gebhart/patrepeval huggingface dataset:
Hyaluronic acid–collagen network interactions during the dynamic compression and recovery of cartilage (2012)

A compression cell designed to fit inside an NMR spectrometer was used to investigate (i) the in situ dynamic strain response and structural changes of the internal pore network, and (ii) the diffusion and flow of interstitial water, in full thickness cartilage samples as they were mechanically deformed under a constant compressive load (pressure) and then allowed to recover (swell again) when the load was removed. Selective enzymatic digestion of the collagen fibril network and the glycopolysaccharide hyaluronic acid (HA) was performed to mimic some of the structural and compositional changes associated with osteoarthritis. Digestion of collagen gave rise to mechanical ‘dynamic softening’ and—perhaps more importantly—nearly complete loss in the ability to recover through swelling, both effects due to the disruption of the hierarchical structure and fibril interconnectivity in the collagen network which adversely affects its ability to deform reversibly and to properly regulate the pressurization and resulting rate and direction of interstitial fluid flow. In contrast, digestion of HA inside the collagen pore network caused the cartilage to ‘dynamically stiffen’ which is attributed to the decrease in the osmotic (entropic) pressure of the digested HA molecules confined in the cartilage pores that causes the network to contract and thereby become less permeable to flow. These digestion-induced changes in cartilage's properties reveal a complex relationship between the molecular weight and concentration of the HA in the interstitial fluid, and the structure and properties of the collagen fibril pore network, and provide new insights into how changes in either could influence the onset and progression of osteoarthritis.
Identification of a 67‐amino‐acid region of the <i>Plasmodium falciparum</i> variant surface antigen that binds chondroitin sulphate A and elicits antibodies reactive with the surface of placental isolates (2004)

The complications of malaria in pregnancy are caused by the massive sequestration of parasitized erythrocytes (PE) in the placenta. Placental isolates of Plasmodium falciparum are unusual in that they do not bind the primary microvasculature receptor CD36 but instead bind chondroitin sulphate A (CSA). Pregnant mothers develop antibodies that recognize placental variants worldwide, suggesting that a vaccine against malaria in pregnancy is possible. Some members of the Duffy binding-like gamma (DBL-gamma) domain of the large and diverse P. falciparum erythrocyte membrane protein-1 (PfEMP-1) family, when expressed on Chinese hamster ovary (CHO) cells, bind CSA. To characterize better the molecular requirements for DBL-gamma adhesion to CSA, we determined the binding of various DBL-gamma domains. Most DBL-gamma did not bind CSA, and no conserved region was identified that strictly differentiated binders from non-binders. Structure-function analysis of the FCR3-CSA DBL-gamma domain localized the minimal CSA binding region to a 67-residue fragment. This region was partially conserved among some binding sequences. Serum from a rabbit immunized with the minimal domain reacted with CSA-binding parasite lines, but not with non-CSA-adherent PE lines that adhered to CD36 and other receptors. The identification of a minimal binding region from a highly variable cytoadherent family may have application for a vaccine against malaria in pregnancy.
Rf Power Consumption Emulation Optimized With Interval Valued Homotopies (2011)

This paper presents a methodology towards the emulation of the electrical power consumption of the RF device during the cellular phone/handset transmission mode using the LTE technology. The emulation methodology takes the physical environmental variables and the logical interface between the baseband and the RF system as inputs to compute the emulated power dissipation of the RF device. The emulated power, in between the measured points corresponding to the discrete values of the logical interface parameters is computed as a polynomial interpolation using polynomial basis functions. The evaluation of polynomial and spline curve fitting models showed a respective divergence (test error) of 8% and 0.02% from the physically measured power consumption. The precisions of the instruments used for the physical measurements have been modeled as intervals. We have been able to model the power consumption of the RF device operating at 5MHz using homotopy between 2 continuous power consumptions of the RF device operating at the bandwidths 3MHz and 10MHz.
Radiation of dipoles at the interface of anisotropic low permittivity media (2013)

The radiation patterns of a dipole at the interface of a general anisotropic medium and air is calculated using the Lorentz reciprocity method. It is shown that by using a homogenous Epsilon Near Zero (ENZ) material, one can obtain interesting shaped radiation patterns in air which were previously attainable only inside a dielectric of high permittivity. In such cases the radiation in air is much stronger than in the ENZ media. Anisotropic ENZs which can be more readily attained in practice, are shown to also yield similar radiation patterns realized in air.
The Case for Privacy Awareness Requirements (2019)

