gebhart/patrepeval huggingface dataset:
SIP Extensions for SPIT identification (2007)

This memo analyzes the need for SIP extensions for SPIT (Spam Over
Internet telephony) identification. This memo describes requirements
and gives an overview of possible solutions to send feedback
information using the SIP protocol for the scope of SPIT. Feedback
information from the users to the SPIT identification system (e.g.,
working closely with the callee's SIP proxy server) are important
for SPIT detection and prevention. The overall SPIT protection systems
on the internet will benefit from such information. The basic idea is
that each user who receives a SPIT session request, will send a
feedback to SPIT identification system (for example, using a button on
the user interface of the client). Information could be also exchanged
among domains and/or servers in order to increase effectiveness of
SPIT detection systems. The idea is that SIP proxy servers and/or
B2BUAs include SPIT likeliness estimations (based on some knowledge
they have which is out of the scope of this draft) as additional
message headers (e.g. INVITE headers) when forwarding such messages to
other domains. This memo identifies the parameters that the SPIT
identification system may need in order to detect abusive behaviors;
moreover it proposes an overview of technical solutions how such
information can be sent back to the SPIT identification system by
means of the SIP protocol. The memo also addresses the technical
solutions on how forward information could be passed among domains as
well as how communication initiation could be denied to users (e.g.
blacklisted ones).
Computer assisted three-dimensional plaque characterization in intracoronary ultrasound studies (2003)

The volume, morphology and composition of atherosclerotic plaque play an important role in coronary artery disease and in long-term outcome of coronary interventions and pharmaceutical strategies. Intracoronary ultrasound (ICUS) provides real-time cross-sectional imaging of vessel wall structures. In-vitro and in-vivo studies have shown that ICUS can identify the general composition of the plaque by assigning different grey levels to different tissue types. Ultrasound scanners use 256 grey levels, whereas the human eye can only discriminate 32. Therefore, computer-assisted grey level interpretation (labelling) and measurement can help identify different tissue types present in the plaque and track changes over time. This paper covers a new research tool that facilitates this and that provides an objective quantitative analysis parameter for the segmentation of plaque into four different tissue types.
Preclinical studies of non-stick thin film metallic glass-coated syringe needles (2020)

Our objective in this study was to determine the biocompatibility and hemocompatibility of thin film metallic glass (TFMG) and its potential use in hypodermic needles for intramuscular or intravenous injection. Mouse and rabbit models were employed under approval from the Institutional Animal Care and Use Committee (n = 5/group, two groups in total for both animal models). Platelet-rich plasma (PRP) was collected from the whole blood of rabbits (ear vein) without anti-coagulant for use in in vitro coagulation tests. Histological analysis and optical microscopy were used to assess the endothelial structure of the inner lining of veins after being punctured with needles and detained for 3 days. Histological analysis of ear vein sections revealed that the extent of endothelial damage after puncturing with a TFMG-coated needle was 33% less than that produced by bare needles. Our results confirm that the deposition of a thin TFMG layer (e.g., Zr<sub>53</sub>Cu<sub>33</sub>Al<sub>9</sub>Ta<sub>5</sub>) on the surface of hypodermic needle can have remarkably clinical benefits, including anti-adhesion, reduced invasion, and minimal endothelial damage. Our results also confirm the good biocompatibility and hemocompatibility of the TFMG coatings.
ChemInform Abstract: SYNTHESIS OF UNSYMMETRICAL OLEFINS BY TITANIUM(0) INDUCED MIXED CARBONYL COUPLING. SOME COMMENTS ON THE MECHANISM OF THE PINACOL REACTION (1977)

Abstract In Gegenwart von Titan führt die Reduktion der Ketone (I) in Gegenwart von überschüssigem Aceton (II) im wesentlichen zu den unsymmetrischen Olefinen (IV) neben den entsprechenden symmetrischen Olefinen aus (I) bzw. (II) allein.
CD11a Is Essential for Normal Development of Hematopoietic Intermediates (2014)

