gebhart/patrepeval huggingface dataset:
Modeling of thermal effects in antivascular ultrasound therapy (2012)

Antivascular ultrasound consisting of low-intensity sonication in the presence of circulating microbubbles of an ultrasound contrast agent has been demonstrated to disrupt blood flow in solid cancers. In this study a mathematical framework is described for the microbubble-induced heating that occurs during antivascular ultrasound. Biological tissues are modeled as a continuum of microbubble-filled vasculature, cells, and interstitial fluids with compressibility equal to the sum of the compressibility of each component. The mathematical simulations show that the absorption of ultrasound waves by viscous damping of the microbubble oscillations induced significant local heating of the tissue vasculature. The extent and the rate of temperature increase not only depends on the properties of the microbubbles and the sonication parameters but is also influenced markedly by the blood flow. Slow flow conditions lead to higher tissue temperatures due to a stronger interaction between microbubbles and ultrasound and reduced heat dissipation. Because tumors have slower blood flow than healthy tissue, the microbubble-induced ultrasound antivascular therapy is likely to affect cancerous tissue more extensively than healthy tissue, providing a way to selectively target the vasculature of cancers.
Developmentally regulated expression of the wound‐ and pathogen‐responsive tomato anionic peroxidase in green fruits (1993)

Summary A highly anionic peroxidase (TAP) isolated from tomato was thought to be induced only upon wounding or fungal attack as this protein and its mRNA could not be detected in the vegetative tissues of healthy tomato but accumulated to very high levels in tissues responding to wounding or fungal attack. We now demonstrate a pattern of developmentally regulated expression of the tap gene in the exocarp of green, but not red, tomato fruits. Detaching green fruits from the vine, however, leads to the complete loss of the tap transcript within 72 h. Administration of various growth regulators through the pedicel of detached green fruits revealed that cytokinin was able to sustain a level of tap transcripts in 72 h detached fruits comparable with that found in fruits attached to the vine. Wound‐induced expression of tap was confined to the healing periderm of green fruits but was not detectable in the wound‐tissue of post‐climacteric ripening fruits. These results suggest that the developmental and wound regulated expression of tap may occur by separate or overlapping signal transduction pathways. Treatment of tomato plants and green fruits with 2‐chloro‐ethylphosphonic acid (ethephon) demonstrated that ethylene does not effect the developmental suppression of tap in post‐climacteric fruits, nor does it alter the normal levels of tap transcripts in either healthy or wound‐healing tomato tissues.
DIAGNOSIS OF BACTERIAL VAGINOSIS IN A RURAL SETUP : COMPARISON OF CLINICAL ALGORITHM, SMEAR SCORING AND CULTURE BY SEMIQUANTITATIVE TECHNIQUE (2004)

This study was undertaken to estimate the prevalence of bacterial vaginosis (BV) and other sexually transmitted infections (STIs) in a rural set up and compare the smear scoring system to that of culture by semiquantitative technique. A total of 505 married women, who were in sexually active age group of 15-44 years, were selected from three different villages. High vaginal swabs, endocervical swabs, vaginal discharge and blood were collected and processed in the laboratory. Overall prevalence of 29% reproductive tract infection was detected. Endogenous infection was commonly observed (27.92%), and very low prevalence of STIs (Trichomonas 1.18%, Syphilis 0%, Gonorrhea 0%) was detected. Diagnosis of BV was possible in 104 (20.5%) women by smear alone and 88 (17.42%) women by semiquantitative culture.
Author Correction: Simulation of visual acuity by personalizable neuro-physiological model of the human eye (2019)

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Sinus bradycardia is associated with poor outcome in critically ill patients with COVID-19 due to the B.1.1.7 Lineage (2021)