Privacy awareness is a core determinant of the success or failure of privacy infrastructures: if systems and users are not aware of potential privacy concerns, they cannot effectively discover, use or judge the effectiveness of privacy management capabilities. Yet, privacy awareness is only implicitly described or implemented during the privacy engineering of software systems. In this paper, the author advocates a systematic approach to considering privacy awareness. He characterizes privacy awareness and illustrate its benefits to preserving privacy in a smart mobile environment. The author proposes privacy awareness requirements to anchor the consideration of privacy awareness needs of software systems. Based on these needs, an initial process framework for the identification of privacy awareness issues is proposed. He also argues that a systematic route to privacy awareness necessitates the investigation of an appropriate representation language, analysis mechanisms and understanding the socio-technical factors that impact the manner in which we regulate our privacy.
Report On Design And Preliminary Data Of Halden In-Pile Creep Rig (2015)

A set of in-pile creep tests is ongoing in the Halden reactor on ORNL’s candidate accident tolerant fuel cladding materials. These tests are meant to provide essential material property information that is needed for an informed analysis of these fuel concepts under normal operating conditions. These tests provide detailed information regarding swelling, thermal creep, and irradiation creep rates of these materials. The results to date have been compared with the limited set of information available in literature that is form irradiation tests in other reactors or out-of-pile tests. Most of the results are in good agreement with prior literature, except for irradiation creep rate of SiC. To elucidate the difference between the HFIR and Halden test results continued testing is necessary. The tests describe in this progress report are ongoing and will continue for at least another year.
Diversity and bioprospecting of fungal communities associated with endemic and cold-adapted macroalgae in Antarctica (2013)

We surveyed the distribution and diversity of fungi associated with eight macroalgae from Antarctica and their capability to produce bioactive compounds. The collections yielded 148 fungal isolates, which were identified using molecular methods as belonging to 21 genera and 50 taxa. The most frequent taxa were Geomyces species (sp.), Penicillium sp. and Metschnikowia australis. Seven fungal isolates associated with the endemic Antarctic macroalgae Monostroma hariotii (Chlorophyte) displayed high internal transcribed spacer sequences similarities with the psychrophilic pathogenic fungus Geomyces destructans. Thirty-three fungal singletons (66%) were identified, representing rare components of the fungal communities. The fungal communities displayed high diversity, richness and dominance indices; however, rarefaction curves indicated that not all of the fungal diversity present was recovered. Penicillium sp. UFMGCB 6034 and Penicillium sp. UFMGCB 6120, recovered from the endemic species Palmaria decipiens (Rhodophyte) and M. hariotii, respectively, yielded extracts with high and selective antifungal and/or trypanocidal activities, in which a preliminary spectral analysis using proton nuclear magnetic resonance spectroscopy indicated the presence of highly functionalised aromatic compounds. These results suggest that the endemic and cold-adapted macroalgae of Antarctica shelter a rich, diversity and complex fungal communities consisting of a few dominant indigenous or mesophilic cold-adapted species, and a large number of rare and/or endemic taxa, which may provide an interesting model of algal-fungal interactions under extreme conditions as well as a potential source of bioactive compounds.
Fundamental and experimental studies on the catalytic combustion of methane. Annual report, July 1, 1991-June 30, 1992 (1992)

The overall Objective of the project is to obtain and use fundamental experimental data on surface reactivity to model real catalytic combustors. The objective is being approached by focusing on two experimental areas (1) the effect of surface reactivity on heat and mass transfer and (2) the surface reactivity of natural gas on supported metal catalysts.
Supplementary Table Legend from Direct Targeting of MEK1/2 and RSK2 by Silybin Induces Cell-Cycle Arrest and Inhibits Melanoma Cell Growth (2023)

&lt;p&gt;PDF file - 52K&lt;/p&gt;
Genome-Wide Exploration of miRNA Function in Mammalian Muscle Cell Differentiation (2013)

MiRNAs impact on the control of cell fate by regulating gene expression at the post-transcriptional level. Here, using mammalian muscle differentiation as a model and a phenotypic loss-of-function screen, we explored the function of miRNAs at the genome-wide level. We found that the depletion of a high number of miRNAs (63) impacted on differentiation of human muscle precursors, underscoring the importance of this post-transcriptional mechanism of gene regulation. Interestingly, a comparison with miRNA expression profiles revealed that most of the hit miRNAs did not show any significant variations of expression during differentiation. These constitutively expressed miRNAs might be required for basic and/or essential cell function, or else might be regulated at the post-transcriptional level. MiRNA inhibition yielded a variety of phenotypes, reflecting the widespread miRNA involvement in differentiation. Using a functional screen (the STarS--Suppressor Target Screen--approach, i. e. concomitant knockdown of miRNAs and of candidate target proteins), we discovered miRNA protein targets that are previously uncharacterized controllers of muscle-cell terminal differentiation. Our results provide a strategy for functional annotation of the human miRnome.
Entropically Driven Self‐Assembly of Bolaamphiphilic Perylene Dyes in Water (2016)

