gebhart/patrepeval huggingface dataset:
Abstract 54: Incidence And Predictors Of Dural Arteriovenous Fistulae After Cerebral Venous Sinus Thrombosis: Analysis Of ACTION-CVT (2023)

Background: Intracranial dural arteriovenous fistulae (DAVF) are uncommon vascular anomalies with a reported incidence of 0.2 per 100,000 person years. An association between cerebral venous thrombosis (CVT) and DAVF has been reported; however, the direction of causality between the two remains uncertain. We aimed to identify the incidence and predictors of development of DAVF among patients with CVT. Methods: This is a post-hoc analysis of Anticoagulation in the Treatment of Cerebral Venous Thrombosis (ACTION-CVT), a multicenter retrospective study comparing outcomes of CVT patients treated with warfarin versus direct oral anticoagulants (DOACs) from 2015 to 2020. Patients were included in this analysis if they did not have DAVF on initial imaging and had follow-up vascular imaging during the study. Clinical, imaging, and anticoagulation characteristics of patients who developed DAVF were compared to those who did not. Stepwise binary logistic regression including important variables (achieving p&lt;0.1 on univariate analyses) was used to determine predictors of DAVF development. Results: A total of 751 patients (median age 43, 66% female) met inclusion criteria of whom 13 (1.7%) developed DAVF with an estimated rate of 2.40 per 100 patient years. Patients with DAVF were less likely to have headache at presentation (53.8% vs 79.3%, p=0.037), but more likely to have no venous recanalization on follow-up imaging (46.2% vs 14.8%, p=0.008), baseline cortical vein thrombosis (15.4% vs 2.7%, p=0.053), and received warfarin (vs. DOACs) as initial oral anticoagulant (84.6% vs 58.7%, p=0.085) but the latter two missed the statistical significance threshold. In stepwise binary logistic regression analysis, cortical vein thrombosis (OR 7.98, 95% CI 1.40-45.35, p=0.02) and lack of venous recanalization (OR 4.93, 95% CI 1.48-16.39, p=0.01) were associated with development of DAVF. Conclusion: In this large multicenter study of CVT, the incidence of DAVF development was higher than the previously reported rate in the general population. The presence of cortical vein thrombosis and lack of venous recanalization were associated with increased risk of development of DAVF.
Blocking of β-Adrenergic Receptors During the Subfertile Period Inhibits Spontaneous Ovarian Cyst Formation in Rats (2012)

As aging proceeds, fertility problems arise, and the success rate of in vitro fertilization declines. During reproductive aging, rat ovaries present spontaneous formation of cysts, followed by a concomitant increase in sympathetic nerve activity, causing infertility and cessation of ovarian function. β2-Adrenergic receptors, which are activated by noradrenaline (NA), modify follicular development and steroid secretions; thus, increased nerve activity has been associated with the development and maintenance of cystic structures. The purpose of this work was to block the effect of this sympathetic activity through in vivo administration of propranolol (a β-adrenergic receptor antagonist) to determine whether it delays cyst formation and cessation of the ovarian function in rats that had reached the subfertile period. Propranolol was administrated daily to 8- and 10-month-old rats for 2 months. Estrous cycling activity was monitored by vaginal smear, serum concentration of the steroidal hormones was determined by enzyme-immune assay and morphological analysis of the ovaries was performed using 6 μm tissue slices stained with hematoxylin-eosin. Propranolol increased the number of healthy follicles, the ovulation rate, and levels of serum sexual steroids (androstenedione, testosterone, and estradiol) and recovered estrous cycling activity. It also decreased the number of follicular cysts. These results suggest that the blockade of β-adrenergic receptors recovered ovarian function during reproductive aging. It is suggested that propranolol induces a time-dependent extension of the subfertile window, and it could be used to increase the success rate of fertility programs in aging woman.
Sulforaphane Modifies Histone H3, Unpacks Chromatin, and Primes Defense (2017)

