gebhart/patrepeval huggingface dataset:
Aberrant airway epithelial differentiation resulting from cigarette smoke exposure leads to loss of constitutive antimicrobial peptide and protein (AMP) expression (2016)

Respiratory infections are a major health burden in smokers, and contribute to exacerbations, development and progression of chronic obstructive pulmonary disease (COPD). The mechanisms underlying the increased susceptibility of smokers with or without COPD to these infections can be attributed in part to disrupted mucociliary clearance by the airway epithelium. Currently it is incompletely understood how cigarette smoke (CS) affects production of constitutively expressed AMPs, an important contributor to epithelial antimicrobial barrier function. We hypothesized that CS-induced alterations in epithelial differentiation result in a decrease in constitutively expressed AMPs, thus rendering the host more susceptible to infection. To investigate this, primary bronchial epithelial cells (PBEC;n=7) were cultured at the air-liquid interface and daily exposed to CS for 2-3 weeks. Markers of basal and luminal epithelial cells and AMPs were assessed by qPCR, ELISA and immunofluorescence. Results showed that PBEC differentiation into luminal cells was significantly (p&lt;0.05) compromised by CS. Marked differences in AMPs expression by luminal and basal epithelial cells were detected, indicating their polarized expression in the airway epithelial layer. CS thereby significantly limited the presence of AMPs that are expressed by these luminal epithelial cells. In summary, these new findings highlight the importance of airway epithelial cell differentiation in host defence against microbes. Supported by a Marie Curie Intra-European Fellowship (#622815), Galapagos N.V and the Lung Foundation Netherlands (grant # 5.1.13.033).
Synthesis and structure of the lithium bromide-pentamethyldiethylenetriamine 1:1 adduct (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of the lithium bromide-pentamethyldiethylenetriamine 1:1 adductSydney R. Hall, Colin L. Raston, Brian W. Skelton, and Allan H. WhiteCite this: Inorg. Chem. 1983, 22, 26, 4070–4073Publication Date (Print):December 1, 1983Publication History Published online1 May 2002Published inissue 1 December 1983https://pubs.acs.org/doi/10.1021/ic00168a049https://doi.org/10.1021/ic00168a049research-articleACS PublicationsRequest reuse permissionsArticle Views165Altmetric-Citations26LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Supporting Communication and Coordination in Collaborative Sensemaking (2014)

When people work together to analyze a data set, they need to organize their findings, hypotheses, and evidence, share that information with their collaborators, and coordinate activities amongst team members. Sharing externalizations (recorded information such as notes) could increase awareness and assist with team communication and coordination. However, we currently know little about how to provide tool support for this sort of sharing. We explore how linked common work (LCW) can be employed within a `collaborative thinking space', to facilitate synchronous collaborative sensemaking activities in Visual Analytics (VA). Collaborative thinking spaces provide an environment for analysts to record, organize, share and connect externalizations. Our tool, CLIP, extends earlier thinking spaces by integrating LCW features that reveal relationships between collaborators' findings. We conducted a user study comparing CLIP to a baseline version without LCW. Results demonstrated that LCW significantly improved analytic outcomes at a collaborative intelligence task. Groups using CLIP were also able to more effectively coordinate their work, and held more discussion of their findings and hypotheses. LCW enabled them to maintain awareness of each other's activities and findings and link those findings to their own work, preventing disruptive oral awareness notifications.
P‐P and P‐S stereotomography : application to a 2D‐OBC‐4C real dataset (2003)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2003P‐P and P‐S stereotomography : application to a 2D‐OBC‐4C real datasetAuthors: Gilles LambaréJean‐Luc BoëlleMathias AleriniGilles LambaréÉcole des Mines de Paris (France), Jean‐Luc BoëlleTotalFinaElf (France), and Mathias Alerinihttps://doi.org/10.1190/1.1818060 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InReddit Permalink: https://doi.org/10.1190/1.1818060FiguresReferencesRelatedDetailsCited byStereotomography: a semi‐automatic approach for velocity macromodel estimation2 November 2004 | Geophysical Prospecting, Vol. 52, No. 6Stereotomographic picking in practiceGilles Lambaré, Mathias Alerini, and Pascal Podvin3 January 2005 SEG Technical Program Expanded Abstracts 2003ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2003 Pages: 2452 publication data© 2003 Copyright © 2003 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 03 Jan 2005 CITATION INFORMATION Gilles Lambaré, Jean‐Luc Boëlle, and Mathias Alerini, (2003), "P‐P and P‐S stereotomography : application to a 2D‐OBC‐4C real dataset," SEG Technical Program Expanded Abstracts : 809-812. https://doi.org/10.1190/1.1818060 Plain-Language Summary PDF DownloadLoading ...
Georeferencing of photovoltaic modules from aerial infrared videos using structure‐from‐motion (2022)

