gebhart/patrepeval huggingface dataset:
Leishmaniose visceral canina : Novos antígenos para diagnóstico e vacinas (2017)

A Leishmaniose visceral zoonotica, causada por Leishmania infantum, e uma doenca emergente em paises do Mediterrâneo e das Americas. Caes constituem-se no principal hospedeiro e reservatorio urbano, e a eutanasia de caes soropositivos tem sido adotada como medida de controle. Entretanto, essa medida falha devido, em parte, a baixa sensibilidade de testes de diagnostico. Medidas que visem a reducao da transmissao e aplicacao dessas de forma integrada tornam-se fundamentais, como o diagnostico precoce e de alta sensibilidade dos caes infectados, o tratamento eficaz e o emprego de vacinas. Entre os antigenos disponiveis, A2 se apresentou como um candidato com potencialidade, tendo sido gerados, por nosso grupo de pesquisa, varios reagentes a partir desse com aplicacao em vacinas e diagnostico (FERNANDES et al., 2013). Nao obstante, faz-se ainda necessario identificar outros antigenos de L. infantum para aprimorar as vacinas e as alternativas de diagnostico. Certamente, o uso de analises genomicas e proteomicas e promissor para se alcancar tal objetivo. Aplicamos, portanto, essas analises para a identificacao de novos antigenos de L. infantum.
A Unified theory of scheduling, routing, and flow control in wireless networks (2009)

A new approach to joint scheduling, flow control and routing in wireless networks, based on formulation as a convex optimization problem is presented. This approach is novel in that it integrates optimal scheduling and flow control with a modified version of minimum delay routing, resulting in significant performance advantage over alternative approaches. We come up with a distributed algorithm for implementation of the proposed scheme and show, by analysis and simulation, that the algorithm achieves fairness and/or priorities among users in accordance with pre-assigned user parameters. In sharp contrast to alternative algorithms that perform scheduling and packet routing based on per-session queue differential between adjacent nodes, our algorithm uses a complete multi-hop view of network conditions for packet routing and retains the desirable properties of minimum delay routing. As the result, it achieves queue sizes and end-to-end delays that are several times smaller, without compromising the throughput.
Development of precipitated iron Fischer-Tropsch catalysts. Quarterly technical progress report, 1 January 1995--31 March 1995 (1995)

During the reporting period we completed synthesis of about 100 g of catalyst with nominal composition 100 Fe/3 Cu/4 K/16 SiO{sub 2} (S-3416-2), and of another batch (173 g) of the same catalyst (S-3416-3). Also, we synthesized two additional batches of catalyst with nominal composition 100 Fe/5 Cu/6 K/24 SiO{sub 2}, in the amounts of 240 g (S-5624-3) and 200 g (S-5624-4). These amounts are sufficient for all planned tests with these two catalysts for the entire duration of this contract. The synthesized catalysts were characterized by atomic absorption, and BET surface area and pore size distribution measurements.
Self‐Assembly of Decoupled Borazines on Metal Surfaces: The Role of the Peripheral Groups (2014)

Two borazine derivatives have been synthesised to investigate their self-assembly behaviour on Au(111) and Cu(111) surfaces by scanning tunnelling microscopy (STM) and theoretical simulations. Both borazines form extended 2D networks upon adsorption on both substrates at room temperature. Whereas the more compact triphenyl borazine 1 arranges into close-packed ordered molecular islands with an extremely low density of defects on both substrates, the tris(phenyl-4-phenylethynyl) derivative 2 assembles into porous molecular networks due to its longer lateral substituents. For both species, the steric hindrance between the phenyl and mesityl substituents results in an effective decoupling of the central borazine core from the surface. For borazine 1, this is enough to weaken the molecule-substrate interaction, so that the assemblies are only driven by attractive van der Waals intermolecular forces. For the longer and more flexible borazine 2, a stronger molecule-substrate interaction becomes possible through its peripheral substituents on the more reactive copper surface.
From Images to 3D Shape Attributes (2017)

