gebhart/patrepeval huggingface dataset:
Optimisation of a Pump-Controlled Hydraulic System using Digital Displacement Pumps (2021)

When electrifying working machines, energy-efficient operation is key to maximise the use of the limited capacity of on-board batteries. Previous research indicate high energy savings by means of component and system design. In contrast, this paper focuses on how to maximise energy efficiency by means of both design and control optimisation. Simulation-based optimisation and dynamic programming are used to find the optimal electric motor speed trajectory and component sizes for a scooptram machine equipped with pump control, enabled by digital displacement pumps with dynamic flow sharing. The results show that a hardware configuration and control strategy that enable low pump speed minimise drag losses from parasitic components, partly facilitated by the relatively high and operation point-independent efficiencies of the pumps and electric motor. 5–10% cycle energy reductions are indicated, where the higher figure was obtained for simultaneous design and control optimisation. For other, more hydraulic-intense applications, such as excavators, greater reductions could be expected.
Sichere IT ohne Schwachstellen und Hintertüren (2020)

Unsere zunehmende Abhängigkeit von Informationstechnik erhöht kontinuierlich die Safety- und Security-Anforderungen bei deren Einsatz. Ein zentrales Problem hierbei sind Schwachstellen von Hard- und Software. Marktkräfte konnten diese Situation bislang nicht grundsätzlich beheben. Eine Gegenstrategie sollte deshalb folgende Optionen erwägen: (1) private und staatliche Förderung offener und sicherer IT‑Produktion, (2) Verbesserung der souveränen Kontrolle bei der Produktion aller kritischen IT‑Komponenten innerhalb eines Wirtschaftsraumes sowie (3) verbesserte und durchgesetzte Regulierung. Dieser Beitrag analysiert Vor- und Nachteile dieser Optionen. Es wird vorgeschlagen, die Sicherheit der Schlüsselkomponenten einer Lieferkette durch weltweit verteilte, offene und ggf. mathematisch bewiesene Komponenten zu gewährleisten. Der beschriebene Ansatz erlaubt die Nutzung existierender und neuer proprietärer Komponenten.
Electrochemical and Homogeneous Proton-Coupled Electron Transfers:  Concerted Pathways in the One-Electron Oxidation of a Phenol Coupled with an Intramolecular Amine-Driven Proton Transfer (2006)

Proton-coupled electron transfers currently attract considerable attention in view of their likely involvement in many natural processes. Electrochemistry, through techniques such as cyclic voltammetry, is an efficient way of investigating the reaction mechanism of these reactions, and deciding whether proton and electron transfers are concerted or occur in a stepwise manner. The oxidation of an ortho-substituted 4,6-di (tert-butyl)-phenol in which the phenolic hydrogen atom is transferred during the reaction to the nitrogen atom of a nearby amine is taken as illustrative example. A careful analysis of the cyclic voltammetric responses obtained with this compound and its OD derivative allows, after estimation of the various thermodynamic parameters, ruling out the occurrence of the square scheme mechanism involving the proton-electron and electron-proton sequences. Simulation and comparison of the rate constant and H/D kinetic isotope effect with theoretical predictions show that the experimental value of the preexponential factor is ca. 1 order of magnitude larger than the theoretical value. Detailed calculations suggest that an electric field effect is responsible for this discrepancy.
Towards millions of communicating threads (2016)

We explore in this paper the advantages that accrue from avoiding the use of wildcards in MPI. We show that, with this change, one can efficiently support millions of concurrently communicating light-weight threads using send-receive communication.
Incorporation of Palmitic Acid or Stearic Acid into Soybean Oils Using Enzymatic Interesterification (2016)

Incorporations of nature fatty acids which were palmitic acid and stearic acid into the end positions of soybean oils were done using sn-1,3 specific immobilised lipase from Rhizomucor miehei at different ratios in order to produce symmetrical triglycerides without changing the fatty acids at sn-2 position. The optimum ratio for the process was 25:75 w/w. There were 19.2% increase of SFA for P25 and 16% increase for S25 at the sn-1,3 positions. The research findings indicated that the structured lipids produced from enzymatic interesterification possessed a higher oxidative stability than soybean oil. The newly formed structured lipids (SUS type) could be good sources for various applications in food industry.
Superoptimized Memory Subsystems for Streaming Applications (2015)

