gebhart/patrepeval huggingface dataset:
Attenuation and efficacy of live-attenuated Rift Valley fever virus vaccine candidates in non-human primates (2018)

Rift Valley fever virus (RVFV) is an important mosquito-borne veterinary and human pathogen that has caused large outbreaks of severe disease throughout Africa and the Arabian Peninsula. Currently, no licensed vaccine or therapeutics exists to treat this potentially deadly disease. The explosive nature of RVFV outbreaks and the severe consequences of its accidental or intentional introduction into RVFV-free areas provide the impetus for the development of novel vaccine candidates for use in both livestock and humans. Rationally designed vaccine candidates using reverse genetics have been used to develop deletion mutants of two known RVFV virulence factors, the NSs and NSm genes. These recombinant viruses were demonstrated to be protective and immunogenic in rats, mice, and sheep, without producing clinical illness in these animals. Here, we expand upon those findings and evaluate the single deletion mutant (ΔNSs rRVFV) and double deletion mutant (ΔNSs-ΔNSm rRVFV) vaccine candidates in the common marmoset (Callithrix jacchus), a non-human primate (NHP) model resembling severe human RVF disease. We demonstrate that both the ΔNSs and ΔNSs-ΔNSm rRVFV vaccine candidates were found to be safe and immunogenic in the current study. The vaccinated animals received a single dose of vaccine that led to the development of a robust antibody response. No vaccine-induced adverse reactions, signs of clinical illness or infectious virus were detected in the vaccinated marmosets. All vaccinated animals that were subsequently challenged with RVFV were protected against viremia and liver disease. In summary, our results provide the basis for further development of the ΔNSs and ΔNSs-ΔNSm rRVFV as safe and effective human RVFV vaccines for this significant public health threat.
<i>In situ</i> video observation of 180° domain kinetics in congruent LiNbO3 crystals (1999)

We report in situ observation of the nucleation and growth of ferroelectric 180° domains in congruent LiNbO3 crystals. The domains nucleate and grow as six-sided polygons. The wall velocity measured at a constant field shows a spike-like behavior with time, suggesting a strong pinning–depinning type of growth mechanism. This behavior is similar to the corresponding transient current measurement which also shows current spikes during domain reversal.
Développement durable et approche par les capabilités (2020)

contribution to the UN Global Sustainable Development Report 2015, Sustainable development knowledge platform
Entropy and the timing capacity of discrete queues (2003)

Queueing systems which map Poisson input processes to Poisson output processes have been well-studied in classical queueing theory. This paper considers two discrete-time queues whose analogs in continuous-time possess the Poisson-in-Poisson-out property. It is shown that when packets arriving according to an arbitrary ergodic stationary arrival process are passed through these queueing systems, the corresponding departure process has an entropy rate no less (some times strictly more) than the entropy rate of the arrival process. Some useful by-products are discrete-time versions of: (i) a proof of the celebrated Burke's (1956) theorem, (ii) a proof of the uniqueness, amongst renewal inputs, of the Poisson process as a fixed point for exponential server queues proposed by Anantharam (1993), and (iii) connections with the timing capacity of queues described by Anantharam and Verdu (1996).
Lattice relaxation in type I gas hydrates (1991)

Abstract Computer simulations have been used to examine the approximations upon which the van der Waals‐Platteeuw theory of hydrate stability is based, and in particular, the extent to which the water lattice relaxes about the guest molecules. It is found that the behavior of the water lattice depends significantly on both the nature and number of guest molecules present—an effect that is neglected in the van der Waals‐Platteeuw theory. The simulations also indicate an important role for the repulsive guest‐host interactions in generating the mechanical stability of gas hydrates in the bulk. On the basis of these simulations, it is conjectured that surface interactions (particularly at a water/guest interface) are fundamental to the phase behavior of gas hydrates.
Response of n-type mc-Si to large variations of gettering and hydrogenation (2007)

