gebhart/patrepeval huggingface dataset:
Systèmes à haute disponibilité - Solutions (1999)

On a choisi dans cet article, après avoir rappelé les concepts de base dans Systèmes à haute disponibilité- Concepts , de se concentrer sur les solutions permettant de construire des systèmes à haute disponibilité. L’exposé est volontairement limité aux solutions applicables à la plupart des système
Interplay among ZF-HD and GRF transcription factors during Arabidopsis leaf development (2023)

The growth-regulating factor (GRF) family of transcriptional factors are involved in the control of leaf size and senescence, inflorescence and root growth, grain size, and plant regeneration. However, there is limited information about the genes regulated by these transcriptional factors, which are in turn responsible for their functions. Using a meta-analysis approach, we identified genes encoding Arabidopsis (Arabidopsis thaliana) zinc-finger homeodomain (ZF-HD) transcriptional factors, as potential targets of the GRFs. We further showed that GRF3 binds to the promoter of one of the members of the ZF-HD family, HOMEOBOX PROTEIN 33 (HB33), and activates its transcription. Increased levels of HB33 led to different modifications in leaf cell number and size that were dependent on its expression levels. Furthermore, we found that expression of HB33 for an extended period during leaf development increased leaf longevity. To cope with the functional redundancy among ZF-HD family members, we generated a dominant repressor version of HB33, HB33-SRDX. Expression of HB33-SRDX from HB33 regulatory regions was seedling-lethal, revealing the importance of the ZF-HD family in plant development. Misexpression of HB33-SRDX in early leaf development caused a reduction in both cell size and number. Interestingly, the loss-of-function of HB33 in lines carrying a GRF3 allele insensitive to miR396 reverted the delay in leaf senescence characteristic of these plants. Our results revealed functions for ZF-HDs in leaf development and linked them to the GRF pathway.
Supplementary Table 1 from Stem Cells Increase in Numbers in Perinecrotic Areas in Human Renal Cancer (2023)

&lt;p&gt;Supplementary Table 1. Tumorigenic potential of cells sorted from normoxic and hypoxic spheres of the six xenograft models (take rate in percentage)&lt;/p&gt;
Mesothelioma as a rapidly developing Giant Abdominal Cyst (2012)

The benign cystic mesothelioma of the peritoneum is a rare lesion and is known for local recurrence. This is first case report of a rapidly developing massive abdominal tumor with histological finding of benign cystic mesothelioma (BCM). We describe a BCM arising in the retroperitoneal tis[sue on the right side, lifting ascending colon and cecum to the left side of abdomen. Patient was an active 58-year-old man who noticed a rapid abdominal swelling within a two month time period with a weight gain of 40 pounds. Patient had no risk factors including occupational (asbestos, cadmium), family history, social (alcohol, smoking) or history of trauma. We will discuss the clinical, radiologic, intra-operative, immunohistochemical, pathologic findings, and imaging six months after surgery. Patient has no recurrence and no weight gain on follow up visits and imaging.
Parametric Combustion Instabilities (2022)

View Video Presentation: https://doi.org/10.2514/6.2022-1857.vid Interestingly, otherwise linear stable systems can become unstable under some conditions due to oscillations of system parameters. While these parametric instabilities have been studied in many systems, they have yet to be identified in combustion systems. Previously, we found that the dynamic mode decomposition (DMD) failed to explain an observed CI at 170 Hz from high-speed, synchronized OH-planar laser-induced fluorescence, particle image velocimetry, CH*-chemiluminescence, and acoustic measurements, though it did identify a spinning pair of helical vortex cores wrapped around the inner recirculation zone, with a frequency near 1 kHz. In this study, we used a data decomposition technique that we developed, the ensemble averaged Floquet decomposition, to link the DMD vortex pair to two dynamical Floquet modes, one at 258 Hz and one at 170 Hz. Furthermore, we showed that the technique consistently identifies these two modes for a range of user specified inputs, indicating the method is insensitive to such choices. Specifically, the Floquet decomposition allows us to estimate, from data alone, the time-periodic system’s largest moduli Floquet multipliers and associated spatial mode shapes. Using the chemiluminescence as an approximation to the line-of-sight integrated heat release and the acoustic data, we were able to approximate the Rayleigh integral for the two Floquet modes. The 258 Hz mode was shown to be stable with respect to combustion due to a negative Rayleigh integral. In contrast, the 170 Hz mode had a positive Rayleigh integral indicating the mode is unstable with respect to combustion—positively identifying the mode as a parametric combustion instability. Physically, together with the 1 kHz helical vortex pair, this Floquet mode shows a downstream vortical structure causes significant—larger than possible from acoustics alone—transverse oscillations and these vortical structure interactions with the nozzles/wall likely cause increased mixing and rapid heat release. Viewing acoustically coupled combustion instabilities as a nonlinear, coupled system of hydrodynamics, combustion, and acoustics, the possible parametric instabilities might provide a rigorous, yet tractable method to elucidate combustion instability mechanisms.
Mechanistic Insights into C–H Borylation of Arenes with Organoiridium Catalysts Embedded in a Microporous Metal–Organic Framework (2020)

Organometallic iridium catalysts can be used in conjunction with bispinacolatodiboron (B2Pin2) to effect the borylation of a variety of substrates such as arenes, alkanes, heteroarenes, and oxygenates. Recently, efforts have also focused on integrating these catalysts into porous supports, such as metal–organic frameworks (MOFs). While the mechanism of homogeneous borylation systems has been thoroughly investigated experimentally and computationally, analogous studies in MOF-supported iridium catalysts have not been conducted. Herein, we report the mechanistic investigation of a phenanthroline-iridium catalyst immobilized in the organic linker of Universitetet i Oslo (UiO)-67 (Zr6O4(OH)4(BPDC)4(PhenDC)2, BPDC = biphenyl-4,4′-dicarboxylate, PhenDC = 1,10-phenanthroline-4,4′-dicarboxylate). By using benzene as a model substrate, variable time normalization analysis (VTNA) of the kinetic data suggested a rate law consistent with zero-order in B2Pin2, and first-order in arene. A primary kinetic isotope effect (KIE) in the time course of benzene-d6 borylation also provided complementary information about the role of the arene in the rate-determining step of the reaction. Characterization by techniques such as X-ray absorption spectroscopy (XAS) confirmed the presence of Ir(III), while pair distribution function (PDF) analysis suggested structures containing an Ir–Cl bond, further substantiated by X-ray photoelectron spectroscopy (XPS). Analysis of postcatalysis materials by inductively coupled plasma–optical emission spectroscopy (ICP-OES) revealed low boron accumulation, which may indicate an absence of boron in the resting state of the catalyst. Finally, in comparing borylation of benzene and toluene, a slight selectivity for benzene is observed, which is similar to the analogous homogeneous reaction, indicating the influence of substrate sterics on reactivity.
Histograms as a side effect of data movement for big data (2014)

Histograms are a crucial part of database query planning but their computation is resource-intensive. As a consequence, generating histograms on database tables is typically performed as a batch job, separately from query processing. In this paper, we show how to calculate statistics as a side effect of data movement within a DBMS using a hardware accelerator in the data path. This accelerator analyzes tables as they are transmitted from storage to the processing unit, and provides histograms on the data retrieved for queries at virtually no extra performance cost. To evaluate our approach, we implemented this accelerator on an FPGA. This prototype calculates histograms faster and with similar or better accuracy than commercial databases. Moreover, the FPGA can provide various types of histograms such as Equi-depth, Compressed, or Max-diff on the same input data in parallel, without additional overhead.
Computational discovery of p-type transparent oxide semiconductors using hydrogen descriptor (2018)

Abstract The ultimate transparent electronic devices require complementary and symmetrical pairs of n-type and p-type transparent semiconductors. While several n-type transparent oxide semiconductors like InGaZnO and ZnO are available and being used in consumer electronics, there are practically no p-type oxides that are comparable to the n-type counterpart in spite of tremendous efforts to discover them. Recently, high-throughput screening with the density functional theory calculations attempted to identify candidate p-type transparent oxides, but none of suggested materials was verified experimentally, implying need for a better theoretical predictor. Here, we propose a highly reliable and computationally efficient descriptor for p-type dopability—the hydrogen impurity energy. We show that the hydrogen descriptor can distinguish well-known p-type and n-type oxides. Using the hydrogen descriptor, we screen most binary oxides and a selected pool of ternary compounds that covers Sn 2+ -bearing and Cu 1+ -bearing oxides as well as oxychalcogenides. As a result, we suggest La 2 O 2 Te and CuLiO as promising p-type oxides.
In vitro antimicrobial susceptibility of <i>Mycoplasma bovis</i> clinical isolates recovered from bison (<i>Bison bison</i>) (2015)

Mycoplasma bovis is a pathogen globally affecting cattle and bison herds, causing pneumonia, arthritis, mastitis, abortions, and other symptoms, leading to huge economic losses. Many studies have been done regarding the antimicrobial susceptibility of M. bovis isolated from cattle, but no such study is available for isolates recovered from bison. For the first time, in vitro susceptibilities of 40 M. bovis clinical isolates collected from bison herds in Canada are reported here. Minimal inhibitory concentration (MIC) values were determined using Sensititre® plates. The most effective MIC50 and MIC90 were for spectinomycin (1 and >64 μg/mL), tiamulin (1 and >32 μg/mL), and tulathromycin (16 and 64 μg/mL), whereas tetracyclines, fluoroquinolones, and florfenicol failed to inhibit growth of M. bovis bison isolates. Isolates were nonsusceptible to tetracyclines (100%), fluoroquinolones (97.5%), and tilmicosin (100%), whereas the highest susceptibility of bison clinical isolates was seen with spectinomycin (95%) and tulathromycin (67.5%). Two lung isolates (Mb283 and 348) were found resistant to both spectinomycin and tulathromycin. These results show a marked difference in antimicrobial susceptibility of bison isolates as compared with previously reported and laboratory reference cattle isolates, emphasizing the necessity of testing antimicrobial susceptibility of M. bovis bison isolates and to generate better therapeutic regime for improved recovery chances for infected bison herds across North America.
Electro-optically based liquid mass sensor using resonating micro-plate under harsh drop and spray conditions (2014)

We perform in-situ sensing of volatile droplet and spray masses using plate-like single crystal Si micro-resonators with low stress, where robust and reusable operation was attained over harsh conditions and over multiple cycles. A home-built electro-optical sensing system has been used. The effects on the resonant frequency of altered mass loading, elasticity and strain are compared, where the latter two mechanisms are found to be negligible in the presence of low viscosity liquids deposited on top of our devices. In resonant mode, the loaded mass is estimated from measured frequency response shifts and interpreted from simple (uniformly deposited film) model.
Data from Mesenchymal Stem Cells from Human Fat Engineered to Secrete BMP4 Are Nononcogenic, Suppress Brain Cancer, and Prolong Survival (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; Glioblastoma is the most common adult primary malignant intracranial cancer. It is associated with poor outcomes because of its invasiveness and resistance to multimodal therapies. Human adipose-derived mesenchymal stem cells (hAMSC) are a potential treatment because of their tumor tropism, ease of isolation, and ability to be engineered. In addition, bone morphogenetic protein 4 (BMP4) has tumor-suppressive effects on glioblastoma and glioblastoma brain tumor–initiating cells (BTIC), but is difficult to deliver to brain tumors. We sought to engineer BMP4-secreting hAMSCs (hAMSCs-BMP4) and evaluate their therapeutic potential on glioblastoma.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The reciprocal effects of hAMSCs on primary human BTIC proliferation, differentiation, and migration were evaluated &lt;i&gt;in vitro&lt;/i&gt;. The safety of hAMSC use was evaluated &lt;i&gt;in vivo&lt;/i&gt; by intracranial coinjections of hAMSCs and BTICs in nude mice. The therapeutic effects of hAMSCs and hAMSCs-BMP4 on the proliferation and migration of glioblastoma cells as well as the differentiation of BTICs, and survival of glioblastoma-bearing mice were evaluated by intracardiac injection of these cells into an &lt;i&gt;in vivo&lt;/i&gt; intracranial glioblastoma murine model.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; hAMSCs-BMP4 targeted both the glioblastoma tumor bulk and migratory glioblastoma cells, as well as induced differentiation of BTICs, decreased proliferation, and reduced the migratory capacity of glioblastomas &lt;i&gt;in vitro&lt;/i&gt; and &lt;i&gt;in vivo&lt;/i&gt;. In addition, hAMSCs-BMP4 significantly prolonged survival in a murine model of glioblastoma. We also demonstrate that the use of hAMSCs &lt;i&gt;in vivo&lt;/i&gt; is safe.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Both unmodified and engineered hAMSCs are nononcogenic and effective against glioblastoma, and hAMSCs-BMP4 are a promising cell-based treatment option for glioblastoma. &lt;i&gt;Clin Cancer Res; 20(9); 2375–87. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
On the Stochastic Link Modeling of Static Wireless Sensor Networks in Ocean Environments (2019)

Despite the advantages that ocean surface Wireless Sensor Networks (WSN) have over traditional ocean monitoring methods, ocean WSN research suffers from lack of an accurate model that describes the stability of wireless links among sensor nodes. In this paper, we are going to investigate ocean surface waves' effects on the Line-of-Sight (LoS) link between sensors in a homogeneous WSN. Specifically, we will derive the blockage probability of LoS links between a transmitter and receiver pair due to wave movements, and analyze how environmental effects like wind speed affect it. Simulation results along with oceanographic measurements validate our analyses, making our model applicable in design and planning of WSN in the ocean environment.
Crystallization of Polystyrene‐<i>block</i>‐[Syndiotactic Poly(propylene)] Block Copolymers from Confinement to Breakout (2005)

Abstract Summary: Various crystalline textures have been identified in a crystallizable block copolymer system, polystyrene‐ block ‐[syndiotactic poly(propylene)] (PS‐sPP), having a glass‐transition temperature of PS ( T g,PS ) located in the midst of the sPP crystallization window. A confined morphology for the crystallization of sPP was observed while the crystallization temperature of sPP ( T c,sPP ) was less than T g,PS . A further increase in T c,sPP could lead to a breakout in nanostructure. This study revealed the T g effect on crystallization‐induced morphological changes of block copolymers from confinement to breakout. TEM images and one‐dimensional SAXS profiles of PS‐sPP isothermally crystallized at T ODT &gt; T g,PS &gt; T c,sPP (top) and T ODT &gt; T c,sPP &gt; T g,PS (bottom). image TEM images and one‐dimensional SAXS profiles of PS‐sPP isothermally crystallized at T ODT &gt; T g,PS &gt; T c,sPP (top) and T ODT &gt; T c,sPP &gt; T g,PS (bottom).
Ethnicity and the diagnosis gap in liver disease: a population-based study (2014)

Abnormal LFTs are common in the population, but are underinvestigated and often remain undiagnosed. Bangladeshi ethnicity is an important independent risk factor for NAFLD.
Phenomenological Models in Uncertainty Framework - a Way to Assess Local Recovery Factor Ranges of Large Scale Fields (2002)

F-13 PHENOMENOLOGICAL MODELS IN UNCERTAINTY FRAMEWORK - A WAY TO ASSESS LOCAL RECOVERY FACTOR RANGES OF LARGE SCALE FIELDS Abstract: Hydrocarbon fields targeted by oil companies are frequently large scale fields with a dense well coverage and a complex facies architecture and petrophysical filling (Texas fields Siberian fields Canadian heavy oil fields …). A full field dynamic model of such objects is often far from the objective of accurate prediction of global production profile; the reason being is the limited number of cells imposed to prevent prohibitive simulation CPU time which restricts heterogeneity modeling to major global events. In this
Phenotypic and functional characterisation of CD8 memory T cells generated in T cell receptor transgenic mice (1998)

La memoire immunitaire, c'est-a-dire la capacite du systeme immunitaire a repondre plus rapidement et plus efficacement vis-a-vis d'antigenes deja rencontres dans le passe, permet une immunite protectrice. Cependant, si la reponse immunitaire vis-a-vis d'antigenes secondaires est bien caracterisee, les bases cellulaires et moleculaires de la memoire immunitaire sont encore mal definies. Nous avons utilise des souris transgeniques pour le recepteur d'antigene de lymphocytes t afin de caracteriser la differenciation et le phenotype de lymphocytes t cd8 a memoire. Nos resultats montrent que la majorite des lymphocytes t cd8 primes obtenus dans ce systeme ne se divisent pas et expriment des taux plus eleves de cd44 et ly6c que les lymphocytes t cd8 naifs. Contrairement a d'autres systemes, nous n'avons pas observe de diminution de l'expression de cd45ra et cd45rb a la surface de lymphocytes t cd8 primes. Fonctionnellement, les lymphocytes t cd8 primes sont capables de repondre a une deuxieme stimulation par l'antigene in vivo. In vitro, les lymphocytes t cd8 primes sont actives par des concentrations de peptide 10 a 30 fois plus faibles que les lymphocytes t cd8 naifs en presence d'interleukine-2. De plus, les lymphocytes t cd8 primes produisent cinq fois plus d'interferon-gamma que les lymphocytes t cd8 naifs. Ces lymphocytes t cd8 primes pourraient jouer un role important dans la reponse memoire.
Junction Stability of B Doped Layers in SOI Formed with Optimized Vacancy Engineering Implants (2006)

Forming highly stable, low resistive, ultra shallow p‐type junctions is well known to be a challenge for future transistor devices. This paper investigates the junction stability of boron layers formed with an optimized 160keV silicon vacancy engineering implant in SOI. It is demonstrated that when the electrical activation is well above the solid solubility a combination of diffusion and possible boron precipitation, during prolonged annealing at 850°C, drives the boron to return to an equilibrium level of electrical activation, which is compensated by the carrier mobility to maintain a constant Rs. Reducing the anneal temperature to 700°C shows it is possible to create highly stable p‐type junctions in terms of diffusion and sheet resistance.
The effect of the MgO buffer layer thickness on magnetic anisotropy in MgO/Fe/Cr/MgO buffer/MgO(001) (2016)

The relationship between the magnetic properties and MgO buffer layer thickness d was studied in epitaxial MgO/Fe(t)/Cr/MgO(d) layers grown on MgO(001) substrate in which the Fe thickness t ranged from 0.4 nm to 1.1 nm. For 0.4 nm ≤ t ≤ 0.7 nm, a non-monotonic coercivity dependence on the MgO buffer thickness was shown by perpendicular magneto-optic Kerr effect magnetometry. For thicker Fe films, an increase in the buffer layer thickness resulted in a spin reorientation transition from perpendicular to the in-plane magnetization direction. Possible origins of these unusual behaviors were discussed in terms of the suppression of carbon contamination at the Fe surface and changes in the magnetoelastic anisotropy in the system. These results illustrate a method to control magnetic anisotropy in MgO/Fe/Cr/MgO(d) via an appropriate choice of MgO buffer layer thickness d.
Antiproliferative effects of triterpenoidal derivatives, obtained from the marine sponge <i>Siphonochalina</i> sp., on human hepatic and colorectal cancer cells (2016)

Three triterpenoidal derivatives [Sipholenol A (1), sipholenol L (2) and sipholenone A (3)] were isolated from the Red Sea sponge Siphonochalina sp. The structures were determined based on spectroscopic measurements (NMR, UV, IR and MS). The isolated compounds were evaluated for their cytotoxic activity against three cancer cell lines; HepG2, Caco-2 and HT-29. Moreover, the effects of these metabolites on cell cycle progression as well as cell cycle regulating proteins were assessed. Compounds 1, 2 and 3 showed moderate activity against HepG2 cells with IC(50) values of 17.18 ± 1.18, 24.01 ± 0.59 and 35.06 ± 1.10 μM, respectively. Compounds 1 and 2 exerted a considerable antiproliferative effect with IC(50) values of 4.80 ± 0.18 and 26.64 ± 0.30 μM, respectively, against Caco-2 cells. Finally, 1 and 2 exhibited antiproliferative activity against colorectal cancer cells (HT-29) with IC(50) values of 24.65 ± 0.80 and 4.48 ± 0.1 μM, respectively. Cell cycle analysis indicated that these compounds induced cell cycle arrest particularly in G0/G1 and S phases. Furthermore, the triterpenoids increased the expression of cyclin-B1, cyclin-D1 and cleaved caspase-3, as determined by immunofluorescence, indicating an important role of apoptosis in cell death induced by these compounds.
Distinct roles for renal particulate and soluble guanylyl cyclases in preserving renal function in experimental acute heart failure (2007)

Worsening renal function in the setting of human acute heart failure (AHF) predicts poor outcomes, such as rehospitalization and increased mortality. Understanding potential renoprotective mechanisms is warranted. The guanylate cyclase (GC) enzymes and their second messenger cGMP are the target of two important circulating neurohumoral systems with renoprotective properties. Specifically, natriuretic peptides (NP) released from the heart with AHF target particulate GC in the kidney, while the nitric oxide (NO) system is an activator of renal soluble GC. We hypothesized that both systems are essential to preserve renal excretory and hemodynamic function in AHF but with distinct roles. We investigated these roles in three groups of anesthetized dogs (6 each) with AHF induced by rapid ventricular pacing. After a baseline AHF clearance, each group received intrarenal vehicle (control), N(G)-monomethyl-l-arginine (l-NMMA), a competitive NO inhibitor (50 microg.kg(-1).min(-1)) or a specific NP receptor antagonist, HS-142-1 (0.5 mg/kg). We observed that intrarenal l-NMMA decreased renal blood flow (RBF) without significant decreases in glomerular filtration rate (GFR), urinary sodium excretion (UNaV), or urinary cGMP. In contrast, HS-142-1 resulted in a decrease in UNaV and cGMP excretion together with a reduction in GFR and an increase in distal fractional tubular sodium reabsorption. We conclude that in AHF, the NP system plays a role in maintaining sodium excretion and GFR, while the function of NO is in the maintenance of RBF. These studies have both physiological and therapeutic implications warranting further research into cardiorenal interactions in this syndrome of AHF.