gebhart/patrepeval huggingface dataset:
Effects of Hydrogen Bonding and Structure of the Accessory Bacteriochlorophylls on Charge Separation in <i>Rb. capsulatus</i> Reaction Centers (2004)

Histidine residues have been introduced into Rb. capsulatus reaction centers at M-polypeptide position 201 and at L-polypeptide position 174 to engender hydrogen bonds to the ring-V keto groups of the accessory bacteriochlorophyll cofactors BA and BB, respectively. Resonance Raman studies indicate that both mutations result in hydrogen-bonding interactions, as well as significant perturbations to the structure of the bacteriochlorophyll macrocycles. Nonetheless, ultrafast transient absorption measurements show that the structural/energetic effects of the mutations cause only minor changes in the primary photochemistry.
Stretchable electronics for ubiquitous physiological monitoring (2021)

While great advances in medicine has been made in the past century, the overall infrastructure of the healthcare system has not progressed. Patients (who are not feeling well) are still expected to travel to a centralized location for discrete, reactionary-based care where the healthcare provider only has a brief window to assess the patient’s health. Unless the symptoms are overt at the time of examination, the subjective evaluation relies heavily on the self-reporting of symptoms from the patient. This often results in delayed or improper diagnoses. In contrast, we know that physiological signals precede clinical deterioration. We have developed a suite of low-cost, unobtrusive, Band-Aid©-like physiological sensors to continuously monitor patients’ cardiovascular and pulmonary functions. We seek to continuously quantify subtle physiological changes to predict, and eventually prevent, the onset of acute clinical events.
Leap-Frog Continuous–Discontinuous Galerkin Time Domain Method for Nanoarchitectures With the Drude Model (2017)

A continuous-discontinuous Gakerkin time domain method (CDGTD) with vector basis functions is proposed to analyze the wideband response of plasmonic structures with the Drude dispersive model. Compared to the conventional time domain approaches, such as FDTD and PSTD, the unstructured mesh can provide a better geometrical approximation of curved surfaces and fine features. An EB scheme Riemann solver is employed to calculate the flux between adjacent subdomains. The relationship between the electric field and the polarization currents is modeled by a first order auxiliary differential equation (ADE). A leap-frog scheme is proposed to update Maxwell's equations, the ADEs of the Drude medium and the perfectly matched layer (PML) in an efficient manner. This new approach is validated by virtue of simulating the ultra-wideband behavior of a gold nanoloop antenna with and without a substrate as well as the reflectivity of a dual-band infrared absorber. Its advantage in computational cost is demonstrated via comparison to a commercial software package. In this light, the CDGTD method represents a more efficient forward modeling tool, which has been successfully employed here to perform a parametric study of a dual-band infrared absorber.
Estimation of Corn and Soybeans Yields of the US Midwest using Satellite Imagery and Climate Dataset (2014)

This paper described the estimation of corn and soybeans yields of four states in the US Midwest using time-series satellite imagery and climate dataset between 2001 and 2012. We first constructed a database for (1) satellite imagery acquired from Terra MODIS (Moderate Resolution Imaging Spectroradiometer) including NDVI (Normalized Difference Vegetation Index), EVI (Enhanced Vegetation Index), LAI (Leaf Area Index), FPAR (Fraction of Photosynthetically Active Radiation), and GPP (Gross Primary Productivity), (2) climate dataset created by PRISM (Parameter-Elevation Regressions on Independent Slopes Model) such as precipitation and mean temperature, and (3) US yield statistics of corn and soybeans. Then we built OLS (Ordinary Least Squares) regression models for corn and soybeans yields between 2001 and 2010 after correlation analyses and multicollinearity tests. These regression models were used in estimating the yields of 2011 and 2012. Comparisons with the US yield statistics showed the RMSEs (Root Mean Squared Errors) of 0.892 ton/ha and 1.095 ton/ha for corn yields in 2011 and 2012 respectively, and those of 0.320 ton/ha and 0.391 ton/ha for soybeans yields. This result can be thought of as a good agreement with the in-situ statistics because the RMSEs were approximately 10% of the usual yields: 9 ton/ha for corn and 3 ton/ha for soybeans. Our approach presented a possibility for extending to more advanced statistical modeling of crop yields using satellite imagery and climate dataset.
Active opacity of discrete-event systems (2022)

