gebhart/patrepeval huggingface dataset:
Short-term reliability of high performance Q-band AlN/GaN HEMTs (2020)

We report on an on-wafer short-term 40 GHz RF reliability stress test comparison up to 140°C base plate temperature between a 3 nm and 4 nm barrier thickness AlN/GaN HEMT technology showing high power performances in the millimeter wave range. It is found that the barrier thickness in this highly strain heterostructure has a major impact on the device reliability. The superior robustness when using thinner barrier (closer to the critical thickness) is attributed to the reduced strain.
Positional Candidate Gene Approach and Functional Genomics Strategy in Atopy Gene Discovery (1999)

As part of our effort in searching for genetic factors contributing to the susceptibility to atopy and asthma, we have focused on a 'positional candidate' approach in identifying CC chemokine gene polymorphisms and their functional correlates. To date, a single-nucleotide polymorphism was found in the RANTES proximal promoter region, and a high degree of sequence variation was identified in the 3'-untranslated region -of the eotaxin gene. Also, we are pursuing a series of functional genomics' studies designed to identify differentially expressed genes in a panel of allergen-specific human Th2 cells and in antigen-induced hyperreactive murine airways. This is performed using a combination of protocols including suppression-subtractive hybridization and cDNA array hybridizations with 18,363 nonredundant sequences. A data base is being generated from a list of subtracted cDNA sequences and array-positive clones to categorize differentially expressed genes. Sequences are being placed in biologically relevant categories on the basis of function (i.e., receptor, signal transduction pathways, transcription, and translation). With the increasing amount of sequence information compiled by the Human Genome Project, it will be particularly challenging to integrate functional gene-mapping efforts to define and compare aberrant genotypes/phenotypes in atopic diseases.
Information and communication technology used by people with lower limb loss in Slovenia (2020)

World demography is changing as the population ages and there are more people with disabilities having problems to stay independently at home. Innovative technologies could help extend the independence of older people living at home. As part of a collaborative project, we investigated ownership and use of information and communication technologies (ICT) among older people with lower limb loss (LLL) using questionnaires and retrospective analysis. Our aim was to analyse factors associated with ICT use among people with LLL. We identified age as the main factor that limits ownership and use of ICT among older people with LLL in Slovenia. Cause of amputation also appears to be relevant, whereby those who had amputation because of peripheral vascular disease are more likely to use a personal or tablet computer, social networks, messaging apps, email and internet than those who had amputation because of diabetes. In addition, those living in the suburbs are more likely to use a health monitoring device than those living in the countryside.
Design and Synthesis of 4‐Substituted‐8‐(2‐phenyl‐cyclohexyl)‐2,8‐diaza‐spiro[4,5]decan‐1‐one as a Novel Class of GlyT1 Inhibitors: Achieving Selectivity Against the μ Opioid and Nociceptin/Orphanin FQ Peptide (NOP) Receptors. (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Supplementary Figure Legends 1-6, Methods, Table 2 legend from Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia (2023)

Supplementary Figure Legends 1-6, Methods, Table 2 legend from Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia
Coupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma (2020)

A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell renal cell carcinoma (ccRCC) stages I, II, III, and IV (<i>n</i> = 112) and controls (<i>n</i> = 52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spectrometry and machine learning techniques. Multivariate models based on support vector machines and the LASSO variable selection method yielded two discriminant lipid panels for ccRCC detection and early diagnosis. A 16-lipid panel allowed discriminating ccRCC patients from controls with 95.7% accuracy in a training set under cross-validation and 77.1% accuracy in an independent test set. A second model trained to discriminate early (I and II) from late (III and IV) stage ccRCC yielded a panel of 26 compounds that classified stage I patients from an independent test set with 82.1% accuracy. Thirteen species, including cholic acid, undecylenic acid, lauric acid, LPC(16:0/0:0), and PC(18:2/18:2), identified with level 1 exhibited significantly lower levels in samples from ccRCC patients compared to controls. Moreover, 3α-hydroxy-5α-androstan-17-one 3-sulfate, <i>cis</i>-5-dodecenoic acid, arachidonic acid, <i>cis</i>-13-docosenoic acid, PI(16:0/18:1), PC(16:0/18:2), and PC(O-16:0/20:4) contributed to discriminate early from late ccRCC stage patients. The results are auspicious for early ccRCC diagnosis after validation of the panels in larger and different cohorts.
p75 Neurotrophin Receptor Mediates Neuronal Cell Death by Activating GIRK Channels through Phosphatidylinositol 4,5-Bisphosphate (2008)

