gebhart/patrepeval huggingface dataset:
Sulfoximine Assisted C–H Activation and Annulation via Vinylene Transfer: Access to Unsubstituted Benzothiazines (2023)

In this study, we report the synthesis of unsubstituted 1,2-benzothiazines through a redox-neutral Rh(III)-catalyzed C-H activation and [4+2]-annulation of S-aryl sulfoximines with vinylene carbonate. Notably, the introduction of an N-protected amino acid ligand significantly enhances the reaction rate. The key aspect of this redox-neutral process is the utilization of vinylene carbonate as an oxidizing acetylene surrogate and an efficient vinylene transfer agent. This vinylene carbonate enables the cyclization with the sulfoximine motifs, successfully forming a diverse array of 1,2-benzothiazine derivatives in moderate to good yields. Importantly, this study highlights the potential of Rh(III)-catalyzed C-H activation and [4+2]-annulation reactions for the synthesis of optically pure 1,2-benzothiazines with high enantiomeric purity.
&lt;title&gt;Tomographic imaging of radar data gathered on a circular flight path about a three-dimensional target zone&lt;/title&gt; (1995)

We have coded a tomographic-style algorithm that is capable of imaging radar data obtained on a circular flight path about a 3D target zone. Our imaging algorithm is designed to image field data collected with Mireage's new Subsurface Imaging Synthetic Aperture Radar (SISAR), a ground-penetrating device operating in the spotlight mode. The SISAR algorithm operates on radar data gathered in (or converted to) the range-azimuth domain--the so-called sinogram plane. On the sinogram plane, the impulse response of a point scatterer is sinewave- shaped curve. The amplitude of the sinewave is related to the target's radial coordinate, its phase to the target's azimuthal coordinate, and its bias to the target's burial depth. When flown on a circular path about a 3D target zone, SISAR generates 3D-style sinograms. Our imaging algorithm produces 3D maps of the target zone by converting each sinewave trace on the sinogram plane to a delta function in three-space. The code is fast (in the FFT sense). Moreover, it avoids the laborious, and often inaccurate conversion of the collected radar data from cylindrical coordinates to rectangular ones, as in conventional radar imaging.
Xatu (2022)

The performance of Adaptive Bitrate (ABR) algorithms for video streaming depends on accurately predicting the download time of video chunks. Existing prediction approaches (i) assume chunk download times are dominated by network throughput; and (ii) apriori cluster sessions (e.g., based on ISP and CDN) and only learn from sessions in the same cluster. We make three contributions. First, through analysis of data from real-world video streaming sessions, we show (i) apriori clustering prevents learning from related clusters; and (ii) factors such as the Time to First Byte (TTFB) are key components of chunk download times but not easily incorporated into existing prediction approaches. Second, we propose Xatu, a new prediction approach that jointly learns a neural network sequence model with an interpretable automatic session clustering method. Xatu learns clustering rules across all sessions it deems relevant, and models sequences with multiple chunk-dependent features (e.g., TTFB) rather than just throughput. Third, evaluations using the above datasets and emulation experiments show that Xatu significantly improves prediction accuracies by 23.8% relative to CS2P (a state-of-the-art predictor). We show Xatu provides substantial performance benefits when integrated with multiple ABR algorithms including MPC (a well studied ABR algorithm), and FuguABR (a recent algorithm using stochastic control) relative to their default predictors (CS2P and a fully connected neural network respectively). Further, Xatu combined with MPC outperforms Pensieve, an ABR based on deep reinforcement learning.
A phase II study evaluating safety and efficacy of niraparib in patients with previously treated homologous recombination (HR) defective or loss of heterozygosity (LOH) high-metastatic esophageal/GEJ/proximal gastric adenocarcinoma: A Big Ten Cancer Research Consortium study. (2020)

