gebhart/patrepeval huggingface dataset:
A Prospective Study of Statin Drug Use and Lower Urinary Tract Symptoms in Older Men (2013)

Dyslipidemia and chronic inflammation may play a role in the cause of lower urinary tract symptoms (LUTS) in older men. Use of statin drugs, which are prescribed to lower cholesterol and appear to reduce inflammation, may decrease the incidence or progression of LUTS. The associations of statin drug use with LUTS incidence and progression were prospectively evaluated in the Health Professionals Follow-up Study from 1992 to 2008. Hazard ratios and 95% confidence intervals of incident LUTS (from no or a low International Prostate Symptom Score (IPSS) of 0-7 to a moderate or worse IPSS of ≥15; n = 5,790 cases in 24,715 men) and of LUTS progression (from modest IPSS of 8-14 to severe IPSS of ≥20; n = 2,238 cases in 8,709 men) were calculated comparing current statin use with nonuse. The hazard ratios of LUTS incidence and progression comparing current use to nonuse were greater than 1. However, when comparisons were restricted to participants who used drugs to treat hypertension (a surrogate for uptake of medical care), statin use was not associated with LUTS incidence (hazard ratio = 1.02, 95% confidence interval: 0.94, 1.12) or progression (hazard ratio = 0.98, 95% confidence interval: 0.85, 1.13). Thus, statin use is unlikely to beneficially influence the development or course of LUTS. The present study highlights a methodological issue (confounding) that must be addressed in observational studies on the use of common drugs for indications other than the primary use.
A direct conversion CMOS transceiver for IEEE 802.11a WLANs (2003)

A 0.18μm CMOS transceiver fully compliant with IEEE 802.11a in the U-NII band (5.15 - 5.35GHz) achieves a sensitivity of -69dBm and an EVM of -29.3dB for 64 QAM. Power dissipation is 171 mW in RX and 138mW in TX using a 1.8V supply.
Temperature Dependence of Quality Factors at High Frequencies in MEMS Gyroscopes (2023)

An efficient simulation approach for obtaining the temperature-dependent thermoelastic damping (TED) quality factors of the mechanical modes in complex microelectromechanical systems (MEMS) gyroscopes is reported. It is shown that the temperature dependence of TED in an application-relevant temperature range can be obtained by a Taylor expansion of the full solution around room temperature. Our approach is much faster than performing the full simulation at every temperature. We find good agreement of our simulation results with measured data and show that TED is highly relevant for the overall quality factors of higher order modes.
Cell-adhesion molecules and metalloproteinases: a linked role in tumour cell invasiveness (1994)

Conference Article| February 01 1994 Cell-adhesion molecules and metalloproteinases: a linked role in tumour cell invasiveness Garry J. Rucklidge; Garry J. Rucklidge *The Rowett Research Institute, Aberdeen AB2 9SB, U.K. Search for other works by this author on: This Site PubMed Google Scholar Klaus Edvardsen; Klaus Edvardsen †The Protein Laboratory, Panum Institute, University of Copenhagen, Denmark Search for other works by this author on: This Site PubMed Google Scholar Elisabeth Bock Elisabeth Bock †The Protein Laboratory, Panum Institute, University of Copenhagen, Denmark Search for other works by this author on: This Site PubMed Google Scholar Author and article information Publisher: Portland Press Ltd Received: September 21 1993 Online ISSN: 1470-8752 Print ISSN: 0300-5127 © 1994 Biochemical Society1994 Biochem Soc Trans (1994) 22 (1): 63–68. https://doi.org/10.1042/bst0220063 Article history Received: September 21 1993 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Citation Garry J. Rucklidge, Klaus Edvardsen, Elisabeth Bock; Cell-adhesion molecules and metalloproteinases: a linked role in tumour cell invasiveness. Biochem Soc Trans 1 February 1994; 22 (1): 63–68. doi: https://doi.org/10.1042/bst0220063 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search Keywords: ECM; extracellular matrix, MMP, matrix metalloproteinase, PG, proteoglycan, TIMP; tissue inhibitor of metalloproteinases, NCAM, neural cell-adhesion molecule, RGD, arginine-glycine-aspartic acid, PMN, polymorphonuclear This content is only available as a PDF. © 1994 Biochemical Society1994 Article PDF first page preview Close Modal You do not currently have access to this content.
Mossbauer investigation of the crystallographic phase transition in Cs<sub>2</sub>FeCl<sub>5</sub>.H<sub>2</sub>O (1987)