Modern crop production calls for agrochemicals that prime plants for enhanced defense. Reliable test systems for spotting priming-inducing chemistry, however, are rare. We developed an assay for the high-throughput search for compounds that prime microbial pattern-induced secretion of antimicrobial furanocoumarins (phytoalexins) in cultured parsley cells. The screen produced 1-isothiocyanato-4-methylsulfinylbutane (sulforaphane; SFN), a secondary metabolite in many crucifers, as a novel defense priming compound. While elucidating SFN's mode of action in defense priming, we found that in Arabidopsis (<i>Arabidopsis</i><i>thaliana</i>) the isothiocyanate provokes covalent modification (K4me3, K9ac) of histone H3 in the promoter and promoter-proximal region of defense genes <i>WRKY6</i> and <i>PDF1</i><i>2</i>, but not <i>PR1</i> SFN-triggered H3K4me3 and H3K9ac coincide with chromatin unpacking in the <i>WRKY6</i> and <i>PDF1</i><i>2</i> regulatory regions, primed <i>WRKY6</i> expression, unprimed <i>PDF1</i><i>2</i> activation, and reduced susceptibility to downy mildew disease (<i>Hyaloperonospora arabidopsidis</i>). Because SFN also directly inhibits <i>H</i><i>arabidopsidis</i> and other plant pathogens, the isothiocyanate is promising for the development of a plant protectant with a dual mode of action.
<i>In vitro</i>and<i>in vivo</i>skin anti-aging evaluation of gel containing niosomes loaded with a semi-purified fraction containing gallic acid from<i>Terminalia chebula</i>galls (2011)

The semi-purified fraction loaded in niosomes indicated not only higher chemical stability of gallic acid containing in the fraction, but also more in vivo anti-aging activities than the unloaded fraction when incorporated in gel.
Tocolysis in the management of preterm prelabor rupture of membranes at 22–33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM) (2021)

ClinicalTrials.gov identifier: NCT03976063 (registration date June 5, 2019).
A simple practical method for determination of moisture transfer coefficient of mature concrete using a combined experimental-numerical approach (2016)

In this paper, a simple practical method is introduced in which a simple weight measurement of concrete and finite element numerical analysis are used to determine the moisture transfer coefficient of concrete with a satisfactory accuracy. Six concrete mixtures with different water-to-cementitious material (w/cm) ratios and two pozzolanic materials including silica fume and zeolite were examined to validate the proposed method. The comparison between the distribution of the moisture content obtained from the model and the one from the experimental data during both the wetting and drying process properly validated the performance of the method.With the proposed method, it was also shown that the concrete moisture transfer coefficient considerably depends on the pore water saturation degree. The use of pozzolanic materials and also lowering w/cm ratio increased the moisture transfer coefficient during the initial sorption, and then, it significantly decreased with an increase in the water saturation degree.
T cells from <i>Leishmania major</i> -susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation (2009)

Barbi, J., F. Brombacher, and A. R. Satoskar. 2008. T cells from Leishmania major -susceptible BALB/c mice have a defect in efficiently up-regulating CXCR3 upon activation. [ J. Immunol . 181: 4613–4620][1] . In Results , Fig. 7 B was mislabeled and a sentence explaining the data in Fig. 7 C was
Exploitation of the coffee-ring effect to realize mechanically enhanced inkjet-printed microelectromechanical relays with U-bar-shaped cantilevers (2014)

We report a mechanically enhanced inkjet-printed microelectromechanical (MEM) relay with a U-bar-shaped cantilever by exploiting the coffee-ring effect. The printed cantilever shape, especially the effective thickness caused by the elevated walls, can be controlled during the drying process by outward convective flow of silver nanoparticles. This enhances mechanical stiffness to efficiently produce a strongly suspended cantilever that is immune to collapse- and curling-related failures. This approach to enhancing cantilever stiffness is unique to printing-based processes using metal-nanoparticle inks and is not feasible for conventional photolithography processes. The resulting printed MEM relays show a pull-in voltage of only 6.6 V and an on/off ratio of 108 with extremely low on-state resistance (∼14.3 Ω) and off-state leakage that is comparable to those of conventional silicon-based MEM relays.
Erratum: Speckle-modulating optical coherence tomography in living mice and humans (2017)

Nature Communications 8: Article number: 15845 (2017); Published: 20 June 2017; Updated: 11 July 2017 An incorrect version of the Supplementary Information was inadvertently published with this Article which included incorrect figure references in Supplementary Table 4. The Article has now been updated to include the correct version of the Supplementary Information.
Interaction between gene variants of the serotonin transporter promoter region (5‐HTTLPR) and catechol <i>O</i>‐methyltransferase (COMT) in borderline personality disorder (2008)

