gebhart/patrepeval huggingface dataset:
Magnetic and Mössbauer Studies of Mn$_{0.679{-}{\rm x}}$Zn$_{0.256}$Ti$_{\rm x}$Fe$_{2.066}$O$_{4}$ Spinel Ferrites: Effect of Cation Distribution (2013)

MnZn ferrites substituted with titanium having the compositional formula of Mn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.679-x</sub> Zn <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">0.258</sub> Ti <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">x</sub> Fe <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2.066</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">4</sub> (x = 0, 0.010, 0.020, 0.030) were prepared via a conventional ceramic process. The effect of titanium concentration on magnetic properties such as permeability, power loss, and Curie temperature were investigated. Moreover, Mössbauer spectra was recorded at room temperature. The cation distribution obtained from analysis of Mössbauer spectra revealed that the substitution of MnZn ferrites by titanium can move part of Fe <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> from octahedral (B) site to tetrahedral (A) site. Remarkably, this resulted in an increase in the amount of Fe <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2+</sup> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">A</sub> -Fe <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3+</sup> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">B</sub> ion pairs and the Curie temperature. The results obtained and mechanisms involved are discussed.
528. Generation of a Cocal Envelope Packaging Cell Line for Robust Lentiviral Gene Transfer Into Hematopoietic Stem Cells and T Cells (2015)

Lentiviral vectors (LVs) are routinely used for stable gene transfer and have demonstrated great promise in clinical hematopoietic stem cell and immune cell gene therapy. LVs are commonly pseudotyped with vesicular stomatitis virus envelope glycoprotein (VSV-G), which confers broad tropism to the vector and allows for vector concentration by centrifugation. However, the use of VSV-G has several limitations, such as susceptibility to inactivation by human serum complement making it unsuitable for in vivo delivery, and toxicity when constitutively expressed, which has impeded efforts to generate stable producer cell lines. With the goal to generate a self-inactivating LV packaging cell line, we stably expressed either the VSV-G or cocal envelope in HEK293T cells along with other required helper genes, 3rd generation gagpol and rev. Genes were sequentially introduced in cells by co-transfection with plasmids containing an antibiotic resistance gene. After selection, best producer clones were isolated by limiting dilution and were treated with the histone deacetylase inhibitor sodium butyrate to enhance vector titer. The resulting cocal packaging cell line produces 20 to 50-fold more infectious particles as compared to VSV-G expressing cells, reaching titers averaging 108 infectious units/mL upon concentration. We also extend on our previous studies (Trobridge, 2010) by showing more robust gene transfer for cocal-pseudotyped LVs as compared to VSV-G pseudotyped LVs in human (81% cocal vs. 45% VSV-G, MOI 5) and non-human primate (Macaca nemestrina) CD34+ HSPCs (45% cocal vs. 18% VSV-G, MOI 2×5) while preserving similar differentiation potential as determined by CFC assays. Cocal vectors also transduced human CD3+ blood cells more efficiently than VSV-G vectors (65% cocal vs. 42% VSV-G vs., MOI 3) and showed comparable transduction efficiency in non-human primate CD3+ cells. Using a competitive repopulation approach in the non-human primate model, we find increased gene marking in repopulating cells transduced with a cocal pseudotyped LVs compared to repopulating cells transduced with the same lentivirus backbone pseudotyped with VSV-G. We observed a dramatic difference in the granulocyte fraction where marking with the cocal vector reaches ~90% at 70 days post transplantation. Retroviral integration site analysis is currently underway to characterize the integration profile of cocal vs. VSV-G modified clones. Overall, our study suggests that the cocal envelope outperforms the VSV-G envelope in a stable lentivirus packaging cell line, which may prove useful in current gene therapy efforts to generate large-scale clinical grade vectors.
Size Reduction of a Quasi Class-E High Power Amplifier Using Defected Ground Structure (2010)

