gebhart/patrepeval huggingface dataset:
Assessing Expedition Medical Needs (2008)

Having to evacuate a trip member for any reason, be it physical or psychological, disrupts, even can cancel, an expedition and places other trip members and rescuers at possible personal risk. The pretrip history and physical evaluation is the first defense in preventing the subsequent evacuation. Maintaining vigilance as to the trip members' medical and mental status during the trip is the second step toward prevention of this expensive and risky event.
Supramolecular Hydrogels from In Situ Host–Guest Inclusion between Chemically Modified Cellulose Nanocrystals and Cyclodextrin (2013)

When grafted β-cyclodextrin is used as targeting sites, Pluronic polymers have been introduced on the surface of cellulose nanocrystals by means of inclusion interaction between β-cyclodextrin and hydrophobic segment of the polymer. Because of the steric stabilization effect, surface poly(ethylene glycol) chains facilitate the dispersion and compatibility of nanocrystals, which also enhance the loading levels of nanocrystals in the hydrogel system. Meanwhile, uncovered poly(ethylene glycol) segments render the participating inclusion of α-cyclodextrin for the architecture of in situ hydrogels. Surface grafting and inclusion reactions were proved by solid (13)C NMR and FTIR. Grafting efficiency of β-cyclodextrin and inclusion efficiency of Pluronic on the surface of nanocrystals were confirmed by UV spectroscopy and elemental analysis. A significant enhancement of the structural and thermal stability of in situ hydrogels with high loading levels of modified nanocrystals (>5.77 wt %) was observed by rheological analysis. Further study reveals the performance and behavior of hydrogels under a different pH environment. Finally, in situ hydrogels were used as drug carrier for in vitro release of doxorubicin and exhibit the behavior of prolonged drug release with special release kinetics.
Topology and spin dynamics in magnetic molecules (2005)

We investigate the role of topology and distortions in the quantum dynamics of magnetic molecules, using a cyclic spin system as reference. We consider three variants of an antiferromagnetic molecular ring, i.e., ${\mathrm{Cr}}_{8}$, ${\mathrm{Cr}}_{7}\mathrm{Zn}$, and ${\mathrm{Cr}}_{7}\mathrm{Ni}$, characterized by low-lying states with different total spin $S$. We theoretically and experimentally study the low-temperature behavior of the magnetic torque as a function of the applied magnetic field. Near level crossings, this observable selectively probes quantum fluctuations of the total spin (``$S$ mixing'') induced by lowering of the ideal ring symmetry. We show that while a typical distortion of a model molecular structure is very ineffective in opening new $S$ mixing channels, the spin topology is a major ingredient to control the degree of $S$ mixing. This conclusion is further substantiated by low-temperature heat capacity measurements.
Fast Reaction of Solid Copper(I) Complexes with Hydrogen Sulfide Gas (2001)

The low-temperature reactions of H2S (0.2−500 ppm) with Cu2O and a group of copper(I) complexes have been studied. [Cu(OAc)]n, Cu4(OCOCF3)4(C6H6)2, and Cu(hfac)L where hfac = hexafluoropentanedionate and L = 1,5-cyclooctadiene (COD) or diphenylacetylene reacted rapidly and quantitatively. Cu2(hfac)2LL where LL = cyclooctatetraene or norbornadiene and [Cu(OCOC6H5]4 reacted slowly or not at all. Rapid and quantitative conversion is apparently enabled by the displacement of ligands of large molar volume resulting in a porous Cu2S product. Cu(hfac)(COD) is nonporous, and quantitative studies were carried out in a packed-bed reactor for three size ranges of particles. The initial rate is first order in H2S and, according to an approximate estimate, appears to be dependent on the external surface area of the particles. The rates of reaction were faster than those of commonly used absorbents, while the stoichiometric conversion is unusual. Such properties suggest applications in gas cleanup and chemical analysis of H2S.
A robust identification algorithm for traffic models in telecommunications (2003)

The goal of this paper is to present a robust identification algorithm for the parameters of autoregressive stochastic processes, and employ this in analyzing telecommunication traffic data, mainly video traffic in ATM networks.
NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy (2020)

