gebhart/patrepeval huggingface dataset:
High Energy Density in layered 2D Nanomaterial based Polymer Dielectric Films (2023)

Dielectric capacitors are critical components in electronics and energy storage devices. The polymer based dielectric capacitors have advantages of flexibility, fast charge and discharge, low loss, and graceful failure. Elevating the use of polymeric dielectric capacitors for advanced energy applications such as electric vehicles (EVs) however requires significant enhancement of their energy densities. Here, we report a polymer thin film heterostructure based capacitor of poly(vinylidene fluoride)/poly(methyl methacrylate) with stratified 2D nanofillers (Mica or h-BN nanosheets) (PVDF/PMMA-2D fillers/PVDF), that shows enhanced permittivity, high dielectric strength and an ultra-high energy density of 75 J/cm3 with efficiency over 79%. Density functional theory calculations verify the observed permittivity enhancement. This approach of using oriented 2D nanofillers based polymer heterostructure composites is expected to be universal for designing high energy density thin film polymeric dielectric capacitors for myriads of applications.
Development of theoretical models of integrated millimeter wave antennas (1991)

Extensive radiation patterns for Linear Tapered Slot Antenna (LTSA) Single Elements are presented. The directivity of LTSA elements is predicted correctly by taking the cross polarized pattern into account. A moment method program predicts radiation patterns for air LTSAs with excellent agreement with experimental data. A moment method program was also developed for the task LTSA Array Modeling. Computations performed with this program are in excellent agreement with published results for dipole and monopole arrays, and with waveguide simulator experiments, for more complicated structures. Empirical modeling of LTSA arrays demonstrated that the maximum theoretical element gain can be obtained. Formulations were also developed for calculating the aperture efficiency of LTSA arrays used in reflector systems. It was shown that LTSA arrays used in multibeam systems have a considerable advantage in terms of higher packing density, compared with waveguide feeds. Conversion loss of 10 dB was demonstrated at 35 GHz.
SafeSwab, a sample collection and dispensing device for near-patient testing (2021)

Abstract Background The COVID-19 pandemic has accelerated the pace of innovation around virtual care visits and testing technology. Here we present the SafeSwab (Safe Health Systems, Los Angeles, CA), an integrated, universal sample collection and dispensing device that is designed to minimize user error and enable rapid testing in a point of care or self-testing format. Methods The SafeSwab was used with the Safe Health Systems HealthCheck digital health application to enable self-testing by patients using lateral flow tests for SARS-CoV-2 antigen or for antibodies against SARS-CoV-2. Results Patients (n=74) using the SafeSwab produced a valid rapid test result in 96% of attempts, and 96% of patients felt confident that they had collected a good sample. The Safe HealthCheck app has an integrated image analysis algorithm, AutoAdapt LFA, that interprets a picture of a rapid test result, and the algorithm interpreted the result correctly 100% of the time. Conclusion The SafeSwab was found to be versatile and easy to use for both self-collected nasal sampling as well as fingerstick blood sampling. The use of Safe Health Systems HealthCheck app allows an integrated solution for patient instruction and test interpretation
20 Ideas for Teaching Gifted Kids in the Middle School and High School (2023)

Imagine taking your gifted and talented students to a mysterious old graveyard in town and teaching them to conduct history research using the information they gather, teaching gifted children the concepts behind great literature using modern science fiction, allowing your students to conduct independent research in their mathematics classroom, or encouraging your students to plan and participate in exotic travel around the world—without ever leaving your classroom.In this book, you will receive the best ideas and lessons for teachers of secondary gifted kids developed by master teachers across the nation. This exciting book features ideas for starting a mentorship program, teaching history using scientific surveys, using simulations to teach content, organizing historical debates, producing documentaries, and much more.20 Ideas features exciting activities and lessons such as: Be a Capitalist in Jolly Old England (an exciting activity for the world history classroom),Creative Thinking Skills in Mathematics (producing innovative ways to solve problems),Creating Simulations for the History Classroom (tips for using simulations with gifted students),Another Fine Mess . . . (building creative problem-solving activities that help teach subject area content), andmany more creative ideas and lessons.Bring some of the most innovative and inspirational lessons being offered today into your classroom with 20 Ideas.Grades 5-12
MEMS Compact Modeling Meets Model Order Reduction: Examples of the Application of Arnoldi Methods to Microsystem Devices (2004)

