gebhart/patrepeval huggingface dataset:
Activation of an Open Shell, Carbyne-Bridged Diiron Complex Toward Binding of Dinitrogen (2020)

Binding of N<sub>2</sub> by nitrogenase requires a reductive activation of the FeMo-cofactor, but the precise structure and atomic composition of FeMoco in its activated form is not well understood. However, recent crystallographic studies suggest that N<sub>2</sub> reduction may occur at a carbon-bridged diiron subunit of FeMoco. Toward modeling the activation of a Fe-(μ-C)-Fe site toward N<sub>2</sub> binding, we synthesized a new dinucleating, hexaphosphine ligand derived from a 2,6-disubstituted toluene platform. Activation of the central methyl group of the ligand affords the diiron μ-carbyne complex (P<sub>6</sub>ArC)Fe<sub>2</sub>(μ-H) featuring a biologically relevant Fe(μ-carbyne)(μ-H)Fe motif. SQUID magnetometry, Mössbauer spectroscopy, and DFT calculations reveal that (P<sub>6</sub>ArC)Fe<sub>2</sub>(μ-H) has a well-isolated <i>S</i> = 1 ground state, distinguishing it from all other diiron μ-carbyne complexes which are diamagnetic. Upon the addition of sources of H<sup>+</sup>/e<sup>-</sup> (H<sub>2</sub>, TEMPO-H or HCl), (P<sub>6</sub>ArC)Fe<sub>2</sub>(μ-H) is activated toward N<sub>2</sub> binding, with concomitant protonation of the carbyne ligand. Although reaction with H<sub>2</sub> ultimately leads to complete protonation of the carbyne moiety, mechanistic investigations indicate that formation of a single C-H bond, with concomitant cleavage of one Fe-C bond, generates an iron-carbene intermediate capable of coordinating N<sub>2</sub>.
LIBRA: Client Initiated Algorithm for Load Balancing Using Work Stealing Mechanism (2009)

We design and evaluate a hybrid load balancing policy, which selects effective node sets in the stage of static load balancing to lower the odds of selecting ineffective nodes and makes use of the stage of dynamic load balancing. When a node status changes, a new substitute can be located in the shortest time to maintain the execution performance of the system. The algorithm deals with an effective methodology to generate an optimum output by making efficient use of available resources in MIMD architectures.
Conditional-mean initialization using neighboring objects in deformable model segmentation (2008)

Most model-based segmentation methods find a target object in a new image by constructing an objective function and optimizing it using a standard minimization algorithm. In general, the objective function has two penalty terms: 1) for deforming a template model and 2) for mismatch between the trained image intensities relative to the template model and the observed image intensities relative to the deformed template model in the target image. While it is difficult to establish an objective function with a global minimum at the desired segmentation result, even such an objective function is typically non-convex due to the complexity of the intensity patterns and the many structures surrounding the target object. Thus, it is critical that the optimization starts at a point close to the global minimum of the objective function in deformable model-based segmentation framework. For a segmentation method in maximum a posteriori framework a good objective function can be obtained by learning the probability distributions of the population shape deformations and their associated image intensities because each penalty term can be simplified to a squared function of some distance metric defined in the shape space. The mean shape and intensities of the learned probability distributions also provide a good initialization for segmentation. However, a major concern in estimating the shape prior is the stability of the estimated shape distributions from given training samples because the feature space of a shape model is usually very high
Plasma fibronectin supports hemostasis and regulates thrombosis (2014)

Plasma fibronectin (pFn) has long been suspected to be involved in hemostasis; however, direct evidence has been lacking. Here, we demonstrated that pFn is vital to control bleeding in fibrinogen-deficient mice and in WT mice given anticoagulants. At the site of vessel injury, pFn was rapidly deposited and initiated hemostasis, even before platelet accumulation, which is considered the first wave of hemostasis. This pFn deposition was independent of fibrinogen, von Willebrand factor, β3 integrin, and platelets. Confocal and scanning electron microscopy revealed pFn integration into fibrin, which increased fibrin fiber diameter and enhanced the mechanical strength of clots, as determined by thromboelastography. Interestingly, pFn promoted platelet aggregation when linked with fibrin but inhibited this process when fibrin was absent. Therefore, pFn may gradually switch from supporting hemostasis to inhibiting thrombosis and vessel occlusion following the fibrin gradient that decreases farther from the injured endothelium. Our data indicate that pFn is a supportive factor in hemostasis, which is vital under both genetic and therapeutic conditions of coagulation deficiency. By interacting with fibrin and platelet β3 integrin, pFn plays a self-limiting regulatory role in thrombosis, suggesting pFn transfusion may be a potential therapy for bleeding disorders, particularly in association with anticoagulant therapy.
Identification of Human H1N2 and Human-Swine Reassortant H1N2 and H1N1 Influenza A Viruses among Pigs in Ontario, Canada (2003 to 2005) (2006)

