gebhart/patrepeval huggingface dataset:
Efficient Lymphocyte Migration Across High Endothelial Venules of Mouse Peyer’s Patches Requires Overlapping Expression of L-Selectin and β7 Integrin (1998)

Abstract Lymphocyte migration into lymphoid organs is regulated by adhesion molecules including L-selectin and the β7 integrins. L-selectin and α4β7 are predominantly hypothesized to direct the selective migration of lymphocytes to peripheral lymph nodes and the gut-associated lymphoid tissues, respectively. To further characterize interactions between L-selectin and β7 integrins during lymphocyte recirculation, mice deficient in both receptors (L-selectin/β7 integrin−/−) were generated. The simultaneous loss of L-selectin and β7 integrin expression prevented the majority of lymphocytes (&amp;gt;95% inhibition) from attaching to high endothelial venules (HEV) of Peyer’s patches and other lymphoid tissues during in vitro binding assays. Moreover, the inability to bind HEV eliminated the vast majority of L-selectin/β7 integrin−/− lymphocyte migration into Peyer’s patches during short-term and long-term in vivo migration assays (&amp;gt;99% inhibition, p &amp;lt; 0.01). The lack of lymphocyte migration into Peyer’s patches correlated directly with the dramatically reduced size and cellularity (99% reduced) of this tissue in L-selectin/β7 integrin−/− mice. High numbers of injected L-selectin/β7 integrin−/− lymphocytes remaining in the blood of wild-type mice correlated with markedly increased numbers of circulating lymphocytes in L-selectin/β7 integrin−/− mice. Loss of either L-selectin or the β7 integrins alone resulted in significant but incomplete inhibition of Peyer’s patch migration. Collectively, the phenotype of L-selectin/β7 integrin−/− mice demonstrates that these two receptors primarily interact along the same adhesion pathway that is required for the vast majority of lymphocyte migration into Peyer’s patches.
Infrared images target detection based on background modeling in the discrete cosine domain (2018)

Background modeling is the critical technology to detect the moving target for video surveillance. Most background modeling techniques are aimed at land monitoring and operated in the spatial domain. A background establishment becomes difficult when the scene is a complex fluctuating sea surface. In this paper, the background stability and separability between target are analyzed deeply in the discrete cosine transform (DCT) domain, on this basis, we propose a background modeling method. The proposed method models each frequency point as a single Gaussian model to represent background, and the target is extracted by suppressing the background coefficients. Experimental results show that our approach can establish an accurate background model for seawater, and the detection results outperform other background modeling methods in the spatial domain.
Characterization of a flat plate antenna for OAM generation in the millimeter frequency band (2014)

International audience
Frontiers of Clinical Proteomics - Approach of Clinical Proteomis to Search for New Marker in the Region of Digestive Disease (2008)

ポストゲノム時代となり，発現しているすべての蛋白質を網羅的に解析するプロテオーム解析の臨床応用がはじまっている．本稿ではまず，プロテオームの定義，血清プロテオームの特徴，プロテオーム解析の代表的な手法について述べた．その解析には質量分析法と二次元電気泳動法を有効に組み合わせることが不可欠である．筆者らは血清，血漿，尿，脳脊髄液などの体液や腫瘍組織などを対象とした包括的プロテオーム解析による新しい疾患マーカーの探索に取り組んでいる．これまでに得られた知見のうち，消化器・肝胆膵疾患に関連するものとして，1）習慣飲酒により減少する血清マーカーでγ-GTPのノンリスポンダーの検出にも役立つと期待されるペプチド，2）膵癌切除術前後の血清の比較プロテオーム解析により見出され，その予後に関連すると考えられるアポC1，3）食道がん切除組織の癌部・非癌部の蛍光標識二次元ディファレンス電気泳動法解析結果，について述べた．
General structural motifs of amyloid protofilaments (2006)

Human CA150, a transcriptional activator, binds to and is co-deposited with huntingtin during Huntington's disease. The second WW domain of CA150 is a three-stranded beta-sheet that folds in vitro in microseconds and forms amyloid fibers under physiological conditions. We found from exhaustive alanine scanning studies that fibrillation of this WW domain begins from its denatured conformations, and we identified a subset of residues critical for fibril formation. We used high-resolution magic-angle-spinning NMR studies on site-specific isotopically labeled fibrils to identify abundant long-range interactions between side chains. The distribution of critical residues identified by the alanine scanning and NMR spectroscopy, along with the electron microscopy data, revealed the protofilament repeat unit: a 26-residue non-native beta-hairpin. The structure we report has similarities to the hairpin formed by the A(beta)((1-40)) protofilament, yet also contains closely packed side-chains in a "steric zipper" arrangement found in the cross-beta spine formed from small peptides from the Sup35 prion protein. Fibrillation of unrelated amyloidogenic sequences shows the common feature of zippered repeat units that act as templates for fiber elongation.
Novel Coiled Tubing Post-Fracturing Cleanout of Unconventional Wells Without Downhole Motor: A Case Study from Argentina (2023)

Abstract Unconventional wells that are completed with plug-and-perf fracturing techniques require coiled tubing (CT) to mill the plugs. In Argentina, CT must mill upwards of 60 plugs to bring the well into production. The CT downhole motors are leading contributors to service quality incidents because: 1) they mill challenging materials over extended periods of time, and 2) they limit the pump rate, which reduces cleanout effectiveness and increases the risk of stuck pipe. A completion campaign selected soluble plugs instead of composite ones to improve efficiency. Initial CT runs were still completed with a milling bottomhole assembly (BHA) to address the risk of low plug solubility. However, as evidenced during the initial campaign runs, the plugs dissolved nearly completely, leaving only the steel buttons inside the well. Those buttons required a high pump rate to carry them to surface. Given the excellent plug dissolution and the fluid velocity requirement to clean out buttons, the BHA was simplified to an extended reach tool (ERT) and a customized, high-rate jetting nozzle, thus eliminating the downhole motor. The new and simplified BHA extended the pump rate limit from an average of 3.8 to 4.5 bbl/min with no adverse effect on circulating pressure. The operator observed a tenfold increase in the number of plug buttons recovered at surface, which reduced the risk of stuck CT pipe during interventions in those wells. The cleanout speed was also increased, reducing total operating time by 25%, costs, and diesel consumption. A special procedure was developed for the cases when the BHA encountered consolidated sand and plug debris during the operations, a situation that occurred an average of three times per well. To clean those accumulations, the pump rate was increased to generate high jetting energy and stronger ERT agitation, and the CT was run in hole at slow speed until tagging the solids. This procedure allowed passing all the restrictions found during the execution of the CT cleanout jobs. This approach also made it possible to clean wells with known casing deformations, a common situation in Argentina unconventional wells. Over the course of 44 wells, 13 were cleaned with the simplified BHA. This new approach addressed the two main sources of nonproductive time before initiation of the project: BHA failures decreased from 16% to 8% and no CT stuck pipe event occurred. This is the first published case study of a post-fracturing cleanout in an unconventional well without the use of a downhole motor and which, instead, combined soluble plugs and a tailored BHA. Eliminating the downhole motor in this application significantly improved operational reliability and efficiency. The use of this simplified BHA to clean the well down to total depth is only possible with a good dissolution performance of the plugs present in the well.
Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease (2010)

Adipose tissue dysfunction, featured by insulin resistance and/or dysregulated adipokine production, plays a central role not only in disease initiation but also in the progression to nonalcoholic steatohepatitis and cirrhosis. Promising beneficial effects of betaine supplementation on nonalcoholic fatty liver disease (NAFLD) have been reported in both clinical investigations and experimental studies; however, data related to betaine therapy in NAFLD are still limited. In this study, we examined the effects of betaine supplementation on hepatic fat accumulation and injury in mice fed a high-fat diet and evaluated mechanisms underlying its hepatoprotective effects. Male C57BL/6 mice weighing 25 +/- 0.5 (SE) g were divided into four groups (8 mice/group) and started on one of four treatments: control diet, control diet supplemented with betaine, high-fat diet, and high-fat diet supplemented with betaine. Betaine was supplemented in the drinking water at a concentration of 1% (wt/vol) (anhydrous). Our results showed that long-term high-fat feeding caused NAFLD in mice, which was manifested by excessive neutral fat accumulation in the liver and elevated plasma alanine aminotransferase levels. Betaine supplementation alleviated hepatic pathological changes, which were concomitant with attenuated insulin resistance as shown by improved homeostasis model assessment of basal insulin resistance values and glucose tolerance test, and corrected abnormal adipokine (adiponectin, resistin, and leptin) productions. Specifically, betaine supplementation enhanced insulin sensitivity in adipose tissue as shown by improved extracellular signal-regulated kinases 1/2 and protein kinase B activations. In adipocytes freshly isolated from mice fed a high-fat diet, pretreatment of betaine enhanced the insulin signaling pathway and improved adipokine productions. Further investigation using whole liver tissues revealed that betaine supplementation alleviated the high-fat diet-induced endoplasmic reticulum stress response in adipose tissue as shown by attenuated glucose-regulated protein 78/C/EBP homologous protein (CHOP) protein abundance and c-Jun NH(2)-terminal kinase activation. Our findings suggest that betaine might serve as a safe and efficacious therapeutic tool for NAFLD by improving adipose tissue function.
Scintillators with silicon photomultiplier readouts for high-energy astrophysics and heliophysics (2014)

Space-based gamma-ray and neutron detectors face strict constraints of mass, volume, and power, and must endure harsh operating environments. Scintillator materials have a long history of successful operation under these conditions, and new materials offer greatly improved performance in terms of efficiency, time response, and energy resolution. The use of scintillators in space remains constrained, however, by the mass, volume, and fragility of the associated light readout device, typically a vacuum photomultiplier tube (PMT). Recently developed silicon photomultipliers (SiPMs) offer gains and efficiencies similar to those of PMTs, but with greatly reduced mass and volume, high ruggedness, and no high-voltage requirements. We have therefore been investigating the use of SiPM readouts for scintillator gamma-ray and neutron detectors, with an emphasis on their suitability for space-based instruments for astrophysics and heliophysics. We present preliminary radiation hardness tests of two promising SiPM devices, and describe two concepts for SiPM-based instruments: an advanced scintillator-based Compton telescope, and a double-scatter neutron telescope suitable for measuring fast solar and magnetospheric neutrons. Supporting laboratory measurements are presented to demonstrate the feasibility of these telescope concepts.
Dynamics of the Levitron<sup>TM</sup> (1998)

The LevitronTM is an axisymmetric top magnetized parallel to its symmetry axis. It can levitate above a specially constructed magnetic base if spun rapidly enough (and, as we found, not too rapidly). We have written a complete, coupled, nondissipative Hamiltonian system that describes the dynamics of the top. The system is twelfth order and is too complicated for general analysis. We have integrated the equations of motion numerically and found a region of a two-dimensional manifold of initial conditions for which levitation persists. We find that the amplitude of the dynamic variables in the region of persistent levitation scales linearly with the initial tilt of the axis with respect to gravity. We have identified three distinct modes of failure that correspond roughly to insufficient initial spin, too large an initial tilt and too great an initial spin. Our results are in general agreement with published observations and theoretical estimates.
Virtual Environments in Healthcare: Immersion, Disruption, and Flow (2010)

*Duke University Medical Center Durham, North Carolina †Yale University New Haven, Connecticut Reprints: Jeffrey M. Taekman, MD, Department of Anesthesiology, Box 3094 Duke University Medical Center, Durham, NC 27710. E-mail: [email protected]
A collective coordinate approach to describe magnetic domain wall dynamics applied to nanowires with high perpendicular anisotropy (2015)

