gebhart/patrepeval huggingface dataset:
Supplementary Figure 2 and 3 from Local Delivery of &lt;i&gt;Ox40l&lt;/i&gt;, &lt;i&gt;Cd80&lt;/i&gt;, and &lt;i&gt;Cd86&lt;/i&gt; mRNA Kindles Global Anticancer Immunity (2023)

&lt;p&gt;Supplementary Figure S2. OX40L, CD80 and CD86 mRNA-CART treatment induce long lasting protection against re-challenge with the same tumor cell line. Supplementary Figure S3. OX40L, CD80 and CD86 mRNA-CART treatment do not result in long term elevated levels of pro-inflammatory cytokines in serum of treated mice.&lt;/p&gt;
Long-term trends of ultrafine and fine particle number concentrations in New York State: Apportioning between emissions and dispersion (2022)

In the past several decades, a variety of efforts have been made in the United States to improve air quality, and ambient particulate matter (PM) concentrations have been used as a metric to evaluate the efficacy of environmental policies. However, ambient PM concentrations result from a combination of source emission rates and meteorological conditions, which also change over time. Dispersion normalization was recently developed to reduce the influence of atmospheric dispersion and proved an effective approach that enhanced diel/seasonal patterns and thus provides improved source apportionment results for speciated PM mass and particle number concentration (PNC) measurements. In this work, dispersion normalization was incorporated in long-term trend analysis of 11-500 nm PNCs derived from particle number size distributions (PNSDs) measured in Rochester, NY from 2005 to 2019. Before dispersion normalization, a consistent reduction was observed across the measured size range during 2005-2012, while after 2012, the decreasing trends slowed down for accumulation mode PNCs (100-500 nm) and reversed for ultrafine particles (UFPs, 11-100 nm). Through dispersion normalization, we showed that these changes were driven by both emission rates and dispersion. Thus, it is important for future studies to assess the effects of the changing meteorological conditions when evaluating policy effectiveness on controlling PM concentrations. Before and after dispersion normalization, an evident increase in nucleation mode particles was observed during 2015-2019. This increase was possibly enabled by a cleaner atmosphere and will pose new challenges for future source apportionment and accountability studies.
Numerical study of three-dimensional buoyant convection in rectangular enclosures (1995)

The problem of thermal interaction of melted fuel material (corium) within the reactor vessel is of interest for many reasons in studies of accidents with core melt in nuclear power plants with light water reactors. One of them is an estimation of the lifetime of the reactor vessel and the character of the vessel failure for the existing types of reactors, depending on the main parameters of interaction: residual heat generation, thermal and mechanical properties of materials, and cooling conditions. The second reason is a feasibility study of long-term confinement of fuel fragments for promising reactors with relatively low electric power (400 to 600 MW). We focus on the final state of the core, in which most of the corium material is a homogenous melt, located at the bottom of the reactor vessel.
Spinal arteriovenous fistulas in children with hereditary hemorrhagic telangiectasia (2012)

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant angiodysplasia with high penetrance and variable expression. The manifestations of HHT are often age related, and spinal arteriovenous fistula (AVF) may be the initial presentation of HHT in young children. Because spinal AVFs are rarely reported, however, screening is not incorporated into current clinical recommendations for the treatment of patients with HHT. The authors describe 2 cases of children younger than 2 years of age with acute neurological deterioration in the context of a spinal AVF and in whom HHT was subsequently diagnosed. One patient presented with intraventricular and subarachnoid hemorrhage and the other with acute thrombosis of an intramedullary varix. These cases highlight the potential for significant neurological morbidity from a symptomatic AVF in very young children with HHT. Given the lack of data regarding the true incidence and natural history of these lesions, these cases raise the question of whether spinal cord imaging should be incorporated into screening recommendations for patients with HHT.
Automatic production of tactile graphics from scalable vector graphics (2005)

This paper presents a method to convert vector graphics into tactile representations for the blind. Generating tactile pictures from vector graphics is an important effort to bring more accessibility to the WWW as well as other means of communications since vector graphics are an increasing trend in web based graphics. Prior research has investigated methods that extracts object boundaries from images to produce raised-line tactile pictures. The proposed method extends this idea for vector graphics, producing tactile pictures where important outlines are emphasized. Important outlines are determined by using the hierarchical structure of a vector graphic. A Braille printer is used where raised dots are embossed for the outlining boundaries. Important and detail boundaries are embossed with dots of larger and smaller height, respectively, while all other regions contain no raised dots. Results testing a person's ability to discriminate, identify, and comprehend tactile pictures shows the proposed methods' advantage over two other methods.
Two novel human pancreatic lipase related proteins, hPLRP1 and hPLRP2. Differences in colipase dependence and in lipase activity. (1992)

