gebhart/patrepeval huggingface dataset:
Visualizing personal trend on gnowsis Semantic Desktop (2008)

To let a user know the user's personal trend on the user's computer, this paper proposes a method to explore and visualize one's personal trend on the premise that the Gnowsis semantic desktop is used. The proposed method classifies information items into four attention areas with a popularity change measure by using three indicators (direct attention score (DAS), indirect attention score (IAS) (using spreading activation) and popularity change (PC)). Comparing the proposed method with two existing tools (PIMO timeline and PIMO cloud) in the gnowsis, this paper describes the following advantages about the proposed method: (1) To deal with both touched concepts and neighbor concepts, (2) To consider frequency, (3) To consider trend, (4) To catch seven operations in the gnowsis. Moreover, from an experimental usage, which shows more than three subjects answered the proposed method provided good results in every question, this paper suggests the proposed method would be useful to show one's personal trend.
5G Dual (<i>S</i>-/<i>Ka</i>-) Band Antenna Using Thick Patch Containing Slotted Cavity Array (2021)

An S-/Ka-band shared-aperture antenna with frequency switching function for 5G applications is proposed in this letter. The proposed antenna comprises a thick patch containing a slotted cavity array (TPCSCA), S-band feeding structure, and coaxial cables for Ka-band. The TPCSCA is designed using 16 Ka-band slotted cavity antennas inside an S-band thick patch. Half of these Ka-band antenna elements radiate a +45° slanted polarization wave, whereas the others radiate a -45° SP wave. These elements are arranged in the form of a checkerboard and fed by coaxial cables. The S-band feeding structure is designed as a microstrip-fed slot and operates the TPCSCA as a TM <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">010</sub> mode patch antenna in S-band. The measurement results show realized gains of 4.06-5.35 and 12.0-14.5 dBi over the S-band (3.44-3.56 GHz) and the Ka-band (27.54-28.46 GHz), respectively. The -3 dB beam steering coverage for the Ka-band is more than ±40° for both polarizations.
Detecting, Classifying, and Mapping Retail Storefronts Using Street-level Imagery (2020)

Up-to-date listings of retail stores and related building functions are challenging and costly to maintain. We introduce a novel method for automatically detecting, geo-locating, and classifying retail stores and related commercial functions, on the basis of storefronts extracted from street-level imagery. Specifically, we present a deep learning approach that takes storefronts from street-level imagery as input, and directly provides the geo-location and type of commercial function as output. Our method showed a recall of 89.05% and a precision of 88.22% on a real-world dataset of street-level images, which experimentally demonstrated that our approach achieves human-level accuracy while having a remarkable run-time efficiency compared to methods such as Faster Region-Convolutional Neural Networks (Faster R-CNN) and Single Shot Detector (SSD).
Role of RANKL (TNFSF11)-Dependent Osteopetrosis in the Dental Phenotype of Msx2 Null Mutant Mice (2013)

The MSX2 homeoprotein is implicated in all aspects of craniofacial skeletal development. During postnatal growth, MSX2 is expressed in all cells involved in mineralized tissue formation and plays a role in their differentiation and function. Msx2 null (Msx2 (-/-)) mice display complex craniofacial skeleton abnormalities with bone and tooth defects. A moderate form osteopetrotic phenotype is observed, along with decreased expression of RANKL (TNFSF11), the main osteoclast-differentiating factor. In order to elucidate the role of such an osteopetrosis in the Msx2 (-/-) mouse dental phenotype, a bone resorption rescue was performed by mating Msx2 (-/-) mice with a transgenic mouse line overexpressing Rank (Tnfrsf11a). Msx2 (-/-) Rank(Tg) mice had significant improvement in the molar phenotype, while incisor epithelium defects were exacerbated in the enamel area, with formation of massive osteolytic tumors. Although compensation for RANKL loss of function could have potential as a therapy for osteopetrosis, but in Msx2 (-/-) mice, this approach via RANK overexpression in monocyte-derived lineages, amplified latent epithelial tumor development in the peculiar continuously growing incisor.
SCF E3 ligase F‐box protein complex SCF <sup>FBXL19</sup> regulates cell migration by mediating Rac1 ubiquitination and degradation (2013)

