gebhart/patrepeval huggingface dataset:
Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaBalpha: correlation with induction of cyclooxygenase-2 (2002)

Cigarette smoke (CS) contains several carcinogens known to initiate and promote tumorigenesis and metastasis. Because various genes that mediate carcinogenesis and tumorigenesis are regulated by nuclear factor-kappaB (NF-kappaB), we postulated that the effects of CS must be mediated through activation of this transcription factor. Therefore, in the present report we investigated whether cigarette smoke condensate (CSC) activates NF-kappaB, and whether the pathway employed for activation is similar to that of TNF, one of the potent activators of NF-kappaB. Our results show that the treatment of human histiocytic lymphoma U-937 cells with CSC activated NF-kappaB in a dose- and time-dependent manner. The kinetics of NF-kappaB activation by CSC was comparable with that of TNF. CSC-induced NF-kappaB activation was not cell type-specific, as it also activated NF-kappaB in T cells (Jurkat), lung cells (H1299), and head and neck squamous cell lines (1483 and 14B). Activation of NF-kappaB by CSC correlated with time-dependent degradation of IkappaB(alpha), an inhibitor of NF-kappaB. Further studies revealed that CSC induced phosphorylation of the serine residue at position 32 in IkappaB(alpha). In vitro immunocomplex kinase assays showed that CSC activated IkappaB(alpha) kinase (IKK). The suppression of CSC-activated NF-kappaB-dependent reporter gene expression by dominant negative form of IkappaB(alpha), TRAF2, NIK and IKK suggests a similarity to the TNF-induced pathway for NF-kappaB. CSC also induced the expression of cyclooxygenase-2, an NF-kappaB regulated gene product. Overall, our results indicate that through phosphorylation and degradation of IkappaB(alpha), CSC can activate NF-kappaB in a wide a variety of cells, and this may play a role in CS-induced carcinogenesis.
5 9Co spin echo NMR in the Co3−<i>x</i>Fe<i>x</i>B system (1987)

5 9Co nuclear magnetic resonance (NMR) was studied by a spin echo technique in a series of Co3−xFexB (0≤x≤1.5) crystalline compounds in zero magnetic field at the temperature of 4.2 K. A revised interpretation of 59Co NMR spectrum in Co3B is given, based on the theory of NMR inside the domain wall. Iron was found to cause reorientation of the easy axis in Co3B.
Metronidazole in the prophylaxis and treatment of anaerobic infection. (1978)

The influence of prophylactic metronidazole on vaginal carriage rates of anaerobes and the development of postoperative anaerobic infection was studied in 104 women who underwent abdominal hysterectomy. Metronidazole prophylaxis in 54 patients led to a decrease in the anaerobe vaginal carriage rate from 65% pre-operatively to 17% and 28% on the 3rd and 7th postoperative days respectively. In the control group (50 patients) no significant decrease in anaerobe yield was noted, corresponding percentages being 72%, 64%, and 74%. Postoperative infection occurred in 36 patients (28 controls; 8 on prophylactic metronidazole). Wound swabs from all 8 patients in the latter group yielded aerobes, and in 1 patient mixed infection (aerobes/anaerobes) occurred. In 7 of these patients (including the patient with mixed infection), the infection resolved spontaneously, while the 8th patient responded to therapy with metronidazole, kanamycin and ampicillin. In the control patients, 21 cases of postoperative wound infection and 4 of vault infection were seen; wound swabs from patients in the former group yielded aerobes in only 6 cases, and mixed growth of aerobes/anaerobes in 10 cases. Postoperative wound/vault infections in control patients cleared spontaneously in 18 cases and responded to imidazole therapy, with or without ampicillin and kanamycin, in 7 cases.
Integrating neural networks and knowledge-based systems for intelligent robotic control (1990)

A methodology is presented for integrating artificial neural networks and knowledge-based systems for the purpose of robotic control. The integration is patterned after models of human motor skill acquisition. The initial control task chosen to demonstrate the integration technique involves teaching a two-link manipulator how to make a specific type of swing. A three-level task hierarchy is defined consisting of low-level reflexes, reflex modulators, and an execution monitor. The rule-based execution monitor first determines how to make a successful swing using rules alone. It then teaches cerebellar model articulation controller (CMAC) neural networks how to accomplish the task by having them observe rule-based task execution. Following initial training, the execution monitor continuously evaluates neural network performance and re-engages swing-maneuver rules whenever changes in the manipulator or its operating environment necessitate retraining of the networks. Simulation results show the interaction between rule-based and network-based system components during various phases of training and supervision.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Computer‐Intensive Methods (2001)

