gebhart/patrepeval huggingface dataset:
Recent studies of glycolipid and glycoprotein profiles and characterization of the major glycolipid antigen in gastric cancer of a patient of blood group genotype pp (Tja-) first studied in 1951. (1982)

Abstract The lyophilized gastric tumor tissue (20 mg) of the patient (D. J.) studied serologically in 1951 absorbed 16 to 32 agglutinating units of her own stimulated antibody (1:512) induced by a test injection of 25 ml of incompatible blood from an initial 1:4 to 1:8 titer. When in 1975 the lyophilized tissue (about 3.5 g) was located, it was mailed to Seattle for biochemical analysis of the antigens involved, and these investigations were not completed until 1982. This paper describes the glycolipids and glycoproteins in the gastric cancer tissue of a patient whose erythrocytes contained the first example of a very rare variant of the P system, identified as genotype pp (initially referred to as Tj a- ) and later shown to contain anti-P 1 PP k (anti-Tj a ) in her serum. Sodium dodecyl sulfate:polyacrylamide gel electrophoresis of the immunoprecipitates with anti-globoside, anti-P 1 , and anti-P 1 PP k of [ 3 H]galactose-labeled tissue extract demonstrated the major component in glycolipids and a few minor components in glycoproteins. The purified glycolipid fraction (upper neutral glycolipid) showed complement fixation with anti-P 1 PP k ; nevertheless, the glycolipid fraction contained neither globoside nor ceramide trihexoside. The major glycolipid had the same thin-layer chromatography mobility and antigenic reactivity as a new “x 2 glycolipid” of human erythrocytes which cross-reacts with anti-globoside antibodies, the pentasaccharide structure of which was identified as GalNAcβ1 → 3Galβ1 → 4GlcNAcβ1 → 3Galβ1 → 4Glcβ1 → 1Cer. The latter is a glycolipid with the same terminal structure as globoside and with an internal structure identical to paragloboside. Although the purified glycolipid fractions display a clear inhibition of anti-P 1 agglutinins, only a minor component had the same thin-layer chromatography mobility as P 1 glycolipid, which is a ceramide pentasaccharide susceptible to hydrolysis with fig α-galactosidase. It is possible that some other glycolipid having a more complex structure may also have P 1 activity. The results indicate that the tumor activated the synthesis of P 1 antigen but not the synthesis of the globo series glycolipid; it also showed an enhanced synthesis in the lacto series glycolipid with the same terminal structure as globoside. There are indications that this patient survived for 22 years, until 1973, when she died at 88 years from old age without developing any metastasis, while her younger compatible sib, also of genotype pp (Tj a- ), died of cancer of the uterus and metastasis at the age of 63.
Real-Time Imaging of Tunable Adenosine 5-Triphosphate Release from an MCM-41-Type Mesoporous Silica Nanosphere-Based Delivery System (2005)

We studied a mesoporous silica nanosphere (MSN) material with tunable release capability for drug delivery applications. We employed luciferase chemiluminescence imaging to investigate the kinetics and mechanism of the adenosine 5-triphosphate (ATP) release with various disulfide-reducing agents as uncapping triggers. ATP molecules were encapsulated within the MSNs by immersing dry nanospheres in aqueous solutions of ATP followed by capping of the mesopores with chemically removable caps, such as cadmium sulfide (CdS) nanoparticles and poly(amido amine) dendrimers (PAMAM), via a disulfide linkage. By varying the chemical nature of the “cap” and “trigger” molecules in our MSN system, we discovered that the release profiles could indeed be regulated in a controllable fashion.
Topical noninvasive retinal drug delivery of a tyrosine kinase inhibitor: 3% cediranib maleate cyclodextrin nanoparticle eye drops in the rabbit eye (2022)

Cediranib maleate in γ-cyclodextrin nanoparticles were stable to heat in presence of stabilizers. The drug as eye drops reached the retina in concentrations that are more than 100 times higher than the 0.4 nM IC<sub>50</sub> value reported for the VEGF type-II receptor and thus, presumably, above therapeutic level. These results suggest that γ-cyclodextrin-based cediranib maleate eye drops deliver effective drug concentrations to the retina in rabbits after a single-dose administration.
Synthesis route of microporous metallophosphates by in situ generation of the structure directing agent: the gallophosphate Ea-TREN GaPO (2007)

Congrès du 12 au 17.08.2007
A Technique toSuppress Tail Current Flicker Noise inCMOS LCVCOs (2006)

A technique toreduce close-in phasenoise inCMOS LC voltage controlled oscillators isproposed. In CMOS differential LC oscillators, theup-conversion offlicker noise mainly determines theclose-in phasenoise. Theflicker noise of thebiascurrent isa majorcomponent contributing tothe overall lowfrequency noise. Inthis paper, a switched biasing - technique tosuppress theflicker noise ofthebiascircuit is presented. A 1.8v2.4GHzdifferential LCVCO isdesigned ina AM
Fast Diagnostics of BRAF Mutations in Biopsies from Malignant Melanoma (2016)

According to the American skin cancer foundation, there are more new cases of skin cancer than the combined incidence of cancers of the breast, prostate, lung, and colon each year, and malignant melanoma represents its deadliest form. About 50% of all cases are characterized by a particular mutation BRAF(V600E) in the BRAF (Rapid Acceleration of Fibrosarcoma gene B) gene. Recently developed highly specific drugs are able to fight BRAF(V600E) mutated tumors but require diagnostic tools for fast and reliable mutation detection to warrant treatment efficiency. We completed a preliminary clinical trial applying cantilever array sensors to demonstrate identification of a BRAF(V600E) single-point mutation using total RNA obtained from biopsies of metastatic melanoma of diverse sources (surgical material either frozen or fixated with formalin and embedded in paraffin). The method is faster than the standard Sanger or pyrosequencing methods and comparably sensitive as next-generation sequencing. Processing time from biopsy to diagnosis is below 1 day and does not require PCR amplification, sequencing, and labels.
425 Potential analysis of decentralized regional supply energy systems in redevelopment area (2006)

The energy saving in urban area is one of the most important issues recently. As the redevelopment of the medium scale area is more frequent than that of the large scale area, it is meaningful to investigate the energy saving potential of regional energy supply systems for the medium scale area. In the study, the simulation of the regional energy supply systems installed in the medium scale area was performed. Four systems, namely, the individual system, the district heating and cooling system, the energy center, and the micro-grid, were evaluated by comparison. The energy saving potential was calculated against the individual system. It was found that the micro-grid could achieve the energy saving by 16%, which was the largest.
Enhanced Phototrophic Biomass Productivity through Supply of Hydrogen Gas (2020)

Industrial production of phototrophic microorganisms is often hindered by low productivity due to limited light availability and therefore requires large land areas. This letter demonstrates that supply of hydrogen gas (H<sub>2</sub>) increases in phototrophic biomass productivity compared to a culture growing on light only. Experiments were performed growing <i>Synechocystis sp.</i> in batch bottles, with and without H<sub>2</sub> in the headspace, which were exposed to light intensities of 70 and 100 μmol/m<sup>2</sup>/s. At 70 μmol/m<sup>2</sup>/s with H<sub>2</sub>, the average increase in biomass was 96 mg DW/L/d, whereas at 100 μmol/m<sup>2</sup>/s without H<sub>2</sub>, the average increase in biomass was 27 mg DW/L/d. Even at lower light intensity, the addition of H<sub>2</sub> tripled the biomass yield compared to growth under light only. Photoreduction and photosynthesis occurred simultaneously, as both H<sub>2</sub> consumption and O<sub>2</sub> production were measured during biomass growth. Photoreduction used 1.85 mmol of H<sub>2</sub> to produce 1.0 mmol of biomass, while photosynthesis produced 1.95 mmol of biomass. After transferring the culture to the dark, growth ceased, also in the presence of H<sub>2</sub>, showing that both light and H<sub>2</sub> were needed for growth. A renewable H<sub>2</sub> supply for higher biomass productivity is attractive since the combined efficiency of photovoltaics and electrolysis exceeds the photosynthetic efficiency.
Efficacy of Mixtures of Magnesium, Citrate and Phytate as Calcium Oxalate Crystallization Inhibitors in Urine (2015)

The synergistic effect between magnesium and phytate on calcium oxalate crystallization suggests that a combination of these 2 compounds may be highly useful as antilithiasis therapy.
Laser Welding of Ruptured Intestinal Tissue Using Plasmonic Polypeptide Nanocomposite Solders (2013)

