gebhart/patrepeval huggingface dataset:
Comparative evaluation of soft-switching concepts for bi-directional buck&amp;#x002B;boost dc-dc converters (2010)

Soft-switching techniques are an enabling technology to further reduce the losses and the volume of automotive dc-dc converters, utilized to interconnect the high voltage battery or ultra-capacitor to the dc-link of a Hybrid Electrical Vehicle (HEV) or a Fuel Cell Vehicle (FCV). However, as the performance indices of a power electronics converter, such as efficiency and power density, are competing and moreover dependent on the underlying specifications and technology node, a comparison of different converter topologies naturally demands detailed analytical models. Therefore, to investigate the performance of the ARCP, CF-ZVS-M, SAZZ and ZCT-QZVT soft-switching converters, the paper discusses in detail the advantages and drawbacks of each concept, and the impact of the utilized semiconductor technology and silicon area on the converter efficiency. The proposed analytical models that correlate semiconductor, capacitor and inductor losses with the component volume furthermore allow for a comparison of power density and to find the η-ρ-Pareto-Front of the CF-ZVS-M converter.
Spreading of Viscous Fluid Drops on a Solid Substrate Assisted by Thermal Fluctuations (2005)

We study the spreading of viscous drops on a solid substrate, taking into account the effects of thermal fluctuations in the fluid momentum. A nonlinear stochastic lubrication equation is derived and studied using numerical simulations and scaling analysis. We show that asymptotically spreading drops admit self-similar shapes, whose average radii can increase at rates much faster than these predicted by Tanner's law. We discuss the physical realizability of our results for thin molecular and complex fluid films, and predict that such phenomenon can in principal be observed in various flow geometries.
New soft-output MLSE equalization algorithm for GSM digital cellular systems (2002)

We propose a new SO-MLSE (soft-output maximum likelihood sequence estimation) equalizer, which can be used in a GSM digital cellular system. It uses a complex correlation of the training sequence to obtain the channel information and the equalization is performed by MLSE using the Viterbi algorithm. In order to generate a soft-decision input to channel decoder (Viterbi decoder), the soft-output equalization algorithm is needed. The adopted algorithm doesn't require one to modify the structure of the HO-MLSE (hard output MLSE) equalizer, that is, the SO-MLSE equalizer can be implemented by adding a soft-output generation block to the HO-MLSE equalizer. This algorithm uses the outputs of a matched filter and the HO-MLSE equalizer. It turns out that the complexity of the proposed SO-MLSE equalizer is simpler than those of other SO-MLSE equalizers and its performance is almost the same as those of the others. Finally, the proposed SO-MLSE equalizer is also implemented as a prototype with the ADSP-2101 16-bits fixed point digital signal processing chip.
Multi-Physics Simulation Platform and Multi-Layer Metal Technology for CMOS-MEMS Accelerometer with Gold Proof Mass (2019)

This chapter describes technical features and solutions to realize a highly sensitive CMOS-MEMS accelerometer with gold proof mass. The multi-physics simulation platform for designing the CMOS-MEMS device has been developed to understand simultaneously both mechanical and electrical behaviors of MEMS stacked on LSI. MEMS accelerometer fabrication process is established by the multi-layer metal technology, which consists of the gold electroplating and the photo-sensitive polyimide film. The proposed MEMS accelerometers are fabricated and evaluated to verify the effectiveness of the proposed techniques regarding sub-1G MEMS and arrayed MEMS devices. The experimental results show that the Brownian noise of the sub-1G MEMS accelerometer can achieve 780 nG/(Hz)1/2 and the arrayed MEMS accelerometer has a wide detection, ranging from 1.0 to 20 G. Moreover, using the developed simulation platform, we demonstrate the proposed capacitive CMOS-MEMS accelerometer implemented by the multi-layer metal technology. In conclusion, it is confirmed that the multi-physics simulation platform and the multi-layer metal technology for the CMOS-MEMS device have a potential to realize a nano-gravity sensing technology.
Next century challenges (1999)

Article Next century challenges: data-centric networking for invisible computing: the Portolano project at the University of Washington Share on Authors: Mike Esler Department of Computer Science and Engineering, University of Washington, Seattle Department of Computer Science and Engineering, University of Washington, SeattleView Profile , Jeffrey Hightower Department of Computer Science and Engineering, University of Washington, Seattle Department of Computer Science and Engineering, University of Washington, SeattleView Profile , Tom Anderson Department of Computer Science and Engineering, University of Washington, Seattle Department of Computer Science and Engineering, University of Washington, SeattleView Profile , Gaetano Borriello Department of Computer Science and Engineering, University of Washington, Seattle Department of Computer Science and Engineering, University of Washington, SeattleView Profile Authors Info & Claims MobiCom '99: Proceedings of the 5th annual ACM/IEEE international conference on Mobile computing and networkingAugust 1999 Pages 256–262https://doi.org/10.1145/313451.313553Online:01 August 1999Publication History 85citation1,248DownloadsMetricsTotal Citations85Total Downloads1,248Last 12 Months16Last 6 weeks3 Get Citation AlertsNew Citation Alert added!This alert has been successfully added and will be sent to:You will be notified whenever a record that you have chosen has been cited.To manage your alert preferences, click on the button below.Manage my AlertsNew Citation Alert!Please log in to your account Save to BinderSave to BinderCreate a New BinderNameCancelCreateExport CitationPublisher SiteGet Access
Inflammatory response is elicited in human cerebrovascular endothelial cells stimulated with blood plasma obtained from Severe Sepsis patients (2012)

Mechanisms of sepsis‐associated encephalopathy (SAE) are largely un‐investigated, however, impaired function of cerebrovascular endothelium has been suggested to play a key role. Our recent findings indicate that Severe Sepsis in humans results in up‐regulation of 13 out of 42 pro‐inflammatory cytokines/chemokines analyzed in blood plasma (e.g. IL‐6, MCP‐1, MIP‐1, IL‐8, IP‐10). In this study we used immortalized human‐derived cerebrovascular endothelial cells (hCVEC) to assess activation/dysfunction of hCVEC in response to stimulation with plasma (20% vol/vol) obtained from either patients with Severe Sepsis (hSSP) or healthy controls. Stimulation of hCVEC with hSSP for 1hr resulted in hCVEC activation as evidenced by increased ROS production (DHR123 oxidation). Subsequently, stimulation of hCVEC with hSSP resulted in increased PMN adhesion to hCVEC under conditions of flow (shear stress 1dyn/cm 2 ) and increased hCVEC permeability as assessed by decreased transendothelial electric resistance. Interestingly, hSSP failed to induce activation of inflammation‐relevant transcription factor, NF‐κB (ELISA) following 1hr stimulation. In summary, our data indicate that pro‐inflammatory substance(s) present in human Severe Sepsis plasma induce activation/dysfunction of cerebrovascular endothelial cells, thus may contribute to the development of SAE (IRF 08‐10)
Enzymatic Production of<scp>l</scp>-Phenylalanine from<i>trans-</i>Cinnamic Acid by<i>Endomyces lindneri</i> (1987)

Journal Article Enzymatic Production of l-Phenylalanine from trans- Cinnamic Acid by Endomyces lindneri Get access Norimasa Onishi, Norimasa Onishi Central Research Laboratories of Ajinomoto Co., Inc., 1–1, Suzuki-cho, Kawasaki-ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar Kenzo Yokozeki, Kenzo Yokozeki Central Research Laboratories of Ajinomoto Co., Inc., 1–1, Suzuki-cho, Kawasaki-ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar Yoshiteru Hirose, Yoshiteru Hirose Central Research Laboratories of Ajinomoto Co., Inc., 1–1, Suzuki-cho, Kawasaki-ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar Koji Kubota Koji Kubota Central Research Laboratories of Ajinomoto Co., Inc., 1–1, Suzuki-cho, Kawasaki-ku, Kawasaki 210, Japan Search for other works by this author on: Oxford Academic Google Scholar Agricultural and Biological Chemistry, Volume 51, Issue 1, 1 January 1987, Pages 291–292, https://doi.org/10.1080/00021369.1987.10868013 Published: 01 January 1987 Article history Received: 07 October 1986 Published: 01 January 1987
A phase 1 study of fianlimab (anti-LAG-3) in combination with cemiplimab (anti-PD-1) in patients with advanced melanoma: Poor-prognosis subgroup analysis. (2023)

