gebhart/patrepeval huggingface dataset:
Stability of Human-in-the-Loop Multiagent Systems with Time Delays* This research was supported in part by the Dynamics, Control, and Systems Diagnostics Program of the National Science Foundation under Grants CMMI-1657637. (2019)

We study a group of agents with linear time-invariant (LTI) dynamics commanded by a human operator with a general LTI model and a reaction time-delay. Under remote operation, the human receives time-delayed information from a subset of the agents, and commands, under another time-delay, the same or a different subset of the agents. Stability of this human-in-the-loop multiagent system is next studied both in “time-domain” and “frequency-domain”, specifically to investigate how the system network graph affects the largest delay tolerable before losing stability. In a case study, system stability is shown to hold for larger delays in graphs with fewer edges than in a strongly-connected graph.
ROTATIONAL-PULSE ACTUATED DISSOLVABLE-FILM VALVES FOR AUTOMATED PURIFICATION OF TOTAL RNA FROM E. COLI (2014)

In this work we report for the first time on a repertoire of valving technologies which are combined to enable automated purification of total RNA from cell homogenate. Process control is implemented us-ing rotational-pulse actuated dissolvable-film (DF) valves; where the order of valve actuation is deter-mined by the disc architecture while the timing of valve actuation is governed by pulses in the spin rate. Selective liquid routing is enabled by combining a heavy, inert and immiscible liquid plug with a DF. The combination of these technologies enables bead-based extraction of amplifiable RNA, with a yield comparable to gold-standard bench-top protocols.
IC‐P‐039: Assessment of hippocampal volumetry in transgenic Alzheimer's disease rats (2013)

Volumetric analysis is particularly useful for assessing brain atrophy in aging and neurodegeneration research. While significant methodological efforts were made to systematize hippocampal human volumetry, yet no such work has been done in rodents. We hypothesize that McGill-R-Thy1-APP transgenic rats with have smaller hippocampal volume than wild-type rats. Imaging acquisition consisted of MRI (Brooker 7T) using a Fast Imaging with Steady State Precession (FISP; TR/TE: 3000/9ms; isotropic 250um voxels; 8 angles). WT (N=3; BM=588.6±109.2 g; Age=22 months) and McGill-R-Thy1-APP (N=5; BM=739.3±140.6g; Age=22 months) male rats had MRI scans under 2% Isoflurane anaesthesia. Hippocampal 3D manual volumetry was performed using the software Display. Coronal images of commissural fornix and amygdala set the anterior hippocampal landmarks. Segmentation continued posteriorly until the granular layer and CA1 disappeared. Ventricles and the mesencephalic cistern served as the medial and lateral landmarks, respectively. Subiculum set the inferior and posterior hippocampal limits. Adjustments were guided by the correspondent sagittal and lateral views of the brains. Three repetitive measurements were taken from each rat. The analyzed hippocampal volume was 657.1±33.5 mm 3 for WT and 564.8±6.5 mm 3 for TG (14%, P=0.01). The total brain volume was 3185.4±117.4 mm 3 for WT and 2846.5±96.6 mm 3 for TG (10%; P<0.01). Coefficient of variation (CV) was 8.8% for WT and 2.6% for TG. When corrected for total brain volume, the adjusted hippocampal differences decreased to 4%. Single rater absolute intra-class correlation value of 0.91 and F-value of 32 proved significantly high reproducibility of this manual segmentation method.
Dilazep, an Antiplatelet Agent, Inhibits Tissue Factor Expression in Endothelial Cells and Monocytes (1997)

Dilazep, an antiplatelet agent, is generally used as an antithrombotic drug in clinical practice. Dilazep is also known to exert cytoprotective and antioxidant effects on endothelial cells. However, its effect on the endothelial or monocyte procoagulant activity is unknown. In the current study, the effect of dilazep on the expression of tissue factor (TF) in human umbilical vein endothelial cells (HUVECs) after the stimulation with tumor necrosis factor-alpha (TNF), thrombin, or phorbol 12-myristate 13-acetate (PMA) was evaluated. We also evaluated the effect of dilazep on TNF (1,000 U/mL)-induced TF expression on monocytes. Dilazep inhibited TF activity induced on HUVECs by each stimulant, TNF (1000 U/mL), thrombin (25 nmol/L), or PMA (5 nmol/L) in a dose-dependent fashion (1 to 100 microg/mL). TF activity decreased to approximately 10% after treating with 100 microg/mL of dilazep. Dilazep also blocked the expression of TF antigen induced by each stimulant on the surface of HUVECs as determined by flow cytometric analysis. In addition, in HUVECs, it significantly decreased the expression of TF mRNA and the total TF antigen induced by thrombin or PMA, but not those induced by TNF, suggesting that dilazep blocks the TF expression induced by PMA or thrombin at a transcriptional level and that induced by TNF at a posttranscriptional level. Western blot analysis showed that dilazep reduces the accumulation of native TF but increases that in lower molecular weight TF derivatives. The adenosine receptor antagonist, 8-(p-sulfophenyl) theophylline, partially counteracted the anticoagulant activity of dilazep on HUVECs, thereby suggesting that the inhibitory effect of dilazep on TF expression in HUVECs depends, at least in part, on its adenosine potentiating activity. Dilazep also inhibited TNF-induced TF expression on monocytes in a dose-dependent fashion (0.1 to 100 microg/mL). In brief, the current study showed for the first time that dilazep, a commonly used antiplatelet drug, strongly inhibits the TF expression in HUVECs and monocytes. Dilazep may have a potent therapeutic value in patients with hypercoagulable state for its inhibitory property on the procoagulant activity of endothelial cells and monocytes.
Effect of the introduction of alkaline promoters into chromium oxide catalysts for propane dehydrogenation in the presence of CO2 (2012)

The influence of the introduction of alkaline promoters into chromium oxide catalysts for the dehydrogenation of propane in the presence of CO2 was investigated. The positive role of potassium, which manifested itself in an increase in the selectivity and stability of catalysts, was shown. It was established by IR spectroscopy that, in the chromium oxide catalysts where a substantial part of protons is replaced by an alkaline ion, a decrease in their activity and stability in the dehydrogenation of propane in the presence of CO2 was observed.
Data Compression Concepts and Algorithms and Their Applications to Bioinformatics (2009)

Data compression at its base is concerned with how information is organized in data. Understanding this organization can lead to efficient ways of representing the information and hence data compression. In this paper we review the ways in which ideas and approaches fundamental to the theory and practice of data compression have been used in the area of bioinformatics. We look at how basic theoretical ideas from data compression, such as the notions of entropy, mutual information, and complexity have been used for analyzing biological sequences in order to discover hidden patterns, infer phylogenetic relationships between organisms and study viral populations. Finally, we look at how inferred grammars for biological sequences have been used to uncover structure in biological sequences.
Clinical advances in the understanding, diagnosis, and treatment of epilepsy (2020)

UCL Queen Square Institute of Neurology, London, UK Correspondence to Matthew C. Walker, PhD, UCL Queen Square Institute of Neurology, London, UK. E-mail: [email protected]
A soft frequent pattern mining approach for textual topic detection (2014)

Textual topic detection methods that work by clustering terms according to their cooccurrence patterns are called feature-pivot methods. Typically, the similarity measure that is used for such clustering methods takes into account the cooccurrence patterns of only pairs of items. In this work, we argue that examining the simultaneous cooccurrence patterns of a larger number of terms, is a better option when the corpus contains a set of closely related fine-grained topics. To this end, we treat the topic detection problem as a Frequent Pattern Mining problem and propose a novel algorithm for "soft" Frequent Pattern Mining. We test the proposed approach using three annotated datasets collected from Twitter and compare it to a set of algorithms that includes a graph-based feature-pivot approach that takes into account only cooccurrence patterns, a standard Frequent Pattern Mining algorithm and Latent Dirichlet Allocation. The results indicate that SFPM is performing better than the other tested methods and show a clear improvement over the standard FPM approach.
Cu(II)−Aza(bisoxazoline)-Catalyzed Asymmetric Benzoylations (2005)

[reaction: see text] Racemic 1,2-diols and alpha-hydroxy carbonyl compounds can be asymmetrically benzoylated in a kinetic resolution in the presence of various Cu(II)-aza(bisoxazoline) catalysts. A novel bisbenzyl-substituted aza(bisoxazoline) ligand proved to be especially effective when immobilized on MeOPEG(5000), giving from 91 to > or = 99% ee in 37-49% yield for each of five sequential reactions.
ChemInform Abstract: Practical Os/Cu‐Cocatalyzed Air Oxidation of Allyl and Benzyl Alcohols at Room Temperature and Atmospheric Pressure. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Amélioration de la prise en compte du couplage dans un réseau (2003)

National audience
Genome-wide CRISPR-dCas9 screens in <i>E. coli</i> identify essential genes and phage host factors (2018)

Abstract High-throughput genetic screens are powerful methods to identify genes linked to a given phenotype. The catalytic null mutant of the Cas9 RNA-guided nuclease (dCas9) can be conveniently used to silence genes of interest in a method also known as CRISPRi. Here, we report a genome-wide CRISPR-dCas9 screen using a pool of ~ 92,000 sgRNAs which target random positions in the chromosome of E. coli . We first investigate the utility of this method for the prediction of essential genes and various unusual features in the genome of E. coli . We then apply the screen to discover E. coli genes required by phages λ, T4 and 186 to kill their host. In particular, we show that colanic acid capsule is a barrier to all three phages. Finally, cloning the library on a plasmid that can be packaged by λ enables to identify genes required for the formation of functional λ capsids. This study demonstrates the usefulness and convenience of pooled genome-wide CRISPR-dCas9 screens in bacteria in order to identify genes linked to a given phenotype.
[Boeck's disease with spinal involvement and retroperitoneal fibrosis]. (1979)

Sarcoidosis (Morbus Boeck) is a frequently found disease of the reticulohistiocytic system. Etiology and pathogenesis were mostly unknown until today. Histologic study of sarcoidosis shown granuloma with epitheloid cells similar to tuberculosis, often with hyalinization but without cheesy necrosis. The disease mostly starts with a mediastinal and cervical lymphadenopathy. Radiographically, the disease shows three typical stages when spreading to the lungs. Bone involvement in lymphomas, especially vertebral involvement, is found to be rare. A case with an additional retroperitoneal fibrosis is reported from our own hospital.
Organic Reactions. Volume 75 (Diamond Volume). Herausgegeben von Scott E. Denmark. (2012)

John Wiley & Sons, Hoboken 2011. 880 S., geb., 175.00 $.—ISBN 978-0470889077
Performance analysis of the impulse shift CVT (2004)

Due to rotating inertias within the engine and transmission, the response of a vehicle during large engine speed shifts may appear reluctant or even counteractive. To overcome this behaviour, a CVT drivetrain was augmented with a powersplitting planetary gear stage and steel flywheel in the so-called Zero Inertia (ZI) powertrain [1]. This transmission concept managed to combine two contradictive goals: · the driveability in terms of the pedal-to-wheel response is greatly improved; · and a large leap towards optimal fuel economy can be made. These goals were achieved by cruising the vehicle at extremely low engine speeds, enabled by the large ratiocoverage of the CVT. The flywheel acts as a 'peakshaver' during engine speed transients: it delivers power during (semi-) pedal kickdown and absorbs the engine's kinetic energy at pedal back-out. The current paper presents an improved concept with respect to the Zero Inertia drivetrain, which enables a reduced flywheel size while enhancing the pedal-towheel response even further. This concept is designated the Impulse Shift CVT (IS-CVT). The IS-CVT incorporates a slightly modified drive clutch and uses it to interrupt the power flow through the CVT during kickdown accelerations. Disengaging the drive clutch directs the entire engine power flow through the parallel (flywheel and planetary gear) branch, resulting in an immediate flywheel assist while the engine speeds up rapidly. When the engine has reached its desired speed, the drive clutch is re-engaged and the power flow through the CVT is reinstated. The presented IS-CVT concept enables much faster speed transients, independent of the CVT shift rate, resulting in a more effective use of the flywheel energy. Hence the flywheel can be reduced, and the ZI effect can be exploited to the fullest. Furthermore, the demands on the variator actuators can be lower. Simulations of the performance of the IS-CVT are presented and compared to those of CVT and ZI equipped vehicles.
Channel estimation using short training sequences (2002)

The estimation of the impulse responses of time-variant mobile radio channels is a challenging issue in mobile communication systems. For CDMA systems, it is generally assumed that the receiver knows the corresponding spreading sequences. A maximum likelihood channel estimation method, which uses the known spreading sequences together with short training sequences, is considered for synchronous CDMA systems.
Hexane-1,2,5,6-tetrol as a Versatile and Biobased Building Block for the Synthesis of Sustainable (Chiral) Crystalline Mesoporous Polyboronates (2019)

