gebhart/patrepeval huggingface dataset:
Stereoselectivity in the binding of the bis(acetylacetonato)(nitro)cobalt(III) moiety to purines and pyrimidines and their nucleosides, interligand interactions in stereoselectivity, and the molecular and crystal structure of the bis(acetylacetonato)(nitro)(deoxyadenosine)cobalt(III) complex (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereoselectivity in the binding of the bis(acetylacetonato)(nitro)cobalt(III) moiety to purines and pyrimidines and their nucleosides, interligand interactions in stereoselectivity, and the molecular and crystal structure of the bis(acetylacetonato)(nitro)(deoxyadenosine)cobalt(III) complexTheophilus Sorrell, Leon A. Epps, Thomas J. Kistenmacher, and Luigi G. MarzilliCite this: J. Am. Chem. Soc. 1977, 99, 7, 2173–2179Publication Date (Print):March 1, 1977Publication History Published online1 May 2002Published inissue 1 March 1977https://pubs.acs.org/doi/10.1021/ja00449a025https://doi.org/10.1021/ja00449a025research-articleACS PublicationsRequest reuse permissionsArticle Views186Altmetric-Citations39LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Experimental verification of textured mechanical seal designed using multi-objective optimization (2019)

Purpose This study aims to simultaneously enhance the load-carrying capacity and control the leakage rate of mechanical seals by optimizing the texture shape. Design/methodology/approach A multi-objective optimization approach is implemented to determine the optimal “free-form” textures and optimal circular dimples. Experiments are conducted to validate the simulation results. Findings The experimental coefficient of friction (COF) and leakage rate are in good agreement with the calculated results. In addition, the optimal “free-form” texture shows a lower COF and a lower leakage in most cases. Originality/value This work provides a method to optimize the surface texture for a better combination performance of mechanical seals.
SELF-ADAPTATION IN AUTOMOTIVE EMBEDDED SYSTEMS USING A MULTI-LAYERED CONTROL APPROACH (2011)

In this work, we present an approach for self-adaptation in automotive embedded systems using a hierarchical, multi-layered control approach.We model automotive systems as a set of constraints and define a hierarchy of control loops based on different criteria.Adaptations are performed at first locally on a lower layer of the architecture.If this fails due to the restricted scope of the control cycle, the next higher layer is in charge of finding a suitable adaptation.We compare different options regarding responsibility split in multi-layered control and a version with centralized control option, in a self-healing scenario with a setup adopted from automotive in-vehicle networks.We show that a multi-layer control architecture has clear performance benefits over a central control, even though all layers work on the same set of constraints.Furthermore, we show that a responsibility split w.r.t.network topology is preferable over a functional split.
Abstract 11: The Utility of Causative Classification System: Correlation between Causative and Phenotypic Stroke Subtypes (2012)

Background: Causative Classification of Stroke (CCS) system is a novel, web-based, and fully-computerized algorithm that integrates clinical, diagnostic, and etiologic stroke characteristics in an evidence-based manner (available at http://ccs.mgh.harvard.edu ) and provides in a given patient both phenotypic subtypes where abnormal evaluation findings are simply organized in major etiologic categories and causative subtypes where abnormal evaluation findings are filtered through a decision making process to identify the most likely cause of stroke. In this study, we sought to identify the concordance between phenotypic and causative CCS subtypes in the NINDS Stroke Genetics Network (SiGN). Methods: A total of 24 adjudicators from 15 US and European sites certified in CCS retrospectively determined CCS subtypes through chart review in 7134 patients. The CCS software provided causative subtypes in 3 confidence levels as “evident”, “probable” or “possible” based on the weight of causal evidence. We estimated how often CCS classified a given major abnormal evaluation finding as the causative stroke mechanism. Results: CCS assigned 55% of patients with the phenotype of moderate-to-severe atherosclerotic stenosis into the causative category of “evident large artery atherosclerosis”. Likewise, 50% of patients with a major cardiac source (such as atrial fibrillation) were classified into “evident cardio-aortic embolism”, and 74% of those with imaging evidence of a typical lacunar infarct into “evident small artery occlusion”. In 20% to 30% of patients, phenotypic and causative categories were the same but the causative subtype was assigned with a lower level of confidence. Six to 20% of patients with a given phenotypic feature were classified into a different causative category. Failure to investigate for other subtypes in the presence of a positive test finding and the presence of multiple competing etiologies were key contributors to the observed disconcordance between phenotypic and causative subtypes. Conclusions: Our findings show that the presence of a major abnormality in stroke evaluation does not necessarily mean that it is always the cause. The ability of CCS system to discriminate between phenotypic and causative characteristics of stroke etiology provides the opportunity to refine stroke phenotypes for use in research studies.
On the distribution of colors in natural images (2010)

When analyzing the RGB distribution of colors in natural images we notice that they are organized into spatial structures. This observation is not new, quoting Omer and Werman in [5]: “... when looking at the RGB histogram of
Transverse susceptibility of nickel thin films with uniaxial anisotropy (2021)

A finite temperature Stoner-Wohlfarth model has been used to calculate the transverse susceptibility of an ensemble of ferromagnetic particles with distributed anisotropy. The simulated transverse susceptibility is in excellent agreement with data acquired from thin film samples of elemental nickel, deposited on 128° Y-cut LiNb0<sub>3</sub>. A strong, well-defined, uniaxial anisotropy is induced in the nickel film by low temperature annealing. Three peaks in the transverse susceptibility are observed in both the measured and simulated data when the applied field is misaligned with the hard axis by a few degrees. Two broad, reversible peaks occur when the applied field is equal to the anisotropy field. A single, sharp irreversible peak occurs when the absolute value of the applied field is less than the anisotropy field, and is associated with a metastable magnetic state. The irreversible peak disappears when the applied field is well aligned with the hard axis. The observed transverse susceptibility is consistent with the theoretical predictions of Aharoni et al. and is therefore consistent with the Stoner-Wohlfarth model.
Advantages of BARC and photoresist matching for 193-nm photosensitive BARC applications (2010)

As the semiconductor industry approaches smaller and smaller features, applications that previously used top antireflective coatings have now begun using developer-soluble bottom anti-reflective coatings (BARCs). However, there are several drawbacks to a wholly developer-soluble system, mainly because many of these systems exhibit isotropic development, which makes through-pitch and topography performance unsatisfactory. To solve this problem, we have developed several photosensitive BARC (PS BARC) systems that achieve anisotropic development. One issue with the PS BARC, as with traditional dry BARCs, is resist compatibility. This effect is compounded with the photosensitive nature of our materials. The acid diffusion and quenching nature of the resists has been shown to have a significant effect on the performance of the acid-sensitive PS BARC. Some resists contain a highly diffusive acid that travels to the PS BARC during the post-exposure bake and aids in clearance. Others show the opposite effect, and the same PS BARC formulation is not able to clear completely. To address the lack of compatibility and to further improve the PS BARC, we have developed a solution that properly matches PS BARC and photoresist performance.
Couplage entre une membrane à cristaux photoniques en matériaux III-V et une fibre micro-lentillée : simulations et mesures (2011)

session orale JNOG_2 "Nanophotonique"
Highly Effective Polymerization of Acrylate Catalyzed by a “Constrained Geometry” Titanium Complex/B(C<sub>6</sub>F<sub>5</sub>)<sub>3</sub> System (2007)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTHighly Effective Polymerization of Acrylate Catalyzed by a "Constrained Geometry" Titanium Complex/B(C6F5)3 SystemBing Lian, Christophe M. Thomas, Christophe Navarro, and Jean-François CarpentierView Author Information Catalyse et Organométalliques, UMR 6226, University of Rennes 1, 35042 Rennes Cedex, France, and Arkema, Lacq Research Center, Po Box 34, 64170 Lacq, France Cite this: Macromolecules 2007, 40, 7, 2293–2294Publication Date (Web):March 3, 2007Publication History Received23 February 2007Published online3 March 2007Published inissue 1 April 2007https://pubs.acs.org/doi/10.1021/ma070465ahttps://doi.org/10.1021/ma070465arapid-communicationACS PublicationsCopyright © 2007 American Chemical SocietyRequest reuse permissionsArticle Views362Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Copolymerization,Copolymers,Monomers,Organic compounds,Polymerization Get e-Alerts
Effect of N-Acetylcysteine on the Matrix Metalloproteinases and Their Inhibitors in Carbon Tetrachloride-Induced Hepatotoxicity (2009)

Matrix metalloproteinases (MMPs) are a group of zinc proteases that serve the function of breaking down extracellular matrix (ECM). The present study evaluated the role of N-acetylcysteine (NAC) on the increased deposition of ECM in hepatic and glomerular fibrosis caused by carbon tetrachloride (CCl₄). The activity of MMPs increased and the levels of tissue inhibitors of metalloproteinases 1 and 2 (TIMP-1 and TIMP-2) decreased in the liver and kidney of CCl₄-treated rats. Rats treated with CCl₄ and NAC showed increased activities of MMPs and decreased levels of TIMP-1 and TIMP-2 in the liver and kidney. Treatment with NAC resulted in the effective degradation of ECM due to an increase in the activities of MMPs and a decrease in the levels of TIMPs.
Morphological and Structural Responses of Albizia lebbeck to Different Lead and Nickel Stress Levels (2023)

Lead (Pb) and nickel (Ni) are serious soil pollutants that adversely affect plant growth and development and need to be removed through phytoremediation. The present study aimed to assess the morphological indices of Albizia lebbeck (L.) (Benth.) in relation to anatomical modifications for survival under both Pb and Ni stress. The seedlings of A. lebbeck were established and then subjected to four different concentrations, viz. 0 mM, 25 mM, 50 mM and 75 mM, of Pb and Ni for 14 days in two phases. Morphological traits such as shoot length (70.93%), fresh weight (79.27%), dry weight (83.9%), number of root hairs (65.7%), number of leaves per plant (67.4%) and number of leaflets per plant greatly reduced under Pb or Ni stress. Surprisingly, root length increased rather than decreased with the increase in Pb or Ni concentrations, along with an increase in leaflet width, leaflet length and leaflet area. Moreover, root cortical cell area, metaxylem area and phloem area decreased at 75 mM of Pb and Ni while epidermal thickness and cell area increased. Stem epidermal thickness, cell area and phloem area significantly decreased with the consistent increase in metaxylem area and cortical region thickness under both Pb and Ni stress. Leaf anatomical traits such as midrib thickness, abaxial epidermal thickness and stomatal density and adaxial epidermal thickness and stomatal area significantly increased with increasing Pb or Ni stress. Correlation analysis revealed close relations among morphological and anatomical traits (such as root length with cortical region thickness) for better plant survival under Pb or Ni stress, and a PCA-biplot further verified these correlation analyses. Cluster analyses demonstrated the associations among the morphological and anatomical traits based on different stress levels. Furthermore, we found that the longer exposure (from phase 1 to phase 2) of heavy metals stress is more dangerous for plant survival and can ultimately lead to plant death. Moreover, our results also confirmed that Ni is more harmful or dangerous to plants than Pb at high and moderate concentrations. The anatomical modifications ensured the survival of A. lebbeck in extreme heavy metals stress and therefore unlocked its potential to be used as a natural source of phytoremediation. We also recommend that the genetic potential of A. lebbeck associated with its survival under heavy metal stress be investigated.
Supplementary Figure 5 from Neutralization of BCL-2/X&lt;sub&gt;L&lt;/sub&gt; Enhances the Cytotoxicity of T-DM1 &lt;i&gt;In Vivo&lt;/i&gt; (2023)

&lt;p&gt;p63 MCL-1 HER3 post-treatment.&lt;/p&gt;
Comprehensive Evaluation of Ocular Toxicity of Topical Levofloxacin in Rabbit and Primate Models (2004)

Levofloxacin, the L‐isomer of ofloxacin and a potent quinolone with a broad spectrum of antibacterial activity, was evaluated in a series of toxicology studies including acute and chronic dosing in rabbits and primates with intact and injured eyes. No evidence of ocular toxicity was observed in rabbits with intact eyes that were topically instilled with levofloxacin ophthalmic solutions under various treatment regimens, including multiple dosing (four to six times daily) for up to 26 weeks at levofloxacin concentrations from 0.3% to 3%. When rabbits were repetitively instilled (10 times at 30 minute intervals) with 0.3%, 1%, or 3% levofloxacin ophthalmic solutions over a single day, they exhibited no increase in ocular irritation scores, whereas dosing with 10% and 25% levofloxacin produced dose‐dependent increases in ocular discharge, conjunctival injection and edema, corneal edema/fluorescein staining, iridic congestion, and behavioral abnormalities. Healing of 7.5 mm diameter epithelial wounds in rabbit eyes was not delayed by dosing four times daily (QID) with 0.5% or 1.5% levofloxacin in four different vehicles, with complete healing after 48 hours. The QID dosing with 3% or 6% levofloxacin retarded healing at 24 hours, but healing was complete in eyes treated with 3% levofloxacin by 72 hours after injury, and nearly complete in eyes treated with 6% levofloxacin by 96 hours. Using a similar model in primates, QID treatment with 1.5% levofloxacin produced no delay in healing of epithelial wounds or increased corneal thickness compared to glycerin vehicle, while QID treatment with 3% levofloxacin delayed healing at 24 and 48 hours after injury and increased corneal thickness for 11 days. Histological evaluation of the eyes confirmed that there was no detrimental effect to the corneal endothelium as a result of treatment with 1.5% levofloxacin. In conclusion, the results of these studies support the ocular safety of concentrations of levofloxacin up to 1.5% when administered topically to the intact or wounded eye.
Lung cancer screening in COPD patients. (2018)

<b>Introduction:</b> Lung screening is a current topic of discussion. One of the variables needed to determine whether to screen or not, is the screening population. <b>Methods:</b> Patients 40 years and older with COPD categories B to D, current or ex-smokers with smoking history of 10 pack years or more and at least one exacerbation in the previous year were recruited for the histological, cellular and molecular investigation of steroid responsiveness in COPD study – the HISTORIC study. Patients with rapid fatal disease, a pulmonary condition other than COPD, severe immune suppression or use of oral steroids &gt;10mg per day were excluded from the study. This is an ongoing study. All patients underwent a computer tomography (CT) scan as part of their baseline measurements. <b>Results:</b> 63 patients of 73 screened patients were included into the study from May 2017 to December 2017. Seventeen patients, from 19 patients diagnosed with nodules, required follow-up CT-scans within 12 months. Since the start of the study, 4 (6.3%) of the 63 patients were diagnosed with lung cancer based on the CT-scan performed in the study. One of the five patients had a history of cancer. All four patients were diagnosed with early-stage cancer, T1a (1), T1b (3), N0 (3) and N1 (1). These patients were on average 72.3±2.2 years old, had been diagnosed with COPD on average 80.0±30.5 months before inclusion in the study, and had an average Charlson comorbidity score of 3.3±2.6. All four patients were past-smokers with an average pack year of 45.0±5.8. The last CT-scan performed in these four patients was on average 18.3±28.3 months before inclusion into the study. <b>Conclusion:</b> Screening of COPD patients with CT-scan may result in early detection of lung cancer.
Quantification of Dual-task Performance in Healthy Young Adults Suitable for Military Use (2021)

Based on the performance of healthy young adults, the number discrimination task may be optimal for detecting subtle changes in dual-task performance. The detected differences found between the eyes-open and eyes-closed conditions provide discriminatory value and insight into the reliance of vision of postural stability performance. While dual-task cognitive performance was not observed in this healthy population, individuals with mTBI may exhibit decreased dual-task performance. The independent evaluation of cognitive and motor function under dual-task conditions has the potential to transform the management and treatment of mTBI.
Ring-Opening Rearrangements of 2-(Benzotriazol-1-yl) Enamines and a Novel Synthesis of 2,4-Diarylquinazoline (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRing-Opening Rearrangements of 2-(Benzotriazol-1-yl) Enamines and a Novel Synthesis of 2,4-DiarylquinazolineAlan R. Katritzky, Baozhen Yang, Jinlong Jiang, and Peter J. SteelCite this: J. Org. Chem. 1995, 60, 1, 246–249Publication Date (Print):January 1, 1995Publication History Published online1 May 2002Published inissue 1 January 1995https://pubs.acs.org/doi/10.1021/jo00106a041https://doi.org/10.1021/jo00106a041research-articleACS PublicationsRequest reuse permissionsArticle Views263Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Asymmetric synthesis with .alpha.,.beta.-bis[(methoxymethyl)oxy] ketones. Enantioselective total synthesis of natural (+)-indolizidine 195B (bicyclic gephyrotoxin 195B) and (-)-pinidine and their enantiomers from a common chiral synthon (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAsymmetric synthesis with .alpha.,.beta.-bis[(methoxymethyl)oxy] ketones. Enantioselective total synthesis of natural (+)-indolizidine 195B (bicyclic gephyrotoxin 195B) and (-)-pinidine and their enantiomers from a common chiral synthonNaoki Yamazaki and Chihiro KibayashiCite this: J. Am. Chem. Soc. 1989, 111, 4, 1396–1408Publication Date (Print):February 1, 1989Publication History Published online1 May 2002Published inissue 1 February 1989https://pubs.acs.org/doi/10.1021/ja00186a038https://doi.org/10.1021/ja00186a038research-articleACS PublicationsRequest reuse permissionsArticle Views2003Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts