gebhart/patrepeval huggingface dataset:
Analog memristive and memcapacitive properties of Ti / AI&lt;inf&gt;2&lt;/inf&gt;O&lt;inf&gt;3&lt;/inf&gt; / Nb&lt;inf&gt;2&lt;/inf&gt;O&lt;inf&gt;5&lt;/inf&gt; / Ti resistive switches (2017)

Versatile resistance switching effects in niobium oxide based MIM structures have been reported. Besides the filamentary resistance and threshold switching effects, which occur after an initial electroforming process, a forming free resistance switching operation was found in a double layer structure of Nb <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">5</sub> and Al <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sub> . In our work we report on the co-existence of a capacitance change accompanying the analog resistance switching effect. This memcapacitive effect might enable new applications in analog circuits, which go beyond the pure data storage. Results of IV-and CV characterization as well as impedance spectroscopy are presented. Furthermore, a physical model is proposed which describes the underlying mechanisms as interfacial quantum mechanical effect based on charging and discharging of electron trap states.
&lt;title&gt;Force and membrane compliance measurements using laser interferometry and optical trapping&lt;/title&gt; (1993)

The development of the single beam gradient force optical trap has improved the experimental capabilities available to cell biologists for noninvasive micromanipulation and mechanical measurement on living cells. Laser traps can be used not only to optically manipulate particles including bacteria, yeast cells, and intracellular organelles ranging in size from 25 nm to 25 micrometers with fine control of position (10 nm) but also to measure small (0.1 pN) forces in biological systems. For a given particle, trapping forces are linearly related to the laser power so that a relatively simple way of measuring force is to trap a particle at high power and gradually reduce it until the particle just escapes from the trap. The `escape' power, which is usually calibrated against the viscous drag of the aqueous medium at varying laser power levels, is a measure of the force.
Sztuka i jej cień. Sztuka w ujęciu Emmanuela Levinasa w kontekście zwrotu estetycznego w fenomenologii francuskiej (2022)

Celem artykułu jest zadanie pytania o znaczenie sztuki w filozofii Emmanuela Levinasa, uwzględniające nie tylko znany tekst Rzeczywistość i jej cień, ale także teksty z późniejszego okresu jego twórczości. Pierwsza część artykułu to interpretacja Rzeczywistości i jej cienia w kontekście współczesnych koncepcji fenomenologicznych. Druga natomiast będzie próbą pokazania zmiany, jaka zaszła w podejściu Levinasa do sztuk wizualnych na podstawie jego wypowiedzi na temat malarstwa Jeana-Michela Atlana i rzeźb Sachy Sosno. Trzecia, podsumowująca część, będzie z kolei próbą opisania dzieł sztuki współczesnej, które wymknęłyby się być może surowej ocenie sztuki dokonanej przez Levinasa, uwypuklając napięcie między wymiarem ontologii a etyką, nie popadając w banalne moralizatorstwo i pozwalając na ujawnienie krzywdy, nieprowadzącej jednak widza do etycznego paraliżu.
Evaluation and Treatment of Congenital Facial Paralysis (1983)

An approach to the evaluation and the preferred methods of treatment of congenital facial paralysis is presented. The expected results from testing procedures and the limitations of their usefulness in acquired v developmental palsies are discussed. We recommend that the auditory brain-stem response test be included in the initial evaluation of patients with congenital facial paralysis.
Out-of-field doses from pediatric craniospinal irradiations using 3D-CRT, IMRT, helical tomotherapy and electron-based therapy (2017)