The specific hydrophobic effect involved in the self-assembly of a bolaamphiphilic perylene bisimide (PBI) dye bearing oligoethylene glycol (OEG) chains has been identified. In pure water, the self-assembly is entropically driven and enthalpically disfavored, as explored by optical spectroscopy and isothermal titration calorimetry studies. Besides strong π-π interactions between the PBI units that are primarily of enthalpic nature, the major contribution to the self-assembly is the gain of entropy by release of confined water molecules from the hydration shell of the hydrophilic OEG moieties. Both contributions favor self-assembly, but their countervailing thermodynamic parameters are reflected in an uncommon temperature dependence, which can be inverted upon gradual addition of an organic cosolvent that makes the π-π interaction increasingly dominant.
ACTPHAST4R: European Open Access Platform for Photonics Prototyping to Support Innovation-Driven Researchers (2020)

ACTPHAST for Researchers - abbreviated as ACTPHAST4R - is a European Union supported initiative that is specifically designed to providing access for photonics and non-photonics researchers to advanced photonics technology platforms, with the aim to demonstrate their conceptual breakthroughs with industrially-relevant equipment. In this paper, we summarize the premises on which ACTPHAST4R builds and how innovation-driven researchers can benefit from ACTPHAST4R support, more specifically how they can gain open access to the best photonics prototyping platforms in Europe.
Targeting of Lewis‐a glycans accelerates chemotaxis and transepithelial migration by human PMNs (650.9) (2014)

Pathogen‐triggered neutrophil (PMN) recruitment is critical for innate immunity, but aberrant PMN influx into intestinal crypts marks disease severity in inflammatory bowel disease (IBD). Fucosylated terminal glycans, such as Lewis‐x (Lex) and Sialyl Lewis‐x, have previously been implicated in the regulation of important PMN functions, including selectin‐mediated PMN trafficking. While such glycans based on the type 2 sequence (Galβ1‐4GlcNAc‐R) are abundant on PMNs, it was previously thought that PMNs lack type 1 glycans (Galβ1‐3GlcNAc‐R) required for the expression of Lewis‐a (Lea). Here, we demonstrate through immunoblot, flow cytometry, and immunohistochemical analyses of tissues from individuals with IBD, that Lea is in fact present on human PMNs. Further, immunoblotting revealed robust PMN expression of Fucosyltransferase 3/5, glycosyltransferases with α1/4 fucosyltransferase activity, required for the terminal step in Lea synthesis. We further report that treatment of PMN with Lea‐specific Abs increases both chemotaxis across collagen and migration across model intestinal epithelia. Thus, we identify novel expression of Lea by human PMN and demonstrate its relevance to PMN trafficking within the intestine. PMN Lea represents a novel target for regulating intestinal innate immunity and may be a rational target for modulating inflammation in IBD. Grant Funding Source : Supported by Crohn's &amp; Colitis Foundation of America and National Institutes of Health
Ensuring High-Performance of Mission-Critical Java Applications in Multi-tenant Cloud Platforms (2014)

Cloud Computing promises a cost-effective and administration-effective solution to the traditional needs of computing resources. While bringing efficiency to the users thanks to the shared hardware and software, the multi-tenency characteristics also bring unique challenges to the backend cloud platforms. In particular, the JVM mechanisms used by Java applications, coupled with OS-level features, give rise to a set of problems that are not present in other deployment scenarios. In this work, we consider the problem of ensuring high-performance of mission-critical Java applications in multi-tenant cloud environments. Based on our experiences with Linkedin's platforms, we identify and solve a set of problems caused by multi-tenancy. We share the lessons and knowledge we learned during the course.
Association of human antigen class I genes with cold medicine-related Stevens-Johnson syndrome with severe ocular complications in a Korean population (2019)

This multicentre case-control study enrolled 40 Korean patients with CM-SJS/TEN with SOC and 120 age-matched and sex-matched Korean healthy volunteers between January 2012 and May 2014. HLA genotyping was performed using PCR followed by hybridisation with sequence-specific oligonucleotide probes. RESULTS : The carrier frequency and gene frequency of HLA-A*02:06 were 37.5 % and 20.0 %, respectively, in patients, and 16.7 % and 9.6 %, respectively, in controls (p=0.018). The carrier frequency of HLA-C*03:04 was 30 % in patients and 10.8 % in controls, and gene frequency of HLA-C*03:04 was 15 % in patients and 5.4 % in controls (p=0.003). The carrier frequency and gene frequency of HLA-C*03:03 were 2.5 % and 1.3 %, respectively, in patients, and 20 % and 10.4 %, respectively, in controls (p=0.006). CONCLUSIONS : As per our results, we suggest that HLA-A*02:06 and HLA-C*03:04 might be positive markers for CM-SJS/TEN with SOC, and HLA-C*03:03 might be an indicator of protection against CM-SJS/TEN with SOC in the Korean population.
Secondary Surgical Cytoreduction for Recurrent Ovarian Cancer (2020)

