gebhart/patrepeval huggingface dataset:
Analysis and implications of ic cooling for deep nanometer scale cmos technologies (2006)

Cooled chip operation is being seriously evaluated as a practical technique for boosting the performance of high-end microprocessors. This paper presents, for the first time, a comprehensive analysis of chip cooling for various nanometer scale bulk-CMOS and silicon-on-insulator (SOI) technologies. Unlike all previous work, our analysis employs a holistic approach (combines device, circuit and system level considerations) and also takes various electrothermal couplings between power dissipation, operating frequency and die temperature into account. While cooling always gives performance gain at the device or circuit level, it is shown that system level power defines a temperature limit beyond which cooling gives diminishing returns and the associated cost may be prohibitive. A scaling analysis of this temperature limit is also presented. Furthermore, it is shown that on-chip thermal gradients cannot be mitigated by global chip cooling and that localized cooling can be more effective in removing hot-spots
Tolvaptan for the Treatment of Hyponatremia and Hypervolemia in Patients With Congestive Heart Failure (2013)

Patients with heart failure often show increased arginine vasopressin secretion and enhanced sympathetic and renin-angiotensin-aldosterone activation, which accelerate renal water reabsorption, causing water retention and volume overload. Tolvaptan is an orally active antagonist of arginine vasopressin type 2 receptors in the collecting duct of the kidney that inhibits water reabsorption without substantially affecting the electrolyte balance. Tolvaptan in combination with conventional diuretics improves fluid retention and congestive symptoms in patients with heart failure and volume overload, with minimal effects on hemodynamics and serum potassium. Tolvaptan slightly increases serum sodium concentrations, generally within the normal range. Although it does not seem to affect long-term mortality, tolvaptan does improve short-term water retention and congestive symptoms in heart failure patients with volume overload despite the use of conventional diuretics, and is approved for this indication in Japan.
Subcellular and regional localization of mRNA translation in midbrain dopamine neurons (2022)

Midbrain dopaminergic (mDA) neurons exhibit extensive dendritic and axonal arborizations, but local protein synthesis is not characterized in these neurons. Here, we investigate messenger RNA (mRNA) localization and translation in mDA neuronal axons and dendrites, both of which release dopamine (DA). Using highly sensitive ribosome-bound RNA sequencing and imaging approaches, we find no evidence for mRNA translation in mDA axons. In contrast, mDA neuronal dendrites in the substantia nigra pars reticulata (SNr) contain ribosomes and mRNAs encoding the major components of DA synthesis, release, and reuptake machinery. Surprisingly, we also observe dendritic localization of mRNAs encoding synaptic vesicle-related proteins, including those involved in exocytic fusion. Our results are consistent with a role for local translation in the regulation of DA release from dendrites, but not from axons. Our translatome data define a molecular signature of sparse mDA neurons in the SNr, including the enrichment of Atp2a3/SERCA3, an atypical ER calcium pump.
Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells (2006)

One of the pathways involved in SC-236-induced apoptosis in gastric cancer cells is through downregulation of Akt and then release of cytochrome c.
Platform of chiral Majorana edge modes and its quantum transport phenomena (2019)

We propose a method to create two-dimensional topological superconductors with a heterostructure of ferromagnet (FM), topological insulator (TI) thin film and superconductor, in which the two surfaces of the TI thin film are treated as a two-dimensional system. One of surfaces is superconducting due to proximity effect and the other feels an exchange field from the FM. We show that there is a topological phase with single chiral Majorana edge mode that exists in readily achievable parameter regions and does not require magnetization to be small. An experimental setup is proposed based on our model to uniquely determine the existence of Majorana chiral modes using a Josephson junction. Also, we show that multiple chiral Majorana edge modes may appear when unconventional superconductors are used.
Effects of microstructure of low temperature grown GaAs films on the properties of terahertz wave detection (2009)

Effects of microstructure of molecular beam epitaxially grown GaAs films at low temperature on the properties of terahertz detection have been investigated. Microstructural changes of the films before and after in-situ annealing strongly influence the terahertz wave SNRs in the receiver. The films grown at 150°C and in-situ annealed at 600°C showed a poly- crystalline state, and those grown at 250°C or higher temperature and in-situ annealed at 600°C revealed epitaxial GaAs layers including As-rich precipitates. The SNRs of the terahertz wave were measured to be 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> to 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> . The best value of the SNR 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sup> was obtained with the polycrystalline GaAs layer.
Studies on Steering Feeling Feedback System Based on Nonlinear Vehicle Model (2017)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The steer-by-wire system has been widely studied due to many advantages such as good controllability. In the system, the steering column is cancelled and the driver can't feel the feedback torque (also called steering feeling) coming from the ground. Therefore a steering feeling feedback system is needed. In this paper, we propose a simple method to calculate desired feedback torque based on a nonlinear 2DOF vehicle model. The vehicle model contains the nonlinearity of tire. So that the proposed method is also appropriate for big acceleration conditions. Besides that, the properties of steering system such as friction and stiffness are also taken into consideration. As for conventional steering system, driver can only feel part of the feedback torque due to the power assist system. In order to provide steering feeling similar to conventional steering system, a weighting function is proposed to compensate the influence of power assist system. At the last part of this paper, real vehicle experiments are conducted to validate the proposed method. In comparison with the test data, the steering feeling feedback algorithm can calculate desired feedback torque precisely.&lt;/div&gt;&lt;/div&gt;
Measuring service in multi-class networks (2002)