The progress of COVID-19 from moderate to severe may be precipitous, while the characteristics of the disease are heterogenous. The aim of this study was to describe the development of sinus bradycardia in critically ill patients with COVID-19 and its association with outcome in outbreak due to the SARS-CoV-2 B.1.1.7 Lineage. We leveraged the multi-center SuPAR in Adult Patients With COVID-19 (SPARCOL) study and identified patients who required admission to intensive care unit (ICU). Inclusion criteria were: (a) adult (≥18 years old) patients hospitalized primarily for COVID-19; (b) a confirmed SARS-CoV-2 infection diagnosed through reverse transcriptase polymerase chain reaction test of nasopharyngeal or oropharyngeal samples; and (c) at least one blood sample collected at admission and stored for suPAR, hs-CRP, and ferritin testing. All patients had continuous heart rate monitoring during hospitalization. In total, 81 patients were included. Of them, 17 (21 %) and 64 (79 %) were intubated and admitted to the ICU during the first and second wave, respectively. Two (12 %) and 62 (97 %) developed bradycardia before ICU admission, respectively (p < 0.001). Patients with bradycardia had increased suPAR (p < 0.001) and hs-CRP level (p < 0.001). Infusion of isoprenaline and/or noradrenaline was necessary to maintain an adequate rate and peripheral perfusion in all patients. Mortality was significantly higher in patients with bradycardia (p < 0.001). In conclusion, bradycardia was associated with poor outcome. As B.1.1.7 variant strain is spreading more rapidly in many countries, our findings help in the identification of patients who may require early admission to ICU.
Mapping sample scenarios to operational models (2016)

Achieving mission objectives in complex and increasingly adversarial networks is difficult even under the best of circumstances. Currently, there are few tools for reasoning about how to react to rapid changes in a given network's environmental state; that is, we do not know how to cope with adversarial actions in hostile environments. In this paper, we consider a preliminary operational model that combines the states, detection outputs, and agility maneuvers associated with a cyber-operation in hostile networks. The goal is positing the development of an operational model to aid in the successful completion of mission objectives with a minimal maneuver cost. We present a host remediation case study that explores the efficacy of the proposed model in aiding operation completion.
Analog computing in the Soviet Union: an interview with Boris Kogan (2005)

This paper includes an interview with Yakovlevich Kogan, a professor at the Computer Science Dept. of the University of California, Los Angeles. Prof. Kogan has had a fascinating career in the most formative years of the control field. His pioneering work on simulating complex systems, including the development of the Soviet Union's first analog computers and hybrid computers, was critical to the control work being done then. This paper includes Prof. Kogan's views on the first Soviet analog computer, his life and work in the Soviet Union, his contemporaries, his emigration to the US, and his current undertakings.
LDL cholesterol and uridine levels in blood are potential nutritional biomarkers for clinical progression in Alzheimer's disease: The NUDAD project (2020)

Our findings suggest that LDL cholesterol and uridine play a-stage-dependent-role in the clinical progression of AD.
PS-BPB09-2: DEVELOPMENT OF LONG-ACTING HUMAN ADRENOMEDULLIN FC FUSION PROTEINS (2023)

Background: Human adrenomedullin (hAM) is a hypotensive peptide hormone with strong anti-inflammatory effects. AM consists of 52 amino acid residues with an amidated C-terminus and a ring structure formed by intramolecular disulfide bonds. Both of these structures are necessary for binding to receptors and to exert their biological functions. AM has also shown therapeutic effects in various animal disease models, including inflammatory bowel disease, ischemic heart disease, sepsis and stroke. However, the short half-life of native AM in the blood required continuous administration for treatment. To solve this, we have developed four human IgG1 and IgG4 Fc fusion proteins containing full-length human AM or AM(6–52). Methods: Recombinant Fc-AM derivatives were generated using mammalian cells. After that, we tested the biological activities of Fc-fusion AMs (Fc-AMs) to stimulate the intracellular accumulation of cAMP in HEK-293 cells stably expressing the AM1 receptor. Next, we compared IgG1-AM (6–52) and IgG4-AM (6–52) concentrations in the peripheral blood and tissues of rats after subcutaneous injection. In addition, the antihypertensive effect of Fc-AM was examined on spontaneously hypertensive rats (SHRs) which were given high salt diets. Results: We have developed four Fc-AMs, which are long-acting AM derivatives in mammalian cells. Fc-AMs produced in mammalian cells do not require refolding or amidation. Indeed, Fc-AMs could be measured by mAM assay, which recognizes the amidated form, indicating that Fc-AMs produced in mammalian cells were amidated. Fc-AMs, generated in a mammalian cell production system can therefore easily be produced in large amounts with few purification steps. The Fc-AMs stimulated intracellular cAMP production in cultured cells stably expressing the AM type I receptor in vitro. Fc-AM (6–52) induced higher cAMP levels for the receptor than Fc-AM. The pharmacokinetic study was performed using N-terminal deficient AM derivatives, which have strong receptor binding ability. Sufficient concentrations of IgG1-AM (6–52) and IgG4-AM (6–52) were observed in blood 14 days after a single subcutaneous administration. Tissue transfer to the kidney and small intestine was observed after administration of IgG1-AM (6–52) or IgG4-AM (6–52) to rats. In addition, the single subcutaneous administration of IgG4-AM (6–52) suppressed the increase in blood pressure in SHRs which were loaded with high salt diets. Conclusion: Fc-AM produced from mammalian cells is easily prepared and seems to be an effective new therapeutic agent for hypertension.
Outcomes of Transcatheter Aortic Valve Replacement in Transplant Recipients (2020)

