gebhart/patrepeval huggingface dataset:
RELATION BETWEEN THE LONGITUDINAL DEVELOPMENT OF DAILY PHYSICAL ACTIVITY AND AEROBIC POWER WITH LIPOPROTEIN LEVELS 864 (1996)

In this study the longitudinal relations between daily physical activity(DPA) and maximal aerobic power (VO2-max) with lipoprotein levels (i.e. total serum cholesterol (TC), high density lipoprotein cholesterol (HDL) and the TC/HDL ratio) were investigated in a population of 181 males and females over a period of 15 years (between 13 and 27 years of age). DPA was measured by a structured interview and VO2-max was directly measured by a treadmill test until exhaustion. The longitudinal relations were analysed under correction of the development of dietary parameters, body fatness, smoking behaviour and alcohol consumption with generalized estimating equations (GEE). The advantage of using GEE is that all available longitudinal data are used i.e. the relations at different time points are tested simultaneously leading to a single standardized regression coefficient(β), which quantifies the relations over the entire longitudinal period of 15 years. The results of this longitudinal multivariate analysis showed that the longitudinal development of HDL was positively related to VO2-max (β=0.09;ρ=0.02) and DPA (β=0.05;ρ=0.04). The development of the TC/HDL ratio was inversely related to VO2-max(β=-0.08;ρ=0.05). No significant relations between VO2-max and DPA and TC were found. All observed relations were equal for males and females. From this longitudinal study it can be concluded that both VO2-max and DPA were only slightly related to a low riskprofile according hypercholesteremia.
A survey of microalgal resistance to algal pond crashes. (2020)

Abstract not provided.
Two-dimensional FIR filter design by transformation (1999)

This article extends the McClellan (1973) transformation method so that new types of one-dimensional (1-D) filters can be transformed, and new types of two-dimensional (2-D) filters can be designed. Two procedures are presented for the design of complex and real, positive- and negative-symmetric, 2-D filters. The first procedure is used to design complex 2-D filters with a rectangular region of support having odd-length sides, whereas the second procedure is used for filters with a rectangular region of support having even-length sides.
Nanoplasmonic sensors for biointerfacial science (2017)

In recent years, nanoplasmonic sensors have become widely used for the label-free detection of biomolecules across medical, biotechnology, and environmental science applications. To date, many nanoplasmonic sensing strategies have been developed with outstanding measurement capabilities, enabling detection down to the single-molecule level. One of the most promising directions has been surface-based nanoplasmonic sensors, and the potential of such technologies is still emerging. Going beyond detection, surface-based nanoplasmonic sensors open the door to enhanced, quantitative measurement capabilities across the biointerfacial sciences by taking advantage of high surface sensitivity that pairs well with the size of medically important biomacromolecules and biological particulates such as viruses and exosomes. The goal of this review is to introduce the latest advances in nanoplasmonic sensors for the biointerfacial sciences, including ongoing development of nanoparticle and nanohole arrays for exploring different classes of biomacromolecules interacting at solid-liquid interfaces. The measurement principles for nanoplasmonic sensors based on utilizing the localized surface plasmon resonance (LSPR) and extraordinary optical transmission (EOT) phenomena are first introduced. The following sections are then categorized around different themes within the biointerfacial sciences, specifically protein binding and conformational changes, lipid membrane fabrication, membrane-protein interactions, exosome and virus detection and analysis, and probing nucleic acid conformations and binding interactions. Across these themes, we discuss the growing trend to utilize nanoplasmonic sensors for advanced measurement capabilities, including positional sensing, biomacromolecular conformation analysis, and real-time kinetic monitoring of complex biological interactions. Altogether, these advances highlight the rich potential of nanoplasmonic sensors and the future growth prospects of the community as a whole. With ongoing development of commercial nanoplasmonic sensors and analytical models to interpret corresponding measurement data in the context of biologically relevant interactions, there is significant opportunity to utilize nanoplasmonic sensing strategies for not only fundamental biointerfacial science, but also translational science applications related to clinical medicine and pharmaceutical drug development among countless possibilities.
Interrobot Transformations in 3-D (2010)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> In this paper, we provide a study of motion-induced 3-D extrinsic calibration based on robot-to-robot sensor measurements. In particular, we introduce algebraic methods to compute the relative translation and rotation between two robots using known robot motion and robot-to-robot 1) distance and bearing, 2) bearing-only, and 3) distance-only measurements. We further conduct a nonlinear observability analysis and provide sufficient conditions for the 3-D relative position and orientation (pose) to become locally weakly observable. Finally, we present a nonlinear weighted least-squares estimator to refine the algebraic pose estimate in the presence of noise. We use simulations to evaluate the performance of our methods in terms of accuracy and robustness. </para>
Predictive Engineering Tools for Injection-Molded Long-Carbon-Fiber Thermoplastic Composites - FY13 Third Quarterly Report (2013)

