gebhart/patrepeval huggingface dataset:
Synthesis of poly(γ‐methoxypropylmethylsilylene) and poly(γ‐methoxypropylmethylsilylene‐co‐di‐<i>n</i>‐hexylsilylene) (1994)

Abstract The synthesis of γ;‐methoxypropylmethyldichlorosilane, and its subsequent polymerization and copolymerization with di;‐ n ;‐hexyldichlorosilane through the reductive coupling with sodium has been accomplished. The resulting polymers contain methyl ether side groups that allow further synthetic transformations on the polysilane backbone. For poly (γ;‐methoxypropylmethylsilylene) these groups impart solubility characteristics different than typical alkyl and aryl substituted polysilanes. These new polymers and copolymers have been characterized by GPC and 1 H‐, 13 C‐, and 29 Si‐NMR. © 1994 John Wiley &amp; Sons, Inc.
Site-specific modification of apolipoprotein B by advanced glycosylation end-products: implications for lipoprotein clearance and atherogenesis (1996)

An AGE-modified form of LDL (AGE-LDL) circulates in patients with diabetes mellitus or renal insufficiency and shows impaired plasma clearance kinetics when injected into transgenic mice that express the human LDL receptor. The advanced glycosylation inhibitor aminoguanidine decreases plasma LDL in diabetic patients, further suggesting that the AGE modification of LDL contributes significantly to increased LDL in vivo. We utilized AGE-specific antibodies to identify the major site(s) of AGE modification within apolipoprotein B (apoB), which impairs the binding of AGE-LDL by human fibroblast LDL receptors. Despite the large size of apoB (4536 amino acid residues) and its high content of potentially reactive lysines, the predominant site of AGE-immunoreactivity was found to lie within a single 67 amino acid domain located 1791 residues N-terminal to the LDL receptor binding site. These data point to the high specificity and reactivity of this site toward AGE formation and to a significant structural interaction between this region of apoB and the LDL receptor binding domain. A low but detectable degree of AGE modification was found to affect this site in LDL which was isolated from normal, non-diabetic individuals, suggesting that advanced glycosylation may contribute to elevated LDL in the general population as well.
The Relationship of Athlete-Reported Concussion Symptoms and Objective Measures of Neurocognitive Function and Postural Control (2009)

These findings indicate self-report symptoms are associated with athlete deficits in postural control and cognitive function. The moderate relationship between the symptom reports and the objective measures warrants the continued use of all measures. A reduction in the number of symptoms concussed athletes respond to may be justified to reduce redundancy.
Coingestion of Acylglycerols Differentially Affects Glucose-Induced Insulin Secretion via Glucose-Dependent Insulinotropic Polypeptide in C57BL/6J Mice (2009)

The precise role of fat in postprandial glycemia and insulinemia has not been thoroughly researched because postprandial blood glucose and concurrent insulin secretion are largely assumed to be proportional to carbohydrate intake. Recent studies have suggested that dietary fat differentially regulates the postprandial insulin response. To explore this, we examined the effects of coadministered fat on glucose-induced glycemia and insulinemia in C57BL/6J mice. The insulin response to glucose was augmented by the addition of glycerol trioleate (TO) in a dose-dependent manner, which was associated with enhanced glucose transport from the circulation to muscle and adipose tissues. To investigate the mechanism underlying fat-induced hyperinsulinemia, we examined the release of the incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1. TO increased GIP secretion, whereas glucagon-like peptide-1 secretion was unaffected. TO-induced hyperinsulinemia was significantly attenuated by the pretreatment of mice with a specific GIP antagonist. Diacylglycerol (DAG) promoted lower postprandial GIP and triglyceride responses and, when ingested with glucose, a lower insulin response compared with triacylglycerol of a similar fatty acid composition. Pluronic L-81, an inhibitor of chylomicron formation, reduced not only the triglyceride response but also TO-induced GIP secretion, indicating that the lower GIP response after DAG ingestion may be associated with retarded chylomicron formation in the small intestine. We conclude that dietary fat augments glucose-induced insulinemia via gut-derived GIP and, thereby, influences postprandial nutrient metabolism in mice. DAG promotes a lower GIP and thereby reduced insulin responses compared with triacylglycerol, which may differentially influence postprandial energy homeostasis.
Retinal effects of the frequency‐doubled (532 nm) YAG laser: Histopathological comparison with argon laser (1985)

Retinal lesions produced in Dutch Cross rabbits with a frequency-doubled (532 nm) YAG laser in single pulse mode (30-100 microJ) and in train of uniform pulses (2.6 and 7.5 mJ) underwent histopathological examination by light and electron microscopy. The results were compared to argon laser lesions (11 and 15 mJ) in the same animals. Low-energy single-pulse YAG lesions produced separation of the neural retina from the retinal pigmented epithelium (RPE), while higher energies caused severe disruption of retinal structures with moderate damage to the RPE. A striking and consistent finding of all the single-pulse lesions was the presence of red blood cells between the RPE and neural layers. The findings appear to support a process of mechanical disruption. In contrast, the lesions produced by a uniform train of pulses showed well-defined damage to RPE and photoreceptors with no red blood cells between these two layers, no choroidal damage, and relatively little disruption of the inner retina. The typical argon lesion evidenced cellular damage from the RPE through all retinal layers. Leukocytes in the choroid contained "holes" or vacuoles not seen in YAG lesions. Both the uniformly pulsed YAG laser burst and argon laser produced effects consistent with a thermal process. Some differences between argon and YAG burst were observed. The results suggest that there may be a clinical potential for the 532-nm burst YAG in treating retinopathies.
The Microenvironment-Specific Transformation of Adult Stem Cells Models Malignant Triton Tumors (2013)

Here, we demonstrated the differentiation potential of murine muscle-derived stem/progenitor cells (MDSPCs) toward myogenic, neuronal, and glial lineages. MDSPCs, following transplantation into a critical-sized sciatic nerve defect in mice, showed full regeneration with complete functional recovery of the injured peripheral nerve at 6 weeks post-implantation. However, several weeks after regeneration of the sciatic nerve, neoplastic growths were observed. The resulting tumors were malignant peripheral nerve sheath tumors (MPNSTs) with rhabdomyoblastic differentiation, expressing myogenic, neurogenic, and glial markers, common markers of human malignant triton tumors (MTTs). No signs of tumorigenesis were observed 17 weeks post-implantation of MDSPCs into the gastrocnemius muscles of dystrophic/mdx mice, or 1 year following subcutaneous or intravenous injection. While MDSPCs were not oncogenic in nature, the neoplasias were composed almost entirely of donor cells. Furthermore, cells isolated from the tumors were serially transplantable, generating tumors when reimplanted into mice. However, this transformation could be abrogated by differentiation of the cells toward the neurogenic lineage prior to implantation. These results establish that MDSPCs participated in the regeneration of the injured peripheral nerve but transformed in a microenvironment- and time-dependent manner, when they likely received concomitant neurogenic and myogenic differentiation signals. This microenvironment-specific transformation provides a useful mouse model for human MTTs and potentially some insight into the origins of this disease.
Recent advances in the characterization and the treatment methods of effluent organic matter (2020)

There are many previous review articles are available to summarize either the characterization methods of effluent organic matter (EfOM) or the individual control treatment options. However, there has been no attempt made to compare in parallel the physicochemical treatment options that target the removal of EfOM from biological treatments. This review deals with the recent progress on the characterization of EfOM and the novel technologies developed for EfOM treatment. Based on the publications after 2010, the advantages and the limitations of several popularly used analytical tools are discussed for EfOM characterization, which include UV-visible and fluorescence spectroscopy, Fourier transform infrared spectroscopy (FTIR), size exclusion chromatography (SEC), and Fourier transform-ion cyclotron resonance-mass spectrometry (FT-ICR-MS). It is a recent trend to combine an SEC system with various types of detectors, because it can successfully track the chemical/functional composition of EfOM, which varies across a continuum of different molecular sizes. FT-ICR-MS is the most powerful tool to detect EfOM at molecular levels. However, it is noted that this method has rarely been utilized to understand the changes of EfOM in pre-treatment or post-treatment systems. Although membrane filtration is still the preferred method to treat EfOM before its discharge due to its high separation selectivity, the minimum requirements for additional chemicals, the ease of scaling up, and the continuous operation, recent advances in ion exchange and advanced oxidation processes are greatly noteworthy. Recent progress in the non-membrane technologies, which are based on novel materials, are expected to enhance the removal efficiency of EfOM and even make it feasible to selectively remove undesirable fractions/compounds from bulk EfOM.
Discrete spatial soliton formation in a two-dimensional fs laser written waveguide array in fused silica (2006)

