1601 ONCOFETAL PROTEIN IMP3 A POTENTIAL BIOMARKER FOR INVASIVE BLADDER CANCER (2012)

You have accessJournal of UrologyBladder Cancer: Invasive II1 Apr 20121601 ONCOFETAL PROTEIN IMP3 A POTENTIAL BIOMARKER FOR INVASIVE BLADDER CANCER Eugene K. Cha, Bjoern Volkmer, Francesca Khani, Michael Rink, David A. Green, Yao-Tseng Chen, Juan-Miguel Mosquera, Mark A. Rubin, Douglas S. Scherr, Richard Hautmann, Rainer Kuefer, Shahrokh F. Shariat, and Brian D. Robinson Eugene K. ChaEugene K. Cha New York, NY More articles by this author , Bjoern VolkmerBjoern Volkmer Kassel, Germany More articles by this author , Francesca KhaniFrancesca Khani New York, NY More articles by this author , Michael RinkMichael Rink New York, NY More articles by this author , David A. GreenDavid A. Green New York, NY More articles by this author , Yao-Tseng ChenYao-Tseng Chen New York, NY More articles by this author , Juan-Miguel MosqueraJuan-Miguel Mosquera New York, NY More articles by this author , Mark A. RubinMark A. Rubin New York, NY More articles by this author , Douglas S. ScherrDouglas S. Scherr New York, NY More articles by this author , Richard HautmannRichard Hautmann Ulm, Germany More articles by this author , Rainer KueferRainer Kuefer Ulm, Germany More articles by this author , Shahrokh F. ShariatShahrokh F. Shariat New York, NY More articles by this author , and Brian D. RobinsonBrian D. Robinson New York, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1374AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Members of the insulin-like growth factor II mRNA binding protein (IMP) family play an important role in RNA trafficking and stabilization, cell growth, and cell migration. IMP3 is an oncofetal protein that is expressed at low or undetectable levels in normal adult tissue. One previous study demonstrated that IMP3 expression was associated with poor prognosis in patients with non-muscle-invasive bladder cancer. We hypothesized that IMP3 expression could be a prognostic factor in patients undergoing radical cystectomy (RC) for urothelial carcinoma of the bladder (UCB). METHODS We utilized a monoclonal antibody to perform immunohistochemistical analyses on tissue microarrays containing samples from 381 consecutive UCB patients treated with RC between 1988 and 2003 at one academic center. IMP3 expression (absent vs. expressed) was evaluated by two pathologists who were blinded to clinical outcome. RESULTS IMP3 was expressed in the normal urothelium in 1/15 patients and in 151/383 (39.4%) of malignant tissues from RC specimens. The rate of IMP3 expression increased with advancing pathological stage (p=0.02). Median follow-up was 129 months (IQR 111). Expression of IMP3 was associated with an increased risk of disease recurrence (p<0.001) and cancer-specific mortality (p=0.01). In a multivariable analysis that adjusted for the effects of pathologic stage and lymph node metastasis, IMP3 expression was independently associated with disease recurrence (HR 1.67, p=0.01), but not cancer-specific mortality. CONCLUSIONS IMP3 is expressed in ∼40% of high-risk UCB specimens at RC. IMP3 expression is associated with advanced pathologic tumor stage and disease recurrence in UCB patients treated with RC. Further studies are needed to more fully evaluate the clinical value of IMP3 as a prognostic biomarker and potential target for therapy in UCB. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e648 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Eugene K. Cha New York, NY More articles by this author Bjoern Volkmer Kassel, Germany More articles by this author Francesca Khani New York, NY More articles by this author Michael Rink New York, NY More articles by this author David A. Green New York, NY More articles by this author Yao-Tseng Chen New York, NY More articles by this author Juan-Miguel Mosquera New York, NY More articles by this author Mark A. Rubin New York, NY More articles by this author Douglas S. Scherr New York, NY More articles by this author Richard Hautmann Ulm, Germany More articles by this author Rainer Kuefer Ulm, Germany More articles by this author Shahrokh F. Shariat New York, NY More articles by this author Brian D. Robinson New York, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...