gebhart/patrepeval huggingface dataset:
VOLTTRON-enabled Home Energy Management System (2019)

Home Energy Management Systems (HEMS) consist of software and hardware systems that provide communication, control, and management among different electronic devices, such as heating, ventilation, and air-conditioning (HVAC) systems. HEMS are a growing market sector in the era of smart grids and smart homes. HEMS can help both homeowners and utilities save money and energy by monitoring and controlling smart devices in a house. Based on the Department of Energy (DOE) Building Energy Data Book, 41% of the energy consumed in the United States is used by buildings (see Figure 1). This shows the importance of saving energy in the building sector. This report introduces two approaches that existing HEMS vendors can use to leverage VOLTTRON as their control and interoperability engine. The goal of this project is to make open-source, user-friendly HEMS available to the market so that everyone can benefit from them. The HEMS introduced as a result of this study should satisfy HEMS specifications such as device monitoring and control, seamless communication between devices, DR, intelligence, data management, and security.
Abstract 187: Autophagy in the Myocardium of Mice Subjected to Ischemia Followed by Reperfusion (2010)

Introduction: Autophagy has been thought by many to be cardioprotective, but its extent early after myocardial ischemic insults remains unclear. We characterized the magnitude of early autophagy in...
Pharmacological and Pre-Clinical Testing of 5-NIdR as a New Therapeutic Agent Against Brain Cancer (2014)

Approximately 4,000 children in the United States are diagnosed annually with a brain tumor. Brain cancers are the deadliest of all pediatric cancers as they have survival rates of less than 20%. Although surgery and radiation therapy are widely used to treat adult patients, chemotherapy is the primary therapeutic option for children. One important chemotherapeutic agent is temozolomide, an alkylating agent that causes cell death by damaging DNA. In this project, we tested the ability of a specific non-natural nucleoside developed in our lab, designated 5-NIdR, to increase the efficacy of temozolomide against brain cancer. Cell-based studies demonstrate that the combination of 5-NIdR and temozolomide kills more cells compared to treatment with either temozolomide or 5-NIdR used alone. Microscopy techniques demonstrate that the combination of 5-NIdR and temozolomide causes cell death via apoptosis rather than necrosis. Animal studies using xenograft (nude) mice were performed to evaluate the in vivo efficacy and safety of this drug combination against brain cancer. Preliminary results are provided which indicate that treatment with 5-NIdR does not inhibit the rate of tumor growth. In contrast, treatment with temozolomide reduces the rate of tumor growth but does not lead to the complete elimination of the tumor. Striking results are obtained using 5-NIdR and temozolomide together as this drug combination causes a significant reduction in tumor size. Finally, mice treated with the combination of 5-NIdR and temozolomide do not show overt signs of side effects such as weight loss, dehydration, or fatigue. Collectively, these studies provide pharmacological evidence for combining 5-NIdR and temozolomide as a new treatment strategy to effectively treat brain cancers.
SLIF: a specification-level intermediate format for system design (2002)

As methodologies and tools for chip-level design mature, design effort becomes focused on higher abstraction levels. Presently, much effort is focused on system-level design, where the key tasks include system component allocation, functional partitioning and transformation, and coarse estimation. However, commonly-used internal formats of functionality, such as the control-dataflow graph, are too fine-grained for the system level. We introduce a more abstract format, and we demonstrate its order-of-magnitude more efficient support of system design tasks and its support of practical designer interaction. The format is used by the SpecSyn system design environment, and can be extended to handle many new system design problems.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
A New Hybrid Air Blast Nozzle for Advanced Gas Turbine Combustors (2000)

