gebhart/patrepeval huggingface dataset:
Augmenting night vision video images with longer distance road course information (2013)

Today's night vision driver assistance systems help the driver by displaying an infrared image and detecting and highlighting other road users such as pedestrians or cyclists. To further increase active safety, future night vision systems could also visualize road course information. Especially the road courses at greater distances can help drivers interpret upcoming scenes. However, longer distance road course estimation is a challenging task because on-board sensors have a limited viewing range. This paper proposes a sensor fusion system that employs digital map information in combination with radar and camera sensors to estimate the 3D road course even at longer distances. The positioning task on the digital map is solved by a Bayesian framework that estimates position probability by means of map registration. By fusing road course data from the digital map and an optical lane recognition module, an accurate 3D road course estimation is obtained.
Elucidation of the Mode of Action of a New Antibacterial Compound Active against Staphylococcus aureus and Pseudomonas aeruginosa (2016)

Nosocomial and community-acquired infections caused by multidrug resistant bacteria represent a major human health problem. Thus, there is an urgent need for the development of antibiotics with new modes of action. In this study, we investigated the antibacterial characteristics and mode of action of a new antimicrobial compound, SPI031 (N-alkylated 3, 6-dihalogenocarbazol 1-(sec-butylamino)-3-(3,6-dichloro-9H-carbazol-9-yl)propan-2-ol), which was previously identified in our group. This compound exhibits broad-spectrum antibacterial activity, including activity against the human pathogens Staphylococcus aureus and Pseudomonas aeruginosa. We found that SPI031 has rapid bactericidal activity (7-log reduction within 30 min at 4x MIC) and that the frequency of resistance development against SPI031 is low. To elucidate the mode of action of SPI031, we performed a macromolecular synthesis assay, which showed that SPI031 causes non-specific inhibition of macromolecular biosynthesis pathways. Liposome leakage and membrane permeability studies revealed that SPI031 rapidly exerts membrane damage, which is likely the primary cause of its antibacterial activity. These findings were supported by a mutational analysis of SPI031-resistant mutants, a transcriptome analysis and the identification of transposon mutants with altered sensitivity to the compound. In conclusion, our results show that SPI031 exerts its antimicrobial activity by causing membrane damage, making it an interesting starting point for the development of new antibacterial therapies.
Abstract 2286: XmAb30819, an XmAb®2+1 ENPP3 x CD3 bispecific antibody for RCC, demonstrates safety and efficacy in in vivo preclinical studies (2020)

Abstract Bispecific T cell engagers simultaneously bind CD3 on T cells and tumor-associated antigens to promote T cell-mediated killing of tumor cells. While targeting lineage-restricted antigens such as CD19 or CD20 have found clinical success in hematopoietic cancers, targeting solid tumors requires high expressing tumor associated antigens (TAAs) with minimal normal tissue expression. One underexplored TAA is ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3) for renal cell carcinoma (RCC). An activation marker for basophils, ENPP3 is a type II transmembrane protein that can promiscuously hydrolyze a large variety of nucleotide-containing molecules. Although its specific function in the tumor microenvironment is unknown, bulk RNAseq data from the TCGA describes broad overexpression of ENPP3 in clear cell and papillary RCC and less frequently in hepatocellular carcinoma (HCC). This pattern of expression has been confirmed by IHC and makes ENPP3 a potential target for a CD3 bispecific approach. Building upon the XmAb® heterodimeric Fc platform, we generated bispecific antibodies in an XmAb 2+1 Fab2-scFv-Fc format that are bivalent for ENPP3 and monovalent for CD3. Reducing the affinity of both specificities encouraged avid binding and strong potency on high ENPP3 expressing cell lines while minimizing reactivity on low expressing cell lines, matching ENPP3's differential expression pattern. In vitro T cell-dependent cellular cytotoxicity (TDCC) assays on the relevant cell lines confirmed selective potency on high versus low expressing cells. In vivo potency was evaluated by xenograft tumor models in human PBMC-engrafted NSG mice. In a KU812 tumor model, the lead candidate, XmAb30819, exhibited complete responses both as a single agent and in combination with checkpoint blockade. When tested against RXF393, an RCC cell line that overexpresses ENPP3 upon tumor engraftment, XmAb30819 demonstrated complete responses at all tested doses. Tolerability in non-human primates was evaluated in an escalating dose model and then confirmed in an expansion cohort. Dose-dependent T cell margination was observed, and doses that were active in the mouse tumor studies were well-tolerated. Preclinical studies have demonstrated the safety and efficacy of XmAb30819, an XmAb 2+1 ENPP3 x CD3 bispecific antibody for RCC. Citation Format: Alex Nisthal, Sung-Hyung Lee, Yoon Kyung Kim, Christine Bonzon, Rumana Rashid, Kendra N. Avery, Liz Bogaert, Connie Ardila, Irene W. Leung, Nicole Rodriguez, Umesh S. Muchhal, Gregory L. Moore, Seung Y. Chu, John R. Desjarlais. XmAb30819, an XmAb®2+1 ENPP3 x CD3 bispecific antibody for RCC, demonstrates safety and efficacy in in vivo preclinical studies [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 2286.
Traffic-aware non-uniform passband assignment in elastic optical networks (2015)