The antiferromagnetic salt Cs2FeCl5.H2O is observed to undergo a crystallographic phase transition at TC=151.5+or-0.5 K in which the electric field gradient tensor becomes symmetric in the high-temperature phase. The order of this phase change is discussed. At temperatures below TC the quadrupole splitting has a saturation value of 0.295+or-0.005 mm s-1. Values of the Debye temperature for the material were obtained by relating the temperature variation of the spectrum centre shift and resonant absorption area to the second-order Doppler shift and the recoil-free fraction respectively.
New DCE-MRI parameters to quantify the vascular changes induced by sunitinib treatment in renal carcinoma tumors (2014)

To develop new dynamic contrast enhanced (DCE) magnetic resonance imaging (MRI) parameters to quantify the vascular effects of different doses of the antiangiogenic drug sunitinib on renal cell carcinoma (RCC) kidney tumors in mice. Mice bearing established RCC xenograft tumors were treated with sunitinib doses of 10, 20 or 40 mg/kg/day (SU10, SU20 or SU40 respectively) or treated with vehicle only (control). New DCE parameters, contrast agent uptake to the peak (AUCtp), time to peak concentration (TTP), washout slope (Nslope) and full width half maximum (FWHM), were obtained from T1-weighted images. These parameters were quantified for tumor-bearing kidneys and normal kidneys. Treatments with SU20 and SU40 caused increased perfusion in the tumor core compared to control and SU10. Kidney tumors treated with SU20 had an almost identical pattern of contrast agent uptake rate, peak and clearance as those observed in normal kidneys. The effect of SU20 on normal kidneys was milder than that observed with SU40. Treatment with SU40 caused increased contrast agent uptake by the cortex of the normal kidneys compared to the normal kidneys in control and SU10. FWHM also provided new information about the effect of different treatment doses and showed that kidney tumors treated with SU20 have almost the same values of FWHM as the normal kidneys in control mice. The new DCE parameters, including AUCtp, Nslope and FWHM, have the potential to give a precise description of the treatment effect not only in the whole mouse kidney but also in different regions inside the kidney.
Balloon assisted treatment of intracranial aneurysms: the conglomerate coil mass technique (2009)

Endovascular techniques for the treatment of intracranial aneurysms have rapidly evolved over the past 15 years since the introduction and subsequent US Food and Drug administration approval of the Gugleilmi detachable coil. During this period, a number of different coil designs and adjunctive devices have been developed to facilitate the treatment of more complex and challenging cerebral aneurysms. One such adjunctive device, the hypercompliant occlusion balloon, can be temporarily inflated during the delivery of embolization coils to prevent their prolapse into the parent vessel. This technique, known as balloon assisted treatment (BAT), remains somewhat controversial as many operators do not incorporate this approach into their practice, favoring stent supported techniques instead. Moreover, those operators who do practice BAT use a variety of different approaches. In this review, we discuss the theoretical concepts underlying BAT, the potential advantages and disadvantages of this approach and finally the technical evolution of BAT in our endovascular practice.
Longitudinal Assessment of Chlorpyrifos Exposure in Farmers and Residents of an Italian Alpine Region (2021)

Abstract The aim of this study was to obtain a longitudinal evaluation of the exposure to chlorpyrifos (CP) and chlorpyrifos-methyl (CPM) in agricultural workers in South Tyrol and in a residential group living in the same area. CP and CPM are widely used pesticides in agriculture. Biological monitoring of CP and CPM exposure in humans can be achieved by analyzing urinary levels of 3,5,6-trichloro-2-pyridinol (TCPy). TCPy a metabolite of CP and CPM which is produced by a two-step metabolic transformation. Between May 14th, 2014 and March 16th, 2015 we conducted a longitudinal study on 28 farmers actively working in spray pesticide treatment and 43 non-farmers living in the same agricultural area of South Tyrol (Italy). Urine samples were collected at two time points: during the pesticide treatment period and in a temporally distant season that should guarantee metabolite clearance. We developed and validated a liquid chromatography-tandem mass spectrometry (LC–MS/MS) method for the determination of urinary TCPy levels. During the treatment season, both farmers and residents showed higher TCPy levels (median = 6.8 and 6.73 ug/g creatinine, respectively) than during the non-treatment season (median = 2.54 and 3.22 ug/g creatinine, respectively), suggesting a similar effect of the pesticide spraying on both groups. However, the observed TCPy levels resulted in a daily CP and CPM intake well below the limits recommended by FAO/WHO. During the non-treatment season, non-farmers showed higher TCPy levels values than farmers, suggesting the existence of TCPy of other unmeasured sources of exposure not considered in this study. This suggests that, for a comprehensive evaluation of the risks associated with TCPy exposure, additional sources should be identified in addition to CP and CPM pesticides.
Optically pumped type-II antimonide mid-IR lasers with integrated absorber layers (2002)

