gebhart/patrepeval huggingface dataset:
A germanate transparent conductive oxide (2011)

Wide bandgap conductors such as In₂O₃ and ZnO are used as transparent conducting oxides (TCOs). To date, TCOs are realized using post transition metal cations with largely spread s-orbitals such as In³⁺, Sn⁴⁺, Zn²⁺ and Cd²⁺. On the other hand, no good electronic conductor has been realized in oxides of Al, Si and Ge. Here we report the conversion of an oxide of Ge into a good electronic conductor by employing the concept of superdegeneracy. We find that cubic SrGeO₃, synthesized under high pressure, displays a direct bandgap of 3.5 eV, a carrier mobility of 12 cm²(Vs)⁻¹, and conductivities of 3 Scm⁻¹ (DC) and 400 Scm⁻¹ (optical conductivity). This is the first Ge-based electronic conductive oxide, and expands the family of TCOs from ionic oxides to covalent oxides.
Thermo-Magnetic, Piezo-Electric and Electroactive Energy Harvesting Devices. (2009)

International audience
Combining cooperative link layer protocols with distributed routing protocols in mobile ad hoc networks – perspectives and performance analysis (2013)

Abstract — In cooperative link layer protocols the use of relay nodes may increase the capacity of the radio links. The study in this paper investigates what (if any) performance gain may be passed onto the routing protocol of a mobile ad hoc network. Two popular routing protocols are considered, AODV and OLSR, as each provides a unique route acquisition mechanism. A distributed procedure to choose the relay node at the link layer is combined with the two routing protocols. Analysis via simulation confirms some expected (and perhaps some other less expected) benefits when using a cooperative link layer protocol in place of a non-cooperative one, e.g., improved delivery ratio, end-to-end delay, and reduced signaling overhead. I.
Secondary Mutation Maintains the Transformed State in BaF3 Cells With Inducible BCR/ABL Expression (1998)

The BCR/ABL gene product of the Philadelphia (Ph) chromosome induces chronic myelogenous leukemia (CML). We generated a hematopoietic cell line, TonB210.1, with tetracycline-dependent BCR/ABL expression to investigate the pathways by which BCR/ABL transforms cells. TonB210.1 demonstrates conditional growth factor independence in tissue culture and rapidly forms tumors in mice fed the tetracycline analog doxycycline. The tumors regress completely upon doxycycline withdrawal, but ultimately reform in all animals. After a long latency, tumors also develop in animals never exposed to doxycycline. Subclones of TonB210.1 established from doxycycline-independent tumors demonstrate distinct mechanisms of transformation. Most subclones manifest increased basal levels of BCR/ABL expression; some have lost the capacity to augment expression upon induction, whereas others remain inducible. More interestingly, some subclones maintain tight conditional expression of BCR/ABL and are therefore transformed by secondary mechanisms that no longer require BCR/ABL expression. These subclones show constitutive phosphorylation of the STAT5 protein, suggesting that activating mutations have occurred upstream in the signaling pathway to STAT5. The tight conditional expression of BCR/ABL in the TonB210.1 cell line affords the opportunity to study several interesting aspects of the biology of BCR/ABL, including activation of critical signaling pathways and transcriptional programs, and its potential role in genomic instability.
A facile and chemoselective synthesis of 1,4-benzodiazepin-2-ones and dienyl thiazolidin-4-ones (2016)

A chemoselective synthesis of novel 1,4-benzodiazepin-2-ones and dienyl thiazolidin-4-one carboxylates in excellent yields by ring transformation reactions of functionally decorated 2-azetidin-3-thiazolidin-4-ones is reported.
Application of Phosphorescence Measurement outside Aerospace Field (2018)

本稿は，燃料電池，自然，生体など航空宇宙以外の分野における感圧塗料（りん光色素）の応用について，概説する．航空宇宙以外の分野，特に，燃料電池セル内の流れ，ターボ機械内部流れ場，海底などの堆積物断面の酸素濃度，医療応用，細胞内の酸素濃度など分野を超えた様々な応用範囲について取り上げた．本稿により，感圧塗料が様々な分野へ適応可能であることが読者に紹介できれば幸いである．
Template-Controlled Synthesis of Wire-Like Cadmium Sulfide Nanoparticle Assemblies within Core−Shell Cylindrical Polymer Brushes (2004)

A controlled fabrication of wire-like assemblies of cadmium sulfide (CdS) nanoparticles has been developed based on a template technique. Well-defined amphiphilic core−shell cylindrical polymer brushes were used as single molecule templates, utilizing the coordination of cadmium ions with carboxylate groups in the core of the brush. Formation of CdS nanoparticles inside the polymer brush was carried out via the reaction of the coordinated Cd2+ ions with H2S. This route resulted in wire-like CdS nanoparticle assemblies of about 4−5 nm in diameter and about 170 nm long. After the formation of the CdS nanoparticles, the polymer brush resumes its original chemical structure and morphology and therefore can be used as template again. The obtained polymer−semiconductor nanocomposite is soluble and stable in organic solvents, and potential applications may be found due to the quasi-1D structure of the assembly of CdS nanoparticles. In principle, the present synthetic approach is of general applicability to various metals, metal chalcogenides, and oxides.
Lossy compression with a short processing block: Asymptotic analysis (2014)

Finite-blocklength analysis of lossy compression can have a variety of different motivations. First, the source sequence itself may be short. Second, delay and complexity constraints may require processing of short source blocks. And finally, user experience may require low distortion when averaging over short blocks, which we term fidelity blocks. Existing work on the subject has largely coupled these issues, i.e., a source block is compressed taking into account the statistics of the distortion averaged over that block (usually the excess-distortion probability). For short source sequences, this coupling indeed makes sense. In this work, however, we instead consider the case of a long source sequence, whose compression performance is set by the interplay between the comparatively shorter processing and fidelity blocklengths. We focus on asymptotic analysis of the excess rate needed to ensure a given excess-distortion probability, for processing blocks that are shorter than the fidelity ones. Our main result is that the second-order performance (dispersion) is relatively unaffected by choosing a processing blocklength considerably shorter than the fidelity blocklength. Thus, one may use lower dimensional quantizers than existing work would otherwise suggest without sacrificing significant performance.
PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the <i>N</i> -methyl- <scp>d</scp> -aspartate receptor subunit NR2A (1999)

Fyn, a member of the Src-family protein-tyrosine kinase (PTK), is implicated in learning and memory that involves N-methyl-D-aspartate (NMDA) receptor function. In this study, we examined how Fyn participates in synaptic plasticity by analyzing the physical and functional interaction between Fyn and NMDA receptors. Results showed that tyrosine phosphorylation of NR2A, one of the NMDA receptor subunits, was reduced in fyn-mutant mice. NR2A was tyrosine-phosphorylated in 293T cells when coexpressed with Fyn. Therefore, NR2A would be a substrate for Fyn in vivo. Results also showed that PSD-95, which directly binds to and coclusters with NMDA receptors, promotes Fyn-mediated tyrosine phosphorylation of NR2A. Different regions of PSD-95 associated with NR2A and Fyn, respectively, and so PSD-95 could mediate complex formation of Fyn with NR2A. PSD-95 also associated with other Src-family PTKs, Src, Yes, and Lyn. These results suggest that PSD-95 is critical for regulation of NMDA receptor activity by Fyn and other Src-family PTKs, serving as a molecular scaffold for anchoring these PTKs to NR2A.
Immunological Detection of Phosphorylation (1998)

Incorporation of phosphates into serine, threonine, and tyrosine acceptors in proteins is a common mechanism for regulating protein function. This unit presents protocols that use specific anti-phosphoamino acid (PAA) and anti-phosphoprotein antibodies to detect protein phosphorylation and protein kinase activity. Immunoblotting to detect protein phosphorylation using either anti-PAA or anti-phosphoprotein antibodies. This is a convenient method that usually yields impressive results. Phosphorylation can also be detected by immunoprecipitation followed by immunoblot analysis or by immunofluorescent staining; these methods are typically more complicated and time consuming. All three methods have been successfully used to detect protein phosphorylation with a wide variety of antibodies and most phosphorylated proteins.
Haptic feedback in eye typing (2016)

Proper feedback is essential in gaze based interfaces, where the same modality is used for both perception and control. We measured how vibrotactile feedback, a form of haptic feedback, compares with the commonly used visual and auditory feedback in eye typing. Haptic feedback was found to produce results that are close to those of auditory feedback; both were easy to perceive and participants liked both the auditory ”click” and the tactile “tap” of the selected key. Implementation details (such as the placement of the haptic actuator) were also found important.
Abstract IA08: Identifying and overcoming metabolic checkpoints to antitumor immunity (2016)

Abstract It has now become clear that the immune system is not oblivious to cancer initiation and progression, but rather is rendered dysfunctional through a wide array of tolerogenic mechanisms. One of these is the generation of a potently immunosuppressive microenvironment, characterized by altered populations of suppressive cells, secretion of suppressive cytokines, and upregulation of inhibitory ligands. The tumor microenvironment also possesses, due to the deregulated energetics of cancer cells, an altered metabolic profile: hypoxia, acidosis, and a dearth of glucose and other carbon sources. T cell activation and effector function are metabolically demanding, requiring elevated glucose processing and mitochondrial activity to keep up with the bioenergetic demands of proliferation, cytokine secretion, and cytolytic capacity. Thus, we sought to determine whether the metabolism of the tumor microenvironment acts as a barrier to antitumor immunity and resistance mechanism to immunotherapy. We have demonstrated that T cells infiltrating murine and human tumors exhibit a phenotype of metabolic insufficiency, characterized by decreased glucose uptake and a crippling loss of mitochondrial function. We show that this loss of oxidative function is specific to the chronic activation observed in the tumor microenvironment, and occurs rapidly upon entry into the tumor. This loss of mitochondrial activity and mass is due, in part, to the repression of PGC1α, a transcriptional co-activator that programs mitochondrial biogenesis. Further, we have identified chronic Akt activation and consequent Foxo inactivation as a major driver of PGC1α repression. Importantly, metabolic reprogramming of tumor-specific T cells to enforce mitochondrial biogenesis results in dramatically increased antitumor immunity, characterized by robust proliferation, cytokine production, and tumor regression and clearance. Our data support a model in which mitochondrial insufficiency represents a primordial checkpoint inhibiting antitumor immunity in addition to immunologic suppression. Further supporting this notion are additional studies from our laboratory suggesting that selective boosting of T cell mitochondrial activity through mitigation of tumor hypoxia dramatically enhances immunotherapies like checkpoint blockade and adoptive cell therapy. Our data suggest not only that the metabolic nature of the tumor microenvironment may be predictive of a patient's response to various immunotherapies, but that metabolic reprogramming of T cells or the microenvironment itself may be an important means to improve the immunotherapeutic treatment of cancer. Citation Format: Greg M. Delgoffe. Identifying and overcoming metabolic checkpoints to antitumor immunity [abstract]. In: Proceedings of the Second CRI-CIMT-EATI-AACR International Cancer Immunotherapy Conference: Translating Science into Survival; 2016 Sept 25-28; New York, NY. Philadelphia (PA): AACR; Cancer Immunol Res 2016;4(11 Suppl):Abstract nr IA08.
To React or not to React: End-to-End Visual Pose Forecasting for\n Personalized Avatar during Dyadic Conversations (2019)

Non verbal behaviours such as gestures, facial expressions, body posture, and\npara-linguistic cues have been shown to complement or clarify verbal messages.\nHence to improve telepresence, in form of an avatar, it is important to model\nthese behaviours, especially in dyadic interactions. Creating such personalized\navatars not only requires to model intrapersonal dynamics between a avatar's\nspeech and their body pose, but it also needs to model interpersonal dynamics\nwith the interlocutor present in the conversation. In this paper, we introduce\na neural architecture named Dyadic Residual-Attention Model (DRAM), which\nintegrates intrapersonal (monadic) and interpersonal (dyadic) dynamics using\nselective attention to generate sequences of body pose conditioned on audio and\nbody pose of the interlocutor and audio of the human operating the avatar. We\nevaluate our proposed model on dyadic conversational data consisting of pose\nand audio of both participants, confirming the importance of adaptive attention\nbetween monadic and dyadic dynamics when predicting avatar pose. We also\nconduct a user study to analyze judgments of human observers. Our results\nconfirm that the generated body pose is more natural, models intrapersonal\ndynamics and interpersonal dynamics better than non-adaptive monadic/dyadic\nmodels.\n
Ciprofloxacin-Loaded Mixed Polymeric Micelles as Antibiofilm Agents (2023)

In this work, mixed polymeric micelles (MPMs) based on a cationic poly(2-(dimethylamino)ethyl methacrylate)-b-poly(ε-caprolactone)-b-poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA<sub>29</sub>-b-PCL<sub>70</sub>-b-PDMAEMA<sub>29</sub>) and a non-ionic poly(ethylene oxide)-b-poly(propylene oxide)-b-poly(ethylene oxide) (PEO<sub>99</sub>-b-PPO<sub>67</sub>-b-PEO<sub>99</sub>) triblock copolymers, blended at different molar ratios, were developed. The key physicochemical parameters of MPMs, including size, size distribution, and critical micellar concentration (CMC), were evaluated. The resulting MPMs are nanoscopic with a hydrodynamic diameter of around 35 nm, and the ζ-potential and CMC values strongly depend on the MPM's composition. Ciprofloxacin (CF) was solubilized by the micelles via hydrophobic interaction with the micellar core and electrostatic interaction between the polycationic blocks, and the drug localized it, to some extent, in the micellar corona. The effect of a polymer-to-drug mass ratio on the drug-loading content (DLC) and encapsulation efficiency (EE) of MPMs was assessed. MPMs prepared at a polymer-to-drug mass ratio of 10:1 exhibited very high EE and a prolonged release profile. All micellar systems demonstrated their capability to detach pre-formed Gram-positive and Gram-negative bacterial biofilms and significantly reduced their biomass. The metabolic activity of the biofilm was strongly suppressed by the CF-loaded MPMs indicating the successful drug delivery and release. The cytotoxicity of empty and CF-loaded MPMs was evaluated. The test reveals composition-dependent cell viability without cell destruction or morphological signs of cell death.
Rationale Based Selection and Prioritization of Antiviral Drugs for COVID-19 Management (2020)

Infection with SARS-CoV-2 has resulted in COVID-19 pandemic and infected more than 5million individuals with around 0.35 million deaths worldwide till May 2020 end. Severalefforts are on in search of therapeutic interventions, but the preferred way is drugrepurposing due to the feasibility and urgency of the situation. To select and prioritizeapproved antiviral drugs and drug combinations for COVID-19, 61 antiviral drugs havingproven safety profile in humans were subjected to virtual screening for binding to threeselect targets namely human angiotensin-converting enzyme receptor-2 receptor-bindingdomain (hACE-2) involved in virus entry, SARS-CoV-2 RNA dependent RNA polymerase(RdRp) responsible for viral RNA replication and SARS-CoV-2 main protease (MPro) causingproteolytic processing of viral polyprotein slab. Targeting multiple ‘disease pathogenesisspecific proteins’ within a close network of interaction or having dependent functionality canprovide effective intervention. Ledipasvir, Daclatasvir, Elbasvir, Paritaprevir, Rilpivirine andIndinavir were identified as candidate drugs of interest for COVID-19 based on a derivedcombined activity score, pharmacokinetic and pharmacodynamic parameters. Ledipasvir andDaclatasvir and their approved marketed combination with Sofosbuvir emerged as leadingcandidate drugs/drug combinations for SARS-CoV-2. These candidates have the potentialfor the antiviral activity for SARS-CoV-2 infection better than the investigational drugRemdesivir and other antiviral drugs/drug combinations being evaluated. Thesedrugs/combinations merit systematic fast track preclinical and clinical evaluation for COVID-19 management. The present work brings back attention to the potential usefulness ofapproved antiviral drugs/drug combinations, commonly available with established safetyprofile, currently not in focus for COVID-19. It provides a rationale based approach for theselection of drugs with potential antiviral activity against SARS-CoV-2 highlighting thedesired properties.
Diagnostic and prognostic markers in infants with disseminated neuroblastoma: a retrospective analysis from the Italian Cooperative Group for Neuroblastoma. (2009)