Medulloblastoma treatment involves irradiation of the entire central nervous system, i.e. craniospinal irradiation (CSI). This is associated with the significant exposure of large volumes of healthy tissue and there is growing concern regarding treatment-associated side effects. The current study compares out-of-field organ doses in children receiving CSI through 3D-conformal radiotherapy (3D-CRT), intensity modulated radiotherapy (IMRT), helical tomotherapy (HT) and an electron-based technique, and includes radiation doses resulting from imaging performed during treatment. An extensive phantom study is performed, using an anthropomorphic phantom corresponding to a five year old child, in which organ absorbed doses are measured using thermoluminescent detectors. Additionally, the study evaluates and explores tools for calculating out-of-field patient doses using the treatment planning system (TPS) and analytical models. In our study, 3D-CRT resulted in very high doses to a limited number of organs, while it was able to spare organs such as the lungs and breast when compared to IMRT and HT. Both IMRT and HT spread the dose over more organs and were able to spare the heart, thyroid, bladder, uterus and testes when compared to 3D-CRT. The electron-based technique considerably decreased the out-of-field doses in deep-seated organs but could not avoid nearby out-of-field organs such as the lungs, ribs, adrenals, kidneys and uterus. The daily imaging dose is small compared to the treatment dose burden. The TPS error for out-of-field doses was most pronounced for organs further away from the target; nevertheless, no systematic underestimation was observed for any of the studied TPS systems. Finally, analytical modeling was most optimal for 3D-CRT although the number of organs that could be modeled was limited. To conclude, none of the techniques studied was capable of sparing all organs from out-of-field doses. Nevertheless, the electron-based technique showed the most promise for out-of-field organ dose reduction during CSI when compared to photon techniques.
Cr<sub>2</sub>O<sub>3</sub>nanosheet/carbon cloth anode with strong interaction and fast charge transfer for pseudocapacitive energy storage in lithium-ion batteries (2019)

Flexible lithium-ion batteries have attracted considerable interest for next-generation bendable, implantable and wearable electronics devices. Here, we have successfully grown Cr<sub>2</sub>O<sub>3</sub> nanosheets on carbon cloth (CC) as freestanding anodes for Li-ion batteries (LIBs). Density functional theory (DFT) calculations verify an optimal structure of two-dimensional Cr<sub>2</sub>O<sub>3</sub> nanosheets on the carbon fiber surface and a strong interaction between the O edges of Cr<sub>2</sub>O<sub>3</sub> and the carbon. The interconnected Cr<sub>2</sub>O<sub>3</sub> nanosheets with a large surface area enable fast charge transfer by efficient contact with electrolyte while the flexible CC substrate accommodates the volume change during cycles, leading to excellent rate capability and cyclic stability through psuedocapacitance-dominant energy storage. Full cells are assembled using the Cr<sub>2</sub>O<sub>3</sub>-CC anode and a LiFePO<sub>4</sub> cathode, which deliver excellent capacity retention and rate capability. The fully-charged cell is demonstrated to power a red light-emitting diode (LED), verifying the potential of Cr<sub>2</sub>O<sub>3</sub>-CC as a promising anode material for LIBs.
Sespendole, a New Inhibitor of Lipid Droplet Synthesis in Macrophages, Produced by Pseudobotrytis terrestris FKA‐25 (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Boronate affinity-based photoactivatable magnetic nanoparticles for the oriented and irreversible conjugation of Fc-fused lectins and antibodies (2019)

The utilization of immuno-magnetic nanoparticles (MNPs) for the selective capture, enrichment, and separation of specific glycoproteins from complicated biological samples is appealing for the discovery of disease biomarkers. Herein, MNPs were designed and anchored with abundant boronic acid (BA) and photoreactive alkyl diazirine (Diaz) functional groups to obtain permanently tethered Fc-fused Siglec-2 and antiserum amyloid A (SAA) mAb with the assistance of reversible boronate affinity and UV light activation in an orientation-controlled manner. The Siglec-2-Fc-functionalized MNPs showed excellent stability in fetal bovine serum (FBS) and excellent efficiency in the extraction of cell membrane glycoproteins. The anti-SAA mAb-functionalized MNPs maintained active Ab orientation and preserved antigen recognition capability in biological samples. Thus, the BA-Diaz-based strategy holds promise for the immobilization of glycoproteins, such as antibodies, with the original protein binding activity maintained, which can provide better enrichment for the sensitive detection of target proteins.
Thermoelectric properties of aligned carbon nanotubes (2008)

We have investigated the thermoelectric (TE) properties of films composed of aligned and randomly dispersed n-type, p-type, and p-n junctions. The TE voltage that was developed across aligned films was larger than the voltage developed along their axis of symmetry by a factor of almost 3. The TE voltage that developed across aligned and parallel p-n junction was almost seven times larger then the voltage developed over randomly oriented p-type only films.
Responders Analysis in Patients With Diarrhea-Predominant Irritable Bowel Syndrome (IBS-D) Treated With Rifaximin (2017)