Borderline personality disorder (BPD) is characterized by a heterogeneous symptomatology with instability in impulse control, interpersonal relationships and self-image. BPD patients display repeated self-injury, chronic suicidal tendencies and emotional dysregulation, mainly dysregulation of negative affect. In its etiology, genetic and environmental factors have been suggested. Recently, an investigation in male healthy volunteers found gene-gene effects of the catechol-O-methyl-transferase (COMT) low-activity (Met(158)) and the low-expression allele of the deletion/insertion (short/long or S/L, respectively) polymorphism in the serotonin transporter-linked promoter region (5-HTTLPR) on the central processing of aversive stimuli. The purpose of the present study was to test for association between BPD and the COMT Val(158)Met single nucleotide polymorphism (SNP), the 5-HTTLPR S/L variant and the interaction of these two gene variants. One hundred sixty one well-defined Caucasian BPD patients and 156 healthy controls were recruited from central Germany. In BPD patients, the genotype COMT Met(158)Met was over-represented compared to healthy controls (P = 0.0085; adjusted P = 0.034). We observed no differences in 5-HTTLPR genotypes between BPD and controls (P = 0.286). Additionally, the COMT Met(158)Met genotype was significantly over-represented in BPD patients carrying at least one 5-HTTLPR S allele (P = 0.0007; adjusted P = 0.028). Logistic regression analysis confirmed an interaction of the COMT Met(158) and the 5-HTTLPR S allele (P = 0.001). These data suggest an involvement of altered dopaminergic and/or noradrenergic neurotransmission as well as an interactive effect of COMT and 5-HTTLPR gene variants in the etiology of BPD, and underline the usefulness of analyses of gene-gene effects in diseases of complex inheritance with multiple genes involved.
Parathyroid hormone 1-34 and skeletal anabolic action (2017)

L. Osagie-Clouard, A. Sanghani, M. Coathup, T. Briggs, M. Bostrom, G. Blunn. Parathyroid hormone 1-34 and skeletal anabolic action: The use of parathyroid hormone in bone formation. Bone Joint Res 2017;6:14-21. DOI: 10.1302/2046-3758.61.BJR-2016-0085.R1.
E-VPN Ping Mechanism for Virtual eXtensible Local Area Network (VXLAN) (2018)

Ping is a widely deployed Operation, Administration, and Maintenance
(OAM) mechanism in networks. This document describes a mechanism for
detecting data-plane failures using Ping in RFC7348 VXLAN based EVPN
networks.
Detectability of reflectance and fluorescent contrast agents for real-time in vivo confocal microscopy (2002)

Reflectance agents (liposomes, polystyrene microparticles, aluminum chloride salts, acetic acid) and fluorescent agents (polymer-and cosmetic actives-tagged fluorescein and rhodamine compounds, green fluorescent protein) enhance contrast of real-time confocal images of skin and microcirculation in vivo. Quantitative analysis of signal detectability versus contrast agent properties, and experimental images are presented. These results provide a basis for optimizing confocal microscope design and imaging parameters for real-time in vivo applications.
Pax4 Paired Domain Mediates Direct Protein Transduction into Mammalian Cells (2007)

Pax4, a paired-box transcription factor, is a key regulator of pancreatic islet cell growth and differentiation. Here, we report for the first time that the Pax4 protein can permeate into various cell types including pancreatic islets. The paired domain of Pax4 serves as a novel protein transduction domain (PTD). The Pax4 protein can transduce in a dose- and time-dependent manner. The cellular uptake of Pax4 PTD can be completely blocked by heparin, whereas cytochalasin D and amiloride were partially effective in blocking the Pax4 protein entry. Transduced intact Pax4 protein functions similarly to the endogenous Pax4. It inhibits the Pax6 mediated transactivation and protects Min6 cells against TNFalpha-induced apoptosis. These data suggest that Pax4 protein transduction could be a safe and valuable strategy for protecting islet cell growth in culture from apoptosis and promoting islet cell differentiation.
Optimized static and video EEG rapid serial visual presentation (RSVP) paradigm based on motion surprise computation (2017)

In this paper, we describe an algorithm and system for optimizing search and detection performance for “items of interest” (IOI) in large-sized images and videos that employ the Rapid Serial Visual Presentation (RSVP) based EEG paradigm and surprise algorithms that incorporate motion processing to determine whether static or video RSVP is used. The system works by first computing a motion surprise map on image sub-regions (chips) of incoming sensor video data and then uses those surprise maps to label the chips as either “static” or “moving”. This information tells the system whether to use a static or video RSVP presentation and decoding algorithm in order to optimize EEG based detection of IOI in each chip. Using this method, we are able to demonstrate classification of a series of image regions from video with an azimuth value of 1, indicating perfect classification, over a range of display frequencies and video speeds.
Gene expression of glucose transporter (GLUT) 1, 3 and 4 in bovine follicle and corpus luteum (2006)

Glucose is the main energy substrate in the bovine ovary, and a sufficient supply of it is necessary to sustain the ovarian activity. Glucose cannot permeate the plasma membrane, and its uptake is mediated by a number of glucose transporters (GLUT). In the present study, we investigated the gene expression of GLUT1, 3 and 4 in the bovine follicle and corpus luteum (CL). Ovaries were obtained from Holstein x Japanese Black F1 heifers. Granulosa cells and theca interna layers were harvested from follicles classified into five categories by their physiologic status: follicular size (>or= 8.5 mm: dominant; < 8.5 mm: subordinate), ratio of estradiol (E(2)) to progesterone in follicular fluid (>or= 1: E(2) active;<1: E(2) inactive), and stage of estrous cycle (luteal phase, follicular phase). CL were also classified by the stage of estrous cycle. Expression levels of GLUT1, 3 and 4 mRNA were quantified by a real-time PCR. The mRNA for GLUT1 and 3 were detected in the bovine follicle and CL at comparable levels to those in classic GLUT-expressing organs such as brain and heart. Much lower but appreciable levels of GLUT4 were also detected in these tissues. The gene expression of these GLUT showed tissue- and stage-specific patterns. Despite considerable differences in physiologic conditions, similar levels of GLUT1, 3 and 4 mRNA were expressed in subordinate follicles as well as dominant E(2)-active follicles in both luteal and follicular phases, whereas a notable increase in the gene expression of these GLUT was observed in dominant E(2)-inactive follicles undergoing the atretic process. In these follicles, highly significant negative correlations were observed between the concentrations of glucose in follicular fluid and the levels of GLUT1 and 3 mRNA in granulosa cells, implying that the local glucose environment affects glucose uptake of follicles. These results indicate that GLUT1 and 3 act as major transporters of glucose while GLUT4 may play a supporting role in the bovine follicle and CL.
An Evaluation of a Full-Access Underbody Forced-Air Warming System During Near-Normothermic, On-pump Cardiac Surgery (2008)

Adding an underbody forced-air warming system to the near-normothermic thermal management protocol significantly increased pre-bypass temperature; however, it had no further clinically important effect on core temperature.
Future Trends in Hepatitis C Therapy (2005)

The development of new treatment strategies for the therapy of hepatitis C is an unmet need. There has already been an enormous improvement in the therapy of chronic hepatitis C since the early 1990s, but the sustained virologic response rates are still unsatisfactory for certain patient groups. Novel therapeutic strategies, especially for the difficult-to-treat patients, are currently being tested. This review discusses the latest achievements in the treatment of chronic heptatis C.
Two photon imaging of calcium responses in murine Purkinje neurons (2022)

Purkinje neurons (PNs) are an important component of the motor learning and coordination circuit and are affected in spino-cerebellar ataxias. Maintaining healthy PNs in cerebellar slices and recording their Ca<sup>2+</sup> transients can be challenging. Here, we describe a protocol for measuring Ca<sup>2+</sup> transients in PNs from adult mice, including problem-solving tips. This protocol can be used to measure neuronal excitability and agonist-mediated Ca<sup>2+</sup> signaling in cerebellar slices expressing a genetic Ca<sup>2+</sup> reporter in all PNs, thus improving yield of data. For complete details on the use and execution of this profile, please refer to Dhanya and Hasan (2021).
Measurement of the prompt-production cross-section ratio <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:mi>σ</mml:mi><mml:mrow><mml:mo>(</mml:mo><mml:msub><mml:mi>χ</mml:mi><mml:mrow><mml:mi>c</mml:mi><mml:mn>2</mml:mn></mml:mrow></mml:msub><mml:mo>)</mml:mo></mml:mrow><mml:mo>/</mml:mo><mml:mi>σ</mml:mi><mml:mrow><mml:mo>(</mml:mo><mml:msub><mml:mi>χ</mml:mi><mml:mrow><mml:mi>c</mml:mi><mml:mn>1</mml:mn></mml:mrow></mml:msub><mml:mo>)</mml:mo></mml:mrow></mml:mrow></mml:math> in <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mi>p</mml:mi><mml:mi>Pb</mml:mi></mml:math> collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"><mml:mrow><mml:msqrt><mml:msub><mml:mi>s</mml:mi><mml:mrow><mml:mi>N</mml:mi><mml:mi>N</mml:mi></mml:mrow></mml:msub></mml:msqrt><mml:mo>=</mml:mo><mml:mn>8.16</mml:mn></mml:mrow></mml:math> TeV (2021)

This article reports the first measurement of prompt ${\ensuremath{\chi}}_{c1}$ and ${\ensuremath{\chi}}_{c2}$ charmonium production in nuclear collisions at Large Hadron Collider energies. The cross-section ratio $\ensuremath{\sigma}({\ensuremath{\chi}}_{c2})/\ensuremath{\sigma}({\ensuremath{\chi}}_{c1})$ is measured in $p\mathrm{Pb}$ collisions at $\sqrt{{s}_{NN}}=8.16$ TeV, collected with the LHCb experiment. The ${\ensuremath{\chi}}_{c1,2}$ states are reconstructed via their decay to a $J/\ensuremath{\psi}$ meson, subsequently decaying into a pair of oppositely charged muons, and a photon, which is reconstructed in the calorimeter or via its conversion in the detector material. The cross-section ratio is consistent with unity in the two considered rapidity regions. Comparison with a corresponding cross-section ratio previously measured by the LHCb Collaboration in $pp$ collisions suggests that ${\ensuremath{\chi}}_{c1}$ and ${\ensuremath{\chi}}_{c2}$ states are similarly affected by nuclear effects occurring in $p\mathrm{Pb}$ collisions.
Security Governance, Management and Strategic Alignment via Capabilities (2017)

Stripped down to its essentials a business is a collection of capabilities organized to achieve a purpose. Exactly how well those capabilities are organized and optimized around a strategy impacts the performance of the entire enterprise [2]. Capabilities are the adhesive which holds together information security governance and organizational strategy [3]. There is a domino effect in that the potency of day-to-day security operations is a byproduct of a security management, which is a byproduct of security governance which is a byproduct of organizational governance. Organizational governance is concerned with ensuring the enterprise maintains alignment with its short and long-term strategic goals. Thus, the work of aligning security governance and organizational strategy is consonant with the work of recognizing which capabilities are aligned with short and long-term goals and ensuring those capabilities remain protected through a sound and comprehensive security governance and security management program.
High efficiency multichannel collimator for structural studies of liquids and low-Z materials at high pressures and temperatures (2011)

A high efficiency multichannel collimator (MCC) device has been developed at the high pressure beamline ID27 of the European Synchrotron Radiation Facility to drastically reduce the x-ray background from the sample environment in the Paris-Edinburgh press. The main technical difficulty, which resides in the minimum slits size achievable using the classical mono-bloc design, has been resolved using an original concept based on a set of independent slits. Then, a very small slit size of 50 μm was manufactured resulting in a great improvement of the signal to background ratio. In addition, the transfer function of the MCC has been measured using the x-ray diffusion signal of a metal doped glass and efficiently applied to correct the raw data. The potential of this new device is illustrated in two challenging examples: iron-sulfur liquid structures and C(60) polymerization process at high pressure and high temperature.
Splenic trauma as an adverse effect of torso-protection side airbags, biomechanical and case evidence (2009)

Injury mechanisms from frontal airbags, first identified in anecdotal reports, are now well documented for pediatric, small female, and out-of-position occupants. In contrast, torso side airbags have not yet been consistently associated with specific injury risks in field assessments. To determine possible torso side airbag-related injuries, the present study identified crashes involving side airbags from reports within the CIREN, NASS, and SCI databases. Injury patterns were compared to patterns from lateral crashes in absence of side airbag. Splenic trauma (AIS 3+) was found present in five cases of torso side airbag deployment at lower impact severity (as measured by velocity change and compartment intrusion) than cases of splenic trauma without side airbag. Five additional cases were found to contain similar injury patterns but occurred with greater crash severity. To supplement case analyses, full scale sled tests were conducted with a THOR-NT dummy and cadaveric specimen. Four THOR tests with door- and seat-mounted torso side airbags confirmed that out-of-position (early inflation stage) airbag contact elevated thoracic injury metrics compared to optimal (fully inflated) contact. Out-of-position seat-mounted airbag deployment also produced AIS 3 splenic trauma in the cadaveric specimen. Due to potentially sudden or delayed onset of intraperitoneal hemorrhage and hypovolemic shock following splenic trauma, further biomechanical investigation of this anecdotal evidence is essential to identify injury mechanisms, prevention techniques, and methods for early diagnosis.