gebhart/patrepeval huggingface dataset:
Léčba plicní arteriální hypertenze (2014)

Plicni hypertenze (PH) je definovana jako abnormalni vzestup krevniho tlaku v plicnici, tedy hodnota středniho tlaku v plicnici (mPAP) 
≥ 25 mmHg. Může se vyskytovat při vlastnim postiženi plicnich cev jako plicni arterialni hypertenze (PAH) ci v ramci sekundarni přiciny 
v důsledku chronickeho srdecniho selhani, respiracniho onemocněni ci jiných přicin. PAH je způsobena zvýsenim plicni cevni rezistence 
(prekapilarni forma PH) se zvýsenim tlaku v plicnici a normalnim tlakem v leve sini nebo v zakliněni. Soucasna farmakoterapie PAH zahrnuje 
blokatory kalciových kanalů, prostanoidy, inhibitory fosfodiesterazy 5, antagonisty endotelinových receptorů. Pouze nemocni 
s pozitivnim testem akutni vazoreaktivity jsou indikovani k lecbě vysokými davkami blokatorů kalciových kanalů. V připadě negativniho 
testu vazoreaktivity je indikovana moderni terapie.
Endovascular Repair of Traumatic Aortic Injury Using a Custom Fenestrated Endograft to Preserve the Left Subclavian Artery (2011)

Left SCA coverage is often required for successful endovascular repair of BAI. A subgroup of patients who undergo left SCA coverage will require revascularization. The use of custom fenestrated endografts for preserving left SCA during thoracic endovascular aortic repair (TEVAR) for BAI is an innovative and feasible option in patients who require revascularization.
Erratum : Quality of initial anticoagulant treatment and risk of CTEPH after acute pulmonary embolism (PLoS ONE (2020) 15: 4 (e0232354) DOI: 10.1371/journal.pone.0232354) (2020)

The second author's initials and the seventh author's initials are indexed incorrectly in PubMed. The correct initials for the second author are: van Rein N. The correct initials for the seventh author are: van der Meer FJM. The second author's initials also appear incorrectly in the citation. The correct citation is: Boon GJAM, van Rein N, Bogaard HJ, Ende-Verhaar YM, Huisman MV, Kroft LJM, et al. (2020) Quality of initial anticoagulant treatment and risk of CTEPH after acute pulmonary embolism. PLoS ONE 15(4): e0232354. https://doi.org/10.1371/journal.pone.0232354.
A Portable Miniaturized Metabolic Gas Analysis System (2011)

Previously we proposed construction of a miniaturized metabolic monitor that could be taken aboard the space station to monitor the physiological response of the body in a microgravity environment. The prototype consisted of an on airway non-dispersive infrared (NDIR) CO2 sensor and a luminescence quenching O2 sensor to measure gas concentrations, and differential pressure ports to measure gas flows. Our motivations, prototype design considerations, and initial experiments were presented in a previous paper.1 This paper aims to further examine the efficacy of the prototype device through 1) characterization of the flow profile by using a discharge coefficient, and 2) validation of the oxygen sensor at the high volumetric flows.
Hypervalent iodine-mediated oxidation of alcohols (2009)

Over the past two decades there has been a dramatic increse in the use of hypervalent iodine compounds in synthetic organic chemistry due to their mild and selective oxidizing properties. Hypervalent iodine compounds catalyze various oxidation reactions such as the oxidation of alcohols, alpha-oxidation of ketones, oxidative spirocyclization of phenols, etc. Very recently, we found that 2-iodoxybenzensulfonic acid (IBS, ), which was generated from 2-iodobenzenesulfonic acid in situ, is an extremely active and mild catalyst for the highly chemoselective oxidation of various alcohols with powdered Oxone(R) to carbonyl compounds such as aldehydes, carboxylic acids, ketones and cycloalkenones under non-aqueous conditions. In this review, we focus on the design of hypervalent iodine catalysts and review the discovery and development of the oxidation of alcohols with the stoichiometric or catalytic use of hypervalent iodine compounds.
Guest Editors' Introduction: Managing Uncertainty through Postfabrication Calibration and Repair (2010)

