gebhart/patrepeval huggingface dataset:
Streptococcus pneumoniae Phosphoglycerate Kinase Is a Novel Complement Inhibitor Affecting the Membrane Attack Complex Formation (2014)

The Gram-positive bacterium Streptococcus pneumoniae is a major human pathogen that causes infections ranging from acute otitis media to life-threatening invasive disease. Pneumococci have evolved several strategies to circumvent the host immune response, in particular the complement attack. The pneumococcal glycolytic enzyme phosphoglycerate kinase (PGK) is both secreted and bound to the bacterial surface and simultaneously binds plasminogen and its tissue plasminogen activator tPA. In the present study we demonstrate that PGK has an additional role in modulating the complement attack. PGK interacted with the membrane attack complex (MAC) components C5, C7, and C9, thereby blocking the assembly and membrane insertion of MAC resulting in significant inhibition of the hemolytic activity of human serum. Recombinant PGK interacted in a dose-dependent manner with these terminal pathway proteins, and the interactions were ionic in nature. In addition, PGK inhibited C9 polymerization both in the fluid phase and on the surface of sheep erythrocytes. Interestingly, PGK bound several MAC proteins simultaneously. Although C5 and C7 had partially overlapping binding sites on PGK, C9 did not compete with either one for PGK binding. Moreover, PGK significantly inhibited MAC deposition via both the classical and alternative pathway at the pneumococcal surface. Additionally, upon activation plasmin(ogen) bound to PGK cleaved the central complement protein C3b thereby further modifying the complement attack. In conclusion, our data demonstrate for the first time to our knowledge a novel pneumococcal inhibitor of the terminal complement cascade aiding complement evasion by this important pathogen.
Living cationic polymerization of amide‐functional vinyl ethers: Specific properties of SnCl<sub>4</sub>‐based initiating system (2008)

Abstract Living cationic copolymerization of amide‐functional vinyl ethers with isobutyl vinyl ether (IBVE) was achieved using SnCl 4 in the presence of ethyl acetate at 0 °C: the number–average molecular weight of the obtained polymers increased in direct proportion to the monomer conversion with relatively low polydispersity, and the amide‐functional monomer units were introduced almost quantitatively. To optimize the reaction conditions, cationic polymerization of IBVE in the presence of amide compounds, as a model reaction, was also examined using various Lewis acids in dichloromethane. The combination of SnCl 4 and ethyl acetate induced living cationic polymerization of IBVE at 0 °C when an amide compound, whose nitrogen is adjacent to a phenyl group, was used. The versatile performance of SnCl 4 especially for achieving living cationic polymerization of various polar functional monomers was demonstrated in this study as well as in our previous studies. Thus, the specific properties of the SnCl 4 initiating system are discussed by comparing with the Et x AlCl 3− x systems from viewpoints of hard and soft acids and bases principle and computational chemistry. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 6129–6141, 2008
Fitting of the Hearing System Affects Partial Deafness Cochlear Implant Performance (2010)

(2010). Fitting of the Hearing System Affects Partial Deafness Cochlear Implant Performance. Cochlear Implants International: Vol. 11, Proceedings of the 9th European Symposium on Paediatric Cochlear Implantation, Warsaw, 2009, pp. 117-121.
A new invariant characterizing the postural alignment of young healthy adults (2015)

International audience
A novel prognostic model for patients with sarcomatoid renal cell carcinoma (2014)

Among patients with grade 4 RCC, either with or without distant metastases at surgery, sarcomatoid differentiation is significantly associated with adverse survival in a multivariate setting. We also suggest for the first time that the percentage of sarcomatoid differentiation is an independent prognostic feature in a multivariate setting. The 2009 primary tumour classifications, regional lymph node status, the presence of distant metastases classifications, coagulative tumour necrosis, and the amount of sarcomatoid differentiation are independent predictors of survival for patients with sarcomatoid RCC.
Finding new drugs to enhance anion secretion in cystic fibrosis: Toward suitable systems for better drug screening. Report on the pre-conference meeting to the 12th ECFS Basic Science Conference, Albufeira, 25–28 March 2015 (2015)

Multidisciplinary approaches were described in this preconference meeting for enabling discovery of novel small molecules that target mutant CFTR in addition to other channels and pathways important for improving fluid secretion in CF-affected epithelia. The ability of these new approaches to discover therapies for F508del patients that are superior to Orkambi™ has yet to be determined. Progress toward this goal will not only require continued advances in developing sensitive in-vitro assays of patient responses to emerging compounds but also new clinical assay development and methods to better correlate patient responses in-vitro and in-vivo responses. This theme is highly likely to figure prominently in CF conferences in the near future.
Reversible Topochemical Transformation of a Soft Crystal of a Coordination Polymer (2007)

Shaping up: The two isomorphous 2D hybrid frameworks {[Ln(tci)(H2O)2]⋅2 H2O}n (Ln=CeIII or PrIII, tciH3=tris(2-carboxyethyl)isocyanurate) were prepared using a highly flexible ligand. The frameworks show a single crystal to single crystal topochemical transformation from a two-dimensional (2D) to three-dimensional (3D) framework and vice versa (see picture) and exhibits selective adsorption properties of H2O over MeOH and EtOH. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z703086_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
A full parity phase diagram of a Majorana island (2020)

We measure the charge periodicity of Coulomb blockade conductance oscillations of a hybrid InSb-Al island as a function of gate voltage and parallel magnetic field. The periodicity changes from $2e$ to $1e$ at a gate-dependent value of the magnetic field, $B^*$, decreasing from a high to a low limit upon increasing the gate voltage. In the gate voltage region between the two limits, which our numerical simulations indicate to be the most promising for locating Majorana zero modes, we observe correlated oscillations of peak spacings and heights. Our measurements demonstrate the importance of a careful exploration of the entire available phase space of a proximitized nanowire as a prerequisite to define future topological qubits.
Application du Codage Réseau aux Architectures à Garanties de QoS (2010)

L'interet du codage reseau (network coding) pour ameliorer le debit ou optimiser l'utilisation de la capacite du reseau a ete clairement demontre dans differents contextes. Certains travaux ont notamment montre que le codage reseau permet de diminuer le delai (maximal et moyen) de transmission de bout-en- bout d'un paquet. Ceci est du au fait que le traitement simultane de plusieurs paquets dans un noeud de codage permet de reduire le temps passe par les paquets dans les files d'attente par rapport au routage classique. Dans ce travail, nous considerons l'application du codage reseau dans le contexte des reseaux proposant des garanties de qualite de service (QoS). Notre principale contribution est la proposition de trois strategies de codage reseau assurant un niveau de QoS garantie exprime en termes de delai de bout-en-bout.
Distributions, conservation status, and abiotic stress tolerance potential of wild cucurbits (<i>Cucurbita</i> L.) (2019)

Societal Impact Statement Crop wild relatives—wild species closely related to cultivated plants—are valuable genetic resources for crop improvement, but gaps in knowledge constrain their conservation and limit their further use. We develop new information on the distributions, potential breeding value, and conservation status of the 16 known wild relatives of cultivated pumpkins, squashes, zucchini, and gourds ( Cucurbita L.). The taxa occur from the central USA to Central America, plus two South American species, with the greatest richness in central Mexico and the western borderlands between Mexico and the USA. We determine the majority of species are of medium priority for conservation, both with regard to collecting for ex situ maintenance, and for enhanced habitat protection. Summary Crop wild relatives are valuable genetic resources for crop improvement. Knowledge gaps, including with regard to taxonomy, distributions, and characterization for traits of interest constrain their use in plant breeding. These deficiencies also affect conservation planning, both with regard to in situ habitat protection, and further collection of novel diversity for ex situ maintenance. Here we model the potential ranges of all 16 known wild cucurbit taxa ( Cucurbita L.), use ecogeographic information to infer their potential adaptations to abiotic stresses, and assess their ex situ and in situ conservation status. The taxa occur from the central USA to Central America, plus two South American species. Predicted taxon richness was highest in central Mexico and in the western borderlands between Mexico and the USA. We find substantial ecogeographic variation both across taxa and among populations within taxa, with regard to low temperatures, high and low precipitation, and other adaptations of potential interest for crop breeding. We categorize 13 of the taxa medium priority for further conservation as a combination of the ex situ and in situ assessments, two low priority, and one sufficiently conserved. Further action across the distributions of the taxa, with emphasis on taxonomic richness hotspots, is needed to comprehensively conserve wild Cucurbita populations.
38.4-Tbps Inline-amplified Transmission Using PPLN-based Optical Parametric Amplifier over 6 THz within L- and U-bands (2023)

We demonstrate a 5×80-km WDM transmission over 6 THz within 1597.19–1649.93 nm. PPLN-based optical parametric amplifiers provide sufficient gain for inline amplification of 60-channel 640-Gbps/ λ signals allocated in L- and U-bands.
Primary intracranial dural lymphoma of mucosa-associated lymphoid tissue (MALT) type: report of one case and review of the literature. (2005)

Primary indolent leptomeningeal lymphoma is a rare entity, and corresponds in most cases to mucosa-associated lymphoid tissue (MALT) type lymphoma. We are reporting a case of a 75 years old woman, who presented with a 2-year history of behavioral disorder, progressive memory loss and aphasia. Neuroimaging showed a mass infiltrating the frontal circumvolutions and the roof of the orbit. The biopsy revealed an infiltration of the dura by an indolent lymphoma, characteristic of a MALT-type lymphoma. Complete staging work-up did not show any evidence of systemic involvement. A treatment with systemic methotrexate, combined with intrathecal chemotherapy and followed by radiotherapy (30,6 Gy) of the primary site, was conducted. The 3-year follow-up confirms the persistent remission, the patient remaining well and free of symptoms. The review of the literature highlights the importance to recognize the indolent PLML as a distinct clinical entity, which exhibits a rather good prognosis following a relatively non-toxic therapy.
Programming Telecommunication Networks (1997)

The recent move towards market deregulation and open competition has sparked a wave of serious introspection in the telecommunications service industry. Telecom providers and operators are now required to open up their primary revenue channels to competing industries. In this paper, we examine the service structure of two major global communication networks — the Telephone Network and the Internet and explore their weaknesses and strengths. Building upon the experience we gained during the development of the initial xbind prototypes, we discuss the realization of an open programable networking environment based on a new service architecture for advanced telecommunication services. Our approach to the problem stems from two angles — one conceptual, the other implementational. In the first, we attempt to develop a service model that is open and reflects the economic market structure of the future telecommunications service industry. We believe that investigating such a model will help clarify some of the pertinent issues confronting the telecommunications service industry today as it comes of age. An engineering model for realizing the service market model is proposed as a vehicle for creating multimedia services on broadband networks. In the second, we investigate the feasibility of engineering this model from an implementation standpoint. We address some of the important issues fully aware that our work has opened new vistas that call for additional research. We believe that our work will lead to a major shift of paradigm in research and development of service architectures for telecommunication networks. It has already found strong resonance with the members of the OPENSIG international working group and its foundations have been proposed for possible standardization by Nortel.
Normalized 3D to 2D model-based facial image synthesis for 2D model-based face recognition (2011)

In our previous research, we created a database of 3D textured face models of people using stereo images and a generic face mesh model for 3D face recognition application. Consequently, in this paper we make use of this available database and propose an algorithm for synthesizing multiple view 2D facial images of each subject, which extends the number of images used in the training stage of a 2D face recognition system. The main contributions of our work are: a) proposing a novel 3D model-based face pose and scale normalizations before creating the synthesized 2D database from its 3D counterpart and b) proposing a model-based facial area segmentation and normalization to a given 2D probe facial image. Recognition experiments, using near frontal probe facial images and the extended synthesized database, demonstrate improved 2D recognition rate.
Crowdsourcing General Computation (2011)

We present a direction of research on principles and methods that can enable general problem solving via human computation systems. A key challenge in human computation is the effective and efficient coordination of problem solving. While simple tasks may be easy to partition across individuals, more complex tasks highlight challenges and opportunities for more sophisticated coordination and optimization, leveraging such core notions as problem decomposition, subproblem routing and solution, and the recomposition of solved subproblems into solutions. We discuss the interplay between algorithmic paradigms and human abilities,and illustrate through examples how members of a crowd can play diverse roles in an organized problem-solving process, serving not only as "data oracles" at the endpoints of computation, but also as modules for decomposing problems, controlling the algorithmic progression, and performing human program synthesis.
Interaction Between Conjunctival Epithelial Cells and Mast Cells Induces CCL2 Expression and Piecemeal Degranulation in Mast Cells (2013)

Mast cell-conjunctival epithelial cell interaction induces CCL2 expression and subsequent PMD.
Activation of <scp>KIT</scp> modulates the function of tumor necrosis factor‐related apoptosis‐inducing ligand receptor (TRAIL‐R) in mast cells (2015)

Activation of KIT regulates the function of TRAIL-Rs in MCs. TRAIL-R1 may represent an attractive diagnostic and therapeutic target in diseases associated with KIT mutations, such as mastocytosis.
Bone grafts: a radiologic, histologic, and biomechanical model comparing autografts, allografts, and free vascularized bone grafts. (1984)

We developed an experimental model to compare the efficacy of free vascularized bone grafts, conventional segmental autografts, matchstick autografts, and fresh segmental allografts in terms of their ability to reconstruct a 7-cm segmental diaphyseal defect created in the canine femur. Forty-five adult mongrel dogs were studied and followed for 6 to 12 months prior to sacrifice. Evaluation included radiologic assessment of graft incorporation and hypertrophy, histology, and biomechanical testing. These studies indicated that microsurgically revascularized autografts were superior to all other groups in terms of early incorporation, hypertrophy, and the highest mechanical strength to failure. Union of the bone graft to the recipient femur was achieved by 6 months in 25 of 26 autografts, and no difference in union rate was seen within the autograft group. However, only two of five allografts achieved bony union during this time interval. Arteriography, microangiography, fluorochrome, and histologic studies all supported the concept that microsurgically revascularized grafts, when successful, maintain their viability. However, the premise that all osteocytes survive in a successfully revascularized bone graft is open to question. While decalcified sections showed that all microsurgically revascularized grafts maintained normal viability in the central marrow and cancellous portions compared with the other three groups, the viability of cortical bone in the vascularized autografts was less clear. Undecalcified fluorochrome sections suggested that circulation was not preserved in all portions of the cortex. Revascularization of the nonvascularized autografts was complete at 3 months, while, in the avascular allografts, the process was not complete at 6 months.
Structural Modeling of Dahlia-Type Single-Walled Carbon Nanohorn Aggregates by Molecular Dynamics (2013)

The structure of dahlia-type single-walled carbon nanohorn aggregates has been modeled by classical molecular dynamics simulations, and the validity of the model has been verified by neutron diffraction. Computer-generated models consisted of an outer part formed from single-walled carbon nanohorns with diameters of 20-50 Å and a length of 400 Å and an inner turbostratic graphite-like core with a diameter of 130 Å. The diffracted intensity and the pair correlation function computed for such a constructed model are in good agreement with the neutron diffraction experimental data. The proposed turbostratic inner core explains the occurrence of the additional (002) and (004) graphitic peaks in the diffraction pattern of the studied sample and provides information about the interior structure of the dahlia-type aggregates.
Feature Correction of a Topologically optimized Mode Demultiplexer Using Deep Neural Networks (2022)

We present a machine learning model to correct for fabrication variations in a topologically optimized mode demultiplexer and minimize its fabrication-induced performance degradation. The corrected design promises ~51% reduction in the insertion loss and an average reduction of crosstalk by 6 dB in simulation.
TGF-β signaling is an effective target to impair survival and induce apoptosis of human cholangiocarcinoma cells: A study on human primary cell cultures (2017)

at a dose of 10 μM, CX4945 significantly decreased cell viability of primary human cell cultures from both mucin and mixed CCA, whereas in CK19-positive cell cultures, the effect of CX4945 on cell viability required higher concentrations (>30μM). At the same concentrations, CX4945 also induced apoptosis (3- fold increase vs controls) which correlated with the expression level of CK2 in the different CCA cell lines (mucin- and mixed-CCA). Indeed, no apoptotic effects were observed in CK19-positive cells expressing lower CK2 levels. The effects of CX4945 on viability and apoptosis were associated with an increased number of γ-H2ax (biomarker for DNA double-strand breaks) foci, suggesting the active role of CK2 as a repair mechanism in CCAs. LY2157299 failed to influence cell proliferation or apoptosis but significantly inhibited cell migration. At a 50 μM concentration, in fact, LY2157299 significantly impaired (at 24, 48 and 120 hrs) the wound-healing of primary cell cultures from both mucin-and mixed-CCA. In conclusion, we demonstrated that CX4945 and LY2157299 exert relevant but distinct anticancer effects against human CCA cells, with CX4945 acting on cell viability and apoptosis, and LY2157299 impairing cell migration. These results suggest that targeting the TGF-β signaling with a combination of CX-4945 and LY2157299 could have potential benefits in the treatment of human CCA.
A bio‐inspired approach for regulating and measuring visco‐elastic properties of a robot arm (2005)

Abstract This work focuses on interaction control of robot manipulators in unstructured environments, with special regard for situations of unpredictable contact/noncontact transitions. It is basically addressed to those environments where a high level of robot adaptability is required and no information on the geometry of the environment is available. By pointing out the main limitations of standard interaction control schemes in managing situations of contact/noncontact transitions, this paper proposes a new control solution that is inspired by the biological model of motor control in voluntary movements. It consists of a combination of a feedforward loop and a proportional‐derivative plus gravity compensation control in the feedback loop. The control law is named coactivation‐based compliance control in the joint space since a unique function, called coactivation function, is evaluated for regulating robot visco‐elasticity in an unpredictably variable environment. It resumes the mechanism of adjustable visco‐elastic properties acting on the agonist and antagonist muscles of a human arm. The work also proposes a methodology for evaluating performance of interaction control schemes that is based on stiffness graphical representation through ellipses. The method replicates the experimental setup used in neuroscience to measure stiffness in human limbs. It is regarded as a powerful tool for evaluating robot behavior over space and time, since it allows both a visual representation of stiffness variation during motion and a quantitative measure of robot performance. It is shown how the method can be used to evaluate a control scheme and how it can provide indications to improve a control law. In this paper, an application to the standard compliance control in the joint space and the coactivation‐based compliance control is presented. © 2005 Wiley Periodicals, Inc.