gebhart/patrepeval huggingface dataset:
A Cell Number Counting Factor Regulates Akt/Protein Kinase B To Regulate <i>Dictyostelium discoideum</i> Group Size (2004)

Little is known about how individual cells can organize themselves to form structures of a given size. During development, Dictyostelium discoideum aggregates in dendritic streams and forms groups of approximately 20,000 cells. D. discoideum regulates group size by secreting and simultaneously sensing a multiprotein complex called counting factor (CF). If there are too many cells in a stream, the associated high concentration of CF will decrease cell-cell adhesion and increase cell motility, causing aggregation streams to break up. The pulses of cyclic AMP (cAMP) that mediate aggregation cause a transient translocation of Akt/protein kinase B (Akt/PKB) to the leading edge of the plasma membrane and a concomitant activation of the kinase activity, which in turn stimulates motility. We found that countin- cells (which lack bioactive CF) and wild-type cells starved in the presence of anticountin antibodies (which block CF activity) showed a decreased level of cAMP-stimulated Akt/PKB membrane translocation and kinase activity compared to parental wild-type cells. Recombinant countin has the bioactivity of CF, and a 1-min treatment of cells with recombinant countin potentiated Akt/PKB translocation to membranes and Akt/PKB activity. Western blotting of total cell lysates indicated that countin does not affect the total level of Akt/PKB. Fluorescence microscopy of cells expressing an Akt/PKB pleckstrin homology domain-green fluorescent protein (PH-GFP) fusion protein indicated that recombinant countin and anti-countin antibodies do not obviously alter the distribution of Akt/PKB PH-GFP when it translocates to the membrane. Our data indicate that CF increases motility by potentiating the cAMP-stimulated activation and translocation of Akt/PKB.
Production of nanoparticles by laser-induced ablation of metals in liquids (2003)

The production of noble metal (Ag and Au) nanoparticles upon the ablation of metal targets in liquids (H2O, C2H5OH, etc.) caused by irradiation by a copper vapour laser is studied. The nanoparticles emerging in a liquid are investigated using X-ray diffractometry, optical absorption spectroscopy, and high-resolution transmission electron microscopy. The colloidal nanoparticle solutions exhibits a distinct plasmon resonance at 520 and 400 nm for Au and Ag, respectively. It is shown that the proximity of laser wavelength to the resonance makes it possible to decrease the dimension of nanoparticles by irradiating the colloidal solution. The size distribution function of nanoparticles is simulated taking into account the production, coagulation, and splitting of nanopartiles in the laser beam.
Pinched hysteresis loops in non‐linear resonators (2020)

Abstract This study shows that pinched hysteresis can be observed in simple non‐linear resonance circuits containing a single diode that behaves as a voltage‐controlled switch. Mathematical models are derived and numerically validated for both series and parallel resonator circuits. The lobe area of the pinched loop is found to increase with increased frequency and multiple pinch points are possible with an odd‐symmetrical non‐linearity such as a cubic non‐linearity. Experiments have been performed to prove the existence of pinched hysteresis with a single diode and with two anti‐parallel diodes. The formation of a pinched loop in these circuits confirms the following: (1) pinched hysteresis is not a fingerprint of memristors, and (2) the existence of a non‐linearity is essential for generating this behaviour. Finally, an application in a digital logic circuit is validated.
QSARs and Three-Dimensional Shape Studies of Fungicidal Azolylmethylcyclopentanols (1995)

A series of azole compounds containing a cyclopentane ring were synthesized and tested for fungicidal activity. The Hansch-Fujita type QSAR and three-dimensional shape comparison analyses were employed to optimize the structure of a lead compound logically for the higher fungicidal activity, resulting in the discovery of metconazole and ipconazole, promising fungicides of novel structure. A possible mode of interaction between metconazole and its target receptor, cytochrome P45014DM was proposed.
Structure and Expression of Mouse VL30 Genes (1983)

