gebhart/patrepeval huggingface dataset:
[Review] Development of Sour Syrup “Oligo-Sugar Acid” Based on Maltobionic Acid Using Carbohydrate Oxidase (2020)

グルコースとグルコン酸がα-1,4結合した二糖類であるマルトビオン酸は，糖質と酸としての特徴がハイブリッドしたユニークな性質を持つ糖質である．糖質でありながら甘みは極めて弱く，穏やかな酸味を呈する特性を活かした果汁感付与効果やミネラル成分の不快味のマスキング効果などの用途研究や，マイナスチャージを持つ酸性オリゴ糖ならではのミネラル吸収増進，骨密度改善効果など生理機能を明らかにする一方で，工業化に向けた製法確立においては，マルトース等の二糖類以上の糖質を酸化する性質を有するグルコースオキシダーゼを見いだし，工業生産スペックまでの生産性向上に成功するとともに，酸化反応システムやイオン交換膜を用いた脱塩技術等の工業生産プロセスの開発に成功し，2018年7月よりマルトビオン酸を主成分とする酸性オリゴ糖を食品素材として販売開始した．
[The approaches in the discovery of antidepressants using affective disorder models]. (2003)

With the recent appearance of SSRI and SNRI, medication options with respect to depression have broadened. However, patients displaying clear improvement with existing antidepressants still do not exceed about 60 percent of total patients. New types of therapeutic agent development are currently required. Conditions for the determination of new antidepressants are: 1) instantaneous medications displaying a high level of antidepressant action in the early stages of treatment and 2) medications displaying efficacy with respect to patients that are therapy-resistant. However, drug discovery using new animal models is critical as part of drug development of these types of antidepressants in addition to models used in the past such as the forced swim test. We adopted two animal models (olfactory bulbectomy model and conditioned fear stress (CFS) model) developed for pharmacological evaluation of antidepressants. It has been well known that olfactory bulbectomied rats display extreme emotional response (aggressiveness and anxiety). However the improvement of this response occurs following chronic but not acute antidepressant treatment. Thus, we used this model to evaluate the period of the manifestation of antidepressant action. Mice exhibited a marked suppression of motility when they were returned to the same environment in which they had previously received an electric foot shock. Thus, it is suggested that the CFS stress model may be a useful model for therapy-resistant depression due to the fact that motor suppression is not readily attenuated by antidepressant treatment. In this report, we provide an overview of the approaches in the discovery of new antidepressants using these affective disorder models.
Experimental Studies on Robotic Force Control and Contour Following. 1st Report. Three DOF Robotic Testbed with Force Evaluation System. (1998)

A large class of robotic force control problems, including painting, scraping, and grinding, involve simultaneous force and position control. In many of these aplications, the robot is required to exhibit very high-speed performance while also tolerating unknown or poorly defined constraint specifications. In recent years, some experimental results of robots performing such tasks using hybrid and impedance control strategies have been presented; however, many of these studies neglect the inherent restrictions of actual industrial implementations of force controlled robots. Moreover, evaluation of the performance of the force control algorithms is typically based on data from robot-mounted sensors, rather than workpiece-mounted sensors, the latter being much more important for industrial users of force controlled robots. This paper introduces a high-performance 3 DOF robotic testbed designed specifically to test industrial applications of force control and contour following. The testbed consists of a force sensing table and a 3 DOF manipulator. The manipulator design and control are strongly influenced by practical restrictions arising during application to industrial tasks. Specifications of the developed system, as well as results of preliminary system characterization experiments, are presented in this paper.
Face Verification Across Age Progression Using Discriminative Methods (2009)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Face verification in the presence of age progression is an important problem that has not been widely addressed. In this paper, we study the problem by designing and evaluating discriminative approaches. These directly tackle verification tasks without explicit age modeling, which is a hard problem by itself. First, we find that the gradient orientation, after discarding magnitude information, provides a simple but effective representation for this problem. This representation is further improved when hierarchical information is used, which results in the use of the gradient orientation pyramid (GOP). When combined with a support vector machine GOP demonstrates excellent performance in all our experiments, in comparison with seven different approaches including two commercial systems. Our experiments are conducted on the FGnet dataset and two large passport datasets, one of them being the largest ever reported for recognition tasks. Second, taking advantage of these datasets, we empirically study how age gaps and related issues (including image quality, spectacles, and facial hair) affect recognition algorithms. We found surprisingly that the added difficulty of verification produced by age gaps becomes saturated after the gap is larger than four years, for gaps of up to ten years. In addition, we find that image quality and eyewear present more of a challenge than facial hair. </para>
Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome (2019)

