gebhart/patrepeval huggingface dataset:
Results of total knee arthroplasty after failed proximal tibial osteotomy for osteoarthritis. (1987)

The cases of twenty-one consecutive patients who had a minimally constrained total knee arthroplasty (six of whom had a cemented and fifteen, an uncemented prosthesis) after a failed proximal tibial osteotomy for osteoarthritis were compared with those of a non-consecutive group of twenty-one patients who had had a primary total knee arthroplasty for osteoarthritis. The groups were matched according to age and sex of the patient, type of prosthesis and fixation, and length of follow-up. At an average length of follow-up of 2.9 years, a good or excellent result was obtained in 81 per cent of the patients who had had a previous osteotomy. At an average length of follow-up of 2.8 years, a good or excellent result was obtained in 100 per cent of the patients who had had a primary arthroplasty. Two patients in the osteotomy group and none in the primary arthroplasty group required additional surgery. At the time of arthroplasty, technical difficulties in exposing the proximal part of the tibia were noted in three patients in the group that had undergone an osteotomy. The results of total knee arthroplasty after failed proximal tibial osteotomy approached but did not equal the results after primary total knee arthroplasty.
<i>Reg IV:</i> A Promising Marker of Hormone Refractory Metastatic Prostate Cancer (2005)

The diagnosis and management of prostate cancer is hampered by the absence of markers capable of identifying patients with metastatic disease. In order to identify potential new markers for prostate cancer, we compared gene expression signatures of matched androgen-dependent and hormone refractory prostate cancer xenografts. One candidate gene overexpressed in a hormone refractory xenograft was homologous to the regenerating protein gene family, a group of secreted proteins expressed in the gastrointestinal tract and overexpressed in inflammatory bowel disease and cancer. This gene, Reg IV, was confirmed to be differentially expressed in the LAPC-9 hormone refractory xenograft. Consistent with its up-regulation in a hormone refractory xenograft, it is expressed in several prostate tumors after neoadjuvant hormone ablation therapy. As predicted by its sequence homology, it is secreted from transiently transfected cells. It is also expressed strongly in a majority of hormone refractory metastases represented on two high-density tissue microarrays. In comparison, it is not expressed by any normal prostate specimens and only at low levels in approximately 40% of primary tumors. These data support Reg IV as a candidate marker for hormone refractory metastatic prostate cancer.
The effect of shoulder muscle succinylcholine injection on the foreleg raising power: Sion's local paralysis (2023)

Compared with the control group, the foreleg raising power in the intervention group immediately decreased significantly and persisted for a period after SLP, without hypoxia, in a pig model.
Transparent data for the M2M service capability layer: benefits and approaches (2014)

A central goal of Machine-to-Machine Communication is to offer a common horizontal integration platform for various domains, devices, and applications. The automotive domain is considered as an intrinsic part. Besides, visions, associated with future connected vehicles towards Intelligent Transportation Systems and In-Car Multimedia systems, require new (distributed) automotive software architectures. For these reasons, a M2M-based Automotive Service Delivery Platform is an advantageous solution. This paper outlines the data handling within current M2M Communication Architectures, based on an Extended Floating Car Data use-case. On this basis, existing limitations, caused by opaque data, are discussed. Since datadependent filter criteria are not realizable with current M2M subscribe/notify mechanisms, data acquisition can only be tailored to specific application requirements in a very limited way. This causes a high communication overhead, particularly for complex devices, like vehicles, potentially offering a vast amount of data at a high rate. We motivate data-dependent filter criteria e.g. with respect to subscribe/notify and subscription mediation capabilities. As a solution, this paper proposes making data transparent to the M2M Service Capability Layer and presents approaches to implement necessary enhancements.
High throughput parallel backside contacting and periodic texturing for high-efficiency solar cells (2023)

Disclosed are configurations of long-range ordered features of solar cell materials, and methods for forming same. Some features include electrical access openings through a backing layer to a photovoltaic material in the solar cell. Some features include textured features disposed adjacent a surface of a solar cell material. Typically the long-range ordered features are formed by ablating the solar cell material with a laser interference pattern from at least two laser beams.
Angular feature mapping: an optical method (1990)

An optical method is demonstrated where the angles at which line segments in a pattern intersect are estimated and mapped.
Prealbumin as a Serum Biomarker of Impaired Perioperative Nutritional Status and Risk for Surgical Site Infection after Spine Surgery (2015)

All patients except one who developed postoperative deep wound infection after spine surgery had serum prealbumin levels in the malnutrition range at the time of presentation. The current study suggests serum prealbumin levels may be an inexpensive screening biomarker for nutritional status and risk stratification for postoperative infection after spine surgery.
Abstract 702: New Insights Into the Lipid/protein Composition of HDL Particles (2019)

High density lipoprotein (HDL) particles are dynamic molecular assemblies with characteristic size and floatation range based on the lipid [phospholipids (PL), free cholesterol (FC), cholesteryl esters (CE), and triglycerides (TG)] and protein content. HDL particle composition has pathophysiologic relevance in numerous disease states. Better understanding of HDL composition requires preparative isolation and compositional characterization of HDL sub-populations. In this work, five HDL sub-populations (α1, α2, α3, α4 and preβ1) were isolated from plasma of 65 individuals by preparative 2D nPAGE. The electroeluted sub-populations were further purified by apoA-I affinity capture. In each fraction, apos (A-I, A-II, A-IV, C-I, C-II, C-III and E), non-polar lipids (FC, CE, and TG), and PL classes (PC, SM, PE, PI, LPC) were quantified by LC-MS/MS techniques, PL classes in a species-specific manner, yielding %mole measures within corresponding PL-classes. Molar concentration of the different size HDL particles (HDL-P) were determined by volumetric calculations. The total theoretical molecular volume in each fraction was divided by the average spherical volume of one mole of particles, which was estimated from data on particle size, defined by 2D nPAGE,(11&gt;9.4&gt;8.4&gt;7.7&gt;6.8 nm in the order of α1&gt;α2&gt;α3&gt;α4&gt;preβ1). The relative percentile (% of total HDL-P) of HDL particles were: α1=8%, α2=42%, α3=22%, α4=14% and preβ1=13%. Calculation of analytes/HDL-P molar concentration ratios yielded number of apoA-I molecule/particle estimates (α1=3.9, α2=2.9, α3=2.6, α4=2.3, and preβ1=2.1) that are in agreement with previous studies. TG, apoC-I, apoC-II, and apoC-III were the most abundant in the large α1 particles. TG/CE ratio was lower in the LpA-I:A-II particles (α2 and α3) compared to the LpA-I-only particles. Preβ1 particles had the highest FC/CE ratio. Interestingly, the preβ1 particles contained an average of ~60 lipid molecules of which ~18 were CE+TG. In 33 samples we also acquired LCAT and CETP concentration/activity information. Standard least square effect screening revealed significant correlations of these proteins with the particle specific composition measures, including phospholipid species composition.
The use of clinical case management for early stage Alzheimer' patients and their families (2000)

A number of studies have investigated the effectiveness of community based interventions to delay placement for persons with Alzheimer's disease (AD) and to ease caregiver burden, with mixed results. However, much of this research involved subjects who were in later stages of AD or the disease stage was not specified. Some researchers have suggested that the timing of interventions in these studies contributed to negative outcomes. This paper presents the results of a project which provided a comprehensive home care program to persons with early stage AD and their primary caregivers over a period of 18 months. Results indicated that caregivers in the treatment group felt less burdened at six months than caregivers in the control group and institutionalization was delayed for patients (with mild to moderate impairment) in the treatment group. These differences seem most attributable to the case management service provided to persons in the treatment group which featured supportive counseling, referral, skill training and education.
Robust Conditional GAN from Uncertainty-Aware Pairwise Comparisons (2020)

Conditional generative adversarial networks have shown exceptional generation performance over the past few years. However, they require large numbers of annotations. To address this problem, we propose a novel generative adversarial network utilizing weak supervision in the form of pairwise comparisons (PC-GAN) for image attribute editing. In the light of Bayesian uncertainty estimation and noise-tolerant adversarial training, PC-GAN can estimate attribute rating efficiently and demonstrate robust performance in noise resistance. Through extensive experiments, we show both qualitatively and quantitatively that PC-GAN performs comparably with fully-supervised methods and outperforms unsupervised baselines. Code and Supplementary can be found on the project website*.
Forced‐flow electrophoresis of proteins and viruses (1987)

This article describes a model for forced-flow electrophoresis (FFE), considering the desired species fraction removal, other fraction removals, and outlet concentrations of all species in the system. The model predicts the necessary inlet flow rate of the retentate chamber and the rate of filtration and the voltage gradient and also provides an appropriate heat balance permitting consideration of possible heat denaturation of the species. The equipment consists of two membranes and a filter, the electric field being imposed by means of external electrodes, and two fractions are obtainable. The main discriminating factor is not the pore sizes of the filter but the relative solute ionization, which depends on the pH and the ionic strength of the buffer solution. Serum proteins (albumin, gamma-globulin) and bacteriophages (M13, MS2, phiX174) have been used to characterize the separation process.
Magnetic Resonance Angiography in the Pig using Hyperpolarized Water (2015)

Introduction Magnetic Resonance Angiography (MRA) is an important tool in diagnostics of medical conditions such as emboli, stenosis and aneurysms. Sub-millimetre resolution can be obtained with proton imaging, and further optimization can be obtained with Gd-based blood pool agents1. However, the acquisition time is several minutes, and conventional MRA methods thus fail to image within a single respiration or heartbeat and therefore suffers from motion artefacts. We demonstrate that hyperpolarized (HP) water can be used as an imaging agent to provide subsecond angiographies in pigs. Previous work on hyperpolarization for imaging agents in large animals has mainly been focused of 13C 2,3, but small volumes of hyperpolarized water with lower polarization has been demonstrated4,5. Injection of hyperpolarized protons allows for the use of MRI coils and pulse sequences already existing in the clinic. Secondly, the magnetization achievable with hyperpolarized water is superior to other nuclei. Methods A 1 mL sample of 50% water and 50% glycerol with 30 mM TEMPO is polarized in a Spinlab (GE Healthcare) at 5 T, 0.9 K, 139.9 GHz for an hour. The sample is rapidly dissolved in 16 mL deoxygenized dissolution medium (DM) consisting of 1 mM EDTA, 50 mM sodium L-ascorbate, 1.9 mM NaH2PO4 and 8 mM Na2HPO4 dissolved in D2O. The DM is filled in the syringe with 7.6 g nonaflourobutyl methyl ether, which will accelerate the dissolution process and extract radical from the polar phase, and hence extend the T1. 10 mL deoxygenized heptane is added to the receiver to further extract the radical. The polarization is quantified in two ways: 1) the signal integral (FID amplitude) is compared to a thermally polarized, pure water reference sample (110 M) and 2) the line width due to radiation damping is compared to the radiation broadening of a thermally polarized, pure water sample. The two methods agree. Proton concentration is quantified by NMR measurement of the dissolved sample added a reference molecule. The images are acquired on a 3 T MRI system (GE healthcare) with a 4 channel array surface coil with a gradient echo sequence with 5 ° flip angle, slice thickness of 40 mm, TR = 3.4 ms, TE = 0.9840 ms, 256x256 matrix, FOV = (140 mm)2. The acquisition time is 870 ms. 15 mL HP substance is injected over 5 s, initiated 15 s after dissolution through a catheter in the right renal artery of a 40 kg pig. Results The protons are polarized by dissolution DNP to an enhancement of more than 2000 times at 9.4 T, corresponding to a polarization of 13% at time of injection. T1 of ~20 s is achieved in vitro for a 1H concentration of 4.5 M. A zoom of a renal MRA is shown in Figure 1. The image maps minor branches of the renal arteries, and the perfusion can be traced over time (time series not shown).
Heterodyning scheme employing quantum interference (1998)

We propose a fundamentally new method of heterodyne detection of FIR signals using quantum interference between one- and two-photon absorption. We suggest different implementations of the scheme using multiple QW detectors and evaluate its sensitivity.
Comparing immunogenicities of tumor-specific antigens administered as therapeutic vaccines in metastatic melanoma patients (2007)

3003 Background: Therapeutic vaccination of metastatic melanoma patients with detectable disease is followed by some tumor regression in only about 10% of the patients, with no clear difference observed between studies carried out with various tumor-specific antigens and vaccination modalities. For antigenic peptide MAGE-A3 168–176 , presented by HLA-A1 molecules and administered as peptide alone or recombinant ALVAC poxvirus, anti-vaccine T lymphocyte (CTL) responses have been observed in no progressor patient and in only half of the regressors, suggesting a poor immunogenicity of these vaccines. Methods and Results: We compiled anti-vaccine CTL responses measured in the blood of 202 metastatic melanoma patients vaccinated with various associations of 10 different tumor antigens administered as peptides, alone or with adjuvant, recombinant ALVAC poxvirus, or peptide-pulsed dendritic cells. Blood lymphocytes collected before and after vaccination were all analyzed with the same method involving in vitro restimulation in limiting dilution condition followed by labeling with tetramers for each antigen. A CTL response was deemed to have occurred if the CTL frequency increased by at least 10 times, and if the pre-vaccination frequency was lower than 2 x 10 -6 of the CD8 cells. No responses were detected against peptides MAGE- A4 230–239 (0/26) and MAGE-C2 336–344 (0/22). Some were observed against MAGE-A3 168–176 (11/81), MAGE-A1 278–286 (2/22), MAGE-A3 112–120 (2/55), and MAGE-A10 254–262 (2/35). Responses were frequently found against NY-ESO-1 157–165 (10/19), GnTV VLPDVFIRC (18/73), gp100 209–217 (21/33), or Tyrosinase 369–377 (11/59). For the latter four antigens, there was no correlation between the occurrence of CTL responses and that of tumor regressions. Neither did we find a correlation between the CTL responses and the expression of the antigen-encoding genes in pre- vaccination tumor samples. Conclusions: These results suggest that some of the antigenic peptides that are commonly used in melanoma vaccines are more immunogenic than others but do not induce more tumor regressions. Therefore, inducing strong CTL responses against these immunogenic peptides is probably not the most appropriate endpoint of future vaccine trials. No significant financial relationships to disclose.
Lone-pair-lone-pair repulsion in the halogen molecules (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLone-pair-lone-pair repulsion in the halogen moleculesWilliam L. Jolly and Charles J. EyermannCite this: Inorg. Chem. 1983, 22, 10, 1566Publication Date (Print):May 1, 1983Publication History Published online1 May 2002Published inissue 1 May 1983https://pubs.acs.org/doi/10.1021/ic00152a031https://doi.org/10.1021/ic00152a031research-articleACS PublicationsRequest reuse permissionsArticle Views106Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Self Calibrating Visual Sensor Networks (2008)

This paper presents an unsupervised data driven scheme to automatically estimate the relative topology of overlapping cameras in a large visual sensor network. The proposed method learns the camera topology by employing the statistics of co-occurring observations (of moving targets) in each sensor. Since target observation data is typically very noisy in realistic scenarios, an efficient two step method is used for robust estimation of the planar homography between camera views. In the first step, modes in the co-occurrence data are learned using meanshift. In the second step, a RANSAC based procedure is used to estimate the homography from weighted co-occurrence modes. Note that the first step not only lessens the effects of noise but also reduces the search space for efficient calculation. Unlike most existing algorithms for overlapping camera calibration, the proposed method uses an update mechanism to adapt online to the changes in network topology. The method does not assume prior knowledge about the scene, target, or network properties. It is also robust to noise, traffic intensity, and the amount of overlap between the fields of view. Experiments and quantitative evaluation using both synthetic and real data are presented to support the above claims.
Multiple sclerosis. (1994)

