gebhart/patrepeval huggingface dataset:
Neural networks for behavioral conditioning of mobile robots (1991)

Biological systems provide excellent examples of self-organization in the form of visual object learning and behavioral adaptation. In light of this, a control system for mobile robots which is reminiscent of the modular distributed architecture of the brain is developed. The system utilizes neural networks for learning and performance at all stages, from visual object recognition to behavioral conditioning. The system includes networks for early visual perception, pattern learning and object recognition, object associations, emotional states, behavioral actions, motor control, and behavioral conditioning. These networks are interconnected by a variety of hard-wired as well as adaptive pathways. The system demonstrates self-organizing, teacher controlled, and reinforcement learning paradigms, and integrates these into a system in which external events interact with internal emotional states to produce emergent behaviors.
The system, which has been implemented on a mobile robot MAVIN (Mobile Adaptive VIsual Navigator), takes as visual input various patterns of light (i.e., objects), learns and recognizes these objects invariant to size, location, orientation, angle of gaze (foreshortening effects), and aspect on the visual field. The system associates reflex motor behaviors with certain learned visual objects. A robot eye motion system that can detect and actively track moving objects is used on MAVIN. The system adapts to smooth motions of targets and executes predictive (compensatory) saccades, or suddenly saccades to a new target appearing in the visual field. This system also includes a vestibular-ocular reflex in which the neck moves to compensate for excessive eye motions. Using visual error feedback, MAVIN learns to compensate for motor errors associated with body movements. Control of these adaptive motor behaviors is achieved using collections of Adaptive Linear Neurons - ADALINEs.
These sensory-motor reflex associations are finally used to demonstrate classical conditioning, in which a new visual stimulus is associated with the behavior triggered by either the on-set (conditioned excitor) or off-set (conditioned inhibitor) of some other stimulus. This type of associative learning is achieved using a REcurrent Associative Dipole - READ Circuit. Extinction of a conditioned excitor, and the non-extinction of a conditioned inhibitor are also demonstrated. These various conditioning paradigms are well known in animal behavior studies.
Implementation of Combined Loading to Calculate Ground Bearing Pressure under Crawler Crane Tracks (2021)

Modular projects in the construction industry employ high-capacity crawler cranes. Due to the significant increase in the weights of modules in recent years, ensuring the integrity of ground support under the crane tracks is paramount for avoiding collapse, which ultimately results in dire consequences for the workers and the project. Consequently, the first order of business is to determine the expected pressure under the tracks to determine the ground support necessary. Typically, the ground bearing pressure (GBP) is computed using the fundamentals of statistics at the four edges of the crane (left front and rear and right front and rear), assuming the track width is under uniform loading. However, finite-element analysis (FEA) shows that the GBP values vary even for two corners of an edge (widthwise). In contrast to the traditional four-point approach, the present study proposes a new methodology to not only calculate the GBP at all the eight corners of crawler tracks, but also to calculate the GBP anywhere on the track area, which can establish the GBP profile in detail.
Recent Advances in the Design of Ionenes: Toward Convergence with High‐Performance Polymers (2019)

Abstract Ionenes, condensation polymers wherein the charge (typically cationic) lies directly within the polymer backbone, have been known for over 85 years. Historically, ionenes have been synthesized from 3 o diamines and α,ω‐dihaloalkanes, forming chains of ammonium cations tethered by flexible hydrocarbon linkages with “free” halide anions. However, the requisite building blocks of ionenes are by no means limited only to such molecules. In recent years, ionenes with more sophisticated backbone chemistries have been produced, with a trend toward the use of functionalities associated with classical “high‐performance” condensation polymers such as polyimides and polyarylamides. The expansion of ionenes is also catalyzed by the rapid growth of research in imidazolium‐based ionic liquids (ILs), wherein the combination of ionenes with ILs can yield unexpected behaviors. Furthermore, when considering the largely unexplored experimental space in anionic ionenes, the opportunities for new materials are virtually endless. This review primarily focuses on developments in ionenes published in the scientific literature since 2010, but also includes some older examples that may not have received sufficient attention at the time of their original publication yet can provide some key lessons for the future of ionene design.
Ibrutinib restores immune cell numbers and function in first-line and relapsed/refractory chronic lymphocytic leukemia (2020)

