gebhart/patrepeval huggingface dataset:
Stability of Premicellar Aggregates in Water-in-Oil Microemulsion Systems (1985)

The stability of premicellar association structures in W/O microemulsion systems was calculated using the CNDO/2 method. The results revealed the importance of directed interaction of water molecules with the polar groups of the amphiphilic compounds. Even extremely strong hydrogen bonds such as those between ionized carboxylate and nonionized carboxylic groups could be intercalated by water molecules with energy conservation.
Strategies for Resolution of Intraprofessional Conflict Related to the Role of the Certified Occupational Therapy Assistant (1988)

The certified occupational therapy assistant's role continues to be of concern to our profession. Occupational therapy personnel have identified the same issues, especially role confusion and inadequate supervision, as problems without clear solutions for almost two decades. The author addresses these and other problems and proposes use of de Bono's lateral thinking style for problem analysis and resolution.
New Finger-Occlusion Plethysmograph for Estimating Peripheral Blood Flow and Vascular Resistance (2008)

Our newly developed FOP can estimate peripheral absolute BF easily. Furthermore, BF determined by the FOP can be used to calculate PVR, and an elevated PVR may be a useful predictor of hypertension.
Molecular mechanisms underlying K<sup>+</sup> current downregulation in canine tachycardia-induced heart failure (2005)

Heart failure (HF) is characterized by marked prolongation of action potential duration and reduction in cellular repolarization reserve. These changes are caused in large part by HF-induced K(+) current downregulation. Molecular mechanisms underlying these changes remain unclear. We determined whether downregulation of K(+) currents in a canine model of tachycardia-induced HF is caused by altered expression of underlying K(+) channel alpha- and beta-subunits encoding these currents. K(+) channel subunit expression was quantified in normal and failing dogs at the mRNA and protein levels in epicardial (Epi), midmyocardial (Mid), and endocardial (Endo) layers of left ventricle. Analysis of mRNA and protein levels of candidate genes encoding the transient outward K(+) current (I(to)) revealed marked reductions in canine cKv4.3 expression in HF in Epi (44% mRNA, 39% protein), Mid (52% mRNA, 34% protein), and Endo (49% mRNA, 73% protein) layers and a paradoxical enhancement (41% Epi, 97% Mid, 113% Endo) in cKv1.4 protein levels, without significant changes in Kv channel-interacting protein cKChIP2 expression. Expression of cKir2.1, the gene underlying inward rectifier K(+) current (I(K1)), was unaffected by HF at mRNA and protein levels despite significant reduction in I(K1), whereas canine ether-a-go-go-related gene (cERG), which encodes the rapidly activating component of the delayed rectifier current (I(K)), exhibited increased protein expression. HF was not accompanied by significant changes in cKvLQT1 or cMinK mRNA and protein levels. These data indicate that 1) downregulation of I(to) in HF is associated with decreased cKv4.3 and not cKv1.4 or cKChIP2, and 2) alterations in both the rapidly activating and slowly activating components of I(K) as well as I(K1) in nonischemic dilated cardiomyopathy are not caused by changes in either transcript or immunoreactive protein levels of relevant channel subunits, which suggests posttranslational modification of these currents by HF.
Preparing Starchy Foods Containing Silver Nanoparticles and Evaluating Antimicrobial Activitiy (2013)

Background: Silver has been used from ancient times by humans, and recently nanoparticles of silver have been used in many aspects of human life including as a potent antibacterial agent. Objectives: In the current study a completely green method to prepare silver nanoparticles is reported. Two types of starches (potato and corn starches) were used to produce and stabilize silver nanoparticles. Antimicrobial activities of prepared nanofoods were investigated. Materials and Methods: Nanosilver particles have been produced using high temperature water containing bulk silver nitrate and starch sources. Presence of nanosilver containing particles and formation of the nanoparticles were confirmed using transmission electron microscopy (TEM) and ultraviolet-visible spectroscopy, respectively. The anti-bacterial activity of emulsions made from nanoparticles containing starches was evaluated by assessing minimum inhibitory concentrations (MIC) against the studied standard, and pathogenic bacteria. Results: Findings of the current study indicated that the size and shape of silver nanoparticles depended on the type of starch. For example for a special type of potato starch the cubic silver nanoparticles were obtained whereas for other types of potato starch and corn starch spherical silver nanoparticles were produced. Nanoparticle sizes were mainly about 20 nm, but ranging from 2-30 nm in different situations. Due to the biocompatibility of starch synthesized silver nanoparticles, this method can be used for medicinal purposes. Both kinds of nanosilver containing starch sources have excellent antibacterial activity. Conclusions: The current study indicated that silver nanoparticles produced using different starches had strong antibacterial activities on the studied standard and pathogenic bacteria including gram positive and gram negative.
Ampicillin Treatment of Intracellular Listeria monocytogenes Triggers Formation of Persistent, Drug-Resistant L-Form Cells (2022)

<i>Listeria monocytogenes</i> is an opportunistic intracellular pathogen causing an infection termed listeriosis. Despite the low incidence of listeriosis, the high mortality rate in individuals at risk makes this bacterium one of the most dangerous foodborne pathogens. Reports about a relapse of infection after antibiotic treatment suggest that the bacteria may be able to evade antibiotic treatment and persist as a dormant, antibiotic-tolerant subpopulation. In this study, we observed intracellular generation of antibiotic-resistant L-forms of <i>Listeria monocytogenes</i> following Ampicillin treatment of <i>Listeria monocytogenes</i> infected cells. Detection and identification of intracellular <i>Listeria</i> L-forms was performed by a combination of fluorescence <i>in-situ</i> hybridization and confocal laser scanning microscopy. Using micromanipulation, it was possible to isolate single intracellular L-form cells that following transfer into fresh medium gave rise to pure cultures. In conclusion, the results obtained here provide strong evidence that antibiotic treatment of infected host cells can induce the formation of L-forms from intracellular <i>Listeria monocytogenes</i>. Furthermore, our results suggest that intracellular L-forms persist inside host cells and that they represent viable bacteria, which are still able to grow and proliferate.
Prediction of Preliminary Maximum Wing Bending Moments Under Discrete Gust (2019)

Many methodologies have been proposed to quickly identify among a very large\nnumber of flight conditions and maneuvers (i.e., steady, quasi-steady and\nunsteady loads cases) the ones which give the worst values for structural\nsizing (e.g., bending moments, shear forces, torques,...). All of these methods\nuse both the simulation model of the aircraft under development and efficient\nalgorithms to find out the critical points of the flight envelope. At the\npreliminary structural design phases detailed models are not available and\nairframe's loads are estimated by empirical relationships or engineering\njudgments. These approximations can induce load uncertainties and may lead to\nexpensive redesign activities through the upcoming detailed sizing process. In\nthe context of preliminary design phase for a weight aircraft variant without\ngeometric change, to overcome this likely drawback, we propose a method based\non the huge and reliable database of an initial aircraft from which the weight\nvariant belongs. More precisely, from the load cases of this initial database,\nresponse surfaces are identified as functions of preliminary parameters (flight\nconditions and structural parameters). Then, these response surfaces are used\nto predict quickly the weight aircraft variant quantities of interest for\npreliminary structural design studies. Although the proposed method can be\nreadily extended to any structural quantity of interest and to any flight\nconditions and maneuvers, it is presented here for the prediction of the\nbending moments due to discrete gust at different locations along a wing span.\n
Liquid Crystal Control of Plasmonic Nanoantenna Arrays (2022)

We demonstrate the active control of resonant plasmonic nanoantenna arrays. This demonstration is done with liquid crystals, surface lattice resonances and quasi-guided modes in aluminum nanoparticle arrays on top of waveguides acting as electrodes
The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells (2023)

