gebhart/patrepeval huggingface dataset:
Mechanisms of hydrazine toxicity in rat liver investigated by proteomics and multivariate data analysis (2004)

A proteomics approach combined with multivariate data analysis was used to examine the hepatotoxic effect of hydrazine in 30 male Sprague Dawley rats, assigned to four treatment groups and two control groups. Liver samples from the individual animals were resolved by two-dimensional differential gel electrophoresis (2-D DIGE) and protein patterns from the 2-D gels were analyzed by principal component analysis (PCA) and partial least squares regression (PLSR). The PCA plot was able to describe the variation in the protein expression related to dose and time, by separation or clustering of different animal groups. PLSR followed by variable selection (Jack-knifing) was used to select proteins that varied significantly in relation to the dose related response of the hydrazine treatment. The 10 up-regulated and 10 down-regulated proteins with highest rank in the PLSR model were identified by mass spectrometry. Hydrazine treatment induced altered expression of proteins related to lipid metabolism, Ca(2+) homeostasis, thyroid hormone pathways and stress response. Several of the identified proteins have not previously been implicated in hydrazine toxicity and may thus be regarded as new potential biomarkers of induced liver toxicity.
Design of potent grain refiners for wrought aluminium alloys (2013)

Al–B binary alloys cannot nucleate commercial purity aluminium, while Al–Ti binary alloys offer a modest grain refinement that relies only on the growth restriction capacity of Ti. The stoichiometric Al–Ti–B alloy, on the other hand, provides a fully equiaxed structure across the section of the cast sample with an average grain size under 200 μm, endorsing the potency of the TiB2 particles. The grain refining efficiency is even better when the Ti concentration of the master alloy is in excess of the TiB2 stoichiometry. The excess Ti alloys that contain TiB2 and Al3Ti particles offer a remarkable grain refining capacity with an average grain size of ∼100 μm 5 min after inoculation. The grain refinement efficiency peaks at a Ti/B ratio of 4·3, producing an average grain size of 83±9 μm.
interpretation of the instabilities under ac electric fields in thick samples of S*<sub>c</sub>liquid crystals (1988)

Abstract We explain by a simplified theory the existence of the undulation instability found by us in thick samples of planar oriented S*c liquid crystals. We derive the order of magnitude of the threshold field and explain the minimum in the frequency dependence of the unwinding critical field Ec as well.
Quantitative assessment of platelet morphology by light scattering: a potential method for the evaluation of platelets for transfusion. (1984)

Normal fresh platelets are discoid, and platelets that have been stored become spherical. Discoid morphology correlates with normal viability and imparts to a platelet suspension a "streaming" appearance when agitated. We developed a device that quantitates the percent of discoid cells in a suspension by means of laser light scattering at low angles. It performs this assay within 3 minutes on platelets contained in a plastic blood bag. The ability of the device to quantitate discoid platelets was demonstrated in the following ways: (1) comparison of percentage discs calculated from light-scattering data with visually observed optical streaming; (2) correlation of percentage discs from light scattering with the percentage determined by phase microscopy; and (3) observation of changes during room temperature storage. Platelet suspensions containing extreme (dendritic and balloon) forms were examined, and we conclude that these forms do not significantly affect the light-scattering assay. The optical measurements were also used to accurately approximate the total platelet counts of the suspensions. This device may have a role in the evaluation of platelets for transfusion.
Highly efficient TEM_00 operation of transversely diode-pumped Nd:YAG lasers (1992)

Improved pumping geometries and tailored cavity modes result in a 32% optical-to-optical slope efficiency for TEM00 output from a transversely diode-pumped Nd:YAG laser. Energies of 60 mJ are obtained for multimode operation and 50 mJ for single-mode operation, which represent an 80% extraction of the multimode energy as TEM00 output. The electrical slope efficiency for TEM00 operation is 17%.
&lt;title&gt;Satellite signature effects by ranging system and satellite attitude&lt;/title&gt; (1997)