We have isolated cDNAs coding for two novel human pancreatic lipase (hPL)-related human proteins, referred to as hPL-related proteins 1 and 2 (hPLRP1 and hPLRP2) and for hPL. The two novel proteins show an amino acid sequence identity to hPL of 68 and 65% for hPLRP1 and 2, respectively. All three proteins are secreted into the medium after transfection of COS cells with the corresponding cDNAs. The size of the three expressed proteins is similar and ranges between 45 and 50 kDa. The expressed hPLRP2 shows a lipolytic activity that is, however, in contrast to that of hPL only marginally dependent on the presence of colipase, whereas hPLRP1 shows no activity in this assay. A Northern analysis of normal human pancreas mRNA shows that the expression levels of hPLRP1 and hPLRP2 are about 4-fold and 24-fold lower, respectively, than that of hPL. hPLRP2 is, additionally, most closely related to a lipase reported to be expressed in mouse T-cells. A comparison of the sequences of the three proteins with sequences described as pancreatic lipases of other animal species shows three subfamilies of closer kinship. This suggests that the two novel proteins also exist in other species and that some of the sequences reported to be pancreatic lipase might more likely be the orthologues of hPLRP1 or hPLRP2 in those species.
Non-Monotonic Temperature Dependence of Hydroxide Ion Diffusion in Anion Exchange Membranes (2022)

Recent studies suggest that operating anion exchange membrane (AEM) fuel cells at high temperatures has enormous technological potential. However, obtaining a fundamental understanding of the effect of temperature on hydroxide conductivity and membrane stability remains a key hurdle to realizing the full potential of high-temperature AEM fuel cells. In this work, we present a combined theoretical and experimental study to explore the effect of temperature on hydroxide ion and water diffusivities in AEMs. Both fully atomistic ab initio molecular dynamics simulations and 1H pulsed field gradient NMR measurements confirm that the OH– diffusion changes non-monotonically with increasing temperature. Specifically, the DOH– versus T curve exhibits a region in which dDOH–/dT < 0, indicating the presence of a kink in the curve, which we refer to as a “diffusion kink”. The simulations show that the underlying causes of this behavior vary with the hydration level. Furthermore, we were able to rationalize the conditions underlying this counterintuitive behavior and to suggest ways to identify the optimal operating temperature for each model AEM system. We expect that the discovery of this unusual temperature dependence of the diffusivity will play an important role in the design of new, stable, and highly conductive AEM-based devices such as electrolyzers, redox flow batteries, and fuel cells.
Operation Characteristics of 12-Cavity Relativistic Magnetron With Single-Stepped Cavities (2014)

The possibility of using single-stepped cavities to replace the common tapered cavities was studied using particle-in-cell simulations in an A6 magnetron with diffraction output (MDO). The replacing of the tapered cavities by the single-stepped cavities in a 12-cavity MDO increases the interaction space where the charged particles interact with the induced RF waves. The electronic efficiency of the 12-cavity MDO with single-stepped cavities driven by the transparent cathode [2] of GW output power level can be as high as 73% for α = 18.2°, 74% for α = 17.5°, and 72% for α = 12.5° at β = 32°, where α is the angle between the outer wall and z-axis, and β is the angle between the inner wall and z-axis. The depth of single-stepped cavities is changed when α is changed, which results in different frequency range of magnetron operating modes. When a 400-kV voltage pulse of 10-ns duration is applied to a transparent cathode or a solid cathode, the output power can be as high as 1 GW. Without loss of generality, for α = 12.5° at β = 32°, the peak efficiency around 70% of 12-cavity MDO with single-stepped cavities design occurs at the voltage (V ~ 400 ± 50 kV). The results presented in this paper provide references for relativistic magnetron mode selection or mode switching experiments when choosing the input parameters (magnetic field and accelerating voltage) allowing the magnetron to operate in the desired operation mode.
Psychosocial Screening (1987)

In Reply.— Dr Frankenburg has raised a number of interesting points. Initially, he addresses concern about the use of "questionable" scores for individual sectors of the Denver Developmental Screening Test (DDST). Although we understand that the DDST should not be scored by individual sectors, to obtain a total test result each sector must be scored. On page 26 in the DDST manual/workbook currently distributed, a questionable score results with the following circumstances: "1 or more sectors with 1 delay and in that same sector no passes intersect the age line" (underline appears in manual).1
Superconductivity and Microstructural Observation of Er<sub>0.5</sub>Y<sub>0.5</sub>Ba<sub>2</sub>Cu<sub>3</sub>O<sub>7-y</sub> (1988)

