gebhart/patrepeval huggingface dataset:
Hybrid Simulation Environment for rapid MSP430 system design test and validation using MSPsim and SystemC (2011)

Modern, energy-efficient sensor nodes cover a wide variety of application scenarios. For a fast adapting of these devices to new requirements a concurrent development process of software and hardware extensions must be feasible. Here we present a Hybrid Simulation Environment (HSE) that combines a cycle accurate simulator for MSP microcontrollers written in Java and SystemC, which allows description of hardware at reasonable abstraction level. The HSE significantly speeds up the simulation of new components compared to conventional simulation engines.
Drak-State Microring Lasers: Using Exceptional Points for Mode Management (2015)

A semiconductor microring laser based on a dark state configuration is demonstrated. Single mode lasing is achieved by judiciously exploiting non-Hermitian exceptional points. © 2015 OSA.
PLD implementation of logic controllers (2002)

This paper presents a unified design environment of concurrent logic controllers, based on the use of Petri nets, rule-based description languages and PL4 specification languages (especially AMD Palasm 4). The straightforward templates are presented that made possible a rule-based Petri net specification to be simulated and then efficiently synthesised with modern programmable devices. Though the example presented in this paper is relatively trivial, the concepts are directly applicable in the more realistic designs.
How to Sign Paper Contracts? Conjectures & Evidence Related to Equitable & Efficient Collaborative Task Scheduling (2013)

International audience
Selective modification of the catalytic subunit of cAMP-dependent protein kinase with sulfhydryl-specific fluorescent probes (1989)

The catalytic subunit of cAMP-dependent protein kinase contains only two cysteine residues, and the side chains of both Cys 199 and Cys 343 are accessible. Modification of the catalytic subunit by a variety of sulfhydryl-specific reagents leads to the loss of enzymatic activity. The differential reactivity of the two sulfhydryl groups at pH 6.5 has been utilized to selectively modify each cysteine with the following fluorescent probes: 3,6,7-trimethyl-4-(bromomethyl)-1,5-diazabicyclo[3.3.0]octa-3,6-diene- 2,8-dione, N-(iodoacetyl)-N'-(5-sulfo-1-naphthyl)ethylenediamine, and 4-[N-[(iodoacetoxy)ethyl]-N-methyl-amino]-7-nitrobenz-2-oxa-1,3-diazole. The most reactive cysteine is Cys 199, and exclusive modification of this residue was achieved with each reagent at pH 6.5. Modification of Cys 343 required reversible blocking of Cys 199 with 5,5'-dithiobis(2-nitrobenzoic acid) followed by reaction of Cys 343 with the fluorescent probe at pH 8.3. Treatment of this modified catalytic subunit with reducing reagent restored catalytic activity by unblocking Cys 199. In contrast, catalytic subunit that was selectively labeled at Cys 199 by the fluorescent probes was catalytically inactive. Even though Cys 199 is presumably close to the interaction site between the regulatory subunit and the catalytic subunit, all of the modified C-subunits retained the capacity to aggregate with the type II regulatory subunit in the absence of cAMP, and the resulting holoenzymes were dissociated in the presence of cAMP.(ABSTRACT TRUNCATED AT 250 WORDS)
Effects of Molecular Weight Reduction on Brittle–Ductile Transition and Elastic Yielding Due to Noninvasive γ Irradiation on Polymer Glasses (2017)

By exposing specimens to the γ irradiation, we show that polymer glasses including bisphenol A polycarbonate (PC) and poly(methyl methacrylate) (PMMA) turn from ductile to brittle due to chain scission by the irradiation that has noninvasively reduced their molecular weight. More importantly, by causing chain scission with the γ irradiation, we examine the origin of mechanical stress produced from cold drawing of four ductile polymer glasses (PC, PMMA, polystyrene, and poly(2,6-dimethyl-1,4-phenylene oxide)). Specifically, we elucidate the origin of the residual stress embedded in the glassy state from the cold-drawing of these polymer glasses into the strain hardening regime by investigating the elastic yielding behavior of these cold-drawn specimens. In contrast to the emergent retractive stress observed during annealing of the cold-drawn specimens above their storage temperature but still well below their glass transition temperatures, we find significantly lower retractive stress level and longer induction time for the retractive stress to show up when these specimens undergo sufficient dosage of the γ irradiation whose effect on the molecular weight and its distribution has been measured with gel permeation chromatography.
Network-based analysis of reverse phase protein array data (2016)

In this paper, we introduce a computational method for constructing networks based on reverse phase protein array (RPPA) data to identify complex patterns in protein signaling. The method is applied to phosphoproteomic profiles of basal expression and activation/phosphorylation of 76 key signaling proteins in three breast cancer cell lines (MCF7, LCC1, and LCC9). Temporal RPPA data are acquired at 48h, 96h, and 144h after knocking down four genes in separate experiments. These genes are selected from a previous study as important determinants for breast cancer survival. Interaction networks between the proteins and phosphorylated proteins are constructed by analyzing the expression levels of protein pairs using a multivariate analysis of variance model. A new scoring criterion is introduced to determine the proteins that changed significantly at each of the three time points. Signaling networks are constructed based on statistically significant protein pairs selected from the RPPA data. Through a topology based analysis, we search for wiring patterns to help identify key network nodes that are associated with protein expression changes in various experimental conditions.
Interaction between PNPLA3 I148M Variant and Age at Infection in Determining Fibrosis Progression in Chronic Hepatitis C (2014)

We observed an interaction between homozygosity for the PNPLA3 I148M variant and age at infection in determining fibrosis progression in CHC patients.
Value locality and load value prediction (1996)

Since the introduction of virtual memory demand-paging and cache memories, computer systems have been exploiting spatial and temporal locality to reduce the average latency of a memory reference. In this paper, we introduce the notion of value locality, a third facet of locality that is frequently present in real-world programs, and describe how to effectively capture and exploit it in order to perform load value prediction. Temporal and spatial locality are attributes of storage locations, and describe the future likelihood of references to those locations or their close neighbors. In a similar vein, value locality describes the likelihood of the recurrence of a previously-seen value within a storage location. Modern processors already exploit value locality in a very restricted sense through the use of control speculation (i.e. branch prediction), which seeks to predict the future value of a single condition bit based on previously-seen values. Our work extends this to predict entire 32- and 64-bit register values based on previously-seen values. We find that, just as condition bits are fairly predictable on a per-static-branch basis, full register values being loaded from memory are frequently predictable as well. Furthermore, we show that simple microarchitectural enhancements to two modern microprocessor implementations (based on the PowerPC 620 and Alpha 21164) that enable load value prediction can effectively exploit value locality to collapse true dependencies, reduce average memory latency and bandwidth requirements, and provide measurable performance gains.
Influence of Income Amongst Members of the American Society of Plastic Surgeons (2012)

INTRODUCTION: Little has been written about the influence of income in plastic and reconstructive surgery (PRS), likely because the controversial nature of the subject. However, income may have important influences on career satisfaction, burnout and quality of life. Therefore, the purpose of this study was to evaluate the influence of income in PRS. METHODS: As part our National Burnout Survey of American Society of Plastic Surgery (ASPS) members conducted between September 2010 and 2011, we evaluated the influence of income. Surgeons were asked to report annual income and rank perceived stressors at work in addition to completing validated measures of burnout (Maslach Burnout Inventory), quality of life (SF-12 Health Survey), and answering a standardized questionnaire regarding career satisfaction (1). RESULTS: Of the 5,942 surgeons invited, 1,754 (29.5%) actively practicing ASPS members completed the survey. Income was reported to be the third (of 12) greatest stressor at work (58.2%), behind work-personal life balance (77.2%) and time demands (66.3%). There were significant association between burnout and income, with burnout being significantly greater in surgeon making less than $200,000 or greater than $500,000 per year (p<0.05 and p<0.01, respectively). Career satisfaction had a direct relationship with income up to $750,000 annual income (correlation co-efficient 0.79, p<0.01), above which career satisfaction significantly decreased (p<0.05). This mirrored the relationship between annual income and hours worked per week (p<0.01). There was no significant relationship between income and quality of life. CONCLUSION: There is a strong association between income, burnout and career satisfaction. Interestingly, it appears that surgeons are willing to accept some level burnout for an increase in annual income; however, there is no discernible relationship between income and quality of life.
Interacting With a Visiting Dog Increases Fingertip Temperature in Elderly Residents of Nursing Homes (2020)