The push towards higher specific fuel consumption and smaller, lighter packaging for aerospace gas turbine engines has resulted in large increases in engine operating pressure and temperature. This is a trend that is expected to continue, and as a result, thermal management of the hot engine section including the fuel nozzle, combustor, and turbine has emerged as a critical technology area requiring further development. For the fuel injection system, nozzle thermal management, turndown ratio, and atomization performance while maintaining correct combustor aerodynamics are the most important performance features that necessitate optimization. Significant advances in fuel injection concepts are required to meet the increasingly demanding combustor requirements. Complex heat-shielded designs are often required to reduce nozzle wetted-wall temperatures and prevent the formation of carbonaceous deposits within the fuel delivery passages. To support the development of advanced combustors and address these increasing performance demands, Parker has developed a new Hybrid Air Blast nozzle. Advanced analytical and experimental design tools were applied to reduce the cut-and-try approach previously used in nozzle development. The developed hybrid air blast design achieved excellent atomization performance over a wide range of fuel flow rates and air pressure drops. Thermal analysis of the nozzle showed that the wetted wall temperatures were reduced considerably when compared to previous designs operating at the same conditions. Eight-port circumferential spray patternation results were outstanding with the patternation factor at various values of liquid flow rate ranging between 0.12 and 0.18. This patternation factor is a significant improvement over those of current state-of-the-art injectors that are typically of the order of 0.25.
Responsiveness to IL-2 characterizes a stable Foxp3+ subset in mice (148.16) (2011)

Abstract It has recently been suggested that lymphopenic conditions result in the loss of Foxp3 expression in CD4+ regulatory T (Treg) cells, thereby switching their function from suppressors to autoimmune effectors. To assess the factors that influence stable Foxp3 expression, we followed the fate of highly purified populations of Foxp3hi cells obtained by serial flow cytometric sorting from Foxp3gfp mice. Consistent with previous reports, we observed that a substantial frequency of Foxp3- cells could be generated from 10^4 Foxp3hi cells after transfer into lymphopenic hosts. This frequency was reduced to approximately 2% in the presence of 10^5 co-injected CD4+ filler cells. However, Foxp3hi cells deficient in IL-2 signaling, or cells expressing intermediate levels of Foxp3 (Foxp3int) were much less stable. In fact, Foxp3int cells that fail to upregulate Foxp3 upon in vitro IL-2 stimulation were the least stable. These data therefore suggest that IL-2 and Foxp3 are part of a positive feedback loop that maintains Treg cell lineage stability. Furthermore, it appears that the minimal level of instability in Foxp3hi Treg cells is unlikely to substantially contribute to spontaneous autoimmunity under clinically relevant lymphopenic states such as bone marrow transplantation.
Abstract 20753: Cardiosphere-Derived Cell Exosomes Enhance Macrophage Efferocytosis to Reduce Infarct Size Following Ischemia/Reperfusion Injury (2017)

Introduction: Cardiosphere-derived cells (CDCs) and CDC exosomes (CDCexo) are cardioprotective against ischemia/reperfusion (I/R) injury if delivered within 20-30 mins of reperfusion (Kanazawa et a...
Phase I Trial of Granulocyte--Macrophage Colony-Stimulating Factor Plus High-Dose Cyclophosphamide Given Every 2 Weeks: a Cancer and Leukemia Group B Study (1993)

Phase II studies of this intensive regimen in malignant diseases sensitive to alkylating agents are currently being done in CALGB.
Contract Terms in Favour of Third Parties (2013)

There are two main uses to which the proposed Common European Sales Law (CESL) or Draft Common Frame of Reference (DCFR) may be put. The first is as an optional instrument which, if the parties choose it, would replace the applicable national law on contract. The second main use is as a toolbox which itself can be subdivided into various uses, for example as a source of inspiration for an EU legislator or a domestic legislator or as an interpretation guide by the European or domestic courts. This chapter focuses on the CESL or DCFR as an optional instrument but also offers some brief comments at the end on the CESL or DCFR as a toolbox.
Are the frail destined to fail? Frailty index as predictor of surgical morbidity and mortality in the elderly (2012)

Prognostic study, level II.
Neuropeptide Treatment with Cerebrolysin Enhances the Survival of Grafted Neural Stem Cell in an α-Synuclein Transgenic Model of Parkinson's Disease (2015)

