gebhart/patrepeval huggingface dataset:
Carcinogenic Effects of Adjuvant Tamoxifen Treatment and Radiotherapy for Early Breast Cancer (1992)

The occurrence of new primary tumours among postmenopausal patients with primary breast cancer subsequent to adjuvant treatment in Denmark was assessed by linkage to the cancer registry. Following primary surgery, patients in low risk of recurrence (n = 1,828) received no further treatment while patients in high risk randomly received either adjuvant radiotherapy alone (n = 846) or radiotherapy + tamoxifen 30 mg daily for 48 weeks (n = 864). With a median follow-up of 8 years, the incidence of tumours in the contralateral breast was similar among tamoxifen-treated, and non-treated high-risk patients even after adjusting for tumours arising within the first year. The standardized incidence ratio for endometrial cancer was 1.9 (95% confidence interval 0.8-3.9) among tamoxifen treated, the cumulative incidence 1% compared to 0.3% among non-treated patients (p = 0.11). The cumulative risk of non-lymphocytic leukaemia was 0.9% and 0.1% among irradiated and non-irradiated patients respectively (p = 0.4). Prolonged follow-up of tamoxifen-treated patients with regard to new tumours is recommended.
&lt;title&gt;Off-road vehicle locomotion using Bekker's model&lt;/title&gt; (2000)

Bekker's Derived Terramechanics Model (BDTM) is an analytical tool for evaluating vehicle off-road mobility. BDTM has been developed using Bekker's equations for vehicle soil interactions. He developed the bevameter technique to measure mechanical strength characteristics for many soil and snow conditions. BDTM is in a spreadsheet format, and its primary purpose is to compare mobility characteristics for robotic track and wheeled vehicles under different terrain conditions. Bekker's model is a simple, linear one degree-of-freedom (1-DOF) model, which assumes that in a perfectly cohesive soil (i.e. clay), soil thrust is only a function of contact surfacearea. The model also assumes that for a perfection cohesionless or frictional soil (i.e. dry sand), soil thrust is a function of vehicular weight. This paper attempts to compare the mobility characteristics of wheeled vs. track vehicles for different size, weight and terrain conditions.
Motion and Structure Information Based Adaptive Weighted Depth Video Estimation (2015)

This paper presents a novel depth video estimation method, which improves estimation property and refines the temporal consistency and spatial accuracy at the same time. The main idea is to incorporate more useful motion and structure information into depth estimation. First, an adaptive weight is calculated based on the motion information of adjacent frames and attached to a temporal term to update the energy function, thus reducing the matching errors and improving temporal consistency. Second, the depth continuity/discontinuity in spatial domain is properly judged by combining the edges of initial depth map and color segmentation, and used in the refinement strategy. Finally, we evaluate the performance of our algorithm with several public stereoscopic video sequences. Experimental results show that the qualities of depth video and synthesized virtual view are all improved.
Enhancement of the Sub-Band-Gap Photoconductivity in ZnO Nanowires through Surface Functionalization with Carbon Nanodots (2018)

We report on the surface functionalization of ZnO nanowire (NW) arrays by attachment of carbon nanodots (C-dots) stabilized by polyethylenimine. The photoconductive properties of the ZnO NWs/C-dots devices were investigated under photoexcitation with photon energies below and above the ZnO band gap. The results indicate an increased photoresponse of the functionalized devices in the visible spectral range, as well as enhanced UV photoconductivity. This is attributed to the fast injection of photoexcited electrons from the C-dots into the conduction band of the ZnO NWs, and the subsequent slower desorption of molecular species from the NW surface, which reduces the surface depletion region in the NWs. The surface functionalization of the ZnO NWs with carbon nanodots also impacts the dynamics of the photocurrent decay, inducing a slower relaxation of the photogenerated charge carriers.
Ultra-Long Range Plasmon Waves in Finite Thickness Gold Metal Film (2006)

Our recent study shows that the travel ranges of surface plasmon waves guided by finite thickness gold metal films or micro-strips can be extended several orders of magnitude longer by engineering the plasmon waveguide structures. Article not available.
Contribution of mitral annular excursion and shape dynamics to total left ventricular volume change (2004)

