gebhart/patrepeval huggingface dataset:
Population Pharmacokinetics of Sirolimus in Pediatric Patients With Neurofibromatosis Type 1 (2013)

Sirolimus clearance in children with NF1 is comparable with that in pediatric transplant patients. Clearance was most associated with body size parameters (BSA and total body weight) in children with NF1. When normalized for size, an age effect on clearance was observed in the youngest patients, most likely because of the maturational changes in drug absorption and metabolism. A mean dose of 2.0 mg/m twice a day was required for attainment of target trough concentrations of 10-15 ng/mL in children greater than 3 years of age who have NF1. The updated model will allow PK-guided individualized dosing of sirolimus in patients with NF1.
DETERMINE THE COMPETENCE OF DIFFERENT FRESH DIETS TO IMPROVE THE SPERMATOPHORE SUPERIORITY OF GIANT BLACK TIGER SHRIMP, PENAEUS MONODON (FABRICIUS, 1798) (2012)

The intention of the present study was to assess the effect of fresh natural food on spermatophore quality and analysis by the way of sperm weight, count, viability as well as the proximate analysis of offered food and shrimp brood stock. The experiment was carried out with the three following treatments; fresh squid, polychaete and beef liver up to 5 weeks. All parameters were measured by the starting of 3 rd week (15 days) and the end of the (35 days) of the experiment. Spermatophore quality was evaluated by spermatophore weight, sperm count, viability and proximate analysis of the treatment and shrimps. The content of three essential fatty acids, Arachidonic acid (AA), Eicosapentanoic acid (EPA) and Docosahexaenoic acid (DHA) from wild Penaeus monodon brood stock were evaluated in comparison with natural diet fed to P. monodon . Spermatophore of wild male brood stock contained higher levels of AA than those of artificial fed males. Polychaete has higher proportion of AA to EPA and DHA. At the end of the treatment the sperm viability and count, shrimp and spermatophore weight were significantly different among treatment and control (p<0.05). The present study concludes that the fresh squid diet is highly preferred over the diets influence on increasing the spermatophore quality, therefore use of fresh squid only is recommended for the maturation of male P. monodon brood stock. // //
Influence of Age, Anatomic Site and Race on Skin Roughness and Scaliness (1998)

&lt;b&gt;Background:&lt;/b&gt; Variations in skin roughness and scaliness between age groups, anatomic sites and race have been assumed but minimally quantified. &lt;b&gt;Objective:&lt;/b&gt; We quantitatively investigated skin roughness, scaliness and stratum corneum hydration as a function of age, anatomic site and race (white and black). &lt;b&gt;Methods:&lt;/b&gt; Skin roughness, scaliness and stratum corneum hydration were determined in vivo by noninvasive bioengineering and image analysis techniques in 22 female subjects grouped according to age (young and aged) and race (white and black). &lt;b&gt;Results:&lt;/b&gt; Skin roughness, scaliness and stratum corneum hydration varied significantly in different anatomic areas and age groups. There was no racial variation in skin hydration between any anatomic site, nor significant differences in roughness and scaliness between races, except for the preauricular area. Skin roughness was significantly increased in the aged, compared to the young at the preauricle, volar forearm, lower back, thigh and lower leg. Older women demonstrated significantly more scaling at the preauricle than younger women. Stratum corneum hydration correlated with scaliness. No significant correlation between stratum corneum hydration and skin roughness was observed. &lt;b&gt;Conclusion:&lt;/b&gt; Age and anatomic site but not race demonstrated a significant influence on skin roughness and scaliness. The desquamation index appears a good indicator of the status of stratum corneum hydration.
Full preclinical validation of the 123I-labeled anti-PSMA antibody fragment ScFvD2B for prostate cancer imaging (2016)

Due to its in vitro and in vivo properties, 123I-scFvD2B could be a promising tool for the early diagnosis of PCa, and may represent a molecular imaging option to monitor disease progression and assist in the clinical management of PCa patients.
Learning to Rank on Network Data (2013)

