gebhart/patrepeval huggingface dataset:
Androgen regulated immunosuppression in prostate cancer through arginase expression (2008)

5150 Background: The significant immunological boost following androgen depletion therapy (ADT) illustrates the immunosuppressive potential of androgens in prostate cancer. As the expression of arginase II (ArgII) appears to be one possible mode of immunosuppression in prostate cancer, it is of interest to determine whether the expression of ArgII in prostate cancer cells is regulated by androgens. Our objectives are to evaluate the in vitro and in vivo expression of ArgII in prostate cancer cell lines and primary tumors. Methods: The androgen-regulated expression of ArgII was evaluated in vivo on a tissue micro-array containing cores from a cohort of 40 control patients (radical prostatectomy only) and 36 ADTx patients (ADT prior to radical prostatectomy). Two independent observers evaluated data from the immunohistochemistry staining against ArgII. The in vitro expression was evaluated in LNCaP cells stimulated for 72 hours with 10nM of R1881. PBMCs from healthy donors were stimulated by 0.250ng/ml of OKT3 in the presence of conditioned media from LNCaP expressing a siRNA against ArgII. PBMCs activation was monitored by ELISA against IFNγ. Results: By immunohistochemistry, in vivo expression of ArgII in ADTx patients was 2x lower in normal adjacent tissues (p6x more ArgII than control LNCaP (p2.5x in the presence of R1881. These results suggest that the presence of androgens favors the expression of ArgII both in vitro and in vivo. PBMCs activated by OTK3 for 24 hours in the presence of conditioned media of LNCaP + SiArgII demonstrated that the absence of ArgII was associated with increased IFNγ secretion: 1,681pg/ml with LNCaP + SiCtrl vs 537pg/ml with LNCaP + SiArgII (p<0.05, Mann-U, n=4). Conclusions: Our results demonstrate that the pro-inflammatory boost following ADT is associated with a lower expression of ArgII. Moreover, our in vitro data suggest an androgen regulation of ArgII expression. Finally, conditioned media from LNCaP transfected with a siRNA against ArgII had improved immunostimulatory potential leading to an increased activation of PBMCs. Our data supports the notion that, in the presence of androgens, prostate cancer cells are directly involved in the development of an immunosuppressive tumor environment through the up-regulation of ArgII. No significant financial relationships to disclose.
193: Outcomes of Delayed Hypospadias Repair: Implications for Decision-Making (2004)

You have accessJournal of UrologyDiscussed Poster, Saturday, May 8, 2004, 1:00 - 5:00 pm1 Apr 2004193: Outcomes of Delayed Hypospadias Repair: Implications for Decision-Making Jennifer L. Dodson, Andrew D. Baird, Linda A. Baker, Steven G. Docimo, John P. Gearhart, and Ranjiv I. Mathews Jennifer L. DodsonJennifer L. Dodson More articles by this author , Andrew D. BairdAndrew D. Baird More articles by this author , Linda A. BakerLinda A. Baker More articles by this author , Steven G. DocimoSteven G. Docimo More articles by this author , John P. GearhartJohn P. Gearhart More articles by this author , and Ranjiv I. MathewsRanjiv I. Mathews More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37455-XAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "193: Outcomes of Delayed Hypospadias Repair: Implications for Decision-Making." The Journal of Urology, 171(4S), p. 51 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 51 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Jennifer L. Dodson More articles by this author Andrew D. Baird More articles by this author Linda A. Baker More articles by this author Steven G. Docimo More articles by this author John P. Gearhart More articles by this author Ranjiv I. Mathews More articles by this author Expand All Advertisement PDF downloadLoading ...
P2‐118: Relationship between attention and gait cycle in patients with Alzheimer's disease (2015)

