gebhart/patrepeval huggingface dataset:
Inbreeding and Immunoglobulin G Concentrations in Cattle (1988)

Immunoglobulin G1 concentration (IgG1) was measured in presuckle colostrum and calf serum obtained at 36 h and at weaning from inbred and straightbred Angus, Brangus, Hereford, Red Angus and Simmental cattle. Sources of variation considered as dam traits examined for IgG1 in colostrum and 36-h calf serum included line of sire, sire within line, age, and linear regression of IgG1 on inbreeding of dam. Only line of sire and inbreeding of dam were significant in the analysis of 36-h calf serum. Sources of variation considered as calf traits examined for IgG1 in calf serum at 36 h and at weaning included line of sire, sire within line, sex of calf, age of dam, and regressions of calf serum IgG1 on inbreeding of the calf and on dam's colostral IgG1. Only sire within line and the regression on dam's colostral IgG1 were significant for calf serum IgG1 at 36 h. Large differences existed in 36-h calf serum IgG1 between sires both within lines and when lines were ignored. Calves with 36-h serum IgG1 of less than 10 mg/ml were two to four times more likely to die before weaning than calves with higher IgG1 levels. The heritability estimates of IgG1 by paternal half-sib analysis were .41 +/- .30 for colostrum measured as a trait of the dam and .56 +/- .25 for 36-h. calf serum and .05 +/- .17 for calf serum at weaning considered as a trait of the calf. These estimates indicate that IgG1 in colostrum and 36-h calf serum could be increased by selection.(ABSTRACT TRUNCATED AT 250 WORDS)
Species-dependent tunneling ionization of weakly bound atoms in the short-wave infrared regime (2020)

Abstract We investigate the intensity- and species-dependent strong-field ionization of alkali metal atoms; sodium, potassium, rubidium and caesium; by intense, few-cycle laser pulses in the short-wave infrared (sw-IR) regime at 1800 nm. The low ionization potential, I p , of these atoms allows us to scale the interaction and study the tunneling regime at sw-IR wavelengths using low intensities and pulse energies. Measurements of above-threshold ionization spectra in the alkali species exhibit distinct differences to rare gas spectra at 800 and 1800 nm. However, pairing the low ionization potential of these atoms with longer wavelengths results in the reemergence of some well-know features of nobel gas spectra in the visible, e.g., the plateau. Our focus lies on the comparison of high-energy rescattered electron yield among the different alkali species. The highly unfavorable plateau scaling known from rare gases at longer wavelengths is successfully circumvented by switching to low- I p targets. In the investigated parameter range, we identify potassium as the most efficient rescatterer. In addition, this paves the way to a carrier-envelope phasemeter operating in the sw-IR/mid-wave IR regime, employing alkali metal atoms as a target.
A comparison of alkyl and nitrosyl coordination in the 18-electron complex allylnitrosylbis(triphenylphosphine)ruthenium and its carbon monoxide adduct (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA comparison of alkyl and nitrosyl coordination in the 18-electron complex allylnitrosylbis(triphenylphosphine)ruthenium and its carbon monoxide adductMichael W. Schoonover and Richard EisenbergCite this: J. Am. Chem. Soc. 1977, 99, 25, 8371–8373Publication Date (Print):December 1, 1977Publication History Published online1 May 2002Published inissue 1 December 1977https://pubs.acs.org/doi/10.1021/ja00467a070https://doi.org/10.1021/ja00467a070research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations16LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Polysaccharide‐Derived Carbons for Polar Analyte Separations (2010)

Abstract Highly mesoporous (Brunauer–Emmett–Teller surface area, S BET &gt; 200 m 2 g −1 ; mesopore volume &gt; 1 cm 3 g −1 ) carbonaceous materials are prepared in a truly sustainable manner, from the naturally occurring polysaccharide alginic acid. This approach yields large mesoporous materials (pore diameter &gt; 14 nm) significantly without the use of a template or carbonization catalyst. The direct thermal decomposition of mesoporous forms of the acidic polysaccharide allows for an extremely flexible material preparation strategy. Materials can be prepared at any desired carbonization temperature (e.g., 200–1000 °C), possessing similar textural properties, but progressively presenting more uniform surface functionality through this temperature range, from more oxygenated surfaces at low temperatures to increasingly aromatic/graphitic‐like surfaces. The high‐temperature material (i.e., 1000 °C), while predominantly amorphous, presents some short range (turbostratic) ordering, providing sufficiently polarizable surfaces on which to perform challenging liquid phase separations of polar sugar analytes.
Online Object Recognition Using CNN-based Algorithm on High-speed Camera Imaging: Framework for fast and robust high-speed camera object recognition based on population data cleansing and data ensemble (2021)

High-speed camera imaging (e.g., 1,000 fps) is effective to detect and recognize objects moving at high speeds because temporally dense images obtained by a high-speed camera can usually capture the best moment for object detection and recognition. However, the latest recognition algorithms, with their high complexity, are difficult to utilize in real-time applications involving high-speed cameras because a vast number of images need to be processed with no latency. To tackle this problem, we propose a novel framework for real-time object recognition with high-speed camera imaging. The proposed framework has the key processes of population data cleansing and data ensemble. Population data cleansing improves the recognition accuracy by quantifying the recognizability and by excluding part of the images prior to the recognition process, while data ensemble improves the robustness of object recognition by merging the class probabilities with multiple images from the object tracking sequence. Experimental results with a real dataset show that our framework is more effective than existing methods.
Transcriptional Dynamics During Human Adipogenesis and Its Link to Adipose Morphology and Distribution (2016)

White adipose tissue (WAT) can develop into several phenotypes with different pathophysiological impact on type 2 diabetes. To better understand the adipogenic process, the transcriptional events that occur during in vitro differentiation of human adipocytes were investigated and the findings linked to WAT phenotypes. Single-molecule transcriptional profiling provided a detailed map of the expressional changes of genes, enhancers, and long noncoding RNAs, where different types of transcripts share common dynamics during differentiation. Common signatures include early downregulated, transient, and late induced transcripts, all of which are linked to distinct developmental processes during adipogenesis. Enhancers expressed during adipogenesis overlap significantly with genetic variants associated with WAT distribution. Transiently expressed and late induced genes are associated with hypertrophic WAT (few but large fat cells), a phenotype closely linked to insulin resistance and type 2 diabetes. Transcription factors that are expressed early or transiently affect differentiation and adipocyte function and are controlled by several well-known upstream regulators such as glucocorticosteroids, insulin, cAMP, and thyroid hormones. Taken together, our results suggest a complex but highly coordinated regulation of adipogenesis.
A Phase 2 Trial of Ibrutinib and Nivolumab in Patients with Relapsed or Refractory Classical Hodgkin’s Lymphoma (2023)

Combined nivolumab and ibrutinib led to a CRR of 29.4% in R/R cHL. Although this study did not meet its primary efficacy endpoint of a CRR of 50%, likely due to enrollment of heavily pretreated patients including over half of who had progressed on prior nivolumab treatment, responses that were achieved with combination ibrutinib and nivolumab therapy tended to be durable even in the case of prior progression on nivolumab therapy. Larger studies investigating the efficacy of dual BTK inhibitor/immune checkpoint blockade, particularly in patients who had previously progressed on checkpoint blockade therapy, are warranted.
Simultaneous Optimal Design of a Spring-Supported Beam for Vibration Control. (1998)

The modeling and formulation of simultaneous optimization problems with mixed 〓2/〓∞ norm objective function are discussed in the paper. They are applied to the simultaneous optimization of the cross-sectional parameters of a spring-supported beam and the parameters of the controller used to actively suppress the vibration of the beam. The weighted sum of 〓2 and 〓∞ norms of the transfer functions from external disturbance to measured outputs is used as the objective function. Simulataneous optimization is realized by iteratively executing structural optimization and controller optimization. Both serial and parallel approaches to combine structural optimization and controller optimization are investigated. The performance of both output and control input is improved significantly after simultaneous optimization. The simulation results show the great potential advantages of simulataneous optimization over tranditional design methods.
Genotypic Variation of the Ability of Root to Penetrate Hard Soil Layers among Japanese Wheat Cultivars (2006)

