gebhart/patrepeval huggingface dataset:
Data from FS118, a Bispecific Antibody Targeting LAG-3 and PD-L1, Enhances T-Cell Activation Resulting in Potent Antitumor Activity (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;Although programmed death-ligand 1 (PD-L1) antibody–based therapy has improved the outcome of patients with cancer, acquired resistance to these treatments limits their clinical efficacy. FS118 is a novel bispecific, tetravalent antibody (mAb&lt;sup&gt;2&lt;/sup&gt;) against human lymphocyte activation gene-3 (LAG-3) and PD-L1 with the potential to reinvigorate exhausted immune cells and overcome resistance mechanisms to PD-L1 blockade. Here, using FS118 and a murine surrogate, we characterized the activity and report a novel mechanism of action of this bispecific antibody.&lt;/p&gt;Experimental Design:&lt;p&gt;This study characterizes the binding activity and immune function of FS118 in cell lines and human peripheral blood mononuclear cells and further investigates its antitumor activity and mechanism of action using a surrogate murine bispecific antibody (mLAG-3/PD-L1 mAb&lt;sup&gt;2&lt;/sup&gt;).&lt;/p&gt;Results:&lt;p&gt;FS118 demonstrated simultaneous binding to LAG-3 and PD-L1 with high affinity and comparable or better activity than the combination of the single component parts of the mAb&lt;sup&gt;2&lt;/sup&gt; in blocking LAG-3- and PD-L1–mediated immune suppression and enhancing T-cell activity. In syngeneic tumor mouse models, mLAG-3/PD-L1 mAb&lt;sup&gt;2&lt;/sup&gt; significantly suppressed tumor growth. Mechanistic studies revealed decreased LAG-3 expression on T cells following treatment with the mouse surrogate mLAG-3/PD-L1 mAb&lt;sup&gt;2&lt;/sup&gt;, whereas LAG-3 expression increased upon treatment with the combination of mAbs targeting LAG-3 and PD-L1. Moreover, following binding of mLAG-3/PD-L1 mAb&lt;sup&gt;2&lt;/sup&gt; to target-expressing cells, mouse LAG-3 is rapidly shed into the blood.&lt;/p&gt;Conclusions:&lt;p&gt;This study demonstrates a novel benefit of the bispecific approach over a combination of mAbs and supports the further development of FS118 for the treatment of patients with cancer.&lt;/p&gt;&lt;/div&gt;
Transient Cerebral Ischemia Masquerading as Paroxysmal Dyskinesia (1990)

Hemiballism and hemichorea are recognized manifestations of cerebral infarction. Paroxysmal dyskinesias are less well recognized symptoms of transient cerebral ischemia. We describe a 41-year-old man with distal internal carotid artery occlusion and poor intracranial collaterization who developed repetitive stereotyped involuntary arm movements and subsequent cerebral infarction. This peculiar manifestation of transient cerebral ischemia may indicate poor intracranial collateralization with reliance upon leptomeningeal collaterals. Earlier recognition may help avert cerebral infarction.
Effect of HCl Acid and Brines on Water-Swelling Packers (2010)

Summary Achieving successful zonal isolation during well completion is critical to minimize early water production. Currently, cementing is the only method used in Saudi fields to provide zonal isolation. However, in horizontal sections, cementing becomes a challenge and excessive water production can occur because of channeling. Another method for zonal isolation is to use a rubber elastomer bonded onto a base pipe. The rubber swells in water and provides a seal between the base pipe and the open hole. This paper will outline the step-by-step qualification testing that was carried out in Saudi Aramco facilities in an attempt to improve zonal isolation in horizontal and multilaterals wells. In this study, we present laboratory evaluation of elastomers at 190°F using brines of different ionic strengths and pH values. The evaluation involved examining the effect of salinity and pH on elastomer swelling rate. Also, the study investigated the effect of 15 wt% hydrochloric acid (HCl) on swollen elastomers and whether the exposure to water after acid would restore their sizes. To the best of the authors' knowledge, no previous work has been performed to examine the impact of these factors on the swollen packers. The elastomer bonded onto pipes was tested in autoclaves. The pressure drop across the pipes was measured as a function of time. The influences of pH and divalent cations on water-swelling packers were investigated using elastomer samples. Swelling was related to fluid characteristics. Some water-swelling packers withstood pressures up to 5,000 psi at 190°F after placing the elastomers in brines with salinities up to 200,000 mg/L. However, the swollen elastomers shrank in 15 wt% HCl. A calcium chloride (CaCl2) completion fluid, a common fluid used in Saudi Aramco fields, at 72 lb/ft3 (pcf) failed to swell the elastomers. Re-exposure of shrunken coupons to water did not restore their initial swollen volume before acid soaking. This paper discusses the advantages and limitations of water-swelling elastomers and gives recommendations for successful field applications.
Measurement of the inclusive<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msub><mml:mi>ν</mml:mi><mml:mi>μ</mml:mi></mml:msub></mml:math>charged current cross section on iron and hydrocarbon in the T2K on-axis neutrino beam (2014)

We report a measurement of the inclusive charged current cross sections on iron and hydrocarbon in the Tokai-to-Kamioka (T2K) on-axis neutrino beam. The measured inclusive charged current cross sections on iron and hydrocarbon averaged over the T2K on-axis flux with a mean neutrino energy of 1.51 GeV are 1.444 AE 0.002stat 0.189 -0.157 syst 10 -38 cm 2 =nucleon and 1.379 AE 0.009stat 0.178 -0.147 syst 10 -38 cm 2 = nucleon, respectively, and their cross-section ratio is 1.047 AE 0.007stat AE 0.035syst. These results agree well with the predictions of the neutrino interaction model, and thus we checked the correct treatment of the nuclear effect for
The effect of carbon black and colloidal silica fillers on interfacial adhesion at polystyrene interfaces (2004)

We have shown that the addition of small amounts of carbon black can drastically reduce the interfacial fracture toughness between polymers. This is interpreted as being due to strong interactions between the filler particles and the polymer chains which hinder interfacial adhesion. The effect is less severe when graphitic carbon black particles are used. The fracture toughness was found to increase with time as t 1 / 2, regardless of filler concentration, indicating that interface formation was diffusion limited. A distinct minimum with filler concentration in the fracture toughness of interfaces annealed for times longer than 5 min was found. This feature could be explained as a balance between the increase in modulus and the decrease in polymer chain dynamics as a function of carbon black concentration. The addition of colloidal silica, where the surface interactions are screened, was found to reinforce the interface, as predicted by the Guth–Gold relationship. Mixing small quantities (<2%) of inert fillers with interfacially active ones restored the fracture toughness. This observation has practical importance since one can now obtain optimum adhesion without compromising the mechanical integrity provided by the reactive filler.
mlpack 4: a fast, header-only C++ machine learninglibrary (2023)

For over 15 years, the mlpack machine learning library has served as a “swiss army knife’’ for C++-based machine learning (Curtin et al., 2013). Its efficient implementations of common and cutting-edge machine learning algorithms have been used in a wide variety of scientific and industrial applications. This paper overviews mlpack 4, a significant upgrade over its predecessor (Curtin et al., 2018). The library has been significantly refactored and redesigned to facilitate an easier prototyping-to-deployment pipeline, including bindings to other languages (Python, Julia, R, Go, and the command line) that allow prototyping to be seamlessly performed in environments other than C++.
An overview of mineral-organic interactions related to oil sands processing (2013)

NRC publication: Yes
Abstract 1986: Tumor suppressor PDCD4 inhibits NFκB dependent transcription in human glioblastoma cells by direct interaction with p65. (2013)

Abstract PDCD4 was first described as a protein induced by apoptotic stimuli that acts as a tumor suppressor. PDCD4 plays an important role in regulating translation and transcription. Our previous research showed that overexpression of PDCD4 leads to decreased anchorage independent growth in glioblastoma-derived cell lines as well as decreased tumor growth in a glioblastoma xenograft model. Moreover, PDCD4 positively influences tumor necrosis factor-induced activation of the transcription factor NF-κB in inflammatory cells. However, the effect of PDCD4 on NF-κB transcriptional activity in cancer cells is still unknown. NF-κB acts as an oncogenic driver in many cancer sites. We studied the effect of PDCD4 on NF-κB-dependent transcriptional activity in malignant human glioblastoma cell lines by stably overexpressing PDCD4 in GBM U251 and LN229 cells. Stable Pdcd4 expression inhibits NF-κB transcriptional activation measured by a luciferase reporter in U251 and LN229 cells. The molecular mechanism by which PDCD4 inhibits NF-κB transcriptional activation does not involve inhibited expression of NF-κB p65 or p50 proteins. PDCD4 overexpression does not inhibit pathways upstream of NF-κB including the activation of IKKalpha and IKKbeta kinases. In addition, PDCD4 does not inhibit phosphorylation or degradation of IκBα, events needed for nuclear transport of p65 and p50. Overexpression of PDCD4 does, however, inhibit translocation of p65 but not p50 to the nucleus. Pdcd4 protein interacts directly with p65 protein as shown by co-immunoprecipitation and confocal imaging. These results suggest that PDCD4 can significantly inhibit NF-κB activity in glioblastoma cells by a mechanism that involves direct protein-protein interaction rather than the expected mRNA-selective translational inhibition. These findings may provide novel opportunities for NF-κB targeted interventions to prevent or treat cancer. Citation Format: Soon-Kyung Hwang, Matthew R. Young, Nancy H. Colburn. Tumor suppressor PDCD4 inhibits NFκB dependent transcription in human glioblastoma cells by direct interaction with p65. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 1986. doi:10.1158/1538-7445.AM2013-1986
Normal and cancer cell metabolism: lymphocytes and lymphoma (2012)

Recent studies of normal and neoplastic lymphocytes have revealed overlapping metabolic rewiring in activated T cells and Myc-transformed lymphocytes. Myc expression is attenuated in normal lymphocytes that return to the basal state, but Notch-activated or Myc-transformed lymphocytes persistently express Myc, which activates genes involved in glucose and glutamine metabolism. Although this difference could provide a therapeutic window for the treatment of cancers, the overlapping metabolic profiles suggest a potential for immunosuppression by metabolic inhibitors.
Restoration of Thoracic Kyphosis in Adolescent Idiopathic Scoliosis Over a Twenty-year Period: Are We Getting Better? (2020)

3.
Mechanism of Immune System Activation by (1,4)-α-D-glucan Isolated from Tinospora cordifolia in Macrophages. (2006)

Abstract We have characterized and reported the immunostimulating properties of a novel polysaccharide - (1,4)-α-D-glucan (RR1)- isolated from the medicinal plant Tinospora cordifolia [23]. This novel glucan is water soluble and having (1, 4)-α-D-glycosidic linkages in the main chain and (1, 6)-α-D-glycosidic linked side chains at an interval of 6, 7 glucose units. The signaling mechanism of the novel (1,4)-a-D-glucan (RR1) was investigated in macrophages to evaluate its immunostimulating properties. When RAW264.7 macrophages were incubated with RR1 at 4°C, the novel glucan inhibited the phagocytosis of unopsonized zymosan A bioparticles in a dose-dependent manner. RR1 also inhibited the binding and internalization of opsonized zymosan A bioparticles, although at a lower level than laminarin. Incubation of macrophages with anti-CD11b mAb followed by RR1 failed to show any inhibitory effect on RR1-induced TNF-α synthesis confirming that complement receptor 3 (CR3) is not involved in the opsonic binding and internalization of RR1 in macrophages unlike zymosan A. The anti-CD11b mAb has significant inhibitory effect on the zymosan A-induced tumor necrosis factor (TNF)-α synthesis. RR1 induced TNF-α synthesis in macrophages in a dose-dependent manner which can be completely inhibited by the NF-κB inhibitor caffeic acid phenethyl ester (CAPE) or curcumin. RR1 activated NF-κB in a time- and dose-dependent manner and this modulation of nuclear NF-κB activity is associated with the degradation of I-κB a thus facilitating the translocation of NF-κB into the nucleus. RR1-induced NF-κB activity peaks at 8 h of RR1 stimulation while I-κB a degradation occurred within 1 h of stimulation. RR1-induced NF-κB activation occurred through TLR6 signaling as evidenced by the synthesis of IL-8 in TLR6-transfected HEK293 cells. These results show that the novel (1,4)-α-D glucan from Tinospora cordifolia activates the immune system through the activation of macrophages that occurs through TLR6 signaling, NF-κB translocation and cytokine production. (Supported by Miami Children’s Hospital Foundation research funds).
Biofidelity assessment of the 6-year-old ATDs in lateral impact (2015)

All 3 ATDs are more biofidelic in the thorax and abdomen than the shoulder and pelvis, with the pelvis being the least biofidelic of all 4 tested body regions. None of the 3 tested 6-year-old ATDs had an overall ranking of 2.0 or less, based on the BRS ranking. Therefore, it is expected that none of the 3 ATDs would mechanically respond like a postmortem human subject (PMHS) in a lateral impact crash test based on this ranking system. With respect to the ISO biofidelity rating, the HIII dummy would be considered unsuitable and the Q-series dummies would be considered marginal for assessing side impact occupant protection.
Liquid Crystal Anamorphic Lens (2005)

A liquid crystal (LC) anamorphic lens is realized using an LC cell with a transparent electrode and a divided electrode with a hole in the center. By applying appropriate potentials on the divided electrode, the LC cell behaves like an optical lens with astigmatic properties. An incident plane lightwave experiences a nearly elliptical profile of phase retardation. The astigmatism is also electrically controllable.
Supplementary Figure 1 from Copper Chelation Enhances Antitumor Efficacy and Systemic Delivery of Oncolytic HSV (2023)

&lt;p&gt;PDF file, 46K, Quantification of color coded Ktrans and ve parametric images following DCE-MRI.&lt;/p&gt;
N-Dealkylation of pyrazoles using pyridine hydrochloride (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTN-Dealkylation of pyrazoles using pyridine hydrochlorideDonald E. Butler and Horace A. DeWaldCite this: J. Org. Chem. 1975, 40, 9, 1353–1355Publication Date (Print):May 1, 1975Publication History Published online1 May 2002Published inissue 1 May 1975https://pubs.acs.org/doi/10.1021/jo00897a041https://doi.org/10.1021/jo00897a041research-articleACS PublicationsRequest reuse permissionsArticle Views691Altmetric-Citations12LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
<i>TP53</i> mutation does not confer a poor outcome in adult patients with acute lymphoblastic leukemia who are treated with frontline hyper‐CVAD‐based regimens (2017)

Hyper-CVAD-based regimens appear to negate the poor prognostic impact of TP53 mutations in patients with adult B-cell immunophenotype ALL. Cancer 2017;123:3717-24. © 2017 American Cancer Society.
Heat Transfer Model of Hyporthermic Intracarotid Infusion of Cold Saline for Stroke Therapy (2006)

A 3-dimensional hemispheric computational brain model is developed to simulate infusion of cold saline in the carotid arteries in terms of brain cooling for stroke therapy. The model is based on the Pennes bioheat equation, with four tissue layers: white matter, gray matter, skull, and scalp. The stroke lesion is simulated by reducing blood flow to a selected volume of the brain by a factor of one-third, and brain metabolism by 50%. A stroke penumbra was also generated surrounding the core lesion (blood volume reduction 25%, metabolism reduction 20%). The finite difference method was employed to solve the system of partial differential equations. This model demonstrated a reduction in brain temperature, at the stroke lesion, to 32degC in less than 10 minutes
Repertoire of Epitopes Recognized by Serum IgG from Humans Vaccinated with Herpes Simplex Virus 2 Glycoprotein D (2014)

The results of a clinical trial of a subunit vaccine against genital herpes were recently reported (R. B. Belshe, P. A. Leone, D. I. Bernstein, A. Wald, M. J. Levin, J. T. Stapleton, I. Gorfinkel, R. L. Morrow, M. G. Ewell, A. Stokes-Riner, G. Dubin, T. C. Heineman, J. M. Schulte, C. D. Deal, N. Engl. J. Med. 366: 34-43, 2012, doi:10.1056/NEJMoa1103151). The vaccine consisted of a soluble form of herpes simplex virus 2 (HSV-2) glycoprotein D (gD2) with adjuvant. The goal of the current study was to examine the composition of the humoral response to gD2 within a selected subset of vaccinated individuals. Serum samples from 30 vaccine recipients were selected based upon relative enzyme-linked immunosorbent assay (ELISA) titers against gD2; 10 samples had high titers, 10 had medium titers, and the remaining 10 had low ELISA titers. We employed a novel, biosensor-based monoclonal antibody (MAb)-blocking assay to determine whether gD2 vaccination elicited IgG responses against epitopes overlapping those of well-characterized MAbs. Importantly, IgGs from the majority of gD2-immunized subjects competed for gD binding with four antigenically distinct virus-neutralizing MAbs (MC2, MC5, MC23, and DL11). Screening of patient IgGs against overlapping peptides spanning the gD2 ectodomain revealed that about half of the samples contained antibodies against linear epitopes within the N and C termini of gD2. We found that the virus-neutralizing abilities of the 10 most potent samples correlated with overall gD-binding activity and to an even greater extent with the combined content of IgGs against the epitopes of MAbs MC2, MC5, MC23, and DL11. This suggests that optimal virus-neutralizing activity is achieved by strong and balanced responses to the four major discontinuous neutralizing epitopes of gD2. Importance: Several herpes simplex virus 2 (HSV-2) subunit vaccine studies have been conducted in human subjects using a recombinant form of HSV-2 glycoprotein D (gD2). Although several distinct, well-characterized virus-neutralizing epitopes on gD2 are targeted by murine monoclonal antibodies, it is not known whether the same epitopes are targeted by the humoral response to gD2 in humans. We have developed a novel, biosensor-based competition assay to directly address this important question. Using this approach, we identified epitopes that elicit strong humoral responses in humans, as well as other epitopes that elicit much weaker responses. These data provide new insight into the human response to known neutralizing gD2 epitopes and reveal characteristics of this response that may guide future vaccine development.
Optical MEMS filter for infrared gas detection (2008)

An optical filter is proposed, which can be adapted to infrared detection of various gases. The filter is based on a diffraction grating structured on a micro-electro-mechanical system (MEMS) which can be switched between two states by applying an external actuation voltage of 0-5V. The optical grating is etched into silicon, and has a period and a depth adapted to the gas to be detected. The grating presented in this poster is a two-level binary grating designed to give a reflection spectrum centred at a 2μm wavelength. It has 500nm deep grooves and has a period of 5- 10μm. The grating is structured on top of an array of silicon beams, where every second beam can be moved vertically. The filter switches between two states by applying an actuation voltage of 0V and 5V. The optical spectrum of the diffracted light changes according to actuation voltage. By deflecting every second grating element 500nm (λ/4) vertically, the filter can be switched between a function with a single band which peaks at a certain centre wavelength, and a function with two sidebands positioned on either side of the centre wavelength. The single band can be designed to coincide with the absorption lines of the gas to be detected, while the sidebands are positioned outside of the absorption region of the gas. By illuminating the gas with light diffracted off this filter and switching between the two filter states, an intensity modulation of the light is achieved which is dependent upon the amount of gas present in the transmission path of the light. The proposed filter provides a robust, flexible, and potentially low cost solution for infrared gas detection of a wide range of gases.
Galectin binding to and expression modulation by viruses in zebrafish (89.51) (2010)

Abstract The galectin family of β-galactoside-binding proteins is evolutionarily conserved. Galectins are known to interact with and affect the infectivity and/or pathogenicity of several viruses. We hypothesize that galectin interactions with viruses influence anti-viral immune responses. We investigate the interactions of zebrafish galectins with the glycosylated (G) protein of the rhabdovirus IHNV. We (a) characterized the carbohydrates present on IHNV proteins, and (b) identified direct interactions between zebrafish galectins (Drgal) and IHNV. We assessed the effects of immune challenge on (c) galectin and (d) cytokine expression in zebrafish. Several IHNV proteins exhibit complex glycosylation patterns. One or multiple IHNV proteins exhibit terminally linked mannose, sialic acid terminally linked to galactose, galactose-β(1-3)-GalNAc, sialic acid terminally linked to galactose or GalNAc, and galactose-β(1-4)-GlcNAc. The proto type Drgal1-L2, the chimera type Drgal3-L1 and the tandem-repeat type Drgal9-L2 all appear to bind to one or more IHNV proteins. All tested Drgal appear to bind to the IHNV G protein. ZFL cells endogenously express mRNA encoding Drgal1-L2, -L3, and -L4, Drgal3-L1 and -L2, and Drgal9-L1 mRNA. Drgal mRNA expression in ZFL cells was not induced by treatment with polyI:C. ZFL cells were found to endogenously express mRNA encoding Mx, TNFα, and IFNαβ. Treatment of these cells with polyI:C induced the expression of mRNA encoding IL-10 and IFNγ2.