gebhart/patrepeval huggingface dataset:
Flying Rebots: First Results on an Autonomous UAV-Based LTE Relay Using Open Airinterface (2018)

In this paper we introduce the design of the “Rebot” (Relaying Robot) for future wireless networks. The Rebot concept is first of its kind in providing enhanced end-to-end LTE connectivity to ground users from a fixed base station via a flying relay which is enabled with an autonomous placement algorithm. The Rebot that we have built is a customized integrated UAV relay and its communication layer is based on OpenAirInterface. The ground user carries an off-the-shelf commercial LTE mobile terminal. We also present a placement algorithm that updates the UAV position in real time based on user location and wireless channel conditions so as to maximize the throughput at all times. The experimental results show throughput gains by using this UAV relay and also illustrate the learning/tracking behavior of the Rebot.
[Experience of implantation of prefitted Palmaz Corinthian stents]. (2003)

We report our recent experience with the Palmaz Corinthian stent in children. Since 1/10/01 to 1/11/02 we implanted 18 Palmaz Corinthian stents in 12 children. Median age and weight of patients were 5.6 years (range 0.25-13) and 17.9 kg (range 3-36), respectively. Primary diagnosis were: pulmonary atresia with ventricular septal defect (n = 7), complex transposition of the great arteries (n = 2) and others (n = 3). Indications to stent implantation were: pulmonary branches stenosis (n = 9), stenosis of the ductus arteriosus (n = 1), stenosis of systemic veins (n = 2). All stents were pre-mounted and co-axially advanced over a standard guidewire across the stenotic site, using a 6F short introducer. Stent deployment was performed by hand inflation of the balloon. Final angiography confirmed correct positioning and ruled out complications. Median fluoroscopy time was 18 minutes (range 12-56). All stents reached their nominal diameter; 2 were post-dilated to 125 and 150%. No procedural complications occurred. Despite the impossibility of distal injection, stent positioning was always correct. In conclusion, due to the availability of pre-mounted stents, and the need of short 6F sheaths, the use of the Palmaz Corinthian stent in children is relatively simple. Primary results are generally good in terms of adequate delivery and absence of complications. However, the impossibility of distal injection makes more difficult the choice of the deployment site. Due to the limited possibility of over-dilation, the use of this stent has to be limited to the stenosis of peripheral pulmonary branches or to lesions that can be surgically treated during further surgical procedures.
Second harmonic generation by electro-poling in femtosecond laser induced micro-structured silver containing glass (2009)

Laser structuring and electro-poling has been carried out in silver containing glasses. The second-order NLO response after direct laser patterning has been investigated in the scope of developing further practical use of the material.
Molecular investigation if the rat jejunal active nucleoside transport protein rCNT1 (1998)

