gebhart/patrepeval huggingface dataset:
A quality framework for the role of invasive, non‐interventional cardiologists in the present‐day cardiac catheterization laboratory: A multidisciplinary SCAI/HFSA expert consensus statement (2018)

The present-day cardiac catheterization laboratory (CCL) is home to varied practitioners who perform both diagnostic, interventional, and complex invasive procedures. Invasive, non-interventional cardiologists are performing a significant proportion of the work as the CCL environment has evolved. This not only includes those who perform diagnostic-only cardiac catheterization but also heart failure specialists who may be involved in hemodynamic assessment and in mechanical circulatory support and pulmonary hypertension specialists and transplant cardiologists. As such, the training background of those who work in the CCL is varied. While most quality metrics in the CCL are directed towards evaluation of patients who undergo traditional interventional procedures, there has not been a focus upon providing these invasive, noninterventional cardiologists, hospital/CCL administrators, and CCL directors a platform for quality metrics. This document focuses on benchmarking quality for the invasive, noninterventional practice, providing this physician community with guidance towards a patient-centered approach to care, and offering tools to the invasive, noninterventionalists to help their professional growth. This consensus statement aims to establish a foundation upon which the invasive, noninterventional cardiologists can thrive in the CCL environment and work collaboratively with their interventional colleagues while ensuring that the highest quality of care is being delivered to all patients.
Editor-in-Chief’s Year-End Message (2019)

Dear Readers, Another fantastic year for TIM comes to an end, and I am delighted to share with you both the great achievements of 2019 and the exciting plans ahead. As always, let us start with the most important aspect, which is the quality of our journal.
A miniature DC-70 GHz SP4T switch in 0.13-&amp;#x00B5;m CMOS (2009)

This paper presents a miniature DC-70 GHz single-pole four-throw (SP4T) built in a low-cost 0.13-mum CMOS process. The switch is based on a series-shunt design with input and output matching circuits. Deep n-well (also called triple-well) CMOS transistors are used to minimize the substrate coupling. Also, deep trench isolation is used between the different ports to minimize the port-to-port coupling. The SP4T results in a measured insertion loss of less than 3.5 dB up to 67 GHz with an isolation of greater than 25 dB. The measured port-to-port coupling is less than 28 dB up to 67 GHz. The measured P1dB and IIP3 are independent of frequency and are 9-10 dBm and 20-21 dBm, respectively. The active chip area is 0.24times0.23 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . To our knowledge, this work represents the widest bandwidth SP4T switch in any CMOS technology to-date.
Tape casting of oxide-ceramic electrolyte layers for all-solid-state lithium batteries (2015)

All-solid-state lithium batteries (ASB) have better safety properties due to the incombustible solid electrolyte than commercial lithium ion batteries (LIB), which use flammable organic liquid as electrolyte. Their compatibility with using high voltage cathode materials enables a higher energy density. Oxide-ceramic lithium ion conductors such as Li7La3Zr2O12 (LLZ) [1] have a good total ion conductivity of about 10 4 S cm-1 at room temperature [2]. The stability of LLZ when contacting lithium metal and its wide electrochemical stability window (usable up to 8V vs. Li/Li+) would provide higher energy densities than common LIB. In combination with its advantage of inertness in oxygen atmosphere, which simplifies their handling during materials processing, it is one of the most promising candidates for all-solid-state battery application. LLZ was synthesized via solid state reaction and spray pyrolysis. The structural stability and LLZ’s total ion conductivity were improved by substitution of Al [2], Ta [3] and Y [4] into the LLZ structure. Ta substituted LLZ indicated the highest total ionic conductivity of about 10-3 S cm-1 and almost no dependence on its lithium concentration. After investigation of bulk electrolyte materials, an ASB prototype cell using bulk LLZ as solid electrolyte was fabricated at IEK-1 and proved to run an LED. To meet the technical requirements of real battery systems, large size LLZ functional layers need to be fabricated by different established technologies. To bridge from lab works to application, the investigated LLZ has been processed by tape casting and was used for sintering studies, in order to obtain highly dense solid electrolyte layers and also mixed electrode films for prospective all-solid-state lithium batteries.References:[1] Murugan et al., Angew. Chem. Int. Ed. 46 (2007) 7778.[2] Hubaud et al., J. Mater. Chem. A. 1 (2013) 8813. [3] Buschmann et al., Phys. Chem. Chem. Phys. 13 (2011) 19378.[4] Murugan et. al., Electrochem. Commun. 13 (2011) 1373.
Challenging the Classical Distinction Between Long-Term and Short-Term Memory: Reconsidering the Role of the Hippocampus (2011)

The hippocampus and surrounding medial temporal lobe structures have long been held to be critical for long-term declarative memory, but not for short-term or working memory. In fact, the notion that patients with selective and bilateral medial temporal lobe lesions have intact short-term memory has been a key argument to support the classical distinction between long- and short-term memory. However, recent behavioral, neuroimaging and electrophysiological data collected in humans have begun to challenge this classical distinction. Converging evidence now suggests that the ability to maintain the configural relationships of visual information in working memory for periods as short as a few seconds critically depends on the hippocampus. In functional terms, the hippocampus may be necessary for coordinating short-term maintenance when it relies on distributed cortical representations of objects, locations and their conjunctions. These findings indicate a need for modifying the current diagnostic work-up of patients with hippocampal lesions and the neuropsychological criteria for hippocampal dysfunction, which are currently centered upon the theory that hippocampal lesions will primarily affect long-term memory.
A29 NOVEL FECAL BIOMARKERS THAT PRECEDE CLINICAL DIAGNOSIS OF ULCERATIVE COLITIS (2021)

Abstract Background Altered gut microbiota composition and function has been associated with inflammatory bowel diseases (IBD) including ulcerative colitis (UC), but causality and mechanisms remain unknown. Most studies have examined patients with active or treated disease and little is known about microbial compositional or functional changes that occur before disease onset. Aims We studied a longitudinal cohort of subjects at risk for IBD to define the fecal microbial composition and function in subjects prior to UC onset (pre-UC) and at diagnosis (post-UC), and in matched at-risk subjects that remained healthy. Methods Fecal samples were collected from healthy individuals at-risk for IBD (pre-UC; n=13) and subjects were followed longitudinally until UC diagnosis (post-UC, n=9), at which point another fecal sample was collected. Fecal samples from a cohort of matched at-risk individuals that did not develop UC were used as healthy controls (n=48). We applied 16S rRNA gene sequencing, next generation shotgun sequencing, in vitro proteolytic assays and gnotobiotic colonizations to define the microbial composition and proteolytic function in fecal samples. Results The microbiota of post-UC subjects clustered separately from pre-UC and HC subjects, based on bray-curtis and unweighted UniFrac, had reduced alpha-diversity, and had reduced abundance of Aldercreutzia compared to pre-UC and HC. In vitro functional analysis revealed increased fecal proteolytic and elastase activity in pre-UC and post-UC samples compared to HC. Metagenomics identified pathways and gene families related to protein metabolism and proteases/peptides that were significantly different between HC and pre-UC samples, suggesting a bacterial component to the pre-UC proteolytic signature. Elastase activity inversely correlated with the relative abundance of Adlercreutzia, and other potentially beneficial taxa, and directly correlated with Bacteroides vulgatus, a known proteolytic taxon. High elastase activity was confirmed in Bacteroides isolates from fecal samples. Bacterial contribution and functional significance of the proteolytic signature was investigated in germ-free adults and litters born from dams colonized with HC, pre-UC or post-UC microbiota. Mice colonized with pre-UC microbiota at adulthood or neonatally developed higher fecal proteolytic activity and an inflammatory immune tone compared with HC colonized mice. Conclusions We have identified increased fecal proteolytic activity that precedes clinical diagnosis of UC and associates with gut microbiota changes. This may constitute a non-invasive biomarker of inflammation to monitor at-risk populations that can be targeted therapeutically with anti-proteases. Funding Agencies CAG, CCC, CIHR
Isosteric Heats of Adsorption on Carbon Predicted by Density Functional Theory (1998)

