gebhart/patrepeval huggingface dataset:
Search for dark matter produced in association with a single top quark or a top quark pair in proton-proton collisions at $$ \sqrt{s}=13 $$ TeV (2019)

A bstract A search for dark matter produced in association with top quarks in proton-proton collisions at a center-of-mass energy of 13 TeV is presented. The data set used corresponds to an integrated luminosity of 35.9 fb −1 recorded with the CMS detector at the LHC. Whereas previous searches for neutral scalar or pseudoscalar mediators considered dark matter production in association with a top quark pair only, this analysis also includes production modes with a single top quark. The results are derived from the combination of multiple selection categories that are defined to target either the single top quark or the top quark pair signature. No significant deviations with respect to the standard model predictions are observed. The results are interpreted in the context of a simplified model in which a scalar or pseudoscalar mediator particle couples to a top quark and subsequently decays into dark matter particles. Scalar and pseudoscalar mediator particles with masses below 290 and 300 GeV, respectively, are excluded at 95% confidence level, assuming a dark matter particle mass of 1 GeV and mediator couplings to fermions and dark matter particles equal to unity.
High Accuracy Localization of Long Term Evolution Based on a New Multiple Carrier Noise Model (2014)

A high accuracy localization technique using Long Term Evolution (LTE) based on a new and accurate multiple carrier noise model has been developed. In the noise consideration, the LTE multiple carriers phase noise has been incorporated so that a new and accurate noise model is achieved. An experiment was performed to characterize the phase noise of carriers at 2 GHz. The developed noise model was incorporated into LTE localization analysis in a high traffic area in Hong Kong to evaluate the accuracy of localization. The evaluation and analysis reveals that the new localization method achieves an improvement of about 10% accuracy comparing to existing widely adopted schemes.
Figure S3B from Chronic Lymphocytic Leukemia with Mutated IGHV4-34 Receptors: Shared and Distinct Immunogenetic Features and Clinical Outcomes (2023)

&lt;p&gt;CLL with mutated IGHV4-34 receptors: shared and distinct clinical outcomes. B. IgG subsets #4 and #16 displayed significantly longer TTFT (p=0.00038) compared to M-CLL cases utilizing IGHV genes other than IGHV4-34.&lt;/p&gt;
Chrysophanic acid reduces testosterone-induced benign prostatic hyperplasia in rats by suppressing 5α-reductase and extracellular signal-regulated kinase (2016)

Benign prostatic hyperplasia (BPH) is one of the most common chronic diseases in male population, of which incidence increases gradually with age. In this study, we investigated the effect of chrysophanic acid (CA) on BPH. BPH was induced by a 4-week injection of testosterone propionate (TP). Four weeks of further injection with vehicle, TP, TP + CA, TP + finasteride was carried on. In the CA treatment group, the prostate weight was reduced and the TP-induced histological changes were restored as the normal control group. CA treatment suppressed the TP-elevated prostate specific antigen (PSA) expression. In addition, 5α-reductase, a crucial factor in BPH development, was suppressed to the normal level close to the control group by CA treatment. The elevated expressions of androgen receptor (AR), estrogen receptor α and steroid receptor coactivator 1 by TP administration were also inhibited in the CA group when compared to the TP-induced BPH group. Then we evaluated the changes in three major factors of the mitogen-activated protein kinase chain during prostatic hyperplasia; extracellular signal-regulated kinase (ERK), c-Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38). While ERK was elevated in the process of BPH, JNK and p38 was not changed. This up-regulated ERK was also reduced as normal by CA treatment. Further in vitro studies with RWPE-1 cells confirmed TP-induced proliferation and elevated AR, PSA and p-ERK were all reduced by CA treatment. Overall, these results suggest a potential pharmaceutical feature of CA in the treatment of BPH.
Modulating Silicon Resonators beyond the Linewidth Limit (2013)

We overcome the resonance linewidth limit in silicon ring modulators using photonic transitions between neighboring resonances. As an example, we demonstrate a silicon ring modulated at &gt;20 GHz beyond its resonance linewidth of 11.5 GHz.
Investigation of Thermal Quench Characteristic in the HTS Bi-2223 Racetrack Coil (2008)

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> The thermal stability and quench propagations are one of the most fundamental issues for the High Temperature Superconducting (HTS) coil. Superconductivity is confined within the phase surface bounded by magnetic field, temperature, and current. Of these three parameters, the temperature is neither completely controllable, nor predictable, because the energy stored in the magnet, can easily be converted into heat up setting the thermal equilibrium within the winding. Therefore, in HTS coil operation, the temperature stability or more generally the thermal behavior of the conductor is the most important. In this paper, a HTS double racetrack pancake coil was prepared to examine the thermal stability, quench propagation and minimum quench energy (MQE). HTS coil was wound using the AMSC Bi-2223. The experimental results are discussed in this paper. </para>
Performance of super‐SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines (2014)

As a direct consequence of the high diversity of the aggressive blood cancer acute myeloid leukemia (AML), proteomic samples from patients are strongly heterogeneous, rendering their accurate relative quantification challenging. In the present study, we investigated the benefits of using a super-SILAC mix of AML derived cell lines as internal standard (IS) for quantitative shotgun studies. The Molm-13, NB4, MV4-11, THP-1, and OCI-AML3 cell lines were selected for their complementarity with regard to clinical, cytogenetic, and molecular risk factors used for prognostication of AML patients. The resulting IS presents a high coverage of the AML proteome compared to single cell lines allied with high technical reproducibility, thus enabling its use for AML patient comparison. This was confirmed by comparing the protein regulation between the five cell lines and by applying the IS to patient material; hence, we were able to reproduce specific functional regulations known to be related to disease progression and molecular genetic abnormalities. The MS proteomics data have been deposited to the ProteomeXchange Consortium (http://proteomecentral.proteomexchange.org) via the PRIDE partner repository with the dataset identifier PXD000441.
The Jahn–Teller effect in the photoelectron spectrum of iron pentacarbonyl (1981)

High quality photoelectron spectra of gaseous Fe(CO)5 excited by HeI, HeII, and ArI photons have been obtained. Major attention is focused on the primarily metal 3d ionizations, which occur in the binding energy region from 7 to 11 eV. Ionization to the 2E′ positive ion state (centered at 8.6 eV) clearly shows the effects of Jahn–Teller distortions in the positive ion. This ionization results in two ionization bands of approximately equal intensity and shape separated by 0.38 eV at room temperature. These bands broaden and the splitting increases to 0.47 eV at 473 °K. Ionization to the 2E″ positive ion state, centered at 9.9 eV, is much less influenced by the Jahn–Tellar effect. There is no discernable splitting of this band at room temperature. These observations are discussed in terms of the electronic structure and bonding of Fe(CO)5. Simple model calculations of the energies of the doubly degenerate electronic states in relation to the appropriate doubly degenerate normal vibrational modes are used to investigate the splitting. The magnitudes of the 2E′ and 2E″ splittings are reproduced very well, and the temperature dependence is reproduced within experimental error. It is found that the vibrational motion primarily responsible for the splitting is a low frequency OC–Fe–CO bending in the equatorial plane. This bending is found in two normal modes, one of which is closely related to the Berry pseudorotation process. The splitting of the 2E′ ionization is clear experimental evidence in the gas phase that the preferred geometry of d7 M(CO)5 is not D3h in this case.
Temperature‐programmed microcolumn liquid chromatography/mass spectrometry (1992)

Abstract A temperature‐programmed microcolumn liquid chromatography/mass spectrometry (LC/MS) system has been developed as a practical alternative to conventional solvent‐programmed LC/MS. Good reproducibility of solute retention was achieved in a specially modified oven that permitted linear temperature programming between 40 and 100°C at rates of 0.1 to 0.5°C min −1 . Through theoretical modelling studies performed under isocratic and isothermal conditions, the optimum separation under temperature‐programmed conditions was rapidly and accurately predicted. This method enabled the complete resolution of saturated and unsaturated fatty acids in a fish oil dietary supplement with identification from their characteristic fragmentation patterns under electron‐impact MS conditions. The mass spectra from the LC/MS system correlated very well with those from a standard reference library to facilitate spectral searching methods.
Fabrication of bio-based epoxy–clay nanocomposites (2013)

