gebhart/patrepeval huggingface dataset:
Cloning of wheat keto-acyl thiolase 2B reveals a role of jasmonic acid in grain weight determination (2020)

Grain weight (GW) is one of the component traits of wheat yield. Existing reports have shown that multiple phytohormones are involved in the regulation of GW in different crops. However, the potential role of jasmonic acid (JA) remains unclear. Here, we report that triticale grain weight 1 (tgw1) mutant, with marked reductions in both GW and JA content, is caused by a premature stop mutation in keto-acyl thiolase 2B (KAT-2B) involved in β-oxidation during JA synthesis. KAT-2B overexpression increases GW in wild type and boosts yield. Additionally, KAT-2B compliments the grain defect in tgw1 and rescues the lethal phenotype of the Arabidopsis kat2 mutant in a sucrose-free medium. Despite the suppression of JA synthesis in tgw1 mutant, ABA synthesis is upregulated, which is accompanied by enhanced expression of SAG3 and reduction of chlorophyll content in leaves. Together, these results demonstrate a role of the JA synthetic gene KAT-2B in controlling GW and its potential application value for wheat improvement.
The Autonomic Margins of Safety of Metocurine and d-Tubocurarine in the Cat (1979)

The potencies of metocurine and d-tubocurarine for neuromuscular and autonomic blockade and histamine release were determined in cats anesthetized with chloralose and pentobarbital. The autonomic margins of safety of these drugs were determined by measuring the ratios of ED50 for sympathetic block to ED95 for neuromuscular block; ED50 for vagal block to ED95 for neuromuscular block; ED50 for histamine release to ED95 for neuromuscular block. Metocurine is 14 times more potent than d-tubocurarine as a neuromuscular blocking agent in the cat, but its autonomic blocking action is three times weaker than the of d-tubocurarine and its histamine-releasing action is less than half that of d-tubocurarine. The combination of higher neuromuscular blocking potency and weaker autonomic effect gives metocurine a much higher autonomic margin of safety than d-tubocurarine in the cat.
Modulation of Glutathione Hemostasis by Inhibition of 12/15‐Lipoxygenase Prevents ROS‐Mediated Cell Death after Hepatic Ischemia and Reperfusion (2017)

Our data show that inhibition of 12/15-lipoxygenase causes significant cell death reduction after hepatic ischemia and reperfusion by enhancing glutathione metabolism. We conclude that GPX4-dependent cell death signaling cascade might play a major role in development of hepatic IRI, in which the investigated proteins JNK, caspase-3, ERK1/2, and PARP might contribute to tissue damage.
A system for spoken query information retrieval on mobile devices (2002)

With the proliferation of handheld devices, information access on mobile devices is a topic of growing relevance. This paper presents a system that allows the user to search for information on mobile devices using spoken natural-language queries. We explore several issues related to the creation of this system, which combines state-of-the-art speech-recognition and information-retrieval technologies. This is the first work that we are aware of which evaluates spoken query based information retrieval on a commonly available and well researched text database, the Chinese news corpus used in the National Institute of Standards and Technology (NIST)s TREC-5 and TREC-6 benchmarks. To compare spoken-query retrieval performance for different relevant scenarios and recognition accuracies, the benchmark queries-read verbatim by 20 speakers-were recorded simultaneously through three channels: headset microphone, PDA microphone, and cellular phone. Our results show that for mobile devices with high-quality microphones, spoken-query retrieval based on existing technologies yields retrieval precisions that come close to that for perfect text input (mean average precision 0.459 and 0.489, respectively, on TREC-6).
Araise awareness to extreme flood events in a context of lack of risk culture. The development of ORRION and CREDO-CRUE tools in the Rhine Graben (France -Germany -Switzerland), 2019 (2019)

International audience
Tooth wear, dentine hypersensitivity and time since dietary acid in-vivo (2014)

Objective: The aim of this study was to investigate the relationship between tooth wear and dentine hypersensitivity on occlusal/incisal tooth surfaces and the time since dietary acid consumption. Method: 350 subjects were recruited from hospital and general practice in the south east of England aged 19-34 years old. The severity of tooth wear and dentine hypersensitivity were calculated on occlusal/incisal tooth surfaces per subject using Basic Erosive Wear Examination (BEWE) and Cumulative Hypersensitivity Index (CHI) scores respectively at each appointment. The CHI score relied on evaporative stimuli applied to each occlusal/incisal tooth surface. The subjects were also asked about the time since their last acidic food or drink consumption. Result: Tooth wear was recorded in 93% (n=327) of subjects and dentine hypersensitivity was recorded in 56% (n=196) of subjects. A positive statistically signi!cant relationship existed between the severity of tooth wear and severity of dentine hypersensitivity recorded using BEWE and CHI on occlusal/incisal tooth surfaces (p&lt;0.01).The severity of dentine hypersensitivity and tooth wear on occlusal/incisal tooth surfaces were associated with the time since the subject’s last acidic food consumption (p&lt;0.01). Among those subjects who consumed an acidic beverage within 60 minutes of their appointment, 87.2% (n=130) had dentine hypersensitivity. Among subjects who had consumed the acidic beverage more than one hour previously, the prevalence of dentine hypersensitivity was 12.8% (n=19). Conclusion: This study showed that occlusal/incisal surfaces are a predominant site for tooth wear and dentine hypersensitivity. The severity of tooth wear on occlusal/incisal tooth surfaces is associated with the dentine hypersensitivity severity. If subjects consume dietary acidic beverages they are more likely to have dentine hypersensitivity.
The virtual museum of sculpture (2008)

This paper presents the Virtual Museum of Sculpture (VMS) of Pietrasanta, a permanent Virtual Reality installation enabling users to interactively explore a museographical diffused virtual space. The virtual environment hosts several digital 3D models of sculptures realized by important Italian artists of the XX century, connected for historical and cultural reasons with the town of Pietrasanta, a renowned place near the marble quarries of Alpi Apuane. The VMS is currently being enriched of new content, aimed at promoting local art and culture, with the perspective of developing guidelines for an integrated methodology sharing museological and ICT know-hows, targeted to the design of specific virtual applications and to the qualitative evaluation of their social impact as a novel important means of communication and learning.
Affective Instability Prior to and after Thoughts about Self-Injury in Individuals With and At-Risk of Psychosis: A Mobile Phone Based Study (2013)

It has been proposed that affective instability may be associated with thoughts about self-injury. The aim of this study was to test the hypotheses that instability in feelings of depression, but not anxiety, guilt, or hostility, would predict greater concurrent and subsequent thoughts about self-injury. Thirty-six individuals with psychosis completed questions on touch-screen mobile phones at semi-random times each day for one week. The instability of depression predicted greater concurrent and subsequent levels of thoughts about self-injury, even when controlling for depression level. Conversely, self-injurious thoughts predicted more stable depression. The instability of guilt, anxiety, and hostility did not significantly predict levels of thoughts about self-injury. Results indicate that a variable depressive state may trigger the onset of thoughts about self-injury, which increases the risk of its subsequent recurrence. The onset of self-injurious thoughts may, however, have a stabilizing effect on subsequent depression.
Nonconventional Yeasts Engineered Using the CRISPR-Cas System as Emerging Microbial Cell Factories (2022)

Because the petroleum-based chemical synthesis of industrial products causes serious environmental and societal issues, biotechnological production using microorganisms is an alternative approach to achieve a more sustainable economy. In particular, the yeast Saccharomyces cerevisiae is widely used as a microbial cell factory to produce biofuels and valuable biomaterials. However, product profiles are often restricted due to the Crabtree-positive nature of S. cerevisiae, and ethanol production from lignocellulose is possibly enhanced by developing alternative stress-resistant microbial platforms. With desirable metabolic pathways and regulation in addition to strong resistance to diverse stress factors, nonconventional yeasts (NCY) may be considered an alternative microbial platform for industrial uses. Irrespective of their high industrial value, the lack of genetic information and useful gene editing tools makes it challenging to develop metabolic engineering-guided scaled-up applications using yeasts. The recently developed clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein (Cas) system is a powerful gene editing tool for NCYs. This review describes the current status of and recent advances in promising NCYs in terms of industrial and biotechnological applications, highlighting CRISPR-Cas9 system-based metabolic engineering strategies. This will serve as a basis for the development of novel yeast applications.
Head and neck carcinoma in the United States (2012)

LORHAN documented differences in patient characteristics and treatments between community and academic settings for a large series of patients in the United States.
Validation of the freezing of gait questionnaire in patients with Parkinson's disease (2009)

To revalidate the Freezing of Gait Questionnaire (FOG-Q), patients with Parkinson's disease (PD) were randomly assigned to receive rasagiline (1 mg/day) (n = 150), entacapone (200 mg with each dose of levodopa) (n = 150), or placebo (n = 154). Patients were assessed at baseline and after 10 weeks using the FOG-Q, Unified Parkinson's Disease Rating Scale (UPDRS), Beck Depression Inventory (BDI), and Parkinson's Disease Questionnaire (PDQ-39). FOG-Q dimensionality, test-retest reliability, and internal reliability were examined. Convergent and divergent validities were assessed by correlating FOG-Q with UPDRS, BDI, and PDQ-39. Comparisons between FOG-Q item 3 and UPDRS item 14 were also made. Principal component analysis indicated that FOG-Q measures a single dimension. Test-retest reliability and internal reliability of FOG-Q score was high. FOG-Q was best correlated to items of the UPDRS relating to walking, general motor issues, and mobility. Correlations between baseline and endpoint suggested that FOG-Q item 3 is at least as reliable as UPDRS item 14. At baseline, 85.9% of patients were identified as "Freezers" using FOG-Q item 3 (> or =1) and 44.1% using UPDRS item 14 (> or =1) (P < 0.001). FOG-Q was a reliable tool for the assessment of treatment intervention. FOG-Q item 3 was effective as a screening question for the presence of FOG.
&lt;title&gt;Classifying hyperspectral remote sensing imagery with independent component analysis&lt;/title&gt; (2005)

In this paper, we investigate the application of independent component analysis (ICA) to remotely sensed hyperspectral image classification. We focus on the performance of Joint Approximate Diagonalization of Eigenmatrices (JADE) algorithm, although the proposed method is applicable to other popular ICA algorithms. The major advantage of using ICA is its capability of classifying objects with unknown spectral signatures in an unknown image scene, i.e., unsupervised classification. However, ICA suffers from computational expensiveness, which limits its application to high dimensional data analysis. In order to make it applicable to hyperspectral image classification, a data preprocessing procedure is employed to reduce the data dimensionality. Noise adjusted principal component analysis (NAPCA) is used for this purpose, which can reorganize the original data information in terms of signal-to-noise ratio, a more appropriate criterion than variance when dealing with images. The preliminary results demonstrate that the selected major components from NAPCA can better represent the object information in the original data than those from ordinary principal component analysis (PCA). As a result, better classification using ICA is expected.
Application of a Preisach-type hysteresis model to the magnetic evaluation of material degradation (2005)

Preisach-based magnetic characterization is applied as a non-destructive method to evaluate material degradation due to metal fatigue. At predetermined interruptions of the cyclic mechanical loading a set of first order symmetric and a set of second order minor magnetisation loops are measured and analysed using both the classical and the moving Preisach model. The evolution of microstructure dependent magnetic features such as the Preisach distribution function, the mean-field parameter k and the local coercive field distribution Qc(hc) is monitored: k increases and the peak value of Qc decreases with the number of stress cycles. Moreover, for both parameters the rate of change is higher during the last 10% of the fatigue lifetime.
Exploiting the biomolecular corona: pre-coating of nanoparticles enables controlled cellular interactions (2018)

Formation of the biomolecular corona ultimately determines the successful application of nanoparticles in vivo. Adsorption of biomolecules such as proteins is an inevitable process that takes place instantaneously upon contact with physiological fluid (e.g. blood). Therefore, strategies are needed to control this process in order to improve the properties of the nanoparticles and to allow targeted drug delivery. Here, we show that the design of the protein corona by a pre-formed protein corona with tailored properties enables targeted cellular interactions. Nanoparticles were pre-coated with immunoglobulin depleted plasma to create and design a protein corona that reduces cellular uptake by immune cells. It was proven that a pre-formed protein corona remains stable even after nanoparticles were re-introduced to plasma. This opens up the great potential to exploit protein corona formation, which will significantly influence the development of novel nanomaterials.
Eclipse: An End-to-End Platform for Low-Cost, Hyperlocal Environmental Sensing in Cities (2022)

This paper presents Eclipse, a platform for low-cost urban environmental sensing using solar-powered and cellular-connected devices. Dense sensor networks promise to monitor pollution at fine spatial and temporal resolutions, yet few cities have actually implemented such networks due to high costs and limited accuracy. We address these barriers by developing an end-to-end framework for urban air quality sensing with minimal infrastructure requirements. We designed an unobtrusive device that collects data on fine particulate matter (PM <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2.5</inf> ), temperature, relative humidity, and barometric pres-sure. A modular design further includes four low-cost gas sensors - Ozone (03), Nitrogen Dioxide (NO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ), Sulfur Dioxide (SO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ), and Carbon Monoxide (CO) - selected based on local priorities. We deployed 115 devices across Chicago, reliably collecting data for over 90% of expected sensor-hours from July 2 - September 30, 2021. We further developed a calibration strategy that reduced errors by 41.2 – 98.8%, improving accuracy to levels recommended for hotspot detection (PM <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2.5</inf> and 03) or education (NO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> and SO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> ). Through this work, we offer insights on the real-world deployment of a replicable, large-scale, end-to-end platform for hyperlocal urban environmental sensing.
Low Cost Metabolic Fuel Sensor for On-Demand Personal Health and Fitness Tracking (2020)

Abstract Metabolic health in the general population has declined significantly in just one to two generations despite increased emphasis on dieting and exercise. A challenge in prescribing a healthy diet and exercise regimen is the variability individuals exhibit in response to particular foods, calorie restricted diets and exercise regimens. This paper describes a prototype metabolic fuel sensor designed for ease of use and personal tracking of metabolic energy expenditure and fuel substrate utilization. Examples of the sensor measurements and potential applications to weight management and tracking of chronically high blood glucose are described.
Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination (2011)

Progressive telomere shortening from cell division (replicative aging) provides a barrier for human tumor progression. This program is not conserved in laboratory mice, which have longer telomeres and constitutive telomerase. Wild species that do/do not use replicative aging have been reported, but the evolution of different phenotypes and a conceptual framework for understanding their uses of telomeres is lacking. We examined telomeres/telomerase in cultured cells from > 60 mammalian species to place different uses of telomeres in a broad mammalian context. Phylogeny-based statistical analysis reconstructed ancestral states. Our analysis suggested that the ancestral mammalian phenotype included short telomeres (< 20 kb, as we now see in humans) and repressed telomerase. We argue that the repressed telomerase was a response to a higher mutation load brought on by the evolution of homeothermy. With telomerase repressed, we then see the evolution of replicative aging. Telomere length inversely correlated with lifespan, while telomerase expression co-evolved with body size. Multiple independent times smaller, shorter-lived species changed to having longer telomeres and expressing telomerase. Trade-offs involving reducing the energetic/cellular costs of specific oxidative protection mechanisms (needed to protect < 20 kb telomeres in the absence of telomerase) could explain this abandonment of replicative aging. These observations provide a conceptual framework for understanding different uses of telomeres in mammals, support a role for human-like telomeres in allowing longer lifespans to evolve, demonstrate the need to include telomere length in the analysis of comparative studies of oxidative protection in the biology of aging, and identify which mammals can be used as appropriate model organisms for the study of the role of telomeres in human cancer and aging.
Crystal quality of SiGe films fabricated by the condensation technique and characterized by medium energy ion scattering (2019)

Abstract Highly strained SiGe-on-insulator (SGOI) channels are desired for p-type transistor performance enhancement. A fine characterization of the crystal quality as a function of depth of such films would be of great interest as the SiGe crystal quality influences its electrical properties. The crystal quality of SGOI films fabricated by the condensation technique is measured by the Medium Energy Ion Scattering technique using the channeling effect. Indeed, the presence of structural defects such as dislocations is associated with atoms displaced from their normal lattice sites that contribute as a consequence to the scattering yield in channeling conditions. This paper compares the crystal quality of low Ge content and high Ge content SGOI films fabricated by condensation. It is shown that the SiGe crystal is degraded in the top part of the film, both before and after condensation, and that the presence of Ge, even at low fraction, at the interface with the buried oxide, induces crystal damage in the immediate vicinity of the interface. We finally highlight that, except close to the interfaces with oxide films, SGOI films fabricated by condensation feature high crystal qualities up to 57% Ge concentration and 2% compressive strain.
Junction between the great cerebral vein and the straight sinus: An anatomical, immunohistochemical, and ultrastructural study on 25 human brain cadaveric dissections (2008)

The cerebral venous system is poorly understood, and best appreciated under macroscopic anatomical considerations. We present an anatomical and immunohistochemical studies to better define the morphological characteristics of the junction between the great cerebral vein and the straight sinus. Twenty-five cadaveric specimens from the anatomy laboratory of the University Victor Segalen of Bordeaux were studied. The observation of the venous junctions with the straight sinus was performed under an operating microscope. The smooth muscular actin immunohistochemical staining was performed for 18 veno-sinosal junctions. Five venous junctions were observed using an electron microscope. We observed 3 different anatomic aspects: type 1 was a junction with a small elevation in its floor and a posterior thickening (14 cases); type 2 was a junction with an outgrowth on the floor like a cornice (7 cases); and type 3 was a junction presenting a nodule. Microscopic study of type 1 and 2 junctions showed a positive coloration to orceine attesting the presence of elastic fibers. Immunohistochemistry revealed the presence of smooth muscular actin and S 100 protein attesting the presence of smooth muscular fibers and nervous fibers. We observed in the ultrastructural study, a morphological progression of the endothelium. The venous orifice of the great cerebral vein into the straight sinus could be anatomically assimilated as a true "sphincter." Its function in the regulation of the cerebral blood flow needs further exploration.
Ein Sensor für cAMP. Modulation der intrazellulären cAMP Konzentration durch Serotonin-Rezeptoren (2002)

The HvCNG channel from the moth Heliothis virescens is highly sensitive to cAMP concentrations ranging between 0.1 M and 5 M.This HvCNG channel was over-expressed in Spodoptera frugiperda (Sf.9) cells to measure endogenous cAMP levels.Hyperpolarization-activated inward currents were measured in the whole-cell patch-clamp configuration with pipettes filled with different cAMP concentrations to calibrate the system.Varying the cAMP concentration between 0 M and 100 M in the pipette, the half-maximal activation voltage (V 1/2 ) was shifted by +28.51.7 mV.The activation time constant ( a ) was used as a parameter for cAMP quantification because it was independent of the expression level of HvCNG channels. a changed from 110660 ms at 0 M cAMP to 2657 ms at a saturating concentration of 1 mM cAMP.A dose-response relationship yielded values of 0.6 M for the half-maximal cAMP concentration and 1.5 for the Hill coefficient.Activation of endogenous adenylyl cyclases by 50 M forskolin induced an elevation of the cAMP level by about 1.60.2M.Co-expressions of HvCNG channels in combination with the mouse 5-HT 4(a) -or 5-HT 1A -receptors and the corresponding G s -or G i -proteins were successful and allowed us to also verify receptor-induced changes of the cAMP level.Stimulation of m5-HT 4(a) -receptors by 0.1 M 5-HT induced an increase of cAMP of about 4.61.5 M, whereas cAMP levels decreased from a control value of 10.2 M to 0.410.1 M after stimulation of the m5-HT 1A -receptors.