gebhart/patrepeval huggingface dataset:
Combined effects of metformin and photobiomodulation improve the proliferation phase of wound healing in type 2 diabetic rats (2020)

We determined the impact of Photobiomodulation (PBM) and metformin administration alone and combined on the inflammation and proliferation steps of wound healing of incisions in type two diabetes mellitus (T2DM) rats. 40 rats were divided into 4 groups (n = 10 each group). A non-genetic model of T2DM was induced in all rats, and an incision was made on each rat. There were 4 groups as follows: Group 1 was control group. Group 2 received PBM alone (890 nm, 80 Hz, 0.324 J/cm<sup>2</sup>, daily). Group 3 received metformin alone (50 mg/kg, i.p., daily) and the fourth group received combination of PBM + metformin. At inflammation (day 4) and proliferation (day 7) steps, tensiometerical, stereological, and immunohistochemical examinations were performed. PBM and PBM + metformin treatments significantly increased wound strength at inflammation and proliferation steps of wound healing respectively. PBM, metformin, and PBM + metformin groups significantly decreased inflammatory cells at inflammation and proliferation steps of wound healing. PBM, metformin, and PBM + metformin groups significantly improved granulation tissue formation by increasing fibroblasts, and new blood vessel formation at inflammation and proliferation steps of wound healing. Metformin significantly increased M2 macrophages than other treatment groups at inflammation and proliferation steps of wound healing. Simultaneously, PBM significantly decreased M2 macrophages than control group. We concluded PBM and PBM + metformin treatments significantly hastened repair at the inflammation and proliferation steps of repairing skin injury in a non-genetic model of T2 DM. PBM + metformin showed a synergistic impact. There were not a positive relation between M2 macrophage number and wound strength in the studied groups. The details of the molecular mechanisms of PBM, and PBM + metformin treatments of repairing wounds in animals, and treatment of DFUs of patients with T2 DM should be elucidated by further research.
NF‐κB p50 subunit cross‐linking to DNA duplexes, containing a monosubstituted pyrophosphate internucleotide bond (1996)

The new express technique based on the use of BrCN to synthesize DNA duplexes, containing non-substituted or monosubstituted pyrophosphate internucleotide bonds has been proposed. Using this technique, DNA duplexes having modified internucleotide bonds between dT and dC residues in the human NF-kappaB transcription factor recognition sequence in HIV-1 (5'-GGAAAGTCCC-3') have been prepared. We demonstrate that these internucleotide bonds within the recognition site do not prevent the formation of NF-kappaB p50 subunit complex with the corresponding duplexes. The cross-linking of NF-kappaB p50 subunit to the DNA duplex containing a monosubstituted pyrophosphate internucleotide bond has been successfully performed.
Efficient water splitting over Na1−xKxTaO3 photocatalysts with cubic perovskite structure (2011)

This study improved the photocatalytic activity of NaTaO3 by replacing some Na ions in the 12-coordinate sites with larger K ions. Na1−xKxTaO3 photocatalysts of x = 0–0.2 were synthesized by the sol–gel method. K-doping at x = 0.05 resulted in rectifying the distorted perovskite NaTaO3 to a pseudo-cubic phase as well as significantly promoting the photocatalytic activity. The 180° bond angle of Ta–O–Ta in the pseudo-cubic phase may facilitate the separation of photogenerated charges for effective water splitting. Photoluminescence spectroscopic analysis confirmed that the flattened Ta–O–Ta linkage with K-doping suppresses the recombination of photogenerated charges. Further K-doping (with x > 0.05) leads to impurity formation, which bends the Ta–O–Ta linkage and creates defect states, lowering the photocatalytic activity of the K-doped NaTaO3. This study demonstrates that an appropriate ion replacement to tune the crystal structure can significantly promote electron transport in photocatalysts and thus their activity.
The Secretion-coupled Endocytosis Correlates with Membrane Tension Changes in RBL 2H3 Cells (1997)

