gebhart/patrepeval huggingface dataset:
B lymphocytes in humans express ZAP‐70 when activated <i>in vivo</i> (2006)

ZAP-70 is a protein tyrosine kinase initially found in T and NK cells. Recently, this important signaling element was detected in leukemic B cells from a subgroup of patients with B cell chronic lymphocytic leukemia (B-CLL). In this study, ZAP-70 was detected in normal B cells from human tonsils, but not from peripheral blood. The cDNA sequence of B cell ZAP-70 was the same as that in T cells. Germinal center B cells and plasma cells had a substantial proportion of ZAP-70+ cells, while memory and follicular mantle B cells, which contain low numbers of activated B cells, expressed relatively little ZAP-70. A cell fraction of IgD+, CD38+ B cells, which are comprised of many in vivo activated B cells, exhibited the highest levels of ZAP-70. Density gradient fractionation of tonsil B cells confirmed that ZAP-70 was not expressed by resting B cells, but was expressed by buoyant, in vivo activated B cells. In these B cells, the expression of ZAP-70 correlated with that of CD38 and not with that of CD5, a hallmark of B-CLL cells. B-CLL cells are activated cells and their ZAP-70 expression reflects a normal property of activated B cells populations rather than a neoplastic aberration.
Coherent control of extreme uv absorption and photoemission by the simultaneous irradiation of ultrashort extreme uv and laser pulses (2002)

We present a theoretical study on the response of a hydrogen atom to the simultaneous irradiation of ultrashort extreme ultraviolet (xuv) and laser pulses. The calculation is based on the time-dependent Schr\"odinger equation. The xuv photon energy is chosen to induce the $1s\ensuremath{-}2p$ transition. Our results indicate that we can transiently reduce the xuv absorption and change the atomic state within a few femtoseconds by injecting a femtosecond laser pulse. The laser-induced photoemission is affected by the addition of an xuv pulse and its yield depends much on the temporal overlap of the two pulses.
Development of multifield three‐dimensional conformal radiotherapy of lung cancer using a total lung dose/volume histogram (1995)

Abstract A measurable improvement in the efficacy of the three‐dimensional radiotherapy (RT) of primary lung cancer patients with unresectable disease will require the development of a technique that increases the therapeutic ratio of dose delivered to the tumor volume relative to functional lung. A full course of definitive RT dose was delivered to six consecutive primary lung cancer patients using multiple fields with treatment portals tightly conformed to the tumor shape in beams‐eye‐view, using multileaf collimation. For each patient, a treatment planning dose/volume histogram (DVH) was constructed considering the most anatomically normal tissues in both the ipsilateral and contralateral lungs. When compared to a standard anteroposterior‐posteroanterior (AP‐PA) treatment plan followed by parallel‐opposed oblique fields with conventional blocks, the five‐field conformal technique yielded a significantly lower integral lung dose as determined by cumulative DVH data. We compared the data for total lung capacity in cubic centimeters from the treatment planning DVH with that obtained by pulmonary function tests and found good concordance. The present RT technique and patient evaluation program should provide a valuable approach toward improving the quality of life in irradiated lung cancer patients, and may also guide efforts by which to escalate the dose to a tumor volume in the chest. © 1995 Wiley‐Liss, Inc.
EphB1-mediated Cell Migration Requires the Phosphorylation of Paxillin at Tyr-31/Tyr-118 (2004)

