gebhart/patrepeval huggingface dataset:
Adaptive estimation of rotor time constantforindirect field-oriented induction motor drive (1998)

A novel estimation model based adaptive control for indirect field-oriented induction motor drive is presented. A new coordinate reference frame is utilised to describe the dynamical model of an induction motor. Then, the new reference frame based estimator is proposed to adaptively estimate the redefined state variables and the rotor time constant, necessarily used in indirect field-oriented control. Moreover, a modified estimation model also based on the same reference frame is further presented to simplify the estimation and adaptation computation. By utilisation of the estimation approach, robust indirect-field-oriented control with respect to rotor time constant variation due to the effect of thermal changes is obtained. Finally, simulation and experimental results demonstrate the validity of the approach for practical applications.
Analysis of hospitalized COVID-19 patients in the Mount Sinai Health System using electronic medical records (EMR) reveals important prognostic factors for improved clinical outcomes (2020)

Abstract Importance There is an urgent need to understand patient characteristics of having COVID-19 disease and evaluate markers of critical illness and mortality. Objective To assess association of clinical features on patient outcomes. Design, Setting, and Participants In this observational case series, patient-level data were extracted from electronic medical records for 28,336 patients tested for SARS-CoV-2 at the Mount Sinai Health System from 2/24/ to 4/15/2020, including 6,158 laboratory-confirmed cases. Exposures Confirmed COVID-19 diagnosis by RT-PCR assay from nasal swabs. Main Outcomes and Measures Effects of race on positive test rates and mortality were assessed. Among positive cases admitted to the hospital (N = 3,273), effects of patient demographics, hospital site and unit, social behavior, vital signs, lab results, and disease comorbidities on discharge and death were estimated. Results Hispanics (29%) and African Americans (25%) had disproportionately high positive case rates relative to population base rates ( p &lt;2e-16); however, no differences in mortality rates were observed in the hospital. Outcome differed significantly between hospitals (Gray’s T=248.9; p &lt;2e-16), reflecting differences in average baseline age and underlying comorbidities. Significant risk factors for mortality included age (HR=1.05 [95% CI, 1.04-1.06]; p=1.15e-32), oxygen saturation (HR=0.985 [95% CI, 0.982-0.988]; p=1.57e-17), care in ICU areas (HR=1.58 [95% CI, 1.29-1.92]; p=7.81e-6), and elevated creatinine (HR=1.75 [95% CI, 1.47-2.10]; p=7.48e-10), alanine aminotransferase (ALT) (HR=1.002, [95% CI 1.001-1.003]; p=8.86e-5) white blood cell (WBC) (HR=1.02, [95% CI 1.01-1.04]; p=8.4e-3) and body-mass index (BMI) (HR=1.02, [95% CI 1.00-1.03]; p=1.09e-2). Asthma (HR=0.78 [95% CI, 0.62-0.98]; p=0.031) was significantly associated with increased length of hospital stay, but not mortality. Deceased patients were more likely to have elevated markers of inflammation. Baseline age, BMI, oxygen saturation, respiratory rate, WBC count, creatinine, and ALT were significant prognostic indicators of mortality. Conclusions and Relevance While race was associated with higher risk of infection, we did not find a racial disparity in inpatient mortality suggesting that outcomes in a single tertiary care health system are comparable across races. We identified clinical features associated with reduced mortality and discharge. These findings could help to identify which COVID-19 patients are at greatest risk and evaluate the impact on survival.
Directional emission of stadium-shaped microlasers (2007)

The far-field emission of two-dimensional stadium-shaped dielectric cavities is investigated. Microlasers with such shape present a highly directional emission. We provide experimental evidence of the dependence of the emission directionality on the shape of the stadium, in good agreement with ray numerical simulations. We develop an analytical geometrical optics model which permits to account for the main observed features. Wave numerical calculations confirm the results.
Stem cell factor as a novel diagnostic marker for early malignant germ cells (2008)

