gebhart/patrepeval huggingface dataset:
Photochemical Generation of a Primary Vinyl Cation from (<i>E</i>)-Bromostyrene:  Mechanisms of Formation and Reaction (2003)

The photochemistry of (E)-bromostyrene was investigated to determine the nature of the product-forming intermediates and to clarify the mechanism of formation of vinylic cations and vinylic radicals. Both a cation- and a radical-derived product are formed, and the ionic origin of the former product is demonstrated by significant scrambling of the label, starting from specifically deuterated (E)-bromostyrene. MO calculations show that the isolated incipient primary vinyl cation is not a metastable species, but that specific interaction with a counterion in combination with a polar environment makes it metastable. The effects of variation of the wavelength of irradiation, solvent polarity, temperature, and isotopic substitution all agree with a mechanism of direct heterolytic C-Br bond cleavage producing an ion pair followed by formation of a radical pair via electron transfer. The vinylic cation is proposed to stem directly from the indirectly populated lowest excited singlet state of bromostyrene with an energy of activation of 6.7 kcal/mol. Branching between proton loss and electron transfer in the resulting ion pair determines the ratio of cation- to radical-derived product. The E/Z-isomerization occurs in a separate process and does not involve C-Br bond cleavage.
Plasma Wake Accelerators: Introduction and Historical Overview (2017)

Fundamental questions on the nature of matter and energy have found answers thanks to the use of particle accelerators. Societal applications, such as cancer treatment or cancer imaging, illustrate the impact of accelerators in our current life. Today, accelerators use metallic cavities that sustain electric fields with values limited to about 100 MV/m. Because of their ability to support extreme accelerating gradients, the plasma medium has recently been proposed for future cavity-like accelerating structures. This contribution highlights the tremendous evolution of plasma accelerators driven by either laser or particle beams that allow the production of high quality particle beams with a degree of tunability and a set of parameters that make them very pertinent for many applications.
Nanofiber Matrices Promote the Neuronal Differentiation of Human Embryonic Stem Cell-Derived Neural Precursors <i>In Vitro</i> (2010)

The potential of human embryonic stem (ES) cells as experimental therapies for neuronal replacement has recently received considerable attention. In view of the organization of the mature nervous system into distinct neural circuits, key challenges of such therapies are the directed differentiation of human ES cell-derived neural precursors (NPs) into specific neuronal types and the directional growth of axons along specified trajectories. In the present study, we cultured human NPs derived from the NIH-approved ES line BGO1 on polycaprolactone fiber matrices of different diameter (i.e., nanofibers and microfibers) and orientation (i.e., aligned and random); fibers were coated with poly-L-ornithine/laminin to mimic the extracellular matrix and support the adhesion, viability, and differentiation of NPs. On aligned fibrous meshes, human NPs adopt polarized cell morphology with processes extending along the axis of the fiber, whereas NPs on plain tissue culture surfaces or random fiber substrates form nonpolarized neurite networks. Under differentiation conditions, human NPs cultured on aligned fibrous substrates show a higher rate of neuronal differentiation than other matrices; 62% and 86% of NPs become TUJ1 (+) early neurons on aligned micro- and nanofibers, respectively, whereas only 32% and 27% of NPs acquire the same fate on random micro- and nanofibers. Metabolic cell activity/viability studies reveal that fiber alignment and diameter also have an effect on NP viability, but only in the presence of mitogens. Our findings demonstrate that fibrous substrates serve as an artificial extracellular matrix and provide a microenviroment that influences key aspects of the neuronal differentiation of ES-derived NPs.
Bayesian inference of the number of factors in gene-expression analysis: application to human virus challenge studies (2010)

Applying the Beta Process to the factor scores, or to the singular values of a pseudo-SVD construction, the proposed algorithms infer the number of factors in gene-expression data. For real data the "true" number of factors is unknown; in our simulations we consider a range of noise variances, and the proposed Bayesian models inferred the number of factors accurately relative to other methods in the literature, such as sparse-PCA and PMD. We have also identified a "pan-viral" factor of importance for each of the three viruses considered in this study. We have identified a set of genes associated with this pan-viral factor, of interest for early detection of such viruses based upon the host response, as quantified via gene-expression data.
Do Intraoperative Radiographs in Scoliosis Surgery Reflect Radiographic Result? (2009)

Level IV, retrospective study. See Guidelines for Authors for a complete description of levels of evidence.
Componential set-based analysis (1999)

