gebhart/patrepeval huggingface dataset:
Reply to Comment on Watanabe, A.; Kadota, Y.; Yokoyama, H.; Tsuruda, S.; Kamio, R.; Tochio, T.; Shimomura, Y.; Kitaura, Y. Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats. Foods 2020, 9, 4 (2020)

The manuscript entitled "Comment on Experimental Determination of the Threshold Dose for Bifidogenic Activity of Dietary 1-Kestose in Rats" by Shen et al [...].
Combining Cohort and UBM Models in Open Set Speaker Identification (2009)

In open set speaker identification it is important to build an alternative model against which to compare scores from the 'target' speaker model. Two alternative strategies for building an alternative model are to build a single global model by sampling from a pool of training data, the Universal Background (UBM), or to build a cohort of models from selected individuals in the training data for the target speaker. The main contribution in this paper is to show that these approaches can be unified by using a Support Vector Machine (SVM) to learn a decision rule in the score space made up of the output scores of the client, cohort and UBM model.
가중 변별 상관필터를 이용한 영상 추적 (2016)

In this paper, we propose the novel tracking method which uses the weighted discriminative correlation filter (DCF). We also propose the PSPR instead of conventional PSR as tracker performance evaluation method. The proposed tracking method uses multiple DCF to estimates the target position. In addition, our proposed method reflects more weights on the correlation response of the tracker which is expected to have more performance using PSPR. While existing multi-DCF-based tracker calculates the final correlation response by directly summing correlation responses from each tracker, the proposed method acquires the final correlation response by weighted combining of correlation responses from the selected trackers robust to given environment. Accordingly, the proposed method can provide high performance tracking in various and complex background compared to multi-DCF based tracker. Through a series of tracking experiments for various video data, the presented method showed better performance than a single feature-based tracker and also than a multi-DCF based tracker.
Thrombolytische Therapie des akuten Herzinfarktes (1994)

Zusammenfassung Im Rahmen der vorliegenden Metaanalyse wurden die Daten von ungefähr 100000 Patienten mit akutem Myokardinfarkt (AMI) aus 300 klinischen Thrombolysestudien ausgewertet. In einer vergleichenden Analyse wurden vor allem die Effektivität der gegenwärtig angewandten Plasminogenaktivatoren und der Einfluß einer frühen gegenüber einer späten begleitenden Heparintherapie geprüft. Eine frühzeitige Wiedereröffnung thrombotisch verschlossener Koronarien konnte mit den neuen Plasminogenaktivatoren oder mit intrakoronarer Lyse signifikant häufiger erreicht werden als mit intravenöser Streptokinaseinfusion. Die kumulativen Krankenhaussterblichkeitsraten lagen zwischen 4% und 9%. Die Ergebnisse der Metaanalyse lassen darauf schließen, daß der frühzeitige Beginn der Antikoagulanzienbehandlung mit Heparin für die thrombolytische Therapie mit rt-PA obligatorisch ist. Der Zeitpunkt des Beginns der prophylaktischen Antikoagulation bei der Thrombolysebehandlung mit Streptokinase oder APSAC beeinflußte das Therapieergebnis nicht signifikant. Die thrombolytische Behandlung mit intravenös verabreichtem rt-PA war signifikant gegenüber allen derzeitig angewandten thrombolytischen Behandlungsstrategien überlegen, wenn eine effektive antithrombotische Therapie stattfand.
Scalable and Fast Lazy Persistency on GPUs (2020)

GPUs applications, including many scientific and machine learning applications, increasingly demand larger memory capacity. NVM is promising higher density compared to DRAM and better future scaling potentials. Long running GPU applications can benefit from NVM by exploiting its persistency, allowing crash recovery of data in memory. In this paper, we propose mapping Lazy Persistency (LP) to GPUs and identify the design space of such mapping. We then characterize LP performance on GPUs, varying the checksum type, reduction method, use of locking, and hash table designs. Armed with insights into the performance bottlenecks, we propose a hash table-less method that performs well on hundreds and thousands of threads, achieving persistency with nearly negligible (2.1%) slowdown for a variety of representative benchmarks. We also propose a directive-based programming language support to simplify programming effort for adding LP to GPU applications.
METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance (2022)