Active, sodium-dependent nucleoside transport systems have been kinetically described in a number of different mammalian tissues. The recent cloning of several active, mammalian nucleoside transporters belonging to a novel gene family has provided an opportunity to examine both the structure/function relationships and the tissue distributions of these proteins in detail, and thus to elucidate their physiological roles. The first of these transporters to be cloned was rCNT1, a protein&#13;\nfrom rat jejunal epithelium which exhibits pyrimidine-selective, cit-type transport activity. The present study involved a bi-directional approach to the investigation of&#13;\nthis protein by the analysis of its distribution in rat tissues at both the cellular and subcellular levels, in addition to structural investigation of rCNT1 by protein&#13;\nchemistry and gene manipulation techniques.&#13;\n&#13;\nA model originally proposed for the topology of this protein, based largely upon hydropathy analysis of its sequence, suggested that the N- and C-terminal hydrophilic regions of this protein were cytoplasmic. However the present study has shown, from the effect of endoglycosidase F treatment of the protein expressed in xenopus oocytes, that the C-terminal hydrophilic domain of the protein is N-glycosylated and so must in fact be extracellular. Furthermore, mutagenesis of rCNT1 cDNA allowed for the production of an aglyco-rCNT1 mutant into which novel glycosylation sites were introduced as a means of probing topology. Evidence from this mutagenesis has indicated that the N-terminus of rCNT1 is cytoplasmic, therefore suggesting that rCNTI exists in the lipid bilayer with thirteen putative transmembrane domains and not fourteen as originally proposed. Analysis of the protein sequence using predictive algorithms suggests that the originally-predicted&#13;\ntransmembrane helix 6 is in fact extramembranous.&#13;\n&#13;\nAnalysis of the distribution of rCNT1 in rat tissues by immunoblotting has revealed that this active transporter is more widespread than originally suggested by the results of Northern blotting experiments. Moreover, it has been possible by immunocytochemical analysis not only to identify the cell types in which rCNT1 is expressed but also to show that its distribution is restricted to certain domains of the plasma membrane. rCNT1 in the jejunum and kidney has been localized at the intestinal and renal brush-borders respectively. While in the liver it is abundant in the bile canalicular membranes. This location is consistent with roles for the concentrative transporter in the absorption of nucleosides from the diet or their&#13;\nsalvage from the extracellular breakdown of nucleotides. Unexpectedly, rCNT1 also appears to be abundant in the hippocampus, and in the actively dividing seminiferous&#13;\nepithelium of the testis. Furthermore, its presence has also been suggested in cardiac muscle, skeletal muscle and the spleen, although these observations await further&#13;\nconfirmation.
Endothelial Jagged-1 Is Necessary for Homeostatic and Regenerative Hematopoiesis (2013)

The bone marrow (BM) microenvironment is composed of multiple niche cells that, by producing paracrine factors, maintain and regenerate the hematopoietic stem cell (HSC) pool (Morrison and Spradling, 2008). We have previously demonstrated that endothelial cells support the proper regeneration of the hematopoietic system following myeloablation (Butler et al., 2010; Hooper et al., 2009; Kobayashi et al., 2010). Here, we demonstrate that expression of the angiocrine factor Jagged-1, supplied by the BM vascular niche, regulates homeostatic and regenerative hematopoiesis through a Notch-dependent mechanism. Conditional deletion of Jagged-1 in endothelial cells (Jag1((ECKO)) mice) results in a profound decrease in hematopoiesis and premature exhaustion of the adult HSC pool, whereas quantification and functional assays demonstrate that loss of Jagged-1 does not perturb vascular or mesenchymal compartments. Taken together, these data demonstrate that the instructive function of endothelial-specific Jagged-1 is required to support the self-renewal and regenerative capacity of HSCs in the adult BM vascular niche.
Re-Use of Caco-2 Monolayers in Permeability Assays—Validation Regarding Cell Monolayer Integrity (2021)

Caco-2 monolayers are a common in vitro model used to evaluate human intestinal absorption. The reference protocol requires 21 days post-seeding to establish a stable and confluent cell monolayer, which is used in a single permeability assay during the period of monolayer stability (up to day 30). In this work, we characterize variations in the tightness of the cell monolayer over the stable time interval and evaluate the conditions required for their re-use in permeability assays. The monolayer integrity was assessed through TEER measurements and permeability of the paracellular marker Lucifer Yellow (LY), complemented with nuclei and ZO-1 staining for morphological studies and the presence of tight junctions. Over 150 permeability assays were performed, which showed that manipulation of the cell monolayer in the permeability assay may contribute significantly to the flux of LY, leading to <i>P</i><sub>app</sub> values that are dependent on the sampling duration. The assay also leads to a small decrease in the cell monolayer TEER, which is fully recovered when cell monolayers are incubated with culture media for two full days. When this procedure is followed, the cell monolayers may be used for permeability assays on days 22, 25, and 28, triplicating the throughput of this important assay.
Effects of 20-hydroxyecdysone on UVB-induced photoaging in hairless mice (2023)