Since 2003, three novel genotypes of H1 influenza viruses have been recovered from Canadian pigs, including a wholly human H1N2 virus and human-swine reassortants. These isolates demonstrate that human-lineage H1N2 viruses are infectious for pigs and that viruses with a human PB1/swine PA/swine PB2 polymerase complex can replicate in pigs.
Eight Channels of Passive Wireless SAW Temperature Sensors for Specific Low Power Wireless Station (2021)

This paper reports multiple channels of surface acoustic wave (SAW) sensors. We realized by providing reflectors with different positions in the SAW propagation delay line for eight channels of the passive wireless SAW temperature sensors specified low-power radio station.
Antiviral Drug Discovery Strategy Using Combinatorial Libraries of Structurally Constrained Peptides (2004)

We have developed a new strategy for antiviral peptide discovery by using lyssaviruses (rabies virus and rabies-related viruses) as models. Based on the mimicry of natural bioactive peptides, two genetically encoded combinatorial peptide libraries composed of intrinsically constrained peptides (coactamers) were designed. Proteomic knowledge concerning the functional network of interactions in the lyssavirus transcription-replication complex highlights the phosphoprotein (P) as a prime target for inhibitors of viral replication. We present an integrated, sequential drug discovery process for selection of peptides with antiviral activity directed against the P. Our approach combines (i). an exhaustive two-hybrid selection of peptides binding two phylogenetically divergent lyssavirus P's, (ii). a functional analysis of protein interaction inhibition in a viral reverse genetic assay, coupled with a physical analysis of viral nucleoprotein-P complex by protein chip mass spectrometry, and (iii). an assay for inhibition of lyssavirus infection in mammalian cells. The validity of this strategy was demonstrated by the identification of four peptides exhibiting an efficient antiviral activity. Our work highlights the importance of P as a target in anti-rabies virus drug discovery. Furthermore, the screening strategy and the coactamer libraries presented in this report could be considered, respectively, a general target validation strategy and a potential source of biologically active peptides which could also help to design pharmacologically active peptide-mimicking molecules. The strategy described here is easily applicable to other pathogens.
A Recessive Mutant, Pale Brown Eye, and a Cytoplasmic Deleterious Effect on Viability in Anopheles Leucosphyrus (Diptera: Culicidae)1 (1984)

An eye color mutant, Pale brown eye (p), was found in a Sarawak (Malaysia) line of Anopheles leucosphyrus, an important vector of human malaria in that area. The mutant allele is recessive, inherited independently of sex, and is expressed in larval and pupal stages. In the line from which the mutant was derived, there was reduced viability. It was not related to the p mutant or sex, but to the cytoplasm of the line itself.
A Framework for Unified Spectrum Management (USM) in Heterogeneous Wireless Networks (2007)

In the information age, spectrum is a valuable natural resource. Currently, there is a great deal of ongoing research into architectures for spectrum (or more generally, radio resource) management for next generation wireless communications systems. This article proposes a framework for unified spectrum management (USM), where both licensed and license-exempt bands are managed by a hierarchical band management method. An outline for developing the required entities in this architecture is introduced, as well as the protocols that are required for USM operation. We also discuss spatial and temporal coordination of resource usage in such a heterogeneous wireless environment. Finally, a number of open research issues for future study are outlined.
The fluid mechanics of the aortic valve (1969)

The closure mechanism of the human aortic valve is investigated experimentally with a rigid-walled model placed in a pulsatile water-tunnel. It is shown that the valve is controlled by a fluid feed-back system incorporating a stagnation point at the downstream end of each sinus and a trapped vortex within it, and that threequarters of the valve's closure is accomplished during forward flow, requiring only very little reversed flow to seal it. The experiments are complemented by solutions of the inviscid-flow equations, based on a Hill spherical vortex model.
Celecoxib extends C. elegans lifespan via inhibition of insulin-like signaling but not cyclooxygenase-2 activity (2011)

One goal of aging research is to develop interventions that combat age-related illnesses and slow aging. Although numerous mutations have been shown to achieve this in various model organisms, only a handful of chemicals have been identified to slow aging. Here, we report that celecoxib, a nonsteroidal anti-inflammatory drug widely used to treat pain and inflammation, extends Caenorhabditis elegans lifespan and delays the age-associated physiological changes, such as motor activity decline. Celecoxib also delays the progression of age-related proteotoxicity as well as tumor growth in C. elegans. Celecoxib was originally developed as a potent cyclooxygenase-2 (COX-2) inhibitor. However, the result from a structural-activity analysis demonstrated that the antiaging effect of celecoxib might be independent of its COX-2 inhibitory activity, as analogs of celecoxib that lack COX-2 inhibitory activity produce a similar effect on lifespan. Furthermore, we found that celecoxib acts directly on 3'-phosphoinositide-dependent kinase-1, a component of the insulin/IGF-1 signaling cascade to increase lifespan.
Analysis of Totally Reflected Light from Liquid Crystal Cell using Renormalized Ellipsometry (2001)