This paper proposes a method for learning to rank over network data. The ranking is performed with respect to a query object which can be part of the network or outside it. The ranking method makes use of the features of the nodes as well as the existing links between them. First, a neighbors-aware ranker is trained using a large margin pairwise loss function. Neighbors-aware ranker uses target neighbors scores in addition to objects’ content and therefore, the scoring is consistent in every neighborhood. Then, collective inference is performed using an iterative ranking algorithm, which propagates the results of rankers over the network. By formulating link prediction as a ranking problem, the method is tested on several networks, with papers/citations and webpages/hyperlinks . The results show that the proposed algorithm, which uses both the attributes of the nodes and the structure of the links, outperforms several other methods: a content-only ranker, a link-only one, a random walk method, a relational topic model, and a method based on the weighted number of common neighbors. In addition, the propagation algorithm improves results even when the query object is not part of the network, and scales eciently to large networks.
Tomography of mode-tunable coherent single-photon subtractor (2017)

We implement a single-photon subtractor that can be tuned to subtract a single photon exclusively from one mode or coherently from multiple modes. We experimentally characterize the device by employing coherent-state quantum process tomography.
Performance analysis of downhole acoustic communication in multiphase flow (2014)

There is a growing demand for wireless communication in oil & gas industry to improve well performance and overcome challenges in exploration, drilling, and production. One of the important challenges for the next generation of smart well completions is downhole wireless communication. This article investigates performance analysis of acoustic communication through a multiphase flow in a pipeline. A laboratory test setup was built to investigate acoustic propagation through multiphase flow. Effect of various flow and communication parameters (multiphase flow regimes, transmission frequency, and modulation techniques) on acoustic data communication were studied. The pipeline acts as an acoustic waveguide in which the frequency content and spectrum of the transmitted acoustic signal affects the bit rata and communication range. A multiphase acts as a frequency dependent fading channel, where a water-air interface acts as a reflector and scatters the incoming acoustic wave and introduces severe reverberations and energy loss. Also, it is observed that multiphase channel has a dispersive and non-linear nature, where received signal can have time spreading and frequency shift from original transmitted waveform. To reduce distortion phenomena and achieve better communication in multiphase flow over short range, a number of signal processing and communication techniques are proposed.
High throughput three-dimensional imaging cytometry based on single-shot optical diffraction tomography system (2021)

Optical diffraction tomography (ODT) has demonstrated its potential for revealing subcellular structures and quantitative compositions in living cells without chemical staining. Recently, we developed a deep-learning based algorithm to reconstruct the 3D refractive index (RI) maps of cells using a single raw interferogram, measured from an angle-multiplexed ODT system. Using this system, we demonstrated a high throughput 3D image cytometry method, in which a microfluidic chip for controlling cell flow is integrated in the ODT system. By flowing the cells in the chip and minimizing the camera exposure time, we can achieve 3D imaging of over 6,000 cells per second.
In-situ, high temperature x-ray stress determination in patterned, passivated Al interconnects (1994)

As feature size enters the sub‐micron range in Si based solid‐state electronic devices, void formation leading to open circuits in Al interconnect metallizations becomes an increasingly important reliability problem. Techniques for the fast determination of stress in Al thin films in the presence of SiO2 passivation or line patterning were developed and were used to investigate triaxial and biaxial stress states. Stresses were determined as a function of temperature (from 30 °C to 400 °C) with average heating rates on the order of 5 °C/min and with data points every 15–20 °C. Results from a number of 0.6 μm Al(1%Cu)‐film systems are presented, including: blanket unpassivated films; blanket, SiO2 passivated films; passivated, patterned lines with widths ranging from 0.5 to 6.0 μm.
Successful treatment of complex coronary chronic total occlusions improves midterm outcomes (2019)

Among patients with CTOs, high J-CTO score was independently associated with worse clinical outcomes. Furthermore, successful PCI was associated with a lower risk of midterm MACE compared with failed revascularization of CTOs.
The {110} reflection in X‐ray diffraction of <scp>MX</scp> ene films: Misinterpretation and measurement via non‐standard orientation (2017)

Abstract It has been claimed that disappearance of the {110} reflection in powder X‐ray diffraction of MX ene films and powders is indicative of shearing or general disorder of restacking of the flakes. Here we show this to be incorrect and provide experimental justification. The disappearance of this peak arises from a combination of sample texture and orientation. Furthermore, our methods provide a simple way to estimate a unit cell parameters when the relevant reflections are not present in most reports of MX ene films.
Snapshot imprinting: rapid identification of cancer cell surface proteins and epitopes using molecularly imprinted polymers (2021)

Proteomic mapping of cell surfaces is an invaluable tool for drug development and clinical diagnostics. This work describes a new ‘snapshot imprinting’ method designed to obtain proteomic maps of cell surfaces, with the aim of identifying cell surface markers and epitopes for diagnostic and therapeutic applications. The analysis of two cancer cell lines, HN5 and MDA-MB-468, is described herein as a proof of concept, along with the selective targeting of three identified epitopes of epidermal growth factor receptor using molecularly imprinted polymer nanoparticles. 438 proteins were identified using this technique, with 283 considered to be transmembrane or extracellular proteins. The major advantage of the molecular imprinting approach developed here is the ability to analyse cell surface proteins without tedious fractionation, affinity separation or labelling. We believe that this system of protein analysis may provide a basic molecular diagnostics toolbox for precise, personalised treatment of cancer and other diseases.
A MC‐based anthropomorphic test case for commissioning model‐based dose calculation in interstitial breast 192‐Ir HDR brachytherapy (2023)

The dataset facilitates the commissioning of brachytherapy MBDCAs using TPS embedded tools and establishes a methodology for the development of future clinical test cases. It is also useful to non-MBDCA adopters for intercomparing MBDCAs and exploring their benefits and limitations, as well as to brachytherapy researchers in need of a dosimetric and/or a DICOM RT information parsing benchmark. Limitations include specificity in terms of radionuclide, source model, clinical scenario, and MBDCA version used for its preparation.
Analytical Study of Annular-Ring Microstrip Antennas Shorted With Thin Wires (2014)

A new theoretical analysis method is presented for annular-ring microstrip antennas with a short-circuited wall implemented as an array of thin cylindrical wires. Assuming wire spacing to be small compared to wavelength, the averaged boundary conditions are employed. An explicit characteristic equation, which determines resonant frequencies depending on wire spacing and radius is derived. A calculation technique for antenna input impedance is presented. Obtained results show good agreement between theoretical and experimental data. It is shown that the wire short-circuited wall can bring considerably different resonant properties compared to continuous metallic one.
Direkte generative Fertigung von Schmiedegesenken eröffnet neue Möglichkeiten (2010)

RTejournal - Forum fur Rapid Technologie, Vol. 7, Iss. 1 - Umformwerkzeuge sind eine neue und bislang nicht erforschte Anwendung generativ gefertigter Werkzeuge. Der Vortrag prasentiert ein Fallbeispiel, bei dem ein typisches Schmiedeteil mit recht komplexer Geometrie erfolgreich unter Verwendung eines generativ gefertigten Schmiedegesenks hergestellt werden konnte. Die Marktanforderungen zur fruhestmoglichen Verfugbarkeit echter Schmiedeteile werden dargestellt. Die gesamte Prozesskette von der 3D-CAD-Werkzeugkonstruktion uber die Schmiedeprozesssimulation, das Laserstrahlschmelzen der Gesenkeinsatze und die Gesenkmontage bis hin zu den eigentlichen Schmiedeversuchen unter produktionsahnlichen Bedingungen wird dargestellt und mit konventioneller Schmiedegesenkkonstruktion und ‑fertigung verglichen. Die Vorteile und Besonderheiten der generativen Prozesskette werden herausgestellt. Die gefertigten Schmiedeteile werden hinsichtlich Formfullung, Mashaltigkeit und Gefuge mit konventionell geschmiedeten Teilen verglichen. Die Lieferzeit der generativ gefertigten Schmiedegesenke wird der von konventionell hergestellten gegenubergestellt, ebenso die Kosten, um die Vorteile des Einsatzes generativer Fertigung herauszustellen. Es werden Randbedingungen beschrieben, unter denen die generative Fertigung von Schmiedegesenken technisch und wirtschaftlich sinnvoll ist.
Spin-Optical Metamaterial Route to Spin-Controlled Photonics (2013)

