gebhart/patrepeval huggingface dataset:
Structural consequences of heme isomerism in monomeric hemoglobins from Glycera dibranchiata (1987)

Two-dimensional 1H-NMR methods have been used to assign heme and amino acid proton resonances in both isomeric states of the carbon monoxide complexes of two Glycera dibranchiata monomeric hemoglobins, HbA and HbB. For each hemoglobin, there are small differences in heme pocket structure in the two isomeric forms. The largest structural perturbations associated with heme isomerism involve residues close to pyrrole rings I and II. The positions relative to the heme of phenylalanine CD1 and the proximal histidine ligand are almost unaffected by heme isomerism. These residues probably play a key role in determining the location of the heme within the heme pocket.
Study and design of an optode for pH measurement (2013)

The GraftFast<sup>®</sup> process is a simple ant quick method to covalently graft a chemical on a substrate, provided that the chemical has an aromatic primary amine. Thus, this method is studied for an application in pH measurement via an optode. The aim of this PhD work, which started in October 2012, is to covalently graft a dye sensible to pH variations on an optical fiber, so as to be able to solve the stability issues encountered with other techniques used to assemble the dye and the optical fiber – like physical entrapment or electrostatic interactions. The work presented here explains the concept of an optode and the GraftFast<sup>®</sup> process. The first results obtained show the two dyes that will be studied, and that one ot those potential dyes, the neutral red, can be quite efficiently grafted on a gold substrate.
Colloids created by light: Laser-generated nanoparticles for applications in biology and medicine (2017)

Nanomaterials play a major role in today's research and have become almost indispensable in the field of biology and medicine. However, nanomaterials used in biomedicine must meet specific criteria, among which purity has the highest priority, as it ensures maximum biocompatibility. This brief review article is intended to introduce laser ablation in liquids as a facile and rapid method for the preparation of high-purity colloidal nanoparticles. In this context, a brief introduction into the physics of the laser ablation process as well as into the unique properties of the generated nanoparticles is given, while the main focus of this article lies on the applicability of laser-fabricated nanomaterials in biology and medicine, which is illustrated with recent examples.
Pronoun resolution in Japanese sentences using surface expressions and examples (1999)

In this paper, we present a method of estimating referents of demonstrative pronouns, personal pronouns, and zero pronouns in Japanese sentences using examples, surface expressions, topics and foci. Unlike conventional work which was semantic markers for semantic constraints, we used examples for semantic constraints and showed in our experiments that examples are as useful as semantic markers. We also propose many new methods for estimating referents of pronouns. For example, we use the form "X of Y" for estimating referents of demonstrative adjectives. In addition to our new methods, we used many conventional methods. As a result, experiments using these methods obtained a precision rate of 87% in estimating referents of demonstrative pronouns, personal pronouns, and zero pronouns for training sentences, and obtained a precision rate of 78% for test sentences.
Cell-Cycle-Specific and Serum-Dependent Expression of Gamma-Actin mRNA in Swiss Mouse 3T3 Cells (1988)

We isolated cDNA clones that represent genes whose expression is enhanced when resting Swiss mouse 3T3 cells are stimulated to proliferate with serum. Two clones (designated pME1 and pMR6) were analyzed further. A partial sequence analysis of the pME1 insert DNA indicated that it contained a 104-base-pair stretch with extensive homology to the 3' untranslated region of gamma actin. Similar analysis of the insert DNA from the pMR6 clone indicated that it did not correspond to any previously reported gene sequence. We used the pME1 clone as a probe to determine the level of gamma actin-specific transcript in 3T3 cells under a variety of conditions. The level of gamma actin-specific mRNA began to increase in resting cells upon serum stimulation and reached a peak at 6 h. Thereafter its level declined, and by 24 h it was hardly detectable. In contrast, pMR6-specific transcript was detectable in resting cells but remained elevated even at 24 h poststimulation. The level of gamma-actin mRNA was elevated in resting cells by 12-O-tetradecanoylphorbol-13-acetate, calcium ionophore A23187, and bombesin and to a lesser extent by cholera toxin, fibroblast-derived growth factor, and dibutyryl cyclic AMP. However, insulin, vasopressin, or epidermal growth factor failed to enhance gamma-actin mRNA levels in resting cells. Inhibitors of transcription diminished the induction of gamma-actin mRNA. Gamma-actin gene was superinduced in serum-stimulated cells by cycloheximide, an inhibitor of translation. Analysis of proteins from serum-stimulated cells by two-dimensional gel electrophoresis indicated that enhanced transcription of gamma-actin mRNA resulted in a concomitant increase in the corresponding actin protein. The possible role of gamma actin, a component of the cytoskeleton, in the regulation of cell growth is discussed.
Simulation of Triangular-Cell-Shaped, Fibrous Wall-Flow Filters (2003)

