gebhart/patrepeval huggingface dataset:
High Plasma Vasopressin during Early Post-Operative Diabetes Insipidus (1986)

Conference Abstract| January 01 1986 High Plasma Vasopressin during Early Post-Operative Diabetes Insipidus J.R. Seckl; J.R. Seckl 1Medical Unit, Charing Cross and Westminster Medical School, SW1 Search for other works by this author on: This Site PubMed Google Scholar D. Dunger; D. Dunger *Institute of Child Health, WC1 Search for other works by this author on: This Site PubMed Google Scholar S.L. Lightman S.L. Lightman 1Medical Unit, Charing Cross and Westminster Medical School, SW1 Search for other works by this author on: This Site PubMed Google Scholar Clin Sci (Lond) (1986) 70 (s13): 39P. https://doi.org/10.1042/cs070039Pb Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter LinkedIn Cite Icon Cite Get Permissions Citation J.R. Seckl, D. Dunger, S.L. Lightman; High Plasma Vasopressin during Early Post-Operative Diabetes Insipidus. Clin Sci (Lond) 1 January 1986; 70 (s13): 39P. doi: https://doi.org/10.1042/cs070039Pb Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll JournalsClinical Science Search Advanced Search This content is only available as a PDF. © 1986 The Biochemical Society and the Medical Research Society1986 Article PDF first page preview Close Modal You do not currently have access to this content.
Optimizing the fluid dispensing process for immersion lithography (2004)

The concept behind immersion lithography is the insertion of a high refractive index liquid in the space between the final projection lens of an exposure system and the device wafer to improve the overall resolution of the exposure process. Computational fluid dynamics (CFD) simulations were performed in order to investigate the process of initially filling the lens-wafer gap with immersion fluid. The CFD models were used to investigate the effects of dispense velocity, gap height, and fluid dispense angle on the fill process; specifically on the possibility of air entrainment. The simulations revealed that there is an optimal region in the parameter space of gap height and dispense velocity for which the gap fills completely. Outside of this region, either excessive inertial or surface tension forces cause an undesirable, incomplete filling process. The optimal region was found to shift somewhat based on the fluid dispense angle. Finally, experiments were performed to verify the CFD models. The CFD simulations and the experimental results were in good agreement, both qualitatively with regard to the shape and evolution of the free surface and quantitatively with regard to the velocity of the contact line.
Low dose naltrexone inhibits the progression of clinical disease in established relapse‐remitting experimental autoimmune encephalomyelitis ő a model for multiple sclerosis (651.3) (2014)

Relapse‐remitting multiple sclerosis (RR‐MS) is a chronic disorder involving inflammatory attacks on the CNS. RR‐MS affects about 350,000 people in the U.S. significantly reducing the quality of life. The Opioid Growth Factor (OGF)‐Opioid Growth Factor Receptor (OGFr) pathway has been reported to be involved in experimental autoimmune encephalomyelitis (EAE). Blockade of OGF‐OGFr interaction using low dosages of the opioid antagonist naltrexone (LDN) alters the course of disease. SJL/J mice were immunized with PLP139‐151, and were injected (ip) daily with 0.1 mg/kg naltrexone or saline beginning 2 days after initial signs of disease. Within 9 days of LDN treatment mice had markedly reduced mean behavioral scores compared to controls, with the sum of behavioral scores being 142.9±11.5 for the RR‐EAE+Saline group in comparison to 78.8±9.1for the RR‐EAE+LDN group. In the LDN group, 80% of the mice had complete remission (behavioral scores of 0.5 or less) during the 40 day observation period. Moreover, LDN‐treated mice demonstrated a 4‐fold increase in mild disease scores relative to controls. The results indicate that modulation of the OGF‐OGFr pathway by LDN in established RR‐EAE inhibited the severity of initial flair and limited the progression of clinical disease, with many LDN‐treated mice showing complete remission. These observations support LDN as a non‐toxic/safe biotherapy for the treatment of RR‐MS. Grant Funding Source : Shockey Family Foundation
Fuel Assisted Idle Speed Control for Lean Burn Gasoline Engines (2006)