Stimulated secretion in endocrine cells and neuronal synapses causes a rise in endocytosis rates to recover the added membrane. The endocytic process involves the mechanical deformation of the membrane to produce an invagination. Studies of osmotic swelling effects on endocytosis indicate that the increased surface tension is tightly correlated to a significant decrease of endocytosis. When rat basophilic leukemia (RBL) cells are stimulated to secrete, there is a dramatic drop in the membrane tension and only small changes in membrane bending stiffness. Neither the shape change that normally accompanies secretion nor the binding of ligand without secretion causes a drop in tension. Further, tension decreases within 6 s, preceding shape change and measurable changes in endocytosis. After secretion stops, tension recovers. On the basis of these results we suggest that the physical parameter of membrane tension is a major regulator of endocytic rate in RBL cells. Low tensions would stimulate endocytosis and high tensions would stall the endocytic machinery.
Continuous Authentication and Authorization for the Internet of Things (2017)

With the dawn of the Internet of Things, small but smart devices have become ubiquitous. Although these devices carry a lot of compute power and enable several interesting applications, they lack conventional interfaces such as keyboards, mice, and touchscreens. As a result, such devices can't authenticate and authorize users in familiar ways. Furthermore, unlike for conventional settings, a one-time authentication at the start of a session usually isn't appropriate for the IoT, because the application scenarios are dynamic and a user might not retain physical control or even awareness of IoT devices quite as readily as with traditional computers. Thus, users need to be continuously authenticated and authorized. Fortunately, the IoT offers interesting potential solutions for meeting these requirements. This article discusses some challenges and opportunities in developing continuous authentication and authorization approaches for the IoT while also presenting a case study of a Wi-Fi-based human authentication system called WiFiU.
A Novel Small Molecule Inhibitor of FAK and IGF-1R Protein Interactions Decreases Growth of Human Esophageal Carcinoma (2011)

A novel compound that disrupts the PPIs of FAK and IGF-1R results in decreased tumor proliferation and increased apoptosis. These effects appear to be mediated through downregulation of p-AKT and p-ERK. This compound deserves further study as a novel treatment strategy in patients with esophageal cancer.
OF NONPERSISTENT CSMA WITH POWER IN WIRELESS STAR-LIKE NETWORKS (1994)

ACT In this paper we present a model and analysis of asynchronous nonpersistent CSMA on a single-hop wireless network with a base station (e.g. the CDPD system), assuming power capture at the receiver. Power capture is a very important problem in wireless networks. A space-time model, which is more accurate than models in previous analyses, is used to track events in the network. Three capture models, yielding an upper and lower bounds on the throughput, are analyzed. Propagation loss and Rayleigh fading are assumed in capture models. Numerical and simulation results are obtained and discussed for different values of maximum normalized propagation delay and the capture ratio. In particular we show that the throughput for the lower bound model is very tight. In addition, we show t,hat fading, combined with propagation loss, improves the network throughput.
Position-Sensitive Detector (PSD) Guided Servoing Method for Industrial Robot Calibration (2009)

This article presents our recently developed position-sensitive detector (PSD) guided servoing system for precise localization of industrial robots. The system is portable and affordable, and can position robot precisely so as to benefit further research on the calibration applications of industrial robots. To achieve highly precise position feedback, we have employed a high performance lateral-effect PSD with a resolution of 0.5 µ m. Based on the system kinematics and dynamics, a PSD guided servo (PSDGS) control method is then developed and simplified to be a planar motion control approach in which an on-line estimation of the transformation matrix between the PSD object and the robot base is applied. The experiments have been implemented on an ABB industrial robot IRB1600. The achieved results demonstrate that the mean localization precision of the industrial robot using the developed PSDGS method is totally better than 20 µ m.
Conservative management of vestibular schwannomas - second review of a prospective longitudinal study (2004)

Vestibular schwannomas have been traditionally managed with microsurgical removal and in recent years, stereotactic radiotherapy. However, there is a group of patients in whom a conservative management approach might represent a desirable alternative. The aim of this study was to determine the natural history and outcome following the conservative management of 72 patients with unilateral vestibular schwannomas. This is a prospective cohort review of a previously published group of patients [Clin. Otolaryngol. (2000) 25, 28-39] with unilateral vestibular schwannoma that were initially analysed at our institution in 1998 [Walsh R.M., Bath A.P., Bance M.L. et al., Clin. Otolaryngol. (2000) 25, 28]. The mean duration of follow-up was 80 months (range 52-242 months). All the patients in the study underwent serial magnetic resonance imaging (MRI) for assessment of tumour growth. Patients were deemed to have failed conservative management if there was evidence of rapid radiological tumour growth and/or increasing signs and symptoms, which necessitated active intervention. The mean tumour growth rate for the entire group at the second review was 1 mm/year (range -0.84-9.65 mm/year). The mean growth rate for cerebellopontine angle tumours (1.3 mm/year) was significantly greater than that of internal auditory canal (IAC) tumours (0 mm/year) (P = 0.005). The majority of tumours (87.14%) grew <2 mm/year. There was significant tumour growth seen in 38.9%, no or insignificant growth in 41.7%, and negative growth in 19.4%. Twenty-three patients (32%) failed conservative management at the second review. There was no difference in the outcome of these failed patients in comparison with patients who underwent primary treatment without a period of conservative management. The mean growth rate of tumours in patients that failed conservative management (3.1 mm/year) was significantly greater than that in patients who did not fail (0.2 mm/year) (P < 0.001). No factors predictive of tumour growth or failure of conservative management were identified. Hearing deterioration with pure tone averages (0.5, 1, 2, 3 kHz) and speech discrimination scores occurred irrespective of tumour growth. This prospective study further emphasizes the role of conservative management in selected cases of vestibular schwannomas. Tumours in this study confined to the IAC typically demonstrated minimal or no growth on serial MRI scanning. Regular follow-up with interval scanning is mandatory in all patients.
Comparing time-frequency representations for directional derivative features (2014)

We compare the performance of Directional Derivatives features for automatic speech recognition when extracted from different time-frequency representations. Specifically, we use the short-time Fourier transform, Mel-frequency, and Gammatone spectrograms as a base from which we extract spectrotemporal modulations. We then assess the noise robustness of each representation with varied number of frequency bins and dynamic range compression schemes for both word and phone recognition. We find that the choice of dynamic range compression approach has the most significant impact on recognition performance. Whereas, the performance differences between perceptually motivated filter-banks are minimal in the proposed framework. Furthermore, this work presents significant gains in speech recognition accuracy for low SNRs over MFCCs, GFCCs, and Directional Derivatives extracted from the log-Mel spectrogram.
INNV-20. RADIOGRAPHIC RESPONSE AND SEIZURE CONTROL IN IDH1 MUTANT GLIOMA PATIENTS USING IVOSIDENIB (2021)

Abstract Isocitrate dehydrogenase 1 (IDH1) is commonly mutated in grade II-III gliomas, and the mutant enzyme leads to the production of the oncometabolite 2-hydroxyglutarate (2-HG). 2-HG is responsible for the gliomagenesis associated with these tumors and the promotion of seizures via glutamate receptors. Ivosidenib, a small molecule oral mIDH1 inhibitor, has shown promise in clinical trials to treat IDH1 mutant gliomas, and providers can utilize this agent in IDH1 mutant glioma patients. We evaluated our IDH1 mutant glioma patients treated off-label with ivosidenib and described the radiographic response and seizure control in this cohort when ivosidenib was initiated between October 2020 to February 2021. Radiographic response was determined using RANO criteria, and seizure control was determined by comparing seizures per month before and after initiation of ivosidenib. All patients represented received single-agent ivosidenib dosed at 500 mg orally once a day. One patient required a dose reduction to 250 mg orally once a day because of drug-induced diarrhea. In our cohort of six patients, patient age range was 31 to 74 years with four female patients and two male patients. Diagnoses represented were astrocytoma, IDH1 mutant (n=3) oligodendroglioma (WHO), IDH1 mutant, 1p19q co-deleted (n=2), and anaplastic astrocytoma IDH1 mutant (n=1). Three patients experienced a reduction of seizure frequency, two patients did not have seizures before or after therapy, and one patient remained with the same level of seizures (1 seizure/month). Radiographic responses recorded included three patients with stable disease, two patients with minor responses, and one patient with a partial response. Treatment with ivosidenib is ongoing for this cohort of mIDH1 glioma patients. Updated information on prolonged disease control and seizure control in this cohort of IDH1 mutant glioma patients will be presented. Therapeutics, such as ivosidenib, can lead to improved seizure control and radiographic outcomes in IDH1 mutant glioma patients.
Dataset supporting research into the production and analysis of multiply charged negative ions by atmospheric pressure matrix-assisted laser desorption/ionisation mass spectrometry (2018)

The dataset contains mass spectrometry data which was used as the basis for a published article focusing on the development of our in-house AP-MALDI ion source for negative ion production and analysis. The data is in the proprietary Waters .raw format, but can be converted to be viewed in free and open source software.
Induction of molecular remission by donor peripheral blood leukocyte therapy in patients relapsing with extramedullary blastic phase chronic myeloid leukemia after allogeneic bone marrow transplantation. (1998)

Two patients with chronic myeloid leukemia (CML) who relapsed in blastic transformation after allogeneic bone marrow transplantation (BMT) were treated with infusions of leukapheresed peripheral blood mononuclear cells from their original donor. At relapse, their disease was characterized by symptomatic extramedullary deposits of leukemia with minimal (PCR positive, cytologically negative) involvement of bone marrow. Treatment with donor cell infusions was associated with clinical remission, return of full donor chimerism and loss of the BCR-ABL transcript detectable in bone marrow before donor leukocyte infusion (molecular remission). Donor leukocyte infusions should be considered for therapy of relapsed blastic phase CML after allogeneic BMT, especially when the relapse is primarily extramedullary and responsive to local and systemic cytoreductive therapy. However, severe GVHD and CNS relapse remain obstacles to achieving a successful long-term outcome.
The anoctamin family: TMEM16A and TMEM16B as calcium‐activated chloride channels (2011)

The Ca(2+)-activated Cl(-) channels (CaCCs) are involved in a variety of physiological functions, such as transepithelial anion transport, smooth muscle contraction and olfaction. Recently, the question of the molecular identity of CaCCs has apparently been resolved with the identification of TMEM16A protein (also known as anoctamin-1). Expression of TMEM16A is associated with the appearance of Ca(2+)- and voltage-dependent Cl(-) currents with properties similar to those of native CaCCs. The putative structure of TMEM16A consists of eight transmembrane domains, with both the amino- and the carboxy-terminus protruding in the cytosol. TMEM16A is also characterized by the existence of different protein variants generated by alternative splicing. A close paralogue of TMEM16A, TMEM16B (anoctamin-2), is also associated with CaCC activity, although with different properties. The TMEM16B-dependent channels require higher intracellular Ca(2+) concentrations and have faster activation and deactivation kinetics. Expression of other anoctamins is devoid of detectable channel activity. These proteins, such as TMEM16F (anoctamin-6), may have different functions.
Adjuvant Abemaciclib Combined with Endocrine Therapy: Efficacy Results in monarchE Cohort 1 (2022)

The monarchE Cohort 1 patient population was enrolled based on high-risk clinicopathological features that can easily be identified as part of routine clinical breast cancer evaluation. Efficacy data from Cohort 1 demonstrate substantial evidence of benefit for adjuvant abemaciclib+ET in patients with HR+, HER2- early breast cancer at high risk of recurrence (ClinicalTrials.gov: NCT03155997 [monarchE]).
3D-Printed masks as a new approach for immobilization in radiotherapy - a study of positioning accuracy (2018)

We developed a new approach to produce individual immobilization devices for the head based on MRI data and 3D printing technologies. The purpose of this study was to determine positioning accuracy with healthy volunteers. 3D MRI data of the head were acquired for 8 volunteers. In-house developed software processed the image data to generate a surface mesh model of the immobilization mask. After adding an interface for the couch, the fixation setup was materialized using a 3D printer with acrylonitrile butadiene styrene (ABS). Repeated MRI datasets (n=10) were acquired for all volunteers wearing their masks thus simulating a setup for multiple fractions. Using automatic image-to-image registration, displacements of the head were calculated relative to the first dataset (6 degrees of freedom). The production process has been described in detail. The absolute lateral (x), vertical (y) and longitudinal (z) translations ranged between -0.7 and 0.5 mm, -1.8 and 1.4 mm, and -1.6 and 2.4 mm, respectively. The absolute rotations for pitch (x), yaw (y) and roll (z) ranged between -0.9 and 0.8°, -0.5 and 1.1°, and -0.6 and 0.8°, respectively. The mean 3D displacement was 0.9 mm with a standard deviation (SD) of the systematic and random error of 0.2 mm and 0.5 mm, respectively. In conclusion, an almost entirely automated production process of 3D printed immobilization masks for the head derived from MRI data was established. A high level of setup accuracy was demonstrated in a volunteer cohort. Future research will have to focus on workflow optimization and clinical evaluation.
Optimised Parameters for CIECAM02 Based Upon Surround Size Effect (2008)

This study investigates the effects of the size and the luminance value of the surround field on colour appearance under various viewing conditions. Ten phases of psychophysical experiments were conducted to obtain visual data assessed by a panel of 10-15 observers. The viewing conditions investigated include two sizes of surround field, three viewing distances, two luminance values of surround and three different sizes of stimuli. The accumulated visual data sets were used to test the CIE colour appearance model, CIECAM02, and the results showed that CIECAM02 gave a satisfactory prediction. Finally, the viewing parameters F, Nc and c in CIECAM02 were optimised to fit colour appearance results under different surround conditions. It was found a very small improvement.
Beyond full duplex wireless (2012)

Recent work has shown the possibility of implementing full-duplex wireless radios using commodity hardware. We discuss the possibility of extending full-duplex designs to support multiple input, multiple output (MIMO) systems. We explore how such a design could lead to a rethinking of wireless networks. We discuss various applications of full-duplex radios and the gains possible with those applications. We also discuss some of the challenges present in getting such radios and their applications to be a part of production networks.
Iron(<scp>II</scp>) complexes of polydentate aminopyridyl ligands and an exchangeable sixth ligand; reactions with peroxides. Crystal structure of [FeL<sup>1</sup>(H<sub>2</sub>O)][PF<sub>6</sub>]<sub>2</sub>·H<sub>2</sub>O [L<sup>1</sup>=N,N′-bis-(6-methyl-2-pyridylmethyl)-N,N′-bis(2-pyridylmethyl)ethane-1,2-diamine] (1995)

Iron(II) complexes of the pentadentate ligand N-methyl-N,N′,N′-tris(2-pyridylmethyl)ethane-1,2-diamine (L2) and the potentially hexadentate ligand N,N′-bis(6-methyl-2-pyridylmethyl)-N,N′-bis(2-pyridylmethyl)-N,N′-bis(2-pyridylmethyl)ethane-1,2-diamine (L1) have been isolated. Both ligands behave as pentadentate ligands in their iron(II) complexes with the general formulation [FeL(X)]n+(L = L1 or L2, n= 1 or 2) with the sixth co-ordination site (X) occupied by an auxiliary ligand e.g. H2O, Cl, SCN or CN. The crystal structure of [FeL1(H2O)][PF6]2·H2O 1 shows that the nitrogen atom of one of the 6-methyl-2-pyridylmethyl groups of the formally hexadentate ligand is not co-ordinated to the iron atom. Instead a water molecule occupies the sixth co-ordination position. Complex 1 crystallizes in the triclinic space group P, with a= 10.485(2), b= 13.161(5), c= 14.853(6)Å, α= 69.31(4), β= 74.42(3), γ= 66.37(3)° and Z= 2. The structure refined to a final R value of 0.052 for 2531 reflections. The complexes show peroxidase activity, the availability of a labile site on the relatively stable iron(II) complexes, along with no apparent tendency to form oxo-bridged diiron(III) species, which are likely to be crucial factors in the mechanism of the oxidation reactions. Efforts to isolate a complex with a co-ordinated peroxide in the sixth position were unsuccessful. However, we have spectroscopic evidence that peroxide reacts with the iron(II) complexes to form an unstable species, probably of the form [FeIIIL(OOR)]2+(L = L1 or L2, R = H or But). The peroxide ligand in this iron(III) complex is likely to be forced into an ‘end-on’ co-ordination mode.
A new methodology to analyze time sequences of ultrasound images (1991)

The [act that ultrasound scan lines are acquired in polar coordinates creates an important anisotropy in spatial resolution. The geometric transformation (called scan correction) w hich transforms the data from a polar representation to the correct cartesian representation is usually applied through a bilinear interpolation or Bresenham's scheme. We show in this paper the limitations of these schemes which do not account for the varying resolution of the data, and we propose an original method which consists in computing the scan-conversion with a low-pass filtering of the cartesian image applied directly ta the available polar data. We then generalize this approach to extract edges at various resolutions and show how to use these edges to track sorne important moving structures through a dynamic temporal sequence. This is done by combining a refined edge detection (using temporal information) with classical deformable models (snakes). We present our results on a temporal sequence of 24 ultrasound images of the beating heart.