gebhart/patrepeval huggingface dataset:
D1-S169A Substitution of Photosystem II Perturbs Water Oxidation (2019)

In photosystem II (PSII), photosynthetic water oxidation occurs at the tetramanganese–calcium cluster that cycles through light-induced intermediates (S0–S4) to produce oxygen from two substrate waters. The surrounding hydrogen-bonded amino acid residues and waters form channels that facilitate proton transfer and substrate water delivery, thereby ensuring efficient water oxidation. The residue D1-S169 lies in the “narrow” channel and forms hydrogen bonds with the Mn4CaO5 cluster via waters W1 and Wx. To probe the role of the narrow channel in substrate-water binding, we studied the D1-S169A mutation. PSII core complexes isolated from mutant cells exhibit inefficient S-state cycling and delayed oxygen evolution. The S2-state multiline EPR spectrum of D1-S169A PSII core complexes differed significantly from that of wild-type, and FTIR difference spectra showed that the mutation strongly perturbs the extensive network of hydrogen bonds that extends at least from D1-Y161 (YZ) to D1-D61. These results imply a possible role of D1-S169 in proton egress or substrate water delivery.
The mutational landscape of melanoma brain metastases presenting as the first visceral site of recurrence (2020)

Brain metastases are a major cause of melanoma-related mortality and morbidity. We undertook whole-exome sequencing of 50 tumours from patients undergoing surgical resection of brain metastases presenting as the first site of visceral disease spread and validated our findings in an independent dataset of 18 patients. Brain metastases had a similar driver mutational landscape to cutaneous melanomas in TCGA. However, KRAS was the most significantly enriched driver gene, with 4/50 (8%) of brain metastases harbouring non-synonymous mutations. Hotspot KRAS mutations were mutually exclusive from BRAF<sup>V600</sup>, NRAS and HRAS mutations and were associated with a reduced overall survival from the resection of brain metastases (HR 10.01, p = 0.001). Mutations in KRAS were clonal and concordant with extracranial disease, suggesting that these mutations are likely present within the primary. Our analyses suggest that KRAS mutations could help identify patients with primary melanoma at higher risk of brain metastases who may benefit from more intensive, protracted surveillance.
Design of firmware update system of RT-Middleware for embedded system (2010)

In this paper, we propose the design of firmware (FW) update system for RTC-CANopen, including system structure and FW update algorithm. RTC-CANopen enables embedded and robotic systems to use existing CANopen device easily. We developed update algorithm and system based on the CANopen software update standard. Thus, our proposed system is able to support standard CANopen devices. By accomplishing our research, we can easily maintain the FW of embedded system as well as robotic system adopting RTC-CANopen.
Successive Release of Tissue Inhibitors of Metalloproteinase-1 Through Graphene Oxide-Based Delivery System Can Promote Skin Regeneration (2017)

The purpose of this study was to testify the hypothesis that graphene oxide (GO) could act as an appropriate vehicle for the release of tissue inhibitors of metalloproteinase-1 (TIMP-1) protein in the context of skin repair. GO characteristics were observed by scanning electron microscopy, atomic force microscopy, and thermal gravimetric analysis. After TIMP-1 absorbing GO, the release profiles of various concentrations of TIMP-1 from GO were compared. GO biocompatibility with fibroblast viability was assessed by measuring cell cycle and apoptosis. In vivo wound healing assays were used to determine the effect of TIMP-1-GO on skin regeneration. The greatest intensity of GO was 1140 nm, and the most intensity volume was 10,674.1 nm (nanometer). TIMP-1 was shown to be continuously released for at least 40 days from GO. The proliferation and viability of rat fibroblasts cultured with TIMP-1-GO were not significantly different as compared with the cells grown in GO or TIMP-1 alone (p > 0.05). Skin defect of rats treated with TIMP-1 and TIMP-1-GO showed significant differences in histological and immunohistochemical scores (p < 0.05). GO can be controlled to release carrier materials. The combination of TIMP-1 and GO promoted the progression of skin tissue regeneration in skin defect.
Natural killer cell function and expression of beta 7 integrin in psoriatic arthritis. (1994)