Modeling and simulation of the behavior of a system consisting of many single devices is an essential requirement for the reduction of design cycles in the development of microsystem applications. Analytic solutions for the describing partial differential equations of each component are only available for simple geometries. For complex geometries, either approximations or numerical methods can be used. However, the numerical treatment of the PDEs of thousands of interconnected single devices with each exhibiting a complex behavior is almost impossible without reduction of the order of unknowns to a lower-dimensional system. We present a fully automatic method to generate a compact model of second-order linear systems based on the Arnoldi process, and provide an example of successfull model order reduction to a gyroscope. Thus, the engineers need to simulate the system as a whole. By experience, they are able to define coupling effects between devices, which can be probed at certain terminals. For electrical devices, there is often a natural choice of these terminals, e.g. the emitter, collector and base of a bipolar transistor. However, e.g., for the temperature transport from a computer microchip, this choice is not so obvious. Once these terminals are identified, the microsystem can be partitioned into a number of devices and energy domains, each coupled by terminals.
Procedural sedation and analgesia in the emergency room of a field hospital after the Nepal earthquake (2016)

Procedural sedation and analgesia (PSA) should be a priority in the emergency care of injured children. This humanistic approach is particularly important in paediatric victims of disaster, because these patients are prone to psychological distress secondary to the traumatic event. Following the Nepal earthquake, an Israeli field hospital (IFH) was deployed in Kathmandu. We report our experience with PSA in the emergency room (ER) of the IFH. 22 children underwent surgery in the operating room and 10 underwent PSA in the ER by paediatric emergency physicians: 6 had wound debridement, 2 had fracture reduction and 2 had laceration repair. All the procedures were successfully completed in the ER and no patient required intubation or admission to the intensive care unit due to an adverse event. The present study is the first report of the practice of paediatric PSA by non-anaesthesiologists in a field hospital.
Design and Development of Effective Transmission Mechanisms on a Tendon Driven Hand Orthosis for Stroke Patients (2018)

Tendon-driven hand orthoses have advantages over exoskeletons with respect to wearability and safety because of their low-profile design and ability to fit a range of patients without requiring custom joint alignment. However, no existing study on a wearable tendon-driven hand orthosis for stroke patients presents evidence that such devices can overcome spasticity given repeated use and fatigue, or discusses transmission efficiency. In this study, we propose two designs that provide effective force transmission by increasing moment arms around finger joints. We evaluate the designs with geometric models and experiment using a 3D-printed artificial finger to find force and joint angle characteristics of the suggested structures. We also perform clinical tests with stroke patients to demonstrate the feasibility of the designs. The testing supports the hypothesis that the proposed designs efficiently elicit extension of the digits in patients with spasticity as compared to existing baselines.
Ambient Synthesis of High-Quality Ruthenium Nanowires and the Morphology-Dependent Electrocatalytic Performance of Platinum-Decorated Ruthenium Nanowires and Nanoparticles in the Methanol Oxidation Reaction (2013)

We report for the first time (a) the synthesis of elemental ruthenium nanowires (Ru NWs), (b) a method for modifying their surfaces with platinum (Pt), and (c) the morphology-dependent methanol oxidation reaction (MOR) performance of high-quality Pt-modified Ru NW electrocatalysts. The synthesis of our elemental Ru NWs has been accomplished utilizing a template-based method under ambient conditions. As-prepared Ru NWs are crystalline and elementally pure, maintain electrochemical properties analogous to elemental Ru, and can be generated with average diameters ranging from 44 to 280 nm. We rationally examine the morphology-dependent performance of the Ru NWs by comparison with commercial Ru nanoparticle (NP)/carbon (C) systems after decorating the surfaces of these structures with Pt. We have demonstrated that the deposition of Pt onto the Ru NWs (Pt~Ru NWs) results in a unique hierarchical structure, wherein the deposited Pt exists as discrete clusters on the surface. By contrast, we find that the Pt-decorated commercial Ru NP/C (Pt~Ru NP/C) results in the formation of an alloy-type NP. The Pt~Ru NPs (0.61 A/mg of Pt) possess nearly 2-fold higher Pt mass activity than analogous Pt~Ru NW electrocatalysts (0.36 A/mg of Pt). On the basis of a long-term durability test, it is apparent that both catalysts undergo significant declines in performance, potentially resulting from aggregation and ripening in the case of Pt~Ru NP/C and the effects of catalyst poisoning in the Pt~Ru NWs. At the conclusion of the test, both catalysts maintain comparable performance, despite a slightly enhanced performance in Pt~Ru NP/C. In addition, the measured mass-normalized MOR activity of the Pt~Ru NWs (0.36 A/mg of Pt) was significantly enhanced as compared with supported elemental Pt (Pt NP/C, 0.09 A/mg of Pt) and alloy-type PtRu (PtRu NP/C, 0.24 A/mg of Pt) NPs, both serving as commercial standards.
DNA-Binding Properties of Bis-<i>N</i>-substituted Tetrandrine Derivatives (2022)

A series of bis-<i>N</i>-substituted tetrandrine derivatives carrying different aromatic substituents attached to both nitrogen atoms of the natural alkaloid were studied with double-stranded model DNAs (dsDNAs) to examine the binding properties and mechanism. Variable-temperature molecular recognition studies using UV-vis and fluorescence techniques revealed the thermodynamic parameters, Δ<i>H</i>, Δ<i>S</i>, and Δ<i>G</i>, showing that the tetrandrine derivatives exhibit high affinity toward dsDNA (<i>K</i> ≈ 10<sup>5</sup>-10<sup>7</sup> M<sup>-1</sup>), particularly the bis(methyl)anthraquinone (BAqT) and bis(ethyl)indole compounds (BInT). Viscometry experiments, ethidium displacement assays, and molecular modeling studies enabled elucidation of the possible binding mode, indicating that the compounds exhibit a synergic interaction mode involving intercalation of one of the <i>N</i>-aryl substituents and interaction of the molecular skeleton in the major groove of the dsDNA. Cytotoxicity tests of the derivatives with tumor and nontumor cell lines demonstrated low cytotoxicity of these compounds, with the exception of the bis(methyl)pyrene (BPyrT) derivative, which is significantly more cytotoxic than the remaining derivatives, with IC<sub>50</sub> values against the LS-180, A-549, and ARPE-19 cell lines that are similar to natural tetrandrine. Finally, complementary electrochemical characterization studies unveiled good electrochemical stability of the compounds.
c-erbB-2 promoter-specific DNA-binding protein isolated from human breast cancer tissues displays mitogenic activity. (1994)

Amplification and overexpression of the c-erbB-2 gene appears to play a role in the pathogenesis of human breast and other cancers. Frequent amplification (20-30%) of the c-erbB-2 gene was observed in human adenocarcinomas of kidney, pancreas, lung, ovarian, and breast cancer. The gene product is a 185-kDa glycoprotein that has intrinsic tyrosine kinase activity and is believed to be a receptor. Several candidate ligands have been described. In the present study we have identified and purified a novel DNA-binding protein from malignant human breast tissues. The protein binds to a core element (-22 to +9, +1 being the transcription start site) of the c-erbB-2 promoter region in a sequence-specific manner. The affinity-purified protein has the ability to induce DNA synthesis in quiescent NIH/3T3 cells, suggesting that the factor has mitogenic activity. The purified protein induces c-erbB-2 expression on the surface of microinjected NIH/3T3 cells. This DNA-binding protein is a sequence-specific cellular factor that is associated with high level expression of the c-erbB-2 gene and appears to play a role in cell transformation. Understanding the control and expression of this DNA-binding protein may shed light on the mechanism(s) of c-erbB-2 gene regulation and its potential role in the pathogenesis of human adenocarcinomas.
Acquisition and Processing of 3-D Dual-Sensor Towed Marine Streamer Data (2010)