This quarterly report summarizes the status for the project planning to obtain all the approvals required for a Cooperative Research and Development Agreement (CRADA) with Autodesk, Inc., Toyota Motor Engineering and Manufacturing North America (Toyota), and Magna Exterior and Interiors Corporation (Magna). The CRADA documents have been processed by PNNL Legal Services that is also coordinating the revision effort with the industrial parties to address DOE’s comments.
The Plasmodium falciparum PfGatp is an Endoplasmic Reticulum Membrane Protein Important for the Initial Step of Malarial Glycerolipid Synthesis (2004)

During its 48-h asexual life cycle within human erythrocytes, Plasmodium falciparum grows to many times its own size and divides to produce 16-32 new parasites. This rapid multiplication requires active synthesis of new membranes and is fueled by phospholipid precursors and fatty acids that are scavenged from the human host. Plasmodium membrane biogenesis relies heavily on the expression of parasite enzymes that incorporate these precursors into phospholipids. However, little is known about the genes involved in membrane biogenesis or where this process takes place within the parasite. Here, we describe the analysis in P. falciparum of the first step of phospholipid biosynthesis that controls acylation of glycerol 3-phosphate (GPAT) at the sn-1 position. We show that this activity is of parasite origin and is specific for glycerol 3-phosphate substrate. We have identified the gene, PfGAT, encoding this activity in P. falciparum and reconstituted its codon composition for optimal expression in the yeast Saccharomyces cerevisiae. PfGAT complements the lethality of a yeast double mutant gat1Deltagat2Delta, lacking GPAT activity. Biochemical analysis revealed that PfGatp is a low affinity GPAT enzyme with a high specificity for C16:0 and C16:1 substrates. PfGatp is an integral membrane protein of the endoplasmic reticulum expressed throughout the intraerythrocytic life cycle of the parasite but induced mainly at the trophozoite stage. This study, which describes the first protozoan GPAT gene, reveals an important role for the endoplasmic reticulum in the initial step of Plasmodium membrane biogenesis.
Detection of mixed-range proton pencil beams with a prompt gamma slit camera (2016)

With increasing availability of proton and particle therapy centers for tumor treatment, the need for in vivo range verification methods comes more into the focus. Imaging of prompt gamma rays emitted during the treatment is one of the possibilities currently under investigation. A knife-edge shaped slit camera was recently proposed for this task and measurements proved the feasibility of range deviation detection in homogeneous and inhomogeneous targets. In the present paper, we concentrate on laterally inhomogeneous materials, which lead to range mixing situations when crossed by one pencil beam: different sections of the beam have different ranges. We chose exemplative cases from clinical irradiation and assembled idealized tissue equivalent targets. One-dimensional emission profiles were obtained by measuring the prompt gamma emission with the slit camera. It could be shown that the resulting range deviations can be detected by evaluation of the measured data with a previously developed range deviation detection algorithm. The retrieved value, however, strongly depends on the target composition, and is not necessarily in direct relation to the ranges of both parts of the beam. By combining the range deviation detection with an analysis of the slope of the distal edge of the measured prompt gamma profile, the origin of the detected range deviation, i.e. the mixed range of the beam, is also identified. It could be demonstrated that range mixed prompt gamma profiles exhibit less steep distal slopes than profiles from beams traversing laterally homogeneous material. For future application of the slit camera to patient irradiation with double scattered proton beams, situations similar to the range mixing cases are present and results could possibly apply.
SC-1, a human antibody for treatment of gastric carcinomas (GCs) - Results of a multi-ethnic expression study of the SC-1 antigen (2004)

4070 Background: The human IgM antibody SC-1 binds to CD55SC-1, which is exclusively expressed on the surface of GC cells. After binding to CD55SC-1, SC-1 induces tumor specific apoptosis of GC cells in vitro and in vivo. In an academic Phase I/II trial in 51 patients with GC, SC-1 was shown to induce apoptosis and regressive effects on primary tumors. SC-1 was well tolerated and survival is higher for treated CD55SC-1positive patients as compared to CD55SC-1negative non-treated patients. In order to assess the overall proportion of GCs expressing CD55SC-1, the following study was conducted using tumor samples from patients of various ethnic groups. Lymph node metastases were also examined for CD55SC-1expression. Methods: Over 500 paraffin-fixed tissue sections from primary tumors, biopsies, and lymph node metastases from GC patients of different ethnic groups (African-American, Caucasian, Hispanic, Japanese, Asian-American, Korean) were examined by immunohistochemical staining using SC-1. All sections were examined for SC-1 staining intensity and the number of SC-1 positive cells. A score was calculated based on the percentage of positive tumor cells and staining intensity. Results: CD55SC-1 expression is found in all ethnic groups. Over 60% of tested GCs (either from diffuse or intestinal type) were reactive with the SC-1 antibody. CD55SC-1 expression on GCs ranged from 50% to 84% among the different ethnic groups analysed; over 95% of lymph node metastases were also positive for CD55SC-1. Conclusions: A large percentage of GC patients worldwide may be potential candidates for treatment with the human anti-cancer antibody SC-1, as the corresponding antigen CD55SC-1 is expressed in over 60% of all intestinal type and diffuse type GCs originating from patients from all tested ethnicities. In addition, expression in lymph node metastases may indicate a role for SC-1 treatment in metastatic GC. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration H3 Pharma, Inc.; OncoMab GmbH OncoMab GmbH OncoMab GmbH
Composite Fixation of Comminuted Ilial Wing Fractures in Cats: Three Cases (2011)

This technique provided a quick and highly adaptable means of stabilising this fracture configuration, as well as restoring pelvic symmetry, when limited buttressing support and bone stock were available cranial and ventral to the acetabulum. This method of fixation may have biomechanical advantages over lateral or dorsal plating techniques for this particular type of fracture configuration.
Targeting the integrated stress response in hematologic malignancies (2022)

While numerous targeted therapies have been recently adopted to improve the treatment of hematologic malignancies, acquired or intrinsic resistance poses a significant obstacle to their efficacy. Thus, there is increasing need to identify novel, targetable pathways to further improve therapy for these diseases. The integrated stress response is a signaling pathway activated in cancer cells in response to both dysregulated growth and metabolism, and also following exposure to many therapies that appears one such targetable pathway for improved treatment of these diseases. In this review, we discuss the role of the integrated stress response in the biology of hematologic malignancies, its critical involvement in the mechanism of action of targeted therapies, and as a target for pharmacologic modulation as a novel strategy for the treatment of hematologic malignancies.
Supplementary Table from Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance) (2023)

Supplementary Table from Plasma Protein Biomarkers in Advanced or Metastatic Colorectal Cancer Patients Receiving Chemotherapy With Bevacizumab or Cetuximab: Results from CALGB 80405 (Alliance)
Conjugate addition of methyl groups of αβ-unsaturated aldehydes: use of Me<sub>5</sub>Cu<sub>3</sub>Li<sub>2</sub> (1981)

Me5Cu3Li2 converts αβ-unsaturated aldehydes efficiently into β-methyl aldehydes and, unlike Me2CuLi, it usually gives a negligible amount of the 1,2-adduct even when a quaternary carbon is generated in the reaction.
Qsos From Large Imaging Surveys Uvas/Atlas (2018)

The u-band VST ATLAS Survey (UVAS) is the Chilean extension of the ATLAS survey. This correspond to a second observation in the u-band for the whole ATLAS survey area, effectively doubling the exposure time of the parent survey. One of the main goals of ATLAS/UVAS is the identification of a significant number of QSOs (surface density of ~100 per sq deg) to trace the BAO for cosmological applications.<br> In this work I will present our efforts to exploit ATLAS/UVAS using machine learning and deep learning algorithms, in collaboration with computer science researchers, to identify interesting samples of objects such as QSOs and strongly lensed galaxies.
Palmitoylethanolamide in Add-On to Alpha Lipoic Acid for Control of Symptoms of Diabetic Peripheral Neuropathy (2018)

Background: Palmitoylethanolamide (PEA) is an amide with “autacoid local inflammation antagonism” effects, protecting nerve degeneration due to mast cell degranulation. PEA add-on to alpha-lipoic acid (ALA) is successfully used as treatment of neuropathic pain, but there are no data in diabetic peripheral neuropathy (DPN) specifically. Aim: To evaluate whether PEA in add-on to ALA has potentials in controlling DPN symptoms. Methods: In this pilot longitudinal observational study, clinical and biochemical data from ninety-eight consecutive subjects with type 1 diabetes (T1D) evaluated for DPN symptoms between January and July 2017 in our outpatient clinic were retrospectively retrieved. DPN symptoms were assessed by Neuropathy Symptoms Score (NSS). Follow-up data were retrieved for patients with NSS ≥3 and receiving treatment with ALA 600mg/daily ± PEA 600mg/daily or receiving no treatment. Results: NSS was ≥3 in 34 (34.7%) subjects. Of these, 17 were treated with ALA ± PEA (9 with ALA in monotherapy and 8 with PEA in add-on to ALA), and 17 were not treated. After a mean follow-up of 8.1±3.4 months, NSS was ≥3 in 76.5% of non-treated subjects vs. 29.4% of treated subjects (p&amp;lt;0.01). The percentage of subjects with NSS≥3 did not differ between subjects treated with ALA vs. those treated with ALA+PEA (p=0.62). The mean time for symptoms resolution (NSS&amp;lt;3) was lower in subject treated with ALA+PEA than in those treated with ALA in monotherapy (14.0±8.6 vs. 25.0±9.1 days, p&amp;lt;0.05). Among treated subjects, baseline HDL-cholesterol was inversely related to the time to symptoms resolution (p=0.026) Conclusions: PEA add-on to ALA accelerates the resolution of neuropathic symptoms in T1D subjects with DPN. This study also suggests HDL-cholesterol may be a biomarker for the response to treatment with ALA ± PEA. Disclosure E. Maddaloni: Speaker's Bureau; Self; Merck &amp; Co., Inc.. Research Support; Self; European Foundation for the Study of Diabetes. A. Maurizi: None. A. Minutolo: None. E. Fioriti: None. R. Del Toro: None. A. Naciu: None. S. Pieralice: None. M.M. Rosati: None. S. Manfrini: None. P. Pozzilli: Research Support; Self; Sanofi. Speaker's Bureau; Self; Eli Lilly and Company. Research Support; Self; Merck Sharp &amp; Dohme Corp..
Achievable Degrees of Freedom of the K-user Interference Channel with Partial Cooperation (2011)

In this paper, we consider the K-user interference channel with partial cooperation, where a strict subset of the K users cooperate. For the K-user interference channel with cooperating subsets of length M, the outer bound of the total degrees of freedom is KM/(M+1). In this paper, we propose a signal space-based interference alignment scheme that proves the achievability of these degrees of freedom for the case K=M+2. The proposed scheme consists of a design for the transmit precoding matrices and a processing algorithm which we call the Successive Interference Alignment (SIA) algorithm. The decoder of each message uses the SIA algorithm to process the signals received by the M cooperating receivers in order to get the maximum available degrees of freedom.
Supplementary Figure 1 from Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis (2023)

Supplementary Figure 1 from Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis
Topographic profiling and refractive-index analysis by use of differential interference contrast with bright-field intensity and atomic force imaging (2004)

