gebhart/patrepeval huggingface dataset:
A sub-ns response fully integrated battery-connected switched-capacitor voltage regulator delivering 0.19W/mm&lt;sup&gt;2&lt;/sup&gt; at 73% efficiency (2013)

Lithium-ion batteries are the dominant power source in mobile devices. However, while the supply voltage required for processors and SoCs has scaled down to ~1V, the voltage range of this popular battery remains ~2.9V-4.2V (nominally ~3.6V). To bridge this voltage difference, off-chip power management ICs are typically required. Despite their high efficiency, supporting many independent, high-current supplies to e.g. a multi-core SoC is extremely challenging due to cost, area, and supply impedance concerns associated with board and package level parasitics. There is hence strong motivation for efficient, fully integrated voltage regulators (IVRs) that interface directly with the battery while supporting multiple separate on-chip supply.
A novel approach to oxazole-containing diterpenoid synthesis from plant roots: salviamines E and F (2018)

In this study, salviamines E and F, which are structurally unique abietane-type diterpene alkaloids containing an oxazole ring, were efficiently synthesized from a known molecule, 5,7,8-trimethoxy-1-naphthol. The synthetic sequence involves the following crucial steps: (i) the assembly of a carbon skeleton by coupling a six-carbon homoprenyl unit with a naphthalene moiety (Kumada-Tamao-Corriu coupling); (ii) the construction of a tricyclic phenanthrene ring by acid-induced cyclization of a naphthalene derivative with a homoprenyl side chain; (iii) the formation of an oxazole ring by nucleophilic ring closure of a 2-aminophenylene-1,4-diyl-diformate or -diacetate moiety and (iv) Friedel-Crafts acetylation at the C13 position of the tetracyclic intermediates to obtain the two target molecules, salviamines E and F. To the best of our knowledge, salviamine synthesis is reported here for the first time.
Raf promotes dimerization of the Ras G‐domain (2020)

The Ras/Raf/MEK/ERK pathway is a major regulator of cell proliferation and is highly implicated in human cancers. Ras dimerization was first proposed thirty years ago, and it is known that Ras dimerization is essential for Raf activation, yet the mechanism through which this occurs has remained elusive. Attempts to detect Ras dimers on supported membranes have led to the conclusion that Ras does not dimerize in the absence of other factors. Here we show that the Ras binding domain of Raf (Raf‐RBD) is the key element prompting Ras dimerization. A small amount of Ras/Raf‐RBD dimer is seen in solution, while the addition of Raf‐RBD to Ras on supported lipid membranes produces robust levels of dimers. On the membrane, Ras/Raf‐RBD binding and Ras dimerization appear to be concerted events that lead to a high‐affinity signaling complex. Molecular dynamics simulations of Ras and Raf‐RBD alone, in a complex, and in the dimer reveal that the proteins become increasingly connected with higher levels of allosteric networks. This is apparent in the increasing connectivity between the helices involved in dimerization, helices 4 and 5, developing more consistent communication with the phosphate binding loop in the Ras active site. These data reveal a novel mode of regulation of the mitogenic Ras/Raf/MEK/ERK pathway. Support or Funding Information NSF‐MCB‐1517295
Effect of Vagus Nerve Stimulation in an Adult Patient with Dravet Syndrome: Contribution to Sudden Unexpected Death in Epilepsy Risk Reduction? (2012)

We report on a patient who developed, from 5 months of age, multiple seizure types, including myoclonic, associated with severe psychomotor delay, leading to the diagnosis of Dravet syndrome. Over the years, he developed refractory epilepsy and was implanted with a vagus nerve stimulator at the age of 19. After 3 months, he experienced a progressive improvement of partial and generalized seizures, with a >90% reduction, and better alertness. This meaningful clinical improvement is discussed in the light of the sudden unexpected death in epilepsy risk, which is high in this setting, and seems remarkably diminished in our patient in view of the reduction of generalized convulsions.
Genetics and developing countries (2001)

With the publication of the sequence of the human genome, we can now approach our history as human beings in a way never previously possible—a history that has been written in only 30 000 or so genes. There is a completely different way of looking at history and genetics, however—one that should never be forgotten by clinicians.