Traditionally, towed marine cables measure the seismic wavefield using only pressure sensors&lt;br&gt;(hydrophones). By contrast, in a dual-sensor streamer, independent measurements of the total&lt;br&gt;pressure and particle velocity wavefields are obtained using collocated sensors. These two&lt;br&gt;measurements of the seismic wavefield can be combined in processing to separate the wavefield into&lt;br&gt;up- and down-going components. 2-D case examples have demonstrated that this procedure is both&lt;br&gt;robust and accurate. This concept has now been extended to 3-D acquisition geometries. It has been&lt;br&gt;shown that 3-D dual-sensor streamer acquisition avoids exposure to weather, sea-state and streamer&lt;br&gt;spread control downtime by efficiently towing the entire 3-D streamer spread deep and at one common&lt;br&gt;depth. Removal of the receiver ghost effects simultaneously boosts both low and high frequencies&lt;br&gt;beyond any result achievable with conventional hydrophone-only streamers, and maximizes low&lt;br&gt;frequency signal-to-noise content required for accurate seismic inversion and reservoir description.&lt;br&gt;These applications are illustrated using data examples from a number of 3-D dual-sensor streamer surveys.
Periodically oscillating Anderson localization in random photonic superlattices with resonant units (2008)

In strongly disordered systems, where Anderson localization is present, the mean transmittance (<<i>T</i>>) decays exponentially on average with increasing sample size. However, <<i>T</i>> often shows large fluctuations originating from extremely rare occurrences of necklaces of resonantly coupled states, possessing almost unity transmission. We show in this study that in one-dimensional (1D) random photonic systems with resonant layers these fluctuations appear to be very regular and have a period defined by the localization length &xi; of the system. We demonstrate that necklace states are the origin of these well-defined oscillations. We predict that in such a random system efficient transmission channels form regularly each time the increasing sample length fits so-called optimal-order necklaces and demonstrate the phenomenon through numerical experiments. Our results provide new insight into the physics of Anderson localization in random systems with resonant units.
FLK-2/FLT-3 ligand regulates the growth of early myeloid progenitors isolated from human fetal liver (1995)

The effects of the recently identified FLK-2/FLT-3 ligand (FL) on the growth of purified human fetal liver progenitors were investigated under serum-deprived culture conditions. FL alone was found to stimulate modest proliferation in short-term cultures of CD34++ CD38+ lineage (Lin)- light-density fetal liver (LDFL) cells and the more primitive CD34++ CD38- Lin- LDFL cells. However, the low levels of growth induced by FL were insufficient for colony formation in clonal cultures. Synergism between FL and either granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin-3 (IL-3) or KIT ligand (KL) was observed in promoting the growth of high-proliferative potential (HPP) colony-forming cells (CF) and/or low-proliferative potential (LPP)-CFC in cultures of CD34++ CD38+ Lin- and CD34++ CD38- Lin- LDFL-cells. FL, alone or in combination with other cytokines, was not found to affect the growth of CD34+ Lin- LDFL cells, the most mature subpopulation of fetal liver progenitors investigated. The growth of the most primitive subset of progenitors studied, CD34++ CD38- Lin- LDFL cells, required the interactions of at least two cytokines, because only very low levels of growth were observed in response to either FL, GM-CSF, IL-3 or KL alone. However, the results of delayed cytokine-addition experiments suggested that individually these cytokines did promote the survival of this early population of progenitors. Although two-factor combinations of FL, KL, and GM-CSF were observed to promote the growth of early progenitors in a synergistic manner, neither of these factors was found to make fetal liver progenitors more responsive to suboptimal concentrations of a second cytokine. Only myeloid cells were recovered from liquid cultures of CD34++ CD38- Lin- LDFL cells grown in the presence of combinations of FL, KL, and GM-CSF. These results indicate that FL is part of a network of growth factors that regulate the growth and survival of early hematopoietic progenitors.
Rekombinantní enzym haloalkane dehalogenase HTS001 (2014)

Hydrolyticka halogenalkandehalogenasa HTS004 z Glaciecola
agarilytica NO2 s vysokou cistotou. Výsledek byl vyroben na
zakladě ověřeni vlastnosti.
Efficient through-waveguide wireless power transfer for body area networks (2017)

This paper focuses on a solution for wireless powering of sensor nodes embedded in an artificial “skin”, used to provide a sense of touch to persons using prosthetic limbs. The artificial “skin”, that consists of an inner dielectric layer with top and bottom soft metallization, acts as a waveguide, providing means to efficiently guide electromagnetic power to sensor nodes. The proposed solution allows removal of wired connections between soft metallization layers and sensor nodes, that are identified as the primary source of failure. Depending on node distances and propagation conditions, measurements indicate that the available power at the receiving node ranges from 46.8 % to 66.1 % of the transmitted power. Lower efficiency, compared to wired powering, is thus traded for higher reliability and reduced production cost.
Gold(I)‐Catalyzed Synthesis of Functionalized Cyclopentadienes. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
A mathematical model of endothelium‐smooth muscle interaction in regulating microcirculatory tone (2006)