Rac1, a member of the Rho family of GTPases, regulates diverse cellular functions, including cytoskeleton reorganization and cell migration. F-box proteins are major subunits within the Skp1-Cul1-F-box (SCF) E3 ubiquitin ligases that recognize specific substrates for ubiquitination. The role of F-box proteins in regulating Rac1 stability has not been studied. Mouse lung epithelial (MLE12) cells were used to investigate Rac1 stability and cell migration. Screening of an F-box protein library and in vitro ubiquitination assays identified FBXL19, a relatively new member of the F-box protein family that targets Rac1 for its polyubiquitination and proteasomal degradation. Overexpression of FBXL19 decreased both Rac1 active and inactive forms and significantly reduced cellular migration. Protein kinase AKT-mediated phosphorylation of Rac1 at serine(71) was essential for FBXL19-mediated Rac1 ubiquitination and depletion. Lysine(166) within Rac1 was identified as a polyubiquitination acceptor site. Rac1(S71A) and Rac1(K166R) mutant proteins were resistant to FBXL19-mediated ubiquitination and degradation. Further, ectopically expressed FBXL19 reduced cell migration in Rac1-overexpressing cells (P<0.01, Rac1 cells vs. FBXL19+Rac1 cells), but not in Rac1 lysine(166) mutant-overexpressing cells. FBXL19 diminished formation of the migratory leading edge. Thus, SCF(FBXL19) targets Rac1 for its disposal, a process regulated by AKT. These findings provide the first evidence of an F-box protein targeting a small G protein for ubiquitination and degradation to modulate cell migration.
Imagerie fonctionnelle de la mémoire aux stades précoces de la maladie d'Alzheimer : dysfonctionnements et mécanismes compensatoires (2010)

Depuis une quinzaine d'annees, de nombreux travaux d'imagerie en activation ont ete entrepris dans la maladie d'Alzheimer et dans la phase predementielle de la maladie, c'est-a-dire chez des patients repondant aux criteres de troubles cognitifs legers. Ces etudes permettent d'examiner les substrats cerebraux des troubles cognitifs et d'analyser les signes precurseurs de la maladie. Elles servent egalement a mettre en evidence les mecanismes de compensation mis en place pour faire face aux anomalies neuropathologiques. Du fait de son atteinte privilegiee et precoce, la memoire, et notamment la memoire episodique, a tout particulierement suscite l'interet des chercheurs. Cet article se propose de synthetiser les principales donnees, obtenues aupres de patients et concernant la memoire episodique, la memoire semantique et la memoire de travail. Il ressort principalement des resultats une alteration fonctionnelle de structures cles associees a chacun de ces systemes mnesiques. Le dysfonctionnement affecte tant les activations que les desactivations induites par des tâches cognitives. En outre, des phenomenes de plasticite cerebrale sont observes. Ils pourraient refleter la mise en place de processus compensatoires. Aux stades predementiels, ces mecanismes reposeraient surtout sur des structures attendues compte tenu des processus en jeu. L'entree dans la demence se traduirait par des modifications compensatoires moins specifiques et plus distribuees.
ECONO: Express coherence notifications for efficient cache coherency in many-core CMPs (2013)

It is commonly stated that a directory-based coherence protocol is the design of choice to provide maximum performance in coherence maintenance for shared-memory many-core CMPs. Nevertheless, new solutions are emerging to achieve acceptable levels of on-chip area overhead and energy consumption to also meet scalability. In this work, we propose the Express COherence NOtification (ECONO) protocol, a coherence protocol aimed at providing high performance with minimal on-chip area and energy consumption for superior scalability. To maintain coherence, ECONO relies on express coherence notifications which are broadcast atomically over a dedicated lightweight and power-efficient on-chip network leveraging state-of-the-art technology. We implement and evaluate ECONO utilizing full-system simulation, a representative set of benchmarks, and compare it against two contemporary coherence protocols: Hammer and Directory. While ECONO achieves slightly better performance than Directory, our proposal does not need to encode sharer sets like in Hammer, saving significant on-chip area and energy even when considering the extra hardware resources required by ECONO. Projections for a 1024-core CMP reveal that, in comparison to one of the most scalable directory-based protocols to date, ECONO entails more than 2× less on-chip storage overhead while keeping with reasonable power dissipation.
Efficacy and safety of pantoprazole 20 mg once daily treatment in patients with ulcer-like functional dyspepsia (2008)