Ibrutinib positively modulates many T-cell subsets in chronic lymphocytic leukemia (CLL). To understand ibrutinib's effects on the broader landscape of immune cell populations, we comprehensively characterized changes in circulating counts of 21 immune blood cell subsets throughout the first year of treatment in patients with relapsed/refractory (R/R) CLL (n = 55, RESONATE) and previously untreated CLL (n = 50, RESONATE-2) compared with untreated age-matched healthy donors (n = 20). Ibrutinib normalized abnormal immune cell counts to levels similar to those of age-matched healthy donors. Ibrutinib significantly decreased pathologically high circulating B cells, regulatory T cells, effector/memory CD4<sup>+</sup> and CD8<sup>+</sup> T cells (including exhausted and chronically activated T cells), natural killer (NK) T cells, and myeloid-derived suppressor cells; preserved naive T cells and NK cells; and increased circulating classical monocytes. T-cell function was assessed in response to T-cell receptor stimulation in patients with R/R CLL (n = 21) compared with age-matched healthy donors (n = 18). Ibrutinib significantly restored T-cell proliferative ability, degranulation, and cytokine secretion. Over the same period, ofatumumab or chlorambucil did not confer the same spectrum of normalization as ibrutinib in multiple immune subsets. These results establish that ibrutinib has a significant and likely positive impact on circulating malignant and nonmalignant immune cells and restores healthy T-cell function.
Lactosylated liposomes for targeted delivery of doxorubicin to hepatocellular carcinoma (2012)

These data suggest that lactosylated liposomes are promising drug delivery vehicles for hepatocellular carcinoma.
Commentary: Object-Oriented Programming of Complex fault-Tolerant Real-Time Systems (1996)

For the real-time computing, an operating system is one of the most important component, to realize the required computing functions with time critical conditions. In this paper, OS Route MIX is proposed for evaluating OS performance. By applying this performance measure, the practical OS designs are shown. To improve OS performance, Three layers structure model is defined, to add an OS process as one of OS function implementation, that is a way of simplifying OS design and making performance improved. The practical results and data are shown.
Abstract 3226: The IRF8-osteopontin-CD44 axis functions as an immune checkpoint to control CD8+ T cell activation and tumor immune evasion (2019)

Despite breakthroughs in immune checkpoint inhibitor (ICI) immunotherapy, not all human cancers respond to ICI immunotherapy and only fraction of patients with responsive tumors have a durable response to current ICI immunotherapy. This clinical conundrum suggests that additional immune checkpoints may exist, particularly in cancers resistant to current ICI immunotherapy, such as colorectal cancer. We report here that interferon regulatory factor 8 (IRF8) deficiency led to impairment of cytotoxic T lymphocyte (CTL) activation in a peptide vaccine model and allowed allograft transplant tumor tolerance. These effects were associated with upregulation of the CTL surface marker CD44. However, analysis of chimeric mice with competitive reconstitution of wild type and IRF8 KO bone marrow cells as well as mice with IRF8 deficiency only in T cells indicated that IRF8 plays no intrinsic role in CTL activation. Instead, IRF8 functioned as a repressor of osteopontin (OPN), the physiological ligand for CD44 on T cells, in CD11b+Ly6CloLy6G+ myeloid cells and OPN acted as a potent T cell suppressor. In vitro stimulation of CTLs in the presence of OPN resulted in decreased expression of activation markers CD69 and CD25 and inhibited proliferation and interferon gamma (IFNg) secretion. Expression of OPN was found to be upregulated in both myeloid cells and colon epithelial cells following silencing of IRF8 expression. IRF8 bound to the Spp1 promoter, which encodes OPN, to repress OPN expression in colon epithelial cells. Correspondingly, human colon carcinoma cells exhibited decreased IRF8 and increased OPN expression. These increased OPN levels inhibited human PBMC proliferation and IFNg secretion. The elevated expression of OPN in human colon carcinoma was correlated with decreased patient survival. Our data indicates that myeloid and tumor cell-expressed OPN acts as a novel immune checkpoint to suppress T cell activation and confer host tumor immune tolerance. Blockade of this checkpoint may expand the pool of patients who may benefit from ICI immunotherapy.Citation Format: John D. Klement, Amy V. Paschall, Priscilla S. Redd, Mohammed L. Ibrahim, Chunwan Lu, Dafeng Yang, Esteban Celis, Scott I. Abrams, Keiko Ozato, Kebin Liu. The IRF8-osteopontin-CD44 axis functions as an immune checkpoint to control CD8+ T cell activation and tumor immune evasion [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 3226.
Dataset Cleaning — A Cross Validation Methodology for Large Facial Datasets using Face Recognition (2020)