The aortic root is the predominant site for development of aneurysm caused by heterozygous loss-of-function mutations in positive effectors of the transforming growth factor-β (TGF-β) pathway. Using a mouse model of Loeys-Dietz syndrome (LDS) that carries a heterozygous kinase-inactivating mutation in TGF-β receptor I, we found that the effects of this mutation depend on the lineage of origin of vascular smooth muscle cells (VSMCs). Secondary heart field-derived (SHF-derived), but not neighboring cardiac neural crest-derived (CNC-derived), VSMCs showed impaired Smad2/3 activation in response to TGF-β, increased expression of angiotensin II (AngII) type 1 receptor (Agtr1a), enhanced responsiveness to AngII, and higher expression of TGF-β ligands. The preserved TGF-β signaling potential in CNC-derived VSMCs associated, in vivo, with increased Smad2/3 phosphorylation. CNC-, but not SHF-specific, deletion of Smad2 preserved aortic wall architecture and reduced aortic dilation in this mouse model of LDS. Taken together, these data suggest that aortic root aneurysm predisposition in this LDS mouse model depends both on defective Smad signaling in SHF-derived VSMCs and excessive Smad signaling in CNC-derived VSMCs. This work highlights the importance of considering the regional microenvironment and specifically lineage-dependent variation in the vulnerability to mutations in the development and testing of pathogenic models for aortic aneurysm.
Packaging of Proteins into Viral Capsids and their Activation (2008)

Extended abstract of a paper presented at Microscopy and Microanalysis 2008 in Albuquerque, New Mexico, USA, August 3 – August 7, 2008
Denoising Stimulated Raman Spectroscopic Images by Total Variation Minimization (2015)

High-speed coherent Raman scattering imaging is opening a new avenue to unveiling the cellular machinery by visualizing the spatio-temporal dynamics of target molecules or intracellular organelles. By extracting signals from the laser at MHz modulation frequency, current stimulated Raman scattering (SRS) microscopy has reached shot noise limited detection sensitivity. The laser-based local oscillator in SRS microscopy not only generates high levels of signal, but also delivers a large shot noise which degrades image quality and spectral fidelity. Here, we demonstrate a denoising algorithm that removes the noise in both spatial and spectral domains by total variation minimization. The signal-to-noise ratio of SRS spectroscopic images was improved by up to 57 times for diluted dimethyl sulfoxide solutions and by 15 times for biological tissues. Weak Raman peaks of target molecules originally buried in the noise were unraveled. Coupling the denoising algorithm with multivariate curve resolution allowed discrimination of fat stores from protein-rich organelles in <i>C. elegans</i>. Together, our method significantly improved detection sensitivity without frame averaging, which can be useful for <i>in vivo</i> spectroscopic imaging.
High power picosecond vortex laser based on a large-mode-area fiber amplifier (2009)

We present the production of picosecond vortex pulses from a stressed large-mode-area fiber amplifier for the first time. 8.5 W picosecond output with a peak power of approximately 12.5 kW was obtained at a pump power of 29 W. 2009 Optical Society of America.
Synthesis of self‐healing supramolecular rubbers from fatty acid derivatives, diethylene triamine, and urea (2008)

Abstract We describe the synthesis of supramolecular self‐healing elastomers from vegetable oil fatty acid derivatives, diethylene triamine, and urea. Our strategy to obtain materials that are self‐healing but do not flow relies on the use of a wide molecular distribution of randomly branched oligomers equipped with self‐complementary and complementary hydrogen bonding groups. We prepared such oligomers with a two steps procedure. In the first step, diethylene triamine was condensed with dimer acids. In the second step, the oligomers obtained were allowed to react with urea. The molecules were characterized by NMR and IR spectroscopies and Monte‐Carlo simulations were used to analyze the molecular size distribution. The sensitivity to small variations of the experimental conditions has been examined and the robustness of the synthetic procedure optimized. © 2008 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 7925–7936, 2008
Supramolecular Ligands for Histone Tails by Employing a Multivalent Display of Trisulfonated Calix[4]arenes (2015)

Post-translational modification of histone tails plays critical roles in gene regulation. Thus, molecules recognizing histone tails and controlling their epigenetic modification are desirable as biochemical tools to elucidate regulatory mechanisms. There are, however, only a few synthetic ligands that bind to histone tails with substantial affinity. We report CA2 and CA3, which exhibited sub-micromolar affinity to histone tails (especially tails with a trimethylated lysine). Multivalent display of trisulfonated calix[4]arene was important for strong binding. CA2 was applicable not only to synthetic tail peptides but also to endogenous histone proteins, and was successfully used to pull-down endogenous histones from nuclear extract. These findings indicate the utility of these supramolecular ligands as biochemical tools for studying chromatin regulator protein and as a targeting motif in ligand-directed catalysis to control epigenetic modifications.
Amphotericin B: 50 Years of Chemistry and Biochemistry (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Cellulosic Materials: Sustainable Surface Engineering of Lignocellulose and Cellulose by Synergistic Combination of Metal‐Free Catalysis and Polyelectrolyte Complexes (Global Challenges 7/2019) (2019)

In article number 1900018 by Armando Cordova and co-workers, the novel combination of metal-free catalysis and renewable polyelectrolyte complexes leads to synergistic surface engineering of lignocellulose and cellulose fibers derived from wood. This sustainable strategy allows for improvement and introduction of important properties such as strength (up to 100% in Z-strength), water resistance, and fluorescence to the renewable fibers and cellulosic materials under eco-friendly conditions.
SnTe Nanocrystals: A New Example of Narrow‐Gap Semiconductor Quantum Dots. (2007)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Frequency domain modeling of aided GPS with application to high-speed vehicle navigation systems (2002)

Position information obtained from standard GPS receivers is known to be corrupted with coloured (time-correlated) noise. To make effective use of GPS information in a navigation system it is essential to model this coloured noise and to incorporate additional sensing to de-correlate and eliminate its effect. In this paper frequency domain techniques are employed to generate a model for GPS noise sources. This model shows clearly what type and combination of additional sensor information is necessary to de-correlate GPS errors and to make best use of position information in navigation tasks. The frequency-domain methodology proposed has wider application in the design of sensor suites for high-performance navigation systems. Experimental results are presented demonstrating the method in fusing standard GPS latitude and longitude information with information from a velocity sensor.
Application of Shaping Technique With Turbo Coset Codes (2007)

This paper presents a method for the combined turbo code and quadratic-amplitude modulation using coset coding. It also presents a fixed-rate shaping algorithm offering lower complexity as compared to all relevant methods reported in the literature. A symbol-based turbo code acting on symbols of size 4 is used to select a coset along each 1D subconstellation (using the partition Z/4Z). The proposed coset coding method satisfies the conditions for the separability of shaping and coding, and, consequently, can be easily integrated with the shaping algorithm. Numerical results are presented for an additive white Gaussian noise channel. The proposed coding-shaping algorithm offers the best performance reported in the literature, enjoys very low complexity, can be easily scaled to accommodate different bit rates and spectral efficiencies, and does not suffer from an early error floor, as observed in many other related works.
Electrochemical oxidation of nickel(111)c(4.times.2)-carbon monoxide in alkaline electrolytes (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical oxidation of nickel(111)c(4.times.2)-carbon monoxide in alkaline electrolytesKuilong Wang, Gary S. Chottiner, and Daniel A. SchersonCite this: J. Phys. Chem. 1992, 96, 16, 6742–6744Publication Date (Print):August 1, 1992Publication History Published online1 May 2002Published inissue 1 August 1992https://doi.org/10.1021/j100195a039Request reuse permissionsArticle Views66Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (426 KB) Get e-Alerts
Synthesis of Boron Nitride Coating on Carbon Nanotubes (2004)

A method to synthesize boron nitride coating on the surface of carbon nanotubes (nanofibers) without damaging the tube walls has been developed. A reaction between boric acid and ammonia was performed at moderate temperatures on the surface of carbon nanotubes to form boron nitride (BN) coatings. The surface structure of the carbon nanotubes significantly influences the morphology of the boron nitride coating. If the surface of the tubes is free of defects, highly crystallized insulating BN nanotubes can encapsulate carbon nanotubes. On the surface of carbon nanotubes with disordered wall structure, a polycrystalline BN sheath was produced.
Elimination of Shock Associated Noise in Supersonic Jets by Destructive Wave Interference (2018)