The MYC proto-oncogene contributes to the pathogenesis of more than half of human cancers. Malignant transformation by MYC transcriptionally up-regulates the core pre-mRNA splicing machinery and causes misregulation of alternative splicing. However, our understanding of how splicing changes are directed by MYC is limited. We performed a signaling pathway-guided splicing analysis to identify MYC-dependent splicing events. These included an HRAS cassette exon repressed by MYC across multiple tumor types. To molecularly dissect the regulation of this HRAS exon, we used antisense oligonucleotide tiling to identify splicing enhancers and silencers in its flanking introns. RNA-binding motif prediction indicated multiple binding sites for hnRNP H and hnRNP F within these cis-regulatory elements. Using siRNA knockdown and cDNA expression, we found that both hnRNP H and F activate the HRAS cassette exon. Mutagenesis and targeted RNA immunoprecipitation implicate two downstream G-rich elements in this splicing activation. Analyses of ENCODE RNA-seq datasets confirmed hnRNP H regulation of HRAS splicing. Analyses of RNA-seq datasets across multiple cancers showed a negative correlation of HNRNPH gene expression with MYC hallmark enrichment, consistent with the effect of hnRNP H on HRAS splicing. Interestingly, HNRNPF expression showed a positive correlation with MYC hallmarks and thus was not consistent with the observed effects of hnRNP F. Loss of hnRNP H/F altered cell cycle progression and induced apoptosis in the PC3 prostate cancer cell line. Collectively, our results reveal mechanisms for MYC-dependent regulation of splicing and point to possible therapeutic targets in prostate cancers.
Classifier-guided sampling for discrete variable, discontinuous design space exploration: Convergence and computational performance (2014)

A classifier-guided sampling (CGS) method is introduced for solving engineering design optimization problems with discrete and/or continuous variables and continuous and/or discontinuous responses. The method merges concepts from metamodel-guided sampling and population-based optimization algorithms. The CGS method uses a Bayesian network classifier for predicting the performance of new designs based on a set of known observations or training points. Unlike most metamodelling techniques, however, the classifier assigns a categorical class label to a new design, rather than predicting the resulting response in continuous space, and thereby accommodates non-differentiable and discontinuous functions of discrete or categorical variables. The CGS method uses these classifiers to guide a population-based sampling process towards combinations of discrete and/or continuous variable values with a high probability of yielding preferred performance. Accordingly, the CGS method is appropriate for discrete/discontinuous design problems that are ill suited for conventional metamodelling techniques and too computationally expensive to be solved by population-based algorithms alone. The rates of convergence and computational properties of the CGS method are investigated when applied to a set of discrete variable optimization problems. Results show that the CGS method significantly improves the rate of convergence towards known global optima, on average, compared with genetic algorithms.
Electrical properties of the lead lanthanum zirconate titanate (2001)

Abstract This paper reports electrical properties of the lead zirconate titanate system including lead lanthanum zirconate titanate. Some compositions of the lead zirconate titanate system materials have photovoltaic effect, which is applicable to the micro electro-mechanical systems. Sample preparation was carried out in use of the conventional solid state reaction method. Density and dielectric constant were obtained as a suitable value. These samples have the perovskite structure that is confirmed by X-ray diffraction method. The dark conductivity and also photoconductivity are estimated in use of the high-resistance electrometer. Some proposal was shown for the development on the photovoltaic effect from the material view of points.
Traitement et pronostic des syndromes lymphoprolifératifs post-transplantation (1999)

Les syndromes lymphoproliferatifs post-transplantation (SLP-PT) forment un groupe de proliferations lymphoides heterogenes par leurs presentations cliniques et leurs aspects histologiques. Ils representent une des complications potentiellement letales de la transplantation d’organe. Les mecanismes physiopathologiques responsables de l’apparition des SLP-PT ne sont pas encore entierement compris mais font probablement intervenir le deficit immunitaire, les effets oncogeniques des therapies immunosuppressives et le virus d’Epstein-Barr. Les etudes sur l’incidence, le traitement et le pronostic sont limitees par le petit nombre de cas survenant dans chaque centre de transplantation, et par l’absence de classifications fiables. La mortalite globale reste elevee meme si 25 % des patients sont gueris par une simple diminution de l’immunosuppression. Dans les autres cas, divers traitements sont couramment utilises mais la strategie therapeutique optimale ne pourra etre etablie qu’avec l’aide d’etudes multicentriques portant sur un grand nombre de patients, et lorsqu’une classification adequate sera disponible. Les tumeurs monoclonales d’apparition tardive peuvent etre traitees par la chimiotherapie conventionnelle, tandis que les patients atteints de SLP-PT d’apparition precoce positifs pour le virus d’Epstein-Barr peuvent beneficier d’autres approches therapeutiques comme les therapies immunoregulatrices.
Entangled photon transmission from a quantum dot over loop-back fiber in Cambridge network (2019)

