gebhart/patrepeval huggingface dataset:
Erythropoietin ameliorates chemotherapy‐induced fibrosis of the lungs in a preclinical murine model (2008)

Organ toxicity induced by chemotherapeutic drugs is a serious obstacle in the effective treatment of patients suffering from cancer and autoimmune disease. A strong association exists between pulmonary toxicity, particularly fibrosis, and chemotherapeutic drugs. Attempts have been made to identify compounds capable of suppressing fibrosis. In addition to its erythropoietic activity, erythropoietin (EPO) has been shown to have effects on nonhemopoietic cells. Therefore, we postulated that EPO may exert beneficial effects on lung tissue during chemotherapy. To test our hypothesis, we investigated pulmonary changes caused by bleomycin, a fibrosis-inducing agent, in animals treated with the drug alone and in combination with EPO. Fibrosis, cellular alterations and structural changes were assayed by blind analysis of the lung sections. A 6-fold decrease in the number of prominent endothelial cells--suspected to be indicative of cellular activation and inflammatory response--was observed in lung sections derived from mice treated with bleomycin and EPO compared to animals injected with bleomycin alone (p < 0.008). Additionally, there was twice the number of ICAM1-positive endothelial cells in animals treated with bleomycin alone compared with the number in the bleomycin and EPO-treated group (p < 0.05). Alveolar mononuclear phagocytic hyperplasia was reduced by as much as 100% in animals treated with bleomycin and EPO compared to animals treated with bleomycin alone (p < 0.03). Finally, a 5-fold decrease in interstitial fibrosis was observed in lung sections obtained from animals treated with bleomycin and EPO (p < 0.02). We conclude that EPO can ameliorate drug-induced fibrosis and endothelial damage caused by chemotherapeutic agents.
Tear Strength of Four Irreversible Hydrocolloid Impression Materials (1998)

Tare-Free Alg had the highest tear strength value, followed by Jeltrate, Identic, and Kromopan.
The numerical study on performance evaluation of a thermal switch capacitor in a magnetocaloric cooling device (2022)

Compact, solid thermal control devices offer a new way to control the intensity and direction of heat flow between the components of a system, which is crucial for both optimized performance and safety. In this work we study a thin, silicon thermal switch capacitor (TSC) used for heat transport in a magnetocaloric cooling system. A numerical model was developed to quantify the effects of various operating conditions and design parameters on the performance of a magnetocaloric device with an embedded TSC. Based on realistic material properties, a maximum cooling-power density of 4000 Wm<sup>-2</sup> (2025 <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow><mml:msubsup><mml:mtext>Wkg</mml:mtext> <mml:mrow><mml:mi>m</mml:mi> <mml:mi>c</mml:mi> <mml:mi>m</mml:mi></mml:mrow> <mml:mrow><mml:mo>-</mml:mo> <mml:mn>1</mml:mn></mml:mrow> </mml:msubsup> </mml:mrow> </mml:math> ) was obtained for a zero temperature span and an operating frequency of 20 Hz. The use of the presented device was demonstrated on a battery system, motivating further experimental studies to develop a new, compact cooling device that can be directly attached to a heat reservoir, making it desirable for a variety of applications.
Delayed symptomatic intracerebral hemorrhages in neuro-Behcet’s disease (2016)

Central nervous system involvement occurs in 10-30% of Behcet's disease (BD). Although its symptoms gradually resolve without leaving significant sequelae in most cases, neurologic involvement of BD (NBD) can have progressive courses in some occasions, which are associated with poor neurologic prognosis and warrant stepping up the immunemodulating treatment However, we experienced a rare case of NBD which had a neurologic aggravation at subacute stages accompanied with delayed development of hemorrhages, which mimicked a true progression of disease.
Metallic Inverse Opal Frameworks as Catalyst Supports for High‐Performance Water Electrooxidation (2022)

High intrinsic activity of oxygen evolution reaction (OER) catalysts is often limited by their low electrical conductivity. To address this, we introduce copper inverse opal (IO) frameworks offering a well-developed network of interconnected pores as highly conductive high-surface-area supports for thin catalytic coatings, for example, the extremely active but poorly conducting nickel-iron layered double hydroxides (NiFe LDH). Such composites exhibit significantly higher OER activity in 1 m KOH than NiFe LDH supported on a flat substrate or deposited as inverse opals. The NiFe LDH/Cu IO catalyst enables oxygen evolution rates of 100 mA cm<sup>-2</sup> (727±4 A g<sub>catalyst</sub> <sup>-1</sup> ) at an overpotential of 0.305±0.003 V with a Tafel slope of 0.044±0.002 V dec<sup>-1</sup> . This high performance is achieved with 2.2±0.4 μm catalyst layers, suggesting compatibility of the inverse-opal-supported catalysts with membrane electrolyzers, in contrast to similarly performing 10<sup>3</sup> -fold thicker electrodes based on foams and other substrates.
Lipoxygenase catalyzed oxygenation of lipids (1998)

Lipoxygenases (LOXs) and other LOX pathway enzymes are potentially able to form a large set of compounds being of commercial interest. Among them are conjugated dienic acids, jasmonates, and volatile aldehydes. Additionally, fatty acid hydroperoxides, formed by LOX, can serve as precursors for further transformation by either enzymes of the so-called LOX pathway or by chemical reactions. In the case of linoleic acid more than one hundred products generated from its LOX-derived fatty acid hydroperoxides have been described. Many of these products exhibit biological activity, suggesting a significant biological function of LOXs. This will be described for two different 13-LOXs. (I) In various oilseeds we found that specific 13-LOXs are localized at the lipid body membrane. They are capable of oxygenating esterified polyenoic fatty acids, such as triacylglycerols and phospho-lipids. In addition, they form with arachidonic acid as substrate preferentially either 8- or 11-hydroperoxy eicosatetraenoic acid, which is a very unusual positional specificity for plant LOXs. (II) From barley leaves we isolated another linoleate 13-LOX form, which is localized within chloroplasts and is induced by jasmonic acid methyl ester. It is suggested, that this LOX form is capable of oxygenating linolenic acid residues of galactolipids. Examples will be presented for barley leaves of oxygenated derivatives of linolenic acid and compounds resulting from the hydroperoxide lyase-branch of the LOX pathway. Lipoxygenase-katalysierte Oxygenierung von Lipiden Lipoxygenasen (LOXs) und andere Enzyme des LOX-Reaktionsweges verfügen über die Fähigkeit, die Synthese einer Vielzahl von Verbindungen zu katalysieren, die von kommerziellem Interesse sind. Zu diesen Verbindungen zählen konjugierte Dienfettsäuren, Jasmonate und Aldehyde. Zusätzlich sind Fettsäurehydroperoxide, die von LOXs gebildet werden, Substrate mehrerer Enzyme des LOX-Reaktionsweges oder Ausgangspunkt chemischer Umsetzungen. Allein für Linolsäure sind mehr als hundert Produkte beschrieben worden, die aus der Umsetzung mit ihren Hydroperoxiden stammen. Viele dieser Verbindungen besitzen biologische Aktivität. Dies deutet auf eine signifikante biologische Funktion von LOXs hin. Hier wird dies für zwei verschiedene 13-LOX-Formen erläutert. (I) In einer Vielzahl von Ölsaaten konnte eine spezifische 13-LOX an der Membran von Lipidkörpern lokalisiert werden. Sie kann veresterte Polyenfettsäuren in Triacylglyceriden und Phospholipiden oxygenieren. Zusätzlich wird bei der Umsetzung von Arachidonsäure die bevorzugte Bildung von 8- oder 11-Hydroperoxyeicosatetraensäure beobachtet. Dies stellt für pflanzliche LOXs eine ungewöhnliche Produktspezifität dar. (II) Aus Gerstenblättern wurde eine weitere 13-LOX isoliert, die in den Chloroplasten lokalisiert ist und durch Methyljasmonat induziert wird. Diese LOX-Form scheint die Linolensäurereste von Galaktolipiden umsetzen zu können. Hierfür spricht der Nachweis von oxygenierten Linolensäurederivaten und Verbindungen, die aus dem Lyasezweig des LOX-Reaktionsweges resultieren.
The Clash of Territorialities. (2018)