In PsA, HML-1 is an activation marker on NK cells. IL-2 expands or maintains the population of HML-1/NKH1 positive cells and increases NK cytolytic activity. However, cytolytic activity of activated NK cells may be inhibited by monocyte derived PGE2.
Hardware‐Assisted Projected Tetrahedra (2010)

Abstract We present a flexible and highly efficient hardware‐assisted volume renderer grounded on the original Projected Tetrahedra (PT) algorithm. Unlike recent similar approaches, our method is exclusively based on the rasterization of simple geometric primitives and takes full advantage of graphics hardware. Both vertex and geometry shaders are used to compute the tetrahedral projection, while the volume ray integral is evaluated in a fragment shader; hence, volume rendering is performed entirely on the GPU within a single pass through the pipeline. We apply a CUDA‐based visibility ordering achieving rendering and sorting performance of over 6 M Tet/s for unstructured datasets. Furthermore, as each tetrahedron is processed independently, we employ a data‐parallel solution which is neither bound by GPU memory size nor does it rely on auxiliary volume information. In addition, iso‐surfaces can be readily extracted during the rendering process, and time‐varying data are handled without extra burden.
MHC class II–restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell–mediated autoimmunity (2010)

Although plasmacytoid dendritic cells (pDCs) express major histocompatibility complex class II (MHCII) molecules, and can capture, process, and present antigens (Ags), direct demonstrations that they function as professional Ag-presenting cells (APCs) in vivo during ongoing immune responses remain lacking. We demonstrate that mice exhibiting a selective abrogation of MHCII expression by pDCs develop exacerbated experimental autoimmune encephalomyelitis (EAE) as a consequence of enhanced priming of encephalitogenic CD4(+) T cell responses in secondary lymphoid tissues. After EAE induction, pDCs are recruited to lymph nodes and establish MHCII-dependent myelin-Ag-specific contacts with CD4(+) T cells. These interactions promote the selective expansion of myelin-Ag-specific natural regulatory T cells that dampen the autoimmune T cell response. pDCs thus function as APCs during the course of EAE and confer a natural protection against autoimmune disease development that is mediated directly by their ability to present of Ags to CD4(+) T cells in vivo.
In memoriam (1996)

Describes the development of performance indicators in the bibliographic records section since 1988. The timeliness of the section’s output was perceived to be more relevant from the user’s point of view than the number of books catalogued, so two key indicators were monitored: the length of time which books spend on the cataloguing shelves and the size of the backlog. The statistics in graphical form to assist planning the section’s work. Time analysis was introduced more recently, both to provide a more meaningful context for the performance indicators and also to put a cost on the section’s activities in the light of current trends towards greater financial accountability and the development of service‐level agreements. Discusses some problems inherent in the use of performance indicators and suggests greater integration between sections.
Preface (2012)

Preventive Environmental Management (PEM) stands for a dynamic synergy of tools and approaches, which can be easily applied by diverse stakeholders in the society. For instance, a PEM expression by industry can be in the form of cleaner production, waste minimization, value addition to wastes, and reducing recalcitrance of wastes. This could also have significant bearing on improving safety and health at the work place and the surroundings. Technocrats active in areas of technology development can analyze gaps in technologies and production practices to first achieve waste minimization and recycling of resources. Engineers and scientists addressing issues of resource conservation and advanced management of wastes can devise pathways for technical improvement. They could thus help in sectoral transitions to cleaner production with significantly lesser material and energy intensities.
Unusually Short RNA Sequences:  Design of a 13-mer RNA that Selectively Binds and Recognizes Theophylline (2005)

