gebhart/patrepeval huggingface dataset:
Superconducting properties of YBa<sub>2</sub>Cu<sub>3</sub>O<sub>7−δ</sub>films deposited on commercial tape substrates, decorated with Pd or Ta nano-islands (2012)

To obtain an engineered surface for deposition of high-Tc superconductors, nanoscale modulations of the surface of the underlying LaMnO3 (LMO) cap layer is a potential source for generating microstructural defects in YBa2Cu3O7−δ (YBCO) films. These defects may improve the flux pinning and consequently increase the critical current density, Jc. To provide such nanoscale modulation via a practical and scalable process, palladium (Pd) or tantalum (Ta) nano-islands were deposited using dc-magnetron sputtering on the surface of the cap layer of commercial metal tape templates for second-generation wires. The size and density of these nano-islands can be controlled by changing sputtering conditions such as the power and deposition time. Compared to the reference sample grown on an untreated LMO cap layer, the YBCO films grown on the LMO cap layers with Pd or Ta nano-islands exhibited improved in-field Jc performance. Atomic force microscopy and transmission electron microscopy were used to assess the evolving size and density of the nano-islands.
Di(benzotriazol-1-yl)methanimine:  A New Reagent for the Synthesis of Tri- and Tetrasubstituted Guanidines (2000)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNEXTDi(benzotriazol-1-yl)methanimine: A New Reagent for the Synthesis of Tri- and Tetrasubstituted GuanidinesAlan R. Katritzky, Boris V. Rogovoy, Christophe Chassaing, and Vladimir VvedenskyView Author Information Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, Florida 32611-7200 [email protected]Cite this: J. Org. Chem. 2000, 65, 23, 8080–8082Publication Date (Web):October 21, 2000Publication History Received27 April 2000Published online21 October 2000Published inissue 1 November 2000https://pubs.acs.org/doi/10.1021/jo0006526https://doi.org/10.1021/jo0006526brief-reportACS PublicationsCopyright © 2000 American Chemical SocietyRequest reuse permissionsArticle Views1135Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amines,Guanidine,Mixtures,Molecular structure,Reagents Get e-Alerts
Activated Tissue-Resident CD47 Is a Proximate Promoter of Renal Ischemia Reperfusion Injury (2012)

Background: Renal ischemia-reperfusion injury (IRI) contributes to both delayed graft function and allograft rejection in the transplanted organ. Improved understanding of mechanisms responsible for IRI is essential for the development of therapeutic strategies. Thrombospondin-1 (TSP1) is a secreted protein produced in response to cellular stress and is the soluble ligand for the ubiquitously expressed cell-surface receptor CD47. The function of the TSP1/CD47 axis in IRI remains unexplored. This prompted us to evaluate the role of CD47 activation in renal IRI using CD47-/- mice, CD47-blocking antibody (Ab) in wild-type mice, and chimeric mice deficient in leukocyte or renal parenchymal CD47. Methods: Wild type (WT) C57BL/6 and CD47-/- (B6) male mice (8-10 wks old, n=8-12 per group) were subjected to bilateral renal IRI, with pedicle clamping for 22 minutes and analysis at 24 hours reperfusion. Mice were also lethally irradiated and rescued with CD47-/- or CD47+/+ bone marrow (BM). In additional experiments, WT mice were pre-treated with CD47-blocking Ab prior to IRI. Results: IRI significantly upregulated mRNA and protein expression of both TSP1 and its receptor CD47 in WT kidneys only. This was associated with substantially more renal damage as reflected by increased tubular injury scores (72% vs 22% tubular damage, p< 0.001), renal dysfunction (serum creatinine 2.75 vs 1.46mg/dl, p< 0.001), leukocyte infiltration (140±26 vs 53±12 neutrophils per hpf, p< 0.0001) and pro-inflammatory cytokine production (including interleukin-6, interleukin-1β and tumor necrosis factor α) in WT controls compared to CD47-/- mice. Caspase-3 expression and TUNEL staining was negligible following IRI in CD47-/- mice compared to significant upregulation in WT animals. Generation of the reactive oxygen species (ROS) hydrogen peroxide (detected via Amplex Red assay) and ROS-mediated protein modifications (quantified by 3-nitroytrosine levels) were both abrogated in CD47-/- mice, as was the induction of nitric oxide synthase (iNOS) mRNA. In addition, an increase in toll-like receptor-2 (TLR2) protein and mRNA expression following IRI was evident in WT but not in CD47-/- mice; however, upregulation of TLR4 was not significantly different. Analysis of chimeric mice demonstrated that CD47 expression on tubular epithelial cells plays a crucial role in IRI, as CD47-/- mice reconstituted with WT BM were similarly protected against tubular damage and functional renal impairment. Pre-treatment with CD47-blocking Ab down-regulated renal CD47 protein expression and subsequently protected WT mice from renal dysfunction and tubular damage compared to animals treated with isotype control. Conclusion: We have identified renal-associated CD47 as an important facilitator of programmed cell death and inflammation in IRI. These data imply that CD47 is fundamental to promoting renal IRI through multiple mechanisms, and blockade provides a novel therapeutic target to prevent or modify IR-mediated damage.
Methyl acetoacetate derivatisation for improving liquid chromatography analysis of short chain aldehydes and water sensitive and chiral aldehydes (2022)

