gebhart/patrepeval huggingface dataset:
Aspects of hydrodynamic shear regulating shear-induced platelet activation and self-association of von Willebrand factor in suspension (2003)

The binding of plasma von Willebrand factor (VWF) to platelet receptor GpIb under high hydrodynamic shear leads to platelet activation and subsequent shear-induced platelet aggregation (SIPA). We quantitatively examined the aspects of fluid flow that regulate platelet activation by subjecting human blood and isolated platelets to well-defined shear conditions in a cone-plate viscometer. We made the following observations. First, Annexin V binding to phosphatidyl serine expressed on activated cells was detectable within 10 seconds of shear application. Second, fluid shear stress rather than shear rate controls platelet activation, and a threshold shear stress of approximately 80 dyn/cm(2) is necessary to induce significant activation. Under these conditions, individual domains of soluble VWF and platelet GpIb are subjected to similar magnitudes of fluid forces on the order of 0.1 pN, whereas GpIb with bound VWF is subjected to 1 pN. Third, cell-cell collisions and time-varying stresses are not essential for platelet activation. Fourth, the mechanism of platelet activation can be resolved in 2 steps based on the contribution of VWF and fluid forces. Fluid shear and VWF are required during the first step, when GpIb-VWF binding likely occurs. Subsequently, high shear forces alone in the absence of VWF in suspension can induce platelet activation. In other experiments, purified VWF was subjected to shear in the viscometer, and VWF morphology was assessed using light scattering. These studies demonstrate, for the first time, the ability of hydrodynamic forces to induce VWF aggregation in suspension. This VWF self-association may be an additional feature involved in controlling cell adhesion rates in circulation.
Sleep disorders and work performance: findings from the 2008 National Sleep Foundation Sleep in America poll (2010)

Chronic sleep deprivation is common among workers, and has been associated with negative work outcomes, including absenteeism and occupational accidents. The objective of the present study is to characterize reciprocal relationships between sleep and work. Specifically, we examined how sleep impacts work performance and how work affects sleep in individuals not at-risk for a sleep disorder; assessed work performance outcomes for individuals at-risk for sleep disorders, including insomnia, obstructive sleep apnea (OSA) and restless legs syndrome (RLS); and characterized work performance impairments in shift workers (SW) at-risk for shift work sleep disorders relative to SW and day workers. One-thousand Americans who work 30 h per week or more were asked questions about employment, work performance and sleep in the National Sleep Foundation's 2008 Sleep in America telephone poll. Long work hours were associated with shorter sleep times, and shorter sleep times were associated with more work impairments. Thirty-seven percent of respondents were classified as at-risk for any sleep disorder. These individuals had more negative work outcomes as compared with those not at-risk for a sleep disorder. Presenteeism was a significant problem for individuals with insomnia symptoms, OSA and RLS as compared with respondents not at-risk. These results suggest that long work hours may contribute to chronic sleep loss, which may in turn result in work impairment. Risk for sleep disorders substantially increases the likelihood of negative work outcomes, including occupational accidents, absenteeism and presenteeism.
Non-Faradaic electrochemical sensors: principles and practice (1991)

D. B. Kell, A. M. Woodward, N. J. Cade, T. K. Gibbs, P. J. Iredale and D. A. Williams, Anal. Proc., 1991, 28, 378 DOI: 10.1039/AP9912800378
OpToGen — A genetic algorithm based framework for optimal topology generation for linear networks (2017)

Smart transportation is one of the essential components of smart cities that involves sensing traffic and pedestrians. Wireless Sensor Networks (WSN) have extensively been utilized over the years for sensing and data transfer in diverse structural deployments including mesh, ad hoc and hierarchical layouts. Several applications of WSN may involve placing the nodes in a linear topology, constituting a special class of networks called Linear Networks. Such networks are being used in smart cities to collect data from roads and highways. Additionally, in a densely deployed linear network case, issues related to optimal resource allocation and networking may persist because the standard network protocols attempt to manage the network as a mesh or an ad hoc infrastructure. In this paper, we present an optimal topology generation (OpToGen) framework that uses Genetic Algorithm (GA) to configure and deploy a heterogeneous wireless network for linear infrastructures. OpToGen framework is scalable to multiple tiers and the use of GA results in less computational overhead and fast convergence to optimal topologies that are verified by a discrete event simulator.
Brillouin Optical Time-Domain Distributed Analysis of Cladding Modes in a Coated Fiber (2022)

