallocated additional video segments to ensure smooth streaming. Advances in mobility prediction and real-time radio environment map updates are driving forces for such Predictive Video Streaming (PVS) mechanisms. Although previous efforts have demonstrated the large potential gains of PVS, ideal channel predictions were assumed. This paper addresses the problem of channel uncertainty in PVS, and proposes a robust resource allocation framework that 1) models channel uncertainty, 2) solves the PVS problem with a tunable level of quality of service guarantees, and 3) learns the degree of uncertainty, and adapts the channel model accordingly. Numerical results demonstrate the effectiveness of the proposed approach for PVS under channel variability.
Epitaxial Al2O3(0001)/Cu(111) Template (2016)

status: Published
Comparing and ranking hospitals based on outcome: results from The Netherlands Stroke Survey (2009)

In comparing and ranking hospitals, case-mix-adjusted random effect estimates and the expected ranks are more robust alternatives to traditional fixed effect estimates and simple rankings.
Differential risk factors for colonization of the upper respiratory tract with Gram-positive bacteria between subpopulations with high income inequality (2016)

Welcome to Annals of Global Health,Annals of Global Health is a peer-reviewed, fully open access, online journal dedicated to publishing high quality articles dedicated to all aspects of global health. The journal's mission is to advance global health, promote research, and foster the prevention and treatment of disease worldwide. Its goals are to improve the health and well-being of all people, advance health equity, and promote wise stewardship of the earth's environment. The latest journal impact factor is 3.64.Annals of Global Health is supported by the Program for Global Public Health and the Common Good at Boston College. It was founded in 1934 by the Icahn School of Medicine at Mount Sinai as the Mount Sinai Journal of Medicine. It is a partner journal of the Consortium of Universities for Global Health. Authors of articles accepted for publication in Annals of Global Health will be asked to pay an Article Publication Charge (APC) to cover publication costs. This charge can normally be sourced from your funder or institution. We are committed to supporting authors from all countries to publish their work in Annals of Global Health regardless of national income level, and to achieve this goal, we waive the Article Publication Charge for manuscripts where all authors are from low-income or lower-middle-income countries (as defined by the World Bank). From time to time, Annals of Global Health publishes Special Collections, a series of articles organized around a common theme in global health. Recent Special Collections have included “Strengthening Women’s Leadership in Global Health”, “Decolonizing Global Health Education”, and “Capacity Building for Global Health Leadership Training”. Global health workers interested in developing a Special Collection are strongly encouraged to contact the Managing Editor in advance to discuss the project.
Formation of a Ni-Based Glassy Alloy in Centimeter Scale (2007)

The effect of B addition on the glass formation in the Ni60Pd20P20 alloy has been investigated. The composition containing 3 at % of B was found to show a drastically improved glass-forming ability. A glassy Ni60Pd20P17B3 alloy rod was prepared with a diameter of 12 mm by a water quenching technique. It is so far the first time to prepare a Ni-based bulk glassy alloy with a diameter over 1 cm. The glassy Ni60Pd20P17B3 alloy also exhibits good mechanical properties, such as high strength of 2060 MPa and a large plastic strain of 0.08 under a compressive load.
SPR Sensor Chip for Detection of Small Molecules Using Molecularly Imprinted Polymer with Embedded Gold Nanoparticles (2005)

Molecularly imprinted polymer gel with embedded gold nanoparticle was prepared on a gold substrate of a chip for a surface plasmon resonance (SPR) sensor for fabricating an SPR sensor sensitive to a low molecular weight analyte. The sensing is based on swelling of the imprinted polymer gel that is triggered by an analyte binding event within the polymer gel. The swelling causes greater distance between the gold nanoparticles and substrate, shifting a dip of an SPR curve to a higher SPR angle. The polymer synthesis was conducted by radical polymerization of a mixture of acrylic acid, N-isopropylacrylamide, N,N'-methylenebisacrylamide, and gold nanoparticles in the presence of dopamine as model template species on a sensor chip coated with allyl mercaptan. The modified sensor chip showed an increasing SPR angle in response to dopamine concentration, which agrees with the expected sensing mechanism. Furthermore, the gold nanoparticles were shown to be effective for enhancing the signal intensity (the change of SPR angle) by comparison with a sensor chip immobilizing no gold nanoparticles. The analyte binding process and the consequent swelling appeared to be reversible, allowing one the repeated use of the presented sensor chip.
Computer aided analysis of gas exchange in pear fruit packages during long distance transport (2018)