Epoxy–clay nanocomposites derived from renewable soybean oils and organo modified montmorillonite clay were prepared. Improved efficiency and performance were achieved through application of new, low viscosity, glycidyl esters of epoxidized fatty acids (EGS) as the epoxy monomer and 4-methyl-1,2-cyclohexanedicarboxylic anhydride as the comonomer. Tensile testing showed that 1 wt% of clay improved nanocomposite strength and modulus by 22% and 13%, respectively, compared to neat polymer. Tensile modulus could be increased up to 34% by nanocomposite clay without any sacrifice of strength. Three types of dispersion techniques, mechanical stirring, high speed shearing, and ultrasonication, were carried out to disperse the clay directly into the epoxy or anhydride portion of the thermoset system without the need of additional solvent. Dispersion of the clay particles into monomer was assessed by means of solubility parameters and optical and scanning electron microscopies, and quality of dispersion further confirmed by small angle X-ray scattering and transmission electron microscopy. Sonication dispersion of clay into the epoxy portion was needed to optimize the dispersion and exfoliation of clay and the higher mechanical and thermal strength of the nanocomposites. The nanocomposites’ morphologies were a mix of intercalated and exfoliated structures, dependent on the dispersion technique. The optimum tensile strength and glass transition temperatures of the nanocomposites were a function of clay concentration and dispersion morphology.
Program for the Division of Chemical Education: New Orleans, LA, August 22-26, 1999 (1999)

ADVERTISEMENT RETURN TO ISSUEPREVReportNEXTProgram for the Division of Chemical Education: New Orleans, LA, August 22-26, 1999Laura Pence , Harry Pence , and Tom Wildeman Cite this: J. Chem. Educ. 1999, 76, 8, 1041Publication Date (Web):August 1, 1999Publication History Received3 August 2009Published online1 August 1999Published inissue 1 August 1999https://doi.org/10.1021/ed076p1041RIGHTS & PERMISSIONSArticle Views68Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1024 KB) Get e-AlertsSUBJECTS:Chemistry education Get e-Alerts
Continuous vs intermittent imatinib treatment in advanced GIST after one year: A prospective randomized phase III trial of the French Sarcoma Group (2004)

9006 Background: Imatinib (Im) is usually given in advanced GIST until progression or intolerance. Secondary resistance to Im is often related to the clonal expansion of clones with Im insensitive KIT mutations. Whether intermittent administration of Im may prevent the long term emergence of resistant clones is unknown. Methods: BFR14, a prospective multicentric phase III study of continuous vs interrupted imatinib treatment in advanced GIST, was initiated in June 2002. Inclusion criterias were: advanced GIST, expressing KIT or PDGFRa mutation. After 1 year of treatment with Im, patients are randomized between 1) continuous (CONT) or 2 ) interruption (STOP) of Im until progression and restart. Patients declining randomization were followed. Primary endpoint was progression free survival. Early stopping rule in case of high rates of re-progression at 3 months were scheduled after the randomisation of 14 patients (n>5) and 29 pts (n>10). Results: As of December 2003, 159 pts were included: 61% were males, 39% emales (39%), with gastric 27%, small bowel (32%), large bowel (12%), mesenteric (20%), or other primaries (9%). Metastatic sites were: liver (55%), peritoneum (35%), nodes (6%), others (19%). 13% pts experienced immediate progression. At 6 months, CR was achieved in 10%, PR in 42%, SD in 36%, PD in 6%, NE in 6% . 41 SAE were observed in 29 pts. Surgery was perfomed in 6 (4%) pts during the 1st year. As of Dec 15, 46 of the 74 (62%) candidate pts were randomized, 23 in both arms: 0 and 5 (21%) pts have a documented reprogression at 3 months in the CONT and STOP arms respectively; Im reintroduction enabled tumor control in all pts with sufficient follow-up so far. Conclusions: Although the early stopping rule on progression at 3 months was not met in the first 14 pts randomized in the STOP arm of the BFR14 trial, advanced GIST pts stopping Gleevec® experience frequent re-progression at 3 months. Supported by Grants from the Centre L.Bérard, Cancéropole Rhone Alpes and Novartis. Author Disclosure Employment or Leadership Consultant or Advisory Stock Ownership Honoraria Research Funding Expert Testimony Other Remuneration Novartis Novartis
HIP ARTHROSCOPY VS. PHYSICAL THERAPY IN PATIENTS WITH FEMOROACETABULAR IMPINGEMENT: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS (2020)

Introduction: Both physical therapy (PT) and surgery appear to have some efficacy in treating femoroacetabular impingement (FAI). Only recently have high-level evidence studies compared these two options, though results of these randomized controlled trials (RCTs) are contradictory. The purpose of this study was to perform a systematic review and meta-analysis of RCTs comparing PT and surgery in patients with FAI. Methods: A systematic review was performed to identify randomized trials comparing FAI and PT. Data was extracted for demographics, study design, patient reported outcomes (PROs), and study quality/bias. In total, 819 abstracts were reviewed, with three RCTs identified (Griffin 2018, Mansell 2018, and Palmer 2019). All three RCTs reported iHOT-33, while two studies reported HOS ADL and Sport (Mansell 2019 and Palmer 2019). In a random effects meta-analysis, between-group differences in post-intervention scores were assessed using intention-to-treat analysis in each study. Results: All 3 RCTs reported PROs improvement from baseline to follow-up for both PT and surgery. The meta-analysis demonstrated greater improved iHOT-33 outcomes with surgery compared to PT with a mean relative difference of 11.3 (95% CI 1.86-20.73, p=0.014). The meta-analysis for HOS ADL and Sports (two RCTs) similarly demonstrated higher scores with surgery with a mean difference of 3.9 (95% CI -9.6-17.3, p=0.571) and 6.2 (95% CI -6.8-19.2, p=0.347), respectively, though without statistical significance. The quality of two RCTs was assessed as good with minimal bias (Griffin and Palmer). In the third RCT, an extremely high crossover rate may affect its validity (Mansell 2018, 70% crossover from PT to surgery). For instance, HOS ADL outcome based on treatment received, adjusting for Mansell’s crossover rate, favored surgery with a larger mean difference of 12.0 (95% CI 7.5-16.5, p&lt;0.001) (compared to intention-to-treat difference of 3.9). Discussion: In patients with FAI, combined results of three RCTs demonstrate superior outcomes of surgery compared to PT. However, PT can result in improvements in some patients and does not appear to compromise surgical outcomes. Provided that the studies adjusted for certain patient characteristics, further research needs to identify patient characteristics that predict success of non-operative and operative treatment of FAI in specific patient subgroups. [Figure: see text]
Pah enu1 is a mouse model for tetrahydrobiopterin-responsive phenylalanine hydroxylase deficiency and promotes analysis of the pharmacological chaperone mechanism in vivo (2010)

The recent approval of sapropterin dihydrochloride, the synthetic form of 6[R]-l-erythro-5,6,7,8-tetrahydrobiopterin (BH(4)), for the treatment of phenylketonuria (PKU) as the first pharmacological chaperone drug initiated a paradigm change in the treatment of monogenetic diseases. Symptomatic treatment is now replaced by a causal pharmacological therapy correcting misfolding of the defective phenylalanine hydroxylase (PAH) in numerous patients. Here, we disclose BH(4) responsiveness in Pah(enu1), a mouse model for PAH deficiency. Loss of function resulted from loss of PAH, a consequence of misfolding, aggregation, and accelerated degradation of the enzyme. BH(4) attenuated this triad by conformational stabilization augmenting the effective PAH concentration. This led to the rescue of the biochemical phenotype and enzyme function in vivo. Combined in vitro and in vivo analyses revealed a selective pharmaceutical action of BH(4) confined to the pathological metabolic state. Our data provide new molecular-level insights into the mechanisms underlying protein misfolding with loss of function and support a general model of pharmacological chaperone-induced stabilization of protein conformation to correct this intracellular phenotype. Pah(enu1) will be essential for pharmaceutical drug optimization and to design individually tailored therapies.
Two Cases of Hepatosplenic T-Cell Lymphoma in Adolescents Treated for Autoimmune Hepatitis (2016)

