gebhart/patrepeval huggingface dataset:
Power Line Communication Degradation caused by Surge Protective Devices (2015)

We have already reported (3)-( Not only the capacitance of the varistor but also the inductance of the varistor and wiring of SPD cause LC series resonance and attenuate signal level at the resonant frequency. In this paper, we found that there is a close relationship among capacitance, maximum current, size of disk, and varistor voltage. The inductance is the sum of SPDs themselves and wiring connecting SPDs to AC power lines. Therefore how to install SPDs and connect them to Protection Earth (PE) is important. Typical varistor type SPDs that have 1000 pF to 14000pF and wiring less than 50 cm will have resonant frequency somewhere between 2 MHz to 30 MHz. We propose practical information to select and install SPDs on AC power lines, and to estimate PLC signal degradation.
Noninvasive quantitative imaging of historical parchments by polarization-resolved SHG microscopy (2021)

Advanced nonlinear optical (NLO) microscopy enables quantitative in situ mapping of parchment degradation at the micrometer scale. We show that measurements of the ratio of fluorescence over second harmonic generation (SHG) signals probes severe collagen degradation and could help to identify the parchments most at risk, close to the irreversible collagen denaturation into gelatin. Conversely, the anisotropy parameter obtained from polarization-resolved SHG measurements probes the earlier stages of degradation. This approach is first validated by comparing NLO quantitative parameters to thermal measurements by differential scanning calorimetry on artificially altered contemporary parchments. We then analyze invaluable parchments from the Middle Ages.
Architectural dependability evaluation with Arcade (2008)

This paper proposes a formally well-rooted and extensible framework for dependability evaluation: Arcade (architectural dependability evaluation). It has been designed to combine the strengths of previous approaches to the evaluation of dependability. A key feature is its formal semantics in terms of input/output-interactive Markov chains, which enables both compositional modeling and compositional state space generation and reduction. The latter enables great computational reductions for many models. The Arcade approach is extensible, hence adaptable to new circumstances or application areas. The paper introduces the new modeling approach, discusses its formal semantics and illustrates its use with two case studies.
Enantioselective Intramolecular Benzylic CH Bond Amination: Efficient Synthesis of Optically Active Benzosultams (2011)

'Salen' along: the iridium(III)-salen complex 1 efficiently catalyzes the title reaction of 2-ethylbenzenesulfonyl azides to give five-membered sultams with high enantioselectivity. Other 2-alkyl-substitued substrates lead to five- and six-membered sultams with high enantioselectivity; the regioselectivity depends upon the substrate and the catalyst used. EDG=electron-donating group.
Characteristics of HPV infection over time in European women who are HIV‐1 positive (2012)

A wide diversity of HPV types was evident, and multiple infections were common. Detection or persistence of any HR-HPV was associated with a very low incidence of subsequent high-grade disease.
Rapid Prototyping of CMP Floorplans: A Technical Report (2012)

The Computer Architecture literature is now replete with papers concerned with the change in architectural direction from ever more complex single cores to single chip multi-core designs. Along with this opportunity come major challenges. Among them is the sheer size of the space of possible designs. The investigation of this space is far from complete. What is needed to aid in this task is an integrated suite of tools that provides support throughout the design life-cycle, from early prototyping to final design. Here we present a floorplan tool targeted towards early prototyping of pre-RTL CMP design concepts. As such, it acts as a complement to traditional floorplan tools that are more appropriate later in the design process. Early phase CMP design investigations into the distribution of power and temperature, pin allocation, core/cache cluster size, and NoC design trade-offs are examples of experiments that can benefit from CMP layout information without many of the design details needed to drive a traditional floorplanner. We use two such studies to validate the benefit of the tool in rapid prototyping. The floorplan is specified using a model similar to that supported by GUI toolkits such as Java Swing or Windows Presentation Foundation. The floorplan design is comprised of a hierarchy of components placed within containers that provide a variety of layout services. These services include support for geographic hints for component placement, generalized grid layouts, and other layout algorithms. The tool can also be integrated with other tools in the suite by absorbing area information from tools such as McPAT, and producing output for ingestion by tools such as HotSpot. In addition, the current services can act as the basis for building more specific layout algorithms such as those targeting a certain type of NoC configuration, cache partitioning strategy, or SIMD design. Finally, the architecture is flexible enough to allow for the inclusion of a traditional floorplan tool such as ParquetFP to support detailed floorplanning once enough design information is available. This tool, which we call ArchFP, can be downloaded from http://lava.cs.virginia.edu/archfp.
PicoCube (2008)

