gebhart/patrepeval huggingface dataset:
Studies on the chemical reactivity of bicyclomycin: acid hydrolysis (1988)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the chemical reactivity of bicyclomycin: acid hydrolysisHarold Kohn and Syed AbuzarCite this: J. Org. Chem. 1988, 53, 12, 2769–2773Publication Date (Print):June 1, 1988Publication History Published online1 May 2002Published inissue 1 June 1988https://pubs.acs.org/doi/10.1021/jo00247a020https://doi.org/10.1021/jo00247a020research-articleACS PublicationsRequest reuse permissionsArticle Views89Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Challenges in coronagraph optical design (2017)

The point spread function (PSF) for astronomical telescopes and instruments depends not only on geometric aberrations and scalar wave diffraction, but also on the apodization and wavefront errors introduced by coatings on reflecting and transmitting surfaces within the optical system. Geometrical ray tracing provides incomplete image simulations for exoplanet coronagraphs with the goal of resolving planets with a brightness less than 10^-9 of their star located within 3 Airy disk radii. The Polaris-M polarization analysis program calculates uncorrected coating polarization aberrations couple around 10^-5 light into crossed polarized diffraction patterns about twice Airy disk size. These wavefronts not corrected by the deformable optics systems. Polarization aberrations expansions have shown how image defects scale with mirror coatings, fold mirror angles, and numerical aperture.
A novel CD45RA<sup>+</sup>CD4<sup>+</sup> transient thymic subpopulation in MRL-<i>lpr/lpr</i> mice: its relation to non-proliferating CD4<sup>−</sup>CD8<sup>−</sup>CD45RA<sup>+</sup> tumor cells (1993)

MRL-lpr/lpr mice have hypertrophied lymph nodes comprising CD4-CD8- T cells. In addition, they contain CD4+CD8- T cells co-expressing the CD45RA marker. The correlation between these two subpopulations has been difficult to assess. We analyzed the expression of CD45RA (with the RA3-2C2 antibody) in various thymic and peripheral T cell subsets, using three-color immunofluorescence. We showed that in lpr mice (i) a transient CD4+CD8- thymic subset co-expresses CD45RA during the course of the disease, and (ii) thymic as well as peripheral CD4-CD8- and CD4+CD8- T cells brightly express CD45RA; furthermore (iii) in the lymph nodes, during lymphadenopathy, CD4+CD8-CD45RA+ T cells show a broad range of the CD4 fluorescence intensity, and (iv) the increase in MHC class II expression is restricted to CD45RA-T cells of the thymus and lymph nodes of lpr mice. Taken together, these data suggest that the CD4+CD8-CD45RA+ population might generate the CD4-CD8- tumor cells. In addition, using the bromodeoxyuridine labeling technique, we demonstrate that these cells are not the result of increased proliferation.
Adaptive Optical Network Unit for Point-to-Point and PON Systems Based on Gigabit Ethernet (2009)

This paper proposes an optical network unit (ONU) that works in point-to-point (P2P) optical access systems as well as passive optical network (PON) systems and so reduces the operational expenditure of optical access networks in the full FTTH era. First, we discuss its design and implementation; after clarifying the requirements for the adaptive ONU, we describe how it should work while focusing on Gigabit-Ethernet-based P2P and PON systems. Next, we study its feasibility through experiments on a prototype. Also, we provide some additional considerations regarding the implementation and future application of the adaptive ONU.
The Molecular Basis for Recognition of CD1d/α-Galactosylceramide by a Human Non-Vα24 T Cell Receptor (2012)

CD1d-mediated presentation of glycolipid antigens to T cells is capable of initiating powerful immune responses that can have a beneficial impact on many diseases. Molecular analyses have recently detailed the lipid antigen recognition strategies utilized by the invariant Vα24-Jα18 TCR rearrangements of iNKT cells, which comprise a subset of the human CD1d-restricted T cell population. In contrast, little is known about how lipid antigens are recognized by functionally distinct CD1d-restricted T cells bearing different TCRα chain rearrangements. Here we present crystallographic and biophysical analyses of α-galactosylceramide (α-GalCer) recognition by a human CD1d-restricted TCR that utilizes a Vα3.1-Jα18 rearrangement and displays a more restricted specificity for α-linked glycolipids than that of iNKT TCRs. Despite having sequence divergence in the CDR1α and CDR2α loops, this TCR employs a convergent recognition strategy to engage CD1d/αGalCer, with a binding affinity (∼2 µM) almost identical to that of an iNKT TCR used in this study. The CDR3α loop, similar in sequence to iNKT-TCRs, engages CD1d/αGalCer in a similar position as that seen with iNKT-TCRs, however fewer actual contacts are made. Instead, the CDR1α loop contributes important contacts to CD1d/αGalCer, with an emphasis on the 4'OH of the galactose headgroup. This is consistent with the inability of Vα24- T cells to respond to α-glucosylceramide, which differs from αGalCer in the position of the 4'OH. These data illustrate how fine specificity for a lipid containing α-linked galactose is achieved by a TCR structurally distinct from that of iNKT cells.
&lt;title&gt;Design in 3D geometry with the simultaneous multiple surface design method of nonimaging optics&lt;/title&gt; (1999)

The Simultaneous Multiple Surfaces of Nonimaging Optics has been used successfully in the past for the synthesis of concentrators in two dimensions. In this paper we present a first approach to extend this design method to 3D geometry. As a first result, an aspheric lens without rotational symmetry that focus sharply two plane wavefronts at two points in 3D geometry is found, feature which cannot be obtained with an axisymmetric optical system with a finite number of optical surfaces.
Schaechter's Mechanisms of Microbial Disease (2021)

Now in full color, the Fourth Edition of this text gives students a thorough understanding of microbial agents and the pathophysiology of microbial diseases. The text facilitates learning and recall by emphasizing unifying principles and paradigms, rather than forcing students to memorize isolated facts by rote. Case studies with problem-solving questions give students insight into clinical applications of microbiology. Each chapter ends with review and USMLE-style questions. For this edition, all schematic illustrations have been re-rendered in full color and new illustrations have been added. A new online site for students includes animations, USMLE-style questions, and all schematic illustrations and photographs from the text.
Downlink Performance Improvements in (A)synchronous GPRS Networks using Single/Multiple Antenna Interference Cancellation Techniques (2006)

Abstract: The aim of this paper is to assess GPRS data throughput of GSM networks for single and multiple antenna interference cancellation (SAIC/MAIC) receivers in the terminals. This is done by using a two-step top-down simulation methodology. Both synchronous and asynchronous networks with traditional European reuses of 1/3 and 3/9 are considered. It turns out that SAIC/MAIC receivers are very beneficial also for European network planning. The results indicate a substantial gain in data throughput in the order of 20-35% for SAIC compared to terminals with a conventional receiver. A further dramatic increase in throughput up to 120 % can be achieved by terminals using an MAIC receiver. In spite of the widespread view that a maximum gain will be achieved for a synchronized network, where the amount of overlap between desired signal and interference can be controlled, our results show that the performance of both network types is very similar. 1.
MicroRNA-200c Modulates the Expression of MUC4 and MUC16 by Directly Targeting Their Coding Sequences in Human Pancreatic Cancer (2013)

Transmembrane mucins, MUC4 and MUC16 are associated with tumor progression and metastatic potential in human pancreatic adenocarcinoma. We discovered that miR-200c interacts with specific sequences within the coding sequence of MUC4 and MUC16 mRNAs, and evaluated the regulatory nature of this association. Pancreatic cancer cell lines S2.028 and T3M-4 transfected with miR-200c showed a 4.18 and 8.50 fold down regulation of MUC4 mRNA, and 4.68 and 4.82 fold down regulation of MUC16 mRNA compared to mock-transfected cells, respectively. A significant reduction of glycoprotein expression was also observed. These results indicate that miR-200c overexpression regulates MUC4 and MUC16 mucins in pancreatic cancer cells by directly targeting the mRNA coding sequence of each, resulting in reduced levels of MUC4 and MUC16 mRNA and protein. These data suggest that, in addition to regulating proteins that modulate EMT, miR-200c influences expression of cell surface mucins in pancreatic cancer.
1-Phenyl-2-pyrrolidinyl-cyclopentylamine via Thermal Rearrangement (2011)

Abstract Thermal rearrangement of aminoimine, 1, followed by hydrogenation produced 1-phenyl-2-pyrrolidinyl cyclopentylamine 3. The structure and stereochemistry of this novel amine 4 was identified by x-ray crystallography of the 2-chloro-6-iodo-nicotinamide derivative as a hydrogen maleate salt.
ChemInform Abstract: Zeolites and Related Materials in Organic Syntheses. Bronsted and Lewis Catalysis (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Enhancement of Diamond Nucleation by Atomic Silicon Microaddition (2012)

The enhancement of diamond nucleation by atomic silicon microaddition is demonstrated. From the observation by surface-enhanced Raman scattering (SERS), the mechanism of bias-enhanced nucleation (BEN) with atomic silicon microaddition is discussed. We propose two nucleation processes, namely, i) generation in condensed amorphous carbon (a-C) and ii) carbon cohesion with the adsorbed silicon atom as the core. It is shown that the nucleation process ii) induces highly oriented diamond growth on Si substrates.
Cellular Activity on Siloxane-Doped Poly(Lactic Acid)/Vaterite Composite Scaffolds (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Improving fatigue performance of rail thermite welds (2010)

Rail transport development offers economic and ecological interests. Nevertheless, it requires heavy investments in rolling material and infrastructure. To be competitive, this transportation means must rely on safe and reliable infrastructure, which requires optimization of all implemented techniques and structure. Rail thermite (or aluminothermic) welding is widely used within the railway industry for in-track welding during re-rail and defect replacement. The process provides numerous advantages against other welding technology commonly used. Obviously, future demands on train traffic are heavier axle loads, higher train speeds and increased traffic density. Thus, a new enhanced weld should be developed to prevent accidents due to fracture of welds and to lower maintenance costs.
Selective catalytic hydrogenation of polycyclic aromatic hydrocarbons promoted by ruthenium nanoparticles (2015)

Naphthalene, anthracene, triphenylene and pyrene were partially hydrogenated with selectivities between 80% and 100% under mild conditions using ruthenium NPs.
The Adequacy of Phase-Averaged Models for Modelling Wave Farms (2011)

As the wave energy industry develops there is a need to develop tools for the estimation of the energy yield from wave farms, as well as determination of the environmental impact of wave farms and optimisation of wave farm layout. Tools based on spectral wave models are potentially suitable for these tasks and are already used extensively in coastal engineering to estimate wave climate and how waves affect the coastal environment. Examples of these tools include software packages such as SWAN, TOMAWAC and Mike21SW. However, a fundamental characteristic of spectral wave models is that they are phase-averaged models, which implies that the phase of individual wave components is unknown. Interactions between wave energy converters (WECs) in an array have been previously modelled using linear wave theory. These models have shown that phase can be important in determining the interaction between WECs in an array due to the effects of radiated waves. However, these models have typically assumed that the WECs have ideal control. The array interactions for more realistic control strategies are much weaker. In this paper arrays of realistically controlled WECs are modelled using hydrodynamic coefficients obtained from WAMIT, a linear hydrodynamic panel code, to determine the effects that radiated wave amplitude and WEC separation distance have on array interactions. It is shown that array interactions decrease with decreasing radiated wave amplitude and increasing separation distance. Array interactions are shown to change the power capture by less than 10% for typical WECs with realistic control. Moreover, it is shown that the change in power capture becomes highly sensitive to wave frequency and direction as the separation distance increases, although the magnitude of the interaction factor reduces. Finally, realistic wave spectra are applied to the array interactions of WECs. The average array interaction factor is found to be relatively insensitive to the mean wave period and direction. It is argued that this implies that phase-averaged models are adequate for modelling realistically controlled wave farms operating in realistic wave spectra. Consequently, provided a suitable phase-averaged model of a WEC can be developed, then it can be modelled with reasonable accuracy in spectral wave models.
Recovery Focused Nutritional Therapy across the Continuum of Care: Learning from COVID-19 (2021)