We report the first 2 cases of hepatosplenic T-cell lymphoma in adolescents diagnosed with autoimmune hepatitis under long-term treatment with azathioprine. Patients presented with fatigue, hepatosplenomegaly, and pancytopenia. The diagnosis could be confirmed performing biopsies of liver and spleen or bone marrow, which demonstrated infiltration of neoplastic T lymphocytes with the typical phenotype with both markers, CD56+ and TCRγδ+. Thus, these cases emphasize the need to constantly reevaluate the administered dose and duration of thiopurines for autoimmune hepatitis, especially in adolescents.
Learning by Observation and Practice: Towards Real Applications of Planning Systems (2018)

Acquiring knowledge from experts for planning systems is a rather difficult knowledge engineering task, but is essential for any applications of planning systems. This work addresses the issue of automatic acquisition of planning operators. Operators are learned by observing the solution traces of experts agents and by subsequently refining knowledge in a learning-by-doing paradigm. It is domain-independent and assumes minimal requirements for a priori knowledge and expert involvement in order to reduce the burden on the knowledge engineerer and domain experts. Planning operators are learned from these observation sequences in an incremental fashion utilizing a conservative specific-to-general inductive generalization process. In order to refine the new operators to make them correct and complete, the system uses the new operators to solve practice problems, analyzing and learning from the execution traces of the resulting solutions or execution failures. We describe techniques for planning and plan repair with incorrect and incomplete domain knowledge, and for operator refinement through a process which integrates planning, execution, and plan repair. Our learning method is implemented on top of the PRODIGY architecture(Carbonell, Knoblock, &amp; Minton 1990; Carbonell et al. 1992) and is demonstrated in the extended-strips domain(Minton 1988) and a subset of the process planning domain(Gil 1991).
Diagnosing Mania in the Age of DSM-5 (2017)

DSM-5 describes the primary criterion of mania as being "a distinct period of abnormally and persistently elevated, expansive, or irritable mood" and "abnormally and persistently increased goal-directed activity or energy." One of our forefathers of psychiatric phenomenology, Emil Kraepelin, referred to this phenomenon a century ago, suggesting that "increased busyness" was the most striking feature of mania (1). He elegantly described it as follows:
Handling Missing Values in Multivariate Time Series Classification (2018)

Multivariate time series data are littered with missing values across many domains. Often the patterns of missing data points reflect conscious decisions by the data collector, and thus may contain correlations that can be used to more accurately classify the data. Previous works propose machine learning models that are capable of detecting these correlations in order to achieve highly accurate results. We review the literature and identify a rich variety of strategies along the machine learning pipeline for handling missing values, including forward imputation, appending additional missing indicators, and others. We also study different deep learning methods for handling time series data, namely GRU and LSTM cells. We then design an experimental study for investigating the relative effectiveness of different state-of-the-art methods for handling missing values to more fully comprehend the intricacies of missing data. For the experimental evaluation study, we utilize MIMIC-III, a publicly available critical care dataset composed of Electronic Health Records (EHR) for over 58,000 hospital admissions collected at Beth Israel Deaconess Medical Center from 2001 to 2012. In particular, our experimental study compares variety of missingness-aware machine learning methods for predicting patient mortality, a benchmark task for this database. We validate in general that extracting information from missing values indeed improves predictive accuracy, and we observe that GRU and LSTM cells perform comparably with the forward imputation method further impacting the resulting accuracy for both models.
Preparation of Gc protein-derived macrophage activating factor (GcMAF) and its structural characterization and biological activities. (2003)

Our results support the importance of the terminal N-acetylgalactosamine moiety in the GcMAF-mediated macrophage activation cascade, and the existence of constitutive GcMAF in human serum. These preliminary data are important for designing small molecular GcMAF mimics.