gebhart/patrepeval huggingface dataset:
Abstract 5512: TIC10/ONC201 in combination with ceralasertib exhibits potent synergy in high grade serous ovarian cancer cells (2023)

Abstract High-grade serous ovarian cancer (HGSOC) is the most common and malignant form of ovarian cancer. Although patients with HGSOC are likely to respond to treatment, it is common for the cancer to recur and become resistant to treatment, therefore there is a need to develop new targets and novel combinations to increase patient survival rates. ATRi’s (Ataxia telangiectasia and Rad3 related inhibitors) have shown efficacy in HGSOC. Considering ATRi’s have shown moderate efficacy as a single treatment in HGSOC patients, we hypothesized that combining ATRi’s with ONC201 would enhance efficacy. ONC201 is a pro-apoptotic TRAIL-inducing compound that activates the integrated stress response and inactivates the Akt pathway which is upregulated in over 70% of HGSOC. Inactivation of the Akt pathway may result in a synergistic effect that could be translated for use in patients with HGSOC. Three HGSOC cell lines were treated with the novel drug combination of ceralasertib (ATRi) and ONC201 and CellTiterGLO viability assays were performed after 72 hours to evaluate the synergistic effect of combination treatment. Western blots were performed to investigate the synergistic effect of combination treatment on the Akt pathway as well as expression of the cellular metabolic stress protein ATF4. Cytokine profiling using the Luminex 200 technology was performed to study treatment-induced changes in the tumor microenvironment. Cell viability after ceralasertib and ONC201 combination treatment showed synergy in HGSOC cell lines (OVCAR3, KURAMOCHI, TOV21G). In TOV21G cell line, combination studies of ONC201 and ceralasertib calculated by compusyn software demonstrated a synergistic effect of both drugs, Combination indexes below one were observed at concentration of 0.008-2 μM of ceralasertib with 0.31-5 μM of ONC201 with the best combination index of 0.65. We similarly observed synergy in the two other cell line between ONC201 and ceralasertib. Western blotting showed reduction in total Akt and Erk expression and an increase in ATF4, consistent with the observed synergetic effect of ceralasertib and ONC201 combination. Our ongoing studies are exploring potential mechanisms of synergy between ceralasertib and ONC201 and effects on immune–mediated killing of HGSOC cells. Our results suggest a rational and potentially effective novel therapy combination of ATRi ceralasertib and ONC201 that maybe further developed for HGSOC. Citation Format: Maryam Ghandali, Kadir Mert Selvi, Kelsey E. Huntington, Andrew George, Anna Ochsner, Benedito A. Carneiro, Donn S. Dizon, Wafik S. El-Deiry. TIC10/ONC201 in combination with ceralasertib exhibits potent synergy in high grade serous ovarian cancer cells. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5512.
Prostaglandin E2 desensitizes cAMP-mediated pepsinogen secretion in chief cells (1991)

To evaluate whether pretreatment with prostaglandin E2 (PGE2) could desensitize pepsinogen secretion in chief cells from guinea pig, chief cells were pretreated with 10 microM PGE2 for up to 30 min. Desensitization of subsequent PGE2-stimulated secretion was maximal after 15 min, averaging only 29 +/- 9% (SE) of pepsinogen secretion in control cells stimulated with 10 microM PGE2. Desensitization was half-maximal with 30 nM PGE2. PGE2 pretreatment at 4 degrees C did not cause desensitization. In cells pretreated with 10 microM PGE2 for 15 min and then given 60 min to recover, responsiveness increased to 79 +/- 7% of that for control cells stimulated with PGE2. Thus the desensitization was reversible. Pretreatment with PGD2 and PGF2a did not alter subsequent PGE2-mediated secretion. PGE2-induced desensitization was heterologous but mediator specific because pepsinogen secretion was reduced in response to adenosine 3',5'-cyclic monophosphate (cAMP)-mediated agents (secretin and vasoactive intestinal peptide) but not Ca(2+)-mediated agents (CCK-8, gastrin, or carbachol). Pretreating chief cells with 10 microM PGE2 did not significantly alter cAMP generation in response to PGE2, secretin, or 3-isobutyl-1-methylxanthine, suggesting that desensitization was not mediated by an alteration in the receptor-coupled adenylate cyclase system. Because PGE2 pretreatment also desensitized pepsinogen secretion induced by the synthetic cAMP analogues 8-BrcAMP and 2'-O-monobutyryl-8-BrcAMP, it is likely that the ability of PGE2 to desensitize pepsinogen secretion in chief cells isolated from guinea pig is due to a mechanism distal to generation of cAMP.
Prevalence of Sequence Variants in the RAS-Mitogen Activated Protein Kinase Signaling Pathway in Pre-Adolescent Children With Hypertrophic Cardiomyopathy (2012)

