gebhart/patrepeval huggingface dataset:
Epigenetic Alterations and Prenatal Maternal Depression (2017)

Major depressive disorder of the mother affects 6 to 17% of pregnancies worldwide and can lead to negative outcomes, such as preterm delivery and later mental health problems of the child. It has been proposed that developmental programming has long-lasting effects in the offspring that might be mediated by epigenetic mechanisms, such as DNA methylation. Altered stress regulation or impaired immunological function of the mother can potentially affect DNA methylation processes of the fetus, changing gene expression levels in utero. These underlying biological processes can be tested in animal models, where pharmacological experiments using epigenetic drugs can prove causality. Recent human studies show that DNA methylation changes of hypothesis-driven candidate gene regions, such as the promoter of the glucocorticoid receptor and the serotonin transporter, were associated with maternal depression in peripheral tissue samples of newborns' cord blood, infants' saliva, or adults' peripheral blood. In addition, epigenome-wide association studies using blood cells show modest but significant changes in a subset of genes involved in immune functions. These DNA methylation changes were found mainly in enhancers, which point to regulatory effects in gene expression. Limited number of studies using brain tissue showed a significant overlap of differentially methylated genes in the different studies. In conclusion, prenatal maternal depression can induce covalent modifications in the offspring's DNA, which are detectable at birth in leukocytes and could be potentially present in other tissues, consistent with the hypothesis that system-wide epigenetic changes are involved in life-long responses to the psychosocial environment in utero. Birth Defects Research 109:888-897, 2017. © 2017 Wiley Periodicals, Inc.
Chirp Z-driven split-step propagation algorithms for AOA analysis (2009)

Parabolic Wave Equation (PWE) algorithms are widely used to model electromagnetic wave propagation in diverse environments. In most applications only the amplitude of received field is of interest, but the computed fields also contain phase information, which can subsequently be used for evaluating the effectiveness of Angle-of-Arrival (AOA) algorithms. In this paper, we use the chirp Z-transform, which does interpolation of complex field values over a course grid generated by FFT, and evaluate its performance on the AOA estimation in a practical setting.
Motion Data Based Construction Worker Training Support Tool: Case Study of Masonry Work (2018)

Motion Data Based Construction Worker Training Support Tool: Case Study of Masonry Work JuHyeong Ryu, Lichen Zhang, Carl T. Haas and Eihab Abdel-Rahman Pages 1079-1084 (2018 Proceedings of the 35th ISARC, Berlin, Germany, ISBN 978-3-00-060855-1, ISSN 2413-5844) Abstract: Construction work involves a number of repetitive and physically demanding tasks. Exposure to these labor intensive tasks with awkward postures result in an increase in biomechanical risk factors that may lead to work-related musculoskeletal disorders (WMSDs). Thus, it is essential to provide training for apprentice-level workers to adopt safe working postures. Recent advancements in sensing technologies have enabled us to automatically collect body motion data and analyze posture. The present work presents an automated posture assessment method using inertial measurement units (IMUs) allowing for in-depth ergonomic analysis via kinematic data. A case study on masonry work was performed and body motion data from masons with varying experience levels were collected. For the posture analysis, we first investigated the risk of working posture between experience groups using observation-based posture assessment methods (RULA and REBA), then compared the assessment scores between experience groups. Finally, a prototype training tool based on working posture was introduced. The experimental results show that the automated collection and analysis of motion data can provide greater understanding of working postures adopted by workers with different experience levels with the potential to be used as a training tool in apprenticeship programs. Keywords: Construction management, Automation, Masonry, Risk assessment method, RULA, REBA, Training tool, Motion capture system DOI: https://doi.org/10.22260/ISARC2018/0150 Download fulltext Download BibTex Download Endnote (RIS) TeX Import to Mendeley
Coordinating and supramolecular prospects of unsymmetrically substituted carbohydrazides (2020)

