gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of the Necine Base Platynecine from Glucose. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
IJTAG supported 3D DFT using chiplet-footprints for testing multi-chips active interposer system (2016)

In order to increase the circuit yield, 2.5D technology have been introduced to partition a single large circuit in multiple circuits, which are tested before bonding and then assembled in 3D onto a passive silicon interposer. Active interposer is nowadays envisioned in order to provide added values within the interposer and the 3D complete system. The testability of 2.5D interposers have already been well studied but no 3D DFT have already been proposed for active interposers. In this paper, a 3D Design-for-Test architecture is proposed for testing multi-chips stacked onto an active interposer. The 3D-DFT is based on a chiplet footprint architecture, allowing the modular test of any chiplets, and is implemented using IJTAG IEEE1687 standard, offering easy test pattern retargeting from chiplet pre-bond test to the 3D circuit final test. The proposed 3D-DFT architecture and the associated 3D test flow have been fully applied onto a 3D active interposer circuit prototype and used extensively to test interposer active links, interposer passive links and all embedded memory BIST engines.
Non-Cellulosic Polysaccharides from Cotton Fibre Are Differently Impacted by Textile Processing (2014)

Cotton fibre is mainly composed of cellulose, although non-cellulosic polysaccharides play key roles during fibre development and are still present in the harvested fibre. This study aimed at determining the fate of non-cellulosic polysaccharides during cotton textile processing. We analyzed non-cellulosic cotton fibre polysaccharides during different steps of cotton textile processing using GC-MS, HPLC and comprehensive microarray polymer profiling to obtain monosaccharide and polysaccharide amounts and linkage compositions. Additionally, in situ detection was used to obtain information on polysaccharide localization and accessibility. We show that pectic and hemicellulosic polysaccharide levels decrease during cotton textile processing and that some processing steps have more impact than others. Pectins and arabinose-containing polysaccharides are strongly impacted by the chemical treatments, with most being removed during bleaching and scouring. However, some forms of pectin are more resistant than others. Xylan and xyloglucan are affected in later processing steps and to a lesser extent, whereas callose showed a strong resistance to the chemical processing steps. This study shows that non-cellulosic polysaccharides are differently impacted by the treatments used in cotton textile processing with some hemicelluloses and callose being resistant to these harsh treatments.
Adsorption of multivalent ions on charged Langmuir monolayers (2007)

We have investigated the interaction between a Langmuir monolayer of C20H41NH2, a long-chain fatty amine and large, multivalent, heteropolyanions (phosphotungstic acid, PTA for short) dissolved in the aqueous subphase. By using X-ray reflectivity, surface pressure and surface potential measurements, we show that the adsorption is controlled by the electrostatic interaction between the PTA molecules and the amine film. At basic pH, the amine groups are not charged and no adsorption occurs. On the contrary, at acidic pH, the amines are positively charged. The surface pressure isotherms are markedly different in presence of PTA and the surface potential measurements reveal a reversal of the surface polarity. X-ray reflectivity gives a microscopic picture of the interfacial layer. The PTA anions are adsorbed onto the charged amine head groups as a monolayer or at most a bilayer. Changing the surface density of amines allows to control the total amount of PTA adsorbed and to vary the inorganic layer thickness.
Polymer - CuInS&lt;inf&gt;2&lt;/inf&gt; hybrid solar cells obtained by an in-situ formation route (2010)

Bulk heterojunction hybrid solar cells with a CuInS <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> -poly(p-phenylene vinylene) active layer are presented in this contribution. The acceptor phase is obtained in-situ within the matrix of the polymer by the reaction of the metal ions with the decomposition products of a sulfur source (thioacetamide) using a moderate heating step. As prepared donor-acceptor nanocomposites were used as active layers in hybrid solar cells. Structural characterization was performed using XRD and TEM methods, solar cell performance and optical properties were explored by j-V-, absorbance- and IPCE-measurements.
Running Gait Generation for Biped Robot with Horizontal Force Limit (2011)