The minority charge carrier recombination behaviour of n-type multicrystalline silicon wafers was systematically studied through microwave detected photoconductance decay, on as-grown samples, on samples submitted to phosphorus diffusion step and on samples after gettering and hydrogenation processes.First, we show that extreme gettering parameters (high temperature, high phosphorous-dosing of the wafer surface, long process) result in a significantly better cleaning of the edge zone of ingots, compared to typical phosphorous emitter diffusion.On the other hand, it results in less cleaning of the bulk silicon matrix, and somewhat more decoration of extended crystal defects.Second, we show that there is much improvement possible by enhanced hydrogenation of the wafer.This improvement applies to extended crystal defects but especially to bulk silicon matrix.Bulk silicon lifetime (in low defect crystals) continues to improve with increasing hydrogenation, in the wafers that we investigated e.g. from values around 150 s after typical industrial hydrogenation, to 270 s after the highest hydrogenation dose which we investigated.
Incommensurately Modulated Polar Structures in Antiferroelectric Tin‐Modified Lead Zirconate Titanate: II, Dependence of Structure‐Property Relations on Tin Content (1998)

Studies of the structure‐property relations in Pb 0.98 Nb 0.02 ‐ [(Zr 1‐ x Sn x ) 0.97 Ti 3 ] 1‐ z O 3 (PZST x /3/2) were performed for 0 &lt; x &lt; 0.50 by transmission electron microscopy, dielectric spectroscopy, and electrically induced polarization and strain methods. As the tin content increased, a general sequence of changes in phase stability was observed, including (i) a ferroelectric rhombohedral (FE r ) phase ( x &lt; 0.15), (ii) a coexistence of FE r and antiferroelectric incommensurate (AFE in ) states ( x = 0.15), and (iii) an AFE in state ( x &gt; 0.15). Evidence will be presented that incommensurately modulated structures become pinned into long‐lived metastable states by quenched tin impurities, rather than evolving toward a commensurate phase. Maximum electrically induced strains (epsilon) and polarizations ( P ) were found in the compositional range of x similar/congruent 0.15, where FE r and AFE in regions coexisted. Values of epsilon as large as 0.5% were found at field strengths of &lt;80 kV/cm. In addition, these studies demonstrated evidence for two electrically induced phase transitions ( x = 0.15): (i) an antiferroelectric‐ferroelectric (AFE‐FE) transition near 40 kV/cm, and (ii) a secondary ferroelectric‐ferroelectric (FE‐FE) transition near 60‐80 kV/cm. The dominate contribution to epsilon was associated with the secondary transition, whereas the dominate contribution to P was associated with the first. For x &lt; 0.15, evidence of an induced FE‐FE transition was found. For x &gt; 0.15, an induced AFE‐FE transition was evident. However, no indications of a secondary FE‐FE transition were observed. Large epsilon values were not induced until field levels significantly greater than that required to induced polarization saturation were obtained, which indicates a decoupling of epsilon and P.
Catecholamine Uptake, Storage, and Regulated Release by Ovarian Granulosa Cells (2008)

Catecholamines present in the mammalian ovary are involved in many normal aspects of ovarian functions, including initial follicle growth, steroidogenesis, and pathological states such as polycystic ovary syndrome. Sympathetic nerve fibers are the largest source of norepinephrine (NE), but not the only one. Surgical denervation of the rat ovary reduces, but does not eliminate, the ovarian content of NE. The aim of this work was to explore which intraovarian cells may participate in the ovarian NE homeostasis and the mechanisms involved. It was found that denervated rat ovaries can take up NE and cocaine considerably, decreased its uptake, suggesting involvement of catecholamine transporters. Granulosa cells of rat ovarian follicles present dopamine transporter and NE transporter. Their functionality was confirmed in isolated rat granulosa cells while cocaine blocked the uptake of NE. Furthermore, the presence of the vesicular monoamine transporter 2, together with the exocytotic protein (synaptosome-associated protein of 25 kDa) in granulosa cells, implies catecholamine storage and regulated release. Regulated calcium-dependent release of NE was shown after depolarization by potassium, implying all neuron-like cellular machinery in granulosa cells. These results in rats may be of relevance for the human ovary because dopamine transporter, NE transporter, vesicular monoamine transporter 2, and synaptosome-associated protein of 25-kDa protein and mRNA are found in human ovarian follicles and/or isolated granulosa cells. Thus, ovarian nonneuronal granulosa cells, after taking up catecholamines, can serve as an intraovarian catecholamine-storing compartment, releasing them in a regulated way. This suggests a more complex involvement of catecholamines in ovarian functions as is currently being recognized.
Evaluation of the chloride migration and carbonation coefficients of Belgian ready mixed and precast concrete for a performance-based design (2019)

