gebhart/patrepeval huggingface dataset:
The Tag Filter Cache: An Energy-Efficient Approach (2015)

Power consumption in current high-performance chip multiprocessors (CMPs) has become a major design concern. The current trend of increasing the core count aggravates this problem. On-chip caches consume a significant fraction of the total power budget. Most of the proposed techniques to reduce the energy consumption of these memory structures are at the cost of performance, which may become unacceptable for high-performance CMPs. On-chip caches in multi-core systems are usually deployed with a high associativity degree in order to enhance performance. Even first-level caches are currently implemented with eight ways. The concurrent access to all the ways in the cache set is costly in terms of energy. In this paper we propose an energy-efficient cache design, namely the Tag Filter Cache (TF-Cache) architecture, that filters some of the set ways during cache accesses, allowing to access only a subset of them without hurting the performance. Our cache for each way stores the lowest order tag bits in an auxiliary bit array and these bits are used to filter the ways that do not match those bits in the searched block tag. Experimental results show that, on average, the TF-Cache architecture reduces the dynamic power consumption up to 74.9% and 85.9% when applied to the L1 and L2 cache, respectively, for the studied applications.
Human papillomavirus detection in cervical lesions nondiagnostic for cervical intraepithelial neoplasia: correlation with Papanicolaou smear, colposcopy, and occurrence of cervical intraepithelial neoplasia. (1990)

Human papillomavirus (HPV) is associated with cervical intraepithelial neoplasia (CIN) and carcinomas. The present study involved women who had an abnormal Papanicolaou smear and whose cervix contained acetowhite area(s) that lacked the histologic features of CIN. Sequences homologous to HPV DNA, determined by Southern blot hybridization analysis, were detected in 20 of 59 cervical biopsy specimens (34%) that lacked the histologic features of CIN. When compared with the group in which HPV DNA was not detected, the HPV DNA-positive group had a lower chance of having a normal Papanicolaou smear (30 versus 61%) at the time of the biopsy. There was no difference in the colposcopic findings between the HPV DNA-positive and -negative cases for the biopsy specimens that lacked the features of CIN. However, there was a difference in the rate of histologically proved CIN in the two groups. Twelve of 17 women (71%) in the HPV DNA-positive group for whom there was follow-up information had a biopsy-proved CIN lesion noted at another location in the cervix at the time of biopsy (six) or 3-12 months after the biopsy (six). This rate was significantly higher (P less than .05) than the rate (five of 25, 20%) in the HPV DNA-negative cases, most of whom had no colposcopic abnormalities and a normal Papanicolaou smear at the follow-up examination. These findings indicate that HPV DNA detection in women with cervical lesions that lack the histologic features of CIN predicts current or future CIN in such patients.
Neurosarcoidosis Presenting in the Pituitary Gland with Normal Endocrine Studies (1999)

Two cases of neurosarcoidosis in the pituitary gland are presented with a review of past cases from the literature. Previous reported cases have always shown changes on the ondocrine exis clinically. These two cases, however, were endocrinologically normal prior to surgery. The evaluation of neurosarcoid in the pituitary, clinically and radiographically, is discussed.
Automated Design Method for Sine Wave Filters in Motor Drive Applications with SiC-Inverters (2020)

This work describes a design method for sine filters used for servo motor drive applications with a two level voltage source inverters (VSI) with 1200V SiC MOSFETs. To assess the filter effectiveness in attenuating conducted EMI emissions a worst case distortion spectrum of a PWM modulated half bridge midpoint voltage is calculated. The filter and the drive system are transformed to single phase differential (DM) and common mode (CM) equivalent circuits (EQC). The implemented algorithm enables parameter studies with various filter topologies, drive systems and values of filter components. The result of an example parameter study is analyzed and a suitable filter is built up and measured. The measured filter is then compared to the design results and the deviations are discussed.
Looking at the future of transdisciplinary research (2023)

Tackling complex issues that impact society requires scientific input and knowledge from academic experts and non-academic actors in order to find solutions. This paper looks at how science has become transdisciplinary, what is meant by transdisciplinarity and what we need to take into consideration
Microstructural Evolution in a Commercial Al-Mg-Sc Alloy during ECAP at 300°C (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Using Cognitive Task Analysis to Define Human Interface Requirements for First-of-A-Kind Systems (1995)

Cognitive task analysis (CTA) methods have grown out of the need to explicitly consider cognitive processing requirements of complex tasks. A number of approaches to CTA have been developed that vary in goals, the tools they bring to bear, and their data requirements. We present a particular CTA technique that we are utilizing in the design of new person-machine interfaces for first-of-a-kind advanced process control plants. The methodology has its roots in the formal analytic goal-means decomposition method pioneered by Rasmussen (1986). It contrasts with other approaches in that it is intended: (1) for design of first-of-a-kind systems for which there are no close existing analogues, precluding the use of CTA techniques that rely on empirical analysis of expert performance; (2) to define person-machine interface requirements to support operator problem-solving and decision-making in unanticipated situations; and (3) to be a pragmatic, codified, tool that can be used reliably by person-machine interface designers.
Model‐based measurements of the diameter of the internal carotid artery in CT angiography images (2010)

The authors have shown that the inclusion of a priori information results in accurate and precise diameter measurements of arteries with a small diameter. Furthermore, in patient data, the assumption of a circular cross-section often appears to be too simple. The extension to noncircular cross-sections and adjacent calcifications paves the way to realistic modeling of the carotid artery.
Electrically Detected Magnetic Resonance Studies of Processing Variations in 4H SiC Based MOSFETs (2008)

We apply electrically detected magnetic resonance (EDMR) to variously processed 4H SiC MOSFETs from two vendors. Although, the EDMR line shapes observed are nearly the same for vendor 1 devices subjected to a nitric oxide (NO) anneal and devices without it, the relationship between EDMR and gate voltage differs greatly between these samples. Furthermore, the EDMR response versus gate bias varies dramatically. EDMR results from a third device produced by a second vendor are very different from those provided by the first vendor. This result implies that significantly different defect populations are present in devices fabricated by different vendors.
Pose estimation from visual measurements using the epipolar constraint (2010)

This paper presents a new approach for estimating the pose, or position and orientation, of a target object relative to a camera. The approach assumes that the object geometry is known and that identifiable feature points on the object are tracked. Using the epipolar constraint, the problems of estimating orientation and position are decoupled. The orientation estimation problem is formulated and conditions under which the problem is well-posed are derived. An iterative numerical technique for solving the orientation estimation problem is presented, and the method is demonstrated in numerical simulations. A similar approach for simultaneously estimating position and orientation is also presented.
High-Quality Optical Frequency Comb by Spectral Slicing of Spectra Broadened by SPM (2013)

This paper introduces a spectral slicing technique that extends the useful spectral range of frequency combs generated through self-phase modulation (SPM) of mode-locked laser pulses. When generating frequency combs by SPM, the spectral range with high-quality carriers is usually limited due to spectral minima carrying too little power. To overcome these limitations, we combine suitable slices of broadened and nonbroadened spectra. The concept was experimentally verified: A total number of 325 consecutive equidistant subcarriers span a bandwidth of 4 THz. All subcarriers have an optical carrier-power-to-noise-power-density ratio (OCNR) larger than 25.8 dB (0.1 nm) and were derived from one mode-locked laser with a mode linewidth of approximately 1 kHz. The signal quality of the comb and in particular of each subcarrier was ultimately tested in a terabit-per-second communication experiment. The comb quality allowed us to transmit 32.5 Tb/s over 225 km with 100 Gb/s dual polarization 16-ary quadrature amplitude modulation (16QAM) signals on each of the subcarriers.
Tunicamycin-induced degeneration in cone photoreceptors (1988)