In this paper, we propose a running gait generation method for a biped robot using the dynamics model with two foot masses, an inverted pendulum and a flywheel. The inverted pendulum and flywheel represent the horizontal motion and the bending motion of the upper body respectively. Initially the acceleration of the inverted pendulum is determined to satisfy the desired ZMP. If the horizontal ground reaction force exceeds its limit, the acceleration of the inverted pendulum is modified and the flywheel is accelerated to compensate this modification. To guarantee the continuity of gait generation, we extend previously proposed concept ``the divergent component of the motion'' to be applicable for the inverted pendulum under time-varying ground reaction force. Using this concept as the boundary condition, the current gait converges to the next cyclic gait. Compared with the boundary condition using position and velocity, proposed boundary condition requires smaller amount of modification of the desired ZMP trajectory.
Platelet-derived Growth Factor (PDGF)-induced Tyrosine Phosphorylation of the Low Density Lipoprotein Receptor-related Protein (LRP) (2002)

The low density lipoprotein receptor-related protein (LRP) functions in the catabolism of numerous ligands including proteinases, proteinase inhibitor complexes, and lipoproteins. In the current study we provide evidence indicating an expanded role for LRP in modulating cellular signaling events. Our results show that platelet-derived growth factor (PDGF) BB induces a transient tyrosine phosphorylation of the LRP cytoplasmic domain in a process dependent on PDGF receptor activation and c-Src family kinase activity. Other growth factors, including basic fibroblast growth factor, epidermal growth factor, insulin-like growth factor-1, were unable to mediate tyrosine phosphorylation of LRP. The basis for this selectivity may result from the ability of LRP to bind PDGFBB, because surface plasmon resonance experiments demonstrated that only PDGF, and not basic fibroblast growth factor, epidermal growth factor, or insulin-like growth factor-1, bound to purified LRP immobilized on a sensor chip. The use of LRP mini-receptor mutants as well as in vitro phosphorylation studies demonstrated that the tyrosine located within the second NPXY motif found in the LRP cytoplasmic domain is the primary site of tyrosine phosphorylation by Src and Src family kinases. Co-immunoprecipitation experiments revealed that PDGF-mediated tyrosine phosphorylation of LRPs cytoplasmic domain results in increased association of the adaptor protein Shc with LRP and that Shc recognizes the second NPXY motif within LRPs cytoplasmic domain. In the accompanying paper, Boucher et al. (Boucher, P., Liu, P. V., Gotthardt, M., Hiesberger, T., Anderson, R. G. W., and Herz, J. (2002) J. Biol. Chem. 275, 15507-15513) reveal that LRP is found in caveolae along with the PDGF receptor. Together, these studies suggest that LRP functions as a co-receptor that modulates signal transduction pathways initiated by the PDGF receptor.
Whole blood coagulation in children with thrombocytopenia and the response to platelet replacement, recombinant factor VIIa, and a potent factor VIIa analogue (2008)

The present study evaluated dynamic coagulation profiles, platelet aggregation, and thrombin generation in whole blood (WB) from eight children with thrombocytopenia during chemotherapy, and the haemostatic potential of platelets (+60 x 10(9)/l), recombinant factor VIIa (rFVIIa - NovoSeven), and a potent rFVIIa analogue (NN1731) both at 1 and 4 microg/ml. Dynamic WB coagulation profiles were recorded by thrombelastometry employing activation with tissue factor (TF - Innovin) at low concentrations. The baseline WB coagulation patterns were characterised by a prolonged clotting time (CT) and a pronounced reduction in clot propagation (MaxVel). WB platelet aggregation signal was five times lower in the study group compared with measurements in modelled thrombocytopenic WB from healthy volunteers. In vitro addition of fresh platelets reversed the coagulopathy. Addition of rFVIIa induced no significant changes in the thrombelastographic profile, whereas spiking with NN1731 shortened the CT significantly. The changes in WB thrombin generation reflected the changes in the MaxVel. In modeled thrombocytopenic WB from healthy individuals, both rFVIIa and NN1731 exhibited a pronounced haemostatic effect with NN1731 showing greater potency than rFVIIa. Compromised platelet function in the study group was assumingly responsible for the weakened haemostatic potential of rFVIIa as well as that of NN1731.
The relevance of Veress needle overshooting reduction; A Survey among 365 surgeons (2023)

