gebhart/patrepeval huggingface dataset:
Coupled Flight Simulator and CFD Calculations of Ship Airwake using Kestrel (2015)

The coherent vortical wakes of the flow past Navy ships can pose a flight risk to fixed and rotary wing aircraft landing on the deck. Safety can be greatly enhanced by using realistic flight simulators to train pilots. However, flight simulators typically use atmospheric models of turbulence that do not adequately represent the coherent wakes present near ships. Recently air wakes have been calculated using CFD and fed into flight simulators to enhance realism. However, this approach provides only one-way coupling, ignorning the effect of the aircraft on the airwake, such as the effect of the superstructure in modifying ground effect. Also the airwake’s effect on the air vehicle was necessarily a linear model based on a small number of discrete sample points around the aircraft. The current effort successfully couples the CFD solver, HPCMP CREATETM–AV Kestrel, to the U.S. Navy flight simulation executive, CASTLE, resulting in a fully coupled simulation of the rotorcraft and ship airwake. The primary means of coupling is through the rotor blade element model hosted within CASTLEand implemented as a force source in Kestrel. The aerodynamic forces are calculated by CASTLEbased on the Kestrel calculated velocities at the rotor. The coupling takes advantage of the modular nature of Kestrel, using a newly developed component that communicates through named pipes with CASTLE. The paper will present a fully coupled hover case, compared to CASTLE-only simulations, bladeelement momentum disk simulations, and resolved rotor blades to validate the rotor model. Additionally a forward flight case will be presented with the pilot model coupled. Finally, an approach to ship case will be examined.
Free Article from Gene Networks and microRNAs Implicated in Aggressive Prostate Cancer (2023)

Free Article from Gene Networks and microRNAs Implicated in Aggressive Prostate Cancer
<i>Staphylococcus aureus</i>Secreted Toxins and Extracellular Enzymes (2019)

<i>Staphylococcus aureus</i> is a formidable pathogen capable of causing infections in different sites of the body in a variety of vertebrate animals, including humans and livestock. A major contribution to the success of <i>S. aureus</i> as a pathogen is the plethora of virulence factors that manipulate the host's innate and adaptive immune responses. Many of these immune modulating virulence factors are secreted toxins, cofactors for activating host zymogens, and exoenzymes. Secreted toxins such as pore-forming toxins and superantigens are highly inflammatory and can cause leukocyte cell death by cytolysis and clonal deletion, respectively. Coagulases and staphylokinases are cofactors that hijack the host's coagulation system. Exoenzymes, including nucleases and proteases, cleave and inactivate various immune defense and surveillance molecules, such as complement factors, antimicrobial peptides, and surface receptors that are important for leukocyte chemotaxis. Additionally, some of these secreted toxins and exoenzymes can cause disruption of endothelial and epithelial barriers through cell lysis and cleavage of junction proteins. A unique feature when examining the repertoire of <i>S. aureus</i> secreted virulence factors is the apparent functional redundancy exhibited by the majority of the toxins and exoenzymes. However, closer examination of each virulence factor revealed that each has unique properties that have important functional consequences. This chapter provides a brief overview of our current understanding of the major secreted virulence factors critical for <i>S. aureus</i> pathogenesis.
Ocular Mucin Visualization by Confocal Laser Scanning Microscopy (2008)

In summary, we present a method of objectively identifying those individuals with problems associated with either a lack of mucins or a reduction in the distribution of these proteins over the ocular surface.
Optical Nanoantennas For High-Efficient Ultra-Thin Solar Cells (2010)

We propose new concepts for light trapping in ultra-thin solar cells. It is shown that optical nanoantennas can lead to broadband absorption in 30 nm-thick GaAs solar cells, with 14.5% energy conversion efficiency.
Bone Mineral, Histomorphometry, and Body Composition in Adults with Growth Hormone Receptor Deficiency (1998)

Growth hormone (GH) and insulin-like growth factor I (IGF-I) deficiencies have been associated with osteopenia in both children and adults. To examine the effects of growth hormone resistance on bone mineral and body composition, we studied 11 adults (mean age 30 years) with growth hormone receptor deficiency (GHRD, Laron syndrome) and 11 age- and gender-matched controls from Southern Ecuador. Bone mineral and body composition were determined by dual-energy X-ray absorptiometry. Bone physiology was assessed with biochemical markers of bone turnover and dynamic bone histomorphometry. Bone size and body composition differed markedly between subjects with GHRD and controls. Affected adults were 40 cm shorter than controls, had significantly less lean body mass, and had increased percent body fat. Bone mineral content and density (BMD) at the spine, femoral neck, and whole body were significantly lower in adults with GHRD than in controls. Mean BMD Z scores were -1.5 to -1.6 at all sites in affected women and -2.2 to -2.3 in men with GHRD. Estimated volumetric bone density (BMAD) at the spine and femoral neck, however, was not reduced in GHRD. Spine BMAD was 0.210 +/- 0.025 versus 0.177 +/- 0.021 for affected women versus controls (p < 0.05) and 0.173 +/- 0.018 versus 0.191 +/- 0.025 for men with GHRD versus normals (p = 0.31). Urinary pyridinoline concentrations were significantly greater in adults with GHRD than in controls, while type I collagen C-telopeptide breakdown products and markers of bone formation did not differ. Differences in histomorphometry were limited to a reduction in trabecular connectivity; bone volume and formation rate were similar to controls. These data confirm the importance of the GH/IGF axis in regulating bone size and body composition. The contribution of these peptides to the acquisition and maintenance of bone mineral is less certain since volumetric bone density was preserved despite low levels of IGF-I and IGFBP-3 associated with GH resistance.
Hair motion cloning from cartoon animation sequences (2006)

Abstract This paper describes a new approach to create cartoon hair animation that allows users to use existing cel character animation sequences. We demonstrate the generation of cartoon hair animation accentuated in ‘anime‐like’ motions. The novelty of this method is that users can choose the existing cel animation of a character's hair animation and apply environmental elements such as wind to other characters with a three‐dimensional structure. In fact, users can reuse existing cartoon sequences as input to endow another character with environmental elements as if both characters exist in the same scene. A three‐dimensional character's hair motions are created based on hair motions from input cartoon animation sequences. First, users extract hair shapes at each frame from input sequences from which they then construct physical equations. ‘Anime‐like’ hair motion is created by using these physical equations. Copyright © 2006 John Wiley &amp; Sons, Ltd.
Excitatory/inhibitory balance emerges as a key factor for RBN performance, overriding attractor dynamics (2023)

Reservoir computing provides a time and cost-efficient alternative to traditional learning methods. Critical regimes, known as the "edge of chaos," have been found to optimize computational performance in binary neural networks. However, little attention has been devoted to studying reservoir-to-reservoir variability when investigating the link between connectivity, dynamics, and performance. As physical reservoir computers become more prevalent, developing a systematic approach to network design is crucial. In this article, we examine Random Boolean Networks (RBNs) and demonstrate that specific distribution parameters can lead to diverse dynamics near critical points. We identify distinct dynamical attractors and quantify their statistics, revealing that most reservoirs possess a dominant attractor. We then evaluate performance in two challenging tasks, memorization and prediction, and find that a positive excitatory balance produces a critical point with higher memory performance. In comparison, a negative inhibitory balance delivers another critical point with better prediction performance. Interestingly, we show that the intrinsic attractor dynamics have little influence on performance in either case.
GLUCOCORTICOIDS IN RHEUMATOID ARTHRITIS—MEDIATORS AND MECHANISMS (1993)

GLUCOCORTICOIDS IN RHEUMATOID ARTHRITIS—MEDIATORS AND MECHANISMS Get access E. F. MORAND, E. F. MORAND Inflammation Research Group, Bath Institute for Rheumatic DiseasesTrim Bridge, Bath BA1 1HD Search for other works by this author on: Oxford Academic PubMed Google Scholar N. J. GOULDING N. J. GOULDING Inflammation Research Group, Bath Institute for Rheumatic DiseasesTrim Bridge, Bath BA1 1HD Correspondence to N. J. Goulding. Department of Rheumatology. The Medical College of St Bartholomew's Hospital. London ECIM 6BQ Search for other works by this author on: Oxford Academic PubMed Google Scholar Rheumatology, Volume 32, Issue 9, September 1993, Pages 816–819, https://doi.org/10.1093/rheumatology/32.9.816 Published: 01 September 1993 Article history Received: 05 September 1992 Accepted: 18 November 1992 Published: 01 September 1993
Variations in Chemical Composition of Human Glomerular and Tubular Basement Membranes with Age and Disease (1980)