Quantum dots are considered to be one of the most important quantum emitters due to their ability of emitting entangled single photons, which have not yet been practically used for large-scale quantum communication. In this work [1], we have realized the transmission of polarization-encoded entangled single photons at the telecommunication O-band emitted from a quantum dot over a loop-back fiber in the Cambridge fiber network. To maintain the polarization, an active feedback system with two classical reference beams is implemented. Stable transmission of high-fidelity (91.3%) entanglement has been achieved over one week, which is a significant step toward the application of quantum dots in quantum networks.
Implementation Details of the Time Division Beacon Scheduling Approach for ZigBee Cluster-Tree Networks (2007)

This technical report describes the implementation details of the Time Division Beacon Scheduling Approach in IEEE 802.15.4/ZigBee Cluster-Tree Networks. In this technical report we describe the implementation details, focusing on some aspects of the ZigBee Network Layer and the Time Division Beacon Scheduling mechanism. This report demonstrates the feasibility of our approach based on the evaluation of the experimental results. We also present an overview of the ZigBee address and tree-routing scheme.
Ecological Shifts in Mediterranean Coralligenous Assemblages Related to Gorgonian Forest Loss (2014)

Mediterranean gorgonian forests are threatened by several human activities and are affected by climatic anomalies that have led to mass mortality events in recent decades. The ecological role of these habitats and the possible consequence of their loss are poorly understood. Effects of gorgonians on the recruitment of epibenthic organisms were investigated by manipulating presence of gorgonians on experimental panels at 24 m depth, for Eunicella cavolinii, and at 40 m depth, for Paramuricea clavata, at two sites: Tavolara Island (Tyrrhenian Sea) and Portofino Promontory (Ligurian Sea). After 4 months, the most abundant taxa on the panels were encrusting green algae, erect red algae and crustose coralline algae at 24 m depth and encrusting brown algae and erect red algae at 40 m depth. Assemblages on the panels were significantly affected by the presence of the gorgonians, although effects varied across sites and between gorgonian species. Species diversity and evenness were lower on panels with gorgonian branches. Growth of erect algae and recruitment of serpulid polychaetes were also affected by the presence of the gorgonians, primarily at Tavolara. Crustose coralline algae and erect sponges were more abundant on E. cavolinii panels at 24 m depth, while encrusting bryozoans were more abundant on P. clavata panels at 40 m depth. Effects of gorgonians on recruited assemblages could be due to microscale modification of hydrodynamics and sediment deposition rate, or by a shading effect reducing light intensity. Gorgonians may also intercept settling propagules, compete for food with the filter-feeders and/or for space by producing allelochemicals. Presence of gorgonians mainly limits the growth of erect algae and enhances the abundance of encrusting algae and sessile invertebrates. Therefore, the gorgonian disappearances may cause a shift from assemblages characterised by crustose coralline algae to filamentous algae assemblages, decreasing complexity and resilience of coralligenous bioconstructions.
Crystalline phases at the <i>p</i>- to <i>n</i>-type transition in Cu-ternary semiconducting films (1996)

We report here a study of the Raman spectra of ternary Cu–In–S and Cu–In–Se polycrystalline film compounds as a function of the x=[In]/{Cu]+[In]} ratio. Using these spectra we were able to identify, with high resolution in x, the phases present in the films. We found that the single phase of chalcopyrite CnInSe2 exists over the fairly wide composition range of 0.48⩽x⩽0.55, and that the lattice disorder increases with the increase of In content. No such single phase range was found for the Cu–In–S films. Considering the electrical properties of these materials around x=0.5, it is concluded that the native defect model accounts for the electrical properties of the Cu–In–Se films but does not account simply for the electrical properties of the Cu–In–S films.
Author response: The NFκB-inducing kinase is essential for the developmental programming of skin-resident and IL-17-producing γδ T cells (2015)

