gebhart/patrepeval huggingface dataset:
Towards Selective Ethylene Tetramerization (2010)

Und die magische Zahl ist …︁ 4! Eine große Menge an oligomerfreiem 1-Octen (99.9 %) wurde aus Ethylen bei der Bildung von Polyethylenwachs mithilfe eines Chromkatalysators erhalten (siehe GC-MS-Chromatogramm; die drei weiteren wesentlichen Signale stammen von Methanol (zum Abbrechen der Reaktion), Ethylacetat (Nadelreinigungsmittel) und Toluol (Solvens)). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Glass-like Signatures in the Dynamic Rheology of Particle-Filled Polymers (2022)

Strain amplitude (γ) effects on the time-dependent dynamic viscosity of percolated particle networks in a filled polymer are shown to mirror temperature effects on volume relaxation in nonequilibrium glasses, consistent with the jamming phase diagram concept. This is demonstrated with an uncrosslinked polymer nanocomposite system based on natural rubber reinforced with N121 carbon black (CB) particles that was evaluated with oscillatory shear rheometry. This CB-filled rubber displayed the glass-like kinetic signatures of nonequilibrium relaxation, asymmetry of approach, and the memory/crossover effect in experiments involving strain amplitude jumps comparable to temperature-jump experiments that are used to study glass-forming materials. However, the asymmetry of approach showed a slower relaxation for the γ down-jump relative to the up-jump, which is opposite to the classic temperature jump experiments on glasses. The particle networking process, commonly called filler flocculation, was also investigated as a function of filler volume fraction (ϕ), and a new definition of the percolation threshold emerged from these results. The critical ϕ where flocculation diminished to zero was identified from the ϕ-dependent data and matched well the percolation threshold separately determined from electrical resistivity measurements on crosslinked specimens.
Strained n-Channel FinFETs Featuring <i>In Situ</i> Doped Silicon–Carbon $(\hbox{Si}_{1 - y}\hbox{C}_{y})$ Source and Drain Stressors With High Carbon Content (2008)

Phosphorus <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">in</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">situ</i> doped (Si <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">1-y</sub> C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">y</sub> ) films (SiC:P) with substitutional carbon concentration of 1.7% and 2.1% were selectively grown in the source and drain regions of double-gate -oriented (110)-sidewall FinFETs to induce tensile strain in the silicon channel. <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">In</i> <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">situ</i> doping removes the need for a high-temperature spike anneal for source/drain (S/D) dopant activation and thus preserves the carbon substitutionality in the SiC:P films as grown. A strain-induced enhancement of 15% and 22% was obtained for n-channel FinFETs with 1.7% and 2.1% carbon incorporated in the S/D, respectively.
Metodo Supervisionado de Classificacao e Identificacao de Padroes de Pele em Imagens e Videos (2011)

Neste artigo e apresentado um metodo supervisionado de classificacao e identificacao de padroes de pele em sequencias de video. O usuario treina o sistema atraves da selecao de padroes tipicos de pele em um determinado frame, que sera utilizado como referencia na construcao de uma metrica de distancia nao-linear. Neste processo de aprendizado o otimo global e indutivamente obtido atraves da distancia polinomial de Mahalanobis, extraindo as caracteristicas nao-lineares dos padroes de pele. Estas caracteristicas nao-lineares sao entao utilizadas para classificar os frames capturados de uma camera, identificando todos os padroes de pele e nao-pele na cena. Foi adotada uma estrategia que possibilita ao metodo ser executado em tempo real logo apos algumas iteracoes. O metodo de classificacao foi comparado em relacao a norma vetorial (L 2 ) e distancia de Mahalanobis, demonstrando uma melhor classificacao para os padroes de pele.
On Logical Constraints in Logic Programming. (1994)

In this note we will investigate a form of logic programming with constraints. The constraints that we consider will not be restricted to statements on real numbers as in CLP(R), see [9] or on other fixed constraint domain (see the recent review article of Jaffar and Maher [10] for an excellent presentation of the issues in Constraint Logic Programming. The paper of Jaffar and Maher has an extensive bibliography so to save space we will quote only a restricted number of papers in the area). Instead our constraints will be arbitrary global constraints. The basic idea is that the applicability of a given rule is not predicated on the fact that individual variables satisfy certain constraints, but rather on the fact that the least model of the set rules that are ultimately applicable satisfy the constraint of the rule. Thus the role of clauses will be slightly different than in the usual Logic Programming with constraints. In fact, the paradigm we present is closely related to stable mode...
Neurotrophin-3 Regulates Synapse Development by Modulating TrkC-PTPσ Synaptic Adhesion and Intracellular Signaling Pathways (2016)