The pathological hallmark of synucleinopathies, including Lewy body dementia and Parkinson's disease (PD), is the presence of Lewy bodies, which are primarily composed of intracellular inclusions of misfolded α-synuclein (α-syn) among other proteins. α-Syn is found in extracellular biological fluids in PD patients and has been implicated in modulating immune responses in the central nervous system (CNS) and the periphery. Natural killer (NK) cells are innate effector lymphocytes that are present in the CNS in homeostatic and pathological conditions. NK cell numbers are increased in the blood of PD patients and their activity is associated with disease severity; however, the role of NK cells in the context of α-synucleinopathies has never been explored. Here, we show that human NK cells can efficiently internalize and degrade α-syn aggregates via the endosomal/lysosomal pathway. We demonstrate that α-syn aggregates attenuate NK cell cytotoxicity in a dose-dependent manner and decrease the release of the proinflammatory cytokine, IFN-γ. To address the role of NK cells in PD pathogenesis, NK cell function was investigated in a preformed fibril α-syn-induced mouse PD model. Our studies demonstrate that in vivo depletion of NK cells in a preclinical mouse PD model resulted in exacerbated motor deficits and increased phosphorylated α-syn deposits. Collectively, our data provide a role of NK cells in modulating synuclein pathology and motor symptoms in a preclinical mouse model of PD, which could be developed into a therapeutic for PD and other synucleinopathies.
The Increased Bone Mass in ΔFosB Transgenic Mice Is Independent of Circulating Leptin Levels (2002)

Transgenic mice overexpressing deltaFosB, a naturally occurring splice variant of FosB, develop an osteosclerotic phenotype. The increased bone formation has been shown to be due, at least in part, to autonomous effects of deltaFosB isoforms on cells of the osteoblast lineage. However, abdominal fat and marrow adipocytes are also markedly decreased in deltaFosB mice, leading to low serum leptin levels. Increased bone mass has been linked to the absence of leptin and leptin receptor signaling in ob/ob and db/db mice. Thus, in addition to affecting directly osteoblastogenesis and bone formation, deltaFosB isoforms might increase bone mass indirectly via a decrease in leptin. To test this hypothesis, we restored normal circulating levels of leptin in deltaFosB mice via sc implanted osmotic pumps. Complete histomorphometric analysis demonstrated that trabecular bone volume as well as dynamic parameters of bone formation was unchanged by this treatment in both deltaFosB transgenic mice and control littermates. This demonstration that restoring circulating levels of leptin in deltaFosB transgenic mice failed to rescue the bone phenotype further indicates that the marked increase in bone formation is autonomous to the osteoblast lineage.
Dynamic Bridge Response for a Bridge-friendly Truck (2004)

A truck with controlled semi-active suspensions traversing a bridge is examined for benefits to the bridge structure. The original concept of a road-friendly truck was extended to a bridge-friendly vehicle, using the same optimization tools. A half-car model with two independently driven axles is coupled with simply supported bridges (beam, slab model) with the span range from 5 m to 50 m. Surface profile of the bridge deck is either stochastic or in the shape of a bump or a pot in the mid-span. Numerical integration in the MATLAB/SIMULINK environment solves coupled dynamic equations of motion with optimized truck suspensions. The rear axle generates the prevailing load and to a great extent determines the bridge response. A significant decrease in contact road-tire forces is observed and the mid-span bridge deflections are on average smaller, when compared to commercial passive suspensions.
Markerless face capture and automatic model construction (2006)

Article Share on Markerless face capture and automatic model construction: part 1 Author: Chris Bregler NYU NYUView Profile Authors Info & Claims SIGGRAPH '06: ACM SIGGRAPH 2006 CoursesJuly 2006 Pages 12–eshttps://doi.org/10.1145/1185657.1185852Online:30 July 2006Publication History 0citation13DownloadsMetricsTotal Citations0Total Downloads13Last 12 Months1Last 6 weeks0 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Five-Year Outcomes of Hybrid Arch Frozen Elephant Trunk Repair With Novel Multibranched Hybrid Graft (2023)

The hybrid arch FET procedure with a novel hybrid graft is associated with good early and midterm outcomes. Longer term outcomes merit further investigation.
Respiratory Biofeedback Does Not Facilitate Lowering Arousal in Meditation Through Virtual Reality (2018)