In the vascular wall coupling between endothelial (EC) and smooth muscle (SMC) cells generates complex feedback control loops that regulate arteriolar diameter and blood flow. Ample experimental studies investigate signaling pathways involved in the regulation of vascular tone, but there are far less theoretical studies to assist in the analysis of experimental data. We developed biophysical models of Ca 2+ dynamics in EC and SMC of the rat mesenteric microcirculation that incorporate NO dependent signaling. Isolated single cell models were validated against experimental data and then integrated through myoendothelial gap junctions and NO diffusion. Stimulation of SMC with extracellular K + or norepinephrine (NE) evokes Ca 2+ oscillations if the resulting increase in intracellular concentration ([Ca 2+ ]i) falls within the 200–300nM range. EC stimulation in NE‐preconstricted vessels repolarizes SMC and reduces [Ca 2+ ]i by 1) transmitting a hyperpolarizing current through the gap junctions and/or 2) by NO‐induced activation of SM KCa channels. IP3 coupling was necessary for transmitting information from SM to EC and generates negative feedback loops capable of reducing NE‐induced SM [Ca 2+ ]i transients. Partial Na + −K + pump inhibition, simulating effect of ouabain in salt sensitive hypertension, caused Na + accumulation, Na + −Ca 2+ exchanger reversal, hyperreactivity to NE and SM desensitization to NO. The model reproduces a variety of experimental findings and proposes testable hypothesis for optimal NO delivery strategies. Supported by AHA grant NSDG043506N.
Introducing reliability and real-time features in flexible agent-oriented automation systems (2005)

By means of agent oriented software engineering, flexible, adaptive automation systems can be developed. An open question is, nevertheless, how could the specific requirements on automation systems, in particular related to dependability and real-time features, be considered. In This work an approach for the integration of such features in the development of flexible agent oriented automation systems is presented.
Spatial characteristics of topography, energy exchange, and forest cover in a central Appalachian watershed (1995)

Spatial variation of topography, net radiation, evapotranspiration, and forest stand in the central Appalachian watershed is described, The study area is the control watershed 4 (3920'N,7949W) located in the Fernow Experimental Forest at Parsons, West Virginia. The watershed encompasses an area of 39.2 ha, it has a southeast orientation, and the average slope inclination is 14. The forest cover is ca. 85 years old and consists of upland oak and cove hardwoods. Topographic analysis was based on data for 432 triangular segments with an average area of 360 m2, covering the whole watershed. Partial areas for defined slope and azimuth ranges and the distribution of both parameters are illustrated, Half of the watershed area has an azimuth between 90 and 150 (east facing slopes), and 65% of the area has slope inclination ranging from 10 to 20. Net radiation (Rn) was computed for all terrain segments. Its distribution in the watershed is illustrated, and its average yearly sum for the whole watershed was 2.2 GJ m-'. Yearly sum of Rn of southwest facing slopes was 55% (lower sites) to 60% (upper sites) greater than that of east facing slopes. The average yearly precipitation (P) and evapotranspiration (Et) of the watershed are 145.5 cm and 81.7 cm, respectively. A regression formula f yearly Et of partial areas varied from ca. 60 to 85 cm. The average air-dry above ground biomass for 112 plots was 320.3 t ha-'. East facing slopes had the highest air-dry biomass (354 t hd1) and the southwest facing slopes the lowest (224 t has1). Thirty-five species were recorded on the plots surveyed. The most frequent species were sugar maple (32.1% of the total number of trees, DBH > 5 cm), red maple (19.3%), American beech (9.7%), northern red oak (7.6%). black cherry (4.1%), sweet birch (3.6%), and chestnut oak (2.4%). Red oak had the highest total biomass (30.2% of the total for all species), followed by sugar maple (13.8%), black cherry (13.0%), red maple (9.9%), chestnut oak (6.9%), yellow-poplar (5.7%), American beech (4.7%), and white oak (4.5%).