Take a real case history: a 27 year old woman presents for a routine examination with a small lump on her breast. She had been seen by doctors who ignored the lump and took neither a biopsy nor an adequate history. The latest doctor to see her asked whether members of her family had had breast cancer. Both her mother and maternal grandmother died before the age of 40 from breast cancer. Whether their malignancies were caused by mutations in BRCA1 or 2, the p53, or other genes is unimportant: an adequate history would have revealed a great deal about her genetic susceptibility to disease. Classic papers, 1 2 largely but not entirely forgotten,3 point out that 70% of diagnoses can be revealed in clinical histories, with laboratory diagnosis accounting for only about 10% additional information. For clinicians in developing countries, without access to advanced diagnostic facilities but with knowledge of genetic research, a careful history can reveal much of what modern genetics and high technology can teach that is important …
Bismuth Particle Formation in Annealed Dilute GaAs i-x-y P y Bi x Alloys (2016)

Journal Article Bismuth Particle Formation in Annealed Dilute GaAs i-x-y P y Bi x Alloys Get access Z R Lingley, Z R Lingley Electronics and Photonics Laboratory, The Aerospace Corporation, El Segundo, USA Search for other works by this author on: Oxford Academic Google Scholar B Foran, B Foran Electronics and Photonics Laboratory, The Aerospace Corporation, El Segundo, USA Search for other works by this author on: Oxford Academic Google Scholar M Brodie, M Brodie Electronics and Photonics Laboratory, The Aerospace Corporation, El Segundo, USA Search for other works by this author on: Oxford Academic Google Scholar Y Sin, Y Sin Electronics and Photonics Laboratory, The Aerospace Corporation, El Segundo, USA Search for other works by this author on: Oxford Academic Google Scholar NP Wells, NP Wells Electronics and Photonics Laboratory, The Aerospace Corporation, El Segundo, USA Search for other works by this author on: Oxford Academic Google Scholar S C Moss, S C Moss Electronics and Photonics Laboratory, The Aerospace Corporation, El Segundo, USA Search for other works by this author on: Oxford Academic Google Scholar K Forghani, K Forghani Dep. of Chemical and Biological Engineering, University of Wisconsin-Madison, USA Search for other works by this author on: Oxford Academic Google Scholar Y Guan, Y Guan Dep. of Chemical and Biological Engineering, University of Wisconsin-Madison, USA Search for other works by this author on: Oxford Academic Google Scholar L Mawst, L Mawst Dep. of Electrical and Computer Engineering, University of Wisconsin-Madison, USA Search for other works by this author on: Oxford Academic Google Scholar H Kim, H Kim Dep. of Electrical and Computer Engineering, University of Wisconsin-Madison, USA Search for other works by this author on: Oxford Academic Google Scholar ... Show more T-H Kim, T-H Kim Dep. of Electrical and Computer Engineering, University of Wisconsin-Madison, USA Search for other works by this author on: Oxford Academic Google Scholar T F Kuech T F Kuech Dep. of Chemical and Biological Engineering, University of Wisconsin-Madison, USA Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 22, Issue S3, 1 July 2016, Pages 1578–1579, https://doi.org/10.1017/S1431927616008734 Published: 25 July 2016
SEQUENCES OF INTEREST: Cloning and Structure of Human Genomic DNA and Hypothalamic cDNA Encoding Human preproThyrotropin-Releasing Hormone (1990)