In this study, we present several lines of experimental evidences to support the conclusion that neurotrophin-3 (NT-3) modulates the synaptic adhesion pathway involving neurotrophin receptor tyrosine kinase C (TrkC) and presynaptic protein tyrosine phosphatase σ (PTPσ) in a bidirectional manner at excitatory synapses. NT-3 acts in concentration-independent manner to facilitate TrkC-mediated presynaptic differentiation, whereas it acts in a concentration-dependent manner to exert differential effects on TrkC-mediated organization of postsynaptic development. We further investigated TrkC extracellular ligand binding, intracellular signaling pathways, and kinase activity in NT-3-induced synapse development. Last, we found that interneuronal differences in TrkC levels regulate the synapse number. Overall, these results suggest that NT-3 functions as a positive modulator of synaptogenesis involving TrkC and PTPσ.
Collagen analogs with phosphorylcholine are inflammation-suppressing scaffolds for corneal regeneration from alkali burns in mini-pigs (2021)

The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection is heightened. Here, we show that bioengineered, fully synthetic, and robust corneal implants can be manufactured from a collagen analog (collagen-like peptide-polyethylene glycol hybrid, CLP-PEG) and inflammation-suppressing polymeric 2-methacryloyloxyethyl phosphorylcholine (MPC) when stabilized with the triazine-based crosslinker 4-(4,6-Dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride. The resulting CLP-PEG-MPC implants led to reduced corneal swelling, haze, and neovascularization in comparison to CLP-PEG only implants when grafted into a mini-pig cornea alkali burn model of inflammation over 12 months. Implants incorporating MPC allowed for faster nerve regeneration and recovery of corneal sensation. CLP-PEG-MPC implants appear to be at a more advanced stage of regeneration than the CLP-PEG only implants, as evidenced by the presence of higher amounts of cornea-specific type V collagen, and a corresponding decrease in the presence of extracellular vesicles and exosomes in the corneal stroma, in keeping with the amounts present in healthy, unoperated corneas.
Synthesis, hydrolysis over silica column, anticancer, anti-inflammatory and analgesic activity evaluation of some pyridine and pyrazine derivatives (2005)

Various 3,4-diaryl-2-iminothiazolines la-s have been condensed with 4-cyanopyridine and 2-cyanopyrazine by refluxing in methanol for about 16 hr to give corresponding 3,4-diaryl-2-imino-N-(4'-pyridyliminomethyl)-4-thiazoline (2a-k, n-p) and 3, 4-diaryl-2-imino-N-(2'-pyrazinyliminomethyl)-4-thiazoline (3a-m, q-s) derivatives. In some cases when these pyridyl and pyrazinyl derivatives are purified by column chromatography over silica gel these compounds get hydrolysed to give corresponding 3,4-diaryl-2-imino-N-(4'-carbonylpyridyl)-4-thiazoline (2o,p) and 3,4-diaryl-2-imino-N-(2'-carbonylpyrazinyl)-4-thiazoline (3q-s) derivatives. The structures of all synthesized compounds have been confirmed by spectroscopic methods. Compounds 2a-c,e-h,k,n,p, 3a-i and 31,m,q are screened for anticancer activity against a small panel of six human cancer cell lines consisting of prostate (DU 145) colon (HT 29) breast (MCF 7) breast (MCF 7/ADR), CNS (U 251) and lung large (NCIH 460) tumors. Best GI 5 0 values are shown by 3f, 11.5 μM (prostate tumor, cell line DU 145), 3f, 1.0 μM (colon tumor, cell line HT 29), 2n, 6.2μM (breast tumor, cell line MCF 7), 2p, 4.8μM (breast tumor, cell line MCF 7/ADR), 2p, 6.3μM (CNS tumor, cell line U 251) and 3f, 0.9 μM (lung large carcinoma, cell line NCIH 460) respectively. Compound 3f has shown good anticancer activity against three cancer cell lines, whereas compounds 2n and 2p against one and two cancer cell lines respectively. Antiinflammatory activity evaluation of 2a-k,n,o,p, 3a-m and 3q,r,s has been carried out and compounds 2a-h, 2j, 2o,p, 3a,b,c,g,m and 3r showed 13, 32.5, 48.8, 6.5, 13.9, 7.0, 4.3, 16.6, 20.0, 17.3, 27.7, 16.2, 18.4, 34.7, 15.6, 24.0 and 4.7% activity, respectively, at 100mg/kg p.o. Analgesic activity, evaluation of 2a-k,n,o,p, 3a-m and 3q,r,s indicates that these compounds possess 50, 25,75, 25, 50, 75, 50, 50, 25, 0.0, 50, 50, 0.0, 75, 50, 25, 25, 25, 75, 0.0, 25, 25, 25, 50, 50, 75, 25, 50, 75 and 50% analgesic activity at 100mg/kg p.o.
Advances in Hot-Structure Development (2006)

