gebhart/patrepeval huggingface dataset:
The effects of osteoarthritis and age on skeletal muscle strength, Na<sup>+</sup>-K<sup>+</sup>-ATPase content, gene and isoform expression (2013)

Knee osteoarthritis (OA) is a debilitating disorder prevalent in older populations that is accompanied by declines in muscle mass, strength, and physical activity. In skeletal muscle, the Na(+)-K(+) pump (NKA) is pivotal in ion homeostasis and excitability and is modulated by disuse and exercise training. This study examined the effects of OA and aging on muscle NKA in 36 older adults (range 55-81 yr), including 19 with OA (69.9 ± 6.5 yr, mean ± SD) and 17 asymptomatic controls (CON, 66.8 ± 6.4 yr). Participants completed knee extensor strength testing and a physical activity questionnaire. A vastus lateralis muscle biopsy was analyzed for NKA content ([(3)H]ouabain binding sites), α1-3- and β1-3-isoform protein abundance (immunoblotting), and mRNA (real-time RT-PCR). The association between age and NKA content was investigated within the OA and CON groups and in pooled data. The NKA content was also contrasted between subgroups below and above the median age of 68.5 yr. OA had lower strength (-40.8%, P = 0.005), but higher NKA α2- (∼34%, P = 0.006) and α3-protein (100%, P = 0.016) abundance than CON and performed more incidental physical activity (P = 0.035). No differences were found between groups for NKA content, abundance of other NKA isoforms, or gene expression. There was a negative correlation between age and NKA content within OA (r = -0.63, P = 0.03) and with both groups combined (r = -0.47, P = 0.038). The NKA content was 25.5% lower in the older (69-81 yr) than in the younger (55-68 yr) subgroup. Hence older age, but not knee OA, was related to lowered muscle NKA content in older adults.
A single infusion of ketamine improves depression scores in patients with anxious bipolar depression (2014)

Both anxious and non-anxious patients with bipolar depression had significant antidepressant responses to ketamine, although the anxious depressed group did not show a clear antidepressant response disadvantage over the non-anxious group. Given that anxiety has been shown to be a predictor of poor treatment response in bipolar depression when traditional treatments are used, our findings suggest a need for further investigations into ketamine's novel role in the treatment of anxious bipolar depression.
LookTel --- Computer Vision Applications for the Visually Impaired - eScholarship (2013)

The modern world is predominantly visual. While most people live and function with vision, many people live their lives with limited or no vision at all. The system presented in this dissertation aims to use computer vision techniques to improve the lives of individuals having severe visual impairments or blindness. By applying real-time image recognition in an accessible manner the system facilitates increased personal independence. The system presented here substantially advances the state of the art both in terms of the speed, accuracy, and robustness to the real-world variability. The real-time on-device recognition speed enables more than just object identification; it permits detection -- finding the desired item among others. The high accuracy and robustness expands the ability for people to participate in commerce and expand roles for economic participation in multiple cultures. We present an extensive evaluation demonstration and a real-world public release of the system.
The SPES target chamber remote handling system (2013)

In the framework of the EURISOL [1] program to define a second generation RIB (Radioactive Ion Beam) facility, LNL-INFN is constructing in the next five years a specialized national facility for exotic beams based on ISOL method with a uranium compound target, named SPES (Selective Production of Exotic Species) [2]. The RIBs are produced inside the target chamber complex. For radioprotection issues, the SPES target chamber [3] must be easily and safely removed, for servicing or storing, from the beam lines after the irradiation process. The design of the SPES layout strongly takes into account this effect. In fact, two independent devices are designed for the handling process, one in horizontal and the other in vertical direction, of the target chamber unit device, which contains the production target and ion source complex. The remote handling system, at present adopted for the SPES project, is presented and discussed in this work.
Low-power &amp;#x201C;Smart&amp;#x201D; CMOS image sensors (2008)

Fast development of low-power miniature CMOS sensors triggers their penetration to various applications, such as bio-medical applications, digital still and video cameras, cellular phones, web and security cameras and many other applications. The advantages of CMOS imagers over conventional CCD sensors are the possibility in integration of all functions required for timing, exposure control, color processing, image enhancement, image compression, analog-to-digital (ADC) conversion on the same chip and low-power operation. However, although CMOS imagers naturally provide low-power dissipation, their wide utilization in various portable battery-operated devices generates an increased demand for more aggressive power reduction. This paper presents a “smart” image sensor architecture and reviews general considerations for power reduction in CMOS image sensors at all possible design levels - technology, device, circuit, logic, architecture, algorithm and system integration.
Prostate innervation (1998)