Abstract To identify abnormal photovoltaic (PV) modules in large‐scale PV plants economically, drone‐mounted infrared (IR) cameras and automated video processing algorithms are frequently used. While most related works focus on the detection of abnormal modules, little has been done to automatically localize those modules within the plant. In this work, we use incremental structure‐from‐motion to automatically obtain geocoordinates of all PV modules in a plant based on visual cues and the measured GPS trajectory of the drone. In addition, we extract multiple IR images of each PV module. Using our method, we successfully map 99.3% of the 35,084 modules in four large‐scale and one rooftop plant and extract over 2.2 million module images. As compared to our previous work, extraction misses 18 times less modules (one in 140 modules as compared to one in eight). Furthermore, two or three plant rows can be processed simultaneously, increasing module throughput and reducing flight duration by a factor of 2.1 and 3.7, respectively. Comparison with an accurate orthophoto of one of the large‐scale plants yields a root mean square error of the estimated module geocoordinates of 5.87 m and a relative error within each plant row of 0.22 m to 0.82 m. Finally, we use the module geocoordinates and extracted IR images to visualize distributions of module temperatures and anomaly predictions of a deep learning classifier on a map. While the temperature distribution helps to identify disconnected strings, we also find that its detection accuracy for module anomalies reaches, or even exceeds, that of a deep learning classifier for seven out of ten common anomaly types. The software is published at https://github.com/LukasBommes/PV-Hawk .
RxRx1: A Dataset for Evaluating Experimental Batch Correction Methods (2023)

High-throughput screening techniques are commonly used to obtain large quantities of data in many fields of biology. It is well known that artifacts arising from variability in the technical execution of different experimental batches within such screens confound these observations and can lead to invalid biological conclusions. It is therefore necessary to account for these batch effects when analyzing outcomes. In this paper we describe RxRx1, a biological dataset designed specifically for the systematic study of batch effect correction methods. The dataset consists of 125,510 high-resolution fluorescence microscopy images of human cells under 1,138 genetic perturbations in 51 experimental batches across 4 cell types. Visual inspection of the images alone clearly demonstrates significant batch effects. We propose a classification task designed to evaluate the effectiveness of experimental batch correction methods on these images and examine the performance of a number of correction methods on this task. Our goal in releasing RxRx1 is to encourage the development of effective experimental batch correction methods that generalize well to unseen experimental batches. The dataset can be downloaded at https://rxrx.ai.
Stimulated Raman scattering imaging with quantum-enhanced balanced detection (2022)

We demonstrate the experimental realization of a high-power quantum-enhanced stimulated Raman scattering (QE-SRS) microscopy. By using a 25-mW squeezed light, we achieved 1.74±0.28 dB quantum enhancement in high-speed hyperspectral SRS imaging.
Phase 2 study of belzutifan (MK-6482), an oral hypoxia-inducible factor 2α (HIF-2α) inhibitor, for Von Hippel-Lindau (VHL) disease-associated clear cell renal cell carcinoma (ccRCC). (2021)

4555 Background: Inactivation of VHL leads to aberrant stabilization and accumulation of HIF-2α, which drives tumor growth. Patients (pts) with VHL disease are at risk for ccRCC, pancreatic neuroendocrine tumors (pNETs), and hemangioblastomas. Repeated surgeries are often needed to control ccRCC and other VHL disease manifestations. Prior results of this ongoing open-label phase 2 study (NCT03401788) showed activity with belzutifan in VHL disease. Updated results are presented. Methods: Adults with germline VHL alterations, measurable and localized/nonmetastatic ccRCC, no prior systemic anticancer therapy, and ECOG PS 0 or 1 received belzutifan 120 mg once daily until progression, intolerable toxicity, or decision to withdraw. The primary end point is ORR of VHL-associated ccRCC tumors per RECIST v1.1 by independent review committee (IRC). Secondary end points include DOR, time to response (TTR), PFS, and safety. Results: As of June 1, 2020, 61 pts enrolled. Most pts (82%) had ECOG PS 0, and the median number of prior tumor reduction procedures (eg, partial nephrectomy, craniotomy, radiation therapy) per pt was 5 (range, 0-15). Lesions outside the kidney (non-RCC tumors) evaluable by IRC included pNETs (33%) and CNS hemangioblastomas (82%). Median follow-up was 69 wk (range, 18-105), median duration of treatment was 68 wk (range, 8-105), and 56 pts (92%) remain on therapy. There were 22 confirmed responses (ORR, 36% [95% CI, 24-49]) and 7 (11%) unconfirmed responses (documented at 1 time point, to be confirmed at subsequent time point); all were PRs. In pts with confirmed PR, median DOR was not reached (range, 12+ to 62+ wk), median TTR was 31 wk (range, 12-61), and 56 pts (92%) had some reduction in the sum of all target lesion diameters. PFS rate at 52 wk was 98% (95% CI, 89-100). For non-RCC tumors, ORR was 80% (16/20; 1 CR) in pNETs and 32% (16/50; 1 CR) in CNS hemangioblastomas. Of 16 pts with evaluable retinal hemangioblastomas at baseline, 11 (69%) showed improvement per IRC. In those 16 pts, 29 eyes were monitored for retinal hemangioblastomas: 16 eyes (55%) showed improvement, 12 (41%) were stable, and no evaluation was available for 1 eye (3%). All 61 pts (100%) had at least one AE. The most common all-cause AE was anemia (90%), which is considered an on-target toxicity. Treatment-related AEs (TRAE) were reported by 60 pts (98%), and 8 pts (13%) had a grade 3 TRAE. No pts had grade 4/5 TRAEs. One pt discontinued treatment because of a TRAE (grade 1 dizziness). Conclusions: Belzutifan demonstrates clinical benefit and has a favorable safety profile in patients with VHL disease–associated ccRCC, pNETs, and hemangioblastomas. Clinical trial information: NCT03401788.
Abstract P249: Moderate-to-Severe Depression Symptoms Are Associated With Poorly Controlled Glucose Levels in Persons With Type 2 Diabetes Mellitus (2023)

Objective: To investigate whether the severity of depression symptoms is associated with poor long-term control of plasma glucose levels in individuals with type 2 diabetes. Methods: Electronic health record [EHR] data of 2842 individuals with mental illness enrolled in the Penn State Clinical Assessment and Rating Evaluation System [PCARES] registry were used. Demographics, body mass index [BMI], baseline type 2 diabetes mellitus [T2DM] status and all available glucose labs were extracted from the EHR. The nine-item patient health questionnaire [PHQ-9] was used to determine baseline depression symptoms. PHQ-9 scores greater than/equal to 10 indicated moderate-to-severe depression symptoms, whereas scores less than 10 indicated none-to-mild depression symptoms. While the baseline glucose measurement had to be within ± 90 days of the baseline PHQ-9 date, longitudinal glucose measurements had to be on or after this date and within one year of the second follow-up glucose lab test date. Each glucose lab test had to be within one year of the preceding lab test. There were 917 individuals that met the criteria for baseline and follow-up glucose measurements and contributed to the effective study sample. Linear mixed-effects models were used to assess the association between baseline depression and changes in glucose levels, with a focus on persons with baseline diabetes. Results are reported as beta-coefficients (standard errors [SE]) and P -values. Results: The study sample included 917 individuals, with 65% females (596 of 917) and 85% (780 of 917) Non-Hispanic Caucasians. The mean (SD) age, PHQ-9 score, BMI, and glucose were 47.7 (16.9) years, 12.0 (7.1), 31.6 (8.6) Kg/m 2, and 115.9 (48.8) mg/dl, respectively. At baseline, 62.0% had moderate-to-severe depression (569 of 917), and 37.1% of persons had T2DM (341 of 917). Among individuals without T2DM, there was no association between the severity of depression symptoms and follow-up glucose levels with a beta (SE) of 1.1 (1.1) and P =0.32. Among persons with T2DM (N=341), there was an average increase in glucose levels by 2.8 (2.1) mg/dl, P =0.17, per year of follow-up. When stratified by the severity of depression symptoms, individuals with moderate-to-severe depression symptoms had a significant increase in glucose levels at 6.2 (2.7) mg/dl, P =0.02, per year of follow-up, indicative of poor control of blood glucose levels. Whereas, among persons with none-to-mild depression symptoms, blood glucose levels showed a non-significant decline at 2.6 (3.4) mg/dl, P =0.45, per year of follow-up. Conclusions: In this clinic-based sample of persons with mental illness, moderate-to-severe depression symptoms were associated with significantly increasing blood glucose levels among persons with co-morbid T2DM. Our findings underscore integrated physical and mental healthcare services and routine depression screening among persons with diabetes.
Gene expression signature of putative Cancer Stem Cells in Retinoblastoma Y79 cell line (2013)

Rohini Nair1, Murali Mohan Sagar Balla2, Imran Khan3, Ravi Kiran Reddy Kalathur3, Paturu Kondaiah3, Santosh Honavar4, Mohammad Ali4 and Geeta Vemuganti1 1 School of Medical Sciences, University of Hyderabad, Hyderabad, India 2 Ophthalmic Pathology Laboratory, L.V.Prasad Eye Institute, Hyderabad, India 3 Molecular Reproduction, Development and Genetics, Indian Institute of Science, Bangalore, India 4 Ophthalmic and Facial Plastic Surgery, Orbit and Ocular Oncology, L.V.Prasad Eye Institute, Hyderabad, India
Substrate-Binding Phosphine Ligand in Enantioselective Hydroformylation<b /> (2010)

The authors report an enantioselective hydroformylation of allylic amines using a tricyclic ligand. The strategy of using a catalytic ligand to bind both the substrate and the transition-metal catalyst has only recently been employed by the authors (J. Am. Chem. Soc. 2008, 130, 9210) as well as by the Breit group (e.g., ­Angew. Chem. Int. Ed. 2008, 47, 7346). The main benefits of this strategy versus alternative enantio­selective rhodium-catalyzed hydroformylations are the higher regioselectivity and reactivity under milder conditions.
Accurate human body reconstruction for volumetric video (2021)

In this work, we enhance a professional end-to-end volumetric video production pipeline to achieve high-fidelity human body reconstruction using only passive cameras. While current volumetric video approaches estimate depth maps using traditional stereo matching techniques, we introduce and optimize deep learning-based multi-view stereo networks for depth map estimation in the context of professional volumetric video reconstruction. Furthermore, we propose a novel depth map post-processing approach including filtering and fusion, by taking into account photometric confidence, cross-view geometric consistency, foreground masks as well as camera viewing frustums. We show that our method can generate high levels of geometric detail for reconstructed human bodies.
Commentary Soluble RAGE: a hot new biomarker for the hot joint? (2005)

The receptor for advanced glycation endproducts (RAGE) interacts with distinct ligand families linked to the inflammatory response. Studies in animal models suggest that RAGE is upregulated in the inflamed joint and that blockade of the receptor, using a ligand decoy soluble form of RAGE (sRAGE), attenuates joint inflammation and expression of inflammatory and tissuedestructive mediators. In this issue of Arthritis Research &amp;amp; Therapy, Rille Pullerits and colleagues reported that plasma levels of sRAGE were reduced in subjects with rheumatoid arthritis compared with healthy controls or subjects with non-inflammatory joint disease. These findings suggest the possibility that levels of sRAGE might be a biomarker of inflammation. Not resolved by these studies, however, is the intriguing possibility that endogenously higher levels of sRAGE might be linked to a lower incidence of arthritis or to the extent of inflammation. Nevertheless, although ‘cause or effect ’ relationships may not be established in this report, fascinating insights into RAGE, inflammation and human arthritis emerge from these studies.
Quadrupole trap control circuit for laser desorption mass spectrometry of levitated microparticles (1995)

An electronic control system for laser desorption mass spectrometry of a levitated single microparticle in a quadrupole trap is described. This circuit provides appropriate low-frequency ac and dc voltages for microparticle levitation and switches them to ground prior to laser desorption, enabling the trap to store and mass analyze the laser-desorbed ions.
Machine Learning for Improved Availability of the SNS Klystron High Voltage Converter Modulators (2021)

Beam availability has increased at the SNS, however, the targeted availability is greater than 95 %, while the SNS has failed to meet lower targets in the past. The HVCM used to power the linac klystrons have been one source of lost beam time and was chosen to explore using AI/ML techniques to improve reliability. Among the possibilities being explored are automating the tuning of HVCMs and predicting component failures such as capacitor aging, rectifier assemblies containing hundreds of diodes, and insulating oil degradation. The methodology pursued includes data cleaning, de-noising, post-analysis data labeling, and machine learning model development. We explore using Long Short-Term Memory and autoencoders for anomaly detection and prognostication used to schedule maintenance. We evaluate the use of model regularizers and constraints to improve the performance of the model and investigate methods to estimate the uncertainty of the models to provide a robust prediction with statistical interoperability. This paper describes the operational experience and known failures of the HVCMs and the proposed ML methodology and the preliminary results of training the AI/ML algorithms.
ChemInform Abstract: Novel Asymmetric Synthesis of an Indolizidine Alkaloid, (+)‐Lentiginosine, Employing Highly Stereoselective Hydrogenation of α‐Hydroxypyrrolidine. (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nonadiabatic interaction of a propagating wave packet with localized parametric pumping (2001)

The interaction of a propagating wave packet (carrier frequency omega, wave number k) with nonadiabatic parametric pumping, localized in a region of size the order of the carrier wavelength L approximately lambda=2pi/k, is studied experimentally in a system of dipolar spin waves in a ferrite film. It is shown that the three-wave parametric interaction omega+omega(')=omega(p) leads to the formation of both contrapropagating (k(')=-k) and copropagating (k(')=k) idle wave packets of carrier frequency omega('). A system of equations derived for the packet envelopes gives a quantitative description of the observed random modulation of the output signal caused by the interference of the input and copropagating idle wave packets.
Changes in the gut microbiome associated with liver stiffness improvement in nonalcoholic steatohepatitis (2022)

Longitudinal changes in the gut microbiota are observed in adults with NASH and clinical improvement and represent a shift toward a healthy microbiome.