Neuronal stem cell (NSC) grafts have been investigated as a potential neuro-restorative therapy in Parkinson's disease (PD) but their use is compromised by the death of grafted cells. We investigated the use of Cerebrolysin (CBL), a neurotrophic peptide mixture, as an adjunct to NSC therapy in the α-synuclein (α-syn) transgenic (tg) model of PD. In vehicle-treated α-syn tg mice, there was decreased survival of NSCs. In contrast, CBL treatment enhanced the survival of NSCs in α-syn tg groups and ameliorated behavioral deficits. The grafted NSCs showed lower levels of terminal deoxynucleotidyl transferase dUTP nick end labeling positive cells in the CBL-treated mice when compared with vehicle-treated α-syn tg mice. No evidence of tumor growth was detected. Levels of α-syn were similar in the vehicle in CBL-treated tg mice. In conclusion, CBL treatment might be a potential adjuvant for therapeutic NSC grafting in PD.
Terahertz Imaging of Multi-Level Pseudo-Random Reflectance (2018)

This paper introduces a terahertz (THz)-based absolute positioning system with a single THz transceiver as the read head and a multi-level pseudo-random reflectance pattern (e.g., multi-level m-sequences) as the high-resolution scale in a compressed scanning mode. One of key technical challenges here is to computationally recover the multi-level pseudo-random reflectance pattern from compressed measurements. To this end, we develop a variational Bayesian approach to exploit the finite alphabet of reflectance levels and enable a pixel-wise iterative inference for fast recovery. Numerical results confirm the effectiveness of the proposed method.
Unveiling the physical mechanism behind pistol shrimp cavitation (2017)

Snapping shrimps use a special shaped claw to generate a cavitating high speed water jet. Cavitation formed in this way, may be used for hunting/stunning prey and communication. The present work is a novel computational effort to provide insight on the mechanisms of cavitation formation during the claw closure. The geometry of the claw used here is a simplified claw model, based on prior experimental work. Techniques, such as Immersed Boundary and Homogenous Equilibrium Model (HEM), are employed to describe the claw motion and cavitating flow field respectively. The simulation methodology has been validated against prior experimental work and is applied here for claw closure at realistic conditions. Simulations show that during claw closure, a high velocity jet forms, inducing vortex roll-up around it. If the closure speed is high enough, the intensity of the swirling motion is enough to produce strong depressurization in the vortex core, leading to the formation of a cavitation ring. The cavitation ring moves along the jet axis and, soon after its formation, collapses and rebounds, producing high pressure pulses.
Influence du rapport E/C sur l'hydratation, la microstructure et les déformations endogènes de pâtes de ciment durcies (2001)

ABSTRACT This work deals with the influence of the W/C ratio on the cement hydration and on the chemical characteristics and the microstructure of hydrated compounds. Results obtained with various techniques show that the W/C ratio has a significant influence on the structural characteristics of the hydrated cement pastes. Whatever the time of hydration, it appears that the materials have a different behaviour when W/C is higher than 0.40. This limit could correspond to a “percolation threshold” of water within the capillary pore network. When W/C increases, the amount of calcium hydroxide, referred to a unit mass of initial cement, increases whereas the CaO/SiO2 of C-S-H has a tendency to decrease. Moreover, for the autogenous deformations recorded during hydration, a swelling phase is exhibited before shrinkage phase with high W/C ratios. In the case of low W/C ratios, only shrinkage is observed.
Atmospheric Pressure Cold Plasma: A Friendly Environment for Dry Enzymes (2018)

Abstract A comprehensive study of the interaction of cold atmospheric pressure plasmas (CAPs) with dry enzymes is conducted to identify the experimental conditions that allow preserving enzyme functionality. Glucose oxidase (GOx) dry deposits are exposed to dielectric barrier discharges fed with pure helium, helium–oxygen, and helium–ethylene mixtures. The GOx loses functionality upon exposure to He/O 2 CAP due to dry etching. X‐ray photoelectron spectroscopy reveals that, in parallel with the ablation, there are modifications of the chemical structure of the surface of the enzyme deposit that decrease the etching rate and eventually lead to a “crust” with a strong resistance against the ablation, responsible of process termination. Interestingly, the customary conditions used for plasma‐enhanced chemical vapor deposition using helium–ethylene mixtures (applied voltage &lt;1.1 kV rms and exposure time ≤10 min) are friendly for GOx. It is therefore possible to immobilize enzymes by overcoating with a plasma‐deposited thin film, fully retaining enzyme functionality.
CT Fluoroscopy–guided Biopsy of the Lung or Upper Abdomen with a Breath-hold Monitoring and Feedback System: A Prospective Randomized Controlled Clinical Trial (2005)

A breath-hold monitoring and feedback system allows depiction of mobile target lesions throughout CT fluoroscopy-guided biopsy of the lung and upper abdomen.
Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism (2013)

Dendritic cells (DCs) in the intestinal lamina propria (LP) are composed of two CD103(+) subsets that differ in CD11b expression. We report here that Langerin is expressed by human LP DCs and that transgenic human langerin drives expression in CD103(+)CD11b(+) LP DCs in mice. This subset was ablated in huLangerin-DTA mice, resulting in reduced LP Th17 cells without affecting Th1 or T reg cells. Notably, cognate DC-T cell interactions were not required for Th17 development, as this response was intact in huLangerin-Cre I-Aβ(fl/fl) mice. In contrast, responses to intestinal infection or flagellin administration were unaffected by the absence of CD103(+)CD11b(+) DCs. huLangerin-DTA x BatF3(-/-) mice lacked both CD103(+) LP DC subsets, resulting in defective gut homing and fewer LP T reg cells. Despite these defects in LP DCs and resident T cells, we did not observe alterations of intestinal microbial communities. Thus, CD103(+) LP DC subsets control T cell homeostasis through both nonredundant and overlapping mechanisms.
Vaccine-elicited systemic and mucosal humoral responses of lactating rhesus monkeys vaccinated with the transmitted/founder HIV Envelope 1086C (2012)

Background We previously demonstrated that vaccination of lactating rhesus monkeys with a DNA prime/ vector boost strategy induces strong SIV-specific cellular immune responses, but limited Envelope-specific humoral responses in breast milk. Therefore, we sought to improve vaccine-elicited Envelope-specific antibody responses in the milk compartment by using a transmitted/founder (T/F) HIV Envelope immunogen in a prime-boost strategy modeled after that of the moderately-successful RV144 HIV vaccine trial. Methods
Supplemental Table 1 from The Tyrosine Kinase Adaptor Protein FRS2 Is Oncogenic and Amplified in High-Grade Serous Ovarian Cancer (2023)

&lt;p&gt;Supplemental Table 1. List of 50 genes that are specifically essential and amplified in ovarian cancer.&lt;/p&gt;
Laser Assisted Patterning Of A-Si:H: Detailed Investigation Of Laser Damage (2017)

A detailed investigation of the laser damage to amorphous silicon (a-Si:H) layers patterned by laser ablation (LA) and wet chemical etching is presented. This approach can be applied to pattern the rear side of silicon heterojunction interdigitated back-contact solar cells. Only the top sacrificial a-Si:H laser-absorbing layer of an a-Si:H/SiO<sub>x</sub>/a-Si:H/c-Si stack is ablated. Laser damage in the bottom a-Si:H layer and a-Si:H/c-Si interface is analyzed by both scanning electron microscopy and transmission electron microscopy. We show that the a-Si:H/c-Si passivation is degraded by laser damage and that this degradation can be diminished by increasing laser processing speed. This is attributed to a decrease of laser-irradiated area, and particularly smaller overlapping zones of adjacent laser pulses. The re-passivation quality after LA and wet etching is similar to that of as-passivated samples. This indicates that laser damage is not present in the bulk c-Si substrate but only in the a-Si:H passivation layer, which is removed during subsequent wet etching, thus allowing high quality repassivation.
Mechanotransduction through Cytoskeleton (2002)

The goal of this project was to characterize the molecular mechanism by which cells recognize and respond to physical forces in their local environment. The project was based on the working hypothesis that cells sense mechanical stresses, such as those due to gravity, through their cell surface adhesion receptors (e.g., integrins) and that they respond as a result of structural arrangements with their internal cytoskeleton (CSK) which are orchestrated through use of tensegrity architecture. In this project, we carried out studies to define the architectural and molecular basis of cellular mechanotransduction. Our major goal was to define the molecular pathway that mediates mechanical force transfer between integrins and the CSK and to determine how mechanical deformation of integrin-CSK linkages is transduced into a biochemical response. Elucidation of the mechanism by which cells sense mechanical stresses through integrins and translate them into a biochemical response should help us to understand the molecular basis of the cellular response to gravity as well as many other forms of mechanosensation and tissue regulation. The specific aims of this proposal were: 1. To define the molecular basis of mechanical coupling between integrins, vinculin, and the actin CSK; 2. To develop a computer simulation of how mechanical stresses alter CSK structure and test this model in living cells; 3. To determine how mechanical deformation of integrin-CSK linkages is transduced into a biochemical response.
Supplementary Figure S5: Elevated ATF3 after AD and edelfosine treatments inhibits AR promoter activity in LNCaP cells. from Edelfosine Promotes Apoptosis in Androgen-Deprived Prostate Tumors by Increasing ATF3 and Inhibiting Androgen Receptor Activity (2023)

&lt;p&gt;Androgen deprived LNCaP cells were co-transfected with 5 µg of ARE-luciferase reporter constructs, renilla luciferase and siATF3 (10 nM), followed by treatment with edelfosine (5 µM) and R1881 (5 nM). Cells were harvested and lysed after 24 hours following treatment and assayed for ARE reporter activity. Luciferase expression of each sample was measured using dual luciferase reporter gene assay system (Promega Corp., Madison, WI). The data represents the ratio between firefly/renilla luciferase activities. The mean values {plus minus} SEM of three independent experiments are shown. *p &lt; 0.05, compared to group with R1881 alone (one way ANOVA).&lt;/p&gt;
Heavy metal removal from water using the metallogelation properties of a new glycolipid biosurfactant (2022)

Abstract Water pollution by heavy metals is a problem in both western and developing countries. Heavy metal pollution can be associated with human activity, such as wastewaters from processing of ore mining, but also to simple contamination from metal‐rich soils. Whichever the case, chemical and physical methods are generally employed to depollute water. Since most chemicals are themselves polluting agents, there is an increasing interest in finding biobased and biodegradable alternative chemicals, both efficient in removing metals and benign to the environment. Biosurfactants are green chemicals produced by fermentation of yeasts and bacteria and with a good environmental score. Among many applications, this class of compounds has been used to remove heavy metals from contaminated soils. Within this framework, we propose a new mechanism of depolluting water using a glucolipid biosurfactant, G‐C18:1, composed of glucose (G) and a C18:1 fatty acid (oleic acid). This compound is able to form a metallogel by complexing cations in water, thus trapping heavy metals (Cu 2+ , Ni 2+ , Cr 2+ , and Co 2+ ) in the gel phase. This mechanism allows to remove up to 95% for cobalt and 88 ± 10%, 80 ± 3%, and 59 ± 6% for Cu 2+ , Ni 2+ , and Cr 2+ , respectively. A dedicated structural study shows that this is possible because positively charged species induce gelation of G‐C18:1 through a micelle‐to‐wormlike phase transition, most likely driven by a charge neutralization process. This work shows that wise control of the nanoscale properties of green chemicals can strongly benefit to develop a sustainable future.
Folate metabolism genes, dietary folate and response to antidepressant medications in late‐life depression (2012)

The major finding from this study is that the MTRR A66G genotype predicts response to selective serotonin reuptake inhibitor antidepressants in late life depression.
Cognitive-behavioural treatment for workers with chronic spinal pain: a matched and controlled cohort study in Sweden. (1994)

An ambulatory multimodal cognitive-behavioural treatment programme (MMCBT) for Swedish workers with chronic spinal pain was formally evaluated. The design was a matched cohort study with three repeated measures done in two groups of 35 referred patients (one exposed to MMCBT and controls exposed to usual care). The MMCBT package includes standardised modules of physical treatment, cognitive-behavioural treatment, education of worker patients, and education of subjects' supervisors. The primary outcome variables assessed were absenteeism, disability, pain, and depression. Because of a change in Swedish sick leave compensation laws affecting records of absence during the study period, absenteeism could not be reliably measured among controls. The trend, however, suggested a reduction of absenteeism among the subjects in the MMCBT cohort. The findings for disability, pain, and depression all showed clinically important and significant beneficial changes (ANOVA for repeated measures: disability p = 0.05; pain p = 0.001; depression p = 0.01). The direction of the improvements and the size of effect were coherent and clinically plausible. The benefits were only among the women in the study. These comprised 74% of each group. Further research on larger sample sizes and in cohorts more representative of the whole country are needed to confirm these encouraging findings and to explore how the benefits might be extended to men.