Residuals of AJISAI ranging data are investigated for single-photon detection and multi-photon detection by comparing our simulation model with actual range data. The simulated distribution histogram for a single-photon system based on our model agrees well with that obtained by the Herstmonceux station. We also found the variations in the AJISAI's center-of-mass correction for multi-photon systems was linked to the satellite attitude as a result of doing a spectral analysis of the Orroral station's data.
Hepatitis B Vaccines and HPV Vaccines Have Been Hailed as Major Public Health Achievements in Preventing Cancer—Could a Schistosomiasis Vaccine be the Third? (2015)

DOAJ is a unique and extensive index of diverse open access journals from around the world, driven by a growing community, committed to ensuring quality content is freely available online for everyone.
Effect of Novel Marine Nutraceuticals on IL-1<i>α</i>-Mediated TNF-<i>α</i>Release from UVB-Irradiated Human Melanocyte-Derived Cells (2011)

UV-induced inflammation and reactive oxygen species formation are involved in the development of melanoma. Natural products like 5β-scymnol and CO(2)-supercritical fluid extract (CO(2)-SFE) of mussel oil contain anti-inflammatory and antioxidant properties that may aid in reducing the deleterious effects of UV radiation. Therefore, their effect on the release of the proinflammatory cytokine, tumour necrosis factor-α (TNF-α), from UVB-irradiated human melanocytic cells was examined. Human epidermal melanocytes (HEM) and MM96L melanoma cells were exposed to UVB radiation and IL-1α. Cell viability and TNF-α levels were determined 24 hours after-irradiation while p38 mitogen-activated protein kinase (MAPK) activation was observed at 15 min after-irradiation. When α-tocopherol, CO(2)-SFE mussel oil, and 5β-scymnol were added to the UVB-irradiated HEM cells treated with IL-1α, TNF-α levels fell by 53%, 65%, and 76%, respectively, while no inhibition was evident in MM96L cells. This effect was not due to inhibition of the intracellular p38 MAPK signalling pathway. These compounds may be useful in preventing inflammation-induced damage to normal melanocytes.
Cuffless blood pressure measuring devices: review and statement by the European Society of Hypertension Working Group on Blood Pressure Monitoring and Cardiovascular Variability (2022)

Cuffless BP devices have considerable potential for changing the diagnosis and management of hypertension. However, fundamental questions regarding their accuracy, performance, and implementation need to be carefully addressed before they can be recommended for clinical use.
High Volume Component Fabrication of Ready-to-Stack Components for Planar SOFC Concepts (2009)

Abstract not Available.
National minorities and European Integration (2006)

Clanak iznosi kriticki pregled razvoja europskih standarda zastite (nacionalnih) manjina. Oživljavanje diskursa o nacionalnim manjinama primarno je bila reakcija Zapada na neocekivano teske etnicke sukobe, s velikim migracijskim tokovima u (novim) postkomunistickim zemljama. Mogu se razlikovati dvije faze i dva puta u razvoju instrumenata zastite europskih manjina do 1995. Na pocetku se cinilo da je Europska Unija, zajedno s drugim europskim asocijacijama (Savjet Europe, OESCE), spremna primijeniti napredne standarde manjinskih prava (ukljucujuci i grupna prava i teritorijalnu samoupravu). Međutim, ubrzo je prevagnuo interes onih država clanica koje ne priznaju nacionalne manjine ili nisu željele nista mijenjati u svojim nacionalnim aranžmanima statusa svojih (nacionalnih) manjina. tako se ostalo na negativnoj (posrednoj) zastiti zasnovanoj na nacelima nediskriminacije.
Relationship of Predicted Risk of Developing Invasive Breast Cancer, as Assessed with Three Models, and Breast Cancer Mortality among Breast Cancer Patients (2016)

Among cases assessed with three models, higher predicted risk of developing breast cancer was not associated with greater risk of breast cancer death; thus, these models would have limited utility in planning studies to evaluate breast cancer mortality reduction strategies. Further, when offering women counseling, it may be useful to note that high predicted risk of developing breast cancer does not imply that if cancer develops it will behave aggressively.
Circulating antibodies against p53 protein in patients with ovarian carcinoma (1996)