In the design of Belgian concrete structures, durability aspects are currently assessed based on a deemed-to-satisfy approach according to the standards NBN EN 206-1 (2014) and NBN B 15-001 (2012). As this design method hinders innovation, the trend worldwide is to move towards durability-based design of concrete structures. Within the Tetra project "DurOBet", a quantitative method has been developed to implement a performance-based design for durability in Belgium. For the damage mechanisms chloride ingress and carbonation, reference values have been set up in function of the exposure class, cement type, concrete cover, initial chloride content and curing time. The reference values were deduced from available data and additional test results obtained within the "DurOBet" project, using a probabilistic approach. In the study as presented here, twelve ready mixed and precast concrete mixtures were tested and evaluated with regard to their resistance to chloride and CO2 ingress. A comparison was made between the evaluation of their durability based on a deemed-to-satisfy approach and a performance-based approach. It was verified to what extent the actual migration coefficient and carbonation coefficient meet the predefined reference values for the different exposure classes taking into account a design service life of 50 years.
A low Power ECG signal processor for ambulatory arrhythmia monitoring system (2010)

An ECG signal processor (ESP) is proposed for ambulatory arrhythmia monitoring systems. The ESP consists of three heterogeneous processors and performs filtering, data compression, ECG classification, and encryption. A data reduction scheme, consisting of skeleton and Huffman coding, are employed to reduce the on-chip memory capacity and memory access power. Clock gating and voltage scaling are also applied to reduce the power consumption. The ESP consumes 1.26-µW at 0.7V, while providing real time signal processing.
An Exome-Wide Sequencing Study of the GOLDN Cohort Reveals Novel Associations of Coding Variants and Fasting Plasma Lipids (2019)

<b>Background:</b> Associations of both common and rare genetic variants with fasting blood lipids have been extensively studied. However, most of the rare coding variants associated with lipids are population-specific, and exploration of genetic data from diverse population samples may enhance the identification of novel associations with rare variants. <b>Results:</b> We searched for novel coding genetic variants associated with fasting lipid levels in 894 samples from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) with exome-wide sequencing-based genotype data. In single variant tests, one variant (rs11171663 in <i>ITGA7</i>) was associated with fasting triglyceride levels (<i>P</i> = 7.66E-08), explaining approximately 3.2% of the total trait variance. In gene-based tests, we found statistically significant associations between <i>ITGA7</i> (<i>P</i> = 1.77E-07) and <i>SLCO2A1</i> (<i>P</i> = 7.18E-07) and triglycerides, as well as between <i>POT1</i> (<i>P</i> = 3.00E-07) and low-density lipoprotein cholesterol. In another independent replication cohort consisting of 3,183 African American samples from Hypertension Genetic Epidemiology Network (HyperGEN) and the Genetic Epidemiology Network of Arteriopathy (GENOA), the top genes achieved <i>P</i>-values of 0.04 (<i>ITGA7</i>), 0.08 (<i>SLCO2A1</i>), and 0.02 (<i>POT1</i>). In GOLDN, gene transcript levels of <i>ITGA7</i> and <i>SLCO2A1</i> were associated with fasting triglycerides (<i>P</i> = 0.07 and <i>P</i> = 0.02), highlighting functional relevance of our findings. <b>Conclusion:</b> In this study, we present preliminary evidence of novel rare variant determinants of fasting lipids, and reveal potential underlying molecular mechanisms. Moreover, these results were replicated in an independent cohort. Our findings may inform novel biomarkers of disease risk and treatment targets.
Critical ReRAM Stack Parameters Controlling Complimentary versus Bipolar Resistive Switching (2015)

