gebhart/patrepeval huggingface dataset:
A phase II randomized, double-blind trial of a polyvalent vaccine-KLH conjugate (NSC 748933 IND# 14384) + OPT-821 versus OPT-821 in patients with epithelial ovarian (EOC), fallopian tube, or peritoneal cancer who are in second or third complete remission. (2016)

5517 Background: Phase I data have demonstrated induction of antibody responses to a polyvalent vaccine conjugate (Globo-H, GM2, MUC1-TN, TF) with adjuvant OPT-821. We sought to determine if this combination decreases the hazard of progression versus OPT-821 alone in patients with EOC in second or third clinical complete remission (cCR) following chemotherapy. Secondary objectives were overall survival (OS), safety and immunogenicity. Methods: Patients were randomized (1:1) to receive OPT-821 + vaccine conjugate subcutaneously at weeks 1, 2, 3, 7, 11 and then every 12 weeks (total 11) Dose delay or reduction was not permitted. Patients were removed for pre-defined DLT. Randomized patients were evaluated for efficacy. Results: Between 2010 and 2013 171 patients were randomized; 170 treated. Most received 2 prior regimens (68%), had serous carcinoma (85%), stage 3 disease at diagnosis (77%), and no bevacizumab (67%). 54% received > 6 cycles treatment [median 6 in each arm (p = 0.33)]. 77% of patients discontinued due to progression, 4% due to toxicity, and 1 due to MDS. Maximum toxicity was grade 5 (n = 1, unrelated), grade 4 MDS and depression (n=2, unlikely), grade 3 GI disorders + others (n = 20, 4 related). Most common lesser adverse events were injection site reactions (84%) and fever (19%). (+) immunogenicity is defined as 1:40 or two fold increase. Estimated hazard ratio for PFS of vaccine conjugate + OPT-821 to OPT-821 arm was 0.98 (95% CI: 0.71-1.36). At followup of 34 months, median OS for OPT-821 is 47 months and not reached for vaccine conjugate + OPT-821. Conclusions: Vaccination with this polyvalent construct was modestly immunogenic and does not prolong PFS when compared to OPT-821 alone. The secondary OS endpoint requires additional followup. The second and third remission cohort is a feasible and well defined population to explore innovative consolidation or maintenance approaches. Clinical trial information: NCT00857545.Predefined definition (+) for immunogenicity (patients with pre and post titers n = 148). GLOBO-H GM2 MUC1-TN MUC 1 TF IGG IGM IGG IGM IGG IGM IGG IGM IGG IGM 7% 21% 8% 26% 32% 40% 45% 49% 13% 22%
Uniformly Distributed Near-Field Probing Array for Enhancing the Performance of 5G Millimeter-Wave Beamforming Transmitters (2021)

This letter proposes a uniformly distributed near-field (NF) probing array (NFPA) capable of generating feedback signals suitable for monitoring and improving the performance of a 5G millimeter-wave (mm-wave) beamforming transmitter. The proposed NFPA configuration is carefully designed to ensure comparable coupling ratios between the individual RF chain outputs and the closest NF probes, across a wide frequency range. This maximizes the quality of the feedback signal available to perform array calibration and digital predistortion (DPD) when using realistic 5G modulated signals. A 16-element 27-30-GHz beamforming transmitter is designed and serves as the proof-of-concept prototype. Using a four-element NFPA, the 16 RF chains are calibrated using a 400-MHz modulated signal - achieving less than 0.27 dB and 2.8° root-mean-square (RMS) magnitude and phase calibration errors, respectively. Furthermore, a DPD engine trained using the NFPA-based feedback signal improves the over-the-air transmitted signal's adjacent channel power ratio (ACPR) and error vector magnitude (EVM) from 30 dB and 8.8% to 39 dB and 2.5%, respectively. The DPD also allowed for an increase of the effective isotropic radiated power (EIRP) from 27.5 to 33 dBm while staying below the maximum EVM of 3.5%.
BEM-FEBI Formulation Through ‘PECfication’ (2019)

