gebhart/patrepeval huggingface dataset:
Nickel(II) complexes of cyclic tetradentate thioethers (1969)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNickel(II) complexes of cyclic tetradentate thioethersWilliam Rosen and Daryle H. BuschCite this: J. Am. Chem. Soc. 1969, 91, 17, 4694–4697Publication Date (Print):August 1, 1969Publication History Published online1 May 2002Published inissue 1 August 1969https://pubs.acs.org/doi/10.1021/ja01045a017https://doi.org/10.1021/ja01045a017research-articleACS PublicationsRequest reuse permissionsArticle Views628Altmetric-Citations138LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Nb2O5 nanowire photoanode sensitized by a composition-tuned CdSxSe1−x shell (2012)

Nb2O5 nanowires (NWs) were grown by the thermal oxidation of Nb foils. The thermal chemical vapor transport of CdS/CdSe powders produces Nb2O5–CdSxSe1−x core–shell NWs with complete composition tuning. In the alloy composition, CdSe-like and CdS-like phases exist in the outer and inner regions of the shell, respectively, forming unique multi-shell structures. As x increases, the thickness of the CdSe-like outer shell decreases, while that of the CdS-like inner shell increases. We fabricated photoelectrochemical (PEC) cells using the as-grown Nb2O5–CdSxSe1−x NWs and measured their photocurrents and hydrogen generation rates under AM 1.5G irradiation. The PEC cells showed excellent photoconversion efficiency, which is comparable to that of TiO2–CdSxSe1−x NWs. It indicates that the present Nb2O5 NW promises an excellent photoanode of solar cell devices. The multi-shell structures increase the PEC performance by producing novel band alignment for efficient electron–hole separation following enhanced visible-range photon absorption.
Inhibition of phosphatidylinositol-specific phospholipase C: Studies on synthetic substrates, inhibitors and a synthetic enzyme (1996)

Enzyme inhibition studies on phosphatidylinositol-specific phospholipase C (PI-PLC) from B. Cereus were performed in order to gain an understanding of the mechanism of the PI-PLC family of enzymes and to aid inhibitor design. Inhibition studies on two synthetic cyclic phosphonate analogues (1,2) of inositol cyclic-1:2-monophosphate (cIP), glycerol-2-phosphate and vanadate were performed using natural phosphatidylinositol (PI) substrate in Triton X100 co-micelles and an NMR assay. Further inhibition studies on PI-PLC from B. Cereus were performed using a chromogenic, synthetic PI analogue (DPG-PI), an HPLC assay and Aerosol-OT (AOT), phytic acid and vanadate as inhibitors. For purposes of comparison, a model PI-PLC enzyme system was developed employing a synthetic Cu(II)-metallomicelle and a further synthetic PI analogue (IPP-PI). The studies employing natural PI substrate in Triton X100 co-micelles and synthetic DPG-PI in the absence of surfactant indicate three classes of PI-PLC inhibitors: (1) active-site directed inhibitors (e.g. 1,2); (2) water-soluble polyanions (e.g. tetravanadate, phytic acid); (3) surfactant anions (e.g. AOT). Three modes of molecular recognition are indicated to be important: (1) active site molecular recognition; (2) recognition at an anion-recognition site which may be the active site, and; (3) interfacial (or hydrophobic) recognition which may be exploited to increase affinity for the anion-recognition site in anionic surfactants such as AOT. The most potent inhibition of PI-PLC was observed by tetravanadate and AOT. The metallomicelle model system was observed to mimic PI-PLC in reproducing transesterification of the PI analogue substrate to yield cIP as product and in showing inhibition by phytic acid and AOT.
High-power one-, two-, and three-dimensional photonic crystal edge-emitting laser diodes for ultra-high brightness applications (2008)