Protein methylation occurs predominantly on lysine and arginine residues, but histidine also serves as a methylation substrate. However, a limited number of enzymes responsible for this modification have been reported. Moreover, the biological role of histidine methylation has remained poorly understood to date. Here, we report that human METTL18 is a histidine methyltransferase for the ribosomal protein RPL3 and that the modification specifically slows ribosome traversal on Tyr codons, allowing the proper folding of synthesized proteins. By performing an in vitro methylation assay with a methyl donor analog and quantitative mass spectrometry, we found that His245 of RPL3 is methylated at the τ-<i>N</i> position by METTL18. Structural comparison of the modified and unmodified ribosomes showed stoichiometric modification and suggested a role in translation reactions. Indeed, genome-wide ribosome profiling and an in vitro translation assay revealed that translation elongation at Tyr codons was suppressed by RPL3 methylation. Because the slower elongation provides enough time for nascent protein folding, RPL3 methylation protects cells from the cellular aggregation of Tyr-rich proteins. Our results reveal histidine methylation as an example of a ribosome modification that ensures proteome integrity in cells.
Supervised Stereo Visual Acuity Tests Implemented on 3D TV Monitors (2012)

In this paper we discuss under which conditions standard stereo visual acuity tests can be implemented on 3D TV monitors. In particular, we emphasize the role of environmental lighting conditions, on the measurement of the stereo visual acuity, when using conventional Stereoscopic 3D tests, such as Wirt stereotests. We investigate the impact of parameters such as luminance, backlight and contrast when these tests are implemented on 3D TV monitors. We demonstrate that some deviations are observed when modifying the room luminance and the type of displays used (e.g. plasma (PDP) or liquid crystal (LCD) displays). Our measurements carried out on an human sample are supervised by pupil size measurements, using an eyes-tracker, enabling a better interpretation of the results. Finally, we discuss the benefit of using Stereoscopic 3D tools to implement stereo visual acuity measurements.
A Code for Optimising Triplet Layout (2017)

One of the main challenges when designing final focus systems of particle accelerators is maximising the beam stay clear in the strong quadrupole magnets of the inner triplet. Moreover it is desirable to keep the quadrupoles in the inner triplet as short as possible for space and costs reasons but also to reduce chromaticity and simplify corrections schemes. An algorithm that explores the triplet parameter space to optimise both these aspects was written. It uses thin lenses as a first approximation for a broad parameter scan and MADX for more precise calculations. The thin lens algorithm is significantly faster than a full scan using MADX and relatively precise at indicating the approximate area where the optimum solution lies.
Optical regenerative amplifier based on amplification of femtosecond chirped laser pulse (2005)

A regenerative amplifier based on parametric amplification of a chirped femtosecond signal pulse and pumped by a nanosecond frequency doubled Q-switched Nd :YAG laser is demonstrated. The amplified signal pulses are bandwidth limited.
Pitch Scaling and Speech Understanding by Patients Who Use the Ineraid Cochlear Implant (1990)

Pitch scaling was assessed for 10 normal-hearing listeners and 8 patients who use the Ineraid multichannel cochlear implant. For two patients who were excellent users of the prosthesis, pitch increased over a wide range of frequencies (100 Hz to 2333-3000 Hz). For three patients who were above average users of the prosthesis, pitch increased with frequency over a smaller range (100 Hz to 1200-2300 Hz). For three patients who demonstrated poor word recognition ability, pitch increased with frequency over a very small range (100 Hz to 600-1000 Hz). These results suggest that differences in speech understanding among patients who use the Ineraid may be accounted for, in part, by the range of pitch available through the implant.
[Molecular genetics: a new approach of clinical neurosciences]. (1991)

Genetically determined diseases with neurological expression are frequent. Recent progress in molecular biological techniques, particularly the availability of markers distributed throughout the whole human genome, has given birth to the concept of reverse genetics, with consists in localizing the gene responsible for a disease, then identifying it and its corresponding protein. This approach is illustrated by the studies that led to the localization of the gene responsible for Huntington's chorea on the short arm of chromosome 4 and the identification of dystrophic, the abnormal gene product in Duchenne's and Becker's muscular dystrophies. These discoveries have medical repercussions, leading to predictive tests or new therapies. However, predictive medicine raises ethical issues that are largely debated.
ChemInform Abstract: Catalytic Enantioselective Approach to the Eudesmane Sesquiterpenoids: Total Synthesis of (+)‐Carissone. (2009)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Direct Casting of Polymer Membranes into Microfluidic Devices (2004)

ABSTRACTFully functional lab-on-a-chip devices for biological analyses require the capability for cell culture, separation, and purification, as well as analyses to be integrated on a single platform. To date, a great deal of research has been focused on analytical methods for the miniaturization of column-based separations. We have created a platform that provides the capability of including membrane separations as an intermediate stage in such devices. Our techniques adapt conventional silicon processing methods to the casting of membranes directly onto the silicon substrate through a wet inversion process. This process allows precise control of membrane thickness and pore size distribution based on the processing conditions. Using this methodology, we were able to fabricate devices that were found to be very robust with molecular weight cutoffs of approximately 350 Da as measured by solute flux in a dialysis mode of operation. These devices were also found to be suitable for cell culture, as evidenced by the high viability of fibroblasts grown within our device. On the basis of these results, a wide range of separations and coculture applications are possible.Key Words: Polymer membranesMicrofluidic devicesBiological analysesCell cultureMolecular separationLab-on-a-chip
A first generation Atlantic halibut <i>Hippoglossus hippoglossus </i>(L.) microarray: application to developmental studies (2008)