Set-based analysis (SBA) produces good predictions about the behavior of functional and object-oriented programs. The analysis proceeds by inferring constraints that characterize the data flow relationships of the analyzed program. Experiences with MrSpidey, a static debugger based on SBA, indicate that SBA can adequately deal with programs of up to a couple of thousand lines of code. SBA fails, however, to cope with larger programs because it generates systems of constraints that are at least linear, and possibility quadratic, in the size of the analyzed program. This article presents theoretical and practical results concerning methods for reducing the size of constraint systems. The theoretical results include of proof-theoretic characterization of the observable behavior of constraint systems for program components, and a complete algorithm for deciding the observable equivalence of constraint systems. In the course of this development we establish a close connection between the observable equivalence of constraint systems and the equivalence of regular-tree grammars. We then exploit this connection to adapt a variety of algoirthms for simplifying grammars to the problem of simplifying constraint systems. Based on the resulting algorithms, we have developed componential set-based analysis , a modular and polymorphic variant of SBA. Experimental results verify the effectiveness of the simplification algorithms and the componential analysis. The simplified constraint systems are typically an order of magnitude smaller than the original systems. These reductions in size produce significant gains in the speed of the analysis.
A Novel and Versatile Methodology for Functionalization of Conjugated Polymers. Transformation of Poly(3-bromo-4-hexylthiophene) via Palladium-Catalyzed Coupling Chemistry (2001)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTA Novel and Versatile Methodology for Functionalization of Conjugated Polymers. Transformation of Poly(3-bromo-4-hexylthiophene) via Palladium-Catalyzed Coupling ChemistryYuning Li, George Vamvounis, Jianfei Yu, and Steven HoldcroftView Author Information Department of Chemistry, Simon Fraser University, 8888 University Drive, Burnaby BC V5A 1S6, Canada Cite this: Macromolecules 2001, 34, 10, 3130–3132Publication Date (Web):April 11, 2001Publication History Received20 February 2001Published online11 April 2001Published inissue 1 May 2001https://pubs.acs.org/doi/10.1021/ma010293whttps://doi.org/10.1021/ma010293wrapid-communicationACS PublicationsCopyright © 2001 American Chemical SocietyRequest reuse permissionsArticle Views1216Altmetric-Citations70LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Chemical structure,Functional groups,Optical properties,Polymers Get e-Alerts
EFFECT OF NATURAL CONVECTION ON THE PROCESS OF MELTING AND SOLIDIFICATION OF PARAFFIN WAX (1987)

Abstract Temperature distribution and solid-liquid interface positions were measured during melting and solidification of paraffin wax (mixture of pentacosane and hexacosane) contained in a cylindrical cell, with an insulated wall to achieve one dimensional heat flow. The lower face of the cell was subjected to a sudden temperature change, while the condition of no heat flux was maintained at the upper face. Measurements of temperature distribution and interface positions during solidification from below were in excellent agreement with theoretical predictions based on pure conduction in both phases. Both the analytical solution of Neumann and the numerical solution of Murray and Landis were applied and found to have similar results. Although the experimental results of melting from below showed distinct temperature distribution in both phases, the agreement with the theoretical estimates based on pure conduction was very poor. In order to include the effect of convection, liquid thermal conductivity was replaced by an effective thermal conductivity according to a correlation of the form, KeK1 = cRo n . Values of c and n have been determined to achieve a good agreement between the experimental and theoretical values of the interface positions, and found to be different from those usually obtained with no phase change.
Diet high in linoleic acid dysregulates the intestinal endocannabinoid system and increases susceptibility to colitis in Mice (2023)

Inflammatory bowel disease (IBD) is a multifactorial disease with increasing incidence in the U.S. suggesting that environmental factors, including diet, are involved. It has been suggested that excessive consumption of linoleic acid (LA, C18:2 omega-6), which must be obtained from the diet, may promote the development of IBD in humans. To demonstrate a causal link between LA and IBD, we show that a high fat diet (HFD) based on soybean oil (SO), which is comprised of ~55% LA, increases susceptibility to colitis in several models, including IBD-susceptible IL10 knockout mice. This effect was not observed with low-LA HFDs derived from genetically modified soybean oil or olive oil. The conventional SO HFD causes classical IBD symptoms including immune dysfunction, increased intestinal epithelial barrier permeability, and disruption of the balance of isoforms from the IBD susceptibility gene Hepatocyte Nuclear Factor 4α (HNF4α). The SO HFD causes gut dysbiosis, including increased abundance of an endogenous adherent invasive <i>Escherichia coli</i> (AIEC), which can use LA as a carbon source. Metabolomic analysis shows that in the mouse gut, even in the absence of bacteria, the presence of soybean oil increases levels of LA, oxylipins and prostaglandins. Many compounds in the endocannabinoid system, which are protective against IBD, are decreased by SO both <i>in vivo</i> and <i>in vitro</i>. These results indicate that a high LA diet increases susceptibility to colitis via microbial and host-initiated pathways involving alterations in the balance of bioactive metabolites of omega-6 and omega-3 polyunsaturated fatty acids, as well as HNF4α isoforms.
Abstract 2899: Selinexor inhibits NF-κB activity by sequestering IkB-a in the nucleus and blocking IkB-a degradation (2016)