Unsymmetrically substituted carbohydrazides serve as multifunctional ligands, practicing their chelating and supramolecular roles with<italic>cis</italic>-dioxomolybdenum(<sc>vi</sc>) cationic core and the Lindqvist anion.
Atlas-based registration parameters in segmenting sub-cortical regions from brain MRI-images (2009)

Multi-atlas segmentation has been proved to perform well in segmenting sub-cortical structures from images. In this work, we study different components of multi-atlas segmentation and propose new techniques to improve the segmentation accuracy. We found that the use of gradient information in addition to standard normalised mutual information increases the registration accuracy. We also studied different techniques to select atlases in the multi-atlas segmentation. In addition, the expectation maximisation algorithm was used to combine multi-atlas and intensity model information. The average similarity index obtained for six subcortical structures was 0.84.
Nd:YAG Laser Welding of Zinc-coated Steel Sheet (1998)

&lt;div class="htmlview paragraph"&gt;This paper describes the lap welding of Zinc-coated steel sheet using a high power continuous wave YAG laser. The well-known problem of welding the Zinc-coated sheet is related to the low boiling point of zinc compared with the melting point of steel. During lap welding, zinc coating at the interface vaporize rapidly and causes defects&lt;sup&gt;&lt;span class="xref"&gt;1)&lt;/span&gt;&lt;span class="xref"&gt;2)&lt;/span&gt;&lt;/sup&gt;.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;In this study, therefore, lap welding was performed by YAG laser. The effects of type of coating layer, welding conditions, tensile strength and corrosion resistance after electro-deposition was examined.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;It was found that the weldability of coated steel is different by type of coating. Zn-Ni coated steel showed good weldability, but galvanealed steel inevitably pore pits with no gap set up. These defects not only lower the strength of joint, but also produce irregular bead where easily corroded after electro-deposition.&lt;/div&gt;
Enhanced human bone marrow mesenchymal stromal cell adhesion on scaffolds promotes cell survival and bone formation (2017)

Around 10% of skeletal fractures do not heal correctly causing nonunion. An approach involving mesenchymal stromal cells (MSC) associated with biomaterials emerges as an innovative strategy for bone repair. The diversity of scaffolds is a source of heterogeneity for bone formation efficiency. In order to better determine the characteristics of a powerful scaffold it is crucial to understand their relationship with cells after graft. Our results highlight that a biomaterial architecture similar to cancellous bone is important to promote MSC adhesion and ensure cell survival in vivo. Additionally, we demonstrated that the grafted MSC play a direct role coupled to a paracrine effect to enhance bone formation and that both of those roles are governed by the used scaffold.
Noninvasive prenatal testing beyond genomic analysis (2016)

This study reviews the evidence that demonstrates the potential utilities of cell-free fetal transcriptomic and methylomic analysis for the future assessment of pregnancy-associated disorders.
ChemInform Abstract: Second Generation Leukotriene Biosynthesis Inhibitors. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
T2 estimates in healthy and diseased brain tissue: a comparison using various MR pulse sequences. (1986)

Fourteen patients and five healthy individuals underwent magnetic resonance (MR) imaging to determine an effective multiple spin echo pulse sequence for estimating T2. Lesions examined included infarction, glioma, multiple sclerosis, and acute hematoma. A pulse repetition time (TR) of 1,500 msec and echo delays (TEs) of 25, 50, 75, and 100 msec were used. Computed T2 images were derived from all four echoes, the first two echoes, and the first and fourth echoes. T2 values were obtained from specific brain locales using region-of-interest analysis. Use of either the first two echoes or the first and fourth in the T2 fit provided T2 estimates which closely correlated with that of the four-echo analysis. The noise level in T2 maps constructed from the 25- and 100-msec echoes was modestly (typically 10%) higher than that from four echoes; noise level from the 25- and 50-msec echoes was markedly higher, typically 60%. This behavior is remarkably consistent with that predicted from theory. All 19 subjects displayed consistent relative T2 values for specific brain structures; in 13, the absolute T2 values fell within a limited range. Despite the high sensitivity of T2 images, their specificity in the detection of most brain disease appears limited except in acute intracerebral hematoma, which exhibited a decreased T2 relaxation time using high-field-strength MR imaging.
Ceramide induces interleukin 6 gene expression in human fibroblasts. (1995)