Abstract With recent advances in the power of personal computers, reference distributions of statistics are now often generated using computer‐intensive methods. Several terms are erroneously used interchangeably when referring to such computer‐intensive statistical methods, including ‘resampling techniques’, ‘Monte Carlo’, ‘permutation’, ‘randomization’ and ‘bootstrap’. These techniques are not interchangeable but are fundamentally different in terms of their statistical mechanics. The generic terms ‘resampling techniques’ and ‘computer‐intensive methods’ refer to all methods in which the observed data are used to generate a reference distribution by means of randomization. This reference distribution is then used to assess the significance of a statistic calculated from the observed (not randomized) data. Significance is evaluated under the assumption that the statistic computed using the observed data is sampled from the reference distribution generated with a randomization technique.
Radiation hardness evaluation of a 130 nm SiGe BiCMOS technology for the ATLAS electronics upgrade (2010)

Final results for a comprehensive radiation hardness evaluation of a high performance, low cost, 130 nm SiGe BiCMOS technology are presented. After a survey of several available SiGe technologies, one was chosen in terms of performance, power consumption, radiation hardness, and cost and it is presented as a suitable technology for the front-end electronics of the Inner Detector and the Liquid Argon calorimeter. Gamma, neutron and proton irradiations have been performed up to target dose and fluence values, together with ELDRS assessment.
supplemental tables 1-5 and figure legends from Copy Number Changes Are Associated with Response to Treatment with Carboplatin, Paclitaxel, and Sorafenib in Melanoma (2023)

&lt;p&gt;Supplemental Table 1: Genes analyzed which are known to be involved in melanoma pathogenesis Supplemental Table 2: Patient demographics and disease characteristics Supplemental Table 3: Clinical outcomes Supplemental Table 4: BRAF gene amplification is associated with BRAF somatic mutations Supplemental Table 5: RAF1 gene amplification is associated with worse PS Supplemental Figure Legends&lt;/p&gt;
Electron affinities of the alkali halides and the structure of their negative ions (1986)

Photoelectron spectra are reported for the MX (X̃ 1Σ+)+e−←MX−(X̃ 2Σ+) transitions of ten alkali halide anions at 488 nm. Adiabatic electron affinities (±0.010 eV) are determined to be 0.593 (LiCl), 0.520 (NaF), 0.727 (NaCl), 0.788 (NaBr), 0.865 (NaI), 0.582 (KCl), 0.642 (KBr), 0.728 (KI), 0.543 (RbCl), and 0.455 eV (CsCl). Fundamental vibrational frequencies, equilibrium bond lengths, and dissociation energies are also reported for the anion 2Σ+ ground states. An observed linear correlation of electron affinities with α/r2 (α=metal atom polarizability) is used to predict the electron affinities of the remaining alkali bromides and iodides, as well as related alkali salts. A simple electrostatic model for the alkali halide anions is also presented which enables the accurate (±0.1 eV) calculation of electron affinities.
Automorphism Faithfulness Metrics for Symmetric Graph Drawings (2022)

In this article, we present new quality metrics for symmetric graph drawing based on group theory. Roughly speaking, the new metrics are faithfulness metrics, i.e., they measure how faithfully a drawing of a graph displays the ground truth (i.e., geometric automorphisms) of the graph as symmetries. More specifically, we introduce two types of automorphism faithfulness metrics for displaying: (1) a single geometric automorphism as a symmetry (axial or rotational), and (2) a group of geometric automorphisms (cyclic or dihedral). We present algorithms to compute the automorphism faithfulness metrics in O(n logn) time. Moreover, we also present efficient algorithms to detect exact symmetries in a graph drawing. We then validate our automorphism faithfulness metrics using deformation experiments. Finally, we use the metrics to evaluate existing graph drawing algorithms to compare how faithfully they display geometric automorphisms of a graph as symmetries.
(Invited) Soft Materials Approaches to Carbon Nanotubes: From Gels to Composites (2013)

