gebhart/patrepeval huggingface dataset:
Theory of χ<sup>(2)</sup>-microresonator-based frequency conversion (2021)

Microresonator-based platforms with ${\chi ^{(2)}}$ nonlinearities have the potential to perform frequency conversion at high efficiencies and ultralow powers with small footprints. The standard doctrine for achieving high conversion efficiency in cavity-based devices requires "perfect matching," that is, zero phase mismatch while all relevant frequencies are precisely at a cavity resonance, which is difficult to achieve in integrated platforms due to fabrication errors and limited tunabilities. In this Letter, we show that the violation of perfect matching does not necessitate a reduction in conversion efficiency. On the contrary, in many cases, mismatches should be intentionally introduced to improve the efficiency or tunability of conversion. We identify the universal conditions for maximizing the efficiency of cavity-based frequency conversion and show a straightforward approach to fully compensate for parasitic processes such as thermorefractive and photorefractive effects that, typically, can limit the conversion efficiency. We also show the design criteria that make these high-efficiency states stable against nonlinearity-induced instabilities.
Relationships with Static Logics (2000)

This chapter contains sections titled: The Uninterpreted Level, The Interpreted Level, Bibliographical Notes
Figure S2 from Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity (2023)

&lt;p&gt;Figure S2 shows the species cross-reactivity of 7A5 antibody&lt;/p&gt;
Synthesis and Characterization of Enantiomerically Pure Menthylamines and Their Isocyanates (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Will personalized drugs for cardiovascular disease become an option? – Defining ‘Evidence-based personalized medicine’ for its implementation and future use (2015)

It is generally accepted that the implementation of pharmacogenomics and, more broadly, personalized medicine will have to be 'evidence-based'. However, there is a lack of consensus on the level of evidence required to justify the use of pharmacogenomic testing in clinical practice. In the cardiovascular field, this lack of agreement has led to somewhat contradicting recommendations by different organizations regarding the clinical utility and use of pharmacogenomic tests or information. Here, we argue that randomized, controlled trials are paramount in order to enable and accelerate the widespread implementation of pharmacogenomics, not only to demonstrate the clinical efficacy and cost-effectiveness of such tests, but because such level of evidence is required to support the considerable changes associated with the implantation of pharmacogenomics in clinical practice.
Direct Observation of Polymer Sheathing in Carbon Nanotube−Polycarbonate Composites (2003)

A series of observations of polymer sheathing in multiwalled carbon nanotube (MWCNT)−polycarbonate composites are presented. This sheathing was observed in images of the composite fracture surface and is consistent with diameter distributions of the as-received and embedded MWCNTs. A novel nanomanipulation experiment, where the sheathing balls up when contacted by an AFM tip, confirms this phenomenon. This sheathing layer is direct evidence of substantial MWCNT−polymer interaction and will influence the mechanical properties of MWCNT-polymer composites.
Amelioration by Quinapril of Myocardial Infarction Induced by Coronary Occlusion/Reperfusion in a Rabbit Model of Atherosclerosis (1999)

Chronic quinapril treatment ameliorated the severity of myocardial injury produced by coronary occlusion/reperfusion in cholesterol-fed rabbits, possibly because of reversal of the enhanced interaction between leukocytes and endothelium in the ischemic myocardium via a bradykinin-related pathway.
Tibialis anterior skeletal muscle alterations following immobilization in the rat is associated with sustained activation of the proteasome dependent proteolysis and the mitochondria associated apoptosis during the early stages of recovery (2011)

International audience
Interruption of the CXCL13/CXCR5 Chemokine Axis Enhances Plasma IgM Levels and Attenuates Atherosclerosis Development (2019)

Atherosclerosis is a chronic inflammatory disease typified by the subendothelial accumulation of lipids and inflammatory cells.[1] With disease progression, lesions can develop into fibroatheromatous lesions, prone to rupture causing thrombus formation, which is the main cause of cardiovascular complications like myocardial infarction and stroke.[2] Chemokines play an important role in the development and progression of atherosclerosis.[3] In the past decade, multiple other functions, beyond the classical chemotaxis, have been reported like cell survival and angiogenesis, and platelet activation.[4] [5] [6] [7]
Excitation correlation spectroscopy of semiconductors in the mid-infrared (2004)

We describe the extension of excitation correlation to the mid-infrared. This novel technique provides a convenient alternative to more complicated optical pump-probe and time-resolved photoluminescence approaches for investigating electron-hole recombination and radiative processes in semiconductors. Excitation correlation is used to determine the recombination coefficients for a GaInSb/InAs superlattice. Full-text article is not available.
Sum Spectral Efficiency Maximization in Massive MIMO Systems: Benefits from Deep Learning (2019)

This paper investigates the joint data and pilot<br> power optimization for maximum sum spectral efficiency (SE)<br> in multi-cell Massive MIMO systems, which is a non-convex<br> problem. We first propose a new optimization algorithm, inspired<br> by the weighted minimum mean square error (MMSE) approach,<br> to obtain a stationary point in polynomial time. We then use this<br> algorithm together with deep learning to train a convolutional<br> neural network to perform the joint data and pilot power<br> control in sub-millisecond runtime, making it suitable for online<br> optimization in real multi-cell Massive MIMO systems. The<br> numerical result demonstrates that the solution obtained by the<br> neural network is 1% less than the stationary point for four-cell<br> systems, while the sum SE loss is 2% in a nine-cell system
Ultrasound propagation measurements and applications (1977)

This paper reviews three systems designed for accurately measuring the propagation of ultrasonic pulses. The three systems are presented in order of velocity-measuring precision: + or - 100 ns, + or - 1 ns, + or - 0.2 ns. Also included is a brief discussion of phase and group velocities, with reference to dispersive, highly attenuating materials. Measurement of attenuation by pulse-echo buffer rod techniques is described briefly. These techniques and instruments have been used to measure sound velocity and attenuation in a variety of materials and shapes, over a wide temperature range.
Production and Characterization of Single-Crystal FeCo Nanowires Inside Carbon Nanotubes (2005)

We describe the synthesis of novel monocrystalline FeCo nanowires encapsulated inside multiwalled carbon nanotubes (MWNTs). These FeCo nanowires exhibit homogeneous Fe and Co concentrations and do not contain an external oxide layer due to the presence of insulating nanotube layers. The method involves the aerosol thermolysis of toluene-ferrocene-cobaltocene solutions in inert atmospheres. The materials have been carefully characterized using state-of-the-art high-resolution transmission electron microscopy (HRTEM), electron-energy-loss spectroscopy (EELS), scanning electron microscopy (SEM), energy-dispersive X-ray analysis (EDX), electron diffraction, HREELS-STM elemental mapping, X-ray powder diffraction, and SQUID magnetometry. We noted that the formation of FeCo alloys occurs at relatively low pyrolytic temperatures (e.g., 650-750 degrees C). These single-crystal nanowires, which have not been reported hitherto, always exhibit the FeCo (110) plane parallel to the carbon nanotube axis. The FeCo nanomaterials have shown large coercive fields at room temperature (e.g., 900 Oe). We envisage that these aligned ferromagnetic nanowires could be used in the fabrication of high-density magnetic storage devices and magnetic composites.
Monoclonal Gammopathy of Undetermined Significance (MGUS)—Not So Asymptomatic after All (2020)

Monoclonal Gammopathy of Undetermined Significance (MGUS) is considered to be a benign precursor condition that may progress to a lymphoproliferative disease or multiple myeloma. Most patients do not progress to an overt condition, but nevertheless, MGUS is associated with a shortened life expectancy and, in a minority of cases, a number of co-morbid conditions that include an increased fracture risk, renal impairment, peripheral neuropathy, secondary immunodeficiency, and cardiovascular disease. This review aims to consolidate current evidence for the significance of these co-morbidities before considering how best to approach these symptoms and signs, which are often encountered in primary care or within a number of specialties in secondary care.
First transcatheter implantations of aortic valve in Serbia 2014. (2014)

We present first two cases of successful transcatheter implantation of self-expandable aortic valve (Corevalve, Medtronic) performed at Cardiology clinic, Clinical center of Serbia. The procedures were performed in patients with severe aortic stenosis and high surgical risk. Both interventions were successfully performed without significant periprocedural complications. With successful implementation of those 2 aortic valves, our center continues with new enthusiasm strategic development of program of percutaneous treatment of structural heart diseases.
In Situ XPS for Evaluating Ceria Oxidation States in SOFC Anodes (2009)

Ceria is being considered as an electrocatalyst component for fuel-flexible SOFC anodes. With Ce3+ and Ce4+ oxidation states, ceria can function as a mixed ionic-electronic conductor, transporting both O2- ions and electrons. It remains unclear what role these oxidation states play during SOFC operation. This study addresses these issues using ambient-pressure XPS in a single-chamber cell to characterize thin-film CeO2-x electrodes on a YSZ electrolyte during electrochemical oxidation of H2 and reduction of H2O at 620 {degree sign}C. Voltage-current curves for the ceria film electrodes reveal sharp changes in resistance as a function of applied voltage from positive to negative bias. XPS measurements during electrochemical characterization show the extent of near-surface Ce4+ reduction to Ce3+ with increasing cell voltage. Increased oxidation to Ce4+ at large negative voltages correlates with a resistance drop due to H2 oxidation activity. These findings provide insight into how CeO2-x influences electrochemical fuel oxidation or H2O reduction.
Arthroconidia in coccidioidoma: Case report and literature review (1998)

Coccidioides immitis is a dimorphic fungus capable of causing a diverse spectrum of disease in humans. Although the diagnostic pathologic finding in tissue is a mature endosporulating spherule, hyphal structures can also be found in over 50% of pathologic specimens. This report presents a case of coccidioidomycosis in which there were no intact spherules, but characteristic barrel shaped arthrospores present in tissue and cultures positively identified the organism as C. immitis. This case was further complicated by presentation in a nonendemic area for the fungus. Coccidioides immitis is a soil fungus with two distinct phases: the saprophytic and the parasitic. This biphasic life cycle was first described by Ophöls,1 and more fully characterized by Baker and colleagues. The saprophytic stage occurs in the environment with the organism existing in a mycelial state. As the mold matures, barrel-shaped arthroconidia form and alternate with empty cells. The arthroconidia subsequently fracture from hyphae and are dispersed as an aerosol. The saprophytic cycle repeats itself upon infection of a new soil site. However, if the airborne arthroconidia are inhaled by a susceptible host, the parasitic phase is initiated. In the parasitic cycle, the arthrospore swells and becomes a rounded structure, known as a spherule. The protoplasm of the spherule divides to form large numbers of endospores. If the spherule ruptures, the endospores are released. Each endospore can develop into a new spherule, or, upon expulsion via contaminated secretions from the host, return to the environment where it transforms into its mycelial form. Although the characteristic histologic finding in coccidioidomycosis is the spherule with endospores, hyphal forms also can be found. The mycelial form of C. immitis cannot be definitively identified morphologically and requires confirmation by culture techniques or genetic probes. This report presents a pulmonary coccidioidoma in which arthroconidia were the predominant forms found in tissue.
Frictional studies of a monolayer coated micromachined actuator: Beyond Amontons laws (2018)

Abstract not provided.
Multi-grid, Multi-level Analysis of Printed Arrays and Circuits (2002)

A technique is presented for analyzing large and complex arrays with limited numerical effort, yet without accuracy reductions. The proposed approach combines two approaches introduced by the authors in previous papers. The Synthetic basis Function eXpansion approach generates few global basis functions on portions of the array, to be used as basis functions in the array analysis, with strong reduction in memory and solving time. The Dual-Isoscalar Multi-Resolution approach manages to generate "wavelet-like" vector functions for any meshed geometry, and well controls the MoM condition number. It is intrinsically multi-grid, a property exploited here to enhance the efficiency of the SFX scheme.
Comparing frameworks and layered refinement (2001)

Object-oriented frameworks are a popular mechanism for building and evolving large applications and software product lines. This paper describes an alternative approach to software construction, Java Layers (JL), and evaluates JL and frameworks in terms of flexibility, ease of use, and support for evolution. Our experiment compares Schmidt's ACE framework against a set of ACE design patterns that have been implemented in JL. We show how problems of framework evolution and overfeaturing can be avoided using JL's component model, and we demonstrate that JL scales better than frameworks as the number of possible application features increases. Finally, we describe how constrained parametric polymorphism and a small number of language features can support JL's model of loosely coupled components and stepwise program refinement.
Curvature Prior for MRF-based Segmentation and Shape Inpainting (2011)