Introduction: Rifaximin is a nonsystemic antibiotic indicated for the treatment of IBS-D in adults. This post hoc analysis evaluated rifaximin efficacy using modified definitions of response and recurrence. Methods: As part of a phase 3 repeat treatment trial, adults with IBS-D were treated with open-label rifaximin 550 mg 3 times daily for 2 weeks. In the original analysis, patients with ≥30% decrease from baseline in mean weekly pain score and ≥50% decrease from baseline in number of days/week with BSS type 6 or 7 stool during ≥2 of the first 4 weeks post-treatment were considered responders. Responders were followed (observation phase) for an additional 18 weeks or until recurrence (<30% decrease from baseline in mean weekly pain score or<50% decrease from baseline in number of days/week with BSS type 6 or 7 stool for ≥3 weeks of a consecutive, rolling 4-week period). Nonresponders were withdrawn from the study. The current post hoc analysis employed a modified composite definition of responders: patients with a ≥30% improvement from baseline in abdominal pain score, recorded on ≥50% of the days during the first 4 weeks post-treatment, and a BSS score ≤5 on the same days. In patients who continued into the observation phase, abdominal pain recurrence (<30% improvement from baseline in abdominal pain on ≥50% of the days in a week) and abdominal pain and stool consistency recurrence (<30% improvement from baseline in abdominal pain and BSS score >5 on ≥50% of the days in a week) for a given week or ≥2 consecutive weeks were determined. Results: 2579 patients (mean age, 46.4 y; baseline mean ± standard deviation daily abdominal pain score, 5.5 ± 1.7 and stool consistency score, 5.6 ± 0.8) were treated. A total of 1071 (41.5%) patients were classified as responders using the post hoc definition; 982 of these patients were eligible for follow-up for an additional 18 weeks (observation phase). For abdominal pain, 38.3% of 982 patients did not experience recurrence during each week of the observation phase and 57.3% did not experience recurrence during ≥2 consecutive weeks. For abdominal pain and stool consistency (composite), 53.9% of patients did not experience recurrence during each week of the observation phase and 74.1% did not experience recurrence during ≥2 consecutive weeks. Conclusion: A 2-week course of rifaximin was efficacious in improving symptoms of abdominal pain and stool consistency in patients with IBS-D.
Memory-like NK cells armed with a neoepitope-specific CAR exhibit potent activity against NPM1 mutated acute myeloid leukemia (2022)

Acute myeloid leukemia (AML) remains a therapeutic challenge, and a paucity of tumor-specific targets has significantly hampered the development of effective immune-based therapies. Recent paradigm-changing studies have shown that natural killer (NK) cells exhibit innate memory upon brief activation with IL-12 and IL-18, leading to cytokine-induced memory-like (CIML) NK cell differentiation. CIML NK cells have enhanced antitumor activity and have shown promising results in early phase clinical trials in patients with relapsed/refractory AML. Here, we show that arming CIML NK cells with a neoepitope-specific chimeric antigen receptor (CAR) significantly enhances their antitumor responses to nucleophosphmin-1 (NPM1)-mutated AML while avoiding off-target toxicity. CIML NK cells differentiated from peripheral blood NK cells were efficiently transduced to express a TCR-like CAR that specifically recognizes a neoepitope derived from the cytosolic oncogenic NPM1-mutated protein presented by HLA-A2. These CAR CIML NK cells displayed enhanced activity against NPM1-mutated AML cell lines and patient-derived leukemic blast cells. CAR CIML NK cells persisted in vivo and significantly improved AML outcomes in xenograft models. Single-cell RNA sequencing and mass cytometry analyses identified up-regulation of cell proliferation, protein folding, immune responses, and major metabolic pathways in CAR-transduced CIML NK cells, resulting in tumor-specific, CAR-dependent activation and function in response to AML target cells. Thus, efficient arming of CIML NK cells with an NPM1-mutation-specific TCR-like CAR substantially improves their innate antitumor responses against an otherwise intracellular mutant protein. These preclinical findings justify evaluating this approach in clinical trials in HLA-A2<sup>+</sup> AML patients with NPM1c mutations.
Floating Body Effects on the RF Performance of FDSOI RF Amplifiers (2006)