The current study examined the effectiveness of respiratory biofeedback in lowering subjective and objective arousal after stress. Participants were presented with a meditation session in virtual reality while subjective and objective arousal were measured, the latter measured through ECG and EEG. Three conditions were used: (a) a respiratory biofeedback condition, in which visual feedback was paired to breathing; (b) a control feedback placebo condition, in which visual feedback was not paired to breathing; and (c) a control no-feedback condition, in which no visual feedback was used. Subjective and objective arousal decreased during meditation after stress in all conditions, demonstrating recovery after stress during meditation in virtual reality. However, the reduction in arousal (on all outcome measures combined and heart rate specifically) was largest in the control feedback placebo condition, in which no biofeedback was used, indicating that respiratory biofeedback had no additional value in reducing arousal. The findings of the current study highlight the importance of including a control feedback placebo condition in order to establish the exact additional value of biofeedback and offer insights in applying cost-effective virtual reality meditation training.
Successful Lightwand-Guided Intubation in a Patient with Long Standing Ankylosing Spondylitis Who Had Failed Intubation with Other Intubation Tools (2018)

Tracheal intubation in patients with cervical arthroplasty with occlusion of the upper airway frequently poses great difficulty. The purpose of this case study was to discuss lightwand tracheal intubation in patients with ankylosing spondylitis (AS) through exploring a successful lightwand-guided intubation case of a patient with AS. The patient was a 61-year-old male suffering from a fixed extension-flexion deformity that affected mobility in his entire spine. Any methods including GlideScope, I-gel were failed. Tracheal intubation using lightwand was only successful. Based on this case, we would like to suggest that using a lightwand in cases of AS may be appropriate.
Neurohormonal Changes After Implantation of a Left Ventricular Assist System (1998)

In patients with left ventricular dysfunction, neurohormonal levels are valuable indicators of the severity of heart disease and prognosis. For patients with severe left ventricular dysfunction, left ventricular assist systems (LVAS) are effective as short-term bridges to heart transplantation and are currently being investigated for long-term use. Unknown, however, are the effects of mechanical unloading of the left ventricle on neurohormone levels during the initial weeks after LVAS implantation, and whether these changes are similar to the neurohormonal level decreases observed after cardiac transplantation. This study was undertaken to determine the effect of LVAS support on plasma norepinephrine (PNE) levels during the initial weeks after device implantation. The PNE levels in five consecutive patients with left ventricular dysfunction were measured within 1 week after LVAS implantation and every week thereafter for 5 weeks. Significant decreases in PNE levels were observed after 3 weeks of LVAS support. After 5 weeks of LVAS support, PNE levels had decreased to near normal. For patients with severe left ventricular dysfunction, the improved prognosis after LVAS support may be due in part to the normalization of neurohormonal levels. The findings indicate that PNE levels may be of value in determining whether a patient can be weaned from LVAS support.
Innentitelbild: Chloride‐Bridged Dinuclear Rhodium(III) Complexes Bearing Chiral Diphosphine Ligands: Catalyst Precursors for Asymmetric Hydrogenation of Simple Olefins (Angew. Chem. 29/2016) (2016)

Er schießt und trifft! Effiziente Rhodium(III)-Katalysatoren für die asymmetrische Hydrierung einfacher Olefine ohne steuernde Gruppen beschreiben K. Mashima et al. in der Zuschrift auf S. 8439 ff. Die chlorverbrückten zweikernigen Rhodium(III)-Komplexe mit chiralen Diphosphanliganden liefern bessere Ergebnisse als die entsprechenden Rhodium(I)-Katalysatoren bei der asymmetrischen Hydrierung von (E)-Propen-1,2-diyldibenzol und Derivaten sowie von Allylalkoholen, Alkenylboranen und ungesättigten cyclischen Sulfonen.
Effects of Bactericera cockerelli Herbivory on Volatile Emissions of Three Varieties of Solanum lycopersicum (2019)