9548 Background: Co-blockade of LAG-3 improves the effectiveness of anti-PD-1 treatment (Tx) in advanced melanoma (Mel) patients (pts). We previously reported high clinical activity of the combination immunotherapy of anti-LAG-3 (fianlimab) and anti-PD-1 (cemiplimab) in pts (N = 80) with anti–PD-1/PD-ligand (L)1-naïve advanced Mel enrolled in two expansion phase 1 cohorts. The objective response rate (ORR) (N = 80) and disease control rate (DCR) was 63.8% and 80.0%, respectively with median duration of response (mDOR) not reached (NR). Factors associated with poor prognosis include elevated lactate dehydrogenase (LDH) levels and sites of metastases, including liver or other visceral organs (M1c). Here we present updated efficacy data in poor prognosis pts from three phase 1 advanced Mel expansion cohorts: cohort 6 and 15 of anti-PD-(L)1/systemic Tx-naïve pts and cohort 16 of pts previously exposed to adjuvant (adj) or neo-adj systemic Tx including anti-PD-1. Methods: Pts with advanced Mel (excluding uveal Mel) were treated with fianlimab 1600 mg + cemiplimab 350 mg intravenously every 3 weeks for 12 months (+ additional 12 months if clinically indicated). Tumor measurements were assessed by RECIST 1.1 every 6 weeks for 24 weeks, then every 9 weeks. Results: 40 pts each in cohort 6 and 15, and 18 pts in cohort 16 (total N = 98) were enrolled and treated with fianlimab + cemiplimab as of 01 Nov 2022 data cutoff. In the adj/neo-adj setting, 23.5% of pts had received prior systemic Tx for Mel including 15.3% with prior exposure to immune checkpoint inhibitors (iCPIs). Median follow up was 12.6 months and median Tx duration was 32.9 weeks. ORR among all 98 pts and in 15 pts with prior iCPIs was 61.2% and 60.0%, respectively. In pts with LDH &gt; upper limit of normal (ULN) (N = 32, 32.7%), ORR, DCR, and mDOR were 53.1%, 71.9%, and NR (95% CI, 7.4– not estimated [NE]), respectively, and median progression-free survival (mPFS) was 11.8 months (95% CI, 3.7–NE). In pts with liver mets at baseline (BL) (N = 21, 21.4%), ORR, DCR, and mDOR were 42.9%, 57.1%, and 9.0 months (95% CI, 2.8–NE), respectively, and mPFS was 4.2 months (95% CI, 1.2–NE). In pts with any M1c disease and LDH &gt; ULN at BL (N = 17, 17.3%), ORR, DCR, mDOR were 35.3%, 58.8%, and NR (95% CI, 5.7–NE), respectively, and mPFS was 7.1 months (95% CI, 1.2–NE). Overall, 43.9% and 32.7% of pts reported grade ≥3 Tx-emergent adverse events (TEAEs) and serious TEAEs. Correlative biomarkers analyses are in progress and will be included in the presentation. Conclusions: The combination of fianlimab and cemiplimab showed high activity in pts with advanced Mel and poor prognosis features at BL. The ORR and DCR observed in these subgroups compare positively with the available data for approved combinations of iCPIs in the same clinical setting. A phase 3 trial (NCT05352672) of fianlimab + cemiplimab in Tx-naïve advanced Mel pts is ongoing. Clinical trial information: NCT03005782 .
A custom-designed limited-angle actuator for an electromechanical engine valve drive. Part I: Conceptual design (2010)

Research has shown that variable valve timing (VVT) can improve significantly the performance of internal combustion (IC) engines, including higher fuel efficiencies, lower emissions, and larger torque outputs at each point of the engine map.To achieve independent and continuous VVT for each valve, an electromechanical valve drive (EMV) system was proposed previously, whose feasibility with low seating velocity had been demonstrated.In order to further improve the practicality of the EMV system, especially for a much smaller system package, a novel rotary actuator with limited angular range is proposed in this paper.Four main design challenges are discussed before a limited-angle actuator with a special yoke structure and a hollow basket-shaped aluminium-based armature is presented.Based on Maxwell simulation with optimized physical dimensions, the actuator is capable of meeting the time, power, torque, and size constraints.
Human-Centric Analytics and Systems Impacting Quality of Life: ECG Analytics and Beyond (2021)