We report on the synthesis and characterization of novel mesoporous chiral polyboronates obtained by condensation of (<i>R</i>,<i>S</i>)/(<i>S</i>,<i>S</i>)-hexane-1,2,5,6-tetrol (HT) with simple aromatic diboronic acids (e.g., 1,3-benzenediboronic acid) (BDB). HT is a cellulose-derived building block comprising two 1,2-diol structures linked by a flexible ethane bridge. It typically consists of two diastereomers one of which [(<i>S</i>,<i>R</i>)-HT] can be made chirally pure. Boronic acids are abundantly available due to their importance in Suzuki-Miyaura coupling reactions. They are generally considered nontoxic and easy to synthesize. Reactive dissolution of generally sparingly soluble HT with BDB, in only a small amount of solvent, yields the mesoporous HT/polyboronate materials by spontaneous precipitation from the reaction mixture. The 3D nature of HT/polyboronate materials results from the entanglement of individual 1D polymeric chains. The obtained BET surface areas (SAs) and pore volumes (PVs) depend strongly on HT's diastereomeric excess and the meta/para orientation of the boronic acids on the phenyl ring. This suggests a strong influence of the curvature(s) of the 1D polymeric chains on the final materials' properties. Maximum SA and PV values are respectively 90 m<sup>2</sup> g<sup>-1</sup> and 0.44 mL g<sup>-1</sup>. Variably sized mesopores, spanning mainly the 5-50 nm range, are evidenced. The obtained pore volumes rival the ones of some covalent organic frameworks (COFs), yet they are obtained in a less expensive and more benign fashion. Moreover, currently no COFs have been reported with pore diameters in excess of 5 nm. In addition, chiral boron-based COFs have presently not been reported. Scanning electron microscopy reveals the presence of micrometer-sized particles, consisting of aggregates of plates, forming channels and cell-like structures. X-ray diffraction shows the crystalline nature of the material, which depends on the nature of the aromatic diboronic acids and, in the specific case of 1,4-benzenediboronic acid, also on the applied diastereomeric excess in HT.
The Selective Functionalization of Pyridazino[4,5-d]pyridazines Using Polar Organometallic Reagents (2007)

Selected pyridazino[4,5-d]pyridazine derivatives were reacted with polar organometallic reagents to result in the addition of the organic moiety onto the 5-position of the ring system with high selectivity.
The Overdiagnosis of Lyme Disease-Reply (1993)

<h3>In Reply.</h3> —We did not ignore the clinical picture in diagnosing Lyme disease. On the contrary, the patients in our report were required to meet clinical criteria for one or more of the characteristic clinical manifestations of this disorder. We have never claimed that our serologic test for Lyme disease was "better" than those of other laboratories. However, based on the results of testing in our laboratory, 176 of the 180 patients (98%) who met clinical criteria for Lyme disease had serologic evidence of infection with<i>B burgdorferi</i>. Of the 452 patients who did not meet these criteria, none had a positive test result. Thus, in our study, there was a strong correlation between clinical diagnosis and serologic test results. Of the 180 patients with Lyme disease, only four (2%) met clinical criteria for late manifestations of the disorder but had no antibody response to<i>B burgdorferi</i>. Three of these
Heterogeneous clearance rates of long-lived lymphocytes infected with HIV: Intrinsic stability predicts lifelong persistence (2003)

Viral replication and latently infected cellular reservoirs persist in HIV-infected patients achieving undetectable plasma virus levels with potent antiretroviral therapy. We exploited a predictable drug resistance mutation in the HIV reverse transcriptase to label and track cells infected during defined intervals of treatment and to identify cells replenished by ongoing replication. Decay rates of subsets of latently HIV-infected cells paradoxically decreased with time since establishment, reflecting heterogeneous lymphocyte activation and clearance. Residual low-level replication can replenish cellular reservoirs; however, it does not account for prolonged clearance rates in patients without detectable viremia. In patients receiving potent antiretroviral therapy, the latent pool has a heterogeneous and dynamic composition that comprises a progressively increasing proportion of stable lymphocytes. Eradication will not be achieved with complete inhibition of viral replication alone.
ChemInform Abstract: Structure—Activity Relationships Study at the 3′‐N Position of Paclitaxel. Part 1. Synthesis and Biological Evaluation of the 3′‐(t)‐Butylaminocarbonyloxy Bearing Paclitaxel Analogues. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Acyclic Pseudopeptidic Hosts as Molecular Receptors and Transporters for Anions (2015)