Approximately 1.5 million people suffer from colorectal cancer and inflammatory bowel disease in the United States. Occurrence of leakage following standard surgical anastomosis in intestinal and colorectal surgery is common and can cause infection leading to life-threatening consequences. In this report, we demonstrate that plasmonic nanocomposites, generated from elastin-like polypeptides (ELPs) cross-linked with gold nanorods, can be used to weld ruptured intestinal tissue upon exposure to near-infrared (NIR) laser irradiation. Mechanical properties of these nanocomposites can be modulated based on the concentration of gold nanorods embedded within the ELP matrix. We employed photostable, NIR-absorbing cellularized and noncellularized GNR-ELP nanocomposites for ex vivo laser welding of ruptured porcine small intestines. Laser welding using the nanocomposites significantly enhanced the tensile strength, leakage pressure, and bursting pressure of ruptured intestinal tissue. This, in turn, provided a liquid-tight seal against leakage of luminal liquid from the intestine and resulting bacterial infection. This study demonstrates the utility of laser tissue welding using plasmonic polypeptide nanocomposites and indicates the translational potential of these materials in intestinal and colorectal repair.
Spatial-frequency Analysis of the Anatomical Differences in Hamstring Muscles (2021)

Spatial frequency analysis (SFA) is a quantitative ultrasound method that characterizes tissue organization. SFA has been used for research involving tendon injury, but may prove useful in similar research involving skeletal muscle. As a first step, we investigated if SFA could detect known architectural differences within hamstring muscles. Ultrasound B-mode images were collected bilaterally at locations corresponding to proximal, mid-belly, and distal thirds along the hamstrings from 10 healthy participants. Images were analyzed in the spatial frequency domain by applying a two-dimensional Fourier Transform in all 6.5 × 6.5 mm kernels in a region of interest corresponding to the central portion of the muscle. SFA parameters (peak spatial frequency radius [PSFR], maximum frequency amplitude [Mmax], sum of frequencies [Sum], and ratio of Mmax to Sum [Mmax%]) were extracted from each muscle location and analyzed by separate linear mixed effects models. Significant differences were observed proximo-distally in PSFR (<i>p</i> = .039), Mmax (<i>p</i> < .0001), and Sum (<i>p</i> < .0001), consistent with architectural descriptions of the hamstring muscles. These results suggest that SFA can detect regional differences of healthy tissue structure within the hamstrings-an important finding for future research in regional muscle structure and mechanics.
Precision control of eluted activity from a Sr/Rb generator for cardiac positron emission tomography (2005)

A rubidium-82 (/sup 82/Rb) elution system is described for use with clinical positron emission tomography. The system is self-calibrating with 1.4% repeatability, independent of generator activity and elution flow rate. Saline flow is switched between a /sup 82/Sr//sup 82/Rb generator and a bypass line to achieve a constant activity elution of /sup 82/Rb. In the present study, pulse width modulation (PWM) of a solenoid valve is compared to simple threshold control as a means to simulate a proportional valve. A predictive-corrective control algorithm is developed which produces a constant activity elution within the constraints of long feedback delay and short elution time. Accurate constant-activity elutions of 10-70% of the total generator activity were demonstrated using the threshold comparison control. The adaptive-corrective control of the PWM valve provided a substantial improvement in precision of the steady-state output.
Recombinant factor VIIa use in cardiac surgery--expanding the arsenal therapy for intractable bleeding? (2004)

A 72-year-old patient was admitted for mitral valve replacement because of infective endocarditis. Severe intractable bleeding in the early postoperative period was successfully treated with recombinant activated factor VII (rFVIIa). Thereafter, recovery was uneventful, and the patient was discharged on postoperative day 16. The current clinical aspects and experience of rFVIIa use in cardiac surgery are discussed.
Exploring the Challenges towards Lifelong Fact Learning (2018)