With the proliferation of Internet of Things (IoT), sensor technologies and advancement in the analytics systems mainly in the form of deep learning algorithms, the long quest for developing human-centric applications like automated disease diagnosis, privacy-enabled analytics is becoming a reality. Knowledge-Driven Analytics and Systems Impacting Human Quality of Life (KDAH) is indeed an attractive proposition. For example, Phonocardiogram or heart sound-based detection of heart abnormality or Myocardial Infarction (MI) prediction using single lead Electrocardiogram (ECG) signals are signifying the capability of analytics algorithm to directly solve human-centric problems. We have proposed privacy-preserved analytics with phonocardiogram-based heart condition detection, established benchmark performance of MI detection using single lead ECG signals as well as demonstrated deep residual learning based algorithm to help carbon footprint management.
Efficient continuous collision detection for bounding boxes under rational motion (2006)

This paper presents a simple yet precise and efficient algorithm for collision prediction of two oriented bounding boxes under univariate (piecewise) rational motion. We present an analytic solution to the problem of finding the time of collision and the feature involved, or declaring that no collision should occur. Our solution can be applied to boxes of any size, under arbitrary rational rigid motion. The algorithm is based on the efficient examination of the Minkowski sum (MS) of the two boxes, using a spherical Gauss map dual representation, and a precise extraction of the collision time, if any, as a solution to a set of rational equations that are automatically derived
Costs of radium removal from potable water supplies. Final report (1977)

Myopathies are genetic or acquired disorders of skeletal muscle that lead to varying degrees of weakness, atrophy, and exercise intolerance. In theory, creatine supplementation could have a number of beneficial effects that could enhance function in myopathy patients, including muscle mass, strength and endurance enhancement, lower calcium levels, anti-oxidant effects, and reduced apoptosis. Patients with muscular dystrophy respond to several months of creatine monohydrate supplementation (~0.075-0.1 g/kg/day) with greater strength (~9%) and fat-free mass (~0.63 kg). Patients with myotonic dystrophy do not show as consistent an effect, possibly due to creatine transport issues. Creatine monohydrate supplementation shows modest benefits only at lower doses and possibly negative effects (cramping) at higher doses in McArdle's disease patients. Patients with MELAS syndrome show some evidence of benefit from creatine supplementation in exercise capacity, with the effects in patients with CPEO being less robust, again, possibly due to limited muscle creatine uptake. The evidence for side effects or negative impact upon serological metrics from creatine supplementation in all groups of myopathy patients is almost non-existent and pale in comparison to the very substantial and well-known side effects from our current chemotherapeutic interventions for some myopathies (i.e., corticosteroids).
Studies on the Control of Antibody Synthesis XI. Effect of Antigen on the Localization of Cells Secreting Different Avidity Antibodies (1977)

It was shown that rabbit popliteal lymph nodes draining the site of antigen injection tend to contain high avidity PFC while the PFC present in sites distant to the antigen injection tend to be of low avidity. When different doses of antigen are injected into the two rear footpads the popliteal node draining the side receiving the higher dose of antigen tends to contain more and higher avidity PFC. If antigen injections are given serially, 1 week apart, into different footpads, then the popliteal node draining the site of the first antigen injection tends to contain more and higher avidity PFC regardless of the dose of antigen used. Thus, antigen availability appears to be a critical factor in determining the localization of precursors of PFC. Following an injection of antigen, high avidity PFC (or their precursors) appear to be preferentially retained in the node draining the site of antigen injection; only low avidity PFC are found at distant sites. In addition, there is a depletion of the available pool of high avidity B-cell precursors of PFC so that a second injection of antigen, at a distant site, stimulates mainly low avidity PFC in the lymph nodes draining the site of the second antigen injection.
Formalizing and Verifying Workflows Used in Blood Banks (2014)

Abstract Blood banks use automation to decrease errors in delivering safe blood for transfusion. The Food and Drug Administration (FDA) of the United States and other organizations recommend blood banks to validate their computer system process, which is resource and labor intensive. For this reason, we have created a formal workflow model for blood bank operations and used an automated tool to verify that it satisfies safety properties. Our methodology started by understanding and gathering information about blood bank procedure. Then we mapped all procedures into processes in a workflow engine. Then we used the verification packages provided by the workflow engine to check the safety properties.
Haptic applications as physics teaching tools (2010)

