gebhart/patrepeval huggingface dataset:
Gemcitabine as a single agent in the treatment of relapsed or refractory low‐grade non‐Hodgkin's lymphoma (2001)

A multicentre phase II trial was conducted to evaluate the efficacy and toxicity of gemcitabine in patients with refractory or relapsed indolent non-Hodgkin's lymphoma. Thirty-six patients were enrolled onto the study, including 11 cases of mantle cell lymphoma (MCL), 10 cases of chronic lymphocytic leukaemia (CLL)/lymphocytic lymphoma, nine cases of follicular lymphoma, four cases of lymphoplasmacytic lymphoma and two cases of T-cell lymphoma. Gemcitabine 1 g/m(2) was administered as a 30-min infusion on d 1, 8 and 15 of a 28-d schedule, up to a maximum of six cycles. Complete responses were observed in two patients with MCL, and partial responses were observed in seven patients, including three patients with CLL/lymphocytic lymphoma, two patients with T-cell lymphoma, one patient with MCL and one patient with follicular lymphoma. Minor responses were observed in three patients, including two patients with MCL and one patient with CLL. The median duration of response was 150 d and the overall progression-free survival was 342 d. Haematological toxicity was observed as grade 3-4 leucopenia in 12 patients (33%) and grade 3-4 thrombocytopenia in 18 patients (50%). Severe non-haematological toxicity included one case of fatal veno-occlusive disease, one case of thrombotic microangiopathy leading to terminal renal failure, one case of capillary leak syndrome, one case of myocardial infarction and drug-induced fever in two patients. These data suggest that gemcitabine displays activity in patients with MCL and CLL/lymphocytic lymphoma. Haematological toxicity was frequent in these heavily treated patients. Severe non-haematological toxicity was significant and should be taken into account in the design of future trials.
Search for top squarks in final states with one isolated lepton, jets, and missing transverse momentum in collisions with the ATLAS detector (2016)

The results of a search for the top squark, the supersymmetric partner of the top quark, in final states&#13;\nwith one isolated electron or muon, jets, and missing transverse momentum are reported. The search&#13;\nuses the 2015 LHC pp collision data at a center-of-mass energy of ffiffi&#13;\ns p ¼ 13 TeV recorded by the&#13;\nATLAS detector and corresponding to an integrated luminosity of 3.2 fb−1. The analysis targets two&#13;\ntypes of signal models: gluino-mediated pair production of top squarks with a nearly mass-degenerate&#13;\ntop squark and neutralino and direct pair production of top squarks, decaying to the top quark and the&#13;\nlightest neutralino. The experimental signature in both signal scenarios is similar to that of a top quark&#13;\npair produced in association with large missing transverse momentum. No significant excess over the&#13;\nStandard Model background prediction is observed, and exclusion limits on gluino and top squark&#13;\nmasses are set at 95% confidence level. The results extend the LHC run-1 exclusion limit on the gluino&#13;\nmass up to 1460 GeV in the gluino-mediated scenario in the high gluino and low top squark mass region&#13;\nand add an excluded top squark mass region from 745 to 780 GeV for the direct top squark model with a&#13;\nmassless lightest neutralino. The results are also reinterpreted to set exclusion limits in a model of&#13;\nvectorlike top quarks.
Iterative Design of Gestures during Elicitation: A Gateway into User's Mental Models. (2021)

The design of gestural interfaces through gesture elicitation studies is influenced by legacy bias, wherein users will draw from touch and desktop interactions when specifying gestures for novel interactions, such as full-body and free-space applications. This may inhibit users from developing gestures that are more appropriate and less fatiguing for the interaction. Increasing production during elicitation studies has shown promising results in moving users beyond legacy biased gestures. However, when increasing production, users begin to iterate on their gestures. In this paper, we present a gesture elicitation methodology aimed at understanding design iteration in studies that use increased production. We show that gestural refinements provide insight into the gestural features that matter for users to assign semantic meaning and discuss implications for training gesture classifiers. We also discuss a potential relationship between refined features and fatigue, showing that refinements may map to less fatiguing gestures.
30-GHz High-Frequency Application of Screen Printed Interconnects on an Organic Substrate (2017)

Printed conductive traces on flexible substrates offer many potential applications in the area of wearable electronics, ranging from search and rescue operations to health and physiological monitoring. The literature abounds on the effect of sintering conditions on the dc electrical resistivity of printed traces, due to the applications considered which fall in the lower frequency domain (megahertz range). There is a growing interest to investigate wireless body area networks for wearable electronics operating in the higher frequencies, due to the advantages involved. At present, there is a little information available on the radio frequency performance of printed interconnects, and this work seeks to investigate the effect of the paste property on the dc conductivity and high-frequency performance (≤30 GHz) of interconnects. The results obtained suggest that paste leveling has a significant influence on the dc electrical performance. In addition, the dc conductivity values are possibly affected by the adhesion of the paste onto the particular substrate during the printing process, which was observed to have a significant effect on the quality and thicknesses of the traces printed. Last, the influence of the dc conductivity on the high-frequency performance of interconnects is investigated, where the measured results are validated with simulation results.
Wind Resistance of Vented Vinyl and Aluminum Soffit Panel Systems (2013)

