gebhart/patrepeval huggingface dataset:
Modulation of thyroglobulin messenger RNA level by thyrotropin in cultured thyroid cells (1979)

To examine the influence of thyrotropin (TSH) on the thyroglobulin (Tgb) mRNA content, the latter was evaluated in the cytoplasm of hog thyroid cells cultured in the absence (control cells) or presence of TSH. The Tgb mRNA levels were determined by, (i) kinetics of hybridization to sheep Tgb cDNA, (ii) capacity of coding for peptides immunologically related to Tgb in reticulocyte lysate. In cells cultured for 4 days in the absence of TSH, the content of Tgb mRNA sequences decreased to 30% of its initial value and the messenger activity to 15%. Conversely, TSH maintained the initial Tgb mRNA level in cells cultured in its presence, and TSH concentrations 50 micronU/ml or 5 mU/ml gave identical results. At each period tested poly (A) content was the same in TSH-treated and control cells. When TSH was added to media after 4 or 8 days culture without TSH, the Tgb mRNA level was partially restored. These results suggest that TSH exerts a positive control on Tgb gene expression through modulation of Tgb mRNA content of thyroid cells.
A Simple Procedure for Isolation of Tumor-Associated Antigens by Affinity Chromatography Using Fucose-Specific<i>Aleuria aurantia</i>Lectin (1990)

An affinity column containing L-fucose specific Aleuria aurantia lectin was used for the efficient separation of tumor-associated antigens. Five of six glycoconjugates antigens tested, carcinoembryonic antigen (CEA), CA19-9, sialyl Lewis X-i, DU-PAN-2 and CA125, bound to the affinity gel and eluted in high yield with 20 mM L-fucose, but alpha-fetoprotein, which is known to contain fucose in the carbohydrate chain, passed through the column. This column was also proved to be useful for group separation of CA19-9, sialyl Lewis X-i and Leb antigens from a serum sample with gastric cancer.
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Organocatalytic One‐Pot Sequential 1,4‐Addition/Dearomative‐Fluorination Transformation. (2013)

Abstract This reaction yields products with adjacent tertiary and quarternary stereocenters in good yields with high diastereo‐ and enantioselectivities.
Adaptive Geobodies: Data Driven, Interpreter Controlled Geobody Delineation of Channel and Carbonate Features (2011)

The accurate extraction of 3D geobodies that represent geological features is a fundamental aspect of seismic interpretation. Currently this can be achieved using volumetric threshold based extraction techniques, or autotracking / region growing from a seed-point and tracked on a threshold limit or range. Advances in colour blending techniques (such as volumetric RGB) have allowed the extraction of geobodies utilising three volume channels. This has enabled greater control over the extraction process but can still be unreliable in the presence of noise or variations in the expression of a geological feature. To address this issue we have developed an innovative technique which allows geobodies to be grown on single or multi attribute data that is many times more reliable than existing geobody delineation methods whilst still being extremely simple to apply. The technique is based on a sophisticated analysis of local data statistics that is robust to changes in expression and noise. This data driven technology is combined with intuitive manual manipulation tools that enables on the fly 3D editing of geobodies in data areas where data driven techniques alone are not sufficient. Confidence values computed at every point on the geobody surface are displayed to provide direct visual feedback to the interpreter on how well the geobody is fitting to the data, which in turn helps the interpreter edit the geobody more accurately. This unique technique (patent pending) has enabled accurate extraction of geobodies in areas where all other commercially available techniques have failed. This includes braided channel systems and interconnected karst systems. In this paper we will present a selection of results from different geological settings which illustrate the interpretive advantage of this technique.
Commentary on This Article from Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase Ib and Pharmacokinetic Study (2023)

Commentary on This Article from Chemoprevention of Head and Neck Cancer with Celecoxib and Erlotinib: Results of a Phase Ib and Pharmacokinetic Study
Revisited crystal symmetry of the high-spin form of the iron(II) spin-crossover complex dicyano[2,13-dimethyl-6,9-dioxa-3,12,18-triazabicyclo[12.3.1]octadeca-1(18),2,12,14,16-pentaene]iron(II) monohydrate (2004)

