gebhart/patrepeval huggingface dataset:
Effects of walking on bilateral differences in spatial attention control: a cross-over design (2015)

Walking requires a high attentional cost for balance control and interferes with the control of attention. However, it is unclear whether the performance of visual spatial attention control, which is one of the functions of attention control, is also decreased during walking. In addition, although previous studies have shown right-hemispheric dominance and lower ability of left side visual spatial attention control during sitting, it remains unknown whether walking accentuates bilateral differences in visual spatial attention control. We tested the hypothesis that walking interferes with visual spatial attention control on both sides and accentuates its bilateral differences. Twenty healthy right-handed subjects (24.3 ± 2.0 years) participated in this study. Subjects performed a random stimulus–response compatibility (SRC) task during both sitting and walking situations. To evaluate the effects of walking, reaction time was measured on both sides for the two situations. In comparison to the both situations (sitting and walking), the amount of change of the SRC effect on both sides was used. In the comparing the bilateral difference (left and right), the difference of the SRC effect was evaluated in each situation. The paired t-test was applied to both comparisons for statistical analysis. The SRC effect on both sides during walking was significantly larger than during sitting (P < 0.05). In addition, walking significantly accentuated the bilateral differences in visual spatial attention control (P < 0.05). These results suggest that walking affects the performance of visual spatial attention control on both sides and accentuates its bilateral differences. These results have implications for development of practice methods of gait disorder with higher brain dysfunction.
Active vibration damping for manufacturing machines using additional cable mechanisms: conceptual design (2022)

Abstract Undesired vibration is a common issue when dealing with manufacturing machines, especially when dealing with thin structures. To decrease the external disturbance sensitivity of such systems, represented for example by machine tool quill, the auxiliary cable structure is attached to the system. The auxiliary cable structure increases system damping and decreases undesired structure vibrations by the passive or active way, depending on the deployment and purpose. In this article, cables are attached to the end-effector to suppress undesired vibrations and related experimental stand is prepared. Experimental stand parameters are identified using least square method. The control strategy using pole placement is presented and its suitability is verified using external disturbance force. The frequency analysis shows the promising behaviour of controlled cable structure attached to the original system as well as the experimental results.
Improving the Stability of a CaO-Based Sorbent for CO<sub>2</sub> by Thermal Pretreatment (2011)

Although the reversible absorption of CO2 by CaO at high temperature has been proposed as a promising method for capturing and removing CO2 from hot gas streams produced by the combustion of fossil fuels and other industrial processes, the activity of the sorbent has invariably declined when applied over many cycles of CO2 absorption and desorption. The objective of the present investigation was to extend the life cycle performance of the absorbent through improved thermal pretreatment as the absorbent was prepared from limestone, dolomite, calcium acetate, or plaster of Paris. The first three materials were converted to CaO by calcination, while the third being an impure form of CaSO4 required a combination of reduction and oxidation. The life cycle performance of an absorbent derived by calcination was found to depend on the calcination conditions including particle size, temperature, atmosphere, and length of treatment. Sorbent stability was favored by calcining fine-size particles (10 μm) at high temperature (1000 °C) in an atmosphere containing 50% CO2 or more. The sorbent derived from plaster of Paris by a cyclic process of reduction and oxidation at 1070 °C proved to be a very unusual material when applied because its activity increased rapidly and was still increasing after 200 cycles of absorption and regeneration.
Fast‐forward genetics by radiation hybrids to saturate the locus regulating nuclear–cytoplasmic compatibility in <i>Triticum</i> (2016)