The gene encoding human preproTRH was isolated from a human lung fibroblast genomic DNA library with a rat prepro TRH cDNA fragment. The transcriptional unit is 3.3 kilobases in size and contains three exons interrupted by two introns of approximately 1050 and 650 base pairs, respectively. Exon 1 encodes the 5'-untranslated region of the mRNA, exon 2 the putative signal sequence and the initial portion of propeptide, and exon 3 encodes the remainder of the propeptide, which contains six copies of the TRH sequence in contrast to five copies in the rat preproTRH gene. The predicted human preproTRH peptide structure has 242 amino acids compared to 255 amino acids in the rat. Homology with rat preproTRH is 73.3% and 59.5% at the nucleic acid and amino acid levels, respectively. Intron-exon splicing sites and 5' and 3' mRNA borders were confirmed rigorously by sequencing a human preproTRH cDNA using the polymerase chain reaction and human hypothalamic cDNA.
ABC and BAC triblock copolymers ‐ morphological engineering by variation of the block sequence (1997)

Abstract Different morphologies and phase transitions of ternary triblock copolymers with different block sequences (ABC and BAC) are discussed qualitatively. The interplay between interfacial energies and elastic energies of the different blocks leads to various morphologies and enhances or prevents mixing of different blocks, depending on composition and topology.
Polymeric assembly of endogenous Tuberous Sclerosis Protein Complex (2021)

Abstract Tuberous Sclerosis protein complex (pTSC) nucleates a proteinaceous signaling hub that integrates information about the internal and external energy status of the cell in regulation of growth and energy consumption. Biochemical and electron cryomicroscopy (cryoEM) studies of recombinant pTSC have revealed the structure and stoichiometry of the pTSC and have hinted at the possibility that the complex form large oligomers. Here, we have partially purified endogenous pTSC from fasted mammalian brains of rat and pig by leveraging a recombinant antigen binding fragment (F ab ) specific for the TSC2 subunit of pTSC. We demonstrate F ab dependent purification of pTSC from membrane solubilized fractions of the brain homogenates. Negative stain electron microscopy of the samples purified from pig brain demonstrates rod-shaped protein particles with a width of 10 nm, a variable length as small as 40 nm and a high degree of conformational flexibility. Larger filaments are evident with a similar 10 nm width and up to 1 μm in length in linear and web-like organizations prepared from pig brain. These observations suggest polymerization of endogenous pTSC into filamentous super-structures.
Activation volume for boron diffusion in silicon and implications for strained films (1999)

The diffusivity of B in Si is enhanced by pressure, characterized by an activation volume of V*=−0.17±0.01 times the atomic volume; V* is close to the formation volume of the self-interstitial determined by atomistic calculations. The results for hydrostatic pressure are used to make predictions for the effect of biaxial strain on diffusion. Assuming an interstitial-based mechanism and a range of values for the anisotropy in the migration volume, comparison is made between our results, the atomistic calculations, and the measured dependence of B diffusion on biaxial strain. We find a qualitative consistency for an interstitial-based mechanism with the measured strain effect on diffusion in Si–Ge alloys, but not with the measured strain effect in pure Si. Experiments and calculations to determine the origin of this discrepancy are discussed.
Model of energetic electron transport in magnetron discharges (1990)

A particle model of energetic electron transport in sputtering magnetron discharges is presented. The model assumes time-independent magnetic and electric fields and supposes that scattering by neutral atoms is the dominant transport mechanism. Without scattering, we find that some orbits are confined indefinitely. Using the differential cross sections for elastic, excitation, and ionization collisions in argon, we perform a Monte Carlo simulation of the electrons emitted by ion bombardment of a planar magnetron cathode to predict the spatial distribution of ionization. We find good agreement with experimental measurements of the radial profile of ion flux to the cathode and of the axial profile of optical emission.
Information Retrieval with Time Series Query (2013)

We study a novel information retrieval problem, where the query is a time series for a given time period, and the retrieval task is to find relevant documents in a text collection of the same time period, which contain topics that are correlated with the query time series. This retrieval problem arises in many text mining applications where there is a need to analyze text data in order to discover potentially causal topics. To solve this problem, we propose and study multiple retrieval algorithms that use the general idea of ranking text documents based on how well their terms are correlated with the query time series. Experiment results show that the proposed retrieval algorithm can effectively help users find documents that are relevant to the time series queries, which can help users analyze the variation patterns of the time series.
A multiplexed, low cost, cellphone-based system for Ebola and Marburg disease surveillance (2020)