This study reports novel and potentially pathogenic sequence variants in genes of the RAS-MAPK pathway, suggesting that genetic lesions promoting signaling dysregulation through RAS contribute to disease pathogenesis or progression in children with HCM.
A Synthetic Block Copolymer Regulates S1 Nuclease Fragmentation of Supercoiled Plasmid DNA (2005)

Aus eins mach sieben: Mit wasserlöslichen kationischen Blockcopolymeren komplexierte superhelicale Plasmid-DNA wurde durch S1-Nuclease hoch geordnet gespalten (siehe Bild). Die Ergebnisse verschaffen einen Einblick in die Mechanismen endogener Protein-induzierter DNA-Modifizierung und in das Design künstlicher Restriktionsenzyme durch supramolekulare Organisation synthetischer Makromoleküle. Supporting Information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2005/z500201_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Noise2Recon: Enabling SNR‐robust MRI reconstruction with semi‐supervised and self‐supervised learning (2023)

Noise2Recon is a label-efficient reconstruction method that is robust to distribution shifts, such as changes in SNR, acceleration factors, and others, with limited or no fully sampled training data.
Fixed-Time Second Order Sliding Mode Guidance Law for Interceptors with Impact Angle Constraints (2019)

This paper presents a fixed-time second order sliding mode guidance law for interceptors with impact angle constraints. Firstly, the zero placement principle of close-loop system is carried out, and it make it convenient to adjust the state motion trajectory and improve the dynamic performance. Then, a novel fixed-time convergent super-twisting guidance law is proposed based on this principle. The efficiency of proposed algorithm are demonstrated through simulations under separated scenarios, and it is shown the desired impact angle can be guaranteed within fixed convergence time.
Crystalline Copper(II) Phthalocyanine Catalysts for Electrochemical Reduction of Carbon Dioxide in Aqueous Media (2017)

We achieved highly selective electrochemical reduction of CO2 to C2H4 (faradaic efficiency of 25%) by crystalline copper phthalocyanine (CuPc) supported on carbon black. Remarkably, noncrystalline CuPc generated by treatment of crystalline CuPc with sulfuric acid did not give C2H4 selectively, suggesting that catalyst crystallinity is crucial for the selective conversion of CO2 to C2H4. The stability of crystalline CuPc under electrochemical reduction conditions was also evaluated, showing that crystalline CuPc can selectively convert CO to C2H4 in the initial stage (<10 000 s), as long as the crystallinity of the catalyst is maintained.
Time-frequency localization operators (2003)

A technique for producing signals whose energy is concentrated in a given region of the time-frequency plane is examined. The degree to which a given signal is concentrated in a region is measured by integrating its time-frequency distribution over the region. This method has been used for time-varying filtering. Localization operators based on the Wigner distribution and spectrogram are studied. Estimates for the eigenvalue decay and the smoothness and decay of the eigenfunctions are presented.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Continuous curvilinear capsulorhexis in intumescent or hypermature cataract with liquefied cortex (2003)

We describe a technique to prevent milky liquefied cortical matter from obscuring the view of the anterior chamber and radial tears caused by high intracapsular pressure in eyes with hypermature or intumescent cataract. The continuous curvilinear capsulorhexis (CCC) is created in a sealed anterior chamber without capsule staining or viscoelastic material. Ninety-four consecutive CCCs were performed by a single surgeon over 24 months using the method. A successful CCC was achieved in all eyes. Four cases had complications that occurred late in the surgery and were not related to the CCC.
Cover Picture (2002)

The cover picture shows the schematic coupling cycle utilized on the first automated solid-phase oligosaccharide synthesizer to rapidly prepare oligosaccharides from glycosyl phosphate building blocks. Details are discussed in the Microreview by P. H. Seeberger et al. on page 595 ff.
Guiding of High-Intensity Laser Pulses with a Hydrogen-Filled Capillary Discharge Waveguide (2002)

We report guiding of laser pulses with peak input intensities greater than 10(17) W cm(-2) in 30 mm and 50 mm long H2-filled capillary discharge waveguides. Under conditions producing good guiding the coupling and propagation losses of the waveguide were <4% and (7+/-1) m(-1), respectively. The spectra of the transmitted pulses were not broadened significantly, but were shifted to shorter wavelength. It is concluded that this shift is not associated with significant temporal distortion of the laser pulse.
Investigating Local Structure in Layered Double Hydroxides with <sup>17</sup>O NMR Spectroscopy (2013)

A new method based on the “memory effect” for efficient and economical 17 O labeling of layered double hydroxides (LDHs) is introduced. High‐quality 17 O solid‐state NMR spectra are obtained, for the first time, for LDHs prepared with only several hundred microliters of 17 O‐enriched H 2 O. The 17 O resonances due to the different oxygen ions in the structure of LDHs can be resolved with better resolution than the results obtained from 1 H ultrafast magic angle spinning (MAS) NMR spectroscopy. The results show clear evidence for Al–O–Al avoidance. Since only intermediate MAS speeds and fields are used, this new approach can be incorporated easily with a variety of dipolar recoupling schemes to explore the key interactions and applications of LDHs.
Combining freeform optics and curved detectors for wide field imaging: a polynomial approach over squared aperture (2017)

In the recent years a significant progress was achieved in the field of design and fabrication of optical systems based on freeform optical surfaces. They provide a possibility to build fast, wide-angle and high-resolution systems, which are very compact and free of obscuration. However, the field of freeform surfaces design techniques still remains underexplored. In the present paper we use the mathematical apparatus of orthogonal polynomials defined over a square aperture, which was developed before for the tasks of wavefront reconstruction, to describe shape of a mirror surface. Two cases, namely Legendre polynomials and generalization of the Zernike polynomials on a square, are considered. The potential advantages of these polynomials sets are demonstrated on example of a three-mirror unobscured telescope with F/# = 2.5 and FoV = 7.2x7.2°. In addition, we discuss possibility of use of curved detectors in such a design.
Modular Parallelization Framework for Multi-Stream Video Processing (2016)

A flow-based software framework specialized for 3D and video is presented, which in particular handles automatic parallelization of multi-stream video processing. The workflow is decomposed into a set of filter units which become nodes in a graph. Execution with support for time windows on node inputs is automatically handled by the framework, as well as low-level manipulation of multi-dimensional data.
Machine Learning and Data Science in Chemical Engineering (2022)

ADVERTISEMENT RETURN TO ISSUEEditorialNEXTMachine Learning and Data Science in Chemical EngineeringHanyu Gao*Hanyu GaoDepartment of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, People's Republic of China*E-mail: [email protected]More by Hanyu Gaohttps://orcid.org/0000-0002-6346-0739, Li-Tao ZhuLi-Tao ZhuDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of ChinaMore by Li-Tao Zhuhttps://orcid.org/0000-0001-6514-8864, Zheng-Hong LuoZheng-Hong LuoDepartment of Chemical Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, People's Republic of ChinaMore by Zheng-Hong Luohttps://orcid.org/0000-0001-9011-6020, Marco A. FragaMarco A. FragaInstituto Nacional de Tecnologia − INT, Av. Venezuela, 82/518, Rio de Janeiro, RJ 20081-312, BrazilMore by Marco A. Fragahttps://orcid.org/0000-0002-9768-8360, and I-Ming HsingI-Ming HsingDepartment of Chemical and Biological Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong SAR, People's Republic of ChinaMore by I-Ming HsingCite this: Ind. Eng. Chem. Res. 2022, 61, 24, 8357–8358Publication Date (Web):June 22, 2022Publication History Published online22 June 2022Published inissue 22 June 2022https://pubs.acs.org/doi/10.1021/acs.iecr.2c01788https://doi.org/10.1021/acs.iecr.2c01788editorialACS PublicationsCopyright © Published 2022 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views16091Altmetric-Citations4LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (523 KB) Get e-AlertscloseSUBJECTS:Bioengineering and biotechnology,Chemical engineering and industrial chemistry,Machine learning,Molecular modeling,Molecular structure Get e-Alerts
Liver Transplantation—An Overview (2008)

