gebhart/patrepeval huggingface dataset:
CD30+ Cutaneous Lymphoma in Association With Atopic Eczema (2004)

Although we have not been able to establish a causative link, we believe that the association of these 2 conditions has not occurred by chance. Biopsies of lesional skin from subjects with atopic eczema exhibit a proportion of CD30 cells, and clonal transformation of this subpopulation might account for the CD30(+) lymphomas in our patients.
From Bulk to Nanoparticles: An Overview of Antiviral Materials, Its Mechanisms, and Applications (Part. Part. Syst. Charact. 8/2021) (2021)

In article number 2100044, Lopes and co-workers discuss the progress in materials designed against viruses. Antiviral mechanisms, such as virucidal, virus binding, and drug delivery, are reviewed. The study evaluates several antiviral materials, from bulk to nanoparticles, and their applications targeting different viruses.
Allergenic Relevance of &lt;i&gt;Cupressus arizonica&lt;/i&gt; Pollen Extract and Biological Characterization of the Allergoid (2002)

The PPT C. arizonica pollen extract shows good in vitro diagnostic potential and its chemically modified form offers the features of a monomeric allergoid. It might therefore lend itself to the development of a product to be administered by the sublingual or oromucosal route for immunotherapy of individuals with cypress pollinosis.
Test-Time Adaptation for Visual Document Understanding (2022)

For visual document understanding (VDU), self-supervised pretraining has been shown to successfully generate transferable representations, yet, effective adaptation of such representations to distribution shifts at test-time remains to be an unexplored area. We propose DocTTA, a novel test-time adaptation method for documents, that does source-free domain adaptation using unlabeled target document data. DocTTA leverages cross-modality self-supervised learning via masked visual language modeling, as well as pseudo labeling to adapt models learned on a \textit{source} domain to an unlabeled \textit{target} domain at test time. We introduce new benchmarks using existing public datasets for various VDU tasks, including entity recognition, key-value extraction, and document visual question answering. DocTTA shows significant improvements on these compared to the source model performance, up to 1.89\% in (F1 score), 3.43\% (F1 score), and 17.68\% (ANLS score), respectively. Our benchmark datasets are available at \url{https://saynaebrahimi.github.io/DocTTA.html}.
One year of cyclic unrest in a hydrothermal field as a harbinger of a volcanic eruption (2021)

Abstract One year of deformation and seismicity prior to a volcanic eruption in March 2021 at an oblique plate boundary in Iceland created a unique opportunity to study the interaction between upwelling magma and geothermal processes. We apply poroelastic modelling to explain satellite geodetic data showing three uplift and subsidence cycles at the Svartsengi geothermal field and use gravity data to constrain the density of intruded material. We use recordings on optical cable to generate a high-resolution earthquake catalogue and developed new waveform stacking and migration methods to detect and locate 39,500 earthquakes. The resulting model explains the geodetic, gravity, and seismic data by magmatic derived gas intruded into a horizontal sealed aquifer at 4 km depth in the roots of the geothermal field at the top of up-doming brittle-ductile boundary. The total injected volume is estimated 9.5·107m3 with optimal density of 840 kg/m3. Our results suggest upward migration of three packages of volcanic gas along the brittle-ductile boundary from a subcrustal magmatic source 8–10 km east of the geothermal field, with important implications for the dynamics leading to the eruption.
: Demonstration of Acoustic Sensing Techniques for Fuel-Distribution System Condition Monitoring : Final Report on Project F07-AR07 (2021)

Leaks in fuel storage tanks and distribution piping systems have been identified as a mission-critical problem by the Department of Defense and the U.S. Army. Fuel system leaks are often hard to locate and virtually inaccessible for efficient repair because the piping is often installed under a concrete pad or tarmac. Leak repair could cost up to $2,000, and the cost of cleanup and re-mediation for fuel spills can exceed $50,000. In this project an acoustic remote sensing system was installed to monitor an Army heliport refueling system to determine whether it could detect and accurately locate fuel leaks using computer software technolo-gies to distinguish acoustic leakage signatures from normal fuel system operational noise. Demonstration and validation efforts were disadvantaged by the fact that no fuel leaks occurred in the monitored system for the duration of the project. However, the monitoring system did identify several unusual acoustic events within the fueling system and interpret them as indications of intermittent malfunctions of a check valve and a fuel pump. The 30-year ROI is about 6.42. Further work is required before the technology can be fully implemented: its ability to detect fluid leaks must be proven, and the system specifications must be certified through an EPA third party.
Overexpression of the Key Enzymes in the Methylerythritol 4-phosphate Pathway in <i>Corynebacterium glutamicum</i> for Improving Farnesyl Diphosphate-Derived Terpene Production (2020)