The title iron(II) complex, [Fe(CN)(2)(C(15)H(23)N(3)O(2))].H(2)O, is of interest to the spin-crossover community because of its unusual temperature-dependent magnetic behaviour as well as its relatively high relaxation temperature for the light-induced spin-crossover phenomenon. Structural modifications are strongly suspected to cause the unusual thermal spin-crossover features. Recently, the high-spin crystal structure has been reported but with an inadequate space group. In the present paper, the crystal structure is corrected by a new investigation, and some consequences for the structure-property relationships of this complex are discussed. The Fe(II) ion is seven-coordinate and lies on a twofold axis.
Caudal epidurals: the whoosh test (1998)

Caudal epidural injection is a simple procedure that carries a low risk of complications. The whoosh test (injection of air into the caudal epidural space with simultaneous auscultation over the thoracolumbar spine) has been recommended as an aid to correct needle placement. A 1-year prospective study, using fluoroscopic imaging to identify needle position, was conducted to compare the sensitivity and specificity of the whoosh test with that of clinical impression alone in assessing correct needle placement in the caudal space. Of 131 patients studied, correct needle placement was achieved in 121 on the first attempt (92%). Clinical impression alone had a sensitivity of 94% and a specificity of 20%. The whoosh test had a sensitivity of 80% and a specificity of 60%. The whoosh test is superior to clinical judgment in detecting incorrect caudal needle placement.
Human iPSC-Derived Renal Cells Change Their Immunogenic Properties during Maturation: Implications for Regenerative Therapies (2022)

The success of human induced pluripotent stem cell (hiPSC)-based therapy critically depends on understanding and controlling the immunological effects of the hiPSC-derived transplant. While hiPSC-derived cells used for cell therapy are often immature with post-grafting maturation, immunological properties may change, with adverse effects on graft tolerance and control. In the present study, the allogeneic and autologous cellular immunity of hiPSC-derived progenitor and terminally differentiated cells were investigated in vitro. In contrast to allogeneic primary cells, hiPSC-derived early renal progenitors and mature renal epithelial cells are both tolerated not only by autologous but also by allogeneic T cells. These immune-privileged properties result from active immunomodulation and low immune visibility, which decrease during the process of cell maturation. However, autologous and allogeneic natural killer (NK) cell responses are not suppressed by hiPSC-derived renal cells and effectively change NK cell activation status. These findings clearly show a dynamic stage-specific dependency of autologous and allogeneic T and NK cell responses, with consequences for effective cell therapies. The study suggests that hiPSC-derived early progenitors may provide advantageous immune-suppressive properties when applied in cell therapy. The data furthermore indicate a need to suppress NK cell activation in allogeneic as well as autologous settings.
Enhanced <i>In Vivo</i> Airway Gene Transfer via Transient Modification of Host Barrier Properties with a Surface-Active Agent (1998)

Effective adenoviral gene therapy requires efficient viral vector entry into epithelial cells. Injured airway epithelia display enhanced gene transfer, reflecting in part increased vector access to protected cell populations and/or protected basolateral membranes. We tested whether adenoviral gene transfer is enhanced by modification of the epithelial barrier in mouse nasal airways with a nonionic detergent (polidocanol, PDOC). In C57BL/6 mice, 1.6 x 10(9) PFU of Ad5CMV LacZ (AdLacZ) instilled into the right nostril produced negligible gene transfer to the nasal epithelium 2 days after dosing, but significant, dose-dependent increases in gene transfer were achieved by pretreatment with PDOC. Permeation of the electron-dense tracer lanthanum into the intercellular junctions of PDOC (0.1%)-treated murine nasal epithelium, but not into intercellular junctions of vehicle controls, is consistent with PDOC-mediated increases in tight junctional permeability. In CF(-/-) mice, significant gene expression was not detectable after exposure to Ad5CBCFTR alone (1.4 x 10(9) PFU in 20 microl; AdCFTR), but PDOC pretreatment prior to AdCFTR instillation produced functional expression of CFTR (measured as deltaPD) 5 days after instillation. Because the development and testing of lung gene therapy will principally occur in children and adults with airway disease, AdLacZ gene transfer with and without PDOC pretreatment was examined in infected nasal airways. Gene expression was significantly reduced in infected as compared with uninfected airways. We conclude that the use of adjuvant surface-active and/or membrane-perturbing agents, synthetic or naturally derived, may provide a novel approach to enhancing the efficiency of adenoviral gene transfer.
Electrostatically accelerated tin whisker development under x- and\n gamma-rays (2020)

We observed the accelerated tin whisker development under non-destructive\ngamma-ray and x-ray irradiation and determined the characteristic range of\nradiation doses 20-30 KGy, for which that effect becomes significant. We were\nable to change the radiation induced whisker growth by electrically\ndisconnecting some parts of our experimental setup thus demonstrating the\nelectrostatic nature of the accelerated whisker development. The observed\nacceleration factors make the ionizing radiation a potential non-destructive\nand readily implementable accelerated life testing tool.\n
Benchmarks for Grid Flexibility Prediction: Enabling Progress and Machine Learning Applications (2020)

International audience
Effect of added amines on the morphology of multivesiculated polyester particles (2012)

Multivesiculated polyester particles (MVPs) are obtained by reticulation of a double emulsion system formed by a polyester/styrene solution dispersed in an aqueous colloidal solution. During its synthesis, the acid/base reaction between polyester carboxylic end groups and an added amine plays an important role in stabilizing the two emulsion systems (water‐in‐oil and oil‐in‐water). This work studies the influence of diethylenetriamine, aminoethylethanolamine, diethanolamine, and triethanolamine on MVPs' average particle size, vesiculation morphology, dry film opacity, and yellowing. The particular aspects observed for each amine are discussed, allowing identification of the relevant mechanisms taking place in the formation of MVPs. POLYM. ENG. SCI., 53:2261–2269, 2013. © 2012 Society of Plastics Engineers
Electrothermally Tunable Bridge Resonator (2016)

This paper demonstrates experimentally, theoretically, and numerically a wide-range tunability of an in-plane clamped-clamped microbeam, bridge, and resonator compressed by a force due to electrothermal actuation. We demonstrate that a single resonator can be operated at a wide range of frequencies. The microbeam is actuated electrothermally, by passing a DC current through it. We show that when increasing the electrothermal voltage, the compressive stress inside the microbeam increases, which leads eventually to its buckling. Before buckling, the fundamental frequency decreases until it drops to very low values, almost to zero. After buckling, the fundamental frequency increases, which is shown to be as high as twice the original resonance frequency. Analytical results based on the Galerkin discretization of the Euler Bernoulli beam theory are generated and compared to the experimental data and to simulation results of a multi-physics finite-element model. A good agreement is found among all the results.
Molecular Tectonics. Use of Br•••aryl Supramolecular Interactions for the construction of Organized Networks from 9,9’-spirobifluorene in the Crystalline State (2011)

Numerous studies, many based on statistical analyses of structural data from the Cambridge Structural Database (CSD, have highlighted the importance of halogenaryl interactions. Although the exact value of the binding energy is still a subject of debate, it is generally agreed that such interactions can play an important role in crystal packing. For example, previous work by Desiraju and collaborators has shown that Braryl interactions generate characteristic supramolecular motifs, which may be useful for designing molecular solids [2]. With this goal in mind, we set out to use 9,9'spirobifluorene (SBF) or tetrabrominated SBF derivatives as tectons [3] and to see if Braryl interactions can be used to build predictable molecular networks. Several features made the SBF core an attractive candidate for this study: 1) SBF has D 2 d symmetry, is rigid and orients its aromatic rings and their substituents in distinct directions of space; 2) the synthesis of SBF derivatives has been described; and 3) derivatives of SBF tend to crystallize readily, frequently as inclusion complexes, which allows the study of interactions between the network and included guests. In the first part of our work, the two different tetrabromo-SBFs (substituted in the meta and para positions, respectively, relative to the spiro center) were synthesized either by a literature procedure or through a new route. Crystals were grown and the structures were solved. Both structures are close packed, and the molecules are linked together by BrAr interactions and also by BrBr contacts. In the second part of our work, we co-crystallized un-substituted SBF with small brominated guests that orient 1, 2, 3 or 4 atoms of bromine in distinct directions. The structures of four co-crystals were solved, and analysis reveals the following points: 1) There are at most only a few direct interactions (CH) between the SBF units themselves; 2) by engaging in Braryl interactions, the brominated guests play a role of connector between SBF units; iii) in this way, Braryl interactions direct the packing of the crystal structures.
Atomic characterizations of modulation spaces through Gabor-type representations (1989)

Given s G R and 1 < p, q < oo the modulation space Mp g (R m ) can be described as follows, using the Gauss-function go,go(x) '= exp(-x 2 )
Effects of ghrelin administration on decreased growth hormone status in obese animals (2007)

Obesity is characterized by markedly decreased ghrelin and growth hormone (GH) secretion. Ghrelin is a GH-stimulating, stomach-derived peptide that also has orexigenic action. Ghrelin supplement may restore decreased GH secretion in obesity, but it may worsen obesity by its orexigenic action. To reveal effects of ghrelin administration on obese animals, we first examined acute GH and orexigenic responses to ghrelin in three different obese and/or diabetic mouse models: db/db mice, mice on a high-fat diet (HFD mice), and Akita mice for comparison. GH responses to ghrelin were significantly suppressed in db/db, HFD, and Akita mice. Food intake of db/db and Akita mice were basally higher, and further stimulation of food intake by ghrelin was suppressed. Pituitary GH secretagogue receptor mRNA levels in db/db and HFD mice were significantly decreased, which may partly contribute to decreased GH response to ghrelin in these mice. In Akita mice for comparison, decreased hypothalamic GH-releasing hormone (GHRH) mRNA levels may be responsible for decreased GH response, since maximum GH response to ghrelin needs GHRH. When ghrelin was injected into HFD mice with GHRH coadministrated, GH responses to ghrelin were significantly emphasized. HFD mice injected with low-dose ghrelin and GHRH for 10 days did not show weight gain. These results indicate that low-dose ghrelin and GHRH treatment may restore decreased GH secretion in obesity without worsening obesity.
EDITOR'S CORNER (2007)

Methods in Microbiology held at Kansas State University during the 2005 and 2006 Workshops.The Molecular Detection Day started about 10 years ago as a part of the week-long Workshop.During this particular day, many scientists from university, industry and government presented outstanding lectures covering many important topics related to automation, rapid methods, molecular biology and nanotechnology issues.Along with the presentations, industrial experts came to present and demonstrate their latest systems and materials to the participants.The participants had detailed information of each system and observed the actual operation of the units in a large, spacious and functional laboratory at the Kansas State University Veterinary School.It was a very intensive day but a lot was accomplished.
Specific Two-Photon Imaging of Live Cellular and Deep-Tissue Lipid Droplets by Lipophilic AIEgens at Ultralow Concentration (2018)

This document is the Accepted Manuscript version of a Published Work that appeared in final form in&#13;\nChemistry of Materials, copyright © American Chemical Society after peer review and technical editing by the publisher.&#13;\nTo access the final edited and published work see [insert ACS Articles on Request author-directed link to&#13;\nPublished Work, see https://pubs.acs.org/doi/10.1021/acs.chemmater.8b01943.
Sphingosine 1-phosphate signalling (2013)

Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.
Microwave In Organic Synthesis: Myth Or Reality? (2004)

