gebhart/patrepeval huggingface dataset:
Progression of type 1 diabetes from the prediabetic stage is controlled by interferon-α signaling (2017)

Blockade of IFN-α but not IFN-β signaling using either an antibody or a selective S1PR1 agonist, CYM-5442, prevented type 1 diabetes (T1D) in the mouse <i>Rip</i>-LCMV T1D model. First, treatment with antibody or CYM-5442 limited the migration of autoimmune "antiself" T cells to the external boundaries around the islets and prevented their entry into the islets so they could not be positioned to engage, kill, and thus remove insulin-producing β cells. Second, CYM-5442 induced an exhaustion signature in antiself T cells by up-regulating the negative immune regulator receptor genes <i>Pdcd1, Lag3, Ctla4, Tigit</i>, and <i>Btla</i>, thereby limiting their killing ability. By such means, insulin production was preserved and glucose regulation maintained, and a mechanism for S1PR1 immunomodulation described.
Détection de motifs temporels dans les environnements multi-perceptifs. Application à la classification automatique des Activités de la Vie Quotidienne d'une personne suivie à domicile par télémédecine (2008)

In the near 2050, about one third of the French population will be over 65. The works of the team AFIRM of the TIMC-IMAG focus on the monitoring of elderly people at home, to detect, as earlier as possible, a loss of autonomy. This thesis work aims at objectivising criterions as ADL or AGGIR grids by automatically classifying the different Activities of Daily Living performed by the subject during the day. A Health Smart Home is used to do this. <br />Our Smart Home includes, in a real flat, Presence Infra-Red Sensors, (for localisation), door contacts (for the use of some conveniences), temperature and hygrometry sensors in the bathroom and microphones (sound and speech recognition with the GETALP team of the LIG). The subject is also equipped with a kinematic sensor that delivers on the postural transition (by pattern recognition with wavelets) and walk periods (frequency analysis). <br />This manuscript is compound of two major parts. The first one introduces the realisation of the kinematic sensor, its algorithms and its first evaluation; but also the set-up, algorithms and the validation of the other sensors inside the flat and finally the Support Vector Machines algorithms to classify the activities of Daily Living (hygiene, toilets, preparing and having a meal, resting, sleeping, communication and dressing/undressing). The second part deals with the experimental protocol to validate these algorithms and the results of these validations on young and healthy subjects. It introduces the results and a discussion about their validity.
Laser two-photon ionization spectroscopy: a new method for real-time monitoring of atmospheric pollutants (1979)

Laser two-photon ionization spectroscopy is proposed as a selective and sensitive method of monitoring atmospheric pollutants in situ. The technique is demonstrated in the laboratory for a prototype molecule, aniline, in air at 1 atm. Advantages over existing laser-based methods are discussed, and an ultimate detection limit of <1 part in 10(11) is estimated using currently available technology.
Efficient terehertz generation with two pulse photoexcitation of metal microdroplet (2020)

We showed that focusing of two sequential subpicosecond laser pulses on the surface of microdroplet metallic target can lead to the efficient broadband pulsed THz generation. We observed the significant role of delay between pulses and their relative energies on conversion efficiency. We measured experimentally large angular diagram of the THz radiation.
A wavelet-domain algorithm for denoising in the presence of noise outliers (2002)

A wavelet domain robust denoising algorithm is presented, which efficiently removes both Gaussian as well as Gaussian mixed with impulse noise. Several wavelet domain operators are developed which help in the denoising process. The superiority of the new algorithm is firmly established by simulation over a variety of images.
Molecular Level Insights into the Structure of Active Sites of VAlO Mixed Oxides in Propane Ammoxidation (2013)