A systematic and combinatorial optimization has been employed to metabolically engineer microbes for identifying key gene targets for overexpression to increase the intermediate pools for terpenoid production. Herein, the methylerythritol 4-phosphate (MEP) pathway in <i>Corynebacterium glutamicum</i>, an industrial host, was investigated to identify the key genes whose overexpression would improve the production of farnesyl diphosphate (FPP)-derived terpenoids (squalene and α-farnesene). Using a combinatorial approach with the single, double, and triple expression of genes in the MEP pathway in a high-throughput fermentation, overexpression of the <i>ispDF</i> genes, along with the known <i>dxs</i> and <i>idi</i> genes, was most effective at increasing the squalene contents, i.e., by 14-fold. The <i>dxr</i> gene was identified as the key target enzyme for α-farnesene production. This result could provide fundamental information for improving the metabolic engineering of <i>C. glutamicum</i> for terpene production via an optimized MEP pathway.
Measuring aspheres quickly: tilted wave interferometry (2017)

Functional surfaces with a rising degree of complexity are becoming increasingly important for modern industrial products. It is common knowledge that one cannot produce surfaces better than it is possible to measure them. Consequently, the demand for their effective and precise measurement has increased to the same extent as their production capabilities have grown. Important classes of optical functional surfaces are aspheres and freeforms. Both types of surfaces have become essential parts of modern optical systems such as laser focusing heads, sensors, telescopes, glasses, head-mounted displays, cameras, lithography steppers, and pickup heads. For all of them, the systematic quality control in the process of their fabrication is essential. We review the challenges of asphere and freeform testing and how available metrology systems cope with it. A special focus is on tilted wave interferometry and how it compares to other methods.
Smart Nanocarrier Based on PEGylated Hyaluronic Acid for Cancer Therapy (2011)

Tumor targetability and site-specific drug release of therapeutic nanoparticles are key factors for effective cancer therapy. In this study, poly(ethylene glycol) (PEG)-conjugated hyaluronic acid nanoparticles (P-HA-NPs) were investigated as carriers for anticancer drugs including doxorubicin and camptothecin (CPT). P-HA-NPs were internalized into cancer cells (SCC7 and MDA-MB-231) via receptor-mediated endocytosis, but were rarely taken up by normal fibroblasts (NIH-3T3). During in vitro drug release tests, P-HA-NPs rapidly released drugs when incubated with cancer cells, extracts of tumor tissues, or the enzyme Hyal-1, which is abundant in the intracellular compartments of cancer cells. CPT-loaded P-HA-NPs (CPT-P-HA-NPs) showed dose-dependent cytotoxicity to cancer cells (MDA-MB-231, SCC7, and HCT 116) and significantly lower cytotoxicity against normal fibroblasts (NIH-3T3) than free CPT. Unexpectedly, high concentrations of CPT-P-HA-NPs demonstrated greater cytotoxicity to cancer cells than free CPT. An in vivo biodistribution study indicated that P-HA-NPs selectively accumulated into tumor sites after systemic administration into tumor-bearing mice, primarily due to prolonged circulation in the blood and binding to a receptor (CD44) that was overexpressed on the cancer cells. In addition, when CPT-P-HA-NPs were systemically administrated into tumor-bearing mice, we saw no significant increases in tumor size for at least 35 days, implying high antitumor activity. Overall, P-HA-NPs showed promising potential as a drug carrier for cancer therapy.
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes (2017)

Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 weeks after treatment. Our results revealed differential expression of miR-146a-5p, miR-146b-5p, miR-425-3p and miR-24-3p according to treatment response. These results were replicated in two independent clinical trials of MDD, a well-characterized animal model of depression, and post-mortem human brains. Furthermore, using a combination of bioinformatics, mRNA studies and functional in vitro experiments, we showed significant dysregulation of genes involved in MAPK/Wnt signalling pathways. Together, our results indicate that these miRNAs are consistent markers of treatment response and regulators of the MAPK/Wnt systems.
Consistent Resource Utilization for Cross-Platform and Replicable Load-Testing: a Position Paper (2021)

This position paper discusses assuring the comparability of benchmarking results across hardware platforms by introducing resource utilization as a universal equivalent. By sustaining resource utilization at a constant level while conducting a benchmark, comparing results becomes fair. This idea is prototyped in Procrustes, a library aiming to assure the desired level of resource utilization by autonomically adjusting the configuration of a benchmark at runtime. Procrustes implements PID- and LQR-based feedback control to ensure the target resource utilization. We showcase Procrustes to regulate the GUI GC benchmark deployed on a bare metal platform and a VM.
Inhibitors of Raf Kinase Activity Block Growth of Thyroid Cancer Cells with <i>RET/PTC</i> or <i>BRAF</i> Mutations <i>In vitro</i> and <i>In vivo</i> (2006)

