gebhart/patrepeval huggingface dataset:
Spinal epidural hematoma following coronary thrombolysis with tissue plasminogen activator (1995)

Two cases of spinal epidural hematoma following intravenous administration of recombinant tissue-type plasminogen activator are presented. Both patients received thrombolytic therapy for acute myocardial infarction; back pain and progressive neurological dysfunction ensued, secondary to spinal cord compression caused by epidural hematoma. Both individuals underwent emergency surgery for decompression and hematoma evacuation, resulting in improvement in neurological function. The current status of thrombolytic therapy is reviewed, with emphasis on complications of therapy that require neurosurgical intervention.
Efficient production of immunodeficient non-obese diabetic/Shi-scid <i>IL2r<b>γ</b></i><sup>null</sup> mice via the superovulation technique using inhibin antiserum and gonadotropin (2020)

Severe immunodeficient mice are an essential tool for the examination of the efficacy and safety of new therapeutic technologies as a humanized model. Previously, non-obese diabetic (NOD)/Shi-scid <i>IL2rγ</i><sup>null</sup> (NOG) mice were established as immunodeficient mice by combining interleukin-2 receptor-γ chain-knockout mice and NOD/Shi-scid mice. The NOG mice are used frequently in the research of therapeutic monoclonal antibodies and regenerative medicine for human diseases. Establishment of an efficient production system of NOG mice, using optimized reproductive techniques, is required to accelerate research. In this study, we investigated the efficacy of the superovulation technique using equine chorionic gonadotropin (eCG) and inhibin antiserum (IAS) in NOG mice of various ages (4, 8, 12, 24, or 54 weeks). Additionally, we examined the fertilizing and developmental ability of the oocytes through <i>in-vitro</i> fertilization using frozen-thawed sperm, embryo culture and embryo transfer. The results showed that NOG mice produced the highest number of oocytes at 12 weeks old following the co-administration of eCG and IAS (collectively IASe) (70 oocytes/female). IASe was more effective in increasing the number of oocytes v. eCG at all ages. The IASe-derived oocytes demonstrated the ability to fertilize and develop into blastocysts and pups. Finally, we demonstrated that three strains of genetically modified NOG mice were efficiently produced through the optimized reproductive techniques. In summary, we developed an efficient system for the production of immunodeficient mice using 12-week-old, IASe-treated female NOG mice.
[A case of ALL complicated with acute pancreatitis and pancreatic pseudocyst caused by L-asparaginase ]. (1993)

We reported a case of ALL complicated with acute pancreatitis caused by L-asparaginase (L-Asp). The patient was a 42-year-old man, who showed eosinophilia in peripheral blood and an increase of lymphoblast in bone marrow. He was diagnosed as ALL (L2) and treated by JALSG '87 protocol. Remission induction chemotherapy including L-Asp was administered by 5,000 IU i.v. for 10 days. The day after giving all dose of L-Asp, slight epigastralgia developed and then became severe. After two days, s-amylase was markedly elevated, and the patient was diagnosed as acute pancreatitis caused by L-Asp. He was treated conservatively, but hyperglycemia occurred. The epigastrial tumor was palpable and gradually grew in size. CT-scan and abdominal ultrasonography revealed pancreatic pseudocyst, so he was treated by percutaneous cyst drainage. The patient died of a relapse of ALL. The prophylaxis and early diagnosis of the pancreatitis and hyperglycemia caused by L-Asp are very difficult. We have to examine more cases and pay greater attention to the chemotherapy, including L-Asp.
Practical implications of gene-expression-based assays for breast oncologists (2020)