We previously reported that ceramide, the immediate product of sphingomyelin hydrolysis, increases in response to interleukin (IL)-1 beta and plays a role in modulating IL-1 beta-mediated prostaglandin E2 production and cyclooxygenase gene expression in human fibroblasts (Ballou, L. R., C. P. Chao, M. A. Holness, S. C. Barker, and R. Raghow. 1992. J. Biol. Chem. 267:20044-20050). Here we describe the effects of ceramide in another IL-1 beta-mediated process in these cells, the induction of IL-6 production. We found that submicromolar concentrations of C2-ceramide induced IL-6 gene expression and protein production as effectively as IL-1 beta. Both D-erythro-C2-ceramide (a cell-permeable analogue of natural ceramide) and D-threo-C2-ceramide were potent inducers of IL-6 production, while neither L isomer of ceramide was effective. Compared with IL-1 beta-induced IL-6 production, cells treated with ceramide or exogenous sphingomyelinase induced 82 and 50% of maximal IL-1 beta-induced IL-6 levels by 6 h, respectively; by 24 h all three treatments induced similar levels of IL-6 production. Ceramide-induced IL-6 messenger RNA could be detected within 1 h of treatment and reached maximal levels by 24 h. These findings suggest that ceramide may play a role in the regulation of IL-6 gene expression.
Dual‐wideband dual‐polarized rhombic antenna array for base‐station applications (2022)

Abstract A compact dual‐wideband dual‐polarized antenna array with a narrow beam and low side‐lobe level for indoor base‐station applications is presented. Four higher‐band dipole elements are inserted inside four lower‐band rhombic‐arranged dipole elements. Dipole elements for each band are excited by two 1‐to‐4 power dividers with equal magnitude and phase. By using this scheme, stable narrow radiation patterns with low side‐lobe levels both in the horizontal and vertical planes are obtained over the dual‐frequency bands. For verification, a dual‐wideband rhombic antenna array with bandwidths of 49.3% (0.64–1.06 GHz) and 52.3% (1.61–2.75 GHz) for VSWR &lt; 1.5 is designed. It has a stable radiation pattern with 3‐dB beamwidths of around 33° and low side‐lobe levels of less than −22 dB both in the horizontal and vertical planes.
Image segmentation by reaction-diffusion bubbles (2002)

Figure-ground segmentation is a fundamental problem in computer vision. The main difficulty is the integration of low-level, pixel-based local image features to obtain global object-based descriptions. Active contours in the form of snakes, balloons, and level-set modeling techniques have been proposed that satisfactorily address this question for certain applications. However, these methods require manual initialization, do not always perform well near sharp protrusions or indentations, or often cross gaps. We propose an approach inspired by these methods and a shock-based representation of shape in terms of parts, protrusions, and bends. Since initially it is not clear where the objects or their parts are, parts are hypothesized in the form of fourth order shocks randomly initialized in homogeneous areas of images. These shocks then form evolving contours, or bubbles, which grow, shrink, merge, split and disappear to capture the objects in the image. In the homogeneous areas of the image bubbles deform by a reaction-diffusion process. In the inhomogeneous areas, indicated by differential properties computed from low-level processes such as edge-detection, texture, optical-flow and stereo, etc., bubbles do not deform. As such, the randomly initialized bubbles integrate low-level information and, in the process, segment the figures from the ground.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Energy Spotlight (2021)

ADVERTISEMENT RETURN TO ISSUEPREVEnergy FocusNEXTEnergy SpotlightAdvances in Lithium Batteries and Perovskite Solar CellsXiaolin LiXiaolin LiMore by Xiaolin Lihttp://orcid.org/0000-0002-7728-0157, Lioz EtgarLioz EtgarMore by Lioz Etgarhttp://orcid.org/0000-0001-6158-8520, and Omar MohammedOmar MohammedMore by Omar Mohammedhttp://orcid.org/0000-0001-8500-1130Cite this: ACS Energy Lett. 2021, 6, 5, 2003–2005Publication Date (Web):May 3, 2021Publication History Received26 April 2021Accepted26 April 2021Published online3 May 2021Published inissue 14 May 2021https://pubs.acs.org/doi/10.1021/acsenergylett.1c00875https://doi.org/10.1021/acsenergylett.1c00875newsACS PublicationsCopyright © Published 2021 by American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1661Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (2 MB) Get e-AlertscloseSUBJECTS:Carrier dynamics,Electrical conductivity,Metals,Mobility,Solar cells Get e-Alerts
MnO<sub>2</sub> Nanotube-Based NanoSearchlight for Imaging of Multiple MicroRNAs in Live Cells (2017)

Sensitive assay and imaging of multiple low-abundance microRNAs (miRNAs) in living cells remain a grand challenge. Herein, based on polyelectrolyte-induced reduction, a facile approach has been proposed to synthesize novel MnO<sub>2</sub> nanotubes. Owing to the remarkably strong fluorescence quenching ability, low cytotoxicity, and excellent colloid stability, the as-prepared MnO<sub>2</sub> nanotubes showed great potential for simultaneous detection and imaging of multiple miRNAs in vitro and in situ in living cells for the first time. Besides, MnO<sub>2</sub> nanotubes can be reduced to Mn<sup>2+</sup> by intracellular acid pH or glutathione, which may serve as an activatable contrast reagent for MRI. Therefore, the MnO<sub>2</sub> nanotube-based probes, termed "NanoSearchlight", provide a promising, multimodal imaging tool for precise and accurate diagnosis and prognosis of cancers.
On the Preparation of MoS<sub>2</sub> Catalysts from MoS<sub>3</sub> (1975)

We have examined the effect of reducing MoS 3 in hydrogen in the range 450–800 °C on the properties of the resulting MoS 2 catalyst. The appearance of rhombohedral MoS 2 at 800 °C is disputed. Instead, an 'overreduced' catalyst containing some Mo metal and hexagonal MoS 2 was formed. Catalytic activity in thiophene hydrodesulfurization was insensitive to pretreatment.
Ballistic Electron Transport on Periodic and Quasi-Periodic Triangular Lattices of Scatterers (1991)

We have studied electron transport properties on an artificial periodic and quasi-periodic array of scatterers. Scatterers are introduced in two-dimensional electron gas of a GaAs-AlGaAs heterojunction by employing electron beam and dry etching, or by damaging of direct focused ion beam irradiation. Novel magnetoresistance oscillations are observed at low magnetic field. It was found that the dominant features in the data arise from commensurate classical orbit.
Strategic Arrivals into Queueing Networks: The Network Concert Queueing\n Game (2011)

Queueing networks are typically modelled assuming that the arrival process is\nexogenous, and unaffected by admission control, scheduling policies, etc. In\nmany situations, however, users choose the time of their arrival strategically,\ntaking delay and other metrics into account. In this paper, we develop a\nframework to study such strategic arrivals into queueing networks. We start by\nderiving a functional strong law of large numbers (FSLLN) approximation to the\nqueueing network. In the fluid limit derived, we then study the population game\nwherein users strategically choose when to arrive, and upon arrival which of\nthe K queues to join. The queues start service at given times, which can\npotentially be different. We characterize the (strategic) arrival process at\neach of the queues, and the price of anarchy of the ensuing strategic arrival\ngame. We then extend the analysis to multiple populations of users, each with a\ndifferent cost metric. The equilibrium arrival profile and price of anarchy are\nderived. Finally, we present the methodology for exact equilibrium analysis.\nThis, however, is tractable for only some simple cases such as two users\narriving at a two node queueing network, which we then present.\n
Chemical characterization and oxidative stability of castor oil grown in Morocco (2015)