As an essential attribute of information flow, opacity is used to characterise whether or not the intruders can infer the system secrets, which has caused considerable concern. For a complex system with multiple secret states, it is difficult to ensure the system opacity, which makes it necessary to actively control the system to enforce their opacity. In this regard, based on the framework of partially observable and controllable discrete event system, the active current-state opacity is studied. The system being actively opaque means that we can find a control for each secret state such that the behaviour of system reaching the secret state is opaque. Under such control, the intruder is unable to confirm the current state as secret state through limited observation. We construct an active-opacity verifier and derive a necessary and sufficient condition to check the active opacity of the system.
EN3427 (2015)

The present studies demonstrate that a new molecular entity, EN3427, produces effective and long-lasting analgesia in 2 rodent pain models. The analgesic effects of EN3427 are significantly longer-lasting than lidocaine and are further extended when EN3427 is combined with lidocaine. The results are discussed with respect to a possible lidocaine-mediated TRP channel activation and facilitated neuronal access of EN3427, with subsequent entrapment conferring extended-duration efficacy.
Various approaches for the treatment of acute aortic dissection type A (2004)

Objectives: To compare the outcome of three different approaches to replace the dissected ascending aorta including the valve preserving reimplantation technique.
Complexation of 6-ACYL-O-β-Cyclodextrin derivatives with steroids - effects of chain length and substitution degree (1992)

This study was designed to test a hypothesis that the esterification of the primary 6-hydroxyl groups on β-cyclodextrin (β-CD) may disrupt its crystallinity, thereby enhancing its aqueous solubility and increasing its ability to solubilize water-insoluble compounds. 6-acyl-o-β-CD derivatives with different chain length and substitution degree were synthesized by esterifying the primary hydroxyl groups at 6-position of β-CD with various acyl chlorides. X-ray diffraction patterns confirmed the existence of 6-acyl-o-β-CD derivatives as amorphous solid. Effects of chain length and substitution degree of the acyl groups on 6-acyl-o-β-CD/steroid complexation and solubilization were investigated with the phase solubility method. The results indicated that the solubilities of 6-acyl-o-β-CD derivatives were significantly higher than that of β-CD itself, which resulted in an increase in their ability to solubilize poorly water-soluble drugs such as steroids. The addition of side chains to β-CD did not change the stoichiometric ratio (2:1) of β-CD/steroid complexes. The increase in chain length can enhance the association of 6-acyl-o-β-CDs with steroids as it was evidenced from the apparent stability constants. A solubility study utilizing different combinations of 6-acyl-o-β-CDs, α-CD and 2,6- dimethyl-o-β-CD suggested a competitive complexation process among the family of acyl-β-CD derivatives. A non-competitive steroid complexation between 6-acyl-o-β-CDs and α-CD and between 6-acyl-o-β-CDs and 2,6-dimethyl-o-β-CD was observed.
High‐Performance Broadband Tungsten Disulfide Photodetector Decorated with Indium Arsenide Nanoislands (2020)

The 2D tungsten disulfide (WS 2 ), as a typical transition metal dichalcogenide (TMD), has aroused intense research interests in photodetection. However, the limited detection wavelength ranges and low photoresponsivity hinder its further application. To promote the application of WS 2 in optoelectronics fields, indium arsenide (InAs) nanoislands decorated WS 2 are utilized to fabricate photodetectors in this work. Owing to the photogating effect and localized surface plasmon resonance (LSPR), a significant enhancement of photocurrent response (≈1 mA W −1 ) is obtained by coupling WS 2 with InAs nanoislands. Furthermore, the extended detection wavelength up to 1060 nm is realized due to the efficient light absorption in IR range of InAs nanoislands. The high performance, stability, and reliability in ambient temperature strongly indicate that the InAs nanoislands/WS 2 heterostructure can be considered as a promising material for TMDs‐based broadband optoelectronic devices in the future.
Transmural Distribution of Three-Dimensional Systolic Strains in Stunned Myocardium (2001)