The aim of this study was to investigate whether interacting with a visiting dog influences fingertip temperature and cortisol levels in residents living in nursing homes for the elderly. The study included two groups, the dog group (<i>n</i> = 13) and the control group (<i>n</i> = 11-15) and lasted for 8 weeks for the dog group and 6 weeks for the control group. All participants were residents living at nursing homes for the elderly. The researchers visited small groups of the participants twice weekly during the entire study in both the dog and the control group. The visiting dog and the dog handler accompanied the researchers during weeks 3-6. Fingertip temperature was measured and saliva samples for cortisol determination were collected at 0, 20 and 60 min for the dog group and at 0 and 20 min for the control group. For analysis the study was divided into periods; Period 1 (week 1-2), Period 2 (week 3-4), Period 3 (week 5-6) and Period 4 (week 7-8, only the dog group). Mean values based on all data obtained at 0 and 20 min during period 1-3 were compared between groups. A second, separate analysis for the dog group also included data from 60 min and for period 4. For the dog group fingertip temperature increased significantly between period 1 and 2, 1 and 3 and 1 and 4 (<i>p</i> < 0.05). In addition, fingertip temperature rose significantly between 0 and 20 min and between 0 and 60 min within all periods. For the control group a significant decrease in fingertip temperature was observed between period 1 and 3 (<i>p</i> < 0.05). Fingertip temperature did not differ between the two groups during period 1, but was significantly higher for the dog group than for the control group during periods 2 and 3 (<i>p</i> < 0.05 and <i>p</i> < 0.001, respectively). Cortisol results are only presented descriptively due to that many samples had too low volume of saliva to be analyzed. In the present study interaction between elderly residents and a visiting dog resulted in increased fingertip temperature, probably reflecting a decrease in the activity of the sympathetic nervous system and therefore a decrease in stress levels.
Introduction (2001)

The behavior of industrial plants and systems is in general determined by a number of physical and technical parameters. The values of these system parameters — in the following called variables — are fixed more and more with the help of optimization calculations. Based on a mathematical model of the system an optimization algorithm searches for those values of the variables, for which certain objective quantities take on a minimum (or a maximum).
A color animation system (1977)

This paper describes an animation package currently under development at the Cornell Program of Computer Graphics.The basic algorithm employed is linear or non-linear interpolation between successive pairs of key frames. These key frames are composed of artwork input by the animator on a graphic tablet and displayed on either a black and white vector scope or a color halftone CRT. The initial working environment is two-dimensional, and the individual images are combined using a multiplane cel animation technique to produce depth and motion illusions. Real-time film previewing, utilizing an on-the-fly interpolation algorithm, provides the artist with instant playback of animated sequences.
Spectral Filtering for Space-Domain Analysis of Periodic Structures (2006)

In the Method-of-Moments (MoM), applied to the Integral-Equation (IE) formulation for scattering or antenna problems, the solution (the unknown current) is approximated by a linear combination of a finite number of basis functions.
Switchable pH-Responsive Polymeric Membranes Prepared <i>via</i> Block Copolymer Micelle Assembly (2011)