Our goal in this paper is to investigate properties of 3D shape that can be determined from a single image. We define 3D shape attributes-generic properties of the shape that capture curvature, contact and occupied space. Our first objective is to infer these 3D shape attributes from a single image. A second objective is to infer a 3D shape embedding-a low dimensional vector representing the 3D shape. We study how the 3D shape attributes and embedding can be obtained from a single image by training a Convolutional Neural Network (CNN) for this task. We start with synthetic images so that the contribution of various cues and nuisance parameters can be controlled. We then turn to real images and introduce a large scale image dataset of sculptures containing 143K images covering 2197 works from 242 artists. For the CNN trained on the sculpture dataset we show the following: (i) which regions of the imaged sculpture are used by the CNN to infer the 3D shape attributes; (ii) that the shape embedding can be used to match previously unseen sculptures largely independent of viewpoint; and (iii) that the 3D attributes generalize to images of other (non-sculpture) object classes.
Supplementary Figure 1 from Proteomic Characterization of the Angiogenesis Inhibitor SU6668 Reveals Multiple Impacts on Cellular Kinase Signaling (2023)

Supplementary Figure 1 from Proteomic Characterization of the Angiogenesis Inhibitor SU6668 Reveals Multiple Impacts on Cellular Kinase Signaling
Miniature Absolute Optical Pressure Sensor at a Fiber Tip for High Temperature Applications (2012)

Fiber optic pressure sensors have attracted considerable attention because of their small size, high sensitivity and immunity to electromagnetic interference. Here, a miniature absolute pressure sensor at the edge of a fiber is presented. Contradictory to earlier pressure sensors with membranes at the fiber tip (in a co-axial configuration), we present a sensor in a cross-axial configuration. It is optimized for aerodynamic pressure measurements in turbomachinery. The sensor is fabricated by thin film deposition techniques and focused ion beam (FIB) microfabrication and uses multilayer Fabry-Perot (FP) interferometry as sensing principle. The reflected power intensity of the prototype is experimentally verified to be 0.77%/bar.
Genetic and Agronomic Evaluation of <i>wp‐m</i> in Soybean (2000)

Transposable element systems have been proposed to explain instability in floral pigmentation of several plant species, including soybean [ Glycine max (L.) Merr.]. Soybean lines with chimeric (purple and pink sectored) flowers are hypothesized to contain wp‐m , an active transposable element that is able to excise from the wp locus during morphological development. The objectives of this research were (i) to determine the inheritance of the chimeric flower phenotype when crossed to stable pink or purple flowered revertant lines and (ii) to determine the effect of wp on agronomic traits in stable flowered lines derived from wp‐m Chimeric flowers crossed to pink flowered revertant ( wp *) lines produced four F 2 populations with unusual segregation ratios of 52 pink, three purple, and two chimeric flowered plants. Crossing chimeric flowers to revertant purple flowered ( Wp *) lines resulted in F 2 populations that did not have the chimeric flower phenotype evident. In the agronomic evaluations, stable wp * lines were later in maturity and averaged 4 g kg −1 higher in protein content and 3 g kg −1 lower in oil content than Wp * lines. The data suggest wp acts in a pleiotropic manner to influence protein synthesis, as purple flowered revertant lines from a pink flower source had lower protein content than sister lines with wp *. Pink flowered lines derived from a purple flower source had higher levels of protein than sister lines with Wp *. The influence of wp on the anthocyanin pathway, plant morphology, and protein accumulation is a unique phenomenon that has not been reported in other plant species.
Phase Equilibria of the Ternary System Water + Propionic Acid + 2-Butanol (1997)

Abstract Liquid–liquid equilibria for the ternary system water + propionic acid + 2-butanol was measured over a temperature range of 298 to 318 K. The results were used to estimate the interaction parameters between each of the three compounds for the nonrandom, two liquid (NRTL) equilibrium model as a function of temperature. The estimated interaction parameters were successfully used to predict the equilibrium compositions by the NRTL model. Based on this work, the distribution coefficients were also calculated and compared with the experimental values.
Purification and characterization of β-Mannanase from <i>Reinekea</i> sp. KIT-YO10 with transglycosylation activity (2014)

