gebhart/patrepeval huggingface dataset:
Flying watch: an attachable strength enhancement device for long-reach robotic arms (2019)

A long-reach robotic arm is useful for applications such as nuclear plant decommissioning, inspection, and firefighting. However, for such arms, a small external reaction force can result in large loads on proximal arm actuators because of long moment arms. This problem was previously solved by specialized arm designs that compensate external reaction forces. However, these arm designs are hard to be applied to other arms or customized to different missions. To overcome these difficulties, in this paper, we propose a modular thrust generating concept inspired by wristwatch designs, called flying watch, which can be attached to a robotic arm with mission-dependent attachment styles (attachment positions and orientations) and cooperate with actuators to enhance arm strength. We first introduce flying watch concept, design, and dynamics. Then we propose two levels of watch-actuator cooperation in quasistatic situations by introducing a problem called Watch Actuator Cooperation for Arm Enhancement (WACAE) and providing an example solution. The first level of cooperation is only watches adapt their thrusts to minimize actuator loads, which is generally applicable to varieties of arms. The second level cooperation is that not only do the watches adapt their thrusts but also the actuators cooperatively position the watches to optimal positions and orientations to counteract external reaction forces, which is suitable for redundant arms and can counteract external reaction forces more effectively. Finally, we present simulations to verify that flying watches can significantly reduce actuator loads using both levels of watch-actuator cooperation (the first level by 36.9% and the second level by 43.7%).
The Power of Many: Enhancing Photographs with Multiple Images (2015)

Multiple images are routinely used to improve imaging performance in both incoherent and coherent imaging systems. We will discuss some recent algorithmic advances and the applications they enable. Article not available.
Supplementary Figure 1 from Expression Profile of BCL-2, BCL-X&lt;sub&gt;L&lt;/sub&gt;, and MCL-1 Predicts Pharmacological Response to the BCL-2 Selective Antagonist Venetoclax in Multiple Myeloma Models (2023)

&lt;p&gt;Disruption of BCL-2-BIM complexes in venetoclax-sensitive HMCLs&lt;/p&gt;
Characterization Of A Charge-Injection-Device Camera System As A Multichannel Spectroscopic Detector (1987)

A solid-state camera system designed for use as a multichannel detection system for spectroscopic applications is evaluated. The camera is based on a charge-injection-device sensor that permits very high dynamic range operation by virtue of its unique nondestructive readout capability. Methods of determining gain and readout noise are discussed. Performance of the camera system is evaluated with respect to sensitivity, linearity, readout noise, and dynamic range. The use of nondestructive readout to reduce effective readout noise and increase dynamic range is described. Spectral responses in the visible and ultraviolet of coronene-coated and uncoated devices are reported. Various time-dependent anomalies caused by interface trapped charge are discussed.
Augmented ICOS expression in patients with early diffuse cutaneous systemic sclerosis (2012)

Augmented ICOS signalling may contribute to the pathogenesis of SSc during early progressive disease. Soluble ICOS levels may be used as a serum marker for the activity and severity of SSc.
Supplementary Figure S5 from HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization (2023)

&lt;p&gt;Supplementary Figure S5. PRKD2 overexpression restores tumor viability and vascularization formation in nude mice treated with PU-H71.&lt;/p&gt;
Lessons Learned From Twenty-Eight Cases of Burns Following Breast Reconstruction: An Underestimated Complication Requiring Inclusion in Consent Information (2021)

Abstract Background There has over recent years been a constant increase in annual breast reconstruction figures. Although reports indicate that burns following breast reconstruction are a rare occurrence, there has nevertheless been a relative increase in cases. The key underlying causes of this type of condition remain unknown. Objectives The authors launched a new study on the demographic characteristics of burns in the breast reconstruction population with the inclusion of up-to-date data to assess cases and contributing factors. Methods The study was a multicenter retrospective review of patients who underwent any type of breast reconstruction and subsequently sustained burn injuries. Results Twenty-eight cases of burn injury following breast reconstruction were documented; 6 involved autologous flaps and 22 involved implants. Nine of the 10 implant exposure cases had previous history of radiotherapy, but there was no statistically significant difference between previous radiotherapy history and implant exposure (P = 0.32). Of the 13 cases sustaining full-thickness burns, a large number included implant-based reconstruction (n = 12, 92%), although no statistically significant difference was observed between type of reconstruction and incidence of full-thickness burns (P = 0.17). Conclusions Each patient undergoing breast reconstruction should be advised of the potential risks and instructed to avoid significant heat exposure and steer clear of dark-colored bathing suits. At the time of writing, this information has yet to be included in the vast majority of surgery-related informed consent documents. Level of Evidence: 4
Enantiopure Laterally Functionalized Alleno–Acetylenic Macrocycles: Synthesis, Chiroptical Properties, and Self‐Assembly in Aqueous Media (2014)