We report on the observation of a two-dimensional discrete soliton in a cubic 5 × 5 fs laser written waveguide array for the first time. In addition to the localization the sharp defined edges of the array allow to study the influence of the array's boundaries. The results are in excellent agreement with the theoretical predictions. These results provide the basis for a variety of future applications for nonlinear two-dimensional integrated optical devices.
Design and Testing of Multistage Centrifugal Compressors With Small Diffusion Ratios (2008)

Two stators of a multistage centrifugal compressor with progressively smaller outer radii have been designed, built and tested. The aim was to achieve a significant reduction in outer diameter of the compressor stage without compromising performance. The reduction of size was achieved by reducing the diffusion ratio (outer radius/inner radius) of the vaneless diffuser in two steps. In the first step the outer diameter of the entire stage was reduced by 8% compared to the baseline design. In the second stage the outer diameter was reduced by 14%. The outer radius of the smallest design was limited by the impeller exit diameter, which was kept constant, as was the axial length of the stage. The large radius baseline design has been tested on a rotating rig in a 1.5 stage setup. This setup aimed at simulating multistage behavior by applying a pseudo stage upstream of the main stage. The pseudo stage consisted of a set of non-rotating preswirl vanes, in order to mimic an upstream impeller, and was followed by a scaled version of the return channel of the main stage. The experimental database was then used to calibrate a 1D analysis code and 3D-CFD methods for the ensuing design and optimization part. By applying extensive Design-Of-Experiments (DOE), the endwalls as well as the vanes of the stator part were optimized for maximum efficiency and operation range. In order to preserve multistage performance, the optimization was constrained by keeping the circumferentially averaged spanwise flow profiles at the exit of the smaller radius stages within close limits to the original design. The reduced radius designs were then tested in the same 1.5 stage setup as the baseline design. The results indicate that the reduction in size was feasible without compromising efficiency and operation range of the stage.
Sensitivity-based adaptive SRUKF for online state, parameter, and process covariance estimation (2017)

State estimation is applicable to almost all areas of engineering and science. Applications that include a physical-parametric model of a system are candidates for state estimation. These estimators reconstruct the system states based on a system model and information received from the system sensors. The most widely applied state estimators are the Kalman Filter (KF) derivatives. These filters use a parametric system model, system measurements and input information, and require knowledge about the noise statistics affecting the system. These noise statistics are often unknown and inaccurate filter tuning may lead to decreased filter performance or even filter divergence. These estimators can be extended to estimate parameters. However, insufficient system excitation can cause parameter estimation drifts. In this paper, a sensitivity-based adaptive Square-Root Un-scented Kalman Filter (SRUKF) is presented. This filter estimates system states, parameters and noise covariances online. Moreover, local sensitivity analysis is performed to prevent parameter estimation drifts during phases of insufficient system excitation. The filter is evaluated on two testbeds based on an axis serial mechanism and compared with the joint SRUKF.
Layered LDPC Decoding Over $GF(q)$ for Magnetic Recording Channel (2009)

This paper proposes a layered decoding algorithm for the low-density parity-check (LDPC) codes over <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">GF</i> ( <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">q</i> ). The layered decoding can be applied to parity-check matrices that are structured in layers, such as quasi-cyclic (QC) parity-check matrices. When simulated over a magnetic recording channel, the layered decoder outperforms the conventional decoder in the number of inner iterations and in the block error rate.
Valuing flexible operating strategies in nickel production under uncertainty (2013)