&lt;div class="htmlview paragraph"&gt;In the present work we apply a computational simulation framework developed for square-cell shaped honeycomb Diesel Particulate Filters to study the filtration, pressure drop and soot oxidation characteristics of recently developed triangular-cell-shaped, high porosity wall-flow filters. Emphasis is placed on the evaluation of the applicability and adaptation of the previously developed models to the case of triangular channels. To this end Computational Fluid Dynamics, asymptotic analysis, multichannel and “unit-cell” calculations are employed to analyze filter behavior and the results are shown to compare very well to experiments available in the literature.&lt;/div&gt;
Single-Channel Blind Source Separation of Spatial Aliasing Signal Based on Stacked-LSTM (2021)

Aiming at the problem of insufficient separation accuracy of aliased signals in space Internet satellite-ground communication scenarios, a stacked long short-term memory network (Stacked-LSTM) separation method based on deep learning is proposed. First, the coding feature representation of the mixed signal is extracted. Then, the long sequence input is divided into smaller blocks through the Stacked-LSTM network with the attention mechanism of the SE module, and the deep feature mask of the source signal is trained to obtain the Hadamard product of the mask of each source and the coding feature of the mixed signal, which is the encoding feature representation of the source signal. Finally, characteristics of the source signal is decoded by 1-D convolution to to obtain the original waveform. The negative scale-invariant source-to-noise ratio (SISNR) is used as the loss function of network training, that is, the evaluation index of single-channel blind source separation performance. The results show that in the single-channel separation of spatially aliased signals, the Stacked-LSTM method improves SISNR by 10.09∼38.17 dB compared with the two classic separation algorithms of ICA and NMF and the three deep learning separation methods of TasNet, Conv-TasNet and Wave-U-Net. The Stacked-LSTM method has better separation accuracy and noise robustness.
High Weissenberg number simulation of die swell for differential type viscoelastic model by the streamline‐upwind finite element method (1994)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Yoshifumi Kuwano, Toshihisa Kajiwara, Kazumori Funatsu; High Weissenberg number simulation of die swell for differential type viscoelastic model by the streamline‐upwind finite element method. J. Rheol. 1 May 1994; 38 (3): 755–756. https://doi.org/10.1122/1.550571 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
Supplementary Table 1 from Increases in Absolute Lymphocytes and Circulating CD4&lt;sup&gt;+&lt;/sup&gt; and CD8&lt;sup&gt;+&lt;/sup&gt; T Cells Are Associated with Positive Clinical Outcome of Melanoma Patients Treated with Ipilimumab (2023)

&lt;p&gt;Antibody panels used for flow cytometry* FoxP3 buffer (BD) was used to fix and permeabilize cells. Only frequencies of frequencies of CD4+, CD8+ T cells from Treg panel 1 and, CD14+ cells from MDSC panel 1 were included. 1 Panel 1 (n=14), 2 Panel 2 (n=68).&lt;/p&gt;
Somatic Mutations in <i>BRCA1</i> and <i>BRCA2</i> Could Expand the Number of Patients That Benefit From Poly (ADP Ribose) Polymerase Inhibitors in Ovarian Cancer (2010)

BRCA(1/2) somatic and germline mutations and expression loss are sufficiently common in ovarian cancer to warrant assessment for prediction of benefit in clinical trials of PARP1 inhibitors.
&lt;title&gt;Concurrent multilevel simulation of an ultrahigh-speed chemical imaging spectrometer: a design tool to decrease time and cost of prototyping&lt;/title&gt; (1997)

Dwindling research and development funds coupled with increasing customer demands and rapidly developing technologies present a difficult dilemma to systems developers. A current area of innovation is the integration of the abundant but diverse computer resources (both hardware and software) into practical and powerful computing environments to support the product development processes in the industrial and defense sectors. Edgewood has leveraged a number of existing resources to create a `virtual prototyping' environment based on the principles of Concurrent Multi-Level Simulation. We named our environment the `Computational Prototyping Network'.
Case History of Sea Dyke Construction Using Geotextile Mat (2008)

Geosynthetic damage has attracted a major attention since the introduction of geotextiles for civil construction applications. Geotextile is one of the most useful and effective polymer material in civil construction works and the main function of geotextile is separation, reinforcement, filtering and drainage. Recently, because of the shortage of natural rock, traditional forms of river and coastal structures have become very expensive to build and maintain. This study tries to suggest the method of estimating valid stitching rate and the methodology of sea dyke construction over soft soils for more reasonable application of geotextile mat by studying tensile strength, bursting strength, punching strength, tear strength that are considered when analyzing and designing geotextile mat of a field.
The Characteristic Analysis of Electroosmotic Micropump with Multistage Nano-Tubes (2014)