The PicoCube is a 1 cm3 sensor node using harvested energy as its source of power. Operating at an average of only 6uW for a tirepressure application, the PicoCube represents a modular and integrated approach to the design of nodes for wireless sensor networks. It combines advanced ultra-low power circuit techniques with system-level power management. A simple packaging approach allows the modules comprising the node to fit into 1 cm3 in a reliable fashion.
NEW MEANS OF GENERATING A LOW-FREQUENCY SINE-WAVE SIGNAL WITH A LOW HARMONIC DISTORTION COEFFICIENT AND THE PROBLEMS OF PROVIDING METROLOGICAL BACKUP RADIO MEASUREMENTS (2011)

The problem of constructing precision apparatus for generating a sine-wave signal based on the direct digital synthesis method is considered. A block diagram and the basic technical characteristics are presented, and the individual units of the G3-135, G3-136, and G3-137 generators, the harmonic distortion coefficients of which are less than 0.001%, are described. The results of tests of the generators at the The development of radio electronics, communications systems, instrument construction and the requirements of the defense industry in Russia require the design of new measuring systems, which generate a sine-wave signal of precision form with a harmonic distortion coefficient of 0.001% or less. Instruments of the G3 group, namely, G3-131, RG3-124, G3-123, G3-122, G3-121, G3-120, G3-119, G3-113, and G3-112, having a harmonic distortion coefficient of greater than 0.02% (G3-121), and in the majority of these of not less than 0.1%, are now obsolete and no longer in production. It should be noted that the G3-118 generator, which is also no longer produced, has a harmonic distortion coefficient that does not exceed 0.002% in the 200 Hz - 10 kHz band. At the same time, the present state of signal digital processing techniques provides the means for solving the problem of generating signals of precision form (with a low harmonic distortion coefficient) using direct digital synthesis (DDS). When developing new technical systems for generating signals of precision form, the problem arises of checking the measuring instruments employed for measuring harmonic distortion coefficients of less than 0.003%. The State Checking Scheme for instruments for measuring the harmonic distortion coefficient, available in Russia at the present time (1, 2), estab- lishes the State Primary Standard for reproducing and storing the unit of harmonic distortion coefficient K h in the range 0.003-100%, while the harmonic distortion coefficient of the output signals of the generators lie in the range 0.005-1%. Hence it is an urgent problem to construct new precision sine-wave generators and to develop methods of checking them. A Method of Direct Digital Synthesis and a Block Diagram of the Generator. Among the methods of synthe-
${N}$ -Continuous SC-FDMA and Its Polarized Transmission and Reception (2017)

This paper investigates the application of N-continuous spectral projection precoding design to single-carrier frequency-division multiple access (SC-FDMA). It first considers a general orthogonal projection-based precoded system with an improved iterative receiver and analyzes its ultimate performance in an additive white Gaussian noise channel, both in terms of achievable throughput and symbol-error rates. For N-continuous SC-FDMA, the distribution of the symbol errors is very much asymmetric; a few base pulses carry the lion share of the self-induced interference, resulting in a zero throughput. We show that an optimized transmission and reception scheme based on a polarized use of the base pulses can satisfactorily deal with this asymmetry, and the end-to-end throughput can be recovered to be close to optimal. Applying a similar scheme to N-continuous OFDM enables also an improved performance in the high-SNR regime, where the interference effect strikes the most.
Histone deacetylase inhibitors enhance oncolytic herpes simplex virus therapy for malignant meningioma (2022)

Approximately 20% of meningiomas are not benign (higher grade) and tend to relapse after surgery and radiation therapy. Malignant (anaplastic) meningioma (MM) is a minor subset of high-grade meningioma that is lethal with no effective treatment options currently. Oncolytic herpes simplex virus (oHSV) is a powerful anti-cancer modality that induces both direct cell death and anti-tumor immunity, and has shown activity in preclinical models of MM. However, clinically meaningful efficacy will likely entail rational mechanistic combination approaches. We here show that epigenome modulator histone deacetylase inhibitors (HDACi) increase anti-cancer effects of oHSV in human MM models, IOMM-Lee (NF2 wild-type) and CH157 (NF2 mutant). Minimally toxic, sub-micromolar concentrations of pan-HDACi, Trichostatin A and Panobinostat, substantively increased the infectability and spread of oHSV G47Δ within MM cells in vitro, resulting in enhanced oHSV-mediated killing of target cells when infected at low multiplicity of infection (MOI). Transcriptomics analysis identified selective alteration of mRNA processing and splicing modules that might underlie the potent anti-MM effects of combining HDACi and oHSV. In vivo, HDACi treatment increased intratumoral oHSV replication and boosted the capacity of oHSV to control the growth of human MM xenografts. Thus, our work supports further translational development of the combination approach employing HDACi and oHSV for the treatment of MM.
Rocket Engine Test System for Development of Novel Propulsion Technologies (2019)

A 150 lbf thrust class, modular, bi-propellant, rocket engine/gas-generator and supporting test infrastructure has been developed in a cooperative effort between Sandia National Laboratories and the New Mexico Institute of Mining and Technology’s (NMIMT’s) Energetic Materials Research and Testing Center (EMRTC). This modular test engine design consists of a head end fuel-oxidizer injector, a spark ignition gaseous H2/O2 torch igniter, combustion chamber and nozzle module. This robust design allows for rapid configuration changes as well as economical repair should hardware become damaged in testing. The engine interfaces with a permanently installed pressurizing system capable of delivering liquid nitrous oxide and a variety of liquid fuels for both rocket engine development and propellant performance evaluation. The regulated high pressure systems allow for delivery of liquefied gases above their saturation pressure as well as allowing for high pressure rocket engine/gas-generator operation. The facility test cell houses a 1 ton thrust capacity test stand leaving room for larger scale engine development.
High-Mobility Holes in Dual-Gated WSe<sub>2</sub> Field-Effect Transistors (2015)

We demonstrate dual-gated p-type field-effect transistors (FETs) based on few-layer tungsten diselenide (WSe2) using high work-function platinum source/drain contacts and a hexagonal boron nitride top-gate dielectric. A device topology with contacts underneath the WSe2 results in p-FETs with ION/IOFF ratios exceeding 10(7) and contacts that remain ohmic down to cryogenic temperatures. The output characteristics show current saturation and gate tunable negative differential resistance. The devices show intrinsic hole mobilities around 140 cm(2)/(V s) at room temperature and approaching 4000 cm(2)/(V s) at 2 K. Temperature-dependent transport measurements show a metal-insulator transition, with an insulating phase at low densities and a metallic phase at high densities. The mobility shows a strong temperature dependence consistent with phonon scattering, and saturates at low temperatures, possibly limited by Coulomb scattering or defects.
Big Data Computing and Clouds: Challenges, Solutions, and Future Directions (2013)

This paper discusses approaches and environments for carrying out analytics on Clouds for Big Data applications. It revolves around four important areas of analytics and Big Data, namely (i) data management and supporting architectures; (ii) model development and scoring; (iii) visualisation and user interaction; and (iv) business models. Through a detailed survey, we identify possible gaps in technology and provide recommendations for the research community on future directions on Cloud-supported Big Data computing and analytics solutions.
Granulocyte/macrophage‐colony stimulating factor and interleukin‐4 expand and activate type‐1 dendritic cells (DC1) when administered <i>in vivo</i> to cancer patients (2003)

Two rare populations of cells with the features of dendritic cell precursors (preDC) can be identified in human peripheral blood. PreDC1 are HLA-DR+/CD11c+ cells which mature into DC1 capable of stimulating Th1 responses. In contrast, preDC2 are HLA-DR+/CD11c-/CD123+ cells that promote Th2 responses when matured into DC2. We hypothesized that administration of GM-CSF and IL-4, growth factors for DC1, would specifically augment the number and function of circulating DC1 in vivo. Patients with advanced metastatic cancer were treated with GM-CSF (2.5 microg/kg/day) and IL-4 (4 or 6 microg/kg/day) for 7 days. Cytokine administration at the highest IL-4 dose produced an average 2.3-fold increase in preDC2 number, but a 6.5-fold increase in preDC1, resulting in an increased ratio of circulating preDC1:preDC2 from 1.4:1 pre-treatment to 4.3:1 after cytokine therapy. DC1 precursors identified after in vivo therapy were larger, more complex and expressed higher levels of HLA-DR, CD11c and CD80 than pre-treatment cells. DC1 isolated from the peripheral blood of patients receiving GM-CSF/IL-4 therapy demonstrated MLR activity comparable to that of monocyte-derived DC generated in vitro from the patients' pre-treatment blood using GM-CSF and IL-4. We conclude that systemic administration of GM-CSF and IL-4 preferentially expands and matures the preDC1 population in vivo. These effects correlate with antigen-presenting activity, providing a mechanism by which systemic GM-CSF and IL-4 might stimulate anti-tumor immunity in vivo.
&lt;title&gt;Fitting of surfaces to scattered data&lt;/title&gt; (1992)

Reconstruction of shapes from partial information is a problem arising in many scientific and engineering applications. We present a method for reconstructing a two-dimensional manifold from an unstructured collection of sampled points. The algorithm consists of two major steps. In the first step, we estimate the topological type of the manifold and also obtain a crude estimate of its geometry. In the second step, we improve the fit of the estimate to the data points, while keeping the topological type fixed.
Transition ligne micro-ruban / guide d’ondes de 55 à 95 GHz par l’ajout d’une pointe diélectrique et d’une section à double moulure (2017)

National audience
An MR-compatible printed Yagi-Uda antenna for a phased array hyperthemia applicator (2013)

Magnetic resonance (MR) thermometry guided hyperthermia has a strong potential to make the heat delivery to the tumor more selective. For head and neck hyperthermia, the Hypercollar was developed that allows focused, tumor-conformal, heating. To replace current dose assessment using invasive probes, an MR compatible Hypercollar is being designed. The conducting backplane of current patch antennas make MR imaging impossible. In this study, we developed a printed Yagi-Uda antenna for the 433 MHz ISM band that is inherently MR compatible. Proper design makes it very small in dimensions and allows it to work without a backplane. Parameter studies using simulation tools were performed to validate its properties under clinical conditions. Subsequently, a prototype was manufactured and reflection coefficient was measured and compared to simulations. Simulations and measurements show a good agreement and indicate that the antenna meets with the investigated specifications.
Wavelength and polarization selective multi-band tunnelling quantum dot detectors (2007)

Abstract The reduction of the dark current without reducing the photocurrent is a considerable challenge in developing far-infrared (FIR)/terahertz detectors. Since quantum dot (QD) based detectors inherently show low dark current, a QD-based structure is an appropriate choice for terahertz detectors. The work reported here discusses multi-band tunnelling quantum dot infrared photo detector (T-QDIP) structures designed for high temperature operation covering the range from mid-to far-infrared. These structures grown by molecular beam epitaxy consist of a QD (InGaAs or InAlAs) placed in a well (GaAs/AlGaAs) with a double-barrier system (AlGaAs/InGaAs/AlGaAs) adjacent to it. The photocurrent, which can be selectively collected by resonant tunnelling, is generated by a transition of carriers from the ground state in the QD to a state in the well coupled with a state in the double-barrier system. The double-barrier system blocks the majority of carriers contributing to the dark current. Several important properties of T-QDIP detectors such as the multi-colour (multi-band) nature of the photoresponse, the selectivity of the operating wavelength by the applied bias, and the polarization sensitivity of the response peaks, are also discussed.
Cylindrical Magnetic Nanowires Applications (2021)

Cylindrical magnetic nanowires (NWs) feature unique properties, which make them attractive for fundamental research and novel applications. These 1-D structures introduce a pronounced shape anisotropy that together with material selection can strongly affect the magnetic properties and can be tuned by incorporating segments of different materials or diameters along the length. They attract a large interest in the scientific community, ranging from physicists to material scientists to bioengineers. Consequently, these NWs are developed for and used in very diverse applications in medicine, biology, data and energy storage, catalysis, or microwave electronics, among others. In this review, we investigate the most active emerging applications of cylindrical NWs grown in alumina templates by electrochemical deposition. This method has several key features, including low cost and a high level of control over the design. A fundamental property that distinguishes those applications is the operating frequency, which we chose to apply as an underlying structure for this review. With this, we attempt to provide a wide and organized view of applications based on cylindrical magnetic NWs with a focus on tailored physical and chemical properties.
Development of a Nuclear Transformation System for Oleaginous Green Alga Lobosphaera (Parietochloris) incisa and Genetic Complementation of a Mutant Strain, Deficient in Arachidonic Acid Biosynthesis (2014)

Microalgae are considered a promising source for various high value products, such as carotenoids, ω-3 and ω-6 polyunsaturated fatty acids (PUFA). The unicellular green alga Lobosphaera (Parietochloris) incisa is an outstanding candidate for the efficient phototrophic production of arachidonic acid (AA), an essential ω-6 PUFA for infant brain development and a widely used ingredient in the baby formula industry. Although phototrophic production of such algal products has not yet been established, estimated costs are considered to be 2-5 times higher than competing heterotrophic production costs. This alga accumulates unprecedented amounts of AA within triacylglycerols and the molecular pathway of AA biosynthesis in L. incisa has been previously elucidated. Thus, progress in transformation and metabolic engineering of this high value alga could be exploited for increasing the efficient production of AA at competitive prices. We describe here the first successful transformation of L. incisa using the ble gene as a selection marker, under the control of the endogenous RBCS promoter. Furthermore, we have succeeded in the functional complementation of the L. incisa mutant strain P127, containing a mutated, inactive version of the delta-5 (Δ5) fatty acid desaturase gene. A copy of the functional Δ5 desaturase gene, linked to the ble selection marker, was transformed into the P127 mutant. The resulting transformants selected for zeocine resistant, had AA biosynthesis partially restored, indicating the functional complementation of the mutant strain with the wild-type gene. The results of this study present a platform for the successful genetic engineering of L. incisa and its long-chain PUFA metabolism.
Weak Interactions between Poly(ether imide) and Carbon Dioxide: A Multiscale Investigation Combining Experiments, Theory, and Simulations (2022)

This contribution aims at an understanding, at a molecular scale, of the state of CO2 molecules absorbed in glassy poly(ether imide) (PEI). This issue has been challenged by combining different approaches that tackle the problem from both the experimental and the theoretical viewpoints and providing a comprehensive physicochemical picture. In situ FTIR spectroscopy and gravimetry were exploited to gather relevant experimental information, while molecular dynamics (MD), density functional theory (DFT), and statistical thermodynamics approaches were used to model the behavior of the binary system at different scales. Based on the findings of FTIR spectroscopy and on DFT and MD calculations, it was determined that, among the possible interaction configurations, some are prevailing. In particular, the carbon atom of carbon dioxide molecules establishes relatively weak interactions prevalently with the carbonyl groups of PEI. A quantitative estimate of such interaction has been provided by MD calculations. The system was also analyzed using a lattice fluid model, specifically developed to deal with sorption of low molecular weight compounds in glassy polymers, that is rooted on statistical thermodynamics, determining the values of the isosteric heat of sorption and carbon-dioxide-polymer interaction energy. Finally, experimental data of CO2-PEI mutual diffusivity have been interpreted using a semiempirical theoretical model accounting for the effects of the penetrant concentration, of energy barriers associated with the occurrence of an effective diffusive jump, and of a thermodynamic factor.