gebhart/patrepeval huggingface dataset:
The Response of Muscle Protein Anabolism to Combined Hyperaminoacidemia and Glucose-Induced Hyperinsulinemia Is Impaired in the Elderly<sup>1</sup> (2000)

Muscle mass declines with aging. Amino acids alone stimulate muscle protein synthesis in the elderly. However, mixed nutritional supplementation failed to improve muscle mass. We hypothesized that the failure of nutritional supplements is due to altered responsiveness of muscle protein anabolism to increased amino acid availability associated with endogenous hyperinsulinemia. We measured muscle protein synthesis and breakdown, and amino acid transport in healthy young (30 +/- 3 yr) and elderly (72 +/- 1 yr) volunteers in the basal postabsorptive state and during the administration of an amino acid-glucose mixture, using L-[ring-(2)H(5)]phenylalanine infusion, femoral artery and vein catheterization, and muscle biopsies. Basal muscle amino acid turnover was similar in young and elderly subjects. The mixture increased phenylalanine leg delivery and transport into the muscle in both groups. Phenylalanine net balance increased in both groups (young, -27 +/- 8 to 64 +/- 17; elderly, -16 +/- 4 to 29 +/- 7 nmol/(min.100 mL); P: < 0.0001, basal vs. mixture), but the increase was significantly blunted in the elderly (P: = 0.030 vs. young). Muscle protein synthesis increased in the young, but remained unchanged in the elderly [young, 61 +/- 17 to 133 +/- 30 (P: = 0. 005); elderly, 62 +/- 9 to 70 +/- 14 nmol/(min.100 mL) (P: = NS)]. In both groups, protein breakdown decreased (P: = 0.012) and leg glucose uptake increased (P: = 0.0258) with the mixture. We conclude that the response of muscle protein anabolism to hyperaminoacidemia with endogenous hyperinsulinemia is impaired in healthy elderly due to the unresponsiveness of protein synthesis.
B Vitamins and Magnetic Resonance Imaging–Detected Ischemic Brain Lesions in Patients With Recent Transient Ischemic Attack or Stroke (2012)

http://vitatops.highway1.com.au/. Unique identifier: NCT00097669 and ISRCTN74743444.
Moving Beyond the Experiment to See Chemists Like Me: Cultural Relevance in the Organic Chemistry Laboratory (2021)

Culturally relevant pedagogy and critical race feminism can be utilized to challenge the inequality and masculine nature of chemistry. Such an approach is needed to increase the representation of Black women in STEM and can be leveraged to create a curriculum that addresses the lived experiences of these individuals. This approach can shift the dynamics of the learning environment by allowing students to take the lead in creating knowledge and, in the case of students, seeing how other Black women experience and contribute to the field of chemistry in meaningful ways. In acknowledging the intersection of gender, race, and personal interest in connection with culturally relevant pedagogies, learning strategies have been created to engage Black women. Student interview and survey data revealed their interest and growing knowledge of the relevance of science. The information also showed that completing the culturally relevant lab activities helped students see themselves as developing scientists. Based on the response to the activities, it is believed that the intentional design of an academically challenging and inclusive curriculum will enhance students’ perception of themselves as scientists.
Direct aperture deformation: An interfraction image guidance strategy (2006)

A new scheme, called direct aperture deformation (DAD), for online correction of interfraction geometric uncertainties under volumetric imaging guidance is presented. Using deformable image registration, the three-dimensional geometric transformation matrix can be derived that associates the planning image set and the images acquired on the day of treatment. Rather than replanning or moving the patient, we use the deformation matrix to morph the treatment apertures as a potential online correction method. A proof-of-principle study using an intensity-modulated radiation therapy plan for a prostate cancer patient was conducted. The method, procedure, and algorithm of DAD are described. The dose-volume histograms from the original plan, reoptimized plan, and rigid-body translation plan are compared with the ones from the DAD plan. The study showed the feasibility of the DAD as a general method for both target dislocation and deformation. As compared with using couch translation to move the patient, DAD is capable of correcting both target dislocation and deformations. As compared with reoptimization, online correction using the DAD scheme could be completed within a few minutes rather than tens of minutes and the speed gain would be at a very small cost of plan quality.
Report on the Second SIGIR Workshop on Neural Information Retrieval (Neu-IR'17) (2018)

The second SIGIR workshop on neural information retrieval (Neu-IR?17) took place on August 11, 2017, in Tokyo, Japan. Following the successful 2016 edition, the workshop continued to serve as a forum for academic and industrial researchers to present new work on neural methods for retrieval. In addition, a special track was organized focusing on resources for evaluation and reproducibility, including proposals for public benchmarking datasets and shared model repositories. A total of 19 papers?which included five special track papers? were presented in the form of oral or poster presentations. Organizers of four of the TREC 2017 tracks were invited to present at the workshop on how these IR tasks may be suitable for evaluating recent data-hungry neural approaches. The full-day workshop?with more than 170 registrants?concluded with an engaging panel discussion.
Abstract 572: Tumor-activated PD1-directed IL-2 increased antigen specific T cells in tumors and demonstrated anti-tumor activity in mice (2023)

Abstract Although PD-1/PD-L1 therapies have shown significant activity across a range of tumor types, only a subset of patients (10-30%) achieve durable responses. With the goal of improving response and application to PD-1/PD-L1 therapies, we have leveraged our proprietary Xilio Advanced Cytokine Therapies (X-ACT) platform to develop PD1/IL2-ACT, a PD-1 blocker enhanced with a tumor-activated, engineered IL-2 agonist. The activity of IL-2 is blocked by a protein domain that prevents IL-2Rβγ binding until activated in the tumor microenvironment by matrix metalloproteinases . Tumor selective activation of IL-2 enables dosing of PD1/IL2-ACT at sufficient exposure levels to block immunosuppressive PD1/PD-L1 signaling as well as mitigating systemic IL-2 driven toxicity. PD1/IL2-ACT is designed to enable in cis engagement of IL-2 receptors on antigen experienced PD-1+ CD8+ T cells in the tumor microenvironment (TME), inducing effector T cell functions while preventing regulatory T cell (Treg) mediated immune suppression. In a preclinical model, PD1/IL2-ACT, compared to anti-PD1 alone, induced significant tumor growth inhibition. Further, PD1/IL2-ACT was better tolerated than a PD-1 directed unmasked IL-2Rβγ biased agonist in the same preclinical model. Pharmacodynamic studies showed that PD1/IL2-ACT did not significantly change immune cell profiles in the periphery but increased antigen specific CD8+ T cells in the TME, consistent with preferential engagement of PD1+ effector T cells at the tumor site. Ex vivo protease cleavage assays performed in human tumors demonstrated significant activation of PD1/IL2-ACT by tumors of multiple indications but minimal activation in human plasma. A pharmacokinetic study in nonhuman primates revealed PD1/IL2-ACT can achieve comparable exposure levels to existing PD-1 blocking immunotherapies. Taken together, these data illustrate that PD1/IL2-ACT has the potential to broaden the activity of existing immunotherapies by inhibiting the PD1/PDL1 axis as well as directing an immunostimulatory cytokine to antigen specific T cells in the TME. Citation Format: Ertan Eryilmaz, Wilson Guzman, Dheeraj S. Tomar, Parker Johnson, Stephanie Hsiao, Lisa Quinn, Nancy Chan, Jimit Lakhani, Brendan Whalen, Rosa Quiroz, Kurt Jenkins, Oleg Yerov, Will Scott, Justin Greene, Zhen Liu, Megan McLaughlin, Sallyann Vu, Chelsea Turcotte, Hanumantha R. Madala, Jacob Taylor, Caitlin O'Toole, Magali Pederzoli-Ribeil, Haley Duprey, Natalia Malkova, Damiano Fantini, David Crowe, Sean Yang, Kyle Smith, Joseph Card, Janice Lee, Kerri Smith, Benjamin Nicholson, Jijun Dong, Jennifer O'Neil, Carl U. Bialucha. Tumor-activated PD1-directed IL-2 increased antigen specific T cells in tumors and demonstrated anti-tumor activity in mice [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 572.
ChemInform Abstract: Synthesis and Coordination Chemistry (with Platinum(II) and Molybdenum(0)) of New Bis(bis(trifluoromethyl)phosphano)alkanes. Structure of a New Bis(phosphano)methanide Complex. (1989)

Abstract Diphosphines, in part for the first time, are prepared in yields between 55 and 67% by an improved procedure heating (CF 3 ) 2 P‐P(CF3)2 and the corresponding diiodoalkane at 130 °C. These highly π‐acidic ligands react with PtCl 2 (PhCN) 2 or cis‐Mo(CO)4(piperidine)2 in CHCl 3 at 70 or 80 °C, respectively, to give the complexes (I) or (II).
HLA‐DRB1 and DQB1 genotypes in patients with insulin‐dependent neonatal diabetes mellitus. A study of 13 cases (2000)

Insulin-dependent neonatal diabetes mellitus (NDM) is a rare form of diabetes with a heterogeneous genetic background. The HLA-DRB1 and DQB1 genotypes were determined for 13 patients with NDM, from 9 unrelated families. Four patients had permanent NDM (PNDM) and 9 patients had transient NDM (TNDM). No excess of HLA susceptibility markers for type 1 diabetes (IDDM) was observed in this series of patients, whatever the forms of diabetes PNDM or TNDM. Paternal isodisomy of chromosome 6 was observed in two TNDM cases. These observations are consistent with the current hypothesis that there is a recessive susceptibility gene, at least in the transient form of the disease, unlinked to the MHC locus on chromosome 6. Although established in a short series, our results do not support an additive role of IDDM1 in the progression of the disease.
Valproic acid induces NET cell growth arrest and enhances tumor suppression of the receptor-targeted peptide–drug conjugate via activating somatostatin receptor type II (2015)

The combination of VPA and a SSTR2-targeting agent provides us a promising approach in treatment of carcinoid tumors.
Input-Adaptive Proxy for Black Carbon as a Virtual Sensor (2019)

Missing data has been a challenge in air quality measurement. In this study, we develop an input-adaptive proxy, which selects input variables of other air quality variables based on their correlation coefficients with the output variable. The proxy uses ordinary least squares regression model with robust optimization and limits the input variables to a maximum of three to avoid overfitting. The adaptive proxy learns from the data set and generates the best model evaluated by adjusted coefficient of determination (adjR<sup>2</sup>). In case of missing data in the input variables, the proposed adaptive proxy then uses the second-best model until all the missing data gaps are filled up. We estimated black carbon (BC) concentration by using the input-adaptive proxy in two sites in Helsinki, which respectively represent street canyon and urban background scenario, as a case study. Accumulation mode, traffic counts, nitrogen dioxide and lung deposited surface area are found as input variables in models with the top rank. In contrast to traditional proxy, which gives 20-80% of data, the input-adaptive proxy manages to give full continuous BC estimation. The newly developed adaptive proxy also gives generally accurate BC (street canyon: adjR<sup>2</sup> = 0.86-0.94; urban background: adjR<sup>2</sup> = 0.74-0.91) depending on different seasons and day of the week. Due to its flexibility and reliability, the adaptive proxy can be further extend to estimate other air quality parameters. It can also act as an air quality virtual sensor in support with on-site measurements in the future.
Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes (2022)

Taken together, our results corroborate the role of OCT-1 in the transport of metformin and also point at OCT1 genetic variations possibly affecting the transport of metformin into the cells and hence its subsequent action in responders and non-responders.
Induction of tumour hypoxia by a vasoactive agent A combined NMR and radiobiological study (1989)

The effect of hydralazine treatment on 3 murine tumours (RIF-1, KHT and 16/C) was monitored using 31P-NMR. Changes in the 31P-NMR spectrum are compared with measurements of radiobiological hypoxic fraction (RHF) in the RIF-1 and KHT. Hydralazine is known to reduce temporarily blood flow in experimental tumours, and thus cause a transient increase in the RHF to 100% (in RIF-1 and KHT). This correlates with a decline in energy status as measured by 31P-NMR (i.e. there was an increase in Pi in all three tumours). Time-course data from the RIF-1 and KHT tumours show that maintenance of anaesthesia prolongs the hypoxia induced by hydralazine.
Distinct regions of frequent loss of heterozygosity of chromosome 5p and 5q in human esophageal cancer (1998)

Loss of heterozygosity (LOH) studies reported thus far suggest that tumor suppressor loci on chromosome 5q are important in esophageal cancer (EC) while little is known about the involvement of chromosome 5p. To investigate the potential existence of tumor suppressor gene(s) on chromosome 5 contributing to the development of EC, we performed LOH studies using a total of 24 polymorphic markers spanning the entire chromosome 5. Seventy primary esophageal cancers were microdissected and allelic deletions were detected by polymerase chain reaction (PCR)-single strand conformation polymorphism or by microsatellite analysis. LOH was observed in at least 1 of the loci in 47 of 70 (67%) esophageal tumors. Initially, 40 tumors [24 squamous cell carcinomas (SCC) and 16 adenocarcinomas (ADC)], each with matched histologically normal esophageal mucosa, were analyzed at 15 marker loci on 5p and 5q. A novel locus, D5S667 on 5p15.2, exhibited the highest frequency of LOH (44%) in these tumors along with another previously reported region of frequent deletion, irf-1 (5q31.1). In a series of 30 additional EC tumors (11 SCC and 19 ADC), a detailed LOH analysis of chromosome 5p15.2 region was conducted using 10 additional polymorphic markers, which mapped the frequently deleted region within 1 cM. Overall, LOH at the D5S667 locus was observed more frequently in SCC than in ADC (62% vs. 23%, p = 0.01). This significant rate of LOH of a distinct region of chromosome 5p implicates the existence of a putative tumor suppressor gene locus involved in EC. Int. J. Cancer 78:600–605, 1998. © 1998 Wiley-Liss, Inc.
Numerical Simulation on Light Output of UV-based White Light-Emitting Diodes with Multicolor Phosphor Blends (2008)

We developed a new simulation method for designing the luminescence profiles of phophor-based white light-emitting diodes (LEDs). By combining the rate equations for absorption/emission processes by phosphors with a differential equation for spatial distribution of light intensity, we take into account the cascade process of phosphor emission due to the reabsorption of photons. We found that our model is suitable for a systematic design method of white light sources with multicolor phosphor blends.
Evaluation perceptive longitudinale de la dysarthrie dans des maladies lysosomales avant et après traitement (2009)

International audience
H1259 Container Foams: Performance Data on Aged Materials (2002)

Samples of the three cushioning foams used in the H1259 weapon storage container were obtained in 1997, 1998, 2000 and 2001 and tested for density, compression set and compressive strength using the same procedures specified for acceptance testing. Foams from six containers, all about 30 years old and located at Pantex, were evaluated. The bottom cushioning foam is a General Plastics polyurethane foam and the two side pads are rebonded polyurethane foams. All the tests were carried out at room temperature. When compared to the original acceptance requirements the foams were generally in-spec for density and compressive strength at 10% strain and were generally out-of-spec for compression set and compressive strength at 50% strain. Significant variability was noted in the performance of each foam sample and even more in the container-to-container foam performance. The container-to-container variability remains the major unknown in predicting the long-term suitability of these containers for continued use. The performance of the critical bottom cushion foams was generally more uniform and closer to the specified performance than that of the rebonded foams. It was judged that all the foams were adequate for continued use as storage container foams (not shipping) under controlled conditions to mitigate temperature extremes or high impact. This archived information is important in evaluations of the continued suitability for weapon storage use of the H1259 containers and other containers using the same foam cushions.
Pseudo Lateration: Millimeter-Wave Localization Using a Single RF Chain (2017)

While radio-based indoor localization schemes achieve decimeter-scale accuracy, they typically require precise reference measurements, multiple infrastructure nodes, or a multi-RF-chain anchor. In this paper, we propose Pseudo LATeration (PLAT), an indoor localization protocol that requires only a single RF chain infrastructure anchor and does not require prior knowledge of the environment. PLAT leverages the directionality and propagation characteristics of millimeter-wave transmissions to relax the requirement of multiple infrastructure anchors and RF chains by constructing pseudo anchors from reflected signal paths. By combining these pseudo anchors with time-of-flight measurements for distance estimation, PLAT can localize a user's device in indoors. Our evaluation reveals centimeter scale location accuracy for typical office environments. In testbed measurements and simulations, localization errors are centimeter scale for distances up to 1.5 m and beamwidths at or below 8.6 degrees. Although accuracy decreases to decimeter scale with additional propagation distance, we show that multiple reflection paths can mitigate this effect.
Topical Fluorides: Effects on Physiologic and Biochemical Processes (1987)

The ingestion of fluoride from dentifrices or mouthrinses can contribute substantially to the total daily intake of the ion, even in communities that provide optimally fluoridated drinking water. It is concluded that the frequent and unsupervised use of these products by children six years of age or younger, especially those living in areas with water fluoridation, places them at risk of dental fluorosis. Recommendations to reduce the risk are presented. The use of 1.23% (12,300 ppm) APF gels, particularly in the absence of suctioning during the application and expectoration after the application, is associated with the swallowing of relatively large quantities of fluoride. The resulting increases in plasma fluoride levels may be sufficient to cause dental fluorosis, as judged by studies with laboratory animals, and a reduction in the kidney's ability to concentrate the urine, as judged by studies with both laboratory animals and humans. The epigastric distress experienced by some patients during or after APF gel applications appears to be due, at least in part, to a direct toxic effect of fluoride on the gastric mucosa. Data from studies with humans and laboratory animals indicate that there may also be associated changes in plasma and tissue cAMP levels, glucose metabolism, and salivary amylase secretion. There is an immediate need for the dissemination to the dental profession of standardized methods for gel application that will minimize the quantities of fluoride available for ingestion and systemic absorption.
&lt;title&gt;Defect geometries and laser-induced damage in multilayer coatings&lt;/title&gt; (1994)

A correlation between laser-induced damage and the height of a coating defect was found from an examination of HfO<SUB>2</SUB>/SiO<SUB>2</SUB> mirrors made by three different coating vendors. The nodular defects in these reactive e-beam deposited mirrors were studied using the combination of scanning electron microscopy (SEM), optical microscopy, focused ion beam (FIB) and atomic force microscopy (AFM) techniques. Each vendor has small defects in common, but characteristically different large defects. also the majority of seeds that caused the defects were made of hafnia, not silica. The apparent mechanical stability of the defects within the coating plays a major role in the laser resistance (1064 nm and 10 ns) of a high damage threshold coating.
Crypto-Verifying Protocol Implementations in ML (2007)

We intend to narrow the gap between concrete implementations and verified models of cryptographic protocols. We consider protocols implemented in F#, a variant of ML, and verified using CryptoVerif, Blanchet's protocol verifier for computational cryptography. We experiment with compilers from F# code to CryptoVerif processes, and from CryptoVerif declarations to F# code. We present two case studies: an implementation of the Otway-Rees protocol, and an implementation of a simplified password-based authentication protocol. In both cases, we obtain concrete security guarantees for a computational model closely related to executable code.
Intra-pocket antibiotic therapy using resorbable and non-resorbable slow-release devices containing tetracycline. (2000)

Since it is a disease mainly caused by plaque--an aggregate of various bacteria--periodontal disease can be considered a local infection. Thus, it has seemed reasonable to utilize antibiotics to suppress the intrapocket bacteria, specifically or nonspecifically. When antibiotics are administered orally, however, massive doses over a prolonged period of time are needed to attain a therapeutic effect. This increases the risk of adverse reactions as well as developing resistant strains of bacteria. To overcome these problems, local drug delivery systems (LDDS) were devised to combat the local infection. However, the intrapocket antibiotic delivery systems have yet to be fully evaluated for clinical effectiveness; to prove the therapeutic effectiveness of locally administered antibiotics, the drug must reach the base of the periodontal pocket and the effective concentration of the antibiotic against the pathogenic bacteria must be maintained for a long time. This concise review presents with figures, tables, and a comprehensive list of references the many studies which have used the various tetracyclines as LDDS to treat periodontal disease.