gebhart/patrepeval huggingface dataset:
The SH3 Domain of Crk Binds Specifically to a Conserved Proline-rich Motif in Eps15 and Eps15R (1995)

The Crk protein belongs to the family of proteins consisting of mainly Src homology 2 and 3 (SH2 and SH3) domains. These proteins are thought to transduce signals from tyrosine kinases to downstream effectors. In order to understand the specificity and effector function of the SH3 domain of Crk, we screened an expression library for binding proteins. We isolated Eps15, a substrate of the epidermal growth factor receptor (EGFR) tyrosine kinase, and Eps15R, a novel protein with high sequence homology to the carboxyl-terminal domain of Eps15. Antibodies raised against a fragment of the Eps15R gene product immunoprecipitated a protein of 145 kDa. Eps15 and Eps15R bound specifically to the amino-terminal SH3 domain of Crk and coprecipitated equivalently with both c-Crk and v-Crk from cell lysates. The amino acid sequences of Eps15 and Eps15R featured several proline-rich regions as putative binding motifs for SH3 domains. In both Eps15 and Eps15R, we identified one proline-rich motif which accounts for their interaction with the Crk SH3 domain. Each binding motif contains the sequence P-X-L-P-X-K, an amino acid stretch that is highly conserved in all proteins known to interact specifically with the first SH3 domain of Crk. Furthermore, we found that immunoprecipitates of activated EGFR-kinase stably bound in vitro-translated Eps15 only in the presence of in vitro-translated v-Crk. Crk might therefore be involved in Eps15-mediated signal transduction through the EGFR.
CCDC 813379: Experimental Crystal Structure Determination (2011)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
&lt;title&gt;Cross-correlation of ultrasound A-lines to obtain dynamic displacement profiles within poroelastic materials undergoing stress relaxation&lt;/title&gt; (2000)

One technique of elasticity imaging, elastography, uses cross- correlation between two ultrasound A-lines to obtain an axial strain image of a sample. Usually, great care is taken with respect to the assumption that the response of the sample is elastic (lossless). In this paper, we relax this assumption and extend elastography to estimate the time-varying displacement and strain status of small samples (of the order of 1 mm). Results are presented for gel phantoms and articular cartilage samples, and they are consistent with the current theories of poroelastic materials. For example, an effective Poisson's ratio of approximately 0.5 obtained at ramp completion indicates volume conservation since the ramp time was much shorter than the characteristic relaxation time of the material. Subsequent reduction in effective Poisson's ratio coincident with stress-relaxation confirms poroelastic mechanisms whereby fluid exudation dissipates internal fluid pressurization. Observed slower relaxation of strain at the center of the sample is also compatible with these types of models. Preliminary data obtained with articular cartilage also shows valuable potential of this technique to investigate tissue biomechanics.
Calcium polyphosphate as an additive to zinc-silicate glass ionomer cements (2015)

Aluminum-free glass ionomer cements (GICs) are under development for orthopedic applications, but are limited by their insufficient handling properties. Here, the addition of calcium polyphosphate (CPP) was investigated as an additive to an experimental zinc-silicate glass ionomer cement. A 50% maximum increase in working time was observed with CPP addition, though this was not clinically significant due to the short working times of the starting zinc-silicate GIC. Surprisingly, CPP also improved the mechanical properties, especially the tensile strength which increased by ∼33% after 30 days in TRIS buffer solution upon CPP addition up to 37.5 wt%. This strengthening may have been due to the formation of ionic crosslinks between the polyphosphate chains and polyacrylic acid. Thus, CPP is a potential additive to future GIC compositions as it has been shown to improve handling and mechanical properties. In addition, CPP may stimulate new bone growth and provide the ability for drug delivery, which are desirable modifications for an orthopedic cement.
Relapse of Pneumocystis carinii pneumonia in the upper lobes during aerosol pentamidine prophylaxis. (1989)