The growth of the prostate gland has been considered to be controlled exclusively by endocrine means. The abundance of alpha adrenergic and muscarinic receptors and nerve fibers suggests that the autonomic nervous system may in fact play a role in the growth maturation and secretory functions of the prostate. The predominant adrenergic input to the prostate is from short adrenergic neurons, while cholinergic nerves are closely related to the glandular epithelium, presumably affecting a secretory function. The prostate has a high density of alpha-1 and beta-2 adrenergic receptors, and the presence of these receptors, as well as their regulation by androgens, suggests and supports the direct mitogenic effect of catecholamines on prostate growth. The activated signal transduction pathways in these neural systems also appear to modulate prostatic function and growth. Denervation of the prostate results in a loss of functional and structural integrity of the gland. The effects of sympathectomy and parasympathectomy support the conclusion that the dichotomy of function in prostatic autonomic innervation has a fundamental regulatory purpose. The majority of the afferent innervation to the ventral prostate is localized to sensory nerves from the L5 and L6 segments. There is some smaller degree of innervation from T13−L2. There is evidence of extensive bilateral innervation of pelvic viscera. Despite the importance of afferent sensory feedback in regulating the control of prostate growth, its effect is of a smaller magnitude than that observed with androgens. Regardless of the specific control mechanisms suggested by neural involvement in the growth differentiation and secretory function of the prostate, the presence of innervation appears to be consistent and reproducible, and holds great potential for increasing our understanding of pathologic influences in prostate disease. Prostate Supplement 8:2–13, 1998. © 1998 Wiley-Liss, Inc.
Ehrlichia chaffeensis EplA Interaction With Host Cell Protein Disulfide Isomerase Promotes Infection (2020)

<i>Ehrlichia chaffeensis</i> is an obligate intracellular bacterium that invades monocytes to cause the emerging and potentially severe disease, monocytic ehrlichiosis. Ehrlichial invasion of host cells, a process that is essential for the bacterium's survival and pathogenesis, is incompletely understood. In this study, we identified ECH_0377, henceforth designated as EplA (<i>E. chaffeensis</i> PDI ligand A) as an <i>E. chaffeensis</i> adhesin that interacts with host cell protein disulfide isomerase (PDI) to mediate bacterial entry into host cells. EplA is an outer membrane protein that <i>E. chaffeensis</i> expresses during growth in THP-1 monocytic cells. Canine sera confirmed to be positive for exposure to <i>Ehrlichia</i> spp. recognized recombinant EplA, indicating that it is expressed during infection <i>in vivo</i>. EplA antiserum inhibited the bacterium's ability to infect monocytic cells. The EplA-PDI interaction was confirmed via co-immunoprecipitation. Treating host cell surfaces with antibodies that inhibit PDI and/or thioredoxin-1 thiol reductase activity impaired <i>E. chaffeensis</i> infection. Chemical reduction of host cell surfaces, but not bacterial surfaces with tris(2-carboxyethyl)phosphine (TCEP) restored ehrlichial infectivity in the presence of the PDI-neutralizing antibody. Antisera specific for EplA C-terminal residues 95-104 (EplA<sub>95-104</sub>) or outer membrane protein A amino acids 53-68 (OmpA<sub>53-68</sub>) reduced <i>E. chaffeensis</i> infection of THP-1 cells. Notably, TCEP rescued ehrlichial infectivity of bacteria that had been treated with anti-EplA<sub>95-104</sub>, but not anti-EcOmpA<sub>53-68</sub>. These results demonstrate that EplA contributes to <i>E. chaffeensis</i> infection of monocytic cells by engaging PDI and exploiting the enzyme's reduction of host cell surface disulfide bonds in an EplA C-terminus-dependent manner and identify EplA<sub>95-104</sub> and EcOmpA<sub>53-68</sub> as novel ehrlichial receptor binding domains.
Hypoxia-reoxygenation induced damage in the myocardium: the role of mitochondria (1990)

Conference Article| August 01 1990 Hypoxia-reoxygenation induced damage in the myocardium: the role of mitochondria V. M. DARLEY-USMAR; V. M. DARLEY-USMAR †Biochemical Sciences, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. R. SMITH; D. R. SMITH †Biochemical Sciences, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar V. J. O'LEARY; V. J. O'LEARY †Biochemical Sciences, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. STONE; D. STONE †Biochemical Sciences, Wellcome Research Laboratories, Beckenham, Kent BR3 3BS, U.K. Search for other works by this author on: This Site PubMed Google Scholar D. L. HARDY; D. L. HARDY *Department of Biochemistry, St Bartholomew's Medical College, University of London, Charterhouse Square, London EC1M 6BQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar J. B. CLARK J. B. CLARK *Department of Biochemistry, St Bartholomew's Medical College, University of London, Charterhouse Square, London EC1M 6BQ, U.K. Search for other works by this author on: This Site PubMed Google Scholar Biochem Soc Trans (1990) 18 (4): 526–528. https://doi.org/10.1042/bst0180526 Article history Received: December 20 1989 Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Facebook Twitter LinkedIn MailTo Cite Icon Cite Get Permissions Citation V. M. DARLEY-USMAR, D. R. SMITH, V. J. O'LEARY, D. STONE, D. L. HARDY, J. B. CLARK; Hypoxia-reoxygenation induced damage in the myocardium: the role of mitochondria. Biochem Soc Trans 1 August 1990; 18 (4): 526–528. doi: https://doi.org/10.1042/bst0180526 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAll JournalsBiochemical Society Transactions Search Advanced Search This content is only available as a PDF. © 1990 Biochemical Society1990 Article PDF first page preview Close Modal You do not currently have access to this content.
<i>catena</i>-Poly[[[triaquabis(2,6-diacetamidobenzoato)terbium(III)]-μ-2,6-diacetamidobenzoato] monohydrate] (2004)

The title compound, {[Tb(C11H11N2O4)3(H2O)3]·H2O}n, has a Tb ion coordinated by bulky benzoate ligands. The Tb ion coordination sphere is occupied by nine O atoms, five from benzoate groups, three from water mol­ecules and one from an amide carbonyl group of a neighboring ligand. Five amide NH groups of the three ligands are involved in intramolecular N—H⋯O hydrogen bonds.
Long‐term efficacy and safety of intravenous injection of clonal mesenchymal stem cells derived from bone marrow in five adults with moderate to severe atopic dermatitis (2021)

Abstract Atopic dermatitis is a chronic and relapsing inflammatory skin disease that is treated with immunosuppressants. However, long‐term use of immunosuppressants may cause toxicity and severe side‐effects. To confirm the long‐term efficacy and safety of clonal mesenchymal stem cell therapy, we performed investigator‐initiated clinical trials and long‐term observation in five adult patients with moderate to severe atopic dermatitis that was refractory to conventional treatments. The clinical response assessment values such as Eczema Area and Severity Index (EASI) improved significantly at 16 weeks, and 80% (4/5) of the patients achieved EASI‐50 after one or two treatment cycles. Patients were observed for long‐term efficacy and safety for an average of 38 weeks (range, 16–86) and showed no serious side‐effects. Among the cytokines tested, CCL‐17, interleukin (IL)‐13, and IL‐22 significantly decreased at the end‐point of the five participants, two patients who maintained good clinical response over 84 weeks showed increased IL‐17 cytokine levels in the blood.
Complications and Consequences of Endotracheal Intubation and Tracheotomy. A Prospective Study of 150 Critically Ill Adult Patients (1981)

STAUFFER, J. L.; OLSON, D. E.; PETTY, T. L.; Fairley, H. Barrie M.B., B.S. Author Information
A Measurement of the Solar and Sidereal Cosmic-Ray Anisotropy at E 0 approximately 10 14 eV (1996)

