gebhart/patrepeval huggingface dataset:
Clinical outcome prediction after thrombectomy of proximal middle cerebral artery occlusions by the appearance of lenticulostriate arteries on magnetic resonance angiography: A retrospective analysis (2017)

Post-ischemic vasodynamic changes in infarcted brain parenchyma are common and range from hypo- to hyperperfusion. In the present study, appearance of the lenticulostriate arteries (LSAs) on postinterventional 3T time-of-flight (TOF)-MRA suggestive for altered post-stroke vasodynamics following thrombectomy was investigated. Patients who underwent thrombectomy for a proximal MCA occlusion and for whom postinterventional 3T TOF-MRA (median at day 3) was available, were included in this retrospective analysis (n=98). LSA appearance was categorized into presence (LSA-sign<sup>+</sup>) or absence (LSA-sign<sup>-</sup>) of vasodilatation in the ischemic hemisphere. Functional outcome was determined using the modified Rankin scale (mRS). LSA-sign<sup>+</sup> was observed in 64/98 patients. Hypertension (adjusted OR: 0.171, 95% CI: 0.046-0.645) and preinterventional IV rtPA (adjusted OR: 0.265, 95% CI: 0.088-0.798) were associated with absence of the LSA-sign<sup>+</sup>. In multivariate logistic regression, LSA-sign<sup>+</sup> was associated with substantial neurologic improvement (adjusted OR: 10.18, 95% CI: 2.69-38.57) and good functional outcome (discharge-mRS ≤ 2, adjusted OR: 7.127, 95% CI: 1.913-26.551 and day 90 mRS ≤ 2, adjusted OR: 3.786, 95% CI: 1.026-13.973) after correcting for relevant confounders. For all clinical endpoints, model fit improved when including the LSA-sign term (p<0.05). Asymmetrical dilatation of LSAs following successful thrombectomy indicates favorable neurologic and mid-term functional outcomes. This may indicate preserved cerebral blood flow regulatory mechanisms.
Suspension force investigation for consequent-pole and surface-mounted permanent magnet bearingless motors with concentrated winding (2015)

This paper discusses the suspension force of consequent-pole permanent magnet (CPM) and surface-mounted permanent magnet (SPM) bearingless motors with two-independent three-phase concentrated windings for motor and magnetic suspension. Influence of spatial harmonics in the magneto-motive force (MMF) distribution caused by the concentrated winding on the suspension force profile is analytically investigated. We have demonstrated that 12-slot/10-pole SPM bearingless motor produces stable suspension force, whereas 9-slot/8-pole CPM and SPM bearingless motors and 12-slot/10-pole CPM bearingless motor have significant force ripple caused by the harmonics in the MMF distribution. We fabricated a prototype SPM bearingless motor that has three-phase 10-pole and 8-pole concentrated windings in the 12-slot stator for motor and magnetic suspension, respectively. The magnetically suspended rotor was stably driven up to 6000 r/min. In the rotation test, interference of the motor current with the suspension force under loaded and unloaded conditions was not observed.
Wireless sensing with smart skins (2011)

The ever-increasing need for perpetual ubiquitous cognition of our environment prompts the integration of numerous unobtrusive, extremely low-cost and passively powered wireless sensors into our surroundings. Smart skins, i.e. thin layers of modified materials on top of surfaces that surround our every-day lives, constitute ideal such sensor candidates for the ubiquitous awareness vision. In this paper we are presenting three different types of highly sensitive smart skin sensors for identity and genuineness authentication and seal proof, large metallic structural strain and crack detection and chemical gas sensing of ammonia and nitrogen dioxide. These low-profile smart skin prototypes share not only all the aforementioned desired characteristics but also exhibit high levels of accuracy and reliability in a flexible and rugged design.
DGD1-independent biosynthesis of extraplastidic galactolipids after phosphate deprivation in <i>Arabidopsis</i> (2000)

The galactolipids, mono- and digalactosyldiacylglycerol (DGDG), are the most common nonphosphorous lipids in the biosphere and account for 80% of the membrane lipids found in green plant tissues. These lipids are major constituents of photosynthetic membranes (thylakoids), and a large body of evidence suggests that galactolipids are associated primarily with plastid membranes in seed plants. A null-mutant of Arabidopsis (dgd1), which lacks the DGDG synthase (DGD1) resulting in a 90% reduction in the amount of DGDG under normal growth conditions, accumulated DGDG after phosphate deprivation up to 60% of the amount present in the wild type. This observation suggests the existence of a DGD1-independent pathway of galactolipid biosynthesis. The fatty acid composition of the newly formed DGDG was distinct, showing an enrichment of 16-carbon fatty acids in the C-1 position of the glycerol backbone of DGDG. Roots with their rudimentary plastids accumulated large amounts of DGDG after phosphate deprivation, suggesting that this galactolipid may be located in extraplastidic membranes. Corroborating evidence for this hypothesis was obtained directly by fractionation of subcellular membranes from leaf tissue and indirectly by lipid analysis of the phosphate-deprived fad3 mutant primarily deficient in extraplastidic fatty acid desaturation. The discovery of extraplastidic DGDG biosynthesis induced by phosphate deprivation has revealed a biochemical mechanism for plants to conserve phosphate. Apparently, plants replace phospholipids with nonphosphorous galactolipids if environmental conditions such as phosphate deprivation require this for survival.
Hydraulic parameters of culverts from pipes with normal and spiral form of corrugation (2020)

Abstract The research paper is devoted to study of culverts from metal corrugated pipes (CMP) and helically corrugated steel pipes (HCSP). Modern design solutions of culverts from CMP and HCSP are differ as compared with used before (bottom with various types of roughness, inlet and outlet heads, type and size of corrugation) and there is not enough experimental data for their design. The aim of the study is to test CMP and HCSP models to determine their hydraulic parameters, such as roughness and resistance coefficient, critical bias and so on. The laboratory equipment and method of experimental study as well as results of the tests of CMP and HCSP with protective tray at the pipe bottom and without it under different operation modes are given in the research paper. The results of the study show that roughness coefficient under pressure hade mode can be determined using Norton equation only for HCSP, Norton and Einstein-Banks equations are corrected for CMP.
Proline‐Catalyzed Asymmetric Mannich Reactions: The Highly Enantioselective Synthesis of Amino Acid Derivatives and 1,2‐Amino Alcohols (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
A Motion Sensor-based User Interface for Construction Drawings Navigation (2014)

Today, most viewing of electronic drawings on construction sites takes place on mobile devices with limited screen size. Most of the current software interfaces still use a static display method, scaling drawings to fit the screen. Even though there are limitations because of small screen size on mobile devices, they have the benefit of being equipped with a variety of sensors, such as magnetometers, accelerometers, and gyroscopes. Some studies have looked at the use of these sensors to enhance further user interaction in areas such as gaming and texting. However, no study has considered the design of a user interface for construction drawing navigation using these sensors. To this end, the objective of this study is to develop a touch-free interface to navigate construction drawings using motion sensing. The interface was developed on Apple Inc.'s iOS platform and tested on an iPad tablet device. Motion sensor data, from the accelerometer and gyroscope, were used to pan and zoom the document with spatial movements. This study provides an innovative means to navigate large, layered drawings on small tablet devices. The algorithm used to develop the interface can be embedded in different applications for better navigation of layered construction drawings.
3D coupled electro-mechanics for MEMS: applications of CoSolve-EM (2005)

Micro-electro-mechanical systems (MEMS) are often designed on scales at which electrostatic forces are capable of moving or deforming the parts of the system. In this regime accurate prediction of device behavior may require 3D coupled simulations between the electrostatic and mechanical domains. We have recently developed CoSolve-EM, a coupled solver for 3D quasi-static electro-mechanics. In this paper, we demonstrate the application of CoSolve-EM to five classes of electro-mechanical problems that are often intractable to other techniques. These classes are: devices with electrostatic pull-in instabilities, devices in which precise deformations are required, devices driven by multiple conductors, capacitive sensors that make use of surface contact, and actuators that make use of surface contact.
Reciprocal Regulation Between Smad7 and Sirt1 in the Gut (2018)