TPS472 Background: Adenocarcinoma of esophagus (EAC) and GEJ is the fastest rising cancer in the US. The outcomes are extremely poor with median overall survival (OS) being 12 mo in patients (pts) with metastatic disease. The standard first line treatment for metastatic EAC is platinum-based regimen with median progression free survival (PFS) of 6 mo. Second line options are associated with limited efficacy. An analysis of TCGA has shown 40% of EAC harboring abnormalities in HR genes, most likely resulting from chronic acid reflux induced DNA damage. HR dysregulation is commonly associated with high LOH. Sensitivity to PARP inhibition has been shown to be a surrogate for HR defects or BRCAness phenotype. Clinically PARP inhibitors have shown activity in HR defective prostate and ovarian cancers. These findings provide the basis for this study. Methods: Pts with metastatic esophageal/GEJ/proximal gastric adenocarcinoma, previously treated with 1 line of platinum containing chemotherapy, and harboring high LOH and/or deleterious alteration(s) in HR genes ( BRCA1/2, PALB2, ATM, BARD1, BRIP1, CDK12, CHEK2, FANCA, RAD51, RAD51B, RAD51C, RAD51D, RAD54L, NBN, ARID1A, GEN1) are eligible for this study. Pts can be prescreened at the time of diagnosis of locally advanced or metastatic disease by genomic analysis of the most recent available tumor tissue. Pts will receive oral niraparib until disease progression or unacceptable toxicity. Primary objective is response rate (RR). Secondary objectives are safety and tolerability, progression free survival (PFS), and disease control rate (DCR). Exploratory objectives include correlation between high LOH and response to niraparib, mechanisms of resistance to PARP inhibition, EZH2 expression and its correlation with response and resistance to PARP inhibition, and analysis of germline HR gene mutations and correlation with response to niraparib. Estimated sample size is 43. The study has recently opened to accrual at Indiana University with intended collaboration with 2 additional sites. Clinical trial information: NCT03840967.
Difference in Th1 and Th17 Lymphocyte Adhesion to Endothelium (2011)

T cell subset-specific migration to inflammatory sites is tightly regulated and involves interaction of the T cells with the endothelium. Th17 cells often appear at different inflammatory sites than Th1 cells, or both subsets appear at the same sites but at different times. Differences in T cell subset adhesion to endothelium may contribute to subset-specific migratory behavior, but this possibility has not been well studied. We examined the adhesion of mouse Th17 cells to endothelial adhesion molecules and endothelium under flow in vitro and to microvessels in vivo and we characterized their migratory phenotype by flow cytometry and quantitative RT-PCR. More Th17 than Th1 cells interacted with E-selectin. Fewer Th17 than Th1 cells bound to TNF-α-activated E-selectin-deficient endothelial cells, and intravital microscopy studies demonstrated that Th17 cells engage in more rolling interactions with TNF-α-treated microvessels than Th1 cells in wild-type mice but not in E-selectin-deficient mice. Th17 adhesion to ICAM-1 was dependent on integrin activation by CCL20, the ligand for CCR6, which is highly expressed by Th17 cells. In an air pouch model of inflammation, CCL20 triggered recruitment of Th17 but not Th1 cells. These data provide evidence that E-selectin- and ICAM-1-dependent adhesion of Th17 and Th1 cells with endothelium are quantitatively different.
Solar blind chemically vapor deposited diamond detectors for vacuum ultraviolet pulsed light-source characterization (1998)

A major difficulty in characterizing vacuum ultraviolet (VUV) radiation produced by harmonic generation or four-wave sum frequency mixing arises in differentiating between the desired VUV signal and the remaining fundamental pump laser beam. To overcome this problem, visible and near UV blind VUV detectors, made from natural and synthetic diamond, have been developed. Such detectors have been used to characterize coherent VUV pulses (λ=125 nm, pulse duration at full width half maximum (FWHM) τFWHM∼7 ns) generated by resonance-enhanced four-wave sum mixing in mercury vapor. They allow full characterization of the intensity profile of the VUV pulses, without any significant parasitic signal from simultaneous stray light irradiation at λ=313 nm. Detectors were fabricated exhibiting response times of less than 70 ps at FWHM, corresponding to the lowest response time obtainable with a 7 GHz bandwidth single-shot oscilloscope.
Complement and disease: better no factor H than bad factor H (2017)

Within just a few minutes the complement system (1) can label a foreign cell that has invaded the bloodstream with millions of copies of C3b. Destruction or clearance of the C3b-coated invader quickly follows. C3b is the activated cleavage product of C3, an abundant serum protein. Numerous diseases have been linked to collateral damage from this aggressive process (2). Recently, Ueda et al . (3) presented a striking example of a mouse model, based on a single amino-acid replacement, in which uncontrolled C3b deposition on host tissue led to renal failure, stroke and retinopathy.
When2com: Multi-Agent Perception via Communication Graph Grouping (2020)

While significant advances have been made for single-agent perception, many applications require multiple sensing agents and cross-agent communication due to benefits such as coverage and robustness. It is therefore critical to develop frameworks which support multi-agent collaborative perception in a distributed and bandwidth-efficient manner. In this paper, we address the collaborative perception problem, where one agent is required to perform a perception task and can communicate and share information with other agents on the same task. Specifically, we propose a communication framework by learning both to construct communication groups and decide when to communicate. We demonstrate the generalizability of our framework on two different perception tasks and show that it significantly reduces communication bandwidth while maintaining superior performance.
Initiation and failure mechanism of base instability of excavations in clay triggered by hydraulic uplift (2014)

Excavations in clay overlying an aquifer may cause catastrophic basal failure due to hydraulic uplift. Although case histories with hydraulic uplift failures are reported worldwide from time to time, the initiation and failure mechanism of the base instability are not well studied and understood. To address these two issues, dimensional analysis is firstly conducted to propose dimensionless groups (DGs) possibly relevant to this subject. Effects of these DGs on the initiation and failure mechanism of base instability are then investigated, by carrying out a series of finite element analyses, in which constitutive models and model parameters have been previously validated against centrifuge test results. It is revealed that the initiation and failure mechanism of base instability due to hydraulic uplift is mainly governed by a ratio of excavation width over the thickness of soft clay inside excavation (B/D). As excavation becomes narrower (i.e., B/D decreases), the hydraulic pressure (P i ) required to initiate uplift movement of clay inside excavation increases significantly (maximum percentage increase = 50%), due to increased effect of downward shear stress acting along soil–wall interface on basal resistance. Based on the parametric study, a calculation chart is developed for estimating P i of excavations with varied B/D and undrained shear strength of clay. At basal failure caused by hydraulic uplift, the dominant failure mode changes from simple shear in relatively narrow excavations (i.e., B/D &lt; 4) to combined modes of triaxial compression, triaxial extension, and simple shear in relatively wide excavations (i.e., B/D &gt; 4).
Th17 Cells and Activated Dendritic Cells Are Increased in Vitiligo Lesions (2011)

Background: Vitiligo is a common skin disorder, characterized by progressive skin de-pigmentation due to the loss of cutaneous melanocytes. The exact cause of melanocyte loss remains unclear, but a large number of observations have pointed to the important role of cellular immunity in vitiligo pathogenesis.
A 60 GHz 14 dBm power amplifier with a transformer-based power combiner in 65 nm CMOS (2011)

A 52–61 GHz power amplifier (PA) is implemented in 65 nm bulk complementary metal oxide semiconductor (CMOS) technology. The proposed PA employs a transformer-based power combiner to sum the output power from two unit PAs. Each unit PA uses transformer-coupled two-stage differential cascode topology. The differential cascode PA is able to increase the output power and ensure stability. The transformer-based passives enable a compact layout with the PA core area of only 0.3 mm 2 . The PA achieves a peak power gain of 10.2 dB with 3-dB bandwidth of 9 GHz. The measured saturated output power is 14.8 dBm with a peak power-added efficiency (PAE) of 7.2%. The reverse isolation is smaller than −33 dB from 25 to 65 GHz. The PA consumes a quiescent current of 143 mA from a 1.6 V supply.
Abstract B5: CpG-siRNA conjugates: Overcoming cancer immunoresistance (2012)

Abstract Small interfering RNA (siRNA) have been proved to be an effective tool for treating diseases caused by gene expression abnormalities. However, clinical relevance of siRNA technology is compromised by multiple obstacles, such as lack of cellular specificity, low efficiency of cellular uptake and/or poor cytoplasmic release. We have previously demonstrated that natural capability of certain immune cells to recognize non-methylated CpG motifs in DNA oligonucleotides can be harnessed for cell-specific siRNA delivery. The siRNA molecules conjugated to CpG oligonucleotides (CpG-siRNA) are efficiently internalized and bind to the intracellular Toll-like receptor 9 (TLR9) in human and mouse dendritic cells as well as in certain TLR9-positive tumor cells. We designed a CpG-siRNA targeting Stat3 (signal transducer and activator of transcription-3), a transcription factor, which is constitutively activated in majority of mouse and human cancers. Oncogenic Stat3 signaling regulates cancer cell proliferation, survival and promotes tumor immunoresistance. We have previously shown that CpG-Stat3 siRNA can eliminate Stat3 signaling in tumor-infiltrating myeloid cells, resulting in potent antitumor immunity. In the current study, we investigated the intracellular mechanism of action of CpG-siRNA conjugates. We have demonstrated that internalized CpG-siRNAs are recruited into endosomes by dynamin-dependent mechanism and bind to endosomal TLR9 receptor. Further events include uncoupling of siRNA from the CpG moiety by Dicer endonuclease, and rapid translocation of siRNA to endoplasmic reticulum for recruitment into functional RISC (RNA interference silencing complex). We confirmed the target gene silencing both in vitro and in vivo, and proved that it occurs through RNA interference mechanism. Our current results indicate that downstream effectors of TLR9 pathway may be involved in RISC assembly and/or activation. Overall, the CpG-siRNA strategy provides a novel opportunity for overcoming cancer immunoresistance with translational potential for therapy of various malignancies.
<i>Hansenula polymorpha</i> as a novel yeast system for the expression of heterologous genes (1988)

The advantages of Hansenula polymorpha as a new yeast expression system are discussed in terms of the powerful and regulatable methanol oxidase promoter and the organism's ability to grow on cheap carbon sources. The development of techniques for conventional genetic analysis is described. A total of 218 mutants have been assigned to 62 complementation groups, three genes have been found to be linked forming the first linkage group in this organism. Methods for molecular transformation have been developed allowing the expression of heterologous genes. The disruptive integration and expression of the neomycin phosphotransferase is described.
cDNA Cloning of the Human Polybromo-1 Gene on Chromosome 3p21 (2002)

The bromodomain is suggested as a chromatin-targeting domain involved in regulation of gene expression and chromatin structure. We here report the cDNA cloning of the human polybromo-1 (hPB1) gene that encodes a 1634-amino acid polypeptide containing six bromodomains. The hPB1 polypeptide shows 91% identity to the previously identified chicken polybromo-1 with conservation of the bromodomains and other characteristic features. Northern blot analysis detected the ubiquitous expression of hPB1 mRNA in a variety of human tissues. Four alternative splicings were found within the hPB1 coding region: three making in-frame deletions and one resulting in a C-terminal truncation. The hPB1 gene is located on chromosome 3p21, where the tumor suppressor genes for breast, lung and kidney cancers have been mapped.
Heavy Metal Removal from Aqueous Solutions Using Fly-Ash Derived Zeolite NaP1 (2022)

Abstract Fly-ash derived zeolites have recently -received great attention as cheaper adsorbents to remove heavy metals from water since they can be synthesized from a waste product. In this study, we evaluated the single- and multi-cation adsorption efficiencies of fly-ash derived NaP1 for the removal of zinc (Zn), copper (Cu) and lead (Pb). We also determined precipitation and leaching from NaP1 during the adsorption. Results showed that the uptake capacities for Zn (34 mg/g) and Pb (192 mg/g) were higher than other fly-ash derived NaP1 and adsorbents such as clinoptilolite and activated carbon. The Cu uptake was estimated ~ 14.6 mg/g. Pb 2+ &gt; Cu 2+ &gt; Zn 2+ is the order for the metal cation selectivity of NaP1. Langmuir adsorption isotherm and pseudo-second order kinetic model fitted best for all elements. The metal uptake occurred in 15 min. Diffusion of hydrated metals through microporous channels is the rate-determining step.
Novel coupled microstrip wideband filters with spurious response suppression (2007)

