gebhart/patrepeval huggingface dataset:
Systemic and Regional Hemodynamic Interactions of Perindopril and Nitrendipine in the Spontaneously Hypertensive Rat (1990)

Adult spontaneously hypertensive rats (SHR) were daily treated for 2 weeks with perindopril [an angiotensin-converting enzyme (ACE) inhibitor] and nitrendipine (a calcium antagonist) alone or in combination. Blood pressure (BP), heart rate (HR), and diuresis were assessed weekly in conscious rats, and systemic and regional hemodynamics were investigated by the microsphere technique at the end of the treatment in anesthetized rats. Both perindopril (2 mg.kg-1.d-1) and nitrendipine (10 mg.kg-1.d-1) decreased BP to the same extent, but perindopril exerted a longer action. The hemodynamic profile of each drug was respectively consistent with the classic ones of ACE inhibitors and calcium antagonists already described in the literature. With combination of the two treatments, effects were at least additive, except that the nitrendipine-induced tachycardia was partially reduced by perindopril. BP reduction was additive, and significant potentiation was shown at the systemic [cardiac index (CI) increase, total peripheral resistance (TPR) decrease] and some regional (hepatic, muscular, and cutaneous vasodilations) levels. These results, which are in agreement with the different mechanisms of action of the two drugs, emphasize the advantage of combining perindopril with nitrendipine for treatment of hypertension.
NBGNU: a hypoxia-activated Tripartite combi-nitrosourea Prodrug Overcoming AGT-mediated Chemoresistance (2018)

<b>Aim:</b> A hypoxia-activated combi-nitrosourea prodrug, <i>N</i>-(2-chloroethyl)-<i>N</i>'-2-(2-(4-nitrobenzylcarbamate)-<i>O</i><sup>6</sup>-benzyl-9-guanine)ethyl-<i>N</i>-nitrosourea (NBGNU), was synthesized and evaluated for its hypoxic selectivity and anticancer activity <i>in vitro</i>. <b>Results:</b> The prodrug was designed as a tripartite molecule consisting of a chloroethylnitrosourea pharmacophore to induce DNA interstrand crosslinks (ICLs) and an <i>O</i><sup>6</sup>-benzylguanine analog moiety masked by a 4-nitrobenzylcarbamate group to induce hypoxia-activated inhibition of <i>O</i><sup>6</sup>-alkylguanine-DNA alkyltransferase. NBGNU was tested for hypoxic selectivity, cytotoxicity and DNA ICLs ability. The reduction product amounts, cell death rates and DNA ICL levels induced by NBGNU under hypoxic conditions were all significantly higher than those induced by NBGNU under normoxic conditions. <b>Conclusion:</b> The tripartite combi-nitrosourea prodrug exhibits desirable tumor-hypoxia targeting ability and abolished chemoresistance compared with the conventional chloroethylnitrosoureas.
Detecting Anti-IIa and Anti-Xa Direct Oral Anticoagulant (DOAC) Agents in Urine using a DOAC Dipstick (2018)

The assessment of the anticoagulant effect of direct oral anticoagulants (DOACs) can be important for rapid medical decision-making, especially in patients needing immediate management. An assay that screens for the absence or presence of a DOAC would help accelerate treatment in these situations. Chromogenic and coagulation methods have several limitations, including limited accuracy, long turnaround time, and their need of specialized laboratories. Oral factor Xa and thrombin inhibitors are also eliminated by the kidneys and can be detected in patient urine samples using a single, rapid, sensitive, and patient-specific qualitative assay. In these tests, the presence or absence of a DOAC in urine can be identified by visually observing specific colors after a few minutes. Several studies have demonstrated the robustness and repeatability of these assays. The specific colors of the test strip also detect creatinine in the urine, which shows whether DOAC excretion is reduced, thus suggesting renal impairment. Persons with amblyopia may use a specific reader. Current indications for using the <i>DOAC Dipstick</i> test include emergency medical situations with severe bleeding and thrombotic events or before urgent major surgical interventions to accelerate medical decision-making.
Long-term outcomes after surgical ablation for atrial fibrillation in patients with continuous heart rhythm monitoring devices (2015)