Brillouin optical time domain analysis of coupling to cladding modes of standard, coated fiber is demonstrated. Uncertainty in local changes of effective indices is below 10 -6 RIU. Local effect of acetone on coating is identified.
Ten tips to encourage student interaction with screen-capture type vodcasts (2018)

Video podcasts (vodcasts) are gaining popularity in medical education, but they can be a passive learning modality if students do not actively engage with the content. Of the two categories of vodcast software, screen-capture (mp4 output) and Flash™ (HTML5/Flash output), screen-capture has greater potential to result in passive learning because students cannot physically interact with the content. However, screen-capture offers several advantages for the producer (often faculty) and the consumer (students). As such, this type of software is popular with medical school faculty. To encourage active learning, ten tips are presented with specific strategies that faculty can use with screen-capture type vodcasts. Many of the tips also apply to Flash-type vodcasts. By incorporating these strategies, faculty with limited technical abilities can create engaging vodcasts that stimulate active learning.
A Functional Polymorphism in <b> <i>RGS6</i> </b> Modulates the Risk of Bladder Cancer (2004)

RGS proteins negatively regulate heterotrimeric G protein signaling. Recent reports have shown that RGS proteins modulate neuronal, cardiovascular, and lymphocytic activity, yet their role in carcinogenesis has not been explored. In an epidemiologic study of 477 bladder cancer patients and 446 matched controls, three noncoding single-nucleotide polymorphisms (SNPs) in RGS2 and RGS6 were each associated with a statistically significant reduction in bladder cancer risk. The risk of bladder cancer was reduced by 74% in those individuals with the variant genotype at all three SNPs (odds ratio, 0.26; 95% confidence interval, 0.09-0.71). When the SNPs were analyzed separately, the RGS6-rs2074647 (C-->T) polymorphism conferred the greatest overall reduction in risk of bladder cancer (odds ratio, 0.66; 95% confidence interval, 0.46-0.95). These reductions in risk were more pronounced in ever smokers, suggesting a gene-environment interaction. In transfection assays, the RGS6-rs2074647 (C-->T) polymorphism increased the activity of a luciferase-RGS fusion protein by 2.9-fold, suggesting that this SNP is functionally significant. Finally, we demonstrate that RGS2 transcripts and several splice variants of RGS6 are expressed in bladder cancer cells. These data provide the first evidence that RGS proteins may be important modulators of cancer risk and validate RGS6 as a target for further study.
Apical membrane antigen 1 plays a central role in erythrocyte invasion by <i>Plasmodium</i> species (2000)

Apical membrane antigen 1 (AMA1) is an asexual blood-stage protein expressed in the invasive merozoite form of Plasmodia species, which are the causative agent of malaria. We have complemented the function of Plasmodium falciparum AMA1 (PfAMA1) with a divergent AMA1 transgene from Plasmodium chabaudi (PcAMA1). It was not possible to disrupt the PfAMA1 gene using 'knock-out' plasmids, although we demonstrate that the PfAMA1 gene can be targeted by homologous recombination. These experiments suggest that PfAMA1 is critical, perhaps essential, for blood-stage growth. Importantly, we showed that PcAMA1 expression in P. falciparum provides trans-species complementation to at least 35% of the function of endogenous PfAMA1 in human red cells. Furthermore, expression of this transgene in P. falciparum leads to more efficient invasion of murine erythrocytes. These results indicate an important role for AMA1 in the invasion of red blood cells (RBCs) across divergent Plasmodium species.
Heterocyclic Synthesis and Therapeutic Chemistry: A Successful Marriage (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Suture-related keratitis following cataract surgery caused by methicillin-resistant Staphylococcus aureus (2010)