The critical current density, J c , of Er 0.5 Y 0.5 Ba 2 Cu 3 O 7- y was investigated in relation to its microstructure. An increase was observed in the J c of a sintered sample prepared from a mixture of YBa 2 Cu 3 O 7- y and ErBa 2 Cu 3 O 7- y with sintering time of up to 10 h at 930°C. The insufficiently sintered sample had a BaCuO 2 network in the grain boundaries possibly caused by partial melting of the 1:2:3 compounds. This phase disappeared with increased sintering time, which relates to an endothermic reaction. It is considered that the increase in J c is due to an increase in the degree of sintering and to the disappearance of the highly resistive phase from the grain boundary.
Mathematical modeling of the manufacturing process of axisymmetric aircraft parts by the local deformation method (2015)

Parts like shafts and their combinations with discs are very significant elements of the modern aviation gas turbine engines and cognate ground energy propulsions. These parts are usually working in the extremely high loading and temperature conditions and therefore are produced from the highly heat-resistant alloys on the base of Ni, Fe and Ti. The production of these parts with the traditional hot metal forming leads the need of using powerful and energy-consuming equipment. One of the most prospective ways of reducing the load-energy consumption, reducing of the technological operations quantities, increasing of the material efficiency in producing of the axisymmetric aircraft parts is isothermal rolling under the superplastic deformation (SPD) condition using the specialized rolling machines. For the design of this type of machines it is necessary to estimate the load stroke parameters of the process, which the machine has to provide. The effective method of the estimation of the required load stroke parameters is computer simulation of the rolling process. In this paper, the technique to create a finite element model of the process of SPD during isothermal rolling with a high degree of plastic deformation localization is presented and exemplified by the production of disc made of heat-resistant VT9 titanium alloy, in respect to the mechanical properties of the ultra fine grain material microstructure. It is also presented the results of the rolling processes load-stroke, received in the commercial FEM code DEFORM 3D, and the load-stroke data received from the experiment.
Single-hydrophone method for reconstructing dynamic behavior of endangered Chinese river dolphin (2003)

Chinese river dolphin (Lipotes vexillifer), usually called 'baiji', is one of the most endangered mammals in the world. The preservation of these mammals directly ensures the health of the ecosystem. However, not much behavioral information on baiji is available so far, that could effectively assist in undertaking their preservation. This research is an attempt to reveal baiji's hitherto unknown underwater dynamic behavior. For this work we have analyzed and extracted motion parameters from clicks of a free-swimming baiji recorded in 1996 at a single hydrophone. The absence of detailed bottom information made it difficult to localize baiji using the multiple reflections and forced us to rely completely on surface reflections only. From measurements of time delay between the direct path and the surface echo, not only large-scale behavior but also fine-scale behavior has been revealed, such as: periods of diving and surfacing, circling behavior underwater and a characteristic nodding motion. These studies have contributed towards a broad understanding of baiji's foraging exercises from the standpoint of formulating an acoustical survey for the search for this endangered marine mammal.
Global Gene Expression Profiling in the Failing Myocardium (2009)

Heart failure (HF) is a syndrome that involves multiple cellular mechanisms leading to a common phenotype of reduced ventricular contraction and cardiac chamber dilation. To clarify the mechanisms, a number of microarray analyses of the failing myocardium have been conducted. Gene expression profiles are usually compared between opposing pairs of samples, such as non-failing vs failing hearts, ischemic vs non-ischemic hearts, male vs female failing hearts or atria vs ventricles of failing hearts. Apart from these conventional methods, a different novel approach identified cardiac myosin light chain kinase (MLCK) as a HF-related gene by the comprehensive search for the genes that had an expression level that strongly correlated with the severity of HF; further investigations proved the important role of cardiac MLCK in HF. Moreover, a robust gene expression signature composed of 27 genes was revealed on analysis of 4 independent microarray data sets from the failing myocardium of dilated cardiomyopathy. The authors newly demonstrate 107 HF-related genes that were listed in 2 or more of 7 microarray data sets previously reported. Among these genes, many were observed to be involved in mitochondrial dysfunction and oxidative phosphorylation and 3 extracellular molecules, including periostin, pleiotrophin, and SERPINA3, which might become novel diagnostic and therapeutic targets for HF. These novel strategies warrant the new identification of specific genes that are linked to the pathophysiology of HF.
Effect of Negative Pions on Cells Plated on Glass and Plastic Surfaces (1978)

Chinese hamster cells (line V79) plated on glass and plastic surfaces were exposed to pions at the peak position in the depth dose curve (peak width, approximately 3 cm) to ascertain whether significant differences in cell killing are obtained at interfaces of materials of different atomic composition such as bone and soft tissue. No significant differences in cell killing were observed.
ChemInform Abstract: Lipoxins and Related Eicosanoids: Biosynthesis, Chemical Synthesis and Biological Properties (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Real-time water allocation policies calculated with bankruptcy games and genetic programing (2017)