The process of lymphopoiesis begins in the bone marrow (BM) and requires multiple cellular intermediates. For T cell production, lymphoid progenitors exit the BM and home to the thymus where maturation and selection ensue. These processes are dependent on a number of factors, including chemokines and adhesion molecules. Although the β2 integrin CD11a plays an important role in the migration of lymphocytes to lymph nodes, the role of CD11a in T cell development is largely undefined. Our studies now show that, in CD11a(-/-) mice, thymic cellularity was decreased and early T cell development was partially impaired. Remarkably, CD11a was critical for generation of common lymphoid progenitors (CLPs) and lymphoid-primed multipotent progenitors. However, in intact CD11a(-/-) mice, peripheral B and T cell subsets were only modestly altered, suggesting that compensatory mechanisms were operating. In contrast, competitive BM-reconstitution assays revealed an essential role for CD11a in the generation of thymocytes and mature T and B cells. This defect was linked to the requirement for CD11a in the development of CLPs. Furthermore, our results identified CLPs, and not lymphoid-primed multipotent progenitors, as the requisite CD11a-dependent precursor for lymphocyte development. Thus, these findings established a key role for CD11a in lymphopoiesis.
Spectroscopic Evidence for a H Bond Network at Y<sub>356</sub> Located at the Subunit Interface of Active <i>E. coli</i> Ribonucleotide Reductase (2017)

The reaction catalyzed by E. coli ribonucleotide reductase (RNR) composed of α and β subunits that form an active α2β2 complex is a paradigm for proton-coupled electron transfer (PCET) processes in biological transformations. β2 contains the diferric tyrosyl radical (Y<sub>122</sub>·) cofactor that initiates radical transfer (RT) over 35 Å via a specific pathway of amino acids (Y<sub>122</sub>· ⇆ [W<sub>48</sub>] ⇆ Y<sub>356</sub> in β2 to Y<sub>731</sub> ⇆ Y<sub>730</sub> ⇆ C<sub>439</sub> in α2). Experimental evidence exists for colinear and orthogonal PCET in α2 and β2, respectively. No mechanistic model yet exists for the PCET across the subunit (α/β) interface. Here, we report unique EPR spectroscopic features of Y<sub>356</sub>·-β, the pathway intermediate generated by the reaction of 2,3,5-F<sub>3</sub>Y<sub>122</sub>·-β2/CDP/ATP with wt-α2, Y<sub>731</sub>F-α2, or Y<sub>730</sub>F-α2. High field EPR (94 and 263 GHz) reveals a dramatically perturbed g tensor. [<sup>1</sup>H] and [<sup>2</sup>H]-ENDOR reveal two exchangeable H bonds to Y<sub>356</sub>·: a moderate one almost in-plane with the π-system and a weak one. DFT calculation on small models of Y· indicates that two in-plane, moderate H bonds (r<sub>O-H</sub> ∼1.8-1.9 Å) are required to reproduce the g<sub>x</sub> value of Y<sub>356</sub>· (wt-α2). The results are consistent with a model, in which a cluster of two, almost symmetrically oriented, water molecules provide the two moderate H bonds to Y<sub>356</sub>· that likely form a hydrogen bond network of water molecules involved in either the reversible PCET across the subunit interface or in H<sup>+</sup> release to the solvent during Y<sub>356</sub> oxidation.
An Efficient On-chip Single-photon SWAP Gate for Entanglement Manipulation (2020)

We demonstrate an on-chip single photon SWAP gate between polarization and spatial-momentum qubit. Our SWAP gate shows gate fidelity of 97.44%, and polarization entanglement preservation of SWAP operation is confirmed with average visibility over 98%.
ChemInform Abstract: Novel Solution Phase Strategy for the Synthesis of Chemical Libraries Containing Small Organic Molecules. (1996)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Programmable spectral phase control of femtosecond pulses by use of adaptive optics and real-time pulse measurement (2004)

We describe a programmable spectral-phase, pulse-shaping system for femtosecond pulses based on a deformable membrane mirror. Accurate spectral phase design as well as pulse intensity modulation was achieved with direct control of the mirror surface by use of a negative-feedback, mirror-surface control mode. Convergence to the chosen spectral-phase design was typically achieved within several seconds. The pulses were measured with a real-time, second-harmonic-generation, frequency-resolved optical gating system.
The opposing homeobox genes Goosecoid and Vent1/2 self-regulate Xenopus patterning This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits distribution, and reproduction in any medium, provided the original author and source are credited. This license does not permit commercial exploitation or the creation of derivative works without specific permission. (2007)

Thisis an open-access article distributed under the terms ofthe Creative CommonsAttribution License, which permitsdistribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited.Thislicensedoesnotpermitcommercialexploitationorthecreationofderivativeworkswithoutspeciﬁcpermission.
fMRI of the auditory cortex in patients with unilateral carotid artery steno‐occlusive disease (2002)

This study shows that fMRI of the auditory cortex appears to have clinical merit in the workup of cerebrovascular conditions.
Gasless Lumbar Anterior Interbody Fusion Utilizing the B.E.R.G. Approach (1999)

Thalgott, John S.; Chin, Albert K.; Ameriks, John A.; Jordan, Frank T.; Daubs, Michael D.; Giuffre, James M.; Fritts, Kay
Wrench-Feasible Workspace of Mobile Cable-Driven Parallel Robots (2019)

Abstract Cable-driven parallel robots (CDPRs) hold numerous advantages over conventional parallel robots in terms of high speed and large workspace. Cable-driven parallel robots whose workspace can be further increased by the modification of their geometric architecture are known as reconfigurable cable-driven parallel robots. A novel concept of reconfigurable cable-driven parallel robots that consists of a classical cable-driven parallel robot mounted on multiple mobile bases is known as mobile CDPR. This paper proposes a methodology to trace the wrench-feasible workspace of mobile cable-driven parallel robots by determining its available wrench set. Contrary to classical cable-driven parallel robots, we show that the available wrench set of a mobile cable-driven parallel robot depends, not only on the cable tension limits but also on the static equilibrium conditions of the mobile bases. The available wrench set is constructed by two different approaches known as convex hull approach and hyperplane shifting method. Three case studies are carried out for the validation of the proposed methodology. The proposed approach is experimentally validated on a mobile cable-driven parallel robot with a point-mass end-effector and two mobile bases.
Preclinical and clinical evaluation of a novel synthetic bioresorbable, on-demand, light-activated sealant in vascular reconstruction (2019)

The new synthetic on-demand light activated PGSA-based SETALIUM™ Vascular Sealant investigated in our studies demonstrated good biocompatibility, sustained and gradual surface based bioresorption, and acceptable safety profile in animal studies. In addition, the first in-human use showed that the sealant is a safe and effective alternative to achieve fast and controlled hemostasis in vascular carotid reconstructions. A larger randomized controlled study will allow further validation of these encouraging preliminary results.
Juvenile Hormone-Receptor Complex Acts on Mcm4 and Mcm7 to Promote Polyploidy and Vitellogenesis in the Migratory Locust (2014)

Juvenile hormone (JH), a sesquiterpenoid produced by the corpora allata, coordinates insect growth, metamorphosis, and reproduction. While JH action for the repression of larval metamorphosis has been well studied, the molecular basis of JH in promoting adult reproduction has not been fully elucidated. Methoprene-tolerant (Met), the JH receptor, has been recently shown to mediate JH action during metamorphosis as well as in vitellogenesis, but again, the precise mechanism underlying the latter has been lacking. We have now demonstrated using Met RNAi to phenocopy a JH-deprived condition in migratory locusts, that JH stimulates DNA replication and increases ploidy in preparation for vitellogenesis. Mcm4 and Mcm7, two genes in the DNA replication pathway were expressed in the presence of JH and Met. Depletion of Mcm4 or Mcm7 inhibited de novo DNA synthesis and polyploidization, and resulted in the substantial reduction of vitellogenin mRNA levels as well as severely impaired oocyte maturation and ovarian growth. By using luciferase reporter and electrophoretic mobility shift assays, we have shown that Met directly regulates the transcription of Mcm4 and Mcm7 by binding to upstream consensus sequences with E-box or E-box-like motifs. Our work suggests that the JH-receptor complex acts on Mcm4 and Mcm7 to regulate DNA replication and polyploidy for vitellogenesis and oocyte maturation.
Chiral antenna element as a low backscattering sensor (2011)

For an antenna to operate as a sensor without disturbing the device under test, it should not backscatter any power toward the sensing direction. Here we propose a sensor antenna with such properties, that is very simple to manufacture. The antenna element is basically composed of two loaded wires that have been wound from the center to form two canonical chiral particles. One chiral particle is a combination of a loop and two wires, effectively a magnetic and an electric dipole, respectively. It is the appropriate combination of the dipoles, two electric and two magnetic altogether, that makes the operation possible. In this paper we study the scattering properties of the chiral antenna element. It is observed that whereas the antenna is able to receive power from the main beam direction, the scattered field is directed in the opposite direction with a Huygens' pattern and very little backscattering, that makes it suitable for sensor applications. Scattering from the antenna has in-plane isotropy respective to the plane of the elements, and works similarly for both TM and TE incident waves.
Numerical and experimental identification of fatigue crack initiation sites in clinched joints (2022)

Abstract In this paper, a study based on experimental and numerical simulations is performed to analyze fatigue cracks in clinched joints. An experimental investigation is conducted to determine the failure modes of clinched joints under cyclic loading at different load amplitudes with single-lap shear tests. In addition, numerical FEM simulations of clinching process and subsequent shear loading are performed to support the experimental investigations by analyzing the state of stresses at the location of failure. An attempt is made to explain the location of crack initiation in the experiments using evaluation variables such as contact shear stress and maximum principal stress.
The Intra-articular Effect of Various Postoperative Managements Following Knee Ligament Repair (1980)

The intra-articular changes in dog knees were studied following repair of the anterior cruciate and medial collateral ligaments under various postoperative managements: early mobilization, immobilization for 6 weeks in a plaster cast, and limited mobilization for 4 weeks in a cast-brace. The animals were sacrificed at 12 weeks after operation and osteoarthritic changes were graded according to the system described by Mankin et al. The osteoarthritic changes of the knee joints in the mobilized group were significantly less than those in the immobilized and in the cast-brace groups. Medial collateral ligaments were found well healed in most animals; however, anterior cruciate ligaments showed poor healing in the animals treated with early unlimited motion. Postoperative immobilization for more than 6 weeks causes considerable damage to the articular cartilage while early unlimited motion appears to compromise healing of the anterior cruciate ligaments.
Free Charge Photogeneration in a Single Component High Photovoltaic Efficiency Organic Semiconductor (2021)

Abstract Organic photovoltaic cells promise cheap, flexible and scalable solar energy. Whereas light directly generates free charges in silicon photovoltaic cells, bound electron and hole pairs known as excitons are understood to be the primary excitations in organic semiconductors due to their low dielectric constants. These excitons must then be split apart at molecular heterojunctions in order to extract current. Recent record efficiency organic photovoltaics utilise the small molecule, Y6, as a key component in the photon-absorbing blend layer. This molecule and its analogues – unlike previous organic semiconductors – have both low band-gaps and high dielectric constants. Here we show that, in a neat film of Y6, these factors lead to intrinsic free charge generation without the need for a molecular heterojunction to split the exciton. We use a suite of intensity-dependent optical spectroscopy measurements to show that a significant (20-90%) fraction of free charges exist in equilibrium with bound states at light intensity equivalent to 1 sun. Rapid bimolecular charge recombination constrains single component Y6 organic photovoltaic devices to low efficiencies, but this recombination is reduced by the introduction of small quantities of donor polymer. Quantum-chemical calculations reveal charge generation pathways through strong coupling between exciton and CT states, and an intermolecular polarisation pattern that drives exciton dissociation. Our results challenge the understanding of how current record efficiency organic photovoltaics operate, and point towards new future possibilities – offering a molecular picture of intrinsic charge generation as a platform to improve charge yields, and renewing the possibility of efficient single-component organic photovoltaic devices.
Diagnostic Accuracy in Coronary Stenosis (2010)

The accuracy of QCTA is comparable with that of QCA and visual score especially in noncalcified vessels. Editing of the vessel contours in case of calcified vessels is helpful in correctly estimating the right percentage of stenosis.
Efficient gene silencing in metastatic tumor by siRNA formulated in surface-modified nanoparticles (2020)

