gebhart/patrepeval huggingface dataset:
A new method of creating minibeam patterns for synchrotron radiation therapy: a feasibility study (2009)

Several synchrotrons around the world are currently developing innovative radiotherapy techniques with the aim of palliating and possibly curing human brain tumors. Amongst them, microbeam radiation therapy (MRT) and, more recently, minibeam radiation therapy (MBRT) have shown promising results. In MBRT the beam thickness ranges from 500 to 700 microm with a separation between two adjacent minibeams of the same value, whilst in MRT the thickness is of the order of 25-50 microm with a distance between adjacent microbeams of the order of 200 microm. An original method has been developed and tested at the ESRF ID17 biomedical beamline to produce the minibeam patterns. It utilizes a specially developed high-energy white-beam chopper whose action is synchronized with the vertical motion of the target moving at constant speed. Each opening of the chopper generates a horizontal beam print. The method described here has the advantage of being simple and reliable, and it allows for an easy control of the patient safety in future clinical trials. To study the feasibility of the method, dosimetric measurements have been performed using Gafchromic HD-810 films and compared with Monte Carlo simulations. The results of this comparison are discussed.
Synthesis and structure of dicarbonyl(.eta.3-indenyl)(.eta.5-indenyl)vanadium(II). An unusual slipped ring in a metal radical (1986)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis and structure of dicarbonyl(.eta.3-indenyl)(.eta.5-indenyl)vanadium(II). An unusual slipped ring in a metal radicalRuth M. Kowaleski, Arnold L. Rheingold, William C. Trogler, and Fred. BasoloCite this: J. Am. Chem. Soc. 1986, 108, 9, 2460–2461Publication Date (Print):April 1, 1986Publication History Published online1 May 2002Published inissue 1 April 1986https://pubs.acs.org/doi/10.1021/ja00269a062https://doi.org/10.1021/ja00269a062research-articleACS PublicationsRequest reuse permissionsArticle Views184Altmetric-Citations65LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Transcatheter Endocardial Ablation: Acute Effects of Direct Current Countershock on Regional Myocardial Blood Flow (1992)

Effect of DC Shock Ablation on Myocardial Blood Flow. Introduction: High energy direct current ablative shocks delivered through endocardial electrode catheters have been used as a treatment for various cardiac arrhythmias including ventricular tachycardia. Frequently, these shocks result in depression of myocardial function, at least transiently. Methods and Results: This study assessed the effect of a 200‐joule direct current shock delivered endocardially to the apex of the heart in ten adult mongrel dogs. Arterial blood pressures were monitored continuously. Myocardial contraction was monitored via two‐dimensional echocardiography. Regional myocardial blood flows were measured using radionuclide labeled microspheres before delivery of the shock, 30 seconds after delivery of the shock, and at 5 and 10 minutes after the shock. The results of the study demonstrated that there was a marked drop in arterial blood pressure immediately after the shock that gradually recovered over a 20‐minute period. Regional myocardial blood flow at the site of catheter ablation was severely depressed immediately after the shock. The degree of myocardial blood flow depression was inversely related to the distance from the site of ablation. At 5–10 minutes after ablation there was a marked hyperemic response in areas that suffered from depressed flow immediately after the shock. Two‐ dimensional echocardiography demonstrated depressed contractile function immediately after the shock with gradual recovery over a 10‐ to 20‐minute period. The catheter shock also generated prominent echo densities within the myocardium surrounding the ablative site. In contrast to the intracavitary echo densities that cleared quickly, the intramyocardial densities cleared much more slowly. Conclusion: The results of the study confirm the clinical observation that human left ventricular function is depressed acutely following a high‐energy ablative shock delivered to the left ventricular endocardium. Our results also demonstrated for the flrst time the effect of such ablative shocks on regional myocardial blood flow. Such depressions of blood flow may help explain the sudden drop in contractile function of the heart. The persistent intramyocardial echoes seen after the shock probably represented generation of intramyocardial bubbles that could obstruct arterial flow as well as disrupt cellular function. ( J Cardiovasc Electrophysiol, Vol. 3, pp. 40–47, February 1992 )
Improved Programming of ICDs (2012)

It can be simply stated that there are only two goals of most therapies: to help patients feel better or to help them live longer (or both). Implantable cardioverter–defibrillators (ICDs) have the potential to achieve both goals, but what distinguishes ICD therapy from medical therapies? Specifically, physicians can determine how an ICD is programmed to deliver therapy, but do we manage programming optimally to improve survival and reduce inappropriate shocks? This is an important question, because cardiovascular implantable electronic device therapy as a class and ICD therapy in particular appear to have inherent characteristics that are distinct in important ways . . .
Termite (2019)