This study used porous alumina membranes with nanopores as nanopore channels and successfully constructed a single-stage/multistage nanotube electroosmotic micropump. The characteristics of electroosmotic nanotubes pump constructed using porous alumina membranes with varying pore sizes and at different stages were also analyzed. During the experiments, applying a multistage nanotube electroosmotic micropump with the same pore size at the two stages yielded a superior performance curve compared to that of the single-stage nanotube electroosmotic micropump. The flow volume and pressure difference of the pump increased rapidly with the input voltage. Thus, the flow volume of multistage nanotube electroosmotic micropump with the same pore size can be increased more than twice that of single-stage pumps. With a high input voltage, the multistage micropump showed a significant, approximately 4-fold increase.
Electrochemical Synthesis of Fluoro-Organic Compounds Using Iodine Compounds (2007)

The selective fluorination of alkyl iodide (1) having functional groups such as ketone, ester, chloro and tosylate takes place effectively at the iodide position in the presence of Et3N-3HF as an electrolyte affording alkyl fluoride (2) RF in high yields. Also, the iodofluorination of unsaturated hydrocarbons (3) has been successfully carried out using electro-chemically generated iodonium ion (I+) from a variety of iodide anion sources in the CH2Cl2 in Et3N-5HF electrolyte at room temperature to yield iodofluorination products (4).
Counting Efficiency of an Improved 30-Å Condensation Nucleus Counter (1991)

The ultrafine aerosol condensation nucleus counter (UFACNC) developed by Stolzenburg and McMurry (1990) has been improved. This new instrument can detect particles as small as 30 Å in nitrogen at a sample flow rate of 2.5 cm3·s−1. This flow rate is five times that of the earlier design with the same particle counting efficiency. An increased sample flow rate causes an increase in the arrival rate of detected particles. This improves accuracy in estimating the true particle concentration in ultraclean gas systems. In order to demonstrate its high accuracy the new UFACNC was used to measure the concentration of contaminant particles in ultrafiltered nitrogen. This represents the first accurate determination of ultrafine contamination levels in large ultraclean gas systems. The nitrogen was found to contain as few as 1.28 × 10−4 particles/cm3 (3.62/ft3). The higher volumetric flow rate of the new counter reduced the sample standard deviation of the measured count rate. Therefore, in the case of a low particulate count rate, the difference between the measured and instrument noise background count rates could be more accurately resolved. In addition, the new UFACNC was used to demonstrate a new technique for size classifying ultrafine contaminant particles using only a UFACNC, i.e., without a separate size classifier. The results demonstrate that ultrafine particle size distributions can be obtained directly from a stand-alone UFACNC
Relacorilant, a Selective Glucocorticoid Receptor Modulator, Induces Clinical Improvements in Patients With Cushing Syndrome: Results From A Prospective, Open-Label Phase 2 Study (2021)

The SGRM relacorilant provided clinical benefit to patients with CS without undesirable antiprogesterone effects or drug-induced hypokalemia.
Cauchy's Arm Lemma on a Growing Sphere (2008)

We propose a variant of Cauchy's Lemma, proving that when a convex chain on one sphere is redrawn (with the same lengths and angles) on a larger sphere, the distance between its endpoints increases. The main focus of this work is a comparison of three alternate proofs, to show the links between Toponogov's Comparison Theorem, Legendre's Theorem and Cauchy's Arm Lemma.
Accounting for Lateral Heterogeneity in a Pseudo Inverse Operator of the Extended Born (2018)

Summary Differential semblance optimization (DSO) is a popular method for the construction of a kinematically accurate velocity model for imaging applications. However, its gradient contains artifacts which affect the DSO performance. To resolve such a problem, a pseudo inverse operator under the assumption of laterally homogeneous background was used to generate the extended images for DSO. The laterally inhomogeneous version required extended images in the vertical offset direction, which is costly. We derive an extension of the approach to handle laterally inhomogeneous background media efficiently, and show that the term required for the laterally inhomogeneity treatment has a relatively small impact on the pseudo inverse operator for many cases.
A luminance adjusting algorithm for high resolution and high image quality AMOLED displays of mobile phone applications (2010)

A luminance adjusting algorithm using light sensing scanner is proposed for small-sized high resolution and high image quality active matrix organic light emitting diode (AMOLED) displays such as smartphone applications. By using simple pixel structure with the proposed algorithm, high aperture ratio in high resolution display can be achieved. Experimental results show that the standard deviation of luminance improves from 7.07 to 1.81 LSB when the proposed adjusting method is used to 3.5-inch AMOLED display with 8-bit gray scale.
Firn Densification: An Empirical Model (1980)

Abstract An empirical model of firn densification from the surface to the zone of pore close-off has been constructed. Fundamental rate equations have been derived for the first two stages of densification. In the first stage, for densities less than 0.55 Mg m −3 , the densification rate is proportional to the mean annual accumulation times the term ( ρ i − ρ ), where ρ is the density of the snow and ρ i is the density of pure ice. The densification rate in the second stage, where 0.55 Mg m −3 &lt; ρ &lt; 0.8 Mg m −3 , is proportional to the square root of the accumulation rate and to ( ρ i− ρ ). Depth–density and depth–age calculations from this model are compared with observation. Model accumulation rates are within about 20% of values obtained by other techniques. It is suggested that depth intervals of constant density in some Antarctic cores may represent a synchronous event in the 1880 ’s when ten times the normal accumulation fell within a year or two.
An algebra for fine-grained integration of XACML policies (2009)

Collaborative and distributed applications, such as dynamic coalitions and virtualized grid computing, often require integrating access control policies of collaborating parties. Such an integration must be able to support complex authorization specifications and the fine-grained integration requirements that the various parties may have. In this paper, we introduce an algebra for fine-grained integration of sophisticated policies. The algebra, which consists of three binary and two unary operations, is able to support the specification of a large variety of integration constraints. To assess the expressive power of our algebra, we introduce a notion of completeness and prove that our algebra is complete with respect to this notion. We then propose a framework that uses the algebra for the fine-grained integration of policies expressed in XACML. We also present a methodology for generating the actual integrated XACML policy, based on the notion of Multi-Terminal Binary Decision Diagrams.
Implications of the PD-1/B7-H1 receptor-ligand system in Alzheimer's Disease (2008)

Alzheimer's disease is characterized by the formation of amyloid plaques, neurofibrillar tangles and chronic neuroinflammation throughout the brain leading to activation of astrocytes and immune regulatory microglia of the brain. Members of the CD28 family of transmembrane receptors as well as their ligands of the B7 family have been shown to be involved in costimulatory and/or inhibitory functions of immune responses. Recently, expression of B7-H1 in microglia and astrocytes have been implicated in immune responses in the brain. We therefore investigated the importance of B7-H1 and its receptor PD-1 in the context of Alzheimer's disease. We observed decreased phagocytosis of amyloid beta by primary microglia derived from PD-1 as well as B7-H1 knock out mice. Phagocytosis of amyloid beta could be blocked using an B7-H1 specific antibody. Immunhistochemical analysis of brain sections of wild type and APPPS1 overexpressing mice with antibodies against PD-1, CD11b and amyloid beta demonstrated a colocalization of these proteins. The results suggest a role of PD-1 in the inflammatory reaction accompanied with AD as well as in the regulation of amyloid beta clearance.
Functional reactive programming as a hybrid system framework (2004)

In previous work we presented functional reactive programming (FRP), a general framework for designing hybrid systems and developing domain-specific languages for related domains. FRP's synchronous dataflow features, like event driven switching, supported by higher-order lazy functional abstractions of Haskell allows rapid development of modular and reusable specifications. In this paper, we look at more closely to the relation of arrowized FRP (AFRP), the FRP implementation, and formal specification of hybrid systems. We show how a formally specified hybrid system can be expressed in FRP and present a constructive proof showing that, for a subset of AFRP programs, there is a corresponding formal hybrid system specification.
Electronic States and Excitations in Polymers (1981)

The most common probe of the electronic structure of matter is light. However, for many polymeric materials the fundamental electronic excitation spectrum is beyond the range of common optical spectrometers. For these materials electron energy loss spectroscopy is a particularly attractive technique for measuring the spectrum of electronic excitations, thus providing key information for the basic understanding of the nature of the electronic states. The experiments reported here measured energy loss spectra of an 80 keV electron beam transmitted through thin samples (~100 nm thick) which were prepared by standard solvent casting techniques or polymerized in thin film form. The special purpose high resolution energy loss spectrometer used in these studies was operated with a resolution of 0.1 eV. Spectra were recorded as a function of scattering angle (or momentum transfer) over the energy range 0.2 to 400 eV, thus encompassing both valence and core electronic excitations. Radiation induced changes
Switching of <i>H</i><sub>∞</sub> controller under constraints and decision of controller state at instance of the controller switching (2002)

Abstract In real control systems, certain constraints are placed on the input, state, and output values. If such constraints are violated, the system may become unstable, in a worst‐case scenario. One of the promising approaches to solving this problem is to switch the controller according to the state of the closed‐loop system. No useful design strategy for each controller, however, has yet been developed. In addition, the determination of the controller state at the instant of controller switching has not been investigated. First, this paper presents a new design methodology which merges the switching control and H ∞ controller design into one design algorithm. Second, this paper presents a way of determining the controller state at the instant of controller switching. Finally, the proposed method is applied to force control of a one‐DOF manipulator in order to demonstrate the usefulness of the proposed method. © 2002 Wiley Periodicals, Inc. Electr Eng Jpn, 142(2): 68–75, 2003; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/eej.10082