Abstract not Available.
Acquisition/Processing: Machine learning-based deblending: Dispersed source array data example (2021)

Abstract Machine learning (ML) has proven its value in the seismic industry with successful implementations in areas of seismic interpretation such as fault and salt dome detection and velocity picking. The field of seismic processing research also is shifting toward ML applications in areas such as tomography, demultiple, and interpolation. Here, a supervised ML deblending algorithm is illustrated on a dispersed source array (DSA) data example in which both high- and low-frequency vibrators were deployed simultaneously. Training data pairs of blended and corresponding unblended data were constructed from conventional (unblended) data from another survey. From this training data, the method can automatically learn a deblending operator that is used to deblend for both the low- and the high-frequency vibrators of the DSA data. The results obtained on the DSA data are encouraging and show that the ML deblending method can offer a good performing, less user-intensive alternative to existing deblending methods.
Élaboration de carbures cémentés à gradient de propriétés par procédé d’imbibition réactive : Application aux inserts WC-Co et aux taillants en diamant polycristallin pour le forage pétrolier en conditions sévères (2014)

In oil drilling industry, harsher working conditions require ever new and more abrasive wear and impact resistant tools. To meet this challenge, the work presented here, is to develop graded cemented carbide materials by reactive imbibition process. This method can be divided into two gradation processes, namely, reactive coating and imbibition. Imbibition gradually enriches the core of dense cemented carbide with binder phase and is based on the principle of liquid phase migration in a solid-liquid body. Reactive coating also takes place in dense cemented carbide on which a boron nitride coating is deposited. After reaction with the WC-Co liquid binder, some ternary boride precipitations take place from surface to several millimeters deep. For industrial parts (inserts for roller cone bits and PDC (Polycrystalline Diamond Compact) cutters substrates), hardness gradients obtained can reach 450 HV on 25 mm. Such gradients development is passed through a better understanding of kinetics and phenomena occurring during imbibition and reactive coating. In case of PDC cutters, influence of HPHT process parameters, allowing diamond table synthesis, on the WC-Co substrate gradient, generated by reactive imbibition, was studied. This work was also interested in gradient effect on the obtained diamond tables properties. After mechanical tests, graded WC-Co inserts and graded PDC cutters show a significant increase of both wear resistance (from 30 to 100%) and impact resistance (from 20 to 40%).
Through-Space Higher Dimensionality Conjugation to Enhance Optical Properties? An Exploratory Computational Investigation on a Model System (1998)

AMPAC (Semichem Inc.) AM1 semiempirical calculations on stacked benzene delocalized ring systems suggest that very large third-order polarizabilities (γ) can be obtained. Systems of +2 charge consisting of benzene rings separated by 3 Å display finite-field (FF) zero frequency γ(0;0,0;0)s that are many orders of magnitude larger than any thus far commonly encountered or previously predicted for organics. The ratio of the FF Re{γ} to Re{α} is an increasing function with system size for the +2 species and is a decreasing function for the neutral species. Up to 14 rings, the largest systems currently calculated, there is not yet a clear indication of leveling off or saturation of γ or γ/α. This is discussed in the context of the absence of electron correlation in these SCF-only calculations. The feasibility of such systems is discussed, as well as potentially significant limitations to the calculations that need to be further investigated before the certainty of these predictions can be certified.
The Small Guanosine Triphosphate-Binding Protein Rab4 Is Involved in Insulin-Induced GLUT4 Translocation and Actin Filament Rearrangement in 3T3-L1 Cells* (1997)