With increasing global demand for nickel (which is a key component of stainless steel) the focus of mineral industry is currently on the abundant low-grade nickel laterite reserves. The extraction of nickel from the low-grade laterites is a technically difficult and expensive process and, as a result, the profitability of nickel production projects is highly affected by uncertainty over future market conditions. The project value can be increased by utilizing flexible operating strategies in response to changing future market conditions and Real Options analysis provides a suitable tool for optimizing flexible operating strategies over a long planning horizon in the face of uncertainty.
Increasing the convergence rate of distributed beamforming (2011)

In this paper we discuss techniques for Distributed Beamforming (DBF). We specify a generic communication scenario in which a DBF scheme should function to be of practical significance. We identify need for improvement in recently proposed DBF schemes in order to operate reliably in realistic scenarios, and propose a new algorithm which incorporates such improvements. We show by simulations that our new algorithm significantly outperforms the previous approaches in terms of speef of convergence and reliability of operation.
Targeted Intracellular Demethylation of Methylmercury Enhances Elimination Kinetics and Reduces Developmental Toxicity in Transgenic<i>Drosophila</i> (2022)

Methylmercury (MeHg) persists today as a priority public health concern. Mechanisms influencing MeHg metabolism, kinetics, and toxicity outcomes are therefore essential knowledge for informing exposure risks. Evidence points to different toxic potencies of MeHg and inorganic mercury (Hg2+), highlighting the role for biotransformation (demethylation) in regulating MeHg toxicokinetics/dynamics. Whereas microbial MeHg demethylation in the gut is seen to influence elimination kinetics, the potential for systemic demethylation in tissues and target organs to influence MeHg toxicity remains uncertain. To investigate the consequences of systemic MeHg demethylation across development, we engineered transgenic Drosophila to express the bacterial organomercurial lyase enzyme (merB) in a targeted and tissue-specific manner. With all combinations of merB-induced demethylation, ubiquitously (via an actin promoter) or in a tissue-specific manner (ie, gut, muscle, neurons), we observe a rescue of MeHg-induced eclosion failure at the pupal to adult transition. In MeHg-fed larvae with ubiquitous or targeted (gut and muscle) merB expression, we see a significant decrease in MeHg body burden at the pupal stage relative to control flies. We also observe a significant increase in the MeHg elimination rate with merB demethylation induced in adults (control, t1/2 = 7.2 days; merB flies, t1/2 = 3.1 days). With neuronal-specific merB expression, we observe a rescue of MeHg-induced eclosion failure without a decrease in Hg body burden, but a redistribution of Hg away from the brain. These results demonstrate the previously unidentified potential for intracellular MeHg demethylation to promote transport and elimination of Hg, and reduce developmental MeHg toxicity. Impact Statement: These findings demonstrate the potential for MeHg demethylation in situ to contribute significantly to the MeHg elimination and distribution kinetics of whole animals and thereby affords a means of protection against the toxic insult of MeHg. Therefore, this study reveals important insight into processes that can determine an individual's resistance or susceptibility to MeHg and provides rationale for therapies targeting a novel metabolism-based pathways to alleviate toxicity risk stemming from MeHg exposure.
<i>In vitro</i> characteristics of a gelling PEGDA‐QT polymer system with model drug release for cerebral aneurysm embolization (2013)