Results of this study suggest that pantoprazole 20 mg is more efficacious than placebo, and is a well-tolerated treatment for relieving epigastric pain in patients with ulcer-like functional dyspepsia. Further research is needed to confirm these findings.
Thermal Properties (2013)

This chapter contains sections titled: Introduction Thermal Conductivities Atomic Displacement Parameters Heat Capacities Thermal Expansion Thermal Stability Summary and Conclusions Appendix References
Polarization Scattering Matrix and Doppler Joint Estimation Based on Multichannel Spectrum Interpolation Clean (2023)

Polarization and micro-Doppler signatures are widely used for target detection and recognition in harsh sensing environments. However, accurately estimating polarization scattering matrices and Doppler frequencies of scattering centers (SCs) remains challenging. This letter incorporates the multichannel spectrum interpolation (MSI) with the CLEAN algorithm. The proposed algorithm can estimate the Doppler frequencies and scattering matrices of target SC from fully polarized data with high precision. Compared with the traditional detection-after-imaging workflow, the proposed method takes an iterative suppression technique, which improves the estimation accuracy and reduces detection time. The effectiveness of the proposed method is verified based on the simulation and actual radar data. The estimation accuracy measured by polarized similarity is 99.9%, and the normalized root-mean-squared error (RMSE) of the estimated Doppler frequency is 4.8% in simulation.
Transmission electron microscopy study of the activated slip systems and the dislocation structures in B2-type CoZr and CoHf polycrystals (1993)

Abstract The Burgers vectors, the associated slip plane and the morphological feature of dislocations activated in B2-type CoZr and CoHf polycrystals were investigated by means of bright and dark field transmission electron microscopy (TEM). In both intermetallic compounds, CoZr and CoHf, the slip systems were determined to be <100>{011} at whole testing deformation temperatures. It was also shown that the <100> dislocations activated in both CoZr and CoHf were not dissociated. Based on these TEM observations, the micro-mechanism associated with the strength anomaly generally observed in IVa-VIII B2-type intermetallic compounds is briefly discussed.
Abstract 17075: Preferential Targeting of Bnip3 Isoforms to Mitochondria or Endoplasmic Reticulum During Metabolic Stress Promotes Autophagy or Cell Survival of Post-Natal Ventricular Myocytes (2011)

Autophagy is an evolutionary conserved process that allows cells to recycle or discard macromolecular constituents or damaged organelles during times of metabolic crisis. Alternative mRNA splicing is a versatile mechanism by which cells generate proteins with different or even antagonistic properties. Herein, we show that inclusion or skipping of exon3 of Bnip3 mRNA generates proteins with distinct and opposing actions on autophagy and cell survival. Metabolic stress imposed by hypoxia or nutrient deprivation resulted in the synthesis of two Bnip3 mRNA isoforms in post-natal ventricular myocytes in vitro and in vivo. Notably, one Bnip3 mRNA comprised of exons 1 through 6 encoded a protein of 26kDa, while a second mRNA generated by the fusion of exon2 and exon4 encoded a truncated Bnip3 protein of 8.2kDa. Sequence analysis revealed the truncated isoform encodes a conserved C-terminus domain that exclusively targets Bnip3 to the endoplasmic reticulum (ER) and not mitochondrion. While the 26kDa Bnip3 induced mitochondrial perturbations and autophagy, the spliced isoform suppressed Bnip3 induced mitochondrial defects and autophagy. Interestingly switching from glucose to fatty metabolism by supplementing nutrient deprived ventricular myocytes with carnitine but not pyruvate preferentially accumulated the spliced isoform of Bnip3 and the association of Bcl-2/Beclin-1 complexes at the ER, while suppressing autophagy. Furthermore, C-terminal domain mutations of the spliced variant defective for ER targeting sensitized cardiac myocytes to mitochondrial perturbations and apoptosis. To our knowledge our data provide the first direct evidence for a novel survival mechanism whereby the metabolic status of the cell programs autophagy or apoptosis by preferentially targeting Bnip3 isoforms to mitochondria or ER during metabolic stress.
Seismic Inversion Workflow for Sand Stringers Characterization in Offshore Saudi Arabia (2009)