Several techniques such as 27Al 800-MHz NMR, X-ray diffraction (XRD; powder), X-ray photoelectron spectroscopy (XPS), electron paramagnetic resonance (EPR), Raman spectroscopy, and electrical conductivity measurements have been applied to characterize VAlO mixed oxides used in the selective ammoxidation of propane to acrylonitrile. The results confirmed that the catalysts were nitrided when exposed to ammoxidation conditions and that the nitridation occurred only for mixed oxides. The solids corresponding to poorly crystallized χ-alumina contained usual six-, five-, and four-coordinated aluminum and after testing, AlO3N species in significant amount. These results are in line with those of XPS showing besides adsorbed nitrogenous species, the presence of NH2– species allowing to propose AlO3(NH)VO5,6 as active site for catalytic nitridation. On another side, the samples prepared by a new method allowing to better disperse vanadium in the mixed oxide as shown by EPR, were shown to be more active and selective. Based on these observations, it is proposed that most selective sites for propane activation correspond to monomeric isolated species or to low-size oligomeric vanadium oxide species, which is in line with any other study of vanadium containing catalysts used for light alkanes oxidation or ammoxidation. Finally, nitrogen substitution in the bulk was shown to greatly enhance the electrical conductivity, which should facilitate the complete catalytic redox cycling.
Evolution of solutions to real-time problems (1997)

This thesis develops the theory and tools necessary for the determination of a near optimal Real-Time Operating System (RTOS) scheduling policy for an arbitrary multitasking problem specification. The solution is determined using a Genetic Algorithm (GA). All real-time operating systems provide some means of 'tuning' the characteristics of the scheduling policy to accurately meet the application requirements. This thesis shows the applicability of using a GA to determine these parameters for an arbitrary application. In addition, the RTOS parameters considered are broad enough to allow the results to be used for specifying and/or choosing an RTOS for the actual implementation of a real-time system. The domain of real-time applications which is of particular interest is that of embedded systems. In the embedded systems domain, real-time multitasking problems are specified by a series of timing constraints, time deadlines and practical available resources. These constraints guide the analysis of the results. A PC-based RTOS/GA tool set is the end result of this thesis and can be used for the analysis of arbitrary real-time applications.
Oocyte-Derived Factors (GDF9 and BMP15) and FSH Regulate AMH Expression Via Modulation of H3K27AC in Granulosa Cells (2018)

Anti-Müllerian hormone (AMH) produced by ovarian granulosa cells (GCs) plays a crucial role in ovarian function. It is used as a diagnostic and/or prognostic marker of fertility as well as for pathophysiological conditions in women. In this study, we investigated the underlying mechanism for regulation of AMH expression in GCs using primary mouse GCs and a human GC tumor-derived KGN cell line. We find that growth differentiation factor 9 (GDF9) and bone morphogenetic factor 15 (BMP15) together (GDF9 + BMP15), but not when tested separately, significantly induce AMH expression in vitro and in vivo (serum AMH). Our results show that GDF9 + BMP15 through the PI3K/Akt and Smad2/3 pathways synergistically recruit the coactivator p300 on the AMH promoter region that promotes acetylation of histone 3 lysine 27 (H3K27ac), facilitating AMH/Amh expression. Intriguingly, we also find that FSH inhibits GDF9 + BMP15-induced increase of AMH/Amh expression. This inhibition occurs through FSH-induced protein kinase A/SF1-mediated expression of gonadotropin inducible ovarian transcription factor 1, a transcriptional repressor, that recruits histone deacetylase 2 to deacetylate H3K27ac, resulting in the suppression of AMH/Amh expression. Furthermore, we report that ovarian Amh mRNA levels are significantly higher in Fshβ-null mice (Fshβ-/-) compared with those in wild-type (WT) mice. In addition, ovarian Amh mRNA levels are restored in Fshβ-null mice expressing a human WT FSHβ transgene (FSHβ-/-hFSHβWT). Our study provides a mechanistic insight into the regulation of AMH expression that has many implications in female reproduction/fertility.
Re: Impact of Sperm Cell Source on the Results of Intracytoplasmic Sperm Injection (2015)

No AccessJournal of UrologyAdult Urology1 May 2015Re: Impact of Sperm Cell Source on the Results of Intracytoplasmic Sperm Injection Craig NiederbergerMD Craig NiederbergerCraig Niederberger More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.02.031AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Re: Impact of Sperm Cell Source on the Results of Intracytoplasmic Sperm Injection." The Journal of Urology, 193(5), p. 1606 © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 193Issue 5May 2015Page: 1606Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.MetricsAuthor Information Craig Niederberger More articles by this author Expand All Advertisement PDF downloadLoading ...
Raman Spectroscopy as a Key Method to Distinguish the Ferroelectric Orthorhombic Phase in Thin ZrO<sub>2</sub>‐Based Films (2022)

