gebhart/patrepeval huggingface dataset:
A Disturbance Attenuation Approach to Missile Guidance and Control. (1997)

Abstract : Solutions to stochastic control problems currently do not produce mechanizable missile control laws. To fill the gap without making excessive structure assumptions, it is suggested that the disturbance attenuation problem be extended to nonlinear guidance and control problems. The deterministic approach, which does not include all the properties of the stochastic control solution, does have characteristics which are quite appealing. For example, certain classes of partial information disturbance attenuation problems can be solved numerically essentially because variation methods are available. Over the three year period of the grant robust and adaptive guidance and control laws which are mechanizable with near future computer technology are developed which can meet system objectives in the presence of large uncertainties, system structural changes, and nonlinearities. Of particular importance emerging from our focus on disturbance attenuation is a new structure for adaptive control, new detection filters for detection and identifying structural changes, and methodologies for including system nonlinearites. Finally, a new multiple hypothesis adaptive estimator, using a single linear filter whose parameters are changing according to the on line computation of the probability of each hypothesis conditioned on the residual history, is shown to have better or equivalent performance to the current bank of filters concept with dramatic decrease In computation and ease of implementation.
ChemInform Abstract: NEW METHOD FOR THE SYNTHESIS OF GLYCOSYL GLYCERIDES. THE STEREOSELECTIVE REDUCTION OF GLYCOSIDES OF 1‐ALKOXY‐3‐HYDROXYACETONE (1982)

Abstract Das aus dem Glycerinmonoether (I) auf dem skizzierten Syntheseweg dargestellte Hydroxyacetonglycosid (V) läßt sich zum optisch aktiven Glyceringlucosid (VII) reduzieren, das als Vorstufe zu den Glycolipiden (VIII) dient.
Active Patch Antenna for Digital TV Receiver (2000)

This paper presents a broadband, low noise and high-gain active patch antenna for digital television receiver. The active antenna includes a broadband passive patch antenna and a one stage low noise bipolar amplifier. They are integrated on a Fr4 substrate. The frequency covers from 170MHz to230 MHz (VHF) and from 350MHz to 650 MHz (UHF).
504. Targeted Genome Engineering of Induced Pluripotent Stem Cells To Produce Auto-Regulated Inflammation Resistance for Musculoskeletal Regenerative Medicine (2015)

Chronic inflammatory diseases such as arthritis are characterized by aberrant and dysregulated responses to cytokines such as tumor necrosis factor α (TNFα). While exogenous anti-cytokine therapies have been shown to diminish this inflammatory response, they are often used at high, unregulated doses that can induce significant side effects. Here, we propose a novel regenerative medicine approach to treating such chronic inflammatory diseases by generating custom-designed cells that can execute real-time, user-defined responses to environmental cues, including pro-inflammatory cytokines. We designed and deployed gene editing nucleases based on the CRISPR/Cas9 system to create stem cells with the ability to antagonize TNFα-mediated inflammation in an auto-regulated, feedback-controlled manner for musculoskeletal regenerative medicine applications. Specifically, the cytokine-responsive Ccl2 gene was reprogrammed by nuclease-mediated integration of the gene encoding soluble TNFα receptor I (sTNFRI), a TNFα antagonist, immediately downstream of the Ccl2 promoter. Using a combination of qRT-PCR and site-specific integration of luciferase reporters, we observed increased transgene transcription in response to endogenous Ccl2 activation by treatment with TNFα. Transgene expression from engineered cells was feedback-controlled with rapid on/off dynamics (Fig 1 A). Importantly, engineered cells showed the ability to mitigate the inflammatory effects of TNFα in an auto-regulated manner within 48 hr of induction (Fig 1 B). Finally, while cartilage produced from control stem cells showed significant tissue degradation in response to TNFα, cartilage derived from engineered stem cells was protected from a 3-day treatment with 20 ng/ml TNFα, as evidenced by qRT-PCR, biochemical, and histological analyses (Fig 1C-G). This work demonstrates the utility of programmable nucleases for the development of “designer” stem cells with properties customized for regenerative medicine. Using CRISPR/Cas9, we engineered pluripotent stem cells with the user-specified trait of pro-inflammatory cytokine resistance. Our results show that genome engineering facilitated the rewiring of endogenous cell circuits in order to define novel input/output relationships between inflammatory mediators and their antagonists, achieving therapeutic benefit coupled to a rapidly responding, auto-regulated system. The customization of intrinsic cellular signaling pathways in therapeutic stem cell populations, as demonstrated in this work, can transform the landscape of regenerative medicine and open innovative possibilities for safer and more effective treatments applicable to a wide variety of diseases.
Deep Learning for Prediction of AMD Progression: A Pilot Study (2019)