The importance of aldehydes in a number of industries has been well established, and therefore there is a resulting need to effectively and accurately monitor them. We report the application of a methyl acetoacetate derivatisation reaction to enable the analysis of aldehydes by HPLC-UV. This derivatisation reaction has been compared to alternative derivatisation reactions with nitrophenylhydrazines, resulting preferable since it yielded a more intense signal of the compound of interest and less interfering peaks. The derivatisation reaction was then optimised and applied for the analysis of short chained aldehydes such as formaldehyde, acetaldehyde, propionaldehyde, butyraldehyde and isobutyraldehyde, investigating parameters such as sensitivity, linearity, accuracy, and precision. This strategy has been successfully deployed also for determination of formaldehyde in a 25% w/w sodium methoxide solution in methanol at a target level of 200 ppm. Finally, this derivatisation reaction has been adjusted to enable the development of a robust chiral analytical method for a water sensitive aldehyde.
A new der(1;7)(q10;p10) leading to a singular 1p loss in a case of glioblastoma with oligodendroglioma component (2013)

The combined 1p-/19q- deletions in oligodendrogliomas originate from translocation between both chromosomes. In the few cases of oligoastrocytomas and glioblastomas with an oligodendroglioma component (GBMO) where only 1p deletion was described, the origin remains unknown. We report the first case of GBMO, in which a single 1p deletion was detected and was linked to a translocation between chromosomes 1 and 7. Fresh surgical specimens were collected during surgery and the samples were used for cell culture, touch preparation smear slides (TP slides) and DNA extraction. Peripheral venous blood was also collected from the patient. G-banding using Trypsin and stained with Giemsa (GTG) banding and karyotyping were performed and 1p-/19q-, TP53, PTEN and c-MYC were analyzed by fluorescent in situ hybridization (FISH). Multicolor FISH (mFISH) and microsatellites analyses were also performed to complete the investigation. Three-dimensional quantitative FISH (3D-QFISH) of telomeres was performed on nuclei from TP slides and analyzed using TeloView(TM) to determine whether the 3D telomere profile as an assessment of telomere dysfunction and a characterization of genomic instability could predict the disease aggressiveness. An unbalanced chromosomal translocation was found in all metaphases and confirmed by mFISH. The karyotype of the case is: 50∼99,XXX, +der(1;7)(q10;p10),inc[47] The derivative chromosome was found in all 47 analyzed cells, but the number of derivatives varied from one to four. There was neither imbalance in copy number for genes TP53 and PTEN, nor amplification of c-MYC gene. We did not find loss of heterozygosity with analysis of microsatellite markers for chromosomes 1p and 19q in tumor cells. The 3D-telomere profile predicted a very poor prognostic and short-term survival of the patient and highlights the potential clinical power of telomere signatures as a solid biomarker of GBMO. Furthermore, this translocation between chromosomes 1 and 7 led to a singular 1p deletion in this GBMO and may generate the 1p and 7q deletions.
Differential effects of pentoxifylline on the production of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) by monocytes and T cells. (1992)