Continuous rhythm disclosure reveals that very small amounts of AF burden after surgical ablation are common. The preoperative duration of AF and the use of a box lesion only in patients with longer AF persistence history were independently associated with higher postoperative AF burden recurrence. The temporal AF pattern during the blanking period after ablation should be considered for further patient management and might serve as a prognostic factor.
In situ transcriptome characteristics are lost following culture adaptation of adult cardiac stem cells (2018)

Regenerative therapeutic approaches for myocardial diseases often involve delivery of stem cells expanded ex vivo. Prior studies indicate that cell culture conditions affect functional and phenotypic characteristics, but relationship(s) of cultured cells derived from freshly isolated populations and the heterogeneity of the cultured population remain poorly defined. Functional and phenotypic characteristics of ex vivo expanded cells will determine outcomes of interventional treatment for disease, necessitating characterization of the impact that ex vivo expansion has upon isolated stem cell populations. Single-cell RNA-Seq profiling (scRNA-Seq) was performed to determine consequences of culture expansion upon adult cardiac progenitor cells (CPCs) as well as relationships with other cell populations. Bioinformatic analyses demonstrate that identity marker genes expressed in freshly isolated cells become undetectable in cultured CPCs while low level expression emerges for thousands of other genes. Transcriptional profile of CPCs exhibited greater degree of similarity throughout the cultured population relative to freshly isolated cells. Findings were validated by comparative analyses using scRNA-Seq datasets of various cell types generated by multiple scRNA-Seq technology. Increased transcriptome diversity and decreased population heterogeneity in the cultured cell population may help account for reported outcomes associated with experimental and clinical use of CPCs for treatment of myocardial injury.
Capacity analysis for noncooperative interference environments (2005)

To enhance the wireless bandwidth utilization, new forms of innovative spectrum policies, dynamically sharing channels over time and space, have been discussed. Dynamic spectrum access lets systems share the spectrum, to achieve better bandwidth utilization and trunking gains. In this work, we consider a case where such access is performed in an uncoordinated fashion. The paradigm shift to open frequency bands implies a need to investigate and verify resulting capacity gains. Herein, we give a general method for evaluating system capacity subject to outage probability constraints over fading channels, in an unlicensed band environment with uncoordinated systems. The channel fading effects include both attenuation, shadowing and multipath propagation and we end up with expressions, which are solved by numerical integration. The spectrum sharing is here performed by means of autonomous dynamic channel allocation (DCA), and we compare two DCA methods, maximum SIR DCA and random DCA.
How Much Protoporphyrin IX Must Be Activated to Obtain Full Efficacy of Methyl Aminolevulinate Photodynamic Therapy? Implication for Treatment Modifications (2021)

Photodynamic therapy (PDT) with methyl aminolevulinate (MAL) is a popular treatment for actinic keratoses (AK), and several PDT treatment modalities with similar cure rates are in use. The effect relies on the activation of protoporphyrin IX (PpIX) in premalignant cells. This study aimed to measure PpIX during each treatment modality to determine the minimal PpIX activation and shortest exposure time for optimal cure rate. In four different treatment modalities, we established the PpIX formation up to three hours after MAL application without illumination and measured the speed of PpIX photoactivation during 9 min of red light (37 J/cm<sup>2</sup>). The level of PpIX three hours after MAL application was set to 100 PpIX units. In comparison, 85 PpIX units were formed during daylight PDT, 57 PpIX units during pulse PDT, and 52 PpIX units without any curettage prior to MAL. The activation of 50 PpIX units should, therefore, be enough to obtain a full effect on AK. Further, red light illumination may be shortened from 9 min to 1-2 min. The results indicate that PDT can be performed successfully with half the illumination time used in daylight PDT today and with one fourth of the illumination time used in classical PDT.
Variable-angle high-angle annular dark-field imaging: application to three-dimensional dopant atom profiling (2015)

Abstract Variable-angle high-angle annular dark-field (HAADF) imaging in scanning transmission electron microscopy is developed for precise and accurate determination of three-dimensional (3D) dopant atom configurations. Gd-doped SrTiO 3 films containing Sr columns containing zero, one, or two Gd dopant atoms are imaged in HAADF mode using two different collection angles. Variable-angle HAADF significantly increases both the precision and accuracy of 3D dopant profiling. Using image simulations, it is shown that the combined information from the two detectors reduces the uncertainty in the dopant depth position measurement and can uniquely identify certain atomic configurations that are indistinguishable with a single detector setting. Additional advances and applications are discussed.
Discriminative Training for Automatic Speech Recognition: Modeling, Criteria, Optimization, Implementation, and Performance (2012)

Discriminative training techniques have been shown to consistently outperform the maximum likelihood (ML) paradigm for acoustic model training in automatic speech recognition (ASR). Consequently, today's discriminative training methods are fundamental components of state-of-the-art systems and are a major line of research in speech recognition. This article gives a comprehensive overview of discriminative training methods for acoustic model training in the context of ASR. The article covers all related aspects of discriminative training for speech recognition, i.e., specific training criteria and their relation, statistical modeling, different parameter optimization approaches, efficient implementation of discriminative training, and a performance overview.
'Circle Segments': A Technique for Visually Exploring Large Multidimensional Data Sets (1996)

In this paper, we describe a novel technique for visualizing large amounts of high-dimensional data, called ‘circle segments’. The technique uses one colored pixel per data value and can therefore be classified as a pixel-per-value technique [Kei 96]. The basic idea of the ‘circle segments ’ visualization technique is to display the data dimensions as segments of a circle. If the data consists of k dimensions, the circle is partitioned into k segments, each representing one data dimension. Inside the segments, the data values belonging to one dimension are arranged from the center of the circle to the outside in a back and forth manner orthogonal to the line that halves the segment. Our first results show that the ‘circle segment’ technique is very powerful for visualizing large amounts of data, providing more expressive visualizations than other wellknown techniques such as the ‘recursive pattern ’ technique and traditional
Advances in Biofunctional SERS-Active Nanoparticles for Future Clinical Diagnostics and Therapeutics (2016)

The synergy afforded by the combination of biofunctionalised nanoparticles and surface enhanced Raman scattering (SERS) has expanded the analytical toolbox for clinical diagnostics and therapeutics. Since their inception, SERS-active nanoparticles have been developed into biofunctional nanoparticles (BFNPs) using a variety of methods to attach biomolecules and pacification layers to nanoparticles to enable detection of various diseases or cancers in vitro and in vivo. However, while there are many reports of the use of BFNPs for diagnostic or therapeutic applications, very few are implemented in a “real” clinical setting, for example, detection of disease biomarkers in tissue or the delivery of drugs to affected cells. This review covers recent advances made in the development of BFNPs for SERS-based detection of clinical samples using in vitro and in vivo methods.
Scale-Dependent Electrostatic Stiffening in Biopolymers (2009)

Using a combination of the molecular dynamics simulations and theoretical calculations, we have demonstrated that bending rigidity of biological polyelectrolytes (semiflexible charged polymers) is scale-dependent. A bond−bond correlation function describing a chain’s orientational memory can be approximated by a sum of two exponential functions manifesting the existence of the two characteristic length scales. One describes the chain’s bending rigidity at the distances along the polymer backbone shorter than the Debye screening length, whereas another controls the long-scale chain’s orientational correlations. The short-length scale bending rigidity is proportional to the Debye screening length at high salt concentrations and shows a weak logarithmic dependence on salt concentration when the Debye screening length exceeds a crossover value of κcr−1 ∝ (lBα2/lp)−1/2 (where lB is the Bjerrum length, α is the fraction of ionized groups, and lp is a bare persistence length). The long-scale chain’s bending rigidity has a well-known Odijk−Skolnick−Fixman form with a quadratic dependence on the Debye radius. Simulation results and a theoretical model demonstrate good qualitative agreement.
A Systematic Review of Motivational Interviewing in Healthcare: The Potential of Motivational Interviewing to Address the Lifestyle Factors Relevant to Multimorbidity (2015)

Internationally, health systems face an increasing demand for services from people living with multimorbidity. Multimorbidity is often associated with high levels of treatment burden. Targeting lifestyle factors that impact across multiple conditions may promote quality of life and better health outcomes for people with multimorbidity. Motivational interviewing (MI) has been studied as one approach to supporting lifestyle behaviour change. A systematic review was conducted to assess the effectiveness of MI in healthcare settings and to consider its relevance for multimorbidity. Twelve meta-analyses pertinent to multimorbidity lifestyle factors were identified. As an intervention, MI has been found to have a small-to-medium statistically significant effect across a wide variety of single diseases and for a range of behavioural outcomes. This review highlights the need for specific research into the application of MI to determine if the benefits of MI seen with single diseases are also present in the context of multimorbidity.
Molecularly Imprinted Nanofiber Membranes from Carboxylated Polysulfone by Electrospray Deposition (2007)

Abstract It is demonstrated that polymeric materials can be directly converted into molecular (chiral) recognition nanofiber membranes by simultaneously applying an electrospray deposition and an alternative molecular imprinting during the membrane preparation process. Polysulfone with a degree of substitution of 0.88 was adopted as the candidate polymeric material for molecularly imprinted nanofiber membranes. Molecularly imprinted nanofiber membranes imprinted by Z ‐ D ‐Glu recognize the D ‐isomer in preference to the corresponding L ‐isomer and vice versa. The amino acid preferentially incorporated into the membrane is selectively permeated through the membrane by using a concentration gradient as a driving force for membrane transport. magnified image
Photoreplicated Anisotropic Liquid‐Crystalline Lenses for Aberration Control and Dual‐Layer Readout of Optical Discs (2003)

Abstract This work describes the functional characterization of novel photoreplicated anisotropic lenses obtained from molds with different curvatures. These lenses were prepared by the photopolymerization of mixtures of a reactive liquid‐crystalline bisacrylate and non‐reactive derivatives of liquid‐crystalline cyanobiphenyl. The phase diagrams, the polymerization kinetics as a function of temperature, and the birefringence as a function of temperature for various mixtures were determined. For the fabrication of lenses, the average liquid‐crystal (LC) director of the mixtures has to be aligned in a single direction. Photoalignment and rubbing techniques were investigated to create a monodomain of the reactive material. Finally, optimal mixtures were used for the fabrication of anisotropic lenses. Aberrations were below 20 mλ root mean square (rms), which makes these LC lenses interesting for application in light paths, for example, as spherical aberration correction devices for dual‐ (or multiple‐) layer optical storage.
Electro-organic reactions. Part 54. Quinodimethane chemistry. Part 2. Electrogeneration and reactivity of o-quinodimethanes (2001)

The electrochemical generation and characterisation of a variety of o-quinodimethanes (o-QDMs) are described together with the outcome of preparative experiments in which they are key intermediates. The quinodimethanes are conveniently formed, in DMF, by both direct and redox-catalysed electroreduction of 1,2-bis(halomethyl)arenes. Their predominant reaction is polymerisation to poly(o-xylylene) (o-PX) polymers. In the presence of dienophiles the electrogenerated o-QDMs may undergo efficient cycloaddition reaction and distinctions between the possible mechanisms have been attempted on the basis of voltammetric, preparative and stereochemical experiments. Contrary to the precedent of the corresponding methyl ester, diphenyl maleate radical-anion isomerises only slowly to the fumarate radical-anion, yet co-electrolysis of 2,3-bis(bromomethyl)-1,4-dimethoxybenzene and diphenyl maleate or diphenyl fumarate gives exclusively the corresponding trans-adduct. Co-electrolysis of dimethyl maleate with either 1,2-bis(bromomethyl)benzene (more easily reduced) or 2,3-bis(bromomethyl)-1,4-dimethoxybenzene (less easily reduced) gave only o-PX polymer. The results are rationalised in terms of a double nucleophilic substitution mechanism where electron transfer between dienophile radical-anion and dihalide is relatively slow. Where electron transfer from maleate or fumarate radical-anions is likely to be fast o-quinodimethanes are formed by redox-catalysis and they polymerise rather than undergo Diels–Alder reaction. Dimerisation of the dienophile radical-anions, with k2 = 104 to 105 M−1 s−1, does not apparently compete with nucleophilic substitution or, where relevant, electron transfer.
Near-Infrared Photoimmunotherapy Targeting Prostate Cancer with Prostate-Specific Membrane Antigen (PSMA) Antibody (2017)

Prostate-specific membrane antigen (PSMA) is a membrane protein that is overexpressed manifold in prostate cancer and provides an attractive target for molecular therapy. Near-infrared photoimmunotherapy (NIR-PIT) is a highly selective tumor treatment that employs an antibody-photoabsorber conjugate (APC). Here, we describe the efficacy of NIR-PIT, using a fully human IgG<sub>1</sub> anti-PSMA monoclonal antibody (mAb), conjugated to the photoabsorber, IR700DX, in a PSMA-expressing PC3 prostate cancer cell line. Anti-PSMA-IR700 showed specific binding and cell-specific killing was observed after exposure of the cells to NIR light <i>in vitro</i> In the <i>in vivo</i> study, anti-PSMA-IR700 showed high tumor accumulation and high tumor-background ratio. Tumor-bearing mice were separated into 4 groups: (i) no treatment; (ii) 100 μg of anti-PSMA-IR700 i.v.; (iii) NIR light exposure; (iv) 100 μg of anti-PSMA-IR700 i.v., NIR light exposure was administered. These were performed every week for up to 3 weeks. Tumor growth was significantly inhibited by NIR-PIT treatment compared with the other control groups (<i>P</i> < 0.001), and significantly prolonged survival was achieved (<i>P</i> < 0.0001 vs. other control groups). More than two thirds of tumors were cured with NIR-PIT. In conclusion, the anti-PSMA antibody is suitable as an APC for NIR-PIT. Furthermore, NIR-PIT with the anti-PSMA-IR700 antibody is a promising candidate of the treatment of PSMA-expressing tumors and could be readily translated to humans.<b>Implications:</b> NIR-infrared photoimmunotherapy (NIR-PIT) using a fully human anti-PSMA-IR700 conjugate showed potential therapeutic effects against a PSMA-expressing prostate cancer that is readily translated to humans. <i>Mol Cancer Res; 15(9); 1153-62. ©2017 AACR</i>.
In-Vivo Gene Delivery by Sonoporation: Recent Progress and Prospects (2012)

The increasing knowledge of cellular and molecular mechanisms of human diseases allows envisaging the gene therapy by sonoporation as an emerging and promising therapeutic alternative. Sonoporation combines the local application of ultrasound waves and the intravascular or intratissue administration of gas microbubbles. In such a way, the permeability of vessels and tissues to the poorly permeant molecules is transiently increased. Ultrasound based modality offers new opportunities since ultrasound can be easily focused on a target tissue or organ and hence gene delivery and expression should be limited to the insonified region. Consequently, it might be possible to develop an efficient and safe tissue- or organ-specific delivery method by microbubble targeting and focused ultrasound. This review focuses on the current knowledge of sonoporation fundamentals and mechanisms. The sonoporation procedure and current preclinical trials will be then presented. Finally, the new challenges of sonoporation will be discussed. Keywords: Sonoporation, ultrasound, microbubble, gene delivery, gene therapy, intravascular, intratissue, electroporation
Effects of rotor blade modulation on gnss anti-jamming algorithms. (2014)

In hostile environment, Global Navigation Satellite System (GNSS) could be disturbed by intentional jamming. Many adaptive algorithms have been developed to deal with these threats, among which use of antenna arrays is one of the most efficient. However, most of them have been designed under stationary hypothesis and their performances in harsher environments are questionable. For instance, when a GNSS receiver is placed near rotating bodies, the signal undergo complex and non-stationary effects called Rotor Blade Modulation (RBM). These variations can degrade significantly anti-jamming performance. This paper investigates the impact of the RBM on three conventional space-time adaptive processing (STAP). First, to simulate the RBM, the signal received by an antenna mounted on a helicopter is computed thanks to electromagnetic (EM) asymptotic methods. Then, to quantify precisely the loss in performance of each algorithm, we compare post correlation carrier to noise ratio (post - C/N0) and covariance matrix estimation with respect of the time. Finally, the simulation results are confirmed by experiments conducted on an EC-120 helicopter with an L-band Continuous Wave (CW) jammer.