RNA plays critical roles in numerous biological processes and constitutes valuable therapeutic targets. RNA is significant not only for its roles in transmitting the genetic code but also for its enzymatic functions in ribozymes and in peptide bond formation in ribosomes. Recent studies have shown that RNAs containing as few as 22 nucleotides can be key elements in cellular functions. This suggests the possibility of using short RNAs as regulatory elements. Here, we show that ligand recognition and selectivity by RNA molecules can occur with only the presence of a binding pocket and as few as six additional scaffolding nucleotides holding the binding pocket in place. A 13-mer RNA truncation of a 33-mer aptamer for theophylline preserves the ability to bind to theophylline and to discriminate against the structurally similar compound caffeine. The truncated aptamer retains nearly all of the same structural elements in its binding site as those present in the original aptamer. This is the first demonstration of selective ligand binding by a 13-mer RNA.
INTERCELLULAR ADHESION MOLECULE-1 ANTISENSE OLIGODEOXYNUCLEOTIDES REDUCES HEPATIC ISCHEMIA/ REPERFUSION INJURY. (2000)

Ghobrial, Rafik M.1; Amersi, Farin F.1; Stecker, Kim2; Kato, Hirohisa1; Melinek, Judy3; Singer, Jeniffer S.1; Mhoyan, Anna1; Zhao, Danyun1; Busuttil, Ronald W.1; Kupiec-Weglinski, Jerzy W.1; Stepkowski, Stanislaw M.4 Author Information
Metal–Support Interactions between Nanosized Pt and Metal Oxides (WO<sub>3</sub> and TiO<sub>2</sub>) Studied Using X-ray Photoelectron Spectroscopy (2011)

Platinum nanoparticles have been selectively deposited on composites of titanium oxide-carbon and tungsten oxide-carbon. Selectivity of the deposition made it possible to investigate changes in electronic properties of both platinum and oxide support, induced by the so-called strong metal–support interactions (SMSI). X-ray photoelectron spectroscopy (XPS) was used, and changes in binding energy of Pt 4f, Ti 2p, and W 4f core-levels and Pt 4f peak asymmetry were determined. These parameters allowed us to state the changes in local electron density, when Pt is deposited on oxide support. In all cases the binding energy of the Pt 4f signal for platinum deposited on an oxide support was significantly lower in comparison to samples where Pt was solely supported onto carbon. The increase in Pt 4f XPS signal asymmetry was observed. This suggests an increased electron density on Pt. No electron donor could be identified from the analysis of the oxide supports. To explain the observed data, at least two effects must be considered: (i) alloy formation between Pt and the oxide support and (ii) partial charge transfer from substrate to Pt, which can be correlated to previously observed increased activity toward oxygen reduction reaction.
ChemInform Abstract: Synthesis of (E,E,E)‐(1,2,3,4‐13C4)‐Geranylgeraniol. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Quantitative analysis of enasidenib in dried blood spots of mouse blood using an increased‐sensitivity LC–MS/MS method: Application to a pharmacokinetic study (2019)

A simple, sensitive and rapid assay method has been developed and validated as per regulatory guidelines for the estimation of enasidenib on mouse dried blood spots (DBS) using liquid chromatography coupled to tandem mass spectrometry with electrospray ionization in the positive-ion mode. The method employs liquid extraction of enasidenib from DBS disks of mouse whole blood followed by chromatographic separation using 0.2% formic acid-acetonitrile (25:75, v/v) at a flow rate of 1.0 mL/min on an Atlantis dC<sub>18</sub> column with a total run time of 2.0 min. The MS/MS ion transitions monitored were m/z 474.0 → 267.1 for enasidenib and m/z 309.2 → 251.3 for the internal standard (warfarin). The assay was linear in the range of 1.01-3044 ng/mL. The within-run and between-run precisions were in the range of 3.18-9.06 and 4.66-8.69%, respectively. Stability studies showed that enasidenib was stable on DBS cards for 1 month. This novel method has been applied to analyze the DBS samples of enasidenib obtained from a pharmacokinetic study in mice.
Rosa spinosissima L. (2001)

https://thekeep.eiu.edu/herbarium_specimens_byname/13132/thumbnail.jpg
Inhibitory control training for appetitive behaviour change: A meta-analytic investigation of mechanisms of action and moderators of effectiveness (2015)