A family of shape-persistent alleno-acetylenic macrocycles (SPAAMs), peripherally decorated with structurally diverse pendant groups, has been synthesized and characterized in enantiomerically pure form. Their electronic circular dichroism (ECD) spectra feature a strong chiroptical response, which is more than two times higher than for open-chain tetrameric analogues. A water-soluble oligo(ethylene glycol)-appended SPAAM undergoes self-assembly in aqueous solution. Morphology studies by cryogenic transmission electron microscopy (cryo-TEM) revealed the formation of aggregates with fibrous fine structures that correspond to tubular, macrocyclic stacks.
New Vaccines for Developing Countries: Will it Be Feast or Famine? (2009)

The Revolving Fund of the Pan American Health Organization (PAHO) has an almost 30 year track record of providing access to essential vaccines for the entire population of Latin America and the Caribbean region. The activities of the PAHO Revolving Fund, coupled with the provision of high-quality technical assistance, were crucial to the successful control, elimination, or eradication of most of the region's great childhood killers, including measles and polio. Today, however, the Revolving Fund faces new challenges in the form of procuring a new generation of vaccines for human papillomavirus infection, rotavirus, and pneumococcal disease, which are priced orders of magnitude higher than the traditional childhood vaccines. The high cost of these essential new vaccines may require the PAHO Revolving Fund to establish innovative financial mechanisms for procuring these products at prices affordable for national immunization programs in Latin America and the Caribbean. The alternative, namely to bypass the Revolving Fund, could severely threaten the health of the region, especially Latin America's poorest people.
Optimization of Multiple Bit Runs Based on ROP Models and Cost Equation: A New Methodology Applied for One of the Persian Gulf Carbonate Fields (2008)

Abstract Improving the rate of penetration (ROP) is one of the key methods to reduce drilling costs. Several ROP models have been developed and modified based on the concept where unconfined compressive strength (UCS) is inversionally proportional with the rate of penetration. These models can predict the rate of penetration of different bit types in an oil or gas field with a reasonable degree of accuracy. The ROP model studied herein relates the rate of penetration to operating conditions and bit parameters in addition to the rock strength. Also, the effects of bit hydraulics and bit wear on rate of penetration are included in the model. In this paper, the drilling performance was optimized, using the ROP models, for upcoming wells in one of the Persian Gulf carbonate fields. Based on previous drilled wells a rock strength log along the wellbore is created and modified to mach the the new well survey. The rock strength is back calculated from the ROP model which includes bit design and reported field wear in conjunction with meter by meter operating parameters, formation lithologies and pore pressure. By conducting a number of simulations a learning curve was constructed to obtain the optimum bit hydraulics, best combination of operational parameters and the most effective bit design. Based on the proposed ROP model, a simple and useful simulator was developed. This methodology can be used in pre-planning and post analysis to reduce drilling cost where previously drilled wells exist.
Preferential Orientation in Hematite Films for Solar Hydrogen Production via Water Splitting (2010)

The state-of-the-art performance, obtained through the reduction of precursor gas residence time in hematite photoanodes produced by APCVD, is explained in this report by an enhanced preferential orientation of the highly conductive crystal planes perpendicular to the electron-collecting substrate.
Generation of iPSC-Derived Human Peripheral Sensory Neurons Releasing Substance P Elicited by TRPV1 Agonists (2018)