Targeted nutritional therapy should be started early in severe illness and sustained through to recovery if clinical and patient-centred outcomes are to be optimised. The coronavirus disease 2019 (COVID-19) pandemic has shone a light on this need. The literature on nutrition and COVID-19 mainly focuses on the importance of nutrition to preserve life and prevent clinical deterioration during the acute phase of illness. However, there is a lack of information guiding practice across the whole patient journey (e.g., hospital to home) with a focus on targeting recovery (e.g., long COVID). This review paper is of relevance to doctors and other healthcare professionals in acute care and primary care worldwide, since it addresses early, multi-modal individualised nutrition interventions across the continuum of care to improve COVID-19 patient outcomes. It is of relevance to nutrition experts and non-nutrition experts and can be used to promote inter-professional and inter-organisational knowledge transfer on the topic. The primary goal is to prevent complications and support recovery to enable COVID-19 patients to achieve the best possible nutritional, physical, functional and mental health status and to apply the learning to date from the COVID-19 pandemic to other patient groups experiencing acute severe illness.
Development and Optimization of Organic Based Monoliths for Use in Affinity Chromatography (2011)

Affinity chromatography is an important and useful tool for studying biological interactions, such as the binding of an antibody with an antigen. Monolithic supports offer many advantages over traditional packed bed supports in affinity chromatography, including their ease of preparation, low back pressures and good mass transfer properties. Monoliths can be broken down into two basic categories: organic (polymer) and inorganic (silica) monoliths. There are many varieties of polymer based monoliths; however, a large focus has been on co-polymers of glycidyl methacrylate (a functional monomer) and ethylene dimethacrylate (a cross-linking agent). The solvents of choice for making this type of monolith are typically 1-dodecanol and cyclohexanol. The combination of monolith supports with biological ligands of interest in affinity chromatography has given rise to a technique known as affinity monolith chromatography (AMC). In order to study the conditions needed for preparing affinity monolithic supports, a combinatorial library was prepared in which the polymerization temperature and relative ratio of cyclohexanol to1-dodecanol was varied to determine the effects on the total protein content that could be achieved with such materials. In the first of this work, glycidyl methacrylate was used along with a cross linking agent that was either ethylene dimethacrylate or trimethylolpropane trimethacrylate. It was found that changing the ratio of these agents could be used to obtain a high protein content for monoliths containing immobilized human serum albumin (HSA). It was also found that these materials could be used for the separation of chiral substances such as (R/S)-warfarin and (D/L)-tryptophan. The second study utilized a monolith comprised of a co-polymer of glycidyl methacrylate and ethylene dimethacrylate to examine the effectiveness of this material to entrap carbon-based nanomaterials for eventual use in characterizing such materials or using them in separations based on biologically-relevant proteins or ligands. Adviser: David S. Hage
Proline reduction by<i>Clostridium sporogenes</i>is coupled to vectorial proton ejection (1986)

The reduction of proline by Clostridium sporogenes NCIB8053 is coupled to transmembrane proton translocation in an uncoupler-sensitive fashion (and might therefore conserve free energy). This finding serves to explain the increase in the growth yield of this organism when proline is added to a defined growth medium containing glucose as the catabolic substrate.
Platinum Complexes Can Inhibit Matrix Metalloproteinase Activity:  Platinum−Diethyl[(methylsulfinyl)methyl]phosphonate Complexes as Inhibitors of Matrix Metalloproteinases 2, 3, 9, and 12 (2007)