Abstract Introduction Safe insertion of the Veress needle in laparoscopy relies on the surgeons’ technical skills in order to stop needle insertion just in time to prevent overshoot in the underlying organs. To reduce this risk, a wide variety of veress needle systems were developed with safety mechanisms that limit de insertion speed, insertion depth or decouples the driving force generated by the hand on the needle. The aim of this study is to evaluate current perceptions related to the use of Veress needles and to investigate the relevance of preventing overshooting of Veress needles among EAES members. Methods An online survey was distributed by the European Association of Endoscopic Surgery (EAES) Executive Office to all active members. The survey consisted of demographic data and 14 questions regarding the use of the Veress needle, the conducted training prior to usage, and the need for improvements. Results A total of 365 (10%) members responded coming from 58 different countries. Of the responding surgeons, 36% prefers the open method for patients with normal BMI, and 22% for patients with high BMI. Of the surgeons using Veress needle, 68% indicated that the reduction of overshoot is beneficial in normal BMI patients, whereas 78% indicated that this is beneficial in high BMI patients. On average, the members that uses the Veress needle used it for 1448 (SD 3031) times and felt comfortable on using it after 22,9 (SD 78,9) times. The average years of experience was 17,6 (SD 11,1) and the surgeons think that a maximum overshoot of 9.4 (SD 5.5) mm is acceptable before using the system safely. Conclusion This survey indicates that despite the risks, Veress needles are still being used by the majority of the laparoscopic surgeons who responded. In addition, the surgeons responded that they are interested in using a Veress needle with extra safety mechanism if it limits the risk of overshooting into the underlying structures.
Endothelial Growth Factor Receptors in Human Fetal Heart (1999)

The results demonstrate differential expression of the endothelial growth factor receptors in distinct types of vessels in the human heart. This information is useful for the understanding of their roles in physiological and pathological processes and for their diagnostic and therapeutic application in cardiovascular medicine.
Immune Response to Peptides Produced by Enzymatic Digestion of Microfibrils And Elastin of Human Lung Parenchyma (1977)

AbstractAntibodies were raised in rabbits against human lung elastic fiber and peptides derived from human lung elastin and microfibrils. Elastic fiber produced antibodies with very low liter. Elastin peptides had low immunogenicity and multiple injections of at least 100 mg per rabbit per injection were required to produce antibodies. Microfibril peptides had a much higher immunogenicity and produced antibodies with multiple injections of only 10 mg per rabbit per injection.Anti-elastic fiber serum did not react with peptides derived from microfibrils or elastin at concentrations of 5 mg or 10 mg per ml solution. At 25 mg/ml solution microfibril peptides gave a faint precipitin line in Ouchterlony double diffusion tests, but elastin peptides did not react. There was no cross reactivity between microfibril peptides and anti-elastin serum or elastin peptides and anti-microfibril serum at low concentration. At higher concentration, i.e. 25 mg/ml, some cross reactivity was observed with both antigens and both antisera, but absorption of anti-elastin serum with microfibril peptides or antimicrofibril serum with elastin peptides eliminated the cross reactivity and showed that each antigen has specific antigenic determinants which are lacking in the other. Both anti-microfibril serum and anti-elastin serum were found to be species and organ specific except for slight cross reactivity of anti-human lung elastin serum with elastin peptides of human aorta.
A New Method to Produce Superfine and Nano-Sized Fe Powders: Spark Plasma Discharge Process (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced chromosome aberrations in mouse keratinocyte cell lines: a possible genetic mechanism of tumor promotion (1985)