Carcinoma in situ (CIS) of the testis is the pre-invasive stage of type II testicular germ cell tumours (TGCTs) of adolescents and adults. These tumours are the most frequently diagnosed cancer in Caucasian adolescents and young adults. In dysgenetic gonads, the precursor of type II GCTs can be either CIS or a lesion known as gonadoblastoma (GB). CIS/GB originates from a primordial germ cell (PGC)/gonocyte, ie an embryonic cell. CIS can be cured by local low-dose irradiation, with limited side effects on hormonal function. Therefore, strategies for early diagnosis of CIS are essential. Various markers are informative to diagnose CIS in adult testis by immunohistochemistry, including c-KIT, PLAP, AP-2gamma, NANOG, and POU5F1 (OCT3/4). OCT3/4 is the most informative and consistent in presence and expression level, resulting in intense nuclear staining. In the case of maturational delay of germ cells, frequently present in gonads of individuals at risk for type II (T)GCTs, use of these markers can result in overdiagnosis of malignant germ cells. This demonstrates the need for a more specific diagnostic marker to distinguish malignant germ cells from germ cells showing maturation delay. Here we report the novel finding that immunohistochemical detection of stem cell factor (SCF), the c-KIT ligand, is informative in this context. This was demonstrated in over 400 cases of normal (fetal, neonatal, infantile, and adult) and pathological gonads, as well as TGCT-derived cell lines, specifically in cases of CIS and GB. Both membrane-bound and soluble SCF were expressed, suggestive of an autocrine loop. SCF immunohistochemistry can be a valuable diagnostic tool, in addition to OCT3/4, to screen for precursor lesions of TGCTs, especially in patients with germ cell maturation delay.
Tumor Necrosis Factor Is Involved in the Appearance of Interleukin-1 Receptor Antagonist in Endotoxemia (1994)

To assess the role of tumor necrosis factor (TNF) in the appearance of interleukin-1 receptor antagonist (IL-1RA) in endotoxemia, 4 healthy humans were studied after a bolus intravenous injection of recombinant human TNF (50 micrograms/m2). In addition, 8 healthy chimpanzees were investigated after a bolus intravenous injection of Escherichia coli endotoxin (4 ng/kg) with (n = 4) or without (n = 4) a simultaneous intravenous injection of a monoclonal anti-TNF antibody (15 mg/kg). TNF induced a pronounced rise in IL-1RA concentrations, becoming apparent after 1 h and peaking after 3 h (P < .05). The rise in IL-1RA after administration of endotoxin started 2 h later. Neutralization of the early endotoxin-induced TNF activity by anti-TNF caused a marked reduction in IL-1RA concentrations (P < .05). These results indicate that TNF is an intermediate factor in IL-1RA release in endotoxemia.
Infectious complications in patients receiving autologous CD34‐selected hematopoietic stem cell transplantation for severe autoimmune diseases (2009)

Long-term analysis of infectious complication after high-dose immunosuppressive therapy with CD34-selected autologous hematopoietic stem cell transplantation for patients with severe autoimmune diseases (AD) was performed. Theoretically, CD34 selection can reduce the risk of reinfusion of autoreactive lymphocytes. However, it is also associated with a significant reduction in T cells, natural killer cells, and monocytes, which in turn may compromise immune reconstitution, thereby increasing the risk of infection. Moreover, AD compromises host immunity and causes organ damage resulting in dysfunction of the cutaneous or mucosal barrier. In this study, the incidence rate of infections is reported in 14 patients who underwent high-dose (200 mg/kg) cyclophosphamide therapy followed by reinfusion of CD34-selected autologous peripheral blood stem cells. Bacterial complication occurred in 3 of 14 (21%) patients. Cytomegalovirus reactivation and adenovirus hemorrhagic cystitis were observed in 9 (64%) and 2 (14%) patients, respectively. As for late infectious complications, 7 patients (50%) developed dermatomal varicella zoster virus infection. No infection-related mortality was seen in this case series. Because the risk for infections approaches that seen in allogeneic transplant recipients, infection surveillance, diagnostic workup, and prophylactic strategies similar to those applicable to allogeneic recipients are warranted.
CCDC 725284: Experimental Crystal Structure Determination (2010)

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Highly Efficient Graphene‐Based Ternary Composite Catalyst with Polydopamine Layer and Copper Nanoparticles (2013)

A synergistically integrated graphene-based ternary composite (rG-Cu) consisting of uniform natural polydopamine (Pdop)-functionalized graphene sheets (Dop-rG) and well-dispersed Cu nanoparticles (NPs) has been developed. By a one-step reduction and modification of graphene oxide with dopamine, water-dispersible Dop-rG was first prepared. Cu NPs were then incorporated homogeneously onto Dop-rG by a simple solution route leading to activated rG-Cu, which showed an ultrahigh catalytic activity and good reusability for catalytic reductions of different types of dyes, including methylene blue and azo-based acid and reactive dyes. It took only 30 s for complete reduction of methylene blue. In addition to the main action of the catalytically active component of the well-dispersed Cu NPs, the uniform adhesive Pdop layer and graphene base with large surface area and superior electron-transfer capacity are also believed to assist synergistically the catalytic reduction. The work has opened up a new avenue for synthesis of a graphene-based ternary composite with extraordinary catalytic activity for practical applications in addressing environmental protection issues.
Supplementary Figure 2 from Hepatocyte Nuclear Factor-4α Promotes Gut Neoplasia in Mice and Protects against the Production of Reactive Oxygen Species (2023)

Supplementary Figure 2 from Hepatocyte Nuclear Factor-4α Promotes Gut Neoplasia in Mice and Protects against the Production of Reactive Oxygen Species
A 3.8 GHz 153 Mb SRAM Design With Dynamic Stability Enhancement and Leakage Reduction in 45 nm High-k Metal Gate CMOS Technology (2009)

A high-performance low-power 153 Mb SRAM is developed in 45 nm high-k Metal Gate technology. Dynamic SRAM PMOS forward-body-bias (FBB) and Active-Controlled SRAM VCC in Sleep are integrated in the design to lower Active-VCCmin and Standby Leakage, respectively. FBB improves the Active-VCCmin by up to 75 mV, and Active-Controlled SRAM VCC distribution tightened by 100 mV, both of which result in further power reduction. A 0.346 mum <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> 6T-SRAM bit-cell is used which is optimized for VCCmin, performance, leakage and area. The design operates at high-speed over a wide voltage range, and has a maximum frequency of 3.8 GHz at 1.1 V. The 16 KB Subarray was also used as the building block in on-die 6 MB Cache for Intel Core 2 Duo CPU in 45 nm technology.
Subjective Testing of Compression Drivers (2005)

A subjective test was devised and performed in order to assess the factors that influence the perception of sound emitted by compression drivers. A musical passage was high-pass filtered and played through three compression drivers of similar characteristics, loaded by a plane-wave tube, and recorded. To obtain different levels of nonlinear distortion, the passage was played at three different voltage levels on each driver. The resulting sound files were recombined with the low-pass-filtered portion, yielding nine complete sound pieces whose only differences from the original passage were caused by the drivers' behavior. The nine stimuli were then presented, in a double-blind test, to 27 subjects, who were asked to rate audible differences when compared to the original passage. Analysis of the results shows that the differences in frequency response between drivers are statistically significant, whereas differences in playing level, and therefore nonlinear distortion, were not significant. This unexpected result implies that nonlinear distortion is not audible under these test conditions, and it leads to important conclusions regarding the design objectives of compression drivers.
Dramatic response to entrectinib in a patient with malignant peripheral nerve sheath tumor harboring novel <i>SNRNP70‐NTRK3</i> fusion gene (2022)

Neurotropic tropomyosin receptor kinase (NTRK) gene rearrangements have been reported in limited cases of sarcomas; however, to date, there has been only one report of such rearrangements in malignant peripheral nerve sheath tumors (MPNSTs). Herein, we describe a 51-year-old male patient with a buttock tumor arising from the sciatic nerve, which was diagnosed as MPNST with positive S-100 staining, negative SOX10 staining, and loss of trimethylation at lysine 27 of histone H3 (H3K27me3) confirmed by immunohistochemistry. Soon after the resection of the primary tumor, the patient was found to have pulmonary and lymph node metastases. Chemotherapy with eribulin and trabectedin showed limited effects. However, the patient responded rapidly to pazopanib, but severe side effects caused discontinuation of the treatment. RNA panel testing revealed a novel fusion gene between Small Nuclear Ribonucleoprotein U1 Subunit 70 (SNRNP70) gene and NTRK3 gene. Furthermore, loss of NF1, SUZ12, and CDKN2A genes was confirmed by DNA panel testing, which is compatible with a histological diagnosis of MPNST. SNRNP70 possesses a coiled-coiled domain and seems to induce constitutive activation of NTRK3 through dimerization. In fact, immunohistochemistry revealed diffuse staining of pan-TRK within tumor cells. Treatment with entrectinib, which is an NTRK inhibitor, showed a quick and durable response for 10 months. Although NTRK rearrangements are very rare in MPNST, this case highlights the importance of genetic testing in MPNST, especially using an RNA panel for the detection of rare fusion genes.
Photodynamic therapy on ocular neovascularization (1995)