Gene-expression profiling has had a considerable impact on our understanding of breast cancer biology, and more recently on clinical care. Two statistical approaches underlie these advancements. Supervised analyses have led to the development of gene-expression signatures designed to predict survival and/or treatment response, which has resulted in the development of new clinical assays. Unsupervised analyses have identified numerous biological signatures including signatures of cell type of origin, signaling pathways, and of cellular proliferation. Included within these biological signatures are the molecular subtypes known as the ‘intrinsic’ subtypes of breast cancer. This classification has expanded our appreciation of the heterogeneity of breast cancer and has provided a way to sub-classify the disease in a manner that might have clinical utility. In this Review, we discuss the clinical utility of gene-expression-based assays and their technical potential as clinical tools vis-a-vis the performance of breast cancer biomarkers that are the current standard of care.
High Error Rates in Selenocysteine Insertion in Mammalian Cells Treated with the Antibiotic Doxycycline, Chloramphenicol, or Geneticin (2013)

Antibiotics target bacteria by interfering with essential processes such as translation, but their effects on translation in mammalian cells are less well characterized. We found that doxycycline, chloramphenicol, and Geneticin (G418) interfered with insertion of selenocysteine (Sec), which is encoded by the stop codon, UGA, into selenoproteins in murine EMT6 cells. Treatment of EMT6 cells with these antibiotics reduced enzymatic activities and Sec insertion into thioredoxin reductase 1 (TR1) and glutathione peroxidase 1 (GPx1). However, these proteins were differentially affected due to varying errors in Sec insertion at UGA. In the presence of doxycycline, chloramphenicol, or G418, the Sec-containing form of TR1 decreased, whereas the arginine-containing and truncated forms of this protein increased. We also detected antibiotic-specific misinsertion of cysteine and tryptophan. Furthermore, misinsertion of arginine in place of Sec was commonly observed in GPx1 and glutathione peroxidase 4. TR1 was the most affected and GPx1 was the least affected by these translation errors. These observations were consistent with the differential use of two Sec tRNA isoforms and their distinct roles in supporting accuracy of Sec insertion into selenoproteins. The data reveal widespread errors in inserting Sec into proteins and in dysregulation of selenoprotein expression and function upon antibiotic treatment.
Disease-Associated Antibodies in Offspring of Mothers with IDDM (1996)

We studied 20 infants of mothers with IDDM participating in a pilot study for a dietary intervention trial, testing the hypothesis that avoidance of cow's milk proteins early in life will reduce the risk of subsequent IDDM. The aim was to evaluate the elimination of IDDM-associated antibodies from the peripheral circulation of the infants, the possible emergence of autoantibodies indicating beta-cell destruction, and the influence of the dietary intervention and genetic disease susceptibility on the development of these autoantibodies. Transplacentally transferred islet cell antibodies (ICAs) and antibodies to the 65-kDa isoform of glutamic acid decarboxylase (GAD65As) disappeared from the peripheral circulation of most infants over the first few months of life and in all infants before the age of 9 months. Insulin antibodies were eliminated before the same age in all cases but one. The higher the initial antibody level was, the longer the time required for elimination. Four infants tested positive for insulin autoantibodies (IAAs) on at least one occasion during the first year of life, and 5 out of 16 unaffected subjects (31%) had IAAs at the age of 2 years. One infant became positive for IAA before the age of 6 months, with increasing levels later, seroconverted to positivity for ICAs and GAD65As between 6 and 9 months and presented with clinical IDDM at the age of 14 months. He had the HLA DQB1*0302/x genotype, which predisposes carriers to IDDM, and had been given the casein hydrolysate formula as supplementary milk. There were no significant differences in the levels of various autoantibodies between two groups of subjects defined either on the type of dietary intervention or the degree of genetic susceptibility. The findings indicate that transplacentally transferred antibodies related to IDDM are usually eliminated from the peripheral circulation of infants before 9 months of age and that IDDM-associated autoantibodies may emerge before the age of 6 months. Our results also illustrate that avoidance of cow's milk proteins over the first 9 months of life does not provide total protection against IDDM.
Laser Additive Manufacturing of F/M Steels for Radiation Tolerant Nuclear Components (2017)