Pneumocystis carinii pneumonia was diagnosed by bronchoalveolar lavage of the upper lobes in a patient with the acquired immunodeficiency syndrome (AIDS) receiving aerosol pentamidine prophylaxis. Serendipitous availability of a normal premorbid lung gallium scan indicated that pneumocystosis had developed during aerosol pentamidine prophylaxis; at the time of presentation a repeat gallium scan indicated disease limited to the upper lobes. The relation of this unusual form of isolated upper lobe Pneumocystis carinii pneumonia to aerosol pentamidine prophylaxis warrants further investigation.
What it means for a concurrent program to satisfy a specification (1985)

The formal correspondence between an implementation and its specification is examined. It is shown that existing specifications that claim to describe priority are either vacuous or else too restrictive to be implemented in some reasonable situations. This is illustrated with a precisely formulated problem of specifying a first-come-first-served mutual exclusion algorithm, which it is claimed cannot be solved by existing methods.
Seed Priming With Protein Hydrolysates Improves Arabidopsis Growth and Stress Tolerance to Abiotic Stresses (2021)

The use of plant biostimulants contributes to more sustainable and environmentally friendly farming techniques and offers a sustainable alternative to mitigate the adverse effects of stress. Protein hydrolysate-based biostimulants have been described to promote plant growth and reduce the negative effect of abiotic stresses in different crops. However, limited information is available about their mechanism of action, how plants perceive their application, and which metabolic pathways are activating. Here we used a multi-trait high-throughput screening approach based on simple RGB imaging and combined with untargeted metabolomics to screen and unravel the mode of action/mechanism of protein hydrolysates in Arabidopsis plants grown in optimal and in salt-stress conditions (0, 75, or 150 mM NaCl). Eleven protein hydrolysates from different protein sources were used as priming agents in Arabidopsis seeds in three different concentrations (0.001, 0.01, or 0.1 μl ml<sup>-1</sup>). Growth and development-related traits as early seedling establishment, growth response under stress and photosynthetic performance of the plants were dynamically scored throughout and at the end of the growth period. To effectively classify the functional properties of the 11 products a Plant Biostimulant Characterization (PBC) index was used, which helped to characterize the activity of a protein hydrolysate based on its ability to promote plant growth and mitigate stress, and to categorize the products as plant growth promoters, growth inhibitors and/or stress alleviator. Out of 11 products, two were identified as highly effective growth regulators and stress alleviators because they showed a PBC index always above 0.51. Using the untargeted metabolomics approach, we showed that plants primed with these best performing biostimulants had reduced contents of stress-related molecules (such as flavonoids and terpenoids, and some degradation/conjugation compounds of phytohormones such as cytokinins, auxins, gibberellins, etc.), which alleviated the salt stress response-related growth inhibition.
Statins as potential therapeutic agents in neuroinflammatory disorders (2003)

Purpose of review Multiple sclerosis is a central nervous system inflammatory demyelinating disease that is thought to have an autoimmune pathogenesis. Recent results indicate that ‘statins’, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, which are the most commonly used oral cholesterol-lowering drugs, have immunomodulatory properties. In this article we will review those findings that indicate that statins may be beneficial in the treatment of multiple sclerosis, neurodegenerative disease, and ischemic stroke. Recent findings It was reported that statin treatment could either inhibit or reverse chronic and relapsing experimental autoimmune encephalomyelitis, a model of multiple sclerosis. Several immunomodulatory properties of statins may account for their beneficial clinical effect: Statins decreased the migration of leukocytes into the central nervous system, inhibited MHC class II and costimulatory signals required for activation of proinflammatory T cells, induced a TH2 phenotype in T cells, and decreased the expression of inflammatory mediators in the central nervous system, including nitric oxide and tumor necrosis factor alpha. It was also demonstrated that statin use significantly reduced beta-amyloid secretion in the cerebrospinal fluid of experimental animals. Clinically, there is emerging evidence that statins have beneficial effects in patients with multiple sclerosis, Alzheimer's disease, and ischemic stroke. Summary In-vitro studies have indicated that statins may have anti-inflammatory properties. Results from in-vivo animal models suggest that statins may be beneficial in treatment of different central nervous system conditions. Larger scale, randomized, double-blind trials are needed to validate the role of statins as a treatment of inflammatory central nervous system diseases.
Effect of Loading Level and Rate in the Indirect Tensile Test (2007)