Seed oil of Castor bean (Ricinus communis L) grown in Morocco were analyzed for their main chemical composition and for their oxidative stability. Gas chromatography revealed that the major fatty acids were ricinoleic, linoleic, and oleic acids (75.0%, 9.7%, and 7. 7% respectively). Seed oil was also found to be rich in sterols (2210 mg/kg) with a predominance of β-sitosterol (1041 mg/kg). The tocopherols marker δ-tocopherol accounted for 43.1 mg/kg. Oxidative stability of castor oil was measured at 110 °C at the air flow rate of 20 L/hw, castor oil was more stable than many other oils with 35.5 h. The results achieved suggest that the castor bean might be an important source of vegetable oil for industrial uses.
Multifunctional performance of carbon nanotubes and graphene nanoplatelets reinforced PEEK composites enabled via FFF additive manufacturing (2019)

The study is focused on multifunctional performance of carbon nanotubes (CNT) and Graphene nanoplatelets (GNP) reinforced PEEK composites enabled via fused filament fabrication (FFF) additive manufacturing (AM) utilizing in-house nanoengineered filaments. Thermo-physical, mechanical and wear characteristics of electro-conductive PEEK nanocomposites are reported. The coefficient of thermal expansion (CTE) is found to decrease by 26% and 18% with the incorporation of 5 wt% GNP and 3 wt% CNT into PEEK polymer, respectively. The decrease in CTE provides better dimensional stability to resulting nanocomposite structures. Due to uniform dispersion of CNT and GNP in the PEEK matrix, the crystallization temperature and degree of crystallinity are both increased. The 3D printed PEEK nanocomposites reveal interfacial voids between the beads and intra-bead pores and thus exhibit lower density compared to that of the 3D printed neat PEEK. Young's and storage moduli are found to increase by 20% and 66% for 3 wt% CNT loading and by 23% and 72% for 5 wt% GNP loading respectively. However, the PEEK nanocomposites exhibit similar tensile strength to that of neat PEEK. The coefficient of friction obtained from fretting wear tests is found to decrease by 67% and 56% for 1 wt% CNT and 3 wt% GNP loaded PEEK nanocomposites, respectively and the decrease is attributed to reduced hardness and increased porosity. Multifunctional performance of carbon nanostructures reinforced AM-enabled PEEK composites demonstrated here makes them suitable for a range of applications such as orthopedics, oil and gas, automotive, electronics and space.
An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4 (2022)

Activity-based protein profiling (ABPP) is a versatile strategy for identifying and characterizing functional protein sites and compounds for therapeutic development. However, the vast majority of ABPP methods for covalent drug discovery target highly nucleophilic amino acids such as cysteine or lysine. Here, we report a methionine-directed ABPP platform using Redox-Activated Chemical Tagging (ReACT), which leverages a biomimetic oxidative ligation strategy for selective methionine modification. Application of ReACT to oncoprotein cyclin-dependent kinase 4 (CDK4) as a representative high-value drug target identified three new ligandable methionine sites. We then synthesized a methionine-targeting covalent ligand library bearing a diverse array of heterocyclic, heteroatom, and stereochemically rich substituents. ABPP screening of this focused library identified 1oxF11 as a covalent modifier of CDK4 at an allosteric M169 site. This compound inhibited kinase activity in a dose-dependent manner on purified protein and in breast cancer cells. Further investigation of 1oxF11 found prominent cation-π and H-bonding interactions stabilizing the binding of this fragment at the M169 site. Quantitative mass-spectrometry studies validated 1oxF11 ligation of CDK4 in breast cancer cell lysates. Further biochemical analyses revealed cross-talk between M169 oxidation and T172 phosphorylation, where M169 oxidation prevented phosphorylation of the activating T172 site on CDK4 and blocked cell cycle progression. By identifying a new mechanism for allosteric methionine redox regulation on CDK4 and developing a unique modality for its therapeutic intervention, this work showcases a generalizable platform that provides a starting point for engaging in broader chemoproteomics and protein ligand discovery efforts to find and target previously undruggable methionine sites.