This chapter is intended to review the current state of liver trans­ plantation. Patient selection, current organ allocation and an outline of current strategies to improve donor shortages will be addressed. Pre and post-operative variables associated with patent and graft survival, as well as disease recurrence will be outlined. Finally, a summary of current immunosuppression strategies and their associated toxicities will be reviewed.
Mobile Terminal Antenna Performance With the User's Hand: Effect of Antenna Dimensioning and Location (2011)

This letter reports a systematic simulation study of the performance of mobile terminal antennas in the vicinity of the user's hand. The effects of antenna dimensioning and antenna location on the ground plane of the device are demonstrated. The studied performance parameters are quality factor, radiation efficiency, and frequency detuning. Based on the results, beneficial approaches and general guidelines for antenna designs with a reduced effect of the user's hand can be given. For instance, it is shown that the radiation efficiency with the user's hand stays nearly constant (variation <;0.2 dB) despite the changes in the antenna element height (2-6.6 mm at 900 and 2000 MHz).
Escape dynamics of a particle from a purely-nonlinear truncated quartic potential well under harmonic excitation (2021)

This paper focuses on the escape problem of a harmonically-forced classical particle from a purely-quartic truncated potential well. The latter corresponds to various engineering systems that involve purely cubic restoring force and absence of linear stiffness even under the assumption of small oscillations, such as pre-tensioned metal wires and springs, and compliant structural components made of polymer materials. This, in contrast to previous studies where the equivalent potential well could be treated as linear at first approximation under the assumption of small perturbations. Due to the strong nonlinearity of the current potential well, traditional analytical methods are inapplicable for describing the transient bounded and escape dynamics of the particle. The latter is analyzed in the framework of isolated resonance approximation by canonical transformation to action-angle (AA) variables and the corresponding reduced resonance manifold (RM). The escape envelope is formulated analytically. Surprisingly, despite the essential nonlinearity of the well, it exhibits a universal property of a sharp minimum due to the existence of multiple intersecting escape mechanisms. Unlike previous studies, three underlying mechanisms that govern the transient dynamics of the particle were identified: two maximum mechanisms and a saddle mechanism. The first two correspond to a gradual increase in the system's response amplitude for a proportional increase in the excitation intensity, and the latter corresponds to an abrupt increase in the system's response and therefore more potentially hazardous. The response of the particle is described in terms of energy-based response curves. The maximal transient energy is predicted analytically over the space of excitation parameters and described using iso-energy contours. All theoretical predictions are in complete agreement with numerical results.
CCR2-Dependent Recruitment of Tregs and Monocytes Following Radiotherapy Is Associated with TNFα-Mediated Resistance (2019)

Radiotherapy (RT) represents one of the main anticancer approaches for the treatment of solid tumors. Beyond the expected direct effects of RT on tumor cells, evidence supporting the importance of an immune response to RT is growing. The balance between RT-mediated immunogenic and tolerogenic activity is ill-defined and deserves more attention. Herein, a murine model of head and neck squamous cell carcinoma was used to demonstrate that RT upregulated CCL2 chemokine production in tumor cells, leading to a CCR2-dependent accumulation of tumor necrosis factor alpha (TNFα)-producing monocytes and CCR2<sup>+</sup> regulatory T cells (Treg). This corecruitment was associated with a TNFα-dependent activation of Tregs, dampening the efficacy of RT. Our results highlight an unexpected cross-talk between innate and adaptive immune system components and indicate CCL2/CCR2 and TNFα as potential clinical candidates to counterbalance the radioprotective action of monocyte-derived cells and Tregs, paving the way for potent combined radioimmunotherapies.
Micronutrient intakes of pre-adolescent children living in London (2009)