The mitral annulus (MA) has a complex shape and motion, and its excursion has been correlated to left ventricular (LV) function. During the cardiac cycle the annulus' excursion encompasses a volume that is part of the total LV volume change during both filling and emptying. Our objective was to evaluate the contribution of MA excursion and shape variation to total LV volume change. Nine healthy subjects aged 56 +/- 11 (means +/- SD) years underwent transesophageal echocardiography (TEE). The MA was outlined in all time frames, and a four-dimensional (4-D) Fourier series was fitted to the MA coordinates (3-D+time) and divided into segments. The annular excursion volume (AEV) was calculated based on the temporally integrated product of the segments' area and their incremental excursion. The 3-D LV volumes were calculated by tracing the endocardial border in six coaxial planes. The AEV (10 +/- 2 ml) represented 19 +/- 3% of the total LV stroke volume (52 +/- 12 ml). The AEV correlated strongly with LV stroke volume (r = 0.73; P < 0.05). Peak MA area occurred during middiastole, and 91 +/- 7% of reduction in area from peak to minimum occurred before the onset of LV systole. The excursion of the MA accounts for an important portion of the total LV filling and emptying in humans. These data suggest an atriogenic influence on MA physiology and also a sphincter-like action of the MA that may facilitate ventricular filling and aid competent valve closure. This 4-D TEE method is the first to allow noninvasive measurement of AEV and may be used to investigate the impact of physiological and pathological conditions on this important aspect of LV performance.
Electrical measurements on capacitor sizes in the submicron regime for the characterization of real memory cell capacitors (2001)

Abstract Pb(Zr,Ti)O3 (PZT) and SrBi2Ta2O9 (SBT) are promising candidates for the use as cell capacitor materials in ferroelectric non-volatile memory devices (FeRAMs). For years it has been an outstanding challenge to perform electrical measurements on samples with pad sizes which are equal to the pad size of real cell capacitors of integrated memory devices. Up to now either larger sample capacitors or an array of several hundred capacitors in parallel could be investigated with typical measurement techniques [1]. But, both measurements can hardly detect the failure of a single capacitor in the submicron range.
Memantine for Disruptive Behavior in Autistic Disorder (2006)

Sir: Studies from the United States suggest that the lifetime prevalence of both severe traumatic events and posttraumatic stress disorder (PTSD) is higher in people with schizophrenia than in the general population. 1 It has been suggested that comorbidity with PTSD is characterized by more severe schizophrenic symptoms and could be associated with poorer outcome. 2 Psychiatric inpatient treatment under some circumstances can be experienced as traumatic and can cause PTSDlike symptoms, particularly if compulsory interventions such as involuntary treatment, seclusion, and restraint are necessary. Patients with schizophrenic disorders are the patients most frequently exposed to such interventions.
Structure-aware Generative Network for 3D-Shape Modeling (2018)

We present SAGNet, a structure-aware generative model for 3D shapes. Given a set of segmented objects of a certain class, the geometry of their parts and the pairwise relationships between them (the structure) are jointly learned and embedded in a latent space by an autoencoder. The encoder intertwines the geometry and structure features into a single latent code, while the decoder disentangles the features and reconstructs the geometry and structure of the 3D model. Our autoencoder consists of two branches, one for the structure and one for the geometry. The key idea is that during the analysis, the two branches exchange information between them, thereby learning the dependencies between structure and geometry and encoding two augmented features, which are then fused into a single latent code. This explicit intertwining of information enables separately controlling the geometry and the structure of the generated models. We evaluate the performance of our method and conduct an ablation study. We explicitly show that encoding of shapes accounts for both similarities in structure and geometry. A variety of quality results generated by SAGNet are presented. The data and code are at https://github.com/zhijieW-94/SAGNet.
Figure S4 from Treatment of Prostate Cancer with CD46-targeted &lt;sup&gt;225&lt;/sup&gt;Ac Alpha Particle Radioimmunotherapy (2023)

&lt;p&gt;Figure S4: Gamma energy spectra of the tumor, blood, kidneys, and bone showing the intensities of the 213Bi and 221Fr peaks. As compared to the equilibrium gamma energy spectra of [225Ac]DOTA-YS5, increased intensity of the 213Bi was observed in kidney samples.&lt;/p&gt;
Enhancement of 1.54-μm emission from Er-doped sol-gel SiO2 films by Au nanoparticles doping (2005)