Several future spintronic devices are based on domain wall propagation through magnetic nanowires. Next to experiments and simulations, theoretical models are an indispensable tool to understand the magnetic domain wall mobility. In this paper, we extract the collective coordinates and derive the equations of motion that describe the domain wall dynamics directly from averaging the underlying micromagnetic equations. This way, five collective coordinates naturally emerge in the equations of motion: the domain wall displacement, the magnetization tilting, the domain wall width, effective demagnetizing factors and the domain wall asymmetry. While not predictive by itself, the approach enables a direct macroscopic interpretation of micromagnetic simulations, largely enhancing the complementarity between theory and simulations. We apply the method to study the field and current driven domain wall dynamics in nanowires with high perpendicular anisotropy. We suggest the existence of an intrinsic depinning threshold for such domain wall dynamics, even when taking into account non-adiabatic contributions to the spin-transfer torques. Furthermore, we show that the domain wall asymmetry has a resonant behaviour at high excitation strengths.
Growth of Lead Tungstate Single Crystals from Gel and Their Luminescence (2000)

Lead tungstate PbWO4 single crystals were grown from sodium metasilicate gel and water solutions of lead acetate and sodium tungstate as the reagents. Crystals grown were several micrometer in size and by X-ray diffraction measurements it was determined that they are only of the scheelite structure. No evidence of lead tungstate low temperature modification – raspite – was found. The emission properties of crystals were measured over the temperature interval 80 to 300 K and it was found that they are similar to those in PbWO4 crystals grown by the Czochralski method.
Supplementary Figure 3 from Network Analysis Identifies an HSP90-Central Hub Susceptible in Ovarian Cancer (2023)

&lt;p&gt;PDF file - 102KB, Synergistic reduction of cell viability in the cancer cell lines A1847 (A) and OVCAR-5 treated with ganetespib (GAN) in combination with cisplatin (CIS) or Paclitaxel (PAC).&lt;/p&gt;
An Injected High Frequency Current Reference Generation Method for Torque Ripple Reduction in PMSM (2021)

Permanent-magnet synchronous motors (PMSMs) are used for traction application in electric vehicles (EVs) and hybrid electric vehicles (HEVs). However, PMSMs generate vibration and acoustic noise in the connected load due to torque ripple. Torque ripple reduction techniques require accurate modeling of torque ripple and estimation of motor parameters considering magnetic saturation and magnet temperature variation. Existing approaches that consider magnetic saturation and magnet temperature variation are complicated and difficult to realize. Therefore, this paper proposes a torque ripple expression which is regarded as complex vector behavior. It can easily determine the high harmonic current reference to reduce the torque ripple by geometrically expressing the torque ripple. Furthermore, the effect of the proposed method of torque ripple reduction was experimentally verified.
The conjugative plasmid pSG5 from Streptomyces ghanaensis DSM 2932 differs in its transfer functions from other Streptomyces rolling-circle-type plasmids (1998)

The Streptomyces ghanaensis plasmid pSG5 is self-transmissible but does not form the growth-retardation zones (pocks) normally characteristic of the Streptomyces plasmid-transfer process. The complete nucleotide sequence of pSG5 was determined on both strands. pSG5 is 12,208 bp in length and has a GC content of 68 mol%. Characterization of the open reading frames by insertion and deletion analysis revealed that only a single gene, traB, is involved in the transfer of pSG5. The deduced amino acid sequence of TraB is similar to the SpoIIIE protein that is responsible for chromosome translocation during prespore formation of Bacillus subtilis. In contrast to the tra genes of the other Streptomyces plasmids, the pSG5 traB does not represent a kill function. Although pSG5 transfer is not associated with pock formation, pSG5 was shown to possess putative spd genes that are responsible for the pock phenotype of other Streptomyces plasmids. However, promoter-probe experiments revealed that the spd genes of pSG5 are not transcribed, thus explaining the deficiency in pock formation.
Long-Range Effects of Through-Bond Orbital Interactions on the Desilylation Rate of Silyl Ethers (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTLong-Range Effects of Through-Bond Orbital Interactions on the Desilylation Rate of Silyl EthersPetrus M. F. M. Bastiaansen, Romano V. A. Orru, Joannes B. P. A. Wijnberg, and Aede de GrootCite this: J. Org. Chem. 1995, 60, 19, 6154–6158Publication Date (Print):September 1, 1995Publication History Published online1 May 2002Published inissue 1 September 1995https://pubs.acs.org/doi/10.1021/jo00124a031https://doi.org/10.1021/jo00124a031research-articleACS PublicationsRequest reuse permissionsArticle Views269Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (2)»Supporting Information Supporting Information Get e-Alerts
Sub picosecond CPA-free high-power ultrafast regenerative amplifier (2008)

We demonstrate an Ytterbium diode-pumped laser with >10 W average output power, pulse repetition rate up to 100 kHz, and pulse duration around one picosecond. This system does not use the chirped pulse amplification system, yet generates much shorter pulses than typical picosecond lasers. The amplified pulses are slightly chirped, and pulse duration after external compression was as short as 400 fs. The laser combines the advantages of a picosecond amplifier, i.e. no pulse stretcher and compressor, with ultra short pulse durations which makes the laser source extremely interesting for applications such as transparent or semiconductor materials processing.
5G Trial Services Demonstration: IFoF-Based Distributed Antenna System in 28 GHz Millimeter-Wave Supporting Gigabit Mobile Services (2019)

In this paper, we demonstrate fifth-generation (5G) trial services using intermediate frequency-over-fiber (IFoF) based distributed antenna system (DAS) implemented in a 28-GHz millimeter-wave (mmWave) during Pyeongchang winter olympics. To extend mmWave-based 5G wireless coverage, IFoF-based DAS with 2 × 2 multiple-input multiple-output configuration is presented. Error vector magnitude (EVM) measurements of the 5G signal on the IF and mmWave bands are performed for both downlink and uplink transmissions over 5-km single mode fiber. The experimental results confirm that the minimum requirement for 5G signals, defined by the technical specification of the 3G partnership project, are satisfied by EVMs less than 9%. In addition, the developed IFoF-based DAS that supports 5G mobile service using 28-GHz mmWave was deployed in the city of Pyeongchang, during winter olympics. An ultra-high speed 5G data service was offered to the general public for 5G trial demonstration. The reference signals received power and data throughput of the 5G handset are measured while moving in a DAS section and 5G connected car section. We confirm that the downlink throughput of ~1 Gb/s and uplink throughput of ~200 Mb/s are achieved for the 5G trial service area in which an IFoF-based DAS is deployed. We also successfully demonstrate the 5G connected car service, which is one of the 5G key services, through deployed IFoF-based DAS. At the intersection of baseband unit and DAS deployed sections, a seamless handover is performed to smoothly support 5G-based autonomous driving service.
Some scaling issues in the active voltage control of IGBT modules for high power applications (2002)

The operation of an IGBT in its active region is a well established technique for handling short circuits, and also for voltage and dv/dt control. One important application of this technique is in the series operation of IGBTs, where voltage controllers can automatically ensure voltage sharing. In this paper we address some specific issues encountered in extending the method to large IGBT modules for high power applications. In applying the method to high power circuits, the scaling of the IGBT's internal capacitances, and other parasitic components is the main aspect that must be given particular consideration.
Flip Chip Quantum-Dot Semiconductor Disk Laser at 1200 nm (2012)

In this letter, we present the first 2-W flip chip quantum-dot (QD) semiconductor disk laser operating at 1200 nm. Compared to other techniques used for thermal management, e.g., intracavity heat spreader approach, the flip chip design preserves undisturbed optical spectrum and exhibits low intracavity losses. The latter is particularly essential for power scaling of lasers with QD gain media.