We recently reported that exposure of skin to ultraviolet B (UVB) irradiation for 2 weeks induces stress and accelerates skin aging. Interestingly, aldosterone synthase is known to be crucial in generating UVB-induced stress-related responses, suggesting that drugs that regulate its activity can be used as skin antiaging agents. Through extensive drug screening, we have identified 20-hydroxyecdysone (20E), a steroidal prohormone secreted by the prothoracic glands of insects, as a potent inhibitor of UVB-induced aging. Although 20E has been shown to exert antistress and anti-collagenase effects in vitro, its effects in vivo remain unexplored. Furthermore, the pharmacological and physiological effects of 20E on UVB-mediated photoaging are poorly understood. Therefore, in this study, we investigated the effects of 20E on aldosterone synthase and UVB-induced photoaging and skin lesions in hairless mice, focusing on the stress-related hypothalamic-pituitary-adrenal axis. We confirmed that 20E inhibited aldosterone synthase and reduced corticosterone levels. When applied to a UV-induced skin aging animal model, it ameliorated UV-induced stress and protected against the decrease in collagen levels. Importantly, when the aldosterone synthase inhibitor osilodrostat, an FDA-approved drug, was applied to the UV-induced skin aging model, the stress-reducing and antiaging effects of 20E were not observed. Thus, we conclude that 20E inhibits UVB-induced skin aging by blocking aldosterone synthase and is a potential candidate to prevent skin aging.
Autism and genetics: Clinical approach and association study with two markers of HRAS gene (1995)

Twin studies and familial aggregation studies indicate that genetic factors could play a role in infantile autism. In an earlier study, we identified a possible positive association between autism and a c-Harvey-ras (HRAS) oncogene marker at the 3' end of the coding region. In an attempt to confirm this finding, we studied a larger population, well-characterized clinically and genetically. We report a positive association between autism and two HRAS markers, the 3' marker used in the initial study and an additional marker in exon 1.
Tree-to-Sequence Attentional Neural Machine Translation (2016)

Most of the existing Neural Machine Translation (NMT) models focus on the conversion of sequential data and do not directly use syntactic information. We propose a novel end-to-end syntactic NMT model, extending a sequenceto-sequence model with the source-side phrase structure. Our model has an attention mechanism that enables the decoder to generate a translated word while softly aligning it with phrases as well as words of the source sentence. Experimental results on the WAT'15 Englishto-Japanese dataset demonstrate that our proposed model considerably outperforms sequence-to-sequence attentional NMT models and compares favorably with the state-of-the-art tree-to-string SMT system.
Restoring unfavorably positioned implants in anterior maxilla: case report. (2014)

This article describes a clinical case involving a unique solution to restoring implants placed in an unfavorable, labial location in the anterior maxilla. Background information is provided with regard to avoiding compromised situations from the outset, as well as a discussion of issues of restorability, with an emphasis on dental implants. Different treatment options are explored. To complete the case presented, a custom cast framework resembling traditional veneer preparations was selected, with porcelain veneers to cover abutment screw access channels.
Lymphocyte Phospho-Ser-9-GSK-3β/Total GSK-3β Protein Levels Ratio Is Not Affected by Chronic Lithium or Valproate Treatment in Euthymic Patients With Bipolar Disorder (2017)

The data do not support the concept that in vivo, during chronic treatment of bipolar illness, GSK-3β is inhibited either by lithium or by VPA.
Selective tuning of cortical sound‐feature processing by language experience (2006)

In 'quantity-languages', such as Japanese or Finnish, sound duration is linguistically relevant. We showed that quantity-language speakers were superior to speakers of a non-quantity language in discriminating the duration of even non-speech sounds. In contrast, there was no group difference in the discrimination of sound frequency. This result, obtained both by behavioural and neural indices at attentive and automatic levels of processing, indicates precise feature-specific tuning of the auditory-cortex functions by the mother tongue.
Skyline (2015)