This paper addresses the wind load resistance of straight and corner sections of aluminum and vinyl vented soffits. Multiple post-storm damage assessments have documented their failure on low-rise buildings. This study used a pressure loading actuator system to apply quasi-static (ramp) and dynamic wind loading derived from wind tunnel measurements to conventional soffit systems in order to determine failure pressures. The results indicate that shorter overhangs are expected to perform well, even in very severe tropical cyclones. However, longer overhang soffits fail at significantly lower pressures. Corner sections appear to be more susceptible to wind loading than straight sections; additional guidance regarding installation (especially for corner installations) and product approval is warranted.
P933: DARATUMUMAB (D) IN COMBINATION WITH VD OR D-RD IN RELAPSED OR REFRACTORY MULTIPLE MYELOMA: SUBGROUP ANALYSIS OF CASTOR AND POLLUX STUDIES IN PATIENTS WITH EARLY OR LATE RELAPSE AFTER INITIAL THERAPY (2022)

Background: High-risk multiple myeloma (MM) is often defined based on cytogenetic abnormalities (ie, t[4;14], t[14;16], and/or del17p); however, patients who relapse early (12-18 months) after initial therapy are considered a functional high-risk group that is also associated with poor prognosis. Daratumumab (DARA), a human IgGk monoclonal antibody targeting CD38, is approved in combination with standard-of-care regimens for MM. In the phase 3 CASTOR and POLLUX studies, DARA in combination with bortezomib plus dexamethasone (D-Vd) and lenalidomide plus dexamethasone (D-Rd) significantly improved progression-free survival (PFS), regardless of cytogenetic risk, and achieved higher rates of complete response or better (≥CR) and minimal residual disease (MRD)–negativity vs Vd or Rd alone in patients with RRMM. Aims: In this post-hoc analyses of CASTOR and POLLUX we evaluated D-Vd vs Vd and D-Rd vs Rd in patient subgroups with 1 prior line of therapy based on timing of relapse (early or late) after initiation of the first line of therapy. Methods: In CASTOR and POLLUX, patients with RRMM and ≥1 prior line of therapy were randomized to D-Vd/Vd or D-Rd/Rd, respectively. The primary endpoint was PFS. In this analysis, the early relapse subgroup included patients with 1 prior line of therapy who relapsed <18 months after initiating their first line of therapy; patients with 1 prior line of therapy who relapsed ≥18 months after initiating their first line of therapy were included in the late relapse subgroup. Results: 49 and 186 patients from CASTOR and 99 and 196 patients from POLLUX were included in the early relapse and late relapse subgroups, respectively. Median follow-up was 72.6 months (CASTOR) and 79.7 months (POLLUX). PFS consistently favored the DARA-containing regimens across subgroups (Table). In CASTOR, ≥CR rates were higher with D-Vd vs Vd in the early relapse (21% vs 17%; P = 0.7360) and late relapse (51% vs 14%; P <0.0001) subgroups. In POLLUX, ≥CR rates were higher with D-Rd vs Rd in the early relapse (53% vs 12%; P <0.0001) and late relapse (62% vs 38%; P = 0.0012) subgroups. MRD-negativity rates (10–5) were higher with D-Vd/D-Rd vs Vd/Rd regardless of relapse timing (CASTOR: early, 13% vs 0%; P = 0.1476; late, 23% vs 3%; P <0.0001; POLLUX: early, 30% vs 4%; P = 0.0006; late, 34% vs 14%; P = 0.0009). Image:Summary/Conclusion: These post hoc analyses of CASTOR and POLLUX showed PFS and depth of response benefits of DARA-containing regimens in patients with 1 prior line of therapy, regardless of relapse timing (early or late). Our results support the use of D-Vd and D-Rd in RRMM, including in patients who are considered functional high risk.
Cord Metabolic Profiles in Obese Pregnant Women: Insights Into Offspring Growth and Body Composition (2017)

Concentrations of LPCs and IGF-1 in cord blood are related to infant weight. These findings support the hypothesis that susceptibility to childhood obesity may be programmed in utero, but further investigation is required to establish whether these associations are causally related.
Low Bias Low Variance Gradient Estimates for Boolean Stochastic Networks (2020)

Stochastic neural networks with discrete random variables are an important class of models for their expressiveness and interpretability. Since direct differentiation and backpropagation is not possible, Monte Carlo gradient estimation techniques are a popular alternative. Efficient stochastic gradient estimators, such Straight-Through and Gumbel-Softmax, work well for shallow stochastic models. Their performance, however, suffers with hierarchical, more complex models. We focus on stochastic networks with Boolean latent variables. To analyze such networks, we introduce the framework of harmonic analysis for Boolean functions to derive an analytic formulation for the bias and variance in the Straight-Through estimator. Exploiting these formulations, we propose \\emph{FouST}, a low-bias and low-variance gradient estimation algorithm that is just as efficient. Extensive experiments show that FouST performs favorably compared to state-of-the-art biased estimators and is much faster than unbiased ones.
Fabrication of implantable microelectrode arrays by laser cutting of silicone rubber and platinum foil (2005)

A new method for fabrication of microelectrode arrays comprised of traditional implant materials is presented. The main construction principle is the use of spun-on medical grade silicone rubber as insulating substrate material and platinum foil as conductor (tracks, pads and electrodes). The silicone rubber and the platinum foil are patterned by laser cutting using an Nd:YAG laser and a microcontroller-driven, stepper-motor operated x-y table. The method does not require expensive clean room facilities and offers an extremely short design-to-prototype time of below 1 day. First prototypes demonstrate a minimal achievable feature size of about 30 microm.
Multi-level ant colony algorithm for optimal placement of capacitors in distribution systems (2005)

An ant colony algorithm is proposed to determine the optimal locations and ratings of capacitors in a distribution network for reactive power compensation. The approach is multilevel. Two separate tables of pheromones are maintained by the algorithm. Ants generate solution stochastically, based on these pheromone tables. The pheromone tables are updated periodically, so that pheromones accrue more along better solutions. Results obtained by the proposed algorithm have been compared with earlier schemes. We conclude that the proposed approach is an effective approach for optimally placing capacitors in a distribution system.
Near-Optimal Nonmyopic Contact Center Planning Using Dual Decomposition (2014)

We address the problem of minimizing staffing cost in a contact center subject to service level requirements over multiple weeks. We handle both the capacity planning and agent schedule generation aspect of this problem. Our work incorporates two unique business requirements. First, we develop techniques that can provide near-optimal staffing for 247 contact centers over long term, upto eight weeks, rather than planning myopically on a week-on-week basis. Second, our approach is usable in an online interactive setting in which staffing managers using our system expect high quality plans within a short time period. Results on large real world and synthetic instances show that our Lagrangian relaxation based technique can achieve a solution within 94% of optimal on an average, for eight week problems within ten minutes, whereas a generic integer programming solver can only achieve a solution within 80% of optimal. Our approach is also deployed in live business environment and reduces headcount by a decile over techniques used previously by our client business units.
A method to determine the ability of drugs to diffuse through the blood-brain barrier. (1994)

A method has been devised for predicting the ability of drugs to cross the blood-brain barrier. The criteria depend on the amphiphilic properties of a drug as reflected in its surface activity. The assessment was made with various drugs that either penetrate or do not penetrate the blood-brain barrier. The surface activity of these drugs was quantified by their Gibbs adsorption isotherms in terms of three parameters: (i) the onset of surface activity, (ii) the critical micelle concentration, and (iii) the surface area requirement of the drug at the air/water interface. A calibration diagram is proposed in which the critical micelle concentration is plotted against the concentration required for the onset of surface activity. Three different regions are easily distinguished in this diagram: a region of very hydrophobic drugs which fail to enter the central nervous system because they remain adsorbed to the membrane, a central area of less hydrophobic drugs which can cross the blood-brain barrier, and a region of relatively hydrophilic drugs which do not cross the blood-brain barrier unless applied at high concentrations. This diagram can be used to predict reliably the central nervous system permeability of an unknown compound from a simple measurement of its Gibbs adsorption isotherm.
Resistin Promotes Smooth Muscle Cell Proliferation Through Activation of Extracellular Signal–Regulated Kinase 1/2 and Phosphatidylinositol 3-Kinase Pathways (2004)

Our results demonstrate that resistin induces HASMC proliferation through both ERK 1/2 and Akt signaling pathways. The proliferative action exerted by resistin on HASMCs may account in part for the increased incidence of restenosis in diabetes patients.
Learning precise 3D reaching in a humanoid robot (2007)

In this paper we discuss the implementation of a precise reaching controller on an upper-torso humanoid robot. The proposed solution is based on a learning strategy which does not rely on a priori models of the kinematics of the arm nor of that of the head. After learning, the robot can reach for visually identified objects in 3-D space by integrating an open loop and a closed loop component; the open loop controller allows ballistic movements, while the closed loop one performs precise positioning of the hand in visual space. Differently from other approaches we handle the critical case of redundancy in the head and the arm and propose a solution that although preliminary possesses some biological relevance.
Supplementary Table 1 from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt; (2023)