DNA sequencing and blot hybridization analyses have been used to study the structure of a mouse VL30 gene and the molecular nature of VL30-related RNA which is induced upon the stimulation of cultured AKR mouse embryo cells with defined peptide growth factors. An integrated mouse VL30 gene was found to contain identical 601-base-pair long terminal repeats (LTRs) which were themselves terminated in short inverted repeats. The entire VL30 gene was flanked by a 4-base-pair direct repeat of cellular DNA. Thus, VL30 genes are structurally analogous to integrated forms of retrovirus proviruses and certain other classes of mobile genetic elements. The LTR sequence was found to contain putative promoter and polyadenylation signals and generally exhibited little sequence homology to murine leukemia virus proviral LTRs. Certain short regions of sequence conservation, however, were evident, including the inverted terminal repeat, LTR-adjacent regions corresponding to origins of murine leukemia virus proviral DNA synthesis, and a 36-base-pair direct repeat bearing homology to the 72-base-pair direct repeat (enhancer sequence) of the murine leukemia virus-related Moloney sarcoma virus. Upon mitogenic stimulation of quiescent cells with epidermal growth factor and insulin, a major 5.5-kilobase VL30-specific RNA complementary to both LTR and non-LTR sequences was rapidly induced. We conclude that a complete VL30 gene(s) is highly regulated by peptide growth factor binding to specific membrane receptors in these cells.
Scaling multi-core network processors without the reordering bottleneck (2014)

Today, designers of network processors strive to keep the packet reception and transmission orders identical, and therefore avoid any possible out-of-order transmission. However, the development of new features in advanced network processors has resulted in increasingly parallel architectures and increasingly heterogeneous packet processing times, leading to large reordering delays. In this paper, we introduce novel scalable scheduling algorithms for preserving flow order in parallel multi-core network processors. We show how these algorithms can reduce reordering delay while adapting to any load-balancing algorithm and keeping a low implementation complexity overhead. To do so, we use the observation that all packets in a given flow have similar processing requirements and can be described with a constant number of logical processing phases. We further define three possible knowledge frameworks of the time when a network processor learns about these logical phases, and deduce appropriate algorithms for each of these frameworks.
Enhanced localization coverage with non-regenerative UWB relays (2012)

Real-time locating systems (RTLS) enable a number of new important applications. Their performance is mainly limited by wireless propagation impairments. This paper puts forth the idea to enhance coverage and accuracy of RTLS in the presence of severe non line-of-sight propagation conditions using low complexity non-regenerative ultra-wide bandwidth relays. A maximum likelihood position estimator is derived and the feasibility of relay-based positioning scheme is demonstrated.
Properties of Ascorbate Oxidase Produced by<i>Acremonium</i>sp. HI-25 (1995)

Journal Article Properties of Ascorbate Oxidase Produced by Acremonium sp. HI-25 Get access Homare Itoh, Homare Itoh Department of Applied Microbial Technology, The Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Akira Hirota, Akira Hirota Department of Applied Microbial Technology, The Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, JapanSchool of Food and Nutritional Sciences, University of Shizuoka, Yada, Shizuoka 422, Japan Search for other works by this author on: Oxford Academic Google Scholar Kazuo Hirayama, Kazuo Hirayama Department of Applied Microbial Technology, The Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Takashi Shin, Takashi Shin Department of Applied Microbial Technology, The Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Sawao Murao Sawao Murao Department of Applied Microbial Technology, The Kumamoto Institute of Technology, Ikeda 4–22–1, Kumamoto 860, Japan Search for other works by this author on: Oxford Academic Google Scholar Bioscience, Biotechnology, and Biochemistry, Volume 59, Issue 6, 1 January 1995, Pages 1052–1056, https://doi.org/10.1271/bbb.59.1052 Published: 01 January 1995 Article history Received: 02 November 1994 Published: 01 January 1995
Extending the Frontier of Quantum Computers With Qutrits (2020)