The efficacy of photodynamic therapy using porphymer sodium (PF) and newly-developed chlorin derivative (ATX-S10) for occlusion of corneal new vessels has been evaluated experimentally. Twenty-six albino rabbits were treated with an intravenous injection of 2mg/kg of PF, followed by argon green laser (514nm) irradiation to the corneal new vessels with three varieties of energy at 24, 48, 72 and 96 hours after the injection, respectively. In another group of 4 rabbits, diode laser (672nm) was irradiated with the energy from 43J/cm2 to 323J/cm2 at 4 and 6 hours after the administration of 12mg/kg of ATX-S10, respectively. The closure of corneal new vesseles was confirmed by slit-lamp examination, fluorescein angiography and light microscopic study. With PF, irradiation with exposure energy of 19.1J/cm2 during 24 and 72 hours after the administration was estimated to be suitable for the treatment, because new vesseles were closed with a mild damage of the surrounding normal tissue such as the iris. Exposure energy more than 38.2J/cm2 was thought to be excess since surrounding normal tissue was heavily damaged. With ATX-S10, selective closure of corneal new vessels were obtained by irradiation with exposure energy of 86.1/cm2 and 258J/cm2 at 4 and 6 hours after the administration, respectively. In control groups which received laser irradiation without photosensitizer administration, new vessels were not closed. These results suggests PF and ATX-S10 used here are new therapeutic agents for the treatment of corneal neovascularization. Especially, ATX-S10 is a promising new photosensitizer since it has more rapid elimination from the body and less skin phototoxicity than PF.
Control of membrane function : short-term and long-term : proceedings of the 13th International Conference on Biological Membranes held at Crans-sur-Sierre, Switzerland, June 19-22, 1989 (1990)

Preface. Dedication. Contributors. Acknowledgements. Signal Transduction . Signalling through phospholipid breakdown (J.H. Exton). Receptor-mediated activation of phospholipase A2 (J. Axelrod). Protein phosphorylation in the nervous system (R.L. Huganir). Alpha-adrenergic inhibition of N-type calcium channels and neurotransmitter release in sympathetic neurones (D. Lipscombe, S. Kongsamut and R.W. Tsien). Release of vasoactive intestinal peptide (VIP) in mouse neocortex: Ca 2+ -channel subtypes and involvement of arachidonic acid metabolites (J-L. Marin and P.J. Magistretti). The effects of calcium channel agonists and antagonists on the binding of [ 3 H] nitrendipine to synaptic membrane and postsynaptic density factions isolated from canine cerebral cortex. Evidence for a separate-site model for agonists and antagonists (P. Siekevitz and M. Ledoux). Adaptive changes in signal transduction systems: Molecular mechanisms of opiate addiction in rate locus coeruleus (E.J. Nestler). Does catecholamine-induced sequestration of beat-adrenergic receptors involve endocytosis via the clathrin-coated PIT pathway (J.P. Perkins). The molecular components of the olfactory signal transduction cascade (R.R. Reed, H.A. Bakalyar, P.G. Feinstein and D.T. Jones). The control of photoreceptor sensitivity (T.D. Lamb and V. Torre). Receptor Structure and Function. What the structure of the acetylocholine receptor tells us about the function of the ligand gated ion channel family (R.M. Stroud). Characteristics of acetylcholine receptor-channels stably expressed in fibroblasts (T. Claudio). The structure of the NMDA receptor-channel complex (P. Ascher and J. Johnson). Are receptor-associated nuclear proteins associated with the earliest effects of steroid hormones? (E-E. Baulieu, N. Binart, F. Cadepond, M-G. Catelli, B. Chambraud, J. Garnier, J-M. Gasc, G. Groyer-Schweizer, M-E. Rafestin-Oblin, C. Radanyi, G. Reduilh, J-M. Renoir and M. Sabbah). Ion Channels. Characteristics of beta-adrenergic-activitated Na-proton transport in red blood cells (R. Motais, U. Scheuring, F. Borgese and F. Garcia-Romeu). Energy profiles for ion permeation in pentameric protein channels: From viruses to receptor channels (G. Eisenman, A. Villarroel, M. Montal and O. Alvarez). The LAC permease of Escherichia coli: A prototype transport protein (P.D. Roepe and H.R. Kaback). Studies on the two inorganic anion transport systems in the red blood cell of the mouse (H. Passow, J. Wendel, E.-M. Gartner, B. Legrum, D. Bartel and S. Lepke). Differential expression and developmental regulation of NA, K-ATPASE isoforms in rat fetal telencephalon organotypic cell cultures (I. Corthesy-Theulaz, B. Rossier and P. Honegger). Longterm Control Mechanisms. Neuronal plasticity: Lectin-induced changes in the membrane properties of cultured Aplysia neurons (I.B. Levitan, G.M. Carrow, D. Dagan, S.S. Lin and M.P. Wilson). Long-term potentiation in the hippocampus (R.C. Malenka, J.A. Kauer, D.J. Perkel and R.A.
A thermo-metallurgical-mechanical model for microstructure evolution in laser-assisted robotic roller forming of ultrahigh strength martensitic steel (2023)

Laser-assisted robotic roller forming (LRRF) apparatus and process were developed to bend a plate to form a straight channel for ultrahigh strength steel MS1300. Since the thermal processing during the roller forming impacts the microstructure and mechanical behavior of the steel, an integrated thermo-metallurgical-mechanical finite element simulation considering the heat source, phase transformation and material constitutive models was established. A rectangular laser source was devised to homogenize the temperature around the bending corner and a new surface heat source model was proposed and validated. The phase transformation model accounting for the austenitization process, austenite decomposition and tempering was embedded in the finite element model through self-developed user subroutines. The predicted microstructure evolution and the phase distribution were consistent with experimental microstructure characterization. More specifically, it is found that tempering dominates at the inner layer of the bend, resulting in two different phases, i.e., the original and tempered martensitic phases after the LRRF process. The outer layer of the bend, however, goes through austenitization, quenching, and tempering processes, resulting in a combination of fresh martensite, a small amount of tempered martensite and retained austenite phases.
CHAPTER 3. RNA Polymerase as a Torsional Motor (2021)

As a torsional motor, RNA polymerase (RNAP) generates torque and drives DNA into supercoiled forms. Torque and DNA supercoiling, in turn, play important roles in regulating transcription. The diverse and widespread effects of torsion on transcription indicate that torsion itself may serve as an important point of regulation by the cell. Although biologically important, the torsional characteristics of RNAPs and their regulation have, until recently, remained poorly understood due to the technical challenges in directly measuring real-time torque in biomolecular systems. In this chapter, we describe how transcription-generated torque has been measured, enabling the characterization of RNAP's torque generation characteristics. Additionally, we focus on recent studies demonstrating that RNAP's torque generation capacity can be regulated by a transcription factor, and discuss the biological implications of these new discoveries.
Root Growth and Organogenesis in Thidiazuron-treated Ginseng (Panax quinquefolium L.) (1996)

Ginseng is an herbaceous perennial that grows in the understorey of deciduous hardwood forests and is also cultivated for its highly valued root. The primary method of propagation of ginseng is by seed which requires the breaking of dormancy by stratification, a process which takes 18–24 months. Investigation of factors controlling the growth and development of ginseng plants is a prerequisite to the development of a more efficient system of ginseng propagation. We have recently modulated the morphogenetic potential of geranium roots and stimulated de novo development of shoots and embryo-like structures which later formed whole plants using thidiazuron (TDZ). Our objective was to investigate the morphological changes in seedling and mature ginseng plants induced by TDZ, particularly in relation to root and shoot morphogenesis and economic yield. Applications of TDZ (0.22 and 2.20 ppm), either as foliar sprays or soil watering to greenhouse-grown seedlings over 18 weeks (2 weeks after sowing to 20 weeks when plants were harvested) induced similar effects. These responses included increased stem length and diameter, and shoot and root weight (economic yield). Single foliar applications of TDZ at 62.5 and 125 ppm to 3-year-old field-grown ginseng plants 3 months before harvest increased root biomass (economic yield) by 19% to 23%. Roots of TDZ-treated seedlings and 3-year-old field-grown plants developed thickened secondary roots on the upper part of the taproot. The root-like structure of these secondary roots was confirmed by histology. In addition, TDZ treatments induced adventitious buds on the shoulder of 3-year-old roots. These buds developed into shoots to give multi-stem plants following a period of dormancy, which was overcome with GA 3 (gibberellic acid) treatment before planting.