We propose a globally traffic-aware passband assignment algorithm to satisfy signal integrity requirements in elastic optical networks. We implement our solution in an SDN-enabled testbed and demonstrate successful performance with DQPSK and OFDM modulation formats.
Interconnect design considerations for large NUCA caches (2007)

The ever increasing sizes of on-chip caches and the growing domination of wire delay necessitate significant changes to cache hierarchy design methodologies. Many recent proposals advocate splitting the cache into a large number of banks and employing a network-on-chip (NoC) to allow fast access to nearby banks (referred to as Non-Uniform Cache Architectures--NUCA). Most studies on NUCA organizations have assumed a generic NoC and focused on logical policies for cache block placement, movement, and search. Since wire/router delay and power are major limiting factors in modern processors, this work focuses on interconnect design and its influence on NUCA performance and power. We extend the widely-used CACTI cache modeling tool to take network design parameters into account. With these overheads appropriately accounted for, the optimal cache organization is typically very different from that assumed in prior NUCA studies. To alleviate the interconnect delay bottleneck, we propose novel cache access optimizations that introduce heterogeneity within the inter-bank network. The careful consideration of interconnect choices for a large cache results in a 51% performance improvement over a baseline generic NoC and the introduction of heterogeneity within the network yields an additional 11-15% performance improvement.
The Role of Metabolites in the Link between DNA Replication and Central Carbon Metabolism in Escherichia coli (2020)

A direct link between DNA replication regulation and central carbon metabolism (CCM) has been previously demonstrated in <i>Bacillus subtilis</i> and <i>Escherichia coli</i>, as effects of certain mutations in genes coding for replication proteins could be specifically suppressed by particular mutations in genes encoding CCM enzymes. However, specific molecular mechanism(s) of this link remained unknown. In this report, we demonstrate that various CCM metabolites can suppress the effects of mutations in different replication genes of <i>E. coli</i> on bacterial growth, cell morphology, and nucleoid localization. This provides evidence that the CCM-replication link is mediated by metabolites rather than direct protein-protein interactions. On the other hand, action of metabolites on DNA replication appears indirect rather than based on direct influence on the replication machinery, as rate of DNA synthesis could not be corrected by metabolites in short-term experiments. This corroborates the recent discovery that in <i>B. subtilis</i>, there are multiple links connecting CCM to DNA replication initiation and elongation. Therefore, one may suggest that although different in detail, the molecular mechanisms of CCM-dependent regulation of DNA replication are similar in <i>E. coli</i> and <i>B. subtilis</i>, making this regulation an important and common constituent of the control of cell physiology in bacteria.
Tandem mass spectrometer for the detection of nitroaromatic compounds and other electronegative species in ambient air (1985)