The aim of the current study was to report on the micronutrient intakes of a sample of pre-adolescent children from a range of socio-economic backgrounds. Eighty-five children aged 7-10 years completed 7-day weighed food diaries, which were used to assess habitual intake of selected micronutrients. Intakes were then compared with the current Department of Health reference values and the findings of the UK National Diet and Nutrition Survey for young people. These children failed to meet the reference values set by the Department of Health for zinc (73% of sample) and potassium (68% of sample), and intakes of calcium, potassium, vitamin B(12), vitamin D and folate were lower than the findings of the UK National Diet and Nutrition Survey. Among this sample, dietary changes are required to ensure that children follow a well-balanced diet for optimum health and development.
Electronegativity and molecular geometry. II. The concept of a free relaxing molecule and assessment of its geometry on the basis of the electrostatic approach (1987)

The concept of a free relaxing molecule (FRM) was introduced during the development of a method for the description of the stereochemical structure of molecules on the basis of electrostatic theories. Postulates and rules which make it possible to assess the bond lengths and bond angles in the FRM from the electronegativities of the atoms are proposed. The relationships formulated for the FRM were demonstrated for the case of specific organic molecules.
Unusual Weiss–Cook condensation of dimethyl 2,3-dioxobutanedioate and dimethyl 3-oxoglutarate (1994)

The Weiss–Cook condensation of dimethyl 2,3-dioxobutanedioate with two equivalents of dimethyl 3-oxoglutarate in aqueous bicarbonate produces an "abnormal" product, pentamethyl cis-3-(carbomethoxymethyl)-3,7-dihydroxy-2-oxabicyclo-[3.3.0]oct-7-ene-1,4,5,6,8-pentacarboxylate 7, whose structure has been determined by X-ray crystallography. Rrapcho decarbomethoxylation (sodium chloride, aqueous dimethyl sulfoxide, 140 °C) of this compound produces dimethyl cis-3,7-dioxobi-cyclo[3.3.0]octane-1,5-dicarboxylate 4 in quantitative yield. These results suggest that compound 7 may be the product of a kinetically controlled reaction pathway involving 4-hydroxypent-2-en-1-one intermediate 5. Heating of 7 in dimethyl sulfoxide may have promoted thermodynamic equilibration to a Weiss–Cook product, which then decarbomethoxylated to produce 4.
Land use structures fish assemblages in reservoirs of the Tennessee River (2015)

Inputs of nutrients, sediments and detritus from catchments can promote selected components of reservoir fish assemblages, while hindering others. However, investigations linking these catchment subsidies to fish assemblages have generally focussed on one or a handful of species. Considering this paucity of community-level awareness, we sought to explore the association between land use and fish assemblage composition in reservoirs. To this end, we compared fish assemblages in reservoirs of two sub-basins of the Tennessee River representing differing intensities of agricultural development, and hypothesised that fish assemblage structure indicated by species percentage composition would differ among reservoirs in the two sub-basins. Using multivariate statistical analysis, we documented inter-basin differences in land use, reservoir productivity and fish assemblages, but no differences in reservoir morphometry or water regime. Basins were separated along a gradient of forested and non-forested catchment land cover, which was directly related to total nitrogen, total phosphorous and chlorophyll-a concentrations. Considering the extensive body of knowledge linking land use to aquatic systems, it is reasonable to postulate a hierarchical model in which productivity has direct links to terrestrial inputs, and fish assemblages have direct links to both land use and productivity. We observed a shift from an invertivore-based fish assemblage in forested catchments to a detritivore-based fish assemblage in agricultural catchments that may be a widespread pattern among reservoirs and other aquatic ecosystems.