Background: The aim of the study is to develop a low cost system for studying antibody responses to Ebola and Marburg infection for surveillance purposes. There are no serological assays that are available in common clinical practice for detection of filovirus antibody responses. Most experimental methods are capable of only measuring antibodies against one or two of the five species of Ebola and Marburg viruses that cause human disease. The developed system included a flow cell assay cartridge that captures specific antibodies with microarrayed recombinant antigens from all six species of filovirus, and a cellphone-based fluorescent reader for high-performance interpretation of test results. Methods and materials: The first phase of the project focused on the development a prototype flow cell cartridge containing Glycoproteins and Nucleoproteins from all six species of filovirus family arrayed on a nitrocellulose coated membrane. An opto-electro-mechanical hardware attachment that snaps at the back of a Motorola Nexus cellphone provided the user interface to manage the operation. The App acquired the test results and communicated with cloud service to report results remotely. The App also controlled the hardware attachment to turn on LEDs and digitally record the optically enhanced images. Results: The prototype system was validated with sera from non-human primates that received a live attenuated EBOV vaccine. The system clearly distinguished between sera that contained anti-EBOV antibodies and non-vaccinated controls. The second phase of the project improved on the prototype system and consists of a sealed single use assay cartridge, and a reader that designed to work with most cellphones through an App. The cartridge features plasma separation from a drop of blood, storage of heat-stable on-board dried secondary reagent, a mixing pathway, and a fluorescent signal chamber where the capture antigens are printed. The independent reader setup utilizes a dedicated imaging sensor for better control and transmits the image to cellphone through Bluetooth for user interface and data analysis. Conclusion: This disease-telemonitoring system will be useful in the laboratory analysis of recent or active infections, and may prevent the rapid overwhelming of medical systems and resources during EVD or MVD outbreaks.
Fungal electronics (2021)

Fungal electronics is a family of living electronic devices made of mycelium bound composites or pure mycelium. Fungal electronic devices are capable of changing their impedance and generating spikes of electrical potential in response to external control parameters. Fungal electronics can be embedded into fungal materials and wearables or used as stand alone sensing and computing devices.
Metastatic disease to the breast: the Washington University experience (2007)

Due to the variable course of patients with metastatic disease, a multi-disciplinary approach is necessary for each patient with disease metastatic to the breast to determine optimal treatment. Based on our review, many patients survive for long periods of time and local treatment of metastases to the breast may be beneficial in these patients to prevent local complications.
Corticotropin-Releasing Hormone: Clinical Applications (1989)

Corticotropin-releasing hormone, a 41-amino-acid peptide, is an important hypothalamic factor regulating the pituitary secretion of adrenocorticotropic hormone (ACTH). This hormone, while rarely involved in the etiology of Cushing's syndrome, seems to play a major role in the pathogenesis of non-Cushing hypercortisolemic states. The administration of synthetic human and ovine CRH has been found useful in the differential diagnosis of Cushing's syndrome and in the preoperative localization of intrasellar ACTH-secreting tumors.
Faraday Rotation Probe of Laser-Plasma Bubble Structures in Petawatt-Driven Wakes (2017)

We exploited the Faraday effect to imprint polarization shifts on a transverse probe that captured the structure of a GeV laser-plasma accelerator. Our measurements suggested a plasma bubble diameter ≈ 50.8±10.1 μm.
Deep 3D Capture: Geometry and Reflectance From Sparse Multi-View Images (2020)

We introduce a novel learning-based method to reconstruct the high-quality geometry and complex, spatially-varying BRDF of an arbitrary object from a sparse set of only six images captured by wide-baseline cameras under collocated point lighting. We first estimate per-view depth maps using a deep multi-view stereo network; these depth maps are used to coarsely align the different views. We propose a novel multi-view reflectance estimation network architecture that is trained to pool features from these coarsely aligned images and predict per-view spatially-varying diffuse albedo, surface normals, specular roughness and specular albedo. We do this by jointly optimizing the latent space of our multi-view reflectance network to minimize the photometric error between images rendered with our predictions and the input images. While previous state-of-the-art methods fail on such sparse acquisition setups, we demonstrate, via extensive experiments on synthetic and real data, that our method produces high-quality reconstructions that can be used to render photorealistic images.
March Test BDN: A new March Test for dynamic faults (2008)

High-density components and process scaling lead more and more to the occurrence of new class of dynamic faults, especially in Static Random Access Memories (SRAMs), thus requiring more and more sophisticated test algorithms. Among the different types of algorithms proposed for testing SRAMs, March Tests have proven to be the most performing due to their low complexity, their simplicity and regular structure. Several March Tests for dynamic faults have been published, with different fault coverage. In this paper we propose March BDN, an extended version of the March AB. We will prove that it is able to increase the fault coverage in order to target latest dynamic faults. We show that the proposed March BDN has the highest known fault coverage compared to March Tests with the same complexity.
FLUTE: Fast and Secure Lookup Table Evaluations (2023)

The concept of using Lookup Tables (LUTs) instead of Boolean circuits is well-known and been widely applied in a variety of applications, including FPGAs, image processing, and database management systems. In cryptography, using such LUTs instead of conventional gates like AND and XOR results in more compact circuits and has been shown to substantially improve online performance when evaluated with secure multi-party computation. Several recent works on secure floating-point computations and privacy-preserving machine learning inference rely heavily on existing LUT techniques. However, they suffer from either large overhead in the setup phase or subpar online performance.We propose FLUTE, a novel protocol for secure LUT evaluation with good setup and online performance. In a two-party setting, we show that FLUTE matches or even outperforms the online performance of all prior approaches, while being competitive in terms of overall performance with the best prior LUT protocols. In addition, we provide an open-source implementation of FLUTE written in the Rust programming language, and implementations of the Boolean secure two-party computation protocols of ABY2.0 and silent OT. We find that FLUTE outperforms the state of the art by two orders of magnitude in the online phase while retaining similar overall communication.
ChemInform Abstract: Biotin Biosynthesis: Synthesis and Biological Evaluation of the Putative Intermediate Thiols. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 5607: TLE4 is a key modulator of resistance to mTOR pathway specific inhibition in glioblastoma (2012)

Abstract Rapamycin, a selective inhibitor of TOR (target of rapamycin), has been used in clinical trials for the treatment of glioma (Cloughesy et al., 2008). However, even though some patients respond temporarily to rapamycin treatment, virtually all recur. The mechanisms underlying this resistance to therapy are unknown. Here, we utilized patient-derived glioblastoma (GBM) neurosphere cultures to examine these mechanisms. GBM cell cultures exposed to chronic rapamycin yield a population of rapamycin resistant cells with an increased malignant phenotype upon removal from treatment, enhanced sphere formation in vitro and enhanced tumorigenesis. We used an unbiased, proteomics-based approach to discover phosphopeptides that were upregulated during rapamycin treatment in vitro. Amongst the peptides that we uncovered was Tle4/Groucho, a global co-repressor and known modulator of several key signaling pathways, including the Wnt and Notch pathways. In an expression microarray, Tle4 was found to be significantly upregulated within chronic rapa treated GBM cells. We show that TLE4 is a key modulator of resistance to mammalian target of rapamycin (mTOR) pathway specific inhibition. While TLE4 knockdown has no clear effect on naive cells, this knockdown promotes sensitivity under chronic rapamycin treatment as evidenced by reduced neurosphere formation. TLE4 mediate rapamycin resistance through activation of the quiescent population. Our results indicate that chronic mTOR specific inhibition imparts TLE4 mediated resistance through both ERK activation and inhibition of mTOR. The identification of this role for TLE4 in rapamycin resistance provides a novel target for mTOR pathway-associated chemotherapeutic agents. References: Cloughesy, T.F., Yoshimoto, K., Nghiemphu, P., Brown, K., Dang, J., Zhu, S., Hsueh, T., Chen, Y., Wang, W., Youngkin, D., et al. (2008). Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med 5, e8. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 5607. doi:1538-7445.AM2012-5607