Gait change in the patients with Alzheimer's disease has been generally studied in specific clinical settings, and slower gait, longer stride time, greater variability of stride time and step length have been reported. Gait in daily living circumstance may be different from gait in clinical test because of much attention demanding task in daily living, but so far, there was no gait analysis study in AD in daily living. We evaluated changes in daily living using a portable gait rythmogram. Twenty-six patients with AD and 8 age-matched cognitively healthy controls (HC) were investigated. A portable gait rhythmogram was attached to the waist of the subject, and recorded acceleration signal derived from trunk movement for 24 hours. Gait cycle (stride time) and amplitude of gait (mean acceleration) were calculated from these data. Cognitive function was assessed using mini mental state examination (MMSE) and Wechsler memory scale-revised (WMS-R). Correlation analysis was performed among each gait parameter and each score of cognitive tests (combined raw score was used instead of index score in WMS-R). Mean gait cycle was 1.24±0.09 sec in AD group, 1.21±0.06 sec in HC group, and gait acceleration was 1.86±0.24 m/s2, 2.04±0.3m/s2 in each groups (not significantly different). Gait cycle was moderately correlated with “attention/ concentration (attention)” in WMS-R in AD group (R=0.59). When AD group were divided into two groups by attention score higher than 54.3 (comparable to HC group) or lower, gait cycle of AD patients with higher attention was relatively longer than that of HC (not statistically significant). Gait in AD patients with higher attention tended to have longer gait cycle in daily living than in HC subjects, which was compatible with previous reports about gait analysis in examination room. Gait in AD patients with lower attention was comparable with in HC subjects, possibly indicating those patients were unable to pay enough attention to their circumstances during their walking.
A feasible solution to provide cloud computing over optical networks (2013)

Cloud computing provides a whole new way to store, access, and exchange information, and introduces new service patterns and business opportunities for network providers and enterprises. Due to the expensive intercommunication among data centers, the difficulty of managing diverse backups, and the cost of operating several data centers, cloud resources are mostly limited to centralized architectures. However, achieving low latency and guaranteeing end-to-end performance are two main challenges in today's cloud computing. Meanwhile, PON-based broadband access networks have been widely considered as one of the most promising solutions for the future telecom access platform that supports residential, enterprise, and mobile backhaul services. The latest research has achieved terabit symmetric capacity that can support up to 800 ONUs at gigabit rates. Therefore, deploying cloud services based on PON access networks provides flexibility in moving services closer to customers so as to ensure low latency and guarantee quality of experience for customers. In this article, we propose, by incorporating PON OLT and ONU physical resources, an infrastructure as a service architecture that enables the delivery of cloud services to end users over PON access networks.
Study on Correction and Tolerance of Phase Fluctuation in a Radio Evaluation System with Under-sampling (2021)

This paper describes the results measured with a radio evaluation system using under-sampling when the frequency difference between carrier and local signals changes continuously. In addition, we show the correction performance by estimating the frequency difference before and after correction. As a result, the phase fluctuation within the correction range could be corrected. Meanwhile, it was clarified that the element of the fluctuating frequency difference affects the signal evaluation and that there is a residual frequency difference after correction.
Recent Developments in Transition Metal-Catalyzed Polymerization I. Synthesis of Helical Substituted Polyacetylenes Using a Rhodium Complex Catalyst-Color Control through Columnar Formation. (2002)

ヘテロ原子を側鎖に含む置換アセチレンは, 水, アルコール, アミン溶媒の存在下, ロジウム (Rh) 錯体触媒によって立体規則的に重合でき, 選択的にシス体の置換ポリアセチレンが高収率で生成する. また, 生成したポリアセチレンの主鎖は, ラセン構造を有し, それが非晶の場合とラセンのポリマーが集合したカラムナーを形成する場合がある. 後者のカラムナーポリマーは, 非晶の場合と比べ著しく長波長側に吸収を示した. カラムナーのシス体を減圧下, 加圧するとトランス体になるが, その吸収極大は, 非晶のそれに比較すると青色シフトしていた. このように, Rh錯体を用いるとラセンの共役ポリマーが生成し, その集合体の量が, 生成したポリマーの吸収波長と関係していることを新しく見いだした.
Heart Failure Research: Translating Basic Science Into Therapies (2009)

Congestive heart failure is a syndrome characterized by decreased cardiac output with consequent neurohormonal activation leading to water and salt retention. This ultimately results in pulmonary and vascular congestion with eventual organ hypoperfusion and death. Often described as a "vicious cycle", congestive heart failure is responsible for more than 40,000 deaths per year in the United States and plays a substantial role in another 250,000 deaths; it takes a financial toll as well, with approximately $34 billion spent each year on the medical care of patients. The key to ending this vicious cycle is applied research. The Department of Cardiology within The Methodist Hospital is conducting research aimed at understanding heart failure and working towards therapies to improve patient care.
An error concealment algorithm for streaming video (2004)

A known problem in video streaming is that loss of a packet usually results into loss of a whole video frame. In this paper we propose an error concealment algorithm specifically designed to handle this sort of losses. The technique exploits information in a few past frames (namely the motion vectors) in order to estimate the forward motion vectors of the last received frame. This information is used to project the last frame onto an estimate of the missing frame. The algorithm has been tested on MPEG-2 video, providing very satisfactory results, and outperforming by several dBs in PSNR the concealment technique based on repetition of the last received frame.
Data from The Interplay Between Neutrophils and CD8&lt;sup&gt;+&lt;/sup&gt; T Cells Improves Survival in Human Colorectal Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Tumor infiltration by different T lymphocyte subsets is known to be associated with favorable prognosis in colorectal cancer. Still debated is the role of innate immune system. We investigated clinical relevance, phenotypes, and functional features of colorectal cancer–infiltrating CD66b&lt;sup&gt;+&lt;/sup&gt; neutrophils and their crosstalk with CD8&lt;sup&gt;+&lt;/sup&gt; T cells.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; CD66b&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; cell infiltration was analyzed by IHC on a tissue microarray including &gt;650 evaluable colorectal cancer samples. Phenotypic profiles of tissue-infiltrating and peripheral blood CD66b&lt;sup&gt;+&lt;/sup&gt; cells were evaluated by flow cytometry. CD66b&lt;sup&gt;+&lt;/sup&gt;/CD8&lt;sup&gt;+&lt;/sup&gt; cells crosstalk was investigated by &lt;i&gt;in vitro&lt;/i&gt; experiments.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; CD66b&lt;sup&gt;+&lt;/sup&gt; cell infiltration in colorectal cancer is significantly associated with increased survival. Interestingly, neutrophils frequently colocalize with CD8&lt;sup&gt;+&lt;/sup&gt; T cells in colorectal cancer. Functional studies indicate that although neutrophils are devoid of direct antitumor potential, coculture with peripheral blood or tumor-associated neutrophils (TAN) enhances CD8&lt;sup&gt;+&lt;/sup&gt; T-cell activation, proliferation, and cytokine release induced by suboptimal concentrations of anti-CD3 mAb. Moreover, under optimal activation conditions, CD8&lt;sup&gt;+&lt;/sup&gt; cell stimulation in the presence of CD66b&lt;sup&gt;+&lt;/sup&gt; cells results in increasing numbers of cells expressing CD45RO/CD62L “central memory” phenotype. Importantly, combined tumor infiltration by CD66b&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T lymphocytes is associated with significantly better prognosis, as compared with CD8&lt;sup&gt;+&lt;/sup&gt; T-cell infiltration alone.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Neutrophils enhance the responsiveness of CD8&lt;sup&gt;+&lt;/sup&gt; T cells to T-cell receptor triggering. Accordingly, infiltration by neutrophils enhances the prognostic significance of colorectal cancer infiltration by CD8&lt;sup&gt;+&lt;/sup&gt; T cells, suggesting that they might effectively promote antitumor immunity. &lt;i&gt;Clin Cancer Res; 23(14); 3847–58. ©2017 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Deep Face Recognition: A Survey (2018)

Face recognition made tremendous leaps in the last five years with a myriad of systems proposing novel techniques substantially backed by deep convolutional neural networks (DCNN). Although face recognition performance sky-rocketed using deep-learning in classic datasets like LFW, leading to the belief that this technique reached human performance, it still remains an open problem in unconstrained environments as demonstrated by the newly released IJB datasets. This survey aims to summarize the main advances in deep face recognition and, more in general, in learning face representations for verification and identification. The survey provides a clear, structured presentation of the principal, state-of-the-art (SOTA) face recognition techniques appearing within the past five years in top computer vision venues. The survey is broken down into multiple parts that follow a standard face recognition pipeline: (a) how SOTA systems are trained and which public data sets have they used; (b) face preprocessing part (detection, alignment, etc.); (c) architecture and loss functions used for transfer learning (d) face recognition for verification and identification. The survey concludes with an overview of the SOTA results at a glance along with some open issues currently overlooked by the community.
Factors Influencing Corn (<i>Zea mays</i>) Tolerance to Trifluralin (1987)

Corn ( Zea mays L.) can be injured by carry-over of trifluralin [2,6-dinitro- N,N -dipropyl-4-(trifluoromethyl) benzenamine] in the soil from one crop year to the next. Factors influencing corn tolerance to carry-over concentrations of trifluralin in the soil were studied in controlled-environment chambers and greenhouse experiments. For several hybrids, greater injury occurred at low than at high temperatures. This injury was especially evident for ‘Pioneer 3320’ and ‘Pioneer 3572’ when the soil moisture was at 100% field capacity. Addition of phosphorus fertilizer appeared to have no influence upon trifluralin injury but did interact with alachlor [2-chloro- N -(2,6-diethylphenyl)- N -(methoxymethyl)acetamide]. Alachlor plus trifluralin injured corn in an apparently additive manner. Significant differences were found in genetic tolerance of corn to trifluralin within a group of hybrids. Tolerance of specific hybrids to trifluralin was altered by environmental conditions.
Readability of American Online Patient Education Materials in Urologic Oncology: A Need for Simple Communication (2021)

To determine readability levels of reputable cancer and urologic websites addressing bladder, prostate, kidney and testicular cancers.
Catquest questionnaire: re‐validation in an Australian cataract population (2009)

The Catquest-9SF is a reliable and valid measure of visual disability in the Australian cataract population.
Finite element code (FEB3) and dependencies (2016)

"FEB3.tar.gz" contains the sources code of the finite element methodology used to simulate Oncoplastic Breast Surgery. The compressed folder contains a "README.md" that outlines the steps required in order to compile the above libraries (blitz, GSL, etc.).<br><br><br>
Design and testing of an instrumentation system to reduce stimulus pulse amplitude requirements during FES (2008)

Functional Electrical Stimulation (FES) has been used for decades to restore muscle function following neural trauma. Another promising use has been to maintain or increase muscle strength following injury. Unfortunately in the latter case there is considerable stimulation pain for the sensorially intact subject during effective levels of stimulation using surface electrodes. Recent research [1][2] has suggested using a constant long (up to 10 ms) low amplitude or ramped conditioning pulse just prior to the high amplitude stimulus pulse (100 - 200 microsec) to reduce the excitably of sensory nerve fibers. However, commercial muscle stimulators cannot be easily modified to provide such complex pulse patterns and flexible pulse train control. We have designed and implemented a novel, very flexible LabVIEW based monophasic constant current muscle stimulator that provides pulse trains with long duration prepulses and high voltage stimulus pulses with selectable shapes, amplitudes, durations and frequencies. As well, the stimulator system includes an isolated EMG amplifier to record the evoked M-waves, which are used to estimate the fraction of muscle motor units being stimulated. We are presently testing this system, by stimulating the median nerve of human subjects and measuring the evoked M-waves for a range of stimulus pulse amplitudes, preceded by either ramped or rectangular low amplitude prepulses. The results indicate that, rather than inhibiting the activation of motor axons, as has been suggested [4], the prepulses at very low amplitudes excite these axons to subthreshold levels. The amplitudes of the stimulus pulses can then be significantly reduced while still achieving high levels of muscle activation.
Real-Time People Counting System for Customer Movement Analysis (2018)

We propose a real-time people-counting system that can be applied in a retail store to estimate the number of people entering and exiting. The proposed method consists of three main procedures: foreground extraction based on the average picture level (APL), a dilated motion search based on the maximum a posteriori probability (MAP), and flow analysis based on multiple touching sections (MTS). We first produce a background model to extract the foreground by using line-wise APL. A dilated motion search with the MAP-based approach is then used to estimate the motions on the line of interest. Next, the flow generated by the foreground on the MTS is analyzed. Finally, the results of the motion estimation and flow analysis are incorporated to produce the number of people entering and exiting the store. We used a low-cost microcomputer to implement the system, which is capable of wireless transmission and is easy to install in a retail environment. Experimental results show that the proposed method provided the best F1 score and accuracy values for the people count results with much lower computational complexity than benchmark methods. In addition, it successfully estimated the number of people entering and exiting the store in real time.
Buffering global interconnects in structured ASIC design (2005)

Structured ASICs present an attractive alternative to reducing design costs and turn around times in nanometer designs. As with conventional ASICs, such designs require global wires to be buffered. However, via-programmable designs must prefabricate and preplace buffers in the layout. This paper proposes a novel and accurate statistical estimation technique distributing prefabricated buffers through a layout. It employs Rent's rule to estimate the buffer distribution required for the layout, so that an appropriate structured ASIC may be selected for the design. Experimental results show that the estimation for a uniform buffer distribution is accurate and economic.
A 90GHz-carrier 30GHz-bandwidth hybrid switching transmitter with integrated antenna (2010)

There is considerable interest in wideband pulse modulation at mm-Wave frequencies for application in radar and medical imaging systems [1,2]. Accuracy and resolution in these respective systems are determined by the minimum pulse width (PW). PWs down to 300ps have previously been reported for 24/79GHz carrier frequencies [1,3]. This paper presents the design of the first pulse-based transmitter with integrated antenna to achieve sub-100ps PWs at mm-Wave frequencies in silicon. The transmitter generates variable measured PWs in the range of 35 to 376ps. To obtain this performance, hybrid PA/antenna switching has been explored in combination with high-speed digital switching circuitry.
Observation of cone and rod photoreceptors in normal subjects and patients using a new generation adaptive optics scanning laser ophthalmoscope (2011)

We demonstrate the capability of a new generation adaptive optics scanning laser ophthalmoscope (AOSLO) to resolve cones and rods in normal subjects, and confirm our findings by comparing cone and rod spacing with published histology measurements. Cone and rod spacing measurements are also performed on AOSLO images from two different diseased eyes, one affected by achromatopsia and the other by acute zonal occult outer retinopathy (AZOOR). The potential of AOSLO technology in the study of these and other retinal diseases is illustrated.
ADCK4 mutations promote steroid-resistant nephrotic syndrome through CoQ10 biosynthesis disruption (2013)

Identification of single-gene causes of steroid-resistant nephrotic syndrome (SRNS) has furthered the understanding of the pathogenesis of this disease. Here, using a combination of homozygosity mapping and whole human exome resequencing, we identified mutations in the aarF domain containing kinase 4 (ADCK4) gene in 15 individuals with SRNS from 8 unrelated families. ADCK4 was highly similar to ADCK3, which has been shown to participate in coenzyme Q10 (CoQ10) biosynthesis. Mutations in ADCK4 resulted in reduced CoQ10 levels and reduced mitochondrial respiratory enzyme activity in cells isolated from individuals with SRNS and transformed lymphoblasts. Knockdown of adck4 in zebrafish and Drosophila recapitulated nephrotic syndrome-associated phenotypes. Furthermore, ADCK4 was expressed in glomerular podocytes and partially localized to podocyte mitochondria and foot processes in rat kidneys and cultured human podocytes. In human podocytes, ADCK4 interacted with members of the CoQ10 biosynthesis pathway, including COQ6, which has been linked with SRNS and COQ7. Knockdown of ADCK4 in podocytes resulted in decreased migration, which was reversed by CoQ10 addition. Interestingly, a patient with SRNS with a homozygous ADCK4 frameshift mutation had partial remission following CoQ10 treatment. These data indicate that individuals with SRNS with mutations in ADCK4 or other genes that participate in CoQ10 biosynthesis may be treatable with CoQ10.
Batteries for electric road vehicles (2017)

The dependence of modern society on the energy stored in a fossil fuel is not sustainable. An immediate challenge is to eliminate the polluting gases emitted from the roads of the world by replacing road vehicles powered by the internal combustion engine with those powered by rechargeable batteries. These batteries must be safe and competitive in cost, performance, driving range between charges, and convenience. The competitive performance of an electric car has been demonstrated, but the cost of fabrication, management to ensure safety, and a short cycle life have prevented large-scale penetration of the all-electric road vehicle into the market. Low-cost, safe all-solid-state cells from which dendrite-free alkali-metal anodes can be plated are now available; they have an operating temperature range from -20 °C to 80 °C and they permit the design of novel high-capacity, high-voltage cathodes providing fast charge/discharge rates. Scale-up to large multicell batteries is feasible.