Because main memory is many times slower than modern processor cores, deep, multi-level cache hierarchies are ubiquitous in computers today. Similarly, applications deployed on ASICs and FPGAs are often hindered by slow external memories. Therefore, to achieve good performance, hardware designers must optimize main memory usage. Unfortunately, this process is often labor intensive and fails to explore the full range of potential memory designs. To address this issue for applications expressed in a streaming manner, we show that it is possible to generate automatically a superoptimized memory subsystem that can be deployed on an FPGA such that it performs better than a general-purpose memory subsystem. Rather than explore only simple memory subsystems, our superoptimizer is capable of exploring extremely complex designs consisting of multi-level caches and other components. Finally, we show that it is possible to deploy applications with superoptimized memory subsystems with minimal additional effort while achieving significant performance improvements over a naive memory subsystem.
Valle Grande: Overture for Double String Orchestra (2015)

“Valle Grande: Overture for Double String Orchestra,” commissioned by the Eldorado High School Orchestra in Albuquerque NM, was premiered by the school's top two string orchestras, conducted by Ruth Striegel on May 3, 2016. It was inspired by a trip that the conductor and I and the students made to Valles Caldera National Preserve the previous September. When Ruth asked me to write a piece for her orchestras that was inspired by a place I loved in New Mexico, it coincided with the opening of the preserve. Since the Jemez Mountains are my favorite place in the state, I had often admired the expansive caldera—then private land—from the highway. But getting a guided tour of it with the students was a peak experience—a lovely confluence of old and new.
Detection of Tubulointerstitial Nephritis Antigen (TIN-ag) in Lewis Rat (1997)

Tubulointerstitial nephritis antigen (TIN-ag) is a recently described basement membrane component reactive with autoantibodies in some forms of autoimmune mediated tubulointerstitial nephritis. Immunofluorescence studies using polyclonal and monoclonal antibodies have indicated a restrictive tissue distribution for TIN-ag, with the site of most prominent expression the kidney tubular basement membrane. However, Lewis rat does not demonstrate any immunoreactivity for TIN-ag and does not develop tubuloinsterstitial nephritis after injection of tubular basement membrane material. As TIN-ag would appear to be a molecule of biological significance, experiments were designed to explore the presence or absence of this macromolecule in the Lewis rat model. Southern blotting of Lewis rat genomic DNA revealed the presence of gene sequences corresponding to TIN-ag. RTPCR analysis of Lewis rat kidney cortex total RNA illustrated the expression of a TIN-ag gene product. Western blotting demonstrated the presence of TIN-ag protein forms in kidney cortical homogenates of Lewis rat. The data suggest either extensive epitope masking or expression polymorphism of TIN-ag in the Lewis rat.
Data from Targeting N-linked Glycosylation for the Therapy of Aggressive Lymphomas (2023)

&lt;div&gt;Abstract&lt;p&gt;Diffuse large B-cell lymphoma (DLBCL) can be subdivided into the activated B-cell (ABC) and germinal center B cell–like (GCB) subtypes. Self-antigen engagement of B-cell receptors (BCR) in ABC tumors induces their clustering, thereby initiating chronic active signaling and activation of NF-κB and PI3 kinase. Constitutive BCR signaling is essential in some GCB tumors but primarily activates PI3 kinase. We devised genome-wide CRISPR–Cas9 screens to identify regulators of IRF4, a direct transcriptional target of NF-κB and an indicator of proximal BCR signaling in ABC DLBCL. Unexpectedly, inactivation of N-linked protein glycosylation by the oligosaccharyltransferase-B (OST-B) complex reduced IRF4 expression. OST-B inhibition of BCR glycosylation reduced BCR clustering and internalization while promoting its association with CD22, which attenuated PI3 kinase and NF-κB activation. By directly interfering with proximal BCR signaling, OST-B inactivation killed models of ABC and GCB DLBCL, supporting the development of selective OST-B inhibitors for the treatment of these aggressive cancers.&lt;/p&gt;Significance:&lt;p&gt;DLBCL depends on constitutive BCR activation and signaling. There are currently no therapeutics that target the BCR directly and attenuate its pathologic signaling. Here, we unraveled a therapeutically exploitable, OST-B–dependent glycosylation pathway that drives BCR organization and proximal BCR signaling.&lt;/p&gt;&lt;/div&gt;
Development of an Active Twist Rotor for Wind: Tunnel Testing (NLPN97-310 (1998)

