gebhart/patrepeval huggingface dataset:
Langmuir-Blodgett Films of Amphiphilic Push-Pull Porphyrins (1994)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLangmuir-Blodgett Films of Amphiphilic Push-Pull PorphyrinsHomer Chou, Chin-Ti Chen, Kurt F. Stork, Paul W. Bohn, and Kenneth S. SuslickCite this: J. Phys. Chem. 1994, 98, 2, 383–385Publication Date (Print):January 1, 1994Publication History Published online1 May 2002Published inissue 1 January 1994https://pubs.acs.org/doi/10.1021/j100053a003https://doi.org/10.1021/j100053a003research-articleACS PublicationsRequest reuse permissionsArticle Views377Altmetric-Citations100LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Compositional dependence of pyrobitumen formation in petroleum reservoirs (2004)

Pyrobitumen is solid, insoluble bitumen originating from the thermal degradation of liquid oil. Prospecting for petroleum in deep, hot reservoirs increases the risk that the reservoir will contain pyrobitumen which acts as a porosity and permeability-reducing cement and is thus considered highly detrimental to reservoir quality. Due to its relatively low density, it also leads to incorrect wireline log estimates of the oil in place. The aim of this work was to determine the pyrobitumen formation potential of immature, heavy type II oil and its constituents as a result of thermal cracking. Closed system gold tube pyrolysis was used to artificially mature asphaltic oil (Boscan, Venezuela) at temperatures from 300-550°C for 4 hours. Samples of the same oil were fractionated into saturate, aromatic, resin, and asphaltene (SARA) components which were pyrolysed isothermally under the same conditions as for the whole oil. At 500°C all fractions produced pyrobitumen although asphaltenes yield more insoluble residue (62%wt) compared to the saturates (19%wt). In addition the asphaltene and resin fractions produced pyrobitumen at lower temperature than the aromatics and saturates. Petrographic analysis of the insoluble residues indicates that reflectance evolution and graphitizing potential vary according to the composition of the oil precursor. This work shows that whilst pyrobitumen is a natural consequence of thermal cracking disproportionation, the amount of pyrobitumen produced and its physico-chemical and optical properties are strongly dependent on precursor oil composition.
Probing the sources of ambient seismic noise near the coasts of southern Italy (2007)

In this study we probe the source of ambient noise in the southern Apennines and the Calabrian Arc by cross‐correlating two months of ambient seismic noise records collected during the Calabria‐Apennine‐Tyrrhenian/Subduction‐Collision‐Acretion Network (CAT/SCAN) project. Significant Rayleigh wave energy is observed on the vertical component of the noise correlation stacks and reveals multiple sources of ambient noise in southern Italy. The most dominant noise sources are found along (1) the Tyrrhenian coast of northern Calabria‐southern Campania and (2) the Adriatic Sea near the Gargano Promontory. Enhanced ocean currents evident from buoy records during the study period could be responsible for the observed microseisms. We validate the source locations using earthquake records and the consistency between noise and earthquake correlation functions supports the observed dominant directions of ambient seismic noise.
Sex- and age-dependent genetics of longevity in a heterogeneous mouse population (2022)

DNA variants that modulate life span provide insight into determinants of health, disease, and aging. Through analyses in the UM-HET3 mice of the Interventions Testing Program (ITP), we detected a sex-independent quantitative trait locus (QTL) on chromosome 12 and identified sex-specific QTLs, some of which we detected only in older mice. Similar relations between life history and longevity were uncovered in mice and humans, underscoring the importance of early access to nutrients and early growth. We identified common age- and sex-specific genetic effects on gene expression that we integrated with model organism and human data to create a hypothesis-building interactive resource of prioritized longevity and body weight genes. Finally, we validated <i>Hipk1</i>, <i>Ddost</i>, <i>Hspg2</i>, <i>Fgd6</i>, and <i>Pdk1</i> as conserved longevity genes using <i>Caenorhabditis elegans</i> life-span experiments.
Effects of gait training using a robotic constraint (LokomatÂ®) on gait kinematics and kinetics in chronic stroke patients (2014)

This type of training may be effective to improve gait in hemiparetic patients. A larger investigation of the training programme is justified.
La fin d'Alzheimer : le premier programme qui prévient et inverse le déclin cognitif : le protocole ReCODE (2018)

Presentation du protocole therapeutique ReCODE qui permet d'identifier, pour chaque individu, les facteurs aggravant la maladie d'Alzheimer : l'alimentation, l'activite physique, le stress, les carences en nutriments et les deficits hormonaux. L'auteur, qui a elabore avec son equipe ce programme, donne egalement les cles pour consolider les ameliorations obtenues. ©Electre 2018
The Binding Thermodynamics of Drug Candidates (2015)

The affinity optimization of drug candidates is a major goal in drug development. Affinity optimization is not a simple task because it needs to adhere to constraints that maintain or improve the drug-like character of the compound. The binding affinity is dictated by the Gibbs energy of binding. Drug molecules are composed of polar and nonpolar (carbon) atoms and they contribute very differently to the enthalpy change. In binding, two processes occur simultaneously: desolvation and the formation of drug/protein interactions. Two terms are of major concern from an engineering point of view: the solvation/desolvation entropy and the conformational entropy. The desolvation of both polar and nonpolar groups is favorable to binding. The Lipophilic Efficiency (LipE) is essentially a measurement of the binding affinity minus the hydrophobicity of a compound. Measuring the binding enthalpy provides an immediate account of the enthalpic efficacy of the polar functionalities.
Titelbild: Die Entdeckung und Synthese von marinen Polyethern (Angew. Chem. 38/2008) (2008)

Eine Odyssee erzählen K. C. Nicolaou et al. in ihrem Aufsatz auf S. 7292 ff. nach: Von der Isolierung von Brevetoxin B, dem ersten marinen Biotoxin mit Leiterstruktur, im Jahr 1981 bis hin zur Synthese von Maitotoxin-Moleküldomänen. Im Kreis ist der Dinoflagellat Gambierdiscus toxicus (Bild: Steve L. Morton, NOAA) abgebildet, der Maitotoxin, den größten und giftigsten bekannten Nichtprotein-Sekundärmetabolit, produziert. Über Doktorfische (Bild: moodboard/Corbis) kann das Nervengift vom Menschen aufgenommen werden und die Ciguatera-Fischvergiftung verursachen.
Studying the Structural Significance of Galectin Design by Playing a Modular Puzzle: Homodimer Generation from Human Tandem-Repeat-Type (Heterodimeric) Galectin-8 by Domain Shuffling (2017)

Tissue lectins are emerging (patho)physiological effectors with broad significance. The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is based on molecular selection of matching partners. Engineering of variants by changing the topological display of carbohydrate recognition domains (CRDs) provides tools to understand the inherent specificity of the functional pairing. We here illustrate its practical implementation in the case of human tandem-repeat-type galectin-8 (Gal-8). It is termed Gal-8 (NC) due to presence of two different CRDs at the N- and C-terminal positions. Gal-8N exhibits exceptionally high affinity for 3'-sialylated/sulfated β-galactosides. This protein is turned into a new homodimer, i.e., Gal-8 (NN), by engineering. The product maintained activity for lactose-inhibitable binding of glycans and glycoproteins. Preferential association with 3'-sialylated/sulfated (and 6-sulfated) β-galactosides was seen by glycan-array analysis when compared to the wild-type protein, which also strongly bound to ABH-type epitopes. Agglutination of erythrocytes documented functional bivalency. This result substantiates the potential for comparative functional studies between the variant and natural Gal-8 (NC)/Gal-8N.
Oxidative Dehydrogenation of Ethane to Ethylene over V<sub>2</sub>O<sub>5</sub>/Al<sub>2</sub>O<sub>3</sub> Catalysts: Effect of Source of Alumina on the Catalytic Performance (2014)

A series of V2O5/Al2O3 catalysts with fixed V2O5 content (10 wt %) but varying Al2O3 supports were prepared by impregnation technique and tested for the oxidative dehydrogenation of ethane (ODHE) to ethylene in a fixed bed quartz reactor in the temperature range from 500 to 600 °C. The nature of alumina support applied had a significant influence on the catalytic performance. Among all alumina supports investigated, the high surface area γ-Al2O3 (200–300 m2/g) supported V2O5 catalyst showed the best performance in ODHE with selectivity to ethylene of ca. 45–50%. This result is mainly due to the high dispersion of vanadia species on the support surface. On the other hand, low surface area α-Al2O3 (5 m2/g) and γ-Al2O3 (<100 m2/g) supported catalysts exhibited much higher ethane conversion under the same reaction conditions, but they also exhibited low selectivity to ethylene because of the existence of larger V2O5 crystallites. In addition, a structurally disordered γ-Al2O3 (ca. 6 m2/g) containing a high proportion of penta-coordinated Al-sites was also included in the present study. Amazingly, this low surface area alumina supported V2O5 catalyst displayed a good performance in ODHE. Such behavior can be ascribed mainly to the presence of the penta-coordinated Al surface sites acting as anchors for preferentially monomeric and oligomeric VOx species leading to a prime dispersion. Therefore, performance similar to that of the high surface area aluminas was reached.
Supplementary Table S6 from Radiotherapy Induces Innate Immune Responses in Patients Treated for Prostate Cancers (2023)

&lt;p&gt;Linear Mixed Effect Models analysis of proteomics data combining all time points post-RT.&lt;/p&gt;
SANALDA: A Source Authenticating Network Architecture Limiting DoS Attacks (2006)

We present a novel and incrementally deployable network architecture, aiming at preventing IP spoofing and DoS attacks. Our design prevents forged IP packets from entering the network and accessing the destination service, while assuring simple and fast access to compliant users. Our system enforces user authentication on the IP level, periodically stamping each IP packet with a unique, identity-based signature of the sender. Spoofed packets are detected as soon as they arrive at the source authenticating router, by detecting discrepancies between signatures in the packet headers and their declared IP address or by checking special markings. In addition, we use capabilities to enable the receivers to decide which senders are allowed to send traffic. Hence, our architecture limits the impact of DoS attacks, which use either spoofed or non-spoofed IP traffic. To the best of our knowledge, no prior work has used Identity Based Signatures for IP host authen-tication. We propose an IBS-based solution that addresses a broad range of network vulnerabilities. We implemented our design as a router module to measure the associated performance degradation and demonstrate its potential for Internet-wide deployment.
Supplementary Figure 4 from Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance (2023)

Supplementary Figure 4 from Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance
An indirect time-of-flight measurement technique for sub-mm range resolution using impulse photocurrent response (2014)

This paper presents a new ToF measurement technique using an impulse photocurrent response. In the proposed technique, a laser with a short pulse width for light source, which can be regarded as an impulse input for a detector. As a result, the range calculation is determined only by photocurrent response of the detector. A test chip fabricated in a 0.11um CIS technology employs a draining-only modulation pixel, which enables a high speed charge modulation. The measurable range measured to be 50 mm within nonlinear error of 5% and the average range resolution of 0.21 mm is achieved.
Supplementary Table 2 from Kaposi Sarcoma Herpesvirus Promotes Endothelial-to-Mesenchymal Transition through Notch-Dependent Signaling (2023)

&lt;p&gt;PDF file - 119K&lt;/p&gt;
Labdane‐type diterpenoids from <i>Leonurus heterophyllus</i> and their cholinesterase inhibitory activity (2010)

In the course of screening plants used in natural medicines as memory enhancers, a 70% ethanol extract of the aerial parts of Leonurus heterophyllus showed significant AChE inhibitory activity. Bioassay-guided fractionation and repeated column chromatography led to the isolation of a new labdane-type diterpenoids (1), named leoheteronin F, and six known compounds (2-7). The chemical structures of isolated compounds were elucidated based on extensive 1D and 2D NMR spectroscopic data. The isolates 1-7 were investigated in vitro for their anticholinesterase activity using mouse cortex AChE enzyme. Leoheteronin A (5) and leopersin G (7), which possess a 15,16-epoxy group at the side chain, were found to be potent in the inhibition of AChE.
Molecular Simulations of Zeolites: Adsorption, Diffusion, and Shape Selectivity (2008)

