gebhart/patrepeval huggingface dataset:
Repression of IR-Inducible Clusterin Expression by the p53 Tumor Suppressor Protein (2003)

The clusterin (CLU) protein has been reported to have both cytoprotective and cytotoxic activities. Previous data from our lab suggest that the secretory form of CLU (sCLU) is cytoprotective and induced after very low, nontoxic doses of ionizing radiation (IR: >0.02 Gy), while a nuclear form is cytotoxic. Cells must presumably suppress sCLU to stimulate cell death, however, factors regulating the stress-inducible expression of sCLU have not been elucidated. Here we demonstrate that p53 can suppress sCLU induction responses. A variety of cytotoxic agents stimulated sCLU expression and DNA damage was sufficient but not necessary for induction. IR-stimulated CLU promoter activity, with concomitant increases in CLU mRNA and protein, showed that CLU induction was delayed with maximal expression observed 48-96 h post-treatment. Expression of the human papillomavirus E6 protein in MCF-7 breast or RKO colon cancer cells enhanced basal CLU levels. Isogenically matched HCT116 colon cancer cell lines that differed only in p53 or p21 status, confirmed a role for p53 in the transcriptional repression of sCLU. Loss of functional p53 in HCT116:p53(-/-) cells augmented CLU de novo synthesis after IR exposure. Repression of sCLU protein levels by p53 may be important for the cascade of p53-mediated events leading to cell death after IR or other cytotoxic agent exposure.
Characterization of Persister Cells and Some Mutants from Clinical Isolate of A Multidrug-Resistant MRSA (2020)

Background: Some multidrug resistant bacteria such as MRSA, produce persister cells in the presence of bactericidal agents, which enables them to survive in the presence of the antibiotics. Evolution of persisters and the mechanisms of survival are still debatable and difficult to understand. Formation of persister cells establishes phenotypic heterogeneity within a bacterial population, causes relapses of bacterial infections and linked to failed treatments and the emergence of antibiotic resistance. Method : MRSA-derived persisters were isolated under vancomycin stress and mutated by exposure to ultraviolet radiation; 254um. Persister cells and the mutants were classically and biochemically characterized.  Persister cells were further subjected to persister's assay, grown on Baird-Parker medium, tested for biofilm formation, DNase production and mannitol fermentation. Results: Bacteriologically and biochemically persisters were found to be similar to the clinical isolate and standard MRSA strains.  But distinctive differences were observable in the DNase, coagulase and catalase activities. Conclusion : A general method for isolating persisters was developed based on lysis of regular MRSA cells by vancomycin.  These persisters retained all MRSA characteristics but shown down regulated enzyme activities.
Local electronic transport through InAs/InP(0 0 1) quantum dots capped with a thin InP layer studied by an AFM conductive probe (2007)

International audience
Ramipril prevents left ventricular hypertrophy with myocardial fibrosis without blood pressure reduction: a one year study in rats (1992)

1. Angiotensin converting enzyme (ACE)-inhibitors have been demonstrated to be effective in the treatment of cardiac hypertrophy when used in antihypertensive doses. The aim of our one year study with an ACE-inhibitor in rats was to separate local cardiac effects produced by a non-antihypertensive dose from those on systemic blood pressure when an antihypertensive dose was used. 2. Rats made hypertensive by aortic banding were subjected to chronic oral treatment for one year with an antihypertensive dose of the ACE inhibitor, ramipril 1 mg kg-1 daily, (RA 1 mg) or received a low dose of 10 micrograms kg-1 daily (RA 10 micrograms) which did not affect high blood pressure. 3. Chronic treatment with the ACE-inhibitor prevented left ventricular hypertrophy in the antihypertensive rats as did the low dose which had no effects on blood pressure. Similar effects were observed on myocardial fibrosis. Plasma ACE activity was inhibited in the RA 1 mg but not in the RA 10 micrograms group although conversion of angiotensin (Ang) I to Ang II in isolated aortic strips was suppressed in both treated groups. Plasma catecholamines were increased in the untreated control group, but treatment with either dose of ramipril normalized the values. The myocardial phosphocreatine to ATP ratio (an indicator of the energy state in the heart) was reduced in the vehicle control group whereas the hearts from treated animals showed a normal ratio comparable to hearts from sham-operated animals. 4. After one year, five animals were separated from each group, treatment withdrawn, and housed for additional six months. In the RA 1 mg group, blood pressure did not reach the value of the control vehicle group and surprisingly, left ventricular hypertrophy and myocardial fibrosis did not recur in animals during withdrawal of treatment.5. These data show that long term ACE inhibitor treatment with ramipril in antihypertensive and non-antihypertensive doses prevented cardiac hypertrophy and myocardial fibrosis. This protective effect was still present after 6 months treatment withdrawal.
Synthesis and Structure of a Sixteen‐Membered (AINCO)<sub>4</sub> Ring (1993)