The development of the Active Twist Rotor prototype blade for hub vibration and noise reduction studies is presented in this report. Details of the modeling, design, and manufacturing are explored. The rotor blade is integrally twisted by direct strain actuation. This is accomplished by distributing embedded piezoelectric fiber composites along the span of the blade. The development of the analysis framework for this type of active blade is presented. The requirements for the prototype blade, along with the final design results are also presented. A detail discussion on the manufacturing aspects of the prototype blade is described. Experimental structural characteristics of the prototype blade compare well with design goals, and preliminary bench actuation tests show lower performance than originally predicted. Electrical difficulties with the actuators are also discussed. The presented prototype blade is leading to a complete fully articulated four-blade active twist rotor system for future wind tunnel tests.
Docking Phospholipase A <sub>2</sub> on Membranes Using Electrostatic Potential-Modulated Spin Relaxation Magnetic Resonance (1998)

A method involving electron paramagnetic resonance spectroscopy of a site-selectively spin-labeled peripheral membrane protein in the presence and absence of membranes and of a water-soluble spin relaxant (chromium oxalate) has been developed to determine how bee venom phospholipase A2 sits on the membrane. Theory based on the Poisson-Boltzmann equation shows that the rate of spin relaxation of a protein-bound nitroxide by a membrane-impermeant spin relaxant depends on the distance (up to tens of angstroms) from the spin probe to the membrane. The measurements define the interfacial binding surface of this secreted phospholipase A2.
Risk factors associated with tobacco, alcohol and drug use among adolescents attending secondary school in three cities from Argentina (2017)

Tobacco, alcohol and drug use starts at an early age. It is important to identify risk factors associated with initiation. In 2014, a survey was conducted among students attending first year of secondary schools in Buenos Aires, Córdoba, and Tucumán. A total of 3172 students completed the survey (42% were girls); their mean age was 12.8 years old. Findings showed that 10% had smoked; 32% had consumed alcohol; 17% had a heavy drinking episode in the past month; and 8% had used at least one illegal drug once in their lifetime. A high sensation seeking index was associated with the use of tobacco (odds ratio [OR]: 4.25, 95% confidence interval [CI]: 2.2-8.1), alcohol (OR: 5.56, 95% CI: 3.73-8.31), and marijuana, coca paste or cocaine, (OR: 11.73, 95% CI: 5.81-23.69). Having friends who smoke or drink was associated with tobacco (OR: 12.6, 95% CI: 7.8-20.5) and alcohol use (OR: 5.17, 95% CI: 4.15-6.40). Having permissive parents in terms of media use was associated with tobacco use (OR: 3.7, 95% CI: 2.1-6.5), and perceiving a low parental support and control (OR: 3.02, 95% CI: 1.40-6.52) was associated with marijuana, coca paste and cocaine use.
556 PB 371 EFFECTS OF SUBLETHAL HEAT STRESS 0N ENDODOPMANCY AND ECODORMANCY OF PEACH AND HYBRID POPLAR (1994)

Sublethal heat stress has been shown to decrease or eliminate deep supercooling of flower buds in woody plants and to release plants from endodormancy. Experiments were conducted to characterize the effect of heat stress on endodormancy and ecodormancy in peach (cv Loring) and two hybrid poplars. Protein synthesis (de novo) and patterns of protein expression were also monitored. In order to determine optimum treatment temperatures, shoots, collected September-March, were exposed to a range of temperatures (35-60 C) under wet or dry conditions for 1-6 h. Shoots were then placed in the greenhouse and cumulative budbreak was monitored over 4 weeks. Samples of bud and bark tissues were collected during and up to 72 h after heat treatment for SDS-PAGE analysis. Data indicate: 1) twigs must be immersed in water for the heat treatments to be effective; 2) heat treatments resulted in a release from endodormancy and a decrease in thermal units needed for budbreak during ecodormancy; 3) 40 C for 2-4 h was optimum in fall and late winter whereas 45 C was the optimum temperature to induce budbreak in midwinter; 4) optimum temperature for peach floral buds (37.5 C/2h) was lower than for vegetative buds (40 C/4h), and 5) heat treatments also decreased cold hardiness. Protein synthesis decreased significantly following heat treatment but was significantly greater than controls (room temp) 24-48 h after heat treatment.
Na+/Li+ Exchange in One-Dimensional Tunnels of the Framework Structure (1995)

Abstract Metastable Li-titanogallate has been obtained by substituting Li+ ions for Na+ ions of NaxTi2−xGa4+xO10 (x = 0.85) in molten LiNO3 at 450 °C. Na+ ions in one-dimensional tunnels of the framework structure have been practically exchanged by Li+ ions. Rietveld fitting of X-ray diffraction profile has clarified that the framework stucture has been retained but reasonably deformed by the ion exchange reaction.
Evolution of Patient-Controlled Analgesia: From Intravenous to Sublingual Treatment (2016)

