gebhart/patrepeval huggingface dataset:
Line Drawing Interpretation in a Multi-View Context (2015)

HAL is a multi-disciplinary open access archive for the deposit and dissemination of sci-entific research documents, whether they are pub-lished or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L’archive ouverte pluridisciplinaire HAL, est destinée au dépôt et a ̀ la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d’enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.
The use of User Experience Questionnaire Plus (UEQ+) for cross-cultural UX research: evaluating Zoom and Learn Quran Tajwid as online learning tools (2022)

This paper aims to adapt and validate the User Experience Questionnaire Plus (UEQ+) in the Indonesian context. The UEQ+ is a modular extension of the User Experience Questionnaire (UEQ), which has been adapted to the Indonesian context and used in many studies. The UEQ+ was originally developed in German and English. As a modular extension, the UEQ+ has more user experience (UX) scales compared to the UEQ and can be used to evaluate products in special scenarios. Several steps were carried out to adapt and validate the UEQ+: translating the questionnaire into Bahasa by involving UX practitioners, evaluating the translation results by involving a UX expert and practitioners, and conducting face validity and reliability testing through two case studies (Zoom and Learn Quran Tajwid as online learning tools). The results showed that the findings from the open-ended questionnaire were consistent with the results of the six scales. Future work is needed to investigate whether the UEQ+ can capture some of the UX-related themes identified from the two case studies.
Improving neural decoding in the central auditory system using bio-inspired spectro-temporal representations and a generalized bilinear model (2015)

We study the impact of different encoding models and spectro-temporal representations on the accuracy of Bayesian decoding of neural activity recorded from the central auditory system. Two encoding models, a generalized linear model (GLM) and a generalized bilinear model (GBM), are compared along with three different spectro-temporal representations of the input stimuli: a spectrogram and two bio-inspired representations, i.e. a gammatone filter bank (GFB) and a spikegram. Signal to noise ratios between the reconstructed and original representations are used to evaluate the decoding, or reconstruction accuracy. We experimentally show that the reconstruction accuracy is best with the spikegram representation and worst with the spectrogram representation and, furthermore, that using a GBM instead of a GLM significantly increases the reconstruction accuracy. In fact, our results show that the spikegram reconstruction accuracy with a GBM fitting yields an SNR that is 3.3 dB better than when using the standard decoding approach of reconstructing a spectrogram with GLM fitting.
PRANE: ouvrages de PRotection soumis à l'Action de la NEige (2004)

ABSTRACT In mountainous regions, snow can generate major hazards for civil structures. PRANE project sponsored by French Civil-engineering and Research Ministries gathers several laboratories in the field of structures subjected to snow effects. Two main domains are studied: the first one concerns rigid passive protection structures directly subjected to snow avalanches in run-out zones. The second one deals with flexible snow-supporting structures used as active protection systems in avalanche starting zones. This paper recalls the main objectives of the PRANE project and gives as example, elements about the analysis of the destruction of two deflective walls in Taconnaz during winter 1999.
Supplementary Figure 1 from Sequential Binary Gene Ratio Tests Define a Novel Molecular Diagnostic Strategy for Malignant Pleural Mesothelioma (2023)

&lt;p&gt;PDF file - 188K, Heat-map of the 26-gene signature used in the sequential combination of gene expression ratio tests in the 112 thoracic samples. Probes are annotated with gene symbol on the right. Relative gene expression levels are given by the scale at the top. The red asterisk indicates the mesothelioma samples.&lt;/p&gt;
Time-resolved spectroscopy of laser-induced breakdown in water (1996)

Laser pulses of 60-ps and 80-ps at a wavelength of 532-nm and 1064-nm respectively were used to produce laser induced breakdown in triple-distilled water. The resulting luminescent flash from the plasma was captured with an imaging spectrograph coupled to a streak camera with a 5-ps time resolution. The wavelength range was 350 to 900-nm. We present the resulting experimental data which gives plasma duration and time-resolved spectral information. Plasma temperature is also computed from the data. All parameters are presented at a pulse energy of 1-mJ and are compared with time-integrated spectra at the same pulse duration and at 5 to 7-ns pulse duration in a similar energy range.
Chemoembolization of the Left Inferior Phrenic Artery in Patients With Hepatocellular Carcinoma: 9-Year Single-Center Experience (2010)

