gebhart/patrepeval huggingface dataset:
Constructing implicit 3D shape models for pose estimation (2009)

We present a system that constructs “implicit shape models” for classes of rigid 3D objects and utilizes these models to estimating the pose of class instances in single 2D images. We use the framework of implicit shape models to construct a voting procedure that allows for 3D transformations and projection and accounts for self occlusion. The model is comprised of a collection of learned features, their 3D locations, their appearances in different views, and the set of views in which they are visible. We further learn the parameters of a model from training images by applying a method that relies on factorization. We demonstrate the utility of the constructed models by applying them in pose estimation experiments to recover the viewpoint of class instances.
Online Recovery of Temporally Correlated Sparse Signals Using Multiple Measurement Vectors (2015)

This work addresses the problem of sequential recovery of temporally correlated sparse vectors with common support from noisy under-determined linear measurements. The Kalman sparse Bayesian learning (SBL) algorithm is an efficient tool for solving the problem when the temporal correlation is modeled using a first order autoregressive model. However, this method processes the input data in a batch mode, which results in high latency. We propose two online SBL algorithms which operate on the observations in a serial fashion. They are sequential expectation maximization (EM) schemes, implemented using fixed lag smoothing and sawtooth lag smoothing. The online algorithms require significantly lower computational and memory resources compared to their offline counterparts. Also, estimates of the sparse vectors become available after a fixed delay from the time observations arrive. Using Monte Carlo simulations, we illustrate that the mean square error and support recovery performance of the proposed algorithms is very close to the offline Kalman SBL algorithm.
Pyrazolyl-bridged iridium dimers. 8. Two-center, electrophilic addition of activated acetylenes to bis(cycloocta-1,5-diene)bis(.mu.-pyrazolyl)diiridium(I) leading to a diiridacyclobutene configuration: regular, parallel coordination of methyl propiolate (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPyrazolyl-bridged iridium dimers. 8. Two-center, electrophilic addition of activated acetylenes to bis(cycloocta-1,5-diene)bis(.mu.-pyrazolyl)diiridium(I) leading to a diiridacyclobutene configuration: regular, parallel coordination of methyl propiolateGordon W. Bushnell, Michael J. Decker, Donald T. Eadie, Stephen R. Stobart, Rahmatollah Vefghi, Jerry L. Atwood, and Michael J. ZaworotkoCite this: Organometallics 1985, 4, 12, 2106–2111Publication Date (Print):December 1, 1985Publication History Published online1 May 2002Published inissue 1 December 1985https://pubs.acs.org/doi/10.1021/om00131a007https://doi.org/10.1021/om00131a007research-articleACS PublicationsRequest reuse permissionsArticle Views85Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Perfect-lens-material condition from adjacent absorptive and gain resonances: erratum (2010)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text Kevin�J. Webb and Lars Thylén, "Perfect-lens-material condition from adjacent absorptive and gain resonances: erratum," Opt. Lett. 35, 1190-1190 (2010) Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Dopamine D4 receptor variant in Africans, D4Valine194Glycine, is insensitive to dopamine and clozapine: Report of a homozygous individual (1996)

The D4Valine194Glycine receptor is a variant of the dopamine D4 receptor and is found in 12.5% of the Afro-Caribbean population. Glycine replaces valine at a position one amino acid away from a serine which is critical for the attachment of dopamine. To determine whether this mutation had an effect on the properties of the dopamine D4 receptor, we constructed this variant and tested the sensitivity of the expressed protein with various drugs. We found that the variant receptor was two orders of magnitude less sensitive to dopamine, clozapine and olanzapine. The variant receptor was insensitive to guanine nucleotide, indicating the absence of a high-affinity state or functional state. The one 15-year-old individual found homozygous for this variant also had sickle cell disease. The patient revealed an overall pattern of low weight and no axillary or pubic hair.
Optimizing VLP production in gene therapy: Opportunities and challenges for <i>in silico</i> modeling (2023)

Over the past decades, virus-like particle (VLP)-based gene therapy (GT) evolved as a promising approach to cure inherited diseases or cancer. Tremendous costs due to inefficient production processes remain one of the key challenges despite considerable efforts to improve titers. This review aims to link genome-scale metabolic models (GSMMs) to cell lines used for VLP synthesis for the first time. We summarize recent advances and challenges of GSMMs for Chinese hamster ovary (CHO) cells and provide an overview of potential cell lines used in GT. Although GSMMs in CHO cells led to significant improvements in growth rates and recombinant protein (RP)-production, no GSMM has been established for VLP production so far. To facilitate the generation of GSMM for these cell lines we further provide an overview of existing omics data and the highest production titers so far reported.
UA62784, a novel inhibitor of centromere protein E kinesin-like protein (2009)

Pancreatic carcinoma is the fourth leading cause of death from cancer. Novel targets and therapeutic options are needed to aid in the treatment of pancreatic cancer. The compound UA62784 is a novel fluorenone with inhibitory activity against the centromere protein E (CENP-E) kinesin-like protein. UA62784 was isolated due to its selectivity in isogenic pancreatic carcinoma cell lines with a deletion of the DPC4 gene. UA62784 causes mitotic arrest by inhibiting chromosome congression at the metaphase plate likely through inhibition of the microtubule-associated ATPase activity of CENP-E. Furthermore, CENP-E binding to kinetochores during mitosis is not affected by UA62784, suggesting that the target lies within the motor domain of CENP-E. UA62784 is a novel specific inhibitor of CENP-E and its activity suggests a potential role for antimitotic drugs in treating pancreatic carcinomas.
Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway (2010)

Cellular responses to drug treatment show tremendous variations. Elucidating mechanisms underlying these variations is critical for predicting therapeutic responses and developing personalized therapeutics. Using a small molecule screening approach, we discovered how a disease causing allele leads to opposing cell fates upon pharmacological perturbation. Diverse microtubule-depolymerizing agents protected mutant huntingtin-expressing cells from cell death, while being toxic to cells lacking mutant huntingtin or those expressing wild-type huntingtin. Additional neuronal cell lines and primary neurons from Huntington disease mice also showed altered survival upon microtubule depolymerization. Transcription profiling revealed that microtubule depolymerization induced the autocrine growth factor connective tissue growth factor and activated ERK survival signaling. The genotype-selective rescue was dependent upon increased RhoA protein levels in mutant huntingtin-expressing cells, because inhibition of RhoA, its downstream effector, Rho-associated kinase (ROCK), or a microtubule-associated RhoA activator, guanine nucleotide exchange factor-H1 (GEF-H1), all attenuated the rescue. Conversely, RhoA overexpression in cells lacking mutant huntingtin conferred resistance to microtubule-depolymerizer toxicity. This study elucidates a novel pathway linking microtubule stability to cell survival and provides insight into how genetic context can dramatically alter cellular responses to pharmacological interventions.
Preparation, Characterization and Solubilities of Adsorbed and Co‐Precipitated Iron (III)‐Arsenate Solids (2003)

This chapter contains sections titled: Introduction Experimental Results and Discussion Conclusions Acknowledgements
Design of Mixed Electron- and Ion-Conducting Radical Polymer-Based Blends (2021)

Mixed electron- and ion-conducting polymers have received considerable interest over the last few years due to their applicability in a variety of organic electronic devices. To achieve this mixed conduction, researchers tend to rely on copolymerizing or blending two polymers, where one conducts ions and the other conducts electrons. Despite their potential as solid-state charge conductors, radical polymers have received less attention than their conjugated counterparts. This work addresses this unmet opportunity by developing a blended radical polymer poly(4-glycidyloxy-2,2,6,6-tetramethylpiperidine-1-oxyl) (PTEO), poly(poly(ethylene oxide) methyl ether methacrylate) (PPEGMA), and lithium hexafluorophosphate system. PPEGMA, similar to previous publications, had one of the highest polymer-based room-temperature ionic conductivity of 10–4 S cm–1. In addition to conducting charges, PTEO had an ionic conductivity of 10–6 S cm–1. A blend of the two polymers at equal weight ratios had a room-temperature ionic conductivity of 10–4 S cm–1 and an electronic conductivity of 10–2 S cm–1 similar to pristine PPEGMA and PTEO thin films, respectively. This similarity resulted from the formation of distinct pathways of ion (i.e., through PPEGMA domains) and electron (i.e., through PTEO domains) conduction due to microscale phase separation between the two polymers with the lithium ions mainly incorporating in the PPEGMA domains. With the addition of lithium salt, the electronic conductivity of the blend increased by 1.7 times. However, at [Li+]/[O] ratios higher than 0.08, the electronic conductivity suffered due to poor film quality. Ultimately, this effort establishes a template for determining mixed conduction in radical polymer-based blends and for developing the next generation of simultaneous conduction devices.
A Modified Risk Assessment to Establish Molybdenum Standards for Land Application of Biosolids (2001)

The USEPA standards (40 CFR Part 503) for the use or disposal of sewage sludge (biosolids) derived risk-based numerical values for Mo for the biosolids --> land --> plant --> animal pathway (Pathway 6). Following legal challenge, most Mo numerical standards were withdrawn, pending additional field-generated data using modern biosolids (Mo concentrations <75 mg kg(-1) and a reassessment of this pathway. This paper presents a reevaluation of biosolids Mo data, refinement of the risk assessment algorithms, and a reassessment of Mo-induced hypocuprosis from land application of biosolids. Forage Mo uptake coefficients (UC) are derived from field studies, many of which used modern biosolids applied to numerous soil types, with varying soil pH values, and supporting various crops. Typical cattle diet scenarios are used to calculate a diet-weighted UC value that realistically represents forage Mo exposure to cattle. Recent biosolids use data are employed to estimate the fraction of animal forage (FC) likely to be affected by biosolids applications nationally. Field data are used to estimate long-term Mo leaching and a leaching correction factor (LC) is used to adjust cumulative biosolids application limits. The modified UC and new FC and LC factors are used in a new algorithm to calculate biosolids Mo Pathway 6 risk. The resulting numerical standards for Mo are cumulative limit (RPc)=40 kg Mo ha(-1), and alternate pollutant limit (APL) = 40 mg Mo kg(-1) We regard the modifications to algorithms and parameters and calculations as conservative, and believe that the risk of Mo-induced hypocuprosis from biosolids Mo is small. Providing adequate Cu mineral supplements, standard procedure in proper herd management, would augment the conservatism of the new risk assessment.
Detection of ATM germline variants by the p53 mitotic centrosomal localization test in BRCA1/2-negative patients with early-onset breast cancer (2016)

These data validate p53-MCL as reliable and specific test for germline ATM variants, confirm ATM as breast cancer susceptibility gene, and highlight a possible association with breast/thyroid cancers.
Distinct Brain Vascular Cell Types Manifest Inducible Cyclooxygenase Expression as a Function of the Strength and Nature of Immune Insults (2002)

Induced prostanoid synthesis by cells associated with the cerebral vasculature has been implicated in mediating immune system influences on the CNS, but the cell type(s) involved remain unsettled. To determine whether this might derive from differences in the nature and intensity of the stimuli used to model immune insults, immunochemical and hybridization histochemical methods were used to monitor cyclooxygenase-2 (COX-2) expression alone, or in conjunction with endothelial, perivascular, and glial cell markers, in brains of rats treated with varying doses of interleukin-1 (IL-1) or bacterial lipopolysaccharide (LPS). Vehicle-treated animals displayed weak COX-2 expression in the meninges, choroid plexus, and larger blood vessels. Rats challenged intravenously with IL-1beta (1.87-30 microgram/kg) showed a marked increase in the number of vascular-associated cells displaying COX-2-immunoreactivity (ir). More than 90% stained positively for the ED2 macrophage differentiation antigen, identifying them as perivascular cells, whereas none coexpressed endothelial or glial cell markers. Low doses of LPS (0.1 microgram/kg) elicited a similar response profile, but higher doses (2-100 microgram/kg) provoked COX-2 expression in a progressively greater number of cells exhibiting distinct round or multipolar morphologies, corresponding to cells expressing endothelial (RECA-1) or perivascular (ED2) cell antigens, respectively. Similarly, ultrastructural analysis localized COX-2-ir to the perinuclear region of endothelial cells of LPS-treated but not IL-1-treated rats. We conclude that perivascular cells exhibit the lower threshold to COX-2 expression in response to either IL-1 or endotoxin treatment, and that enzyme expression by endothelial cells requires one or more facets of the more complex immune stimulus presented by LPS.
An endogenous calcium oscillator may control early embryonic division (1997)

Transient elevations in the concentration of free cytosolic calcium ion ([Ca2+]i) promote cell phase transitions in early embryonic division and persist even if these transitions are blocked. These observations suggest that a [Ca2+]i oscillator is an essential timing element of the early embryonic "master clock." We explore this possibility by coupling a [Ca2+]i oscillator model to an early embryonic cell cycle model based on the protein interactions that govern the activity of the M-phase-promoting factor (MPF). We hypothesize three dynamical states of the MPF system and choose parameter sets to represent each. We then investigate how [Ca2+]i dynamics may control early embryonic division in both sea urchin and Xenopus embryos. To investigate both systems, distinct [Ca2+]i profiles matching those observed in sea urchin embryos (in which [Ca2+]i exhibits sharp transients) and Xenopus embryos (in which [Ca2+]i is elevated and oscillates sinusoidally) are imposed on each of the hypothesized dynamical states of MPF. In the first hypothesis, [Ca2+]i oscillations entrain the autonomous MPF oscillator. In the second and third hypotheses, where the MPF system rests in excitatory and bistable states, respectively, [Ca2+]i oscillations drive MPF activation cycles. Simulation results show that hypotheses two and three, in which a [Ca2+]i oscillator is a fundamental timing element of the master clock, best account for key experimental observations and the questions that they raise. Finally, we propose experiments to elucidate further [Ca2+]i regulation and the fundamental components of the early embryonic master clock.
Electromechanical coupling constant extraction of thin-film piezoelectric materials using a bulk acoustic wave resonator (1998)

Thin-film piezoelectric materials such as ZnO and AlN have great potential for on-chip devices such as filters, actuators and sensors. The electromechanical coupling constant is an important material parameter which determines the piezoelectric response of these films. This paper presents a technique based on the Butterworth Van-Dyke (BVD) model which, together with a simple one-mask over-moded resonator, can be used to extract the bulk, one-dimensional electromechanical coupling constant K(2) of any piezoelectrically active thin-film. The BVD model is used to explicitly define the series resonance, parallel resonance, and quality factor Q of any given resonating mode. Common methods of defining the series resonance, parallel resonance, and Q are shown to be inaccurate for low coupling, lossy resonators such as the over-moded resonator. Specifically, an electromechanical coupling constant K(2) of (2.6+/-0.1)% was measured for an (002) c-axis textured AlN film with an X-ray diffraction rocking curve of 7.5 degrees using the BVD based extraction technique.
The canonicity of word order was a better predictor for syntactic priming and working memory measures than the active-passive syntactic manipulation in aphasia: Evidence from a verb-final language (2016)

Frontiers Events is a rapidly growing calendar management system dedicated to the scheduling of academic events. This includes announcements and invitations, participant listings and search functionality, abstract handling and publication, related events and post-event exchanges. Whether an organizer or participant, make your event a Frontiers Event!
GABA Regulates Electrical Activity and Tumor Initiation in Melanoma (2023)

This study shows evidence of GABA-mediated regulation of electrical activity between melanoma cells and keratinocytes, providing a new mechanism by which the microenvironment promotes tumor initiation. This provides insights into the role of the skin microenvironment in early melanomas while identifying GABA as a potential therapeutic target in melanoma. See related commentary by Ceol, p. 2128. This article is featured in Selected Articles from This Issue, p. 2109.
A Synthetic Cation-Transporting Calix[4]arene Derivative Active in Phospholipid Bilayers (1998)

One order of magnitude: The transport of Na<sup>+</sup> and K<sup>+</sup> ions through a phospholipid bilayer occurs with much higher conductance levels with 1 and 2 than with typical Na<sup>+</sup> -transporting proteins or gramicidin. However, the cations do not appear to pass through the calix[4]arene ring, which has a rigid 1,3-alternate conformation. diazacrown=10-benyzl-1,10-diaza[18]crown-6 group.
Reliability of rSO2 to Measure CO2 Reactivity of Cerebral Vasculatures during Desflurane-N2O Anesthesia (2002)

Background: Near infrared spectroscopy (NIRS) to monitor regional cerebral oxygen saturation (rSO2) is a noninvasive and simple modal ity in clinical use. The ability of rSO2 as an index of cerebral oxygenation has been well demonstrated. However, the reliability of rSO2 to reflect the changes of cerebral vascular reactivity in the changes of arterial partial pressure of CO2 (PaCO2) has not been established. The aim of this study was to verify the reliability of rSO2 to measure the CO2 reactivity of cerebral vasculatures.
Dynamic Behaviour of Compliant Towers in Deep Sea (2003)

For oil and gas production in deep water (&amp;gt; 500m) compliant structures are designed. By dedicated reduction of stiffness and optimization of mass (including added mass contributions) the fundamental period is tuned to about 30s, which is well above the period range of significant wave energy. This paper presents the results of a comprehensive numerical analysis of the hydroelastic behaviour of compliant towers in deep water, investigating the dynamic response of a flexible structure in a given sea state. The numerical program system is based on ADINA with an integrated hydrodynamic module for wave/structure interaction. Nonlinear effects of viscous forces are considered using Morison’s vector equation. In addition nonlinear characteristics of soil/structure interaction are also included according to API regulations. At first, for verification of the program system, the numerical results of a monotower are compared to analytical solutions obtained by modal analysis of the structure in regular and irregular seas. Based on the validated program a compliant tower installed in 503 m water in the Gulf of Mexico (Baldpate tower) is modeled in 3D, and the characteristic dynamic behavior is evaluated. Finally, the tower is exposed to a real “freak” wave (the 25.6m high New Year Wave which has been registered at the North Sea Draupner platform on January 1, 1995), and the associated loads and motions are evaluated.
Cancer and Infective Endocarditis: Characteristics and Prognostic Impact (2021)

<b>Background:</b> The interplay between cancer and IE has become of increasing interest. This study sought to assess the prevalence, baseline characteristics, management, and outcomes of IE cancer patients in the ESC EORP EURO-ENDO registry. <b>Methods:</b> Three thousand and eighty-five patients with IE were identified based on the ESC 2015 criteria. Three hundred and fifty-nine (11.6%) IE cancer patients were compared to 2,726 (88.4%) cancer-free IE patients. <b>Results:</b> In cancer patients, IE was mostly community-acquired (74.8%). The most frequently identified microorganisms were <i>S. aureus</i> (25.4%) and Enterococci (23.8%). The most frequent complications were acute renal failure (25.9%), embolic events (21.7%) and congestive heart failure (18.1%). Theoretical indication for cardiac surgery was not significantly different between groups (65.5 vs. 69.8%, <i>P</i> = 0.091), but was effectively less performed when indicated in IE patients with cancer (65.5 vs. 75.0%, <i>P</i> = 0.002). Compared to cancer-free IE patients, in-hospital and 1-year mortality occurred in 23.4 vs. 16.1%, <i>P</i> = 0.006, and 18.0 vs. 10.2%; <i>P</i> < 0.001, respectively. In IE cancer patients, predictors of mortality by multivariate analysis were creatinine > 2 mg/dL, congestive heart failure and unperformed cardiac surgery (when indicated). <b>Conclusions:</b> Cancer in IE patients is common and associated with a worse outcome. This large, observational cohort provides new insights concerning the contemporary profile, management, and clinical outcomes of IE cancer patients across a wide range of countries.