Abstract The synthesis and characterization of different pseudopeptidic hosts derived from open chain systems with C 2 and C 3 symmetry has been achieved. These receptors are based on structures containing phenylalanine amino acid residues and amine, amide, urea and thiourea groups as the structural elements providing their capability to interact with anions. The transport of chloride and organic anions of biological relevance ( L ‐lactate, L ‐maleate and L ‐aspartate) through lipid bilayer membranes has been studied for these receptors. The chloride‐binding properties of the selected hosts have been studied in solution by NMR titrations. In addition, in order to rationalize the results, lipophilicity studies have been carried out. It has been observed that transport activity is affected by the nature of the aliphatic central spacer and the side chains, the most active receptors being 9b , derived from a tripodal precursor with the shortest aliphatic side chain and 3c , derived from a bis(amino amide) but having the longest spacer. These hosts are more selective for the anion chloride than for the studied organic anions.
CHAPTER 16. Anti-Aging Action of PPARs: Potential Therapeutic Targets (2017)

Aging is accompanied by low-grade, chronic inflammatory states that contribute to metabolic syndrome, diabetes, and other age-related diseases. Emerging evidences strongly suggests that suppression of chronic inflammatory states can retard aging and age-related diseases. Among many molecular changes accompanying aging, decreased peroxisome proliferator activated receptor (PPAR) activity has been suggested as a major factor underlying age-related inflammation and metabolic diseases. The anti-inflammatory action of PPARs was established by in vitro and in vivo studies using several rodent models with PPAR agonists, verifying the importance of PPARs as major players in the pathogenesis of inflammatory diseases. In addition, recent works provided direct evidence of beneficial effects of PPAR agonists on aged rodents. Interestingly, activation of PPAR shows physiological changes similar to those observed under calorie restriction (CR), which is the most effective intervention known to delay aging and increase life span. Since drugs targeting PPARs have several adverse effects due to their off-target activity, the search for novel PPAR agonists with higher selectivity is currently under active investigation. This chapter highlights recent advances and current understanding of PPAR impacts on aging and describes the possibility of developing new therapeutic agents that modulate PPARs to control aging and age-related diseases.
Two-Step Process for the Synthesis of Dimethyldichlorosilane Using Copper Aluminate Catalysts (2020)

The present study relates to the development of a new generation of copper aluminate-type spinel catalysts for the production of dimethyldichlorosilane ((CH3)2SiCl2) from silicon tetrachloride (SiCl4) in a two-step reaction process. The first step is the reaction of SiCl4 with H2 over the spinel catalysts at high temperature (∼650 °C) to produce a copper–silicon-rich solid (copper silicide) by silicon deposition. In the second step, the silicon component of this solid reacts with CH3Cl at 300 °C to form (CH3)2SiCl2. Copper aluminates (CuAl2O4) were found to exhibit superior activity over other conventional copper catalysts and held better particle integrity in laboratory-scale fixed bed and fluid bed reactors. Their activity was maintained even at a 240 °C reaction temperature with CH3Cl, producing high selectivity toward (CH3)2SiCl2. Maximum production of (CH3)2SiCl2 was achieved right from the beginning of the reaction with CH3Cl without requiring any “activation period”. In contrast, the conventional Cu-supported catalysts required “an activation period” of several initial cycles to obtain maximum steady state activity. The high rate of methylchlorosilanes production on spinel catalysts is attributed to the smaller particle sizes of copper and the in situ formation of a reactive copper silicide (Cu3.17Si) phase as a result of the reaction with SiCl4/H2. The copper aluminate catalyst was tested in 45 experiments in time on stream and showed stable selectivity toward (CH3)2SiCl2 in a laboratory-scale fixed bed reactor. It demonstrated superior and acceptable attrition resistance and copper retention, whereas conventional supported copper catalysts did not retain the copper during piloting in a fluidized process. Overall, we developed a low cost, efficient, and scalable process to produce dimethyldichlorosilane ((CH3)2SiCl2).