According to the Nuclear Energy R&D Roadmap Report submitted to Congress in 2010, one the key challenges facing the nuclear energy industry involves development of new reactor designs with reduced capital costs. Two related R&D objectives outlined in the report include: 1) Making improvements in the affordability of new reactors; and 2) Development of structural materials to withstand irradiation for longer periods. Laser additive manufacturing (LAM) is particularly well suited for more rapid and economical fabrication of reactor components relative to current fabrication methods. The proposed work involving LAM directly addresses the two R&D objectives outlined above relevant to the pertinent mission problems. The classical Materials Science approach involving development of Process/Structure/Property/Performance (P/S/P/P) relations was employed in this project. Processing included LAM and heat-treating. Thermal cycling during LAM is discussed here, and phase diagrams and continuous cooling transformation (CCT) diagrams are used to rationalize microstructural evolution. Structures were characterized including grain size & morphology, volume fraction, morphology, composition and location of carbides in as-deposited and heat-treated conditions. In the simplest sense, the goal was to control microstructures through process manipulation with a view toward optimizing properties and performance in service.
Colangiopatie infiammatorie e neoplastiche (2018)

The biliary tree consists of mature epithelial cells called cholangiocytes and is subdivided in intra and extrahepatic bile ducts. They facilitate the secretion and modification of the bile constituents and act as transport ducts of bile to the intestine. The alteration of the normal function of cholangiocyte, can lead to the development of multiple biliary diseases, known as cholangiopathies, generally chronic, with a progressive course and which often are lacking of an effective treatment, determining a poor prognosis, even lethal, for the patient. These cholangiopathies have peculiar characteristics both for onset and clinical course. The pathogenetic processes affecting cholangiocytes are not yet fully known. Depending on their nature, these diseases are further subdivided into genetic, idiopathic, which include primary biliary cholangitis, primary sclerosing cholangitis and associated IgG4 cholangitis and malignant such as cholangiocarcinoma or mixed hepato-cholangiocarcinoma. This review is focused on the new insights on the pathophysiological and molecular mechanisms involved in the liver damage cascade which provide the basis of novel therapeutic approaches for these cholangiopathies.
Solubility of<scp>l</scp>-Phenylalanine Anhydrous and Monohydrate Forms: Experimental Measurements and Predictions (2012)

In this work the solubility of l-phenylalanine anhydrous and monohydrate forms in pure water, a water + acetone mixture, and a water + ethanol mixture at various temperatures were measured systematically using the gravimetric method as well as predicted using the universal quasichemical (UNIQUAC) model. Generally the solubility increased with the temperature and decreased with an increase in the content of acetone or ethanol in the solvent mixtures. The two forms were found to be enantiotropically related, and the transition temperature was about 308.9 K. Besides, the UNIQUAC model was demonstrated to work well for the prediction of the solubility of this pseudopolymorphic system in water and its binary mixtures with a low content of organic solvent.
Methods: A Comparative Analysis of Radiography, Microcomputed Tomography, and Histology for Bone Tissue Engineering (2005)

This study focused on the assessment of radiography, microcomputed tomography, and histology for the evaluation of bone formation in a 15.0-mm defect in the rabbit radius after the implantation of a tissue-engineered construct. Radiography was found to be useful as a noninvasive method for obtaining images of calcified tissue throughout the time course of the experiment. With this method, however, image quality was low, making it difficult to obtain precise information about the location and quantity of the bone formed. Microcomputed tomography was used to create three-dimensional reconstructions of the bone (25-microm resolution). These reconstructions allowed for greater spatial resolution than the radiography, but did not allow for imaging of the implanted scaffold material or the surrounding, nonmineralized tissue. To visualize all materials within the defect area at the cellular level, histology was used. Histological analysis, however, is a destructive technique that did not allow for any further analysis of the samples. Each technique examined here has its own advantages and limitations, but each yields unique information regarding bone regeneration. It is only through the use of all three techniques that complete characterization of the bone growth and tissue/construct responses after implantation in vivo.
<i>Staphylococcus aureus</i> synthesizes adenosine to escape host immune responses (2009)

Staphylococcus aureus infects hospitalized or healthy individuals and represents the most frequent cause of bacteremia, treatment of which is complicated by the emergence of methicillin-resistant S. aureus. We examined the ability of S. aureus to escape phagocytic clearance in blood and identified adenosine synthase A (AdsA), a cell wall-anchored enzyme that converts adenosine monophosphate to adenosine, as a critical virulence factor. Staphylococcal synthesis of adenosine in blood, escape from phagocytic clearance, and subsequent formation of organ abscesses were all dependent on adsA and could be rescued by an exogenous supply of adenosine. An AdsA homologue was identified in the anthrax pathogen, and adenosine synthesis also enabled escape of Bacillus anthracis from phagocytic clearance. Collectively, these results suggest that staphylococci and other bacterial pathogens exploit the immunomodulatory attributes of adenosine to escape host immune responses.
Thermal Characterization of SiC Modules for Variable Frequency Drives (2019)

In this paper, the advantages of SiC power modules to reduce peak junction temperature and power cycling effects are presented. A detailed power loss calculation and thermal model is developed and tested on a 480 V, 190A, 150 HP variable frequency drive (VFD) with SiC modules. A comparison between the SiC module and an equivalent rated Si module is presented to demonstrate the reduction in power cycling effects, particularly at low speed operation. Infrared (IR) imaging results and an analytical explanations of the phenomenon is provided. These results show that SiC inverters can be used for high torque and low speed applications. Also, the reduction in junction temperature swing improves reliability.
Thermal-independent properties of PIN-PMN-PT single-crystal linear-array ultrasonic transducers (2012)

In this paper, low-frequency 32-element linear-array ultrasonic transducers were designed and fabricated using both ternary Pb(In(1/2)Nb(1/2))-Pb(Mg(1/3)Nb(2/3))-PbTiO(3) (PIN-PMN-PT) and binary Pb(Mg(1/3)Nb(2/3))-PbTiO(3) (PMNPT) single crystals. Performance of the array transducers was characterized as a function of temperature ranging from room temperature to 160°C. It was found that the array transducers fabricated using the PIN-PMN-PT single crystal were capable of satisfactory performance at 160°C, having a -6-dB bandwidth of 66% and an insertion loss of 37 dB. The results suggest that the potential of PIN-PMN-PT linear-array ultrasonic transducers for high-temperature ultrasonic transducer applications is promising.
Dhalion (2017)

In recent years, there has been an explosion of large-scale real-time analytics needs and a plethora of streaming systems have been developed to support such applications. These systems are able to continue stream processing even when faced with hardware and software failures. However, these systems do not address some crucial challenges facing their operators: the manual, time-consuming and error-prone tasks of tuning various configuration knobs to achieve service level objectives (SLO) as well as the maintenance of SLOs in the face of sudden, unpredictable load variation and hardware or software performance degradation. In this paper, we introduce the notion of self-regulating streaming systems and the key properties that they must satisfy. We then present the design and evaluation of Dhalion, a system that provides self-regulation capabilities to underlying streaming systems. We describe our implementation of the Dhalion framework on top of Twitter Heron, as well as a number of policies that automatically reconfigure Heron topologies to meet throughput SLOs, scaling resource consumption up and down as needed. We experimentally evaluate our Dhalion policies in a cloud environment and demonstrate their effectiveness. We are in the process of open-sourcing our Dhalion policies as part of the Heron project.
Formation of magnetite and iron-rich carbonates by thermophilic iron-reducing bacteria (1997)