Abstract Population growth coupled with increased urban and agricultural water use have exacerbated water shortages worldwide. Conflicts among water users frequently arise over scarce water. The application of conflict resolution methods has the potential to resolve such conflicts. Bankruptcy games is a branch of game theory applicable to problems dealing with conflict resolution. This study addresses water allocation to urban-industrial, agricultural, and environmental water uses downstream of the Zarrineh-roud dam, Iran, which diverts water from the Zarrineh-roud River, an important tributary to Lake Urmia. Lake Urmia has been severely stressed by reduction of its water inputs. Water allocation is posed in this study as a bankruptcy game in which the allocation to stakeholders is optimized with proportional (P), adjusted proportional, constrained equal award (CEA), and constrained equal losses methods. The CEA was chosen as the best allocation method based on performance criteria and the Bankruptcy Allocation Sustainability Index. Monthly, real-time, water allocation rule curves were calculated with genetic programming.
Co‐localization of inducible nitric oxide synthase and phosphorylated Akt in the lesional skins of patients with melasma (2009)

Activation of the inducible nitric oxide synthase (iNOS)/nitric oxide (NO) pathway in keratinocytes has been reported to be associated with the pathogenesis of melanogenesis. Akt activation plays an important role in the activation of the transcription factor nuclear factor (NF)-kappaB and subsequent elevation of iNOS expression. In the present study, we highly detected both iNOS protein and Akt phosphorylation in keratinocytes of the basal layer of the epidermis at the junction with the dermis of melasma skin biopsy specimens, but not in normal skin tissues, from nine patients using immunohistological analysis. iNOS protein and phosphorylated Akt were co-localized in the lesional skins, and their levels were highly correlated R2= 0.69). Furthermore, iNOS mRNA was also detected in an additional three skin biopsy specimens, but not in normal skin, by reverse transcription polymerase chain reaction. Our results describe that iNOS expression is elevated in human melasma lesions, probably via activation of the Akt/NF-kappaB pathway, indicating that NO production plays an important role in the mechanism of hyperpigmentation in human facial melasma.
Real-time airborne particle analyzer (2023)

An aerosol particle analyzer includes a laser ablation chamber, a gas-filled conduit, and a mass spectrometer. The laser ablation chamber can be operated at a low pressure, which can be from 0.1 mTorr to 30 mTorr. The ablated ions are transferred into a gas-filled conduit. The gas-filled conduit reduces the electrical charge and the speed of ablated ions as they collide and mix with buffer gases in the gas-filled conduit. Preferably, the gas filled-conduit includes an electromagnetic multipole structure that collimates the nascent ions into a beam, which is guided into the mass spectrometer. Because the gas-filled conduit allows storage of vast quantities of the ions from the ablated particles, the ions from a single ablated particle can be analyzed multiple times and by a variety of techniques to supply statistically meaningful analysis of composition and isotope ratios.
More than destructive: neutrophil-derived serine proteases in cytokine bioactivity control (2001)

In addition to the mechanisms inducing the expression and secretion of cytokines under distinct pathophysiological conditions, the fate of cytokines after secretion at sites of inflammation is a field of growing interest. Proteolysis has been suggested to be a fundamental mechanism of regulating the activities of various components of the cytokine network. Evidence grows that besides highly specific cytokine converting proteases such as interleukin-1beta-converting enzyme or tumor necrosis factor-converting enzyme, neutrophil-derived serine proteases are intimately involved in the modulation of the activities of cytokines and their receptors. Particularly at sites of inflammation, high amounts of the active serine proteases elastase, cathepsin G, and proteinase 3 are released from infiltrating polymorphonuclear cells in close temporal correlation to elevated levels of inflammatory cytokines, strongly indicating that these proteases are involved in the control of cytokine bioactivity and availability.
Field Strength and Diffusion Encoding Technique Affect the Apparent Diffusion Coefficient Measurements in Diffusion-Weighted Imaging of the Abdomen (2010)

Measured abdominal ADC values depend on the exact selection of b-value used for encoding for liver, pancreas, and spleen. In addition, the measured ADC values depend on the field strength of the scanner for liver.
Highly efficient, stable and reproducible CdSe-sensitized solar cells using copper sulfide as counter electrodes (2015)

An efficiency of 6.28%, high stability and reproducibility for CdSe sensitized solar cells have been obtained using Cu<sub>x</sub>S as counter electrodes.
High-definition and ultra high-definition IR camera technology (2023)

Cyan Systems has continued to mature our small pixel camera performance, including improvements in the packaging, optics, and electronics. The associated camera components demonstrate key resolution and enabling capabilities. We report on recent results from our new digital readout integrated circuit (DROIC) small pixel mid-wave infrared camera with an ultra-high-definition (3840 x 2160) format, in addition to demonstrations with Cyan’s CS-3 full-high-definition (1920 x 1080) camera. We address small pixel spatial sampling and modulation transfer function issues as the pixel size shrinks, and we examine the difference between the performance of present devices and the new generation of small pixel cameras.