Insulin's stimulation of glucose transport involves the translocation of vesicles containing the glucose transporter GLUT4 to the plasma membrane. Small GTP-binding proteins have been implicated in the regulation of vesicular traffic. We studied the effects of microinjection of wild-type Rab4 glutathione S-transferase fusion protein (WT Rab4), a GTP-binding defective mutant (Rab4 N121I), a guanosine triphosphatase-defective mutant (Rab4 Q67L), and a Rab4 antibody on insulin-induced GLUT4 translocation in 3T3-L1 adipocytes. Microinjection of Rab4 N121I and Rab4 antibodies had no effect on basal GLUT4 staining, but inhibited insulin-induced GLUT4 translocation by 50% compared with that in control IgG-injected cells. WT Rab4 and Rab4 Q67L microinjection had no effect on either basal or insulin-induced GLUT4 translocation. Premixing and coinjection of the Rab4 antibody with WT Rab4 almost completely abolished its inhibitory effect on insulin-induced GLUT4 translocation. In contrast, microinjection of an antibody directed against the highly conserved region of Rab3 proteins had no effect on insulin-induced GLUT4. These results point to a direct role of Rab4 in insulin-induced GLUT4 translocation, and that this effect is dependent on nucleotide binding to the protein. We also studied the effect of microinjection of the same proteins on insulin-induced actin filament rearrangement (membrane ruffling) in the same cell line. Microinjection of Rab4 N121I and Rab4 antibodies inhibited insulin-induced membrane ruffling by 40%, whereas WT Rab4 or a Rab3 antibody injection had no effect on cytoskeletal rearrangement. In summary, 1) Rab4 is a necessary component of the insulin/GLUT4 translocation signaling pathway; 2) the function of Rab4 in this pathway requires GTP binding; 3) Rab4 also participates in the process of insulin-induced membrane ruffling; and 4) Rab3 proteins do not seem to be involved in these processes.
Thermally Induced Fluid Reversed Hexagonal (H<sub>II</sub>) Mesophase (2007)

In the present study we characterized the microstructures of the Lc and HII phases in a glycerol monooleate (GMO)/tricaprylin (TAG)/water mixture as a function of temperature. We studied the factors that govern the formation of a low-viscosity HII phase at relatively elevated temperatures (>35 degrees C). This phase has very valuable physical characteristics and properties. The techniques used were differential scanning calorimetry (DSC), wide- and small-angle X-ray scattering (WAXS and SAXS, respectively), NMR (self-diffusion and (2)H NMR), and Fourier transform infrared (FTIR) spectroscopies. The reverse hexagonal phase exhibited relatively rapid flow of water in the inner channels within the densely packed cylindrical aggregates of GMO with TAG molecules located in the interstices. The existence of two water diffusion peaks reflects the existence of both mobile water and hydration water at the GMO-water interface (hydrogen exchange between the GMO hydroxyls and water molecules). Above 35 degrees C, the sample became fluid yet hexagonal symmetry was maintained. The fluidity of the HII phase is explained by a significant reduction in the domain size and also perhaps cylinder length. This phenomenon was characterized by higher mobility of the GMO, lower mobility of the water, and a significant dehydration process.
SU-E-T-515: Implementation of Gated Beam Delivery at the Heidelberg Ion-Beam Therapy Center (2011)

Purpose: Gated beam delivery was successfully implemented for research purposes at the Heidelberg Ion-Beam Therapy Center (HIT). Basic functionality of gating with scanned ion beams was tested in comparison to non-gated beam delivery. Methods: The therapy control system and the user control system were upgraded to interface with the Anzai® Respiratory Gating system. Basic features of the implementation were tested. A Bragg- Peak chamber served as a detector for measuring the dosimetric precision of single beam spots. Delay times for pausing and resuming the beam delivery were measured using a pulse detector. Results: No relevant differences were obtained for the particle numbers of beam spots delivered with or without interruptions due to gating. Measured delay times for pausing and resuming beam delivery were about 250μs and 25ms, respectively Conclusions: Gating is available for research purposes at HIT by use of the Anzai System. Gated beam delivery with scanned ion beams shows very good performance in dosimetric and delay time measurements. This work is supported by Siemens Healthcare Sector, Particle Therapy.
On the Memory of Chirality in Gold(I)-Catalyzed Intramolecular Carboalkoxylation of Alkynes (2011)