A 54-year old-man presented with a two-day history of severe pain and decreased vision. Examination revealed a corneal ulcer associated with a loose suture from cataract surgery done approximately two years ago. The suture was removed and the patient was started on topic antibiotic treatment with cefazolin and gentamycin. Cultures revealed methicillin-resistant Staphylococcus aureus (MRSA). The antibiotic regimen was changed to include vancomycin but the ulcer continued to progress. Three days later, the ulcer had perforated and an emergent corneal patch graft was performed. To our knowledge, this is the first reported case of suture-related MRSA keratitis after uncomplicated clear corneal cataract surgery.
Multi-Iron Tungstodiarsenates. Synthesis, Characterization, and Electrocatalytic Studies of αββα-(Fe<sup>III</sup>OH<sub>2</sub>)<sub>2</sub>Fe<sup>III</sup><sub>2</sub>(As<sub>2</sub>W<sub>15</sub>O<sub>56</sub>)<sub>2</sub><sup>12</sup><sup>-</sup> (2003)

Reaction of the trivacant lacunary complex, alpha-Na(12)[As(2)W(15)O(56)], with an aqueous solution of Fe(NO(3))(3).9H(2)O yields the sandwich-type polyoxometalate, alphabetabetaalpha-Na(12)(Fe(III)OH(2))(2)Fe(III)(2)(As(2)W(15)O(56))(2) (Na1). The structure of this complex, determined by single-crystal X-ray crystallography (a = 13.434(1) A, b = 13.763(1) A, c = 22.999(2) A, alpha = 90.246(2) degrees, beta = 102.887(2) degrees, gamma = 116.972(1) degrees, triclinic, Ponemacr;, R1 = 5.5%, based on 25342 independent reflections), consists of an Fe(III)(4) unit sandwiched between two trivacant alpha-As(2)W(15)O(56)(12)(-) moieties. UV-vis, infrared, cyclic voltammetry, and elemental analysis data are all consistent with the structure determined from X-ray analysis. Magnetization studies confirm that the four Fe(III) centers are antiferromagnetically coupled. A cyclic voltammogram of Na1 reveals that a three-wave W(VI) system replaces the two-wave W(VI) system found in the precursor alpha-As(2)W(15)O(56)(12)(-) complex. The observed modifications in the CV patterns of Na1 and alpha-As(2)W(15)O(56)(12)(-) are most likely due to subsequent changes in the acid-base properties of two reduced POMs that occur as a result of Fe(III) incorporation. Na1 is shown to be more efficient than the monosubstituted complex alpha(2)-As(2)(Fe(III)OH(2))W(17)O(61)(7)(-) in the electrocatalytic reduction of dioxygen. This is attributed to cooperativity effects among the adjacent Fe(III) centers in Na1.
System for integrated interstitial photodynamic therapy and dosimetric monitoring (2005)

Photodynamic therapy for the treatment of cancer relies on the presence of light, sensitizer and oxygen. By monitoring these three parameters during the treatment a better understanding and treatment control could possibly be achieved. Here we present data from in vivo treatments of solid skin tumors using an instrument for interstitial photodynamic therapy with integrated dosimetric monitoring. By using intra-tumoral ALA-administration and interstitial light delivery solid tumors are targeted. The same fibers are used for measuring the fluence rate at the treatment wavelength, the sensitizer fluorescence and the local blood oxygen saturation during the treatment. The data presented is based on 10 treatments in 8 patients with thick basal cell carcinomas. The fluence rate measurements at 635 nm indicate a major treatment induced absorption increase, leading to a limited light penetration at the treatment wavelength. This leads to a far from optimal treatment since the absorption increase prevents peripheral tumor regions from being fully treated. An interactive treatment has been implemented assisting the physician in delivering the correct light dose. The absorption increase can be compensated for by either prolonging the treatment time or increasing the output power of each individual treatment fiber. The other parameters of importance, i.e. the sensitizer fluorescence at 705 nm and the local blood oxygen saturation, are monitored in order to get an estimate of the amount of photobleaching and oxygen consumption. Based on the oxygen saturation signal, a fractionized irradiation can be introduced in order to allow for a re-oxygenation of the tissue.
FBMC System: An Insight into Doubly Dispersive Channel Impact (2016)