(Abstracted from N Engl J Med 2019;381:1929–1939) The National Comprehensive Cancer Network recommends secondary cytoreduction for ovarian cancer patients with recurrent disease who have received no treatment for a period of 6 months following a complete response from prior chemotherapy. Retrospective reviews and meta-analyses have shown the most benefit from this operation in those with platinum-sensitive disease and those with little or no postoperative residual disease.
Large-scale Job Management System Based on Partition and Lease Technologies (2007)

Partitioned workload system(PWS)is one job management system using partition and dynamic resources-lease technology,which enhances the manageability of JMS and improves the utilization of cluster system.With optimized communication system,PWS can support cluster systems with thousands of CPUs or nodes.PWS has been applied in Shuguang 4000A super server and other computation fields requiring high performances,the design and implementation of the PWS is introduced.
CD4<sup>+</sup>CD25<sup>+</sup>regulatory T-cell therapy (2006)

Naturally occurring CD4(+)CD25(+) regulatory T cells (Tregs) expressing forkhead transcript factor box P3 have been established as a key regulator for the control of autoimmunity. A growing body of experiments in animal models has provided compelling evidence that the adoptive transfer of CD4(+)CD25(+) Tregs can cure many autoimmune and allergic diseases, and appear to induce donor-specific transplantation tolerance. Thus, customer-tailored CD4(+)CD25(+) Tregs have emerged as potential reagents for adoptive cell therapy for individualized medicine. This review discusses recent advances towards that goal.
Optical Probe Ion and Carrier Dynamics at the CH<sub>3</sub>NH<sub>3</sub>PbI<sub>3</sub> Interface with Electron and Hole Transport Materials (2016)

Ion migration and accumulation in perovskite and interface have recently attracted considerable research interest because it is closely related to carrier extraction and hence to the performance of perovskite solar cells. Here using specific optical probe techniques and perovskite, the authors investigate the effect of light illumination (soaking) at the CH 3 NH 3 PbI 3 /spiro‐OMeTAD and CH 3 NH 3 PbI 3 /Phenyl‐C61‐butyric‐acid‐methyl ester interfaces, focusing on the dynamics of mobile ions and photoexcited carriers. Time dependent photoluminescence (PL) intensity, electron–hole recombination and optical microscopy images are used to monitor the illumination effects at the interface as a function of light illumination time and intensity. Under continuous illumination, the PL intensity exhibits dynamic quenching in the timescale of seconds to minutes. The authors attribute this PL quenching to the accumulation of mobile ions at the interface during light soaking. Only negative ions cause such PL quenching and the rate at which PL intensity decreases depends on the illumination intensity. The authors found that the accumulated ions also impede the extraction of photogenerated holes from the perovskite layer into spiro‐OMeTAD, which increases electron–hole recombination. This investigation provides novel insight into the ion migration mechanism by light soaking and therefore its impact on the operation of a perovskite solar cell.
Compact light source for ultrabroadband coherent anti-Stoke Raman scattering (CARS) microscopy (2015)

A compact light source module for ultrabroadband coherent anti-Stoke Raman scattering (CARS) microscopy was developed. It mainly consists of a nanosecond microchip laser, a photonic crystal fiber for Stokes light generation, and a single mode polarization maintaining fiber for pump light propagation. It is alignment-free and relatively low-cost compared with previous light sources of CARS microscopy. By using an assembled module, we successfully observed an ultrabroadband CARS spectrum and a CARS image of a murine adipocyte. The module is expected to greatly spread the CARS microscopy to various fields by its extreme easiness to handle.
Lignanes, 12. Preparation de la (R)-(+)-β-(Trimethoxy-3,4,5-benzyl) γ-butyrolactone et Son Utilisation dans la Synthese Totale de Lignanes Naturels (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLignanes, 12. Preparation de la (R)-(+)-β-(Trimethoxy-3,4,5-benzyl) γ-butyrolactone et Son Utilisation dans la Synthese Totale de Lignanes NaturelsKhalid Lalami, Robert Dhal, and Eric BrownCite this: J. Nat. Prod. 1991, 54, 1, 119–126Publication Date (Print):January 1, 1991Publication History Published online1 July 2004Published inissue 1 January 1991https://pubs.acs.org/doi/10.1021/np50073a009https://doi.org/10.1021/np50073a009research-articleACS PublicationsRequest reuse permissionsArticle Views82Altmetric-Citations9LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Effect of Amphoteric Comb-Like Copolymer Dispersant on Dispersibility and Dispersibility Retention of Cement Pastes (2012)

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