gebhart/patrepeval huggingface dataset:
Photovoltaic DC-DC converter test system (2013)

This paper describes LabVIEW based integrated measurement system to determine key parameters of DC-DC converters working in low-voltage photovoltaic (PV) systems. DC-DC converter should demonstrate high efficiency of energy conversion as well as sufficient voltage gain to yield as much energy from PV panel as it is possible. Efficiency and voltage gain can be measured across the number of parameters such as input voltage, output load, frequency and duty cycle of converter driving signals. The LabVIEW application works with both Hioki 8855 data recorder which carries out power measurements and a microcontroller Digital Driver who drives a converter tested. Measurement system allows to automate time consuming measurements as well as experimentally verify DC-DC converter design assumptions. The laboratory test results of selected DC-DC converter prototype as well as sources of error has been discussed in this paper. 1.
Evaluation of a <scp>DTPA</scp> Prodrug, <scp>C2E5</scp> as an Orally Bioavailable Radionuclide Decorporation Agent (2012)

Abstract Strategy, Management and Health Policy Enabling Technology, Genomics, Proteomics Preclinical Research Preclinical Development Toxicology, Formulation Drug Delivery, Pharmacokinetics Clinical Development Phases I‐III Regulatory, Quality, Manufacturing Postmarketing Phase IV The efficacy of the prodrug C2E5 , the pentaethyl ester of diethylenetriaminepentaacetic acid ( DTPA ), as an orally administered chelator of americium was evaluated in rats. C2E5 enhanced 241 Am decorporation over vehicle‐only controls (187 μmol/kg, 14.8 ± 4.2% vs control, 7.1 ± 1.4% injected 241 Am , P &lt; 0.05) when administered 1 h after 241 Am nitrate contamination by intramuscular (i.m.) injection. Reduction in liver burden was also achieved (375 μmol/kg, 13.1 ± 2.0% vs control, 17.3 ± 2.4% 241 Am ). Under these conditions, a single C2E5 dose did not match the efficacy of intravenous (i.v.) Ca‐DTPA (26.8 μmol/kg; decorporation 24.5 ± 3.5% and liver burden 10.2 ± 2.7% 241 Am ). Dividing the 375 μmol/kg C2E5 dose enhanced efficacy (4 × 94.5 μmol/kg C2E5 ; decorporation 19.7 ± 4.5% and liver burden 11.5 ± 2.8% 241 A m; P &lt; 0.001, P &lt; 0.05 vs control), approaching parity with i.v. Ca‐DTPA . When the contamination model was changed to i.v. or i.m. 241 Am citrate injection, C2E5 (75 μmol/kg) enhanced decorporation and reduced liver burden. Higher doses of C2E5 (375 μmol/kg) were comparable with i.v. Ca‐DTPA (26.8 μmol/kg), with liver burdens at 3.2 ± 1.4% and 7.4 ± 2.7%, and decorporation of 43.5 ± 8.9% and 37.4 ± 3.9% i.m. 241 Am citrate, respectively. The differences observed in oral C2E5 efficacy relative to i.v. Ca‐DTPA between contamination models may be related to the kinetics of the injected americium complex. C2E5 proved to be an effective decorporation agent for 241 Am when orally administered and may be improved by optimized treatment strategies.
Systems‐Based Analysis of the Pancreatic Cancer‐Specific Glycome Reveals ST6GAL1 as a Driver of Human and Murine Disease (2021)

Pancreatic ductal adenocarcinoma (PDA) is the 3 rd leading cause of cancer‐death in the U.S.. Glycans, such as CA‐19‐9, are biomarkers of PDA, but their roles in PDA biology are unclear. Herein, we utilized lectin microarray technology to compare the glycomes of human and murine PDA. We observed common aberrant patterns of glycosylation across both species, including increased levels of α‐2,3‐ and α‐2,6‐sialic acids, bisecting GlcNAc and poly‐LacNAc. Using single cell sequencing and histological data, we identified ST6GAL1, which underlies α‐2,6‐sialic acid, as a potential driver in human PDA. We created a novel mouse in which a pancreas‐specific genetic deletion of ST6GAL1 overlays the well‐established KC mouse model. Analysis of our model showed delayed cancer formation and a significant reduction in fibrosis. Our results highlight the utility of the KC model as an accurate reflection of human disease and identify ST6GAL1 as a key driver of pancreatic cancer initiation and progression.
Locked Plating versus Nailing for Proximal Tibia Fractures: A Multicenter RCT (2023)

Therapeutic Level II. See Instructions for Authors for a complete description of levels of evidence.
Agencia de autocuidado en hipertensos usuarios de un hospital universitario en Cúcuta (Colombia) (2014)

Objective: The objective of this study was to describe the ability of self-care agency service users hypertensive external consultation of the University Hospital Erasmo Meoz, in Cucuta. Materials and Methods: this was a cross-sectional study of a quantitative conducted during the first half of 2012, volunteers who required to have completed Questionary of Capacity of Agency of self-care. Results: The overall levels of self care were as follows: 83.1% showed a low self care capac-ity, 6.2 % showed average self care capacity and 10.8 % showed a high capacity. The same trend was found with the promotion and operation categories of personal development, personal interaction, and activity and rest. Conclusions: The results obtained in this study allow to comprehensively assess the effect on the ability of the self-care agency in the participants. This confirms the importance of nursing forceful work in strengthening these people as being able to use reason to under-stand their health, making decisions for specific action and generate favourable behavior towards their own care.
Combined inhibition of PI3K delta and FLT3 signaling exerts synergistic antitumor activity and overcomes acquired drug resistance in FLT3-activated acute myeloid leukemia (2018)

PI3K delta (phosphatidylinositol-4,5-bisphosphate 3-kinase delta) and FLT3 (fms-related tyrosine kinase 3) are frequently activated in acute myeloid leukemia (AML) and have been implicated as potential therapeutic targets. In this report, we demonstrate that combined inhibition of PI3K delta and FLT3 exerts synergistic antitumor activity in FLT3-activated AML. Synergistic antiproliferative effects were observed in FLT3-activated MV-4-11 and EOL-1 AML cell lines, but not in FLT3-independent RS4;11 and HEL cells, as demonstrated by both pharmacological inhibition and silencing of PI3K delta/FLT3. Combined treatment with PI3K delta and FLT3 inhibitors more effectively inhibited phosphorylation of AKT and ERK (extracellular signal-regulated kinase), and induced apoptosis more efficiently than either agent alone. This synergistic effect was confirmed in hematopoietic 32D cells transfected with an FLT3-ITD (internal tandem duplication) mutant, but not FLT3 wild type. In in vivo FLT3-activated AML xenografts, a PI3K delta inhibitor combined with FLT3 inhibitor led to significantly enhanced antitumor activity compared with either agent alone, in association with simultaneous inhibition of AKT and ERK, with no additional toxicity. Importantly, the PI3K delta inhibitor CAL101 combined with FLT3 inhibitors overcame acquired drug resistance in FLT3-ITD AML cells. Thus, combined inhibition of PI3K delta and FLT3 may be a promising strategy in FLT3-activated AML, particularly for patients with FLT3-inhibitor resistant mutations.
Influence of the Linking Order of Fragments of HA2 and M2e of the influenza A Virus to Flagellin on the Properties of Recombinant Proteins (2018)

The ectodomain of the M2 protein (M2e) and the conserved fragment of the second subunit of hemagglutinin (HA2) are promising candidates for broadly protective vaccines. In this paper, we report on the design of chimeric constructs with differing orders of linkage of four tandem copies of M2e and the conserved fragment of HA2 (76-130) from phylogenetic group II influenza A viruses to the C-terminus of flagellin. The 3D-structure of two chimeric proteins showed that interior location of the M2e tandem copies (Flg-4M2e-HA2) provides partial α-helix formation nontypical of native M2e on the virion surface. The C-terminal position of the M2e tandem copies (Flg-HA2-4M2e) largely retained its native M2e conformation. These conformational differences in the structure of the two chimeric proteins were shown to affect their immunogenic properties. Different antibody levels induced by the chimeric proteins were detected. The protein Flg-HA2-4M2e was more immunogenic as compared to Flg-4M2e-HA2, with the former offering full protection to mice against a lethal challenge. We obtained evidence suggesting that the order of linkage of target antigens in a fusion protein may influence the 3D conformation of the chimeric construct, which leads to changes in immunogenicity and protective potency.
Survivin does not inhibit caspase-3 activity (2000)

Conway et al recently reported that alternatively spliced forms of mouse survivin exhibit different antiapoptotic properties.[1][1] This was inferred from inhibition of recombinant caspase-3 catalytic activity using a standard chromogenic assay in the presence of increasing concentrations of
Virological and Immunological Long-Term Outcome of Human Immunodeficiency Virus-1 Infected Children Treated before One Year and after Two Years of Age in a Resource-Limited Setting of South Africa (2017)

INTRODUCTION: Benefits of early Highly Active AntiRetroviral Therapy (HAART) to reduce infant mortality and morbidity have been demonstrated in resource-limited and rich settings. However, immunovirological data collected in Sub-Saharan Africa are scarce. This study describes the long-term outcome of South African children who started HAART before one year of age (Early Starters Cohort or ESC) and compare their immunovirological outcomes to children who started their therapy after two years of age (Late Starters Cohort or LSC). Immunovirological results will be compared in order to evaluate the long-term non-inferiority of early treatment initiation. METHODS: Fifty-five children were included in the ESC (mean follow-up period 7.9 years) and 96 children were included in the LSC (mean follow-up period 6.3 years). Children from the ESC and the LSC were subdivided into three subgroups according to CD4+% at HAART initiation (&lt;15%, between 15-24% and ≥ 25%). RESULTS: All children included in the ESC achieved normal CD4% at least once during the entire follow-up period, contrary to the LSC where 89.6% children achieved normal CD4% (p=0.014). Furthermore, mean CD4+% became higher in the ESC six years after treatment initiation. Children with CD4+% between 15 and 24% at HAART initiation reached higher CD4+% in the ESC, three years after treatment initiation. The proportion of children who experienced virological failure (&gt;100 cp/ml) was comparable in both cohorts but persistent undetectable viral load (&lt;50 cp/ml) after initial virological suppression was more frequent in the ESC (p=0.008). Finally, the proportion of children with detectable viral loads (50 to 1000 cp/ml) at least one time during the entire follow-up period was higher in the LSC (p=0.0022). CONCLUSION: HAART appeared highly effective in terms of immunovirological outcomes both in children treated before one and after two years of age. The results of this study demonstrate that early treated children more often achieved normal CD4+%, tended to have higher mean CD4+% and more sustained virological suppression. These results encourage the current international recommendations to initiate HAART as soon as possible in RLS.
A geometrical optics approach for modeling aperture averaging in free space optical communication applications (2006)

Intensity fluctuations at the receiver in free space optical (FSO) communication links lead to a received power variance that depends on the size of the receiver aperture. Increasing the size of the receiver aperture reduces the power variance. This effect of the receiver size on power variance is called aperture averaging. If there were no aperture size limitation at the receiver, then there would be no turbulence-induced scintillation. In practice, there is always a tradeoff between aperture size, transceiver weight, and potential transceiver agility for pointing, acquisition and tracking (PAT) of FSO communication links. We have developed a geometrical simulation model to predict the aperture averaging factor. This model is used to simulate the aperture averaging effect at given range by using a large number of rays, Gaussian as well as uniformly distributed, propagating through simulated turbulence into a circular receiver of varying aperture size. Turbulence is simulated by filling the propagation path with spherical bubbles of varying sizes and refractive index discontinuities statistically distributed according to various models. For each statistical representation of the atmosphere, the three-dimensional trajectory of each ray is analyzed using geometrical optics. These Monte Carlo techniques have proved capable of assessing the aperture averaging effect, in particular, the quantitative expected reduction in intensity fluctuations with increasing aperture diameter. In addition, beam wander results have demonstrated the range-cubed dependence of mean-squared beam wander. An effective turbulence parameter can also be determined by correlating beam wander behavior with the path length.
On the Communication Cost of Determining an Approximate Nearest Lattice Point (2017)

We consider the closest lattice point problem in a distributed network setting and study the communication cost and the error probability for computing an approximate nearest lattice point, using the nearest-plane algorithm, due to Babai. Two distinct communication models, centralized and interactive, are considered. The importance of proper basis selection is addressed. Assuming a reduced basis for a two-dimensional lattice, we determine the approximation error of the nearest plane algorithm. The communication cost for determining the Babai point, or equivalently, for constructing the rectangular nearest-plane partition, is calculated in the interactive setting. For the centralized model, an algorithm is presented for reducing the communication cost of the nearest plane algorithm in an arbitrary number of dimensions.
Minimizing poly end cap pull back by application of DFM and advanced etch approaches for 65nm and 45 nm technologies (2007)

As feature sizes decrease and the overall design shrinks, it is becoming increasingly difficult to reliably pattern gate line ends, or poly end caps, so that they are able to extend over to the field area without bridging into an adjacent feature. Furthermore, the trimming of the lines during the gate etch process is necessary due to the desire to decrease the poly length. However, the line end is also trimmed while trimming the gate sidewall, often at higher rates than the sidewall itself. This investigation focuses on decreasing the poly line end pullback, defined as the tip of the gate past active, using lithography techniques and advanced etch approaches for the 65 nm and 45 nm nodes.
Flow field around a vibrating cantilever: coherent structure eduction by continuous wavelet transform and proper orthogonal decomposition (2011)

The velocity field around a vibrating cantilever plate was experimentally investigated using phase-locked particle image velocimetry. Experiments were performed at Reynolds numbers of Re h = 101, 126 and 146 based on the tip amplitude and the speed of the cantilever. The averaged vector fields indicate a pseudo-jet flow, which is dominated by vortical structures. These vortical structures are identified and characterized using the continuous wavelet transform. Three-dimensional flow features are also clearly revealed by this technique. Furthermore, proper orthogonal decomposition was used to investigate regions of vortex production and breakdown. The results show clearly that the investigation of phase-averaged data hides several key flow features. Careful data post-processing is therefore necessary to investigate the flow around the vibrating cantilever and similar highly transient periodic flows.
Smart energy case study (2012)

As the world moves towards renewable energy production, the importance of involving energy-consumers into the process of scheduling energy increases. In this paper we investigate which devices should be used to balance energy consumption to match its availability. We classify electrical devices in categories that can either start consuming energy when available or can be stopped when there are low levels of energy available. We built a prototype system that enables any household to use its electrical appliances to load balance its consumption using information on how a user has configured its appliance available to a central energy distribution system. We simulated two algorithms that could be used at an energy provider to make use of the information on how users have configured their appliances for load balancing. We present our results and a recommendation on the algorithm that can be used for load balancing on the consumer side.
Scattering properties of biological cells (1998)

Optical light scattering properties of malignant and nonmalignant cells, and organelles isolated from these cells reveals information about scattering centers.
Hydrogenation of Imines Catalyzed by a Zwitterionic Rhodium Complex (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrogenation of Imines Catalyzed by a Zwitterionic Rhodium ComplexZhongxin Zhou, Brian R. James, and Howard AlperCite this: Organometallics 1995, 14, 9, 4209–4212Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/om00009a024https://doi.org/10.1021/om00009a024research-articleACS PublicationsRequest reuse permissionsArticle Views199Altmetric-Citations21LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Annual Technology Baseline: The 2020 Transportation Update (2020)

Consistent cost and performance data for various transportation technologies can be difficult to find and may change frequently for certain technologies. With the Annual Technology Baseline (ATB), the National Renewable Energy Laboratory annually provides an organized and centralized set of such cost and performance data. The ATB uses the best information from the Department of Energy national laboratories' transportation analysts. The ATB has been reviewed by experts and it includes powertrains such as gasoline, diesel, natural gas, hybrid, plug-in hybrid, battery electric, and fuel cell, as well as fuels such as gasoline, ethanol, diesel, biodiesel, natural gas, electricity, and hydrogen.
Carfilzomib is an effective upfront treatment in AL amyloidosis patients with peripheral and autonomic neuropathy (2019)

Bortezomib is standard treatment in AL amyloidosis (AL), but is contraindicated in patients with significant neuropathy. Carfilzomib, a second-generation proteosomal inhibitor, results in a lower incidence of neuropathy than bortezomib, but data in AL is scant. We report a cohort of five AL patients treated with upfront carfilzomib. All had cardiac, peripheral and autonomic neuropathy at presentation. All achieved at least a very good partial haematological response. There was no worsening in cardiac function, peripheral or autonomic neuropathy. Carfilzomib is an effective upfront treatment option in AL patients with peripheral and/or autonomic neuropathy (without severe cardiac or renal involvement).
Early PET analysis to identify responders to erlotinib treatment of advanced NSCLC. (2010)

e18092 Background: EGFR mutations predict response to erlotinib treatment in advanced NSCLC. However, identification of EGFR mutations is not always possible due to lack of adequate tissue. We therefore investigated whether early PET might be a suitable tool to identify EGFR mutation positive responders. Methods: Six patients with NSCLC stage IIIB/IV showing partial remission according to RECIST criteria to first-line erlotinib treatment were analyzed and compared to 31 patients without response to first-line treatment with erlotinib. All patients were examined by [18F] FLT-PET and [18F] FDG-PET at baseline and after 1 week of treatment with erlotinib. The change in the sum of the maximum standard uptake value (sSUVmax) was calculated. Mutational status in each patient was analyzed by conventional Sanger sequencing. In case of negative results parallel sequencing using 454 technology was performed (EudraCT number 2005-005393-73; NCT00568841). Results: The median PFS for the 6 responding patients was 412 days. The mean reduction in the sSUV max was 37% (16-61) for [18F] FDG and 33% (0-55) for [18F] FLT after 1 week of treatment. Sanger sequencing of tissue available for molecular analyses revealed a sensitizing EGFR mutation in 3 of these 6 patients. Using the highly sensitve 454 technology an EGFR mutation could be demonstrated in 1 further patient. In the remaining two patients there was no diagnostic material allowing further molecular analyses. By comparison, the mean change in sSUVmax in patients not responding to erlotinib (n=31) was + 3% for [18F] FLT and -3% for [18F] FDG (p<0.005, T test). In the ROC analysis the AUC was calculated with 0.88 (0.73-1.00, p=0.004) for detection of response. Conclusions: Early [18F] FLT-PET and [18F] FDG-PET might be a suitable tool to detect patients with sensitizing EGFR mutations when treated with erlotinib. This might circumvent EGFR mutational analyses in patients with insufficient diagnostic material and enable early prediction of clinical response. Pat ID Histology Sanger 454 Change in sSUVmax LT-PET Change in sSUVmax FDPET 01-08 Adeno 0 del exon 19 -30 -44 01-18 Adeno del exon 19 N/A -44 -16 01-27 Adeno 0 N/A -55 -61 01-31 Adeno 0 N/A -39 -45 01-28 Adeno del exon 19 N/A 0 -38 01-25 Adeno L858R N/A -30 -22 Author Disclosure Employment or Leadership Position Consultant or Advisory Role Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Roche Roche Roche
Improving the DVB-T2 BICM performance by newly optimized Two-Dimensional Non-Uniform Constellations (2014)

This paper focuses on the potential enhancements of the DVB-T2 standard by the use of newly designed Two-Dimensional Non-Uniform Constellations (2D-NUQAM). In this work, a complete analysis of the DVB-T2 system performance when using the proposed 2D-NUQAM constellations against regular uniform (M-QAM) is presented. Based on the optimization of the Bit-interleaved Coded Modulation (BICM) capacity, the designed constellations provide a potential performance improvement of 1.05 dB for the overall DVB-T2 system performance in high order constellations. All carried out analyses are based on a complete DVB-T2 system specification simulation where equivalent 64-QAM and 256-QAM constellation and all baseline code rates have been evaluated.