A multi-region formulation between Finite Element- Boundary Integral (FE-BI) regions and perfectly electric conducting (PEC) boundary element method (BEM) regions is presented. The method proceeds by first transforming the problem into a PEC equivalent one using a custom direct matrix solver within FE-BI regions, and then solving for the electric currents residing on FE-BI and BEM regions iteratively. The full field solutions within those `PECfied' FE-BI regions can then be recovered using those electric currents and the matrix factors from the previous steps. Numerical results for two-dimensional radiation problems are presented.
Phase Sensitive Amplification with SIS (Superconductor-Insulator-Superconductor) Quasiparticle Mixers. (1988)

Abstract : We have obtained the SIS junctions and RF choke structures which we will use in our experiments. These were fabricated for this project by Dr. Michael Cromar at the National Bureau of Standards Cryoelectronics Laboratory in Boulder Colorado. We have measured the DC characteristics of these junctions and have found that they have low leakage currents and RC products that are very close to our design goal. We have made preliminary calculations of the SIS mixer conversion efficiency for the real DC characteristics of our junctions and find that the results show the required phase sensitive response.
Individual patient prediction of seizure lateralization in temporal lobe epilepsy: a comparison between neuropsychological memory measures and the Intracarotid Amobarbital Procedure. (1997)

Neuropsychological assessment has been extensively used in the presurgical evaluation of temporal lobe epilepsy (TLE) patients to assist in determining lateralization of seizure onset. Very few studies have examined the accuracy with which commonly used neuropsychological instruments provide this information in the individual patient. In 81 patients (49 right-, 32 left-TLE) without space-occupying lesions in whom correct seizure lateralization was inferred on the basis of postsurgical seizure-free status, we compared the frequency with which discrepancies between the Wechsler Memory Scale-Revised (WMS-R; Wechsler, 1987) Verbal and Visual Memory Indices, Warrington Recognition Memory Test (WRMT; Warrington, 1984) Words and Faces scaled scores, and Intracarotid Amobarbital Procedure (IAP) hemispheric memory scores correctly predicted seizure lateralization in the individual patient. Using both clinical analysis and discriminant function analyses (DFA), the IAP was found to be a clearly superior predictor of seizure laterality to the neuropsychological measures, whether used individually or in combination with one another. Using clinical analysis the WRMT was found to be a superior predictor to the WMS-R, which frequently gave false lateralizing information. Using all 3 measures in combination with one another, 87.1% of patients were correctly lateralized using DFA. Correctly lateralized patients were older and had longer durations of seizure disorder.
Flying Fast and Low Among Obstacles: Methodology and Experiments (2008)

Safe autonomous flight is essential for widespread acceptance of aircraft that must fly close to the ground. We have developed a method of collision avoidance that can be used in three dimensions in much the same way as autonomous ground vehicles that navigate over unexplored terrain. Safe navigation is accomplished by a combination of online environmental sensing, path planning and collision avoidance. Here we outline our methodology and report results with an autonomous helicopter that operates at low elevations in uncharted environments, some of which are densely populated with obstacles such as buildings, trees and wires. We have recently completed over 700 successful runs in which the helicopter traveled between coarsely specified waypoints separated by hundreds of meters, at speeds of up to 10 m s —1 at elevations of 5—11 m above ground level. The helicopter safely avoids large objects such as buildings and trees but also wires as thin as 6 mm. We believe this represents the first time an air vehicle has traveled this fast so close to obstacles. The collision avoidance method learns to avoid obstacles by observing the performance of a human operator.
Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines (2016)

We have generated and characterized GBM suspension lines derived from patients with GBMs and GBM variants. These oncosphere cell lines will expand the resources available for preclinical study.
Synthesis and Characterization of Fully Deuterated Upilex Type Polyimides (2006)