The impact of body contacts on the floating body effect of fully depleted (FD) SOI at high frequencies is studied. It is found that the floating body effect is negligibly small for FDSOI FETs and the body contact (BC) increased parasitic capacitance and degraded the performance. We show that the linearity of an X-band amplifier, fabricated with a 180-nm FDSOI technology, is unchanged by the BC in continuous wave and pulse mode operations.
Choline acetyltransferase–expressing T cells are required to control chronic viral infection (2019)

Although widely studied as a neurotransmitter, T cell-derived acetylcholine (ACh) has recently been reported to play an important role in regulating immunity. However, the role of lymphocyte-derived ACh in viral infection is unknown. Here, we show that the enzyme choline acetyltransferase (ChAT), which catalyzes the rate-limiting step of ACh production, is robustly induced in both CD4<sup>+</sup> and CD8<sup>+</sup> T cells during lymphocytic choriomeningitis virus (LCMV) infection in an IL-21-dependent manner. Deletion of <i>Chat</i> within the T cell compartment in mice ablated vasodilation in response to infection, impaired the migration of antiviral T cells into infected tissues, and ultimately compromised the control of chronic LCMV clone 13 infection. Our results reveal a genetic proof of function for ChAT in T cells during viral infection and identify a pathway of T cell migration that sustains antiviral immunity.
Integration of enzyme, strain and reaction engineering to overcome limitations of baker's yeast in the asymmetric reduction of α‐keto esters (2008)

We report on the development of a whole-cell biocatalytic system based on the popular host Saccharomyces cerevisiae that shows programmable performance and good atom economy in the reduction of alpha-keto ester substrates. The NADPH-dependent yeast reductase background was suppressed through the combined effects of overexpression of a biosynthetic NADH-active reductase (xylose reductase from Candida tenuis) to the highest possible level and the use of anaerobic reaction conditions in the presence of an ethanol co-substrate where mainly NADH is recycled. The presented multi-level engineering approach leads to significant improvements in product optical purity along with increases in the efficiency of alpha-keto ester reduction and co-substrate yield (molar ratio of formed alpha-hydroxy ester to consumed ethanol). The corresponding alpha-hydroxy esters were obtained in useful yields (>50%) with purities of > or =99.4% enantiomeric excess. The obtained co-substrate yield reached values of greater than 1.0 with acetate as the only by-product formed.
Interaction of Bacteriophage T7 Gene 4 Primase with Its Template Recognition Site (1999)

The primase fragment of the bacteriophage T7 63-kDa gene 4 helicase/primase protein contains the 271 N-terminal amino acid residues and lacks helicase activity. The primase fragment catalyzes the synthesis of oligoribonucleotides at rates similar to those catalyzed by the full-length protein in the presence of a 5-nucleotide DNA template containing a primase recognition site (5'-GGGTC-3', 5'-TGGTC-3', 5'-GTGTC-3', or 5'-TTGTC-3'). Although it is not copied into the oligoribonucleotides, the cytosine at the 3'-position is essential for synthesis and template binding. Two nucleotides flanking the 3'-end of the recognition site are required for tight DNA binding and rapid oligoribonucleotide synthesis. Nucleotides added to the 5'-end have no effect on the rate of oligoribonucleotide synthesis or the affinity of the primase for DNA. The binding of either ATP or CTP significantly increases the affinity of the primase for its DNA template. DNA lacking a primase recognition site does not inhibit oligoribonucleotide synthesis, suggesting that the primase binds DNA in a sequence-specific manner. The affinity of the primase for templates is weak, ranging from 10 to 150 microM. The tight DNA binding (<1 microM) observed with the 63-kDa gene 4 protein occurs via interactions between DNA templates and the helicase domain.
Selective nitration of aromatic compounds by solid acid catalysts (2000)

High activity and para-selectivity in the nitration of aromatic compounds is achieved by a high density of acidic sites and ready formation of the para-isomer in the pores of zeolite beta with low Si/Al ratio as revealed by molecular modeling studies.
Improving 3D geometry transformations on a simultaneous multithreaded SIMD processor (2001)