Selective chemoembolization via the left inferior phrenic artery is possible and results in good response of tumors supplied exclusively by the left inferior phrenic artery.
Three-Dimensional Non-Volatile Magnetic Universal Logic Gates (2011)

We present an experimental study on ultra-dense 3-D non-volatile magnetic universal logic gates with reconfigurable AND and OR functions. A four-layer magnetic structure with a net thickness of less than 30 nm is employed as a study illustration of a highly scalable magnetic logic device. In the device, the magnetic state of the top output soft layer depends on the magnetic states of the remaining three hard layers used as two input and one reset layers, respectively. To build vertically oriented magnetic devices with a gradient of the coercivity and the magnetization across the thickness, we use Co/Pd multilayers sputter-deposited via a combinatorial synthesis. Through a focused magneto-optical Kerr effect (F-MOKE) study, we relate input and output states in the 4-layer logic device to shoulders on major and minor M-H hysteresis loops. We use magnetic force microscopy (MFM) to identify magnetic logic operations.
Heme and menaquinone induced electron transport in lactic acid bacteria (2009)

We propose that the cyd-genes were present in the common ancestor of lactic acid bacteria, and that multiple gene-loss events best explains the observed distribution of these genes among the species.
The C-matrix: augmentation and reduction in the analysis of chemical composition and structure (2013)

Abstract We propose a unified linear-algebraic approach that allows determining the three key matrices of chemical kinetics: molecular, stoichiometric and Horiuti matrix, all within a single procedure. This procedure is based on calculating a so called C-matrix, which is obtained from each matrix by augmenting it with a unit matrix and then reducing to Reduced Row Echelon Form (RREF). The procedure is rigorous and efficient to find answers to typical questions of chemical engineering and chemical kinetics, i.e., finding the independent components and reactions, expressing in them the dependent ones, and determining independent routes of complex chemical reactions as well. Contrary to the previous analysis procedures, the C-matrix contains all bookkeeping information on dependencies of components and elements, and their balances. The procedure can be used for developing new software tools in the analysis of complex chemical composition and networks.
&lt;i&gt;Hevea brasiliensis&lt;/i&gt; Latex Allergens: Current Panel and Clinical Relevance (2004)

Latex allergy has been studied in detail in Europe and the US over the past two decades, resulting in specific guidelines that succeeded in reducing its incidence in high-risk populations within the medical field. How these developments have affected high-risk populations outside the health care scenario is an important unanswered question. In addition, a second wave of latex allergy may occur in nations that are striving to attain higher economic and technologic standards, including population-dense countries such as China. Therefore, the application of Hevea allergens in novel diagnostic assays and the development of specific latex immunotherapy will provide new opportunities for latex allergy research. In this review, we summarize current knowledge on the immunological properties of the 13 officially accepted Hevea brasiliensis latex allergens.
Regenerative Polysulfide-Scavenging Layers Enabling Lithium–Sulfur Batteries with High Energy Density and Prolonged Cycling Life (2017)

Lithium-sulfur batteries, notable for high theoretical energy density, environmental benignity, and low cost, hold great potential for next-generation energy storage. Polysulfides, the intermediates generated during cycling, may shuttle between electrodes, compromising the energy density and cycling life. We report herein a class of regenerative polysulfide-scavenging layers (RSL), which effectively immobilize and regenerate polysulfides, especially for electrodes with high sulfur loadings (e.g., 6 mg cm<sup>-2</sup>). The resulting cells exhibit high gravimetric energy density of 365 Wh kg<sup>-1</sup>, initial areal capacity of 7.94 mAh cm<sup>-2</sup>, low self-discharge rate of 2.45% after resting for 3 days, and dramatically prolonged cycling life. Such blocking effects have been thoroughly investigated and correlated with the work functions of the oxides as well as their bond energies with polysulfides. This work offers not only a class of RSL to mitigate shuttling effect but also a quantified design framework for advanced lithium-sulfur batteries.
Plasma etching of cavities into diamond anvils for experiments at high pressures and high temperatures (2011)