Interactions between Eph receptors and their membrane-bound ligands (ephrins) are of critical importance for key developmental processes such as boundary formation or vascular development. Their downstream signaling pathways are intricate and heterogeneous at several levels, the combined effect being a highly complex and flexible system. Here we demonstrate that activated EphB1 induces tyrosine phosphorylation of the focal adhesion protein paxillin at Tyr-31 and Tyr-118 and is recruited to paxillin-focal adhesion kinase (FAK) complexes. Pretreatment with the specific Src inhibitor PP2, or expression of dominant-negative, kinase-dead c-Src abrogates EphB1-induced tyrosine phosphorylation of paxillin. Cells transfected with the paxillin mutant Y31F/Y118F displayed a reduced migration in response to ephrin B2 stimulation. Furthermore, expression of an LD4 deletion mutant (paxillin DeltaLD4) significantly reduces EphB1-paxillin association, paxillin tyrosine phosphorylation, as well as EphB1-dependent cell migration. Finally, mutation of the Nck-binding site of EphB1 (Y594F) interrupts the interaction between Nck, paxillin, and EphB1. These data suggest a model in which ligand-activated EphB1 forms a signaling complex with Nck, paxillin, and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c-Src-dependent manner to promote cell migration.
Supplementary Figure 6 from Vulnerabilities of &lt;i&gt;PTEN&lt;/i&gt;–&lt;i&gt;TP53&lt;/i&gt;-Deficient Prostate Cancers to Compound PARP–PI3K Inhibition (2023)

&lt;p&gt;PDF - 69095K, Supporting histology for the in vivo treatment of Olaparib and BKM120.&lt;/p&gt;
An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL (2016)

Diffuse large B-cell lymphomas (DLBCLs) contain 2 major molecular subtypes; namely, the germinal center B-cell-like (GCB) and the activated B-cell-like (ABC) DLBCLs. It is well documented that ABC-DLBCL cases have a significantly poorer survival response than GCB-DLBCLs in both the CHOP (cyclophosphamide, vincristine, doxorubicin, and prednisone) and the rituximab (R)-CHOP eras. However, the underlying cause of this subtype disparity is poorly understood. Nevertheless, these clinical observations raise the possibility for an ABC-DLBCL-specific resistance mechanism that is directed toward 1 of the CHOP components and is inadequately addressed by rituximab. Here, we report that the main cytotoxic ingredient in CHOP, doxorubicin (Dox), has subtype-specific mechanisms of cytotoxicity in DLBCLs resulting from differences in the subcellular distribution pattern. Specifically, in cell line models of ABC-DLBCL, Dox is often enriched in the cytoplasm away from the nuclear DNA. As a result, Dox-induced cytotoxicity in ABC-DLBCLs is often dependent on oxidative stress, rather than DNA damage response. These findings are corroborated by gene signature analysis, which demonstrates that basal oxidative stress status predicts treatment outcome among patients with ABC-DLBCL, but not patients with GCB-DLBCL. In terms of redox-related resistance mechanism, our results suggest that STAT3 confers Dox resistance in ABC-DLBCLs by reinforcing an antioxidant program featuring upregulation of the SOD2 gene. Furthermore, a small-molecule STAT3 inhibitor synergizes with CHOP to trigger oxidative stress and kill ABC-DLBCL cells in preclinical models. These results provide a mechanistic basis for development of novel therapies that target either STAT3 or redox homeostasis to improve treatment outcomes for ABC-DLBCLs.
A study of deployable center-fed reflectarray antenna (2021)

In this paper a deployable center-fed reflectarray antenna for mobile satellite communication systems is proposed. The proposed antenna consists of a main-substrate, four foldable sub-substrates, and a backfire antenna. This antenna can speedily be installed by attaching the backfire antenna and deploying the folded sub-substrates. The design results show that the antenna can satisfy the target gain by adjusting the deployment angle of the sub-substrates. In addition, the validity of the design is verified by measurements.
The Simultaneous Isolation of RNA and DNA from Tissues and Cultured Cells (2003)

Many techniques are currently available that allow the isolation of DNA (1–7) or RNA (8–23), but such methods allow only the purification of one type of nucleic acid at the expense of the other. Frequently, when cellular material is limiting, it is desirable to isolate both RNA and DNA from the same source. Such is the case for biopsy specimens, primary cell lines, or manipulated embryonic stem cells.
Towards a Self-Learning Assistive Vocal Interface: Vocabulary and Grammar Learning (2012)

This paper introduces research within the ALADIN project, which aims to develop an assistive vocal interface for people with a physical impairment. In contrast to existing approaches, the vocal interface is self-learning, which means it can be used with any language, dialect, vocabulary and grammar. This paper describes the overall learning framework, and the two components that will provide vocabulary learning and grammar induction. In addition, the paper describes encouraging results of early implementations of these vocabulary and grammar learning components, applied to recorded sessions of a vocally guided card game, Patience. 1
<i>Fusarium</i> Species Recovered from Waste Peanuts Associated with Sandhill Crane Mortality (1990)