Compounds that inhibit kinase activity are effective growth inhibitors for poorly differentiated thyroid cancer cell lines with either RET or RAF mutations, and hold promise for treatment of most forms of papillary thyroid carcinoma.
Association of Ultra-Short-Term Intraocular Pressure Fluctuation With Disease Progression in Primary Angle Closure Glaucoma: The CUPAL Study (2022)

Between RNFL 'progressive' and 'stable' PACG eyes, significant differences in ultra-short-term IOP fluctuation at the 1-hour period after falling asleep were identified. The first hour of sleeping may be the most sensitive period for detecting significant ultra-short-term IOP fluctuation in PACG eyes.
Determination of Accuracy and Precision of Lesion Uptake Measurements in Human Subjects with Time-of-Flight PET (2014)

TOF reconstruction leads to more accurate and precise measurements, both within a subject and across subjects, of the activity in small lesions under clinical conditions.
Compatibility of topical agents with tumor treating fields (TTFields) for treatment of associated skin events in glioblastoma (GBM). (2020)

e24126 Background: TTFields are low intensity, intermediate frequency, alternating electric fields applied continuously using 2 pairs of skin-affixed transducer arrays. TTFields are FDA-approved in GBM and mesothelioma. The most common TTFields-related adverse event (AE) is mild-to-moderate dermatitis (beneath arrays), via long-term irritant exposure and local hyperhidrosis and occlusion exacerbation. Skin reaction mitigation strategies may improve quality-of-life (QoL) and ensure usage, as maximal survival benefits have been correlated with duration of use. Not all skin care products are TTFields compatible and may increase electrical impedance and lead to beneath array temperature increases. The aim of this in vivo study was to investigate the effects of 62 commercially available skin care products on electrical impedance during TTFields treatment. Methods: TTFields (200 kHz; optimal GBM frequency) were applied to rats using transducer arrays made of the same ceramic disks and hydrogels used in patients with GBM. To test electrical impedance effects, skin care products were applied to the skin immediately before array placement. The change in impedance relative to naïve skin was measured using the Optune device. Sixty-two commercially available products from 8 groups (adhesive removers, antibiotics, antiperspirants, antiseptics, cleansers, moisturizers, skin barriers, and topical corticosteroids) were evaluated. Results: Most lotions, soaps, foams, and solutions had minimal effect on electrical impedance, while petrolatum-based ointments significantly increased electrical impedance. Conclusions: TTFields compatible skin care products that did not affect electrical impedance were identified from each of the 8 groups and could be considered for further evaluation. All petrolatum-based ointments that were tested led to an increase in electrical impedance and are thus not recommended. Local application of TTFields compatible skin care products should be prospectively investigated in the clinical setting for their potential role in minimizing TTFields–related skin AEs. The randomized, double-blind PROTECT (PROphylactic skin Toxicity thErapy with Clindamycin and triamcinolone in GBM patients Treated with TTFields) study, should help establish which products best reduce skin AEs in patients with GBM and assess impact on QoL.
Electrocortical Pathology in a Rat Model of Penetrating Ballistic-Like Brain Injury (2010)

Traumatic brain injury (TBI) causes severe disruption of cerebral electrical activity and electroencephalography (EEG) is emerging as a standard tool to monitor TBI patients in the acute period of risk for secondary injuries. However, animal studies of EEG pathology in the context of TBI are surprisingly sparse, largely because of the lack of real-time continuous EEG (cEEG) monitoring in animal TBI models. Here, we performed long-term EEG monitoring to study nonconvulsive seizures (NCS), periodic epileptiform discharges (PED), and EEG power spectra following three injury severity levels in a rat model of penetrating ballistic-like brain injury (PBBI). EEG signals were recorded continuously from bilateral hemispheres of freely behaving rats for 72 h and for 2 h on days 7 and 14 after the injury. We report that the incidence of NCS and PED positively correlated with the injury severity, where 13%, 39%, and 59% of the animals exhibited NCS, and 0%, 30%, and 65% of the animals exhibited PED following 5%, 10% and 12.5% PBBI, respectively. Similar correlations existed for the number of NCS and PED events and their duration. NCS and PED occurred either independently or in tandem. Longer NCS durations were associated with larger lesion volumes. Significant EEG slowing evidenced by the EEG power shift toward the δ frequency band (0.5-4 Hz) occurred within 2 h after PBBI, which resolved over time but persisted longer after greater injury severity. In contrast, decreases in higher frequency power (i.e., 30-35 Hz) remained depressed throughout 14 days. This is the first long-term cEEG study of the acute injury phase in a rat model of severe TBI, demonstrating common occurrences of clinically observed electrocortical pathology, such as NCS, PED, and cortical slowing. These EEG pathologies may serve as critical care biomarkers of brain injury, and offer clinically relevant metrics for studying acute therapeutic interventions.
A Vehicle-Independent Autonomous Lane Keeping and Path Tracking System (2021)