We describe a method for precisely etching small cavities into the culets of diamond anvils for the purpose of providing thermal insulation for samples in experiments at high pressures and high temperatures. The cavities were fabricated using highly directional oxygen plasma to reactively etch into the diamond surface. The lateral extent of the etch was precisely controlled to micron accuracy by etching the diamond through a lithographically fabricated tungsten mask. The performance of the etched cavities in high-temperature experiments in which the samples were either laser heated or electrically heated is discussed.
Synthesis of<i>N</i>‐[<sup>11</sup>C]Methyl‐4‐Piperidinyl Propionate ([<sup>11</sup>C]PMP) (2015)

Acetylcholinesterase (AChE) catalyzes the hydrolysis of the neurotransmitter acetylcholine to choline and acetic acid, leading to the termination of cholinergic neurotransmission. The activity of AChE is an important marker for degeneration of the central cholinergic system. 11C-labeled piperidinyl ester, 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP), serves as AChE substrate and is hydrolyzed to a hydrophilic product, N-[11C]methyl-4-piperidinol (MPOH), which does not cross the blood–brain barrier, and is irreversibly trapped locally in the brain according to the distribution of AChE enzyme activity. In the past, when [11C]PMP was synthesized, its free base precursor was prepared and dried prior to every synthesis. This chapter summarizes quality control procedures for [11C]PMP, based upon the current requirements for radiopharmaceuticals laid out in the US Pharmacopeia. Some of the procedures include visual Inspection, radiochemical identity, radiochemical purity, sterile filter integrity test, endotoxin analysis, and sterility testing.
Kinetics of uptake and degradation of an abrin immijnotoxin by melanoma cells and studies of the rates of cellular intoxication (1988)

The mechanism of action of an abrin 9.2.27 antimelanoma antibody conjugate has been studied in 2 human melanoma cell lines, FEMX and LOX, which differ in sensitivity to the immunotoxin (IT) and to native abrin. The IT, which had been affinity purified before use to remove molecules with exposed gal-binding sites on the toxin B-chain, inhibited cellular protein synthesis at a faster rate in the LOX than in the FEMX cells despite the fact that the LOX cells express less specific antigen and bind less IT to the cell surface. Surface-bound abrin-IT, as well as surface-bound specific antibody, disappeared at equal rates from the cell surface of the 2 cell lines. After binding of labelled IT the disappearance of total cell-associated radioactivity, as well as the appearance of TCA-precipitable and TCA-soluble radioactivity in the incubation medium, occurred at faster rates in the LOX than in the FEMX cells. No free abrin or antibody B-chain complex could be detected in the medium or inside the cells. The results indicate that the different sensitivities of the melanoma cell lines reflect different abilities to process endocytosed IT and to translocate the active A-chain to the cytosol. Experiments carried out in the presence of lactose are interpreted to mean that the A-chain may be translocated to the cytosol by two mechanisms, one involving antigen-antibody interaction and one involving the B-chain, and that the lectin binding site contributes to the B-chain-facilitated mechanism.
Tau seeds from patients induce progressive supranuclear palsy pathology and symptoms in primates (2022)