Spin optics provides a route to control light, whereby the photon helicity (spin angular momentum) degeneracy is removed due to a geometric gradient onto a metasurface. The alliance of spin optics and metamaterials offers the dispersion engineering of a structured matter in a polarization helicity-dependent manner. We show that polarization-controlled optical modes of metamaterials arise where the spatial inversion symmetry is violated. The emerged spin-split dispersion of spontaneous emission originates from the spin-orbit interaction of light, generating a selection rule based on symmetry restrictions in a spin-optical metamaterial. The inversion asymmetric metasurface is obtained via anisotropic optical antenna patterns. This type of metamaterial provides a route for spin-controlled nanophotonic applications based on the design of the metasurface symmetry properties.
Two-delay robust digital control and its applications-avoiding the problem on unstable limiting zeros (1990)

In the design of linear control systems, the existence of unstable zeros makes it difficult to construct many control systems. When the usual digital control scheme is used, unstable zeros appear in the discrete-time model due to the existence of limiting zeros even though the continuous-time plant is minimal phase. To avoid this unstable zero problem, two new digital control schemes, called two-delay output control and two-delay input control, are proposed. These control systems are proved to have no finite zeros. Asymptotic inverse systems, pole assignable unknown input observers, and output feedback controllers having the LTR (loop transfer recovery) property are developed using the two-delay output control. Zero assignable control systems and model matching control systems are developed using the two-delay input control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Prevalence of Iron Deficiency Anemia in Hemodialysis patients at NIKD (2021)

Background: Iron deficiency is a cause of anemia in many hemodialysis patients. It remains under diagnosed in patients with kidney diseas and it leads to inappropriate response to erythropoietin. Early diagnosis of this anemia before usage of erythropoietin is important, to prevent prescription of expensive erythropoietin and unnecessary costs to the patient and the health care system. This study was conducted to determine prevalence of iron deficiency anemia in hemodialysis patients. Methods: This study was cross-sectional comparative study and was conducted at National Institute of Kidney Disease. Sheikh Zayed hospital nephrology department after taking permission from concerned department. Informed consent was taken from patients also. We measured serum ferritin, serum iron, Total iron binding capacity, complete blood count, hemoglobin in 140 hemodialysis patients. Serum samples were taken, processed and assessed for ferritin levels using commercially available ELISA kits. P value less than ≤ 0.05 was considered statistically significant. Results: Out of 140 hemodialysis patients, 34 had Iron deficiency anemia . (IDA). Conclusion: Iron deficiency anemia was observed in 24.2 % of hemodialysis patients
The Pragmatic Web: Agent-Based Multimodal Web Interaction with no Browser in Sight. (2003)

To a large degree information has become accessible – anytime, anywhere – but not necessarily useful. Unless the right information is presented at the right time, in the right place, and the right way information may simply become unwelcome noise. The Pragmatic Web is about giving control to information consumers so they can customize how to use information. The original Web – The Syntactic Web – has given most of the control to the information producers but, aside of trivial font and plug-in options, has provided little control to information consumers. The Semantic Web better separates content from presentation but has not yet received general acceptance and lacks end-user customization tools. The Pragmatic Web – presented here – is about providing control to information consuming end-users by enabling them to express computationally how to turn existing information into personally relevant information.
Natural Language Processing in Customer Service: A Systematic Review (2022)

