gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis of Casein‐Related Peptides and Phosphopeptides. Part 9. A Modified Method for the Synthesis of Ser(P) Peptides by Using Ppoc‐Ser( PO3Bzl2)‐OH. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Complement Activation and Resistance within the Cerebrospinal Fluid Following Intraventricular Administration of Anti-CD20 in the Treatment of Recurrent CNS Lymphoma. (2007)

Abstract We recently conducted the first phase I dose escalation study of intraventricular rituximab (anti-CD20 antibody) in patients with recurrent central nervous system (CNS) non-Hodgkin’s lymphoma (NHL). The goals of this study have been to define the safety and pharmacokinetics of intraventricular rituximab monotherapy and to gain insight into the molecular basis of rituximab efficacy and resistance in the treatment of high-grade lymphomas. We observed a rapid lymphocytotoxic effect of intraventricular rituximab administration in six out of ten subjects treated, resulting in four complete responses at the completion of five weeks of therapy. Cytologic responses were evident within one hour of rituximab treatment and were not likely related to the action of corticosteroids as these were held stable, tapered or withheld in the week before intrathecal therapy. Three potential mechanisms have been proposed to explain the basis for rituximab efficacy in the treatment of NHL: direct induction of apoptosis; complement-dependent cytotoxicity (CDC); antibody dependent cellular cytotoxicity (ADCC). Given the rapid rate of response detected in the leptomeningeal compartment and the relative paucity of Fc-receptor bearing natural killer cells detected in the CSF, we tested the hypothesis that complement activation is responsible for the rapid rituximab-mediated tumor cell lysis which we observed. Pretreatment gene expression profile analysis of meningeal lymphoma cells isolated from CSF demonstrated that RNA levels of expression of CD46, CD55, and CD59 were similar in both responding and non-responding patients. However microarray analysis suggested a possible correlation between low levels of complement receptor 2 (CD21) and immediate rituximab resistance. We focused on the potential generation of C3a anaphylatoxin in the CSF after rituximab administration as C3 is the central component in the classical and alternative complement pathways. Quantitative measurement of C3a concentration in CSF by ELISA demonstrated rapid activation of the complement cascade within one hour of intrathecal anti-CD20 antibody administration. C3a concentrations increased between three-to-eight-fold up to peak concentrations greater than 300 ng/ml. These findings were confirmed by immunoblot analysis of C3a in CSF. Acquired rituximab resistance was associated with marked decreases in the magnitude of complement activation in two patients who initially had exhibited complete responses to intraventricular rituximab monotherapy. These results suggest a mechanistic basis for the rapid lymphocytoxic effects observed and provide a possible explanation for the development of acquired rituximab resistance.
Operating in the green: Modeling eco-friendly telecom network management (2010)

Service providers systematically evaluate the complete cost of owning and operating a network to determine the financial impact of technology on their bottom line. As companies begin to address today's environmental challenges, this adds a new dimension of environmental responsibility to the list of decision making criteria the service provider must consider. A comprehensive decision making tool that encompasses both monetary cost and ecological impact will enable the service provider to make fiscally and environmentally sound choices. In this paper, the authors consider the environmental impact of network operations using an approach similar to one typically used to evaluate cost. The full breadth of network operations is considered, including the technology, processes, and organization required to run a network. A module that can be used to calculate the carbon footprint associated with operating a network is proposed and described in parametric terms. The interdependencies of operational choices and techniques for reducing the environmental impact of operations are also discussed.
Net-centric information and knowledge management and dissemination for data-to-decision C2 applications using intelligent agents and service-oriented architectures (2011)

The Tactical Information Technologies for Assured Network Operations (TITAN) Program aims to achieve net-centric information and knowledge management and dissemination integrated with data-to-decision C2 Applications. TITAN is a multi-year effort to develop, demonstrate and mature information and knowledge (I&K) management and dissemination (M&D) services spanning multiple echelons and provide support to the network-centric operations process with collaborative military planning and execution monitoring. TITAN integrates heterogeneous, open-source intelligent agents and web services with network-centric communications infrastructures. These agents and services are designed to support users executing the Operations Process for command and control across command echelons from units on the upper tactical internet at brigade and above to units on the lower tactical internet at battalion and below. The result is an adaptive system for collaborative battle command planning, execution and monitoring. In delivering TITAN, the team had to engineer novel solutions to several current research problems. These technical contributions include the development of a Battle Command-Warfighter (BCW) interface that integrates planning with situation awareness; definition of interoperability schemas for C2 information sources and services; management of distributed provenance; implementation of a network-centric message bus for communications across different network echelons and radios; and the development of agents and services to support Mission Command planning processes and numerous Data-to-Decision (D2D) threads in a comprehensive manner to execute TRADOC's Multi-Level Scenario. The integrated TITAN system has been demonstrated in numerous settings and was featured at the Ft. Dix C4ISR “On the Move” experiment in summer 2011.
Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning (2019)

This study provides a valuable drug repositioning accompanied by corresponding targetable gene clusters for FSS therapy.
Integrating Host Genomics with Surveillance for Invasive Bacterial Diseases<i/> (2008)

We tested the feasibility of linking Active Bacterial Core surveillance, a prospective, population-based surveillance system for invasive bacterial disease, to a newborn dried blood spot (nDBS) repository. Using nDBS specimens, we resequenced CD46, putative host gene receptor for Neisseria meningitidis, and identified variants associated with susceptibility to this disease.
RUNX1-ETO induction rapidly alters chromatin landscape and growth of a specific sub-population of hESC-derived myeloid precursor cells by interfering with RUNX1 regulation (2019)

Summary Acute myeloid leukemia is a hematopoietic malignancy caused by recurrent mutations in genes encoding transcriptional, epigenetic and/or signaling regulators. The t(8;21) translocation generates the aberrant transcription factor RUNX1-ETO whose expression can be detected in utero but is insufficient to cause overt disease. Although patients harboring cells with the t(8;21) translocation have acquired additional mutations and show extensive epigenetic reprogramming, the effects directly attributable to RUNX1-ETO expression are unclear. To address this question, we used a human embryonic stem cell differentiation system capable of forming definitive human myeloid progenitor cells to express RUNX1-ETO in an inducible fashion. Induction of RUNX1-ETO causes extensive chromatin reprogramming by interfering with RUNX1 binding, blocks differentiation and arrests cellular growth, whereby growth arrest is reversible following RUNX1-ETO removal. Single cell gene expression analyses show that RUNX1-ETO induction alters the differentiation of a defined sub-population of progenitors, indicating that oncoprotein-mediated transcriptional reprogramming is highly target cell specific.
Optoacoustic model-based inversion using anisotropic adaptive total-variation regularization (2019)

In optoacoustic tomography, image reconstruction is often performed with incomplete or noisy data, leading to reconstruction errors. Significant improvement in reconstruction accuracy may be achieved in such cases by using nonlinear regularization schemes, such as total-variation minimization and <i>L</i> <sub>1</sub>-based sparsity-preserving schemes. In this paper, we introduce a new framework for optoacoustic image reconstruction based on adaptive anisotropic total-variation regularization, which is more capable of preserving complex boundaries than conventional total-variation regularization. The new scheme is demonstrated in numerical simulations on blood-vessel images as well as on experimental data and is shown to be more capable than the total-variation-<i>L</i> <sub>1</sub> scheme in enhancing image contrast.
Evaluation of surface contamination of titanium dental implants by LV-SEM: comparison with XPS measurements (1997)

Low-voltage scanning electron microscopy (LV-SEM) was used to monitor contamination by carbonaceous compounds on the surface of two different commercially available titanium dental implants. Because of its higher surface sensitivity, the LV mode allows us to image contaminating materials on surfaces that are undetected by conventional SEM. Results stemming from LV-SEM observations were compared to surface composition data obtained by XPS analysis. A good relationship between findings obtained by the two techniques was found. © 1997 John Wiley & Sons, Ltd.
&lt;title&gt;Transmission and reflection properties of periodic dispersive materials&lt;/title&gt; (1994)

The transfer matrix method has been used for the calculation of transmission and reflection properties of periodic and/or disordered dispersive photonic band gap (PBG) materials. We have studied the transmission properties of: (1) PBG materials constructed of low resistive Si wafers forming the newly proposed layer-by-layer structure and exhibiting PBG at around 100 GHz; (2) a two-dimensional square lattice consisting of metallic wires; (3) materials having structural gaps close to a polariton gap.
Heat/Mass Transfer in Rotating, Smooth, High Aspect-Ratio (4:1) Coolant Channels With Curved Walls in 90° and 45° Orientation (2008)

The paper presents an experimental study of heat/mass transfer coefficient in 4:1 aspect ratio smooth channels with non-uniform cross-sections. Curved leading and trailing walls are studied for two curvatures and for two different curvature configurations. One configuration has curved walls with curvature corresponding to the blade profile (positive curvature on both leading and trailing walls), and the other configuration has leading and trailing walls that curve inwards into the coolant passage (negative curvature on the leading surface and positive curvature on the trailing surface). The experiments are conducted in a rotating two-pass coolant channel facility using the naphthalene sublimation technique. Only the radially outward flow is considered for the present study at a Reynolds number of 20,000, rotation numbers in the range 0–0.051 and for 90° and 45° orientations with respect to the direction of rotation. In addition to area averaged values, the span-wise mass transfer distributions of fully developed regions of the channel walls are presented in order to delineate the effects of rotation number, channel shape and orientation. The mass transfer data from the curved wall channels are compared to those from a smooth 4:1 rectangular duct with similar flow parameters. Pressure drop along each channel is also measured and put in perspective of the mass/heat transfer results for the 90° orientation, through the presentation of a performance factor.
Neural information retrieval: at the end of the early years (2017)

A recent “third wave” of neural network (NN) approaches now delivers state-of-the-art performance in many machine learning tasks, spanning speech recognition, computer vision, and natural language processing. Because these modern NNs often comprise multiple interconnected layers, work in this area is often referred to as deep learning. Recent years have witnessed an explosive growth of research into NN-based approaches to information retrieval (IR). A significant body of work has now been created. In this paper, we survey the current landscape of Neural IR research, paying special attention to the use of learned distributed representations of textual units. We highlight the successes of neural IR thus far, catalog obstacles to its wider adoption, and suggest potentially promising directions for future research.
Protective effects of tyndallized Lactobacillus�acidophilus IDCC 3302 against UVB‑induced photodamage to epidermal keratinocytes cells (2019)

Photoaging is a consequence of chronic exposure to ultraviolet (UV) radiation and results in skin damage. In this study, whether tyndallizate of the probiotic bacterium Lactobacillus acidophilus IDCC 3302 (ACT 3302) can protect against UVB‑induced photodamage to the skin was investigated. For this, HaCaT keratinocytes were used as a model for skin photoaging. HaCaT cells were treated with ACT 3302 prior to UVB exposure and skin hydration factors and matrix metalloproteinase (MMP)‑1, MMP‑2, and MMP‑9 levels in the culture supernatant were evaluated by ELISA. The protective effects of ACT 3302 against UVB‑induced oxidative stress in HaCaT cells was also assessed by measuring superoxide dismutase and catalase activity and detecting the expression of pro‑inflammatory cytokine‑encoding genes and mitogen‑activated protein kinase (MAPK) signaling components by reverse transcription‑quantitative polymerase chain reaction and western blotting, respectively. UVB exposure increased MMP expression and MAPK activation; these changes were attenuated by pretreatment with ACT 3302. Treatment with ACT 3302 prior to UVB exposure also attenuated inflammation. These results demonstrate that tyndallized ACT 3302 can mitigate photodamage to the skin induced by UVB radiation through the suppression of MMPs and could therefore be used clinically to prevent wrinkle formation.
Ice nucleation by smectites: the role of the edges (2023)

Abstract. Smectites, like other clay minerals, have been shown to promote ice nucleation in the immersion freezing mode and likely contribute to the population of ice-nucleating particles (INPs) in the atmosphere. Smectites are layered aluminosilicates, which form platelets that depending on composition might swell or even delaminate in water by intercalation of water molecules between their layers. They comprise among others montmorillonites, hectorites, beidellites, and nontronites. In this study, we investigate the ice nucleation (IN) activity of a variety of natural and synthetic smectite samples with different exchangeable cations. The montmorillonites STx-1b and SAz-1, the nontronite SWa-1, and the hectorite SHCa-1 are all rich in Ca2+ as the exchangeable cation; the bentonite MX-80 is rich in Na+ with a minor contribution of Ca2+, and the synthetic Laponite is a pure Na+ smectite. The bentonite SAu-1 is rich in Mg2+ with a minor contribution of Na+, and the synthetic interstratified mica-montmorillonite Barasym carries NH4+ as the exchangeable cation. In emulsion freezing experiments, all samples except Laponite exhibited one or two heterogeneous freezing peaks with onsets between 239 and 248 K and a quite large variation in IN activity yet without clear correlation with the exchangeable cation, with the type of smectite, or with mineralogical impurities in the samples. To further investigate the role of the exchangeable cation, we performed ion exchange experiments. Replacing NH4+ with Ca2+ in Barasym reduced its IN activity to that of other Ca-rich montmorillonites. In contrast, stepwise exchange of the native cations in STx-1b once with Y3+ and once with Cu2+ showed no influence on IN activity. However, aging of smectite suspensions in pure water up to several months revealed a decrease in IN activity with time, which we attribute to the delamination of smectites in aqueous suspensions, which may proceed over long timescales. The dependence of IN activity on platelet stacking and thickness can be explained if the hydroxylated chains forming at the edges are the location of ice nucleation in smectites, since the edges need to be thick enough to host a critical ice embryo. We hypothesize that at least three smectite layers need to be stacked together to host a critical ice embryo on clay mineral edges and that the larger the surface edge area is, the higher the freezing temperature. Comparison with reported platelet thicknesses of the investigated smectite samples suggests that the observed freezing temperatures are indeed limited by the surface area provided by the mostly very thin platelets. Specifically, Laponite, which did not show any IN activity, is known to delaminate into single layers of about 1 nm thickness, which would be too thin to host a critical ice embryo.
Selective Deletion of Heparan Sulfotransferase Enzyme, Ndst1, in Donor Endothelial and Myeloid Precursor Cells Significantly Decreases Acute Allograft Rejection (2018)

Early damage to transplanted organs initiates excess inflammation that can cause ongoing injury, a leading cause for late graft loss. The endothelial glycocalyx modulates immune reactions and chemokine-mediated haptotaxis, potentially driving graft loss. In prior work, conditional deficiency of the glycocalyx-modifying enzyme N-deacetylase-N-sulfotransferase-1 (Ndst1<sup>f/f</sup> TekCre<sup>+</sup>) reduced aortic allograft inflammation. Here we investigated modification of heparan sulfate (HS) and chemokine interactions in whole-organ renal allografts. Conditional donor allograft Ndst1 deficiency (Ndst1<sup>-/-</sup>; C57Bl/6 background) was compared to systemic treatment with M-T7, a broad-spectrum chemokine-glycosaminoglycan (GAG) inhibitor. Early rejection was significantly reduced in Ndst1<sup>-/-</sup> kidneys engrafted into wildtype BALB/c mice (Ndst1<sup>+/+</sup>) and comparable to M-T7 treatment in C57Bl/6 allografts (P < 0.0081). M-T7 lost activity in Ndst1<sup>-/-</sup> allografts<sup>,</sup> while M-T7 point mutants with modified GAG-chemokine binding displayed a range of anti-rejection activity. CD3+ T cells (P < 0.0001), HS (P < 0.005) and CXC chemokine staining (P < 0.012), gene expression in NFκB and JAK/STAT pathways, and HS and CS disaccharide content were significantly altered with reduced rejection. Transplant of donor allografts with conditional Ndst1 deficiency exhibit significantly reduced acute rejection, comparable to systemic chemokine-GAG inhibition. Modified disaccharides in engrafted organs correlate with reduced rejection. Altered disaccharides in engrafted organs provide markers for rejection with potential to guide new therapeutic approaches in allograft rejection.
Arthroscopic rotator interval repair: the three‐step all‐inside technique (2004)

Many clinical reports have emphasized the importance of rotator interval lesions in patients with glenohumeral instability, and many investigators have described open repair techniques, either as a supplement to other capsule reconstruction or as an isolated procedure. In this article, an original arthroscopic technique for rotator interval closure is described. This technique allows the operator to accurately manage the degree of tightening of the rotator interval, the knot tying, and the suture cutting, under direct intra-articular arthroscopic vision.
Establishment and Characterization of 6‐[[2‐(Dimethylamino)ethyl]amino]‐3‐hydroxy‐7H‐indeno[2,1‐<i>c</i>]quinolin‐7‐one dihydrochloride (TAS‐103)‐resistant Cell Lines (2000)

6-2-(Dimethylamino)ethylămino-3-hydroxy-7H-indeno2, 1-cquinolin-7-one dihydrochloride (TAS-103) is a novel anticancer agent that was developed to target both topoisomerase (Topo) I and Topo II. To elucidate its mechanism of action, we have established and characterized TAS-103-resistant cells, derived from mouse leukemia (P388), human colon cancer (DLD-1), and human lung adenocarcinoma (A549) cell lines, by exposure to stepwisely increasing concentrations of TAS-103 in the culture medium. P388 / TAS cells showed only cross-resistance to VP-16 and adriamycin (ADR). The Topo II activity in these cells was decreased to below one-fourth of that in the parental cells, while the Topo I activity remained unchanged. DLD / TAS cells appeared to be cross-resistant to VP-16, ADR, camptothecin (CPT), SN-38 and vincristine (VCR). The enzymatic activities of both Topo I and Topo II in these cells were decreased to one-fourth of that observed in the parental cells. Furthermore, the decreased activities were accompanied by lower expression at the mRNA and protein levels. A549 / TAS cells acquired cross-resistance to VP-16, ADR and VCR, though the Topo activities were virtually unchanged. In this cell line, the intracellular accumulation of TAS-103 was significantly decreased and the expression of multidrug resistance associated protein (MRP) was elevated when compared with the parental cells. The results indicate that the affected activities of Topo I and / or Topo II, and in some instances decreased accumulation of TAS-103, are associated with the development of resistance to TAS-103, although the main mechanism of resistance to TAS-103 varied among cell lines.
Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTFormation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization ReactionsSteven R. Angle, Damian O. Arnaiz, James P. Boyce, Rogelio P. Frutos, Michael S. Louie, Heather L. Mattson-Arnaiz, Jon D. Rainier, Kenneth D. Turnbull, and Wenjin YangCite this: J. Org. Chem. 1994, 59, 21, 6322–6337Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jo00100a039https://doi.org/10.1021/jo00100a039research-articleACS PublicationsRequest reuse permissionsArticle Views794Altmetric-Citations41LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts