gebhart/patrepeval huggingface dataset:
Amino Acid Conjugation Responses to 2-Naphthylacetic Acid in Rodents (1979)

Conference Article| June 01 1979 Amino Acid Conjugation Responses to 2-Naphthylacetic Acid in Rodents TOWUANSE S. EMUDIANUGHE; TOWUANSE S. EMUDIANUGHE 1Department of Biochemical and Experimental Pharmacology, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar JOHN CALDWELL; JOHN CALDWELL 1Department of Biochemical and Experimental Pharmacology, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar ROBERT L. SMITH ROBERT L. SMITH 1Department of Biochemical and Experimental Pharmacology, St. Mary's Hospital Medical School, London W2 1PG, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1979) 7 (3): 522–523. https://doi.org/10.1042/bst0070522 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation TOWUANSE S. EMUDIANUGHE, JOHN CALDWELL, ROBERT L. SMITH; Amino Acid Conjugation Responses to 2-Naphthylacetic Acid in Rodents. Biochem Soc Trans 1 June 1979; 7 (3): 522–523. doi: https://doi.org/10.1042/bst0070522 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1979 Biochemical Society1979 Article PDF first page preview Close Modal You do not currently have access to this content.
Performance of an endcap prototype of the ATLAS accordion electromagnetic calorimeter (1997)

The design and construction of a lead-liquid-argon endcap calorimeter prototype using an accordion geometry and conceived as a sector of the inner wheel of the endcap calorimeter of the future ATLAS experiment at the LHC is described. The performance obtained using electron beam data is presented. The main results are energy resolution with a sampling term below 11%EGeV and a small local constant term, good linearity of the response with the incident energy and a global constant term of 0.8% over an extended area in the rapidity range 2.2 < η < 2.9. These properties make the design suitable for the ATLAS electromagnetic endcap calorimeter.
Spray-On Polyaniline/Poly(acrylic acid) Electrodes with Enhanced Electrochemical Stability (2015)

Polyaniline (PANI)-based electrodes are promising candidates for energy storage, but their cycle life remains poor. Recent work suggests that secondary interactions may enhance polyaniline's electrochemical stability and cycle life, but evidence to date is not conclusive. Here, we investigate spray-assisted layer-by-layer assemblies containing polyaniline nanofibers (PANI NFs) or conventional PANI and poly(acrylic acid) (PAA), which provides hydrogen bonding and electrostatic interactions. This spray-on approach may be suitable for the deposition of PANI onto a variety of surfaces. The effects of PANI type, PAA pH, and PAA molecular weight on the growth behavior, conductivity, and electrochemical performance are examined. It is shown that LbL films with PANI NFs, higher molecular weight PAA, and lower PAA pH yield the thickest films, whereas the thinnest films come from conventional PANI assembled under similar conditions. Electron microscopy imaging and density measurements show that LbL films containing PANI NFs are very porous, whereas those containing conventional PANI are very dense (0.28 vs 1.33 g/cm(3), respectively). The difference in density dramatically affects the electrochemical properties in terms of capacity and long-term cycling behavior. Upon extended cycling, PANI NFs alone rapidly lose their electrochemical activity. On the other hand, PANI NF-based LbL films exhibited somewhat enhanced stability, and PANI-based LbL films were exceptionally stable, maintaining 94.7% of their capacity after 1000 cycles when cycled up to 4.2 V vs Li/Li(+). These results show that secondary interactions from PAA enhance stability, as does the selection of PANI type and the electrode's density.
Autocorrelation Constraints in Radar Waveform Optimization for Detection (2012)

We consider the design of radar transmit waveforms that are optimal for the purposes of detecting multiple unknown targets in a known interference environment. Specifically, we introduce constraints on the waveform's autocorrelation function, which is of fundamental importance in practice. The incorporation of autocorrelation constraints leaves the problem analytically intractable, and numeric techniques must be employed. We introduce the concept of "waveform optimized performance" in order to provide a framework for suggesting and analyzing various approaches. We show that unlike the solutions to the more relaxed formulations found in the literature, eigenfunction solutions are no longer optimal, and the Neyman-Pearson receiver is no longer the most appropriate choice for many scenarios. Furthermore, for some scenarios, numeric solutions to the autocorrelation-constrained problems can provide signal-to-interference-plus-noise ratio improvements comparable to the solutions of the more relaxed formulations found in the literature. \RDManuscript received March 7, 2009; revised September 7, 2010; released for publication February 21, 2011.
Free Cholesterol-Induced Cytotoxicity (1997)

A major characteristic of advanced atherosclerotic lesions is the necrotic, or lipid, core, which likely plays an important role in the clinical progression of these lesions. Recent data suggest that the necrotic core forms primarily as a consequence of macrophage foam cell necrosis. Lesional macrophages initially accumulate mostly cholesteryl esters, but macrophages in advanced lesions contain large amounts of unesterified, or free, cholesterol (FC). Although there are many theories as to why macrophage foam cells die in advanced lesions, the fact that a high FC:phospholipid (PL) ratio in cellular membranes can be toxic to cells suggests that FC-induced cytotoxicity may contribute to foam cell necrosis. The mechanism of FC cytotoxicity can be explained by disturbances in membrane protein function as a result of "stiffening" of the bilayer and by formation of intracellular FC crystals that can cause physical damage to cellular organelles. Macrophages appear to respond to FC loading by a fascinating adaptive response, namely the induction of PL biosynthesis, which initially keeps the cellular FC:PL ratio below toxic levels. Studies with cultured macrophages have demonstrated that a failure of this adaptive response leads to FC-induced foam cell cytotoxicity and necrosis, and thus a similar series of events in advanced atherosclerotic lesions could provide an explanation for the development of the necrotic core. (Trends Cardiovasc Med 1997;7: 256-263). © 1997, Elsevier Science Inc.
Laser Measurement of SAM Bulk and Surface Wave Amplitudes for Material Microstructure Analysis (2005)

Scanning Acoustic Microscopy (SAM) at ultra high frequencies has proven to be a useful tool for investigating materials on the scale of individual grains. This technique is normally performed in a reflection mode from one side of a sample surface. Information about the generation and transmission of bulk acoustic waves into the material is inferred from the reflection signal amplitude. We present an adaptation to the SAM method whereby the acoustic bulk waves are directly visualized through laser acoustic detection. Ultrasonic waves were emitted from a nominal 200 MHz point focus acoustic lens into a thin silicon plate (thickness 75ìm) coupled with distilled water. A scanned laser beam detected the bulk and surface acoustic waves at the opposite surface of the thin silicon plate. Distinct amplitude patterns exhibiting the expected symmetry for Silicon were observed that alter in predictable ways as the acoustic focal point was moved throughout the plate. Predictions of the acoustic wave fields generated by the acoustic lens within and at the surface of the Silicon are being investigated through the angular spectrum of plane waves approach. Results shall be presented for plates with (100) and (111) orientations followed by discussion of applications of the technique for material microstructure analysis.
Analysis of viscous transonic flow over airfoil sections (1987)

A full Navier-Stokes solver has been used to model transonic flow over three airfoil sections. The method uses a two-dimensional, implicit, conservative finite difference scheme for solving the compressible Navier-Stokes equations. Results are presented as prescribed for the Viscous Transonic Airfoil Workshop to be held at the AIAA 25th Aerospace Sciences Meeting. The NACA 0012, RAE 2822 and Jones airfoils have been investigated for both attached and separated transonic flows. Predictions for pressure distributions, loads, skin friction coefficients, boundary layer displacement thickness and velocity profiles are included and compared with experimental data when possible. Overall, the results are in good agreement with experimental data.
Multi-Parametric MRI-Directed Focal Salvage Permanent Interstitial Brachytherapy for Locally Recurrent Adenocarcinoma of the Prostate: A Novel Approach (2013)

Even with the technological advances of dose-escalated IMRT with the addition of the latest image guidance technologies, local failures still occur. The combination of MRI-based imaging techniques can yield quantitative information that reflects on the biological properties of prostatic tissues. These techniques provide unique information that can be used for tumor detection in the treated gland. With the advent of these improved imaging modalities, it has become possible to more effectively image local recurrences within the prostate gland. With better imaging, these focal recurrences can be differentially targeted with salvage brachytherapy minimizing rectal and bladder toxicity. Here we report a novel use of MRI-directed focal brachytherapy after local recurrence. This technique offers a unique opportunity to safely and successfully treat recurrent prostate cancer, previously treated with definitive radiation therapy. The use of multi-parametric MRI-directed focal salvage permanent interstitial brachytherapy for locally recurrent adenocarcinoma of the prostate is a promising strategy to avoid more aggressive and expensive treatments that are associated with increased morbidity, potentially improving survival at potentially lower costs.
IS-Match: Partial Shape Matching by Efficiently Solving an Order Preserving Assignment Problem (2010)

This paper introduces a novel efficient partial shape matching method named IS-Match. We use sampled points from the silhouette as a shape representation. The sampled points can be ordered which in turn allows to formulate the matching step as an order-preserving assignment problem. We propose an angle descriptor between shape chords combining the advantages of global and local shape description. An efficient integral image based implementation of the matching step is introduced which allows detecting partial matches an order of magnitude faster than comparable methods. We further show how the proposed algorithm is used to calculate a global optimal Pareto frontier to define a partial similarity measure between shapes. Shape retrieval experiments on standard shape datasets like MPEG-7 prove that state-of-the-art results are achieved at reduced computational costs.
Symmetric Dimethylarginine as Predictor of Graft Loss and All-Cause Mortality in Renal Transplant Recipients. (2014)

Elevated symmetric dimethylarginine (SDMA) has been shown to predict cardiovascular events and all cause mortality in diverse populations. The potential role of SDMA as a risk marker in renal transplant recipients (RTR) has not been investigated. We analysed SDMA in the placebo arm of the ALERT study, a randomized controlled trial of fluvastatin in RTR. Mean follow up of was 5.1 years. Patients were grouped into quartiles based on SDMA-levels at study inclusion. Relationships between SDMA and traditional risk factors for graft function and all-cause mortality were analysed in 925 RTR using uni- and multivariable survival analysis. In univariate analysis SDMA was significantly associated with renal graft loss, all-cause death and major cardiovascular events. After adjustment for established risk factors including estimated glomerular filtration rate, an elevated SDMA level (4th quartile, >1.38 μmol/L) was associated with renal graft loss; hazard ratio (HR) 5.51 (95% CI 1.95-15.57, p=0.001) compared to the 1st quartile. Similarly,SDMA in the 4th quartile was independently associated with all-cause mortality (HR 4.56 95% CI 2.15-9.71, p<0.001), and there was a strong borderline significant trend for an association with cardiovascular mortality (HR 2.86, 95% CI 0.99-8.21, p=0.051). In stable RTR an elevated SDMA-level is independently associated with increased risk of all-cause mortality and renal graft loss.
The Corrosion Behavior of Ni-Cr-Mo Ternary Alloys in Hot Concentrated Sulfuric Acids with Active Carbon (Part 2) (1997)

The detrimental effect of active carbon on dew point corrosion by carbon-containing sulfuric acids was investigated using Ni-Cr-Mo alloys in 60 and 80% H2SO4 with and without active carbon at 120°C. The addition of active carbon leads to an increase in the dissolution rate of the alloys over a wide potential rage from -900 to 1200mV vs. SCE, along with an increase in current densities of both anodic and cathodic reactions. Active carbon decomposes adsorbed molecular sulfuric acid into active oxygen and sulfur dioxide, the latter of which is identified by gas chromatography. The reaction of active carbon with sulfuric acid also forms sulfonic acids. These reactions lead to a decrease in the intrinsic concentration of sulfuric acid and an increase in the corrosiveness in addition to acceleration of cathodic reaction. Spontaneous passivation in carbon-containing 80% H2SO4 occurs by the formation of a remarkably chromium-enriched passive film containing about 20 cationic % of molybdenum.
Relative viscosity and surface tension of subsoil brines : A case study of Chandan subsoil brine (2000)

Central Salt &amp; Marine Chemicals Research Institute, Bhavnagar-364 002, India <em>Manuscript received 14 October 1998, revised 19 November 1999, accepted 21 February 2000</em> Relative viscosity and surface tension of subsoil brines (underground brines) in the temperature range 30-70° have been evaluated wherein the solar evaporation of these brines takes place for obtaining salt and other byproducts.
Beneficial effect of repeated participation in breast cancer screening upon survival (2023)

For those women who develop breast cancer, regular prior participation in mammography screening confers significantly better survival.
Inhibition of some functions of polymorphonuclear leukocytes by in vitro zinc. (1977)

In granulocytes isolated by dextran sedimentation from dog blood, the O2 consumption, phagocytosis of yeast particles, and E. coli killing were tested in Tris-guffered saline medium with additions of Zn++, Mg++, and other divalent cations and in the presence or absence of plasma. Zn++ inhibited all three cell functions in a concentration-related manner only in the presence of 1.2 mM Mg++. Without Mg++ in the medium the lower concentrations of Zn++ (17 to 67 muM) were stimulatory; 83 muM Zn++ concentration was inhibitory. A close association was found between the inhibitory effect of Zn++ and the actual content of zinc in the cell: (1) the uptake of zinc from the medium was minimal during the first minute, where no Zn++ effect on cell functions was manifest, (2) when zinc-loaded cells with inhibited activity were washed and reincubated for at least 15 minutes in zinc-free medium, almost 95 per cent of the zinc was washed out and cell activity was normalized. This indicated reversibility of the zinc effect, (3) in the presence of increasing concentrations of autologous plasma in the medium, the effect of zinc was proportionally less pronounced and at the same time uptake of zinc by cells was decreased. Of the six divalent cations studied at 50 muM concentration and in the presence of Mg++, only Zn++ was inhibitory, Se and Co were inactive, and Mn and Cu stimulated O2 consumption of latex-activated granulocytes. We conclude that zinc ions, in the presence of Mg++ in the medium, inhibit various functions of dog peripheral granulocytes and this effect is closely associated with zinc uptake by the cells. The effect is reversible and specific for this metal.
Supramolecular structure of helical ribbons self-assembled from a β-sheet peptide (2002)

We have investigated the supramolecular structure of helical ribbons formed during self-assembly of a β-sheet peptide using computer simulation. We tested a wide range of molecular packing geometries consistent with the experimental dimensions to identify the most stable structure, and then systematically changed the helical geometry to investigate its energy landscape. The effect of pH was incorporated by scaling the amount of charge on the side chains based on the electrostatic double layer theory. Our results suggest that these left-handed helical ribbons are comprised of a double β-sheet and that the experimentally measured dimensions correspond to a local energy minimum. Side chain interactions are found to be critical in determining the stability and curvature of the helix. Our approach has general applicability to the study of self-assembled nanostructures from β-sheet peptides where high resolution data are not yet available.
[Extrarenal dialysis in end-stage renal disease]. (2001)

Renal replacement therapy (RRT) has reached its plain maturity. RRT is an unavoidable and banal tool in the armamentorium in the treatment of end stage renal failure (ESRD). It relies on several practical modalities (hemodialysis, peritoneal dialysis and their variants) that permit to satisfy various patient's needs and to ensure the continuity of life support system. Substitution of certain renal endocrine functions (human recombinant erythropoietin, active vitamin D) has brought a new dimension to the treatment of ESRD in improving substantially the quality of life of these patients. Now, if the long-term outcomes confirm the high efficiency of the renal replacement therapies they also draw their limits bounded by the occurrence of a specific pathology of the "long term dialysis" patient. Such dialysis-related pathology is clearly the new challenge for the nephrologist in the XXIst century that should lead to a deep revision of the RRT concept. Optimal treatment of ESRD patients rely clearly on several options that may be used sequentially to solve specific complications and should be part of a complete management program including renal transplantation in patient non contraindicated.
Control Methods of Walk Training System. (1997)