Der Aufsatz untersucht die sich überlagernden Territorialisierungsmuster in der Finnisch-Russischen Grenzregion. Dabei wird den Friktionen zwischen diesen verschiedenen Mustern im Rahmen von EU-Politiken vor dem Hintergrund sich wandelnder historischer Formen supranationaler, nationaler und regionaler Territorialisierung besondere Aufmerksamkeit gewidmet. Das Fallbeispiel Karelien stand als historische Region für mehr als tausend Jahre im Zentrum von Auseinandersetzungen rivalisierender Projekte der Staats- und Nationenbildung im europäischen Norden. Der Aufsatz untersucht u. a., welche Rolle dieses historische Erbe in der Regionalpolitik der Europäischen Union spielt und in welcher Form es in heutigen supra-nationalen, nationalen und regionalen Vorstellungen von grenzüberschreitender Regionalisierung präsent ist. Karelien kann als Paradebeispiel für das Aufeinandertreffen verschiedener Formen der Regionalisierung, der Staatsbildung wie auch der Definition der Ost-West-Konfrontation gelten. Seine Territorialisierungsmuster haben immer auch die Machtverschiebungen innerhalb des europäischen Staatensystems reflektiert. Das historische Erbe der Region umfasst seit seiner doppelten imperialen Vergangenheit bis nach dem Kalten Krieg verschiedene Formen der Bestimmung dieser räumlichen Einheit: als regionale Gemeinschaft mit eigenen ethnischen, sprachlichen und religiösen Besonderheiten; als Grenzland, das von rivalisierenden Staaten und sich überlagernden nationalisierenden Ansprüchen geteilt wird; und schließlich als Berührungspunkt und Trennlinie zwischen Ost und West. Das Ende des Kalten Krieges und die Effekte der EU-Regionalpolitik brachten neue Formen der marktorientierten Regionalisierung hervor, wobei die EU die verschiedenen territorialen Ebenen hierarchisch organisierte und in hohem Maße die wechselseitigen historischen Verbindungen, Brüche und Konflikte ignorierte. Nach dem Zusammenbruch der Sowjetunion, der Einführung der EU-Regionalpolitik, einschließlich der neuen Nachbarschaftspolitik, und der Einrichtung der Euroregion Karelien im Jahr 2000 entstanden neue Formen des Austauschs in der Grenzregion. Grenzüberschreitende Kooperation, maßgeblich geprägt durch die Verlagerung des Schwerpunkts weg von einer nationalstaatlich dominierten Außenpolitik hin zu Mehrebenenstrukturen und -netzwerken die von unabhängigen Akteuren gebildet werden, hat die Rolle der mittleren Ebene gestärkt. Die Ziele der impulsgebenden Akteure dieser grenzüberschreitenden Praktiken waren dabei nicht auf die Herausbildung eines regionalen Grenzregimes begrenzt, sondern berührten auch zentrale Fragen europäischer und nationaler Identitätspolitik. Der Aufsatz plädiert für die Anerkennung der historischen und politischen Wechselbeziehungen, Brüche und Konflikte zwischen unterschiedlichen Verständnissen der territorialen Bezüge und unterstreicht die Notwendigkeit komparativer Studien zur politischen Sprache der grenzüberschreitenden Kooperation.
Prevalence of Plasmodium falciparum infection in pregnant Cameroonian women. (2002)

Between 1995 and 1998, a longitudinal study was conducted at 2 health centers in Cameroon to determine the prevalence of Plasmodium falciparum infection in pregnant women. There were 520 pregnant women enrolled at a rural clinic in the village of Etoa and 199 enrolled at the Biyem Assi Clinic in the city of Yaounde. In Etoa, pregnant women were younger, fewer took prophylaxis, and malaria prevalence was higher compared with pregnant women in the Biyem Assi Clinic. The prevalence of malaria infection peaked during the fourth month of pregnancy at both sites. Age was identified as a major risk factor because women < or = 20 years old were 1.8 and 3.4 times more likely to have malaria infection than women > 20 years old at Etoa and the Biyem Assi Clinic after adjusting for gravidae and other factors. The use of chemoprophylaxis and seasonality did not have a major effect.
Structure of a Synthetic Glucose Derived Advanced Glycation End Product That Is Immunologically Cross-Reactive with Its Naturally Occurring Counterparts (1999)