Neural crest stem cells (NCPCs) have been shown to differentiate into various cell types and tissues during embryonic development, including sensory neurons. The few studies addressing the generation of NCPCs and peripheral sensory neurons (PSNs) from human induced pluripotent stem cells (hiPSCs), generated sensory cells without displaying robust activity. Here, we describe an efficient strategy for hiPSCs differentiation into NCPCs and functional PSNs using chemically defined media and factors to achieve efficient differentiation, confirmed by the expression of specific markers. After 10 days hiPSCs differentiated into NCPCs, cells were then maintained in neural induction medium containing defined growth factors for PSNs differentiation, followed by 10 days in neonatal human epidermal keratinocytes- (HEKn-) conditioned medium (CM). We observed a further increase in PSN markers expression and neurites length after CM treatment. The resulting neurons elicited action potentials after current injection and released substance P (SP) in response to nociceptive agents such as anandamide and resiniferatoxin. Anandamide induced substance P release via activation of TRPV1 and not CB1. Transcriptomic analysis of the PSNs revealed the main dorsal root ganglia neuronal markers and a transcriptional profile compatible with C fiber-low threshold mechanoreceptors. TRPV1 was detected by immunofluorescence and RNA-Seq in multiple experiments. In conclusion, the developed strategy generated PSNs useful for drug screening that could be applied to patient-derived hiPSCs, consisting in a powerful tool to model human diseases <i>in vitro</i>.
<i>Marihabitans</i> (2021)

Abstract Ma.ri.ha'bi.tans. L. neut. n. mare sea; L. part. adj. habitans inhabiting; N.L. adj. used as a neut. subst. Marihabitans inhabitant of the sea. Cells are Gram‐stain‐positive, nonmotile, non‐spore‐forming, catalase‐positive, aerobic, and irregular short rods and cocci isolated from surface seawater, deep seawater, and marine sponges, which are 0.9–1.4 μm wide and 1.2–1.7 μm long. The peptidoglycan is of the A type and contains meso ‐A 2 pm, alanine, and glutamic acid. The cell‐wall sugars are galactose, glucose, and ribose. Mycolic acids are absent. The major menaquinone is MK‐8(H 4 ). The phospholipids comprise phosphatidylglycerol, an unknown phospholipid, diphosphatidylglycerol, and phosphatidylinositol mannosides. Phylogenetically, the genus is a member of the family Intrasporangiaceae . Most closely related taxon is the genus Kribbia in the 16S rRNA gene‐based phylogenetic tree. The similarity value of the 16S rRNA gene sequence is 96.3% between the type species, Marihabitans asiaticum HG667 T and Kribbia dieselivorans N113 T . Marihabitans is distinguishable from Kribbia by the absence of saturated fatty acids in the predominant fatty acid profile. The genome sequence of the type species is 2,953,873 bp, and 2,694 protein‐coding genes are predicted. The calculated G + C content is 71.1%. DNA G + C content (mol%) : 71.1% (genome sequence); 70 (HPLC). Type species : Marihabitans asiaticum Kageyama et al. 2008 VP . Taxonomic and Nomenclature Notes According to the List of Prokaryotic names with Standing in Nomenclature (LPSN), the taxonomic status of the genus Marihabitans is: correct name (last update, February 2025) * . LPSN classification: Bacteria / Bacillati / Actinomycetota / Actinomycetes / Micrococcales / Intrasporangiaceae / Marihabitans The genus Marihabitans can also be recovered in the Genome Taxonomy Database (GTDB) as g__Marihabitans (version v220) ** . GTDB classification: d__Bacteria / p__Actinomycetota / c__Actinomycetes / o__Actinomycetales / f__Dermatophilaceae / g__Marihabitans * Meier‐Kolthoff et al. ( 2022 ). Nucleic Acids Res , 50 , D801 – D807 ; DOI: 10.1093/nar/gkab902 ** Parks et al. ( 2022 ). Nucleic Acids Res , 50 , D785 – D794 ; DOI: 10.1093/nar/gkab776
Bouc–Wen Modeling and Inverse Multiplicative Structure to Compensate Hysteresis Nonlinearity in Piezoelectric Actuators (2010)

A new approach to compensate the strong hysteresis nonlinearity in piezoelectric materials is proposed. Based on the inverse multiplicative scheme, the approach avoids models inversion as employed in existing works. The compensator is therefore simple to implement and does not require additional computation as soon as the direct model is available. The proposed compensation technique is valuable for hysteresis that are modeled with the Bouc-Wen set of equations.
Strong surface passivation of GaAs nanowires with ultrathin InP and GaP capping layers (2014)