Standard ellipsometry is usually applied for the evaluation of an optical isotropic system, but it is insufficient to analyze light reflected from an anisotropic system such as a liquid crystal (LC) cell. In order to analyze the light reflected from the LC cell, the standard ellipsometry system combined with the photo elastic modulator was extended to renormalized ellipsometry by introducing the definition of the renormalized reflection coefficients without any modification of the conventional experimental procedure. The experimental results such as the ellipsometric angles versus the rotation angle of the LC cell and the dependence of the ellipsometric angles on the applied electric field were in good agreement with the theoretical results based on renormalized ellipsometry. From these results, it was confirmed that renormalized ellipsometry was quite a useful technique to analyze the totally reflected light from the LC cell.
MetAP2 inhibition reduces food intake and body weight in a ciliopathy mouse model of obesity (2019)

Abstract The ciliopathies Bardet-Biedl Syndrome and Alström Syndrome are genetically inherited pleiotropic disorders with primary clinical features of hyperphagia and obesity. Methionine aminopeptidase 2 inhibitors (MetAP2i) have been shown in preclinical and clinical studies to reduce food intake, body weight, and adiposity. Here we investigated the effects of MetAP2i administration in a mouse model of ciliopathy produced by conditional deletion of the Thm1 gene in adulthood ( Thm1 cko). Thm1 cko mice show decreased hypothalamic pro-opiomelanocortin expression as well as hyperphagia, obesity, metabolic disease and hepatic steatosis. In obese Thm1 cko mice, two-week administration of MetAP2i reduced daily food intake and reduced body weight 17.1% from baseline (vs. 5% reduction for vehicle). This was accompanied with decreased levels of blood glucose, insulin and leptin. Further, MetAP2i reduced gonadal adipose depots and adipocyte size and improved liver morphology. This is the first report of MetAP2i reducing hyperphagia and body weight, and ameliorating metabolic indices in a mouse model of ciliopathy. These results support further investigation of MetAP2 inhibition as a potential therapeutic strategy for ciliary-mediated forms of obesity.
Full Transmission and Reflection of Waves Propagating through a Maze of Disorder (2014)

Thirty years ago, theorists showed that a properly designed combination of incident waves could be fully transmitted through (or reflected by) a disordered medium, based on the existence of propagation channels which are essentially either closed or open (bimodal law). In this Letter, we study elastic waves in a disordered waveguide and present direct experimental evidence of the bimodal law. Full transmission and reflection are achieved. The wave field is monitored by laser interferometry and highlights the interference effects that take place within the scattering medium.
Successful Management of Pediatric Cardiac Contusion With Extracorporeal Membrane Oxygenation (2007)

DeBerry, Brittany B. MD; Lynch, James E. BS, RRT; Chernin, Jill M. RNc; Zwischenberger, Joseph B. MD; Chung, Dai H. MD Author Information
&lt;title&gt;Development of highly active, thermally stable chromophores and polymers for electro-optic applications&lt;/title&gt; (1994)

We have developed two classes of highly efficient and thermally stable nonlinear optical chromophores using fused-thiophene and bithiophene as conjugating units. Experimental studies indicate that the use of fused-thiophene or bithiophene as a (pi) conjugating bridge provides an excellent tradeoff between nonlinearity and thermal stability. In addition to the chromophore developments, we have employed new synthetic methodologies to obtain thermally stable poled polyimides.
Modulation of the Catalytic Behavior of α-Chymotrypsin at Monolayer-Protected Nanoparticle Surfaces (2006)