Approximately 5000 sandhill cranes (Grus Canadensis) died from undetermined causes in Gaines County, Texas, in 1985, and an additional 200 died in 1986. Prominent clinical signs were the inability of many sick cranes to hold their necks horizontal and the neck, head, and legs sometimes drooped perpendicularly during flight. Approximately 95% of the dead cranes' gizzards contained peanuts. Culturing of peanuts, shells, soil, and soil debris from fields in which sandhill cranes died showed that Fusarium species were the fungi most frequently isolated and eight species were recovered from these substrates. Fusarium compactum, F. solani, and F. equiseti were the only species recovered from all substrates cultured from both fields.
Quantitation of Cerebral Atrophy due to Normal Aging: Principal Component Analysis with MR Images in Patients’ Age Groups (2018)

To evaluate the degree of cerebral atrophy, quantification methods of a difference from a standard normal brain are often used in clinical practice. However, these methods may not evaluate the cerebral atrophy accurately, because they do not take into account any cerebral atrophies due to normal aging. The purpose of this study is to develop a model for taking into account the cerebral atrophy due to normal aging. We obtained 60 normal magnetic resonance (MR) images from the Alzheimer's disease neuroimaging initiative database. These data included 20 images of each age group of 60's, 70's, and 80's, respectively. For anatomical standardization of the images, we used the statistical parametric mapping software and employed a linear grayscale transformation. The principal component (PC) analysis with voxel values of 60 normal MR images was subsequently performed to calculate eigenvectors and PC scores. All cases were projected onto the eigenspace formed by 2<sup>nd</sup> and 5<sup>th</sup> PC scores. The experimental result showed separated distributions corresponding to the age groups. In addition, the sites of cerebral atrophy could be recognized by displaying eigenimages. Our proposed method would be useful for the accurate evaluation of cerebral atrophy caused by Alzheimer's disease.
Synthesis and conformation of 2-[[3-(1-hydroxyhexyl)phenoxy]methyl]quinoline, a 5-lipoxygenase inhibitor and leukotriene antagonist (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and conformation of 2-[[3-(1-hydroxyhexyl)phenoxy]methyl]quinoline, a 5-lipoxygenase inhibitor and leukotriene antagonistJames D. White, Kraig M. Yager, and Frank StappenbeckCite this: J. Org. Chem. 1993, 58, 12, 3466–3468Publication Date (Print):June 1, 1993Publication History Published online1 May 2002Published inissue 1 June 1993https://pubs.acs.org/doi/10.1021/jo00064a043https://doi.org/10.1021/jo00064a043research-articleACS PublicationsRequest reuse permissionsArticle Views485Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Peak Width at Half Height (In Chromatography), Wh (2019)

Recommendations are given concerning the terminology of methods of separation in analytical chemistry, including chromatography, electromigration techniques, and field-flow fractionation and related techniques.
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors (2016)

Little is known about how pro-obesity diets regulate tissue stem and progenitor cell function. Here we find that high fat diet (HFD)-induced obesity augments the numbers and function of Lgr5[superscript +] intestinal stem-cells (ISCs) of the mammalian intestine. Mechanistically, HFD induces a robust peroxisome proliferator-activated receptor delta (PPAR-d) signature in intestinal stem and (nonISC) progenitor cells, and pharmacologic activation of PPAR-d recapitulates the effects of a HFD on these cells. Like a HFD, ex vivo treatment of intestinal organoid cultures with fatty acid constituents of the HFD enhances the self-renewal potential of these organoid bodies in a PPAR-d dependent manner. Interestingly, HFD- and agonist-activated PPAR-d signaling endow organoidinitiating capacity to progenitors, and enforced PPAR-d signaling permits these progenitors to form in vivo tumors upon loss of the tumor suppressor Apc. These findings highlight how dietmodulated PPAR-d activation alters not only the function of intestinal stem and progenitor cells, but also their capacity to initiate tumors.
An efficient formal synthesis of d,l-mesembrine via a .beta.-(methoxy(phenylthio)methylidene) enolate Robinson annulation sequence (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTAn efficient formal synthesis of d,l-mesembrine via a .beta.-(methoxy(phenylthio)methylidene) enolate Robinson annulation sequenceSteven Hackett and Tom LivinghouseCite this: J. Org. Chem. 1986, 51, 9, 1629–1631Publication Date (Print):May 1, 1986Publication History Published online1 May 2002Published inissue 1 May 1986https://doi.org/10.1021/jo00359a057RIGHTS & PERMISSIONSArticle Views194Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (416 KB) Get e-Alerts Get e-Alerts
Aldehyde Recognition and Discrimination by Mammalian Odorant Receptors via Functional Group-Specific Hydration Chemistry (2014)