BackgroundTranscatheter aortic valve replacement (TAVR) has become the mainstay in the treatment of patients with severe calcific aortic stenosis. However, little is known about the outcomes of TAVR in transplant recipients.MethodsPatients who underwent TAVR and transplant were compared to a control group of TAVR patients who did not have a transplant, between 2014 and 2017. The primary endpoints were all-cause mortality and the onset of prosthetic valve endocarditis. The secondary endpoints were based on the Valve Academic Research Consortium-2 (VARC-2) criteria. Propensity score matching, based on age, race, and gender, was used to compare the outcomes between transplant and non-transplant patients.Results35 patients underwent TAVR as well as organ transplants (26 solid organ and 9 bone marrow). Compared to non-transplant patients (n = 1,366), transplant patients underwent TAVR at a younger age. After matching, transplant patients (n = 34) were more likely to develop prosthetic valve endocarditis compared to non-transplant patients (n = 68) (p = 0.04); however, the majority were on immunosuppressive agents. Transplant patients had a higher 3-year mortality rate, but not 30-day and 1-year mortality (p < 0.001). NYHA after TAVR was also higher in transplant patients (p = 0.04). There was no significant difference in other outcomes based on VARC-2 criteria.ConclusionTransplant patients undergo TAVR at a younger age, yet are at an increased risk of post-TAVR complications. In transplant patients, survival is similar to non-transplant patients at 30 days and 1-year. TAVR is a viable treatment option for patients with organ transplantation and severe symptomatic aortic stenosis.AbbreviationsAR: Aortic Regurgitation; AS: Aortic Stenosis; AVR: Aortic Valve Replacement; CHF: congestive heart failure; IQR: Interquartile Ranges; NYHA: New York Heart Association; PVR: Paravalvular Regurgitation; TAVR: Transcatheter Aortic Valve Replacement; VARC: Valve Academic Research Consortium
Supplementary Table 4 from A Fusion Protein Complex that Combines IL-12, IL-15, and IL-18 Signaling to Induce Memory-Like NK Cells for Cancer Immunotherapy (2023)

&lt;p&gt;Table 4 Excel Document&lt;/p&gt;
A correlation between NMR peak intensities and a fictitious spin 1/2 presentation of the <i>z</i>‐component of nuclear spins <i>I</i> &gt; 1/2 (2013)

In a recent publication, it was suggested that for I &gt; 1/2 the peaks intensities can be interpreted to be the result of spin dynamics along the z axis. The intensity ratios were found to be independent of the magnetic field, suggesting that the important factor determining the peak intensities is the operator I z , and its interaction with the radio frequency magnetic field. In the current comment, we suggest that a presentation of this operator as a superposition of fictitious spins 1/2 provides an alternative explanation for the correlation between the I z operator and the peak intensities. It is further shown that the correlation between the I z operator and the NMR peak intensities is valid only for nonselective excitation or under conditions where Fermi's golden rule applies. The relevance of the spin‐lock experiment for such a correlation is discussed. © 2014 Wiley Periodicals, Inc. Concepts Magn Reson Part A 42A: 182–186, 2013.
Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization (2018)