We demonstrate efficient surface passivation of GaAs nanowires using ultrathin in-situ grown epitaxial InP and GaP capping layers, with metallo-organic vapor phase epitaxy as the growth system. The passivation increased photoluminescence intensity by three orders of magnitude compared to unpassivated nanowires, and the effect remained strong after a month of storage in air. Effective passivation was acquired over a wide range of growth temperatures, although the highest studied temperatures caused additional detrimental effects such as etching and GaAsP formation. The capping layer thickness was in the order of few monolayers. Therefore, the impact on any other properties of the nanowires besides the surface states was minuscule. As a simple and effective method the studied capping layers offer an excellent way for nanowire passivation.
Abstract 314: Development of a Nanotube-coated Nitinol Stent for Delivery of Resolvin D1 (2016)

Introduction: As part of a Vascular Innovation and Therapeutic Advances (VITA) contract from NHLBI, we sought to optimize a nitinol drug eluting stent to deliver a novel bioactive lipid mediator Resolvin D1 (RvD1). Methods: Nitinol stents were secured as the anode in an ethylene glycol-based anodization setup to create nanotubes on the stent surface. Scanning electron microscopy was used to evaluate the quality of the coatings where an iterative process was utilized to optimize anodization conditions (70V, 5min). To ascertain structural integrity of the coatings, stents were observed under SEM after compression in a crimping device followed by self-expansion. Nanotube-coated (NT) and unmodified bare metal (BM) nitinol stents were loaded with RvD1 by dip-coating (with sonication) followed by hanging drop evaporation of RvD1 (in ethanol). Stents were eluted in media and RvD1 levels were analyzed by EIA. An ex vivo model of vascular stent implantation was created using a 3D printer and RvD1 delivery to the vessel wall (segment of rabbit aorta) and circulating flow medium was quantified after 3 hrs of stent implantation. Results: NT stents released significant amounts of RvD1 (1273ng cumulative at day 9), where 1177ng (± 238) of RvD1 was released within 3hr and 0.111ng (± 0.014) of RvD1 was released between day 7 and day 9. Net amount of RvD1 released was 0.2nM - 2000nM, which is physiologically relevant and within the milestone goal. NT stents released much higher levels of RvD1 (9.7 pg/mg vessel; ±1.39) to the vessel wall compared to standard BM stent controls (3.9 pg/mg vessel; ±2.0) and native vessel (1.3 pg/mg vessel; ±0.5). Conclusion: We have developed optimized anodization conditions for creating a uniform coating of titania nanotubes on nitinol stents that is able to survive crimping and self-expansion. NT stents demonstrate improved loading and elution of the lipid mediator RvD1 in an ex-vivo artery flow model.
Figure S1 from &lt;i&gt;LINC00261&lt;/i&gt; Is an Epigenetically Regulated Tumor Suppressor Essential for Activation of the DNA Damage Response (2023)

&lt;p&gt;Figure S1. Bioinformatic analysis of differential lncRNA expression in LUAD. A. Table of samples included in the initial analysis. AEC = Alveolar Epithelial Cells. B. Volcano plot of differential analysis for lncRNA expression.&lt;/p&gt;
ChemInform Abstract: Single Step Synthesis of New Fused Pyrimidine Derivatives and Their Evaluation as Potent Aurora‐A Kinase Inhibitors. (2011)

Abstract Pyrimidine derivatives (IVb) and (IVc) show equipotent cytotoxic activities against HST116 colon tumor cell line compared with reference compound doxorubicin.
Fault Ride Through Capability for Solar Inverters (2012)

A solar inverter for utility scale has been developed in this paper, and the inverter has fault ride through (FRT) capability, which is now discussed in Japan and similar to requirement in U.S.A and Europe. This solar inverter consists of a boost chopper and a three-phase 2-level inverter, and the capacity covers from 20 kW to 600 kW. This paper first describes the FRT capability. Second, how to control the boost chopper and the inverter is shown. Especially, a new inverter current control to achieve FRT capability and dynamic voltage support (DVS) during a grid fault is proposed. After that, several results using an experimental model (5-kW solar inverter) are shown. Finally, results of a prototype model (20 kW), which has been installed in an actual grid, are presented.
Thyrotropin receptor-specific antibodies in BALB/cJ mice with experimental hyperthyroxinemia show a restricted binding specificity and belong to the immunoglobulin G1 subclass. (1995)