A process is described to manufacture monodisperse asymmetric pH-responsive nanochannels with very high densities (pore density >2 × 10(14) pores per m(2)), reproducible in m(2) scale. Cylindric pores with diameters in the sub-10 nm range and lengths in the 400 nm range were formed by self-assembly of metal-block copolymer complexes and nonsolvent-induced phase separation. The film morphology was tailored by taking into account the stability constants for a series of metal-polymer complexes and confirmed by AFM. The distribution of metal-copolymer micelles was imaged by transmission electron microscopy tomography. The pH response of the polymer nanochannels is the strongest reported with synthetic pores in the nm range (reversible flux increase of more than 2 orders of magnitude when switching the pH from 2 to 8) and could be demonstrated by cryo-field emission scanning electron microscopy, SAXS, and ultra/nanofiltration experiments.
C‐Nitroso compounds. Part XXXVIII: Radical reactions of α‐chloro‐nitroso compounds with trialkylaluminium‐ether complexes (1986)

Abstract Ether complexes of trialkylaluminium compounds react with α‐chloro‐nitroso compounds via radicals which can abstract hydrogen from various solvents. In the presence of olefinic solvents, radical addition to the double bond also takes place. When the trialkylaluminium compounds are not complexed by ethers, they react with α‐chloro‐nitroso compounds predominantly via heterolytic processes 1,2 .
Collaborative Electrochemical Oxidation of the Alcohol and Aldehyde Groups of 5-Hydroxymethylfurfural by NiOOH and Cu(OH)<sub>2</sub> for Superior 2,5-Furandicarboxylic Acid Production (2022)

Electrochemical alcohol oxidation is considered a promising alternative to the oxygen evolution reaction due to the production of high-value products and early onset potential. Herein, we analyze the different reactivities of NiOOH and Cu(OH)2 toward the electrochemical oxidation of alcohol and aldehyde on the furan ring and utilize their characteristics synergistically to enhance the performance of 5-hydroxymethylfurfural (HMF) to 2,5-furandicarboxylic acid (FDCA) conversion. We discovered that Cu(OH)2 has higher reactivity for the oxidation of aldehyde to carboxylic acid than NiOOH, while NiOOH exhibited excellent reactivity toward the oxidation of alcohol to aldehyde. Furthermore, NiOOH–Cu(OH)2 mixed electrodes showed higher activity and faster conversion of HMF to FDCA than individual NiOOH or Cu(OH)2 electrodes. The alcohol oxidation of HMF is initiated by NiOOH, and Cu(OH)2 quickly converts the remaining aldehydes to carboxylic acids at the NiOOH/Cu(OH)2 interface. Further enhancement of the HMF oxidation kinetics of NiOOH/Cu(OH)2 was achieved by preparing a nanofoam structure comprising nanoscale pores and nanodendritic frames, showing instantaneous conversion to FDCA without producing unreacted intermediates.
Ultrawide Bandwidth Chip-to-Chip Interconnects for III-V MMICs (2013)

Ultrawide bandwidth coplanar waveguide interconnects between GaAs chips based on a novel fabrication process are demonstrated. Fabricated structures on 100 μm thick GaAs chips exhibited chip-to-chip insertion losses below 1 dB up to 110 GHz, and below 2.2 dB up to 220 GHz from on-wafer S-parameter measurements. A return loss larger than 10 dB from 100 MHz to 220 GHz was measured. The measured responses are consistent with numerical simulations, including the effects of excess solder at the chip-to-chip interface. Numerical simulations indicate that further improvements in performance, with insertion losses as low as 1.1 dB at 220 GHz, should be possible by minimizing the excess solder.
From a classic Renault Twizy towards a low cost autonomous car prototype: a proof of concept (2020)

This paper shows how a conventional electric car is modified into an autonomous vehicle. The starting point to the presented developments is the Renault Twizy® specially designed for urban mobility. The goal is to reuse the mechanical, electrical and electronic elements to customise this car in an autonomous electric vehicle. For that purpose, communication, actuators and sensors systems are added. The challenge here is double, on the one hand the integration challenge due to the small place offered by the Renault Twizy®, and on the other hand the proposed systems must associate low cost and good performances. The proof of concept of our autonomous prototype is given through some experimental validations.
Data from BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells (2023)