ISHS VII International Conference on Managing Quality in Chains (MQUIC2017) and II International Symposium on Ornamentals in association with XIII International Protea Research Symposium Computer aided analysis of gas exchange in pear fruit packages during long distance transport
Iterative Creation and Analysis of Generic Ideation Spaces for SMEs (2014)

Inspired by successful educational ideation spaces such as Stanford d.school and Aalto DF, we wonder how to set up an industry-related ideation space for Swiss SMEs? Thus, we ask (1) which strategy must be applied to acquire knowledge for a workshop and ideation space concept, both adapted to Swiss SME needs?, and (2) what key learnings are necessary to deduce the concepts for Swiss SMEs? The first research question is addressed with an evaluation of strategies, whereas the applied criteria were derived from the industrial and cultural context. For addressing the second research question, we triangulated the four methods interviews, questionnaires, feedback, and own observations. Our results are two-fold. First, the chosen iterative approach enabled us gaining knowledge about the needs of Swiss’ SMEs. Second, resulting from the pilot workshops, we cluster our key learnings under the topics: workshop concept, creativity stimuli, cultural requirements, and business needs.
Mutant isolation and molecular cloning of mre genes, which determine cell shape, sensitivity to mecillinam, and amount of penicillin-binding proteins in Escherichia coli (1987)

A chromosomal region of Escherichia coli contiguous to the fabE gene at 71 min on the chromosomal map contains multiple genes that are responsible for determination of the rod shape and sensitivity to the amidinopenicillin mecillinam. The so-called mre region was cloned and analyzed by complementation of two closely related but distinct E. coli mutants characterized, respectively, by the mutations mre-129 and mre-678, that showed a rounded to irregular cell shape and altered sensitivities to mecillinam; the mre-129 mutant was supersensitive to mecillinam at 30 degrees C, but the mre-678 mutant was resistant. The mre-678 mutation also caused simultaneous overproduction of penicillin-binding proteins 1Bs and 3. A chromosomal region of the wild-type DNA containing the total mre region and the fabE gene was first cloned on a lambda phage; a 7-kilobase (kb) fragment containing the whole mre region, but not the fabE gene, was then recloned on a mini F plasmid, pLG339; and finally, a 2.8-kb fragment complementing only mre-129 was also cloned on this low-copy-number plasmid. The whole 7-kb fragment was required for complementing the mre-678 mutant phenotypes. Fragments containing fabE but not the mre-129 region could be cloned on a high-copy-number plasmid. Southern blot hybridization indicated that the mre-678 mutant had a large deletion of 5.25 kb in its DNA, covering at least part of the mre-129 gene.
Active Deformation Control for a Magnetically Levitated Planar Motor Mover (2021)

This article describes a method for the active control of the deformations on a magnetically levitated moving-magnet planar motor. The planar motor under consideration is comprised of a stator on a double coil array configuration and a mover with permanent magnets, and it is designed to perform positioning tasks with nanometer level of accuracy. Due to the spatially asymmetric, nonuniform force distribution on the magnet plate, mechanical deformations are induced to the mover, which can severely hinder the desired positioning accuracy. The proposed method overcomes this challenge by properly shaping the force distribution on the moving magnet plate, which is enabled by the presence of multiple coils interacting with the mover, corresponding to an &#x201C;overactuation&#x201D; scheme. As a consequence, the independent control of elementary deformation shapes (modes) is achieved. The proposed overactuation scheme is experimentally validated on a planar motor prototype, proving the efficiency of the proposed method during both standstill and motion.
Columbus: An Annotated Guide to the Scholarship on His Life and Writings, 1750 to 1988. (1993)