This paper introduces Skyline, a user experience prototyping platform for automotive, developed in Intel Labs to enable rapid iterative development of in-vehicle experiences. The paper describes the hardware and software components of Skyline. It highlights the flexibility of the interior HMI configuration and the accessibility of the development platform, based on open source Web technologies such as JavaScript, CSS, Node.js and MQTT. The paper steps through the development and user testing processes for a cockpit experience with Skyline, illustrating the benefits of capturing early qualitative user feedback as support for rapid prototyping. Finally, the paper outlines the potential benefits of high fidelity assets developed on the platform for both industry and academia, and the enormous value that documented user experience HMI assets can have for in-vehicle feature productization and research.
Insulin increases the cell surface concentration of α2-macroglobulin receptors in 3T3-L1 adipocytes (1989)

The present study shows that insulin causes an increase in the binding of alpha 2-macroglobulin (alpha 2M) to 3T3-L1 adipocytes. Scatchard analysis of the binding at 4 degrees C indicated an approximate 2-fold increase in the number of alpha 2M binding sites, with no change in the apparent affinity of the receptor. In addition, a 2-3-fold increase in the binding of monoclonal antibody 2C6, which recognizes a component of the alpha 2M receptor, was found in cells treated at 37 degrees C with insulin and then KCN to inhibit receptor endocytosis. An increased cellular accumulation of alpha 2M was also observed in response to insulin. Interestingly, the increase in the rate of accumulation of alpha 2M was significantly smaller than the increase in the number of alpha 2M receptors on the cell surface, suggesting that the rate of ligand internalization or subsequent processing is altered in response to insulin. Ultrastructural analysis of the internalization pathway of the alpha 2M receptor was performed using colloidal gold-coupled 2C6 monoclonal antibody. Control cells incubated for 20 min at 37 degrees C with the gold-conjugated antibody displayed 40% of cellular gold particles on the cell surface and 60% within intracellular structures. In insulin-treated cells this proportion was reversed, with 64% of the particles being found on the cell surface, and only 36% within intracellular structures. Significant differences in the distribution of gold particles among intracellular structures were detected between control and insulin-treated cells. Whereas in control cells, 18% of the total cellular gold particles internalized into tubulovesicles and multivesicular bodies, in insulin-treated cells only 3% of the gold particles were found within these structures. These data indicate that the movement of this receptor between endocytic compartments is altered in response to insulin, and suggest that the effect of insulin to increase the cell surface concentration of alpha 2M receptors and the accumulation of alpha 2M is due, at least in part, to alterations in the endocytic portion of the receptor recycling pathway.
Asymmetrically Coordinated CoB<sub>1</sub>N<sub>3</sub> Moieties for Selective Generation of High‐Valence Co‐Oxo Species via Coupled Electron–Proton Transfer in Fenton‐like Reactions (2023)

High-valence metal species generated in peroxymonosulfate (PMS)-based Fenton-like processes are promising candidates for selective degradation of contaminants in water, the formation of which necessitates the cleavage of OH and OO bonds as well as efficient electron transfer. However, the high dissociation energy of OH bond makes its cleavage quite challenging, largely hampering the selective generation of reactive oxygen species. Herein, an asymmetrical configuration characterized by a single cobalt atom coordinated with boron and nitrogen (CoB<sub>1</sub> N<sub>3</sub> ) is established to offer a strong local electric field, upon which the cleavage of OH bond is thermodynamically favored via a promoted coupled electron-proton transfer process, which serves an essential step to further allow OO bond cleavage and efficient electron transfer. Accordingly, the selective formation of Co(IV)O in a single-atom Co/PMS system enables highly efficient removal performance toward various organic pollutants. The proposed strategy also holds true in other heteroatom doping systems to configure asymmetric coordination, thus paving alternative pathways for specific reactive species conversion by rationalized design of catalysts at atomic level toward environmental applications and more.
Weight status and dietary intake determine serum leptin concentrations in pregnant and lactating women and their infants (2013)

