gebhart/patrepeval huggingface dataset:
Does Low Clearance Resurfacing Arthroplasty Increase in Vivo Bearing Friction? a 6-Year Prospective Study. (2018)

IntroductionHip simulator studies show that metal-on-metal bearing wear can be reduced by reducing the diametral clearance of the bearing. We present the six-year follow-up results of a prospective...
Influence of vibrational excitation and collision energy on the ion-molecule reaction NH+3(ν2)+ND3 (1994)

The influence of vibrational excitation and collision energy on the ion-molecule reaction NH+3(ν2)+ND3 has been investigated using a recently constructed quadrupole-octopole-quadrupole mass spectrometer. The NH+3 reagent ions are prepared state selectively with 0–7 quanta in the ν2 umbrella bending mode by (2+1) resonance enhanced multiphoton ionization through the B̃ or C̃′ Rydberg states of ammonia. Reactive collisions between the mass-filtered ion beam and a thermal distribution of neutral reagent molecules occur with controlled collision energies (0.5–10.0 eV center of mass) within the octopole ion guide, enabling product ions to be collected independent of scattering dynamics. The reaction of NH+3 with ND3 has three major product channels: (1) deuterium abstraction, (2) charge transfer, and (3) proton transfer. Each of these channels exhibits a strong dependence on ion vibrational excitation and collision energy. Product branching ratios and relative cross sections are reported and compared with previous results. Briefly, both deuterium abstraction and charge transfer are enhanced by vibrational excitation, whereas proton transfer is suppressed. As the collision energy increases, the branching fraction for charge transfer increases sharply, that for proton transfer decreases, and that for deuterium abstraction remains nearly unchanged. These results point to a short-lived collision complex in which vibration and translation play inequivalent roles.
Energetic electrochemiluminescence of (9-fluorenyl)methanol induced by injection of hot electrons into aqueous electrolyte solution (1997)

Hot electron injection into aqueous electrolyte solutions from metal/insulator/metal/electrolyte and metal/insulator/electrolyte tunnel junctions is considered and the possibility of an electrochemical generation of hydrated electrons is discussed. The hot electron-induced UV electrochemiluminescence of (9-fluorenyl)methanol was used to demonstrate the presence of highly energetic transient species in aqueous solution at several metal/insulator/electrolyte hot electron tunnel emitters. These transient species cannot be produced electrochemically in fully aqueous solutions at any active metal electrodes. A detailed mechanism for the present electrochemiluminescence is suggested.
High-Quality Assemblies for Three Invasive Social Wasps from the Vespula Genus (2021)

&lt;div&gt;&lt;div&gt;&lt;div&gt;&lt;p&gt;Social wasps of the genus Vespula have spread to nearly all landmasses worldwide and have become significant pests in their introduced ranges, affecting economies and biodiversity. Comprehensive genome assemblies and annotations for these species are required to develop the next generation of control strategies and monitor existing chemical control. We sequenced and annotated the genomes of the common wasp (Vespula vulgaris), German wasp (Vespula germanica), and the western yellowjacket (Vespula pensyl- vanica). Our chromosome-level Vespula assemblies each contain 176–179 Mb of total sequence assembled into 25 scaffolds, with 10–200 unanchored scaffolds, and 16,566–18,948 genes. We annotated gene sets relevant to the applied management of invasive wasp populations, including genes associated with spermatogenesis and development, pesticide resistance, olfactory receptors, immunity and venom. These genomes provide evidence for active DNA methylation in Vespidae and tandem duplications of venom genes. Our genomic resources will contribute to the development of next-generation control strategies, and monitoring potential resistance to chemical control.&lt;/p&gt;&lt;/div&gt;&lt;/div&gt;&lt;/div&gt;
A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture (2023)