Quality of service mechanisms and differentiated service classes are increasingly available in networks and servers. While network clients can assess their service by measuring basic performance parameters such as packet loss and delay, such measurements do not expose the network's core QoS functionality. We develop a framework and methodology for enabling network clients to assess a system's multi-class mechanisms and parameters. Using hypothesis testing, maximum likelihood estimation, and empirical arrival and service rates measured across multiple time scales, we devise techniques for clients to (1) determine the most likely service discipline among EDF, WFQ, and SP, (2) estimate the server's parameters with high confidence, and (3) detect and parameterize non-work-conserving elements such as rate limiters. We describe the important role of time scales in such a framework and identify the conditions necessary for obtaining accurate and high confidence inferences.
Supplementary Table 1 from The Outcome of &lt;i&gt;Ex Vivo&lt;/i&gt; TIL Expansion Is Highly Influenced by Spatial Heterogeneity of the Tumor T-Cell Repertoire and Differences in Intrinsic &lt;i&gt;In Vitro&lt;/i&gt; Growth Capacity between T-Cell Clones (2023)

&lt;p&gt;Supplementary Table 1&lt;/p&gt;
Surface Imaging by ABF-STEM: Lithium Ions in Diffusion Channel of LIB Electrode Materials (2012)

Lithium ions in LiMn2O4 crystals have been shown observable by using an aberration corrected electron microscope (R005) which has achieved a sub-50 pm resolution. Based on the annular bright-field image of the observed image, surface imaging of a LiMn2O4 crystal is discussed through simulation. The present simulation showed that ABF images with large convergence angles are sensitive to the top surface profile. A vacancy locating at the top surface of the lithium or manganese atomic columns can be observable with contrast reduced by 10-25% from the columns without vacancy. [DOI: 10.1380/ejssnt.2012.454]
Two New Scalarane Sesterterpenes: Isoscalarafuran-A and -B, Epimeric Alcohols From a Southern Australian Marine Sponge, <i>Spongia hispida</i> (1993)

A specimen of the marine sponge Spongia hispida ( Lamarck , 1814), collected in the Great Australian Bight, has yielded the known marine sesterterpene hyrtiosal (1), together with two new scalarane sesterterpenes, isoscalarafuran-A (2) and isoscalarafuran -B (3). The structures for these two new metabolites were secured by detailed spectroscopic analysis, comparison with model compounds, and molecular modelling.
Study of a Self-Powered UWB Sensor Network for Industrial Applications (2019)

This paper presents initial results regarding the potential of ultra-wideband (UWB) technology to become an enabler of self-powered industrial sensor networks. Our study uses requirements from vibration monitoring typically implemented today with wired installations. A wireless solution can significantly reduce cost if batteries do not need to be replaced often. We discuss the key factors extending network lifetime. A charge balance analysis shows that UWB is a well-suited technology for this application. Evaluations of the network lifetime at different network operating points and against alternative wireless technologies support our statement.
4D-5 BAW Technologies: Development and Applications within MARTINA, MIMOSA and MOBILIS IST European Projects (Invited) (2006)

The paper presents recent results obtained with FBAR and SMR BAW resonators for radiofrequency microelectronics applications within three European projects. The design and implementation of an RF front-end for WCDMA applications using an above-IC BAW band-pass filter is reported (SoC integration) from MARTINA European project. The second European project (MIMOSA) proposes a SiP integration to make an ISM-band wake-up radio receiver using a selective low-noise amplifier (LNA). The selectivity is assured by a SMR-type BAW bandpass filter. The CMOS IC chip and the BAW filter are connected together by wire-bonding or by flip-chipping. The objective of the third European project (MOBILIS) is to develop a robust and cost-effective integrated high-power RF filtering technology and demonstrate the feasibility of a mixed SoC (nanometric CMOS/system integration) and SiP (BiCMOS/power-BAW) RF power transmitter. The targeted transmitter is based on a digital radio transmitter architecture and addresses both the WCDMA and DCS standards. Finally, some solutions are proposed to address the BAW technology future challenges in terms of high frequency applications (> 10 GHz), multi-standard reconfigurability, one-chip radio and combined ladder-stage with lattice stage
Phase‐1 study of abiraterone acetate in chemotherapy‐naïve Japanese patients with castration‐resistant prostate cancer (2014)