Tunicamycin (TM), an inhibitor of dolichylphosphate-mediated protein glycosylation, was injected intravitreally into the eyes of diurnal rodents with cone-dominated retinas. Injection of 1 microgram of the B2 isomer led to a progressive degeneration of the photoreceptor outer segments and disruption of the RPE-photoreceptor interface that took place over a 10-day period. Cone outer segments were shortened by postinjection day 6 and virtually absent by day 9. The microvilli that normally protrude from the apical surface of the retinal pigment epithelium were replaced by a fringe of shortened processes. The other retinal layers showed no morphological evidence of disruption. Retinal sensitivity, as measured by electroretinographic b-wave threshold, showed a significant and progressive decline over the 10-day course of the experiment that paralleled the disruption of retinal morphology. These results suggest that TM leads to similar morphological and electrophysiological effects on rod and cone photoreceptors.
An empirical evaluation of three popular training programs to improve interpersonal skills (2010)

Abstract As part of their talent development efforts, organizations implement training and development programs that often include some form of interpersonal or behavioral assessment. The study examined in this article compares three popular interpersonal skills training programs for measuring and understanding one's interpersonal style: Inscape's DiSC model, TRACOM Group's Social Style Model, and Consulting Psychologist Press's Myers‐Briggs Type Indicator. The facilitators found that participants in each program held positive reactions to training; participants in the Social Style training scored significantly higher than did participants in the DiSC and MBTI programs on a learning measure; and participants in the Social Style training scored significantly higher than did participants in the DiSC and MBTI programs on two measures of participants' skill at analyzing and responding to the interpersonal behaviors of others.
Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function (2023)

Missense variant Ile79Asn in human cardiac troponin T (cTnT-I79N) has been associated with hypertrophic cardiomyopathy and sudden cardiac arrest in juveniles. cTnT-I79N is located in the cTnT N-terminal (TnT1) loop region and is known for its pathological and prognostic relevance. A recent structural study revealed that I79 is part of a hydrophobic interface between the TnT1 loop and actin, which stabilizes the relaxed (OFF) state of the cardiac thin filament. Given the importance of understanding the role of TnT1 loop region in Ca<sup>2+</sup> regulation of the cardiac thin filament along with the underlying mechanisms of cTnT-I79N-linked pathogenesis, we investigated the effects of cTnT-I79N on cardiac myofilament function. Transgenic I79N (Tg-I79N) muscle bundles displayed increased myofilament Ca<sup>2+</sup> sensitivity, smaller myofilament lattice spacing, and slower crossbridge kinetics. These findings can be attributed to destabilization of the cardiac thin filament's relaxed state resulting in an increased number of crossbridges during Ca<sup>2+</sup> activation. Additionally, in the low Ca<sup>2+</sup>-relaxed state (pCa8), we showed that more myosin heads are in the disordered-relaxed state (DRX) that are more likely to interact with actin in cTnT-I79N muscle bundles. Dysregulation of the myosin super-relaxed state (SRX) and the SRX/DRX equilibrium in cTnT-I79N muscle bundles likely result in increased mobility of myosin heads at pCa8, enhanced actomyosin interactions as evidenced by increased active force at low Ca<sup>2+</sup>, and increased sinusoidal stiffness. These findings point to a mechanism whereby cTnT-I79N weakens the interaction of the TnT1 loop with the actin filament, which in turn destabilizes the relaxed state of the cardiac thin filament.
Wavelength conversion using polarization rotation in a bulk semiconductor optical amplifier (2006)

The aim of this investigation is to perform wavelength conversion using the nonlinear polarization rotation (NPR) effect and to develop a more detailed understanding of this technique so that the optimum system can be developed. The experiment is a pump-probe setup where the data carried on the pump is transferred to the continuous-wave (CW) probe by means of the NPR effect.
Evaluation biologique du stress oxydant : application en routine clinique. (2009)

peer reviewed
Synthesis, Structure, and Complex Magnetism of MIr<sub>2</sub>In<sub>8</sub> (M = Eu, Sr) (2016)

We report the synthesis, crystal structure, and physical properties of two new polar intermetallic compounds, EuIr2In8 and SrIr2In8. Both were synthesized in good yield using In metal as a reactive flux medium, enabling the growth of large crystals for physical property measurements. They crystallize in the orthorhombic space group Pbam with the CeFe2Al8 structure type, which is sometimes also referred to as the CaCo2Al8 structure type. The two analogues have unit cell parameters of a = 13.847(3) Å, b = 16.118(3) Å, and c = 4.3885(9) Å for M = Eu and a = 13.847(3) Å, b = 16.113(3) Å, and c = 4.3962(9) Å for M = Sr at room temperature. SrIr2In8 is a diamagnetic metal with no local magnetic moments on either the Sr or Ir sites, and the diamagnetic contribution from core electrons overwhelms the expected Pauli paramagnetism normally seen in intermetallic compounds. Magnetism in EuIr2In8 is dominated by the local Eu moments, which order antiferromagnetically at 5 K in low applied fields. Increasing the field strength depresses the magnetic ordering temperature and also induces a spin reorientation at lower temperature, indicating complex competing magnetic interactions. Low-temperature heat capacity measurements show a significant enhancement of the Sommerfeld coefficient in EuIr2In8 relative to that in SrIr2In8, with estimated values of γ = 118(3) and 18.0(2) mJ mol(-1) K(-2), respectively.
Konditionale Inaktivierung des FATP4-Gens in Enterozyten und Hepatozyten (2006)

Einleitung: Die physiologische Funktion von FATP4 (fatty acid transport protein 4) ist nach wie vor weitgehend ungeklärt. Das FATP4-Gen wird in vielen Geweben stark exprimiert, insbesondere auch in Dünndarm und Leber. Aus Untersuchungen an isolierten Enterozyten wurde eine essentielle Bedeutung von FATP4 für die Resorption von Fettsäuren im Dünndarm abgeleitet. Humangenetische Analysen deuten darauf hin, dass FATP4 ein Kandidatengen für das Insulinresistenzsyndrom ist. Von uns generierte Mäuse mit konstitutiver FATP4-Defizienz sterben kurz nach der Geburt; ihr Phänotyp gleicht dem Krankheitsbild der letalen restriktiven Dermopathie beim Menschen. Mit der Generierung einer Mauslinie mit epidermisspezifischer FATP4-Defizienz gelang es uns kürzlich, das FATP4-Gen in der Maus zelltypspezifisch zu inaktivieren.
Thermoluminescence of doped YAlO <sub>3</sub> crystals (2004)

The paper presents results of thermally stimulated luminescence (TSL) studies of YAlO3 crystals both pure and doped with rare-earth (Ho3+, Tm3+, Er3+) and Mn ions performed in the 20–600 K temperature range. The activation energy and frequency factor of traps have been determined. Nature of the traps and role of dopant ions are discussed.
Determination of arterial input function for quantification of cerebral blood flow with dynamic susceptibility contrast-enhanced MR imaging using fuzzy clustering (2002)

When quantifying the perfusion parameters such as cerebral blood flow (CBF) using dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC-MRI), the arterial input function (AIF) of contrast agent has to be determined. In this study, we developed a method for obtaining the AIF automatically using fuzzy c-means (FCM) clustering. First, a mask region of interest (ROI) was drawn around the internal carotid artery. Second, FCM clustering was applied to the data in this ROI and the cluster centroids were calculated. The cluster centroid with the highest maximum concentration, earliest maximum concentration and smallest FWHM of the time-concentration curve (TCC) was determined as the arterial pixels and the AIF was obtained from the mean TCC in these pixels. We applied this method to six subjects and compared it with a manual ROI method. The difference between the CBF values calculated using the AIF obtained by FCM clustering [CBF(fuzzy)] and that obtained by the manual ROI method [CBF(manual)] ranged from 0.92% to 122% [38.6/spl plusmn/37.7% (mean/spl plusmn/SD)]. The CBF(manual) values were generally overestimated compared with the CBF(fuzzy) values, while the CBF(fuzzy) values became closer to the CBF values found in the literature. In conclusion, FCM clustering appears to be promising for determination of AIF, because it allows automatic, rapid and accurate extraction of arterial pixels.
Development of a Superconducting Low-Noise 3.1-THz Hot Electron Bolometer Receiver (2015)