The effect of the tumor promoter, 12-O-tetradecanoyl-phorbol-13-acetate (TPA) on the induction of numerical and structural chromosomal aberrations, double minute chromosomes (DM) and homogeneously staining regions (HSR) was investigated in two mouse keratinocyte cell lines (HEL-30 and HEL-37) using G- and C-banded chromosomal preparations. The frequency of polyploid metaphases and of structural aberrations increased several fold during the first two cell cycles. The increase of gaps, chromatid and isochromatid breaks was accompanied by inter- and intrachromosomal exchanges, which were virtually absent in control cultures. The induction of chromosomal aberrations was similarly expressed in both cell lines at different passage levels and was largely independent of the TPA dose applied (10 −9 –10 −6 M). The non-promoting phorbolester 4-O-methyl-TPA (10 −6 M) did not produce any chromosomal aberrations above the control level. Effects were already visible within one cell cycle (24 h) after treatment and increased with longer and multiple exposure. Moreover, the TPA-induced chromosomal aberrations persisted for several days after elimination of the promoter and further cultivation of cells in fresh medium. Structural alterations were not randomly distributed but chromosomes 1 and 2 were preferentially involved in breaks, while chromosomes 1 – 3 and 9 – 13 were mainly involved in chromosomal exchanges. Chromosomes 7 and 14, which are numerically underrepresented in HEL cells, were least involved in breaks. Most interesting, the frequency of metaphases carrying DMs increased 2- to 3-fold after TPA treatment, and the alterations were partially reversible after removal of TPA. These early effects of TPA at the chromosomal level could play an essential role in the mechanism of tumor promotion and may be responsible for the observed persistence of alterations induced during the first stage of tumor promotion.
ChemInform Abstract: Indium‐Mediated Reaction of 3‐Bromo‐3,3‐difluoropropene and Bromodifluoromethylacetylene Derivatives with Aldehydes. (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Tandem Gold‐Catalyzed Dehydrative Cyclization/Diels—Alder Reactions: Facile Access to Indolocarbazole Alkaloids. (2015)

Abstract A gold‐catalyzed synthesis of cyclic 2‐oxodienes from readily prepared propargyl alcohols and the subsequent Diels—Alder reaction are reported.
A New Method for Estimating Initial Rotor Phase of Self-Excited Hybrid-Field Synchronous Motors (2008)

This paper proposes a new method for estimating properly rotor initial phase (in other words, position) of newly emerging self-excited hybrid-field synchronous motors (SelE-HFSMs), which have rotor field by both permanent magnet and diode-shorted field winding. The proposed method injects spatially rotating high-frequency voltage and detects the rotor phase directly through evaluating norm of the associated current. The method is very simple, but has a high degree of usability.
Improvement of Skin Penetration, Antipollutant Activity and Skin Hydration of 7,3′,4′-Trihydroxyisoflavone Cyclodextrin Inclusion Complex (2019)

As is known, many antioxidants from plant extracts have been used as additives in skincare products to prevent skin damage following overexposure to environmental pollutants. 7,3',4'-trihydroxyisoflavone (734THIF), an isoflavone compound, possesses various biological activities, including antioxidant, antityrosinase, photodamage protection, and anticancer effects. Unfortunately, 734THIF has poor water solubility, which limits its skin penetration and absorption, and subsequently influences its biological activity. The aim of the present study was to investigate the mechanisms for the improvement in water solubility and skin penetration of 2-hydroxypropyl-β-cyclodextrin (HPBCD) inclusion complex with 734THIF (5-7HP). We also determined its photostability, antipollutant activity in HaCaT keratinocytes, and moisturizing effect in human subjects. Our results showed that 734THIF was embedded into the lipophilic inner cavity of HPBCD and its water solubility and skin penetration were thereby improved through amorphous transformation, surface area enhancement, and hydrogen bonding formation between 734THIF and HPBCD. In addition, 5-7HP inhibited PM-induced ROS generation and then downregulated ROS-mediated COX-2 and MMP9 production and AQP-3 consumption by inhibiting the phosphorylation of MAPKs. Consequently, we suggest that 5-7HP is a safe and photostable topical ingredient to enhance the skin penetration of 734THIF and skin hydration, and therefore 5-7HP may be used as an antipollutant additive in skin care products.
Mis-spliced transcripts generate <i>de novo</i> proteins in TDP-43-related ALS/FTD (2023)