The nuclear-encoded species cytoplasm specific (scs) genes control nuclear-cytoplasmic compatibility in wheat (genus Triticum). Alloplasmic cells, which have nucleus and cytoplasm derived from different species, produce vigorous and vital organisms only when the correct version of scs is present in their nucleus. In this study, bulks of in vivo radiation hybrids segregating for the scs phenotype have been genotyped by sequencing with over 1.9 million markers. The high marker saturation obtained for a critical region of chromosome 1D allowed identification of 3318 reads that mapped in close proximity of the scs. A novel in silico approach was deployed to extend these short reads to sequences of up to 70 Kb in length and identify candidate open reading frames (ORFs). Markers were developed to anchor the short contigs containing ORFs to a radiation hybrid map of 650 individuals with resolution of 288 Kb. The region containing the scs locus was narrowed to a single Bacterial Artificial Chromosome (BAC) contig of Aegilops tauschii. Its sequencing and assembly by nano-mapping allowed rapid identification of a rhomboid gene as the only ORF existing within the refined scs locus. Resequencing of this gene from multiple germplasm sources identified a single nucleotide mutation, which gives rise to a functional amino acid change. Gene expression characterization revealed that an active copy of this rhomboid exists on all homoeologous chromosomes of wheat, and depending on the specific cytoplasm each copy is preferentially expressed. Therefore, a new methodology was applied to unique genetic stocks to rapidly identify a strong candidate gene for the control of nuclear-cytoplasmic compatibility in wheat.
P4‐041: INTERNATIONAL ROUND ROBIN ON SRM TRIPLE QUAD MASS SPECTROMETRIC ANALYSIS OF Aβ42 IN CEREBROSPINAL FLUID (2014)

Measurement of the 42 amino acid form of amyloid β (Aβ42) in cerebrospinal fluid (CSF) is a well-established biomarker for Alzheimer's disease (AD) and is routinely measured using different immunoassays. However, broad-scale use of these antibody based techniques in clinical routine is hampered by high variability. Thus, there is a need for harmonization of CSF AD biomarker assays with high analytical precision, selectivity, stability and with low variability across centers. Mass spectrometry (MS) has been used for quantification of small molecules in the clinic for many years. A key difference of MS quantification compared to immunoassays is the ability to use stable isotope-labeled internal standards (IS). Thereby, MS has the potential to provide unbiased quantification unaffected by matrix effects, thus decreasing inter-laboratory variation. In the current study we test this hypothesis for CSF Aβ42 measurement in a round robin study involving 4 laboratories involved in the Global Consortium for Biomarker Standardization (GCBS) of the Alzheimer's Association. Aliquots from twelve pools of human CSF were distributed to the participating laboratories. Samples were spiked with 15N uniformly labeled Aβ42 (15N-Aβ42) as an IS and external calibration was performed either in human or artificial CSF. Spiked samples were denatured with guanidine hydrochloride, extracted using solid phase extraction (SPE) and injected on a reversed phase column prior to MS analysis in the selected reaction monitoring mode. The inter-laboratory variation showed excellent correlation (R2 > 0.98). The average intra-laboratory CVs was 4.7% while the average inter-laboratory CV was 12.2%. Since no reference material exists for CSF Aβ42, we evaluated the potential benefit of such a material by designating one of the samples as reference. Following this correction, the average inter-laboratory CV was 8.3%. Using SPE under denaturing conditions in combination with stable isotope-labeled IS overcomes the immune-affinity based center-to-center variations possibly due to elimination of matrix-effects and lot-to-lot variations between kits. Our study shows that MS Aβ42 assays established in four laboratories using different instrumentation, calibration methods, and different calibrant preparations, produce similar results. The use of a common reference sample further decreases inter-laboratory variation, highlighting the importance of developing a standard reference material.
Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial (2022)

Protective ventilation strategies are commonly applied in patients after cardiac arrest. Ventilator settings in the first 72 h after hospital admission, in particular driving pressure and respiratory rate, may influence 6-month outcomes.
Comparison of the long-term efficacy between entecavir and tenofovir in treatment- naïve chronic hepatitis B patients (2017)

Although either ETV or TDF, overall, may show a comparable long-term antiviral efficacy in treatment-naïve CHB, TDF might be better regimen than ETV in the subgroup of HBeAg-positive CHB, especially with a higher HBV DNA levels.
Human brain imaging post-mortem - whole hemisphere technologies (2001)

The use of whole post-mortem human brain hemispheres for the studies of the biochemical neuroanatomy is described. Cryosections prepared from whole hemispheres have been successfully used for in vitro radioligand autoradiography, in situ hybridization histochemistry and histochemistry. Functional autoradiography using 5-HT 1A receptor stimulated [ 35 S]GTP &#110 S binding and volume rendering of images from radioligand autoradiography to describe the distribution of D 2 /D 3 dopamine receptors in three dimensions are also discussed. A detailed characterization of the biochemical neuroanatomy of several neuronal components can thus be obtained simultaneously in all regions in the normal and diseased brain, resulting in an extensive information on the human brain morphology and biochemistry.
p53 Target Gene SMAR1 Is Dysregulated in Breast Cancer: Its Role in Cancer Cell Migration and Invasion (2007)

Tumor suppressor SMAR1 interacts and stabilizes p53 through phosphorylation at its serine-15 residue. We show that SMAR1 transcription is regulated by p53 through its response element present in the SMAR1 promoter. Upon Doxorubicin induced DNA damage, acetylated p53 is recruited on SMAR1 promoter that allows activation of its transcription. Once SMAR1 is induced, cell cycle arrest is observed that is correlated to increased phospho-ser-15-p53 and decreased p53 acetylation. Further we demonstrate that SMAR1 expression is drastically reduced during advancement of human breast cancer. This was correlated with defective p53 expression in breast cancer where acetylated p53 is sequestered into the heterochromatin region and become inaccessible to activate SMAR1 promoter. In a recent report we have shown that SMAR1 represses Cyclin D1 transcription through recruitment of HDAC1 dependent repressor complex at the MAR site of Cyclin D1 promoter. Here we show that downmodulation of SMAR1 in high grade breast carcinoma is correlated with upregulated Cyclin D1 expression. We also established that SMAR1 inhibits tumor cell migration and metastases through inhibition of TGFbeta signaling and its downstream target genes including cutl1 and various focal adhesion molecules. Thus, we report that SMAR1 plays a central role in coordinating p53 and TGFbeta pathways in human breast cancer.
Power Line Communications and the Smart Grid (2010)

The design of the Smart Grid requires solving a complex problem of combined sensing, communications and control and, thus, the problem of choosing a networking technology cannot be addressed without also taking into consideration requirements related to sensor networking and distributed control. These requirements are today still somewhat undefined so that it is not possible yet to give quantitative guidelines on how to choose one communication technology over the other. In this paper, we make a first qualitative attempt to better understand the role that Power Line Communications (PLCs) can have in the Smart Grid. Furthermore, we here report recent results on the electrical and topological properties of the power distribution network. The topological characterization of the power grid is not only important because it allows us to model the grid as an information source, but also because the grid becomes the actual physical information delivery infrastructure when PLCs are used.
Continuous flow thermolysis of azidoacrylates for the synthesis of heterocycles and pharmaceutical intermediates (2010)

An efficient, safe and scalable procedure for the continuous flow thermolysis of azidoacrylates to yield indoles has been developed and was applied to the synthesis of related heterocycles. The scalability of the process was demonstrated in the continuous flow synthesis of a precursor to the DAAO inhibitor 4H-furo[3,2-b]pyrrole-5-carboxylic acid.
Calculation of hydroxymethylation of a zeolite model (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCalculation of hydroxymethylation of a zeolite modelL. R. Sierra, E. Kassab, and E. M. EvlethCite this: J. Phys. Chem. 1993, 97, 3, 641–646Publication Date (Print):January 1, 1993Publication History Published online1 May 2002Published inissue 1 January 1993https://pubs.acs.org/doi/10.1021/j100105a018https://doi.org/10.1021/j100105a018research-articleACS PublicationsRequest reuse permissionsArticle Views63Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Inhibition of the Histone Lysine Methyltransferase EZH2 for the Treatment of Cancer (2015)

In recent years, there has been an increased effort in the development of therapies which target an epigenetic mode of action. Among thes e efforts include progress in the development of inhibitors of EZH2 (Enhancer of Zeste Homolog 2), a key epigenetic target with strong disease implications to cancer. Over the last 3+ years, multiple reports describing small molecule inhibitors of EZH2 have been described, including those for chemical probes and drug candidates which have entered the clinic as first-in-class agents. Recent progress in this emerging area is presented in this review.
Contamination-free solutions of selenium in amines for nanoparticle synthesis (2014)

We present, for the first time, versatile solutions of concentrated selenium, within an array of amines, in a fast and low temperature manner without contaminants. These solutions allow the unprecedented opportunity to synthesize a variety of pure selenium and selenide nanoparticles as well as mixed chalcogen sulfoselenide compounds.
Deep learning and radiomics framework for PSMA-RADS classification of prostate cancer on PSMA PET (2022)

The framework provided lesion-level and patient-level PSMA-RADS and PCa classification on PSMA PET images. The framework was interpretable and provided confidence and probability scores that may assist physicians in making more informed clinical decisions.
Structural and Sensory Characterization of Compounds Contributing to the Bitter Off-Taste of Carrots (<i>Daucus carota </i>L.) and Carrot Puree (2003)

Sequential application of solvent extraction, gel permeation chromatography, and HPLC in combination with taste dilution analyses revealed that not a sole compound but a multiplicity of bitter tastants contribute to the bitter off-taste of cold-stored carrots and commercial carrot puree, respectively. Among these bitter compounds, 3-methyl-6-methoxy-8-hydroxy-3,4-dihydroisocoumarin (6-methoxymellein), 5-hydroxy-7-methoxy-2-methylchromone (eugenin), 2,4,5-trimethoxybenzaldehyde (gazarin), (Z)-heptadeca-1,9-diene-4,6-diin-3,8-diol (falcarindiol), (Z)-heptadeca-1,9-diene-4,6-diin-3-ol (falcarinol), and (Z)-3-acetoxy-heptadeca-1,9-diene-4,6-diin-8-ol (falcarindiol 3-acetate) could be identified on the basis of MS as well as 1D- and 2D-NMR experiments. Due to the low concentrations of <0.1 mg/kg and the high taste thresholds found for eugenin and gazarin, these compounds could be unequivocally excluded as important contributors to the bitter taste of carrots. Calculation of bitter activity values as the ratio of their concentration to their bitter detection threshold clearly demonstrated that neither in fresh and stored carrots nor in commercial carrot puree did 6-methoxymellein contribute to the bitter off-taste. In contrast, the concentrations of falcarindiol in stored carrots and, even more pronounced, in carrot puree were found to be 9- and 13-fold above its low bitter detection concentration of 0.04 mmol/kg, thus demonstrating that this acetylenic diol significantly contributes to the bitter taste of the carrot products investigated.
Étude par RMN MAS liquide de<sup>31</sup>P de l'évolution des solutions d'acide 12-tungstophosphorique (ion de Keggin) en fonction du pH, de la dilution et du temps (2004)

\nHeteropoly acids of the Keggin type H$_{\\rm 8-x}$XM$_{12}$O$_{40}$, where X is the central atom (Si, P,...), x its\noxidation state and M, a transition metal (Mo, W,...) are well known as oxidation and acid catalysts. The\nchief disadvantage of heteropoly acids is their weak thermal stability, resulting in a degradation of the active\nphase. Therefore, several attempts were taken on to stabilize them by supporting on various carriers. Silica is\nan excellent support for the heteropoly acids. Generally, the solid is prepared by impregnation of the active\nphase by a solution. In this paper, we proposed to determine and quantify the different tungstophosphate\nspecies by choosing the optimal conditions to incorporate one of such species. Results obtained by $^{31}$P NMR\nin aqueous medium of tungstophosphate species were discussed by varying the pH, the dilution and the evolution duration.\n
Germline-Encoded T-cell Receptor Sequences are a Determinant of Diabetes Susceptibility and Islet-Antigen Recognition in the LEW.1WR1 Rat Model of Type-1 Diabetes (2013)

Our previous studies identified a T-cell receptor variable region, TCRV1313, as the genetic element underlying Iddm14, a strong quantitative trait locus (QTL) for rat autoimmune diabetes. Depletion of V[beta]13+ T-cells with an allele-specific monoclonal antibody (17D5) prevents diabetes in multiple rat models. To better understand the role of V1313 in diabetes, we examined islet T-cell transcripts in susceptible (LEW.1WR1) and resistant (LEW.1W and WF) strains treated with polyinosinic:polycytidylic acid (poly I:C) to induce disease. As T-cells clonally expand in response to antigen significant narrowing of TCR diversity, termed antigen focusing, occurs. V[beta]13+ T-cells showed substantial antigen focusing in LEW.1WR1 islets five days post induction characterized by a substantial decrease in CDR3 diversity. No transcripts of any TCR-VP isotype are antigen focused in LEW.1WR1 islets 4 days post induction indicating that V[beta]13+ T-cells contribute to the earliest antigen-specific event in diabetes development. V[beta]13 antigen focusing occurs prior to significant islet T-cell accumulation (day 7) or frank diabetes (day 10-14). V[beta]13+ transcripts increase in LEW.1WR1 islets during diabetes progression, whereas no T-cell transcripts of any TCR isotype accumulate in the islets of resistant rats during the same time. T-cell infiltration of LEW.1WR1 islets (Day7) is concurrent with insulin transcript upregulation suggesting [beta] cell damage and compensatory up-regulation of de-novo insulin synthesis. We also analyzed transcript clonality of rat TCR-Va5, ortholog of the dominant TCR-Va chain found on insulin B:9-23- reactive T-cells in NOD islets. TCR-Va5+ transcripts accumulate and clonal expand in pre-diabetic LEW.1WR1 islets, suggesting that rat Va5 also contributes to recognition islet autoantigen, presumably insulin B:9-23. Together these data provide additional evidence that genome-encoded TCR sequences are important determinants of genetic susceptibility to T1 D. Lastly, Iddm37, another important diabetes QTL, conditions rat diabetes susceptibility to poly I:C or KRV infection. Diubiquitin ( UBD) is a strong candidate gene in this interval. An orthologous susceptibility locus was identified in people bearing high-risk HLA-DR3/4 haplotypes. We sequenced human UBD from case and control subjects and identified a UBD promoter SNP that was significantly associated with latency to islet autoantibody development. This suggests that UBD may be important for diabetes susceptibility to environmental triggers in man.
Electroluminescence and thermal imaging of large-area Cu(In, Ga)Se&lt;inf&gt;2&lt;/inf&gt; modules (2013)

Spatially resolved electroluminescence (EL) and thermal imaging are utilized to identify scribing failures and device defects in large-area Cu(In, Ga)Se <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> modules. EL emission from modules under forward bias was captured by a NIR CCD camera. Thermal images under the same forward bias conditions were taken by a far IR camera. By combining measurements of EL imaging, thermal imaging, and hand-held microscopy, various EL imaging patterns have been explored and different scribing failure modes in the modules have been identified. This work demonstrates a methodology for evaluating some module performance loss mechanisms and allows quick feedback for production optimization.
Corrigendum: (<i>N</i>‐Phosphinoamidinate)cobalt‐Catalyzed Hydroboration: Alkene Isomerization Affords Terminal Selectivity (2016)

In Figure 1, <5% conversion of 2c to 3 when using 1-Fe was presented in the originally published manuscript. We have observed in subsequent repeat experiments that under these conditions 2c is transformed into a mixture of 3 (≈80%) and internal hydroboration products (≈20%). Though the source of poor catalytic performance originally observed for 1-Fe is unclear at present, it is possible that catalyst poisoning by an impurity in a commercial substrate may play a role. The authors apologize for any confusion caused as a result.1 Figure 2 Octene isomerization/hydroboration reactions catalyzed by 1-Fe and 1-Co and employing HBPin (conversions given on the basis of NMR spectroscopic data).