The unprecedented ring size in tetramer 1 arises from the alternation of the
Promoting innovative mobile applications via a third party IMS-enabled ecosystem (2008)

Today's IP Multimedia Subsystem (IMS) client on a mobile device provides basic services, including voice, presence, messaging, and contact management. In the future, the IMS client should be prepared to handle a large variety of innovative and unexpected services that integrate into the client seamlessly among existing services. Bell Labs' Client/Service IMS Architecture group has defined a product concept called API for Mobile IMS Client Application (AMICAL) that provides multiple levels of application programming interfaces (APIs) for third parties developing IMS-enabled applications. By using a plug-in framework, AMICAL allows users to enhance the IMS client with innovative features without modifying the proprietary core software. At another level of abstraction via an IMS kernel service, third party developers can write their own application completely independently of the IMS client, yet enable it with IMS features such as presence-enabled objects and easily deployed communication services. These components provide a demonstrably effective means to promote new and innovative IMS-enabled services and applications by third party developers.
Leptin Affects Insulin Action in Astrocytes and Impairs Insulin-mediated Physical Activity (2012)

Our data suggest a crosstalk of leptin and insulin in the brain which leads to a decline in locomotor activity. This might represent a molecular mechanism in obese to inhibit physical activity.
Human apoE Isoforms Differentially Regulate Brain Amyloid-β Peptide Clearance (2011)

The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset, sporadic Alzheimer's disease (AD). The APOE ε4 allele markedly increases AD risk and decreases age of onset, likely through its strong effect on the accumulation of amyloid-β (Aβ) peptide. In contrast, the APOE ε2 allele appears to decrease AD risk. Most rare, early-onset forms of familial AD are caused by autosomal dominant mutations that often lead to overproduction of Aβ(42) peptide. However, the mechanism by which APOE alleles differentially modulate Aβ accumulation in sporadic, late-onset AD is less clear. In a cohort of cognitively normal individuals, we report that reliable molecular and neuroimaging biomarkers of cerebral Aβ deposition vary in an apoE isoform-dependent manner. We hypothesized that human apoE isoforms differentially affect Aβ clearance or synthesis in vivo, resulting in an apoE isoform-dependent pattern of Aβ accumulation later in life. Performing in vivo microdialysis in a mouse model of Aβ-amyloidosis expressing human apoE isoforms (PDAPP/TRE), we find that the concentration and clearance of soluble Aβ in the brain interstitial fluid depends on the isoform of apoE expressed. This pattern parallels the extent of Aβ deposition observed in aged PDAPP/TRE mice. ApoE isoform-dependent differences in soluble Aβ metabolism are observed not only in aged but also in young PDAPP/TRE mice well before the onset of Aβ deposition in amyloid plaques in the brain. Additionally, amyloidogenic processing of amyloid precursor protein and Aβ synthesis, as assessed by in vivo stable isotopic labeling kinetics, do not vary according to apoE isoform in young PDAPP/TRE mice. Our results suggest that APOE alleles contribute to AD risk by differentially regulating clearance of Aβ from the brain, suggesting that Aβ clearance pathways may be useful therapeutic targets for AD prevention.
A zinc calcium phosphorous oxide ceramic and malic acid-Ca(OH)/sub 2/-vitamin E composite for repairing bone defects (2002)