BACKGROUND Genetic alterations of the p53 tumor suppressor protein are the most frequent molecular events in human carcinogenesis. For as yet unknown reasons, mutant p53 often acts as an immunogen for autoantibody generation. These autoantibodies can be detected in the serum of cancer patients. The presence of such antibodies has been identified in a subset of patients with ovarian carcinoma, but their clinical significance has not been investigated. METHODS Serum samples from patients with ovarian carcinoma were quantitatively analyzed for the presence of p53 autoantibodies with a time-resolved immunofluorometric procedure. Tumor p53 overexpression was assessed by immunohistochemical analysis of tissue sections. Kaplan–Meier survival curves were calculated for p53 antibody positive and negative patients, and the Cox model was used to evaluate the strength of the associations between the presence of serum p53 antibodies and cancer relapse or death, and also between the presence of such antibodies and other clinicopathologic features. RESULTS P53 antibodies were detected in the serum of 41 of 174 patients with ovarian carcinoma (24%). Antibody levels ranged from a few hundred to 9 × 106 arbitrary Units/L, and fluctuated during the course of the disease. p53 antibody positive patients tended to have tumors overexpressing p53, but the association between the two parameters was not statistically significant (P = 0.13). There was also no association between the presence of p53 antibodies and clinical stage, tumor histologic type, or overall patient survival. However, these antibodies were more frequently present in patients older than 50 years (P = 0.001), in patients with moderately or poorly differentiated tumors (P = 0.001), and in patients who received chemotherapy (P = 0.015), and who suffered relapse after surgery (P = 0.018). In univariate analysis, p53 antibody positive patients were at an increased risk for relapse but not death. In multivariate analysis, the differences in disease free and overall survival between patients who were p53 antibody positive or negative were not statistically significant. CONCLUSIONS P53 autoantibodies are found frequently in the serum of patients with ovarian carcinoma. The presence of such autoantibodies was associated with older patient age, more aggressive tumors, and reduced patient disease free survival. In multivariate analysis the prognostic value of p53 autoantibodies was not statistically significant. Cancer 1996;78:2146-52.
Virtual-crystal approximation that works: Locating a compositional phase boundary in<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi mathvariant="normal">Pb</mml:mi><mml:mo>(</mml:mo><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Zr</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi>−</mml:mi><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ti</mml:mi></mml:mrow><mml:mrow><mml:mi>x</mml:mi></mml:mrow></mml:msub></mml:mrow><mml:mo>)</mml:mo><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">O</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math> (2000)

We present a method for modeling disordered solid solutions, based on the virtual crystal approximation (VCA). The VCA is a tractable way of studying configurationally disordered systems; traditionally, the potentials which represent atoms of two or more elements are averaged into a composite atomic potential. We have overcome significant shortcomings of the standard VCA by developing a potential which yields averaged atomic properties. We perform the VCA on a ferroelectric oxide, determining the energy differences between the high-temperature rhombohedral, low-temperature rhombohedral, and tetragonal phases of $\mathrm{Pb}({\mathrm{Zr}}_{1\ensuremath{-}x}{\mathrm{Ti}}_{x}){\mathrm{O}}_{3}$ at $x=0.5$ and comparing these results to superlattice calculations and experiment. We then use our method to determine the preferred structural phase at $x=0.4.$ We find that the low-temperature rhombohedral phase becomes the ground state at $x=0.4,$ in agreement with experimental findings.
Research and development of 469QJ methanol engine (2010)

When a gasoline engine is changed into a methanol engine which is fueled with pure methanol (M100), the engine will present higher power performance, higher economical efficiency and lower emission. The performance of cold-start, however, becomes worse, which is inconvenient for users. This paper introduces 469QJ's structural characteristic, cold-start technology used in 469QJ engine and the relevant experiments. 469QJ, the self-determined research and development methanol engine, is an EFI engine and has four valves per cylinder. Cold-start technology is developed especially for methanol engine (M100). The experiments show that reasonable cooling and lubrication system makes it possible for methanol engine to have higher reliability performance and longer life. At the same time, the experiments show that the cold-start technology is efficient to improve the methanol engine's performance.
Numerical Key Performance Indicators for the Validation of PHM Health Indicators with Application to a Hydraulic Actuation System (2013)

In order to perform Prognostic and Health Management (PHM) of a given system, it is necessary to define some relevant variables sensitive to the different degradation modes of the system. Those variables are named Health Indicators (HI) and they are the keystone of PHM. However, they are subject to a lot of uncertainties when computed in real time and the stochastic nature of PHM makes it hard to evaluate the efficiency of a HI set before the extraction algorithm is implemented. This document introduces Numerical Key Performance Indicators (NKPI) for the validation of HI computed only from data provided by numerical models in the upstream stages of a PHM system development process. In order to match as good as possible the reality, the multiple sources of uncertainties are quantified and propagated into the model. After having introduced the issue of uncertain systems modeling, the different NKPI are defined and eventually an application is performed on a hydraulic actuation system of an aircraft engine.
Systematic Testing of Convolutional Neural Networks for Autonomous\n Driving (2017)

We present a framework to systematically analyze convolutional neural\nnetworks (CNNs) used in classification of cars in autonomous vehicles. Our\nanalysis procedure comprises an image generator that produces synthetic\npictures by sampling in a lower dimension image modification subspace and a\nsuite of visualization tools. The image generator produces images which can be\nused to test the CNN and hence expose its vulnerabilities. The presented\nframework can be used to extract insights of the CNN classifier, compare across\nclassification models, or generate training and validation datasets.\n
Generative adversarial networks for reconstruction of three-dimensional porous media from two-dimensional slices (2022)

In many branches of earth sciences, the problem of rock study on the microlevel arises. However, a significant number of representative samples is not always feasible. Thus the problem of the generation of samples with similar properties becomes actual. In this paper we propose a deep learning architecture for three-dimensional porous medium reconstruction from two-dimensional slices. We fit a distribution on all possible three-dimensional structures of a specific type based on the given data set of samples. Then, given partial information (central slices), we recover the three-dimensional structure around such slices as the most probable one according to that constructed distribution. Technically, we implement this in the form of a deep neural network with encoder, generator, and discriminator modules. Numerical experiments show that this method provides a good reconstruction in terms of Minkowski functionals.
Book reviews (2002)

Mediation in the Yugoslav Wars. The Critical Years 1990–1995. BY SAADIA TOUVAL. London and New York: Palgrave Macmillan, 2001. Pp.xiv+211. £35.00/$45.00. ISBN 0–333–96503–5. Kazakhstan: Unfulfilled Promise, by MARTHA BRILL OLCOTT. Washington, DC: Carnegie Endowment for International Peace, 2002. Pp.322.$24.95 (pb), $44.00 (hb). ISBN 0–87003–188–0 (pb); 0–87003–189–9 (hb). Michael Ignatieff, Human Rights as Politics and Idolatry. Edited and introduced by AMY GUTMANN. Princeton, NJ: Princeton University Press, 2001. Pp.187, index, ISBN 0–691–08893–4, €24.43/£l3.95.
ELEVATED C-MYC EXPRESSION IN PRIMARY PROSTATE TUMOR PREDICTS BIOCHEMICAL RECURRENCE (2009)

You have accessJournal of Urology1 Apr 2009ELEVATED C-MYC EXPRESSION IN PRIMARY PROSTATE TUMOR PREDICTS BIOCHEMICAL RECURRENCE Dorota Hawksworth, Yongmei Chen, Lakshmi Ravindranath, Inger Rosner, Bungo Furusato, Jennifer Cullen, Isabell A Sesterhenn, David G McLeod, Shiv Srivastava, and Gyorgy Petrovics Dorota HawksworthDorota Hawksworth More articles by this author , Yongmei ChenYongmei Chen More articles by this author , Lakshmi RavindranathLakshmi Ravindranath More articles by this author , Inger RosnerInger Rosner More articles by this author , Bungo FurusatoBungo Furusato More articles by this author , Jennifer CullenJennifer Cullen More articles by this author , Isabell A SesterhennIsabell A Sesterhenn More articles by this author , David G McLeodDavid G McLeod More articles by this author , Shiv SrivastavaShiv Srivastava More articles by this author , and Gyorgy PetrovicsGyorgy Petrovics More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(09)61442-7AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "ELEVATED C-MYC EXPRESSION IN PRIMARY PROSTATE TUMOR PREDICTS BIOCHEMICAL RECURRENCE." The Journal of Urology, 181(4S), p. 511 © 2009 by American Urological AssociationFiguresReferencesRelatedDetails Volume 181Issue 4SApril 2009Page: 511 Advertisement Copyright & Permissions© 2009 by American Urological AssociationMetricsAuthor Information Dorota Hawksworth More articles by this author Yongmei Chen More articles by this author Lakshmi Ravindranath More articles by this author Inger Rosner More articles by this author Bungo Furusato More articles by this author Jennifer Cullen More articles by this author Isabell A Sesterhenn More articles by this author David G McLeod More articles by this author Shiv Srivastava More articles by this author Gyorgy Petrovics More articles by this author Expand All Advertisement PDF downloadLoading ...
New Approaches on Material Design for High-Performance 2-Stroke Engine Bearings (2010)

When looking at the performance criteria of bearings for the application in Two-Stroke engines, properties like emergency running capabilities, embedability and the fatigue properties are vital to the performance of these engines. The typical approach is to use materials with a soft Tin matrix and hard intermetallic phases commonly known as “Babbitt” alloys. In a second, more recent approach, Aluminium alloys with elevated Tin content are more and more often chosen. Babbitts outmatch any bearing alloys by their outstanding tribological performance but have very limited mechanical properties. Oppositely, the Aluminium alloys have substantial higher strength but leak somehow with regard to emergency running properties. Whereas the poorer running properties of Aluminium Alloys can be overcome by using suitable running-in coatings, the strength increase of the Tin matrices of Babbitts is rigorously limited by the production technology of spin casting and the ban of hazardous alloying elements such as Cadmium. In order to satisfy the needs of engines manufacturers for a material which combines the advantages of Aluminium- and Tin-base alloys, a new approach which combines both metallurgical alloy development and process technology redesign is necessary. By a fundamental process analysis, the limiting effect with regard to alloy tuning of the existing production technology for steel-babbitt bearing shells will be shown in this paper. Further more, new process routings with the effect of enabling the production of Babbitt bearings with never practized alloy compositions with enhanced mechanical properties are presented.
Evaluating the Potential of Pyriproxyfen Dissemination using Mosquito Home System against Aedes albopictus at a Dengue Hotspot Area (2021)

Aedes mosquitoes were found to lay their eggs in the cryptic breeding sites. Eliminating cryptic and open breeding sites is essential in reducing dengue virus transmission. However, it is often challenging for health officers to assess these breeding sites which are usually missed during larval surveillance. The autodissemination approach may produce a better outcome by manipulating female mosquitoes to disperse insecticide to other Aedes spp. mosquito habitats. Thus, the present study aims to evaluate the effectiveness of the pyriproxyfen autodissemination technique using Mosquito Home System against the population of mosquitoes. This study was conducted in Bandar Baru Bangi, Selangor, Malaysia. The Mosquito Home System was deployed to control Aedes spp. populations at treatment sites using before-after-control-impact (BACI) design. The presence of pyriproxyfen distribution was confirmed using the WHO larval bioassay which resulted in 10-35% larvae mortalities. Autodissemination of pyriproxyfen significantly reduced the population size of mosquito eggs (p&lt;0.05), larvae (p&lt;0.05), and ovitrap index (p&lt;0.05) at the treatment areas compared to the control areas. Moreover, rainfall was correlated positively against ovitrap index (r = 0.247), larvae (r = 0.420), and eggs (r = 0.422). The study provides promising results for controlling Aedes spp. populations and also highlights the potentials of this technique as an alternative in vector control programmes. However, further studies on larger scale field trials are warranted.
Successful pulmonary administration of activated recombinant factor VII in diffuse alveolar hemorrhage (2006)

Symptomatic therapy of DAH after intrapulmonary administration of one or more doses of rFVIIa was found to have a good to excellent hemostatic effect in six consecutive patients with DAH. The intrapulmonary administration of rFVIIa seemed to have a high benefit-to-risk ratio. Larger series should confirm the safety of this approach.