Direct laser diodes can typically provide only a limited single mode power, while ultrahigh-brightness is required for many of the market-relevant applications. Thus, multistage power conversion schemes are applied, when the laser diodes are used just as a pumping source. In this paper we review the recent advances in ultra-large output aperture edge-emitting lasers based on the photonic band crystal (PBC) concept. The concept allows near- and far-field engineering robust to temperature and strain gradients and growth nonuniformities. High-order modes are selectively filtered and the effective optical confinement of the fundamental mode can be dramatically enhanced. At first, we show that robust ultra-narrow vertical beam divergence (<5 deg. FWHM) can be achieved simultaneously with ultrahigh differential efficiency (80-85%) and significant single mode power for several wavelengths of the key regions. A maximum single mode power of 1.4 W is achieved for 980 nm lasers. At second we extend the PBC concept towards the 2D photonic crystal. A significant field extension in the vertical direction allows a robust fabrication of the field-coupled lateral multistripe PBC arrays with a total multistripe width of 0.2 mm. We also demonstrate that the concept of high-order modes filtering works well also in the lateral direction. Finally, we address possible options for 3D managing of light towards wavelength stabilized laser operation by processing of the multistripe arrays along their lengths. The concept opens a way for 3D photonic crystal edge emitting lasers potentially allowing scalable single mode power increase to arbitrary high levels.
Finite Pressure Effects in Magnetically Shielded Hall Thrusters (2014)

We describe the effects of finite pressure in a large vacuum facility on a magnetically shielded Hall thruster using internally and externally mounted cathodes. A numerical model of the pumping system was first used to guide the placement of an ionization gauge and an auxiliary propellant injector used for increasing the backpressure. The laboratory model H6MS Hall thruster was operated at 300 and 800 V discharge voltage, 2-20 A discharge current, and 0.6-9.0 kW discharge power at pressures calibrated for xenon from 2.4 to 100 uTorr-Xe. The hollow cathode was located in three positions: internally mounted on thruster centerline and two external mounts outside of the magnetic circuit. Performance variations exceed that expected from ingestion of background gas in all configurations but were still consistent with prior studies of unshielded Hall thrusters. Magnetic field strength, cathode location, and magnitude of discharge oscillations can greatly affect the apparent level of ingestion, which suggests that mechanisms other than ingestion of background gas affect the pressure sensitivity of the discharge. In particular, cathode location is shown to have a profound influence on the measured performance and stability. When the internally mounted cathode is used, the plasma response is shown to be much less sensitive to pressure changes than when an externally mounted cathode is employed. Our results suggest that high-power Hall thrusters using internally mounted cathodes minimize the effects of finite pressure on performance and stability, providing a path for reliably correlating ground tests with flight performance.
Characterization of the Ultra Wideband Body Area Propagation Channel (2006)

Using wireless sensors placed on a person to continuously monitor health information is a promising new application. In developing these sensors, detailed knowledge of the communication channel is essential. However, there are currently very few measurements describing propagation around the body. To address this problem, we have measured electromagnetic waves traveling near the torso to derive a simple pathless law. The pathless law is then extended to include the influence of arm movements and a surrounding office environment. This paper describes our measurement campaign and the basic characteristics of the body area radio channel.
ChemInform Abstract: DIFFERENCES IN REACTIVITY AND SELECTIVITY BETWEEN RADICAL ADDITIONS AND CYCLOADDITIONS (1980)

Abstract Olefine (II) und Acetylene (IV) werden hinsichtlich ihrer Reaktivität mit Cyclohexyl‐Radikalen (I) bzw. mit Diazomethan (VII) untersucht.
Structure-adaptive anisotropic filter applied to fingerprints (2005)

