gebhart/patrepeval huggingface dataset:
A phase 3 trial to compare efficacy and safety of lenvatinib in combination with everolimus or pembrolizumab versus sunitinib alone in first-line treatment of patients with metastatic renal cell carcinoma. (2018)

TPS706 Background: Lenvatinib (LEN) is a multikinase inhibitor of vascular endothelial growth factor (VEGF) receptor 1–3, fibroblast growth factor receptor 1–4, platelet-derived growth factor receptor alpha, and RET and KIT. Based on a phase 2 study (Motzer et al. Lancet Oncol. 2015), LEN was approved in combination with everolimus (EVE) for the treatment of metastatic renal cell carcinoma (RCC) following 1 prior VEGF-targeted therapy. A phase 1b/2 study of LEN in combination with pembrolizumab (PEM) in patients (pts) with RCC LEN is also underway. We report the design of a multicenter, open-label, phase 3 trial of LEN plus EVE or PEM vs sunitinib (SUN; a standard therapy for RCC) as first-line treatment for advanced RCC. Methods: Pts aged ≥ 18 years with confirmed advanced RCC diagnosis, ≥ 1 measurable lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1, Karnofsky Performance Status ≥ 70, controlled blood pressure, and adequate blood coagulation, renal, hepatic, and bone marrow function are eligible. Pts will be randomized 1:1:1 to receive LEN 18 mg/d + EVE 5 mg/d, LEN 20 mg/d + PEM 200 mg every 3 wks, or SUN 50 mg/d (on a schedule of 4 wks on treatment followed by 2 wks off) until disease progression, unacceptable toxicity, withdrawal of consent, or study end. The primary endpoint is to show superiority of LEN+EVE or LEN+PEM over single-agent SUN as first-line treatment for advanced RCC in improving progression-free survival (PFS). Secondary endpoints include comparison of objective response rate, overall survival, PFS on next-line therapy, health-related quality of life, and safety and tolerability in pts receiving LEN+EVE or LEN+PEM vs SUN. Exploratory endpoints include PFS in the LEN+PEM arm using immune-related RECIST, comparison of duration of response, disease control rate, and clinical benefit rate in pts treated with LEN+EVE or LEN+PEM vs SUN, and analysis of the relationship between blood biomarkers and outcome. No interim analysis is planned for efficacy or futility. Enrollment of 735 pts is planned to achieve 90% power at 2-sided α = 0.05 to detect a difference in ≥ 1 of the primary comparisons. Clinical trial information: NCT02811861.
Smart, portable, miniature, static, broadband, optical interferometers and measurements (2014)

Optical interferometry is a well-known, highly regarded and powerful measurement technique that is used in many forms to perform a very wide range of measurements. Applications of interferometry range from source characterisation to material characterisation; from OCT to photonic sensing; and from space weather monitoring to gravitational wave detection efforts. In this work, we report this powerful measurement tool in its form as a PIE instrument that is based on the Young's interferometer configuration. We report several metrology and FT-spectroscopy measurements using this miniature, portable, static, broadband interferometer configuration that includes both optical fiber circuits and optical waveguide circuits. Using these simple and powerful interferometer configurations, we report sub-nanometer spectral resolutions, picometer detection of wavelength changes, high resolution measurements of group velocity dispersion and attosecond measurements of delay change.
Unsupervised Transductive Domain Adaptation (2016)

Supervised learning with large scale labeled datasets and deep layered models has made a paradigm shift in diverse areas in learning and recognition. However, this approach still suffers generalization issues under the presence of a domain shift between the training and the test data distribution. In this regard, unsupervised domain adaptation algorithms have been proposed to directly address the domain shift problem. In this paper, we approach the problem from a transductive perspective. We incorporate the domain shift and the transductive target inference into our framework by jointly solving for an asymmetric similarity metric and the optimal transductive target label assignment. We also show that our model can easily be extended for deep feature learning in order to learn features which are discriminative in the target domain. Our experiments show that the proposed method significantly outperforms state-of-the-art algorithms in both object recognition and digit classification experiments by a large margin.
Feature selection for real-time tracking (2006)

We address the problem of selecting features to improve automated video tracking of targets that undergo multiple mutual occlusions. As targets are occluded, different feature subsets and combinations of those features are effective in identifying the target and improving tracking performance. We use Combinatorial Fusion Analysis to develop a metric to dynamically select which subset of features will produce the most accurate tracking. In particular we show that the combination of a pair of features A and B will improve the accuracy only if (a) A and B have relative high performance, and (b) A and B are diverse. We present experimental results to illustrate the performance of the proposed metric.
Light-quark and gluon jet discrimination in $$pp$$ p p collisions at $$\sqrt{s}=7\mathrm {\ TeV}$$ s = 7 TeV with the ATLAS detector (2014)