The thickness of the oxygen scavenging metal layer, forming the Ohmic contact in HfOx and TaOx VCM-type Metal-Oxide ReRAM cells, was found to be the critical experimental parameter controlling stable bipolar resistive switching versus the occurrence of single-cell complimentary switching. It is argued that the physically controlling parameter is the effective work function (a)symmetry between top and bottom electrode contact of the ReRAM cell. For a thin metal cap layer, oxidation increases the effective work function changing from Ohmic to a more blocking contact behavior.
A Novel 3-Way Dual-Band Doherty Power Amplifier for Enhanced Concurrent Operation (2021)

This article presents the architecture and design methodology for a new type of dual-band Doherty power amplifier (DB-DPA), referred to as 3-Way DB-DPA, which consists of a main amplifier for each band and an auxiliary amplifier handling both bands. The 3-Way DB-DPA improves the average drain efficiency in concurrent dual-band operation compared to the traditional 2-Way DB-DPA, by avoiding early clipping in the main amplifiers, while benefiting from load—pulling from the auxiliary power amplifier (PA). This improvement is verified in theory and simulation at the current-source reference planes and in measurement with a fabricated 1.5- and 2-GHz dual-band PA. A statistical analysis using 2-D continuous-wave (CW) signals with long-term evolution (LTE) probability distribution functions (PDFs) is performed and demonstrated an improvement in the concurrent average efficiency by 15 percentage points compared to the conventional 2-Way DB-DPA. In nonconcurrent operation, the measured CW drain efficiency in the lower band (1.5 GHz) is 82.8% at peak and 66.6% at 9.6-dB backoff, and the measured CW drain efficiency in the upper band (2.0 GHz) is 70.0% at peak and 48.4% at 9.4-dB backoff. The CW concurrent-balanced drain efficiency reaches 66.2/52.0% in the 3-Way DB-DPA at 3-/6-dB backoff. In single-band operation at 1.5/2.0 GHz, the average power and average drain efficiency after linearization by digital predistortion (DPD) are 35.1/37.4 dBm and 65.0/53.7%, respectively, for an LTE signal with 10-MHz bandwidth and 6.1-dB peak-to-average power ratio (PAPR). In concurrent operation, the 3-Way DB-DPA is driven by two 10-MHz LTE uncorrelated signals at 1.5 GHz with 6.86-dB PAPR and at 2.0 GHz with 6.26-dB PAPR, and the average total power and average concurrent drain efficiency after DPD are 37.5 dBm and 54.24%, respectively.
Study of the crystal structures and nonstoichiometry in the system Cs3Sc2Cl9-CsScCl3 (1980)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudy of the crystal structures and nonstoichiometry in the system Cs3Sc2Cl9-CsScCl3Kenneth R. Poeppelmeier, John D. Corbett, Tom P. McMullen, David R. Torgeson, and Richard G. BarnesCite this: Inorg. Chem. 1980, 19, 1, 129–134Publication Date (Print):January 1, 1980Publication History Published online1 May 2002Published inissue 1 January 1980https://pubs.acs.org/doi/10.1021/ic50203a028https://doi.org/10.1021/ic50203a028research-articleACS PublicationsRequest reuse permissionsArticle Views272Altmetric-Citations28LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Multimode Lasing in All-Solution-Processed UV-Nanoimprinted Distributed Feedback MAPbI<sub>3</sub> Perovskite Waveguides (2023)

In this work, we present an all-solution fabrication approach for external second-order 1D distributed feedback (DFB) gratings using soft UV-nanoimprint lithography (UV-NIL) above archetypical methylammonium lead iodide (MAPbI3) perovskite films. This high-throughput method can be carried out in an ambient environment and requires only slightly elevated temperatures as low as 70 °C, gentle imprint pressure, and the use of compatible UV-NIL resin. Under stripe-shaped optical excitation, we observe simultaneously occurring optical phenomena in our high-gain strong-scattering perovskite films, namely amplified spontaneous emission, random lasing, and 1D DFB lasing. In pursuit of distinguishing these mechanisms, we explore far-field emission patterns and output polarization. Additionally, the DFB lasing is hardly attenuated when a thin absorbing indium tin oxide (ITO) film, commonly used as an electrode in fully contacted electrical devices, is inserted between the perovskite film and the DFB grating. As a result, we reproducibly achieve single and multimode, low-threshold (below 100 μJ·cm–2), narrow linewidth (below 0.2 nm), and strongly polarized (extinction ratio above 50) optically pumped DFB lasing for MAPbI3 waveguides with and without an adjacent ITO layer. We believe that the proposed resonator integration approach can be extended toward complete electrically active devices, enabling an alternative integration scheme to achieve current-injection lasing.
Effect of bicarbonate on CO2 electroreduction over cathode catalysts (2021)

