1892 PT2 SUBSTAGING IN UROTHELIAL CARCINOMA OF THE BLADDER: DEEP MUSCLE INVASION IS ASSOCIATED WITH WORSE OUTCOME (2011)

You have accessJournal of UrologyBladder Cancer: Staging1 Apr 20111892 PT2 SUBSTAGING IN UROTHELIAL CARCINOMA OF THE BLADDER: DEEP MUSCLE INVASION IS ASSOCIATED WITH WORSE OUTCOME Derya Tilki, Oliver Reich, Pierre Karakiewicz, Giacomo Novara, Wassim Kassouf, Yves Fradet, Vincenzo Ficarra, Michael Seitz, Eila Skinner, Robert Svatek, Yair Lotan, Arthur Sagalowsky, Christian Stief, and Shahrokh Shariat Derya TilkiDerya Tilki Munich, Germany More articles by this author , Oliver ReichOliver Reich Munich, Germany More articles by this author , Pierre KarakiewiczPierre Karakiewicz Montreal, Canada More articles by this author , Giacomo NovaraGiacomo Novara Padua, Italy More articles by this author , Wassim KassoufWassim Kassouf Montreal, Canada More articles by this author , Yves FradetYves Fradet Quebec, Canada More articles by this author , Vincenzo FicarraVincenzo Ficarra Padua, Italy More articles by this author , Michael SeitzMichael Seitz Munich, Germany More articles by this author , Eila SkinnerEila Skinner Los Angeles, CA More articles by this author , Robert SvatekRobert Svatek Dallas, TX More articles by this author , Yair LotanYair Lotan Dallas, TX More articles by this author , Arthur SagalowskyArthur Sagalowsky Dallas, TX More articles by this author , Christian StiefChristian Stief Munich, Germany More articles by this author , and Shahrokh ShariatShahrokh Shariat New York, NY More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2011.02.2016AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES To compare the cancer-specific outcomes of patients with pathologic T2 urothelial carcinoma of the bladder (UCB) at radical cystectomy (RC) in a large international cohort of patients. METHODS The records of patients treated with RC for UCB at six centers were reviewed. Of the 2605 reviewed patients, 565 (21.7%) had pT2 disease. None of the patients received pre-operative systemic chemotherapy or radiotherapy. RESULTS Median patient age in the entire group was 66.2 years. Of the 565 patients with pT2 UCB, 249 patients (44.1 %) had substage pT2a and 316 patients (55.9%) had pT2b. 111 patients (19.6%) had metastases to regional lymph nodes. Median follow-up was 50.5 months. Recurrence-free [73.2% vs 58.7%] and cancer-specific survival [78.0% vs 65.1%] estimates were significantly better for pT2a patients compared to those with pT2b (p=0.002 and p=0.001, respectively). pT2 substaging was associated with worse recurrence-free and cancer specific survival after adjusting for the effects of standard pathologic features (p=0.011 and p=0.006, respectively). The statistical significance of these associations was reconfirmed in subgroup analysis limited to those patients with pathologically negative lymph nodes. CONCLUSIONS In this large international cohort pathologic substaging helped to stratify patients with lymph node negative pT2 UCB into statistically significantly different risk groups. These data support the value of the current AJCC TNM staging. © 2011 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 185Issue 4SApril 2011Page: e757 Advertisement Copyright & Permissions© 2011 by American Urological Association Education and Research, Inc.MetricsAuthor Information Derya Tilki Munich, Germany More articles by this author Oliver Reich Munich, Germany More articles by this author Pierre Karakiewicz Montreal, Canada More articles by this author Giacomo Novara Padua, Italy More articles by this author Wassim Kassouf Montreal, Canada More articles by this author Yves Fradet Quebec, Canada More articles by this author Vincenzo Ficarra Padua, Italy More articles by this author Michael Seitz Munich, Germany More articles by this author Eila Skinner Los Angeles, CA More articles by this author Robert Svatek Dallas, TX More articles by this author Yair Lotan Dallas, TX More articles by this author Arthur Sagalowsky Dallas, TX More articles by this author Christian Stief Munich, Germany More articles by this author Shahrokh Shariat New York, NY More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...