A likelihood-based discriminant for the identification of quark- and gluon-initiated jets is built and validated using 4.7 fb[Formula: see text] of proton-proton collision data at [Formula: see text] [Formula: see text] collected with the ATLAS detector at the LHC. Data samples with enriched quark or gluon content are used in the construction and validation of templates of jet properties that are the input to the likelihood-based discriminant. The discriminating power of the jet tagger is established in both data and Monte Carlo samples within a systematic uncertainty of [Formula: see text] 10-20 %. In data, light-quark jets can be tagged with an efficiency of [Formula: see text] while achieving a gluon-jet mis-tag rate of [Formula: see text] in a [Formula: see text] range between [Formula: see text] and [Formula: see text] for jets in the acceptance of the tracker. The rejection of gluon-jets found in the data is significantly below what is attainable using a Pythia 6 Monte Carlo simulation, where gluon-jet mis-tag rates of 10 % can be reached for a 50 % selection efficiency of light-quark jets using the same jet properties.
Pseudoadiabatic catalytic reactor operation for the conversion of synthesis gas into hydrocarbons (gasoline range) (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPseudoadiabatic catalytic reactor operation for the conversion of synthesis gas into hydrocarbons (gasoline range)Francois Simard, Arnaud Mahay, Alberto Ravella, Gilles Jean, and Hugo De LasaCite this: Ind. Eng. Chem. Res. 1991, 30, 7, 1448–1455Publication Date (Print):July 1, 1991Publication History Published online1 May 2002Published inissue 1 July 1991https://pubs.acs.org/doi/10.1021/ie00055a008https://doi.org/10.1021/ie00055a008research-articleACS PublicationsRequest reuse permissionsArticle Views187Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Optimal Detection of Symmetric Mixed Quantum States (2004)

We develop a sufficient condition for the least-squares measurement (LSM), or the square-root measurement, to minimize the probability of a detection error when distinguishing between a collection of mixed quantum states. Using this condition we derive the optimal measurement for state sets with a broad class of symmetries. We first consider geometrically uniform (GU) state sets with a possibly non-Abelian generating group, and show that if the generator satisfies a weighted norm constraint, then the LSM is optimal. In particular, for pure-state GU ensembles, the LSM is shown to be optimal. For arbitrary GU state sets we show that the optimal measurement operators are GU with generator that can be computed very efficiently in polynomial time, within any desired accuracy. We then consider compound GU (CGU) state sets which consist of subsets that are GU. When the generators satisfy a certain constraint, the LSM is again optimal. For arbitrary CGU state sets, the optimal measurement operators are shown to be CGU with generators that can be computed efficiently in polynomial time.
ChemInform Abstract: Ruddlesden‐Popper Lnn+1NinO3n+1 Nickelates: Structure and Properties (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Coupled stochastic simulation of the chain length and particle size distribution in miniemulsion radical copolymerization of styrene and <i>N</i>-vinylcaprolactam (2019)

Kinetic Monte Carlo modeling is applied for the coupled simulation of the chain length and particle size distribution in isothermal batch miniemulsion copolymerization of styrene and <italic>N</italic>-vinylcaprolactam.
Scanning electron microscope observation of dislocations in semiconductor and metal materials (2010)

Scanning electron microscope (SEM) image contrasts have been investigated for dislocations in semiconductor and metal materials. It is revealed that single dislocations can be observed in a high contrast in SEM images formed by backscattered electrons (BSE) under the condition of a normal configuration of SEM. The BSE images of dislocations were compared with those of the transmission electron microscope and scanning transmission electron microscope (STEM) and the dependence of BSE image contrast on the tilting of specimen was examined to discuss the origin of image contrast. From the experimental results, it is concluded that the BSE images of single dislocations are attributed to the diffraction effect and related with high-angle dark-field images of STEM.
Functional involvement of Daxx in gp130‐mediated cell growth and survival in BaF3 cells (2010)

Death domain-associated protein (Daxx) is a multifunctional protein that modulates both cell death and transcription. Several recent studies have indicated that Daxx is a mediator of lymphocyte death and/or growth suppression, although the detailed mechanism is unclear. Previously, we reported that Daxx suppresses IL-6 family cytokine-induced gene expression by interacting with STAT3. STAT3 is important for the growth and survival of lymphocytes; therefore, we here examined the role of Daxx in the gp130/STAT3-dependent cell growth/survival signals. We found that Daxx suppresses the gp130/STAT3-dependent cell growth and that Daxx endogenously interacts with STAT3 and inhibits the DNA-binding activity of STAT3. Moreover, small-interfering RNA-mediated knockdown of Daxx enhanced the expression of STAT3-target genes and accelerated the STAT3-mediated cell cycle progression. In addition, knockdown of Daxx-attenuated lactate dehydrogenase leakage from cells, indicating that Daxx positively regulates cell death during gp130/STAT3-mediated cell proliferation. Notably, Daxx specifically suppressed the levels of Bcl2 mRNA and protein, even in cytokine-unstimulated cells, indicating that Daxx regulates Bcl2 expression independently of activated STAT3. These results suggest that Daxx suppresses gp130-mediated cell growth and survival by two independent mechanisms: inhibition of STAT3-induced transcription and down-regulation of Bcl2 expression.
0.7W CW output power from a Green semiconductor disk laser (2006)