CO2 electroreduction (CO2 ER) using renewable energy is ideal for mitigating the greenhouse effect and closing the carbon cycle. Bicarbonate (HCO3−) is most commonly employed as the electrolyte anion because it is known to facilitate CO2 ER. However, its dynamics in the electric double layer remains obscure and requires more in-depth investigation. Herein, we investigate the refined reduction process of bicarbonate by employing in situ attenuated total reflectance surface-enhanced infrared absorption spectroscopy. By comparing the product distributions in Ar-saturated KCl and KHCO3 electrolytes, we confirmed CO production from HCO3− in the absence of an external CO2 source. Notably, in contrast to an electric compulsion, negatively charged HCO3− anions were found to accumulate near the electrode surface. A reduction mechanism of HCO3− is proposed in that HCO3− is not adsorbed over a catalyst, but may be enriched near the electrode surface and converted to CO2 and react over Au and Cu electrodes. The dependence of the CO2 ER activity on the local HCO3− concentration was subsequently discovered, which was in turn dependent on the bulk HCO3− concentration and cathodic potential. In particular, the local HCO3− concentration was limited by the cathodic potential, leading to a plateau in the CO2 ER activity. The proposed mechanism provides insights into the interaction between the catalyst and the electrolyte in CO2 ER.
Controllability of periodic systems: continuous and discrete (2004)

The controllability of both continuous and discrete periodic systems are evaluated. The controllability for continuous periodic systems is extended to unit period control, and these results are then directly extended to discrete periodic systems. An assessment is made on retaining periodic system controllability during discretisation, resulting in the conclusion that there is no loss in the controllability of linear periodic systems during discretisation when using a nonequidistant sampling pattern.
The Question of the “Divine Status” of the Davidic Messiah (2020)

Abstract This article addresses the question whether there are compelling reasons that suggest that the Davidic messiah in the Hebrew Bible must be a divine being, as opposed to having merely a human-heroic status. It presents a number of arguments that support a divine understanding in some of the texts that can be related to the expectation of a future Davidic messiah. It also draws attention to the fact that in many instances the divine interpretation of the relevant texts is possible or likely rather than necessary and that it is only the combination of a number of suggestive passages that allow the reader to discern the divine character of the Davidic messiah. The investigation is located in the broader context of the question of monotheism in the Hebrew Bible and draws some conclusions concerning the theological consequences of the affirmation of the divinity of the Davidic messiah.
Evaluation of a Bearingless PM Motor With Wide Magnetic Gaps (2010)

A new noncontact drive system has been developed employing a consequent-pole-type bearingless permanent magnet (PM) motor and a thrust magnetic bearing. This bearingless motor has a wide magnetic gap. The wide magnetic gap may cause a decrease in radial magnetic suspension force because of an increase in magnetic reluctance. A thrust magnetic bearing is installed at the end of the shaft because strong thrust force exists in centrifugal pump applications. In this paper, the magnetic suspension forces and rotation characteristics of the experimental prototype are evaluated while the rotor is magnetically suspended. Experimental results are also compared to the calculated ones using the finite-element method. It is demonstrated that the developed consequent-pole-type bearingless PM motor possesses sufficient magnetic suspension force for noncontact operation.
ChemInform Abstract: Pd(II)‐Catalyzed Carbonylation of Unsaturated Polyols and Aminopolyols (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Solving Shared Problems at the Food, Energy, and Water Nexus (2021)

A 15-year-old partnership among Chinese and U.S. scientists studying challenges in our food, energy, and water systems has revealed that solutions are best achieved through international collaboration.