Abstract The pathogenesis of severe Plasmodium falciparum malaria involves cytoadhesive microvascular sequestration of infected erythrocytes, mediated by P. falciparum erythrocyte membrane protein 1 (PfEMP1). PfEMP1 variants are encoded by the highly polymorphic family of var genes, the sequences of which are largely unknown in clinical samples. Previously, we published new approaches for var gene profiling and classification of predicted binding phenotypes in clinical P. falciparum isolates (Wichers et al., 2021), which represented a major technical advance. Building on this, we report here a novel method for var gene assembly and multidimensional quantification from RNA-sequencing that even outperforms the earlier approach of Wichers et al., 2021 on both laboratory and clinical isolates across a combination of metrics. It is a powerful tool to interrogate the var transcriptome in context with the rest of the transcriptome and can be applied to enhance our understanding of the role of var genes in malaria pathogenesis. We applied this new method to investigate changes in var gene expression through early transition to in vitro culture, using paired sets of ex vivo samples from our previous study, cultured for up to three generations. In parallel, changes in non-polymorphic core gene expression were investigated. Unpredictable var gene switching and convergence towards var2csa were observed in culture, along with differential expression of 19% of the core transcriptome between paired ex vivo and generation 1 samples. Our results cast doubt on the validity of the common practice of using short-term cultured parasites to make inferences about in vivo phenotype and behaviour.
Transcriptomic Analysis of Leaf Sheath Maturation in Maize (2019)

The morphological development of the leaf greatly influences plant architecture and crop yields. The maize leaf is composed of a leaf blade, ligule and sheath. Although extensive transcriptional profiling of the tissues along the longitudinal axis of the developing maize leaf blade has been conducted, little is known about the transcriptional dynamics in sheath tissues, which play important roles in supporting the leaf blade. Using a comprehensive transcriptome dataset, we demonstrated that the leaf sheath transcriptome dynamically changes during maturation, with the construction of basic cellular structures at the earliest stages of sheath maturation with a transition to cell wall biosynthesis and modifications. The transcriptome again changes with photosynthesis and lignin biosynthesis at the last stage of sheath tissue maturation. The different tissues of the maize leaf are highly specialized in their biological functions and we identified 15 genes expressed at significantly higher levels in the leaf sheath compared with their expression in the leaf blade, including the <i>BOP2</i> homologs <i>GRMZM2G026556</i> and <i>GRMZM2G022606</i>, <i>DOGT1</i> (<i>GRMZM2G403740</i>) and transcription factors from the B3 domain, C2H2 zinc finger and homeobox gene families, implicating these genes in sheath maturation and organ specialization.
Geometric defects induced by strain relaxation in thin film oxide superlattices (2022)

Functional thin film superlattices with stability in extreme environments can lead to transformative performance in optical and thermal applications such as thermophotovoltaics. In this work, key issues associated with defects that prevent layer-by-layer growth in epitaxial, low-miscibility oxide superlattices are investigated. Layer protrusions, approximately 8 nm wide and 3 nm thick, arise from a strain relaxation mechanism in 8 nm bilayer superlattices of Ba(Zr0.5Hf0.5)O3/MgO and propagate through the subsequent superlattice layers forming an inverted pyramid structure that is spatially phase offset from the matrix. The density and size of these defects scales with the number of interfaces in the sample, indicating that surface roughness during growth is a significant factor in the formation of these defects. In situ high temperature transmission electron microscopy (1000 °C, in vacuo) measurement reveals that phase decomposition of Ba(Zr0.5Hf0.5)O3 and decoherence of the superlattice is nucleated by these defects. This work highlights that achieving optimum growth conditions is imperative to the synthesis of single-crystalline superlattices with sharp interfaces for optimized performance in extreme environments.
Findings on the Electron‐Attachment‐Induced Abasic Site in a DNA Double Helix (2007)

Große Wirkung: Aus der Potentialenergiefläche für die Bildung einer abasischen Stelle (Pabasisch) lässt sich schließen, dass niederenergetische Elektronen (LEEs) möglicherweise die Bildung einer solchen Stelle am 3′-Ende einer DNA-Doppelhelix mit einem Cytidinrest als Strangende induzieren. Die Aufnahme dieser LEEs durch die DNA-Helix könnte zu strahlungsinduzierten DNA-Schäden beitragen. TS=Übergangszustand.
PO-185 Towards dynamic targeting of TGF-β in metastatic melanoma using intravital microscopy (2018)

Introduction Melanoma patients diagnosed with liver metastasis have a poor prognosis. TGF-β inhibitors give mixed results in clinical trials with metastatic melanoma patients. To more specifically target TGF-β in liver metastasis melanoma patients, it is necessary to unravel the spatio-temporal function of the TGF-β pathway in hepatic colonisation of melanoma cells. TGF-β is a multifunctional cytokine that signals via TGF-β receptors and downstream SMAD effector proteins. SMAD proteins regulate transcription by binding, among others, to CAGA elements in the DNA. It can exert both pro-and anti-tumorigenic functions, depending on cellular context. It acts on tumour cells, as well as the tumour micro-environment and the immune system. In metastatic melanoma cells, TGF-β can stimulate invasion and metastasis. To unravel its exact role during the different processes of metastasis, we will investigate the spatio-temporal patterns of TGF-β signalling during metastatic colonisation using intravital microscopy (IVM). Material and methods Spatio-temporal patterns of TGF-β signalling will be studied in vitro and in vivo . For our in vivo studies, we are using an experimentally induced liver metastasis model, injecting highly aggressive B16F10 melanoma cells in immune competent C57BL/6 mice. By injecting these tumour cells in the mesenteric vein, cells will be transported directly to the liver, the first capillary network the cells will encounter. An abdominal imaging window will be placed after cell injection to visualise the different steps of metastasis in real-time using IVM. We developed a rapid CAGA 12 -GFP-based transcriptional reporter, which expresses a fluorophore upon TGF-β receptor activation and SMAD binding. Upon the expression of this reporter in B16F10 cells, activation of the TGF-β pathway can be monitored over time. By genetic manipulation of B16F10 cells to express dominant negative or constitutively active TGF-β receptors, the role of TGF-β can be assessed for the different steps of metastasis. Results and discussions We confirmed earlier reports showing that B16F10 cells show a transcriptional CAGA response upon TGF-β3 stimulation. Using our liver metastasis model, the injected B16F10 cells are able to perform the steps of metastasis and form liver metastasis within a short time frame. The use of the rapid TGF-β reporter during intravital imaging will show the involvement of the TGF-β pathway in the different phases of metastasis. Conclusion B16F10 cells have a functional TGF-β pathway and are able to colonise the liver.
Crosstalk Between SMPDL3b and NADPH Oxidases Mediates Radiation-Induced Damage of Renal Podocytes (2021)

Patients undergoing radiotherapy (RT) for various tumors localized in the abdomen or pelvis often suffer from radiation nephrotoxicity as collateral damage. Renal podocytes are vulnerable targets for ionizing radiation and contribute to radiation-induced nephropathies. Our prior work previously highlighted the importance of the lipid-modifying enzyme sphingomyelinase acid phosphodiesterase like 3b (SMPDL3b) in modulating the radiation response in podocytes and glomerular endothelial cells. Hereby, we investigated the interplay between SMPDL3b and oxidative stress in mediating radiation injury in podocytes. We demonstrated that the overexpression of SMPDL3b in cultured podocytes (OE) reduced superoxide anion generation and NADPH oxidase activity compared to wild-type cells (WT) post-irradiation. Furthermore, OE podocytes showed downregulated levels of NOX1 and NOX4 after RT. On the other hand, treatment with the NOX inhibitor GKT improved WTs' survival post-RT and restored SMPDL3b to basal levels. <i>in vivo</i>, the administration of GKT restored glomerular morphology and decreased proteinuria in 26-weeks irradiated mice. Taken together, these results suggest a novel role for NOX-derived reactive oxygen species (ROS) upstream of SMPDL3b in modulating the response of renal podocytes to radiation.
CONCEPCIONES EN TORNO A LA MENSTRUACIÓN: UN ABORDAJE INTERDISCIPLINARIO (2004)