We advocate for a fundamentally different way to perform quantum computation by using three-level qutrits instead of qubits. In particular, we substantially reduce the resource requirements of quantum computations by exploiting a third state for temporary variables (ancilla) in quantum circuits. Past work with qutrits has demonstrated only constant factor improvements, owing to the log2(3) binary-to-ternary compression factor. We present a novel technique using qutrits to achieve a logarithmic runtime decomposition of the Generalized Toffoli gate using no ancilla---an exponential improvement over the best qubit-only equivalent. Our approach features a 70x improvement in total two-qudit gate count over the qubit-only decomposition. This results in improvements for important algorithms for arithmetic and QRAM. Simulation results under realistic noise models indicate over 90% mean reliability (fidelity) for our circuit, versus under 30% for the qubit-only baseline. These results suggest that qutrits offer a promising path toward extending the frontier of quantum computers.
60‐3: High‐Performance MoS <sub>2</sub> Thin‐Film Transistors for Flexible OLED display (2018)

We demonstrated Molybdenum disulfide (MoS 2 ) based thin‐film transistors on polyimide substrate for flexible OLED display. And we fabricated practical MoS 2 OLED driving circuit using large area MoS 2 thin film grown by chemical vapor deposition (CVD) method. Our device showed high‐performance for display driving circuit over 10 μA driving current, on‐off ratio of 10 9 . And the 2T OLED driving operation test was also conducted. In this work, we will show results suitable for practical flexible OLED display.
Effect of internal laser radiation on the buildup of ionization instability of a nonself-sustained discharge exciting excimer lasers (1979)

It is shown that the laser self-emission of a medium may have a substantial influence on the time behavior of the various plasma components of a nonself-sustained gas discharge exciting excimer lasers.
How Young Can Our Technology Design Partners Be (2002)

For this work-in-progress presentation, we report on our experiences working with young children as technology design partners. Our team from the Human-Computer Interaction Lab has extensive participatory design experience in working with 7-11 year old children. Here we describe our first year working with 4-6 year old children and the ways that we altered our methodologies to meet the unique needs of our younger design partners.
3,4-Alkylenedioxypyrrole-Based Conjugated Polymers with Finely Tuned Electronic and Optical Properties via a Flexible and Efficient <i>N</i>-Functionalization Method (2007)

The poly(3,4-alkylenedioxypyrrole) family of conjugated polymers (the PXDOPs) shows potential for widespread applications due to their unique electronic and optical properties; however, progress has been limited due to synthetic limitations. We report an optimized synthetic route for a new compound, 3,4-propyledioxypyrrole-N-acetic acid (ProDOP-N-AcOH), which utilizes inexpensive reagents, high yielding steps that require little or no purification (and no chromatography), and which can be converted, using either one or two facile synthetic transformations, to a variety of ester, alcohol, and ether derivatives. The derivatives were electropolymerized onto Pt button working electrodes, and it was found that the polymers containing ester N-pendant groups exhibited a peak monomer oxidation potential 100 mV higher than that of the ethers, suggesting an inductive effect. Polymer E1/2 values were measured to be between −0.24 and 0.01 V and were highly dependent on polymer pendant group structure and electrochemical media. HOMO values measured by DPV were found to be relatively independent of polymer structure. All monomers were electropolymerized onto transparent ITO/glass anodes for the purpose of generating electrochromic films. The predominant electrochromic processes occurred in the near-IR and UV regions, suggesting that they may be candidate materials for electrochromic applications outside the visible spectrum. The polymer containing a hydroxyl pendant group exhibited a brilliant red color upon both light and heavy doping and was transmissive upon dedoping. The strong absorbance in the visible region, the high band gap of 3.40 eV, and the passivating electrochemistry may be due to the formation of a tight polymer network, cross-linked through hydrogen-bonding interactions.
BeiDou 3 signal quality analysis and its impact on users (2019)

This work presents signal analysis results based on observations of the new BeiDou 3 signals, which appeared in the years 2017 to 2019. After a brief introduction of the measurement facility, the basic analysis of the quality of the signals in spectral and modulation domains is introduced. This covers the transition from BeiDou 2 up to BeiDou 3 including the test and validation phase at the beginning of BeiDou 3. On the basis of captured in-phase (I) and quadrature (Q) samples, a detailed overview of the BeiDou 3 satellite payload characteristics including signal deformation analysis is provided. This work also assesses how such imperfections will influence the pseudorange measurements and consequently provide the capability for an error analysis for safety-critical applications. Considering the measured power in relation to the boresight angle of the satellite, a cut through the antenna pattern of different satellites is presented, and the antenna symmetry properties are assessed.
950 MHz, -60dB TX-Cancellation Active Directional Couplers for UHF RFID Application (2011)

We propose two types of active directional couplers to assure high TX cancellation: an asymmetric type and a symmetric type. For attaining low receiving through loss, coupling capacitors used in conventional couplers are replaced by amplifiers in the proposed active directional couplers. The asymmetric active directional coupler is composed of a small number of components and simple structure. The symmetric active directional coupler has wide-bandwidth TX cancellation. Measurement results show that receiving through loss of -5.3dB and the TX cancellation of -67.6dB are obtained in the asymmetric active directional coupler, and receiving through loss of -6.7dB and the TX cancellation of -66.4dB are obtained in the symmetric active directional coupler. Compared to the asymmetric active directional coupler, the symmetric active directional coupler has advantage of wider bandwidth of 1.25MHz to reduce TX leakage of less than -55dB. Both the proposed active directional couplers achieve high TX cancellation, and the symmetric active directional coupler can be applied in a UHF RFID system with 10-m communication range.
Pulsed free space two-port photonic vector network analyzer with up to 2 THz bandwidth (2021)

We demonstrate a free space two-port photonic vector network analyzer capable of measuring the scattering parameters of devices and materials in the terahertz range with a frequency coverage of 0.2 - 2 THz in a single system. It is based on photoconductive terahertz sources and detectors driven by a telecom-wavelength femtosecond laser. Being able to cover a bandwidth of one order of magnitude, the system is capable of performing S-parameter measurements deep into the terahertz range, beyond frequencies reachable by their electronic counterparts. We demonstrate high performance at three application examples, namely S-parameter measurements of a split ring resonator array and a distributed Bragg reflector, as well as material parameter extraction of several materials.
Tunneling conduction in Co-cluster/tetraoctylammonium bromide/poly(phenyl-<i>p</i>-phenylenevinylene) nanocomposites (1995)

A system of nanometer sized cobalt clusters surrounded by dielectric shells has been investigated by electrical dc conductivity measurements. The cobalt clusters have a diameter of 36 Å and are surrounded by an approximately 12-Å-thick layer of tetra-octyl-ammonium bromide surfactant molecules and poly(phenyl-p-phenylenevinylene). The conductivity σ shows a temperature dependence ln(σ)∝(T0/T)1/2 in the range 100&amp;lt;T&amp;lt;240 K. At T≳240 K, the temperature dependence of the conductivity demonstrates some peculiarities. Differential scanning analysis suggests that at 240&amp;lt;T&amp;lt;350 K phase transitions of the composite material take place. The observed temperature dependence of the conductivity σ for T&amp;lt;240 K is typical for hopping conduction in granular metallic systems. A theoretical analysis shows that the data are consistent with a hopping model in which the separation between grains is a random variable uncorrelated with the activation energy. The observed nonlinear dependence of the conductivity on the electric field F is interpreted in the framework of the concept of the effective temperature, which suggests that the influence of T and F on σ can be parameterized by a single quantity Teff(T,F). Comparison between the theoretical results and experimental data provides a suitable expression for Teff(T,F).
Fine mapping of breast cancer genome-wide association studies loci in women of African ancestry identifies novel susceptibility markers (2013)

Numerous single nucleotide polymorphisms (SNPs) associated with breast cancer susceptibility have been identified by genome-wide association studies (GWAS). However, these SNPs were primarily discovered and validated in women of European and Asian ancestry. Because linkage disequilibrium is ancestry-dependent and heterogeneous among racial/ethnic populations, we evaluated common genetic variants at 22 GWAS-identified breast cancer susceptibility loci in a pooled sample of 1502 breast cancer cases and 1378 controls of African ancestry. None of the 22 GWAS index SNPs could be validated, challenging the direct generalizability of breast cancer risk variants identified in Caucasians or Asians to other populations. Novel breast cancer risk variants for women of African ancestry were identified in regions including 5p12 (odds ratio [OR] = 1.40, 95% confidence interval [CI] = 1.11-1.76; P = 0.004), 5q11.2 (OR = 1.22, 95% CI = 1.09-1.36; P = 0.00053) and 10p15.1 (OR = 1.22, 95% CI = 1.08-1.38; P = 0.0015). We also found positive association signals in three regions (6q25.1, 10q26.13 and 16q12.1-q12.2) previously confirmed by fine mapping in women of African ancestry. In addition, polygenic model indicated that eight best markers in this study, compared with 22 GWAS-identified SNPs, could better predict breast cancer risk in women of African ancestry (per-allele OR = 1.21, 95% CI = 1.16-1.27; P = 9.7 × 10(-16)). Our results demonstrate that fine mapping is a powerful approach to better characterize the breast cancer risk alleles in diverse populations. Future studies and new GWAS in women of African ancestry hold promise to discover additional variants for breast cancer susceptibility with clinical implications throughout the African diaspora.
35.3: <i>Invited Paper</i> : The Soluble Hole Injection Materials and the Inks Applicable to OLED Devices (2014)

Abstract We are developing the soluble hole injection materials and the ink, named ELsource® that can be used as hole injection layer in OLED devices. Optimization of solvent composition applicable to wet coating process and new hole injection material with higher transmittance are reported.
Enhanced Smooth Hysteretic Model with Degrading Properties (2012)

The elastic and inelastic nonlinear behavior of structural members use constitutive relations in which restoring forces and deformations are not proportional and often follow different paths in loading and unloading using hysteretic functions. There are numerous available models that can trace the stiffness and strength changes through yielding, softening, and hardening; however, models that can address more complex behavior such as degradations, large deformation, bond slip, and joint gap, do so by complex polygonal rules or smooth continuous functions describing momentary (tangent) behavior. There is a need for a unified model on the basis of a combination of mechanical springs that can trace the instantaneous combined stiffness used in system analyses. In this study, a one-dimensional smooth hysteretic model using series and parallel springs, designed for nonlinear structural analysis, is enhanced to incorporate (1) time-independent properties, (2) nonlinear elastic and postelastic softening and hardening, (3) sudden or continuous variation of strength, (4) degradation of elastic and inelastic stiffness, (5) a modified bond-slip model, and (6) an alternative joint-gap model with a variable gap closing length. Using spring analogues or reciprocal structures, the instantaneous force-displacement incremental relations are formulated, which can be further used to determine the instantaneous tangent-stiffness matrices of the elements used in the analyses of complex structures.
Genesis 4-D Project Status and Preliminary Lookback (2005)

Abstract A 4D seismic survey was acquired over Genesis Field, deepwater Gulf of Mexico, in October, 2002 specifically for reservoir monitoring and field management. The acquisition criteria replicate the pre-production baseline survey. Coprocessing baseline and monitor surveys minimized differences between surveys except those related to production. Interpretation of reflection and acoustic impedance volumes indicate that the 4D project will add significant value to the field. The interpretation of 4D data on the field's five primary reservoir sands has resulted in: • Observed production-related time-lapse anomalies including a) changes in reflection strength due to fluid movement and pressure reduction b) an increase in travel time of up to 10 ms at the top of the producing interval due to reservoir compaction and overburden dilation. • Identification of up dip potential and/or its risk reduced in three reservoirs. • Resolved connectivity uncertainties in several reservoirs leading to better understanding and modeling of reservoir behavior. Preliminary assessment of the 4D project indicates significant value added by modifying field operations: • One anticipated sidetrack has been eliminated saving over $10 million dollars. • The geological risk of one sidetrack was reduced and the original estimate of recoverable volumes increased. At least two future sidetracks should be affected similarly. • Adjustments to the reservoir simulation should lead to better well placement, improved recovery estimates, and better reservoir management.