The frequency of stage 4s was greater than stage 4. MYCN amplification was the most unfavorable prognostic factor. Survival was similar to previous series, confirming that a part of such infants cannot be cured by current therapies.
Neuronal Complexity in Subthalamic Nucleus is Reduced in Parkinson’s Disease (2015)

Several theories posit increased Subthalamic Nucleus (STN) activity is causal to Parkinsonism, yet in our previous study we showed that activity from 113 STN neurons from two epilepsy patients and 103 neurons from nine Parkinson's disease (PD) patients demonstrated no significant differences in frequencies or in the coefficients of variation of mean discharge frequencies per 1-s epochs. We continued our analysis using point process modeling to capture higher order temporal dynamics; in particular, bursting, beta-band oscillations, excitatory and inhibitory ensemble interactions, and neuronal complexity. We used this analysis as input to a logistic regression classifier and were able to differentiate between PD and epilepsy neurons with an accuracy of 92%. We also found neuronal complexity, i.e., the number of states in a neuron's point process model, and inhibitory ensemble dynamics, which can be interpreted as a reduction in complexity, to be the most important features with respect to classification accuracy. Even in a dataset with no significant differences in firing rate, we observed differences between PD and epilepsy for other single-neuron measures. Our results suggest PD comes with a reduction in neuronal "complexity," which translates to a neuron's ability to encode information; the more complexity, the more information the neuron can encode. This is also consistent with studies correlating disease to loss of variability in neuronal activity, as the lower the complexity, the less variability.
Parasitic series resistance-independent method for device-model parameter extraction (1996)

A new method is presented that permits the extraction of a semiconductor device&apos;s intrinsic model parameters from its experimental extrinsic forward I–V characteristics, independently of the parasitic resistance that might be present in series within the real device. The extraction is performed from an auxiliary function which contains the integral of the experimentally measured data. Integrating the data also serves as a smoothing procedure. The diode quality factor, reverse current and series resistance parameters of a single exponential diode model are extracted from a real p-n junction diode in order to illustrate the method.
Utilization of the Hookword Method for the Learning of Polish Vocabulary : A Personal Investigation (1989)

The hookword method of learning foreign language vocabulary evolved by Paivio (1978) is far less widely known than the keyword method of Pressley and his associates and has been subject to very little experimantation. Furthermore, althought intended as a rehearsal and learning technique to be used by any individual learner independently of a teacher and any material constraints, virtually no attempt bas been made to implement it.
Originally developed for the learning of French vocabulary, the system was adapted by the author for use with Polish. Following a description of the method, it is shown how this adaptation was accomplished. A number of positive and neutral observations are listed which were recorded over the twelve-month period in which it was amployed; drawbacks of the method are then described and discussed.
The overall experience was positive in so far as it gave insights into the potential of imagery as a memory and learning aid and in that it substantially augmented and reinforced the author's Polish lexis at no cost to any other activity
Human Natural Killer Receptors, Co‐Receptors, and Their Ligands (2009)

In the last 20 years, the study of human natural killer (NK) cells has moved from the first molecular characterizations of very few receptor molecules to the identification of a plethora of receptors displaying surprisingly divergent functions. We have contributed to the description of inhibitory receptors and their signaling pathways, important in fine regulation in many cell types, but unknown until their discovery in the NK cells. Inhibitory function is central to regulating NK-mediated cytolysis, with different molecular structures evolving during speciation to assure its persistence. More recently, it has become possible to characterize the NK triggering receptors mediating natural cytotoxicity, unveiling the existence of a network of cellular interactions between effectors of both natural and adaptive immunity. This unit reviews the contemporary history of molecular studies of receptors and ligands involved in NK cell function, characterizing the ligands of the triggering receptor and the mechanisms for finely regulating their expression in pathogen-infected or tumor cells. © 2018 by John Wiley & Sons, Inc.
Placental anomalies in IVF pregnancies: preliminary report of a multicentric study (1986)

info:eu-repo/semantics/nonPublished