The mammalian odorant receptors (ORs) form a chemical-detecting interface between the atmosphere and the nervous system. This large gene family is composed of hundreds of membrane proteins predicted to form as many unique small molecule binding niches within their G-protein coupled receptor (GPCR) framework, but very little is known about the molecular recognition strategies they use to bind and discriminate between small molecule odorants. Using rationally designed synthetic analogs of a typical aliphatic aldehyde, we report evidence that among the ORs showing specificity for the aldehyde functional group, a significant percentage detect the aldehyde through its ability to react with water to form a 1,1-geminal (gem)-diol. Evidence is presented indicating that the rat OR-I7, an often-studied and modeled OR known to require the aldehyde function of octanal for activation, is likely one of the gem-diol activated receptors. A homology model based on an activated GPCR X-ray structure provides a structural hypothesis for activation of OR-I7 by the gem-diol of octanal.
Annex 3. Specifications for the expert group review (2006)

NATURAL SUBSTANCES IN FRENCH POLYNESIA: A PROMISING SECTOR, BUT STILL VULNERABLE French Polynesia has good potential for exploiting its natural substances, because the remoteness of the islands has resulted in a high rate of endemism and many specific chemotypes. Little use has been made of this biodiversity so far; a few plants are used for particular products – monoi, vanilla, sandalwood, noni and tamanu – and a bare ten utilisation projects are under way for other substances. French Polyne...
Relationship of Treatment-Related Cytopenias and Response to Lenalidomide in Patients With Lower-Risk Myelodysplastic Syndromes (2008)

These findings support the hypothesis that a direct cytotoxic effect of lenalidomide specific to the del(5q) clone may be indicative of a TI response.
[Usefulness of regional cerebral oxygen saturation monitoring in balloon test occlusion]. (2006)

The rSO2 significantly correlated with CBF from SPECT and related with appearance of symptoms. Our results revealed that rSO2 monitoring was useful in BTO, and SPECT could be skipped in some cases to determine the strategies for treatment of IC large aneurysms.
Fundamental aspects to localize self-catalyzed III-V nanowires on silicon (2019)

Compressed zip files includes AFM raw data files, SEM images, Simulation codes.
ChemInform Abstract: DIELS‐ALDER REACTIONS OF S‐VINYL‐S‐ARYLSULFOXIMINES (1984)

Abstract Die Oxidation der Sulfilimine (II) liefert die Oxidationsprodukte (III); (lila) wird mit Triethylamin zu (IV) gespalten.
X-ray Linear Dichroism Microscopy of Crystalline Short Chain Alkanes and Semi-crystalline Polyethylene Thin Films (2004)

Extended abstract of a paper presented at Microscopy and Microanalysis 2004 in Savannah, Georgia, USA, August 1–5, 2004.
Interfacial Phenomena of Newspaper Fiber-Reinforced Polypropylene Composite, Part I: The Development of Interfacial Interaction (2003)

In the process of developing interfacial interaction between newspaper fiber (NPF) and polypropylene (PP) by an intensive mixing, the morphological and microstructural characteristics which influence the mechanical behavior of the mixture were investigated by means of a scanning electron microscope (SEM) and a rheometer. The effects of mixing temperature and moisture content in the NPF on the mechanical behavior were elucidated. The development of interfacial interaction took place in two stages, in which the first stage took place over a relatively short time. In this stage, the fiber was not uniformly dispersed in the melted PP matrix. A fully developed interfacial interaction was not developed until the second stage. In this stage, the fiber was uniformly dispersed into the matrix and coated with PP. The mechanical strength of the composite was maximized in the second stage of mixing.
Genetic Deficiency of Acylation Stimulating Protein (ASP(C3ades-Arg)) Does Not Cause Hyperapobetalipoproteinemia in Mice (1999)

The acylation stimulating protein (ASP) is a 76-amino acid peptide that has been proposed as a potent mediator of triglyceride synthesis and, when functionally impaired, as a major cause of hyperapobetalipoproteinemia (HyperapoB). Purification and sequence analysis of ASP from human sera have revealed that ASP is identical to the complement C3-derived activation peptide C3ades-Arg. Because C3 is the precursor for C3ades-Arg and therefore ASP, a deficiency in C3 would be predicted to result in a phenotype characteristic of HyperapoB. To test this hypothesis in vivo, the current study was undertaken in which ASP(C3ades-Arg)-deficient mice were used as a model system. No significant differences were found in the triglyceride, cholesterol, or free fatty acid concentrations in the plasma of fasted normal and ASP(C3ades-Arg)-deficient animals. In addition, plasma lipoprotein analyses indicated that the very low density lipoprotein, low density lipoprotein, and high density lipoprotein cholesterol and triglyceride concentrations as well as the apolipoprotein B-48 and B-100 levels were not significantly different in the plasma of ASP(C3ades-Arg)-deficient and wild type mice. Furthermore, when challenged with an oral fat load, the ASP(C3ades-Arg)-deficient mice showed no impaired ability to clear triglycerides and free fatty acids from their circulation when compared with their wild-type littermates. Collectively, these results indicate that ASP(C3ades-Arg) deficiency does not cause HyperapoB in mice and that the physiological importance of impaired ASP(C3ades-Arg) function as a cause of hyperapobetalipoproteinemia needs to be reevaluated.
VIBRATION OF TALL BUILDIND DUE TO STRONG EARTHQUAKE : Part 1, Numerical Analysis Method on Response of Building (1964)

Authors studied a method of response analysis on the tall buildings, whose structure are space frame, due to strong earthquake by using electric digital computer, and completed the programing of this problem for computer. They checked on the accuracy of this numerical analysis and obtained the conclusion as follows; I) About the time interval of one step of calculation, that is computed by method of step by step, &lrtri;T=0.01 see. is adequate. II) The accuracy of the time of earthquake accelerogram is effective to the result of this response analysis on the building.
Transfection of α(1,3)fucosyltransferase antisense sequences impairs the proliferative and tumorigenic ability of human colon carcinoma cells (2000)

Sialyl Lewis x and sialyl Lewis a are oncodevelopmental antigens involved in the pathogenesis of colon adenocarcinoma. Biosynthesis of these glycans is controlled by α(1,3/1,4)fucosyltransferases. We report the disruption of sialyl Lewis x/a biosynthesis and inhibition of colon carcinoma cell proliferation by stable transfection of antisense sequences directed at the human Lewis α(1,3/1,4)fucosyltransferase gene, FUT3, and the plasma α(1,3)fucosyltransferase gene, FUT6. COLO-205 cells expressed high levels of sialyl Lewis x/a, α(1,3)fucosyltransferase activity, and FUT3/6 transcripts, but COLO</205–derived antisense transfectant cell lines AS5C and AS7A did not. Sense transfectant S6G expressed higher levels of fucosyltransferase than parental COLO-205. Cellular proliferation assays showed marked correlative decreases in the growth of antisense lines and, conversely, increased growth of sense transfectants. Subcutaneous tumors created by injection of nude mice with antisense transfectant cell lines grew more slowly than those arising from control COLO-205 and sense transfectants. These results provide target validation for inhibition of carcinoma proliferation with antisense sequences directed at human fucosyltransferases. Mol. Carcinog. 27:280–288, 2000. © 2000 Wiley-Liss, Inc.