This paper describes a lateral controller for path following developed to work on a wide range of vehicles without any changes in tuning between platforms. This vehicle independent path following controller employs a cascaded adaptive architecture, with the outer loop controlling the path dynamics and the inner loop controlling the vehicle dynamics. The controller is validated on four vehicle models in simulation at a variety of speeds. The controller is then implemented and validated in real-time on a Lincoln MKZ, a Class-8 Peterbilt 579 cab, a Peterbilt 579 with a loaded trailer, and a 1/10th scale RC car. The controller is shown to perform well on the four simulated vehicles and the four experimental platforms at a range of longitudinal speeds, matching or exceeding human performance with consistent and smooth steering.
Multi-Information Source Fusion and Optimization to Realize ICME: Application to Dual Phase Materials (2018)

Integrated Computational Materials Engineering (ICME) calls for the integration of computational tools into the materials and parts development cycle, while the Materials Genome Initiative (MGI) calls for the acceleration of the materials development cycle through the combination of experiments, simulation, and data. As they stand, both ICME and MGI do not prescribe how to achieve the necessary tool integration or how to efficiently exploit the computational tools, in combination with experiments, to accelerate the development of new materials and materials systems. This paper addresses the first issue by putting forward a framework for the fusion of information that exploits correlations among sources/models and between the sources and `ground truth'. The second issue is addressed through a multi-information source optimization framework that identifies, given current knowledge, the next best information source to query and where in the input space to query it via a novel value-gradient policy. The querying decision takes into account the ability to learn correlations between information sources, the resource cost of querying an information source, and what a query is expected to provide in terms of improvement over the current state. The framework is demonstrated on the optimization of a dual-phase steel to maximize its strength-normalized strain hardening rate. The ground truth is represented by a microstructure-based finite element model while three low fidelity information sources---i.e. reduced order models---based on different homogenization assumptions---isostrain, isostress and isowork---are used to efficiently and optimally query the materials design space.
Winterization of Cold Climate and Arctic Offshore Operations (2014)

For oil and gas exploration and production projects in cold climate and Arctic environments, much attention has been paid to winterization of the facilities. Conferences with the theme “Vessel Winterization” are held regularly and standards like ISO 19906, Arctic Offshore Structures, are concerned with winterization of facilities. We will, however, highlight the need to winterize all aspects of the operation: - It is not sufficient that the vessel is winterized if the staff does not have competence to work in cold climate - It is not sufficient to ensure a good working environment if the staff is not prepared to work at the remote location - It is not sufficient to winterize the facilities if the personnel cannot be rescued in case of emergency - It is not sufficient to ensure safe operations if the oil spill equipment does not work at all in case of an oil spill during the cold period We could continue to list important aspects of oil and gas exploration and production projects in cold climate or Arctic environment that are not adequately robust even if the “facilities are winterized” and we will highlight the need to include all aspects of the operation planning in the preparation for winterization. Of particular importance is the involvement of the personnel when it comes to preparedness, health, and protection to ensure that the staff is adequately taken care of when working in cold climate and Arctic areas. The presentation will, therefore, also deal with practical aspects of health in cold climates, including pre-assignment health requirements, as well as competence and training with respect to “Winterization of Operations”. The paper, thus, includes recommendations for health requirements, training and preparedness in order to prevent negative health impacts on the individual and on the operation.
Phase change nanodots patterning using a self-assembled polymer lithography and crystallization analysis (2008)

Crystallization behavior of scalable phase change materials can be studied on nanoscale structures. In this paper, high density ordered phase change nanodot arrays were fabricated using the lift-off technique on a self-assembled diblock copolymer template, polystyrene-poly(methyl-methacrylate). The size of the nanodots was less than 15 nm in diameter with 40 nm spacing. This method is quite flexible regarding the patterned materials and can be used on different substrates. The crystallization behavior of small scale phase change nanodot arrays was studied using time-resolved x-ray diffraction, which showed the phase transition for different materials such as Ge15Sb85, Ge2Sb2Te5, and Ag and In doped Sb2Te. The transition temperatures of these nanodot samples were also compared with their corresponding blanket thin films, and it was found that the nanodots had higher crystallization temperatures and crystallized over a broader temperature range.