We propose a modified structure-adaptive anisotropic filter, which uses local intensity orientation and an anisotropic measure to control the shape of the filter kernel, and apply it to fingerprints. The modification is made in the frequency domain by converting the common structure-adaptive anisotropic filter from a low-pass filter to a band-pass one. We show that the modified structure-adaptive anisotropic filter can be effectively applied to applications, such as fingerprint image enhancement, in which the oriented patterns in local neighborhood form a sinusoidal-shaped plane wave with a well-defined frequency and orientation. The performance of the proposed structure-adaptive anisotropic filter is compared to some other filters used for minutiae detection. The proposed filter shows some improvement in terms of computational time and efficiency.
Modular Pluggable Analyses for Data Structure Consistency (2004)

LARA
A Quantitative Study on the Effects of Environment and Microstructure on Pit Initiation in Al-alloys (2009)

Potentiostatic testing was employed to examine pit initiation on AA7075-T651 exposed to chloride solutions. The influence of chloride concentration, potential, and temperature on pit initiation was studied. An automated method for counting current transients is presented, and the applicability of potentiostatic testing in Al alloys is generally discussed.
CONDUCTING POLYMER BLEND THIN-FILMS FROM GRANULAR METAL POLYMER COMPOSITES (1991)

An original method of growing a new class of thin films of composite conducting materials is described. A technological approach which allows the deposition of a fluorinated polymer-polypyrrole alloy on a solid substrate is outlined. This procedure employs a cosputtered granular metal in which the metal grains are chlorinated to produce an oxidizing agent capable of promoting pyrrole polymerization. Morphological, optical and electrical characterization of the material are reported. The low-temperature behaviour of the resistance was investigated. The polymer blend seems to be less disordered than polypyrrole thin films grown on an oxidizing salt pattern from the vapour phase.
Decision letter: Neural basis for regulation of vasopressin secretion by anticipated disturbances in osmolality (2021)

Two non-overlapping neural circuits that involve the lamina terminalis and arcuate nucleus of hypothalamus independently drive feedforward anticipatory suppression and activation of vasopressin neurons by drinking and feeding, respectively.
Dual Alamouti Codes (2011)

Alamouti codes have been widely recognized for their full-diversity performance, while they provide a symbol rate of one with symbol-by-symbol decoding complexity. To decode an Alamouti code, the receiver requires the channel state information (CSI), while the transmitter operates blindly without CSI. This paper investigates the dual scenario when CSI is available only at the transmitter and not at the receiver. Such an assumption is valid for time-division duplex (TDD) systems where the transmitter obtains the CSI from the reciprocal channel and the receiver does not want to estimate the channel because of complexity. We propose dual Alamouti codes that do not require CSI at the receiver and exploit transmit CSI to achieve the performance of full-diversity with rate-one and symbol-by-symbol decoding complexity. Moreover, the dual codes provide the same bit error rate (BER) performance as the original Alamouti codes for equal-energy constellations. The dual Alamouti codes have potential applications in TDD systems to save the cost of training and simplify receiver design.
Dynamic analysis of the three-level LLC resonant converter for a rectifier in HVDC distribution system (2015)

The comparison of the power stage dynamics between a conventional LLC converter and a three-level LLC converter is presented in this paper. The frequency response was similar in continuous current mode, but different in discontinuous current mode. Moreover, how the variation of circuit parameters affects the transfer function of the three-level LLC converter is studied. The experimental verification is provided as well.
Personalized antiplatelet therapy: state of the art (2012)

Overwhelming evidence exists that thrombus generation resulting from platelet activation and aggregation is the primary process involved in the occurrence of the myocardial infarction and stent thrombosis. Despite the proven clinical efficacy of dual antiplatelet therapy, wide antiplatelet response variability associated with clopidogrel therapy was demonstrated in pharmacodynamic studies where approximately one in three patients exhibited high on-treatment platelet reactivity (HPR). Generally, physicians do not objectively assess the intensity of the adenosine diphosphate-P2Y12 interaction in their high-risk patients treated with clopidogrel. Instead most clinicians use a non-selective or one-size-fits-all approach. HPR and CYP2C19 LoF carriage are associated with clinical outcomes in high-risk clopidogrel-treated patients who have undergone percutaneous coronary intervention (PCI). Although we do not yet have conclusive evidence from a large-scale randomized trial that personalized antiplatelet therapy improves patient outcomes, a class IIb recommendation has been given in the guidelines to perform genotyping or phenotyping in high-risk PCI patients if a change in antiplatelet therapy will ensue based on the test results. It may be reasonable at this time to assess platelet function and perform genotyping in clopidogrel-treated high-risk patients and treat with more potent P2Y12 receptor therapy selectively.
New doxorubicin nanoparticles engineered from calcium-crosslinked carbomer and a microemulsion precursor (2016)

The purpose of this study was to investigate a new polymeric system and production process in which self-assembled doxorubicin-loaded nanoparticles were synthetized by using a water-in-oil microemulsion as a template and calcium ions as cross-linkers. The manufacturing process combined cross-linking of carbomer within a W/O microemulsion followed by a phase-separation technique to avoid using organic solvents for extraction. To assess the sustained release behavior of doxorubicin from the nanoparticles, we have developed a new simple method based on the permeability coefficient of a synthetic membrane mounted on Franz diffusion cell system. Franz cells were preferred over the commonly used dialysis tubing because they provide adequate measures of the diffusion area as well as the volumes of the media in both sides of the membrane. The lower permeability values obtained for nanoparticles have shown that the release is a limiting step of the diffusion process, while the calculated straight lines may imply that the apparent release rate of the nanoparticle ensembles is close to a zero-order kinetics. The new drug release method for the evaluation of nano-carriers, utilizing a simple linear model to determine the permeability coefficient, has been proposed for perfect sink and non-sink conditions.
Silicon Oxynitrophosphide <scp>Nanoscale Coating</scp> Enhances Antioxidant Marker‐Induced Angiogenesis During in vivo Cranial Bone‐Defect Healing (2020)

Critical-sized bone defects are challenging to heal because of the sudden and large volume of lost bone. Fixative plates are often used to stabilize defects, yet oxidative stress and delayed angiogenesis are contributing factors to poor biocompatibility and delayed bone healing. This study tests the angiogenic and antioxidant properties of amorphous silicon oxynitrophosphide (SiONPx) nanoscale-coating material on endothelial cells to regenerate vascular tissue in vitro and in bone defects. in vitro studies evaluate the effect of silicon oxynitride (SiONx) and two different SiONPx compositions on human endothelial cells exposed to ROS (eg, hydrogen peroxide) that simulates oxidative stress conditions. in vivo studies using adult male Sprague Dawley rats (approximately 450 g) were performed to compare a bare plate, a SiONPx-coated implant plate, and a sham control group using a rat standard-sized calvarial defect. Results from this study showed that plates coated with SiONPx significantly reduced cell death, and enhanced vascular tubule formation and matrix deposition by upregulating angiogenic and antioxidant expression (eg, vascular endothelial growth factor A, angiopoetin-1, superoxide dismutase 1, nuclear factor erythroid 2-related factor 2, and catalase 1). Moreover, endothelial cell markers (CD31) showed a significant tubular structure in the SiONPx coating group compared with an empty and uncoated plate group. This reveals that atomic doping of phosphate into the nanoscale coating of SiONx produced markedly elevated levels of antioxidant and angiogenic markers that enhance vascular tissue regeneration. This study found that SiONPx or SiONx nanoscale-coated materials enhance antioxidant expression, angiogenic marker expression, and reduce ROS levels needed for accelerating vascular tissue regeneration. These results further suggest that SiONPx nanoscale coating could be a promising candidate for titanium plate for rapid and enhanced cranial bone-defect healing. © 2020 The Authors. <i>JBMR Plus</i> published by Wiley Periodicals LLC. on behalf of American Society for Bone and Mineral Research.
Regulation of KCNQ4 Potassium Channel Prepulse Dependence and Current Amplitude by SGK1 in &lt;i&gt;Xenopus&lt;/i&gt; oocytes (2005)

The KCNQ gene family comprises voltage-gated potassium channels expressed in epithelial tissues (KCNQ1, KCNQ5), inner ear structures (KCNQ1, KCNQ4) and the brain (KCNQ2-5). KCNQ4 is expressed in inner and outer hair cells of the inner ear where it determines electrical excitability. Accordingly, loss of function mutations of the KCNQ4 gene cause hearing loss. Several K+ channels including the closely related KCNQ1/KCNE1 channel are regulated by the serum- and glucocorticoid-inducible kinase (SGK) family. The present study utilized the Xenopus oocyte system to explore effects of SGK isoforms on KCNQ4 mediated K(+)-currents: KCNQ4 channels activated in a voltage dependent manner with half maximal activation at -10 mV. The peak channel activity was significantly increased by prepulsing. Coexpression of wild type SGK1 but not coexpression of the inactive mutant (K127N)SGK1 significantly increased current amplitudes (by 67 %) and significantly increased the resting potential of KCNQ4 expressing oocytes. Here we describe for the first time a prepulse dependence of KCNQ4 channels with increased currents after hyperpolarizing prepulses. Coexpression of SGK1 significantly attenuated the effect of prepulsing on peak currents. Mutation of Ser to Asp or Ala in the putative phosphorylation consensus sequence in KCNQ4 significantly decreased the sensitivity to SGK1-coexpression. In conclusion, SGK1 regulates current amplitudes and kinetic properties of KCNQ4 channel activity, an effect sensitive to mutations in the SGK1 consensus sequence of the channel.
ChemInform Abstract: Chiral Amidophosphane—Rhodium(I)‐Catalyzed Asymmetric Conjugate Arylation of Acyclic Enones with Arylboronic Acids. (2010)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis of (.+‐.)‐Epicubenol. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Antibody-Mediated Targeting of Alpha PDGF Receptor to Inhibit the Progression of Skeletal Micro-Metastases (2012)

Abstract : In this second year of funding we have shown that: a) We have established the time frame during which PDGFR support the survival and progression of PCa cells disseminated to the skeleton. The results deriving from our pre-clinical animal model of metastasis indicate that this receptor is of paramount importance during the initial phases of bone colonization. This information presents high value for the stratification of patients to be included in phase-III clinical trials for the antibody IMC- 3G3 (Olaratumab). Thus monoclonal, fully human antibody is directed to target PDGFR and being currently evaluated in phase-II trials for a variety of solid tumors, including PCa. b) We have identified a new 3-gene expression signature correlated with the ability of PCa cells to colonize the skeleton in animals. The implications for human pathology need to be fully evaluated; however, the evidence accumulated in our pre-clinical model is compelling. Interestingly, all the encoded protein products are soluble and secreted proteins. This seems to indicate that PCa cells with metastatic abilities modify the bone microenvironment in a paracrine fashion and that surrounding stromal cells may reciprocate by producing survival and growth factors. If this model is confirmed, our results may help identifying novel molecular targets for anti-metastatic therapies.
Advances in Computational Mathematics, Special Issue on Localization, Diversity and Uncertainty in Signal Representations (2014)

International audience
Converse theorems in Lyapunov’s second method and applications for fractional order systems (2019)

We establish a characterization of the Lyapunov and Mittag-Leffler stability through (fractional) Lyapunov functions, by proving converse theorems for Caputo fractional order systems. A hierarchy for the Mittag-Leffler order convergence is also proved which shows, in particular, that fractional differential equation with derivation order lesser than one cannot be exponentially stable. The converse results are then applied to show that if an integer order system is (exponentially) stable, then its corresponding fractional system, obtained from changing its differentiation order, is (Mittag-Leffler) stable. Hence, available integer order control techniques can be disposed to control nonlinear fractional systems. Finally, we provide examples showing how our results improve recent advances published in the specialized literature.