ADVERTISEMENT RETURN TO ISSUEPREVReviewNEXTMolecular Simulations of Zeolites: Adsorption, Diffusion, and Shape SelectivityBerend Smit*, , and Theo L. M. MaesenView Author Information Department of Chemical Engineering, University of California, Berkeley, California 94720-1462, Van't Hoff Institute for Molecular Sciences, University of Amsterdam, Nieuwe Achtergracht 166, 1018 WV Amsterdam, The Netherlands, and Centre Européen de Calcul Atomique et Moléculaire (CECAM), Ecole Normale Supérieure, 46 Allée d'Italie, 69007 Lyon France Chevron, Energy Technology Company, 100 Chevron Way, Richmond, California 94802-0627*To whom correspondence should be addressed: Department of Chemical Engineering, University of California, Berkeley, 101B Gilman Hall #1462, Berkeley, CA 94720-1462.Cite this: Chem. Rev. 2008, 108, 10, 4125–4184Publication Date (Web):September 25, 2008Publication History Received8 August 2002Published online25 September 2008Published inissue 8 October 2008https://pubs.acs.org/doi/10.1021/cr8002642https://doi.org/10.1021/cr8002642review-articleACS PublicationsCopyright © 2008 American Chemical SocietyRequest reuse permissionsArticle Views15549Altmetric-Citations652LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Diffusion,Free energy,Molecules,Transport properties,Zeolites Get e-Alerts
Genetics and genetic testing of dilated cardiomyopathy: a new perspective. (2013)

The completion of the Human Genome Project was a landmark achievement, but as clinical genetic testing becomes more mainstream, the extent of remarkable genetic variation is increasingly being appreciated. Newer DNA sequencing technology can now complete the sequencing of an entire human genome several times over in a matter of days, but this will undoubtedly add new challenges to the difficulty of distinguishing true pathogenic variants from benign variants in diagnostic genetics and in the research setting. The recent discovery of the role of titin gene (TTN) mutations in dilated cardiomyopathy (DCM) will make genetic testing in this disease more efficient. Furthermore, better understanding of genotype-phenotype associations will assist clinicians in identifying early stages of disease and providing more appropriate treatments. This high level of complexity requires an expert genetic team to offer counseling and to manage, deliver, and follow-up over time the results of genetic testing, which is particularly important for screening of family members potentially at risk. In DCM, genetic testing may be useful for the identification of non-carriers and asymptomatic carriers, as well as for prevention strategies, sport recommendations, and defibrillator implantation. It can also guide reproductive decision-making including utilization of pre-implantation genetic diagnostic strategies.
Micro-Fabrication of Ferromagnetic Tunnel Junctions Using Ar Ion Milling. (1999)

The effect of the Ar ion milling process on tunnel magneto-resistance was investigated by using Ar ion milling to make a small hole at the center of the active area of a junction prepared by means of metal masks. Metallic short-circuiting through the material redeposited during Ar ion milling was evaluated by comparing the tunnel resistance before and after the process. The amount of redeposited material was small in the samples produced by the milling process with a higher incident angle of Ar ions. Small Ni-Fe/Co/Al-O/Co junctions with various active area ranged from 9 to 104 μm2 were also fabricated. The tunnel resistance increased in inverse proportion to the active area. Many junctions showed a TMR ratio of 9%-13%, which was as large as the value for junctions prepared by means of metal masks.
Phytochemical analysis and evaluation of the cytotoxic, antimicrobial and antioxidant activities of essential oils from three Plectranthus species grown in Saudi Arabia (2018)

The observed results back the suggestion that these three Plectranthus species represent a promising source of cytotoxic and antimicrobial agents.
Identification of early alterations during hepatic oncogenesis in c-Myc/Tgfα transgenic mice by transcriptome analysis (2007)

3848 Hepatocellular carcinoma (HCC) is one of the most common cancers in the world, accounting for an estimated 600,000 deaths annually. Although much is known about both the etiological agents and the cellular changes that lead to HCC, the molecular pathogenesis of HCC is not well understood, partly due to the difficulty of analyzing the early stages of the disease. In this context, genetically engineered mice that recapitulate human HCC are valuable experimental models for a sequential analysis of tumor development. We previously reported that the gene expression profiles of HCCs derived from c-Myc/Tgfα transgenic mice closely reproduce those observed in a subset of human HCC with a poor prognosis (Nat. Genet., 36:1306-11, 2004). Here, we report a detailed characterization of HCC development in c-Myc/Tgfα mice starting from the early to late stages based on gene expression profiles. The tumor development in c-Myc/Tgfα mice was associated with progressive and cumulative transcriptional alterations. Already in 3 week old mice, microarray analysis revealed an induction of genes involved in replication (e.g. Mcm6, Mcm7, Myc), DNA repair (e.g. Ddb2, Rad51l1) and translation (e.g. Eef1b2, Eef2, Rpl13) characteristic of an active hepatocyte proliferation. Livers of 3 month old mice showed more extensive dysplastic changes, frequent mitosis, as well as the first signs of genomic instability along with an elevated production of reactive oxygen species. These cellular alterations coincided with an oxidative stress gene expression signature with the up-regulation of genes involved in DNA repair (e.g. Ddb2, Mlh1, Msh3, Rad51ap1), fatty acid beta-oxidation (e.g. Acaa1b, Acadm), and detoxication (e.g. Gsta1, Ugt1a9). At eight months, 100% of mice developed HCC in a background of wide-spread hepatic dysplasia. The gene expression profiles in the livers of 3 month old mice were highly similar to those of surrounding non-tumorous livers of 8 month old mice. However, the most noticeable difference was the simultaneous induction of ligands for natural killer cells (e.g. Raet1a-e) and the repression of MHC-I, specifically at 3 months. Flow cytometry experiments on purified hepatocytes confirmed these results that could be interpreted as an early mechanism of immunosurveillance to prevent the emergence and clonal expansion of progenitors for liver tumors. We conclude that tumor development in c-Myc/Tgfα mice results from a progressive accumulation of genetic alterations due to both a general metabolic disorder generating a chronic oxidative stress environment and an active hepatocyte proliferation. Moreover, our study strongly suggests that a disruption of the innate immune surveillance may contribute to a rapid selection of tumor clones at the early stages of hepatocarcinogenesis.
Therapie von Krebszellen mit einem über E2F gesteuerten, replikationsselektiven Adenovirus (2004)

Einleitung: E2F Transkriptions-Faktoren sind als kritische Zellwachstums-Regulatoren in malignen Zellen als Folge des dort häufig alterierten pRb/E2F/p16-Zyklus oft überexprimiert. Dies führt zu dazu, dass die meisten Tumorzellen stark proliferieren. Wir testeten die Hypothese, dass ein über einen E2F Promotor gesteuerter Adenovirus (Ad) sich selektiv in Tumorzellen repliziert und somit zur direkten Onkolyse seiner Wirtszellen führt.
Low-Rank Spatial Channel Estimation for Millimeter Wave Cellular Systems (2017)

The tremendous bandwidth available in the millimeter wave frequencies above 10 GHz have made these bands an attractive candidate for next-generation cellular systems. However, reliable communication at these frequencies depends critically on beamforming with very high-dimensional antenna arrays. Estimating the channel sufficiently accurately to perform beamforming can be challenging due to both low coherence time and a large number of antennas. Also, the measurements used for channel estimation may need to be made with analog beamforming, where the receiver can “look” in only one direction at a time. This paper presents a novel method for estimation of the receive-side spatial covariance matrix of a channel from a sequence of power measurements made in different angular directions. It is shown that maximum likelihood estimation of the covariance matrix reduces to a non-negative matrix completion problem. We show that the non-negative nature of the covariance matrix reduces the number of measurements required when the matrix is low-rank. The fast iterative methods are presented to solve the problem. Simulations are presented for both single-path and multi-path channels using models derived from real measurements in New York City at 28 GHz.