Polyimide films are materials of choice as membrane shutters of the hohlraum that contains a plastic microshell in which nuclear products are located to carry out Inertial Confinement Fusion experiments. In addition to high mechanical properties, polymer membranes must exhibit a high transparency in the infrared (IR) wavelengths range between 2.86 and 4 μm (3500 and 2500 cm-1) to allow the IR assisted deuterium-tritium ice layer redistribution. Upilex™ type polyimides exhibit the desired mechanical properties but are not transparent in this wavelengths range due to the aromatic C-H stretching bands. In order to provide the required optical properties, the hydrogen atoms must be substituted by deuterium atoms.In the present contribution, we wish to report the first synthesis of a fully deuterated Upilex™ type polyimide. Optimized ways of synthesis and purification for the two deuterated monomers 3,3′,4,4′-biphenyltetracarboxylic dianhydride (BPDA-d6) and p-phenylene diamine (PDA-d4) have been developed. These monomers have been used to prepare deuterated poly(amic-acid) solutions in NMP. Thermal treatment of films obtained from these solutions gives rise to deuterated Upilex type polyimide films. These films show a high transparency in the 2.86-4 μm region. The synthesis and the characterization of this new deuterated polymer will be discussed.
Nonlinear optical properties of LiNbO<sub>3</sub>/Al<sub>2</sub>O<sub>3</sub> films epitaxially grown by pulsed laser deposition (1998)

Abstract Numerous epitaxial LiNbO3 films, i.e., LiNbO3(0001)/Al2O3(0001), LiNbO3(0001)/Al2O3(1120), and LiNbO3(1120)/Al2O3(1120) films, were grown by pulsed laser deposition. Low deposition temperatures below 450°C were used in order to reduce a Li deficient phase, LiNb3O8. Structural properties of the films, including twin formation, were investigated by X-ray θ-2θ scan and pole figure techniques. Nonlinear optical properties of these films were investigated using the Marker fringe and the Senarmont methods. The nonlinear optical coefficients related to the SHG, i.e., d 31 and d 33, were measured and their values were found to be very close to the LiNbO3 single crystal values. It was also found that the SHG φ-scan can provide information on twin formations and in-plane orientation of the film. Electro-optic (EO) properties of the films were also studied. Films with different orientations display large differences in their EO properties: the epitaxial LiNbO3(0001) films show little EO effects, but the LiNbO3(1120) film shows a large quadratic EO behavior with an effective coefficient of 2.38×10×15 m2/V2.
Few-View Projection Reconstruction With an Iterative Reconstruction-Reprojection Algorithm and TV Constraint (2009)

In applications of tomographic imaging, insufficient data problems can take various forms, such as few-view projection imaging which enables rapid scanning with lower X-ray dose. In this work, an iterative reconstruction-reprojection (IRR) algorithm with total variation (TV) constraint is developed for few-view projections. The IRR algorithm is used to estimate the missing projection data by iterative extrapolation between projection and image space. TV minimization is a popular image restoration method with edge preserving. In recent studies, it has been successfully used for reconstructing images from sparse samplings, such as few-view projections. Our method is derived from this work. The combination of IRR and TV achieves both estimation in projection space and regularization in image space, which accelerates the convergence of the iterations. To improve the quality of the image reconstructed from few-view fan-beam projections, a short-scan type IRR is also approached to reduce the redundancy of projection data. An improved weighting function is proposed for few-view short-scan projection reconstruction by the filtered backprojection (FBP) algorithm. Numerical simulations show that the IRR-TV algorithm is effective for the few-view problem of reconstructing sparse-gradient images.
A framework for automated anomaly detection in high frequency water-quality data from in situ sensors (2018)

River water-quality monitoring is increasingly conducted using automated in situ sensors, enabling timelier identification of unexpected values. However, anomalies caused by technical issues confound these data, while the volume and velocity of data prevent manual detection. We present a framework for automated anomaly detection in high-frequency water-quality data from in situ sensors, using turbidity, conductivity and river level data. After identifying end-user needs and defining anomalies, we ranked their importance and selected suitable detection methods. High priority anomalies included sudden isolated spikes and level shifts, most of which were classified correctly by regression-based methods such as autoregressive integrated moving average models. However, using other water-quality variables as covariates reduced performance due to complex relationships among variables. Classification of drift and periods of anomalously low or high variability improved when we applied replaced anomalous measurements with forecasts, but this inflated false positive rates. Feature-based methods also performed well on high priority anomalies, but were also less proficient at detecting lower priority anomalies, resulting in high false negative rates. Unlike regression-based methods, all feature-based methods produced low false positive rates, but did not and require training or optimization. Rule-based methods successfully detected impossible values and missing observations. Thus, we recommend using a combination of methods to improve anomaly detection performance, whilst minimizing false detection rates. Furthermore, our framework emphasizes the importance of communication between end-users and analysts for optimal outcomes with respect to both detection performance and end-user needs. Our framework is applicable to other types of high frequency time-series data and anomaly detection applications.
Tailoring the Asymmetric Structure of NH<sub>2</sub>‐UiO‐66 Metal‐Organic Frameworks for Light‐promoted Selective and Efficient Gold Extraction and Separation (2023)