The pan neurotrophin receptor p75(NTR) signals programmed cell death both during nervous system development and after neural trauma and disease in the adult. However, the molecular pathways by which death is mediated remain poorly understood. Here, we show that this cell death is initiated by activation of G-protein-coupled inwardly rectifying potassium (GIRK/Kir3) channels and a consequent potassium efflux. Death signals stimulated by neurotrophin-mediated cleavage of p75(NTR) activate GIRK channels through the generation and binding of phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2/PIP2] to GIRK channels. Both GIRK channel activity and p75(NTR)-mediated neuronal death are inhibited by sequestration of PtdIns(4,5)P2 and application of GIRK channel inhibitors, whereas pertussis toxin treatment has no effect. Thus, p75(NTR) activates GIRK channels without the need for G(i/o)-proteins. Our results demonstrate a novel mode of activation of GIRK channels, representing an early step in the p75(NTR)-mediated cell death pathway and suggesting a function for these channels during nervous system development.
Calcium Channel Modulation of α1- and α2-Adrenergic Pressor Responses in Conscious and Anesthetized Dogs (1990)

The influence of halothane and isoflurane on alpha-adrenergic-mediated vasoconstriction before and following calcium channel modulation was investigated in chronically instrumented dogs. After ganglionic, cholinergic, and beta-adrenergic blockade, systemic hemodynamic responses following equieffective pressor doses of phenylephrine (0.6 micrograms/kg iv), a selective alpha 1 agonist, and azepexole [B-HT 933] (20 micrograms/kg iv), a selective alpha 2 agonist, were obtained. The calcium channel stimulator Bay k 8644 (0.5 and 1 micrograms.kg-1.min-1) was infused intravenously for 10 min and phenylephrine and azepexole administered at the end of each infusion. On different days, each dog was subsequently anesthetized with equihypotensive concentrations of halothane (1.7%) or isoflurane (2%) in oxygen and the same pharmacologic interventions were repeated in the presence of halothane or isoflurane. Twenty-one experiments (three groups) using seven chronically instrumented dogs were completed. Halothane and isoflurane produced significant (P less than 0.05) attenuation of the increase in arterial pressure after bolus administration of phenylephrine and azepexole. Bay k 8644 augmented the pressor responses mediated by both phenylephrine and azepexole in all three groups. Thus, halothane and isoflurane nonselectively reduced the pressor response to both alpha 1- and alpha 2-adrenergic receptor stimulation and this was probably not mediated by inhibition of transmembrane calcium flux through dihydropyridine sensitive channels.
Smart Closet: Statistical-based apparel recommendation system (2014)

Managing closet has long been a problem especially in today's world where people are always in hurry and most of the time, end up choosing to wear the same dressing styles or the same piece of clothes. In addition, we also notice that people tend to stick with one or two dressing style and buy new clothes that are very similar to the ones they already have. This usually results in a huge waste of time and money. Our team sees such the problems and proposes to develop the Smart Closet Application to help people efficiently manage their closet, easily keep track the clothes in the closet, and effectively utilize their closet inventories. Smart Closet Application allows you to store your closet directly in your smart phone. User can add his/her own clothes and accessories into the Smart Closet system. By using this application, user can mix and match his/her personal clothes, and accessories from head to toes. The unique feature of the Smart closet application is that it can keep statistics of clothes and accessories that are frequently used and suggest the dressing style based on what is learned from the past statistics. Furthermore, this application can give suggestion on appropriate dressing styles for current weather condition and special occasions.
Range Imaging for Motion Compensation in C-Arm Cone-Beam CT of Knees under Weight-Bearing Conditions (2018)