Abstract Background: Selinexor is a small-molecule therapeutic that inhibits XPO1 mediated nuclear export, resulting in nuclear accumulation of tumor suppressor proteins (TSPs) and subsequently cancer cell death while sparing normal cells. It has been previously demonstrated that the inhibitor of NFκB, IκB-, is localized to the cytoplasm by XPO1 in several cancer cell lines and that treatment of cancer cells with selinexor reduces NF-κB transcriptional activity. The mechanism of NF-κB inhibition by selinexor, however, is not fully understood. We hypothesized that nuclear retention of IκB- and down-regulation of IκB- kinase (IKK) in response to selinexor treatment would inhibit NF-κB transcriptional activity. Methods: U2OS (Osteosarcoma) cells were treated with selinexor in the presence or absence of TNF stimulation and whole protein lysates were analyzed by Western blotting. IκB- localization was evaluated by immunofluorescence microscopy and NF-κB transcriptional activity by ELISA (Thermo Scientific). Results: TNFα induced the phosphorylation of NF-κB p65 subunit on serine 536 and IκB- on serine 32/36 through IKK. This resulted in the dissociation of IκB-α from NF-κB and led to IκB-α degradation via the 26S proteasome. Free NF-κB could now migrate into the nucleus and initiate transcriptional activation supporting tumorigenicity and inflammation. The IKK kinase is a complex made of two kinases (IKKα and IKKβ) and one regulatory subunit, NEMO/IKKγ. We found that selinexor treatment blocked IKK activity through the down regulation of the IKK (IKKγ) gamma subunit protein levels. This inhibition was dose dependent and prevented IκB- phosphorylation, thereby protecting IκB- from degradation. The protection of intact IκB- from degradation and its forced nuclear accumulation through XPO1 inhibition enabled inhibition of NF-κB transcriptional activity even in the presence of TNFα. Selinexor did not alter the protein levels of IKK or IKK. Conclusions: Selinexor blocks TNFα induced degradation of IκB- by reducing the levels of IKK. In addition, selinexor increased nuclear IκB- levels through the inhibition of nuclear export. This blocked NF-κB activity and enhanced cancer cell death. We are currently investigating the beneficial effects of combining selinexor with proteasome inhibitors, which are known to prevent IκB- degradation. Citation Format: Trinayan Kashyap, Christian Argueta, Boris Klebanov, TJ Unger, Benjamin Link, Maxwell Werman, Margaret Lee, Sharon Shacham, Yosef Landesman. Selinexor inhibits NF-κB activity by sequestering IkB-a in the nucleus and blocking IkB-a degradation. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 2899.
Passive Smart Phone Indentification and Tracking with Application Set Fingerprints (2013)

Current smart phone users can be identified and tracked by fingerprint techniques. Fingerprint identification techniques can be used for legitimate purposes such as network management and traffic control to avoid excessive congestion. This paper proposes a user identification and tracking technique specific to smart phone users for supervised network management. This paper proposes the application set fingerprint, which is a simple set of User-Agent request-header fields in HTTP sessions. The application set fingerprint has three advantages, fully-passive fingerprint generation, potential of user trackability, and fingerprinting considering the users' privacy. The results show that the application set fingerprint is practically effective and network operators can use it for tracking smart phone users with the purpose of efficient network management.
Insights into the effect of a craniotomy on the impact resistance of the skull (2019)

Craniotomy is a well-known procedure in neurosurgery, during which a bone flap is removed, and is mainly used to save patients with severe head trauma (Chaikoolvatana and Sripech 2007). They can al...
Second-Order Adversarial Attack and Certifiable Robustness (2018)

We propose a powerful second-order attack method that outperforms existing attack methods on reducing the accuracy of state-of-the-art defense models based on adversarial training. The effectiveness of our attack method motivates an investigation of provable robustness of a defense model. To this end, we introduce a framework that allows one to obtain a certifiable lower bound on the prediction accuracy against adversarial examples. We conduct experiments to show the effectiveness of our attack method. At the same time, our defense models obtain higher accuracies compared to previous works under our proposed attack.
Digital Beamforming on Receive: Techniques and Optimization Strategies for High-Resolution Wide-Swath SAR Imaging (2009)

Synthetic Aperture Radar (SAR) is a well-proven imaging technique for remote sensing of the Earth. However, conventional SAR systems are not capable of fulfilling the increasing demands for improved spatial resolution and wider swath coverage. To overcome these inherent limitations, several innovative techniques have been suggested which employ multiple receive-apertures to gather additional information along the synthetic aperture. These digital beamforming (DBF) on receive techniques are reviewed with particular emphasis on the multi-aperture signal processing in azimuth and a multi-aperture reconstruction algorithm is presented that allows for the unambiguous recovery of the Doppler spectrum. The impact of Doppler aliasing is investigated and an analytic expression for the residual azimuth ambiguities is derived. Further, the influence of the processing on the signal-to-noise ratio (SNR) is analyzed, resulting in a pulse repetition frequency (PRF) dependent factor describing the SNR scaling of the multi-aperture beamforming network. The focus is then turned to a complete high-resolution wide-swath SAR system design example which demonstrates the intricate connection between multi-aperture azimuth processing and the system architecture. In this regard, alternative processing approaches are compared with the multi-aperture reconstruction algorithm. In a next step, optimization strategies are discussed as pattern tapering, prebeamshaping-on-receive, and modified processing algorithms. In this context, the analytic expressions for both the residual ambiguities and the SNR scaling factor are generalized to cascaded beamforming networks. The suggested techniques can moreover be extended in many ways. Examples discussed are a combination with ScanSAR burst mode operation and the transfer to multistatic sparse array configurations.
Protocol for prenatal diagnosis of cystic fibrosis based on studies of alkaline phosphatase isoenzymes. (1988)

Amniotic fluid analysis of microvillar enzymes, including alkaline phosphatase (ALP) total activity and ALP isoenzymes, has been widely experimented with and used for the prenatal diagnosis of cystic fibrosis in the second trimester of gestation. Since the development of cystic fibrosis molecular analysis, interest in these biochemical tests has been maintained for those instances in which the pregnancy is not fully informative by restriction fragment length polymorphism analysis or DNA is not available from the index-affected child. However, recommended biochemical protocols do not provide clear-cut diagnostic results in a minority of cases. We have tested the reliability of cystic fibrosis biochemical prediction by ALP high-resolution electrophoresis and ALP kinetic studies after inactivation by urea. With this approach, all the amniotic fluid samples that had not been unambiguously classified as affected or unaffected by standard microvillar enzymes analysis were definitely categorized. The proposed method seems to improve the diagnostic accuracy in pregnancies with a one in four risk of resulting in a child with cystic fibrosis.
Induction Machine Equations in Phase Quantities: Assisted by Space Vectors (2014)

In ac machines, the stator windings are intended to have a sinusoidally distributed conductor density in order to produce a sinusoidally distributed field distribution in the air gap. In the squirrel-cage rotor of induction machines, the bar density is uniform. This chapter reviews the sinusoidally distributed windings and then calculated their inductances for developing equations for induction machines in phase (a-b-c) quantities. The development of these equations is assisted by space vectors, which are briefly reviewed. The chapter establishes the framework and the rationale for the dq windings-based analysis of induction machines under dynamic conditions. It also assumes that the magnetic material in the stator and the rotor is operated in its linear region and has an infinite permeability.
Recognition of Wrist Motion Pattern by EMG (2006)

Recently, studies of artificial arms and pointing devices using ElectroMyoGram(EMG) have been actively done. However, the individual variation of EMG is large, and its repeatability is low. Furthermore, EMG is usually measured from a part with comparatively big muscular fibers such as arms and shoulders. Therefore, if we can recognize wrist operations using EMG which was measured from the wrist, the range of application will extend furthermore. In this study, we aim toward the development of a device of wristwatch type that consolidates operational interface of various equipments. In particular, as an early stage, we propose a wrist motion recognition system. First, we execute the Fourier transform to the signal for feature extraction. Next, we experiment it by using neural networks after the dimensional reduction by using Simple-PCA and Simple-FLDA to reduce the number of inputs to NN. It was confirmed that the present approach was one of the techniques which were effective in the wrist recognition experiment.
Quantificação dos níveis de inibidor de tripsina em folhas de eventos de soja GM com fator de transcrição ABA induzido. (2018)

Made available in DSpace on 2018-07-23T14:40:49Z (GMT). No. of bitstreams: 1\nQuantificacaodosniveisp.675678.pdf: 321691 bytes, checksum: 75346d0f9a369ad68249769d59937d95 (MD5)\n Previous issue date: 2018-07-23
Slowing DNA Translocation through Nanopores Using a Solution Containing Organic Salts (2009)

One of the key challenges to nanopore DNA sequencing is to slow down DNA translocation. Here, we report that the translocation velocities of various DNA homo- and copolymers through protein pores could be significantly decreased by using electrolyte solutions containing organic salts. Using a butylmethylimidazolium chloride (BMIM-Cl) solution instead of the commonly used KCl solution, DNA translocation rates on the order of hundreds of microseconds per nucleotide base were achieved. The much enhanced resolution of the nanopore coupled with different event blockage amplitudes produced by different nucleotides permits the convenient differentiation between various DNA molecules.