We report on optically-pumped mid-infrared (3.4 - 4.5 /spl mu/m) lasers based on InAs/InGaSb/InAs type-II quantum wells that are periodically inserted into the InGaAsSb waveguide designed to absorb the 1.85 /spl mu/m pump radiation. The integrated absorber layers allow the decoupling of pump absorption from the type-II quantum wells, and efficiently supply carries into these wells by ambipolar diffusion. These type-II integrated absorber lasers exhibit high quantum efficiency and high characteristic temperature associated with lasing threshold.
Block of I<sub>Ks</sub> Does Not Induce Early Afterdepolarization Activity but Promotes β‐Adrenergic Agonist‐Induced Delayed Afterdepolarization Activity (2000)

Our results indicate that I(Ks) block alone or in combination with beta-adrenergic stimulation does not induce EADs in any of the four canine ventricular tissue types, but that the combination of the two induces DADs as well as accentuated dispersion of repolarization.
From Beetles in Nature to the Laboratory: Actuating Underwater Locomotion on Hydrophobic Surfaces (2015)

The controlled wetting and dewetting of surfaces is a primary mechanism used by beetles in nature, such as the ladybird and the leaf beetle for underwater locomotion.1 Their adhesion to surfaces underwater is enabled through the attachment of bubbles trapped in their setae-covered legs. Locomotion, however, is performed by applying mechanical forces in order to move, attach, and detach the bubbles in a controlled manner. Under synthetic conditions, however, when a bubble is bound to a surface, it is nearly impossible to maneuver without the use of external stimuli. Thus, actuated wetting and dewetting of surfaces remain challenges. Here, electrowetting-on-dielectric (EWOD) is used for the manipulation of bubble-particle complexes on unpatterned surfaces. Bubbles nucleate on catalytic Janus disks adjacent to a hydrophobic surface. By changing the wettability of the surface through electrowetting, the bubbles show a variety of reactions, depending on the shape and periodicity of the electrical signal. Time-resolved (μs) imaging of bubble radial oscillations reveals possible mechanisms for the lateral mobility of bubbles on a surface under electrowetting: bubble instability is induced when electric pulses are carefully adjusted. This instability is used to control the surface-bound bubble locomotion and is described in terms of the change in surface energy. It is shown that a deterministic force applied normal can lead to a random walk of micrometer-sized bubbles by exploiting the phenomenon of contact angle hysteresis. Finally, bubble use in nature for underwater locomotion and the actuated bubble locomotion presented in this study are compared.
On the Gaussian Multiple Access Wiretap Channel and the Gaussian Wiretap\n Channel with a Helper: Achievable Schemes and Upper Bounds (2017)

We study deterministic approximations of the Gaussian two-user multiple\naccess wiretap channel (G-MAC-WT) and the Gaussian wiretap channel with a\nhelper (G-WT-H). These approximations enable results beyond the recently shown\n2/3 and 1/2 secure degrees of freedom (s.d.o.f.) for the G-MAC-WT and the\nG-WT-H, respectively. While the s.d.o.f. were obtained by real interference\nalignment, our approach uses signal-scale alignment. We show achievable schemes\nwhich are independent of the rationality of the channel gains. Moreover, our\nresults can differentiate between channel strengths, in particular between both\nusers, and establishes secrecy rates dependent on this difference. We can show\nthat the resulting achievable secrecy rates tend to the s.d.o.f. for vanishing\nchannel gain differences. Moreover, we extend previous and develop new\ntechniques to prove general s.d.o.f. bounds for varying channel strengths and\nshow that our achievable schemes reach the bounds for certain channel gain\nparameters. We believe that our analysis is the next step towards a\nconstant-gap analysis of the G-MAC-WT and the G-WT-H.\n
Ultrasound contrast agent loaded with nitric oxide as a theranostic microdevice (2015)