The results of the measurement of the cosmic-ray solar and sidereal anisotropies at primary energy E<SUB>O</SUB> ≍ 10<SUP>14</SUP> eV performed by the EAS-TOP Extensive Air Shower array (Campo Imperatore, National Gran Sasso Laboratories, 2005 m above sea level, latitude 42°.5 N are presented. The measurement includes 4 years of data taking (1990, 1992, 1993, 1994) for a total of 1.3 x 10<SUP>9</SUP> events and is performed at two different mean primary energies: E<SUP>v</SUP><SUB>O</SUB> ≍ 1.5 × 10<SUP>14</SUP> eV and E<SUP>i</SUP><SUB>O</SUB> ≍ 2.5 × 10<SUP>14</SUP> eV. The two results are compatible (within 2 σ) and can therefore be combined. The obtained amplitude and phase of the first harmonic in sidereal time are (in the equatorial plane) A<SUB>sid,δ=O°</SUB>(E<SUB>O</SUB>≍2×10<SUP>14</SUP> eV) = (3.73±0.57) × 10<SUP>-4</SUP> and φ<SUB>sid</SUB> = 1.82±0.49 hr local sidereal time, with significance 6.5 σ. The amplitude of the anisotropy exhibits the expected cos δ dependence. <P />A first harmonic in solar time compatible with the expected Compton-Getting effect due to the motion of revolution of the Earth around the Sun is observed with significance 7.3 σ. The corresponding measured amplitude and phase (also in the equatorial plane) are A,<SUB>sol,δ=O°</SUB>=(4.06±0.55) × 10<SUP>-4</SUP> and φ<SUB>sol</SUB> = 4.92±0.53 hr, the expected values being 4.7 x 10<SUP>-4</SUP> and 6.0 hr. Different checks of stability of the detectors and consistency of the data are presented.
Autotaxin promotes motility via G protein‐coupled phosphoinositide 3‐kinase γ in human melanoma cells (2002)

Autotaxin (ATX), an exo-nucleotide pyrophosphatase and phosphodiesterase, stimulates tumor cell motility at sub-nanomolar levels and augments invasiveness and angiogenesis. We investigated the role of G protein-coupled phosphoinositide 3-kinase gamma (PI3Kgamma) in ATX-mediated tumor cell motility stimulation. Pretreatment of human melanoma cell line A2058 with wortmannin or LY294002 inhibited ATX-induced motility. ATX increased the PI3K activity in p110gamma, but not p85, immunoprecipitates. This effect was abrogated by PI3K inhibitors or inhibited by pertussis toxin. Furthermore, stimulation of tumor cell motility by ATX was inhibited by catalytically inactive form of PI3Kgamma, strongly indicating the crucial role of PI3Kgamma for ATX-mediated motility in human melanoma cells
IRAG1 Deficient Mice Develop PKG1β Dependent Pulmonary Hypertension (2020)

PKGs are serine/threonine kinases. PKG1 has two isoforms-PKG1α and β. Inositol trisphosphate receptor (IP<sub>3</sub>R)-associated cGMP-kinase substrate 1 (IRAG1) is a substrate for PKG1β. IRAG1 is also known to further interact with IP<sub>3</sub>RI, which mediates intracellular Ca<sup>2+</sup> release. However, the role of IRAG1 in PH is not known. Herein, WT and IRAG1 KO mice were kept under normoxic or hypoxic (10% O<sub>2</sub>) conditions for five weeks. Animals were evaluated for echocardiographic variables and went through right heart catheterization. Animals were further sacrificed to prepare lungs and right ventricular (RV) for immunostaining, western blotting, and pulmonary artery smooth muscle cell (PASMC) isolation. IRAG1 is expressed in PASMCs and downregulated under hypoxic conditions. Genetic deletion of IRAG1 leads to RV hypertrophy, increase in RV systolic pressure, and RV dysfunction in mice. Absence of IRAG1 in lung and RV have direct impacts on PKG1β expression. Attenuated PKG1β expression in IRAG1 KO mice further dysregulates other downstream candidates of PKG1β in RV. IRAG1 KO mice develop PH spontaneously. Our results indicate that PKG1β signaling via IRAG1 is essential for the homeostasis of PASMCs and RV. Disturbing this signaling complex by deleting IRAG1 can lead to RV dysfunction and development of PH in mice.
Using Hybrid Change Strategies to Improve the Patient Experience in Outpatient Specialty Care (2015)

The emerging changes in healthcare impose significant burdens on integrated outpatient specialty services with respect to setting patient expectations, handling outside medical records; and coordinating specialty appointments scheduling. Moreover, because of the evolution of the electronic health record and its widespread use, it is critical that patient and physician interaction is maintained and clerical tasks are minimized. In the context of increased government regulation, declining reimbursement, and the rise of new payment models, outpatient practices need to be reimagined so that they are more efficient for the patient and the provider. The redesign of integrated outpatient specialty services can be accomplished only through teamwork, innovation, and efficient use of technology. To address these challenges, the Department of Medicine at Mayo Clinic in Scottsdale, Arizona, implemented an ideal practice design initiative that leveraged a hybrid set of change strategies. The change strategy, which was initiated after examination of current practices and design options, engaged key stakeholders and patients. A number of enablers and barriers to adoption were identified as a result of the implementation experience.
Synthetic, Structural, and Reactivity Studies of Organocobalt(III) Compounds Containing Fluorinated Alkyl Ligands (1994)