Isosteric heats of adsorption (qst) of propane and butane adsorbed on carbon were studied by numerical differentiation of nonlocal density functional theory (NDFT) isotherms. The qst values of both adsorbates in slit-shaped pores were a weak function of temperature, and decreased with increasing pore width. Using the calculated pore size distribution (PSD) of an activated carbon, it was further determined that the qst for both propane and butane decreased with increasing loading, consistent with a heterogeneous adsorbent. The NDFT results utilizing the PSD were also in fair agreement with those obtained from the classical approach using experimental isotherms fitted to a model and applied to the Clausius−Clapeyron-type equation; both models predicted qst of butane to be ∼10 kJ/mol higher than that of propane at the same loading. On a model homogeneous carbon, the qst of both adsorbates increased with reduced surface coverage up to ∼0.5, then they dropped rapidly. The reduced surface coverages corresponding to monolayer completion were 0.61 for propane and 0.65 for butane, in agreement with published experimental results.
Factors influencing adenoviral gene transfer (2001)

There is increasing interest in adeno-associated virus (AAV) vectors for a wide variety of gene therapy applications. AAV is a nonpathogenic human parvovirus that can mediate long-term transduction of a number of cell types without provoking a significant immune response. These properties make AAV especially attractive for use in gene therapy of rheumatoid arthritis (RA), a chronic inflammatory disease. To investigate the potential of AAV in gene therapy of arthritis, the ability of AAV to infect synovium in vitro and in vivo was tested. Three human RA synovial fibroblast cell lines and two murine (one DBA/1J and one DBA1JC3H F1) synovial fibroblast cell lines were used to test AAV transduction in vitro. The cell lines (2 10 5 cells) were infected with 10 4 particles/cell of a murine IL-10-encoding vector (AAV-mIL-10) alone or with the addition of a low titer (100 particles/cell) of an E1-, E3-deleted recombinant adenovirus to provide E4orf6 activity to enhance second-strand synthesis. The supernatants were harvested from the wells at various time points and assayed for mIL-10 expression by ELISA. Both human synovial cell lines infected with AAV alone demonstrated low-level transgene expression throughout the course of the study. However, by day 10, all human cultures coinfected with adenovirus showed a 16-to 56-fold increase in mIL-10 compared to cultures infected with AAV-mIL10 alone. By day 30, a 31-to 135-fold increase was observed. No such increase was observed in any of the mouse cell lines. To determine the AAV transduction efficiency for synovium in vivo, human RA synovial tissues obtained from patients undergoing joint-replacement surgery were implanted subcutaneously on the backs of NOD.CB17-Prkdc SCID mice. After allowing a 2-week period for engraftment, tissues were injected with 3.4 10 11 particles of AAV-luciferase alone or in combination with 1.0 10 11 particles of adenovirus. Two weeks following AAV administration, the tissues were homogenized and assayed for expression of luciferase. Only the tissues coinfected with adenovirus had luciferase levels above background. A similar experiment with AAV-LacZ demonstrated X-gal staining only of synovial tissues coinfected with adenovirus. These findings demonstrate a preferential ability of AAV to transduce human, compared to mouse, synovial tissue and suggest that second strand synthesis may be a limiting factor in gene transduction. Further studies to elucidate the mechanisms limiting gene transduction in human synovium may allow optimization of this vector for the treatment of arthritis.
ChemInform Abstract: Alkylidynetricobalt Nonacarbonyl Complexes as Hydroformylation Catalysts. (1984)

Abstract Die polymerisierbaren Alkylidintricobaltcluster (III), (Vc) und (VI) werden wie aufgezeigt nach bekannten Methoden dargestellt.
Towards Detection of Single Rare-Earth-Ions in a Nanophotonic Resonator (2015)

We report a scheme for detecting single rare-earth-ions coupled to an Yttrium Orthosilicate (YSO) nanophotonic resonator, which could enable precise optical addressing of individual ions as single qubits for quantum information applications.
Validated high-performance thin-layer chromatography method for the determination of nicotine in tobacco (<i>Nicotiana tabacum</i>L.) extracts (2012)

A new, simple, sensitive, selective, precise, and robust high-performance thin-layer chromatography (HPTLC) method was developed and validated for the determination of nicotine in tobacco extracts. The analysis of nicotine was performed on thin-layer chromatography (TLC) glass plates precoated with silica gel 60 F254 as stationary phase. Development was carried out in a horizontal chamber under sandwich configuration with the mobile phase ethyl acetate-methanol-ammonia 2.8% (v/v) (20:10:4, v/v/v) at room temperature (25 ± 2°C). A TLC scanner was used for spectrodensitometric scanning and analysis in the absorbance mode at 263 nm. The system was found to give compact spots for nicotine (RF value of 0.20 ± 0.02). The calibration plots showed good linear relationships with r2 = 0.9998 ± 0.0001 in the concentration range 90-900 ng/spot with respect to the peak area. According to the International Conference of Harmonization (ICH) guidelines, the TLC method was validated for precision, recovery, robustness, and ruggedness. The detection and quantification limits were determined. Statistical analysis of the data revealed that the method is reproducible and selective for the determination of nicotine content in tobacco extracts.
Structurally investigating a niche pathway for chemical reversal of proline hydroxylation in the pathogen <i>Clostridioides difficile</i> (2022)

The glycyl radical enzyme (GRE) family utilizes a glycyl radical cofactor, installed by AdoMet radical activating enzymes, to catalyze difficult chemical reactions in a variety of microbial metabolic pathways. Although GREs are widely encoded and expressed by bacteria found in the gut microbiome, these enzymes remain largely uncharacterized. Recently a new GRE, hydroxyproline dehydratase (HypD) was discovered to catalyze the dehydration of trans ‐4‐hydroxy‐L‐proline (4‐Hyp) to 1‐pyrroline‐5‐carboxylic acid. HypD is the second most prominent GRE in the human gut microbiome and is encoded by 360 bacterial genomes, including the commonly antibiotic‐resistant human pathogen C. difficile . HypD presents a pathway for bacteria to reverse 4‐Hyp post‐translational modifications, the most common post‐translational modification in animals, which was previously thought to be irreversible. Furthermore, the bacteria that encode HypD are known to use 4‐Hyp as an electron acceptor during amino acid fermentation, their primary method of generating adenosine triphosphate (ATP). However, the enzyme responsible for assimilating 4‐Hyp into this pathway has remained unknown until now. HypD could be the missing puzzle piece to understanding how these bacteria use the abundant metabolite 4‐Hyp in energy production, while also symbiotically providing humans with a method for recycling this common amino acid. In order to elucidate the mechanism for how HypD performs the dehydration of hydroxyproline, we aimed to characterize HypD from C. difficile , in the presence of its substrate. Here, we have solved a 2.05‐Å resolution structure for HypD by molecular replacement. Subsequently, a structure for HypD with its substrate 4‐Hyp bound in the active site was solved to 2.52‐Å resolution. These structures, accompanied by site‐directed mutagenesis studies and biochemical assays with deuterated substrate, have led us to identify key catalytic residues and have provided insight into the radical mechanism for 4‐Hyp dehydration.
Autonomous and Adaptive Agents that Gather Information (1996)

We have designed and implemented autonomous software agents. Our agents are programs that can move independently through a heterogeneous network of computers. They can sense the state of the network, monitor software conditions, and interact with other agents. The network-sensing tools allow our agents to adapt to the network configuration and to navigate under the control of reactive plans. In this paper we illustrate the intelligent and adaptive behavior of autonomous agents in distributed information-gathering tasks. 1 Introduction Modern information systems have data distributed over heterogeneous and unreliable networks. We wish to develop sophisticated methods for browsing, searching, and organizing distributed information systems. Traditional approaches to distributed information access co-locate the data and the computation needed to process it by bringing the data to the computation. We advocate a novel approach that brings the computation to the data in the form of transport...
Progress towards atmospheric isotope ratio carbon dioxide and nitrous oxide reference materials that meet the WMO-GAW data quality objectives for compatibility (2020)

&amp;lt;p&amp;gt;Widely available reference materials that are traceable and consistent with international stable isotope scales are necessary in order to create a robust and sustainable global measurement infrastructure for isotope ratio of CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt; and N&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt;O.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;We report on progress towards the production and certification of atmospheric amount fraction greenhouse gas reference materials with isotope ratios spanning the full atmospheric range. Reference materials are produced with a chosen delta value with uncertainties aiming to achieve the WMO GAW data quality objectives for extended compatibility of delta value of of &amp;amp;#8706;&amp;lt;sup&amp;gt;13&amp;lt;/sup&amp;gt;C-CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt; and &amp;amp;#8706;&amp;lt;sup&amp;gt;18&amp;lt;/sup&amp;gt;O-CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt; of 0.1&amp;amp;#8240; (northern hemisphere) and amount fraction of 0.2 &amp;amp;#181;molmol&amp;lt;sup&amp;gt;-1&amp;lt;/sup&amp;gt; for CO&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt; and 0.3 nmolmol&amp;lt;sup&amp;gt;-1&amp;lt;/sup&amp;gt; for N&amp;lt;sub&amp;gt;2&amp;lt;/sub&amp;gt;O at atmospheric amount fraction ranges.&amp;lt;/p&amp;gt;&amp;lt;p&amp;gt;To illustrate the work towards these challenging goals we present studies of sampling technique and isotope ratio stability with storage, pressure and cylinder passivation. The precision of blending and dilution of source gases is presented alongside studies of measurement instrument precision and drift. Contributing factors from matrix gases are also discussed.&amp;amp;#160;&amp;lt;/p&amp;gt;
Distributed Scheduling of Nonlinear Computational Loads (2003)

It is demonstrated that supra-linear (greater than linear) speedup is possible in processing distributed divisible computational loads where computation time is a nonlinear function of load size. This result is radically dierent from the traditional distributed processing of computational loads with linear processing complexity appearing in over 50 journal papers.
Dinucleotide repeat polymorphisms at the D4S126 and D4S114 loci (1993)

Journal Article Dinucleotide repeat polymorphisms at the D4S126 and D4S114 loci Get access Danilo A. Tagle, Danilo A. Tagle * 1Departments of Human Genetics, The University of Michigan Medical CenterAnn Arbor, Ml 48109, USA *To whom correspondence should be addressed Search for other works by this author on: Oxford Academic PubMed Google Scholar Kristina L. Blanchard-McQuate, Kristina L. Blanchard-McQuate 2Howard Hughes Medical InstituteAnn Arbor, Ml 48109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar John Valdes, John Valdes 1Departments of Human Genetics, The University of Michigan Medical CenterAnn Arbor, Ml 48109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Lucio Castilla, Lucio Castilla 3Departments of Biology, The University of Michigan Medical CenterAnn Arbor, Ml 48109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Francis S. Collins Francis S. Collins 1Departments of Human Genetics, The University of Michigan Medical CenterAnn Arbor, Ml 48109, USA4Departments of lnternal Medicine, The University of Michigan Medical CenterAnn Arbor, Ml 48109, USA2Howard Hughes Medical InstituteAnn Arbor, Ml 48109, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Human Molecular Genetics, Volume 2, Issue 7, July 1993, Page 1077, https://doi.org/10.1093/hmg/2.7.1077 Published: 01 July 1993
Variable structure systems approach to friction estimation and compensation (2002)

Compensating for friction is considered in the paper using the variable structure systems approach. First, variable structure-based observers are developed for friction estimation in mechanical systems with or without information of velocity. The estimates are then used for a model-based feedforward compensation for friction. For a non-model based approach, a robust sliding mode controller can also be used to cancel the influence of friction. Sigmoidal functions are used in lieu of signum functions to reduce chattering. Simulation results verify the validity of the proposed technique to compensate for friction of both static and dynamic models.
Expert opinion on the use of cladribine tablets in clinical practice (2020)

These expert recommendations provide up-to-date relevant guidance on the use of cladribine tablets in clinical practice.