gebhart/patrepeval huggingface dataset:
GENOMIC ANALYSIS OF FOOD-BORNE STAPHYLOCOCCUS AUREUSCC30 STRAINS IN THE RUSSIAN FEDERATION (2017)

Staphylococcus aureus clonal complex (СС) 30 are associated with hospital-acquired and community-associated invasive infections and may cause outbreaks of staphylococcal food-borne infections (SFI). In recent years, severe SFI outbreaks caused by S. aureus CC30 in cohorts not linked to high-risk groups have been detected in Russia.Aim: The aim of the study is to conduct a comparative genomic analysis of S. aureus strains B-7778 and B-7779 isolated during widespread SFI outbreak at the International Youth Forum Seliger in 2014, and S. aureus strains B-7738 and B-7739 isolated during widespread SFI outbreak among construction personnel in Saint Petersburg in 2013.Methods: Seliger-2014 S. aureus cultures were screened by PCR and sequence typing. S. aureus strains B-7778 and B-7779 were isolated from clinic material and from food handlers, respectively. Draft genome sequencing and phylogenetic analysis of S. aureus strains B-7778 and B-7779 were carried out. The production of enterotoxin A was determined by the enzyme immunoassay.Results: S. aureus strain B-7778 isolated from 38 patients and S. aureus strain B-7779 isolated from two food handlers at the Forum Seliger-2014 have identical nucleotide sequences, belong to spa-type t122 and sequence-type 30, and carry a set of toxin genes being responsible for SFI manifestations. The core-genome SNP typing has shown that S. aureus B-7738/ B-7739 (St. Petersburg, 2013) and S. aureus B-7778/ B-7779 (Seliger, 2014) belong to different clusters of S. aureus СС30 clade 3. S. aureus B-7778/ B-7779 not closely related with major clusters of S. aureus СС30. The production of enterotoxin A, SFI etiological factor, by S. aureus strains B-7738, B-7739, B-7778, and B-7779 has been confirmed.Conclusion: The genomic analysis of SFI-associated S. aureus strains isolated in Russia has been conducted for the first time. Two different genetic clones of S. aureus СС30 which are able to cause severe SFI outbreaks in cohorts not linked to high-risk groups have been identified and characterized. SNP typing of Seliger-2014 S. aureus genomes has revealed their genetic specificity among known strains of S. aureus CC30. Identified genome sequences of SFI-associated strains will be used for further studies S. aureus clones circulating through the food chain in Russia.
CD4-helper-independent antiviral function of CD8-positive memory T lymphocytes derived from latently infected donors (1988)

The ability of memory T lymphocytes derived from latently infected mice to control murine cytomegalovirus disease in the immunocompromised host was studied by adoptive transfer experiments. At a stage of pathogenesis when virus had already colonized target tissues, a therapeutic antiviral function could be ascribed to the CD8+ subset. This in vivo function was not restricted to sites in which intravenously infused lymphocytes usually are trapped or home in, such as the lungs or the spleen, respectively, but was also evident in the adrenal glands, a site to which antiviral effector cells have to specifically migrate. Specific infiltration of adrenal gland cortical tissue by donor-derived CD8+ memory T lymphocytes was demonstrated. CD4+ memory T lymphocytes had no antiviral effect by themselves and also were not required for the function of the CD8+ effector cells in this short-term immunotherapy model. These findings should help settle the debate about which subset of T lymphocytes comprises the effector cells that can directly control cytomegalovirus infection in the murine model system.
A highly miniaturized, battery operated, commandable, digital wireless camera (2002)

This paper discusses the design, development, testing, and demonstration of a highly miniaturized battery operated, digital wireless camera. The miniature wireless camera receives commands transmitted from a remote base station requesting it to take one or more frames of data, and broadcasts the digital image data to the base station receiver for display. The camera uses a complementary metal-oxide-semiconductor (CMOS) active pixel image sensor (APS) that achieves noise performance comparable to a charge-coupled device (CCD) with orders of magnitude better power consumption performance. The image sensor is integrated with a wireless communications transceiver, antennas and batteries into a stand alone miniature package. The results of a three year development effort are described.
A new self-checking sum-bit duplicated carry-select adder (2004)

In this paper the first code-disjoint totally self-checking carry-select adder is proposed. The adder blocks are fast ripple adders with a single NAND-gate delay for carry-propagation per cell. In every adder block both the sum-bits and the corresponding inverted sum-bits are simultaneously implemented. The parity of the input operands is checked against the XOR-sum of the propagate signals. For 64 bits area and maximal delay are determined by the SYNOPSYS CAD tool of the EUROCHIP project. Compared to a 64 bit carry-select adder without error detection the delay of the most significant sum-bit does not increase. The area is 170% of a 64 bit carry-select adder (without error detection and not code-disjoint).
Synthesis and cationic photopolymerization of monomers based on nopol (1999)

Starting with nopol [(R)-(−)-2-(2′-hydroxyethyl)-6,6-dimethyl-8-oxatricyclo[3.1.1.12,3]octane, I] as a substrate, two new, interesting monomers, allyl nopol ether epoxide III and nopol 1-propenyl ether epoxide IV, were prepared. The photoinitiated cationic polymerizations of these two monomers as well as several other model compounds were studied using real-time infrared spectroscopy. Surprisingly, the rates of epoxide ring-opening polymerization of both monomers were enhanced as compared to those of the model compounds. Two different mechanisms which involve the free radical induced decomposition of the diaryliodonium salt photoinitiator were proposed to explain the rate acceleration effects. © 1999 John Wiley & Sons, Inc. J Polym Sci A: Polym Chem 37: 1199–1209, 1999
Swiss Science Concentrates (2019)

The use of molecular Cr(iii)-based coordination complexes to construct cheap emissive chiral materials is of great interest for many applications. The authors report the chiral resolution of the kinetically inert complex [Cr(dqp) 2 ] 3+ , formed with two chelating 2,6-di(quinolin-8-yl)pyridine (dqp) ligands, by cation-exchange chromatography and salt-metathesis. The dissymmetry factors measured by circularly polarized luminescence, which shows two emission bands within the NIR region due to the metalcentered spin-flip, were exceptionally high and comparable to values reported for lanthanides. Moreover, an extremely longlived room temperature phosphorescence (1.2 ms) was observed in water, together with a high quantum yield (5.2%).
Nuclear androgen receptor staining in bone metastases is related to a poor outcome in prostate cancer patients (2010)

Androgen receptors (ARs) are probably of importance during all phases of prostate cancer (PC) growth, but their role in bone metastases is largely unexplored. Bone metastases were therefore collected from hormone-naive (n=11), short-term castrated (n=7) and castration-resistant PC (CRPC, n=44) patients by biopsy (n=4) or at surgery to alleviate symptoms from metastases complications (metastasis surgery, n=58), and immunostained for nuclear ARs, Ki67, active caspase-3, prostate-specific antigen (PSA) and chromogranin A, and results were related to serum PSA, treatments and outcome. Nuclear AR immunostaining was decreased and apoptosis was increased, but cell proliferation remained largely unaffected in metastases within a few days after surgical castration. In CRPC patients, nuclear AR staining of metastases was increased when compared to short-term castrated patients. The nuclear AR staining score was related to tumour cell proliferation, but it was not associated with other downstream effects of AR activation such as apoptosis and PSA staining, and it was only marginally related to the presence of neuroendocrine tumour cells. Serum PSA at metastasis surgery, although related to outcome, was not associated with AR staining, markers of metastasis growth or PSA staining in metastases. High nuclear AR immunostaining was associated with a particularly poor prognosis after metastasis surgery in CRPC patients, suggesting that such men may benefit from the potent AR blockers now tested in clinical trials.
Comprehensive characterization of cellular immune responses following Ebola virus infection (2016)

The West African Ebola virus disease (EVD) outbreak was the largest EVD outbreak in history. However, data on lymphocyte dynamics and the antigen specificity of T cells in Ebola survivors are scarce, and our understanding of EVD pathophysiology is limited. A case of EVD survival in which the patient cleared Ebola virus (EBOV) infection without experimental drugs allowed for the detailed examination of lymphocyte dynamics. We demonstrate the persistence of T-cell activation well beyond viral clearance and detect EBOV-specific T cells. Our study provides significant insights into lymphocyte specificity during the recovery phase of EVD and may inform novel strategies to treat EVD.
Polyhedral Non-ionic Surfactant Vesicles (1997)

Large polyhedral (2-10 microns) non-ionic surfactant vesicles (niosomes) formed from mixtures of a hexadecyl diglycerol ether (C16G2), a cholesteryl poly-24-oxyethylene ether (solulan C24) and a low level of cholesterol are being investigated as slow-release systems for ophthalmic, subcutaneous or intramuscular administration. The phase-diagram of this three-component system has been constructed and these polyhedral vesicles are found to be in the gel (L beta) phase. Confocal laser-scanning microscopy was used to confirm the complex morphology of these vesicles. The thermo-responsive nature of release of entrapped carboxyfluorescein and nicotinamide adenine dinucleotide has been studied; release is increased with increase in temperature (37 degrees C) even though the polyhedral vesicles still maintain their polyhedral shape at this temperature. The results indicate that the thermo-responsive features of the niosomes are a result of reversible changes in bi-layer permeability caused by temperature-mediated alteration in the membrane-packing characteristics of the polyethoxylated cholesterol ether.
When private keys are public (2009)

We report on the aftermath of the discovery of a severe vulnerability in the Debian Linux version of OpenSSL. Systems affected by the bug generated predictable random numbers, most importantly public/private keypairs. To study user response to this vulnerability, we collected a novel dataset of daily remote scans of over 50,000 SSL/TLS-enabled Web servers, of which 751 displayed vulnerable certificates. We report three primary results. First, as expected from previous work, we find an extremely slow rate of fixing, with 30% of the hosts vulnerable when we began our survey on day 4 after disclosure still vulnerable almost six months later. However, unlike conventional vulnerabilities, which typically show a short, fast fixing phase, we observe a much flatter curve with fixing extending six months after the announcement. Second, we identify some predictive factors for the rate of upgrading. Third, we find that certificate authorities continued to issue certificates to servers with weak keys long after the vulnerability was disclosed.
Investigation of strengthening mechanism in extrusion of Mg96Zn2Y2 alloy ingot and chips (2007)

In order to make the effect of processing clear, Mg96Zn2Y2 alloy ingot and machined chips were extruded at various extrusion conditions. Tensile yield strength of extruded bar from ingot and extrusion force were increased with decreasing extrusion temperature. Tensile yield strength and extrusion force was proportional to hardness of ingot that is measured at extrusion temperature. Increased hot hardness resulted in improved strength with increasing of the degree of work hardening and extrusion force. Improvement of the degree of work hardens was observed as crystal orientation by XRD. Meanwhile, strain hardening of machined chips plays a major role of strengthening at extruded bar from chips. Static recrystallization of chips at preheating causes randomization of crystal orientation and higher elongation of extruded bar from chips. Difference in recrystallization behavior between extrusion of ingot and chips, dynamic recrystallization at ingot extrusion and static recrystallization at chips extrusion, was due to difference of strength mechanism of extruded bar from ingot and chips.
Prise en charge de l’hémophilie en salle d’urgence (2012)

L’hémophilie est une maladie génétique rare due à un déficit en facteur VIII ou IX de la coagulation sanguine. Cette affection est responsable d’hémorragies spontanées ou provoquées en fonction de la sévérité du déficit en facteur. L’admission en salle d’urgence d’un patient hémophile est peu fréquente en raison de la rareté de la maladie, des progrès thérapeutiques et surtout depuis la promotion de l’autotraitement des patients au domicile. Au cours d’une période de douze mois, seules 0,05 % des admissions en salle d’urgence dans un hôpital universitaire bruxellois ont concerné des patients hémophiles, tous motifs confondus. L’urgentiste est par conséquent exceptionnellement confronté à un patient hémophile à l’occasion d’un accident hémorragique ou de tout autre problème médical aigu dont la prise en charge est à adapter en fonction de l’hémophilie. L’urgentiste doit également suspecter cette maladie hémorragique rare et méconnue lorsque qu’un patient sans hémophilie connue se présente en salle d’urgence avec des manifestations hémorragiques. Cet article résume les principales données physiopathologiques de l’hémophilie, les options et les recommandations thérapeutiques en salle d’urgence. Il a pour but de rappeler à l’urgentiste les notions indispensables permettant une prise en charge appropriée des patients hémophiles dès l’admission en salle d’urgence.
Structural and Physical Studies on a New Class of Low-Dimensional Conducting Material: Feoc1 Intercalated With TTF and Related Molecules (1985)

Abstract Intercalation of TTF (tetrathiafulvalene), TTN (tetrathianaphthalene), and related organosulfur electron donors into Fe0C1 results in a significant expansion along the inter layer (b) axis, with the organosulfur molecules apparently inclined with respect to this axis. Electronic spectra suggest that the intercalates are semiconductors with band gaps of ca. 0.4 – 0.5 eV, consistent with previous conductivity data. Elastic neutron diffraction data (10K) show that magnetic ordering of the Fe0C1 host is abolished upon intercalation.
Fibroblasts Isolated from Human Middle Turbinate Mucosa Cause Neural Progenitor Cells to Differentiate into Glial Lineage Cells (2013)

Transplantation of olfactory ensheathing cells (OECs) is a potential therapy for repair of spinal cord injury (SCI). Autologous transplantation of OECs has been reported in clinical trials. However, it is still controversial whether purified OECs or olfactory mucosa containing OECs, fibroblasts and other cells should be used for transplantation. OECs and fibroblasts were isolated from olfactory mucosa of the middle turbinate from seven patients. The percentage of OECs with p75(NTR+) and GFAP(+) ranged from 9.2% to 73.2%. Fibroblasts were purified and co-cultured with normal human neural progenitors (NHNPs). Based on immunocytochemical labeling, NHNPs were induced into glial lineage cells when they were co-cultured with the mucosal fibroblasts. These results demonstrate that OECs can be isolated from the mucosa of the middle turbinate bone as well as from the dorsal nasal septum and superior turbinates, which are the typical sites for harvesting OECs. Transplantation of olfactory mucosa containing fibroblasts into the central nervous system (CNS) needs to be further investigated before translation to clinical application.
ChemInform Abstract: Solid Phase Synthesis of [4‐Allo‐L‐threonine]‐Oxytocin. (1985)

Abstract Zur Untersuchung der biologischen Aktivität wird die Titelverbindung (III) nach der Festphasenmethode ausgehend vom Baustein (II) synthetisiert.
Effects of pH on techno-functionality and interfacial activity of potato protein extract (PPE) (2021)

The discharged wastewater from potato starch factories known as potato fruit juice (PFJ) contains 1-1.5% protein with potential techno-functionalities if recovered by non-destructive techniques. In this study, the intact potato protein extract (PPE) in aqueous solution (0.5% w/v) at different pH values (2, 4, 6, 8 and 10) was characterized with respect to solubility, emulsifying activity (EAI) and stability (ESI), droplet size, zeta potential and interfacial activity of stabilized interface. In a protein solubility graph, a valley shape was observed indicating the lowest solubility around pH 6, while the highest solubility was recorded at pH 2 and pH 8 as 53.4% and 42.0%, respectively. A pH-dependent trend was observed as both EAI and ESI were increased by shifting the pH from acidic region to the alkaline with highest values at pH 10. Apparently, the negatively charged protein at the alkaline region have higher emulsifying activity compared to the positively charged protein at acidic pH. Similarly, zeta potential data was dominated by the applied pH, i.e., a remarkable shift was recorded from pH 2 (-6.1), toward pH 8 (-30.3) and 10 (-31.5), corresponding to the droplet size (D3,2) of 2810 nm, 1013 nm and 947 nm, respectively. In terms of interfacial activity, the aqueous PPE solution actively reduced the interfacial tension (IFT) of stabilized interface in water-in-oil system at different pH values. However, apart from a stronger and much faster decrease of the IFT at the alkaline region, the formed droplet detached from the needle after nearly two min and less than one min at pH 8 and 10, respectively. This phenomenon can possibly be attributed to the synergistic effect of high protein concentration of aqueous phase in our study and pH-dependency of interfacial activity of PPE with very high mobility and flexibility at alkaline pH, yet to be clarified.
Mild Cognitive Impairment Subtypes and Vascular Dementia in Community‐Dwelling Elderly People: A 3‐Year Follow‐Up Study (2006)

All subjects who converted to subcortical VaD had been classified with mcd-MCI, suggesting that mcd-MCI might be an early stage of subcortical VaD.
On the Implementation of a Process Control System on a CAN Network: Linking the Process Control Parameters to the Network Parameters (2006)

Today communication networks are more and more used to implement distributed applications concerned by closed loop process controls. These applications require a timeliness service in order to guarantee performances (stability, ...). The goal of this paper is, by considering a closed loop process control application with an open loop transfer function of the type G(s)=K/s(1+/spl tau/s) (both no position error and the control of the speed error), to discuss its implementation on the network CAN (which can be either dedicated or shared) i.e. to link, accounting for the desired performances for the control application (phase margin, overtaking, rise time), the parameters associated to the process control (K, /spl tau/) and to the network (frame duration, priorities, buffering).
Challenges Botswana’s Mobile Application Developers Encounter: Funding, Commercial and Technical Support (2018)

Smart phone usage in Sub-Saharan Africa is expected to constitute&#13;\nmore than half of all mobile connections by 2020. Therefore, it can be expected&#13;\nthat mobile applications will change the way business is conducted and that&#13;\nmobile applications to address community needs would be developed by growing&#13;\na mobile based entrepreneurship ecosystem. Departing from the literature on&#13;\nmobile-based entrepreneurship ecosystems and specifically the research on Kenya,&#13;\nthis study investigates the case of Botswana. We focus on three of the most&#13;\npressing challenges, within Botswana’s mobile application ecosystem, namely the&#13;\nstate of funding, commercial and technical support. This interpretive research&#13;\nstudy comprises a descriptive research design conducted with mobile application&#13;\ndevelopers in Gaborone, Botswana to gather information concerning the current&#13;\nchallenges faced. As part of a larger study, the paper provides an overview of&#13;\nBotswana’s mobile application industry from a developer’s perspective and&#13;\nrecommendations for improving the state of funding, commercial and technical&#13;\nsupport for mobile application development. Furthermore, the research contributes&#13;\nto a better understanding of the mobile-based entrepreneurship ecosystems in the&#13;\nregion of Southern Africa.
Treatment of chronic GvHD with mesenchymal stromal cells induces durable responses: A phase II study (2020)

Steroid-refractory chronic graft-vs-host disease (cGvHD) contributes to morbidity after allogeneic hematopoietic stem cell transplantation. Here, we report on 11 patients with severe, refractory cGvHD treated with repeated infusions of allogeneic bone marrow-derived mesenchymal stromal cells (MSC) over a 6- to 12-month period. Six patients responded to MSC treatment following National Institutes of Health response criteria, accompanied by improvement in GvHD-related symptoms and quality of life. This response was durable, with systemic immunosuppressive therapy withdrawn from two responders, and a further two free from steroids and tapering calcineurin inhibitors. All responders displayed a distinct immune phenotype characterized by higher levels of naïve T cells and B cells before treatment compared with the nonresponders, and a significantly higher fraction of CD31+ naïve CD4+ T cells. MSC treatment was associated with significant increases in naïve T cells, B cells, and Tregs 7 days after each infusion. Skin biopsies showed resolution of epidermal pathology. CXCL9 and CXCL10 showed differential responses in responder and nonresponder patients. Our data support the use of MSC infusions as treatment for steroid-refractory cGvHD with durable responses. We propose CXCL9 and CXCL10 as early biomarkers for responsiveness to MSC treatment. Our results highlight the importance of the MSC recipient immune phenotype in promoting treatment response. This trial was registered at www.ClinicalTrials.gov as #NCT01522716.