Wideband coupled line filters with spurious response suppression (2/0) in the millimeter wave range are reported. The first filter exhibits a relative bandwidth of 62% with a return loss better than 20 dB and a suppression of the second spurious passband of more than 40 dB. The very high necessary couplings to achieve that large bandwidth in combination with the spurious suppression are realized by removing partially the ground metallization beneath the proposed coupling sections. The filters are directly compatible to microstrip circuits without the need for complicated transitions. They do not require techniques like substrate suspension or dielectric overlay to match the even- and odd-mode phase velocities, but are realizable on a classical substrate with ground. Further, simulation and measurement results of a second, high selective filter (11th order) with an even higher bandwidth of 78% are shown. Measurement and simulation results are fitting very well.
Fast single-element PN acquisition for the TDRSS MA system (1988)

The authors present a description and performance analysis of a new PN code acquisition approach for the tracking and data relay satellite system with multiple access (TDRSS MA) return subsystem. The MA subsystem uses a phased array on-board the TDRS with 30 elements whose received signals are each independently retransmitted to the ground for beam forming. In the current operational system, acquisition is performed by using a serial search of the possible PN epochs on the beam-formed 30-element signal. In contrast, the new approach performs acquisition on a single (arbitrary) element signal using a parallel (i.e., simultaneous) search of all possible PN epochs. Since only one element signal is used, no beam forming is required prior to PN acquisition. The approach is based on sampling and digital processing of the received signal. The new method also incorporates techniques which counteract the effects of Doppler and asynchronous data modulation. The probability of correct acquisition as a function of acquisition time, signal-to-noise ratio, data rate, and user satellite Doppler is analyzed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Figure 2 from Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy (2023)

Supplementary Figure 2 from Heparin-Binding EGF-Like Growth Factor Is a Promising Target for Ovarian Cancer Therapy
&lt;title&gt;Comprehensive multiplatform collaboration&lt;/title&gt; (2003)

We describe the architecture and implementation of our comprehensive multi-platform collaboration framework known as Columbia InterNet Extensible Multimedia Architecture (CINEMA). It provides a distributed architecture for collaboration using synchronous communications like multimedia conferencing, instant messaging, shared web-browsing, and asynchronous communications like discussion forums, shared files, voice and video mails. It allows seamless integration with various communication means like telephones, IP phones, web and electronic mail. In addition, it provides value-added services such as call handling based on location information and presence status. The paper discusses the media services needed for collaborative environment, the components provided by CINEMA and the interaction among those components.
Efficient single-pass optical parametric generator for environmental gas sensing based on periodically poled stoichiometric lithium tantalate (2007)

An efficient 1064 nm-pumped OPG that could be operated at room temperature using a PPMgSLT crystal is presented. 1.6 W total output for a 4.8 W input, power conversion of 50% was achieved.
MANDAS: management of distributed applications and systems (1995)

Many challenging issues and problems exist in the management of distributed applications and systems in distributed computing environments. The broad goals of the MANDAS (Management of Distributed Applications and Systems) project are to identify and solve problems arising in the development of a management framework and architecture, in the design, modeling and management of distributed applications, and in the definition of a set of services required to support new tools and techniques. The MANDAS research team involves researchers from multiple universities in both Canada and the United States. This paper provides an overview of the research issues being addressed in the research project and gives some insight into results to date.
The demonstration of two types of suppressor mechanism in leprosy patients and their contacts by quadruple skin-testing with mycobacterial reagent mixtures (1983)

A previous study in Nepal involving skin-testing simultaneously with four different mycobacterial reagents (three of them mixtures) re vealed that the addition, in the same skin-test site, of pooled reagents from fast-g rowing mycobacteria locally suppressed the response to pooled slow growers. This finding has been confirmed in Bombay . It has also been shown that the addition of reagents prepared from certain fast-growing species to that prepared from slow-growers in one skin-test site will suppress the re sponse to the same slow-grower reagent injected alone in the other arm. This type of suppression probably requires recognition of species-specific antigens of the fast-growing species concerned. The importance of the observations in relation to leprosy and possible mechanisms underlying them are discussed.
Longterm complications of hand assisted and standard laparoscopic surgery for diseases of the colon and rectum (2007)

Pandey, S. MD; Sonoda, T. MD; Trencheva, K. BSN; Lee, S. MD; Milsom, J. W. MD Author Information