Progressive supranuclear palsy is a primary tauopathy affecting both neurons and glia and is responsible for both motor and cognitive symptoms. Recently, it has been suggested that progressive supranuclear palsy tauopathy may spread in the brain from cell to cell in a 'prion-like' manner. However, direct experimental evidence of this phenomenon, and its consequences on brain functions, is still lacking in primates. In this study, we first derived sarkosyl-insoluble tau fractions from post-mortem brains of patients with progressive supranuclear palsy. We also isolated the same fraction from age-matched control brains. Compared to control extracts, the in vitro characterization of progressive supranuclear palsy-tau fractions demonstrated a high seeding activity in P301S-tau expressing cells, displaying after incubation abnormally phosphorylated (AT8- and AT100-positivity), misfolded, filamentous (pentameric formyl thiophene acetic acid positive) and sarkosyl-insoluble tau. We bilaterally injected two male rhesus macaques in the supranigral area with this fraction of progressive supranuclear palsy-tau proteopathic seeds, and two other macaques with the control fraction. The quantitative analysis of kinematic features revealed that progressive supranuclear palsy-tau injected macaques exhibited symptoms suggestive of parkinsonism as early as 6 months after injection, remaining present until euthanasia at 18 months. An object retrieval task showed the progressive appearance of a significant dysexecutive syndrome in progressive supranuclear palsy-tau injected macaques compared to controls. We found AT8-positive staining and 4R-tau inclusions only in progressive supranuclear palsy-tau injected macaques. Characteristic pathological hallmarks of progressive supranuclear palsy, including globose and neurofibrillary tangles, tufted astrocytes and coiled bodies, were found close to the injection sites but also in connected brain regions that are known to be affected in progressive supranuclear palsy (striatum, pallidum, thalamus). Interestingly, while glial AT8-positive lesions were the most frequent near the injection site, we found mainly neuronal inclusions in the remote brain area, consistent with a neuronal transsynaptic spreading of the disease. Our results demonstrate that progressive supranuclear palsy patient-derived tau aggregates can induce motor and behavioural impairments in non-human primates related to the prion-like seeding and spreading of typical pathological progressive supranuclear palsy lesions. This pilot study paves the way for supporting progressive supranuclear palsy-tau injected macaque as a relevant animal model to accelerate drug development targeting this rare and fatal neurodegenerative disease.
Laminar and Temporal Heterogeneity of NMDA/Metabotropic Glutamate Receptor Binding in Posterior Cingulate Cortex (2000)

Both N-methyl-D-aspartate (NMDA) and quisqualate/AMPA-insensitive metabotropic glutamate (mGlu) receptors mediate plasticity induction in neocortex, but their interlaminar distribution in cortical microcircuits is largely unknown. We used (+)(3)H-MK801 and (3)H-glutamate binding plus saturating concentrations of NMDA, AMPA, and quisqualate to autoradiographically map NMDA and mGlu receptor sites by lamina in posterior cingulate cortex in adult male rats. Specific binding at NMDA receptor sites in laminae II/III and VI was significantly reduced in comparison to other laminae. Brains prepared from rats killed during dark phase of a 12h/12h light/dark cycle showed a mean 129% increase in overall (+)(3)H-MK801 binding versus light phase brains but retained reduced binding densities in laminae II/III and VI. In contrast to NMDA findings, specific binding at mGlu sites was consistently elevated during light phase in both laminae II/III and VI. Specific (3)H-glutamate binding in dark-phase brains showed an overall 147% increase versus light phase binding but did not retain significant interlaminar heterogeneity. Interpreted in accordance with our physiologically derived models of hippocampo-cortical microcircuitry, these results suggest that spatial and temporal variations in glutamate receptor distribution may play an important role in intracingulate neural processing of afferent input from hippocampus.
Applications of the human p53 knock‐in ( <i>Hupki</i> ) mouse model for human carcinogen testing (2010)

Tumor-driving mutations in the TP53 gene occur frequently in human cancers. These inactivating mutations arise predominantly from a single-point mutation in the DNA-binding domain of this tumor suppressor gene (i.e., exons 4-9). The human p53 knock-in (Hupki) mouse model was constructed using gene-targeting technology to create a mouse strain that harbors human wild-type TP53 DNA sequences in both copies of the mouse TP53 gene. Replacement of exons 4-9 of the endogenous mouse TP53 alleles in the Hupki mouse with the homologous normal human TP53 gene sequences has offered a humanized replica of the TP53 gene in a murine genetic environment. The Hupki mouse model system has proven to be an invaluable research tool for studying the underlying mechanisms of human TP53 mutagenesis. The utility of the Hupki mouse model system for exploring carcinogen-induced TP53 mutagenesis has been demonstrated in both in vivo animal experiments and in vitro cell culture experiments. Here, we highlight applications of the Hupki mouse model system for investigating mutagenesis induced by a variety of environmental carcinogens, including sunlight ultraviolet radiation, benzo[a]pyrene (a tobacco smoke-derived carcinogen), 3-nitrobenzanthrone (an urban air pollutant), aristolochic acid (a component of Chinese herbal medicine), and aflatoxin B1 (a food contaminant). We summarize the salient findings of the respective studies and discuss their relevance to human cancer etiology.
Theoretical Insights into the Selective Oxidation of Methane to Methanol in Copper-Exchanged Mordenite (2016)