Supplementary Table 1 from (3-Chloroacetyl)-indole, a Novel Allosteric AKT Inhibitor, Suppresses Colon Cancer Growth &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;
Growth of 3C-SiC Films on Si (111) and Sapphire (0001) Substrates by MOCVD (2013)

Thick silicon carbide films were grown on sapphire (0001) and silicon (111) substrates using metal organic chemical vapor deposition (MOCVD). Diethylmethylsilane (DEMS) has been used as a single precursor, which contain Si and C atoms in the same molecule, without any carrier or bubbler gas. Atomic structure, surface composition and morphology have been investigated by XRD, AES, SEM and AFM analysis. SiC films of 5-7 micron thickness were grown at a rate of ~ 40 nm/min on sapphire (0001) and Si (111) substrates. The films grown at low temperature (850 ºC and 900 ºC) on both substrates show crystalline 3C-SiC in the (111) orientation. XRD results show that the orientation of the crystal structure does not depend of the substrate orientation AFM pictures of SiC films grown on sapphire (0001) exhibit more crystalline order as compared to films grown on the Si (111) substrates. AES of the grown films shows that in both cases the Si peak intensity is greater than that of carbon. This work shows promise for the development of alternative processes for developing low cost, large area substrates for application to IIInitrides LED and UV photodetector fabrication and also for gas detector application.
A bound on null functions for digital imaging systems with positivity constraints (1997)

There is an upper bound for the L(1) norm of the difference of two nonnegative object functions when they both produce the same data in a digital imaging system. This bound is achieved for a certain class of systems and an arbitrary nonnegative object. For the L(2) norm of the difference, with the same conditions on the object functions, there is no upper bound.
Comparison of robust to standardized CT radiomics models to predict overall survival for non‐small cell lung cancer patients (2020)

Prognostic OS CT radiomics model for NSCLC based on a heterogeneous multicentric imaging dataset with robust feature pre-selection performed equally well as a model on a standardized dataset.
Next generation 650V CSTBT&lt;sup&gt;TM&lt;/sup&gt; with improved SOA fabricated by an advanced thin wafer technology (2015)

Using an advanced thin wafer technology, we have successfully fabricated the next generation 650V class IGBT with an improved SOA and maintaining the narrow distribution of the electrical characteristics for industrial applications. The applied techniques were the finer pattern transistor cell, the thin wafer process and the optimized back side doping concentration profiles. With the well organized back-side wafer process, the practically large chip has achieved without any sacrifice of the production yield. As a results, V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CEsat</sub> -E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">off</sub> trade-off relationship and an Energy of Short Circuit by active Area (E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">SC</sub> /A) are improved in comparison with the conventional Punch Through (PT) structure.
Adaptive memory-side last-level GPU caching (2019)

Emerging GPU applications exhibit increasingly high computation demands which has led GPU manufacturers to build GPUs with an increasingly large number of streaming multiprocessors (SMs). Providing data to the SMs at high bandwidth puts significant pressure on the memory hierarchy and the Network-on-Chip (NoC). Current GPUs typically partition the memory-side last-level cache (LLC) in equally-sized slices that are shared by all SMs. Although a shared LLC typically results in a lower miss rate, we find that for workloads with high degrees of data sharing across SMs, a private LLC leads to a significant performance advantage because of increased bandwidth to replicated cache lines across different LLC slices.
Modeling Uncertainty by Learning a Hierarchy of Deep Neural Connections (2019)

Modeling uncertainty in deep neural networks, despite recent important advances, is still an open problem. Bayesian neural networks are a powerful solution, where the prior over network weights is a design choice, often a normal distribution or other distribution encouraging sparsity. However, this prior is agnostic to the generative process of the input data, which might lead to unwarranted generalization for out-of-distribution tested data. We suggest the presence of a confounder for the relation between the input data and the discriminative function given the target label. We propose an approach for modeling this confounder by sharing neural connectivity patterns between the generative and discriminative networks. This approach leads to a new deep architecture, where networks are sampled from the posterior of local causal structures, and coupled into a compact hierarchy. We demonstrate that sampling networks from this hierarchy, proportionally to their posterior, is efficient and enables estimating various types of uncertainties. Empirical evaluations of our method demonstrate significant improvement compared to state-of-the-art calibration and out-of-distribution detection methods.
Using ARToolkit for passive tracking and presentation in ubiquitous workspaces (2004)

This paper presents new infrastructure for future work environments. These environments support a variety of display and interaction modalities for use by multiple users. To be able to interact in such environments, a mechanism must exist to track devices, displays, etc. We present a passive detection framework that uses ARToolkit and fiducial markers to track marked objects in a workspace. To solve for occlusion of targets, we propose the use of multiple cameras monitoring a work environment form multiple angles. A key advantage of this approach is that it allows the tracking cards to be used for both control and display of ambient information.