Immunization with the extracellular domain of TSH receptor (TSHR) led to the development of hyperthyroxinemia in BALB/cJ, but not C57BL/6J, SJL/J, and B10.BR, mice. Earlier, human studies had shown that thyroid-stimulating antibodies are predominantly of the immunoglobulin G1 (IgG1) subclass with a narrow specificity to TSHR, and antibodies that block thyroid function could be of any subclass with a broader specificity. Therefore, antibody responses in susceptible (BALB/cJ) and resistant (SJL/J) mice were characterized. There were no significant differences in the titers, relative affinities, or isotypes of antibodies against the TSHR. BALB/cJ and SJL/J sera reacted with 2 and 7 of 26 overlapping peptides from the extracellular domain of the TSHR. The ability of sera from BALB/cJ and SJL/J mice to block TSH binding to TSHR was reversed by 1 and 6 of the reactive peptides, respectively. BALB/cJ mice showed predominantly an IgG1 response against the TSHR and peptides, whereas SJL/J mice showed varying levels of all IgG subclasses. Although SJL/J sera reacted with peptides to which blocking antibodies bind, they did not show hypothyroidism, suggesting that their sera contained a mixture of blocking and stimulating antibodies that negated the effects of each other. In contrast, some TSHR-specific antibodies in BALB/cJ probably represented stimulating antibodies.
Network models of protein phosphorylation, acetylation, and ubiquitination connect metabolic and cell signaling pathways in lung cancer (2022)

Abstract We analyzed large-scale post-translational modification (PTM) data to outline cell signaling pathways affected by tyrosine kinase inhibitors (TKIs) in ten lung cancer cell lines. Tyrosine phosphorylated, lysine ubiquitinated, and lysine acetylated proteins were concomitantly identified using sequential enrichment of post translational modification (SEPTM) proteomics. Machine learning was used to identify PTM clusters that represent functional modules that respond to TKIs. To model lung cancer signaling at the protein level, PTM clusters were used to create a co-cluster correlation network (CCCN) and select protein-protein interactions (PPIs) from a large network of curated PPIs to create a cluster-filtered network (CFN). Next, we constructed a Pathway Crosstalk Network (PCN) by connecting pathways from NCATS BioPlanet whose member proteins have PTMs that co-cluster. Interrogating the CCCN, CFN, and PCN individually and in combination yields insights into the response of lung cancer cells to TKIs. We highlight examples where cell signaling pathways involving EGFR and ALK exhibit crosstalk with BioPlanet pathways: Transmembrane transport of small molecules; and Glycolysis and gluconeogenesis. These data identify known and previously unappreciated connections between receptor tyrosine kinase (RTK) signal transduction and oncogenic metabolic reprogramming in lung cancer. Comparison to a CFN generated from a previous multi-PTM analysis of lung cancer cell lines reveals a common core of PPIs involving heat shock/chaperone proteins, metabolic enzymes, cytoskeletal components, and RNA-binding proteins. Elucidation of points of crosstalk among signaling pathways employing different PTMs reveals new potential drug targets and candidates for synergistic attack through combination drug therapy. Author Summary Protein post-translational modifications (PTMs), such as phosphorylation, ubiquitination, and acetylation, are extensively employed by cell signaling pathways that regulate cell division, differentiation, migration, and cancer. We used machine learning to identify PTM clusters that represent functional modules in cell signaling pathways. These clusters were used to identify protein-protein interactions, and interactions between cell signaling pathways, that were active in lung cancer cells that were treated with anti-cancer drugs. We model these interactions as networks at three levels of granularity at the pathway, protein-protein interaction, and PTM levels. Interrogation of these networks yielded insights into molecular interactions between cell signaling pathways activated by oncogenes, transmembrane transport of small molecules, and glycolysis and gluconeogenesis. These analyses identify previously unappreciated mechanisms of crosstalk among signaling pathways between oncogenic tyrosine kinase signaling and proteins that regulate metabolic reprogramming in lung cancer, revealing new potential drug targets for combination therapy.
The role of sex and rurality in cancer fatalistic beliefs and cancer screening utilization in Florida (2021)

Some, but not all, cancer fatalistic beliefs are associated with getting breast and colorectal cancer screening in north-central Florida. Our study highlights the need for more research to better understand the social and cultural factors associated with cancer screening utilization.
Synthesis of γ-Aminopropylphosphonous Acids Using Hypophosphorous Acid Synthons (1987)

Abstract γ-Aminopropylphosphonous acids have been synthesised using hypophosphorous acid synthons