Inducing and detecting the polar orthorhombic phase are crucial for the establishment of ferroelectricity in HfO 2 ‐ and ZrO 2 ‐based thin films. Unfortunately, commonly used structural characterization techniques such as grazing incidence angle X‐ray diffraction (GIXRD) only partially allow an accurate detection of this crystalline phase, whose characteristic pattern almost coincides with the one of the tetragonal phase. As a consequence, phase determination is commonly based on peak deconvolution tracing the position of the main peak at 2 θ values of around 30°, which can be assigned both to the t(101) and the o(111) plane directions and additionally be influenced by mechanical stress in the layers. Alternatively, epitaxial layers are required to differentiate the phase. Herein, using an integrated experimental–computational approach, it is shown how Raman spectroscopy can distinguish between the monoclinic, the tetragonal, and the orthorhombic phase of ZrO 2 . The Raman spectra calculated from first principles match the experimentally measured data and thus enable an unambiguous phase assignment. Therefore, Raman spectroscopy proves to be a powerful technique for discerning the three main crystalline phases in these materials. As demonstrated by the good agreement between structural and electrical data, it can therefore be used to predict ferroelectricity in the addressed layers.
Lung and Diaphragm Protection during Noninvasive Respiratory Support (2019)

n = 11).Two networks affirmed conducting studies that were unfunded or self-funded.Collaborations in critical care have expanded from activities largely conducted within research networks to include collaborations between research networks (Figure 2).Several key findings arise from our survey.First, research collaborations in critical care originated from a need for investigators to work together to advance the science behind caring for critically ill patients.Second, critical care collaborations largely focus on the design and implementation of randomized controlled trials.Third, most critical care research networks developed after 2005.Since this time, alliances have evolved in scope to include global collaborations between research networks.Fourth, most critical care research networks either conduct one or a few large studies or coordinate multiple research programs concurrently.Fifth, collaborative critical care research networks depend on peer-reviewed funding to cover infrastructure costs, with one-fourth of research networks being self-funded or unfunded.Sixth, financial support for studies is fragile and dependent on contributions from multiple funding partners.Collaborative research networks have transformed how critical care research has been conducted over the past three decades.The future critical care research agenda will be increasingly accountable to patient and family priorities and societal expectations for research investments to translate into better health care and outcomes (8).As the human and financial costs of research increase, we anticipate greater emphasis on strategies that will simplify the logistics and costs of conducting critical care research.Novel study designs and greater collaborations among research networks will be integral to advancing future research in critical care.
Increased Expression of Vascular Endothelial Growth Factor C in Papillary Thyroid Carcinoma Correlates with Cervical Lymph Node Metastases (2005)

Abstract Purpose: Despite recent studies showing that vascular endothelial growth factor C (VEGF-C) mRNA is up-regulated in papillary thyroid carcinoma (PTC), the role of VEGF-C in lymph node metastasis is still unclear. The aim of this study is to investigate the expression pattern of VEGF-C immunoreactive protein in PTC and its relationship with cervical lymph node metastasis. Experimental Design: Tissue samples were obtained from 39 specimens of PTC (20 with and 19 without lymph node metastasis) as well as 20 benign thyroid nodules. Overexpression of the VEGF-C protein was evaluated by immunoblotting with specific anti-VEGF-C antibody in paired tumor and nontumor tissues from PTC. The data were compared with patients' clinicopathologic features and lymph node metastasis. Immunohistochemical staining was done on selected paraffin sections to determine cellular localization of VEGF-C and to assess flt-4 (or VEGFR-3)–positive vessel density in PTC lesions. Results: Overexpression of VEGF-C was detected in 69% of the PTC and in 5% of the benign thyroid specimens. When comparing between the metastatic and nonmetastatic groups of PTC, a higher expression level of VEGF-C was detected in both the tumor (P = 0.004) and adjacent nontumor tissues (P = 0.011). Positive immunostaining for VEGF-C was confirmed in PTC tumor tissues and metastatic lymph nodes, which correlated with flt-4-positive vessel density in tumor and peritumor tissues. The increased expression of VEGF-C protein in PTC is associated with lymph node metastasis (P = 0.004) and lymphovascular permeation (P = 0.001) but is independent of other clinicopatholgic variables. Conclusions: The VEGF-C immunoreactive protein is overexpressed in PTC lesions, which correlates with lymph node metastases. VEGF-C expression may play a role in lymphangiogenesis of PTC and further study is necessary to evaluate the clinical application of VEGF-C as a molecular marker for tumor metastases to cervical lymph nodes.
Farm-level Interactions Study of a Novel Tri-port Soft-switching Medium-Voltage String Inverter (MVSI) based Large-scale PV-Plus-Storage Farms (2022)

A medium-voltage photovoltaic power conversion unit supported by battery based on a novel topology of soft switching solid state transformer is presented in this paper. It can reduce the Levelized Cost of Energy (LCOE) of PVS farm in an extended degree. However, its capability to provide grid-support services, such as frequency response, reactive power support, etc, have not been demonstrated. A series/parallel combination of these modules form a large 20 MVA solar farm. To validate them with reduced computation burden, a small-signal model of MVSI is firstly derived and validated in this paper. The model has been validated to match the full-switch model in both steady-state and dynamic conditions. Next, a farm-level simulation based on the proved small-signal model was implemented to demonstrate grid-support services. Real irradiation date from NREL is used to show the operational capabilities of the system. The overall farm is simulated based on MATLAB/Simulink domain to check the performance for various cases namely: power transfer from dc-ac side, reactive power support during grid voltage sag and utilization of battery during grid voltage disturbance or partial shading over PV panels.
Non-Enzymatic Phosphate Condensation in Dilute Aqueous Media-the Effect of Alkyl Substituents on Sulfamide (1990)

Abstract The reactions of alkyl-substituted sulfamides with diphosphate and triphosphate in dilute aqueous solution are examined to determine the reaction requirements with respect to the relative position of amino hydrogens. A nucleophilic attack by the sulfamide anion on the phosphate is postulated, resulting in the cyclocondensation of triphosphate to trimetaphosphate and the formation of amidophosphates. The major reaction pathway leads to the formation of sulfamate.
Towards a development environment to orchestrate services with certified security properties (2012)

Because of their nature and due to the technology on which they are currently based, service-oriented systems face important challenges related to security and trust. The lack of visibility of important information about service internals and about the operational environment in which they are operated, is hampering the adoption of a truly open service-oriented paradigm to realise applications composed of services coming from outside of the boundaries of a single organisation.
Parametric level-set approach for hyperspectral diffuse optical tomography (2011)

We explore the development and performance of algorithms for hyperspectral diffuse optical tomography (DOT) in which data from hundreds of wavelengths are collected and used to determine the concentration distribution of chromophores in the medium under investigation. An efficient method is detailed for forming the images using iterative algorithms applied to a linearized Born approximation model. Specifically, a parametric level-set approach is employed to obtain estimates of chromophore concentrations and scattering properties. We report image reconstructions using 126 wavelengths with mean square error around 0.05 for each chromophore in simulated data, a significant improvement over reconstructions using the level-set method and a pixel based method using fewer wavelengths chosen optimally according to the criterion in [1]. We additionally report improvement in reconstruction for phantom measurements where species concentrations are estimated more accurately than images constructed using fewer wavelengths.
Induction of directional sprouting angiogenesis by matrix gradients (2006)

The fate of any tissue engineering implant relies upon an adequate oxygen and nutrients supply throughout the cellular construct and, hence, by the ability of the scaffold to induce and guide vascular ingrowth. However, implant vascularization is usually an uncontrolled process that takes several weeks. In this work, we assessed the feasibility of controlling vascular sprout rate and direction within three-dimensional collagen-hyaluronic acid semi-interpenetrated networks by modulating the spatial distribution of the matricellular cues. Results indicated that increasing amount of hyaluronic acid (HA) within the matrix led to a progressive inhibition of sprouting. In HA-rich matrices, the sprout number and the propagation rate showed a 2.7- and 4-fold reduction, respectively, compared to collagen matrices. Furthermore, by creating HA gradients within the collagen network, we were able to direct and enhance the sprouting rate. This study provides an experimental platform for controlling vascularization of engineered tissues.
Driving simulation study: Bilateral Array multifocal versus bilateral AMO monofocal intraocular lenses (1999)

Differences between patients with bilateral multifocal IOLs and those with bilateral monofocal IOLs were detected; however, the results indicate no consistent difference in driving performance and safety.
Supplemental Table S2 from Clonal Hematopoiesis in Young Women Treated for Breast Cancer (2023)

&lt;p&gt;Genes Sequenced from Paired Baseline and Four-Year Blood Samples&lt;/p&gt;
Cysteamine supplementation during in vitro maturation and embryo culture: A useful tool for increasing the efficiency of bovine in vitro embryo production (2002)

Cysteamine when added during in vitro maturation (IVM) or in vitro embryo culture (IVC) stimulates glutathione (GSH) synthesis and improves embryo developmental rates. This suggests that GSH synthesis is decreased in the in vitro produced embryo. The present study was carried out to evaluate if addition of cysteamine to culture medium at the same time, during IVM and IVC of bovine oocytes, may promote an overall improvement on the developmental rate and embryo quality. Oocytes were matured in TCM 199 supplemented with 10% (v/v) fetal calf serum, hormones, and 0 or 100 microM of cysteamine for 24 hr. After IVM, the oocytes were fertilized (day 0). Day 2 embryos (2-8 cell) were washed and transferred to fresh IVC medium supplemented with 0, 25, 50, or 100 microM of cysteamine and cultured for 48 hr. After this, embryos were cultured in IVC medium without cysteamine until day 8 of IVC. In the present study, we confirmed our previous results by demonstrating that the percentage of embryos that developed to the blastocyst stage was significantly higher (P < 0.05) when 100 microM of cysteamine was added during IVM, and this was further improved when 100 and 50 microM of cysteamine where present during IVM and IVC, respectively (P < 0.05). After cryopreservation, no differences were observed on embryo development, but a significant increase on embryo hatching was found between unsupplemented and supplemented oocytes with 100 and 50 microM of cysteamine during IVM and IVC, respectively (P < 0.05). We can conclude that GSH synthesis stimulation during bovine IVM with cysteamine, concomitant with GSH stimulation during IVC, will be a useful and simple tool for increasing the efficiency of in vitro bovine embryo production.
Control on self-organization of InGaAs/GaAs(100) quantum-dot chains (2005)

The spontaneous formation of long chains of quantum dots during the growth of InGaAs/GaAs multiple layers has been reported recently. The effects of In content and spacer on the evolution of dotchains are investigated in the present work. By reducing the In content in the InGaAs layer, the quantum dots in chains are more connected and finally arrays of quantum wires would form. By changing the GaAs spacer layer thickness, the vertical and also lateral spacing between dotchains can be continually tuned. The capability to insert a thick layer of AlGaAs as part of the spacer layer enables us to fabricate InGaAs quantum-dot chains without vertical electronic coupling. The achieved control of self-assembly of organized InGaAs quantum dots may be advantageous for novel optoelectronic applications.
Empirical insights into the stochasticity of small RNA sequencing (2016)

The choice of stochasticity distribution for modeling the noise distribution is a fundamental assumption for the analysis of sequencing data and consequently is critical for the accurate assessment of biological heterogeneity and differential expression. The stochasticity of RNA sequencing has been assumed to follow Poisson distributions. We collected microRNA sequencing data and observed that its stochasticity is better approximated by gamma distributions, likely because of the stochastic nature of exponential PCR amplification. We validated our findings with two independent datasets, one for microRNA sequencing and another for RNA sequencing. Motivated by the gamma distributed stochasticity, we provided a simple method for the analysis of RNA sequencing data and showed its superiority to three existing methods for differential expression analysis using three data examples of technical replicate data and biological replicate data.