Our bodies are protected from infection and disease by several different types of immune cells. Gamma delta T cells are unusual in that they only make up a small proportion of the immune cells of the body, yet are present in many different animal species. These peculiar T cells are primarily found in the tissues that line the body (such as the skin, lung and gut) and are part of the first stage of the immune response that occurs when an invading microbe enters the body. Gamma delta T cells, like all other T cells, develop in an organ called the thymus, which is found in the chest. Although several complex signaling pathways have been identified that help specific immune cells to develop, there are still many open questions about them. It is also unclear if other cells in the thymus influence how gamma delta T cells develop. Mair et al. engineered mouse embryos that could not produce a signaling molecule known as NIK in certain subsets of their cells. This revealed that NIK is important for a structural cell in the thymus to instruct the early stages of gamma delta T cell development. However, gamma delta T cells themselves do not need to be able to produce NIK or the signaling pathway that it triggers. Further work will focus on discovering the exact way in which the structural cells of the thymus interact with gamma delta T cells. This will help us understand better how developing immune cells are ‘educated’ in the thymus so that they are able to work effectively in the adult.
Supplementary Tables S1-6 from &lt;i&gt;Sleeping Beauty&lt;/i&gt; Insertional Mutagenesis in Mice Identifies Drivers of Steatosis-Associated Hepatic Tumors (2023)

&lt;p&gt;Supplementary tables detailing qRT-PCR primer sequences (S1), IHC antibodies (S2), and parameters for histological stain quantification (S3-6) described in methods.&lt;/p&gt;
Calibration of multi-axis MEMS force sensors using the shape from motion method (2006)

This paper presents a new design of a two-axis MEMS (microelectromechanical systems) capacitive force sensor with strict linearity and a new sensor calibration method for micro-sensors. Precise calibration of multi-axis micro force sensors is difficult for several reasons, including the need to apply many known force vectors at precise orientations at the micro force scale, and the risk of damaging the small, fragile MEMS device. In this paper the shape from motion method is introduced for micro force sensors resulting in a rapid and effective calibration technique. Structural-electrostatic coupled field simulations are conducted in order to optimize the sensor design, which is calibrated with the shape from motion method as well as the least squares method for comparison purposes. Calibration results demonstrate that the shape from motion method is an effective, practical, and accurate method for calibrating multiaxis micro force sensors
Synthesis and Redox Property of Polypeptides Containing <scp>l</scp>-Ferrocenylalanine (1997)

Abstract An optically-active redox amino acid, l-ferrocenylalanine was synthesized. The amino acid was incorporated into polypeptides in the form of a single l-ferrocenylalanine unit or a l-ferrocenylalanyl-l-ferrocenylalanine unit. Those polypeptides showed reversible redox property on the cyclic voltammetry.
Haploidentical hematopoietic stem cell transplantation for paediatric high‐risk <scp>T</scp>‐cell acute lymphoblastic leukaemia (2016)

Paediatric HR T-cell ALL demonstrates dismal prognosis with chemotherapy, and poor outcomes could be improved with allo-SCT. HID-SCT is an almost immediately available choice; however, few studies have focused on the outcomes of HID-SCT for paediatric HR T-ALL. Forty-eight consecutive HR T-ALL children who underwent HID-SCT were included. Survival outcomes and factors predictive of outcomes were retrospectively analysed. Of the 48 patients, 35 were in CR1, 10 in CR2, and three in relapse. The cumulative incidence of grade 3/4 aGVHD was 10.4% and that of extensive cGVHD was 28.4%. The CIR at three yr was 30.8% and that of NRM at three yr was 14.7%. At a median follow-up of 20.0 (range 2.5-124.2) months, the three-yr LFS was 54.4%. Children who received transplants during CR1 had a better LFS (65.7% vs. 26.0%, p = 0.008) and a lower relapse rate (19.8% vs. 56.7%, p = 0.014) compared to those during non-CR1. HID-SCT is feasible for HR T-ALL children, and survival outcomes are better when performed in CR1 compared to non-CR1. Prospective clinical trials would be needed to confirm that.