We demonstrate 0.7 W cw output power at 520 nm from an intracavity frequency doubled Optically Pumped Semiconductor Disk Laser at room temperature. High beam quality and optical conversion efficiency of 10% has been achieved.
Human Activity Detection Using Smartphones and Maps (2013)

This dissertation provides systems, methods, and algorithms for the detection of human activities from smartphones and maps. Knowledge of automated human activities derived from travelers’ smartphones enables data service innovations where mobile services are created based on patterns related to individuals as well as communities. Some examples of human activities that we propose to derive from travelers’ mobile phones are transportation modes (indoor and outdoor) and street parking status. Using information about individual travelers, the dissertation shows how community patterns such as the parking availability on a street block can be estimated.
Asymmetric Pt(II)-Catalyzed Ene Reactions:  Counterion-Dependent Additive and Diphosphine Electronic Effects<sup>1</sup> (2001)

[reaction: see text]. Catalysis of the glyoxylate-ene reaction by dicationic P2Pt(II) complexes is subject to anion-dependent additive effects. For [((S)-MeOBiphep)Pt](OTf)2 catalysts, acidic phenols such as 3-CF3-C6H3OH or C6F5OH provide substantial rate increases but do not affect the more active SbF6-based catalysts. Enantioselectivity and reactivity also increased with diphosphine basicity, with 4-t-Bu-substituted MeOBiphep ligands yielding the highest enantioselectivities.
Methods—Analyzing Electrochemical Kinetic Parameters in Deep Eutectic Solvents Using an Extended Butler-Volmer Equation (2021)

Deep eutectic solvents (DESs) are promising electrolytes for electrochemical redox reactions, which can be used in redox flow batteries (RFBs). However, in some systems like the Fe 2+/3+ redox reaction in ethaline, traditional Tafel-based kinetic analysis generates unreasonable kinetic parameters (i.e., large anodic/cathodic charge transfer coefficients ( α a , α c ) along with low exchange current densities ( i 0 )). This hinders a comprehensive kinetic and kinetic mechanism study. Here, we perform a detailed investigation of the Tafel analysis using a series of synthetic rotating disk electrode (RDE) data. We find the Tafel analysis only works well when i 0 &lt; 0.57 i lim (limiting current density) in our scenario and leads to abnormal kinetic values once i 0 exceeds this limiting value. Thus, we propose an extended Butler-Volmer (ex-BV) analysis based on modern non-linear fitting techniques to obtain the actual kinetic parameters for such systems. The results show that this method fits the RDE data closely and generates reliable α a , α c and i 0 values, demonstrating that it is a good replacement for traditional Tafel analysis for kinetic studies in high-viscosity electrolytes such as DES systems.
Conceivable difference in the anti‐inflammatory mechanisms of lipocortins 1 and 5 (1993)

Human recombinant lipocortins (LCT) 1 and 5 have been expressed in a yeast secretion vector and purified by ion exchange chromatography. The action of the proteins has been investigated in two models of experimental acute inflammation in the rat: carrageenin induced paw oedema and zymosan induced pleurisy. The effects of the proteins on PGE(2) release in vitro by rat macrophages stimulated with zymosan and on rat neutrophil chemotaxis induced by FMLP have also been assessed. LCT-1 significantly inhibited both paw swelling in carrageenin oedema and leukocyte migration in zymosan pleurisy. Moreover it showed a dose dependent, inhibitory effect on PGE(2) release. Neutrophil chemotaxis was only weakly affected by LCT-1. Conversely LCT-5 did not reduce carrageenin oedema and slightly inhibited PGE(2) release, but showed profound, dose dependent inhibitory activity on leukocyte migration in zymosan pleurisy and on neutrophil chemotaxis. These data suggest that LCT-1 acts mainly by interfering with arachidonic acid metabolism via the inhibition of phospholipase A(2). The anti-inflammatory activity of LCT-5, at variance with LCT-1, may be due to a direct effect on cell motility in addition to the interference with arachidonic acid metabolism.
Data from Local Treatment of a Pediatric Osteosarcoma Model with a 4-1BBL Armed Oncolytic Adenovirus Results in an Antitumor Effect and Leads to Immune Memory (2023)

&lt;div&gt;Abstract&lt;p&gt;Osteosarcoma is an aggressive bone tumor occurring primarily in pediatric patients. Despite years of intensive research, the outcomes of patients with metastatic disease or those who do not respond to therapy have remained poor and have not changed in the last 30 years. Oncolytic virotherapy is becoming a reality to treat local and metastatic tumors while maintaining a favorable safety profile. Delta-24-ACT is a replicative oncolytic adenovirus engineered to selectively target cancer cells and to potentiate immune responses through expression of the immune costimulatory ligand 4-1BB. This work aimed to assess the antisarcoma effect of Delta-24-ACT. MTS and replication assays were used to quantify the antitumor effects of Delta-24-ACT &lt;i&gt;in vitro&lt;/i&gt; in osteosarcoma human and murine cell lines. Evaluation of the &lt;i&gt;in vivo&lt;/i&gt; antitumor effect and immune response to Delta-24-ACT was performed in immunocompetent mice bearing the orthotopic K7M2 cell line. Immunophenotyping of the tumor microenvironment was characterized by immunohistochemistry and flow cytometry. &lt;i&gt;In vitro&lt;/i&gt;, Delta-24-ACT killed osteosarcoma cells and triggered the production of danger signals. &lt;i&gt;In vivo&lt;/i&gt;, local treatment with Delta-24-ACT led to antitumor effects against both the primary tumor and spontaneous metastases in a murine osteosarcoma model. Viral treatment was safe, with no noted toxicity. Delta-24-ACT significantly increased the median survival time of treated mice. Collectively, our data identify Delta-24-ACT administration as an effective and safe therapeutic strategy for patients with local and metastatic osteosarcoma. These results support clinical translation of this viral immunotherapy approach.&lt;/p&gt;&lt;/div&gt;
Unprecedented imido-bridged binuclear cobalt(III) complex: synthesis and molecular structure of p-[Co2(.mu.-(.mu.2-N:.eta.1-O,O')-imidomalonato)(tren)2](ClO4)3.cntdot.H2O (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTUnprecedented imido-bridged binuclear cobalt(III) complex: synthesis and molecular structure of p-[Co2(.mu.-(.mu.2-N:.eta.1-O,O')-imidomalonato)(tren)2](ClO4)3.cntdot.H2OTakahiko Kojima, Masanobu Hidai, Reiko Kuroda, and Shigenobu YanoCite this: J. Am. Chem. Soc. 1990, 112, 11, 4576–4577Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/ja00167a083https://doi.org/10.1021/ja00167a083research-articleACS PublicationsRequest reuse permissionsArticle Views129Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Grid power quality improvements using grid-coupled hybrid electric vehicles (2006)

Abstract The paper examines the interaction between grid-coupled full hybrid electric vehicles (HEV) and the grid. The interaction allows the hybrid vehicle to travel a significant part of the time in all-electric mode. On the other hand, the grid coupling allows the grid to use the hybrid car as a controllable load and energy storage facility, enabling a higher penetration of variable generation units, such as renewable sources based on wind and photovoltaic cells. Experiments with a battery, grid connection and induction machine prove the feasibility of these grid-coupled hybrid electric vehicles. 1 Introduction The batteries currently used in HEVs are expensive and heavy, leading to a low specific energy content. Through the rapid development of batteries the cost per kWh diminishes while the specific energy content rises. As a consequence, larger amounts of energy can be stored in an economic way for the electric propulsion of HEVs and larger distances can be travelled in an all-electric “emission free” mode. An estimated 85 % of fuel (not energy) savings can be achieved if the vehicle has an all-electric driving range of 100 km [6]. In order to achieve this kind of fuel savings, the battery needs to be charged with electrical energy from the grid, as opposed to the current practice where a combustion engine powers an on-board electric generator to produce electric energy. The only requirement to make this happen is a grid coupling. This grid coupling makes a variety of interactions possible between a fleet of HEVs and the grid [1,5]. From the perspective of the hybrid fleet, the grid coupling enables a lower energy cost and a reduction in environmental pollution, on condition that the electric energy production itself is environmently friendly. From the perspective of the grid the fleet of hybrid electric vehicles can act as a controllable load to smooth grid load. Power electronics for the grid coupling, can provide reactive power to enhance the power factor of the installation and can be used as an active filter to eliminate harmonics. By injecting electrical energy in the grid, the HEV can be used as reserve power unit to set off the loss of a power plant, as replacement for peak power units, as part of a microgrid or as stand-alone mobile generator. Other possibilities such as peak-shaving are possible from a technical point of view, but lack the necessary economical feasibility.
EGFR mutation up-regulates EGR1 expression through the ERK pathway. (2009)

Mutant EGFR constitutively up-regulates EGR1 through the ERK pathway, and its expression is correlated with EGFR signal activation. Findings provide an insight into a target gene of mutant EGFR and further improve the understanding of the oncogenic properties of EGFR.