Esta presentacion se desprende de una investigacion exploratoria-descriptiva cuyo proposito es mejorar el acercamiento del equipo de salud hacia la poblacion femenina, a traves de la desconstruccion y/o confirmacion de preconceptos instalados en los profesionales de salud, indagando sobre las representaciones sociales de las mujeres en relacion a su propio cuerpo y la sexualidad. En este trabajo focalizaremos en uno de los ejes de investigacion: las concepciones sobre la menstruacion de las mujeres en edad fertil que concurrieron a los grupos de informacion, durante el periodo 2000-2003 en los CeSAC No 7 (Barrio Piedrabuena) y No 29 (Villa 19 - Barrio Inta), Area Programatica del Hospital Santojanni, Secretaria de Salud del GCBA, centrandonos en los registros observacionales que se tomaron durante el desarrollo de los grupos, como fuente de informacion. Hasta el momento, los resultados obtenidos demuestran que la menstruacion se asocia a significaciones sociales, culturales, psicologicas y fisicas, que requieren de un abordaje interdisciplinario desde un equipo de salud.
Resumen en Ingles
This presentation arises from an exploratory-descriptive investigation whose purpose is to improve the approach of the health team towards the female population, through the deconstruction and/or confirmation of preconceptions established in health professionals. This will be done by looking into the social representations of women towards their own bodies and sexuality. In this work, we will focus on one of the possible branches of research: the conceptions around menstruation of women in fertile age that attended the informational groups at the Health Centers (CeSAC ) number 7 (Piedrabuena Neighborhood) and number 29 (Villa 19  Inta Neighborhood) during the 2000-2003 period. Observational records taken during the informational group sessions will be used as source of information. Until now, the results show that menstruation is associated with social, cultural, psychological and physical significances that require an interdisciplinary approach of a health team.
Palabras Clave
Mujeres  Menstruacion- Representacion- Sexualidad
Correction: Piscine Reovirus: Genomic and Molecular Phylogenetic Analysis from Farmed and Wild Salmonids Collected on the Canada/US Pacific Coast (2016)

In "Piscine Reovirus: Genomic and Molecular Phylogenetic Analysis from Farmed and Wild Salmonids Collected on the Canada/US Pacific Coast, " by Siah et al. [1], clarifications were needed in regards to the following: (a) the sampling population used in this paper versus that of Kibenge et al. [2] and; (b) the discussion of work by Kibenge et al. [2]. Additionally, there was an error in Fig 6 and Table
Carbon, 4. Industrial Carbons (2010)

The article contains sections titled: 1. Polygranular Carbon and Graphite 1.1. Raw Materials 1.1.1. Petroleum Coke 1.1.2. Coal-Tar Pitch Coke 1.1.3 Anthracite 1.1.4. Binder Materials 1.2. Manufacturing 1.3. Properties 1.4. Applications 2. Other Classes of Carbon 2.1. Glass-like Carbon 2.2. Pyrocarbon and Pyrographite 3. Graphite Compounds 3.1. Surface Complexes 3.2. Graphite Intercalation Compounds 4. Natural Graphite 4.1. Mining and Cleaning 4.2. Applications 4.3. Economic Aspects 5. Expanded Graphite and Graphite Foils 5.1. Production 5.2. Properties 5.3 Applications 5.3.1. Sealing Applications 5.3.2. Conductive Fillers 5.3.3. Latent Heat Storage 5.3.4. Other Applications 5.4 Economic Aspects
Three-dimensional integration technology for sensor application using 5-µm-pitch au cone bump connections (2015)

This paper presents the experimental results of a pixel detector device fabricated with 3-μmφ gold cone bump connections using adhesive injections. The as-deposited cone bump consists of gold nanoparticles and is easier to deform than plating gold. Consequently, the collapsibility of the gold cone bump allows for low-stress bonding, resulting in a compliant and reliable junction. The size of the bump is determined by photoresist patterning, and its connections do not protrude significantly during junction formation, in contrast with melting-type bump connections. In addition, the shrink ratio of the volume is larger than that of the surface area. The bump resistance of an easily oxidized metal with a diameter of a few microns is affected by the bonding atmosphere. In contrast, bonding with a micro gold cone bump does not adversely affect the electrical characteristics because gold is an oxidation-resistant material. The resistance per bump is approximately 6 Ω with a robust junction formed. The influence of the stress caused by the bump junction on the MOS characteristics is also investigated.
Disentanglement for Audio-Visual Emotion Recognition Using Multitask Setup (2021)

Deep learning models trained on audio-visual data have been successfully used to achieve state-of-the-art performance for emotion recognition. In particular, models trained with multitask learning have shown additional performance improvements. However, such multitask models entangle information between the tasks, encoding the mutual dependencies present in label distributions in the real world data used for training. This work explores the disentanglement of multimodal signal representations for the primary task of emotion recognition and a secondary person identification task. In particular, we developed a multitask framework to extract low-dimensional embeddings that aim to capture emotion specific information, while containing minimal information related to person identity. We evaluate three different techniques for disentanglement and report results of up to 13% disentanglement while maintaining emotion recognition performance.
TriG - A GNSS Precise Orbit and Radio Occultation Space Receiver (2009)