A CNN with layer segmentation-based preprocessing shows strong predictive power for the progression of early/intermediate AMD to advanced AMD. Use of the preprocessing was shown to improve performance regardless of the network architecture.
Integrated VCSELs, MSM Photodetectors, and GaAs MESFETs for Low Cost Optical Interconnects (1997)

Vertical Cavity Surface Emitting Lasers (VCSELs) and Metal-Semiconductor-Metal (MSM) photodetectors are two key components for high speed optical data communication and optical interconnect modules. In this paper we report a successful integration of VCSELs and MSM photodetectors and GaAs MESFETs on semi-insulating (S.I.) substrate.
The anisotropic quasi-static permittivity of single-crystal <b> <i>β</i> </b>-Ga2O3 measured by terahertz spectroscopy (2020)

The quasi-static anisotropic permittivity parameters of electrically insulating beta gallium oxide (β-Ga2O3) were determined by terahertz spectroscopy. Polarization-resolved frequency domain spectroscopy in the spectral range from 200 GHz to 1 THz was carried out on bulk crystals along different orientations. Principal directions for permittivity were determined along crystallographic axes c and b and reciprocal lattice direction a*. No significant frequency dispersion in the real part of dielectric permittivity was observed in the measured spectral range. Our results are in excellent agreement with recent radio frequency capacitance measurements as well as with extrapolations from recent infrared measurements of phonon mode and high-frequency contributions and close the knowledge gap for these parameters in the terahertz spectral range. Our results are important for applications of β-Ga2O3 in high-frequency electronic devices.
Photoreactions with a Twist: Atropisomerism‐Driven Divergent Reactivity of Enones with UV and Visible Light (2016)

Light-induced transformation of atropisomeric and achiral enones displays divergent reactivity. Photocyclization leading to 3,4-dihydroquinolin-2-one was observed with achiral enone carboxamide, whereas the atropisomeric enone carboxamides underwent hydrogen abstraction leading to spiro-β-lactams. Detailed photochemical, photophysical, and theoretical investigations have provided insight into this divergent reactivity and selectivity.
Utility of the K-Means Clustering Algorithm in Differentiating Apparent Diffusion Coefficient Values of Benign and Malignant Neck Pathologies (2009)

The K-means clustering algorithm that generates partitions of large datasets may provide a better characterization of neck pathologies and may be of additional benefit in distinguishing benign and malignant neck pathologies compared with whole-lesion mean ADC alone.
Quantum-Chemical Investigation of Hydrocarbon Oxidative Dehydrogenation over Spin-Active Carbon Catalyst Clusters (2013)

Graphene-like carbon clusters with oxygen-saturated zigzag and armchair edges were used as models for density-functional theory investigations of the oxidative dehydrogenation (ODH) of hydrocarbon molecules over carbon catalysts. The product of the first elementary step of the reaction, which is either a hydrocarbon radical or a surface ether, is found to be strictly dependent on the spin multiplicity of the catalyst, although energies of the initial state are spin-degenerate. The barriers of the first step of the ODH of light hydrocarbons (methane, ethane, and propane) over zigzag-edge carbon clusters are higher (59–104 kJ/mol) than those for ethylbenzene (18–58 kJ/mol), and the barrier of the second H abstraction is generally rate-limiting (82–106 kJ/mol). The armchair edge is passive toward reaction with hydrocarbons, but it reacts almost without a barrier with hydrocarbon radicals. The barrier of reoxidation by O2 was found to decrease from 161 to 69 kJ/mol with an increasing level of saturation with H atoms.
A Scale Analysis Based Theoretical Force Balance Model for Critical Heat Flux (CHF) During Saturated Flow Boiling in Microchannels and Minichannels (2010)

Accurate prediction of critical heat flux (CHF) in microchannels and minichannels is of great interest in estimating the safe operational limits of cooling systems employing flow boiling. Scale analysis is applied to identify the relevant forces leading to the CHF condition. Using these forces, a local parameter model is developed to predict the flow boiling CHF. The theoretical model is an extension of an earlier pool boiling CHF model and incorporates force balance among the evaporation momentum, surface tension, inertia, and viscous forces. Weber number, capillary number, and a new nondimensional group introduced earlier by Kandlikar (2004, “Heat Transfer Mechanisms During Flow Boiling in Microchannels,” ASME J. Heat Transfer, 126, pp. 8–16), K2, representing the ratio of evaporation momentum to surface tension forces, emerged as main groups in quantifying the narrow channel effects on CHF. The constants in the model were calculated from the available experimental data. The mean error with ten data sets is 19.7% with 76% data falling within ±30% error band and 93% within ±50% error band. The length to diameter ratio emerged as a parameter indicating a stepwise regime change. The success of the model indicates that flow boiling CHF can be modeled as a local phenomenon and the scale analysis is able to reveal important information regarding fundamental mechanisms leading to the CHF condition.
Targeted Ultrasound Contrast Imaging of Tumor Vasculature With Positively Charged Microbubbles (2020)

Cationic microbubbles are easy to prepare. They selectively accumulate in the tumor vasculature after intravenous administration. These microbubbles provide target-to-control contrast ratio that can exceed an order of magnitude. Adherent microbubbles delineate the tumor mass at extended time points, at 30 minutes and beyond. This may allow for an extension of the contrast ultrasound examination time. Overall, positively charged microbubbles could become a universal ultrasound contrast agent for cancer imaging.
Gene therapy for rheumatoid arthritis. (2001)

Gene therapy was initially conceived of as a means of replacing defective genes in monogenic disorders such as cystic fibrosis or hemophilia, but has rapidly progressed into areas of medicine that involve a wide range of diseases including cancer, neurodegenerative disorders and autoimmunity. Elucidation of some of the cellular and molecular mechanisms implicated in the pathogenesis of joint inflammation and cartilage and bone destruction in inflammatory joint diseases such as rheumatoid arthritis (RA) have revealed novel targets for gene therapy. Strategies include the inhibition of pro-inflammatory cytokines, blockade of cartilage-degrading enzymes, inhibition of synovial cell activation or apoptosis of synovial cells, and manipulation of the Th1-Th2 cytokine balance. Both viral and non-viral gene transfer vector systems have been used to deliver therapeutic genes systemically or directly to arthritic joints by ex vivo as well as in vivo administration. Animal models of RA have been essential not only for better understanding the mechanisms of RA but also in serving as basic experimental tools to evaluate candidate gene products with anti-arthritic properties and develop therapeutic strategies.
A 3-D TCAD Framework for NBTI—Part I: Implementation Details and FinFET Channel Material Impact (2019)

The time kinetics of interface trap generation and passivation (ΔN <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IT</sub> ) and its contribution (ΔV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">IT</sub> ) during and after negative bias temperature instability (NBTI) stress is calculated by using Sentaurus TCAD. The framework consists of Sentaurus process for the formation of realistic device structures and to obtain material and strain information, while Sentaurus device is used to implement the double-interface reaction-diffusion (RD) model for trap kinetics. Capture-emission depassivation (CED) model is used for the inversion layer hole and oxide electric field (E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">OX</sub> )-assisted breaking of hydrogen (H) passivated defects at channel/gate insulator interface. Multistate configuration (MSC) model is used for diffusion of atomic and molecular hydrogen (H and H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) and further reactions with other H passivated defects in gate insulator bulk. Quantum effects are considered for hole density, and band structure calculation is used including mechanical strain for CED model parameters. Electron capture in the generated traps during recovery is calculated using transient trap occupancy model (TTOM) and implemented as a postprocessor. Measured data from silicon (Si) and silicon germanium (SiGe) p-channel FinFETs are used for validating the TCAD framework.
Sub-threshold startup charge pump using depletion MOSFET for a low-voltage harvesting application (2015)

This paper presents a fully integrated CMOS start-up circuit for a low voltage battery-less harvesting application. The proposed topology is based on a step-up charge pump using depletion transistors instead of enhancement transistors. With this architecture, we can obtain a self-starting voltage below the enhancement transistor's threshold due to its normally-on operation. The key advantages are the CMOS compatibility, inductor-less solution and no extra post-fabrication processing. The topology has been simulated in 0.18μm technology using a transistor-level model and has been compared to the traditional charge pump structure. The depletion-based voltage doubler charge pump enables operation from an input voltage as low as 250mV compared to 400mV in an enhancement-based one. The proposed topology can also achieve other conversion ratios such as 1:-1 inverter or 1:N step-up.
Draft Genome Resources for Brassicaceae Pathogens <i>Fusarium oxysporum</i> f. sp. <i>raphani</i> and <i>Fusarium oxysporum</i> f. sp. <i>rapae</i> (2021)

The soilborne filamentous fungus <i>Fusarium oxysporum</i> causes devastating diseases of many cultivated plant species. <i>F. oxysporum</i> f. sp. <i>raphani</i> and f. sp. <i>rapae</i> are two of four formae speciales that are pathogenic to Brassicaceae plants. Here, we present high-quality genome sequences of <i>F. oxysporum</i> f. sp. <i>raphani</i> strain Tf1262 and <i>F. oxysporum</i> f. sp. <i>rapae</i> strain Tf1208 that were isolated from radish (<i>Raphanus sativus</i>) and turnip (<i>Brassica rapa</i> var. <i>rapa</i>), respectively. These genome resources should facilitate in-depth investigation of interactions between <i>F. oxysporum</i> and Brassicaceae plants, and enable comparative genomics of the <i>F. oxysporum</i> species complex to uncover how pathogenicity evolved within <i>F. oxysporum</i>.[Formula: see text] Copyright © 2021 The Author(s). This is an open access article distributed under the CC BY 4.0 International license.
A π-gel scaffold for assembling fullerene to photoconducting supramolecular rods (2016)

Nonequilibrium self-assembly of molecules holds a huge prospect as a tool for obtaining new-generation materials for future applications. Crystallization of neutral molecules within a supramolecular gel matrix is one example in which two nonequilibrium processes occur orthogonal to each other. On the other hand, electronically interacting donor-acceptor two-component systems are expected to form phase-miscible hybrid systems. Contrary to the expectation, we report the behavior of a π-gel, derived from oligo(<i>p</i>-phenylenevinylene), OPVA, as a scaffold for the phase separation and crystallization of fullerene (C<sub>60</sub>) to supramolecular rods with increased transient photoconductivity (φƩμ<sub>max</sub> = 2.4 × 10<sup>-4</sup> cm<sup>2</sup> V<sup>-1</sup> s<sup>-1</sup>). The C<sub>60</sub> supramolecular rods in the π-gel medium exhibited high photocurrent in comparison to C<sub>60</sub> loaded in a non-π-gel medium. This finding provides an opportunity for large-scale preparation of micrometer-sized photoconducting rods of fullerenes for device application.
High-speed tuning of visible laser wavelength using a nanoimprinted grating optical tunable filter (2009)

We report on a microelectromechanical tunable optical filter incorporating strain-tunable nanoimprinted elastomeric grating with a pitch varied by 18%. This device enables tuning of optical fiber-guided laser wavelength between lambda=473 and 532 nm within 0.5 ms by mechanically modulating the pitch with a silicon microactuator. We also demonstrate the use of the device for obtaining two-color images of livedead-stained cells with the color intensity ratio varied by the actuator voltage applied. The small structure of the device integrated on a silicon chip may be used in portable systems for optical switching and spectroscopy.
Detecting Respiratory Effort-Related Arousals in Polysomnographic Data Using LSTM Networks (2018)

To diagnose sleep disorders, hours of sleep data from lots of different physiological sensors have to be analyzed. To do so, experts have to look through all the data which is time-consuming and error-prone. Automatic detection and classification of sleep related breathing disorders and arousals would significantly simplify this task. This years Physionet/CinC Challenge deals with this topic. This paper examines the use of a Long Short-Term Memory network for automatic arousal detection. On the test set, an AUPRC score of 0.14 was achieved.
Abstract 1272: Whole genome Crispr screening to identify potential SERD molecule resistance mechanisms (2019)

Abstract Metastatic breast cancer results in substantial morbidity and mortality for women afflicted with this disease. Approximately 80% of breast cancers express the estrogen receptor. The cancer cell survival and proliferation is driven by the activation of the estrogen receptor. SAR439859 is an effective endocrine therapy for breast cancer selectively and effectively degrading the estrogen receptor. A phase 1/2 study of SAR439859 alone and/or in combination with palbociclib in postmenopausal women with estrogen receptor positive advanced breast cancer was initiated last year by Sanofi. CRISPR/Cas9 is a recent and revolutionary technology for efficient and directed alterations of the genome. CRISPR allows users to introduce DNA double-strand breaks at precise locations in the genome using complementary guide RNAs (SgRNA). These double strand breaks can be repaired by non-homologous end joining DNA repair mechanism. This DNA repair mechanism is an error prone DNA repair process which can lead to gene invalidation. We aimed at investigating the potential SAR439859 resistance mechanisms. A better understanding of resistance mechanisms is needed to overcome this potential problem and to propose complementary therapeutic solutions. We conducted a whole genome CRISPR screening in a breast tumor cell line with a thermofisher commercial SgRNA library (ref: M04305) to identified genes involved in potential SAR439859 resistance phenomena. CRISPR screening steps will be presented from the cell line selections to results analysis. Citation Format: Christophe Marcireau, Karine Berthelot, Alice Williart, Hamida Fournet, Delphine Debono, Gilbert Thill, Helene Erasimus, Dorine Chassin, Christophe Lanneau, Veeanagouda Yaligara, Cecile Orsini, Michel Didier, Vincent Mikol, Monsif Bouaboula, Laurent Debussche. Whole genome Crispr screening to identify potential SERD molecule resistance mechanisms [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1272.
Audiovisual Speech Synchrony Detection by a Family of Bimodal Linear Prediction Models (2011)

Detecting whether the video of a speaking person in frontal head pose corresponds to the accompanying audio track is of interest in numerous multimodal biometrics-related applications. In many practical occasions, the audio and visual modalities may not be in sync; for example, we may observe static faces in images, the camera may be focusing on a nonspeaker, or a subject may be speaking in a foreign language with audio being translated to another language. Spoofing attacks in audiovisual biometric systems also often involve audio and visual data streams that are not in sync. Audiovisual (AV) synchrony indicates consistency between the audio and visual streams and thus the reliability for the segments to belong to the same individual. Such segments could then serve as building blocks for generating bimodal fingerprints of the different individuals present in the AV data, which can be important for security, authentication, and biometric purposes. AV segmentation can also be important for speaker turn detection, as well as automatic indexing and retrieval of different occurrences of a speaker.
Generation of free radicals and electrochemiluminescence from simple aromatic molecules in aqueous solutions (2006)

Oxide-covered aluminium electrodes were used to demonstrate that aromatic compounds, such as the simple derivatives of benzene, can be electrochemically excited at cathodically pulse-polarized conductor/insulator/electrolyte (C/I/E) tunnel junction electrodes (e.g. oxide-covered aluminium electrodes). The primary cathodic process at these electrodes was a tunnel emission of hot electrons into an aqueous electrolyte solution. Fluorescence (FL) and electrochemiluminescence (ECL) spectra were compared and the dependence of the electrochemiluminescence on the concentrations of benzene, toluene, phenol, p-cresol and aniline were measured and detailed mechanisms for the present electrochemiluminescence are proposed.
Supplementary Table S3-4 caption from NeoPalAna: Neoadjuvant Palbociclib, a Cyclin-Dependent Kinase 4/6 Inhibitor, and Anastrozole for Clinical Stage 2 or 3 Estrogen Receptor–Positive Breast Cancer (2023)

&lt;p&gt;The caption provides the title and description for the Supplementary Tables S3 adn S4.&lt;/p&gt;