Inhibitory control training (ICT) is a novel intervention in which participants learn to associate appetitive cues with inhibition of behaviour. We present a meta-analytic investigation of laboratory studies of ICT for appetitive behaviour change in which we investigate candidate mechanisms of action, individual differences that may moderate its effectiveness, and compare it to other psychological interventions. We conducted random-effects generic inverse variance meta-analysis on data from 14 articles (18 effect sizes in total). Participants who received ICT chose or consumed significantly less food or alcohol compared to control groups (SMD = 0.36, 95% CIs [0.24, 0.47]; Z = 6.18, p < .001; I(2) = 71%). Effect sizes were larger for motor (Go/No-Go and Stop Signal) compared to oculomotor (Antisaccade) ICT. The effects of ICT on behaviour were comparable to those produced by other psychological interventions, and effects of ICT on food intake were greater in participants who were attempting to restrict their food intake. The magnitude of the effect of ICT on behaviour was predicted by the proportion of successful inhibitions but was unrelated to the absolute number of trials in which appetitive cues were paired with the requirement to inhibit, or the contingency between appetitive cues and the requirement to inhibit. The effect of ICT on cue devaluation (primarily assessed with implicit association tests) was not statistically significant. Our analysis confirms the efficacy of ICT for short-term behaviour change in the laboratory, and we have demonstrated that its effectiveness may depend on pairings between appetitive cues and successful inhibition. We highlight the need for further research to translate these findings outside of the laboratory.
High-Performance Quantum Cascade Lasers for Industrial Applications (2013)

Quantum cascade lasers (QCLs) are semiconductor lasers based on intersubband transitions between energy states created by quantum confinement in the conduction band of semiconductor multilayers. The laser core is composed of hundreds of layers of quantum wells and barrier materials (typically InGaAs/InAlAs) that together define most of the laser properties such as wavelength, bias voltage, and output power, to a degree that is unprecedented among semiconductor devices and that led the inventors of this type of lasers to talk about "materials by design" and "bandgap engineering." The great advantage of QCLs over other laser types in the mid-infrared region of the electromagnetic spectrum (referred to in this paper as the region between 4 and 12 μm) is their ability to use direct electronic transitions for light generation, thus being one of the few, if any, options for direct generation of coherent mid-infrared radiation by electrical pumping with no optical excitation, no second-order processes, no complex alignment procedures, and with the added flexibility of being able to tailor the active material properties to match the desired emission wavelength and characteristics. This powerful tool for spectroscopic analysis can be tuned to match the fingerprint absorption characteristics of several molecules in the mid-infrared, as well as serve many other industrial, security, medical, and environmental applications needing high-power beams at these wavelengths. Powers in the watts range have been demonstrated in several laser configurations and designs and at different wavelengths. In this paper we will focus on the high-power emission from industrial-grade devices fabricated to achieve watt-level powers in the midwave IR (MWIR) and longwave IR (LWIR) regions of the spectrum, i.e., the 3-5 μm and 8-12 μm regions, respectively. In addition, we show how these lasers can be fabricated in order to match low-power-consumption requirements of some single-mode applications, and, finally, how the high power from single emitters can be scaled up in an array configuration.
Galectin-1 (Gal1) and N-glycans regulate the spontaneous development of sialadenitis (2015)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
Incidence of Unintended Durotomy in Spine Surgery Based on 108 478 Cases (2010)

Unintended durotomy occurred in at least 1.6% of spinal surgeries, even among experienced surgeons. Our data provide general benchmarks of durotomy rates and serve as a basis for ongoing efforts to improve safety of care.
Rayleigh theory of ultrasound scattering applied to liquid-filled contrast nanoparticles (2010)

We present a novel modified theory based upon Rayleigh scattering of ultrasound from composite nanoparticles with a liquid core and solid shell. We derive closed form solutions to the scattering cross-section and have applied this model to an ultrasound contrast agent consisting of a liquid-filled core (perfluorooctyl bromide, PFOB) encapsulated by a polymer shell (poly-caprolactone, PCL). Sensitivity analysis was performed to predict the dependence of the scattering cross-section upon material and dimensional parameters. A rapid increase in the scattering cross-section was achieved by increasing the compressibility of the core, validating the incorporation of high compressibility PFOB; the compressibility of the shell had little impact on the overall scattering cross-section although a more compressible shell is desirable. Changes in the density of the shell and the core result in predicted local minima in the scattering cross-section, approximately corresponding to the PFOB-PCL contrast agent considered; hence, incorporation of a lower shell density could potentially significantly improve the scattering cross-section. A 50% reduction in shell thickness relative to external radius increased the predicted scattering cross-section by 50%. Although it has often been considered that the shell has a negative effect on the echogeneity due to its low compressibility, we have shown that it can potentially play an important role in the echogeneity of the contrast agent. The challenge for the future is to identify suitable shell and core materials that meet the predicted characteristics in order to achieve optimal echogenity.
Enhanced indoor localization through crowd sensing (2017)

In localization tasks, one typically assumes a statistical model of the observations, where the model quantifies the observations by exploiting interrelationships based on geometry. These models might incorporate unknown parameters that, in general, are functions of space. In this article, we propose a crowd sensing method for estimating a spatial field of a quantity (e.g., ranging biases due to line-of-sight/non-line-of-sight or path-loss parameter) allowing for improved indoor localization. Our method takes advantage of the information provided by various users that navigate the area of interest. The proposed learning approach is based on Gaussian processes and its computational cost does not increase with the number of measurements. We present numerical results that show how the proposed method estimates a spatial field of biases and how these estimates lead to much improved performance in estimation of user positions.
Lower limb trauma I (2019)

The radiograph is inadequate because it does not show the full pelvis and hips. Otherwise the radiograph shows a displaced subcapital intracapsular neck of femur fracture. I would obtain radiographs in orthogonal views to assess this fracture and consider requesting a CT scan to more fully understand the fracture pattern if necessary.
Noninterference Wearable Strain Sensor: Near-Zero Temperature Coefficient of Resistance Nanoparticle Arrays with Thermal Expansion and Transport Engineering (2021)

In this study, non-temperature interference strain gauge sensors, which are only sensitive to strain but not temperature, are developed by engineering the properties and structure from a material perspective. The environmental interference from temperature fluctuations is successfully eliminated by controlling the charge transport in nanoparticles with thermally expandable polymer substrates. Notably, the negative temperature coefficient of resistance (TCR), which originates from the hopping transport in nanoparticle arrays, is compensated by the positive TCR of the effective surface thermal expansion with anchoring effects. This strategy successfully controls the TCR from negative to positive. A near-zero TCR (NZTCR), less than 1.0 × 10<sup>-6</sup> K<sup>-1</sup>, is achieved through precisely controlled expansion. Various characterization methods and finite element and transport simulations are conducted to investigate the correlated electrical, mechanical, and thermal properties of the materials and elucidate the compensated NZTCR mechanism. With this strategy, an all-solution-processed, transparent, highly sensitive, and noninterference strain sensor is fabricated with a gauge factor higher than 5000 at 1% strain, as demonstrated by pulse and motion sensing, as well as the noninterference property under variable-temperature conditions. It is envisaged that the sensor developed herein is applicable to multifunctional wearable sensors or e-skins for artificial skin or robots.