A liquid-to-solid gelling polymer system, such as the poly(ethylene glycol) diacrylate-pentaerythritol tetrakis (3-mercaptopropionate) (PEGDA-QT) system, can fill cerebral aneurysms more completely than current embolization materials, reducing the likelihood of aneurysm recurrence. PEGDA-QT gels were formulated using PEGDA of different molecular weights (PEGDA575 and PEGDA700), and their characteristics were examined in vitro. Experiments examined gel time, mass change, crosslink integrity, cytotoxicity, and protein release capabilities. In general, PEGDA575-QT gels were more hydrophobic, requiring an initiating solution with a higher pH (pH 9.5) to achieve a gel time comparable to PEGDA700-QT gels, which used an initiating solution at pH 9.19. The mass change and crosslink integrity of gels were analyzed over time after gels were submerged in 150 mM phosphate buffered saline. After 380 days, PEGDA575-QT gels achieved a maximum mass increase of 72% due to water uptake, while PEGDA700-QT gels doubled their initial mass (100% increase) by 165 days. Compression tests showed that PEGDA700-QT gels hydrolyzed more quickly than PEGDA575-QT gels. Cytotoxicity assays showed that in general, PEGDA575-QT negatively affected cell growth, while PEGDA700-QT gels promoted cell viability. Sustained, controlled release of lysozyme, a 14.3 kDa protein, was achieved over an 8-week period when loaded into PEGDA700-QT gels, but PEGDA575-QT gels did not show sustained release. These studies show that although they are similar in composition, these PEGDA-QT gel formulations behave considerably differently. Although PEGDA700-QT gels swell more and degrade faster than PEGDA575-QT gels, their cytocompatibility and protein release characteristics may prove to be more beneficial for in vivo aneurysm treatment.
Thiol–yne ‘click’ chemistry as a route to functional lipid mimetics (2010)

Thiol–alkyne ‘click’ chemistry is a modular, efficient mechanism to synthesize complex A2B 3-arm star polymers. This general motif is similar to a phospholipid where the A blocks correspond to lypophilic chains and the B block represents the polar head group. In this communication we employ thiol–yne chemistry to produce polypeptide-based A2B lipid mimetics. The utility of the thiol–yne reaction is demonstrated by using a divergent and a convergent approach in the synthesis. These polymers self-assemble in aqueous solution into spherical vesicles with a relatively narrow size distribution independent of block composition over the range studied. Using the thiol–yne convergent synthesis, we envision a modular approach to functionalize proteins or oligopeptides with lipophilic chains that can imbed seamlessly into a cell membrane.
Intel nGraph: An Intermediate Representation, Compiler, and Executor for Deep Learning (2018)

The Deep Learning (DL) community sees many novel topologies published each year. Achieving high performance on each new topology remains challenging, as each requires some level of manual effort. This issue is compounded by the proliferation of frameworks and hardware platforms. The current approach, which we call "direct optimization", requires deep changes within each framework to improve the training performance for each hardware backend (CPUs, GPUs, FPGAs, ASICs) and requires $\mathcal{O}(fp)$ effort; where $f$ is the number of frameworks and $p$ is the number of platforms. While optimized kernels for deep-learning primitives are provided via libraries like Intel Math Kernel Library for Deep Neural Networks (MKL-DNN), there are several compiler-inspired ways in which performance can be further optimized. Building on our experience creating neon (a fast deep learning library on GPUs), we developed Intel nGraph, a soon to be open-sourced C++ library to simplify the realization of optimized deep learning performance across frameworks and hardware platforms. Initially-supported frameworks include TensorFlow, MXNet, and Intel neon framework. Initial backends are Intel Architecture CPUs (CPU), the Intel(R) Nervana Neural Network Processor(R) (NNP), and NVIDIA GPUs. Currently supported compiler optimizations include efficient memory management and data layout abstraction. In this paper, we describe our overall architecture and its core components. In the future, we envision extending nGraph API support to a wider range of frameworks, hardware (including FPGAs and ASICs), and compiler optimizations (training versus inference optimizations, multi-node and multi-device scaling via efficient sub-graph partitioning, and HW-specific compounding of operations).
Surface hardening by anodizing and heat treatments of Ti6Al4V alloys for articular prostheses. (2002)

This paper presents a study of the surface hardening of Ti6Al4V alloy produced by electrochemical anodizing and by different heat treatments, in addition to studying the annealing of the martensitic structure. Results of the combination of both methods produce hardening over 1300 HV and an important improvement on the tribological behaviour. These values could improve wear resistance of this alloy in applications like articular prostheses.
External drainage of bile and pancreatic juice after endoscopic submucosal dissection for duodenal neoplasm: Feasibility study (with video) (2020)

Endoscopic nasobiliary and nasopancreatic duct drainage is technically feasible and might provide effective prophylaxis for delayed adverse events, even if a large mucosal defect is present after ESD.