Opioid administration delivered intravenously (IV) by patient-controlled analgesia (PCA) devices has been an important development in addressing insufficient management of acute pain in the postsurgical setting. However, IV PCA has several disadvantages, including operator error, risk of patient exposure to analgesic gaps, IV line patency issues, and risk of catheter-related infection, all of which contribute to the total cost of care. Morphine, the most commonly used opioid in IV PCA, has a relatively slow onset of analgesia, which may leave patients with inadequate initial pain control and at risk of opioid dose-stacking. Sufentanil is an opioid with no major active metabolites and a rapid onset of analgesia. The sufentanil sublingual tablet system (SSTS) with a 20-minute lockout and other safety features is a novel noninvasive PCA system in development for on-demand relief of moderate to severe acute pain in the hospital setting. Data from phase 3 trials of the use of SSTS after elective major open abdominal and orthopedic surgery show that analgesia is rapidly achieved, with a longer mean interdosing interval compared with IV PCA morphine (81 vs 47 minutes) and a high level of patient and nurse satisfaction. These data suggest that SSTS may also aid in the avoidance of some of the pitfalls inherent with IV PCA, which may help reduce hospital costs associated with IV PCA-related issues. This article describes the evolution, benefits, issues, and costs associated with IV PCA and reviews data from preclinical studies of sufentanil through SSTS phase 3 trials.
Optimization and Learning Algorithms for Stochastic and Adversarial Power Control (2019)

Power control in wireless networks is a well-studied problem. However, recently it has been demonstrated that significant throughput gains can be achieved using data-driven online learning algorithms, supported by a cloud computing infrastructure. In this paper, we provide theoretical guarantees for such algorithms. In particular, we consider two variants of the problem: one which emphasizes long-term throughput and the other which emphasizes robust short-term throughput. The first problem reduces to solving a convex optimization problem with noisy, stochastic measurements while the second one is an online optimization problem where an adversary chooses the reward functions. We provide stochastic and online gradient descent methods customized for the power control problem and establish their convergence analysis. We show that in both cases, the total regret over a time horizon T grows sublinearly at rate O(√T) for suitable choices of algorithms and algorithm parameters.
Synthesis of Pyrazoles by 1,3‐Dipolar Cycloaddition under Aqueous Micellar Catalysis (2022)

Abstract Ethyl diazoacetate (EDA), which is easily prepared from ethyl glycinate and NaNO 2 , reacts in situ with alkynes in a water micelle environment without organic solvent to form pyrazoles. The reaction is pH dependent, as in the presence of protic catalysis (H 2 SO 4 4 %, pH 3.5) a mixture of 3,5‐ and 4,5‐disubstituted pyrazoles was obtained, while, at pH 5.5, only the 3,5‐disubstituted isomer was obtained. The presence of the surfactant TPGS‐750‐M was crucial to secure clean crude reaction mixtures and high yields of the products. The same protocol was successfully applied to the synthesis of substituted pyrazolines.
Data from Aurora A Inhibitor TAS-119 Enhances Antitumor Efficacy of Taxanes &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt;: Preclinical Studies as Guidance for Clinical Development and Trial Design (2023)

&lt;div&gt;Abstract&lt;p&gt;TAS-119 is a novel orally active, selective inhibitor of Aurora kinase A identified as a clinical candidate for efficacy testing in combination with taxanes. &lt;i&gt;In vitro&lt;/i&gt;, TAS-119 enhanced cell growth inhibition of paclitaxel in multiple human cancer cell lines derived from various tissues, including paclitaxel-resistant cell lines. Interestingly, TAS-119 did not enhance paclitaxel antitumor activity in normal lung diploid fibroblast cell lines WI-38 and MRC5. &lt;i&gt;In vivo&lt;/i&gt;, TAS-119 enhanced the antitumor efficacy of paclitaxel and docetaxel in multiple models at doses inhibitory to Aurora A in tumors. Moreover, the drug combination was well tolerated, and TAS-119 did not exaggerate clinically documented side effects of taxanes, neutropenia and neurotoxicity, in rats. The same TAS-119 concentration enhanced the cell growth inhibitory activity of three clinically approved taxanes, paclitaxel, docetaxel, and cabazitaxel. The degree of enhancement calculated as fold of change of the IC&lt;sub&gt;50&lt;/sub&gt; value for each taxane was almost the same among the three taxanes. We conducted &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; experiments to develop an optimized combination therapy regimen for TAS-119 with paclitaxel/docetaxel. Using &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt; models, we tested the drug administration order for TAS-119 combined with paclitaxel and the TAS-119 treatment duration. The best regimen in preclinical models was combining paclitaxel or docetaxel treatment with 4 days of TAS-119 dosing, which was initiated on the same day as the paclitaxel or docetaxel administration or one day later. This information provided guidance for the design of a clinical trial of TAS-119 and paclitaxel or docetaxel combination.&lt;/p&gt;&lt;/div&gt;
ANALYSIS OF THE IMPACT OF HLA-DR MATCHING ON PRIMARY CADAVERIC RENAL TRANSPLANTS DURING THE MOLECULAR TYPING ERA: IMPROVED SURVIVAL AND REJECTION FREE INTERVAL. (2000)

