gebhart/patrepeval huggingface dataset:
Anti-hepatitis G E2 antibody detection and its relation to serum HGV-RNA in patients with clotting disorders: high prevalence of HGV infection and spontaneous remission. (1998)

In a previous study, we have determined the prevalence of serum HGV-RNA in patients with congenital clotting disorders. Twenty-six (15%) of 175 patients investigated were serum HGV-RNA positive. In addition, HGV-RNA was detectable in peripheral blood mononuclear cells (PBMC) in ten percent of the cases, three of these patients were serum HGV-RNA negative. In the present study, we have determined the prevalence of anti-HGV-E2 antibodies in the same patient population. Anti-HGV-E2 as determined by ELISA was detected in 45 patients (25.7%). Forty of these patients were serum HGV-RNA negative. Ninety-two percent of the 26 HGV viremic patients and all but one patient (44 patients) with detectable anti-HGV-E2 had coinfection with the hepatitis C virus (HCV). Of these coinfected patients, 62.5% of HGV viremic patients and 53% of anti-HGV-E2 positive patients showed elevated serum ALT levels. Anti-HGV-E2 seroconversion is thus not associated with HCV infection. Two patients who were solely infected with HGV had normal serum ALT levels. In a retrospective longitudinal study, we have observed in 15 patients that serum HGV-RNA persisted during one to 19 years of follow-up, while anti-HGV-E2 was repeatedly negative. Five additional patients who were anti-HGV-E2 positive with concomitant detectable HGV-RNA (4 patients in serum and 1 patient in PBMC) became HGV-RNA negative during follow-up, ranging from 1 to 8 years after the first detection of anti-HGV-E2 antibodies. Two patients had lost anti-HGV-E2 antibodies 3 to 6 years after the seroconversion without the re-appearance of serum HGV-RNA. From these findings, it is clear that the prevalence rate of HGV infection in patients with clotting disorders as determined by PCR assay for HGV-RNA and anti-HGV-E2 by ELISA is actually higher than the prevalence of HGV viremia. Although HGV viremia may persist for longer than 19 years, most of the patients infected with HGV may clear the viremia spontaneously. The clearance of viremia is usually associated with seroconversion to anti-HGV-E2. In addition, anti-HGV-E2 may be lost during years of follow-up without the reappearance of the HGV-RNA. Although HGV infection does not seem to influence the fate of HCV infection and does not induce increased levels of serum ALT, the clinical significance of long-term infection remains to be established.
Facilitating serum determination of neuron specific enolase at clinically relevant levels by coupling on-line molecularly imprinted solid-phase extraction to LC-MS/MS (2020)

The identification and quantification of biomarkers is essential for the diagnosis, treatment, and long-term monitoring of many human diseases. In the present work, macromolecular synthetic receptors with pre-determined affinity and selectivity for the signature peptide of a prognostically significant small cell lung cancer (SCLC) biomarker - neuron-specific enolase (NSE) - were prepared in a porous polymer microsphere format using a template-directed synthesis strategy performed under precipitation polymerization conditions. The polymer microspheres were packed into short trap columns and then exploited as molecularly selective sorbents in a fully automated, on-line molecularly imprinted solid-phase extraction (MISPE) protocol. The on-line MISPE protocol was optimised with respect to the composition of the loading mobile phase, the flow rate, and the extraction time. The molecularly imprinted polymers (MIPs) showed high affinity and useful selectivity for the peptide target - the hexapeptide ELPLYR - compared to non-imprinted control polymers. The MIPs were able to retain the biomarker on-column for extraction times of up to 20 min, and the on-line MISPE method enabled complete recovery of the biomarker over the linear range 10-100 ng mL<sup>-1</sup> when the biomarker was present in spiked ammonium bicarbonate solution (R<sup>2</sup> = 0.994). For extractions of ELPLYR from very complex biological matrices, the recoveries of ELPLYR from reversed-phase SPE (RP-SPE)-treated and untreated digested human serum were 100.8 ± 6.2% and 61.6 ± 1.9%, respectively. Extractions of ELPLYR from spiked untreated digested serum were linear in the range of 7.5-375 ng mL<sup>-1</sup> (R<sup>2</sup> = 0.99). The limit of detection (LOD) and limit of quantification (LOQ) for the biomarker in digested serum were estimated to be 1.8 ng mL<sup>-1</sup> and 6.0 ng mL<sup>-1</sup>, respectively, which is below the median reference level of NSE in humans (8.6 ng mL<sup>-1</sup>). This work sets in place the basis for a new diagnostic tool for SCLC that is sensitive, robust, automated, and antibody-free, and which works very well with complex human plasma samples.
On the nature of time-varying functional connectivity in resting fMRI (2018)

The brain is a complex dynamical system composed of many interacting sub-regions. Knowledge of how these interactions reconfigure over time is critical to a full understanding of the brain’s functional architecture, the neural basis of flexible cognition and behavior, and how neural systems are disrupted in psychiatric and neurological illness. The idea that we might be able to study neural and cognitive dynamics through analysis of neuroimaging data has catalyzed substantial interest in methods which seek to estimate moment-to-moment fluctuations in functional connectivity (often referred to as “dynamic” or time-varying connectivity; TVC). At the same time, debates have emerged regarding the application of TVC analyses to resting fMRI data, and about the statistical validity, physiological origins, and cognitive relevance of resting TVC. These and other unresolved issues complicate the interpretation of resting TVC findings and limit the insights which can be gained from this otherwise promising research area. This article reviews the current resting TVC literature in light of these issues. We introduce core concepts, define key terms, summarize current controversies and open questions, and present a forward-looking perspective on how resting TVC analyses can be rigorously applied to investigate a wide range of questions in cognitive and systems neuroscience.
The why and how our trauma patients die: A prospective Multicenter Western Trauma Association study (2019)

Epidemiologic, level II.
Crystal Growth and Scintillation Properties of &lt;formula formulatype="inline"&gt;&lt;tex Notation="TeX"&gt;${\rm Cs}_{2}{\rm NaGdBr}_{6}{:}{\rm Ce}^{3+}$&lt;/tex&gt;&lt;/formula&gt; (2013)

Single crystals of Cs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> NaGdBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> with different Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+3</sup> activator concentrations were grown by a two-zone Bridgman method. This new compound belongs to a large elpasolite halide (A <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> BLnX <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> ) family. Many of these elpasolite compounds have shown high luminosity, good energy resolution and excellent proportionality in comparison to traditional scintillators such as CsI and NaI; therefore, they are particularly attractive for gamma-ray spectroscopy applications. This study investigated the scintillator properties of Cs <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> NaGdBr <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">6</sub> :Ce <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">+3</sup> crystals as a new material for radiation detection. Special focus has been placed on the effects of activator concentration (0 to 50 mol.%) on the photoluminescence responses. Results of structural refinement, photoluminescence, radioluminescence, lifetime and proportionality measurements for this new compound are reported.
Torque Saturation in Bipedal Robotic Walking through Control Lyapunov Function Based Quadratic Programs (2013)

This paper presents a novel method for directly incorporating user-defined control input saturations into the calculation of a control Lyapunov function (CLF)-based walking controller for a biped robot. Previous work by the authors has demonstrated the effectiveness of CLF controllers for stabilizing periodic gaits for biped walkers, and the current work expands on those results by providing a more effective means for handling control saturations. The new approach, based on a convex optimization routine running at a 1 kHz control update rate, is useful not only for handling torque saturations but also for incorporating a whole family of user-defined constraints into the online computation of a CLF controller. The paper concludes with an experimental implementation of the main results on the bipedal robot MABEL.
Plant-Mediated Effects of Beneficial Microbes and a Plant Strengthener against Spider Mites in Tomato (2023)

The two-spotted spider mite <i>Tetranychus urticae</i> is a polyphagous herbivore with a worldwide distribution, and is a serious pest in tomato and other crops. As an alternative to chemical pesticides, biological control with the release of natural enemies such as predatory mites represent an efficient method to control <i>T. urticae</i> in many crops, but not in tomato. Other biological control agents, such as beneficial microbes, as well as chemical compounds, which can act as plant defense elicitors that confer plant resistance against pests and pathogens, may prove promising biological solutions for the suppression of spider mite populations in tomato. Here, we assessed this hypothesis by recording the effects of a series of fungal and bacterial strains and the plant strengthener acibenzolar-s-methyl for their plant-mediated effects on <i>T. urticae</i> performance in two tomato cultivars. We found significant negative effects on the survival, egg production and spider mite feeding damage on plants inoculated with microbes or treated with the plant strengthener as compared to the control plants. Our results highlight the potential of beneficial microbes and plant strengtheners in spider mite suppression in addition to plant disease control.
Supplementary Figure 2 from Evolutionary Pathways in BRCA1-Associated Breast Tumors (2023)

&lt;p&gt;PDF file - 149K, Evolutionary paths and BRCA1 expression in breast tumors.&lt;/p&gt;
Melatonin-micronutrients Osteopenia Treatment Study (MOTS): a translational study assessing melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7) on bone density, bone marker turnover and health related quality of life in postmenopausal osteopenic women following a one-year double-blind RCT and on osteoblast-osteoclast co-cultures (2017)

This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral density (BMD) and quality of life (QOL) in postmenopausal osteopenic women (ages 49-75). Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%), with an upward trend for total left hip (p=0.069). MSDK increased serum P1NP levels and reduced bone turnover (CTx:P1NP). Psychometric analyses indicated that mood and sleep quality improved for the MSDK group. MSDK-exposed human mesenchymal stem cells (hMSCs) and human peripheral blood monocytes (hPBMCs) plated in transwells or layered demonstrated increases in osteoblastogenesis, decreases in osteoclastogenesis, increases in OPG (TNFRSF11B) and decreases in RANKL (TNFSF11) levels. In transwell osteoblasts, MSDK increased pERK1/2 (MAPK1/MAPK3) and RUNX2 levels; decreased ERK5 (MAPK7); and did not affect the expression of NFκB (NFKB1) and β1integrin (ITGB1). In layered osteoblasts, MSDK also decreased expression of the metabolic proteins PPARγ (PPARG) and GLUT4 (SLC2A4). In adipose-derived human MSCs, MSDK induced osteoblastogenesis. These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis or other bone-related diseases.
Functionally Layered Dendrimers:  A New Building Block and Its Application to the Synthesis of Multichromophoric Light-Harvesting Systems (2005)

[reaction: see text] A divergent synthesis of internally functionalized dendrimers based on a modular functional monomer has been developed. This strategy was applied to the construction of a light-harvesting dendrimer containing one set of naphthopyranone dyes located at the interior and another set of coumarin chromophores located in the adjacent outer layer surrounding a porphyrin acceptor. Quantitative energy transfer from both donor pigments is observed, giving rise to exclusive emission from the porphyrin core over all excitation wavelengths.
Data shuffling with hierarchical tuple spaces (2023)

Methods and systems for shuffling data are described. A processor may generate pair data from source data. The processor may insert the pair data into local tuple spaces. In response to a request for a particular key, the processor may determine a presence of the requested key in a global tuple space. The processor may, in response to a presence of the requested key in the global tuple space, update the global tuple space. The update may be based on the pair data among the local tuple spaces including the existing key. The processor may, in response to an absence of the requested key in the global tuple space, insert pair data including the missing key from the local tuple spaces into the global tuple space. The processor may fetch the requested pair data, and may shuffle the fetched data to generate a dataset.
Session details: Session 3A: Soft, Silky, Stretchy (2019)

No abstract available.
Influence of Reducing Gas Composition on Disintegration Behavior of Iron Ore Agglomerates (2017)

H2 injection through the shaft into blast furnace (BF) is a potential option for a further reduction of CO2 emission from BF. H2 promotes reduction reaction of burden materials, but its influence on their reduction disintegration behavior remains unknown in detail. This study has investigated the influence on the iron ore sinter, self-fluxed and acid pellets and specified essential factors governing the reduction disintegration behavior.
Total Synthesis of Brevisamide (2009)

A convergent synthesis of brevisamide (1) is described based on the application of the crotyl silane-based [4 + 2]-annulation used for the preparation of the advanced oxygenated tetrahydropyran intermediate 2. The side chain bearing a conjugated (E,E)-diene was efficiently constructed under modified Negishi cross-coupling conditions.
Local and distributed fMRI changes induced by 40Hz gamma tACS of the bilateral dorsolateral prefrontal cortex (2021)

Abstract Over the past few years, the possibility of modulating fast brain oscillatory activity in the gamma (γ) band through transcranial alternating current stimulation (tACS) has been discussed in the context of both cognitive enhancement and therapeutic scenarios. Several neuropsychiatric and neurodegenerative disorders are characterized by abnormal fast brain oscillatory activity in the γ band (35 to 100 Hz), and the potential of restoring γ oscillations through tACS or sensory stimulation in humans has been proposed. However, the effects of tACS outside the motor cortex, as well as its spatial specificity, are still unclear. We present a tACS study with stimulation administered inside the scanner during functional magnetic resonance imaging (fMRI) to characterize the impact of 40Hz-tACS applied over the left and right dorsolateral prefrontal cortex (DLPFC) using a block design in healthy subjects. Results suggest an increase in Blood Oxygenation Level Dependent (BOLD) activity in the bilateral DLPFC as the primary stimulation target, as well as in surrounding brain areas affected by stimulation according to biophysical modeling, i.e., the premotor cortex and anterior cingulate cortex (ACC). However, off-target effects were also observed, primarily involving the visual cortices, arguably as a result of phosphene perception, with further effects on the supplementary motor areas (SMA), left subgenual cingulated, and right superior temporal gyrus. The online effects of 40Hz-tACS applied during resting-state provides relevant details on modeling-based target engagement and network-level effects. The specificity of 40Hz-tACS over bilateral DLPFC should be considered especially in the context of recently promoted gamma-induction therapeutic protocols in neurodegenerative disorders where dysregulation of this activity has been seen. Keywords: Gamma-tACS, Dorsolateral Prefrontal Cortex, tACS-fMRI, Modeling
Compact Low-Loss Integration of High-$Q$ 3-D Filters With Highly Efficient Antennas (2011)

A novel synthesis technique to integrate high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> 3-D filters with highly efficient slot antennas is presented in this paper. This technique allows for compact integration of 3-D filters and antennas with very high antenna efficiency and significantly reduced form factor of integrated RF front ends. Prototype four-pole Chebyshev cavity filters integrated with slot antennas are demonstrated at <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">X</i> -band using both coaxial and coplanar waveguide feeding. The center frequency and fractional bandwidth of the filter/antenna system with coaxial feeding are 9.96 GHz and 6.0%, respectively. Due to the high- <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Q</i> factor (~850) of the cavity resonator, the efficiency of this filter/antenna system is measured to be 89%, compared with the measured <i xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">S</i> <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">21</sub> of -0.5 dB (89%) for an identical filter. This means a near 100% efficient slot antenna is achieved within this integrated filter/antenna system. The measured impedance matching, efficiency, gain, and radiation pattern closely agree with simulation results. Equivalent-circuit models of the integrated filter/antenna system are developed and verified with full-wave simulations. This technique can be applied for filter/antenna integration in all microwave, millimeter-wave, and submillimeter-wave frequency regions.
640 Gb/s RZ eye-diagram evaluation by optical sampling oscilloscope w/o post-processing and ms refresh time (2008)

A polarization insensitive quasi-asynchronous optical sampling oscilloscope with sub-ps-resolution is presented. The scheme is able to resolve tens of ns and provides eye-diagram functionality. Experimental results for a 640 Gb/s data frame are reported.
Antibacterial Activity and Various Antibiotics against Oral Streptocci Isolated in the Oral Cavity (2012)

A total of 550 oral streptococci: 270 Streptococcus mitis, 110 Streptococcus sanguis, 90 Streptococcus anginosus, 50 Streptococcus mutans, 30 Streptococcus salivarius, were isolated from dental plaque and gengival crevices of patients and tested for their susceptibility to 12 β-lactam antibiotics and to 5 non-β-lactam antibiotics, using the microdiluition method. Overall, a reduced susceptibility to penicillin was recorded in 13.4% of cases. The percentage of strains resistant to penicillin appeared significantly higher in S. mitis (24%) than in S. sanguis (19%), in S. mutans (14%) and in S. salivarius (10%). No levels of penicillin resistance were shown by 90 strains of S. anginosus. In susceptibility test to antibiotics, imipenem was the most active molecule tested, confirming its general good activity against oral streptococci. Also third generation cephalosporins such as ceftriaxone and fourth generation cephalosporins such as cefepime, showed good activity. Chinolones, glycopeptides and rifampicin confirmed a good activity against oral streptococci.
Crystallization and preliminary X-ray diffraction analysis of mouse prostaglandin F<sub>2α</sub>synthase, AKR1B3 (2011)

Aldo-keto reductase 1B3 (AKR1B3) catalyzes the NADPH-dependent reduction of prostaglandin H(2) (PGH(2)), which is a common intermediate of various prostanoids, to form PGF(2α). AKR1B3 also reduces PGH(2) to PGD(2) in the absence of NADPH. AKR1B3 produced in Escherichia coli was crystallized in complex with NADPH by the sitting-drop vapour-diffusion method. The crystal was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 Å. X-ray diffraction data were collected to 2.4 Å resolution at 100 K using a synchrotron-radiation source.
A Dielectric Heating Analysis Method With Accurate Rotational Motion of Stirrer Fan Using Nonconforming Mesh Connection (2008)

In order to evaluate the heating process of the target and the optimal structure of cavity in a furnace for dielectric heating, such as a microwave oven, the coupled analysis method composed of electromagnetic wave and heat conduction is a powerful tool for practical design. In this paper, we proposed the electromagnetic wave analysis method with a nonconforming mesh connection to take account of the rotational motion of the specific objects in a cavity resonator. The features such as a numerical error and convergence characteristics of the ICCOCG method were investigated, and the proposed method was applied to the dielectric heating analysis of the cavity resonator with rotation of stirrer fans.
Bounded-hops power assignment in ad-hoc wireless networks (2004)

Motivated by topology control in ad-hoc wireless networks, power assignment is a family of problems, each defined by a certain connectivity constraint (such as strong connectivity). These problems have been studied in the past. In this paper we consider delay bounds as an additional constraint to provide quality of service. Delay is measured by the number of hops on a path between two nodes. We present an algorithm for minimum power bounded hops broadcast with guaranteed bicriteria ratio of (O(log n), O(log n)) for general graphs. That is, in the solution produced by our algorithm, the number of hops between the root and any other node is at most O(log n) times the given bound and the power is at most O(log n) times the power of optimal solution. Our bicriteria results extend to min-power bounded-hops strong connectivity (the solution must have a path of at most d edges in between any two nodes) and min-power bounded-hops symmetric connectivity (the undirected graph having an edge uv iff the solution has both uv and vu is required to have diameter at most d). Previous work for min-power bounded-hops strong connectivity consists only of constant or better approximation for special cases of the Euclidean case. We also provide better guarantees for the Euclidean cases by post processing solutions of the main algorithm.