Functional loss of TDP-43, an RNA-binding protein genetically and pathologically linked to ALS and FTD, leads to inclusion of cryptic exons in hundreds of transcripts during disease. Cryptic exons can promote degradation of affected transcripts, deleteriously altering cellular function through loss-of-function mechanisms. However, the possibility of <i>de novo</i> protein synthesis from cryptic exon transcripts has not been explored. Here, we show that mRNA transcripts harboring cryptic exons generate <i>de novo</i> proteins both in TDP-43 deficient cellular models and in disease. Using coordinated transcriptomic and proteomic studies of TDP-43 depleted iPSC-derived neurons, we identified numerous peptides that mapped to cryptic exons. Cryptic exons identified in iPSC models were highly predictive of cryptic exons expressed in brains of patients with TDP-43 proteinopathy, including cryptic transcripts that generated <i>de novo</i> proteins. We discovered that inclusion of cryptic peptide sequences in proteins altered their interactions with other proteins, thereby likely altering their function. Finally, we showed that these <i>de novo</i> peptides were present in CSF from patients with ALS. The demonstration of cryptic exon translation suggests new mechanisms for ALS pathophysiology downstream of TDP-43 dysfunction and may provide a strategy for novel biomarker development.
PACED: Provenance-based Automated Container Escape Detection (2022)

The security of container-based microservices relies heavily on the isolation of operating system resources that is provided by namespaces. However, vulnerabilities exist in the isolation of containers that may be exploited by attackers to gain access to the host. These are commonly referred to as container escape attacks. While prior work has identified vulnerabilities in namespace isolation, no general container escape detection and warning system has been presented. We present Paced, a novel, realtime system to detect container-escape attacks. We define what constitutes a cross-namespace event and how such events can be used to detect a container escape attack. We develop a provenance-based approach to isolate cross-namespace events and propose a rule—privileged_flow—to detect attacks on Docker and Kubernetes environments. We evaluate our detection method on a suite of contemporary CVEs with container escape exploits, bad container configurations, and benchmarks. Paced achieves near-perfect accuracy with no false negatives. We release our implementation and datasets as free, open-source software.
Neuronal plasticity and macular edema (2008)

Abstract Purpose The aim of this study is to analyze the retinal structure of the macula of patients having recovered from ME due to perfused retinal vein occlusion(RVO) and compare it to histology of experimental RVO in rats. Methods In 26 patients with perfused RVO having recovered from ME, averaged high resolution OCT cross scans were acquired. The aspect of retinal layering was analyzed and compared to that of fellow eyes. In parallel, the retinal structure of rats subjected to transient RVO was analyzed by immunohistochemistry and electron microscopy. Results All eyes had a normal macular profile. In 7 out of 14 eyes with normal visual function, disorganization of the layers presumably corresponding to the outer plexiform layer(OPL) was detected associated with variable thinning of the outer and inner nuclear layer (ONL, INL). Loss of central vision occurred was present only when disruption of the OS reflectance was apparent. In rats, a similar profile of OPL dizorganisation and ONL and INL thinning was observed. Electron microscopy objectivated synaptic migration into the ONL. Conclusion Neuroglial plasticity is challenged during macular edema. Remodeling of retinal layers may be detected by OCT even when visual acuity is normal. Post‐RVO ME neuroglial remodeling initially affects the OPL. Loss of cone OS is a crucial milestone during the course of ME, being the first event leading to irreversible visual loss. The fact that OPL damage precede cone OS loss may suggest that deafferentation participates to cone OS loss.
Lessons learnt from the first efficacy trial of a new infant tuberculosis vaccine since BCG (2013)

The clinical, regulatory and research environment for modern efficacy trials of new TB vaccines are substantially different to that when BCG vaccine was first evaluated in infants. Future infant TB vaccine trials will need to allocate sufficient resources and optimise operational efficiency. A stringent TB case definition is necessary to maximize specificity, and TB case accrual must be monitored closely.
Effect of Indirect Neural Decompression Through Oblique Lateral Interbody Fusion for Degenerative Lumbar Disease (2014)

3.