Leptin regulates energy homeostasis and immune and metabolic functions. Highly elevated leptin concentrations during pregnancy may be associated with aberrations in maternal metabolism and long-term health consequences both in women and children. The objective of the present study was to evaluate whether dietary counselling, probiotic supplementation, maternal characteristics or dietary intake during pregnancy has an impact on serum leptin concentrations in women, cord blood or in children. A total of 256 pregnant women were randomised to a control group (n 85) or to receive dietary counselling with probiotics (n 85) or placebo (n 86). Dietary counselling aimed at affecting the type of fat used and to increase the amount of fibre in the women's diet. Women's dietary intake and serum leptin concentrations were analysed at the first and third trimesters of pregnancy and at 1 month postpartum. Furthermore, leptin concentrations were measured from the cord blood and from children's serum at 1 and 6 months of age. Weight status and dietary composition were the key determinants of leptin concentrations. Specifically, high dietary fibre and low SFA intakes were related to low serum leptin concentrations in women. Female sex and birth weight were associated with higher infant leptin, whereas cord blood leptin was additionally affected by maternal leptin concentration and protein intake. Probiotics or dietary counselling did not affect leptin concentrations. Weight control to recommended levels and modification of diet towards higher fibre and lower SFA intakes during pregnancy may through leptin concentrations provide health benefits to both women and children.
General Data Protection Regulation Complied Blockchain Architecture for Personally Identifiable Information Management (2018)

Surveillance and secrecy breaching incidents of users' privacy questioned the current third-parties data collection procedure. Massive amounts of Personally Identifiable Information (PII) are being exploited due to malpractice, identity theft, spamming, phishing and cyber-espionage. A large amount of data flow from users to enterprises for data-driven market analysis and prediction. Consequently, it is tough to track the flow and genuineness of PII. Blockchain technology, an ‘immutable’ distributed ledger which can efficaciously track PII exchange, store, and distribution. In contrast, ongoing EU General Data Protection Regulation (GDPR) demands ‘right to forget’ and ‘should be erasable’ rights. However, this paper proposes an off-chain Blockchain architecture which uses both local database and distributed ledgers to preserve a trustable PII life cycle. Considering the key factors of GDPR, prevailing Blockchain architecture were modified and a prototype was created to validate our proposed architecture using multichain 2.0. Proposed architecture stores PII and Non-PII physically separated location. Finally, with proposed architecture user will realm privacy and rigidity of Blockchain along with the privacy regulation of GDPR. Validation is done by comparing proposed system with existing methodology from technical aspects, future research scopes is also well advocated.
Correlation between Mechanical Properties and Porosity Distribution of A356 in Gravity Die Casting and Low Pressure Die Casting (2012)

Gravity die casting (GDC) and low pressure die casting (LPDC) methods were used to compare the mechanical properties and porosity distribution in a 5-step mould design. Commercially available A356 alloy was used for the experiments. Ar and Ar+H 2 mixture were used to achieve two different hydrogen levels, i.e. 0,1 and 0,2 ml/100g Al, respectively. Although the porosity level was lower in LPDC, the tensile properties were lower than GDC due to the fact that LPDC melt had 50 mm bifilm index, whereas GDC melt had 20 mm. This investigation has shown that the metal quality has a larger effect over the mechanical properties than the porosity content.
Analyses of steam distillates and aqueous extracts of smokeless tobacco (1989)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAnalyses of steam distillates and aqueous extracts of smokeless tobaccoEdmond J. LaVoie, Patricia Tucciarone, Mark Kagan, John D. Adams, and Dietrich HoffmannCite this: J. Agric. Food Chem. 1989, 37, 1, 154–157Publication Date (Print):January 1, 1989Publication History Published online1 May 2002Published inissue 1 January 1989https://pubs.acs.org/doi/10.1021/jf00085a036https://doi.org/10.1021/jf00085a036research-articleACS PublicationsRequest reuse permissionsArticle Views91Altmetric-Citations6LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Quantitative synthesis of protein–DNA conjugates with 1 : 1 stoichiometry (2018)

We describe here a binding-facilitated reaction strategy, enabling quantitative conjugation of DNA to native proteins with a desirable 1 : 1 stoichiometry. The technique takes advantage of the iterative affinity interaction and covalent binding processes to achieve complete conjugation. The complete conjugation obviates the need for separation of the protein-DNA conjugates as required by other DNA-protein conjugation methods.