This special issue presents six articles that highlight challenges, and approaches toward improving, design yield and reliability through postsilicon optimizations. The articles cover postsilicon adaptation and repair issues in a wide range of areas including analog circuits, embedded memories, and multicore systems.
Site-specific glycosylation mapping of Fc gamma receptor IIIb from neutrophils of health donors (2020)

ABSTRACT Fc gamma receptors (FcγR) translate antigen-recognition by immunoglobulin G (IgG) into various immune responses. A better understanding of this key element of immunity promises novel insights into mechanisms of (auto-/allo-)immune diseases and more rationally designed antibody-based drugs. Glycosylation on both IgG and FcγR impacts their interaction dramatically. In this study, we developed a straightforward and comprehensive analytical methodology to map FcγRIIIb glycosylation from primary human material. In contrast to recently published alternatives, we assessed all glycosylation sites in a single LC-MS/MS run and simultaneously determined the donor allotype. Studying FcγRIIIb derived from healthy donor neutrophils, we observed profound differences as compared to the soluble variant and the homologous FcγRIIIa on natural killer cells. This method will allow assessment of FcγRIII glycosylation differences between individuals, cell types, subcellular locations and pathophysiological conditions.
Optical Signatures of Coupled Quantum Dots (2006)

An asymmetric pair of coupled InAs quantum dots is tuned into resonance by applying an electric field so that a single hole forms a coherent molecular wave function. The optical spectrum shows a rich pattern of level anticrossings and crossings that can be understood as a superposition of charge and spin configurations of the two dots. Coulomb interactions shift the molecular resonance of the optically excited state (charged exciton) with respect to the ground state (single charge), enabling light-induced coupling of the quantum dots. This result demonstrates the possibility of optically coupling quantum dots for application in quantum information processing.
Facilitated transport liquid membrane separations for the gas industry. Final report Feb 82-Jan 83 (1983)

This report discusses a fundamental research to provide the basis for a new gas separation process, facilitated transport liquid membranes, which has the potential to overcome the selectivity problems inherent in conventional membrane separation processes and to investigate the mechanism for facilitated transport, the relationship between mass transport and system properties, and evaluate degradation problems in liquid membrane systems.
Use of Twin Screw Extruders as a Process Chemistry Tool: Application of Mechanochemistry To Support Early Development Programs (2018)

GS-X and GS-Y are novel active pharmaceutical ingredients (APIs) selected for early clinical development. For each API, two slightly hygroscopic unsolvated polymorphs were identified, and investigations of these phases were required to identify the stable form at room temperature. To support this, twin screw extruders were utilized to apply mechanochemistry for scale-up of GS-X and GS-Y polymorphs. The resulting materials were used to conduct solubility measurements to map relative stabilities so that crystallizations could be designed to ensure form control for the thermodynamically most stable form at room temperature.
Metalloenediynes:  Ligand Field Control of Thermal Bergman Cyclization Reactions  [<i>J. Am. Chem. Soc.</i> <b>2000</b>, <i>122</i>, 7208−7217]. (2000)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionMetalloenediynes: Ligand Field Control of Thermal Bergman Cyclization Reactions [J. Am. Chem. Soc.2000, 122, 7208−7217]. Pedro J. Benites, , and Jeffrey M. ZaleskiCite this: J. Am. Chem. Soc. 2000, 122, 40, 9882Publication Date (Web):September 21, 2000Publication History Published online21 September 2000Published inissue 1 October 2000https://pubs.acs.org/doi/10.1021/ja004659ghttps://doi.org/10.1021/ja004659gcorrectionACS PublicationsCopyright © 2000 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views380Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (8 KB) Get e-Alertsclose Get e-Alerts
Status and Trends of SOI (1994)

The evolution of the SOI material, devices and circuit applications is reviewed over the last ten years and demontrates that SOI has now reached a level of maturity which renders it suitable for a number of applications. Low-power, high-temperature, high-performance analog and microwave capabilities of SOI are discussed into further detail.
Genome Mining and Gene Expression Reveal Maytansine Biosynthetic Genes from Endophytic Communities Living inside Gymnosporia heterophylla (Eckl. and Zeyh.) Loes. and the Relationship with the Plant Biosynthetic Gene, Friedelin Synthase (2022)