Abstract We describe an optimized seismic inversion workflow for an improved characterization of mid-Cretaceous sand stringers in the northern offshore area of Saudi Arabia. The first step of the workflow consists of analyzing the impact on inversion results for critical processing steps such as random and coherent noise reduction or prestack time migration. In a second step, a new "inversion friendly" processing sequence, including a patented in-house data reconstruction technique, is then defined in order to mitigate noise while preserving the recorded seismic amplitude variation with offset. The last step of the workflow consists of inverting the processed seismic dataset for Vp/Vs, and interpreting the results in terms of sand stringer probability. This workflow is illustrated on a dataset covering an area where one extended reach lateral is to be drilled.
Microbial bioinformatics 2020 (2016)

Microbial bioinformatics in 2020 will remain a vibrant, creative discipline, adding value to the ever-growing flood of new sequence data, while embracing novel technologies and fresh approaches. Databases and search strategies will struggle to cope and manual curation will not be sustainable during the scale-up to the million-microbial-genome era. Microbial taxonomy will have to adapt to a situation in which most microorganisms are discovered and characterised through the analysis of sequences. Genome sequencing will become a routine approach in clinical and research laboratories, with fresh demands for interpretable user-friendly outputs. The "internet of things" will penetrate healthcare systems, so that even a piece of hospital plumbing might have its own IP address that can be integrated with pathogen genome sequences. Microbiome mania will continue, but the tide will turn from molecular barcoding towards metagenomics. Crowd-sourced analyses will collide with cloud computing, but eternal vigilance will be the price of preventing the misinterpretation and overselling of microbial sequence data. Output from hand-held sequencers will be analysed on mobile devices. Open-source training materials will address the need for the development of a skilled labour force. As we boldly go into the third decade of the twenty-first century, microbial sequence space will remain the final frontier!
Transcription et exploitation des données : exigences en vue de la formulation de requêtes semi-automatisées (2005)

Groupe ICOR <br />Abbès Ramzi<br /> <br />Transcription et exploitation des données : exigences en vue de la formulation de requêtes semi-automatisées<br /><br />La complexité et la richesse des transcriptions de données orales interactives a longtemps nourri une démarche qualitative très méthodique mais a aussi rendu difficile l'exploitation automatique des données. Dans cette contribution, nous allons souligner les exigences et les questions soutendant l'élaboration de transcriptions « équipées » et de dispositifs de requête informatisés.
Light emitting fabric for photodynamic treatment of actinic keratosis (2017)

The integration of optical fibers into flexible textile structures, by using knitting or weaving processes can allow the development of flexible light sources. The paper aims to present a new technology: Light Emitting Fabrics (LEF), which can be used for example for PDT of Actinic Keratosis in Dermatology. The predetermined macro-bending of optical fibers, led to a homogeneous side emission of light over the entire surface of the fabric. Tests showed that additional curvatures when applying the LEF on non-planar surfaces had no impact on light delivery and proved that LEF can adapt to the human morphology. The ability of the LEF, coupled with a 635nm LASER source, to deliver a homogeneous light to lesions is currently assessed in a clinical trial for the treatment of AK of the scalp by PDT. The low irradiance and progressive activation of the photosensitizer ensure a pain reduction, compared to discomfort levels experienced by patients during a conventional PDT session.
Role of C5a and C5a Receptor in Sepsis (2006)

In experimental sepsis (after cecal ligation and puncture, CLP) there is convincing evidence of complement activation, as there is in human sepsis. In addition, in sepsis involving rodents and humans, blood neutrophils have lost innate immune functions (chemotaxis, phagocytosis, the ability to produce H2O2). In CLP, and in neutrophils exposed to the complement anaphylatoxin, C5a, there is defective activation of MAPK (mitogen activated protein kinase), phosphorylation of p47, and inability to assemble NADPH oxidase. In experimental sepsis, the consumptive coagulopathy can be prevented by anti-C5a. Sepsis is also associated with loss of C5a receptor (C5aR) on neutrophils. In sepsis, thymocytes undergo apoptosis that is C5a mediated. All of these abnormalities occurring in experimental sepsis can be reversed by treatment with anti-C5a, with C5aR antagonist, with anti-C5aR, or with anti-IL-6, which causes upregulation of C5aR. These data suggest that generation of C5a during sepsis is harmful and that its interception or blockade of C5aR is beneficial.
Mixed-effects models and tolerance limits for mycotoxin measurements in food-stock lots (2016)

We describe mixed-effects models for aflatoxin measurements that were obtained from a set of incoming grain-delivery trucks at a pet food processing facility in Southeast Asia. Aflatoxin belongs to a group of highly toxic substances known as mycotoxins, the presence of which in food stocks is a major food safety concern around the world. The modeling objective is to evaluate the inter-truck and intra-truck variance components, and to estimate the influence of various factors on the measurements. These factors include, for example, the grain quality metrics from the individual suppliers, and the sample preparation and analytical processes used in the specific measurement protocols. Furthermore, we provide a brief description of how the modeling results can be used to obtain appropriate estimates for the one-sided tolerance limits, and, thereby, to evaluate the overall risk of high aflatoxin levels in the incoming truck lots.
Development of 1-N-11C-Methyl-l- and -d-Tryptophan for pharmacokinetic imaging of the immune checkpoint inhibitor 1-Methyl-Tryptophan (2015)

1-Methyl-tryptophan (1MTrp) is known as a specific inhibitor targeting the immune-checkpoint protein indoleamine-2,3-dioxygenase, in two stereoisomers of levorotary (L) and dextrorotary (D). A long-standing debate exists in immunology and oncology: which stereoisomer has the potential of antitumor immunotherapy. Herein, we developed two novel radioprobes, 1-N-(11)C-methyl-L- and -D-tryptophan ((11)C-L-1MTrp and (11)C-D-1MTrp), without modifying the chemical structures of the two isomers, and investigated their utility for pharmacokinetic imaging of the whole body. (11)C-L-1MTrp and (11)C-D-1MTrp were synthesized rapidly with radiochemical yields of 47 ± 6.3% (decay-corrected, based on (11)C-CO2), a radiochemical purity of >98%, specific activity of 47-130 GBq/μmol, and high enantiomeric purity. PET/CT imaging in rats revealed that for (11)C-L-1MTrp, the highest distribution of radioactivity was observed in the pancreas, while for (11)C-D-1MTrp, it was observed in the kidney. Ex vivo biodistribution confirmed the PET/CT results, indicating the differences in pharmacokinetics between the two isomers. Both (11)C-L-1MTrp and (11)C-D-1MTrp are therefore useful PET probes for delineating the distribution and action of the checkpoint inhibitor 1MTrp in vivo. This study represents the first step toward using whole-body and real-time insight to disentangle the antitumor potential of the two stereoisomers of 1MTrp, and it can facilitate the development of 1MTrp immunotherapy.
Xenogene vaccination in the therapy of cancer (2014)

Based on this compendium of results we believe that xenogene vaccination may soon become a well-established weapon in the fight against cancer.
Fischer Carbene Complexes. A New Tool for Heterocyclic Synthesis (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Maclaurin-series expansion approach to coupled queues with phase-type distributed service times (2017)

We propose an efficient numerical scheme for the evaluation of large-scale Markov processes that have a generator matrix that reduces to a triangular matrix when a certain rate is sent to zero. The methodology at hand is motivated by coupled queueing systems. Such systems are a natural abstraction f
Characterization of Tn <i>3000</i> , a Transposon Responsible for <i>bla</i> <sub>NDM-1</sub> Dissemination among Enterobacteriaceae in Brazil, Nepal, Morocco, and India (2015)

In Enterobacteriaceae, the blaNDM genes have been found in many different genetic contexts, and a wide diversity of plasmid scaffolds bearing those genes has been found. In August 2013, we identified NDM-1-producing Escherichia coli and Enterobacter hormaechei strains from a single rectal swab sample from a patient hospitalized in Rio de Janeiro, Brazil, who had no history of travel abroad. Complete DNA sequencing using the Illumina platform and annotation of the two plasmids harboring the blaNDM-1 gene, one from each strain, showed that they belonged to incompatibility groups IncFIIK and IncX3 and harbored a novel transposon named Tn3000. Similar genetic structures have been identified among other isolates in Brazil but also on plasmids from other continents. Our findings suggest that the blaNDM-1 gene may be transmitted by Tn3000 in different parts of the world.