An oligonucleotide microarray containing 50‐mer oligonucleotides representing 9277 unique Atlantic halibut Hippoglossus hippoglossus genes has been designed, printed and is currently being used for the study of gene expression in developing halibut. The oligonucleotides are based on all the Atlantic halibut data available at the time of printing, these included expressed sequence tags (ESTs) and complete cDNAs derived from the Pleurogene sequencing project as well as sequences deposited in GenBank by other groups as of September 2006. Of the Pleurogene ESTs, 5040 are functionally annotated; the remainder are unknown (1016) or are similar to unannotated sequences in GenBank (1626). In addition to Atlantic halibut features, several control features have been incorporated, including an oligonucleotide representing a heterologous plant gene (92 spots) and empty spots containing buffer only (1344). The array contains 48 subgrids, each comprised of 32 columns and 26 rows. Every feature is printed at least four times as side‐by‐side quadruplicates, resulting in a microarray containing 39 936 features. This microarray has been utilized to identify genes differentially expressed in larval Atlantic halibut during the developmental period from post‐hatch to post‐metamorphosis. Early in development, transcription of the gene for hatching enzyme was down‐regulated, whereas a gene involved in eye development was up‐regulated. Midway to metamorphosis, transcription of genes encoding several key digestive enzymes was up‐regulated, and in pre‐metamorphic larvae, transcription of genes encoding muscle proteins was prominent.
Vision characteristics of individuals identified as Irlen Filter candidates. (1990)

Individuals with "scotopic sensitivity syndrome" have been reported to have visual symptoms including eye strain, headaches, blurred vision, double vision and words moving on the page. This study was designed to investigate Irlen's claims that these symptoms are unrelated to vision anomalies. She suggests that the use of Irlen tinted lenses/filters relieves these symptoms and results in improved reading performance. Thirty nine subjects (age 10-49) were recruited by advertising for a study of Irlen Filters/Lenses. Before the Irlen screening all subjects received an optometric examination. The results of this study demonstrate that 95 percent of the subjects identified as candidates for Irlen Filters did have significant and readily identifiable vision anomalies. Fifty seven percent of the subjects had received vision care within the past year, yet testing revealed that 90 percent of these subjects had significant vision problems that had not been corrected.
Mass Spectrometric Quantitation of Apurinic/Apyrimidinic Sites in Tissue DNA of Rats Exposed to Tobacco-Specific Nitrosamines and in Lung and Leukocyte DNA of Cigarette Smokers and Nonsmokers (2020)

Metabolic activation of the carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and <i>N</i>'-nitrosonornicotine (NNN) results in formation of reactive electrophiles that modify DNA to produce a variety of products including methyl, 4-(3-pyridyl)-4-oxobutyl (POB)-, and 4-(3-pyridyl)-4-hydroxybutyl adducts. Among these are adducts such as 7-POB-deoxyguanosine (N<sup>7</sup>POBdG) which can lead to apurinic/apyrimidinic (AP) sites by facile hydrolysis of the base-deoxyribonucleoside bond. In this study, we used a recently developed highly sensitive mass spectrometric method to quantitate AP sites by derivatization with <i>O</i>-(pyridin-3-yl-methyl)hydroxylamine (PMOA) (detection limit, 2 AP sites per 10<sup>8</sup> nucleotides). AP sites were quantified in DNA isolated from tissues of rats treated with NNN and NNK and from human lung tissue and leukocytes of cigarette smokers and nonsmokers. Rats treated with 5 or 21 mg/kg bw NNK for 4 days by s.c. injection had 2-6 and 2-17 times more AP sites than controls in liver and lung DNA (<i>p</i> < 0.05). Increases in AP sites were also found in liver DNA of rats exposed for 10 and 30 weeks (<i>p</i> < 0.05) but not for 50 and 70 weeks to 5 ppm of NNK in their drinking water. Levels of N<sup>7</sup>POBG were significantly correlated with AP sites in rats treated with NNK. In rats treated with 14 ppm (<i>S</i>)-NNN in their drinking water for 10 weeks, increased AP site formation compared to controls was observed in oral and nasal respiratory mucosa DNA (<i>p</i> < 0.05). No significant increase in AP sites was found in human lung and leukocyte DNA of cigarette smokers compared to nonsmokers, although AP sites in leukocyte DNA were significantly correlated with urinary levels of the NNK metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL). This is the first study to use mass spectrometry based methods to examine AP site formation by carcinogenic tobacco-specific nitrosamines in laboratory animals and to evaluate AP sites in DNA of smokers and nonsmokers.
Effect of heat sink design on thermoelectric cooling performance (1994)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Michael J. Nagy, Richard J. Buist; Effect of heat sink design on thermoelectric cooling performance. AIP Conf. Proc. 10 August 1994; 316 (1): 147–149. https://doi.org/10.1063/1.46781 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
IEEE Reliability Society Technical Operations Annual Technical Report for 2010 (2010)