Pentoxifylline (PTX) is a methylxanthine compound known to inhibit the production of tumour necrosis factor-alpha (TNF-alpha) by monocytic cells. In this study, we found that PTX differentially regulates the production of TNF-alpha and interleukin-6 (IL-6). Indeed, PTX at high concentrations triggers the production of IL-6 but not of TNF-alpha by peripheral blood mononuclear cells (PBMC). Further experiments indicated that monocytes are responsible for this PTX-induced IL-6 production. When PBMC were stimulated with LPS, PTX was found to inhibit the secretion of TNF-alpha as well as the accumulation of TNF-alpha messenger RNA (mRNA). In contrast, no inhibitory effect was observed on the induction of IL-6. Similar results were obtained when PBMC were stimulated with OKT3 monoclonal antibody (mAb). In addition, the in vivo administration of PTX in transplant patients receiving the first dose of OKT3 allowed to decrease the systemic release of TNF-alpha but not of IL-6. Since monocytes represent a major source of TNF-alpha and IL-6 in these settings, additional experiments were performed in vitro on purified T cells stimulated with the CLB-T3/3, an anti-CD3 mAb which does not require the presence of accessory cells to activate T cells. In this system, PTX was found to inhibit the secretion of both TNF-alpha and IL-6 by T cells. We suggest that cAMP could be involved in these differential effects of PTX on production of TNF-alpha and of IL-6.
Aggregation Number in Water/<i>n</i>-Hexanol Molecular Clusters Formed in Cyclohexane at Different Water/<i>n</i>-Hexanol/Cyclohexane Compositions Calculated by Titration <sup>1</sup>H NMR (2017)

Upon titration of n-hexanol/cyclohexane mixtures of different molar compositions with water, water/n-hexanol clusters are formed in cyclohexane. Here, we develop a new method to estimate the water and n-hexanol aggregation numbers in the clusters that combines integration analysis in one-dimensional <sup>1</sup>H NMR spectra, diffusion coefficients calculated by diffusion-ordered NMR spectroscopy, and further application of the Stokes-Einstein equation to calculate the hydrodynamic volume of the clusters. Aggregation numbers of 5-15 molecules of n-hexanol per cluster in the absence of water were observed in the whole range of n-hexanol/cyclohexane molar fractions studied. After saturation with water, aggregation numbers of 6-13 n-hexanol and 0.5-5 water molecules per cluster were found. O-H and O-O atom distances related to hydrogen bonds between donor/acceptor molecules were theoretically calculated using density functional theory. The results show that at low n-hexanol molar fractions, where a robust hydrogen-bond network is held between n-hexanol molecules, addition of water makes the intermolecular O-O atom distance shorter, reinforcing molecular association in the clusters, whereas at high n-hexanol molar fractions, where dipole-dipole interactions dominate, addition of water makes the intermolecular O-O atom distance longer, weakening the cluster structure. This correlates with experimental NMR results, which show an increase in the size and aggregation number in the clusters upon addition of water at low n-hexanol molar fractions, and a decrease of these magnitudes at high n-hexanol molar fractions. In addition, water produces an increase in the proton exchange rate between donor/acceptor molecules at all n-hexanol molar fractions.
A fast wavelet-based algorithm for signal recovery from partial Fourier domain information (1998)

Signal reconstruction from the measurements of its Fourier transform magnitude remains an important and difficult problem that occurs in different areas in signal processing. Among all the approaches developed to solve this problem, the iterative transform algorithms are currently the most efficient. However, these algorithms suffer from major drawbacks such as stagnation, slow convergence, and high computational cost that limit their practical application. In this brief, we introduce a wavelet adaptation of the general iterative algorithm where the problem is decomposed into different resolution levels and the image is reconstructed following a coarse-to-fine strategy. We show that the proposed approach can significantly improve the performance of the existing algorithms while dramatically reducing their computational complexity.
A General Noise Resolution Model for Parking Occupancy Sensors (2012)