The synthesis and NMR (1H, 13C, and 19F) spectral and X-ray structural characterization of fluoroalkyl bis(dimethylglyoximato)-cobalt(III) complexes are described. A discussion on the effect of fluorine substitution on the NMR spectral properties as well as on structural parameters relevant to electron-donating and steric properties of the fluorinated alkyl ligands is presented.
Urban tunnelling in soft ground using TBMs (2006)

The increasing demand world-wide for shallow tunnels in urban areas even with complex geotechnical conditions and under highly built-up areas has enhanced the rapid technological development of the last decade. The excavation diameter has already exceeded 15 m. This paper deals in a unifying manner with the key features of this particular field of modern tunnelling: the elements of urban environment, typical ground conditions with the decisive role of ground water and the technology of face support. Particular attention is given to risk management discussing typical patterns of ground failure, the safety plan, the constructional measures and the monitoring of ground behaviour and of surface structures. Recent case histories illustrate the various problems which can arise in difficult situations and the usefulness of systematic risk management. 1 The urban environment The need for urban tunnels is growing rapidly world-wide. Frequently, nowadays, low overburden is combined with a large diameter. Figure 1 shows the breakthrough of the recently completed Zimmerberg Railway Tunnel in the heart of the city of Zurich with a bore diameter of 12.3 m (Kovari and Bosshard, 2003). The EPB shield with the largest diameter of 15.2 m is presently in operation for a road tunnel in Madrid beneath a highly built-up area (Herrenknecht and Bappler, 2005). Generally, structures of various types have to be under-tunnelled. These may be buildings, roads, railroads, bridges, etc. The sensitivity of these structures to ground settlements as well as the potential damage due to ground collapse may vary within extremely wide ranges. The presence of frequently hidden foreign objects in the ground is also one of the specific features of urban tunnelling. These include old wells, ground anchors, sheet-piles, abandoned utilities such as for gas and sewage, but also tree trunks, artificial fills, etc. In this specific field of tunnelling there are generally major constraints in the selection of the horizontal and vertical alignment. As a rule it is generally preferable to run the tunnel in public ground under main roads or streets. However, underpassing buildings,
Multi-Staged Regulation of Lipid Signaling Mediators during Myogenesis by COX-1/2 Pathways (2019)

Cyclooxygenases (COXs), including COX-1 and -2, are enzymes essential for lipid mediator (LMs) syntheses from arachidonic acid (AA), such as prostaglandins (PGs). Furthermore, COXs could interplay with other enzymes such as lipoxygenases (LOXs) and cytochrome P450s (CYPs) to regulate the signaling of LMs. In this study, to comprehensively analyze the function of COX-1 and -2 in regulating the signaling of bioactive LMs in skeletal muscle, mouse primary myoblasts and C2C12 cells were transfected with specific COX-1 and -2 siRNAs, followed by targeted lipidomic analysis and customized quantitative PCR gene array analysis. Knocking down COXs, particularly COX-1, significantly reduced the release of PGs from muscle cells, especially PGE<sub>2</sub> and PGF<sub>2α</sub>, as well as oleoylethanolamide (OEA) and arachidonoylethanolamine (AEA). Moreover, COXs could interplay with LOXs to regulate the signaling of hydroxyeicosatetraenoic acids (HETEs). The changes in LMs are associated with the expression of genes, such as <i>Itrp1</i> (calcium signaling) and <i>Myh7</i> (myogenic differentiation), in skeletal muscle. In conclusion, both COX-1 and -2 contribute to LMs production during myogenesis in vitro, and COXs could interact with LOXs during this process. These interactions and the fine-tuning of the levels of these LMs are most likely important for skeletal muscle myogenesis, and potentially, muscle repair and regeneration.
RBF-FD analysis of 2D time-domain acoustic wave propagation in heterogeneous Earth's subsurface. (2020)

Radial Basis Function-generated Finite Differences (RBF-FD) is a popular variant of local strong-form meshless methods that do not require a predefined connection between the nodes, making it easier to adapt node-distribution to the problem under consideration. This paper investigates a RBF-FD solution of time-domain acoustic wave propagation in the context of seismic modeling in the Earth's subsurface. Through a number of numerical tests, ranging from homogeneous to highly-heterogeneous velocity models, we demonstrate that the present approach can be further generalized to solve large-scale seismic modeling and full waveform inversion problems in arbitrarily complex models --- enabling more robust interpretations to geophysical observations.