The hard soil in the field is a major constraint for the cereal production because it mechanically restricts the root expansion and water absorption. The ability of root to penetrate into the hard soil is an important factor affecting yield stability of wheat (Triticum aestivum L.) under hard soil and drought conditions. We investigated the variation in the penetrating ability of roots (PA) among Japanese wheat cultivars and its relationship with other shoot and root characters to acquire basic information to develop the cultivars with a higher PA. The evaluation was conducted by the two experiments using the two groups of cultivars: 1) 43 Hokkaido cultivars in the first experiment, 2) 38 Honsyu, including Shikoku and Kyusyu, cultivars in the second experiment. In each experiment, one seedling of each cultivar was grown in a pot with a disc made of paraffin and Vaseline mixture (PV) as a substitute for the hard soil layer. The number of roots penetrating through the PV disc per plant (NRP), the number of seminal and crown roots reached the PV disc per plant (NRR) and the penetration index (PI = NRP/NRR) of each cultivar were evaluated as the traits related to PA. NRP significantly varied with the cultivar from 4.0 to 29.7 and 3.0 to 22.0 in the first and second experiments, respectively. NRP were significantly correlated with NRR (r=0.644** in the first and r=0.477** in the second experiment) and PI (r=0.863** in the first and r=0.811** in the second experiment), but the relationships between NRR and PI were not significant (r=0.260 in the first and r=0.190 in the second experiment). NRR was significantly correlated with the degree of winter growth habit (requirement of vernalization), root dry weight (DW) above the PV disc, the number of stems and leaf DW in each population. Correlations between PI and other characters were low or not significant. These results indicate that a large genotypic variation exists among Japanese wheat cultivars in NRP, and that PI is a suitable indicator of PA. Cultivars with a high PA detected in this study will be useful genetic resources of wheat to improve the yield stability under drought and hard soil conditions.
Chemical stability of a colorimetric indicator based on sodium alginate thin film and methylene blue dye upon active oxygen species exposure (2019)

Abstract Active oxygen species (AOS) generated in the atmosphere can be applied in various industrial processes owing to their extremely strong oxidative ability. Methylene blue (MB) decolors upon exposure to AOS owing to dye degradation; this property can be used to detect the AOS. To detect AOS with higher oxidative ability, it is necessary to stabilize MB by mixing it with sodium alginate. In our previous work, we showed that the OH * concentration in the AOS increased under the high-humidity condition. Herein, the decolorization mechanism of MB-dyed sodium alginate thin films upon exposure to AOS was elucidated under low- and high-humidity conditions; decolorization was observed only under the latter. We analyzed an MB-dyed sodium alginate thin film indicator to elucidate the chemical reactions occurring as well as the decolorization mechanism generated under the high-humidity condition. We found that the decolorization of the film was caused by MB decomposition upon exposure to the AOS generated under the high-humidity condition.
A Just-Noticeable Distortion (Jnd) Profile For Balanced Multiwavelets (2005)

Publication in the conference proceedings of EUSIPCO, Antalya, Turkey, 2005
HIV Vaccines and Prevention in a World Without Mary Lou Clements-Mann and Jonathan Mann (1999)

1Director, Center for Vaccine Development, University of Maryland School of Medicine Baltimore, Maryland, U.S.A. 2Dean, Rollins School of Public Health, Emory University, Atlanta, Georgia, U.S.A.
Quantitative Analysis of Plasmonic Metal Oxide Nanocrystal Ensembles Reveals the Influence of Dopant Selection on Intrinsic Optoelectronic Properties (2021)

LSPR arising from free charge carriers in doped metal oxide (MO) nanocrystals (NCs) has been explored abundantly already but there is still much to learn about the effect of dopant identity on the electronic structure of the host and, surface depletion layers. Here, using In2O3 as the host lattice, we discuss the contribution of a dopant to the electronic structure and rationalize an empirical understanding of how a particular dopant can impact surface depletion, carrier concentration, and carrier damping in doped MO NCs. To do this, we leverage a slow injection synthesis to incorporate four different dopants (Sn, Zr, Ti, and Ce) in In2O3 NCs of different radius. By fitting their plasmonic response, we extracted intrinsic electronic properties of the NCs such as surface depletion layer thickness, carrier concentration, and carrier damping, and rationalized the influence of dopant selection on each parameter.
Blastic natural killer-cell lymphoma of the skin associated with myelodysplastic syndrome or myelogenous leukaemia: a coincidence or more? (2003)

We report three patients with blastic natural killer (NK)-cell lymphoma of the skin associated with myelodysplastic syndrome (MDS) (two patients) or subacute myelomonocytic leukaemia (one patient). In two patients MDS was diagnosed before skin lesions; the patient with leukaemia initially presented with skin lesions. Our patients had several clinical features in common, namely multiple skin lesions with a bruise-like appearance, involvement of the oral mucosa, and good general status at presentation but very rapid deterioration in the course of the disease. All patients died of disease 4-14 months after the diagnosis. Histopathologically, there were cutaneous infiltrates of slightly pleomorphic medium-sized cells expressing CD4, CD56, terminal deoxynucleotidyl transferase (focally) and being negative for surface CD3, cytotoxic molecules, B-cell-associated markers and myelomonocytic markers. Erythrocyte extravasation was seen in all patients. T-cell receptor genes were in germline configuration. MDS was classified as refractory cytopenia with multilineage dysplasia and ring sideroblasts and refractory anaemia with transition to refractory anaemia with excess of blasts. We reviewed similar cases reported in the literature showing coexistence of blastic NK-cell lymphoma/leukaemia and MDS or myelogenous leukaemia. We conclude that given an overall limited number of reported cases of blastic NK-cell lymphoma/leukaemia, its association with various myelodysplastic/myeloproliferative disorders seen in a subset of patients ( approximately 15-20%) is more than coincidental and may indicate their common origin.
Angular distribution control of extreme ultraviolet radiation from laser-produced plasma by manipulating the nanostructure of low-density SnO2 targets (2006)

We have found that the divergence of a relatively monochromatic extreme ultraviolet (EUV) emission from a laser-produced plasma can be manipulated by changing the target morphology which is a porous low-density tin oxide (SnO2) structure. The fundamental light of a Nd-YAG laser was irradiated on the target with laser intensity of ∼1011W∕cm2 and pulse duration of 10ns. The nanostructure and density of the targets were tuned by a combination of colloidal polymer template and sol-gel processes [Gu, Nagai, Norimatsu, Fujioka, Nishimura, Nishihara, Miyanaga, and Izawa, Chem. Mater. 17, 1115 (2005)], which has a merit in large-scale preparation. When the target has an open cell nanostructure, the EUV emission directed predominantly along target normal, while a closed cell target exhibited divergent emission. The angular distribution may be affected by the orientation of the microstructured initial target, and this phenomenon can be applied to wavefront control of EUV emission.
Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis (2018)

Abstract Background The majority of estrogen receptor-positive (ERα+) breast cancers respond to endocrine therapies. However, resistance to endocrine therapies is common in 30% of cases, which may be due to altered ERα signaling and/or enhanced plasticity of cancer cells leading to breast cancer subtype conversion. The mechanisms leading to enhanced plasticity of ERα-positive cancer cells are unknown. Methods We used short hairpin (sh)RNA and/or the CRISPR/Cas9 system to knockdown the expression of the dependence receptor UNC5A in ERα+ MCF7 and T-47D cell lines. RNA-seq, quantitative reverse transcription polymerase chain reaction, chromatin immunoprecipitation, and Western blotting were used to measure the effect of UNC5A knockdown on basal and estradiol (E2)-regulated gene expression. Mammosphere assay, flow cytometry, and immunofluorescence were used to determine the role of UNC5A in restricting plasticity. Xenograft models were used to measure the effect of UNC5A knockdown on tumor growth and metastasis. Tissue microarray and immunohistochemistry were utilized to determine the prognostic value of UNC5A in breast cancer. Log-rank test, one-way, and two-way analysis of variance (ANOVA) were used for statistical analyses. Results Knockdown of the E2-inducible UNC5A resulted in altered basal gene expression affecting plasma membrane integrity and ERα signaling, as evident from ligand-independent activity of ERα, altered turnover of phosphorylated ERα, unique E2-dependent expression of genes effecting histone demethylase activity, enhanced upregulation of E2-inducible genes such as BCL2, and E2-independent tumorigenesis accompanied by multiorgan metastases. UNC5A depletion led to the appearance of a luminal/basal hybrid phenotype supported by elevated expression of basal/stem cell-enriched ∆Np63, CD44, CD49f, epidermal growth factor receptor (EGFR), and the lymphatic vessel permeability factor NTN4, but lower expression of luminal/alveolar differentiation-associated ELF5 while maintaining functional ERα. In addition, UNC5A-depleted cells acquired bipotent luminal progenitor characteristics based on KRT14+/KRT19+ and CD49f+/EpCAM+ phenotype. Consistent with in vitro results, UNC5A expression negatively correlated with EGFR expression in breast tumors, and lower expression of UNC5A, particularly in ERα+/PR+/HER2− tumors, was associated with poor outcome. Conclusion These studies reveal an unexpected role of the axon guidance receptor UNC5A in fine-tuning ERα and EGFR signaling and the luminal progenitor status of hormone-sensitive breast cancers. Furthermore, UNC5A knockdown cells provide an ideal model system to investigate metastasis of ERα+ breast cancers.
A low-power CMOS mixer for low-IF receivers (2003)

A low-power UHF-to-low-IF downconversion mixer was implemented in a 0.5-/spl mu/m CMOS process. This mixer is designed as the second-block of an integrated low-IF receiver under development for deep space applications. The mixer dissipates 5.4 mW from a 2.5-V supply. LO power requirement is -10 dBm. Voltage conversion gain is 20.8 dB. Single side-band noise figure is 9.2 dB at 2 MHz IF. Input 1-dB compression point is -21 dBm while the IIP3 point is at -13.4 dBm. The entire mixer occupies a die area of 0.3 mm /spl times/ 0.26 mm. Low-power dissipation makes this mixer attractive for low-power highly integrated receiver applications.
Characterization of long-range surface plasmon Bragg gratings with microfluidic channels (2015)

A long-range surface plasmon polariton Bragg grating composed of gold stripes in CYTOP, with an etched microfluidic channel is presented in this work. PBS/Gly is used as the buffer solution with a refractive index close to CYTOP. The output power of the device is measured over wavelength and the results are discussed.
Light aversion in mice depends on nonimage-forming irradiance detection. (2010)

Detection of light in the eye underlies image-forming vision, but also regulates adaptive responses in physiology and behavior. Typically these adaptive responses do not involve image-forming vision, but depend on a relatively absolute measure of brightness (nonimage-forming irradiance detection). The goal of this study was to further understand how image-forming vision and nonimage-forming irradiance detection contribute to the effects of light on behavior. Three light dependent behaviors were assessed in wild-type, Rpe65-/- and rd1 mice. In Rpe65-/- mice, nonimage-forming irradiance detection is severely attenuated, but rod based visual acuity is relatively preserved. In rd1 mice visual acuity is nonrecordable, but nonimage-forming responses are less severely attenuated than Rpe65-/-. Positive masking, an image-forming vision dependent increase in wheel running, was absent in rd1 and restricted to higher irradiances in Rpe65-/-. Negative masking, a suppression of wheel running sensitivity with nonimage-forming irradiance detection input, was increased in rd1, but reduced in Rpe65-/- mice. By contrast, light aversion, an avoidance of brightly lit areas, was abolished in both Rpe65-/- and rd1. This shows that image-forming vision is not sufficient for light aversion, suggesting nonimage-forming irradiance detection motivates this behavior. Further, the differing effects of disease suggest that negative masking and light aversion are distinct responses with specialized nonimage-forming irradiance detection pathways.