Ambulatory capability results in overall improvement of ability of daily life(ADL)of the elderly. Technical aid of walking ability is a basic solution for an elderly society. The number of the aged in bed will decrease. Walk Training System for the elderly is now under development. It has two parts:a training environment and a patient-support element. The training environment comprises a treadmill and a display. The trainee stands on the treadmill and begins to walk. The belt of the treadmill is driven by active impedance control. The trainee is supported by a two-degree-of-freedom manipulator. The force on the support is determined by the displacement of the trainee from the reference point, so as to correct the posture of the trainee or to support the trainee's weight. The Walk Training System was tested on 30 persons, and its basic function was highly rated.
Aerodynamic Characteristics of Supercritical Outlet Guide Vanes at Low Reynolds Number Conditions (2006)

As a part of an innovative aerodynamic design concept for a single stage low pressure turbine, a high turning outlet guide vane is required to remove the swirl from the hot gas. The airfoil of the vane is a highly loaded compressor airfoil that has to operate at very low Reynolds numbers (Re∼120,000). Recently published numerical design studies and experimental analysis on alternatively designed airfoils showed that blade profiles with an extreme front loaded pressure distribution are advantageous for low Reynolds number conditions. The advantage even holds true for an increased inlet Mach number at which the peak Mach number on the airfoils reaches and exceeds the critical conditions (Mss&gt;1.0). This paper discusses the effect of the inlet Mach number and Reynolds number on the cascade performance for both a controlled diffusion airfoil (CDA) (called baseline) and a numerically optimized front loaded airfoil. The results show that it is advantageous to design the profile with a fairly steep pressure gradient immediately at the front part in order to promote early transition or to prevent too large laminar—even shock induced—separations with the risk of a bubble burst. Profile Mach number distributions and wake traverse data are presented for design and off-design conditions. The discussion of Mach number distributions and boundary layer behavior is supported by numerical results obtained from the blade-to-blade flow solver MISES.
Control of <i>Globodera</i> spp. Using <i>Brassica juncea</i> Seed Meal and Seed Meal Extract (2017)

The eradication program for the potato cyst nematode (PCN), <i>Globodera pallida</i>, in the Northwest of the United States revolves around the use of soil fumigation. Alternative, integrated strategies are needed to continue to battle this invasive nematode. Laboratory, greenhouse, and field experiments were conducted with <i>G. pallida</i> and another cyst nematode found in the United States, <i>Globodera ellingtonae</i>, to evaluate the efficacy of a new formulated <i>Brassica juncea</i> seed meal extract, as well as a traditional <i>B. juncea</i> seed meal, as alternate eradication strategies. This is the first report on the efficacy of <i>B. juncea</i> seed meal extract against plant-parasitic nematodes. Rates of <i>B. juncea</i> seed meal greater than 2.2 t/ha and 4.5 t/ha for <i>G. pallida</i> and <i>G. ellingtonae</i>, respectively, were required for egg hatch suppression, as determined by a potato root diffusate (PRD) bioassay. Reproduction of <i>G. pallida</i> on potato after exposure to <i>B. juncea</i> seed meal at a rate of 2.2 t/ha was also significantly reduced. In the field, 8.9 t/ha <i>B. juncea</i> seed meal almost eliminated egg hatch of <i>G. ellingtonae</i>. Rates needed for <i>Globodera</i> spp. suppression were greatly reduced when using the <i>B. juncea</i> seed meal extract. When compared side-by-side, half as much <i>B. juncea</i> seed meal extract, 1.1 t/ha, was required to suppress <i>G. ellingtonae</i> egg hatch to the same extent as <i>B. juncea</i> seed meal. Exposure of <i>G. pallida</i> to <i>B. juncea</i> seed meal extract at 4.5 t/ha reduced egg hatch by 90% compared with a nonamended control. The ability to reduce the amount of material being applied to soil by using an extract has the potential for integration into a <i>G. pallida</i> eradication program.