Data-driven analysis is important in virtually every modern organization. Yet, most data is underutilized because it remains locked in silos inside of organizations; large organizations have thousands of databases, and billions of files that are not integrated together in a single, queryable repository. Despite 40+ years of continuous effort by the database community, data integration still remains an open challenge.
Systemic treatment for metastatic castrate resistant prostate cancer: Does seqence matter? (2020)

Our data indicates that sequence of systemic therapy may influence outcomes for mCRPC and that docetaxel should be considered before 2nd generation ADT. Our results support the importance of earlier chemotherapy in the castration resistant state.
Glycosylation of Serum Proteins in Inflammatory Diseases (2008)

Inflammatory diseases are accompanied by numerous changes at the site of inflammation as well as many systemic physiological and biochemical changes. In the past two decades more and more attention is being paid to changes in glycosylation and in this review we describe some of the changes found on main serum proteins (alpha1-acid glycoprotein, immunoglobulin G, immunoglobulin A, transferrin, haptoglobin, alpha2-macroglobulin, C-reactive protein, and others). Molecular background and physiological importance of most of these changes are yet to be discovered, but it is evident that glycosylation plays an important role in the inflammatory response. Maybe the greatest value of these changes currently lays in their potential diagnostic and prognostic usage, either in combination with current diagnostic markers or on their own. However, determining glycan structures is still technically too complex for most clinical laboratories and further efforts have to be made to develop simple analytical tools to study changes in glycosylation.
Association of VEGF Gene Polymorphisms with the Development of Heart Failure in Patients after Myocardial Infarction (2009)

Our data indicate that the -634 polymorphism and its co-inheritance with genotypes of other VEGF polymorphisms might be considered as risk factors playing a role in the clinical outcome of AMI patients.
Supplementary Tables S1-S7 from Genomic Profiling of a Large Set of Diverse Pediatric Cancers Identifies Known and Novel Mutations across Tumor Spectra (2023)

&lt;p&gt;Gene lists for Version 1 of the FoundationOne Assay (S1); Gene lists for Version 2 of the FoundationOne Assay (S2); Gene lists for Version 3 of the FoundationOne Assay (S3); Gene lists for Version 4 of the FoundationOne Assay (S4); Gene lists for Version 5 of the FoundationOne Assay (S5); Distribution of samples across different FoundationOne assays (S6); Filtered variants of unknown significance (S7).&lt;/p&gt;
Methods and Sensors For Functional Genomic Studies of Cell‐Cycle Transitions in Single Cells (2020)

Our understanding of the genetic control mechanisms governing the cell cycle has relied heavily on methods that measure the aggregate state of a population of cells. While instrumental in shaping our fundamental understanding of much of what we know about how the cell cycle is regulated, these approaches also mask the signaling and genetic signatures of rare subpopulations. Quiescent (G 0 ) or very slow dividing (SD) cells are two such related populations. Our data and that of others show that the majority of single clonal MCF7 breast cancer cells cultured at subconfluency can complete a full round of cell division in as little as 24h, however subpopulations within that culture (1–5%) can require over 100h to complete the cell cycle. Moreover, it is not clear how these phenotypes are transferred to daughter cells. Understanding the proteins and networks that control G 0 or SD cells may lead to the identification of new drug targets for aging or tissue regeneration. This study establishes an integrated computational, imaging and molecular pipeline that enables the phenotyping of G 0 or SD cultured cells within a population. We define imaging parameters and open source R scripts to generate and analyze time‐lapse images to track and quantify cell cycle transition in individual cells expressing a genetically encoded cell cycle reporter system (Ki67p‐FUCCI). We report how these cells can be used to identify transcriptomic signatures of G 0 , G 1 and G 2 phase cells within a population. Additionally, we present single‐cell microinjection parameters to optimize single cell transfection by direct injection of mRNA in MCF7 cells with detectable reporter gene expression (GFP) within 5h of microinjection. These findings coupled with the possibility of targeting several hundreds of single cells within a field of view while simultaneously conducting 4 channel time‐lapse microscopy dramatically increase throughput and sensitivity over conventional methods for functional genomics studies to identify new genes that control cell cycle transitions.
EMC Analysis of the Inverting Boost/Buck Converter Topology (2022)

This paper describes the electromagnetic compatibility (EMC) analysis of an inverting buck/boost converter. The inverting buck/boost converter differs from other DC/DC converters, such as the noninverting boost or buck converters, in that one inductor terminal is connected to the ground and not to the input or output of the converter, i.e., neither input nor output is isolated from an EMC perspective. A SPICE model was developed for analyzing the EMC properties of the circuit. Two electromagnetic interference EMI-relevant resonances were observed depending on the state of the switch. Simulations are confirmed with measurements using a circuit designed from discrete components. Further, integrated commercially available converters were analyzed and showed EMC properties that were similar to those of the general model.
Stereocomplex formation between enantiomeric poly(lactic acids). 5. Calorimetric and morphological studies on the stereocomplex formed in acetonitrile solution (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereocomplex formation between enantiomeric poly(lactic acids). 5. Calorimetric and morphological studies on the stereocomplex formed in acetonitrile solutionHideto Tsuji, Suong Hyu Hyon, and Yoshito IkadaCite this: Macromolecules 1992, 25, 11, 2940–2946Publication Date (Print):May 1, 1992Publication History Published online1 May 2002Published inissue 1 May 1992https://pubs.acs.org/doi/10.1021/ma00037a024https://doi.org/10.1021/ma00037a024research-articleACS PublicationsRequest reuse permissionsArticle Views1126Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
71.2: Fabrication and Characterization of Surface Conduction Electron Emitters (2005)

Abstract We have developed a surface conduction electron emitter (SCE) for next‐generation flat displays. PdO thin films (approximately 10 nm) produced by the ink‐jet process were used for forming the surface conduction electron emitter. The films were electroformed and activated while a certain voltage was applied, and an electron emitter with good characteristics was obtained. A current density of approximately 30 mA/cm 2 was attained when an anode voltage of 10 kV was applied. We confirmed operation for 60,000 hours by an acceleration test at a current density of 3 mA/cm 2 . This current density is required for “good brightness” on the surface conduction electron emitter display (SED).
Establishment of infectious HCV virion-producing cells with newly designed full-genome replicon RNA (2011)

Hepatitis C virus (HCV) replicon systems enable in-depth analysis of the life cycle of HCV. However, the previously reported full-genome replicon system is unable to produce authentic virions. On the basis of these results, we constructed newly designed full-genomic replicon RNA, which is composed of the intact 5'-terminal-half RNA extending to the NS2 region flanked by an extra selection marker gene. Huh-7 cells harboring this full-genomic RNA proliferated well under G418 selection and secreted virion-like particles into the supernatant. These particles, which were round and 50 nm in diameter when analyzed by electron microscopy, had a buoyant density of 1.08 g/mL that shifted to 1.19 g/mL after NP-40 treatment; these figures match the putative densities of intact virions and nucleocapsids without envelope. The particles also showed infectivity in a colony-forming assay. This system may offer another option for investigating the life cycle of HCV.
COHERENCE PATTERNS FROM SCALP EEG ARE CONSISTENT WITH MAJOR INTRACORTICAL FIBER PATHWAYS (1996)

Department of Neurology, Neurological Institute of New York, Columbia-Presbyterian Medical Center, New York, NY 10032, USA
Whey Versus Casein Supplementation in Physically Active, Healthy Individuals (2022)

Purpose: Research shows the benefits of whey isolate protein powder and casein protein powder supplementation in regard to body composition and resting metabolic rate; however, minimal research exists comparing the effectiveness of whey to casein supplementation. Methods: Eighteen (18) physically trained, healthy individuals (23±3.1 yrs.; 171.7cm; 12 males; 6 females) completed a randomized two condition [Combat 100% Isolate (Whey) versus Combat 100% (Casein)] by two time point [Pre-, Post-] intervention. The intervention consisted of subjects supplementing on either whey or casein in conjunction with resistance training over an 8-week period. Pre and post testing included % body fat and metabolic rate. Results: A 2x2, repeated-measures analysis of variance (ANOVA) demonstrated non-significant (p ≥ 0.05) effects on changes in % body fat and resting metabolic rate following the 8-week intervention. Conclusions: The data concludes no differences in the effects of whey versus casein protein supplementation in physically active, healthy individuals
Compensation of spectral artifacts in dual-modality intravascular optical coherence tomography and near-infrared spectroscopy (Conference Presentation) (2016)