We have developed a hot electron bolometer mixer (HEBM) at 3.1 THz with a terahertz quantum cascade laser (THz- QCL) as a local oscillator. Both the HEBM and the THz-QCL device are fabricated in our laboratory. NbN film with 3 nm thickness was deposited on MgO substrate. The output power of the metal-metal waveguide type 3.1 THz-QCL was about 100 W at a heat sink temperature of 15 K. The lowest uncorrected receiver noise temperature of the HEBM was 1200 K (DSB). The corrected receiver noise temperature was 810 K (DSB). The measured IF noise bandwidth was about 3 GHz. The spectroscopic Allan time was 10 s. We have also demonstrated detection of emission line spectra of methanol [CH $_3$ OH ].
Atypical Pilocytic Astrocytoma in Adult: A Case Report (2011)

毛様細胞性星細胞腫は主に若年者に発生し,WHO分類でgrade Iに分類される比較的良性の腫瘍である.しかし成人発症の一部には予後不良な症例や非典型的な病理像を示す例があるとされ,同様の症例を報告する.症例は27歳女性.痙攣発作にて発症し,MRIのT2強調画像で左側頭葉上部に低信号のrimをもつ病変を認めた.摘出組織の病理所見は,密と粗な二相性の細胞密度と好酸性顆粒を示す毛様細胞性星細胞腫の特徴を示したが,一部に他の腫瘍を疑わせる所見を認め診断に苦慮した.IDH-1染色が診断に有用で,非典型的毛様細胞性星細胞腫と診断した.臨床像,画像所見,組織学的所見を含め報告する.
Extraction of the natural frequencies of a radar target from a measured response using E-pulse techniques (1987)

A new scheme is introduced for extracting the natural resonance frequencies of a radar target from a measured response. The method is based on the <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">E</tex> -pulse technique and is shown to be relatively insensitive to random noise and to estimates of modal content. Verification of the technique is accomplished by comparing the natural frequencies extracted from the measured responses of a thin cylinder and a circular loop with those obtained from theory. The applicability of the technique to low- <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</tex> targets is also demonstrated, using the measured response of a scale model aircraft.
Loss of Catalytically Inactive Lipid Phosphatase Myotubularin-related Protein 12 Impairs Myotubularin Stability and Promotes Centronuclear Myopathy in Zebrafish (2013)

X-linked myotubular myopathy (XLMTM) is a congenital disorder caused by mutations of the myotubularin gene, MTM1. Myotubularin belongs to a large family of conserved lipid phosphatases that include both catalytically active and inactive myotubularin-related proteins (i.e., "MTMRs"). Biochemically, catalytically inactive MTMRs have been shown to form heteroligomers with active members within the myotubularin family through protein-protein interactions. However, the pathophysiological significance of catalytically inactive MTMRs remains unknown in muscle. By in vitro as well as in vivo studies, we have identified that catalytically inactive myotubularin-related protein 12 (MTMR12) binds to myotubularin in skeletal muscle. Knockdown of the mtmr12 gene in zebrafish resulted in skeletal muscle defects and impaired motor function. Analysis of mtmr12 morphant fish showed pathological changes with central nucleation, disorganized Triads, myofiber hypotrophy and whorled membrane structures similar to those seen in X-linked myotubular myopathy. Biochemical studies showed that deficiency of MTMR12 results in reduced levels of myotubularin protein in zebrafish and mammalian C2C12 cells. Loss of myotubularin also resulted in reduction of MTMR12 protein in C2C12 cells, mice and humans. Moreover, XLMTM mutations within the myotubularin interaction domain disrupted binding to MTMR12 in cell culture. Analysis of human XLMTM patient myotubes showed that mutations that disrupt the interaction between myotubularin and MTMR12 proteins result in reduction of both myotubularin and MTMR12. These studies strongly support the concept that interactions between myotubularin and MTMR12 are required for the stability of their functional protein complex in normal skeletal muscles. This work highlights an important physiological function of catalytically inactive phosphatases in the pathophysiology of myotubular myopathy and suggests a novel therapeutic approach through identification of drugs that could stabilize the myotubularin-MTMR12 complex and hence ameliorate this disorder.