Therapies targeting immune checkpoints have shown great clinical potential in a subset of patients with cancer but may be hampered by a failure to reverse the immunosuppressive tumor microenvironment (TME). As the most abundant immune cells in TME, tumor-associated macrophages (TAM) play nonredundant roles in restricting antitumor immunity. The leucine-rich repeat-containing G-protein-coupled receptor 4 (Lgr4, also known as Gpr48) has been associated with multiple physiologic and pathologic functions. Lgr4 and its ligands R-spondin 1-4 have been shown to promote the growth and metastasis of tumor cells. However, whether Lgr4 can promote tumor progression by regulating the function of immune cells in the tumor microenvironment remains largely unknown. Here, we demonstrate that Lgr4 promotes macrophage M2 polarization through Rspo/Lgr4/Erk/Stat3 signaling. Notably, urethane-induced lung carcinogenesis, Lewis lung carcinoma (LLC), and B16F10 melanoma tumors were all markedly reduced in Lgr4<sup>fl/fl</sup>Lyz2<sup>cre/+</sup> mice, characterized by fewer protumoral M2 TAMs and increased CD8<sup>+</sup> T lymphocyte infiltration in the TME. Furthermore, LLC tumor growth was greatly depressed when Rspo/Lgr4/Erk/Stat3 signaling was blocked with either the LGR4 extracellular domain or an anti-Rspo1 antibody. Importantly, blocking Rspo-Lgr4 signaling overcame LLC resistance to anti-PD-1 therapy and improved the efficacy of PD-1 immunotherapy against B16F10 melanoma, indicating vital roles of Rspo-Lgr4 in host antitumor immunity and a potential therapeutic target in cancer immunotherapy.<b>Significance:</b> This study identifies a novel receptor as a critical switch in TAM polarization whose inhibition sensitizes checkpoint therapy-resistant lung cancer to anti-PD-1 therapy.<b>Graphical Abstract:</b> http://cancerres.aacrjournals.org/content/canres/78/17/4929/F1.large.jpg <i>Cancer Res; 78(17); 4929-42. ©2018 AACR</i>.
STORM: Scalable Resource Management for Large-Scale Parallel Computers (2006)

Although clusters are a popular form of high-performance computing, they remain more difficult to manage than sequential systems - or even symmetric multiprocessors. In this paper, we identify a small set of primitive mechanisms that are sufficiently general to be used as building blocks to solve a variety of resource-management problems. We then present STORM, a resource-management environment that embodies these mechanisms in a scalable, low-overhead, and efficient implementation. The key innovation behind STORM is a modular software architecture that reduces all resource management functionality to a small number of highly scalable mechanisms. These mechanisms simplify the integration of resource management with low-level network features. As a result of this design, STORM can launch large, parallel applications an order of magnitude faster than the best time reported in the literature and can gang-schedule a parallel application as fast as the node OS can schedule a sequential application. This paper describes the mechanisms and algorithms behind STORM and presents a detailed performance model that shows that STORM's performance can scale to thousands of nodes
Total assignments of the 1H NMR of decanucleotide duplexes containing the recognition sites of restriction enzymes. (1986)

Complementary DNAs, decanucleotides, were synthesized by solid phase synthesis. They contain six base pairs with different sequences in the center, flanked by GC pairs to stabilize the ends of the helix. All the imino and non-exchangeable protons of these decamers in aqueous solution were assigned by NOESY experiment. Sequence dependent exchange rates of imino protons and the chemical shifts of non-exchangeable protons were examined.
&lt;title&gt;Development status of the EOS Multiangle Imaging SpectroRadiometer (MISR)&lt;/title&gt; (1993)

The multi-angle imaging spectroradiometer (MISR) instrument is currently under development for flight on the first earth observing system platform, EOS-AM1, to be launched in 1998. The instrument will obtain global multi-angle imagery at nine separate view angles, using a separate charge-coupled-device pushbroom camera at each angle. Images will be obtained at 443, 555, 670, and 865 nm with spatial sampling, selectable in-flight, ranging from 275 m to 2.2 km. Data from the instrument will be used to retrieve the optical properties of tropospheric aerosols over land and ocean, to study the bidirectional reflectance properties of the Earth's surface and clouds, and to measure terrain topography and cloud heights. This paper reviews the MISR science objectives, presents an update to some of the instrument design parameters, and discusses the status of the instrument design and development. Test results from a recently built `brassboard' prototype camera are discussed.
Sympathetic activity–associated periodic repolarization dynamics predict mortality following myocardial infarction (2014)