Selective oxidation of methane to methanol is one of the most difficult chemical processes to perform. A potential group of catalysts to achieve CH4 partial oxidation are Cu-exchanged zeolites mimicking the active structure of the enzyme methane monooxygenase. However, the details of this conversion, including the structure of the active site, are still under debate. In this contribution, periodic density functional theory (DFT) methods were employed to explore the molecular features of the selective oxidation of methane to methanol catalyzed by Cu-exchanged mordenite (Cu-MOR). We focused on two types of previously suggested active species, CuOCu and CuOOCu. Our calculations indicate that the formation of CuOCu is more feasible than that of CuOOCu. In addition, a much lower C–H dissociation barrier is located on the former active site, indicating that C–H bond activation is easily achieved with CuOCu. We calculated the energy barriers of all elementary steps for the entire process, including catalyst activation, CH4 activation, and CH3OH desorption. Our calculations are in agreement with experimental observations and present the first theoretical study examining the entire process of selective oxidation of methane to methanol.
Relation entre le taux de rétention et la distribution de pores dans une membrane d'ultrafiltration (1981)

L'étude porte sur les propriétés d'ultrafiltration d'une membrane homogène anionique ; la distribution des rayons de pores a été déterminée par thermoporométrie. Les taux de rétention de solutés neutres et ioniques ont été déterminés et comparés à la fraction de pores accessibles y obtenue par thermoporométrie. En absence d'adsorption, on montre que le taux de rétention d'un soluté donné est égal à (1 — yR) avec yR la fraction de pores de rayon supérieur au rayon R de la molécule considérée ; un modèle de tamis rend alors bien compte du comportement de la membrane. En présence d'adsorption même faible (cas des dextranes dans l'eau), le taux de rétention du soluté déterminé à partir des flux de solvant et de soluté est supérieur à la valeur prévue à partir du volume hydrodynamique du soluté.
An Adaptive Mechatronic Exoskeleton for Force-Controlled Finger Rehabilitation (2021)

This paper presents a novel mechatronic exoskeleton architecture for finger rehabilitation. The system consists of an underactuated kinematic structure that enables the exoskeleton to act as an adaptive finger stimulator. The exoskeleton has sensors for motion detection and control. The proposed architecture offers three main advantages. First, the exoskeleton enables accurate quantification of subject-specific finger dynamics. The configuration of the exoskeleton can be fully reconstructed using measurements from three angular position sensors placed on the kinematic structure. In addition, the actuation force acting on the exoskeleton is recorded. Thus, the range of motion (ROM) and the force and torque trajectories of each finger joint can be determined. Second, the adaptive kinematic structure allows the patient to perform various functional tasks. The force control of the exoskeleton acts like a safeguard and limits the maximum possible joint torques during finger movement. Last, the system is compact, lightweight and does not require extensive peripherals. Due to its safety features, it is easy to use in the home. Applicability was tested in three healthy subjects.
Hydrothermal Duodenal Mucosal Resurfacing (2017)

The duodenum has become recognized as a metabolic signaling center that is involved in regulating insulin action and, therefore, insulin resistance states such as type 2 diabetes. Bariatric surgery and other manipulations of the upper intestine, in particular the duodenum, have shown that limiting nutrient exposure or contact in this key region exerts powerful metabolic effects. Early human clinical trial data suggest that endoscopic hydrothermal duodenal mucosal resurfacing is well tolerated in human subjects and has an acceptable safety profile. This article describes the rationale for this endoscopic approach and its early human use, including safety, tolerability, and early efficacy.
Design of a 600-Pixel-per-Inch, 30-Bit Color Scanner (1997)

Simply sampling an image at higher resolution will not give the results a customer expects. Other optical parameters such as image sharpness, signal-to-noise ratio, and dark voltage correction must improve to see the benefits of 600 pixels per inch.