gebhart/patrepeval huggingface dataset:
Highly Flexible Self-Expanding Meshed Metal Stents for Palliation of Malignant Esophagogastric Obstruction (1995)

Highly elastic self-expanding metal stents can be successfully implanted in the majority of patients, particularly in those with difficult malignant strictures not easily amenable to other methods. The devices provide good palliation with effective relief of dysphagia, easy handling and implantation, and offer a satisfactory quality of life to the patient. However, tumor ingrowth is a significant problem, even though it can be successfully managed by APC. Adequate covering of the stent that does not affect its mechanical properties or firm anchoring should solve at least some of these problems.
Unsaturation Elements and Other Modifications of Phospholipids in Bacteria: New Insight from Ultraviolet Photodissociation Mass Spectrometry (2020)

Glycerophospholipids (GPLs), one of the main components of bacterial cell membranes, exhibit high levels of structural complexity that are directly correlated with biophysical membrane properties such as permeability and fluidity. This structural complexity arises from the substantial variability in the individual GPL structural components such as the acyl chain length and headgroup type and is further amplified by the presence of modifications such as double bonds and cyclopropane rings. Here we use liquid chromatography coupled to high-resolution and high-mass-accuracy ultraviolet photodissociation mass spectrometry for the most in-depth study of bacterial GPL modifications to date. In doing so, we unravel a diverse array of unexplored GPL modifications, ranging from acyl chain hydroxyl groups to novel headgroup structures. Along with characterizing these modifications, we elucidate general trends in bacterial GPL unsaturation elements and thus aim to decipher some of the biochemical pathways of unsaturation incorporation in bacterial GPLs. Finally, we discover aminoacyl-PGs not only in Gram-positive bacteria but also in Gram-negative <i>C. jejuni</i>, advancing our knowledge of the methods of surface charge modulation that Gram-negative organisms may adopt for antibiotic resistance.
Automatic Evaluation of In-Car Communication Systems (2017)

Approximation of the Optimum Stepsize for Acoustic Feedback Cancellation Based on the Detection of Reverberant Signal Periods
Towards a Mono-Diameter Well – Advances in Expanding Tubing Technology (2000)

Abstract Solid steel tube can be readily expanded using forces, either mechanical or hydraulic available on most drilling and workover rigs. The process of drawing or pumping a mandrel through a length of tube can be used to expand the tube in situ. This process can be used to repair casing and tubing, shut off unwanted fluid entry into, and egress from the wellbore, repair sand screens, and act as a contingency liner in drilling applications. The ultimate use of expanded tubulars will be in the mono-diameter well, whereby the entire well is drilled and cased using effectively one hole size. The impact on drilling costs and performance will be dramatic. Expandable tubing technology has been applied in the three market segments of remediation, wellbore construction and sand control. A broad range of products is currently available for implementation in all three segments. A review of the principles of expandable tubing technology leads to a discussion of the likely evolution of the technology towards the monodiameter well. The implementation of expandable tubing will follow a pattern of replacement of conventional technologies, use through necessity, maintenance of diametric efficiency which will lead to the use of the technology within the basis of design of well construction. From this is but a small step to the monodiameter well. The principles of expandable tubing technology are well understood. The complexity arises from the system interactions between the materials, expansion process and the wellbore environment. These are explained and discussed.
Pitting damage imaging by non-linear ultrasonic technique: comparison between resonance and non-resonance modes (2013)

A non-linear ultrasonic method was applied for evaluating the cavitation damage, so-called pitting damage, in the mercury target of the Japan Spallation Neutron Source (JSNS). First, pitting damage was imposed on disk specimens in mercury using the magnetic impact testing machine (MIMTM) with various numbers of impacts (0, 104, 105, 106, 107 and 108). The pitting damage was imaged with resonance and non-resonance modes, respectively, by employing a non-linear acoustic imaging system. Waveform attenuation and generation of higher harmonics, which have high relevance to the degree of pitting damage, were useful for the imaging. Combined with the attenuation phenomenon, the resonance mode imaged the micropits with higher harmonics more effectively with higher harmonics, compared with the non-resonance mode.
Adjuvanted influenza vaccines (2013)

Influenza is one of the most common causes of human morbidity and mortality that is preventable by vaccination. Immunization with available vaccines provides incomplete protection against illness caused by influenza virus, especially in high-risk groups such as the elderly and young children. Thus, more efficacious vaccines are needed for the entire population, and all the more so for high-risk groups. One way to improve immune responses and protection is to formulate the vaccine with antigen carriers and/or adjuvants, which can play an important role in improving immune responses and delivery to antigen-presenting cells, especially for a vaccine like influenza that is based on protein antigens usually administered without a carrier or adjuvant. In this review, the authors present an overview of available vaccines, focusing on research and development of new adjuvants used in influenza vaccines, as well as adjuvanted influenza vaccines aimed to improve immune responses, protection and breadth of coverage for influenza.
Effect of fanning on the characteristics of double phase-conjugate mirror (1999)

The fanning influence on the characteristics of double phase- conjugate mirror was investigated. The time laws of basic, conjugated laser beams and fanning were obtained. It was shown that the generation of conjugated beam could exist under zero seed.
Transmission of <i>Xylella fastidiosa</i> subsp. pauca ST53 by the sharpshooter <i>Cicadella viridis</i> from different source plants and artificial diets (2022)

Abstract The sharpshooter Cicadella viridis L. (Hemiptera: Cicadellidae) is the most common sharpshooter in Europe and, given its xylem feeding behaviour, is considered a potential vector of the plant pathogenic bacterium Xylella fastidiosa Wells et al. (Xanthomonadales: Xanthomonadaceae ). We tested X. fastidiosa subsp. pauca ST53 ( Xfp ) transmission capabilities of C. viridis adults, namely i) acquisition efficiency from four host plant species – periwinkle, milkwort, lavender, alfalfa – and from two artificial diets (PD3 and Xfm), ii) inoculation efficiency to periwinkle at different times post acquisition from different plant and artificial diet sources. The main European vector species – Philaenus spumarius – was used as a control. Cicadella viridis was able to acquire Xfp from periwinkle, milkwort, and lavender, although with low efficiency (3–16%) and from artificial diets (23–25%). Successful inoculation on periwinkle was extremely rare, being observed only three times, following feeding on milkwort plant and PD3 artificial diet sources. Our study shows that C. viridis is not a relevant vector of Xfp , given the very low transmission rate in controlled conditions and the inability to feed on olive. The low efficiency reported here sums also to ecological constraints (mainly monocots host plants, humid environments) that make difficult to forecast a relevant role in dispersing X. fastidiosa , at least within the present distribution of the exotic bacterium in Europe. However, a possible role of this species in spreading Xf in other agroecosystems, e.g. vineyard and stone fruits grown in humid areas, cannot be excluded.
Stereochemical variations in the cyclocondensation of aldehydes with siloxydienes. An application to the erythronolide series (1982)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemical variations in the cyclocondensation of aldehydes with siloxydienes. An application to the erythronolide seriesSamuel Danishefsky, Eric R. Larson, and David AskinCite this: J. Am. Chem. Soc. 1982, 104, 23, 6457–6458Publication Date (Print):November 1, 1982Publication History Published online1 May 2002Published inissue 1 November 1982https://pubs.acs.org/doi/10.1021/ja00387a055https://doi.org/10.1021/ja00387a055research-articleACS PublicationsRequest reuse permissionsArticle Views482Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Interdisciplinary management of central nervous system metastasis and neoplastic meningitis: recent developments and future perspectives (2016)

The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis and treatment, including the occurrence, development, progression, metastasis, and treatment of oncologic disease. It covers basic, translational and clinical research related to cancer cell biology, genomics, precision medicine, oncology internal medicine, radiotherapy and radiology, obstetrics and gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Photoinduced electron transfer reactions of phthalimides (2000)

The influence of deactivation processes (like hydrogen bonding) on the photodecarboxylation of w-phthalimido potassium carboxylates was studied using a series of N-phthaloyl dipeptides. Furthermore, the decarboxylative addition of unfunctionalized carboxylates and heteroatom-functionalized carboxylates to phthalimides was developed as a highly chemoselective radical addition reaction.
Synchronized monochromator and insertion device energy scans at SLS (2010)

Synchronous monochromator and insertion device energy scans were implemented at the Surfaces/Interfaces:Microscopy (SIM) beamline in order to provide the users fast X‐ray magnetic dichroism studies (XMCD). A simple software control scheme is proposed based on a fast monochromator run‐time energy readback which quickly updates the insertion device requested energy during an on‐the‐fly X‐ray absorption scan (XAS). In this scheme the Plain Grating Monochromator (PGM) motion control, being much slower compared with the insertion device (APPLE‐II type undulator), acts as a “master” controlling the undulator “slave” energy position. This master‐slave software implementation exploits EPICS distributed device control over computer network and allows for a quasi‐synchronous motion control combined with data acquisition needed for the XAS or XMCD experiment.
IntegriDB (2015)

This paper presents IntegriDB, a system allowing a data owner to outsource storage of a database to an untrusted server, and then enable anyone to perform verifiable SQL queries over that database. Our system handles a rich subset of SQL queries, including multidimensional range queries, JOIN, SUM, MAX/MIN, COUNT, and AVG, as well as (limited) nestings of such queries. Even for tables with 105 entries, IntegriDB has small proofs (a few KB) that depend only logarithmically on the size of the database, low verification time (tens of milliseconds), and feasible server computation (under a minute). Efficient updates are also supported. We prove security of IntegriDB based on known cryptographic assumptions, and demonstrate its practicality and expressiveness via performance measurements and verifiable processing of SQL queries from the TPC-H and TPC-C benchmarks.
Materials, Designs and Standards Used in Ski-Boots for Alpine Skiing (2013)

This review article reports the recent advances in the study, design and production of ski-boots for alpine skiing. An overview of the different designs and the materials used in ski-boot construction is provided giving particular emphasis to the effect of these parameters on the final performances and on the prevention of injuries. The use of specific materials for ski-boots dedicated to different disciplines (race skiing, mogul skiing, ski-mountaineering etc.) has been correlated with the chemical and physical properties of the polymeric materials employed. A review of the scientific literature and the most interesting patents is also presented, correlating the results reported with the performances and industrial production of ski-boots. Suggestions for new studies and the use of advanced materials are also provided. A final section dedicated to the standards involved in ski-boot design completes this review article.
Novel paradigm enables accurate monthly gestational screening to prevent congenital toxoplasmosis and more (2023)

Toxoplasmosis is a major health burden for developed and developing countries, causing damage to eyes and brain, loss of life and substantial societal costs. Prompt diagnosis in gestational screening programs enables treatment, thereby relieving suffering, and leading to > 14-fold cost savings for care. Herein, we demonstrate that using an ICT that meets WHO ASSURED-criteria identifying persons with/without antibody to <i>Toxoplasma gondii</i> in sera and whole blood with high sensitivity and specificity, is feasible to use in USA clinical practice. We find this new approach can help to obviate the problem of detection of false positive anti- <i>T.gondii</i> IgM results for those without IgG antibodies to <i>T.gondii</i> when this occurs in present, standard of care, predicate USA FDA cleared available assays. Thus, this accurate test facilitates gestational screening programs and a global initiative to diagnose and thereby prevent and treat <i>T.gondii</i> infection. This minimizes likelihood of false positives (IgG and/or IgM) while maintaining maximum sensitivity. When isolated IgM antibodies are detected, it is necessary to confirm and when indicated continue follow up testing in ∼2 weeks to establish seroconversion. Presence of a positive ICT makes it likely that IgM is truly positive and a negative ICT makes it likely that IgM will be a false positive without infection. These results create a new, enthusiastically-accepted, precise paradigm for rapid diagnosis and validation of results with a second-line test. This helps eliminate alarm and anxiety about false-positive results, while expediting needed treatment for true positive results and providing back up distinguishing false positive tests.
Dynamic Localization of Tat Protein Transport Machinery Components in Streptomyces coelicolor (2012)

The Tat pathway transports folded proteins across the bacterial cytoplasmic membrane and is a major route of protein export in the Streptomyces genus of bacteria. In this study, we have examined the localization of Tat components in the model organism Streptomyces coelicolor by constructing enhanced green fluorescent protein (eGFP) and mCherry fusions with the TatA, TatB, and TatC proteins. All three components colocalized dynamically in the vegetative hyphae, with foci of each tagged protein being prominent at the tips of emerging germ tubes and of the vegetative hyphae, suggesting that this may be a primary site of Tat secretion. Time-lapse imaging revealed that localization of the Tat components was highly dynamic during tip growth and again demonstrated a strong preference for apical sites in growing hyphae. During aerial hypha formation, TatA-eGFP and TatB-eGFP fusions relocalized to prespore compartments, indicating repositioning of Tat components during the Streptomyces life cycle.
Endothelium-dependent vasodilation in the uvea of hypertensive and normotensive rats (1998)

Acetylcholine-stimulated NO-mediated vasodilation, but not basal NO-formation, was impaired in the choroid of the SHR. Furthermore, an interaction between vasoconstricting ET and acetylcholine was found in the anterior uvea of normotensive but not hypertensive rats.
Atomically Resolved Structural and Chemical Investigation of Single MXene Sheets (2015)

The properties of two-dimensional (2D) materials depend strongly on the chemical and electrochemical activity of their surfaces. MXene, one of the most recent additions to 2D materials, shows great promise as an energy storage material. In the present investigation, the chemical and structural properties of individual Ti3C2 MXene sheets with associated surface groups are investigated at the atomic level by aberration corrected STEM-EELS. The MXene sheets are shown to exhibit a nonuniform coverage of O-based surface groups which locally affect the chemistry. Additionally, native point defects which are proposed to affect the local surface chemistry, such as oxidized titanium adatoms (TiOx), are identified and found to be mobile.
P07.04 Rapid-CNS2: Rapid comprehensive adaptive nanopore-sequencing of CNS tumors, a proof of concept study (2021)

Abstract BACKGROUND The WHO classification 2021 includes multiple molecular markers for routine diagnostics in addition to histology. Sequencing setup for complete molecular profiling requires considerable investment, while batching samples for sequencing and methylation profiling can delay turnaround time. We introduce RAPID-CNS2, a nanopore adaptive sequencing pipeline that enables comprehensive mutational, methylation and copy number profiling of CNS tumours with a single third generation sequencing assay. It can be run for single samples and offers highly flexible target selection requiring no additional library preparation. MATERIAL AND METHODS Utilising ReadFish, a toolkit enabling targeted nanopore sequencing, we sequenced DNA from 22 diffuse glioma patient samples on a MinION device. Target regions comprised our Heidelberg brain tumour NGS panel and pre-selected CpG sites for methylation classification by an adapted random forest classifier. Pathognomonic alterations, copy number profiles, and methylation classes were called using a custom bioinformatics pipeline. Results were compared to their corresponding NGS panel-seq and EPIC array outputs. RESULTS Complete concordance with the EPIC array was found for copy number profiles from RAPID-CNS2. 94% pathognomonic mutations were congruent with NGS panel-seq. MGMT promoter status was correctly identified in all samples. Methylation families were detected with 96% congruence. Among the alterations decisive for rendering a classification-compatible integrated diagnosis, 97% of the alterations were consistent over the entire cohort (completely congruent in 19/22 cases and sufficient for unequivocal diagnosis in all). CONCLUSION RAPID-CNS2 provides a swift and highly flexible alternative to conventional NGS and array-based methods for SNV/Indel analysis, detection of copy number alterations and methylation classification. The turnaround time of ~4 days can be further shortened to &amp;lt;12h by altering target sizes. It offers a low-capital approach that would be cost-efficient for low throughput settings and invaluable in cases requiring immediate diagnoses.
Data from Multivalent Binding and Biomimetic Cell Rolling Improves the Sensitivity and Specificity of Circulating Tumor Cell Capture (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; We aimed to examine the effects of multivalent binding and biomimetic cell rolling on the sensitivity and specificity of circulating tumor cell (CTC) capture. We also investigated the clinical significance of CTCs and their kinetic profiles in patients with cancer undergoing radiotherapy treatment.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Patients with histologically confirmed primary carcinoma undergoing radiotherapy, with or without chemotherapy, were eligible for enrollment. Peripheral blood was collected prospectively at up to five time points, including before radiotherapy, at the first week, mid-point and final week of treatment, as well as 4 to 12 weeks after completion of radiotherapy. CTC capture was accomplished using a nanotechnology-based assay (CapioCyte) functionalized with aEpCAM, aHER-2, and aEGFR.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; CapioCyte was able to detect CTCs in all 24 cancer patients enrolled. Multivalent binding via poly(amidoamine) dendrimers further improved capture sensitivity. We also showed that cell rolling effect can improve CTC capture specificity (% of captured cells that are CK&lt;sup&gt;+&lt;/sup&gt;/CD45&lt;sup&gt;−&lt;/sup&gt;/DAPI&lt;sup&gt;+&lt;/sup&gt;) up to 38%. Among the 18 patients with sequential CTC measurements, the median CTC decreased from 113 CTCs/mL before radiotherapy to 32 CTCs/mL at completion of radiotherapy (&lt;i&gt;P&lt;/i&gt; = 0.001). CTCs declined throughout radiotherapy in patients with complete clinical and/or radiographic response, in contrast with an elevation in CTCs at mid or post-radiotherapy in the two patients with known pathologic residual disease.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Our study demonstrated that multivalent binding and cell rolling can improve the sensitivity and specificity of CTC capture compared with multivalent binding alone, allowing reliable monitoring of CTC changes during and after treatment. &lt;i&gt;Clin Cancer Res; 24(11); 2539–47. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A Jointly Optimized Variable<i>M</i>-QAM and Power Allocation Scheme for Image Transmission (2012)

We introduce an improved image transmission scheme over wireless channels with flat Rayleigh fading. The proposed scheme jointly optimizes bit power and modulation level to maximize the peak signal-to-noise ratio (PSNR) of the reconstructed image and hence improves the perceptual quality of the received image. In this optimization process, the significance of bits with regard to the overall quality of the image is exploited. The optimality of the proposed algorithm is demonstrated using the Lagrange method and verified through an iterative offline exhaustive search algorithm. For practical implementation, a look-up table is used at the transmitter for assigning the bit power and modulation level to each bit stream according to the received signal-to-noise ratio (SNR) observed at the receiver. The proposed scheme has low complexity since the look-up table is computed offline, only once, and used for any image which makes it suitable for devices with limited processing capability. Analytical and simulation results show that the proposed scheme with jointly optimized bit power and variable modulation level provides an improvement in PSNR of about 10 to 20 dB over fixed power fixed modulation (16-QAM). A further reduction in complexity is achieved by using the average signal-to-noise ratio rather than the instantaneous SNR in selecting the system parameters.