We have developed a nanoparticle (NP) formulation for systemically delivering siRNA into metastatic tumors. The NP, composed of nucleic acids, a polycationic peptide and cationic liposome, was prepared in a self-assembling process. The NP was then modified by PEG-lipid containing a targeting ligand, anisamide, and thus was decorated for targeting sigma receptor expressing B16F10 tumor. The activity of the targeted NP was compared with the naked NP (no PEGylation) and non-targeted NP (no ligand). The delivery efficiency of the targeted NP was 4-fold higher than the non-targeted NP and could be competed by excess free ligand. Luciferase siRNA was used to evaluate the gene silencing activity in the B16F10 cells, which were stably transduced with a luciferase gene, in a lung metastasis model. The gene silencing activity of the targeted NP was significantly higher than the other formulations and lasted for 4 days. While confocal microscopy showed the naked NP provided no tissue selectivity and non-targeted NP was ineffective for tumor uptake, the targeted NP effectively penetrated the lung metastasis, but not the liver. It resulted in 70-80% gene silencing in the metastasis model after a single i.v. injection (150 μg siRNA/kg). This effective formulation also showed very little immunotoxicity.
Low Cost Robotized Gearshift System for Formula SAE Vehicles (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;This paper reports the studies, design and developments of an electronic electro-actuated gearshifter installed on the DP7, which is Politecnico di Milano car that took part at Formula SAE 2015 competitions in Hockenheim and Varano dè Melegari.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;The original idea was born to replace the hydraulic gearshift system used until 2011 because of its high weight and cost. After many evaluations about the kind of technology to use, made by previous team members in the electronic department, the final project was a fully electric shifter. This system has proven its qualities among which are lightness and low cost.&lt;/div&gt;&lt;/div&gt;
Une horlogerie mécanique sans tic-tac (2017)

INSTANT-LAB
RAMP 202: A phase 2 study of avutometinib (VS-6766) ± defactinib, in patients with advanced <i>KRAS</i> G12V mutant non–small cell lung cancer (NSCLC). (2023)

9100 Background: KRAS mutations (mt) occur in ~30% of lung adenocarcinomas, among which G12C is most common (40%), followed by G12V (22%) and G12D (16%). Approved treatments for advanced KRAS mt NSCLC (excluding G12C) are limited to chemotherapy and immune checkpoint inhibitors (ICIs). Avutometinib is a novel small molecule RAF/MEK clamp. Focal adhesion kinase (FAK) activation is a resistance mechanism to RAF/MEK inhibition. Defactinib, a small molecule FAK inhibitor, has shown synergistic antitumor activity with avutometinib in preclinical models. In prior studies, avutometinib ± defactinib has shown responses in patients (pts) with KRAS mt NSCLC, including KRAS G12V. Methods: RAMP 202 is a randomized, phase 2, adaptive, multicenter, open-label study evaluating the efficacy and safety of avutometinib ± defactinib in previously-treated KRAS mt NSCLC (NCT04620330). Key inclusion criteria include histologically confirmed NSCLC with known KRAS mt and ≥1 prior systemic therapy (platinum-based and immune checkpoint inhibitor or appropriate therapy for activating mutation). Part A evaluated the optimal regimen, either 4.0 mg avutometinib orally (PO), twice weekly, 3 weeks on, 1 week off (mono) or 3.2 mg avutometinib PO twice weekly + 200 mg defactinib PO twice per day, 3 weeks on, 1 week off (combo) in pts with KRAS G12V mt NSCLC. Primary endpoint was confirmed objective response rate (ORR) by blinded independent central review. The optimal regimen determined in Part A would subsequently be assessed for efficacy in Part B. Exploratory assessment of ORR is also planned in KRAS-other (non-G12V) NSCLC. Results: Of 35 pts with KRAS G12V enrolled to Part A, 16 pts received mono, and 19 received combo. Patients received up to 5 lines of prior systemic therapy (median 2), including prior platinum-based chemotherapy, ICIs, and bevacizumab. No confirmed responses were seen in the mono group. In the combo group, 2 pts (11%) experienced a confirmed partial response. The duration of each response was 7.9 and 8.5 months, with both ongoing at data cut. The majority of treatment-related adverse events (TRAEs, any grade) (N = 72) were mild to moderate. The most common Grade ≥3 TRAEs included blood CPK increase (11.1%), diarrhea (5.6%), anemia (5.6%), and rash (1.4%). Most AEs were manageable/reversible. Conclusions: In this heavily pretreated population of patients with KRAS G12V mt NSCLC, limited clinical activity was observed with combination therapy. While no new safety signals were identified, criteria to proceed to part B were not met, and further evaluation of avutometinib ± defactinib in KRAS G12V mt NSCLC will not be pursued. Additional trials evaluating rational avutometinib combinations (sotorasib, adagrasib, everolimus) are ongoing in patients with KRAS mt NSCLC. Clinical trial information: NCT04620330 .