Platinum complexes able to inhibit matrix metalloproteinases (MMPs) through a noncompetitive mechanism are reported for the first time in this study. [PtCl2(SMP)] and [Pt(dimethylmalonato)(SMP)], characterized by the bisphosphonate-analogue ligand diethyl[(methylsulfinyl)methyl]phosphonate (SMP), are slight inhibitors of MMP-2 (IC50 = 258 +/- 38 and 123 +/- 14 microM, respectively) but markedly inhibit MMP-9 (IC50 = 35.5 +/- 6 and 17 +/- 4 microM), MMP-3 (IC50 = 5.3 +/- 2.9 and 4.4 +/- 2.2 microM), and MMP-12 (IC50 = 10.8 +/- 3 and 6.2 +/- 1.8 microM). In contrast, cisplatin, carboplatin, and the SMP ligand are inactive, and the bisphosphonate clodronate shows a broad-spectrum inhibitory activity in the high micromolar range (mean IC50 > 200 microM). These results, along with mechanistic investigations (DNA interaction and tumor cell growth inhibition), demonstrate that ligand modifications of platinum compounds can be exploited to target also biological substrates distinct from DNA.
ChemInform Abstract: Multifunctional Peptide Synthetases (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Study on the Mechanism of Improvement of Realistic Sensation on Driving Simulator Based on Measurement of Cortical Brain Activity for Sign and Information Boards (2016)

Recently, driving simulator(DS) has been widely used in various research fields such as assessment of traffic safety countermeasure. To be used at more diverse research areas, it is important to improve realistic sensation of DS. In this paper, we have focused on driver’s cognition status for sign and information boards in highway. By using measurement of cortical brain activity, we will analyze data. With data from analyzing, we will compare real car experiment environment and DS experiment environment and find mechanism to improve the realistic sensation of DS.
Multifunctional semiconductor laser amplifiers: optical amplifier, detector, gate switch, and transmitter (1990)

Semiconductor laser amplifiers (SCLAs) are expected to play an important role in future transmission and switching systems for various applications, such as optical preamplifiers and repeaters and in local area network applications as loss compensators and as gate switches for modulation and (using the feature of simultaneous amplification and detection) for intelligent switching and routing functions. 1-5 However, it would be of great interest if also a laser type transmitter could be based on the optical amplifier. Such a possibility would substantially increase the utility of near-traveling-wave (NTW) SCLAs in optical communications systems. The number of different structures for implementing amplifiers, detectors, gate switches, and transmitters would be reduced, thus simplifying the fabrication of various complex integrated photonics components.
Steroid receptor folding and signaling is regulated by the Hsp70 cochaperones BAG-1M and HspBP1 (2009)

A correct conformation is essential for all proteins to exert their cellular functions. Approximately 15% of all proteins depend on folding assistance by chaperones, including steroid receptors such as the glucocorticoid receptor (GR). Mis-folding of GR leads to severe malfunctioning and represents a potential cause for the glucocrticoid resistance observed in many depressed patients. One of the essential players in protein folding is heat shock protein 70 (hsc/hsp70). Assisted protein folding is an energy-dependent process and requires ATPase activity of hsc70, which additionally involves nuclear exchange factors (NEFs). Two structurally distinct proteins acting as NEF for hsc70 are known: bcl-2 associated athanogene 1 (BAG-1) and hsp70 binding protein 1 (HspBP1). BAG-1M was shown to bind to GR and to inhibit its action as transcription factor. The effect of HspBP1 on GR or related steroid receptors is not known. In this study, we demonstrate that over expression of HspBP1 inhibits GR similarly to BAG-1M but exhibits a different effect on androgen receptor (AR) function. We show minor differences in the binding profile of receptors and cofactors to the two NEFs. Furthermore, both proteins inhibit MR function in an hsp70- and hormone-dependent manner. Taken together, our results suggest, that HspBP1, and BAG-1M possess characteristics to be a candidate causing glucocorticoid resistance.