A novel application of fluidic injection was developed to investigate and understand the effects of discrete fluidic injection internal to the jet nozzle. Various injection locations, angles, and conditions were studied resulting in unique acoustic behavior and flow field modifications. For most conditions the acoustics are relatively unaffected or increased, but for very specific conditions noise was drastically decreased. For optimized conditions the shock noise was completely eliminated and in other cases a jet instability was generated that significantly decreased high frequency noise. Measurements of the velocity field indicated that shock interaction due to shocks from the injection jet interact with the primary jet shocks, and significantly reduce the shock strength, attributing massive shock noise reduction. Validation of the experimental results was achieved with LES, which provided additional insight into the shock suppression due to resolution of the flowfield internal to the nozzle. Optimal injection parameters resulted in reduction of OASPL of -7 dB at the upstream and downstream angles simultaneously through a combination of shock disruption and streamwise vorticity introduction. A new mechanism of supersonic jet noise reduction, destructive interference of the shock structure in the jet is reported.
Thermal and Mechanical Loading in the Combustion Bowl Region of Light Vehicle Diesel AlSiCuNiMg Pistons; Reviewed with Emphasis on Advanced Finite Element Analysis and Instrumented Engine Testing Techniques. (2012)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The continued rise in specific power output and thermal loading characteristics of the modern automotive diesel engine provides piston engineers and scientists with the challenge of continually improving their knowledge and understanding of thermomechanical loading and durability factors. The capacity to predict thermomechanical fatigue (TMF) effects with confidence at a pre-engineering stage will improve the technology selection and component design processes leading to a more efficient development phase.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;This paper reviews how the use of advanced instrumented engine testing and finite element modeling (FEM) techniques are helping engineers improve their understanding of transient thermal load regimes in automotive AlSiCuNiMg pistons. The investigations offer insightful observation of transient measured piston temperatures in the high and low frequency operating regimes for two diesel engine platforms. The initial section of the paper provides an introduction to diesel piston combustion bowl loading and the simulation techniques presently in use and being developed to enhance the capability of time dependent thermomechanical deformation and fatigue modeling. Concluding this section is a similar synopsis of key issues relevant to the characterisation and testing of ‘engine-like’ loading for AlSiCuNiMg piston alloys.&lt;/div&gt;&lt;/div&gt;
Supplementary Table S4 from Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04) (2023)

&lt;p&gt;Genomics data&lt;/p&gt;
The Stability and Continuity Behavior of the Spectral Factorization in the Wiener Algebra With Applications in Wiener Filtering (2008)

This paper investigates the stability and the continuity behavior of the spectral factorization and of the Wiener filter in the bounded-input bounded-output (BIBO) stability norm. It shows that if the minimum of the given spectra becomes not smaller than half its norm, there exist uniform upper bounds on the stability norm of the spectral factor and Wiener filter. If on the other hand, the minimum becomes smaller than a quarter of its norm, no such upper bounds can exist. In the second part, it is shown that every BIBO-stable spectral density is a continuity point of the spectral factorization. From this, it is derived that the Wiener filter always depends continuously on the data in the BIBO-norm. These results are compared with energy stable systems. It turns out that every continuous spectrum is a discontinuous point for the spectral factorization in the energy norm. It follows that the Wiener filter depends not continuous on the data in this norm.
Synaptic Connections Between Spiny Neurons of the Direct and Indirect Pathways in the Neostriatum of the Rat: Evidence from Dopamine Receptor and Neuropeptide Immunostaining (1996)

spiny neurons, direct pathway,indirect pathways, rat neostriatum
Breaking of Symmetry in Graphene Growth on Metal Substrates (2015)

In graphene growth, island symmetry can become lower than the intrinsic symmetries of both graphene and the substrate. First-principles calculations and Monte Carlo modeling explain the shapes observed in our experiments and earlier studies for various metal surface symmetries. For equilibrium shape, edge energy variations δE manifest in distorted hexagons with different ground-state edge structures. In growth or nucleation, energy variation enters exponentially as ∼e(δE/k(B)T), strongly amplifying the symmetry breaking, up to completely changing the shapes to triangular, ribbonlike, or rhombic.
Multicore EDF Optimized for Remotely Pumped Amplification System over Multicore Fiber (2013)

Multicore EDF for a remotely pumped amplification system over an MCF have been designed and fabricated. The amplification characteristics of the fabricated MC-EDF were confirmed by assembling the MC-EDF as an EDFA.
Update on Current Technologies for Deep Brain Stimulation in Parkinson’s Disease (2020)

Deep brain stimulation (DBS) is becoming increasingly central in the treatment of patients with Parkinson's disease and other movement disorders. Recent developments in DBS lead and implantable pulse generator design provide increased flexibility for programming, potentially improving the therapeutic benefit of stimulation. Directional DBS leads may increase the therapeutic window of stimulation by providing a means of avoiding current spread to structures that might give rise to stimulation-related side effects. Similarly, control of current to individual contacts on a DBS lead allows for shaping of the electric field produced between multiple active contacts. The following review aims to describe the recent developments in DBS system technology and the features of each commercially available DBS system. The advantages of each system are reviewed, and general considerations for choosing the most appropriate system are discussed.
Relationship between composition, rheological and swelling properties of alkali-silica gels produced in cemented waste packages (2018)

ACTI
A Community’s Awareness and Perceptions of Genomic Medicine (2009)

While individuals recognized that diseases run in families, personal experience was a driving factor in participants' level of knowledge. Many expressed optimism about genomic medicine. However, the lack of depth in responses and their misconceptions reflect a deficiency of knowledge, which along with their personal, moral, and global concerns could impede acceptance and utilization of genomic medicine. Many community members are receptive to learning more about genomic medicine, and many of their concerns and misconceptions can be addressed through a well designed education strategy.