Differences in the risk of multiple sclerosis depending on racial background, and the high clinical concordance rates in monozygotic compared with dizygotic twins, have stimulated attempts to identify and locate genes that confer susceptibility to the disease. The risk of multiple sclerosis is increased from 1 in 800 in northern European Caucasians to 1 in 3 in the monozygotic co-twins of affected individuals, with intermediate rates for siblings, offspring and more distant relatives. Concordance rates in monozygotic and dizygotic co-twins of affected individuals rise to 35% and 15%, respectively when magnetic resonance imaging is used to supplement clinical evidence for disease status. The increased recurrence risk in relatives of patients with multiple sclerosis is consistent with a model in which more than one gene contributes to susceptibility. Population studies have demonstrated an association with the class 2 major histocompatibility complex (MHC) phenotypes DR15 and DQw6 and their corresponding genotypes DRB1.1501, DRB5.0101 and DQA1.0102, DQB2.0602. An extensive search, using population studies, for other polymorphic alleles involved in restriction of the immune response may have yielded an additional candidate gene in the VH2-5 immunoglobulin heavy-chain variable region. Identity by descent analysis of candidate genes encoded within the alpha-chain of the T-cell receptor and the gene for myelin basic protein has failed to demonstrate linkage; paradoxically, this is also true for the MHC class 2 region, despite the population association. However, studies involving a large number of sibling pairs have reported a bias in the distribution of T-cell receptor beta-chain variable region haplotype sharing, favouring linkage. This becomes more marked when stratification is made for the presence of DR2 in both affected siblings, suggesting an interaction between genetic polymorphisms encoded within the MHC and T-cell receptor genes, as expected from their known functional co-operation in antigen presentation. The same is true for the immunoglobulin heavy chain, providing provisional evidence for linkage to a gene encoded within the immunoglobulin heavy-chain variable region in families reported from the UK. Taken together, these findings demonstrate the importance of family studies in elucidating the genetic basis of multiple sclerosis, and confirm that several genes are involved, one or more of which regulates genetic restriction of the immune response. The contribution made by the susceptibility genes that have provisionally been identified, occurring in isolation or together, can account for only a proportion of the increased risk of multiple sclerosis implicated by family studies.(ABSTRACT TRUNCATED AT 250 WORDS)
The valuing of the indicator of a regional industrial development: The fuzzy logic approach (2016)

The article discusses the possibility of valuing of the aggregated industrial development level index for the region by fuzzy-set method. Input variables were determined based on System of regional indicators (SRI) in the component of the ≪Industry and Entrepreneurship≫. In the study identified the factors influencing the industrial development level of the region, formed the linguistic scale for evaluation of an aggregated index, and calculated the index for the Murmansk and the Yamalo-Nenets District of Russia. Assessment and comparison of the industrial development level of regions was made. The indicator can be used to monitor the industrial development of the regions and decision making in development of regional economic policy.
Decomposition of silane on Si(111)-(7×7) and Si(100)-(2×1) surfaces below 500 °C (1990)

Using static secondary ion mass spectrometry (SIMS) to observe the silicon hydride species formed by silane adsorption on atomically clean single crystal silicon surfaces, two distinct adsorption mechanisms are identified. Dissociation to SiH3 plus H occurs on the Si(100)-(2×1) surface, which contains pairs of dangling bonds located on Si dimers (with Si–Si distance ≊2.4 Å). In contrast, SiH2 formation in the adsorption step is indicated on the Si(111)-(7×7) surface, where adjacent dangling bonds are separated by more than 7 Å. Lower limits on the silane reactive sticking coefficient (SR) are evaluated using hydrogen coverage (ΘH) measurements after calibrated SiH4 exposures, and this limit is ≊10−5 for 25 °C gas and 100–500 °C surface temperatures. Within experimental error, SR is the same for both mechanisms on the two clean surfaces (ΘH near zero). Dependence of SR on ΘH is reported at 400 °C for both surfaces, and differences appear as ΘH exceeds 0.1 H/Si. Silane adsorption is weakly activated on Si(111)-(7×7), as evidenced by enhanced adsorption as TS is increased between 50 and 400 °C.