Amino-acid-functionalized gold clusters modulate the catalytic behavior of alpha-chymotrypsin (ChT) toward cationic, neutral, and anionic substrates. Kinetic studies reveal that the substrate specificity (k(cat)/K(M)) of ChT-nanoparticle complexes increases by approximately 3-fold for the cationic substrate but decreases by 95% for the anionic substrate as compared with that of free ChT, providing enhanced substrate selectivity. Concurrently, the catalytic constants (k(cat)) of ChT show slight augmentation for the cationic substrate and significant attenuation for the anionic substrate in the presence of amino-acid-functionalized nanoparticles. The amino acid monolayer on the nanoparticle is proposed to control both the capture of substrate by the active site and release of product through electrostatic interactions, leading to the observed substrate specificities and catalytic constants.
High π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones: stereocontrolled synthesis of a C24-C32 polyol subunit of rapamycin (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHigh π-face selectivity in anti aldol reactions of E-enol borinates from chiral alkoxymethyl ketones: stereocontrolled synthesis of a C24-C32 polyol subunit of rapamycinIan Paterson and Richard D. TillyerCite this: J. Org. Chem. 1993, 58, 16, 4182–4184Publication Date (Print):July 1, 1993Publication History Published online1 May 2002Published inissue 1 July 1993https://pubs.acs.org/doi/10.1021/jo00068a002https://doi.org/10.1021/jo00068a002research-articleACS PublicationsRequest reuse permissionsArticle Views775Altmetric-Citations48LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Realizing high test quality goals with smart test resource usage (2005)

Growing ASIC design sizes and advanced deep sub-micron technologies require new fault models and more test vectors to meet high test quality goals. To realize these goals within given test resources and cost constraints, new DFT techniques must be used. This paper reports test quality metrics and the test cost of industrial designs for different fault models using three DFT techniques: ATPG for deterministic patterns, Logic BIST for pseudo-random patterns, and EDT for compressed deterministic patterns. It is shown how these techniques can be used to achieve the high quality goals within the test resources currently available for stuck-at tests.
Dietary monosodium glutamate enhances gastric secretion (2009)

Dietary L-glutamate (Glu), an amino acid abundant in many foodstuffs in a free form, is able to modulate physiological functions in the stomach, including secretion and motility. Recently, specific receptors for Glu were identified in the apical membrane of chief cells in the lower region of fundic glands and in the somatostatin-secreting D-cell fraction of the gastric mucosa. This Glu-sensing system in the stomach is linked to activation of the vagal afferents. Among 20 kinds of amino acid, luminal Glu alone activated the vagal afferents in the stomach through a paracrine cascade led by nitric oxide and followed by serotonin (5-HT). In dogs with Pavlov pouches, found that supplementation of an amino acid-rich diet lacking Glu with monosodium Glu (MSG) enhanced the secretion of acid, pepsinogen, and fluid. However, MSG did not affect these secretions induced by a carbohydrate-rich diet and it had no effect on basal secretion when MSG was applied alone without the diet. Enhancement of gastric secretion by MSG was abolished by blockage of the gastric afferents using intra-gastric applied lidocaine. This effect of MSG was due in part to stimulation of 5-HT(3) receptors in the gastric mucosa.
Asymmetry of dynamics at the growing crystal-melt interface (1984)

Dynamic light-scattering measurements on the $b$ face of a salol crystal growing into the melt revealed simultaneous lateral translation dynamics on the crystal surface and slow relaxational dynamics in a thin boundary layer of melt adjacent to the crystal. Analysis of the translational dynamics shows that crystal growth is mediated by highly polygonized screw dislocations. An explanation is suggested for the relaxational dynamics based on the dynamics of nematic liquid crystals.
Structural Maxent Models (2015)

We present a new class of density estimation models, Structural Maxent models, with fea-ture functions selected from a union of possi-bly very complex sub-families and yet benefit-ing from strong learning guarantees. The de-sign of our models is based on a new principle supported by uniform convergence bounds and taking into consideration the complexity of the different sub-families composing the full set of features. We prove new data-dependent learning bounds for our models, expressed in terms of the Rademacher complexities of these sub-families. We also prove a duality theorem, which we use to derive our Structural Maxent algorithm. We give a full description of our algorithm, including the details of its derivation, and report the results of several experiments demonstrating that its per-formance improves on that of existing L1-norm regularized Maxent algorithms. We further sim-ilarly define conditional Structural Maxent mod-els for multi-class classification problems. These are conditional probability models also making use of a union of possibly complex feature sub-families. We prove a duality theorem for these models as well, which reveals their connection with existing binary and multi-class deep boost-ing algorithms.
A methylene-bridged metal-metal bond: neutron diffraction study of (.mu.-CH2)[(.eta.5-C5H5)Rh(CO)]2 at 15 K (1981)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA methylene-bridged metal-metal bond: neutron diffraction study of (.mu.-CH2)[(.eta.5-C5H5)Rh(CO)]2 at 15 KFusao Takusagawa, Alessandro Fumagalli, Thomas F. Koetzle, and Wolfgang A. HerrmannCite this: Inorg. Chem. 1981, 20, 9, 3060–3064Publication Date (Print):September 1, 1981Publication History Published online1 May 2002Published inissue 1 September 1981https://pubs.acs.org/doi/10.1021/ic50223a060https://doi.org/10.1021/ic50223a060research-articleACS PublicationsRequest reuse permissionsArticle Views44Altmetric-Citations14LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts