gebhart/patrepeval huggingface dataset:
Hydrothermal synthesis of sodium tungstates (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydrothermal synthesis of sodium tungstatesKenneth P. Reis, A. Ramanan, and M. Stanley WhittinghamCite this: Chem. Mater. 1990, 2, 3, 219–221Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://doi.org/10.1021/cm00009a003RIGHTS & PERMISSIONSArticle Views823Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Comparison of two electronic hand hygiene systems using real-time feedback via wireless technology to improve hand hygiene compliance in an intensive care unit (2022)

An enhanced feedback loop system connected to invasive devices, providing real-time alerts to HCWs, is effective in improving HH compliance.
Regional localization of the selenocysteine tRNA gene (TRSP) on human chromosome 19 (1992)

The human selenocysteine tRNA gene (TRSP) has been localized on chromosome 19q13.2-->q13.3 by in situ hybridization and ordered with respect to other genes and anonymous DNA markers in this region by linkage analysis in the forty CEPH pedigrees. These loci span only 10 cM in males and about 30 cM in females. The order of the loci is cen ... D19S7-D19S9-D19S47-CYP2A-CYP2F1-APOC2++ +-(TRSP, CKM). CYP2B flanks the CYP2A and CYP2F1 loci, but it cannot be determined whether it is proximal or distal to the other two cytochrome P450 loci with respect to the centromere.
The thalamic functional gradient and its relationship to structural basis and cognitive relevance (2020)

The human thalamus is an integrative hub richly connected with cortical networks, involving diverse cognitive functions. Emerging evidence suggests that multiscale structural and functional gradients integrate various information across modalities into an abstract representation. However, the presence of functional gradients in the thalamus and its relationship to structural properties and cognitive functions remain unknown. We estimated the functional gradients of the thalamus in two independent normal cohorts using a novel diffusion embedding analysis. We identified two main axes of the functional connectivity patterns, and examined associations with thalamic anatomy, morphology, intrinsic geometry, and specific behavioral relevance. We found that the dominant gradient indicated a lateral/medial axis across the thalamus and captured associations with anatomical nuclei and gray matter volume. The second gradient was an anterior/posterior axis and provided a behavioral characterization from lower level perception to higher level cognition. Furthermore, these two gradients strongly correlated with spatial distance, indicating the prominence of intrinsic geometry in functional hierarchies. These findings were replicated in an independent dataset. Overall, our findings suggested that macroscale gradients showed a coordination of structural and functional interactions, with hierarchical organization contributing to behavior characterization.
Microvascular Thrombosis, Fibrinolysis, Ischemic Injury, and Death After Cerebral Thromboembolism Are Affected by Levels of Circulating α2-Antiplasmin (2014)

a2AP has profound, dose-related effects on ischemic brain injury, swelling, hemorrhage, and survival after cerebral thromboembolism. By comparison to TPA, the protective effects of a2AP deficiency or inactivation seem to be mediated through reductions in microvascular thrombosis and matrix metalloproteinase-9 expression.
Pattern Recognition in Computational Molecular Biology:Techniques and Approaches (2015)

A comprehensive overview of high-performance pattern recognition techniques and approaches to Computational Molecular Biology This book surveys the developments of techniques and approaches on pattern recognition related to Computational Molecular Biology. Providing a broad coverage of the field, the authors cover fundamental and technical information on these techniques and approaches, as well as discussing their related problems. The text consists of twenty nine chapters, organized into seven parts: Pattern Recognition in Sequences, Pattern Recognition in Secondary Structures, Pattern Recognition in Tertiary Structures, Pattern Recognition in Quaternary Structures, Pattern Recognition in Microarrays, Pattern Recognition in Phylogenetic Trees, and Pattern Recognition in Biological Networks. Surveys the development of techniques and approaches on pattern recognition in biomolecular data Discusses pattern recognition in primary, secondary, tertiary and quaternary structures, as well as microarrays, phylogenetic trees and biological networks Includes case studies and examples to further illustrate the concepts discussed in the book Pattern Recognition in Computational Molecular Biology: Techniques and Approaches is a reference for practitioners and professional researches in Computer Science, Life Science, and Mathematics. This book also serves as a supplementary reading for graduate students and young researches interested in Computational Molecular Biology.
Erratum to: Strong predictive value of mannose-binding lectin levels for cardiovascular risk of hemodialysis patients (2016)

errors in the main text and in Tables Tables The correct Tables
Isolation and identification of xylitol dehydrogenase gene from Trichoderma reesei. (1998)

A cDNA sub-library from the fungus Trichoderma reesei grown on xylan was constructed in S.cerevisiae recombinant strain H475 harboring a xylose reductase (XR) gene from Pichia stipitis. The xylitol dehydrogenase (XDH) gene was screened from sub-library on a SC selective medium in which xylose was used as a sole carbon source. The length of XDH gene, xdh1, was about 1.3 kb. Southern, Northern and Western blots were carried out, indicating that xdh1 has high affinity with T.reesei and the molecular weight of the xylitol dehydrogenase from T.reesei was about 40 kDa. The strain HX1 harboring both the XR gene from P.stipitis and the XDH gene from T.reesei was able to grow on the xylose medium and converted more than 90% of the xylose into xylitol, ethanol, and other by-products.
Nucleotide sequence analysis and expression of the minimum REPI replication region and incompatibility determinants of pColV-K30 (1989)

We sequenced the minimum REPI replication region and the incompatibility determinants of pColV-K30. The minimum replication region contains an open reading frame which corresponds to a 35-kilodalton (kDa) protein. Sodium dodecyl sulfate-polyacrylamide gel electrophoretic analysis with maxicells transformed with a number of deletion derivatives demonstrated that this replication region encodes a 39-kDa protein and also established the direction of transcription of the RepI protein gene. The 39-kDa polypeptide was identified as the trans-acting factor essential for replication of REPI-containing plasmids. A translated region of the nucleotide sequence of the RepI protein gene showed homology with the helix-turn-helix binding domains of a number of DNA-binding proteins and also with other plasmid replication proteins. Further nucleotide analysis of the REPI region revealed the presence of direct and inverted repeat sequences in the incE, incF, and ori regions. The REPI ori also contained a perfect DnaA-binding site in addition to a high frequency of occurrence of the DNA adenine methylation (dam) site 5'GATC3'.
Polyarteritis nodosa related to hepatitis B virus. A retrospective study of 66 patients. (1992)

In an attempt to establish the characteristics, circumstances leading to infection and development of polyarteritis nodosa (PN) related to hepatitis B virus (HBV), prognostic factors and outcome, and to define the most effective treatment, 66 patients observed between 1972 and 1989 were analyzed. Hepatitis was clinically present in 19/66 patients before PN. In most cases, PN occurred less than 6 months after infection. Clinical manifestations of PN were comparable to those observed in patients without HBV infection except for orchitis which was present in 13.6% and for pulmonary signs which were absent. Transaminases were normal in 38 cases for SGOT and 31 for SGPT and twice the normal range or more in the other cases. Antineutrophil cytoplasmic antibodies (ANCA) were tested in 22 patients and present in 2 (9%). Twenty-eight patients were treated with prednisone +/- oral cyclophosphamide +/- plasma exchanges. Thirty-eight patients were given a short-term treatment with prednisone followed by the association of vidarabine, 15 mg/kg bw/d for one week and 7.5 mg/kg bw/d for 2 weeks, and plasma exchanges: 14 sessions during the 3 weeks of vidarabine infusion, then tapered until stopping treatment after 2 to 3 months depending upon the clinical results obtained. The mean duration of follow-up was 50.3 +/- 46.1 months. At the end of follow-up, 13 of the 28 patients (46.4%) treated with steroids +/- cyclophosphamide +/- plasma exchanges died and 7/38 (18.4%) of those treated with vidarabine and plasma exchanges (p < 0.001) died. HBe/anti-HBe seroconversion was observed in 2 patients treated with prednisone +/- cyclophosphamide +/- plasma exchanges who were alive at the time of final analysis and in 16 patients receiving the other regimen. The outcome of patients treated with a few days of prednisone, vidarabine and plasma exchange was good and, therefore, we propose this protocol as the first viable treatment for polyarteritis nodosa related to HBV, surpassing the conventional treatment with steroids and cyclophosphamide, which stimulates viral replication.
Neutralizing SARS-CoV-2 (2020)

Experiments with hybrid viruses are illuminating how SARS-CoV-2 can escape neutralizing antibodies.
Static properties of the passive pharynx in sleep apnea. (1996)

Complete paralysis under general anesthesia allowed separating anatomic factors from neural factors which influence pharyngeal patency. We compared static mechanical properties of the passive pharynx in normals and sleep apneics. The passive pharynx was narrower and more collapsible in sleep apneics than normal controls indicating significance of anatomic factors in the pathogenesis of obstructive sleep apnea.
Performance Comparisons of III–V and Strained-Si in Planar FETs and Nonplanar FinFETs at Ultrashort Gate Length (12 nm) (2012)

The exponential miniaturization of Si complementary metal–oxide–semiconductor technology has been a key to the electronics revolution. However, the downscaling of the gate length becomes the biggest challenge to maintain higher speed, lower power, and better electrostatic integrity for each following generation. Both industry and academia have been studying new device architectures and materials to address this challenge. In preparation for the 12-nm technology node, this paper assesses the performance of the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$ \hbox{In}_{0.75}\hbox{Ga}_{0.25}\hbox{As}$</tex></formula> of III–V semiconductor compounds and strained-Si channel nanoscale transistors with identical dimensions. The impact of the channel material property and the device architecture on the ultimate performance of ballistic transistors is theoretically analyzed. Two-dimensional and three-dimensional real-space ballistic quantum transport models are employed with band structure nonparabolicity. The simulation results indicate three conclusions: 1) the <formula formulatype="inline" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"><tex Notation="TeX">$\hbox{In}_{0.75} \hbox{Ga}_{0.25}\hbox{As}$</tex></formula> FETs do not outperform strained-Si FETs; 2) triple-gate Fin-shaped Field Effect Transistor (FinFET) surely represent the best architecture for sub-15-nm gate contacts, independently from the material choice; and 3) the simulations results further show that the overall device performance is very strongly influenced by the source and drain resistances.
X-ray Diffraction Microscopy: Computational methods and scanning-type experiments (2010)

E-Delta 2-valproic acid (E-Delta 2-VPA), a major active metabolite of VPA, has been proposed as an alternative to VPA because it is less hepatotoxic and is nonteratogenic. In rodents, VPA and E-Delta 2-VPA have a brain tissue/free plasma concentration ratio less than unity, which suggests rapid removal of the alkanoate anticonvulsants from the central nervous system. This study in rabbits employed a simultaneous iv infusion-ventriculocisternal (VC) perfusion technique to investigate the steady-state kinetics of E-Delta 2-VPA transport at the blood-brain barrier, the blood-cerebrospinal fluid (CSF) barrier, and the neural cell membrane. Probenecid (PBD) was coadministered to probe the mediation of transport by organic anion transporter(s). Rabbits in the control group (N = 6) received an iv infusion of E-Delta 2-VPA to achieve a steady-state plasma concentration of 50 to 60 microg/ml. Blood and cisternal outflow of mock CSF perfusate were continuously sampled. Midway through the experiment, the VC perfusate was switched to one containing [3H]E-Delta 2-VPA. At 225 min, the rabbits were sacrificed, and each brain was removed and dissected into ten regions. Rabbits in the PBD group (N = 9) received an iv infusion and VC perfusion as in the control group as well as concomitant iv infusion of the inhibitor. The mean steady-state VC extraction ratio for [3H]E-Delta 2-VPA did not differ between the control and PBD groups (63.7 +/- 8.3% vs. 60. 6 +/- 9.6%), indicating the lack of a significant PBD-sensitive transport at the choroidal epithelium. Coadministration of PBD elevated brain concentration of cold E-Delta 2-VPA in the absence of a significant change in total or free steady-state plasma concentration. Mean E-Delta 2-VPA brain tissue/free plasma concentration ratios in the various brain regions were 3.5- to 5.2-fold higher in PBD-treated animals than in the controls. Significant increases (3.0- to 4.5-fold) in the mean brain tissue/cisternal perfusate concentration ratios were also observed. Compartmental modeling of the steady-state distribution data suggested that clearance of E-Delta 2-VPA from the brain parenchyma is governed jointly by efflux transporters at the neural cell membrane and brain capillary endothelium. Moreover, PBD-induced elevation of E-Delta 2-VPA tissue concentrations is attributed primarily to inhibition of E-Delta 2-VPA efflux transport at the neural cell membrane, resulting in both intracellular trapping and greater tissue retention of E-Delta 2-VPA.
IMMU-73. GLIOMA IN SITU VACCINATION WITH COWPEA MOSAIC VIRUS NANOPARTICLES (2018)

Glioblastoma multiforme is the most malignant brain cancer affecting adults. Despite recent advancements, the current prognosis is dismal with median survival of 12 months post diagnosis even with multi-modal therapy. Cancer immunotherapy has made significant advances in treatment of multiple cancer types and is a promising avenue for development for glioma treatment. However, the highly immunosuppressive tumor microenvironment remains a challenge. The tumor microenvironment induces tolerance, exhaustion or death of T effector cells, protecting the tumor from most immune effector cells. Here we have utilized a 30 nm-sized virus like particle (VLP) derived from the plant virus Cowpea mosaic virus (CPMV) as an immunotherapy. The VLP is applied intratumorally as an in situ vaccine, modulating the tumor microenvironment and stimulating anti-tumor immunity. The VLPs are ingested by innate immune cells driving a cascade of immunological events, which leads to activation of the adaptive immune system and cancer cell death. We have demonstrated that weekly VLP treatment of immunocompetent mice with a high tumor burden of GL261 cells creates a localized inflammatory response that kills tumor cells. MRI imaging demonstrates GL261 tumor bearing mice have increased edema and swelling indicative of immune infiltration after treatment. Histological analysis with markers for immune cells support this finding. The ensuing immune response was also characterized using flow cytometry analysis on brain and spleen tissues and using ELISAs to determine cytokines milieu following the treatment.
Toward a Remote Assessment of Walking Bout and Speed: Application in Patients With Multiple Sclerosis (2021)

Gait speed as a powerful biomarker of mobility is mostly assessed in controlled environments, e.g. in the clinic. With wearable inertial sensors, gait speed can be estimated in an objective manner. However, most of the previous works have validated the gait speed estimation algorithms in clinical settings which can be different than the home assessments in which the patients demonstrate their actual performance. Moreover, to provide comfort for the users, devising an algorithm based on a single sensor setup is essential. To this end, the goal of this study was to develop and validate a new gait speed estimation method based on a machine learning approach to predict gait speed in both clinical and home assessments by a sensor on the lower back. Moreover, two methods were introduced to detect walking bouts during daily activities at home. We have validated the algorithms in 35 patients with multiple sclerosis as it often presents with mobility difficulties. Therefore, the robustness of the algorithm can be shown in an impaired or slow gait. Against silver standard multi-sensor references, we achieved a bias close to zero and a precision of 0.15 m/s for gait speed estimation. Furthermore, the proposed machine learning-based locomotion detection method had a median of 96.8% specificity, 93.0% sensitivity, 96.4% accuracy, and 78.6% F1-score in detecting walking bouts at home. The high performance of the proposed algorithm showed the feasibility of the unsupervised mobility assessment introduced in this study.
Enantioselective Au(I)-Catalyzed Multicomponent Annulations via Tethered Counterion-Directed Catalysis (2022)

Gold(I) complexes of a chiral phosphoric acid-functionalized phosphine of the CPA-Phos series enable the enantioselective multicomponent reactions between aldehydes, hydroxylamines and cyclic yne-enones, leading to 3,4-dihydro-1H-furo[3,4-d][1,2]oxazines. This represents a rare example of a highly enantioselective multicomponent reaction in gold(I) catalysis. The reactions proceed at a low catalyst loading and provide high yields, total diastereoselectivity, and enantiomeric excesses up to 99%. Silver-free conditions can be applied. The method has a very broad scope as it applies to both aliphatic and aromatic aldehydes and hydroxylamines, to a variety of cyclic yne-enones, and to yne-enone-derived oximes. DFT calculations complement this study to enlighten reactivity issues and mechanistic pathways.
High Peak Power Laser Technologies: New Directions (2009)

This tutorial introduces the basics of ultrashort duration laser pulse amplification and reviews present technologies for both femtosecond and kJ petawatt peak power laser systems. A survey of present worldwide efforts will also be presented.
&lt;title&gt;Simulation and properties of randomly switched control systems&lt;/title&gt; (1999)

Power electronics has made great advances since the introduction of the thyristor in 1958. Even a casual study of consumer electronics have steadily replaced passive circuits. Switched mode circuits can accommodate higher power densities, they are lighter, cheaper and easier to control. The use of microprocessors and microcontrollers can make switched mode circuits even more versatile. Unfortunately, there are some problems with switched mode circuits. The higher power densities handled by these circuits can cause catastrophic failure. Periodic switching can give rise to acoustic noise or undesirable electromagnetic radiation. These problems can be reduced through the use of random switching policies. One theoretical disadvantage of random switching policies is that the time averaged switched system is not strictly equivalent to the classical system with the same average parameters. The stability limits for the randomly switched and classical system are different. This is a possible area for concern, given the high power densities and the possibility of catastrophic failure. In this paper we examine the stability of randomly switched control systems. We provide simulations, some analysis and derive some practical rules for stability. We show that some randomness can be beneficial from the point of view of minimizing power spectral density of the noise waveforms in the output current.
Diet-induced and mono-genetic obesity alter volatile organic compound signature in mice (2016)

The prevalence of obesity is still rising in many countries, resulting in an increased risk of associated metabolic diseases. In this study we aimed to describe the volatile organic compound (VOC) patterns symptomatic for obesity. We analyzed high fat diet (HFD) induced obese and mono-genetic obese mice (global knock-in mutation in melanocortin-4 receptor MC4R-ki). The source strengths of 208 VOCs were analyzed in ad libitum fed mice and after overnight food restriction. Volatiles relevant for a random forest-based separation of obese mice were detected (26 in MC4R-ki, 22 in HFD mice). Eight volatiles were found to be important in both obesity models. Interestingly, by creating a partial correlation network of the volatile metabolites, the chemical and metabolic origins of several volatiles were identified. HFD-induced obese mice showed an elevation in the ketone body acetone and acrolein, a marker of lipid peroxidation, and several unidentified volatiles. In MC4R-ki mice, several yet-unidentified VOCs were found to be altered. Remarkably, the pheromone (methylthio)methanethiol was found to be reduced, linking metabolic dysfunction and reproduction. The signature of volatile metabolites can be instrumental in identifying and monitoring metabolic disease states, as shown in the screening of the two obese mouse models in this study. Our findings show the potential of breath gas analysis to non-invasively assess metabolic alterations for personalized diagnosis.
Stress-induced expression of the c-fos proto-oncogene in the hippocampal formation. (1994)

To investigate the effects of stress on c-fos mRNA expression, rats were submitted to forced immobilization for 15, 30, 60 or 120 min before sacrifice. In situ hybridization was performed on sections containing the dorsal hippocampus with a 32P-labelled 50-base oligonucleotide probe (10(7)-10(9) cpm/micrograms) complementary to nucleotides 370-319 of rat c-fos. Forced restraint induced a time-dependent increase in c-fos mRNA expression which was most pronounced in the dentate gyrus and CA1-CA3 regions of the hippocampal formation, and which peaked after 30 min of immobilization (72.7 +/- 1.0 vs 24.1 +/- 0.8 cpm/mm2 in unrestrained animals). A positive but weaker signal was also detected in the amygdala, pyriform cortex and other parts of the cerebral cortex and habenulae. These results suggest that the hippocampal formation is activated during stress.