본 논문에서는 접지 결함 구조(Defected Ground Structure: DGS)를 이용하여 기지국용 고효율 E급 전력 증폭기의 성능을 유지하면서 크기를 소형화 할 수 있는 방안을 제안하였다. E급 전력 증폭기에서 요구되는 고조파 임피던스는 아령형 DGS와 나선형 DGS를 사용함으로써 만족시켜 주었다. 제안하는 유사 E급 전력 증폭기의 DGS 부하 회로는 가장 큰 고조파 성분인 2차 고조파 대역에서 개방, 나머지 고차 고조파 임피던스는 단락에 가까운 고조파 임피던스를 갖는다. 제안하는 구조를 통하여 제작된 전력 증폭기는 출력 전력이 43.1 dBm, 포화전력 이득이 12.7 dB일 때 70.2 %의 전력 부가 효율(Power Added Efficiency: PAE)을 가지며, 이는 비교 대상인 E급 증폭기와 거의 유사한 값이다. 회로 크기의 관점에서 보면 각각의 고조파 성분 정합을 위해 여러 개의 스터브가 장착되어 있는 비교 대상인 E급 증폭기에 비해 전체 크기를 50 %로 소형화시킬 수 있었다. In this work, a reduced size 20W quasi class-E Power Amplifier(PA) with defected ground structure load-network is presented for WCDMA base station application. Harmonic impedances required for the class E operation are satisfied by applying the dumbbell and the asymmetric spiral DGS. Open impedance for 2nd harmonic frequency which has the highest power and nearly short impedances for other higher order harmonics are provided by the proposed DGS load-network. The maximum Power Added Efficiency(PAE) of 70.2 % at the output power of 43.1 dBm with the saturated power gain of 12.7 dB is achieved by the proposed quasi class-E PA, which is comparable to the performance of the reference class-E PA. Total size of the proposed class-E PA is only <TEX>$50{\times}50\;mm^2$</TEX> and much smaller than the conventional class-E PA that is loaded with a number of open stubs.
A high performance broadcast design with hardware multicast and GPUDirect RDMA for streaming applications on Infiniband clusters (2014)

Several streaming applications in the field of high performance computing are obtaining significant speedups in execution time by leveraging the raw compute power offered by modern GPGPUs. This raw compute power, coupled with the high network throughput offered by high performance interconnects such as InfiniBand (IB) are allowing streaming applications to scale to rapidly. A frequently used operation that constitutes to the execution of multi-node streaming applications is the broadcast operation where data from a single source is transmitted to multiple sinks, typically from a live data site. Although high performance networks like IB offer novel features like hardware based multicast to speed up the performance of the broadcast operation, their benefits have been limited to host based applications due to the inability of IB Host Channel Adapters (HCAs) to directly access the memory of the GPGPUs. This poses a significant performance bottleneck to high performance streaming applications that rely heavily on broadcast operations from GPU memories. The recently introduced GPUDirect RDMA feature alleviates this bottleneck by enabling IB HCAs to perform data transfers directly to / from GPU memory (bypassing host memory). Thus, it presents an attractive alternative to designing high performance broadcast operations for GPGPU based high performance streaming applications. In this work, we propose a novel method for fully utilizing GPUDirect RDMA and hardware multicast features in tandem to design a high performance broadcast operation for streaming applications. The experiments conducted with the proposed design show up 60% decrease in latency and 3X-4X improvement in a throughput benchmark compared to the naive scheme on 64 GPU nodes.
Simulation of a compact analyzer-based imaging system with a regular x-ray source (2017)

Analyzer-based Imaging (ABI) belongs to a broader family of phase-contrast (PC) X-ray techniques. PC measures X-ray deflection phenomena when interacting with a sample, which is known to provide higher contrast images of soft tissue than other X-ray methods. This is of high interest in the medical field, in particular for mammogram applications. This paper presents a simulation tool for table-top ABI systems using a conventional polychromatic X-ray source.
Identification of “Preferred” Human Kinase Inhibitors for Sleeping Sickness Lead Discovery. Are Some Kinases Better than Others for Inhibitor Repurposing? (2016)

A kinase-targeting cell-based high-throughput screen (HTS) against <i>Trypanosoma brucei</i> was recently reported, and this screening set included the Published Kinase Inhibitor Set (PKIS). From the PKIS was identified 53 compounds with pEC<sub>50</sub> ≥ 6. Utilizing the published data available for the PKIS, a statistical analysis of these active antiparasitic compounds was performed, allowing identification of a set of human kinases having inhibitors that show a high likelihood for blocking <i>T. brucei</i> cellular proliferation in vitro. This observation was confirmed by testing other established inhibitors of these human kinases and by mining past screening campaigns at GlaxoSmithKline. Overall, although the parasite targets of action are not known, inhibitors of this set of human kinases displayed an enhanced hit rate relative to a random kinase-targeting HTS campaign, suggesting that repurposing efforts should focus primarily on inhibitors of these specific human kinases. We therefore term this statistical analysis-driven approach "<i>preferred lead repurposing</i>".
Observable clock synchronization extended abstract (1994)

While the synchronization of time-o!-day clocks ordinarily requires information f70w in both directions between the clocks, this information need not j70w directlp via messages. However, to take advantage of in-
Acoustic monitoring of radial water drilling progress (2018)

The radial water jet drilling technology is used to increase the inflow into insufficiently producing geothermal wells. During radial water jet drilling, laterals are jetted into a target formation using an existing well. A focused water jet is applied to the rock through a nozzle attached to a coiled tubing. The method is applied to access and connect high permeability zones within geothermal reservoirs. However, the geometry of the jetted path is not measured during default applications. Techniques for determining the geometry of radial paths can be adopted from equivalent applications in the oil and gas industry, where we can distinguish between direct measurements with tools being fixed to the drill bit, and indirect measurements where sensors are remotely installed. Such sensors record the acoustic emission field, which is inverted towards drill bit position as a function of time. During radial water jet drilling, a continuous source signal is induced. In this study we will explore the potential of inverting the acoustic wavefield generated by the nozzle, towards a nozzle source location as a function of time. We specifically focus on inverting the continuous signal to a location of the nozzle using a method analogue to drill-bit interferometry. We use experimental data acquired in a quarry in Gildehaus (Germany) with a set-up mimicking a downhole application where sensors are placed vertically along the well. Here several jetting tests were conducted, while acoustic data was acquired with seismic accelerometers and piezo-elements. We consider the acoustic signatures of data acquired during jetting tests and address the localization outcomes of the accelerometer and piezo-element data, as compared to in-situ geometry measurement.
Platelet activating factors are associated with depressive symptoms in coronary artery disease patients: a hypothesis-generating study (2015)

Introduction: Depression is a frequent complication of coronary artery disease (CAD) with an unknown etiology. Platelet activating factor (PAF) lipids, which are associated with CAD, have recently been linked with novel proposed etiopathological mechanisms for depression such as inflammation, oxidative/nitrosative stress, and vascular endothelial dysfunction. Methods and results: This hypothesis-generating study investigated the relationships between various PAF species and depressive symptoms in 26 CAD patients (age: 60.6±9.2 years, 69% male, mean Hamilton Depression Rating Scale [HAM-D] score: 11.8±5.2, HAM-D range: 3–20). Plasma PAF analyses were performed using high performance liquid chromatography electrospray ionization mass spectrometry in precursor ion scan. Significant associations between depressive symptom severity (HAM-D score) and a greater plasma abundance of the PAFs phosphocholine (PC) PC(O-12:0/2:0) ( r =0.49, P =0.01), PC(O-14:1/2:0) ( r =0.43, P =0.03), PC(O-17:3/2:0) ( r =0.44, P =0.04), and PC(O-18:3/2:0) ( r =0.50, P =0.01) were observed. Associations between those PAFs and HAM-D score persisted after adjusting for age and sex. Conclusion: These preliminary findings support the exploration of the PAF lipidome for depressive symptom biomarkers in CAD patients. Patients were recruited as part of the following clinical trial: NCT00981383. Keywords: depression, lipidomics, cardiovascular, inflammation, oxidative stress, biomarker, vascular depression
Suggestions for Reporting Solutions to End of Chapter Problems (2013)

Book DOI: 10.1049/SBPC501E Chapter DOI: 10.1049/SBPC501E_appendixa ISBN: 9781613531884 e-ISBN: 9781613530276
Biogeochemical and Environmental Factors in Fe Biomineralization: Magnetite and Siderite Formation (2003)

Abstract The formation of siderite and magnetite by Fe(III)-reducing bacteria may play an important role in C and Fe geochemistry in subsurface and ocean sediments. The objective of this study was to identify environmental factors that control the formation of siderite (FeCO 3 ) and magnetite (Fe 3 O 4 ) by Fe(III)-reducing bacteria. Psychrotolerant (&lt;20°C), mesophilic (20–35°C) and thermophilic (&gt;45°C) Fe(III)-reducing bacteria were used to examine the reduction of a poorly crystalline iron oxide, akaganeite (β-FeOOH), without a soluble electron shuttle, anthraquinone disulfuonate (AQDS), in the presence of N 2 , N 2 -CO 2 (80:20, V:V), H 2 and H 2 -CO 2 (80:20, V:V) headspace gases as well as in -buffered medium (30–210 mM) under a N 2 atmosphere. Iron biomineralization was also examined under different growth conditions such as salinity, pH, incubation time, incubation temperature and electron donors. Magnetite formation was dominant under a N 2 and a H 2 atmosphere. Siderite formation was dominant under a H 2 -CO 2 atmosphere. A mixture of magnetite and siderite was formed in the presence of a N 2 -CO 2 headspace. Akaganeite was reduced and transformed to siderite and magnetite in a -buffered medium (&gt;120 mM) with lactate as an electron donor in the presence of a N 2 atmosphere. Biogeochemical and environmental factors controlling the phases of the secondary mineral suite include medium pH, salinity, electron donors, atmospheric composition and incubation time. These results indicate that microbial Fe(III) reduction may play an important role in Fe and C biogeochemistry as well as C sequestration in natural environments.
In situ ESEM Study of Liquid Transport through Carbon Nanopipes (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
A Psychological and Neuroanatomical Model of Obsessive-Compulsive Disorder (2008)

Imaging, surgical, and lesion studies suggest that the prefrontal cortex (orbitofrontal and anterior cingulate cortexes), basal ganglia, and thalamus are involved in the pathogenesis of obsessive-compulsive disorder (OCD). On the basis of these findings several models of OCD have been developed, but have had difficulty fully integrating the psychological and neuroanatomical findings of OCD. Recent research in the field of cognitive neuroscience on the normal function of these brain areas demonstrates the role of the orbitofrontal cortex in reward, the anterior cingulate cortex in error detection, the basal ganglia in affecting the threshold for activation of motor and behavioral programs, and the prefrontal cortex in storing memories of behavioral sequences (called "structured event complexes" or SECs). The authors propose that the initiation of these SECs can be accompanied by anxiety that is relieved with completion of the SEC, and that a deficit in this process could be responsible for many of the symptoms of OCD. Specifically, the anxiety can form the basis of an obsession, and a compulsion can be an attempt to receive relief from the anxiety by repeating parts of, or an entire, SEC. The authors discuss empiric support for, and specific experimental predictions of, this model. The authors believe that this model explains the specific symptoms, and integrates the psychology and neuroanatomy of OCD better than previous models.
Holistic analytical design of induction motors for automotive application (2014)

This paper deals with an algorithm to optimize the efficiency of induction motors used in electrified power trains of battery electric or hybrid vehicles. In this drivetrain concepts it is necessary to design electric drives of high efficiency in order to maximize driving range and performance. The algorithm is part of a holistic design process which is presented as well. It will be shown how efficiency maps are generated and created and in which way different control strategies influence the drive efficiency. Therefore efficiency analyses of two different induction machines with field oriented and rotor frequency control is presented and compared.
Glycosphingolipid synthesis inhibitor AMP.DNM lowers plasma cholesterol levels by promoting fecal cholesterol excretion without inhibiting cholesterol absorption (2012)

Inhibition of glycosphingolipid synthesis with iminosugar N-(5’L-adamantane-1’L-yl-methoxy)-pentyl-1-deoxynojirimycin (AMP.DNM) increases fecal neutral sterol output in mice. To investigate which pathways were involved in this increase, C57Bl/6J mice were treated with AMP.DNM and/or ezetimibe. Fecal neutral sterol output increased by threefold with combined AMP.DNM/ezetimibe treatment compared with approximately twofold increases with single treatments. Bile canulations and intestine perfusions showed that biliary cholesterol secretion and transintestinal cholesterol efflux were increased in mice receiving AMP.DNM treatment. This study indicates that AMP.DNM treatment of mice increases fecal neutral sterol by promoting biliary and intestinal cholesterol secretion without inhibiting cholesterol absorption.
Automated Grading System for Evaluation of Superficial Punctate Keratitis Associated With Dry Eye (2015)

An objective, automated analysis of corneal staining provides a quality assurance tool to be used to substantiate clinical grading of key corneal staining endpoints in multicentered clinical trials of dry eye.
Efficacy of endovascular treatment of meningiomas: evaluation with matched samples. (1994)

Endovascular devascularization of meningiomas is beneficial for large meningiomas because it diminishes the necessity of intraoperative transfusions and decreases blood loss. The additional day of hospitalization, emolization costs, and costs of complications do not conversely increase treatment costs. There were no major complications or adverse long-term effects caused by the embolization procedure.
ABCG2 Harboring the Gly482 Mutation Confers High-Level Resistance to Various Hydrophilic Antifolates (2005)

ABCG2 is an ATP-binding cassette transporter that confers resistance to various chemotherapeutic agents. Recent studies have established that an Arg (wild-type) to Gly mutation at amino acid 482 in ABCG2 alters substrate specificity. Here, we explored the role of this G482 mutation in antifolate resistance using a clinically relevant 4-hour drug exposure. Stable transfectants overexpressing the mutant G482 transporter displayed 120-, 1,000-, and >6,250-fold resistance to the antifolates methotrexate, GW1843, and Tomudex, respectively, relative to parental human embryonic kidney cells. Moreover, although overexpressing equal transporter levels at the plasma membrane, G482-ABCG2 cells were 6-, 23-, and >521-fold more resistant to methotrexate, GW1843, and Tomudex, respectively, than R482-ABCG2 cells. In contrast, upon a continuous (72-hour) drug exposure, both the G482- and R482-ABCG2 cells lost almost all their antifolate resistance; this result was consistent with the inability of ABCG2 to extrude long-chain antifolate polyglutamates. Ko143, a specific and potent ABCG2 inhibitor reversed methotrexate resistance in both G482- and R482-ABCG2 cells. Consistently, whereas the pool of free methotrexate in parental human embryonic kidney cells was prominent after 4 hours of transport with 1 micromol/L [3H]methotrexate, in R482- and G482-ABCG2 cells, it was minimal. Furthermore, G482-ABCG2 cells contained marked decreases in the di- and triglutamate species of [3H]methotrexate at 4 hours of incubation with methotrexate and in the tetra- and pentaglutamates at 24 hours. These changes were not associated with any significant decrease in folylypoly-gamma-glutamate synthetase activity. These results provide the first evidence that the G482-ABCG2 mutation confers high-level resistance to various hydrophilic antifolates.
Supplementary Figure S6 from Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast Cancer (2023)

&lt;p&gt;Supplementary Figure S6. Immunohistochemical stainings of ERRalpha in primary ERalpha-positive breast carcinomas on a tissue microarray (n=1041).&lt;/p&gt;
Collision energy analysis of miniature electromagnetic relay with permanent magnet (2012)

Recently, miniature electromagnetic relays are required to have high reliability. The reliability of the relay is lost by numerous collisions of a contact. Therefore, we calculate the collision energy of a miniature electromagnetic relay with a permanent magnet through the dynamic characteristics analysis using the three-dimensional finite element method (3-D FEM). The effects of the material of the armature and the number of coil turns on the collision energy are numerically clarified.
Uncovering Latent Style Factors for Expressive Speech Synthesis (2017)

Prosodic modeling is a core problem in speech synthesis. The key challenge is producing desirable prosody from textual input containing only phonetic information. In this preliminary study, we introduce the concept of "style tokens" in Tacotron, a recently proposed end-to-end neural speech synthesis model. Using style tokens, we aim to extract independent prosodic styles from training data. We show that without annotation data or an explicit supervision signal, our approach can automatically learn a variety of prosodic variations in a purely data-driven way. Importantly, each style token corresponds to a fixed style factor regardless of the given text sequence. As a result, we can control the prosodic style of synthetic speech in a somewhat predictable and globally consistent way.
Improved refractive outcomes of postgraduate year 4 cataract surgery after implementing a stepwise biometry lecture series reinforced by self-assessment at a teaching program (2016)

None of the authors has a financial or proprietary interest in any material or method mentioned.
&lt;p&gt;The safety, pharmacodynamics, and pharmacokinetics of immediate-release formulation containing esomeprazole 20 mg/sodium bicarbonate 800 mg in healthy adult male&lt;/p&gt; (2019)

This study showed that IR-ESO produced a rapid, safe and sustained gastric acid suppression (ClinicalTrials.gov: NCT03211143).