Recent state of the art in microwave mediated organic synthesis is reported. The claimed athermal effect of microwave in speeding-up organic reaction with concomitant improvements of the yields is ...
Changes in Athletic Performance in Children Attending a Secondary School with a Physical Activity Profile (2022)

The longitudinal and multidisciplinary research project Malmö Youth Sport Study measured the sports results achieved by two cohorts of pupils using a variable named ACHIEVE, dividing the pupils into three categories (an elite group competing at the national or international level, a group competing at the district level, and a third group either not competing at all or below district level). This was assessed three and six years after baseline at age 13. An additional hypothetical measure, based on information from the athletes' trainers, predicted the category the pupils were expected to belong to after twelve years (age 25). Social variables related to the ACHIEVE variable are sex, socio-economic position of the parents, ethnicity, completed secondary sports school, sports capital, and quartile of birth. After three years, 28% of the pupils belonged to the elite group and after six years, 26%. Thirty-two and 48%, respectively, had abandoned their elite efforts. The elite group remained fairly stable over time but fewer girls than boys advanced to the elite group. The pupils at the school have a homogenous middle-class background. We found little evidence that socio-economic factors affected ACHIEVE. Nearly all parents had been engaged in sports, either competing or as coaches. On admission to the school, there was a pronounced relative age effect (RAE). This remained after three years as the age was significantly different between the three groups but was reduced after six years. According to the prognosis made by the coaches, the elite group would be considerably smaller when the subjects reached the age of 25. The RAE was again significant in the prognosis. A further follow-up when the subjects are 25 years old will reveal not only what proportion of subjects are actively competing, but also if they are engaged in recreational sports, to what extent the RAE is present, and how accurately coaches can predict success.
Average Sensitivity and Noise Sensitivity of Polynomial Threshold Functions (2014)

We give the first nontrivial upper bounds on the Boolean average sensitivity and noise sensitivity of degree-$d$ polynomial threshold functions (PTFs). Our bound on the Boolean average sensitivity of PTFs represents the first progress toward the resolution of a conjecture of Gotsman and Linial [Combinatorica, 14 (1994), pp. 35--50], which states that the symmetric function slicing the middle $d$ layers of the Boolean hypercube has the highest average sensitivity of all degree-$d$ PTFs. Via the $L_1$ polynomial regression algorithm of Kalai et al. [SIAM J. Comput., 37 (2008), pp. 1777--1805], our bound on Boolean noise sensitivity yields the first polynomial-time agnostic learning algorithm for the broad class of constant-degree PTFs under the uniform distribution. To obtain our bound on the Boolean average sensitivity of PTFs, we generalize the “critical-index” machinery of [R. Servedio, Comput. Complexity, 16 (2007), pp. 180--209] (which in that work applies to halfspaces, i.e., degree-1 PTFs) to general PTFs. Together with the “invariance principle” of [E. Mossel, R. O'Donnell, and K. Oleszkiewicz, Ann. of Math. (2), 171 (2010), pp. 295--341], this allows us to essentially reduce the Boolean setting to the Gaussian setting. The main ingredients used to obtain our bound in the Gaussian setting are tail bounds and anticoncentration bounds on low-degree polynomials in Gaussian random variables [S. Janson, Gaussian Hilbert Spaces, Cambridge University Press, Cambridge, UK, 1997; A. Carbery and J. Wright, Math. Res. Lett., 8 (2001), pp. 233--248]. Our bound on Boolean noise sensitivity is achieved via a simple reduction from upper bounds on average sensitivity of Boolean PTFs to corresponding bounds on noise sensitivity.
Hedgehog signaling controls fibroblast activation and tissue fibrosis in systemic sclerosis (2012)

We demonstrated that the hedgehog pathway is activated in patients with SSc. Hedgehog signaling potently stimulates the release of collagen and myofibroblast differentiation in vitro and is sufficient to induce fibrosis in vivo. These findings identify the hedgehog cascade as a profibrotic pathway in SSc.