A tandem mass spectrometer has been constructed consisting of a quadrupole mass filter followed by a time-of-flight mass spectrometer. Ions are generated in an atmospheric pressure ionization (API) source, which allows for detection of certain types of compounds in ambient air. The combination of API with this tandem mass spectrometer offers the potential to do real-time monitoring of targeted compounds that are of environmental and other concern. 5 figs.
Autonomous navigation using x-ray pulsars and multirate processing (2017)

In this paper, autonomous pulsar-based spacecraft navigation problem is formulated in terms of a nonlinear filtering problem. The spacecraft dynamics, pulsar-timing model, and clock deviation model are combined to form the navigation system. An extended Kalman filter that uses epoch folding and leverages the timescale of the system is developed to more efficiently estimate the spacecraft states from four simultaneous X-ray pulsar measurements. Simulation results of an orbiter mission and a deep space mission are presented to show the accuracy of pulsar-based navigation in space.
Cabotegravir long acting injection protects macaques against intravenous challenge with SIVmac251 (2016)

These results support the clinical investigation of CAB long acting as PrEP in people who inject drugs.
Contact Lenses Delivering Nitric Oxide under Daylight for Reduction of Bacterial Contamination (2019)

Ocular infection due to microbial contamination is one of the main risks associated with the wearing of contact lens, which demands novel straightforward strategies to find reliable solutions. This contribution reports the preparation, characterization and biological evaluation of soft contact lenses (CL) releasing nitric oxide (NO), as an unconventional antibacterial agent, under daylight exposure. A tailored NO photodonor (NOPD) was embedded into commercial CL leading to doped CL with an excellent optical transparency (transmittance = 100%) at λ ≥ 450 nm. The NOPD results homogeneously distributed in the CL matrix where it fully preserves the photobehavior exhibited in solution. In particular, NO release from the CL and its diffusion in the supernatant physiological solution is observed upon visible light illumination. The presence of a blue fluorescent reporting functionality into the molecular skeleton of the NOPD, which activates concomitantly to the NO photorelease, allows the easy monitoring of the NO delivery in real-time and confirms that the doped CL work under daylight exposure. The NO photoreleasing CL are well-tolerated in both dark and light conditions by corneal cells while being able to induce good growth inhibition of <i>Staphylococcus aureus</i> under visible light irradiation. These results may pave the way to further engineering of the CL with NOPD as innovative ocular devices activatable by sunlight.
&lt;title&gt;Detection and classification of concealed weapons using a magnetometer-based portal&lt;/title&gt; (2002)

A concealed weapons detection technology was developed through the support of the National Institute of Justice (NIJ) to provide a non intrusive means for rapid detection, location, and archiving of data (including visual) of potential suspects and weapon threats. This technology, developed by the Idaho National Engineering and Environmental Laboratory (INEEL), has been applied in a portal style weapons detection system using passive magnetic sensors as its basis. This paper will report on enhancements to the weapon detection system to enable weapon classification and to discriminate threats from non-threats. Advanced signal processing algorithms were used to analyze the magnetic spectrum generated when a person passes through a portal. These algorithms analyzed multiple variables including variance in the magnetic signature from random weapon placement and/or orientation. They perform pattern recognition and calculate the probability that the collected magnetic signature correlates to a known database of weapon versus non-weapon responses. Neural networks were used to further discriminate weapon type and identify controlled electronic items such as cell phones and pagers. False alarms were further reduced by analyzing the magnetic detector response by using a Joint Time Frequency Analysis digital signal processing technique. The frequency components and power spectrum for a given sensor response were derived. This unique fingerprint provided additional information to aid in signal analysis. This technology has the potential to produce major improvements in weapon detection and classification.
Severe intraprocedural complications during TAVI – calling for a heart team based approach (2013)

Aims: Transcatheter aortic valve implantation (TAVI) has emerged rapidly. Despite unanimous recommendations and potentially fatal intraoperative complications, the heart-team approach is not comprehensively performed by all centers. We sought to characterize severe intraprocedural complications during TAVI requiring immediate surgical or interventional bailout maneuvers and evaluate outcomes.
HIV testing among pregnant women living with HIV in India: are private healthcare providers routinely violating women’s human rights? (2014)

There is an urgent need for capacity building among private healthcare providers to improve standards of practice with regard to informed consent process, HIV testing, patient confidentiality, treatment, and referral of pregnant women living with HIV.
Executive summary of the 2020 KDIGO Diabetes Management in CKD Guideline: evidence-based advances in monitoring and treatment (2020)

Improving Global Outcomes (KDIGO) Clinical Practice Guideline for Diabetes Management in Chronic Kidney Disease represents the first KDIGO guideline on this subject. The guideline comes at a time when advances in diabetes technology and therapeutics offer new options to manage the large population of patients with diabetes and chronic kidney disease (CKD) at high risk of poor health outcomes. An enlarging base of high-quality evidence from randomized clinical trials is available to evaluate important new treatments offering organ protection, such as sodium-glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists. The goal of the new guideline is to provide evidence-based recommendations to optimize the clinical care of people with diabetes and CKD by integrating new options with existing management strategies. In addition, the guideline contains practice points to facilitate implementation when insufficient data are available to make well-justified recommendations or when additional guidance may be useful for clinical application. The guideline covers comprehensive care of patients with diabetes and CKD, glycemic monitoring and targets, lifestyle interventions, antihyperglycemic therapies, and self-management and health systems approaches to management of patients with diabetes and CKD.
AUREOCHROME1a-Mediated Induction of the Diatom-Specific Cyclin <i>dsCYC2</i> Controls the Onset of Cell Division in Diatoms (<i>Phaeodactylum tricornutum</i>) (2013)

Cell division in photosynthetic organisms is tightly regulated by light. Although the light dependency of the onset of the cell cycle has been well characterized in various phototrophs, little is known about the cellular signaling cascades connecting light perception to cell cycle activation and progression. Here, we demonstrate that diatom-specific cyclin 2 (dsCYC2) in Phaeodactylum tricornutum displays a transcriptional peak within 15 min after light exposure, long before the onset of cell division. The product of dsCYC2 binds to the cyclin-dependent kinase CDKA1 and can complement G1 cyclin-deficient yeast. Consistent with the role of dsCYC2 in controlling a G1-to-S light-dependent cell cycle checkpoint, dsCYC2 silencing decreases the rate of cell division in diatoms exposed to light-dark cycles but not to constant light. Transcriptional induction of dsCYC2 is triggered by blue light in a fluence rate-dependent manner. Consistent with this, dsCYC2 is a transcriptional target of the blue light sensor AUREOCHROME1a, which functions synergistically with the basic leucine zipper (bZIP) transcription factor bZIP10 to induce dsCYC2 transcription. The functional characterization of a cyclin whose transcription is controlled by light and whose activity connects light signaling to cell cycle progression contributes significantly to our understanding of the molecular mechanisms underlying light-dependent cell cycle onset in diatoms.
Purple Acid Phosphatase5 is required for maintaining basal resistance against Pseudomonas syringaein Arabidopsis (2013)

Taken together, our results demonstrate the requirement of PAP5 for maintaining basal resistance against Pst DC3000. Furthermore, our results provide evidence that PAP5 acts upstream of SA accumulation to regulate the expression of other defense responsive genes. We also provide the first experimental evidence indicating the role PAP5 in plant defense responses.
Investigation of a Model-Assisted Approach to Probability of Detection Evaluation (2007)