Persistent androgen synthesis under castration status in adrenal gland, testes and tumor cells is thought to be one of the major causes of development and progression of castration-resistant prostate cancer (CRPC). Abiraterone acetate (AA), the prodrug of abiraterone, which is an inhibitor of androgen synthesis enzymes, was evaluated for pharmacokinetics, pharmacodynamics, preliminary efficacy and safety in Japanese patients with CRPC in a phase-1, open-label and dose-escalation study. Chemotherapy-naïve Japanese CRPC patients (N = 27) received one of four AA daily doses (250 mg [n = 9], 500 mg [n = 6], 1000 [1 h premeal] mg [n = 6] and 1000 [2 h postmeal] mg [n = 6]) continuously through 28-day treatment cycles. In the first cycle, AA monotherapy was given on days 1-7 for pharmacokinetics, and AA plus prednisone (5 mg twice daily) from days 8 to 28. Of 27 patients, 9 continued treatment with AA until the data cut-off date (18 July 2013). Over the evaluated dose range, plasma abiraterone concentrations increased with dose, with median tmax 2-3 h. At each dose level, mean serum corticosterone concentrations increased, while testosterone and dehydroepiandrosterone sulfate concentrations rapidly decreased following a single AA dose and were further reduced to near the quantification limit on day 8 regardless of the dose. At least 3 patients from each dose-group experienced ≥50% prostate-specific antigen reduction, suggesting clinical benefit from AA in Japanese CRPC patients. AA was generally well-tolerated, and, therefore, the recommended AA dosage regimen in Japanese CRPC patients is 1000 mg oral dose under modified fasting conditions (at least 1 h premeal or 2 h postmeal). This study is registered at ClinicalTrials.gov: NCT01186484.
Simplified calibration procedure for Mueller polarimeter in transmission configuration (2014)

We address calibration of Mueller polarimeters in transmission configuration and in the presence of noise. By comparing the maximum likelihood (ML) method and the extended eigenvalue calibration method, it is found that the ML method yields higher precision in the presence of noise. Moreover, we show that by employing the ML method together with simple constraints on the calibration matrices, it is possible to perform the calibration without using a retarder, and with only polarizers. This result is of great interest for the calibration of multispectral polarimeters.
A Brain-Machine Interface with an Innovative Spiking Neural Network Decoder (2011)

Motor prostheses aim to restore functions lost to neurological disease and injury by translating neural signals into control signals for prosthetic limbs. Despite compelling proof of concept systems, barriers to clinical translation—mainly strict power dissipation constraints—still remain. The proposed solution is to use the ultra-low-power neuromorphic approach to potentially meet these constraints.
Optoelectronic devices for optical chaos communications (2003)

We present results on the state of the art in optoelectronic devices for chaos generation and message encryption/extraction. We concentrate on two kind of chaos based emitters and receivers: a semiconductor laser subject to all optical feedback and operating in a non linear regime and a semiconductor laser subject to nonlinear electro optical feedback and operating in a linear regime. We show that both configuration give very good synchronization properties and are suitable for message enconding/decoding at bit rates as high as Gbit/s.
Additional AC losses due to alternating magnetic field component longitudinal to strand axis in the armature winding of fully superconducting generators (1993)

The armature winding of fully superconducting generators will be constructed by multiply stacked cables of multifilamentary superconducting strands. In the superconducting cable exposed to an alternating transverse magnetic field, additional AC losses called longitudinal losses are generated by a field component longitudinal to the strand, because the angle between the axes of the strand and the final cable changes spatially with periods of cabling pitches. The longitudinal losses depend upon the structure of the cable, the direction and pitch in each level of cabling, etc. The additional losses are evaluated in electromagnetic environments of the armature winding. The structure of the cable is discussed to minimize the total AC loss under a stability condition.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Effect of the MMA content on the emulsion polymerization process and adhesive properties of poly(BA‐<i>co</i>‐MMA‐<i>co</i>‐AA) latexes (2011)