In recent years, large “in the wild” face datasets have been released in an attempt to facilitate progress in tasks such as face detection, face recognition, and other tasks. Most of these datasets are acquired from webpages with automatic procedures. As a consequence, noisy data are often found. Furthermore, in these large face datasets, the annotation of identities is important as they are used for training face recognition algorithms. But due to the automatic way of gathering these datasets and due to their large size, many identities folder contain mislabeled samples which deteriorates the quality of the datasets. In this work, it is presented a semi-automatic method for cleaning the noisy large face datasets with the use of face recognition. This methodology is applied to clean the CelebA dataset and show its effectiveness. Furthermore, the list with the mislabelled samples in the CelebA dataset is made available.
Frequency stabilization of a semiconductor laser using the spectrum of a Fabry-Perot etalon controlled by the Rb absorption line (2005)

We report on the stabilization of a semiconductor laser’s frequency, using spectra-controlled etalon. As the spectra of an etalon are controlled by one of the Rb absorption lines, they provide highly stable reference frequencies in a broad frequency range. When we adapted the PEAK method to the etalon’s spectra and used a Doppler-free absorption line of Rb atoms as the control signal for the newest model of our system, relative optical frequency stability of 2.91x10<sup>-11</sup>&le;&sigma;(2,&tau;)&le;3.72x10<sup>-10</sup> was achieved in averaging time for 0.04s&le;&tau;&le;100s.
Reconstrucción de una mandíbula posterior atrofiada con técnica de interposición (inlay) de bloque óseo bovino inorgánico (2010)

En el presente articulo se presenta el caso de una mujer de 53 anos con grave atrofia mandibular que posteriormente fue somentida a una reconstruccion bilateral con injerto interpuesto (inlay) de bloque oseo bovino inorganico. Cuatro meses despues, se tomo una muestra osea para la evaluacion histologica y se colocaron ocho implantes dentales. Estos implantes se cargaron con una protesis provisional durante otros cuatro meses. Cuando se coloco la protesis definitiva, 8 meses despues de la intervencion, todos los implantes estaban osteointegrados. El analisis histologico mostro que el hueso injertado rodeado por hueso neoformado. Los resultados indican que los bloques de hueso bovino inorganico son utiles como alternativa al injerto autogeno para el aumento mandibular posterior utilizando la tecnica de injerto interpuesto (inlay).
An open software for bitstream-based quality prediction in adaptive video streaming (2020)

HTTP Adaptive Streaming (HAS) has become a popular solution for multimedia delivery nowadays. However, because of throughput fluctuations, video quality may be dramatically varying. Also, stalling events may occur during a streaming session, causing negative impacts on user experience. Therefore, a main challenge in HAS is how to evaluate the overall quality of a session taking into account the impacts of quality variations and stalling events. In this paper, we present an open software, called BiQPS, using a Long-Short Term Memory (LSTM) network to predict the overall quality of HAS sessions. The prediction is based on bitstream-level parameters, so it can be directly applied in practice. Through experiment results, it is found that BiQPS outperforms four existing models. Our software has been made available to the public at https://github.com/TranHuyen1191/BiQPS.
Paleomagnetism of the Mesozoic Coast Range Ophiolite, California (1992)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Ameliorative Effect of Caryopteris grata benth.Against Arsenic-Induced Enzymatic Alterationsin Testis of Albino Balb/c Mice (2018)

Arsenic (As) contaminates drinking water worldwide and its potential impact on human health has been studied for decades. A number of traditional medicinal plants are used to counteract arsenic's deleterious effects on humans. Phytochemical screening of Caryopteris grata revealed the presence of Quercetin, myricetin, sesquiterpenoids, and spathulenol. The present study was designed to evaluate whether the crude extract of leaves of C. grata inhibited arsenic-induced testicular toxicity in albino BALB/c mice. To examine the effects, mice were divided into five groups (A-E) of 6 mice each: Group A was provided with distilled water and served as a control. Group B mice were given sodium arsenite (NaAsO 2 ) at a dose of 10 mg/kg body weight (bw) for 10 days orally. Groups C, D, and E were treated with NaAsO 2 plus graded doses of C. grata extract (150, 300, 400 mg/kg bw), respectively. Testicular activities of antioxidant enzymes such as CAT, POD, SOD, GSH, GSR, and serum testosterone levels were significantly (P<0.05) decreased in Group B compared to Group A. C. grata markedly normalized (P<0.05) levels of CAT (0.72 and 0.46 U/mint), POD (0.311 and 0.126 U/mint), SOD (2.11 and 1.33 U/mg protein), GSH (0.679 and 0.284 mol/g), and GSR (216.11 and 172.25 nmol/min/mg protein), along with testosterone levels (1.180.017 and 0.380.021 ng/ml) at the tested doses, respectively. Conclusively, the crude extract of C. grata leaves may inhibit both arsenic's adverse effect on male reproductive hormones and testicular oxidative damage in mice.
DWM-PUF: A low-overhead, memory-based security primitive (2014)

Physically Unclonable Function (PUF) is a security primitive to address hardware security issues such as chip authentication, Intellectual Property (IP) protection etc. Conventional CMOS PUFs are built on delay (inverter chains, scan chains etc.) or memory structures (like SRAM). In this paper, we propose a novel PUF which works on the principles of spintronic Domain Wall Memory (DWM). Conventional DWM is limited by pinning due to process variations induced surface roughness of the nanowire. We exploit this limitation towards chip-authentication. We propose two flavors of PUFs namely relay-PUF and memory-PUF. The proposed PUFs show excellent entropy (measured by Hamming Distance). We also analyze metrics such as robustness, area and power of the DWM-PUFs. The memory-PUF indicated up to an order of magnitude reduction in power compared to SRAM PUF.
Inflammatory biomarkers predicting prognosis in patients with acute dyspnea (2015)

Interleukin-8 and GDF-15 are strongly and independently related to risk of 90-day mortality in unselected patients admitted to the ED because of acute dyspnea, suggesting that they may guide first-line physicians at the ED in risk assessment which in turn could lead to more accurate level of care and treatment intensity.
Experimental assessment of the structure-borne noise in an aircraft cabin due to vibrating equipment (2015)

The structure-borne noise due to vibrating equipment (e.g., hydraulic pump, transformer rectifier unit, power transfer unit, avionic fan, etc.) could be a significant noise source inside commercial and business aircraft cabins. Thus, it is important to specify proper noise requirements for equipment suppliers. However, this is not as straightforward as it seems since the structure-borne noise generated by the equipment is not only dependent on the vibrating equipment but also on the dynamical behavior of the aircraft structure to which it is attached. This work investigates the potential of a well-known experimental procedure for predicting the noise generated in the cabin using characteristic properties of the vibration source and the receiving structure. The source is characterized by its structural mobility and free velocity. The receiving structure is characterized by its structural mobility and the transfer function between the applied force at the connection points and the acoustic pressure generated inside the cabin. The proposed method is validated from a small scale laboratory setup comprising of an avionic fan mounted onto an aluminum structure which is then coupled with a small reverberant chamber.
Changes in Serum Concentrations of Insulin-like Growth Factor-1 (IGF-1) during Different Methods of General Anesthesia (2003)