A methodology is described for phase restoration of an object function from differential interference contrast (DIC) images. The methodology involves collecting a set of DIC images in the same plane with different bias retardation between the two illuminating light components produced by a Wollaston prism. These images, together with one conventional bright-field image, allows for reduction of the phase deconvolution restoration problem from a highly complex nonlinear mathematical formulation to a set of linear equations that can be applied to resolve the phase for images with a relatively large number of pixels. Additionally, under certain conditions, an on-line atomic force imaging system that does not interfere with the standard DIC illumination modes resolves uncertainties in large topographical variations that generally lead to a basic problem in DIC imaging, i.e., phase unwrapping. Furthermore, the availability of confocal detection allows for a three-dimensional reconstruction with high accuracy of the refractive-index measurement of the object that is to be imaged. This has been applied to reconstruction of the refractive index of an arrayed waveguide in a region in which a defect in the sample is present. The results of this paper highlight the synergism of far-field microscopies integrated with scanned probe microscopies and restoration algorithms for phase reconstruction.
Method Development Workflow for Quantifying Protein Biomarkers by Hybrid LC–MS/MS (2022)

<b>Background:</b> Industry-standard guidance on method development and validation of hybrid LC-MS/MS assays for protein biomarkers, particularly on evaluation of parallelism, is lacking. <b>Methods:</b> Using a protein endogenous to humans and mice as a model analyte, a quantitative hybrid LC-MS/MS workflow was developed using a surrogate matrix approach with a recombinant form of the protein as the calibrant. <b>Results:</b> The developed workflow identified a surrogate matrix, established parallelism between the surrogate and authentic matrices and assessed parallelism between the recombinant and authentic forms of the protein. The final method was qualified using precision and accuracy with recovery assessments. <b>Conclusion:</b> The established workflow can be used in future bioanalytical studies to develop effective hybrid LC-MS/MS methods for endogenous protein biomarkers.
Numerical analysis of a reactive extrusion process. Part II: Simulations and verifications for the twin screw extrusion (2000)

Abstract A newly designed extruder reactor for grafting vinyl monomers onto polyolefins was studied experimentally and theoretically. The process was made up of a self‐wiping co‐rotating twin screw extruder with a separated reaction zone and two vent zones. The reactive extrusion was performed using a linear low density polyethylene, vinyltrimethoxysilane and di‐t‐butylperoxide under different operation conditions. For the purpose of process analysis, we built a computer simulation based on the reaction kinetics and rheological models studied in the preceding paper. The flow field in the extruder was calculated by the flow analysis network (FAN) method with non‐isothermal non‐Newtonian flow conditions. The iterative procedure was organized to predict local pressure, filling factor, cumulative residence time and temperature along the extruder. Furthermore, we succeeded in representing the profiles of reaction conversion and shear viscosity. Calculated results showed good agreements with the experimental data.
Effect of corticosteroids on 18F-FDG uptake in tumor lesions after chemotherapy. (2007)

After corticosteroid administration, the contribution of inflammatory cells to the (18)F-FDG uptake was less important than that in mice treated with chemotherapy alone. The earlier, but weaker, inflammatory response after corticosteroid administration consists primarily of granulocytes instead of mononuclear cells.
Infection of Mosquitoes with Plasmodium falciparum by Feeding on Humans and on Aotus Monkeys (2009)

Of 1,004 positive lots of mosquitoes fed on 229 humans infected with Plasmodium falciparum, 46.2% had 1-10 oocysts/(+)gut, 21.2% had 10-30 oocysts/(+)gut, 22.2% had 30-100 oocysts/(+)gut, and 10.4% had > 100 oocysts/(+) gut. The highest levels of infection occurred between 6 and 15 days after the peak in the asexual parasite count. Of 2,281 lots of Anopheles freeborni mosquitoes fed on splenectomized Aotus monkeys infected with the Santa Lucia strain of P. falciparum, 1,191 were infected (52.2%). The highest intensity infections ranged from 2.78 oocysts per positive gut in mosquitoes fed on Aotus vociferans to 6.08 oocysts per positive gut for those fed on A. lemurinus griseimembra to 10.4 oocysts per positive gut for those fed on A. nancymaae. The pattern of infection for mosquitoes fed on splenectomized Aotus monkeys was similar to that obtained by feeding on humans, but the intensity, based on oocyst/(+)gut, was much lower.