So far life-long learning (LLL) has been studied in relatively small-scale and relatively artificial setups. Here, we introduce a new large-scale alternative. What makes the proposed setup more natural and closer to human-like visual systems is threefold: First, we focus on concepts (or facts, as we call them) of varying complexity, ranging from single objects to more complex structures such as objects performing actions, and objects interacting with other objects. Second, as in real-world settings, our setup has a long-tail distribution, an aspect which has mostly been ignored in the LLL context. Third, facts across tasks may share structure (e.g., and ). Facts can also be semantically related (e.g., "liger" relates to seen categories like "tiger" and "lion"). Given the large number of possible facts, a LLL setup seems a natural choice. To avoid model size growing over time and to optimally exploit the semantic relations and structure, we combine it with a visual semantic embedding instead of discrete class labels. We adapt existing datasets with the properties mentioned above into new benchmarks, by dividing them semantically or randomly into disjoint tasks. This leads to two large-scale benchmarks with 906,232 images and 165,150 unique facts, on which we evaluate and analyze state-of-the-art LLL methods.
Tea: The Plant and its Manufacture; Chemistry and Consumpatin of the Beverage (2019)

Tea is second only to water in worldwide consumption. Tea estates have traditionally included areas given over to the growth of seed producing plants. The tea plant is easily and efficiently propagated by making use of leaf cuttings. Traditional tea phraseology refers to “two and a bud” as the desirable plucking standard for maximizing quality. Tea leaf, in common with all plant leaf matter, contains the full complement of genetic material, enzymes, biochemical intermediates, carbohydrates, protein, lipids, and structural elements normally associated with plant growth and photosynthesis. Green tea products benefit from the additional chlorophyll and amino acid production caused by shading, and tea used for production of green tea is generally shaded for some duration of time. Better knowledge of the physiological and health-promoting properties of tea could be obtained by more complete understanding of the chemistry of the mass of oxidized phenolic material, commonly known as thearubigens but better classified as unknown polyphenols.
An implementation of distributed shared memory (1991)

Abstract Shared memory is a simple yet powerful paradigm for structuring systems. Recently, there has been an interest in extending this paradigm to non‐shared memory architectures as well. For example, the virtual address spaces for all objects in a distributed object‐based system could be viewed as constituting a global distributed shared memory . We propose a set of primitives for managing distributed shared memory. We present an implementation of these primitives in the context of an object‐based operating system as well as on top of Unix.
First treatment of Crohn’s disease refractory anastomotic stricture with a lumen-apposing metallic stent suitable for colonoscopy (2021)

A 58-year-old patient with Crohn's disease and prior ileocecal resection, experienced repeated bouts of bowel occlusion related to a short and fibrotic anastomotic stricture despite several endoscopic dilations. To avoid further surgery, endoscopic stenting was chosen to relieve symptoms and prevent relapses.
Dynamic Infrared Gas Analysis from Longleaf Pine Fuelbeds Burned in a WindTunnel: Observation of Phenol in Pyrolysis and Combustion Phases (2020)

Abstract. Pyrolysis is the first step in a series of chemical and physical processes that produce flammable organic gases from wildland fuels that can result in a wildland fire. We report results using a new time-resolved Fourier transform infrared method that correlates the measured FTIR spectrum to an infrared thermal image sequence enabling identification and quantification of gases within different phases of the fire process. The flame from burning fuel beds composed of pine needles (Pinus palustris) and mixtures of sparkleberry, fetterbush and inkberry plants was the natural heat source for pyrolysis. Extractive gas samples were analyzed and identified in both static and dynamic modes synchronized to thermal infrared imaging: A total of 29 gases were identified including small alkanes, alkenes, aldehydes, nitrogen compounds and aromatics, most previously measured by FTIR in wildland fires. This study presents one of the first identifications of phenol associated with both pre-combustion and combustion phases, using ca. 1 Hz resolution. Preliminary results indicate ~ 2.5× greater phenol emission from sparkleberry and inkberry compared to fetterbush, with differing temporal profiles.
Forecasting Weather-Impacted Airport Capacities for Flow Contingency Management: Advanced Methods and Integration (2013)

ne goal of the Next Generation Air Transportation System (NextGen) is to develop strategic decision-making capabilities, which facilitate allocation of traffic management initiatives (TMIs) across the United States National Airspace System (NAS) over a full-day look-ahead horizon. In recent years, several promising concepts and methodologies for such strategic traffic management have been advanced, including our team's flow contingency management (FCM) solution. A key thrust of these strategic traffic management solutions, including FCM, is the development of stochastic forecasts of weather impact in both the en route and terminal area airspace. FCM, in particular, requires forecast scenarios (possible futures) of weather-constrained capacities, including sector capacities and airport arrival and departure rates (AARs and ADRs), over a full day forecast horizon. Several recent studies have introduced promising techniques for forecasting weather impacts and generating impact scenarios 1–3 , however many challenges remain in developing and validating useful and accurate models. The work presented here contributes to the research effort on strategic forecasting of weather-impacted airport capacities (specifically, AARs). Although AAR and ADR forecasting has been extensively studied, most efforts have focused on shorter time horizons (up to four hours 4 ) or are terminal-specific (e.g., the stratus forecast for San Francisco International Airport 5 ). However, FCM requires a generic probabilistic methodology for AAR prediction, albeit one that only needs to predict significant capacity reductions rather than detailed trends in runway configurations and capacity. Recently, Buxi and Hansen introduced two methodologies for probabilistic forecasting of AAR scenarios over a full-day horizon from terminal-area forecasts 6 . These approaches are promising for FCM, but depend on the presence of similar full-day TAF profiles in the historical record, and also do not account for convective weather. In our previous works, we introduced alternative regression-based approaches for prediction in the context of several case studies, and studied the incorporation of convective-weather forecasts in terminal capacity prediction. However, these initial studies stopped short of introducing a generic prediction algorithm, and also did not consider the wide range of forecast products that could be leveraged in AAR prediction. In this study, we introduce a multinomial-logistic-regression-based methodology for full-day AAR prediction for arbitrary airports, for use in the FCM solution. The paper is organized as follows. In Section II, we introduce the proposed regression methodology in generality, including both regression-model construction and model deployment for FCM. In Section III, we present two case studies for Boston Logan International Airport (KBOS)
Sequence-defined oligomer as a modular platform for selective sub-picomolar detection and removal of Hg<sup>2+</sup> (2021)

A modular synthetic platform for selective sensing and removal of Hg 2+ was developed.
A Retrospective Study on the Efficacy and Complications of Q-Switched Alexandrite Laser in the Treatment of Acquired Bilateral Nevus of Ota-Like Macules (2001)

QS alexandrite appears to be effective in the treatment of ABNOM. Postoperative pigmentary changes were frequent and the use of topical depigmentary agents was necessary to achieve a satisfactory result. Transient hypopigmentation risk was high, affecting up to 50% of the patients. Further study is warranted to compare the efficacy and complications of different laser systems in the treatment of this condition.
Imaging-Guided Gene Therapy of Experimental Gliomas (2007)

To further develop gene therapy for patients with glioblastomas, an experimental gene therapy protocol was established comprising a series of imaging parameters for (i) noninvasive assessment of viable target tissue followed by (ii) targeted application of herpes simplex virus type 1 (HSV-1) amplicon vectors and (iii) quantification of treatment effects by imaging. We show that viable target tissue amenable for application of gene therapy vectors can be identified by multitracer positron emission tomography (PET) using 2-(18)F-fluoro-2-deoxy-D-glucose, methyl-(11)C-L-methionine, or 3'-deoxy-3'-(18)F-fluoro-L-thymidine ([(18)F]FLT). Targeted application of HSV-1 amplicon vectors containing two therapeutic genes with synergistic antitumor activity (Escherichia coli cytosine deaminase, cd, and mutated HSV-1 thymidine kinase, tk39, fused to green fluorescent protein gene, gfp) leads to an overall response rate of 68%, with 18% complete responses and 50% partial responses. Most importantly, we show that the "tissue dose" of HSV-1 amplicon vector-mediated gene expression can be noninvasively assessed by 9-[4-(18)F-fluoro-3-(hydroxymethyl)butyl]guanine ([(18)F]FHBG) PET. Therapeutic effects could be monitored by PET with significant differences in [(18)F]FLT accumulation in all positive control tumors and 72% in vivo transduced tumors (P = 0.01) as early as 4 days after prodrug therapy. For all stably and in vivo transduced tumors, cdIREStk39gfp gene expression as measured by [(18)F]FHBG-PET correlated with therapeutic efficiency as measured by [(18)F]FLT-PET. These data indicate that imaging-guided vector application with determination of tissue dose of vector-mediated gene expression and correlation to induced therapeutic effect using multimodal imaging is feasible. This strategy will help in the development of safe and efficient gene therapy protocols for clinical application.
Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma (2023)

&lt;p&gt;A description of additional supplemental methods&lt;/p&gt;