Abstract In the past work, the shear resistance of pure poly( n ‐butyl acrylate) was low, even incorporation of inorganic filler, silica in the composition. It is well‐known that the copolymerization of n ‐butyl acrylate (BA) with methyl methacrylate (MMA) will increase the glass transition temperature, and enhance the shear resistance of acrylic polymers. In the current work, the preparation of a series of acrylic water‐borne pressure‐sensitive adhesives (PSAs) with the controlled composition and structure for the copolymerization of BA and acrylic acid (AA) with different MMA contents, poly(BA‐ co ‐MMA‐ co ‐AA) was reported and its effects on adhesive properties of the latices were investigated. The latices of poly(BA‐ co ‐MMA‐ co ‐AA) were prepared at a solid content of 50% by two‐stage sequential emulsion polymerization, and this process consisted of a batch seed stage giving a particle diameter of 111 nm, which was then grown by the semicontinuous addition of monomers to final diameter of 303 nm. Dynamic light scattering (DLS) was used to monitor the particle diameters and proved that no new nucleation occurred during the growth stage. Copolymerization of BA with MMA raised the glass transition temperature ( T g ) of the soft acrylic polymers, and had the effect of improving shear resistance, while the loop tack and peel adhesion kept relatively high. The relationship between pressure‐sensitive properties and molecular parameters, such as gel content and molecular weight, was evaluated. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011
Thermal Management of Electronic Components with Dielectric Liquids. (1993)

During the 1980s, direct liquid cooling emerged as one of the most promising thermal management techniques for electronic systems. Many observers believe that, later in this decade, direct liquid cooling with inert, dielectric liquids will become the method of choice for the thermal management of advanced computers. A clear understanding of the available empirical data and relevant heat transfer theories is an essential prerequisite for successful application of this technique. Following a brief survey of electronic packaging trends, attention is turned to the many options in direct liquid cooling and to the selection of coolants for electronic systems. Next, single-phase natural- and forced-convection, including impinging and streaming flow, are reviewed and the best available correlations presented. Ebullient heat transfer is discussed in depth, with a detailed exploration of boiling incipience, fully-established boiling, and critical heat flux for these highly-wetting liquids. Closing remarks focus on the prospects for the widespread implementation of direct liquid cooling in the electronic industry.
Microexplosions of multicomponent drops in spray flames (2022)

Experimental investigations of in-flight droplet microexplosions (μ-explosions) during flame spray pyrolysis and corresponding single drop experiments are carried out. High-speed shadowgraphy recordings with an iron nitrate-based precursor spray flame revealed the occurrence of distinct μ-explosions in high frequencies during the synthesis of iron oxide nanoparticles. This finding may lay the foundation for the investigation of the role and relevance of μ-explosions on the production and formulation of functional nanoparticle with distinct properties.
A stereospecific route to aziridinomitosanes: the synthesis of novel mitomycin congeners (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA stereospecific route to aziridinomitosanes: the synthesis of novel mitomycin congenersSamuel Danishefsky, Ellen M. Berman, Marco Ciufolini, Sarah Jane Etheredge, and Brigitte E. SegmullerCite this: J. Am. Chem. Soc. 1985, 107, 13, 3891–3898Publication Date (Print):June 1, 1985Publication History Published online1 May 2002Published inissue 1 June 1985https://pubs.acs.org/doi/10.1021/ja00299a022https://doi.org/10.1021/ja00299a022research-articleACS PublicationsRequest reuse permissionsArticle Views963Altmetric-Citations67LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Adaptive fuzzy observer and robust controller for a 2-DOF robot arm (2012)

Recently, adaptive fuzzy observers have been introduced that are capable of estimating uncertainties along with the states of a nonlinear system represented by an uncertain Takagi-Sugeno (TS) model. In this paper, we use such an adaptive observer to estimate the uncertainties in the state matrices of a two-degrees-of-freedom robot arm model. The TS model of the robot arm is constructed using the sector nonlinearity approach. The estimates are used in updating the model, and the updated model is used to design a controller for the robot arm. We analyze the improvement in the achievable controller performance when using the adaptive observer.
Histamine dihydrochloride (subcutaneous) Maxim. (2004)

Maxim is developing a subcutaneous formulation of histamine dihydrochloride (Ceplene, formerly known as Maxamine) for use as an adjuvant with interleukin (IL)-2 therapy for the potential treatment of metastatic melanoma, hepatitis C virus infection, acute myelogenous leukemia and renal cell carcinoma. In October 2002, the compound was in phase III trials for metastatic melanoma in Europe, Australia, Canada, Israel and the US. In November 2003, Maxim submitted an MAA to the EMEA for malignant melanoma in combination with IL-2.
Linear analysis of poststall gyrations (1980)

The poststall gyrations of a high-performance aircraft are investigated by approximating the equations of motion with a linear mathematical model. Equilibrium poststall spin conditions are determined, which are not limited to small angles or spin rates and are used as reference conditions about which the linear model is developed. As a result, complete coupling between lateral and longitudinal motions is retained. Three aerodynamic models are evaluated using this linear analysis. These models include pure rotary derivatives obtained from VPI&SU stability tunnel, forced-oscillation data obtained from NASA tests, and a combination of the two which separates the unsteady and pure rotary derivatives. Results indicate that this last model gives better predictions of aircraft motion during poststall gyrations at high angles of attack and large sideslip angles. Comparisons are made with full-scale flight test results.