Glucose reacts nonenzymatically with the amino groups of proteins to form stable, cross-linking adducts called advanced glycation end products or AGEs. While several lines of evidence have established that AGEs accumulate in tissues and contribute to the pathological sequelae of diabetes and aging, the identity of the major cross-link(s) that forms in vivo has remained enigmatic. This has been considered to be due to the labile nature and to the low fluorescence properties of this cross-link, despite the fact that fluorescence has been generally associated with AGE formation in vivo. Accordingly, the few AGE adducts that have been isolated thus far from proteins in vivo or from model systems in vitro have been found to account for only a fraction of the glucose-derived cross-links that occur in tissues. This situation has been further underscored by the development of a well-characterized class of antibodies that recognize in vivo AGEs but which fail to react with the structurally defined AGEs that have been identified to date. This particular class of anti-AGE antibodies has proven valuable in the quantification of AGE-modified forms of hemoglobin, low-density lipoprotein (LDL), and beta-amyloid peptide, and can provide prognostic information on the course of certain diabetic complications. To obtain insight into the structure of this immunoreactive, AGE adduct, we used an anti-AGE antibody (RU) as a probe to isolate novel AGE(s) that formed within a reaction mixture of glucose and the model glycation substrate, N(alpha)-CBZ-Arg-Lys. HPLC purification of an immunoreactive fraction that accumulated in this preparation showed the presence of a compound that was determined by (1)H NMR and electrospray ionization mass spectrometry (ESI-MS) to be a stable, imidazole-based cross-link (termed arginine-lysine imidazole or ALI). The properties of ALI, immunoreactivity, acid-lability, nonfluorescence, and inhibition of formation by aminoguanidine, suggest that ALI is likely to typify an important class of the AGE cross-links that form in vivo.
Superior Capsular Reconstruction for the Operatively Irreparable Rotator Cuff Tear: Clinical Outcomes Are Maintained 2 Years After Surgery (2019)

IV retrospective case series.
Integrative QTL analysis of gene expression and chromatin accessibility identifies multi-tissue patterns of genetic regulation (2020)

Gene transcription profiles across tissues are largely defined by the activity of regulatory elements, most of which correspond to regions of accessible chromatin. Regulatory element activity is in turn modulated by genetic variation, resulting in variable transcription rates across individuals. The interplay of these factors, however, is poorly understood. Here we characterize expression and chromatin state dynamics across three tissues-liver, lung, and kidney-in 47 strains of the Collaborative Cross (CC) mouse population, examining the regulation of these dynamics by expression quantitative trait loci (eQTL) and chromatin QTL (cQTL). QTL whose allelic effects were consistent across tissues were detected for 1,101 genes and 133 chromatin regions. Also detected were eQTL and cQTL whose allelic effects differed across tissues, including local-eQTL for Pik3c2g detected in all three tissues but with distinct allelic effects. Leveraging overlapping measurements of gene expression and chromatin accessibility on the same mice from multiple tissues, we used mediation analysis to identify chromatin and gene expression intermediates of eQTL effects. Based on QTL and mediation analyses over multiple tissues, we propose a causal model for the distal genetic regulation of Akr1e1, a gene involved in glycogen metabolism, through the zinc finger transcription factor Zfp985 and chromatin intermediates. This analysis demonstrates the complexity of transcriptional and chromatin dynamics and their regulation over multiple tissues, as well as the value of the CC and related genetic resource populations for identifying specific regulatory mechanisms within cells and tissues.
On discrete assembly process modeling method based on event-driven strategy (2008)

Discrete assembly production process modeling is one of the difficult problems in discrete manufacturing enterprise modeling. This paper presents an event-driven discrete assembly process model. The key idea of model is to define several meta-events according to the characteristics of assembly process. Real activities of assembly process are transformed into event sets extended by meta-events. The whole assembly process can be described by combinations of events. Then modeling of complex production is achieved. Because of this model, status of the assembly process can be monitored. When some abnormal events appear, the system can respond in time. The smooth running of the assembly process is guaranteed.
Data from POSEIDON Trial Phase 1b Results: Safety, Efficacy and Circulating Tumor DNA Response of the Beta Isoform-Sparing PI3K Inhibitor Taselisib (GDC-0032) Combined with Tamoxifen in Hormone Receptor Positive Metastatic Breast Cancer Patients (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;The strategy of combining endocrine therapy with PI3K-mTOR inhibition has shown promise in estrogen receptor (ER)–positive breast cancer, but new agents and combinations with a better therapeutic index are urgently needed. Taselisib is a potent, selective, beta-isoform–sparing PI3 kinase inhibitor.&lt;/p&gt;Patients and Methods:&lt;p&gt;30 patients with ER-positive, metastatic breast cancer who had failed prior endocrine therapy were treated with escalating doses of taselisib (2 or 4 mg in an intermittent or continuous schedule) combined with tamoxifen 20 mg once daily in this phase 1b study using a “rolling six” design.&lt;/p&gt;Results:&lt;p&gt;Taselisib combined with tamoxifen was generally well tolerated, with treatment-emergent adverse events as expected for this class of drugs, including diarrhea (13 patients, 43%), mucositis (10 patients, 33%), and hyperglycemia (8 patients, 27%). No dose-limiting toxicities were observed. Objective responses were seen in 6 of 25 patients with RECIST-measurable disease (ORR 24%). Median time to disease progression was 3.7 months. Twelve of 30 patients (40%) had disease control for 6 months or more. Circulating tumor (ct)DNA studies using next-generation tagged amplicon sequencing identified early indications of treatment response and mechanistically relevant correlates of clinical drug resistance (e.g., mutations in &lt;i&gt;KRAS, ERBB2&lt;/i&gt;) in some patients.&lt;/p&gt;Conclusions:&lt;p&gt;Taselisib can be safely combined with tamoxifen at the recommended phase 2 dose of 4 mg given once daily on a continuous schedule. Preliminary evidence of antitumor activity was seen in both &lt;i&gt;PIK3CA&lt;/i&gt; mutant and wild-type cancers. The randomized phase 2 part of POSEIDON (testing tamoxifen plus taselisib or placebo) is currently recruiting.&lt;/p&gt;&lt;/div&gt;
Activation of ribosomal protein S2 gene expression in a hamster model of chemically induced oral carcinogenesis (1993)