The National Aeronautics and Space Administration has actively participated in the development of hot structures technology for application to hypersonic flight systems. Hot structures have been developed for vehicles including the X-43A, X-37, and the Space Shuttle. These trans-atmospheric and atmospheric entry flight systems that incorporate hot-structures technology are lighter weight and require less maintenance than those that incorporate parasitic, thermal-protection materials that attach to warm or cool substructure. The development of hot structures requires a thorough understanding of material performance in an extreme environment, boundary conditions and load interactions, structural joint performance, and thermal and mechanical performance of integrated structural systems that operate at temperatures ranging from 1500 C to 3000 C, depending on the application. This paper will present recent advances in the development of hot structures, including development of environmentally durable, high temperature leading edges and control surfaces, integrated thermal protection systems, and repair technologies. The X-43A Mach-10 vehicle utilized carbon/carbon (C/C) leading edges on the nose, horizontal control surface, and vertical tail. The nose and vertical and horizontal tail leading edges were fabricated out of a 3:1 biased, high thermal conductivity C/C. The leading edges were coated with a three-layer coating comprised of a SiC conversion of the C/C, followed by a CVD layer of SiC, followed by a thin CVD layer of HfC. Work has also been performed on the development of an integrated structure and was focused on both hot and warm (insulated) structures and integrated fuselage/tank/TPS systems. The objective was to develop integrated multifunctional airframe structures that eliminate fragile external thermal-protection systems and incorporate the insulating function within the structure. The approach taken to achieve this goal was to develop candidate hypersonic airframe concepts, including structural arrangement, load paths, thermal-structural wall design, thermal accommodation features, and integration of major components, optimize thermalstructural configurations, and validate concepts through a building block test program and generate data to improve and validate analytical and design tools.
Distributed Radio Coverage Optimization in Enterprise Femtocell Networks (2010)

Radio coverage optimization is a key element in improving the overall performance of femtocell cellular networks. Owing to the increased size and complexity of femtocell networks, there is an imperative need to develop decentralized coverage optimization algorithms, which is a highly challenging task as these algorithms have to work without global information and coordinated central control of network nodes. In this paper, we consider a deployment scenario of a group of N femtocells in an enterprise environment and propose a decentralized algorithm for joint femtocell coverage area optimization. The algorithm updates the femtocell's pilot Tx power only and serves to balance the user load amongst the collocated femtocells as well as minimizing the coverage holes and pilot Tx power. Compared to the fixed pilot Tx power allocation, the algorithm introduces an improvement of approximately 18% in terms of supported user traffic, in addition to a significant reduction of pilot leakage to neighboring cells.
Manipulation of polyketide biosynthesis for new drug discovery (2000)

Modular polyketide synthases (PKS) are large multifunctional proteins which direct the condensation of activated short chain carboxylic acids into products of defined length and functionality using a dedicated set of active sites, or module, for each step in the polymerization. The structure of the product is directly related to the number, content and sequence of modules in a PKS. Technology is described which allows the rational manipulation of the biosynthesis of these compounds and enables the generation of specific novel polyketide structures. Examples of polyketide drugs whose structures may be manipulated using this technology are given.
Isolation and characterization of a ribonuclease from human leukemic blood cells specific for ribonucleic acid of ribonucleic acid-deoxyribonucleic acid hybrid molecules (1975)