Domesticated tomato (<i>Solanum lycopersicum</i> L.) crops have presented an increased susceptibility to pests under field and greenhouse conditions. Among these pests is tomato/potato psyllid, <i>Bactericera cockerelli</i> Sulc (Hemiptera: Triozidae), a major pest in solanaceous crops. In this study, we evaluated volatile organic compound (VOC) emissions from the headspace in three healthy varieties of tomato plants (Floradade, Micro-Tom and wild) under greenhouse conditions using solid-phase microextraction and gas chromatography-mass spectrometry (SPME/GC-MS). Later, independent bioassays were performed to evaluate VOC emissions with three varieties infested with nymphs of <i>B. cockerelli</i>. The results in healthy plants showed markedly different VOC profiles in each variety (14 compounds for wild, 17 for Floradade and 4 for Micro-Tom). Plants infested with nymphs showed changes in VOC emissions distinctly in Floradade and wild varieties. We suggest that these qualitative differences in VOC profiles by the degree of domestication could explain the preferences of <i>B. cockerelli</i>.
Effects of replacing fish meal with poultry by-product meal and soybean meal and reduced protein level on the performance and immune status of pond-grown sunshine bass (Morone chrysops × M. saxatilis) (2010)

Two primary ways to achieve low-cost, nutritionally efficacious diets for sunshine bass (Morone chrysops × M. saxatilis) are to decrease crude protein (CP) levels and the use alternative animal or plant ingredients to partially, or totally, replace fish meal. A 459-day feeding trial was conducted with juvenile (35 g) sunshine bass to evaluate growth, feed efficiency, size distribution at harvest, immune function status and body composition when fed diets containing soybean meal (SBM), feed-grade poultry by-product meal (PBM), and supplemental methionine as complete replacements for menhaden fish meal (MFM) at 300 g kg−1 diet, while simultaneously reducing dietary crude protein (CP; 320, 360, and 400 g kg−1). The feeding trial was conducted in 12, 0.04-ha earthen ponds stocked at a rate of 300 per pond (3000/ac). At 400 g kg−1 dietary protein, there were no differences in responses between fish fed the diet containing MFM or the diet in which MFM was completely replaced with PBM and supplemental methionine on a digestible protein basis. However, final mean weight, percentage weight gain, specific growth rate, and protein efficiency ratio were linearly related (P < 0.10) to dietary protein level in the diets while no significant differences were found in feed intake and feed conversion ratio. The expected odds of fish at harvest being classified into larger size categories (> 680 g) decreased as dietary protein level decreased based on ordinal logistic regression. There were no significant relationships between body compositional indices and dietary treatments. Body fat ranged from 56 g kg−1 to 62 g kg−1, single fillets ranged from 28% to 30%, and livers ranged from 2.45% to 2.62% of body weight across treatments. Fillet protein concentration was positively linear and quadratic for protein level in the diet but fillet moisture, lipid and ash did not differ among diets. Total serum protein, immunoglobulin and lysozyme activity decreased linearly with decreasing diet protein level. These results suggest that complete replacement of MFM with feed grade PBM and supplemental methionine is possible in diets for sunshine bass and that further reductions in dietary protein level may be possible with amino acid supplementation.
Highly Anisotropic, Highly Transparent Wood Composites (2016)

For the first time, two types of highly anisotropic, highly transparent wood composites are demonstrated by taking advantage of the macro-structures in original wood. These wood composites are highly transparent with a total transmittance up to 90% but exhibit dramatically different optical and mechanical properties.
Femoral Prosthesis Version Angle Calculation from a Sagittal Plane Radiographic Projection of the Femur (2012)

Femoral prosthesis version angles can be accurately determined using this technique.
A case study of API redesign for improved usability (2008)

As software grows more complex, software developers' productivity is increasingly defined by their ability to effectively reuse code. Even APIs (application programming interfaces) and other code explicitly intended for reuse are often difficult and time consuming for developers to use. This paper describes the user-centered design and evaluation process we evolved in redesigning SAP's BRFplus - a business rules engine, whose API was created for platform development, but which is now also increasingly being used by application developers - even though it was not initially designed with their specific needs in mind. Our API redesign attempts to take both the initial as well as the new emergent user requirements into account. A usability evaluation of our proposed changes to the API suggests that our user-centered design process was successful in helping to create an API that significantly improved users' productivity and better matches the different users' needs.
Femtosecond white-light continuum generation in a Ti:sapphire oscillator (1998)