Even though maytansine was first discovered from Celastraceae plants, it was later proven to be an endophytic bacterial metabolite. However, a pure bacterial culture cannot synthesize maytansine. Therefore, an exclusive interaction between plant and endophytes is required for maytansine production. Unfortunately, our understanding of plant-endophyte interaction is minimal, and critical questions remain. For example: how do endophytes synthesize maytansine inside their plant host, and what is the impact of maytansine production in plant secondary metabolites? Our study aimed to address these questions. We selected <i>Gymnosporia heterophylla</i> as our model and used amino-hydroxybenzoic acid (AHBA) synthase and halogenase genes as biomarkers, as these two genes respond to biosynthesize maytansine. As a result, we found a consortium of seven endophytes involved in maytansine production in <i>G. heterophylla</i>, based on genome mining and gene expression experiments. Subsequently, we evaluated the friedelin synthase (FRS) gene's expression level in response to biosynthesized 20-hydroxymaytenin in the plant. We found that the FRS expression level was elevated and linked with the expression of the maytansine biosynthetic genes. Thus, we achieved our goals and provided new evidence on endophyte-endophyte and plant-endophyte interactions, focusing on maytansine production and its impact on plant metabolite biosynthesis in <i>G. heterophylla</i>.
Moisture Distribution in Fluidized Beds with Liquid Injection (2011)

Abstract Coupled discrete element method‐computational fluid dynamics (DEM‐CFD) simulations have been performed to study the fluid and particle dynamics in a fluidized‐bed granulator on the scale of individual particles. Simulation of the gas and particle dynamics is combined with heat and mass transfer mechanisms, as the moisture distribution is a key parameter for the functionality of a fluidized‐bed spray granulator. The model allows monitoring the moisture content and temperature of each individual particle as well as the temperature and humidity of the surrounding gas phase. A novel modeling approach is presented to describe the process dynamics of a fluidized bed in full detail for a reference time interval using coupled DEM‐CFD simulations. The motion profile of gas and particles is extrapolated to larger time scales and used for the calculation of heat and mass transfer. Through this multiscale approach, a step forward is taken towards a physically based description of the microprocesses in granulation.
Synthesis, physicochemical and catalytic properties of Ni/PrCeZrO catalysts for water-gas shift reaction (2017)

Abstract Mixed nanocrystalline ceria-zirconia oxides doped with praseodymium containing 5, 7.5, 10, and 12.5 wt. % nickel were prepared by the incipient wetness impregnation of the oxide support. Complex physicochemical characterization by X-ray diffraction analysis, ultraviolet-visible diffuse reflectance spectroscopy, high resolution transmission electron microscopy and Fourier-transform infrared spectroscopy of adsorbed CO revealed that the nickelcontaining samples are comprised of a solid solution of praseodymium, cerium and zirconium oxides with the fluorite structure as well as nickel oxide particles with a size up to 100 nm. All prepared nanocomposite catalysts show a high catalytic activity in the water-gas shift reaction. The optimum content of nickel in the catalyst providing the maximum activity was found to be 10 wt. %. A high oxygen mobility in these catalysts estimated by the temperature-programmed oxygen isotope heteroexchange with C18O2 provides required coking stability. To eliminate local overheating of the catalyst and decrease the pressure drop in the reactor, as required for further up-scaling, the active component was supported on a metal plate made of Ni-Al foam alloy. At a fixed contact time, the same level of CO conversion with a fraction of the active component was achieved with an approximately 50 wt% loading on the support.
Atmospheric Refractivity Anomalies Induced by Mesoscale von Kármán Vortex Streets (2013)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text C. G. Nunalee, J. Minet, S. Basu, and M. A. Vorontsov, "Atmospheric Refractivity Anomalies Induced by Mesoscale von Kármán Vortex Streets," in Imaging and Applied Optics, OSA Technical Digest (online) (Optica Publishing Group, 2013), paper PW3F.2. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
P3‐157: A novel microRNA interaction relevant to alzheimer's disease pathogenesis and drug target discovery: miR‐346 induces expression of amyloid precursor protein (2011)

The neuropathological features of Alzheimer's disease (AD) are hypothesized to result from excessive soluble levels of amyloid-ß peptide (Aß), a proteolytic cleavage product of the amyloid precursor protein (APP). Thus, understanding the native regulatory pathways utilized by human cells to control APP expression is essential for identifying novel drug targets central to the Aß-generating process. We have recently reported that microRNA (miRNA), including miR-101, inhibit APP expression by targeting the APP 3'-UTR [Long and Lahiri, BBRC 404 (2011), 889-895]. Delivery of a target protector designed to blockade the interaction between miR-101 and its target site within APP 3'-UTR enhanced APP levels. In contrast to miR-101, here we report miR-346 exhibits non-canonical effects by inducing APP expression through a putative target site in APP 5'-UTR. Bioinformatic tools were used to predict miRNA target sites in human APP 5'-UTR. We utilized a previously described APP 5'-UTR reporter construct (pGAL). MiR-346 mimic was co-transfected into mammalian cells along with the reporter construct to validate target predictions. APP mRNA and protein levels were assessed by RT-qPCR and Western blotting. Target protectors were used to disrupt the interaction between miR-346 and reporter mRNA. Bioinformatic tools successfully predicted a miR-346 target site in APP 5'-UTR. Reporter assays in HeLa cells revealed that miR-346 significantly stimulated reporter expression via APP 5'-UTR. This stimulatory effect on reporter expression was reversed with co-transfection of a target protector designed against the predicted miR-346 target site in APP 5'-UTR. To confirm the effect of miR-346 on native protein expression, miR-346 mimic was transfected into HeLa cells. In response, APP protein levels were dramatically increased relative to controls. This effect was replicated in human astrocytic U373 and rat neuronal-like PC12 cells. APP mRNA levels in HeLa were only slightly increased following miR-346 transfection, suggesting a post-transcriptional mechanism. In a comparison across cell lines, miR-346 levels were highest in CNS-like NT2 neurons as compared to non-neuronal cell lines. Our results reveal a novel, non-canonical regulatory interaction between miR-346 and the APP 5'-UTR mediated primarily through a post-transcriptional mechanism. Therefore, miR-346 may represent a novel drug target in AD.
Patterning of ZnS–SiO<sub>2</sub> by Laser Irradiation and Wet Etching (2006)

Generally, ZnS–SiO2 thin film is used as a protective layer in phase-change optical media. The wet etching characteristics of ZnS–SiO2 have been investigated, and it was found that ZnS–SiO2 can be patterned by laser irradiation and wet etching. Convex patterns of ZnS–SiO2 with steep taper profiles were formed. The minimum size of ZnS–SiO2 dots was 90 nm, and the minimum width of ZnS–SiO2 lines was 100 nm. These pattern sizes were approximately one-fourth of the laser beam spot from a 405 nm laser diode (LD) with an objective lens of 0.85 numerical aperture (NA). The pattern edges of ZnS–SiO2 dots and lines were clear and smooth. These results prove that ZnS–SiO2 is a useful material for forming nanometer-scale patterns.
Carbohydrate Moieties of Peanut Agglutinin Receptors Isolated from Human Gastric Cancer Cells1 (1987)

Receptors for peanut agglutinin (PNA) were isolated from Kato III human gastric cancer cells by affinity chromatography on PNA agarose, and were labeled by the galactose oxidase-NaB3H4 method. Alkaline NaBH4 treatment of the labeled receptors released two small oligosaccharide alcohols, which were identified as Gal beta 1----3GalNAc-ol and Gal beta 1----4GlcNAc beta 1----6(Gal beta 1----3)GalNAc-ol. Higher oligosaccharides and glycopeptides of both N- and O-linked type were also detected, but they did not appear to bear PNA binding sites. The presence of oligo-N-acetyllactosamine units in the N-linked type sugars was indicated by endo-beta-galactosidase digestion.
Protorphyrinogen oxidase inhibition by three peroxidizing herbicides : oxadiazon , LS 82-556 and M and B 39279 (1989)

International audience
Performance-based metamodel for healthcare facilities (2010)

This paper introduces an organizational model describing the response of the Hospital Emergency Department (ED). The metamodel is able to estimate the hospital capacity and the dynamic response in real time and to incorporate the influence of the damage of structural and non-structural components on the organizational ones. The waiting time is the main parameter of response and it is used to evaluate the disaster resilience index of healthcare facilities. Its behaviour is described using a double exponential function and its parameters are calibrated based on simulated data. The metamodel covers a large range of hospital configurations and takes into account hospital resources, in terms of staff and infrastructures, operational efficiency and existence of an emergency plan, maximum capacity and behaviour both in saturated and over-capacitated conditions. The sensitivity of the model to different arrival rates, hospital configurations, and capacities and the technical and organizational policies applied during and before the strike of the disaster has been investigated. This model becomes an important tool in the decision process either for the engineering profession or for the policy makers. Copyright © 2010 John Wiley & Sons, Ltd.
Retinal Disturbances in Patients and Animal Models with Huntington’s, Parkinson’s and Alzheimer’s Disease (2011)

Huntington’s disease (HD), Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative disorders associated with aging. The main hallmarks of these pathologies are deposits of mutant proteins, mitochondrial dysfunctions, reactive oxygen species (ROS) and neuronal death. These diseases affect from heterogeneous form to different brain regions. In fact, psychophysical, electrophysiological and morphological evidence shows that retinal and higher visual centers disturbances occur in HD, PD and AD. Thus, patients with these disorders suffer contrast sensitivity deficits, altered color vision and damaged conscious and unconscious visual perception. These visual deficiencies may contribute to symptoms of these pathologies related to behavior, memory and difficulty in performing daily tasks such as driving, reading or keeping their balance. This chapter tries to integrate the visual changes in pathogenesis and symptomatology of patients with HD, PD and AD and reviews the recent findings in animal models of these diseases to provide an insight into how retinal changes might contribute to symptoms of HD, PD and AD.
Mosaicplasty Using Grafts From the Upper Tibiofibular Joint (2017)

Autologous mosaicplasty has been widely used for the treatment of focal, full-thickness, articular cartilage lesions of the knee and ankle joints. Commonly, the autografts are harvested from non-weight-bearing areas of the knee joint, leading to associated donor-site morbidity and representing a considerable disadvantage. This Technical Note presents a mosaicplasty procedure for harvesting autologous osteochondral plugs from the upper tibiofibular joint to repair articular cartilage defects. With this technique, it is possible to achieve low or no risk of donor-site morbidity, being therefore a safe and favorable option to treat large cartilage defects. Because of its minimal size-related restrictions, it enables harvesting larger plugs (filling an area up to 5 cm<sup>2</sup>) without any additional iatrogenic complications. Hence, mosaicplasty using the upper tibiofibular joint autografts can overcome many of the reported complications associated with osteochondral autograft harvesting. Thus, the upper tibiofibular joint articular surface should be considered as a safe and reliable autograft source for harvesting osteochondral plugs.
Self-compensation in heavily Ge doped AlGaN: A comparison to Si doping (2021)

Self-compensation in Ge- and Si-doped Al0.3Ga0.7N has been investigated in terms of the formation of III vacancy and donor-vacancy complexes. Both Ge- and Si-doped AlGaN layers showed a compensation knee behavior with impurity compensation (low doping regime), compensation plateau (medium doping regime), and self-compensation (high doping regime). A maximum free carrier concentration of 4–5 × 1019 cm−3 was obtained by Ge doping, whereas Si doping resulted in only half of that value, ∼2 × 1019 cm−3. A DFT calculation with the grand canonical thermodynamics model was developed to support the hypothesis that the difference in self-compensation arises from the difference in the formation energies of the VIII-n•donor complexes relative to their onsite configurations. The model suggested that the VIII-2•donor and VIII-3•donor complexes were responsible for self-compensation for both Ge- and Si-doped AlGaN. However, a lower free carrier concentration in Si-doped samples was due to a high VIII-3•Si concentration, resulting from a lower energy of formation of VIII-3•Si.