gebhart/patrepeval huggingface dataset:
Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1 (2009)

miR-126, miR-24 and miR-23a are selectively expressed in microvascular endothelial cells in vivo, whereas miR-145 is expressed in pericytes. miR-145 targets the hematopoietic transcription factor Fli1 and blocks migration in response to growth factor gradients. Our findings have implications for vascular disease and provide necessary information for future drug design against miRNAs with selective expression in the microvasculature.
Estimating divergently routed nonlinearly interfering channel powers using cross phase modulation (2014)

The deployment of coherent transceivers in legacy networks requires significant investment in installation. We propose a method enabling autonomous (re-)configuration of an optical channel, which would be advantageous in legacy networks and necessary in proposed future networks utilizing a flexible frequency grid and software defined components such as reconfigurable optical add drop multiplexers (ROADM). We consider potential interfering optical channels propagating with the prospective channel along part of the fiber link which are dropped before arrival at the receiver. The method uses a commercially available line card transmitting a 40Gbit/s polarization multiplexed quadrature phase shift keying (PM-QPSK) probe channel to characterize an optical channel. The power of the nearest neighboring channels is then inferred by examining its bit error rate (BER) which is impacted by cross phase modulation (XPM) from the aggressor channels. In a 4 node network with 2 ROADMs using up to 6 aggressor OOK channels, we successfully deduce the neighboring channel power down to -2 dBm, and an extra improvement down to -3.5 dBm is gained, by measuring at an offset to the international telecommunication union (ITU) grid which also reveals inequality in neighbor channel powers.
Compatibility and viscoelastic properties of brominated isobutylene‐<i>co</i>‐<i>p</i>‐methylstyrene rubber/tackifier blends (2008)

Abstract Brominated isobutylene‐ co‐p ‐methylstyrene (BIMS) rubber has been blended with hydrocarbon resin tackifier and alkyl phenol formaldehyde resin tackifier, and the compatibility between the blend components has been systematically evaluated. Dynamic mechanical analysis (DMA) and differential scanning calorimetry (DSC) studies show that BIMS rubber and hydrocarbon resin tackifier blends are compatible at all blend proportions studied. However, BIMS rubber and phenol formaldehyde resin blends exhibit very limited compatibility with each other and phase separation even at very low phenolic tackifier concentration. Morphological studies of the rubber–resin blends by scanning electron microscopy (SEM) corroborate well with the DMA and DSC results. From the DMA frequency sweep and temperature sweep studies, it is shown that the hydrocarbon resin tackifier acts as a diluent and causes a decrease in the storage modulus values (by reducing the entanglement and network density) in the rubbery plateau region. On the other hand, phenol formaldehyde resin behaves in the way similar to that of the reinforcing filler by increasing the storage modulus values (by increasing the entanglement and network density) in the rubbery plateau zone. The relaxation time estimated from the different zones of frequency sweep master curves provides information about the influence of the two tackifiers on the viscoelastic properties of the BIMS rubber in the respective zones. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Diffusion sélective pour l'analyse de séquences IRM cardiaques marquées (2005)

National audience
Hot Corrosion Behavior of Coated Covalent Ceramics (1988)

Ceramic thin films were deposited on hot‐pressed silicon nitride and silicon carbide substrates to provide corrosion protection to the underlying material. High‐purity silicon nitride, silicon carbide, and silicon oxynitride (SiO 2 /Si 3 N 4 composite) coatings were deposited by plasma‐enhanced chemical vapor deposition and rf sputtering to form an effective diffusion barrier for cation migration into the silica corrosion product. Preliminary results indicated that the extent of corrosion in Na 2 SO 4 melts at T = 900°, 950°, and 1000°C was dependent on the outward diffusion of cations in the grain‐boundary phase and the crystallinity of the grain‐boundary phase in the uncoated ceramics. Accelerated corrosion occurred in these ceramics because of breakdown of the protective silica film formed on the surface. Corrosion rates in Na 2 SO 4 melts were reduced by separating the oxide grain‐boundary phases from the corrosion products with high‐purity covalent ceramic coatings. 1988 The American Ceramic Society
Design of high D.O.F. mobile micro robot using electrical resistance control of shape memory alloy (2007)

Shape-memory alloy(SMA) is a suitable actuator for a micro mobile robot due to its size and weight. However, length of SMA actuators is known to be nonlinear and hysteretic. We can control SMA’s shape analogously to its electrical resistance. This paper presents a platform to construct high degree of freedom robots with tendons of SMA actuators. We incorporate coil shape SMA as variable length tendons of tendon-driven robots. By controlling electrical resistance of SMA tendons, we can control posture of the robot structure in model-based method. A method to resolve electrical resistance for control from given posture of a high degree of freedom robot by using model of SMA and the robot is proposed. A small electrical system for high D.O.F. robots is also developed. As an application of our system, we show a four-legged robot with 16 D.O.F. joints and 24 SMA tendons.
Post-Streptococcal Antibodies Are Associated with Metabolic Syndrome in a Population-Based Cohort (2011)

Post-streptococcal anti-PDI antibodies are associated with metabolic syndrome regardless of fasting insulin and CRP levels. Whereas these data are in line with a growing body of evidence linking infections, immunity and metabolism, additional studies are necessary to establish the post-streptococcal-metabolic syndrome association.
DEVELOPING AND USING BIOASSAYS TO SCREEN FOR PSA RESISTANCE IN NEW ZEALAND KIWIFRUIT (2015)

The bacterial pathogen Pseudomonas syringae pv. Actinidiae (Psa), biovar 3 causes a destructive disease of kiwifruit. Psa was first identified in New Zealand on 5 November 2010 on Actinidia chinensis 'Hort16A' (Zespri Gold) kiwifruit vines in the Te Puke region and has now spread to 81% of kiwifruit orchards. Intensive spray programmes based upon Actigard® and copper-based products have been implemented by growers, but the high usage of copper products is unsustainable. Therefore, breeding new cultivars with greater resistance to Psa has become a priority. Plant and Food Research (PFR) has developed a range of bioassays to characterise kiwifruit germplasm (e.g., tissue culture plantlets, potted seedling and mature vines) for resistance to Psa. The 'woody-stem bioassay' measures Psa lesion development and bacterial proliferation on wound-inoculated cane segments (bud wood). The measurements are combined to provide a woody stem bioassay index (WSBI) which ranges from 0 (resistant) to 100 (susceptible). Since its deployment in July 2012, the woody-stem bioassay has been successfully used to determine the Psa resistance status of five commercial cultivars, 75 pre-commercial clonal selections and >2,000 parental and seedling kiwifruit from the PFR breeding programme. A 'green stem-stab' bioassay was also developed to compare susceptibility of actively growing shoots. Soft stems or shoots are inoculated using a toothpick dipped in Psa suspension and then scored for a range of symptoms (e.g. lesion size and stem collapse) after 2-3 weeks incubation in high humidity. This bioassay has been used to evaluate the Psa-resistance status of seedlings from selected crosses, including populations being interrogated for molecular markers of Psa resistance. Seedlings from inter specific-crosses (A. chinensis × A. arguta) exhibited greater resistance to Psa than A. chinensis × A. chinensis seedlings. These bioassays are currently being utilised for identifying genotypes within the PFR kiwifruit breeding programme that are resistant to Psa.
Substrate Distortion and the Catalytic Reaction Mechanism of 5-Carboxyvanillate Decarboxylase (2015)

5-Carboxyvanillate decarboxylase (LigW) catalyzes the conversion of 5-carboxyvanillate to vanillate in the biochemical pathway for the degradation of lignin. This enzyme was shown to require Mn(2+) for catalytic activity and the kinetic constants for the decarboxylation of 5-carboxyvanillate by the enzymes from Sphingomonas paucimobilis SYK-6 (kcat = 2.2 s(-1) and kcat/Km = 4.0 × 10(4) M(-1) s(-1)) and Novosphingobium aromaticivorans (kcat = 27 s(-1) and kcat/Km = 1.1 × 10(5) M(-1) s(-1)) were determined. The three-dimensional structures of both enzymes were determined in the presence and absence of ligands bound in the active site. The structure of LigW from N. aromaticivorans, bound with the substrate analogue, 5-nitrovanillate (Kd = 5.0 nM), was determined to a resolution of 1.07 Å. The structure of this complex shows a remarkable enzyme-induced distortion of the nitro-substituent out of the plane of the phenyl ring by approximately 23°. A chemical reaction mechanism for the decarboxylation of 5-carboxyvanillate by LigW was proposed on the basis of the high resolution X-ray structures determined in the presence ligands bound in the active site, mutation of active site residues, and the magnitude of the product isotope effect determined in a mixture of H2O and D2O. In the proposed reaction mechanism the enzyme facilitates the transfer of a proton to C5 of the substrate prior to the decarboxylation step.
Enhancing the Photocatalytic Activity of TiO2/Na2Ti6O13 Composites by Gold for the Photodegradation of Phenol (2022)

This study aims to synthesize Au/TiO2/Na2Ti6O13 composites to reduce the occurrence of recombination and increase photocatalytic activity in phenol degradation. Gold was used due to its high stability and strong surface plasmon resonance (SPR) properties which make it operate effectively in the visible light spectrum. The prepared composites were characterized using XRD, SEM, TEM, FTIR, and DRS. The results showed that the composite consisted of rutile TiO2 with a crystal size of 38–40 nm and Na2Ti6O13 with a crystal size of 25 nm. The gold in the composite has a crystallite size of 16–19 nm along with the percentage of gold added. Morphological analysis shows that the composite has the form of inhomogeneous spherical particles with gold spread among composites with sizes less than 20 nm. FTIR analysis showed the presence of Na–O and Ti–O–Ti bonds in the composite. The best composite was 3% Au/TiO2/Na2Ti6O13 which had high crystallinity, small particle size, and bandgap energy of 2.59 eV. Furthermore, it had an efficiency 205% better than without gold. After that, cost estimation is proposed as a large-scale application. This study describes the total cost, break-even analysis, and payback analysis for the commercialization needs of the designed photocatalytic catalyst.
Bis(trimethyltin)bis-(η-toluene)-hafnium and -zirconium; X-ray crystal structure of the hafnium compound (1981)

Treatment of the compound [Hf(η-C6H5Me)2-PMe3] with hexamethylditin gives the compound [Hf(η-C6H5Me)2(SnMe3)2], a d2, bent bis-arene derivative, the crystal structure of which has been determined; the analogous zirconium compound is similarly prepared.
Dielectric properties of Ti2AlC and Ti2AlN MAX phases: The conductivity anisotropy (2008)

The optical properties of Ti2AlN and Ti2AlC were determined in the 2–80 eV energy range by electron energy loss spectroscopy and in the visible-ultraviolet range, from 1.6 to 5.5 eV, by spectroscopic ellipsometry. Both experimental techniques are angular resolved and in very good agreement over their overlapping energy range. We observe a dependence of the dielectric function as a function of the crystallographic orientation of the crystals. In particular, we notice a shift of the energy position of the plasmon absorption of Ti2AlC with respect to Ti2AlN. Moreover, a drastic change is also observed in the shape of the dielectric function as a function of the composition (or valence electron concentration). The dielectric functions are fitted to an empirical semiclassic Drude–Lorentz model to obtain physical parameters such as the relaxation times. These microscopic parameters are then used in a macroscopic model to yield the transport properties such as the static conductivity as function of the crystal orientation. Ti2AlN is found to be a better conductor than Ti2AlC in all orientations, which is consistent with experimental measurements. A comparison of the electrical and optical properties of these two compounds is made in terms of different electronic properties and interband-intraband transitions deduced from our model.
Striatal Serotonin Receptors and Dopamine Release (2000)

To the Editors : Lucas and Spampinato (1) described our study (2) as showing that ketanserin, a preferential serotonin 5-HT2A antagonist, failed to modify the enhancement of striatal dopamine (DA) efflux induced by intrastriatal infusion of 1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane (DOI). We, in fact, stated the following : “Local application of 1 mM DOI increased DA release to 250 ± 90% of control values. Pretreatment with ketanserin blocked this increase and also reduced the basal release of DA to 27 ± 5% of control values.” Thus our observations did not support Lucas and Spampinato's conclusion that 5-HT2A receptors are not involved in mediating the enhancement of DA release by DOI.
Stability and Biological Activity of Native and Recombinant Ricin Toxin B-Chain (1994)

Non-glycosylated recombinant ricin B-chain (rRTB) expressed in E. coli was compared with native RTB for stability and lectin activity. The heterodimer comprising native A-chain (RTA) and rRTB was further tested for cytotoxicity. These studies indicate that the asialofetuin binding activity, absorption spectra and binding with 8-anilino-1-naphthalene sulphonic acid (ANS) of rRTB are unchanged, whereas the fluorescence spectra are slightly modified compared to native RTB. Tryptic digestion showed that rRTB is more sensitive to degradation than native RTB. Cytotoxicity of native ricin is ten times greater than that of the heterodimer of native ricin A-chain with rRTB. These results suggest that glycosylation is not necessary for protein stability but prolongs resistance to proteolytic degradation in cells.
Detection of amyloid in Alzheimer’s disease with positron emission tomography using [11C]AZD2184 (2009)

[(11)C]AZD2184 is a promising radioligand for detailed mapping of Abeta amyloid depositions in Alzheimer's disease, due to low non-specific binding, high signal to background ratio and reversible binding as evident from early peak equilibrium.
Record nuclear polarization in optically pumped 3He gas using a high power LNA laser (1992)

Optical pumping is an efficient method for creating nuclear polarization M in a gas of 3 He. M is first achieved in the metastable 2 3 S state and then transfered to the ground state. Polarized 3 He has numerous applications: quantum fluids, precision magnetometry, nuclear targets, etc. Much progress in achieving high values of M has resulted from the development of efficient IR lasers capable of exciting the 2 3 S –2 3 P 3 He transition at 1.08 μm. Using a novel lamp pumped LNA laser delivering 5 W cw, we have achieved M &gt;85% for samples in the torr pressure range. To measure M we have developed an accurate technique based on the change as a function of M of the ratio between σ and π polarized light absorbed from a weak; probe beam by the 2 3 S metastable atoms. The probe was delivered by a single mode tunable diode pumped LNA laser that was frequency modulated by using an étalon mounted on a galvoplate. M was also measured by monitoring the circular polarization of the 668 nm line emitted by the dis charge. Experimental and theoretical results on the optimization of the pumping will be presented, and the laser systems will be discussed.
Reevaluation of the conclusion that IRES-activity reported within the 5′ leader of the <i>TIF4631</i> gene is due to promoter activity (2004)

We previously reported that the 5' leader of the mRNA-encoding initiation factor eIF4G in Saccharomyces cerevisiae can function as a translational enhancer and as an internal ribosome entry site (IRES) when tested in cells. However, Verge and colleagues recently suggested that this sequence does not facilitate translation initiation, but inhibits translation in vitro and has promoter activity when tested in cells. We disagree with these conclusions and respond by showing that the data are most consistent with an internal initiation mechanism.
Antibody characterization using immunosignatures (2020)

Therapeutic monoclonal antibodies have the potential to work as biological therapeutics. OKT3, Herceptin, Keytruda and others have positively impacted healthcare. Antibodies evolved naturally to provide high specificity and high affinity once mature. These characteristics can make them useful as therapeutics. However, we may be missing characteristics that are not obvious. We present a means of measuring antibodies in an unbiased manner that may highlight therapeutic activity. We propose using a microarray of random peptides to assess antibody properties. We tested twenty-four different commercial antibodies to gain some perspective about how much information can be derived from binding antibodies to random peptide libraries. Some monoclonals preferred to bind shorter peptides, some longer, some preferred motifs closer to the C-term, some nearer the N-term. We tested some antibodies with clinical activity but whose function was blinded to us at the time. We were provided with twenty-one different monoclonal antibodies, thirteen mouse and eight human IgM. These antibodies produced a variety of binding patterns on the random peptide arrays. When unblinded, the antibodies with polyspecific binding were the ones with the greatest therapeutic activity. The protein target to these therapeutic monoclonals is still unknown but using common sequence motifs from the peptides we predicted several human and mouse proteins. The same five highest proteins appeared in both mouse and human lists.
REAL-WORLD IMPACT CONDITIONS FOR RUN-OFF-THE-ROAD ACCIDENTS (DISCUSSION AND CLOSURE) (1986)

Information is presented on real-world impact conditions for accidents involving roadside objects and features based on in-depth accident data. Of particular interest are the distributions of impact speed and angle for various functional classes. Other considerations relating to impact conditions, such as vehicle orientation at impact, are also discussed. The potential applications of the information presented in this paper are illustrated with two examples, one involving the full-scale crash test matrix and the other involving benefit-cost procedures.
Stand-off dislocations at a twist grain boundary in gold as seen via high-resolution transmission electron microscopy (2013)

The present study applies high-resolution transmission electron microscopy with a combination of geometric phase analysis to characterize atomic structures of a twist grain boundary in gold, illuminating the presence of misfit dislocations with a stand-off distance from the grain boundary. The formation of the stand-off misfit dislocations is attributed to a difference in shear modulus between the two grains bordering the grain boundary, which originates in elastic anisotropy of Au.
Automatic Transmit Power Control of a Digital Fixed Wireless Link with Co-Channel Interference (2007)

In this paper, a study is presented of the dynamic behavior of an automatic transmit power control (ATPC) loop in a single fixed wireless system (FWS) link subject to multipath fading and an uncorrelated co-channel interferer that does not use ATPC (this represents a so-called non-ATPC FWS link or a fixed satellite link). Fundamental questions include the sensitivity of an ATPC link to multipath interference and the co-channel interference that may be caused by a non-ATPC interferer. In the context of the present project, a good example of a non-ATPC interferer is a fixed satellite to which one antenna in a fixed microwave link has partial view. A computer model was developed that constitutes a useful tool in describing; simulating and analyzing an ATPC loop in a single FWS link. With the aid of this model, results are presented on the sensitivity of an ATPC loop in a FWS link with respect to channel conditions, non-ATPC interference and parameter settings.
The Deterministic Sum Capacity of a Multiple Access Channel Interfering with a Point to Point Link (2011)

In this paper, we use the linear deterministic approximation model to study a two user multiple access channel mutually interfering with a point to point link, which represents a basic setup of a cellular system. We derive outer bounds on the achievable sum rate and construct coding schemes achieving the outer bounds. For a large parameter range, the sum capacity is identical to the sum capacity of the interference channel obtained by silencing the weaker user in the multiple access channel. For other interference configurations, the sum rate can be increased using interference alignment, which exploits the channel gain difference of the users in the multiple access channel. From these results, lower bounds on the generalized degrees of freedom for the Gaussian counterpart are derived.
<scp>d</scp> -Amino Acids Trigger Biofilm Disassembly (2010)

Bacteria form communities known as biofilms, which disassemble over time. In our studies outlined here, we found that, before biofilm disassembly, Bacillus subtilis produced a factor that prevented biofilm formation and could break down existing biofilms. The factor was shown to be a mixture of D-leucine, D-methionine, D-tyrosine, and D-tryptophan that could act at nanomolar concentrations. D-amino acid treatment caused the release of amyloid fibers that linked cells in the biofilm together. Mutants able to form biofilms in the presence of D-amino acids contained alterations in a protein (YqxM) required for the formation and anchoring of the fibers to the cell. D-amino acids also prevented biofilm formation by Staphylococcus aureus and Pseudomonas aeruginosa. D-amino acids are produced by many bacteria and, thus, may be a widespread signal for biofilm disassembly.
Low-rate identification of memory polynomials (2014)

We propose a new approach for the low-rate identification of memory polynomials (MPs), which are frequently used to model RF power amplifiers (PAs). Based on ideas from the finite rate of innovation framework, we find the coefficients of the MP in the frequency domain, which requires a relatively small number of measurements (samples), commensurate with the degrees of freedom in the model. By choosing a random set of frequency components, the stability of the identification is ensured. We show that the method can be used directly for special input signals, such as one used for orthogonal frequency division multiplexing, and extend the idea for arbitrary inputs. Experiments using measured data from a class-AB PA demonstrate the effectiveness of the approach. The sampling rate for identifying this PA is reduced by a factor of 1024 (from 107.52MHz to 105 kHz).