The current study describes novel multifunctional polymer-shelled microbubbles (MBs) loaded with nitric oxide (NO) for integrated therapeutic and diagnostic applications (ie, theranostics) of myocardial ischemia. We used gas-filled MBs with an average diameter of 4 μm stabilized by a biocompatible shell of polyvinyl alcohol. In vitro acoustic tests showed sufficient enhancement of the backscattered power (20 dB) acquired from the MBs' suspension. The values of attenuation coefficient (0.8 dB/cm MHz) and phase velocities (1,517 m/s) were comparable with those reported for the soft tissue. Moreover, polymer MBs demonstrate increased stability compared with clinically approved contrast agents with a fracture threshold of about 900 kPa. In vitro chemiluminescence measurements demonstrated that dry powder of NO-loaded MBs releases its gas content in about 2 hours following an exponential decay profile with an exponential time constant equal to 36 minutes. The application of high-power ultrasound pulse (mechanical index =1.2) on the MBs resuspended in saline decreases the exponential time constant from 55 to 4 minutes in air-saturated solution and from 17 to 10 minutes in degassed solution. Thus, ultrasound-triggered release of NO is achieved. Cytotoxicity tests indicate that phagocytosis of the MBs by macrophages starts within 6-8 hours. This is a suitable time for initial diagnostics, treatment, and monitoring of the therapeutic effect using a single injection of the proposed multifunctional MBs.
Safety and effectiveness of a prothrombin complex concentrate in approved and off‐label indications (2019)

4F-PCC was effective as adjuvant treatment with an acceptable safety profile, not only for the emergent reversal of VKAs but also for refractory coagulopathy associated with major bleeding.
Contextual Inter-modal Attention for Multi-modal Sentiment Analysis (2018)

Multi-modal sentiment analysis offers various challenges, one being the effective combination of different input modalities, namely text, visual and acoustic. In this paper, we propose a recurrent neural network based multi-modal attention framework that leverages the contextual information for utterance-level sentiment prediction. The proposed approach applies attention on multi-modal multi-utterance representations and tries to learn the contributing features amongst them. We evaluate our proposed approach on two multi-modal sentiment analysis benchmark datasets, viz. CMU Multi-modal Opinion-level Sentiment Intensity (CMU-MOSI) corpus and the recently released CMU Multi-modal Opinion Sentiment and Emotion Intensity (CMU-MOSEI) corpus. Evaluation results show the effectiveness of our proposed approach with the accuracies of 82.31% and 79.80% for the MOSI and MOSEI datasets, respectively. These are approximately 2 and 1 points performance improvement over the state-of-the-art models for the datasets.
ALKALI CATION CHELATION IN COLD β-O-4 TETRALIGNOL COMPLEXES (2016)

We\nemploy cold ion spectroscopy (UV action and IR–UV double\nresonance) in the gas phase to unravel the qualitative structural\nelements of G-type alkali metal cationized (X = Li&lt;sup&gt;+&lt;/sup&gt;, Na&lt;sup&gt;+&lt;/sup&gt;, K&lt;sup&gt;+&lt;/sup&gt;) tetralignol complexes connected by β-O-4\nlinkages. The conformation-specific spectroscopy reveals a variety\nof conformers, each containing distinct infrared spectra in the OH\nstretching region, building on recent studies of the neutral and alkali\nmetal cationized β-O-4 dimers. The alkali metal ion is discovered\nto bind in penta-coordinate pockets to ether and OH groups involving\nat least two of the three β-O-4 linkages. Different binding\nsites are distinguished from one another by the number of M&lt;sup&gt;+&lt;/sup&gt;···OH···O interactions present in the\nbinding pocket, leading to characteristic IR transitions appearing\nbelow 3550 cm&lt;sup&gt;–1&lt;/sup&gt;. This interaction is mitigated in\nthe major conformer of the K&lt;sup&gt;+&lt;/sup&gt; adduct, demonstrating a clear\nimpact of the size of the charge center on the three-dimensional structure\nof the tetramer.
Gain enhanced millimetre-wave beam-switching Rotman lens antenna designs on LCP (2017)

Compact and low-cost antenna arrays with beam-steering or beam-switching are needed for emerging millimeter-wave communication systems such as 5G and WLAN at the 60 GHz frequency band. The design, manufacturing and measurement results for a 60 GHz beam-switching Rotman lens integrated with a 4×8 patch antenna array are presented. Active versions with integrated amplifiers are also developed. The presented design can electrically switch between five different beam directions −23°, −12°, 0°, 12° and 23°. Antenna gains of 8 dBi and 26.5 dBi are measured at 60 GHz for passive and active beam-switching Rotman lens antennas.
Uses of polyimide for micromachining applications (2002)