Designing adsorption materials with high adsorption capacities and selectivities is highly desirable for precious metal recovery. Desorption performance is also particularly crucial for subsequent precious metal recovery and adsorbent regeneration. Herein, a metal-organic framework (MOF) material (NH<sub>2</sub> -UiO-66) with an asymmetric electronic structure of the central zirconium oxygen cluster has an exceptional gold extraction capacity of 2.04 g g<sup>-1</sup> under light irradiation. The selectivity of NH<sub>2</sub> -UiO-66 for gold ions is up to 98.8 % in the presence of interfering ions. Interestingly, the gold ions adsorbed on the surface of NH<sub>2</sub> -UiO-66 spontaneously reduce in situ, undergo nucleation and growth and finally achieve the phase separation of high-purity gold particles from NH<sub>2</sub> -UiO-66. The desorption and separation efficiency of gold particles from the adsorbent surface reaches 89 %. Theoretical calculations indicate that -NH<sub>2</sub> functions as a dual donor of electrons and protons, and the asymmetric structure of NH<sub>2</sub> -UiO-66 leads to energetically advantageous multinuclear gold capture and desorption. This adsorption material can greatly facilitate the recovery of gold from wastewater and can easily realize the recycling of the adsorbent.
Luminescence Studies of Residual Damage in Low-Dose Arsenic Implanted Silicon after High-Temperature Annealing (2011)

In order to prevent the degradation of device performance, it is necessary to detect and reduce residual damage remaining after ion implantation and annealing. In this study, we focused on the high‐temperature annealing process after low‐dose arsenic (As) implantation in silicon (Si) and evaluated the correlation of annealing conditions and damage by cathodoluminescence (CL) compared to Secondary Ion Mass Spectrometry (SIMS) and Junction Photo‐Voltage (JPV) results. Increasing the annealing temperature with the high‐heat‐up rate, As profile and the sheet resistance didn’t change. However, the intensity of the band‐to‐band transition increased with temperature. This implies the some kind of residual damage remains after low‐temperature annealing and it is removed with increasing annealing temperature. On the other hand, with increasing the annealing time at 1200 °C, more As was piled‐up at the SiO2/Si interface and the luminescence intensity decreased. We guess this piled‐up As is inactive and it may create some kind of damage combined with the defects around the interface, and these damage types cause the suppression of the luminescence intensity. We concluded that the luminescence intensity reflects the various kinds of damage and optical characterization methods have a potential to evaluate defect evolution in annealing process.
MavenRank: Identifying Influential Members of the US Senate Using Lexical Centrality (2007)

We introduce a technique for identifying the most salient participants in a discussion. Our method, MavenRank is based on lexical centrality: a random walk is performed on a graph in which each node is a participant in the discussion and an edge links two participants who use similar rhetoric. As a test, we used MavenRank to identify the most influential members of the US Senate using data from the US Congressional Record and used committee ranking to evaluate the output. Our results show that MavenRank scores are largely driven by committee status in most topics, but can capture speaker centrality in topics where speeches are used to indicate ideological position instead of influence legislation. 1
Supplementary Table S1 from Induction of PD-L1 Expression by the EML4–ALK Oncoprotein and Downstream Signaling Pathways in Non–Small Cell Lung Cancer (2023)

&lt;p&gt;Supplementary Table S1. Patient characteristics&lt;/p&gt;
Lower cardiorenal risk with <scp>sodium‐glucose</scp> cotransporter‐2 inhibitors versus dipeptidyl peptidase‐4 inhibitors in patients with type 2 diabetes without cardiovascular and renal diseases: A large multinational observational study (2020)

In this multinational observational study, SGLT2i was associated with a lower risk of HF and CKD versus DPP4i in patients with type 2 diabetes otherwise free from both cardiovascular and renal disease.
Loss of the receptor tyrosine kinase Axl leads to enhanced inflammation in the CNS and delayed removal of myelin debris during Experimental Autoimmune Encephalomyelitis (2011)

These data show that Axl alleviates EAE disease progression and suggests that in EAE Axl functions in the recruitment of microglia/macrophages and in the clearance of debris following demyelination. In addition, these data provide further support that administration of the Axl ligand Gas6 could be therapeutic for immune-mediated demyelinating diseases.
Clinical and demographic characteristics related to onset site and spread of cervical dystonia (2016)

Subgroups had modest but significant differences in the clinical characteristics that may represent different clinical entities or pathophysiologic subtypes. These findings are critical for design and implementation of studies to describe, treat, or modify disease progression in idiopathic isolated cervical dystonia. © 2016 International Parkinson and Movement Disorder Society.
Scan-Specific Accelerated Mri Reconstruction Using Recurrent Neural Networks In A Regularized Self-Consistent Framework (2020)

Long scan duration remains a challenge for high-resolution MRI. Several accelerated imaging strategies have been proposed based on deep learning (DL) that require databases of fully-sampled images for training. However, scan-specific training is desired where individual variability is important, e.g. in free-breathing cardiac MRI, or where such datasets are not available due to scan time constraints for acquiring fully-sampled data. Building on our earlier method called Self-consistent Robust Artificial-neural-networks for k-space Interpolation (sRAKI), we propose a scan-specific DL reconstruction method based on recurrent neural networks that combines training and reconstruction phases of sRAKI. We use self-consistency among coils in k-space and regularization in arbitrary domains, as well as consistency with acquired data, in each iteration of the recurrent network. Results on knee MRI show that this method improves upon parallel imaging and compressed sensing methods.
Modeling and Stress Analysis of a Pre-Shaped Curved Beam: Influence of High Modes of Buckling (2015)

In this paper, we investigate the effect of high modes of buckling on the mechanical behavior of a pre-shaped curved beam. In a first stage, the presented modeling develops further the snapping forces solution and bistability conditions in order to include high modes of buckling. In a second stage, we develop the analytical solution of the stresses inside the beam during deflection between the two sides of buckling. The buckling with or without mechanical conditions on antisymmetric modes, the force characteristics, bistability conditions and stresses are described in this paper based on mathematical approach in order to provide a clear physical understanding of the curved beam behavior and its design parameters. The accurate knowledge of the design parameters is important in order to achieve the best integration of the curved beam in a complete microstructure. The analytical results are compared with and without considering high modes of buckling and have shown to be in excellent agreement with FEM simulations. The results show the importance of the high modes in calculating stresses and snapping forces.
Pressure and flow properties of dual-lumen cannulae for extracorporeal membrane oxygenation (2020)

Non-standardized testing of pressure-flow properties of extracorporeal membrane oxygenation dual-lumen cannulae prevents an adequate prediction of pressure-flow results when these cannulae are used in patients. Properties of dual-lumen cannulae may vary between sizes within same cannula family, in particular concerning the drainage flow.
ChemInform Abstract: Isoprenyl Phosphinylformates: New Inhibitors of Squalene Synthetase. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Low Complexity Soft Decision Decoding Algorithms for Reed-Solomon Codes (2001)

We propose a method to represent non-binary error patterns for Reed-Solomon codes using a trellis. All error patterns are sorted according to their Euclidean distances from the received vector. The decoder searches through the trellis until it finds a codeword. This results in a soft-decision maximum likelihood algorithm with lower complexity compared to other known MLD methods. The proposed MLD algorithm is subsequently modified to further simplify complexity, reflecting in a slight reduction in the error performance. key words: Reed-Solomon code, soft decision decoding