In inflammatory bowel disease (IBD) mucosa, there is over-expression of Smad7, an intracellular inhibitor of the suppressive cytokine transforming growth factor-β1, due to post-transcriptional mechanisms that enhance Smad7 acetylation status thus preventing ubiquitination-mediated proteosomal degradation of the protein. IBD-related inflammation is also marked by defective expression of Sirt1, a class III NAD+-dependent deacetylase, which promotes ubiquitination-mediated proteosomal degradation of various intracellular proteins and triggers anti-inflammatory signals. The aim of our study was to determine whether, in IBD, there is a reciprocal regulation between Smad7 and Sirt1. Smad7 and Sirt1 were examined in mucosal samples of IBD patients and normal controls by Western blotting and immunohistochemistry, and Sirt1 activity was assessed by a fluorimetric assay. To determine whether Smad7 is regulated by Sirt1, normal or IBD lamina propria mononuclear cells (LPMC) were cultured with either Sirt1 inhibitor (Ex527) or activator (Cay10591), respectively. To determine whether Smad7 controls Sirt1 expression, <i>ex vivo</i> organ cultures of IBD mucosal explants were treated with Smad7 sense or antisense oligonucleotide. Moreover, Sirt1 expression was evaluated in LPMC isolated from Smad7-transgenic mice given dextran sulfate sodium (DSS). Upregulation of Smad7 was seen in both the epithelial and lamina propria compartments of IBD patients and this associated with reduced expression and activity of Sirt1. Activation of Sirt1 in IBD LPMC with Cay10591 reduced acetylation and enhanced ubiquitination-driven proteasomal-mediated degradation of Smad7, while inhibition of Sirt1 activation in normal LPMC with Ex527 increased Smad7 expression. Knockdown of Smad7 in IBD mucosal explants enhanced Sirt1 expression, thus suggesting a negative effect of Smad7 on Sirt1 induction. Consistently, mucosal T cells of Smad7-transgenic mice contained reduced levels of Sirt1, a defect that was amplified by induction of DSS colitis. The data suggest the existence of a reciprocal regulatory mechanism between Smad7 and Sirt1, which could contribute to amplify inflammatory signals in the gut.
Urine Cytology and Commercially Available Urine-Based Markers for Monitoring of Bladder Urothelial Carcinoma (2007)

Bladder cancer is currently diagnosed using cystoscopy and cytology in patients with suspicious signs and symptoms. These tests are also used to monitor patients with a history of bladder cancer. The recurrence rate for bladder cancer is high, thus necessitating long-term follow-up. Urine cytology requires an experienced cytopathologist. It has high specificity, but low sensitivity for low-grade bladder tumors. Recently, multiple non-invasive urinebased bladder cancer tests have been developed. Many markers have already been approved by the Food and Drug Administration (FDA) for bladder cancer surveillance, but only one marker is approved for detection of bladder cancer in high risk patients (NMP22 BladderChek).
Modulation of the cytotoxicity of mitomycin C to EMT6 mouse mammary tumor cells by dicoumarol in vitro. (1988)

Aerobic and hypoxic cultures of EMT6 mouse mammary tumor cells were used to study the effects of dicoumarol (DIC) on the cytotoxicity of mitomycin C (MC). DIC protected aerobic cells from MC toxicity, but sensitized hypoxic cells to the cytotoxic actions of this antibiotic. Survival curves for cells treated with 1.5 microM MC +/- 100 microM DIC for different periods of time under aerobic or hypoxic conditions showed that DIC acted as a dose-modifying agent, that is, an agent which changed the slopes, but not the shapes, of the MC survival curves. Experiments that examined the effects of the DIC concentration on the modulation of MC cytotoxicity revealed significant perturbations in MC toxicity with a DIC concentration of 100 microM and increased sensitization/protection with increasing levels of DIC. DIC altered the toxicity of MC only when it was present during exposure of the cells to MC. Treatment with DIC before or after (but not during) MC did not alter the amount of cytotoxicity. Addition of DIC to cell cultures seconds before the addition of MC was as effective as addition of DIC 30 min to 2 h before MC. Taken together, these findings suggest that DIC reversibly inhibits one or more enzymes involved in the activation and inactivation of MC, and that this modulation of the enzymatic processing of MC alters the cytotoxicity of the drug.
Detecting Thief Zones in Carbonate Reservoirs by Integrating Borehole Images With Dynamic Measurements: Case Study From the Mauddud Reservoir, North Kuwait (2010)

Summary One of the key issues in creating a good reservoir model in carbonate reservoirs is identifying the horizontal permeability conduits—"thief zones"—if there are any. In the Sabriyah field in Kuwait, dynamic measurements showed evidence of thief zones in the Lower Cretaceous (Albian) Mauddud formation. Early water breakthrough has occurred in some wells. Previous studies indicated that it was very challenging to detect the thinly layered thief zones using conventional openhole logs. This paper describes a method of recognizing the different types of thief zones in the Mauddud carbonate reservoirs using high-resolution image logs with calibration from core and dynamic measurements and by integrating image logs with nuclear magnetic resonance (NMR) and conventional openhole logs. The Mauddud carbonates are Early Albian in age and consist of grainstones, wackstones, and mudstones deposited in a ramp setting. Observations from production logging tools (PLTs) and production data indicated that there are a few thief zones in different levels within the vertical Mauddud sequence. A previous core study shows that the fractures in the Mauddud formation are short (&amp;lt;10 cm) and concentrated in diagenetically cemented layers. The fractured thin layers are believed to be the principal type of thief zone. Another type of thief zone is associated with better-developed vuggy porosity. This study shows that both fractured and vuggy porosity-related types of thief zones can potentially be detected through integration of high-resolution image logs with PLT, NMR, and conventional logs. In addition, methods of estimating fracture permeability and porosity-related permeability based on logs are also proposed. The log-estimated permeability determined using this approach fits better with the production profile and can then be used to evaluate the thief zones in a more quantitative manner.
Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors (2012)

Abstract: Current therapy for ocular allergy includes H 1 antihistamines, mast cell stabilizers, dual action antihistamines (H 1 antihistamines + mast cell stabilizers), and steroids. In this report, we describe the in vivo and in vitro characterization of alcaftadine, a recently approved antihistamine that exhibits a distinct set of therapeutic properties. When tested in a guinea pig model of conjunctivitis, alcaftadine prevented immediate allergic responses with an efficacy comparable with that of ketotifen, and was also able to attenuate delayed eosinophil influx with a potency similar to that of dexamethasone. Given recent reports suggesting a possible role for histamine H 2 or H 4 receptors in the etiology of ocular allergy, we examined the binding properties of alcaftadine at all histamine receptor types. Alcaftadine is a high affinity ligand for the H 1 receptor, with a pK i (8.5) that is comparable with that of other H 1 antihistamines. It also shows an higher affinity for the H 2 receptor than ketotifen. Alcaftadine exhibited modest binding affinity for the H 4 receptor (pK i = 5.8) with no affinity for the H 3 receptor. The affinity for the H 4 is higher than the value for ketotifen (pK i < 5 ). Using a cellular assay of H 4 receptor activity, alcaftadine was shown to act as a functional antagonist of H 4 receptor signaling. Overall, the studies suggest that alcaftadine is a histamine receptor antagonist with a broad spectrum of antihistamine activity and a unique combination of therapeutic effects. As such, it represents a new therapeutic option for the treatment of allergic conditions. Keywords: ocular, allergic conjunctivitis, antihistamine, ketotifen, pheniramine
Novel Motion and Disparity Prediction for Multi-view Video Coding (2014)

This paper presents an efficient motion and disparity prediction method for multi-view video coding based on the high efficient video coding (HEVC) standard. The proposed method exploits inter-view candidates for effective prediction of the motion or disparity vector to be coded. The inter-view candidates include not only the motion vectors of adjacent views, but also global disparities across views. The motion vectors coded earlier in an adjacent view were found to be helpful in predicting the current motion vector to reduce the number of bits used in the motion vector information. In addition, the proposed disparity prediction using the global disparity method was found to be effective for interview predictions. A multi-view version based on HEVC was used to evaluate the proposed algorithm, and the proposed correspondence prediction method was implemented on a multi-view platform based on HEVC. The proposed algorithm yielded a coding gain of approximately 2.9% in a high efficiency configuration random access mode.
Children's Criteria for Representational Adequacy in the Perception of Simple Sonic Stimuli (2010)

This study investigates children's metarepresentational competence with regard to listening to and making sense of simple sonic stimuli. Using diSessa's (2003) work on metarepresentational competence in mathematics and sciences as theoretical and empirical background, it aims to assess children's criteria for representational adequacy of graphical representations of sonic stimuli, as well as to investigate the impact of various factors, such as age, and musical background of the children and the nature of the sound fragments that were represented on the use of these criteria. Four groups of children (8–9 years olds and 11–12 years olds with and without extra music education) were exposed to three short fragments that were distinct from each other by the saliency of one sonic parameter. For each fragment, the children received six pairs of researcher-generated representations, with the representations of each pair differing from each other in terms of the representational criterion being stressed (either correctness, completeness, parsimony, formality, transparency, or beauty). The children had to choose one of both representations from each pair and explain their choice. Generally speaking, our results confirmed three major findings of diSessa (2002) diSessa, A. 2002. “Student's criteria for representational adequacy”. In Symbolizing, modeling and tool use in mathematics education, Edited by: Gravemeijer, K., Lehrer, R., van Oers, B. and Verschaffel, L. 105–129. Dordrecht, , Boston, London: Kluwer Academic Publishers. [Crossref] , [Google Scholar]. They revealed (a) indications of metarepresentational competencies among the children, even among the youngest and musically inexperienced ones, (b) age- and education-related differences with respect to their preferences for certain representational features, and (c) great difficulties among children to articulate their metarepresentational competencies. Theoretical, methodological, and educational implications are discussed.
Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors (2018)

Although the structure of a genetically encoded regulatory circuit is an important determinant of its function, the relationship between circuit topology and the dynamical behaviors it can exhibit is not well understood. Here, we explore the range of behaviors available to the AC-DC circuit. This circuit consists of three genes connected as a combination of a toggle switch and a repressilator. Using dynamical systems theory, we show that the AC-DC circuit exhibits both oscillations and bistability within the same region of parameter space; this generates emergent behaviors not available to either the toggle switch or the repressilator alone. The AC-DC circuit can switch on oscillations via two distinct mechanisms, one of which induces coherence into ensembles of oscillators. In addition, we show that in the presence of noise, the AC-DC circuit can behave as an excitable system capable of spatial signal propagation or coherence resonance. Together, these results demonstrate how combinations of simple motifs can exhibit multiple complex behaviors.
Analysis of requirements for high speed rough terrain autonomous mobility. II. Resolution and accuracy (2002)

A basic requirement of autonomous vehicles is that of guaranteeing the safety of the vehicle by avoiding hazardous situations. This paper analyses this requirement in general terms of the resolution and accuracy of sensors and computations. Several nondimensional expressions emerge which characterize requirements in canonical form.
Oesophagectomy following noncurative endoscopic resection for oesophageal carcinoma: does interval matter? (2022)

It was the first study exploring the relationship between time interval and prognosis in oesophageal cancer. The longer interval between noncurative ER and additional oesophagectomy was associated with a worse DFS, so oesophagectomy was recommended performed within 1 month after ER. Older age, T1b stage, lymphovascular invasion and interval >30 days were significantly associated with pathologic upstage, which is related to the worse outcome too.
Bayesian multiresolution method for local tomography in dental x-ray imaging (2007)

Dental tomographic cone-beam x-ray imaging devices record truncated projections and reconstruct a region of interest (ROI) inside the head. Image reconstruction from the resulting local tomography data is an ill-posed inverse problem. A new Bayesian multiresolution method is proposed for local tomography reconstruction. The inverse problem is formulated in a well-posed statistical form where a prior model of the target tissues compensates for the incomplete x-ray projection data. Tissues are represented in a wavelet basis, and prior information is modeled in terms of a Besov norm penalty. The number of unknowns in the reconstruction problem is reduced by abandoning fine-scale wavelets outside the ROI. Compared to traditional voxel-based models, this multiresolution approach allows significant reduction of degrees of freedom without loss of accuracy inside the ROI, as shown by 2D examples using simulated and in vitro local tomography data.