This paper presents a model‐assisted probability of detection (MAPOD) study for inspection of a two‐layer airframe structure. Eddy current measurements for varying crack length around fastener holes in a two‐layer aluminum structure are studied using both experimental and model‐generated data. New statistical algorithms are used to calculate the probability of detection. Good agreement was achieved between empirical and model‐assisted approaches.
Conformational studies on model compounds of polyamides with ether groups in their structure (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTConformational studies on model compounds of polyamides with ether groups in their structureJ. de Abajo, J. G. de la Campa, E. Riande, J. M. Garcia, and M. L. JimenoCite this: J. Phys. Chem. 1993, 97, 33, 8669–8674Publication Date (Print):August 1, 1993Publication History Published online1 May 2002Published inissue 1 August 1993https://pubs.acs.org/doi/10.1021/j100135a022https://doi.org/10.1021/j100135a022research-articleACS PublicationsRequest reuse permissionsArticle Views145Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Joint Power and Quantization Optimization for Target Tracking in Wireless Sensor Networks (2008)

Consider a scenario where a subset of sensors has been selected for target tracking in an energy-constrained wireless sensor network. They communicate their quantized state measurements over noisy Rayleigh fading channels to a fusion center, where centralized estimation of target state is performed. In this context, we consider the problem of determining optimum quantization bits and transmission power per bit for all sensors such that both resource utilization and overall estimation error at the fusion center are minimized. Unlike prior efforts, we incorporate the operating state (characterized by the amount of residual battery power) of the sensors in the optimization framework. Analytical solutions for optimum power and number of quantization bits are derived and validated with numerical examples through simulations. We study the effect of channel quality, local measurement noise, and operating states of the sensors on their optimum choice for quantization bits and transmit power per bit.
Structure and dynamics of the interface between a Ag single crystal electrode and an aqueous electrolyte (2002)

The aim of this work is to elucidate the initial steps of the electrochemical oxidation of Ag(111) in alkaline electrolytes. We use electrochemical as well as ex situ (XPS) and in situ (SHG) spectroscopic techniques to reconstruct the Ag(111)/electrolyte interface as a complex dynamic entity. Moving in the direction from negative to positive potentials we first observe specific adsorption of hydroxide ions, which starts at ca. -1.1 V vs. Ag/Ag2O in 0.1 M NaOH. SHG data prove that hydroxide retains its negative charge. At -0.3 V oxidation of the surface sets in with the formation of negatively charged adsorbed oxygen species and Ag+ ions, which give rise to peaks at 528.2 +/- 0.2 eV and at 367.7 eV in the O 1s and the Ag 3d(5/2) XP spectra, respectively. Around -0.1 V the adlayer is transformed into an ordered surface oxide phase which grows via a nucleation and growth mechanism. Above the reversible Ag/Ag2O potential the 2D Ag(I) oxide transforms into a 3D Ag(I) oxide. The electrochemical oxidation is compared with the previously studied gas-phase process, demonstrating both remarkable similarities as well as some differences.
Zr‐Based Thin‐Film Metallic Glass for Bipolar Plate in Proton Exchange Membrane Fuel Cells (2020)

Many researchers have tried to use metallic glass alloys in bipolar plates because of their unique properties such as their higher mechanical strength and corrosion resistances, recently. Thin‐film metallic glasses (TFMGs), herein, are coated on an austenitic stainless steel (AISI 316L) plate to enhance the corrosion properties of the metallic bipolar plate. A crystallized alloying target with the composition Zr 63.9 Al 10 Cu 26.1 and a grain size of less than 1 μm is prepared by consolidating the amorphous powder at 800 °C for 30 min. Also, TFMGs are coated on the AISI 316L plate using direct current (DC) magnetron sputtering system. The contact resistance of the TFMG is decreased by 24 mΩ cm 2 by controlling the surface roughness of the AISI 316L plate. The corrosion current densities of the TFMGs are less than 1 μA cm −2 under both anodic and cathodic conditions, and there are no changes of the current density in the range of potentials of 0.6–1.2 V which corresponds to the operating conditions of a proton exchange membrane (PEM) fuel cell. Based on this result, it is believed that these TFMGs can be a potential candidate coating materials for metallic bipolar plate in PEM fuel cell.