University. The contents of this paper reflect the views of the author(s), who are responsible for the facts and accuracy of the information presented herein.
Leishmania vaccine development: exploiting the host–vector–parasite interface (2015)

Visceral leishmaniasis (VL) is a disease transmitted by phlebotomine sand flies, fatal if untreated, and with no available human vaccine. In rodents, cellular immunity to Leishmania parasite proteins as well as salivary proteins of the sand fly is associated with protection, making them worthy targets for further exploration as vaccines. This review discusses the notion that a combination vaccine including Leishmania and vector salivary antigens may improve vaccine efficacy by targeting the parasite at its most vulnerable stage just after transmission. Furthermore, we put forward the notion that better modeling of natural transmission is needed to test efficacy of vaccines. For example, the fact that individuals living in endemic areas are exposed to sand fly bites and will mount an immune response to salivary proteins should be considered in pre-clinical and clinical evaluation of leishmaniasis vaccines. Nevertheless, despite remaining obstacles there is good reason to be optimistic that safe and effective vaccines against leishmaniasis can be developed.
Integrity of Visual Navigation—Developments, Challenges, and Prospects (2022)

<h3>Summary</h3> Camera-based visual navigation has great potential for various applications, especially in satellite-signal-degenerated environments. However, the lack of integrity protection has constrained its utilization in safety-critical applications. Integrity characterizes the quality of the information that a navigation system delivers. Integrity frameworks have been developed over decades for satellite navigation, and continue to play an essential role in safety-critical applications like civil aviation. Nevertheless, there are several challenges to quantify the risks associated with visual navigation. Over the last few years, several approaches to tackle these challenges have been investigated. These developments are the first steps toward a reliable visual positioning framework with integrity monitoring capabilities. In this paper, we review the current status, particular challenges, and development trends in visual positioning integrity monitoring. In addition, we propose a preliminary framework so that the future developments on visual navigation integrity can benefit from a systematic approach.
Network Stiffening and Chemical Ordering in Chalcogenide Glasses: Compositional Trends of Tg in Relation to Structural Information From Solid and Liquid State NMR (2005)

In summary the results of the present study illustrate the utility of solid- and molten-state NMR spectroscopy to provide valuable information on short- and medium-range ordering effects in non-oxide chalcogenide glasses. P-Se glasses with their efficient competition between homo- and heteropolar bond formation are the most ideal model systems for mean-field theory. Accordingly a dramatic change in dTg/d<r> is observable at the percolation threshold <r>=2.40. In contrast, As-Se and Ge-Se systems display a pronounced preference for heteropolar bond formation, resulting in chemical threshold effects that are superimposed upon the effects of physical percolation. These chemical threshold effects produce Tg maxima at compositions corresponding to R=1, where heteropolar bond formation is maximized. In ternary Ge-Se-X systems (X=P,As,Sb) these chemical threshold effects disappear because the formation of homopolar bonds is controlled by a strong secondary hierarchy. Over wide compositional regions of Se-deficient glasses this hierarchy serves to minimize the formation of Ge-Ge bonds and can be held responsible for the observation of universal Tg vs. <r> dependences. Based on these results we predict that physical threshold behavior will in general be observable not only in those glass systems having no bonding preferences, but also in those ternary glass systems in which chemical ordering is observed, but where there is a clear secondary hierarchy of heteropolar bond formation. The most striking example is the Ge-P-Se glass system; other examples can be envisioned for tellurium-based chalcogenide glass systems Ge-X-Te. In contrast, no such secondary hierarchy is expected for sulfide-based glasses (such as Ge-X-S), where we envision heteropolar Ge-S and X-S bonding to dominate the structure to such an extent that no secondary hierarchy effects are expected. The experimental varification of these ideas is currently under investigation in our laboratories.
Super-Resolution Electrochemical Impedance Imaging with a 100 × 100 CMOS Sensor Array (2021)

Abstract This paper presents a 100 × 100 super-resolution integrated sensor array for microscale electrochemical impedance spectroscopy (EIS) imaging. The system is implemented in 180 nm CMOS with 10 μ m × 10 μ m pixels. Rather than treating each electrode independently, the sensor is designed to measure the mutual capacitance between programmable sets of pixels. Multiple spatially-resolved measurements can then be computationally combined to produce super-resolution impedance images. Experimental measurements of sub-cellular permittivity distributions within single algae cells demonstrate the potential of this new approach.
The impact of strict public health measures on COVID-19 transmission in developing countries: The case of Kuwait (2020)

Abstract Background Many countries have succeeded in curbing the outbreak of COVID-19 by employing strict public health control measures. However, little is known about the effectiveness of such control measures in curbing the outbreak in developing countries. In this study, we seek to assess the impact of various outbreak control measures in Kuwait to gain more insight into the outbreak progression and the associated healthcare burden. Methods We use a SEIR mathematical model to simulate the epidemic outbreak of COVID-19 in Kuwait with additional testing and hospitalization compartments. We use a NBD observational framework for confirmed case and death counts. We forecast model trajectories and assess the effectiveness of public health interventions by using maximum likelihood to estimate both the basic and effective reproduction numbers. Results Our results indicate that the early strict control measures had the effect of delaying the intensity of the outbreak but were unsuccessful in reducing the effective reproduction number below 1. Forecasted model trajectories suggest a need to expand the healthcare system capacity to cope with the associated epidemic burden of such ineffectiveness. Conclusion Strict public health interventions may not always lead to the same desired outcomes, particularly when population and demographic factors are not accounted for as in the case in some developing countries. Real-time dynamic modeling can provide an early assessment of the impact of such control measures as well as a forecasting tool to support outbreak surveillance and the associated healthcare expansion planning. SUMMARY BOX What is already known on the subject? Evidence is accumulating about the positive impact of various strict public health interventions on the transmission of COVID-19 in the developed world. Currently, however, many developing countries are still struggling to control and suppress the initial wave of the outbreak. In particular, less attention is given to assessing the impact of taking similar strict control measures. What does this study add? Our modeling study provides the first evidence showing how the imposition of strict public health measures has not led to a reduction in COVID-19 transmission in Kuwait. It highlights the importance of performing systematic epidemiological and public health investigations of the population factors which may limit the effectiveness of standard public health interventions in developing countries. It also emphasizes the utility of adopting dynamic modeling approaches for intervention assessment and healthcare capacity re-adjustment at the earliest stages of the outbreak.
Structures and Excited States of Extended and Folded Mono-, Di-, and Tri-<i>N-</i>Arylbenzamides (2002)

The relationship between molecular structure and electronic properties of 18 N-arylbenzamides has been investigated. The secondary amides adopt extended trans-amide conformations, whereas the tertiary amides adopt folded cis-amide conformations in which the N-aryl group is approximately perpendicular to the benzoyl group. The N-aryl groups of the tertiary di- and triamides occupy the same face of the benzoyl group and display edge-to-face aryl−aryl interactions. The long-wavelength absorption maxima of the secondary amides are red-shifted as the number of N-aryl groups increases, whereas the tertiary amides display are blue-shifted. ZINDO calculations aid in the assignment of the absorption and luminescence spectra. In all cases the lowest energy singlet state is assigned to a forbidden n,B* (carbonyl lone-pair to benzoyl) transition. The structureless fluorescence of the secondary and tertiary amides is assigned to planar and twisted n,B* singlets, respectively. The allowed absorption bands are assigned to A,B* (arene-to-benzoyl) or A,A* (arene-to-arene) transitions which are localized on a single arene, and the structured phosphorescence is assigned to A,A* triplet states.
La escultura fenicia en Hispania (2010)

Esta obra es el resultado de un intenso esfuerzo, de varios anos, dirigido a dar a conocer, reunidos y bien analizados en este Corpus de la Escultura Fenicia en Hispania, uno de los testimonios materiales mas interesantes de la arqueologia fenicia y punica en la Peninsula Iberica, la antigua Hispania, que, no obstante, ha sido escasamente valorado a pesar de su gran importancia.
Chip-package interaction: Challenges and solutions to mechanical stability of Back end of Line at 28nm node and beyond for advanced flip chip application (2012)

Fhis paper discusses the extensive development work carried out by GLOBALFOUNDRIES to mitigate chip-package interaction (CPI) risks for the silicon Backend of Line (BEOL) during IC package assembly. Particularly, material property data for different ultra low k (ULK) materials, CPI qualification results and key findings made during the technology development are discussed. Newly developed test and modeling methods to expedite technology learning are also described in detail.
Signal transduction correlates of mu opioid agonist intrinsic efficacy: receptor-stimulated [35S]GTP gamma S binding in mMOR-CHO cells and rat thalamus. (1998)

This study examined the signal transduction correlates of mu opioid agonist efficacy in two systems: mu receptor-transfected mMOR-CHO cell and rat thalamic membranes. The potency and maximal stimulation of [35S]GTP gamma S binding by various agonists was measured in the presence of excess GDP and compared with receptor binding affinity under identical assay conditions. Results showed that the relative maximal stimulation produced by these agonists was greater in mMOR-CHO cell than in rat thalamic membranes; some drugs that were full agonists in mMOR-CHO cells were partial agonists in the thalamus, and some partial agonists in the transfected cells were full antagonists in the thalamus. Furthermore, there was receptor reserve for G-protein activation by some agonists in mMOR-CHO cell membranes, but no receptor reserve was detected in rat thalamic membranes. Saturation analysis of agonist-stimulated [35S]GTP gamma S binding revealed that full agonists produced both a higher Bmax and apparent affinity of [35S]GTP gamma S binding than partial agonists. Correlation of the Bmax and KD of agonist-stimulated [35S]GTP gamma S binding with agonist intrinsic efficacy revealed only a moderate correlation with either parameter alone, but a highly significant correlation (r > 0.9) with a combination of the two parameters (Bmax/KD). These results suggest that the intrinsic efficacy of agonists at G-protein-coupled receptors is determined primarily by the ability of the agonist-occupied receptor to promote high-affinity GTP binding to the G-protein and to catalytically activate a maximal number G-proteins.
ChemInform Abstract: Selective Oxidation at Carbon Adjacent to Aromatic Systems with IBX. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Experimental validation of OSNR enhancement utilizing hybrid Raman/Erbium fiber amplifiers (2005)

Abstract The impact of employing a hybrid Raman/Erbium‐doped fiber amplifier (EDFA) in a transmission system is demonstrated by considering the optical signal‐to‐noise ratio (OSNR) performance. The gain flatness of hybrid Raman/EDFA is maintained below 1.2 dB from 1530 to 1565 nm through careful design of both amplifiers. The enhancement of OSNR is measured at around 5 dB, compared to the conventional EDFA approach with a 28‐dB span loss. © 2005 Wiley Periodicals, Inc. Microwave Opt Technol Lett 45: 333–335, 2005; Published online in Wiley InterScience (www.interscience.wiley.com). DOI 10.1002/mop.20815