We present a femtosecond white-light Ti:sapphire oscillator obtained by intra-cavity continuum generation. Wavelengths as far as 460 nm on the visible and above 1 μm on the near-infrared side are available without amplification and with no external elements such as a fiber. The potentialities of this new source are demonstrated in a two-color pump-probe experiment.
FRAME-tags: genetically encoded fluorescent markers for multiplexed barcoding and time-resolved tracking of live cells (2021)

ABSTRACT Cellular barcodes offer critical tools for tracking cellular identity in biological systems. Although genetically encoded fluorescent barcodes are ideal for real-time tracking, their scalability is constrained by the broad, overlapping emission spectra characteristic of fluorescent proteins (FPs). Here, we describe a palette of genetically encoded fluorescent barcodes called FRAME-tags, which break this scalability barrier by encoding barcode identity as unique FP expression ratios. FRAME-tags use −1 programmed ribosomal frameshifting RNA motifs to precisely control the translational output of multiple FPs from a single mRNA, leading to extremely narrow and resolvable ratios of the corresponding cellular fluorescence distributions. With this platform, we constructed 20 resolvable FRAME-tags in yeast using just two FPs, and further demonstrated that 100 or more distinguishable FRAME-tags could be made by the addition of a third FP. We used FRAME-tags to map the dynamic fitness landscape of yeast co-cultures, and to characterize the expression pattern of 20 yeast promoters in multiplex across diverse conditions. FRAME-tags offer a valuable new tool for cellular barcoding that enables time-resolved characterization of complex biological systems using widely available fluorescence detection techniques and a minimal number of spectral channels.
Relationship Between Vibrations and Mechanical Seal Life in Centrifugal Pumps (2007)

A reduction of vibrations in mechanical seals increases the life of the seals in centrifugal pumps by minimizing fatigue damage. Mechanical seals consist of two smooth seal faces. One face is stationary with respect to the pump. The other rotates. Between the faces a fluid film evaporates as the fluid moves radially outward across the seal face. Ideally, the film evaporates as it reaches the outer surface of the seal faces, thereby preventing leakage from the pump and effectively lubricating the two surfaces. Relative vibrations between the two surfaces affect the fluid film and lead to stresses on the seal faces, which lead to fatigue damage. As the fluid film breaks down, impacts between the two seal faces create tensile stresses on the faces, which cycle at the speed of the motor rotation. These cyclic stresses provide the mechanism leading to fatigue crack growth. The magnitude of the stress is directly related to the rate of crack growth and time to failure of a seal. Related to the stress magnitude, vibration data is related to the life of mechanical seals in pumps.
Impact of photon recycling and luminescence coupling on III–V single and dual junction photovoltaic devices (2015)

Modeling single junction solar cells composed of III–V semiconductors such as GaAs with the effects of photon recycling yields insight into design and material criteria required for high efficiencies. For a thin-film single junction GaAs cell to reach 28.5% efficiency, simulation results using a recently developed model which accounts for photon recycling indicate that Shockley–Read–Hall (SRH) lifetimes of electrons and holes must be longer than 3 and 1 μs, respectively, in a 2-μm thin active region, and that the native substrate must be removed such that the cell is coupled to a highly reflective rear-side mirror. The model is generalized to account for luminescence coupling in tandem devices, which yields direct insight into the top cell’s nonradiative lifetimes. A heavily current mismatched GaAs/GaAs tandem device is simulated and measured experimentally as a function of concentration between 3 and 100 suns. The luminescence coupling increases from 14% to 33% experimentally, whereas the model requires increasing electron and hole SRH lifetimes to explain these results. This could be an indication of the saturating defects which mediate the SRH process. However, intermediate GaAs layers between the two subcells may also contribute to the luminescence coupling as a function of concentration.
Safety and Tolerability of Fremanezumab for the Prevention of Migraine: A Pooled Analysis of Phases 2b and 3 Clinical Trials (2019)

Fremanezumab is a generally safe and well-tolerated preventive therapy for migraine in adults.