Marine bacterium Reinekea sp. KIT-YO10 was isolated from the seashore of Kanazawa Port in Japan as a seaweed-degrading bacterium. Homology between KIT-YO10 16S rDNA and the 16S rDNA of Reinekea blandensis and Reinekea marinisedimentorum was 96.4 and 95.4%, respectively. Endo-1,4-β-D-mannanase (β-mannanase, EC 3.2.1.78) from Reinekea sp. KIT-YO10 was purified 29.4-fold to a 21% yield using anion exchange chromatography. The purified enzyme had a molecular mass of 44.3 kDa, as estimated by SDS-PAGE. Furthermore, the purified enzyme displayed high specificity for konjac glucomannan, with no secondary agarase and arginase activity detected. Hydrolysis of konjac glucomannan and locust bean gum yielded oligosaccharides, compatible with an endo mode of substrate depolymerization. The purified enzyme possessed transglycosylation activity when mannooligosaccharides (mannotriose or mannotetraose) were used as substrates. Optimal pH and temperature were determined to be 8.0 and 70 °C, respectively. It showed thermostability at temperatures from 20 to 50 °C and alkaline stability up to pH 10.0. The current enzyme was thermostable and thermophile compared to the β-mannanase of other marine bacteria.
Ultrasonic attenuation imaging using spectral cross-correlation and the reference phantom method (2011)

Estimation of ultrasonic attenuation properties of soft tissue provides an additional diagnosis tool that may help distinguish benign from malignant tumors and detect diffuse disease. Previously introduced methods of obtaining attenuation slope estimates using medical ultrasound include spectral difference and spectral shift based methods. Recently a hybrid spectral domain method which combines the ideas of using a reference phantom with known attenuation and backscatter properties to reduce system effects and using spectral cross-correlation for frequency downshift estimation was described. The hybrid method reduces the impact of system dependent parameters including diffraction effects by normalizing the sample power spectrum by the reference power spectrum. Although the hybrid method provides improvements with regard to estimation accuracy and reduced impact of backscatter level changes, it shows resolution limitations and deficiencies in background suppression when used to generate attenuation images. Hence, it is unable to provide localized attenuation information. In this paper we provide a theoretical derivation demonstrating a linear relationship between the frequency downshift of normalized power spectrum with imaging depth, without reintroducing the transmit pulse shape to the normalized power spectrum.
High-dose Hydroxychloroquine for Mild COVID-19: One Center’s Clinical Experience and Investigational Challenges (2020)

Aims: The recently described SARS-CoV-2 has led to a pandemia which has severe consequences for the global community. Hydroxychloroquine has been repurposed for the treatment of COVID-19 but conflicting information on its efficacy and safety has since emerged. Our group designed a trial on the use of high-dose hydroxychloroquine in a high-risk ambulatory population with mild COVID-19 (NCT04351620) and summarizes herein the clinical data of hydroxychloroquine in COVID-19. Methods: Single-arm and single-center study evaluating the tolerability of high-dose hydroxychloroquine, 600 mg twice daily for 5 days, in patients with mild COVID-19 and risk factors for clinical decompensation and hospitalization. Secondary objectives included maintenance of ambulatory status, defervescence, and symptom relief. Results: Over a six-week period, 59 patients met eligibility criteria out of 314 contacted (18.7%). Out of these 59 potentially eligible patients, 44 (74.5%) patients declined to be screened further due to concerns about its risks and unproven efficacy, referencing media accounts and politization of the medication. Out of the 9 patients consented, 2 did not complete the therapy plan, 1 due to headaches, 1 did not follow up. Two of the 7 patients who completed the study continued to have fevers, one was admitted for pneumonia. Study was terminated early due to recruitment difficulties. Conclusions: The trial met pre-defined primary outcome of tolerability, but sample size was too small to allow further interpretation. The political climate and media coverage might have negatively impacted patient recruitment, which has ultimately led to its early interruption.
Characterization of 125I‐IABN, a novel azabicyclononane benzamide selective for D2‐like dopamine receptors (2000)

The properties of an 125I-labeled structural analog of 2,3-dimethoxy-N-[9-(4-fluorobenzyl)-9-azabicyclo[3.3.1]nonan-3β-yl]benzamide (MABN), 125I-IABN, are described. 125I-IABN was developed as a high-affinity radioligand selective for the D2-like (D2, D3, and D4) dopamine receptor subtypes. 125I-IABN binds with picomolar affinity and nonselectively to rat D2 and D3 dopamine receptors expressed in Sf9 and HEK 293 cells. 125I-IABN binds with 7- to 25-fold lower affinity to human D4.4 dopamine receptors expressed in HEK 293 cells. Dissociation constants (Kd) calculated from kinetic experiments were in agreement with equilibrium Kd values obtained from saturation binding studies. Saturation plots of the binding of 125I-IABN with rat caudate membrane preparations were monophasic and exhibited low nonspecific binding. The pharmacologic profile of the binding of 125I-IABN to rat caudate was consistent with a D2-like receptor, suggesting that the ligand binds primarily to D2 dopamine receptors. In addition, IABN was found to bind with low affinity to D1 dopamine receptors, as well as to the σ1 and σ2 receptor subtypes. Quantitative autoradiographic studies using rat brain slices indicate that 125I-IABN selectively labels the striatum and the olfactory tubercle area, which is consistent with the labeling of D2-like receptors. IABN blocks dopamine-dependent inhibition of adenylyl cyclase activity at D2 or D4.4 receptors expressed in HEK cells. Therefore, 125I-IABN appears to be a high-affinity, selective antagonist at D2-like dopamine receptors. Finally, a unique property of the azabicyclononane benzamide 125I-IABN compared to previously studied substituted benzamides is that the binding of this radioligand is not effected by variations in Na+ concentration. Synapse 38:438–449, 2000. © 2000 Wiley-Liss, Inc.
Statistical Signal Processing for Demining: Continuation and Field Evaluation (2008)

Abstract : In this program, we investigated basic questions of interest to NVESD regarding landmine detection phenomenology, and developed algorithms for robust landmine detection for a variety of sensors, with primary focus on NIITEK radar-based sensors. We have developed a highly effective pre-screener algorithm that has been tested on several field sites, blind tests, and several offroad sites. The performance of the algorithm on the blind tests were outstanding, and in conjunction with the radar one to two orders of magnitude improvement in false alarm rates over other deployed systems. This prescreener has been transitioned to NIITEK so that they can code it in their real-time processing.
Implementing Qualitative Reasoning for Structural Design Using Constraint Propagation (1993)

Note: Applied computing Reference IMAC-CONF-1993-003 Record created on 2007-08-14, modified on 2016-08-08
Multicenter Trial to Evaluate Vascular Magnetic Resonance Angiography of the Lower Extremity (1995)

Individually, MRA and CA are approximately equivalent in diagnostic accuracy. The addition of MRA to treatment plans based only on CA and other diagnostic information clearly improves the plans. Completed in 15 months (as planned), our study demonstrates the feasibility of conducting rigorous technology assessment rapidly enough to be timely even in fields in which diagnostic and treatment techniques are rapidly changing.
Universal communication over modulo-additive individual noise sequence channels (2011)

Which communication rates can be attained over a channel whose output is an unknown (possibly stochastic) function of the input that may vary arbitrarily in time with no a-priori model? Following the spirit of the finite-state compressibility of a sequence defined by Lempel and Ziv, we define a “capacity” for such a channel as the highest rate achievable by a designer knowing the particular relation that indeed exists between the input and output for all times, yet is constrained to use a fixed finite-length block communication scheme (i.e., use the same scheme over each block). In the case of the binary modulo additive channel, where the output sequence is obtained by modulo addition of an unknown individual sequence to the input sequence, this capacity is upper bounded by 1 - ρ where ρ is the finite state compressibility of the noise sequence. We present a communication scheme with feedback that attains this rate universally without prior knowledge of the noise sequence.
Bio-poly(butylene succinate) and Its Composites with Grape Pomace: Mechanical Performance and Thermal Properties (2018)

Biocomposites from bio-based poly(butylene succinate) (BioPBS) and grape pomace (GP) were made by melt extrusion-injection molding. Grape pomace is a low value byproduct from the wine industry that can be utilized as a filler to increase its value and to decrease the amount of polymer required in a composite blend. Experiments were performed with up to 50% grape pomace by weight. Composites were also compatibilized with in situ manufactured maleic anhydride-grafted BioPBS (MA-<i>g</i>-BioPBS). Flexural and impact strength were improved with the addition of GP up to the addition of 50 wt % GP, suggesting that at this loading the formulation reached threshold performance. The blend of (57:40:3) BioPBS/GP/MA-<i>g</i>-BioPBS showed the best overall performance in terms of a balance of both mechanical properties and thermal properties. The increase in impact resistance confirmed that the GP acted as a reinforcing phase. The addition of 3 wt % MA-<i>g</i>-BioPBS in samples containing 40 wt % of grape pomace resulted in improvements of 28.4 and 59% in flexural and impact strengths, respectively, compared to neat BioPBS. Heat distortion temperature increased with the addition of grape pomace by 14.3% in a blend combination of 57% BioPBS, 40% grape pomace, and 3% MA-<i>g</i>-BioPBS compared to neat BioPBS. Scanning electron microscopy results show improved interfacial adhesion with the addition of MA-<i>g</i>-BioPBS and thermogravimetric analysis results prove that the GP is thermally stable under the processing conditions. This study shows that GP can be successfully incorporated into a BioPBS matrix to create biocomposites with improved thermal and mechanical properties.
Hysteresis during Cycling of Lithiated Silicon Electrode (2008)

Abstract not Available.
Supplementary Data from Preclinical Evaluation of Telomerase-Specific Oncolytic Virotherapy for Human Bone and Soft Tissue Sarcomas (2023)

&lt;p&gt;Supplementary Figures S1-S5; Supplementary Table S1.&lt;/p&gt;
Reaction of nitrous oxide with methane to produce synthesis gas (CO + H2); a thermodynamic and catalytic analysis (2014)

A thermodynamic and kinetic (experimental) study of N2O with CH4 to synthesis gas (H2+CO) formation was investigated under various reaction conditions. The experimental study was carried out over Co-ZSM-5 as catalyst in a fixed bed reactor. The effect of temperature (270 °C -570 °C) and molar feed ratio (N2O/CH4 = 1, 3, and 5) was examined in order to determine conditions for maximizing H2 yield. The results show that for the molar feed ratios (N2O/CH4) of 1 and 3, N2O is the limiting reactant. The thermodynamic and kinetic analyses of the reaction having a limiting N2O reactant in reactant feed (N2O/CH4) shows that H2 yield steadily increased with increase in temperature and the level of CH4 conversion. Furthermore, the maximum attainable (from thermodynamic calculations) H2 yield at 550°C is about 20%. While thermodynamic predictions of H2 yield drops to zero in presence of excess of N2O in reactant feed (N2O/CH4 = 5). Over Co-ZSM-5 catalyst and with a molar reactant feed ratio (N2O/CH4) of 5, the H2 yield first increases to 10 % with rise in temperature and then drops to zero at relatively higher range of temperatures (above 425°C). The synthesis gas production from partial oxidation of CH4 with N2O may not be an alternative route to existing industrial practice; however, the fractional substitution of O2 with N2O in the partial oxidation of CH4 could lead to emission reductions. This will also give a new route for H2 generation.
Free radical entry in emulsion polymerizations (1992)

Abstract Measurements of the rate coefficients characterising the entry of free radicals into seed particles in styrene emulsion polymerizations has allowed the rate determining step for entry to be identified. This was found to be the rate of production of oligomeric species in the aqueous phase by monomer addition to the primary free radicals. Once formed the subsequent diffusion of these species to the latex particles (and their incorporation within these particles) is relatively fast, contrary to the assumptions of the previous diffusion controlled theories. The experimental results imply that the entering free radicals contain only two or three monomer units. Thermodynamic considerations show that such species should be both water soluble and surface active. Similar conclusions have been reached for other sparingly water soluble monomers, such as butyl acrylate and butyl methacrylate.
The Synthetic Versatility of Alkoxycarbonyl‐ and Hydroxymethyl‐piperazine‐2,5‐diones. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Study on Token Pruning for ColBERT (2021)

The ColBERT model has recently been proposed as an effective BERT based ranker. By adopting a late interaction mechanism, a major advantage of ColBERT is that document representations can be precomputed in advance. However, the big downside of the model is the index size, which scales linearly with the number of tokens in the collection. In this paper, we study various designs for ColBERT models in order to attack this problem. While compression techniques have been explored to reduce the index size, in this paper we study token pruning techniques for ColBERT. We compare simple heuristics, as well as a single layer of attention mechanism to select the tokens to keep at indexing time. Our experiments show that ColBERT indexes can be pruned up to 30\% on the MS MARCO passage collection without a significant drop in performance. Finally, we experiment on MS MARCO documents, which reveal several challenges for such mechanism.