7,12-Dimethylbenz[a]anthracene (DMBA)-induced carcinogenesis of the hamster buccal pouch has been an excellent model for the study of squamous cell carcinogenesis in human head and neck cancer. Using a differential hybridization of cDNA cloning technique, we isolated a cDNA clone that is expressed in N-ras-transformed PA-1 cells but poorly expressed in non-tumorigenic PA-1 cells; the cDNA codes for the human ribosomal S2 gene product. To define the involvement of S2 gene expression during carcinogenesis in this animal model, we used in situ hybridization technique with non-radioactive digoxigenin-11-dUTP-labeled cDNA. S2 gene was expressed at low levels in basal and suprabasal cell layers of the epidermis in the control, but showed marked elevation throughout the epidermis other than the keratin layer in samples treated for 4 or 8 weeks; S2 was highly expressed in all malignant squamous cell carcinoma cells resulting from DMBA treatment for 16 weeks. As tumors progress from normal epithelium to squamous cell carcinomas, mRNA of the S2 gene was not only elevated sequentially, but also demonstrated the marked heterogeneity among transformed populations, particularly in dysplastic lesions and squamous cell carcinomas. The S2 gene was expressed in a stage-specific manner in the hamster tumor model; S2 could be useful as a neoplastic marker for the detection of certain epithelial origin of tumors and premalignant lesions as well.
Demonstration of C/S based hardware accelerated QoT estimation tool in dynamic impairment-aware optical network (2010)

An enhanced version of hardware accelerated QoT estimation tool in impairment-aware optical network is demonstrated and evaluated against the different number of lightpaths and wavelengths per link. It outperforms the software version by 28 times in the order of millisecond.
Training a prosody-based dialog act tagger from unlabeled data (2003)

Dialog act tagging is an important step toward speech understanding, yet training such taggers usually requires large amounts of data labeled by linguistic experts. Here we investigate the use of unlabeled data for training HMM-based dialog act taggers. Three techniques are shown to be effective for bootstrapping a tagger from very small amounts of labeled data: iterative relabeling and retraining on unlabeled data; a dialog grammar to model dialog act context, and a model of the prosodic correlates of dialog acts. On the SPINE dialog corpus, the combined use of prosodic information and unlabeled data reduces the tagging error between 12% and 16%, compared to baseline systems using word information and various amounts of labeled data only.
Dynamic holographic memory showing readout, refreshing, and updating capabilities (1992)

We propose a new refreshing procedure for reading out a dynamic holographic memory without loss of information. The retrieved images are fed back to the memory after being thresholded and amplified. Experimental demonstration is performed with a LiNbO(3) photorefractive crystal.
Development of α/γ Transformable FeCrAl-ODS Alloys by Nickel Addition (2019)

Utilizing γ/α transformation allows for a wider range of structure control for Al2O3-forming FeCrAl alloys considered as a candidate for the advanced fast reactor fuel cladding. In this research, nickel addition was explored as a method for creating γ-austenite at 1000°C and retaining α-ferrite at room temperature through computing phase diagram by FactSage and implementing HT-XRD & EPMA experiments. In addition, Al2O3 scale formation by oxidation test was implemented at 1000°C. Those results indicated that structure control by the γ/α transformation is realized with appropriate aluminum and nickel addition, keeping continuous Al2O3 scale formation.