The GPS radio occultation (RO) technique [1] produces&#13;\nmeasurements in the ionosphere and neutral atmosphere&#13;\n[2] that contribute to monitoring space weather and climate&#13;\nchange; and improving operational weather prediction.&#13;\nThe high accuracy of RO soundings, traceable to SI standards,&#13;\nmakes them ideal climate benchmark observations. For&#13;\nweather applications, RO observations improve the accuracy&#13;\nof weather forecasts by providing temperature and moisture&#13;\nprofiles of sub-km vertical resolution, over land and ocean&#13;\nand in the presence of clouds.&#13;\nJPL is currently flying a handful of RO instruments [3] on&#13;\nvarious satellites in Low Earth Orbit (LEO). Although these&#13;\nreceivers have served to pioneer occultation measurements,&#13;\nvarious advances in technology and understanding of the RO&#13;\ntechnique along with availability of new signals from GPS and&#13;\nother GNSS satellites allow us to design an improved next&#13;\ngeneration space-based Precise Orbit Determination (POD)&#13;\nand RO receiver, the TriG receiver. The paper describes the&#13;\narchitecture and implementation of the JPL TriG receiver as&#13;\nwell as results obtained with a prototype receiver demonstrating&#13;\nkey technologies necessary for a next-generation space&#13;\nscience receiver.
A MEMS Implementation of the Classic Meissner Parametric Resonator: Exploring High-Order Windows of Unbounded Response (2017)

In recent years, increasing attention is given to parametric resonators, in which an unbounded response may be induced by periodically modulating one of the system parameters. Parametric resonators with a single degree of freedom have many windows of unbounded response in which the response frequency is different from the modulation frequency. This difference between input and output frequencies may be relevant to sensing applications. In this paper, we explore the solution map of the Meissner parametric resonator, and we experimentally characterize odd-ordered windows of unbounded response, up to the 15th window. Another interesting feature of the Meissner resonator is discrete crossover points in which an unbounded response is possible at distinct modulation frequencies and distinct modulation amplitudes. In this paper, we experimentally characterize one such crossover point. Our parametric resonator is based on an electrostatic anti-spring, which allows to modulate stiffness that is otherwise unaffected by motion. This is in contrast to many previous experimental studies in which the modulated stiffness was affected by motion and thus included unwanted nonlinear effects.
Amyloid-ß and Treatment Opportunities for Alzheimer's Disease (2000)

Proposed treatments of Alzheimer's disease (AD) are most likely to succeed if they are based on an understanding of the complex biology of AD and its effects on cognition. Treatments may target a single or multiple components of the complex pathology of AD with the hope that by affecting an individual component of AD pathology, the disease course can be affected. One such component is amyloid-beta (Abeta), a feature of the senile plaque. Abeta may be critical for inducing the pathology seen in AD. Accumulation of Abeta may result in a cascade of biochemical events leading to neuronal dysfunction, which may present opportunities for intervention at multiple different points to slow disease progression. Treatment may be directed towards decreasing Abeta production, increasing Abeta removal, and decreasing Abeta aggregation. Alternatively, treatment may be directed at more distal pathways by: modulating downstream events possibly due to Abeta such as free radical toxicity, decreasing inflammation, preventing cell membrane damage, restoring calcium homeostasis, preventing excitotoxicity, and blocking the cellular response to injury by inhibiting neuronal apoptosis. This review underscores the complex biology of Abeta specifically looking at the potential targets of therapeutics based on emerging knowledge of this biology.
Effects of Genetic Transformation on Fitness of<i>Cochliobolus heterostrophus</i> (1990)

The fitness of genetically transformed strains of the southern corn leaf blight fungus Cochliobolus heterostrophus was compared to that of the isogenic wild-type progenitor in competitive pathogenicity tests on maize plants. Fitness (an individual's contribution to the gene pool of the next generation) was assessed by monitoring the frequency of the transformed phenotype in mixed populations with the wild type after successive disease cycles. Transformants were less fit than the wild type in 92% of the competition tests (P=0.05) (...)