The objective of this investigation was to develop a resorbable zinc calcium phosphorous ceramic oxide (ZCAP) organic acid-vitamin E composite containing an antibiotic for orthopedic and/or dental application, including nearly all cases of trauma of hard tissues. A composite consisting of 3.0 g ZCAP, 1.2 g malic acid, 0.6 g Ca(OH)/sub 2/, 9.6 mg gentamicin sulfate and 20 pl of vitamin E oil was compressed in a 5/16" die into 0.1 g pellets at a load of 2000 lbs in a hydraulic press. The right femur of experimental animals was accessed by routine surgical procedures. A mid-diaphyseal fracture was created under direct vision using a surgical bone saw. A 0.62 threaded K-wire was inserted into the intramedullary canal and retrograded through the knee using a drill. The implant was placed between the two ends of the fracture and the K-wire antegraded through the pellet into the proximal end of the femur and tested to assure good fixation. The K-wire protruding from the bone was cut flush with the end of the bone using wire cutters. The surgical site was closed using routine surgical procedures. Post surgery, each rat showed normal movement during the ten week experimental period. Gross morphological examination of euthanized animals showed filling of the defect. Radiographic examination of the bones showed resorption of the composite, evidence of bone healing and cancellous bone ingrowth. However, the new bone ingrowth appeared less dense than the cortical bone on either side of the defect. The data collected to date suggest that ZCAP composites can be used as osteoconductive fillers between two fractured ends of a bone.
SV40 DNA extracted from persistently infected Vero cells using miniprep columns for plasmids. (1993)

A recombinant pAT153 plasmid carrying the whole simian virus 40 (SV40) genome in the form of two consecutive Pst I restriction fragments was rapidly isolated using a commercially available minipreps DNA purification system. This rapid and simple method was used to extract SV40 DNA from infected Vero monkey cells. Viral DNA replication in persistently infected SVP-1 monkey cells was also conveniently followed over a period of 8 d by agarose gel electrophoresis and molecular hybridization using minipreps and the recombinant plasmid (pLCB104) as a probe. Unsatisfactory results were obtained, however, when herpes simplex virus DNA was tentatively extracted from infected Vero cells with the above method. Only covalently closed circular DNA molecules, with two strands unable to separate fully under denaturing conditions, were apparently retained after rapid neutralization by the silicone-based minipreps DNA purification resin.
Optimal Openness Level and Economic Performance of Firms: Evidence from Belgian CIS Data (2015)

info:eu-repo/semantics/published
METIC agriculture : a resume of identified themes for collaboration (2008)

In the last one hundred years, Maltese agriculture genetic resources were dispersed throughout the Mediterranean basin. The introduction of modern varieties of livestock and plants has led to the complete disregard of all local populations in favour of these imported new exotic hybrids. The end result is that our local genotypes have already been lost or are in danger of becoming extinct. Most are well suited for extensive production systems and also well suited for integration into organic or free range type of production. Projects focusing on the rehabilitation of Mediterranean Woodlands and the use of Treated Sewage Effluent were also discussed. The team of experts from the Faculty of Agriculture at the University of Palermo can be a great asset for the implementation of these initiatives. The development of certified products, compliment the efforts to develop an agrotourist industry.
Prehospital Triage of Acute Stroke Patients During the COVID-19 Pandemic (2020)

The coronavirus disease 2019 (COVID-19) pandemic has broad implications on stroke patient triage. Emergency medical services providers have to ensure timely transfer of patients while minimizing the risk of infectious exposure for themselves, their co-workers, and other patients. This statement paper provides a conceptual framework for acute stroke patient triage and transfer during the COVID-19 pandemic and similar healthcare emergencies in the future.
Performance Analysis of W-CDMA Algorithms on a (2008)

The Software Defined Radio principle is a key technology for mobile devices as well as base stations. Especially femto cells for small-distance indoor environments are of major interest. This paper presents an evaluation of the Embedded Vector Processor (EVP) as one possible principal component of an SDR femto-sized base station. We present results of our performance analysis of selected W-CDMA baseband algorithms. We give a detailed description of the mapping of a SIMO chip- equalizer and an HSDPA downlink spreader on the EVP. The achieved performance demonstrates that the EVP may satisfy real-time requirements of current mobile communication standards.
A compact digital amplitude modulator in 90nm CMOS (2010)

This paper presents a 90 nm CMOS digital amplitude modulator for polar transmitter. It reaches an output power of -2.5 dBmRMS using a WLAN OFDM 64QAM modulation at 2.45GHz achieving -26.1 dB EVM and 18% efficiency. To reduce the aliases due to the discrete-time to continuous-time conversion a 2-fold interpolation has been implemented. The amplitude modulator has a segmented architecture. This results in a very compact 0.007 mm2 chip area.
Incidental pregnancy in trauma (2000)

Bochicchio, Grant MD, MPH; Napolitano, Lena MD; Haan, James MD; Champion, Howard MD; Scalea, Thomas MD Author Information
Shikonin reduces TGF-β1-induced collagen production and contraction in hypertrophic scar-derived human skin fibroblasts (2015)

Hypertrophic scarring/hypertrophic scars (HS) is a highly prevalent condition following burns and trauma wounds. Numerous studies have demonstrated that transforming growth factor-β1 (TGF‑β1) plays an essential role in the wound healing process by regulating cell differentiation, collagen production and extracellular matrix degradation. The increased expression of TGF-β1 is believed to result in the formation of HS. Shikonin (SHI), an active component extracted from the Chinese herb, Radix Arnebiae, has previously been found to downregulate the expression of TGF-β1 in keratinocyte/fibroblast co-culture conditioned medium. In view of this, in this study, we aimed to further investigate the effects of SHI on TGF-β1-stimulated hypertrophic scar-derived human skin fibroblasts (HSFs) and examined the underlying mechanisms. Cell viability and proliferation were measured using alamarBlue and CyQUANT assays. The total amount of collagen and cell contraction were examined using Sirius red staining and the cell contraction assay kit. Gene expression and signalling pathway activation were detected using reverse transcription-quantitative polymerase chain reaction and western blot analysis. Our results revealed that SHI reduced TGF-β1‑induced collagen production through the ERK/Smad signalling pathway and attenuated TGF-β1‑induced cell contraction by downregulating α-smooth muscle actin (αSMA) expression in the HSFs. The data from this study provide evidence supporting the potential use of SHI as a novel treatment for HS.
The Uncertain Energy of an Excited State (2015)

This paper asks an experimental question about photon absorption and emission in a two-state electronic system where the incident frequency of exciting light is below the mean frequency of the emission line but still within the line width. Since it is well known that the absorption spectrum and the emission spectrum are identical [1]-[3], then quantum mechanics as well as astronomical observations say that excitations will still occur. Once a quantum state excites, then it is expected to decay back with a typical time constant and the usual emission spectrum. The problem is that the mean frequency of that emission spectrum will then be higher than the frequency of the exciting photon, suggesting that more energy is emitted than being received on average. A search of quantum mechanical references finds no discussion of this issue, so this paper considers the options available to resolve this inconsistency, including an experiment.
Xylenes and Ethylbenzene (2000)

Abstract This article reviews the properties, commercial manufacturing aspects, and uses of the three xylene isomers, ie, o ‐xylene, m ‐xylene, and p ‐xylene, and the ethylbenzene present in mixed xylene streams. Chemical reactions discussed are migration of the alkyl groups, including 1,2 intramolecular shifts and transalkylation; reactions of the alkyl groups, including oxidation, polycondensation, and ammoxidation; reactions of the aromatic ring; and complex formation. Aspects of commercial manufacture that are covered include initial production of mixed xylenes; separation processes used to produce high purity p ‐xylene, o ‐xylene, and m ‐xylene; and xylene isomerization processes. Catalytic reforming and toluene disproportionation/transalkylation are the primary mixed xylene production routes discussed. The xylene isomer separation processes of crystallization, adsorption, and complex formation are described. The commercially important xylene isomerization processes are reviewed. Worldwide production data for the three xylene isomers and ethylbenzene are presented along with a list of the U.S. producers and their production capacities. Analytical techniques and important health and safety factors are also summarized.
Research on the Premotor Symptoms of Parkinson’s Disease: Clinical and Etiological Implications (2013)

This is an emerging research area with important data gaps to be filled. Future research is needed to understand the prevalence of multiple premotor symptoms and their etiological relevance to PD. Animal experiments and mechanistic studies will further understanding of the biology of these premotor symptoms and test novel etiological hypothesis.
Analysis of DNA fingerprints of Mycobacterium Tuberculosis Isolates from Patients Registered at Health Center in Gyeonggi Province in 2004 (2006)

Background : IS6110 DNA fingerprint is a very useful tool for investigating the transmission of tuberculosis. The aim of this study was to identify the epidemiological situations within a given area (one province). Methods : The 681 Mycbobacterium tuberculosis isolates from patients, who were registered at health centers in Gyeonggi Province from May to December in 2004, were subjected to IS6110 DNA fingerprinting. Patients belonging to clusters were interviewed by health-workers to determine their previous contacts or household TB history. Results : The number of IS6110 copies of the 681 isolates showed diverse fingerprint patterns from 0 to 21 of which the most prevalent copy number was 10 from 120 isolates (17.6%). Thirty-three isolates (4.8%) belonged to the K strain, and 128 isolates (18.8%) belonged to the K family. There were 180 (26.4%) isolates belonged belonging to fifty clusters, of which two clusters were within household transmission. Forty-three (23.9%) out of 180 patients resided in an area under the same health center control. The rate of clusters in those aged 60-70 was higher than in any other age group ( 95% CI of RR : 1.072 ~ 1.988). Conclusion : This is the first report of an epidemiological survey based on a whole province using a DNA fingerprinting technique for M. tuberculosis. These results will be helpful in developing a program or policies to prevent the transmission of TB.
Study of Quantum Dynamics in the Transition from Classical Stability to Chaos (1995)

We report an experimental and theoretical study of momentum transfer from a modulated standing wave of light to a sample of ultracold atoms. This system is a quantum realization of the periodically driven rotor where the underlying classical phase space goes from stable to chaotic as a control parameter is varied. Our experimental results are in good absolute agreement with a quantum Floquet analysis and with a quantum simulation. We relate the quantum evolution to the underlying classical dynamics in this mixed phase space regime.
Hole Cleaning During Deviated Drilling - The Effects of Pump Rate and Rheology (1998)

Abstract In the present paper it is shown that the frictional pressure loss in the annulus is the major contributing part to hole cleaning in deviated wells. A sufficiently large annular frictional pressure loss is required to obtain proper hole cleaning regardless of the drilling fluid design. It is shown that cuttings bed consolidation is the next item to be addressed. A very high frictional pressure loss may be necessary to remove cuttings from the bed if the bed is well consolidated. It is also illustrated how important it is to design a drilling fluid regarding hole cleaning performance at the correct annular frictional pressure loss. P. 161
Postseedling resistance to rust in flax (1980)

Postseedling resistance to rust [Melampsora lint] of flax {Linum usitaiissimum) has been demonstrated in a 1978 field study on cultivars susceptible in the seedling stage to races with virulence to the A' 1 gene.At the late vegetative and full bloom stages the level of postseedling resistance to each of races 72 and 386.and accession 864 was high in the cultivars Noralta and Norland, moderate in Redwood 65. and low in Nored.Similar results were obtained with race 371 in a 1976 field test and in a greenhouse test.The scarcity of rust since 1973 in Canada in plantings of Noralta.Norland, and Redwood 65 suggests that postseedling resistance plays a significant role in the field.On a dmontr la rsistance la rouille du lin au stade aprs-semis dans une tude en champ en 1978 avec varieties susceptibles au stade semis aux races vainquant la rsistance conditionne par le gne N'.Aux stades vgtatif avanc et pleine floraison le niveau de la rsistance au stade aprs-semis vers chacune des races 72 et 386 et accession 864 tait lev pour les cultivars Noralta et Norland, modr pour Redwood 65. et bas pour Nored.Des rsultats semblables ont t obtenus avec la race 371 en champ en 1976 et dans un essai en serre.La raret de la rouille depuis 1973 au Canada dans les champs de Noralta.Norland et Redwood 65 suggre que la rsistance au stade aprs-semis y joue un rle significatif.
What is the Overhead Required for Fault-Tolerant Quantum Computation? (2013)

What is the minimum number of extra qubits needed to perform a large fault-tolerant quantum circuit? Working in a common model of fault-tolerance, I show that in the asymptotic limit of large circuits, the ratio of physical qubits to logical qubits can be a constant. The construction makes use of quantum low-density parity check codes, and the asymptotic overhead of the protocol is equal to that of the family of quantum error-correcting codes underlying the fault-tolerant protocol.