C-arm cone-beam computed tomography (CBCT) has been used recently to acquire images of the human knee joint under weight-bearing conditions to assess knee joint health under load. However, involuntary patient motion during image acquisition leads to severe motion artifacts in the subsequent reconstructions. The state-of-the-art uses fiducial markers placed on the patient’s knee to compensate for the induced motion artifacts. The placement of markers is time consuming, tedious, and requires user experience, to guarantee reliable motion estimates. To overcome these drawbacks, we recently investigated whether range imaging would allow to track, estimate, and compensate for patient motion using a range camera. We argue that the dense surface information observed by the camera could reveal more information than only a few surface points of the marker-based method. However, the integration of range-imaging with CBCT involves flexibility, such as where to position the camera and what algorithm to align the data with. In this work, three dimensional rigid body motion is estimated for synthetic data acquired with two different range camera trajectories: a static position on the ground and a dynamic position on the C-arm. Motion estimation is evaluated using two different types of point cloud registration algorithms: a pair wise Iterative Closest Point algorithm as well as a probabilistic group wise method. We compare the reconstruction results and the estimated motion signals with the ground truth and the current reference standard, a marker-based approach. To this end, we qualitatively and quantitatively assess image quality. The latter is evaluated using the Structural Similarity (SSIM). We achieved results comparable to the marker-based approach, which highlights the potential of both point set registration methods, for accurately recovering patient motion. The SSIM improved from 0.94 to 0.99 and 0.97 using the static and the dynamic camera trajectory, respectively. Accurate recovery of patient motion resulted in remarkable reduction in motion artifacts in the CBCT reconstructions, which is promising for future work with real data.
Synthesis and Structure of [NbCl3(NPPh2Fc)2]: The First Example of a Complex Containing a Redox-functionalised Phosphaneiminato Ligand (1999)

Reaction of Me3SiNPPh2Fc (Fc = ferrocenyl) with niobium pentachloride affords [NbCl3(NPPh2Fc)2], whose redox-functionalised phosphaneiminato ligands exhibit remarkably different bend angles at nitrogen according to a crystal structure analysis.
Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice (2011)

Our findings suggest that, contrary to suggestions from previous studies with (imperfectly selective) pharmacological agents having T-type Ca(2+)-channel-blocking actions, elimination of Cav3.1 expression leads to impaired cardiac function and enhanced arrhythmia vulnerability post-MI, whereas Cav3.2 elimination has no effect.
Frequency scalable large signal transistor behavioral model based on admittance domain formulation (2014)

This paper introduces the first formulation and approach that enables measurement based non-linear behavioral look-up table transistor models to be frequency scalable. The experimental results on a M/A-COM GaN HFET from 2 GHz to 8 GHz, support theoretical analysis that frequency domain behavioral models defined in the admittance domain have frequency scalable model coefficients. Load-pull results indicate that the model can accurately predict non-linear behavior at frequencies where the large signal measurements were not performed.
Key Extraction From General Nondiscrete Signals (2009)

We address the problem of designing optimal schemes for the generation of secure crypto-\ngraphic keys from continuous noisy data. We argue that, contrary to the discrete case, a\nuniversal fuzzy extractor does not exist. This implies that in the continuous case, key ex-\ntraction schemes have to be designed for particular probability distributions. We extend the\nknown definitions of the correctness and security properties of fuzzy extractors. Our defini-\ntions apply to continuous as well as discrete variables.\nWe propose a generic construction for fuzzy extractors from noisy continuous sources, using independent partitions. The extra freedom in the choice of discretisation, which does not exist in the discrete case, is advantageously used to give the extracted key a uniform distribution. We analyze the privacy properties of the scheme and the error probabilities in a one-dimensional toy model with simplified noise.\nFinally, we study the security implications of incomplete knowledge of the source's probability distribution P. We derive a bound on the min-entropy of the extracted key under the worst case assumption, where the attacker knows P exactly.
Reduced-dose Radiosurgery for Vestibular Schwannomas (2001)

Low-dose radiosurgery in this series provided comparable local control and decreased incidences of complications in relation to other reports. Additional follow-up will allow more definitive conclusions to be reached regarding the ultimate rates of tumor control and hearing preservation. Nevertheless, the current dose used for vestibular schwannomas at the University of Maryland Medical Center is 12.0 Gy to the tumor periphery.
Deprescribing statins, considerations for informed decision making (2023)

The authors declare no conflicts of interest.
60-Gb/s Mode Division Multiplexing and Wavelength Division Multiplexing in Si Multimode Waveguides (2013)

A silicon photonic waveguide system with mode-division and wavelength-division-multiplexing capabilities is demonstrated. Error-free (BER < 10-12) data transmission of 2 modal channels and 3wavelengths operating with aggregate bandwidth of 60-Gb/s is realized. This work motivates future bandwidth scalability of silicon photonic interconnects.
A Kalman filter algorithm for estimating sinusoids in colored noise (2005)

When the input to the adaptive line enhancer (ALE) contains colored noise, it is shown that implementations of adaptive line enhancers using recursive least squares (RLS) algorithms result in suboptimal estimates of the least squares weight vector. Looking at RLS filtering as a Kalman filtering problem makes it possible to account for the presence of colored observation noise by implementing a model of the colored noise using an augmented state equation. The RLS filter derived from this augmented state equation and the corresponding augmented observation equation is shown to have improved performance over the standard RLS filter for ALE prediction lengths greater than and significantly less than the decorrelation time of the colored observation noise.
Visceral Obesity without Insulin Resistance in Late-Onset Obesity Rats (2004)

We describe a line of transgenic rats in which the males develop a unique autosomal dominant, late-onset obesity (LOB) phenotype. LOB males gradually accumulate fat specifically in visceral, but not peripheral, fat depots despite a normal intake of a low fat diet. LOB females normally develop only mild obesity with advanced age. However, the phenotype can be induced rapidly in young females by ovariectomy and prevented by estrogen replacement. LOB males are highly sensitive to dietary fat. Young, nonobese LOB males gain more weight on a 30% fat diet and lose more weight when treated with the lipase inhibitor, Orlistat, than their nontransgenic littermates. Remarkably, despite severe visceral obesity, LOB rats have normal fasting blood glucose, insulin, and corticosterone; show normal or increased insulin sensitivity in glucose and insulin tolerance tests; have increased plasma adiponectin levels; and display a heightened response to treatment with rosiglitazone. Their visceral adiposity reflects a specific increase in visceral adipocyte number, not size. Analysis of the transgene in LOB rats revealed a deletion in the gene encoding the S26 subunit of the mitochondrial ribosome that results in the production of a truncated protein, which we show to be imported into mitochondria. However, the transgene integrant is complex, so whether this is the sole molecular disruption underlying this phenotype remains to be established. Nevertheless, LOB rats provide a valuable new model of late-onset, male-preponderant, visceral-specific obesity, clearly dissociated from insulin resistance.
Measurement of the spin-orbit coupling interaction in ring-core optical fibers (2019)

Ring-core optical fibers have been designed to carry orbital angular momentum modes. We demonstrate the imaging of these modes, individually identifying modes separated temporally by only 30 ps. A single-pixel camera operating in the short-wave infrared detection range is used to image the 1550 nm wavelength optical modes. With this technique, examination of these optical modes can be performed with significantly higher temporal resolution than is possible with conventional imaging systems, such that the imaging of modes separated by spin-orbit coupling is achieved and evaluated. Deconvolution is required to separate the instrument response from the optical mode signal, increasing the clarity and temporal resolution of the measurement system.
Reactions of an Arylrhodium Complex with Aldehydes, Imines, Ketones, and Alkynones. New Classes of Insertion Reactions (2004)

Organorhodium complexes of the general formula (DPPE)Rh(pyridine)(R) (R = p-tol (2a) and CH2SiMe3 (2b), DPPE = 1,2-bis(diphenylphosphino)ethane) were prepared from [(DPPE)Rh(μ-Cl)]2, pyridine, and p-tolyllithium or Me3SiCH2MgCl. Complex 2a inserted the electron-poor aldimines (p-tol)CHN(C6H4-p-CO2Me) (3a-Tol) and (Ph)CHN(C6H4-p-CO2Me) (3a-Ph) to give amide complexes that were isolated directly or trapped with PEt3. In contrast, the reaction of aryl complex 2a with the electron-neutral and electron-rich imines PhCHNPh (3b) and (p-tol)CHN(C6H4-p-OMe) (3c) did not form stable amide products. Instead, the amide from insertion of imines 3b or 3c underwent β-hydrogen elimination, followed by metalation of the resulting ketimine. The reaction of 2a with 3a-Ph was first order in arylrhodium complex and inverse first order in the concentration of pyridine. Aldehydes that cannot enolize, such as PhCHO and Me3CCHO, inserted into the Rh−aryl bond of 2a to form ketones and esters. The esters were formed from insertion of a second aldehyde into the Rh−O bond of an intermediate alkoxide, followed by β-hydride elimination. Complex 2a underwent proton transfer with acetophenone to give π-oxaallyl complex 24 and with water to generate toluene and the dimeric hydroxide [(DPPE)Rh(μ-OH)]2 (36). It also reacted with the tert-butyl-substituted ynone 25 to form a product that contained a metalated isobutyl group. Quenching the reaction between aryl complexes 2a and 3a-Ph with H2O instead of PEt3 also formed hydroxide 36 and the diarylmethylamine (Ph)(p-tol)CH−NH(C6H4-p-CO2Me) (35).
Shared Dorsal Periaqueductal Gray Activation Patterns during Exposure to Innate and Conditioned Threats (2021)

The brainstem dorsal periaqueductal gray (dPAG) has been widely recognized as being a vital node orchestrating the responses to innate threats. Intriguingly, recent evidence also shows that the dPAG mediates defensive responses to fear conditioned contexts. However, it is unknown whether the dPAG displays independent or shared patterns of activation during exposure to innate and conditioned threats. It is also unclear how dPAG ensembles encode and predict diverse defensive behaviors. To address this question, we used miniaturized microscopes to obtain recordings of the same dPAG ensembles during exposure to a live predator and a fear conditioned context in male mice. dPAG ensembles encoded not only distance to threat, but also relevant features, such as predator speed and angular offset between mouse and threat. Furthermore, dPAG cells accurately encoded numerous defensive behaviors, including freezing, stretch-attend postures, and escape. Encoding of behaviors and of distance to threat occurred independently in dPAG cells. dPAG cells also displayed a shared representation to encode these behaviors and distance to threat across innate and conditioned threats. Last, we also show that escape could be predicted by dPAG activity several seconds in advance. Thus, dPAG activity dynamically tracks key kinematic and behavioral variables during exposure to threats, and exhibits similar patterns of activation during defensive behaviors elicited by innate or conditioned threats. These data indicate that a common pathway may be recruited by the dPAG during exposure to a wide variety of threat modalities.<b>SIGNIFICANCE STATEMENT</b> The dorsal periaqueductal gray (dPAG) is critical to generate defensive behaviors during encounters with threats of multiple modalities. Here we use longitudinal calcium transient recordings of dPAG ensembles in freely moving mice to show that this region uses shared patterns of activity to represent distance to an innate threat (a live predator) and a conditioned threat (a shock grid). We also show that dPAG neural activity can predict diverse defensive behaviors. These data indicate the dPAG uses conserved population-level activity patterns to encode and coordinate defensive behaviors during exposure to both innate and conditioned threats.
Tattoo Darkening and Nonresponse After Laser Treatment (2001)

Titanium is overrepresented in tattoos that respond poorly to laser treatment. Further studies are necessary to show whether this metal is the primary cause of this poor response.
First Intramolecular Alkylation of Nitriles with Primary and Secondary Alcohols Catalyzed by Iridium Complexes (2012)

Abstract The first iridium‐catalyzed intramolecular alkylation ofnitriles with primary and secondary alcohols through hydrogen transfer is described. This reaction allows access to precursors of biologically active arylmethylamines.
[Fatty fish modifies HDL particle size and lipid concentrations]. (2013)

Frequent intake of fatty fish may have beneficial effects on HDL-metabolism beyond that assumed to be related to its serum concentrations.