Intravascular optical coherence tomography (OCT) is a high-resolution catheter-based imaging method that provides three-dimensional microscopic images of coronary artery in vivo, facilitating coronary artery disease treatment decisions based on detailed morphology. Near-infrared spectroscopy (NIRS) has proven to be a powerful tool for identification of lipid-rich plaques inside the coronary walls. We have recently demonstrated a dual-modality intravascular imaging technology that integrates OCT and NIRS into one imaging catheter using a two-fiber arrangement and a custom-made dual-channel fiber rotary junction. It therefore enables simultaneous acquisition of microstructural and composition information at 100 frames/second for improved diagnosis of coronary lesions. The dual-modality OCT-NIRS system employs a single wavelength-swept light source for both OCT and NIRS modalities. It subsequently uses a high-speed photoreceiver to detect the NIRS spectrum in the time domain. Although use of one light source greatly simplifies the system configuration, such light source exhibits pulse-to-pulse wavelength and intensity variation due to mechanical scanning of the wavelength. This can be in particular problematic for NIRS modality and sacrifices the reliability of the acquired spectra. In order to address this challenge, here we developed a robust data acquisition and processing method that compensates for the spectral variations of the wavelength-swept light source. The proposed method extracts the properties of the light source, i.e., variation period and amplitude from a reference spectrum and subsequently calibrates the NIRS datasets. We have applied this method on datasets obtained from cadaver human coronary arteries using a polygon-scanning (1230-1350nm) OCT system, operating at 100,000 sweeps per second. The results suggest that our algorithm accurately and robustly compensates the spectral variations and visualizes the dual-modality OCT-NIRS images. These findings are therefore crucial for the practical application and clinical translation of dual-modality intravascular OCT-NIRS imaging when the same swept sources are used for both OCT and spectroscopy.
A Survey of Self-Perceived Knowledge and Knowledge Gaps of Medicines Research and Development Among Finnish General Public (2020)

Abstract Background : This study explored self-reported knowledge and willingness to learn more about medicines research, development and health technology assessment among Finnish general public. It also aimed to define possible knowledge gaps and needs for public education regarding medicines research, development as well as health technology assessment.This questionnaire was originally developed as a part of the Needs Assessment Work Package of the European Patients’ Academy on Therapeutic Innovation (EUPATI) Project. The questionnaire was translated from English to Finnish and the survey was carried out in Finland in 2019. Methods: The survey was conducted as an online survey by Kantar TNS Gallup Forum online panel. The data was analyzed by using the freely available R program. Relationships between the demographic characteristics (such as age, gender and education level) of respondents and their knowledge or interest in medicines research and development were determined using Pearson’s chi-squared tests. Results: Of the 503 respondents (age 16-64) only 12% reported having good or very good knowledge of medicines research and development in general. Regarding health technology assessment, pharmacoeconomics and regulation, the percentage of respondents reporting good or very good knowledge was as low as 8%.Respondents were most interested in learning more about predictive and personalised medicine (47 %) and least interested in medicines regulation (30%) and pharmacoeconomics (31%). Those who had participated in a clinical trial had better knowledge and were significantly more interested in learning more about several aspects of medicines research, development and health technology assessment. Conclusions: Self-reported knowledge about medicines research and development and health technology assessment appears to be very low in Finland. Patient and public participation is recognized as an important and essential element in up-to-date medical research and assessment of new treatments. In order to participate as an active and equal partner in these processes, the public needs more information and education in these topics. Trial registration Not applicable
Cooperative Cardioprotection Through Adenosine A1 and A2A Receptor Agonism in Ischemia-Reperfused Isolated Mouse Heart (2010)

Recent reports have shown that adenosine A1 receptor-mediated cardioprotection requires concomitant A2 receptor activation, but no study thus far has shown that this phenomenon occurs using A1 agonists at reperfusion. Thus, we compared adenosine A2A receptor knockout (A2AKO) and wild-type mouse hearts (n = 9-11) subjected to global ischemia (30 minutes) and reperfusion (60 minutes) in the presence and absence of the A1 agonist N-cyclopentlyadenosine (CPA). We also determined the effects of selective antagonists at A2A and A2B receptors on CPA-induced protection. In wild-type hearts, CPA (100 nM) significantly (P < 0.05) improved contractility (52.7 ± 6.2% versus 23.9 ± 4.9% of preischemia), left ventricular developed pressure, end diastolic pressure; reduced infarct size (7.9 ± 1.7% versus 23.9 ± 6.6% area at risk); decreased lactate dehydrogenase efflux; and increased ERK1/2 phosphorylation at 60 minutes of reperfusion. Adenosine A2A (ZM241385, 50 nM) and A2B (MRS1754, 100 nM) receptor antagonists abolished CPA-mediated cardioprotection in wild-type groups as did the A1 receptor antagonist DPCPX (P < 0.05). In A2AKO hearts, CPA did not improve functional parameters and protective signaling with the exception of end diastolic pressure. In this model, using a clinically relevant mode of pharmacologic intervention, pERK 1/2-dependent A1-mediated cardioprotection requires a cooperative activation of A2 receptors, presumably through endogenous adenosine.