It has been claimed that filter bank multicarrier (FBMC) systems suffer from negligible performance loss caused by moderate dispersive channels in the absence of guard time protection between symbols. However, a theoretical and systematic explanation/analysis for the statement is missing in the literature to date. In this paper, based on one-tap minimum mean square error (MMSE) and zero-forcing (ZF) channel equalizations, the impact of doubly dispersive channel on the performance of FBMC systems is analyzed in terms of mean square error of received symbols. Based on this analytical framework, we prove that the circular convolution property between symbols and the corresponding channel coefficients in the frequency domain holds loosely with a set of inaccuracies. To facilitate analysis, we first model the FBMC system in a vector/matrix form and derive the estimated symbols as a sum of desired signal, noise, intersymbol interference (ISI), intercarrier interference (ICI), interblock interference (IBI), and estimation bias in the MMSE equalizer. Those terms are derived one-by-one and expressed as a function of channel parameters. The numerical results reveal that under harsh channel conditions, e.g., with large Doppler spread or channel delay spread, the FBMC system performance may be severely deteriorated and error floor will occur.
ChemInform Abstract: Alkynylations of Oxiranes with Lithium Acetylides by the Catalysis of Trimethylgallium. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Dispersion-accumulated diffraction-compensated superprism with two cascaded photonic crystals (2012)

The benefits of unusual dispersive properties of photonic crystals are often mitigated by unwanted phenomena like spatial broadening of propagating beams. This problem is usually faced using millimeter long conditioning regions to precompensate for beam spreading. A new approach is explored here to manage the strong diffraction of photonic superprisms without preconditioning regions. Unconventional photonic crystal lattice cells are engineered using plane wave expansion calculations, and two photonic crystals having both positive dispersions but diffraction properties of opposite signs are selected. Light propagation in the combined photonic structure is studied using finite difference time domain simulation to validate the predicted dispersion accumulation and diffraction compensation approach.
Inhibition of theophylline clearance by coadministered ofloxacin without alteration of theophylline effects (1987)

The influence of multiple doses of ofloxacin (ORF 18489) on the disposition of theophylline was studied in 15 male volunteers. Subjects were confined in the Clinical Research Unit for 13 days and given a xanthine-free diet. A single dose (3 mg/kg) of theophylline was given orally, and blood samples were collected at fixed time intervals for 36 h. The concentrations of theophylline were measured with TDX (Abbott Diagnostics, Irving, Tex.), and clearance was calculated. Theophylline clearance was used to individualize subsequent doses to achieve average steady-state theophylline concentrations in plasma of 10 mg/liter. Individualized theophylline doses were administered every 8 h until steady-state conditions were reached. Theophylline clearance was determined again at steady state and on days 7 and 8. On day 8, ofloxacin (400 mg every 12 h) was given concomitantly with theophylline. Theophylline clearance was measured again on day 12, after the last theophylline dose. Administration of ofloxacin for 1 day did not change theophylline clearance, but coadministration for 4 days significantly decreased theophylline clearance by 12.1% (P less than 0.05). The area under the concentration-time curve for theophylline increased 9.9% (P less than 0.05), and average steady-state concentrations in plasma increased 10.3% (P less than 0.05). Despite changes in clearance, adverse effects of theophylline did not increase during coadministration of ofloxacin. Although statistically significant, the interaction between ofloxacin and theophylline is unlikely to be of major clinical importance.
Estimation of Diffuse Fraction of Global Solar Radiation Using Artificial Neural Networks (2009)

Abstract Measured daily mean air temperature and relative humidity values between 1998 and 2002 for Abha city in Saudi Arabia were used for predicting diffuse fraction of solar radiation in future time domain using artificial neural networks method. The estimations of diffuse solar radiation were made using four combinations of data sets, viz. (i) day of the year and daily maximum air temperature as inputs and diffuse solar radiation as output, (ii) day of the year and daily minimum air temperature as inputs and diffuse solar radiation as output, (iii) day of the year and daily mean air temperature as inputs and diffuse solar radiation as output, and (iv) time day of the year, daily mean air temperature, and relative humidity as inputs and diffuse solar radiation as output. The measured data between 1998 and 2001 was used for training the neural networks while the remaining 250 days' data from 2002 was used as testing data. The testing data was not used in training the neural networks. Obtained results show that neural networks are well capable of estimating diffuse solar radiation from temperature and relative humidity. This can be used for estimating diffuse solar radiation for locations where only temperature and humidity data are available.
Abstract WMP90: Comparison of Acute Ischemic Stroke Care Between Comprehensive Stroke Centers and Primary Stroke Centers Participating in Get With the Guidelines-Stroke (2018)

Background: To improve stroke care, the Brain Attack Coalition recommended establishing primary stroke center (PSC) and comprehensive stroke center (CSC) certification. Achieving CSC designation requires the ability to provide more complex services. However, it remains unknown whether CSCs have better performance than PSCs for ischemic stroke care. This study compared ischemic stroke care between CSCs and PSCs. Methods: The study included consecutive patients who were admitted to the 134 CSCs and 1047 PSCs participating in Get With The Guidelines (GWTG)-Stroke between January 1, 2013 and December 31, 2015 with a final diagnosis of acute ischemic stroke. Multivariable logistic regression models were generated to examine the association between stroke center certification (CSC vs PSC) and performance measures and outcomes, after adjusting for potential confounders including patient and hospital characteristics. Results: Of the 605,136 patients who were admitted directly from the emergency department, 110,624 were admitted to CSCs and 494,512 to PSCs. CSCs were larger than PSCs (median number of beds 481 vs 263). Performance differences between CSCs vs. PSCs are shown in the table. CSCs and PSCs had comparable overall conformity to the seven performance measures represented by the summary defect-free care measure. CSCs outperformed PSCs in several key measures, especially the use of intravenous tissue plasminogen activator (IV tPA) and intra-arterial thrombectomy (IA-therapy). Compared with patients at PSCs, patients at CSCs were more likely to receive IV tPA in both unadjusted and adjusted models. The door to IV tPA time was shorter at CSCs. Patients at CSCs were more likely to receive IA therapy, with shorter door to IA therapy times. Mortality was higher at CSCs. Conclusions: Stroke care at CSCs exceeded PSCs for many but not all quality measures, particularly timely acute reperfusion therapy. Risk adjusted in-hospital mortality was modestly higher at CSCs.
Hepatitis Delta Virus Antibodies in Hepatitis B Surface Antigen Asymptomatic Carriers in Senegal (1990)

Journal Article Hepatitis Delta Virus Antibodies in Hepatitis B Surface Antigen Asymptomatic Carriers in Senegal Get access Abdelkader Bacha, Abdelkader Bacha Faculty of Medicine and Pharmacy. University Cheikh Anta Diop, Dakar, Senegal, and Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Philippe Roingeard, Philippe Roingeard Faculty of Medicine and Pharmacy. University Cheikh Anta Diop, Dakar, Senegal, and Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Awa Marie Coli, Awa Marie Coli Faculty of Medicine and Pharmacy. University Cheikh Anta Diop, Dakar, Senegal, and Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar Max Essex, Max Essex Faculty of Medicine and Pharmacy. University Cheikh Anta Diop, Dakar, Senegal, and Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts Reprints and correspondence: Dr. Max Essex, Departmentof Cancer Biology, Harvard School of Public Health, 665 Huntington Ave., Boston, MA 02115. Search for other works by this author on: Oxford Academic PubMed Google Scholar Souleymane M'Boup Souleymane M'Boup Faculty of Medicine and Pharmacy. University Cheikh Anta Diop, Dakar, Senegal, and Department of Cancer Biology, Harvard School of Public Health, Boston, Massachusetts Search for other works by this author on: Oxford Academic PubMed Google Scholar The Journal of Infectious Diseases, Volume 161, Issue 1, January 1990, Pages 150–151, https://doi.org/10.1093/infdis/161.1.150 Published: 01 January 1990
Effect of ethanol on arachidonic acid metabolism in macrophages. (1992)

The authors report preliminary data on the production of arachidonic acid metabolites by ethanol stimulated macrophages. They focus on the substantial implications for understanding the pathobiology of alcoholism.