In this paper we evaluate the performance of an SMT processor used as the geometry processor for a 3D polygonal rendering engine. To evaluate this approach, we consider PMesa (a parallel version of Mesa) which parallelizes the geometry stage of the 3D pipeline. We show that SMT is suitable for 3D geometry and we characterize the execution of the geometry stage in term of memory hierarchy, which is the main bottleneck. The results show that latency is not fully recovered by SMT; the use of L2 data prefetching does not succeed in increasing the performance. We show that this problem comes from a pollution of the instruction window by the threads experiencing L2 cache misses, thus reducing the window available for the other threads. We thus propose dcPRED, a hardware mechanism to predict L2 misses and control this pollution. Coupled with L2 data prefetching, dcPRED achieves gains up to 21% over the baseline SMT.
Characteristics of TaSixNy thin films as gate electrodes for dual gate Si-complementary metal-oxide-semiconductor devices (2004)

Reactively sputtered TaSixNy films have been investigated as gate electrodes for dual gate Si-complementary metal-oxide-semiconductor devices. The as-deposited TaSixNy films were amorphous over a wide range of compositions. After annealing at 1000 °C, Ta30Si33N37 film became crystalline, however Ta26Si28N52 film remained amorphous. The x-ray photoelectron spectroscopy shows a significant increase of Si–N bonding in the TaSixNy films with increasing N content. The presence of Si–N bonds is attributed to cause the amorphous nature of the high N containing TaSixNy films. The work functions of TaSixNy films were extracted by capacitance–voltage analysis. The work function values for TaSixNy films with varying N contents range from 4.26 to 4.35 eV after forming gas annealing at 400 °C for 30 min, suggesting that TaSixNy films have work functions appropriate for n-type metal-oxide-semiconductor devices. However, it was observed, after 1000 °C anneals, that the work function of TaSixNy films increased to ∼4.8 eV. We believe that the mechanism that causes the work function to increase is the formation of a Ta-disilicide layer at the interface of the electrode and the dielectric. Current–voltage characteristics of the TaSixNy gates showed lower gate leakage compared to the TaSix gates, due to the retarding formation of an interface layer in the TaSixNy/SiO2/p-Si structures.
Microscale diffusiophoresis of proteins (2020)

Abstract Living systems are characterised by their spatially highly inhomogeneous nature which is susceptible to modify fundamentally the behaviour of biomolecular species, including the proteins that underpin biological functionality in cells. Spatial gradients in chemical potential are known to lead to strong transport effects for colloidal particles, but their effect on molecular scale species such as proteins has remained largely unexplored. Here we demonstrate with microfluidic measurements that individual proteins can undergo strong diffusiophoretic motion in salt gradients in a manner which is sufficient to overcome diffusion and lead to dramatic changes in their spatial organisation on the scale of a cell. Moreover, we demonstrate that this phenomenon can be used to control the motion of proteins in microfluidics devices. These results open up a path towards a physical understanding of the role of gradients in living systems in the spatial organisation of macromolecules and highlight novel routes towards protein sorting applications on device.
Human RNase P ribonucleoprotein is required for formation of initiation complexes of RNA polymerase III (2015)

Human RNase P is implicated in transcription of small non-coding RNA genes by RNA polymerase III (Pol III), but the precise role of this ribonucleoprotein therein remains unknown. We here show that targeted destruction of HeLa nuclear RNase P inhibits transcription of 5S rRNA genes in whole cell extracts, if this precedes the stage of initiation complex formation. Biochemical purification analyses further reveal that this ribonucleoprotein is recruited to 5S rRNA genes as a part of proficient initiation complexes and the activity persists at reinitiation. Knockdown of RNase P abolishes the assembly of initiation complexes by preventing the formation of the initiation sub-complex of Pol III. Our results demonstrate that the structural intactness, but not the endoribonucleolytic activity per se, of RNase P is critical for the function of Pol III in cells and in extracts.
Finite-key security analysis for quantum key distribution with leaky sources (2018)

Security proofs of quantum key distribution (QKD) typically assume that the devices of the legitimate users are perfectly shielded from the eavesdropper. This assumption is, however, very hard to meet in practice, and thus the security of current QKD implementations is not guaranteed. Here, we fill this gap by providing a finite-key security analysis for QKD which is valid against arbitrary information leakage from the state preparation process of the legitimate users. For this, we extend the techniques introduced by Tamaki "et al" (2016 "New J. Phys." 18 065008) to the finite-key regime, and we evaluate the security of a leaky decoy-state BB84 protocol with biased basis choice, which is one of the most implemented QKD schemes today. Our simulation results demonstrate the practicability of QKD over long distances and within a reasonable time frame given that the legitimate users' devices are sufficiently isolated.