Myocardial ischemia/reperfusion in the dog results in a significant transmural gradient of dysfunction between epicardial and endocardial layers in radial and cross-fiber segments, but not for fiber segments, despite a gradient in blood flow reduction during ischemia. Perhaps systolic fiber dysfunction rather than the degree of perfusion deficit during the preceding ischemic period may be the main determinant of myocardial dysfunction during reperfusion.
Quantitative Acoustic Microscopy Based on the Array Approach (2013)

This chapter considers the application of ultrasonic arrays for measurement of the velocity and attenuation of the leaky surface wave and for simultaneous measurement of the bulk wave velocity and the thickness of the plate specimen. In the leaky surface acoustic wave (LSAW) measurement the tilted transducer is usually used for effective generation of the leaky waves since their critical angles are relatively large. For measurement of the bulk wave velocities and the thickness of the plate specimen the incident angles of the probing and reflected waves are relatively small. In comparison with the existing quantitative acoustic microscopy method, mechanical scanning of the transducers is no longer used in the considered technique, and the measurement time is only limited by the time of wave propagation and the speed of the electronic data acquisition system. Controlled Vocabulary Terms acoustic microscopy; acoustic wave propagation; acoustic wave velocity; data acquisition; surface acoustic wave devices; ultrasonic arrays
Proceedings of the 36th annual meeting on Association for Computational Linguistics - (1998)

This volume is the official record of the proceedings of the 19th Annual Meeting of the Association for Computational Linguistics, held on the campus of Stanford University, from June 29 to July 1, 1981. It contains both the refereed papers presented at the meeting and the position statements of the participants to the two invited panels, the first on the evaluation of natural language interfaces to databases, and the second on parsing.
Direct Propargylation of Furan and Arene by Propargylic Alcohols Promoted by Bisoxazoline—Ruthenium Catalysts. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Conversion of d-penicillaminato trinuclear to mononuclear palladium(ii) structure by diamine ligands: remarkable enantioselectivity toward racemic 1,2-cyclohexanediamine (2012)

The reactions of an S-bridged trinuclear palladium(II) complex, [Pd(3)(D-pen-N,O,S)(3)] (D-H(2)pen = D-penicillamine), with ethylenediamine (en) and racemic (R,R/S,S) 1,2-cyclohexanediamine (chxn) in water gave mononuclear palladium(II) complexes, [Pd(D-pen-N,S)(en)] (1) and [Pd(D-pen-N,S)(chxn)] (2), respectively. Of two diastereomers, [Pd(D-pen-N,S)(R,R-chxn)] (2(R)) and [Pd(D-pen-N,S)(S,S-chxn)] (2(S)), possible for 2, 2(S) was exclusively isolated in a high yield.
Achieving visible light-driven hydrogen evolution at positive bias with a hybrid copper–iron oxide|TiO<sub>2</sub>-cobaloxime photocathode (2020)

H<sub>2</sub>is an environmentally-friendly fuel that would allow for a circular economy but its sustainable production from solar energy and water using stable, efficient and scalable Earth-abundant materials, remains a challenge.
Effect of electrospray needle voltage on electroosmotic flow in capillary electrophoresis-mass spectrometry (1999)

The effect of the electrospray ionization (ESI) needle voltage on the electroosmotic flow (EOF) in capillary electrophoresis (CE)-mass spectrometry (MS) was investigated. The radial electric field that penetrates across the CE capillary wall imposed by the ESI needle voltage modifies the typical EOF. This effect was investigated for buffers commonly used in CE-MS. Variations as high as ±30% were observed.
Hybrid cell vaccination for cancer immune therapy: First clinical trial with metastatic melanoma (2000)