Chin, L. Thomas; Lorentzen, David; Heisey, Dennis; Burlingham, William; Sollinger, Hans; Pirsch, John Author Information
Coupling between cerebral blood flow and cerebral blood volume: Contributions of different vascular compartments (2019)

A better understanding of the coupling between changes in cerebral blood flow (CBF) and cerebral blood volume (CBV) is vital for furthering our understanding of the BOLD response. The aim of this study was to measure CBF-CBV coupling in different vascular compartments during neural activation. Three haemodynamic parameters were measured during a visual stimulus. Look-Locker flow-sensitive alternating inversion recovery was used to measure changes in CBF and arterial CBV (CBV<sub>a</sub> ) using sequence parameters optimized for each contrast. Changes in total CBV (CBV<sub>tot</sub> ) were measured using a gadolinium-based contrast agent technique. Haemodynamic changes were extracted from a region of interest based on voxels that were activated in the CBF experiments. The CBF-CBV<sub>tot</sub> coupling constant α<sub>tot</sub> was measured as 0.16 ± 0.14 and the CBF-CBV<sub>a</sub> coupling constant α<sub>a</sub> was measured as 0.65 ± 0.24. Using a two-compartment model of the vasculature (arterial and venous), the change in venous CBV (CBV<sub>v</sub> ) was predicted for an assumed value of baseline arterial and venous blood volume. These results will enhance the accuracy and reliability of applications that rely on models of the BOLD response, such as calibrated BOLD.
Laparoscopy/New Technology (2009)

No AccessJournal of UrologyAdult Urology1 Jan 2010Laparoscopy/New Technology Jeffrey A. CadedduM.D. Jeffrey A. CadedduJeffrey A. Cadeddu More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2009.09.051AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Laparoscopy/New Technology." The Journal of Urology, 183(1), p. 214 © 2010 by American Urological AssociationFiguresReferencesRelatedDetails Volume 183Issue 1January 2010Page: 214 Advertisement Copyright & Permissions© 2010 by American Urological AssociationMetricsAuthor Information Jeffrey A. Cadeddu More articles by this author Expand All Advertisement PDF downloadLoading ...
Supplementary Figure 3 from Intrinsic Breast Tumor Subtypes, Race, and Long-Term Survival in the Carolina Breast Cancer Study (2023)

&lt;p&gt;PDF file - 28K&lt;/p&gt;
Cardiac Tissue Engineering: A Clinical Perspective (2007)

Engineered myocardium may be used to repair myocardial defects. Although not clinically applicable yet, initial studies in rodents have demonstrated the feasibility of tissue engineering based myocardial repair in vivo. In order for restorative treatment to evolve into a functional treatment modality, tissue engineers have to generate human myocardium of sufficient size and with relevant contractile function to replace/repair myocardial defects. This requires the identification of a scalable and ideally autologous cardiomyocyte source as well as the development of strategies to overcome size limitations. We will further address pivotal issues pertaining to the allocation of suitable human cells for myocardial tissue engineering and discuss the translation of present myocardial tissue engineering concepts into preclinical, as well as clinical, trials.
Ethoxycarbonylmethylcopper (2001)

[35756-99-1] C4H7CuO2 (MW 150.65) InChI = 1S/C4H7O2.Cu/c1-3-6-4(2)5;/h2-3H2,1H3; InChIKey = AYQIUYSEGMJQFN-UHFFFAOYSA-N (reagent for improved yields of allylation of ethyl acetate2) Preparative Methods: by the reaction of Ethyl Lithioacetate and Copper(I) Iodide in THF as a heterogeneous pale yellow solution at −110 °C or as a light brown homogeneous solution at −30 °C. Handling, Storage, and Precautions: unstable above −30 °C; decomposes readily upon exposure to air or moisture. Use in a fume hood.