In this paper the authors address a challenging problem of predicting on-street parking occupancy based on sensors with occasionally missing data. These missing values are most likely not missing at random. However, the exact process behind it is unknown at the outset. For example, an entry in the data stream might read: “at time t, blockface b, which has capacity 20, has 18 working sensors, and of those working sensors 10 indicate that a parking space is occupied.” The challenge is to infer as accurately as possible the actual occupancy of blockface b, i.e. the occupancy of all parking spaces, including the ones with inoperative sensors. The fact that sensors are inoperative only occasionally allows us to learn a demand model and a sensor noise model jointly, and use this to “fill in the blanks” in the best possible way. The authors introduce a series of sensor noise models of increasing complexity that are suited for several sensor characteristics. Cross-validation allows the selection of the suitable model for a particular application. The sensor noise models introduced are flexible and can be combined with any probabilistic model for demand and hence have a very wide applicability. In our demonstration application the authors find that sensors are more likely to be inoperative when parking spaces are empty, in particular during busy traffic periods. This supports the hypothesis that drive-by-traffic is an important source of noise for the sensor. Compared to baseline methods based on a missing-at-random assumption our method gives better predictive performance and avoids a systematic bias in the inferred occupancies.
Supplementary Figure S2 from Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple &lt;i&gt;PIK3CA&lt;/i&gt; Mutations (2023)

&lt;p&gt;Breakdown of the different tumor types among double-PIK3CA mutant samples based on their clonality and cis/trans status.&lt;/p&gt;
Characterizing Water Transport Properties of Hydrocarbon Block Copolymer Proton Exchange Membranes (2013)

Abstract not Available.
Genome-wide RNAi screen discovers functional coupling of alternative splicing and cell cycle control to apoptosis regulation (2010)

Comment on: Moore MJ, et al. Cell 2010; 142:625-36.
Effects of Feeding Zinc, Manganese, and Copper Amino Acid Complexes and CobaltGlucoheptonate to Dairy Replacement Heifers on Claw Disorders (2005)

Five hundred seventy-two Holstein replacement heifers were fed a control diet or control diet plus complex trace minerals (CTM), which included 360 mg zinc/d, 200 mg manganese/d, and 125 mg copper/d from amino acid complexes and 12 mg cobalt/d from cobalt glucoheptonate. Dietary treatments were fed from 12 mo of age until 1 mo prepartum. Heifer claws were examined at 12 mo of age, 1 mo prepartum, and 2 mo postpartum. All claws disorders were identified and scored for severity on a scale of 1 = mild to 3 = severe. A claw disorder incidence and severity index (CIS) was calculated by multiplying, for each disorder, number of zones affected in each claw by average severity score of the disorder by 10. Heifers with claw disorders at 12 mo of age or at 1 mo prepartum had increased odds (P≤0.05) of developing claw disorders at 2 mo postpartum. Supplementing growing heifers with CTM increased (P≤0.05) CIS for sole hemorrhages and tended to increase (P≤0.15) CIS for claw disorders and heel erosion at 1 mo prepartum. Compared with control heifers, heifers fed CTM during rearing had a lesser (P≤0.05) CIS for white line separation and tended to have a lesser (P≤0.15) CIS for overall claw disorders and sole ulcers at 2 mo postpartum. In conclusion, presence of claw disorders during rearing increased risk of heifers developing claw disorders during lactation. Feeding CTM to heifers did not reduce incidence of claw disorders during rearing, but reduced incidence of claw disorders in early lactation.
Incorporating Beam Diagnostics Into UV Laser Delivery Systems (1988)

Optimum performance of a laser beam delivery system can generally be achieved only if key parameters are well known and controlled in real time or, at least, quasi-real time. Parameters of importance in typical applications of excimer lasers include energy delivered per pulse, size and shape of the beam, distribution of intensity over the beam&apos;s cross section, and the instantaneous and average location of the beam with respect to a target. The stability of each of these parameters over time is also of great importance. To maximize repeatability and uniformity of the laser system&apos;s performance, diagnostic measurement equipment should be integrated into the laser and beam delivery system itself. To maximize reliability of the measurement, it should be traceable to NBS standards. In this paper, selected techniques for accomplishing the desired diagnostic measurements are described briefly and hardware implications of incorporating diagnostic subsystems into typical beam delivery systems are discussed.
<scp>d</scp>,<scp>l</scp>-<i>S</i>-Methyllipoic Acid Methyl Ester, a Kinetically Viable Model for S-Protonated Lipoic Acid as the Oxidizing Agent in Reductive Acyl Transfers Catalyzed by the 2-Oxoacid Dehydrogenase Multienzyme Complexes (1998)

D,L-S(6,8)-Methyllipoic acid methyl ester triflate salt (D,L-S-methyllipoic acid methyl ester) was synthesized as a model for S-protonated lipoic acid, suggested to be the active form of lipoic acid in the reductive acylation catalyzed by the E1 and E2 enzymes of the 2-oxoacid dehydrogenase multienzyme complexes by a previous model [Chiu, C. C., Chung, A., Barletta, G., and Jordan, F. (1996) J. Am. Chem. Soc. 118, 11026-11029]. While in that earlier study lipoic acid could only trap only the enamine/C2 alpha-carbanion intermediate in an intramolecular model, and with the assistance of mercury compound to shift the equilibrium to the products, D,L-S-methyllipoic acid methyl ester could trap the enamine derived from 2-alpha-methoxybenzyl-3,4,5-trimethylthiazolium salt in an intermolecular reaction in the absence of a mercury compound, and with a rate constant of 6.6 x 10(4) M-1 S-1. A tetrahedral adduct at the C2 alpha-position formed between the enamine and D,L-S-methyllipoic acid methyl ester was isolated and characterized. The reaction likely takes place by two-electron nucleophilic attack, since no evidence was found for C2 alpha-linked homodimers, expected from a free-radical mechanism. The results suggest that, in the reductive acyl transfer, there is nucleophilic attack by the enamine at one of the sulfur atoms of the lipoic acid [probably at S8, according to Frey, P. A., Flournoy, D. S., Gruys, K., and Yang, Y. S. (1989) Ann. N.Y. Acad. Sci. 373, 21-35], while there is concomitant electrophilic catalysis by a proton juxtaposed at S6 via a general acid catalyst located on the E1 enzyme. Oxidation of the enamine derived from C2 alpha-hydroxybenzyl-3,4,5-trimethylthiazolium salt by D,L-S-methyllipoic acid methyl ester was also deduced on the basis of the formation of 2-benzoylthiazolium ion as a major product; however, the tetrahedral intermediate could not be detected. Oxidation of the enamine by D,L-S-methyllipoic acid methyl ester can take place with either an ether or an alcohol at the C2 alpha position of the enamine.
Effect of atrial fibrillation on outcomes in patients with anterior circulation occlusion stroke receiving endovascular therapy (2023)

Despite their older age, AF patients achieved similar outcomes as non-AF patients with anterior circulation occlusion treated with endovascular therapy.
Dynamic reconfiguration of Distributed Arithmetic designs (2006)

We present a design space exploration for applications using runtime reconfigurable FPGAs. The studied example is a mechatronic control system which changes between different controller tasks at runtime. For each task we implement six alternative distributed arithmetic designs with area/computation time trade-offs. Values are estimated and later on compared to synthesis results. For exchanging controllers at runtime we propose three different mappings to the FPGA. Given the application characteristics and the reconfiguration speed of the target FPGA, our analysis derives the optimal selection of the alternative task implementations and the corresponding mapping.
Effect of PEO−PPO−PEO Triblock Copolymers on Structure and Stability of Phosphatidylcholine Liposomes (1999)

The interactions of five poly(oxyethylene)−poly(oxypropylene)−poly(oxyethylene) (PEO−PPO−PEO), Pluronic, copolymers and phosphatidylcholine liposomes of varying composition have been studied. Structural studies were performed by means of cryo-transmission electron microscopy (c-TEM) and reveal that inclusion of low amounts (∼2 mol %) of Pluronics gives rise to significant morphological changes of the liposome preparations. Pluronics with large poly(oxyethylene) (PEO) blocks, such as F127, F108, and F87, induce the formation of bilayer disks, whereas those with comparably short PEO blocks, P105 and P85, tend to to promote a reduction in the liposome size. Inclusion of cholesterol in the liposomal preparations reduces the incorporation of copolymers in the lipid bilayer and thus reduces, and in some cases even abolishes, the morphological changes observed in the absence of cholesterol. The effect of the copolymers on liposome permeability was also investigated. All investigated copolymers were found to increase the leakage of carboxyfluorescein from preformed liposomes. This was true also in the case of cholesterol-containing liposomes despite the fact that no change in the liposome structure could be observed by means of c-TEM. The magnitude of the induced leakage was found to correlate well with the hydrophobicity, as measured by the cmc, of the respective Pluronic. By raising the temperature or decreasing the solvency of the copolymer in the solution, the effect of the copolymer on liposome leakage was found to increase significantly.