Hybrid cell vaccination is a new cancer immune therapy approach that aims at recruiting T cell help for the induction of tumour specific cytolytic immunity. The vaccines are generated by fusion of the patients' tumour cells with allogeneic MHC class II bearing cells to combine the tumour's antigenicity with the immunogenicity of allogeneic MHC molecules. Safety and anti-tumour activity of this treatment were assessed in a clinical trial that has yielded one complete and one partial remission, and 5 cases of stable disease among 16 patients with advanced stage metastatic melanoma. As evidenced by histology, the vaccination induced T cell relocation into tumour nodules. Stable disease could be maintained by repeated booster injections for more than 24 months in some patients. The side effects were minor. Occasional occurrences of vitiligo spots after vaccination were indicative of a restricted therapy induced auto-immune reactivity. The results suggest that hybrid cell vaccination is a safe cancer immune therapy potentially effective for induction of acute anti-tumour response as well as long-term maintenance. Int. J. Cancer 85:618–626, 2000. © 2000 Wiley-Liss, Inc.
High expression levels of p27 correlate with lymph node status in a subset of advanced invasive breast carcinomas (2002)

BACKGROUND The cyclin-dependent kinase inhibitor p27 plays a central role in cell cycle progression and is deregulated in breast carcinomas. Although its levels are inversely associated with tumor proliferation, overexpression of p27 has been reported in a subset of rapidly proliferating breast carcinoma cell lines. METHODS p27 levels were determined by immunohistochemistry in a series of 52 sporadic invasive breast carcinomas consisting of 47 ductal, 2 lobular, and 3 mixed; most tumors were Grade 2 or 3 (46 of 52) and Tumor Node Metastasis (TNM) Stage II–IV (46 of 52). E-cadherin expression and its gene alterations at 16q22.1 were also studied, because in vitro evidence suggests a biologic association between p27 and E-cadherin-mediated growth suppression. RESULTS The mean p27 labeling index (LI; percentage of p27 positive tumor cells) was 33.3% ± 25.3% (range, 0.1–85%). High p27 levels (p27 LI, > 50%) were observed in 14 (26.9%) of 52 carcinomas and were significantly associated with metastatic disease in axillary lymph nodes (14 of 33 vs. 0 of 19; P = 0.0007 by Fisher exact test). In addition, p27 LI was higher in the group of lymph node positive vs. lymph node negative tumors (mean p27 LI, 40.9% vs. 20.1%; P = 0.008 by Mann-Whitney test). Reduced or absent E-cadherin expression was found in 27 of 45 (60%) informative cases. Allelic imbalance of the 16q22.1 locus was found in 14 (27.5%) of 51 cases by using the microsatellite markers D16S503, D16S752, and D16S512. p27 LI and E-cadherin alterations were not statistically related. CONCLUSIONS In summary, high p27 levels detected in a subset of advanced breast carcinomas correlate with lymph node metastasis, suggesting that other mechanisms may bypass the cell cycle inhibitory role of p27 and provide growth advantage in these tumors. Cancer 2002;94:2454–65. © 2002 American Cancer Society. DOI 10.1002/cncr.10505
16x16 SLM with Silicon CMOS Drivers and III-V Modulators (1995)

Hybrid integration of III-V based optical devices, such as modulators, LEDs, and lasers, with silicon VLSI technology promises cost effective solutions to many optoelectronic challenges. It combines the low cost, high density, and high yield of silicon circuitry with the unique optical properties of III-V devices. Flip-chip bonding is a mature and commercial technology. It provides a means of reliable, rapid integration of these two types of devices. 1
ChemInform Abstract: Synthesis of Deoxyglycosyl Dithiocarbonic Acid Derivatives. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Recent Advances in Heterogeneous Catalysis for Ammonia Synthesis (2020)