Artificial intelligence and natural language processing (NLP) are increasingly being used in customer service to interact with users and answer their questions. The goal of this systematic review is to examine existing research on the use of NLP technology in customer service, including the research domain, applications, datasets used, and evaluation methods. The review also looks at the future direction of the field and any significant limitations. The review covers the time period from 2015 to 2022 and includes papers from five major scientific databases. Chatbots and question-answering systems were found to be used in 10 main fields, with the most common use in general, social networking, and e-commerce areas. Twitter was the second most commonly used dataset, with most research also using their own original datasets. Accuracy, precision, recall, and F1 were the most common evaluation methods. Future work aims to improve the performance and understanding of user behavior and emotions, and address limitations such as the volume, diversity, and quality of datasets. This review includes research on different spoken languages and models and techniques.
Involvement of thioredoxin in the regulation of growth hormone secretion in rat pituitary cell cultures (2001)

We report here an examination of the effect of thioredoxin (TRX) on the secretion of growth hormone (GH) from rat anterior pituitary cells in vitro. Treatment of rat pituitary cells with growth hormone-releasing factor (GRF), but not GH, led to a significant increase in intracellular TRX protein levels. GRF, recombinant human TRX (rhTRX), and a combination thereof were all shown to induce immediate GH secretion from pituitary cells, as evidenced by perifusion experiments. RhTRX, but not other reducing agents such as beta-mercaptoethanol and N-acetyl-L-cysteine, augmented GRF-stimulated and -unstimulated GH secretion from rat pituitary cells in a dose-dependent manner. RhTRX did not significantly affect the GH mRNA expression of pituitary cells stimulated in the presence or absence of GRF. In addition, rhTRX-augmented GH secretion was not significantly affected by the presence of cycloheximide. Collectively, these findings suggest that TRX is induced by stimulation with GRF and plays a regulatory role in GH secretion from rat anterior pituitary cells by enhancing the secretion of stored GH, rather than by the synthesis of GH.
Neurobiology of resilience (2011)

Resilience is commonly conceptualized as the ability to adapt and thrive despite experiencing adversity (Masten et al., 1995; Elder, 1998; Masten & Coatsworth, 1998). A resilient individual has been tested (Rutter, 2006) and continues to demonstrate healthy psychological and physiological stress responses (McEwen, 2003; Charney, 2004). For most, it is possible to conjure an image of such a person: a woman who chooses to work with sexual assault survivors after she herself is raped; a child growing up in poverty who earns a scholarship to college; a hurricane survivor who rebuilds her own home and helps to revitalize her community.
AlGaAs/GaAs HBTs for 10-Gb/s ICs using a new base ohmic contact fabrication process (1993)

A new basic ohmic contact technology for AlGaAs/GaAs heterojunction bipolar transistors (HBTs) is presented. The effect of the device parameters on the high-frequency performance of HBT ICs for 10-Gb/s systems is analyzed, and it is shown that, at a cutoff frequency (f/sub T/) of 40 GHz or more, reducing base resistance or collector capacitance is more effective than increasing f/sub T/ for obtaining high-frequency performance. A process is developed for fabricating base electrodes with a very low ohmic contact resistivity, approximately 10/sup -7/ Omega -cm/sup 2/, by using a AuZn/Mo/Au alloy, which provides the required high performance. Self-aligned AlGaAs/GaAs HBTs, with a 2.5- mu m*5- mu m emitter, using a AuZn/Mo/Au alloy base metal and an undoped GaAs collector, are shown to have an f/sub T/ and a maximum oscillation frequency of about 45 and 70 GHz, respectively, at 3.5 mA. An AGC amplifier with a 20-dB gain and a bandwidth of 13.7 GHz demonstrates stable performance.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>