A 1.54-μm emission from erbium-doped sol-gel SiO2 was strongly enhanced by doping Au nanoparticles. The enhancement factor depended on Au concentration and was the largest at the concentration of 1.0mol%. The photoluminescence enhancement was accompanied by the lengthening of the lifetime, suggesting that the enhancement is caused by the decrease of hydroxyl groups. In addition, enhancement due to strong fields induced by localized surface plasmon of Au nanoparticles was observed.
KINETIC STUDIES OF HYDROLYSIS REACTION OF NaBH4 WITH γ-Al2O3 NANOPARTICLES AS CATALYST PROMOTER AND CoCl2 AS CATALYST (2019)

Solid-state hydrogen storage is of considerable concern as a potential hydrogen source for portable fuel cell applications. This study mainly focuses on kinetics of NaBH4/Al2O3 nanoparticles (20 nm)/H2O system with CoCl2 as catalyst and the factors that affect the hydrogen generation rate (HGR). It is observed that the reaction rate increases considerably with increase in NaBH4, Al2O3 nanoparticle (20 nm), CoCl2 and NaOH concentrations and the respective reaction orders are calculated. Hydrogen generation rate is also investigated at different temperatures (303, 313, 323 and 333 K) for constant NaBH4 (1.25 moles/L), NaOH (1.4 moles/L), CoCl2 (0.02 moles/L) and Al2O3 (0.09 moles/L) concentrations. Kinetics of the NaBH4 hydrolysis reaction increases with γ-Al2O3 nanoparticles and the calculated activation energy is 29 kJ/moles. This study also reports that a combined dual-solid-fuel system is highly efficient in terms of hydrogen storage capacities compared with a single hydride based system. Maximum hydrogen generation efficiency, observed at a mass ratio of 0.09: 0.7 (Al2O3/NaBH4), is 99.34%.
Heizungstechniken im Thermoformen (2016)

No AccessThermoformen in der PraxisMay 2016Heizungstechniken im ThermoformenIllig, Peter SchwarzmannIlligSearch for more papers by this author, Peter SchwarzmannSearch for more papers by this authorhttps://doi.org/10.3139/9783446449480.004SectionsAboutPDF ToolsAdd to FavoritesDownload CitationTrack CitationsCopy LTI LinkPDF key 'share (en)' returned an object instead of string.FacebookTwitterEmailLinkedIn previous chapternext chapter FiguresReferencesRelatedDetails 2016Pages: 129-157Print ISBN: 978-3-446-44403-4eISBN: 978-3-446-44948-0 Copyright & Permissions© 2016 Carl Hanser Verlag GmbH & Co. KGPDF DownloadLoading ...
Abstract LB-303: Berubicin, a brain tumor targeting anthracycline: Discovery and clinical evaluation (2008)

Abstract Development of effective chemotherapeutic strategies to treat brain tumors has been limited in part by the inaccessibility of the CNS to pharmacological intervention. Topoisomerase II (topo II) overexpression has been well documented in human gliomas and is correlated to poor survival, but to date no effective topo II poison, capable of reaching the target tissue after systemic administration, has been developed. We hypothesized that the presence of ATP-binding cassette (ABC) transporters in the blood-brain barrier (BBB) might, in part, be responsible for limiting the CNS penetration of most anticancer drugs including topo II poisons like doxorubicin (DOX). To identify new agents effective in vivo against brain tumors, we have used our innovative modular design of DNA-binding agents to create unique libraries of potential topo II poisons. By systematically screening such libraries, we have identified highly apoptotic compounds that can circumvent P-gp and MRP1-mediated resistance mechanisms, suggesting that such compounds will be potent cytotoxins against gliomas, through their ability to cross the BBB.Synthesis and in vitro screening of a library of over 400 DNA binding agents in a panel of cells overexpressing P-gp and MRP1 led to identification of 10 compounds possessing the necessary characteristics from which the compound Berubicin (RTA744, WP744) was selected for detailed preclinical evaluation. Berubicin (BRB) is structurally related to the well-known anticancer drug DOX, but is significantly more apoptotic than DOX against multidrug-resistant tumor cell lines with the MDR1 and MRP1 phenotypes and can cross the BBB, achieving CNS and brain tumor concentrations exceeding that of plasma. Subsequent preclinical development led to IND and Phase I clinical studies in humans. In the first Phase I trial dose escalation of BRB proceeded according to an accelerated titration design, with single patient cohorts and 100% dose escalations until evidence of drug-related Grade 2 or greater toxicities were observed. The MTD of berubicin administered on a qd X 3 schedule was 7.5 mg/m2/day (22.5 mg/m2/cycle). Toxicities appear consistent with the anthracycline class, with no unexpected toxicities observed. Of interest no neurotoxicity or cardiotoxicity have been reported. Median time to progression in the Phase I study as of 5/21/ 2007 was 7.4 weeks with one complete response (CR), one partial response (PR)) and 7 minor response or stable disease patients, observed. Because of the unique biological characteristics of BRB (potent topo II poison, ability to cross BBB, activity against multidrug resistant tumors) and the results of Phase I clinical studies this agent is uniquely placed to become an effective therapeutic agent for the treatment of brain tumors.
CONSTRAINTS ON AN INDUCTIVE SENSOR FOR AN INTRAOCULAR LENS (2014)