Abstract Even after a century, ammonia (NH 3 ) synthesis from nitrogen and hydrogen through Haber‐Bosch process is still energy intensive. Even with recently introduced second generation Ru based catalysts with superior performance over commercial Fe based catalysts, there is still place for upgrading with new approach using advanced materials in catalyst formulation. The alkali and alkaline metal promoted Ru supported carbon and metal oxide catalyst attracted attention at initial stage and extensively studied for NH 3 synthesis in the 20 th century. Until recently, advanced materials such as electrides, hydrides, nitrides, oxides and oxy‐hydrides‐nitrides studied as support and active component of catalyst fascinated much attention, with milder reaction conditions for NH 3 synthesis. These materials with unique properties of reversible storage of electrons, hydrides, nitrides and oxygen vacancies enrich electron density on Ru catalyst and cleave N≡N bond with very low activation energy (&lt;60 kJ/mol). The mechanistic understanding of these materials leads to the fact that activation N≡N bond is no more rate‐determining step (RDS). Instead, formation of N−H bond is RDS, pushing towards an innovative research directions and scientific basis for development of new catalysts. Enormous maturation of experimental and theoretical methods with improved precession over worldwide research effort helped in gaining a fundamental understanding of these materials in NH 3 synthesis. The most of Ru supported on these advanced materials were better in performance compared to benchmark Cs−Ru/MgO and Ru/AC catalysts in NH 3 synthesis. Insights on these materials and their mechanism are covered in this review, which digs towards finding a realistic catalyst for NH 3 synthesis.
On the Amidation of 17‐Deacetyl‐Vinblastine With the Ethylesters of Some Aminoacids (1985)

Abstract We describe the synthesis of amides between 17‐deacetylvinblastine (1) and the ether esters of valine (2), leucine (3), isoleucine (4), tryptophane (5) and valine‐tryptophane (6).
Dual-Affinity Re-Targeting proteins direct T cell–mediated cytolysis of latently HIV-infected cells (2020)

Enhancement of HIV-specific immunity is likely required to eliminate latent HIV infection. Here, we have developed an immunotherapeutic modality aimed to improve T cell–mediated clearance of HIV-1–infected cells. Specifically, we employed Dual-Affinity Re-Targeting (DART) proteins, which are bispecific, antibody-based molecules that can bind 2 distinct cell-surface molecules simultaneously. We designed DARTs with a monovalent HIV-1 envelope-binding (Env-binding) arm that was derived from broadly binding, antibody-dependent cellular cytotoxicity–mediating antibodies known to bind to HIV-infected target cells coupled to a monovalent CD3 binding arm designed to engage cytolytic effector T cells (referred to as HIVxCD3 DARTs). Thus, these DARTs redirected polyclonal T cells to specifically engage with and kill Env-expressing cells, including CD4+ T cells infected with different HIV-1 subtypes, thereby obviating the requirement for HIV-specific immunity. Using lymphocytes from patients on suppressive antiretroviral therapy (ART), we demonstrated that DARTs mediate CD8+ T cell clearance of CD4+ T cells that are superinfected with the HIV-1 strain JR-CSF or infected with autologous reservoir viruses isolated from HIV-infected–patient resting CD4+ T cells. Moreover, DARTs mediated CD8+ T cell clearance of HIV from resting CD4+ T cell cultures following induction of latent virus expression. Combined with HIV latency reversing agents, HIVxCD3 DARTs have the potential to be effective immunotherapeutic agents to clear latent HIV-1 reservoirs in HIV-infected individuals.
Localization of multiple sources using time-difference of arrival measurements (2017)

This paper addresses the problem of localizing an unknown number of static sources emitting unknown signals from time-difference of arrival (TDOA) measurements. Based on the framework of random finite sets and finite set statistics, we formulate the Bayesian estimation problem and develop a particle-based localization algorithm that overcomes the challenges related to the highly non-linear TDOA measurement model, the data associations uncertainty, and the uncertainty in the number of sources to be localized. Simulation results confirm that the number of sources can be determined correctly and accurate location estimates can be obtained when the number of false alarms is low and the probability of detection is high.
Voltage-gated potassium channels (K&lt;sub&gt;v&lt;/sub&gt;) in GtoPdb v.2021.3 (2021)

The 6TM family of K channels comprises the voltage-gated KV subfamilies, the EAG subfamily (which includes hERG channels), the Ca2+-activated Slo subfamily (actually with 7TM, termed BK) and the Ca2+-activated SK subfamily. These channels possess a pore-forming α subunit that comprise tetramers of identical subunits (homomeric) or of different subunits (heteromeric). Heteromeric channels can only be formed within subfamilies (e.g. Kv1.1 with Kv1.2; Kv7.2 with Kv7.3). The pharmacology largely reflects the subunit composition of the functional channel.