Most image labeling problems such as segmentation and image reconstruction are fundamentally ill-posed and suffer from ambiguities and noise. Higher order image priors encode high level structural dependencies between pixels and are key to overcoming these problems. However, these priors in general lead to computationally intractable models. This paper addresses the problem of discovering compact representations of higher order priors which allow efficient inference. We propose a framework for solving this problem which uses a recently proposed representation of higher order functions where they are encoded as lower envelopes of linear functions. Maximum a Posterior inference on our learned models reduces to minimizing a pairwise function of discrete variables, which can be done approximately using standard methods. Although this is a primarily theoretical paper, we also demonstrate the practical effectiveness of our framework on the problem of learning a shape prior for image segmentation and reconstruction. We show that our framework can learn a compact representation that approximates a prior that encourages low curvature shapes. We evaluate the approximation accuracy, discuss properties of the trained model, and show various results for shape inpainting and image segmentation.
Time for reappraisal of extracranial treatment options? (2010)

Radical thoracic treatments may be justified in selected patients <65-years-old, eligible to undergo surgery/radiosurgery for synchronous BM from NSCLC, even when stage III thoracic disease is present.
Chronic anti-platelet therapy: a contraindication for platelet-rich plasma intra-articular injections? (2014)

We report the case of a 50 years-old man who complained persisting knee pain that limited almost completely his sport performance. Since he previously underwent multiple aortocoronaric by-passes, he presented a chronic anti-aggregant therapy. In spite of this clinical history, he was still sport active and able to run long-distance races, until knee symptoms limited is activity level. Conservative treatment approaches proved to be unsuccessful, thus we decided to treat him by 3 Platelet-rich Plasma (PRP) injections even if chronic anti-aggregant therapy is generally regarded as a contra-indication for PRP, since this kind of drugs impairs platelet function and granules' release. Despite these premises, the clinical outcome was very satisfactory and the patient was able to rapidly resume intensive running activity. This experience opens new questions regarding the real potential of PRP in treating degenerative musculo-skeletal disorders, and in particular on its range of biological actions and on its limitations for clinical application.
Doxorubicin Nanocarriers Based on Magnetic Colloids with a Bio‐polyelectrolyte Corona and High Non‐linear Optical Response: Synthesis, Characterization, and Properties (2011)

Abstract Magnetic drug nanocarriers are synthesized following an arrested mineralization of magnetic spinel iron oxides in the presence of the biopolymer of sodium carboxymethylcellulose. Based on the experimental results, the polyelectrolyte corona probably attains a brushlike configuration around the magnetic particles. The inner core of these colloids may be constituted of polymer‐associated nanocrystallites, forming nanogel colloids. The hybrid colloids are endowed with a high loading capacity for the anticancer agent doxorubicin and pronounced pH responsiveness. They also display a dramatic increase in non‐linear optical response as compared to previous studies of similar materials. Furthermore, as cell studies indicate, the blank nanocarriers are cytocompatible and the drug retains its activity after loading in the nanocarriers.
[PL‐05–01–01]: CELLULAR MECHANISMS OF FRONTOTEMPORAL LOBAR DEGENERATION (FTLD) (2017)

Abstract not available.
Increased expression of the interleukin 2 (IL-2) receptor beta chain (p70) on CD56+ natural killer cells after in vivo IL-2 therapy: p70 expression does not alone predict the level of intermediate affinity IL-2 binding. (1990)

The expression of the 70-kD beta subunit of the interleukin 2 receptor (IL-2R) has been examined on peripheral blood lymphocytes (PBL) obtained from patients receiving systemic infusions of IL-2. Using monoclonal antibodies directed against p70, flow cytometric analyses revealed a greater than threefold increase in expression of the IL-2R beta chain on CD56+ natural killer (NK) cells from post-IL-2 therapy PBL relative to pre-therapy cells. The level of p70 expression on the post-therapy cells was three- to fourfold greater (based on fluorescence intensity) than the level of p70 expression on YT cells, an NK-like cell line that expresses approximately 12,000 intermediate affinity IL-2 binding sites/cell. Despite the high level of p70 expression, in 125I-IL-2 binding assays only 790-1,290 intermediate affinity IL-2 binding sites/cell were detected on post-therapy cells from six patients. These data represent the first report of increased p70 expression after in vivo IL-2 administration and suggest a requirement for at least one additional subunit for the formation of functional intermediate affinity IL-2Rs. Furthermore, the presence on the surface of post-therapy NK cells of excess p70 that does not bind IL-2 with intermediate affinity implies that the formation of intermediate affinity IL-2Rs is not solely determined by the level of p70 expression, and that the response of NK cells to IL-2 might be regulated by altering the expression of p70 or some other IL-2R subunit.
Regulatory mechanisms of deoxycytidine kinase in cancer cells: Promoter hypermethylation and micro-RNAs (2008)

2459 Deoxycytidine kinase (dCK) is the most important enzyme in the deoxyribonucleoside salvage pathway and phosphorylates a variety of deoxynucleoside analogs, such as gemcitabine and ara-C, which are frequently used as anticancer compounds. This activation to nucleotides is crucial for their activity since a dCK deficiency (dCK-) leads to resistance, while we earlier observed a highly significant relation between dCK activity and in vivo sensitivity of xenografts to gemcitabine. Therefore identification of dCK regulating mechanisms is of utmost importance. We hypothesized that epigenetic regulation could affect the function of dCK by DNA methylation of SP1 binding sites in the dCK promoter region, while posttranscriptional regulation of dCK might be mediated by micro-RNAs. To study this we used cell lines from different origins: leukemia (CEM, CEM-dCK-), NSCLC (A549, H460, SW1573), colon cancer (WiDr, HT-29, Colo320), ovarian cancer (A2780, AG6000) and the noncancerous HEK 293 cell line. In vitro sensitivity to gemcitabine was determined by SRB or MTT-assay. dCK activity was measured using chlorodeoxyadenosine as a substrate, and protein expression by Western blotting. The gemcitabine-resistant cell lines AG6000 and CEM-dCK- lacked dCK protein. The highest dCK protein expression was detected in CEM, A2780 and Colo320 cells, and the lowest dCK in A549 and HEK cells. A negative correlation was observed between dCK expression and in vitro sensitivity to gemcitabine (R=-0.74, R=0.04) in the solid tumor cell lines. To study hypermethylation of the dCK promoter region several methylation specific PCRs (MSP) were setup which identified methylation of one SP1 binding site in the dCK promoter in HEK, SW1573, Colo320, H460, and CEM cells. There was no clear correlation between methylation status and dCK protein expression. TargetScan and MiRANDA prediction algorithms revealed several possible dCK targeting miRNAs and identified hsa-mir-330 as the best hit. Expression of hsa-mir-330 as measured by Taqman analysis, revealed a large variation among cell lines and correlated with in vitro gemcitabine sensitivity (IC50s) in colorectal and lung cancer cells (R = 0.79, p= 0.03). Exposure to gemcitabine also appeared to influence mir-hsa-330 levels in these cell lines. Furthermore, hsa-mir-330 expression correlated with dCK activity (R=0.74, p=0.04) in our cell line panel, but not with dCK protein expression, suggestion a role of miRNA in regulation of dCK activity. In human xenografts (A2780, Calu, WiDR and Panc-02) hsa-mir-330 expression also correlated with dCK activity (R=1, p=0.00). In conclusion, both promoter methylation and hsa-mir-330 miRNA appear to regulate dCK expression and activity in cancer cells. Both mechanisms appear to contribute to sensitivity to deoxynucleoside analogs like gemcitabine in cancer cell lines.
Automatic Design of Binary and Multiple-Valued Logic Gates on RTD Series (2005)

In this paper, we contribute to the binary and multiple-valued applications of resonant tunneling devices (RTDs). We propose a method of systematic design of physical parameters of RTD based logic. From the abstraction of their behavior, we model the design space as a handful of systems of linear inequalities generated for a given circuit topology and an arbitrary logic function. Any valid solution reflects the physical parameters assignment that implements the function given. We solve these systems using off-the-shelf optimization tool and verify the results using SystemC based RTD circuit model. Our simulations confirm that the numerical solutions are valid parameter assignments.