status: Accepted
Score-based diffusion models for accelerated MRI (2021)

Score-based diffusion models provide a powerful way to model images using the gradient of the data distribution. Leveraging the learned score function as a prior, here we introduce a way to sample data from a conditional distribution given the measurements, such that the model can be readily used for solving inverse problems in imaging, especially for accelerated MRI. In short, we train a continuous time-dependent score function with denoising score matching. Then, at the inference stage, we iterate between numerical SDE solver and data consistency projection step to achieve reconstruction. Our model requires magnitude images only for training, and yet is able to reconstruct complex-valued data, and even extends to parallel imaging. The proposed method is agnostic to sub-sampling patterns, and can be used with any sampling schemes. Also, due to its generative nature, our approach can quantify uncertainty, which is not possible with standard regression settings. On top of all the advantages, our method also has very strong performance, even beating the models trained with full supervision. With extensive experiments, we verify the superiority of our method in terms of quality and practicality.
Right bundle branch block in patients with suspected myocardial infarction (2018)

Our results support the new European Society of Cardiology ST-segment elevation myocardial infarction guideline describing RBBB as a high risk for mortality in patients with suspected myocardial infarction. However, the data challenge the concept of RBBB as a trigger of acute angiography because the likelihood of myocardial infarction in a chest pain unit setting is equally frequent in patients without bundle branch block.
Engineering a branch of the UDP‐precursor biosynthesis pathway enhances the production of capsular polysaccharide in <i>Escherichia coli</i> O5:K4:H4 (2015)

Abstract Escherichia coli K4 produces a capsule with a chemical structure that resembles chondroitin, a molecule with established chondro protective properties. The endogenous genes pgm and galU are involved in the biosynthesis of UDP‐glucose which is a critical intermediate in carbohydrate metabolism and biochemical precursor of UDP‐glucuronic acid. Together with UDP‐ N ‐acetylgalactosamine, UDP‐glucuronic acid is used as sugar donor for capsule biosynthesis. The aim of the study was to evaluate how a change in the pathways leading to UDP‐glucuronic acid biosynthesis affected capsular polysaccharide production. One additional copy of pgm and galU was introduced in E. coli K4 and in the previously described recombinant strain EcK4r3. A microbioreactor was used to analyse strain performance with parallel batch experiments, demonstrating increased polysaccharide concentrations and providing data that are comparable to those obtained in larger fermenters. Further experiments on a glutamine enriched medium showed an additional 45% increase of capsule production, maybe indicating the need to balance both branches leading to polymer biosynthesis in order to maximize yields. In the effort towards the establishment of a feasible bio‐chondroitin production process this study provides information on how the availability of sugar precursors impacts polysaccharide biosynthesis in E. coli K4, a complex unexplored aspect of a multifaceted process.
Acoustic scatter from a submerged target in a waveguide (2005)

In very shallow water or bounded acoustic medium (waveguide), the acoustic scattering from a target located in the waveguide is influenced by the presence of the boundaries. This is due to the multiple reflections occurring between the target and the waveguide boundaries. In this paper, the influence of boundaries on the acoustic scattering from a rigid sphere is investigated. A superposition method with equivalent point sources located inside the surface of the target and calibrated by satisfying the boundary conditions on the surface of the target is used to model the problem. The target is insonified by an equivalent plane acoustic wave traveling parallel to the waveguide boundaries. The presence of the boundaries breaks the symmetry in the scattering patterns and influences the scattering strength of the target. At particular frequencies or scatterer depths, a significant change in the magnitude and spatial distribution of the scattered field occur due to strong coupling between the target and the boundary. It is concluded that the scattering in VSW can be significantly different from that of the same target in an unbounded medium.
Modifying Graphene Substrates for Imaging Proteins in a Transmission Electron Microscope (2014)

Journal Article Modifying Graphene Substrates for Imaging Proteins in a Transmission Electron Microscope Get access Christopher J Russo, Christopher J Russo Medical Research Council Laboratory of Molecular Biology, Cambridge United Kingdom Search for other works by this author on: Oxford Academic Google Scholar Lori A Passmore Lori A Passmore Medical Research Council Laboratory of Molecular Biology, Cambridge United Kingdom Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 20, Issue S3, 1 August 2014, Pages 1214–1215, https://doi.org/10.1017/S1431927614007806 Published: 27 August 2014
Abstract 17366: Intraoperative Ventricular Tachycardia Ablation During Left Ventricular Assist Device Implant in Patients With Medically Refractory Ventricular Tachycardia (2016)

Introduction: Patients with advanced heart failure proceeding to LVAD implant require a multidisciplinary approach to their care. These patients often require multimodal therapies for control of th...
Fast Determination of Vehicle Suspension Parameters via Continuous Time System Identification * *This work has been supported by the Linz Center of Mechatronics (LCM) in the framework of the Austrian COMET-K2 program. (2016)

Having accurate estimates for the parameter values of different vehicle components is crucial when it comes to the level of virtual testing of vehicle dynamics. Since these values are often not directly available, they need to be obtained from measurements. The most straightforward, but also most expensive way to obtain unknown values is by disassembling the car and by performing tests on the separate vehicle components. A solution that is often much cheaper is to infer estimates of the parameter values from measurements obtained by performing different driving maneuvers with the car. In this paper we show how methods from direct continuous time system identification (CT SysId) can be used to obtain accurate estimates for parameter values of the vehicle suspension system. The dynamic tests consist in exciting the suspension system by driving over one or several small obstacles and by recording the dynamic response of the car. CT Sysld is used to adapt the unknown parameter values of a tentative car model in order to best match the measured data. Evaluation of the approach using a multi-body simulation tool showed that the identified parameter values match well with the ones of the simulated vehicle suspension system.
Effect of dispersant on nano-PTFE based lubricants on tribo-performance in fretting wear mode (2016)

This work describes the anti-friction (AF) and anti-wear (AW) effects of nano-PTFE-PIBSI (polyisobutylene succinimide) additive interactions in a lubricant system.
Effect of an optical coating on in-band and out-of-band transmitted and reflected wavefront error measurements (2020)

The wavefront error (WE) of a surface with an optical coating ("filter") is ideally measured at the in-band wavelength of the filter. However, quite often this is not possible, requiring that the filter be measured at an out-of-band wavelength (typically 633 nm), assuming that the filter transmits (for transmitted WE, or TWE) or reflects (for reflected WE, or RWE) at this wavelength. This out-of-band TWE/RWE is generally assumed to provide a good estimation of the desired in-band TWE/RWE. It will be shown in this paper that this is not the case for a large class of filters (i.e., bandpass) where the group delay is significantly different at the in-band and out-of-band wavelengths and where the optical filter exhibits a thickness non-uniformity across the surface. A theoretical explanation will be given along with an approach to predict the in-band TWE/RWE based on the coating non-uniformity, the measured out-of-band TWE/RWE, and the theoretical properties of the optical filter at the in-band and out-of-band wavelengths. A reasonable agreement between theory and measurement was demonstrated by measuring the TWE of an 11 nm wide bandpass filter (centered at 1048 nm) at both in-band (<i>λ</i>=1048<i>n</i><i>m</i>) and out-of-band (<i>λ</i>=625<i>n</i><i>m</i>) wavelengths. A similar treatment is provided for RWE.
Controlling the canonical/zwitterionic balance through intramolecular proton transfer: a strategy for vapochromism (2018)

<italic>N</italic>-Substituted diamino-benzoquinone diimines featuring tunable aryl electron-withdrawing functions and vapochromic properties have been developed.