&lt;div&gt;AbstractPurpose:&lt;p&gt;BRAF and MEK inhibitors (BRAFi and MEKi) are actively used for the treatment of metastatic melanoma in patients with BRAF&lt;sup&gt;V600E&lt;/sup&gt; mutation in their tumors. However, the development of resistance to BRAFi and MEKi remains a difficult clinical challenge with limited therapeutic options available to these patients. In this study, we investigated the mechanism and potential therapeutic utility of combination BRAFi and adoptive T-cell therapy (ACT) in melanoma resistant to BRAFi.&lt;/p&gt;Experimental Design:&lt;p&gt;Investigations were performed &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; with various human melanoma cell lines sensitive and resistant to BRAFi as well as patient-derived xenografts (PDX) derived from patients. In addition, samples were evaluated from patients on a clinical trial of BRAFi in combination with ACT.&lt;/p&gt;Results:&lt;p&gt;Herein we report that in human melanoma cell lines, senstitive and resistant to BRAFi and in PDX from patients who progressed on BRAFi and MEKi therapy, BRAFi caused transient upregulation of mannose-6-phosphate receptor (M6PR). This sensitized tumor cells to CTLs via uptake of granzyme B, a main component of the cytotoxic activity of CTLs. Treatment of mice bearing resistant tumors with BRAFi enhanced the antitumor effect of patients' TILs. A pilot clinical trial of 16 patients with metastatic melanoma who were treated with the BRAFi vemurafenib followed by therapy with TILs demonstrated a significant increase of M6PR expression on tumors during vemurafenib treatment.&lt;/p&gt;Conclusions:&lt;p&gt;BRAF-targeted therapy sensitized resistant melanoma cells to CTLs, which opens new therapeutic opportunities for the treatment of patients with BRAF-resistant disease.&lt;/p&gt;&lt;p&gt;&lt;i&gt;See related commentary by Goff and Rosenberg, p. 2682&lt;/i&gt;&lt;/p&gt;&lt;/div&gt;
Increases in Whole Blood Glucose Measurements Using Optically Based Self-Monitoring of Blood Glucose Analyzers Due to Extreme Canadian Winters (2009)

It is probable that the seasonal variation of WBG arises from the very low indoor humidities that are associated with external subzero temperatures. These increases in WBG in cold weather may be due to limitations in the WBG measuring systems when operated in decreased humidities and/or increased evaporation of the blood sample during the blood glucose measurement process. The implications of this seasonal variation are significant in that it (1) introduces increased variability in patient WBG, (2) may result in increased glucose-lowering therapy during periods of external cold and low indoor humidity, and (3) confounds evaluations of WBG meter technology in geographic regions of subzero temperature and low indoor humidity. To mitigate the risk of diagnosing and treating factitious hyperglycemia, the humidity of patient care areas must be strictly controlled.
Breaking the silence: three bHLH proteins direct cell‐fate decisions during stomatal development (2007)

Stomata are microscopic pores on the surface of land plants used for gas and water vapor exchange. A pair of highly specialized guard cells surround the pore and adjust pore size. Studies in Arabidopsis have revealed that cell-cell communication is essential to coordinate the asymmetric cell divisions required for proper stomatal patterning. Initial research in this area identified signaling molecules that negatively regulate stomatal differentiation. However, genes promoting cell-fate transition leading to mature guard cells remained elusive. Now, three closely related basic helix-loop-helix (bHLH) proteins, SPEECHLESS, MUTE and FAMA have been identified as positive regulators that direct three consecutive cell-fate decisions during stomatal development. The identification of these genes opens a new direction to investigate the evolution of stomatal development and the conserved functions of bHLH proteins in cell type differentiation adopted by plants and animals.