Background: IGFs (insulin-like growth factors) exert acute anabolic effects on protein and carbohydrate metabolism, and have a long-term impact on cell proliferation, differentiation, and apoptosis. The purpose of this study was to evaluate whether serum levels of IGF-1 were affected by the general anesthetics. Methods: Twenty patients, scheduled for a total abdominal hysterectomy were given either propofol (n = 10) or isoflurane (n = 10) general anesthesia. All patients were treated in a standardized manner in regard to surgical technique. Blood samples were taken before induction and at the time of peritoneal closure, postoperative 1 hour, and on postoperative days 2 and 5. Serum concentrations of IGF-1 were determined using an immunoradiometric assay. Results: IGF-1 levels decreased from the value before induction by 17.1% during surgery and 37.5% by day 5 in the propofol group. IGF-1 levels fell by 18.7% during surgery and returned to the preinduction level on day 5 after surgery in the isoflurane group. There were no differences in IGF-1 levels between the two groups with different methods of anesthesia. Conclusions: Our study suggests that general anesthesia with isoflurane is associated with a less effect in serum IGF-1 level than propofol. However, further experimental and clinical studies are needed to establish the definitive effect of general anesthetics on IGF.
Supramolecular Metal-Polypyridyl and Ru(II) Porphyrin Complexes: Photophysical, Electron Paramagnetic Resonance, and Electrochemical Studies (2008)

A series of mixed-metal supramolecular porphyrin arrays in which the geometry of the central metal-polypyridyl moiety defines the spatial arrangement of two or more Ru(II)-porphyrin units through axial coordination have been prepared by employing self-assembly based protocols, and their photophysical and electrochemical properties have been studied. The electrochemical properties of the constituent parts of these arrays depend only on their own chemical environment, regardless of the nuclearity and the overall charge of the compound; in this way species with predetermined redox patterns can be obtained via the synthetic control of the self-assembly process. Interestingly, several of these arrays are luminescent both at room and at low temperatures, and in many cases core-to-periphery or periphery-to-core intramolecular energy transfer processes take place according to the nature of the central metal template.
Hydrothermal preparation of Phyllostachys pubescens – nanocellulose/graphene aerogel as a simple device for supercapacitors (2019)

Bamboo nanocellulose can be regarded as a promising biomass material for the preparation of sustainable energy devices due to its unique structure, excellent properties, and wide range of sources. A highly conductive electrochemical energy storage was synthesized due to the excellent electrical conductivity of graphene and the high surface area of nanocellulose and graphene, which was beneficial for producing a network structure. The symmetric capacitor assembled from the Phyllostachys pubescens nanocellulose/graphene aerogel (CGA) electrode exhibited a high specific capacitance of 125.5 F/g at 5 mV/s and extreme stability of 98.3% capacitance retention ratio after 5000 cycles at 2 A/g. This nanocellulose-graphene electrode showed potential for future high-performance supercapacitors.
Bortezomib-induced enzyme-targeted radiotherapy (BETR) for AIDS-related malignancies: efficacy assessment by Monte Carlo and dosimetry modeling (2009)

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Parkinson’s VPS35[D620N] mutation induces LRRK2 mediated lysosomal association of RILPL1 and TMEM55B (2023)

Abstract The Parkinson’s VPS35[D620N] mutation causes lysosome dysfunction enhancing LRRK2 kinase activity. We find the VPS35[D620N] mutation alters expression of ∼350 lysosomal proteins and stimulates LRRK2 phosphorylation of Rab proteins at the lysosome. This recruits the phosphoRab effector protein RILPL1 to the lysosome where it binds to the lysosomal integral membrane protein TMEM55B. We identify highly conserved regions of RILPL1 and TMEM55B that interact and design mutations that block binding. In mouse fibroblasts, brain, and lung, we demonstrate that the VPS35 [D620N] mutation reduces RILPL1 levels, in a manner reversed by LRRK2 inhibition. Knock-out of RILPL1 enhances phosphorylation of Rab substrates and knock-out of TMEM55B increases RILPL1 levels. The lysosomotropic agent LLOMe, also induced LRRK2 kinase mediated association of RILPL1 to the lysosome, but to a lower extent than the D620N mutation. Our study uncovers a pathway through which dysfunctional lysosomes resulting from the VPS35[D620N] mutation recruit and activate LRRK2 on the lysosomal surface, driving assembly of the RILPL1-TMEM55B complex.