A computational study of the mechanism of the intramolecular carboalkoxylation of alkynes reported by Toste et al. allows the characterization of the chirality transfer process that makes this reaction enantioselective. Memory of chirality is preserved up until the stereocenter-generating iso-Nazarov cyclization through the synergy between the helicity of a pentadienyl cation intermediate and the control in the conformation of the allyl group, both elements defined upon alkoxy migration. The high barriers to conformational scrambling relative to those corresponding to chemical steps ensure the robustness of the chirality transfer mechanism and result in an unusual importance of conformational changes in reactivity that seems to be common in gold-catalyzed transformations.
Functional and Phenotypic Characterization Of Acute Myeloid Leukemia By Analysis Of Diagnostic/Relapse Paired Samples (2013)

Abstract Treatment of relapsed acute myeloid leukemia (AML) results in lower complete remission rates compared to treatment of AML at diagnosis. Immunophenotypic changes in leukemic blasts are common from diagnosis to relapse (Baer et al. Blood. 2001), suggesting that the underlying biology of AML changes with disease progression. A better understanding of the biologic properties of AML cells at different stages of disease will facilitate the development of biomarker tools and more effective therapies. We therefore studied paired diagnostic/relapse samples obtained from AML patients. Cells from 11 paired samples were transplanted into immune deficient mice (NOD.SCID IL2Rg null) over a range of cell doses. In 10 of 11 patients, a leukemic graft could be generated after transplantation of lower cell doses from the relapse sample compared to the paired diagnostic sample. By limiting dilution analysis, leukemia stem cell (LSC) frequency was higher in relapse samples (1 in 5.8×102 to 1 in 2.4×106, median 1 in 2.0×103) compared to diagnostic samples (1 in 5.0×103 to 1 in 6.1×106, median 1 in 5.5×104); the fold increase in LSC frequency ranged from 2.2 to 745 (median 8.6). Multiparameter flow cytometric analysis carried out on 13 paired diagnostic/relapse samples demonstrated an increase in 2 known stem cell markers, CD34 and CD117, from diagnosis to relapse: CD34 was gained or increased at relapse in 7/13 (54%) of paired samples, while CD117 was gained or increased at relapse in 9/13 (69%) of paired samples. We plan to take a comprehensive approach to examine the surface marker expression of paired diagnostic/relapse samples by a high throughput flow cytometric screen (HTS) of both bulk and LSC-containing AML populations to identify markers that are altered at relapse. As a first step, we have performed HTS of 373 surface markers on 10 AML patient samples, including a relapse sample from a diagnostic/relapse pair. A significant proportion of markers (155/373, 42%) were expressed on less that 5% of cells in all 10 AML samples analyzed. We will therefore focus on the remaining markers in our HTS analysis of paired samples. Surface markers that are differentially expressed from diagnosis to relapse will be further characterized in order to gain insight into disease progression and identify potential therapeutic targets. Disclosures: No relevant conflicts of interest to declare.
TNFAIP3 (tumor necrosis factor, alpha-induced protein 3) (2011)

Review on TNFAIP3 (tumor necrosis factor, alpha-induced protein 3), with data on DNA, on the protein encoded, and where the gene is implicated.
Aminations of Aryl Bromides in Water at Room Temperature (2009)

Unsymmetrical di- and triarylamines can be formed under green chemistry conditions, taking advantage of micellar catalysis leading to palladium-catalyzed aminations at ambient temperatures in water as the only medium.
Restoration of protein synthesis in lysed rabbit reticulocytes by the enzymatic removal of AMP with either AMP deaminase or AMP nucleosidase (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRestoration of protein synthesis in lysed rabbit reticulocytes by the enzymatic removal of AMP with either AMP deaminase or AMP nucleosidaseJoseph D. Mosca, Joseph M. Wu, and Robert J. SuhadolnikCite this: Biochemistry 1983, 22, 2, 346–354Publication Date (Print):January 18, 1983Publication History Published online1 May 2002Published inissue 18 January 1983https://pubs.acs.org/doi/10.1021/bi00271a018https://doi.org/10.1021/bi00271a018research-articleACS PublicationsRequest reuse permissionsArticle Views36Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Surface-acoustic-wave-driven acoustooptic modulator with wide wavelength range for visible laser light (2008)

A surface-acoustic-wave-driven acoustooptic modulator was fabricated on 128° Y-cut LiNbO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> for visible laser light. Peak diffraction efficiencies of 85, 82, and 47% were obtained for optical wavelengths of 633, 532, and 473 nm, respectively.