A ribonuclease that specifically hydrolyzes RNA in RNA. DNA hybrids has been purified more than 100-fold from human acute leukemic white blood cells. The molecular weight of this enzyme has been estimated as 80,000 by glycerol gradient centrifugation. It requires Mg-2plus for activity and is inhibited by N-ethylmaleimide. The optimum activity is observed at pH 8 (37 DEGREES). It is a heat-labile protein, t 1/2 at 50 degrees being 2 min. Among the substrates examined, (A)n X (dT)m, (I)n X (DC)m, and PHIX-174 DNA X RNA were hydrolyzed efficiently. (U)n X (dA)m showed a slight substrate activity, while (c) n X (dG) m and (G)n X (dC)m were not significantly hydrolyzed. The enzyme is an endonuclease and does not require RNA ends in the substrate molecule. It is capable of converting more than 95% of the RNA portions in hybrid substrates into acid-soluble products which are mono- and oligonucleotides terminated in 3'-OH and 5'-phosphate.
Incorporating bazedoxifene/conjugated estrogens into the current paradigm of menopausal therapy (2012)

Many women experience bothersome vasomotor and vaginal symptoms during the menopausal transition. Decreasing levels of estrogens during menopause are also associated with reduced bone density and an increased risk of osteoporosis. Combined estrogen/progestin therapy (hormone therapy) effectively treats menopausal symptoms and prevents bone loss, but has been associated with some safety and tolerability concerns. A novel menopausal therapy is the tissue selective estrogen complex, which pairs a selective estrogen receptor modulator with one or more estrogens. In preclinical studies, the tissue selective estrogen complex partnering bazedoxifene (BZA) with conjugated estrogens (CE) antagonized stimulation of breast and endometrial tissue, reduced vasomotor instability, and preserved bone mass in rat and mouse models. The specific attributes seen with BZA/CE were different from those observed with other selective estrogen receptor modulator/estrogen pairings. BZA/CE has undergone clinical evaluation in the Phase III Selective estrogens, Menopause, And Response to Therapy (SMART) trials in postmenopausal women with an intact uterus. Of the various doses of BZA/CE evaluated, BZA 20 mg/CE 0.45 mg and 0.625 mg were associated with a low incidence of endometrial hyperplasia (<1%) similar to placebo, and showed significant improvements in hot flushes and vulvar/vaginal symptoms and increases in bone mineral density. BZA 20 mg/CE 0.45 mg and 0.625 mg were associated with a low incidence of breast-related adverse events and demonstrated no difference from placebo in age-related changes in mammographic breast density. Both BZA/ CE doses showed a favorable tolerability profile, with no increases in uterine bleeding or breast tenderness, and had positive effects on metabolic parameters and quality of life. BZA/CE may be a promising alternative to hormone therapy for the treatment of menopausal symptoms and prevention of osteoporosis in nonhysterectomized postmenopausal women.
Quantification of Zinc Atoms in a Surface Alloy on Copper in an Industrial‐Type Methanol Synthesis Catalyst (2014)

Abstract Methanol has recently attracted renewed interest because of its potential importance as a solar fuel. 1 Methanol is also an important bulk chemical that is most efficiently formed over the industrial Cu/ZnO/Al 2 O 3 catalyst. The identity of the active site and, in particular, the role of ZnO as a promoter for this type of catalyst is still under intense debate. 2 Structural changes that are strongly dependent on the pretreatment method have now been observed for an industrial‐type methanol synthesis catalyst. A combination of chemisorption, reaction, and spectroscopic techniques provides a consistent picture of surface alloying between copper and zinc. This analysis enables a reinterpretation of the methods that have been used for the determination of the Cu surface area and provides an opportunity to independently quantify the specific Cu and Zn areas. This method may also be applied to other systems where metal–support interactions are important, and this work generally addresses the role of the carrier and the nature of the interactions between carrier and metal in heterogeneous catalysts.
Switching on superferromagnetism (2019)

Electric-field control of magnetism has emerged as a potential approach for low-power consumption spintronics. Although recent results in multiferroic systems have shown the possibility to manipulate the magnetic state of magnetic materials deposited on ferroelectric substrates by means of electric fields, the resulting magnetic state is multidomain in nature. For real multiferroic devices to become a true single magnetic domain state, lower dimensionality is required. In this work, the authors show, for an assemble of iron nanograins deposited on top of a BaTiO${}_{3}$ substrate, that an electric field-induced strain is capable of switching on a collective long-range ferromagnetic order (superferromagnetism) on an otherwise zero-dimensional superparamagnetic nanoparticle system. The effect, observed slightly above room temperature, holds promise for the implementation of nanoscale multiferroic systems in spin-based storage and logic architectures operating at ambient conditions.
Accurate Road Geometry Estimation for a Safe Speed Application (2006)

In Europe, a considerable part of lives lost in traffic accidents is due to inappropriate vehicle speed or headway. Excessive speed is one of the major causes of accidents on European roads, responsible for one-third of all road accidents. SASPENCE, as part of the EU founded integrated project PReVENT, is developing and evaluating an innovative system able to perform the reliable and comfortable safe speed and safe distance concept, which helps the driver to avoid dangerous situations related to excessive speed or too small headway. In this paper, the high precise reconstruction of the road geometry is discussed. This information about the road geometry is needed in the project to be able to calculate the risk of a given scenario and given speed. A sensor fusion method is proposed to combine information from a vision sensor, a radar system, digital maps, a GPS sensor and odometric sensors to one common description of the road geometry in front of the vehicle. Thereby, the sensor information is used to localize the own vehicle relative to the map data. The system has been tested using real data and the results are shown in the paper
Interferon (IFN)-α Activation of Human Blood Mononuclear Cells In Vitro and In Vivo for Nitric Oxide Synthase (NOS) Type 2 mRNA and Protein Expression: Possible Relationship of Induced NOS2 to the Anti–Hepatitis C Effects of IFN-α In Vivo (1997)

Although researchers have noted high level activation of rodent mononuclear phagocytes for nitric oxide (NO) synthase type 2 (S2) expression and NO production with a variety of agents such as interferon (IFN) gamma and endotoxin, it has been difficult to demonstrate activation of human mononuclear phagocytes. The purpose of this study was to determine if IFN-alpha serves as an activator in vitro and in vivo in humans. Treatment of normal monocytes or mononuclear cells in vitro with IFN-alpha caused a dose-dependent increase in monocyte NOS2 activity and NO production, and increased expression of NOS2 protein and mRNA expression. To determine if in vivo administration of IFN-alpha also modulated NOS2, we studied blood cells from patients with hepatitis C before and after IFN-alpha therapy. Untreated patients with chronic hepatitis C virus infection had levels of NOS activity and NOS2 antigen in freshly isolated mononuclear cells similar to those of healthy subjects, and they expressed minimal or no NOS2 mRNA. However, IFN-alpha treatment of patients with hepatitis C infection was associated with a significant elevation in mononuclear cell NOS activity, NOS2 antigen content, and NOS2 mRNA content. IFN-alpha-treated patients had significant decreases in levels of serum alanine aminotransferase and plasma hepatitis C mRNA. The degree of IFN-alpha-enhanced mononuclear cell NOS2 antigen content correlated significantly with the degree of reduction in serum alanine aminotransferase levels. Thus, IFN-alpha treatment of cells in vitro or administration of IFN-alpha to hepatitis C patients in vivo increases expression of mononuclear cell NOS2 mRNA expression, NOS activity, NOS2 antigen expression, and NO production. Since NO has been reported to have antiviral activity for a variety of viruses, we speculate that induced NO production may be related to the antiviral action(s) of IFN-alpha in hepatitis C infection.
[Effects of thrombin peptides on wound healing and proliferation and migration of normal human epidermal keratinocyte (NHEK)]. (2000)

Results of this study suggest that both thrombin and TP508 have significant actions on wound healing and NHEK proliferation and migration, which is important in wound repair.
Data Rewrite of Wavelength Channel Using Saturated SOA Modulator for WDM Metro/Access Networks with Centralized Light Sources (2002)

We propose a simple wavelength reuse technique for WDM metro/access networks with centralized light sources. Using a deeply saturated SOA modulator located in a remote node, we erase the data on a low-extinction-ratio downstream signal and modulate it with new data to generate an upstream signal.