Touch is one of the most important senses in our everyday life when exploring and experiencing the physical world. It is, however, rare that haptic applications have been used to support learning at school. This paper describes a case study on utilizing haptic applications in the 8 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sup> grade physics learning. The study was carried out in a close collaboration with teachers in a real teaching environment by observing pupils' reactions and comments and by gathering the experiences of the teacher and the pupils. The Density application and the Leverage application that offer force feedback with the low-cost No-vint Falcon device were implemented to help in understanding the physical phenomena. The results were positive in regard to utilizing the sense of touch to enhance and to concretize often abstract physical phenomena.
Corn Yield Response to Timing of Strip‐Tillage and Nitrogen Source Applications (2013)

Development of effective management practices to maximize corn ( Zea mays L.) production is important in poorly drained claypan soils due to their relatively low yield potential and vulnerability for environmental N loss. The objective of this 3‐yr study, conducted at one location was to determine whether an N management system with strip‐till (ST) and deep banding placement of polymer‐coated urea (PCU) could produce greater corn yields than no‐till (NT) systems with broadcasted non‐coated urea (NCU) or injected anhydrous ammonia (AA) with or without nitrapyrin with fall, early pre‐plant, or pre‐plant N applications. The experiment was a split‐plot design with N application dates as the main plot and eight N management systems (N source and tillage/N placement) as subplots. Nitrogen sources of PCU, NCU, and a non‐treated control (NTC) were used in conjunction with NT/surface broadcast and ST/deep band placement practices. Anhydrous ammonia was injected into a NT soil with or without nitrapyrin. Injecting AA into a NT soil with nitrapyrin at pre‐plant produced at least 2 Mg ha −1 greater corn yields than any of the management systems with a fall application during three wet years. When N was applied in the fall or at early pre‐plant, ST/deep banding of PCU and NCU produced yields similar to NT/injected AA with or without nitrapyrin. Strip‐tillage with deep banding of urea fertilizers may be a viable, high yielding alternative N management system in poorly drained claypan soils when tillage and N applications are done in fall.
The Effect of Concurrent Programming Idioms on Verification - A Position Paper (2015)

In recent years formal verification techniques have become an important part of the development cycle of concurrent software. In order to tackle the state explosion problem and verify larger systems, a great deal of work has been put into improving the scalability of verification tools. In this work, we seek to draw attention to an alternative/complementary approach to improving scalability, which sometimes receives less notice: the effect the concurrent programming model itself has on oneâs ability to verify programs encoded within it. Recent work suggests that a suitable choice of model, tailored to the problem at hand, may render the produced software more amenable to verification techniques. We recapitulate some recent and new results demonstrating this effect in programming models for discrete, synchronous reactive systems, and outline some directions for future work. We hope that the paper will trigger additional research on this important topic.
The emerging role of immune checkpoint inhibition in malignant lymphoma (2016)

To evade elimination by the host immune system, tumor cells commonly exploit physiological immune checkpoint pathways, restraining efficient anti-tumor immune cell function. Growing understanding of the complex dialog between tumor cells and their microenvironment contributed to the development of immune checkpoint inhibitors. This innovative strategy has demonstrated paradigm-shifting clinical activity in various malignancies. Antibodies targeting programmed death 1 and cytotoxic T-lymphocyte-associated protein-4 are also being investigated in lymphoid malignancies with varying levels of activity and a favorable toxicity profile. To date, evaluated only in the setting of relapsed or refractory disease, anti-programmed death 1 antibodies such as nivolumab and pembrolizumab show encouraging response rates particularly in classical Hodgkin lymphoma but also in follicular lymphoma and diffuse-large B-cell lymphoma. As the first immune checkpoint inhibitor in lymphoma, nivolumab was approved for the treatment of relapsed or refractory classical Hodgkin lymphoma by the Food and Drug Administration in May 2016. In this review, we assess the role of the pathways involved and potential rationale of checkpoint inhibition in various lymphoid malignancies. In addition to data from current clinical trials, immune-related side effects, potential limitations and future perspectives including promising combinatory approaches with immune checkpoint inhibition are discussed.
NT-501: an ophthalmic implant of polymer-encapsulated ciliary neurotrophic factor-producing cells. (2008)

Neurotech Pharmaceuticals Inc is developing NT-501, an implantable polymeric device containing a genetically modified cell line that secretes ciliary neurotrophic factor, for the potential treatment of retinitis pigmentosa (RP) and age-related macular degeneration (AMD). Phase III clinical trials for RP and a phase II clinical trial for dry AMD are ongoing. A phase I clinical trial showed that NT-501 treatment was well tolerated with variable, but positive improvements in visual acuity.