Laboratory experiments were performed to study the formation of iron minerals by a thermophilic (45 - 75 degree(s)C) fermentative iron-reducing bacterial culture (TOR39) obtained from the deep subsurface. Using amorphous Fe(III) oxyhydroxide as an electron acceptor and glucose as an electron donor, TOR39 produced magnetite and iron-rich carbonates at conditions consistent, on a thermodynamic basis, with Eh (-200 mV to -415 mV) and pH (6.2 to 7.7) values determined for these experiments. Analyses of the precipitating solid phases by X-ray diffraction showed that the starting amorphous Fe(III) oxyhydroxide was nearly completely converted to magnetite and Fe-rich carbonate after 20 days of incubation. Increasing bicarbonate concentration in the chemical milieu resulted in increased proportions of siderite relative to magnetite and the addition of MgCl2 caused the formation of magnesium-rich carbonate in addition to siderite. The results suggest that the TOR39 bacterial culture may have the capacity to form magnetite and iron-rich carbonates in a variety of geochemical conditions. These results may have significant implications for studying the past biogenic activities in the Martian meteorite ALH84001.
Primary Ocular Recurrence of Leukemia Following Bone Marrow Transplant (1993)

A patient with acute lymphoblastic leukemia (ALL) who had undergone an allogeneic bone marrow transplant that included high-dose chemotherapy and total body radiation without eye shielding, sustained an isolated relapse of her disease in the iris. A review of ocular leukemic disease is discussed.
High-speed tunable fractional-delay allpass filter structure (2003)

By using a fractional delay (FD), a filter can perform various operations such as asynchronous sample rate conversion, synchronization of digital modems and sound synthesis of musical instruments. An IIR tunable FID filter can be designed using Thiran-based FD allpass filter structure. However, this IIR structure has the disadvantage of long critical path and large hardware overhead. In this paper, a modified Thiran-based FD allpass filter structure is proposed. Compared with the existing structure, the proposed structure requires shorter critical path, less hardware complexity and improved frequency characteristics.
Lightning Experiments on the Säntis Tower (Invited Lecture) (2014)

SCI-STI-FR
Ferromagnetic Bare Metal Stent for Endothelial Cell Capture and Retention (2015)

Rapid endothelialization of cardiovascular stents is needed to reduce stent thrombosis and to avoid anti-platelet therapy which can reduce bleeding risk. The feasibility of using magnetic forces to capture and retain endothelial outgrowth cells (EOC) labeled with super paramagnetic iron oxide nanoparticles (SPION) has been shown previously. But this technique requires the development of a mechanically functional stent from a magnetic and biocompatible material followed by in-vitro and in-vivo testing to prove rapid endothelialization. We developed a weakly ferromagnetic stent from 2205 duplex stainless steel using computer aided design (CAD) and its design was further refined using finite element analysis (FEA). The final design of the stent exhibited a principal strain below the fracture limit of the material during mechanical crimping and expansion. One hundred stents were manufactured and a subset of them was used for mechanical testing, retained magnetic field measurements, in-vitro cell capture studies, and in-vivo implantation studies. Ten stents were tested for deployment to verify if they sustained crimping and expansion cycle without failure. Another 10 stents were magnetized using a strong neodymium magnet and their retained magnetic field was measured. The stents showed that the retained magnetism was sufficient to capture SPION-labeled EOC in our in-vitro studies. SPION-labeled EOC capture and retention was verified in large animal models by implanting 1 magnetized stent and 1 non-magnetized control stent in each of 4 pigs. The stented arteries were explanted after 7 days and analyzed histologically. The weakly magnetic stents developed in this study were capable of attracting and retaining SPION-labeled endothelial cells which can promote rapid healing.
High-density Information Storage by Means of Magnetic Holography on Amorphous TbFe Thin Films (II) (1987)

The recording characteristics and hologram patterns of data storage by magnetic holography are described in detail. When the reconstruction was like a spatially filtered image of the original pattern, it was observed that the middle part of the contour of each character of the original pattern was saturated by the excess intensity of the object beam. It was found that the recording margin in magnetic holography is very small, and is strongly affected by the original data pattern. Adjustment of intensity of the object and reference beams at the recording stage is thus very important.