A graded sieving procedure was used to isolate glomeruli and tubules from renal cortex of men of premature age up to 80 years and of 4 patients suffering from Zellweger syndrome, congenital nephrotic syndrome, polycystic renal disease or diabetes mellitus. Glomerular and tubular basement membranes (GBM and TBM, respectively) were obtained with a detergent procedure. Purity of basement membrane preparations was controlled with light and electron microscopy and by estimating total phosphorus content. Amino acid and carbohydrate composition of the basement membranes were determined and statistically evaluated. Comparison of GBM and TBM from the same kidneys showed at all ages that GBM contains more 3-hydroxyproline, neuraminic acids and mannose. These differences may contribute to the different immunogenic properties of the two basement membranes reported in the literature. Significant changes with age in the chemical composition were found, suggesting that the proportion of collagenous peptide moieties increases and that of noncollagenous peptide moieties decreases with age in both GBM and TBM. In addition, the hydroxylation grade of proline and lysine increases significantly with age reaching an adult level for GBM after 4-6 months of age and for TBM at late childhood. The age-related changes in basement membrane composition may influence functional properties of these extracellular renal structures. The chemical composition of GBM and/or TBM of the 4 patients showed some differences in comparison to control preparations from persons with ages approximating that of the patients.
Nelson A. Mason and Matthew Forney Steele Collection, 1885-1960 (2012)

Unpublished written histories, including "Chief Sitting Bull's Latter Days," by Nelson A. Mason and "The Death of Sitting Bull, a Reminiscence," by M.F. Steele; legal agreement between Sitting Bull and Buffalo Bill's Wild West Show concerning his appearance in 1885; newspaper clippings; and other papers.
Development of ABT-806i, a Kit-formulated 111In-ABT-806 antibody directed to EGFR for tumor imaging (2013)

396 Objectives ABT-806 is a humanized antibody targeting a unique epitope on EGFR only available for binding when EGFR is overexpressed, activated, or when the EGFRvIII mutation is present. This property allows for a higher tumor to normal tissue contrast and thus enables ABT-806 for payload delivery. We have therefore developed 111In-labeled ABT-806 (ABT-806i) for SPECT imaging of EGFR positive tumors. Methods The ABT-806 antibody was conjugated with either DTPA or CHX-A’-DTPA and used to generate 111In-labeled ABT-806 (ABT-806i) which was characterized to evaluate its radiochemical features and its relative tumor-specific binding properties using nanoSPECT/CT image quantification. Results Selective tumor targeting of 111In-labeled ABT-806 (ABT-806i) was demonstrated in both wild-type EGFR overexpressing tumor xenografts (11 ± 2.1 %ID/cc) and EGFRvIII positive tumor xenografts, 21.5 ± 4.3%ID/cc in flank and 75.1 ± 11.3 %ID/cc as orthotopic glioma. The specific tumor uptake was inhibited gradually by co-dosing increasing concentrations of unlabeled ABT-806 antibody, from which a tumor occupancy curve was generated to estimate the dose for 50% tumor saturation as 13 mg/kg in flank xenografts. ABT-806 conjugated to CHX-A’-DTPA was GMP manufactured as a formulated kit. The labeling efficiency with sterile 111In was consistently higher than 95% for the instant preparation. The immunoreactive fraction was 0.8 ± 0.06 and the product is stable for 5 days and the prepared ABT-806i retained the favorable in vivo biodistribution and tumor targeting features. Conclusions These features render ABT-806i a promising imaging agent currently under clinical validation for characterization of tumor EGFR status. Research Support Abbott Labs
Jean Bodin’s Daemon and his Conversion to Judaism (2017)

In the Dernonomanie Jean Bodin describes in vivid and circumstantial detail the apparition of a daemon to an unnamed acquaintance. As long ago as 1910 von Bezold argued that the acquaintance was Bodin himself. His extremely thorough article has had surprisingly little impact on the interpretation of Bodin's thought. Bodin refers very favourably to Calvin, Luther and Melanchthon. His historiography is inspired in part by Protestant historians and he always quotes the psalms in Protestant translations. Bodin specifically identifies the natural and divine law, which he normally couples in the one phrase. In the year 1567 Bodin first seems to have become involved in the investigation of daemonic phenomena. A relevant passage occurs in a chapter of the Demonomanie which considers forms of protection against magic. Bodin argues at some length that justice should be implemented harmonically. He believes that this harmonic justice is exemplified only in the Law of God, and in Hebraic legislation.
Guanosine Triphosphate Binding to β‐Subunit of Tubulin in Alzheimer's Disease Brain: Role of Microtubule‐Associated Protein τ (1995)

In Alzheimer's disease, paired helical filaments composed mainly of abnormally phosphorylated tau accumulate in certain selected neurons of the brain, and microtubules are rarely seen in the affected cells. In the present study, the binding of 32P-labeled 8-azidoguanosine triphosphate ([gamma-32P]8N3GTP), the photoaffinity analogue of GTP to the beta-subunit of tubulin in brain homogenates was found to be markedly lower in patients with Alzheimer's disease than in aged control human cases. No significant differences were observed in the levels of the alpha- and beta-subunits of tubulin between Alzheimer's disease and control brains obtained 2-7 h postmortem. In nine of 19 Alzheimer's disease and 11 of 12 control autopsied brains (2-7 h postmortem and stored at -75 degrees C) tubulin was isolated successfully from brain cytosol by in vitro polymerization induced with DEAE-dextran. The GTP binding was observed in the two cycled assembled microtubule preparations from all the normal control, and in eight of nine Alzheimer's disease cases. Alzheimer's disease microtubule preparations contained varying amounts of abnormally phosphorylated tau, whereas no abnormal tau was detected in the control brain preparations. Addition of bovine tau to bovine, normal human, and Alzheimer's disease brain tubulin preparations markedly increased GTP binding to the beta-subunit. An alkaline phosphatase-treated paired helical filament-enriched preparation increased by approximately twofold the GTP binding to bovine brain tubulin. GTP binding to tubulin prepared by phosphocellulose chromatography of two cycled microtubules from three Alzheimer's disease and three normal control brains, revealed insignificant differences between the two groups. These findings have suggested that (1) tau protein promotes the GTP binding to the beta-subunit of tubulin, and (2) the breakdown of the microtubule system in brains of patients with Alzheimer's disease might in part be due to the abnormal phosphorylation of tau which depresses the GTP binding.
An Operational Amplifier with Multipath Miller Zero Cancellation for RHP Zero Removal (1993)

The paper presents a Multipath Miller Zero Cancellation (MMZC) technique to remove the Right Half Plane Zero (RHPZ) in Miller compensated operational amplifiers. For comparison four different CMOS amplifiers have been integrated: a reference circuit without RHPZ removal, two circuits with traditional resistor and cascode removal techniques and finally the circuit with Multipath Miller Zero Cancellation Measurements confirm that MMZC increases the bandwidth of a microamp Miller compensated output stage from 3MHz to 3MHz, while maintaining the robustness necessary for class-AB operation. The traditional methods for RHPZ removal fail under the same conditions and give rise to peaking ('the output bump')
117 Outcomes of Operative and Nonoperative Treatment for Adult Spinal Deformity (2014)

INTRODUCTION: Adults with spinal deformity present with pain and disability. Our objective was to compare outcomes for op and nonop treatment for adult spinal deformity (ASD) based on a prospective, multicenter patient population. METHODS: Multicenter, prospective analysis of consecutive ASD patients. Inclusion criteria: age >18 year and ASD. Propensity scores were used to match operative (op) and nonoperative (nonop) patients based on baseline (BL) Oswestry Disability Index (ODI), SRS22, maximum thoracolumbar/lumbar Cobb angle, pelvic incidence to lumbar lordosis mismatch (PI-LL), and leg pain numeric rating scale (NRS) score. RESULTS: Six hundred eighty-nine patients met criteria, including 286 op and 403 nonop, with mean ages of 53 and 55 years, minimum 2-year follow-up rates of 86% and 55%, and mean follow-up of 24.7 and 24.8 months, respectively. At BL, compared with nonop, op patients had significantly worse HRQL based on ODI, SRS22, SF36, and leg and back pain NRS (P < .001) and had worse deformity based on pelvic tilt, PI-LL, and C7SVA (P < .002). Before reaching min 2-year follow-up, 38 nonop patients converted to op treatment and were analyzed in the op group. At min 2-year follow-up, all HRQL measures assessed significantly improved for op patients (P < .001), but none of these measures improved significantly for nonop patients (P > .11). 97 matched op-nonop pairs were identified based on propensity scores. At last follow-up, the 97 matched op patients had significant improvement in all HRQL measures assessed (P < .001), but the 97 matched nonop patients lacked significant improvement in any of the HRQL measures (P > .20). Paired op-nonop analysis demonstrated the op patients to have significantly better HRQL scores at follow-up for all measures assessed (P < .001), except SF36 MCS (P = .058). Operative overall minor and major complication rates were 53% and 40%, respectively. CONCLUSION: Op treatment for ASD can provide significant improvement of HRQL measures at min 2-year follow-up. In contrast, nonop treatment appears to at best maintain presenting levels of pain and disability.
Age dependent sensitivity of two-photon isomerization of rhodopsin chromophores in the human retina(Conference Presentation) (2016)

Light sensation relies on photoisomerization of chromophores in rod and cone photoreceptor cells. Spectral sensitivity of these photoreceptor cells in the retina is determined by the absorption spectra of their pigments which covers a range from 400 nm to above 700 nm. Regardless the mechanism leading to visual pigment isomerization, light sensation is triggered every time visual pigment molecules change their conformation. Thus, two-photon absorption (TPA) should produce the same result (visual sensation) as single photon absorption of light. This observation was positively verified and published by our group. During human psychophysics experiments, we found that humans can perceive light in the infrared (IR) range as colors that match half of the wavelength of the applied laser beam. Other experiments and theoretical research, such as mouse electrophysiology, biochemical studies of TPA in rhodopsin or molecular modeling studies, confirmed that visual sensation can be triggered by TPA. There are few publications describing human near infrared (NIR) perception and no formal proposals to use this phenomenon to improve ophthalmic diagnosis and monitor treatment. Here we report that the use of novel instrumentation revealed that the sensitivity threshold for NIR vision depends on age.
The versatile steroid nucleus: Design and synthesis of a peptidomimetic employing this novel scaffold. (1993)

The design and synthesis of peptidomimetic 1 employing the novel cyclopentanoperhydrophenanthrene skeleton is described. The large body of steroid literature allows for the introduction of diverse peptidal side chains with precise regio- and stereoselective control. Compound 1 binds to the fibrinogen receptor on blood platelets (GP IIb/IIIa), for which it was designed, with an IC50 of ca. 100 μM.
Protection by α2‐macroglobulin of tissue plasminogen activator against inhibition by plasminogen activator inhibitor‐1 (1997)

Tissue plasminogen activator (tPA) is widely used in the treatment of acute myocardial infarction (MI). However, its thrombolytic efficacy does not correlate with the dose administered. The interactions between tPA, alpha2-macroglobulin (alpha2-M), and plasminogen activator inhibitor-1 (PAI-1) were investigated both in vitro and in patients undergoing tPA therapy for MI in an attempt to identify variables that might affect the clinical efficacy of tPA. Purified alpha2-M (5.4 mg/ml) protected 16.0% or 22.4% of tPA (12.5 IU/ml) activity from inhibition by PAI-1 at 4 or 8 IU/ml in vitro. Of nine patients treated with 5-20 mega IU of tPA for MI, the plasma activity of tPA remained increased for 15-30 min after the cessation of infusion in eight; the patient who failed to exhibit a persistent increase in tPA activity had a low plasma concentration of alpha2-M. Total tPA activity, derived from the area under the activity-versus-time curve (AUC), showed a significant inverse correlation with the ratio of the plasma PAI-1 activity to the plasma alpha2-M concentration. Total tPA activity did not correlate with plasma PAI-1 activity or plasma alpha2-M concentration alone. Results suggest that alpha2-M, by binding to tPA, protects the latter against inhibition by PAI-1.
Supplementary Table 9 from Improving the Performance of Somatic Mutation Identification by Recovering Circulating Tumor DNA Mutations (2023)

&lt;p&gt;ctDNA mutations identified by cmDetect for the breast cancer metastatic cases.&lt;/p&gt;
Systemic therapies for metastatic hormone‐sensitive prostate cancer: network meta‐analysis (2021)

All three ARIs are effective therapies for mHSPC; apalutamide was the best tolerated. All three seemed more effective than docetaxel. These findings may facilitate individualised treatment strategies and inform future comparative trials.