In this paper, applications of polyimide materials to micromachining technology is reviewed. First, the use of both photosensitive and nonphotosensitive polyimides as electroplating molds for the fabrication of thick and high aspect ratio metallic microstructures is presented, Electroplated microstructures of different metals realized using these technologies are shown. In addition, various applications of this technology that have been realized are discussed. Second, the use of polyimide materials as integral parts of micromachined devices is presented. Emphasis is given to the development of a piezoresistive composite of polyimide/graphite for sensor applications.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Critical Role of the IFN-Stimulated Gene Factor 3 Complex in TLR-Mediated IL-27p28 Gene Expression Revealing a Two-Step Activation Process (2010)

In myeloid dendritic cells, activation of the IL-27p28 gene is selectively induced by ligands of TLR4 or TLR3, both coupled to the Toll/IL-1R-related domain-containing adaptor-inducing IFN/IFN regulatory factor (IRF)3 pathway. In response to both ligands, autocrine type 1 IFN production was required for optimal IL-27p28 expression. Type I IFN signaling was necessary for sustained IRF1 activation and formation of the IRF9-containing IFN-stimulated gene factor 3 complex. Indeed, we demonstrated that IRF1 and IRF9 are sequentially activated and recruited to the IL-27p28 IFN-stimulated regulatory element site. Involvement of IRF1 and IRF9 in the induction of IL-27p28 was confirmed in vitro and upon in vivo exposure to TLR ligands. Thus, in response to TLR4 or TLR3 ligation, the initial induction of the IL-27p28 gene depends on the recruitment of IRF1 and IRF3, whereas transcriptional amplification requires recruitment of the IFN-stimulated gene factor 3 complex. These results highlight the complex molecular interplay between TLRs and type I IFNs for the control of IL-27 synthesis.
4‐Methyl‐1,2,4‐triazol‐3‐yl Heterocycle as an Alternative to the 1‐Methylimidazol‐5‐yl Moiety in the Farnesyltransferase Inhibitor ZARNESTRA. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Microchip Electrophoresis of Tagged Probes Incorporated with One-Colored ddNTP for Analyzing Single-Nucleotide Polymorphisms (2003)

We demonstrate a simple and rapid method for SNP typing, allele frequency determination, and trace mutant analysis that works with even an inexpensive detection system. This method is based on microchip electrophoresis of tagged probes incorporated with one-colored ddNTP (METPOC). The assay uses dye terminator incorporation into a pair of probes of different lengths specific to wild- and mutant-type targets, respectively. They are hybridized to the targets prior to ddNTP-Cy-5 incorporation, which occurs only for a matched probe-target duplex. Because the extension reactions for the two probes are carried out simultaneously in one tube and the products from both probes are analyzed in one channel by one-color fluorescence detection, an accurate comparative analysis of SNPs is possible. SNP typing as well as allele frequency determination in the range above 0.1% can easily be carried out using a commercial microchip electrophoresis system in a few minutes.
Wissenschaft und Kultur in Bibliotheken, Museen und Archiven (2005)

The Festschrift for the 65th birthday of the president of the Stiftung Preußischer Kulturbesitz (Foundation for Prussian Cultural Heritage) contains more than 60 contributions by individuals from culture and politics, libraries and publishers. Among the contributors are Heinz Berggruen, W. Michael Blumenthal, Karl Dedecius, Wolfgang Frühwald, Vittorio E. Klostermann, Norbert Lammert, Hermann Leskien, Jutta Limbach, Wolf D. Lucius, Michael Naumann, June Newton, Elisabeth Niggemann, Paul Raabe, Petra Roth, Henning Schulte-Noelle, Ruth Wagner, Christina Weiss, Karin von Welck, Christoph Wolff and Klaus Wowereit, et al. The subjects cover a spectrum ranging from the visual arts to museum designs and many aspects of books, publishering, librarianship and the promotion of culture.
Aluminium Implantation in Germanium: Uphill Diffusion, Electrical Activation, and Trapping (2012)

This study presents a broad investigation on Al implantation in crystalline Ge. We show that up to 600 degrees C, Al does not diffuse and a remarkable electrical activation of similar to 1 x 10(20) cm(-3) is obtained. For higher annealing temperatures (from 700 to 800 degrees C), Al shows a significant diffusion towards the bulk and an unexpected uphill diffusion next to the surface, where the electrical measurements indicate a significant deactivation of Al. Both these latter observations are explained in terms of the presence of dopant traps, able to make immobile and electrically inactive the dopant next to the surface. (C) 2012 The Japan Society of Applied Physics