Journal Article Columbus: An Annotated Guide to the Scholarship on His Life and Writings, 1750 to 1988. By Foster Provost. (Detroit: Omnigraphics and Providence: John Carter Brown Library, 1991. xxxiv + 225 pp. $48.00, ISBN 1-55888-157-3.) and A Columbus Dictionary. By Foster Provost. (Detroit: Omnigraphics, 1991. xiv + 142 pp. $54.00, ISBN 1-55888-158-1.) Get access Carla Rahn Phillips Carla Rahn Phillips University of Minnesota, Twin Cities Search for other works by this author on: Oxford Academic Google Scholar Journal of American History, Volume 79, Issue 4, March 1993, Pages 1707–1708, https://doi.org/10.2307/2080374 Published: 01 March 1993
Mechanistic Study of a Pd/C‐Catalyzed Reduction of Aryl Sulfonates Using the Mg—MeOH—NH<sub>4</sub>OAc System. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A Woman's Guide to Sexual Health (2004)

Pick up the book that everyone is talking about: today's most invaluable resource guide for every woman who needs more time to talk with her doctor. Dr. Mary Jane Minkin, a gynecologist in practice for more than 25 years, has written the most up-to-date and readily accessible guide available for women wanting to know more than just what their hurried doctor's visit allows. This guide includes explanations of how exactly the body works, problems that may arise, and comprehensive solutions for women of all ages who are concerned with their reproductive health. An outstanding book...The authors write clearly and as though speaking directly to patients. Information is practical, based on current research, and never demeaning to women...Essential.--Choice A wonderful book about women's health issues of crucial importance to us all, particularly the young. While extremely informative, it is written with candor, wisdom, humor, and love. Perfect for my teenage daughter.--Valerie Harper
Multispectral Reconstruction From Reference Objects in the Scene (2019)

Hyperspectral imaging methods typically require dedicated cameras with extra optical elements (prisms, fibers, lenslet arrays), thus making them expensive and cumbersome to deploy. In this paper we explore a drastically different hyperspectral imaging approach, which requires no special optical components and can thus be used with any conventional camera. The idea is to place a reference object with a known spectrum (e.g. a black mask) within the field of view and to exploit the chromatic dependence of the Point Spread Function (PSF), in order to solve for the spectra of all other parts of the scene. We prove mathematically that chromatic-dependent blur cues alone are insufficient for fully recovering the spectrum of each pixel, even if the locations of edges in the (sharp) image are precisely known. Yet, we show that knowing the spectra at some of the pixels fully resolves this inherent ambiguity. We present an algorithm for solving the spectrum-from-reference inverse problem and illustrate its effectiveness through simulations as well as in a simple real world experiment.
Femtosecond laser-based nanosurgery reveals the endogenous regeneration of single Z-discs including physiological consequences for cardiomyocytes (2019)

A highly organized cytoskeleton architecture is the basis for continuous and controlled contraction in cardiomyocytes (CMs). Abnormalities in cytoskeletal elements, like the Z-disc, are linked to several diseases. It is challenging to reveal the mechanisms of CM failure, endogenous repair, or mechanical homeostasis on the scale of single cytoskeletal elements. Here, we used a femtosecond (fs) laser to ablate single Z-discs in human pluripotent stem cells (hPSC) -derived CMs (hPSC-CM) and neonatal rat CMs. We show, that CM viability was unaffected by the loss of a single Z-disc. Furthermore, more than 40% of neonatal rat and 68% of hPSC-CMs recovered the Z-disc loss within 24 h. Significant differences to control cells, after the Z-disc loss, in terms of cell perimeter, x- and y-expansion and calcium homeostasis were not found. Only 14 days in vitro old hPSC-CMs reacted with a significant decrease in cell area, x- and y-expansion 24 h past nanosurgery. This demonstrates that CMs can compensate the loss of a single Z-disc and recover a regular sarcomeric pattern during spontaneous contraction. It also highlights the significant potential of fs laser-based nanosurgery to physically micro manipulate CMs to investigate cytoskeletal functions and organization of single elements.