This study was funded by Angewandte Klinische Forschung, University of Tübingen (252-1-0).
Theoretical Analyses of the Tautomeric and Conformational Equilibria of Histamine and (.alpha.R,.beta.S)-.alpha.,.beta.-Dimethylhistamine in the Gas Phase and Aqueous Solution. [Erratum to document cited in CA121:9018] (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTheoretical Analyses of the Tautomeric and Conformational Equilibria of Histamine and (.alpha.R,.beta.S)-.alpha.,.beta.-Dimethylhistamine in the Gas Phase and Aqueous Solution. [Erratum to document cited in CA121:9018]Peter I. Nagy, Graham J. Durant, Wayne P. Hoss, and Douglas A. SmithCite this: J. Am. Chem. Soc. 1994, 116, 17, 7957Publication Date (Print):August 1, 1994Publication History Published online1 May 2002Published inissue 1 August 1994https://pubs.acs.org/doi/10.1021/ja00096a088https://doi.org/10.1021/ja00096a088research-articleACS PublicationsRequest reuse permissionsArticle Views39Altmetric-Citations3LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Advanced occupancy grid techniques for lidar based object detection and tracking (2009)

The robust and reliable detection of objects in the surrounding of a vehicle is an important prerequisite for collision avoidance and collision mitigation systems. In this paper, an ego-motion compensated tracking approach is presented which uses extended occupancy grid methods for both detection and tracking of objects observed by lidar. The approach is able to estimate the velocity and direction of moving objects as well as to distinguish between moving and stationary objects. Additionally, an approach for drastically reducing the computational effort is presented.
Okadaic Acid Exerts a Full Insulin-like Effect on Glucose Transport and Glucose Transporter 4 Translocation in Human Adipocytes (1996)

The effects of the serine/threonine phosphatase inhibitor, okadaic acid, and insulin on glucose transport activity, glucose transporter 4 translocation to the plasma membrane, and the signaling pathway of insulin were examined in human adipocytes. Okadaic acid consistently produced a greater increase than insulin in the rate of glucose transport, and both agents together had a partial additive effect. Both insulin alone and okadaic acid alone stimulated the translocation of glucose transporter 4 to the plasma membrane. Insulin, but not okadaic acid, stimulated phosphatidylinositol 3-kinase (PI 3-kinase) activity, and wortmannin completely inhibited the effect of insulin on glucose transport. When the cells were incubated with both agents, okadaic acid inhibited insulin-stimulated PI 3-kinase activity but did not block the association of the p85 or p110 subunits of PI 3-kinase with insulin receptor substrate 1. Insulin-stimulated tyrosine phosphorylation of insulin receptor substrate 1 was only slightly reduced (15-30%) by okadaic acid. These data demonstrate that okadaic acid exerts a full insulin-like effect independent of the activation of PI 3-kinase. Thus, PI 3-kinase lipid kinase is not essential for glucose transporter 4 translocation in human adipocytes, and different pathways exist that lead to glucose transporter 4 translocation and increased glucose transport.
Structure elucidation of the core regions from Citrobacter O4 and O36 lipopolysaccharides by chemical and enzymic methods, gas chromatography/mass spectrometry, and NMR spectroscopy at 500 MHz (1988)

Novel enterobacterial core oligosaccharides were isolated from Citrobacter O4 and O36 lipopolysaccharides, and their structures were determined by methylation analysis, Smith degradation and enzymatic degradations, gas chromatography/mass spectrometry, and two-dimensional phase-sensitive correlated, relayed coherence transfer, double-quantum, triple-quantum-filtered, and nuclear Overhauser effect (NOE) 1H NMR spectroscopy at 500 MHz. In the formulas, all hexose residues are D-hexopyranoses, and heptoses are L-glycero-D-manno-heptopyranoses; the alternative locations of the side-chain heptose and pyrophosphorylethanolamine (PPEtN) residues are marked by dashed lines; dOclA stands for 3-deoxy-D-manno-octulosonic acid. (formula; see text) Along with these complete cores, incomplete ones, lacking the hexosamine trisaccharides, occur in the lipopolysaccharides of both types. Qualitative NOE data were in good agreement with the minimum energy conformation of the above O36 oligosaccharide, calculated with the aid of the SUGAR program [Sundin, A., Carter, R. E., & Liljefors, T. (1988) J. Mol. Graphics (in press)].