&lt;div class="htmlview paragraph"&gt;Reduced engine idle speed reduces fuel consumption but requires active idle speed control (ISC) to avoid stalls due to accessory load disturbances. For gasoline engines, spark advance is used in conjunction with air flow for the idle speed control. However, for spark control to be effective the nominal spark timing has to be retarded from the optimal timing to allow spark to increase torque. This offsets the fuel consumption benefit from lower speeds. During lean homogenous operating modes, Fuel Assisted ISC (FA-ISC) uses fuel to increase torque (similar to diesel and gasoline stratified charge) eliminating the need for the retarded nominal spark. The engine then operates close to optimal spark and the lean air fuel limit for optimal fuel economy.&lt;/div&gt;
Multidentate <sup>18</sup>F-Polypegylated Styrylpyridines As Imaging Agents for Aβ Plaques in Cerebral Amyloid Angiopathy (CAA) (2011)

β-Amyloid plaques (Aβ plaques) in the brain are associated with cerebral amyloid angiopathy (CAA). Imaging agents that could target the Aβ plaques in the living human brain would be potentially valuable as biomarkers in patients with CAA. A new series of (18)F styrylpyridine derivatives with high molecular weights for selectively targeting Aβ plaques in the blood vessels of the brain but excluded from the brain parenchyma is reported. The styrylpyridine derivatives, 8a-c, display high binding affinities and specificity to Aβ plaques (K(i) = 2.87, 3.24, and 7.71 nM, respectively). In vitro autoradiography of [(18)F]8a shows labeling of β-amyloid plaques associated with blood vessel walls in human brain sections of subjects with CAA and also in the tissue of AD brain sections. The results suggest that [(18)F]8a may be a useful PET imaging agent for selectively detecting Aβ plaques associated with cerebral vessels in the living human brain.
Psychophysical evidence for a magnocellular pathway deficit in dyslexia (1998)

The relationship between reading ability and psychophysical performance was examined to test the hypothesis that dyslexia is associated with a deficit in the magnocellular (M) pathway. Speed discrimination thresholds and contrast detection thresholds were measured under conditions (low mean luminance, low spatial frequency, high temporal frequency) for which psychophysical performance presumably depends on M pathway integrity. Dyslexic subjects had higher psychophysical thresholds than controls in both the speed discrimination and contrast detection tasks, but only the differences in speed thresholds were statistically significant. In addition, there was a strong correlation between individual differences in speed thresholds and reading rates. These results support the hypothesis for an M pathway abnormality in dyslexia, and suggest that motion discrimination may be a more sensitive psychophysical predictor of dyslexia than contrast sensitivity.
&lt;title&gt;Relative variation of stress-optic coefficient with wavelength in fused silica and calcium fluoride&lt;/title&gt; (1999)

Birefringence in refractive components such as lenses has become an increasingly serious problem in semiconductor lithography as exposure wavelength decreases. Most measurements of birefringence are made with visible light but the light used for photolithography is in the UV and deep UV spectral regions. Measurements of the relative variation of stress-optic constants have been made for fused silica and calcium fluoride, the two primary transmissive optical materials used by this industry.
Integrating Internal Standards into Disposable Capillary Electrophoresis Devices To Improve Quantification (2017)

To improve point-of-care quantification using microchip capillary electrophoresis (MCE), the chip-to-chip variabilities inherent in disposable, single-use devices must be addressed. This work proposes to integrate an internal standard (ISTD) into the microchip by adding it to the background electrolyte (BGE) instead of the sample-thus eliminating the need for additional sample manipulation, microchip redesigns, and/or system expansions required for traditional ISTD usage. Cs and Li ions were added as integrated ISTDs to the BGE, and their effects on the reproducibility of Na quantification were explored. Results were then compared to the conclusions of our previous publication which used Cs and Li as traditional ISTDs. The in-house fabricated microchips, electrophoretic protocols, and solution matrixes were kept constant, allowing the proposed method to be reliably compared to the traditional method. Using the integrated ISTDs, both Cs and Li improved the Na peak area reproducibility approximately 2-fold, to final RSD values of 2.2-4.7% (n = 900). In contrast (to previous work), Cs as a traditional ISTD resulted in final RSDs of 2.5-8.8%, while the traditional Li ISTD performed poorly with RSDs of 6.3-14.2%. These findings suggest integrated ISTDs are a viable method to improve the precision of disposable MCE devices-giving matched or superior results to the traditional method in this study while neither increasing system cost nor complexity.
Low Gestational Weight Gain Skews Human Sex Ratios towards Females (2014)

My data indicate that human sex ratios change in response to resource availability via sex-specific fetal loss, and that a pivotal time for influences on male survival is early in fetal development, at 6 months of gestation.
Observation of strong magneto plasmonic nonlinearity in bilayer graphene discs (2021)

Abstract Graphene patterned into plasmonic structures like ribbons or discs strongly increases the linear and nonlinear optical interaction at resonance. The nonlinear optical response is governed by hot carriers, leading to a red-shift of the plasmon frequency. In magnetic fields, the plasmon hybridizes with the cyclotron resonance, resulting in a splitting of the plasmonic absorption into two branches. Here we present how this splitting can be exploited to tune the nonlinear optical response of graphene discs. In the absence of a magnetic field, a strong pump-induced increase in on-resonant transmission can be observed, but fields in the range of 3 T can change the characteristics completely, leading to an inverted nonlinearity. A two temperature model is provided that describes the observed behavior well.
Data Supplement from Association Studies of Fcγ Receptor Polymorphisms with Outcome in HER2&lt;sup&gt;+&lt;/sup&gt; Breast Cancer Patients Treated with Trastuzumab in NCCTG (Alliance) Trial N9831 (2023)

&lt;p&gt;Supplementary Table S1. Patient characteristics genotyped cohort vs non-genotyped cohort. Supplementary Table S2. Patient characteristics according to FCGR3A genotype. Supplementary Table S3. Patient characteristics according to FCGR2A genotype. Supplementary Table S4. Patient characteristics according to FCGR2B genotype. Supplementary Figure S1. DFS was not improved for any genotypic group in the trastuzumab-containing regimens.&lt;/p&gt;
HLA‐B38 and clozapine‐induced agranulocytosis in Israeli Jewish schizophrenic patients (1998)

To further substantiate reports of an association between the major histocompatibility complex subtypes and clozapine-induced agranulocytosis, HLA typing was performed in 61 Jewish Israeli schizophrenic patients, in 11 of whom agranulocytosis developed following clozapine treatment and in 50 (controls) of whom it did not. Of the 11 agranulocytosis patients, seven (63%) were of Ashkenazi origin and four (37%) of Sephardi origin. There was no difference in ethnic origin between the arganulocytosis and non-agranulocytosis groups (chi 2 = 2.4, d.f. = 1, P = 0.11), although the agranulocytosis patients had a higher frequency of the HLA B38 antigen (8/11 or 72% vs. 6/50 or 12%; chi 2 = 18.7, d.f. = 1, P < 0.001). These results suggest that major histocompatibility complex gene products could be involved in clozapine-mediated haematological complications.
Toward an effective and reliable representation of solvent effects in the study of biochemical systems (1999)

New computational strategies for the representation of solvent effects in the study of biological macromolecules are examined, in which the polarizable continuum model (PCM) is coupled to a classical representation of the solute. Both energies and analytical gradients can be computed at this level, taking into account polarization effects. A number of improvements of the standard algorithm were also introduced which significantly improved the scaling of the method for large systems. The reliability of these new procedures was tested for model peptides containing standard and nonstandard amino acid residues. ©1999 John Wiley & Sons, Inc. Int J Quant Chem 73: 219–227, 1999
Appropriate Management of Cutaneous Adverse Events Maximizes Compliance with Sorafenib Treatment: A Single-Center Experience (2012)

Our treatment approach seemed to reduce the incidence and/or severity of AEs, keeping patients in treatment, which is essential for good treatment outcomes.
Modulating amygdala activation to traumatic memories with a single ketamine infusion (2021)

Abstract NMDA receptor antagonists have a vital role in extinction, learning, and reconsolidation processes. During the reconsolidation window, memories are activated into a labile state and can be stored in an altered form. This concept might have significant clinical implications in treating PTSD. Using amygdala activity as a major biomarker of fear response, we tested the potential of a single subanesthetic intravenous infusion of ketamine (NMDA receptor antagonist) to enhance post-retrieval extinction of PTSD trauma memories. Post-extinction, ketamine recipients (vs midazolam) showed a lower amygdala and hippocampus reactivation to trauma memories. Post-retrieval ketamine administration was also associated with decreased connectivity between the amygdala and hippocampus, with no change in amygdala-vmPFC connectivity, which suggests that ketamine may enhance post-retrieval extinction of PTSD trauma memory in humans. These findings demonstrate the capacity to rewrite human traumatic memories and to modulate the fear response for at least 30 days post-extinction.
Identification and characterization of a <i>Streptococcus pyogenes</i> ABC transporter with multiple specificity for metal cations (1999)

Metal ions are crucial trace elements for bacteria infecting the human host. The LraI (lipoprotein receptor-associated antigen I) transporter in Streptococcus spp. belongs to the superfamily of ABC transporters. The transporter consists of a lipoprotein, an ATP-binding protein and a hydrophobic integral membrane protein. Here, we describe a new member of the LraI family in the important human pathogen Streptococcus pyogenes. The system was identified in silico by analysis of the S. pyogenes Genome Sequencing Project. The S. pyogenes operon exhibits an atypical organization compared with equivalents in other Streptococcus spp. The presence and atypical organization of the operon was verified in a number of S. pyogenes strains of different serotypes. Transcriptional analysis of the LraI operon demonstrates a polycistronic transcription attenuated by a stable stem-loop structure, which allows the lipoprotein to be expressed in larger quantities than the other two components. The localization of the native lipoprotein at the bacterial surface was shown by proteolytic digestion of S. pyogenes bacteria and NH2-terminal sequencing of a released lipoprotein fragment. Recombinant lipoprotein was expressed as a GST fusion protein, and studies of molecular interactions with metal radioisotopes demonstrated that the protein has affinity for Zn(II), Fe(III) and Cu(II). Zn(II) and Cu(II) were found to compete for the same binding site, whereas Fe(III) uses a second site. Also, proton-induced X-ray analysis of lipoprotein samples identified iron, copper and zinc. Finally, a mutant strain lacking a functional mtsABC operon was generated and showed reduced uptake of 55Fe and 65Zn compared with the wild-type strain. The operon encoding this novel ABC transporter with multiple specificity for metal cations is designated mtsABC, for metal transporter of Streptococcus.
Enabling high-speed turbo-decoding through concurrent interleaving (2003)

Turbo-codes are among the most advanced channel coding schemes and are already part of the 3rd generation wireless communication standards. Future applications, however, will have a demand for higher throughput than the currently targeted 2 Mbit/s, leading to a need for highly parallelized architectures for turbo-decoding. Those where until now nearly infeasible because the component decoders are separated by interleavers, which form a bottleneck between them. This paper presents for the first time architectures that perform concurrent instead of sequential interleaving, thus widening the interleaver bottleneck and enabling parallelized high-speed turbo-decoders. As no limitations on the interleaver design are implied, standard compliant turbo-decoders for high throughput are now feasible. Optimizations for high degrees of parallelization are derived, applied, and validated using our simulated and synthesized register transfer level model. Thus, a whole design space is provided instead of just a single architecture.
185 Baricitinib-associated changes in type I interferon gene signature during a 24-week phase 2 clinical SLE trial (2019)

<h3>Background</h3> In the phase 2 study JAHH (NCT02708095), treatment with baricitinib, an oral selective Janus kinase 1/2 inhibitor approved for the treatment of rheumatoid arthritis, resulted in significant improvements in patients with active SLE receiving standard background therapy compared with placebo.<sup>1</sup> Expression of type I-associated interferon (IFN) responsive genes (IRGs) is elevated in patients with SLE.<sup>2</sup> We developed a robust quantitative assay to measure changes in the IFN signature, and examined the relationship between the IFN signature and measures of clinical outcome. <h3>Methods</h3> 314 patients were randomized 1:1:1 to receive placebo, baricitinib 2- or 4 mg once daily for 24 weeks in study JAHH. Total RNA isolated from whole blood was analyzed using a multiplex assay panel of 6 IRGs at baseline, and Weeks 2, 12, and 24. The assay was developed and optimized using RNA samples from 1760 patients with SLE enrolled in phase 3 trials of tabalumab (an anti-B cell activating factor monoclonal antibody),(2) along with healthy controls. The IFN signature assay produced a bimodal distribution. <h3>Results</h3> 70% of patients had an elevated IFN signature at baseline. Baricitinib significantly reduced the IFN signature by Week 24 compared with placebo (2 mg:−20%, 4 mg:−24%, p0.05), with decreases observed as early as Week 2. In patients who had a high IFN signature at baseline, baricitinib 4 mg significantly reduced the IFN signature at Weeks 12 (-24%) and 24 (-23%) compared with placebo (p0.01); decreases were also observed at Weeks 12 and 24 with baricitinib 2 mg, but the difference from placebo was not statistically significant. Baricitinib 4 mg treatment resulted in significant clinical improvement in the resolution of arthritis or rash determined by the SLEDAI-2K.<sup>1</sup> However, the effect of baricitinib on IFN signature reduction (change from baseline and absolute baseline value) did not correlate with SLEDAI-2K-defined clinical improvement at Week 12 or 24. <h3>Conclusions</h3> A dose-dependent decrease in the IFN signature was observed in baricitinib-treated patients with SLE. Baricitinib treatment resulted in clinical improvement across various measures of SLE disease activity.<sup>1</sup> Response was observed with baricitinib regardless of the change in the IFN gene signature. These data suggest that the clinical improvement observed in baricitinib-treated patients with SLE may be the result of baricitinib-mediated effects on multiple cytokine pathways that may include, but are not limited to, IFN signaling. Ongoing studies using gene arrays are now surveying global immune pathways to better characterize the mechanism of action of baricitinib in SLE. <h3>Funding Source(s):</h3> Eli Lilly and Company <h3>References</h3> Wallace, D. <i>et al</i>. DOI:10.1136/annrheumdis-2018-eular.1918 Hoffman,W. <i>et al. Arthritis Rheumatol</i> 2017;69:643–654.
The Effect of Tryptophan Depletion on Alcohol Self‐Administration in Non‐Treatment‐Seeking Alcoholic Individuals (2002)

These data question the dependence of alcohol self-administration on the ongoing synthesis of serotonin.
Vapor–Liquid Equilibria of Glycerol, 1,3-Propanediol, Glycerol + Water, and Glycerol + 1,3-Propanediol (2012)

Vapor–liquid equilibria of two compounds, glycerol (or 1,2,3-propanetriol) and 1,3-propanediol, and two mixtures, glycerol + water and glycerol + 1,3-propanediol, were determined using a static apparatus. The obtained pressure values range from 6 Pa to 45 kPa for the compounds and from (32 to 163) kPa for the mixtures. From the temperature dependence of the vapor pressures, the molar enthalpies of vaporization at the mean temperature of the experimental range were derived from the Clausius–Clapeyron equation. From these results the standard enthalpies of vaporization at T = 298.15 K were calculated. The experimental data of the mixtures were correlated using the nonrandom two-liquid (NRTL) model.
Patient-Specific Immune States Before Surgery Are Strong Correlates of Surgical Recovery (2016)

(Abstracted from Anesthesiology, 123:1241–1255, 2015) It is thought that a patient's immune state before surgery could predict speed of recovery from fatigue, pain, and functional impairment. Risk-stratifying these patients based on their predicted recovery profile could enable patient-tailored, cost-conscious approaches to perioperative care.
Semantically improved genome-wide prediction of Gene Ontology annotations (2011)

Genomic annotations describing structural and functional features of genes and gene products through controlled terminologies and ontologies are extremely valuable, especially for computational analyses aimed at inferring new biomedical knowledge, which rely on available annotations. Yet, they are incomplete, especially for recently studied genomes, and only some of available annotations represent highly reliable human curated information. In order to help and speedup the time-consuming curation process and improve available annotations, computational methods able to provide prioritized lists of predicted annotations are paramount. Starting from a previous work on automatic prediction of Gene Ontology annotations based on singular value decomposition (SVD) of gene-to-term annotation matrix, here we propose a novel prediction algorithm that incorporates gene clustering based on gene functional similarity computed on Gene Ontology annotations. We tested both prediction methods performing k-fold cross-validation on two organism genomes, Saccharomyces cerevisiae (SGD) and Drosophila melanogaster (FlyBase). Results demonstrate effectiveness of our approach.
Evaluation of yield and maintenance coefficients, expressed in carbon units, forPseudomonas fluorescens andP. aeruginosa (1978)

The maximum cell yield (YMc - g biomass carbon per gram substrate carbon) and the rate of maintenance metabolism (mc - g substrate carbon/g biomass carbon per hour) have been determined for substrate limited continuous cultures of Pseudomonas fluorescens and P. aeruginosa. The metabolism of the organic substrates was monitored by measuring the COD-removal1) rates at different dilution rates. The advantages of expressing yield and maintenance coefficients in carbon units is discussed.