The Annual Technical Report this year is focused on infrastructure reliability. Infrastructure constitutes those things that are apparent only in their absence. We take the infrastructure for granted, assuming it will always be there. We turn on our water facet, and drinkable water has always flowed out, for most of us, most of the time. Our infrastructure is subject to environment breakages (e.g., earthquakes), accidents (e.g., dig ups of cables), sabotage, intrusion, and compromise. Also everyday component, software or system failures can bring our infrastructure down. Our global connectivity and communications, as well as our world wide distributed development and maintenance systems, increase our productivity and efficiency, but can also increase our vulnerabilities. Our critical infrastructures can be found in many places.
Big data in daily manufacturing operations (2014)

Big data analytics is at the brink of changing the landscape in NXP Semiconductors Back End manufacturing operations. Numerous IT tools, implemented over the last decade, collect gigabytes of data daily, though the potential value of this data still remains to be explored. In this paper, the software tool called Heads Up is presented. Heads Up intelligently scans, filters, and explores the data with use of simulation. The software provides real-time relevant information, which is of high value in daily, as well as long term, production management. The software tool has been introduced at the NXP high volume manufacturing plant GuangDong China, where it is about to shift the paradigm on manufacturing operations.
Direct observation of electron relaxation in intrinsic GaAs using femtosecond pump-probe spectroscopy (1995)

The evolution of a nonequilibrium photoinjected electron population is investigated independently of the hole population using femtosecond pump-probe transmission in an unconventional configuration with the absorption saturation measured from the unoccupied spin-orbit-split valence band. Ultrafast electron relaxation is observed: within 40 fs the excited electrons are redistributed down to the band gap even for densities as low as ${10}^{17}$ ${\mathrm{cm}}^{\mathrm{\ensuremath{-}}3}$. Thermalization of the electron distribution is achieved already 200 fs after the end of the pump pulse. The electron temperature can be obtained as a function of time and an absorption increase observed at long times is attributed to a Fermi-edge singularity.
Rothia dentocariosa sepsis in a pediatric renal transplant recipient having post‐transplant lymphoproliferative disorders (2006)

To the best of our knowledge, this is the first case of RD sepsis in a pediatric solid organ transplant recipient.
Waterfall counters and an application to architectural vulnerability factor estimation (2023)

Described herein are waterfall counters and an application to architectural vulnerability factor (AVF) estimation. Waterfall counters count events that are generated at event generation logic. The waterfall counters are a combination of small, fast counters local to the event generation logic, and larger, global counters in fast memory. The local counters can be saturation or oscillation counters. When a local counter is saturated or evicted, the value from the local counter is added to the global counter. This addition can be done using logic local to the local or global counter. The waterfall counters provide a full-accuracy event count without the high bandwidth that is needed to maintain the global counters. An AVF estimation can be determined based on ratios from counts of read events, write events, and total events using the waterfall counters.
Simultaneously Learning Robust Audio Embeddings and balanced Hash codes for Query-by-Example (2022)

Audio fingerprinting systems must efficiently and robustly identify query snippets in an extensive database. To this end, state-of-the-art systems use deep learning to generate compact audio fingerprints. These systems deploy indexing methods, which quantize fingerprints to hash codes in an unsupervised manner to expedite the search. However, these methods generate imbalanced hash codes, leading to their suboptimal performance. Therefore, we propose a self-supervised learning framework to compute fingerprints and balanced hash codes in an end-to-end manner to achieve both fast and accurate retrieval performance. We model hash codes as a balanced clustering process, which we regard as an instance of the optimal transport problem. Experimental results indicate that the proposed approach improves retrieval efficiency while preserving high accuracy, particularly at high distortion levels, compared to the competing methods. Moreover, our system is efficient and scalable in computational load and memory storage.
Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender (2015)

Oxidative stress (OS) plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP) levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4) had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.
Electron Energy-Loss Spectroscopy and Energy-Filtered TEM Imaging for the in situ Assessment of Reduction-Oxidation Reactions in Ni-Based Solid Oxide Fuel Cells (2016)

parameters for improved performance and redox tolerance
Factors Predictive of Second Recurrence in Clubfeet Treated by Ponseti Casting (2014)

Level II-prognostic.