gebhart/patrepeval huggingface dataset:
188Re-HDD/lipiodol therapy for hepatocellular carcinoma: a phase I clinical trial. (2005)

After the intraarterial administration of 3.60 GBq (188)Re-HDD/lipiodol, a fast clearance of the activity appearing in the blood is observed and the predominant elimination is through urinary excretion. The tolerance as well as the preliminary response rates of the present phase I study are encouraging.
A number theory based dual transmit antennas space-time code (2002)

We construct a full data rate space-time block code over M=2 transmit-antennas and T=2 symbol periods, and we prove it achieves a transmit diversity of 2 over all 4-dimensional constellations carved from the 4-dimensional ring of complex integers Z[i]/sup 4/. Further, we optimize the coding gain of our ST code and then compare it to the Alamouti scheme (see Alamouti, S.M., IEEE Journal Selec. Areas on Communications, vol.16, p.1451-8, 1998). For N>1, we prove that our code has a better performance than the Alamouti code. The performance improvement is further enhanced when N or the size of the constellation increases. We relate the problem of ST diversity gain to algebraic number theory, and the ST coding gain optimization to the theory of simultaneous Diophantine approximation in the geometry of numbers.
Clemizole and trazodone are effective antiseizure treatments in a zebrafish model of <scp>STXBP1</scp> disorder (2022)

CRISPR-Cas9-generated zebrafish carrying a 12 base-pair deletion in stxbpb1b, a paralog sharing 79% amino acid sequence identity with human, exhibit spontaneous electrographic seizures during larval stages of development. Zebrafish stxbp1b mutants provide an efficient preclinical platform to test antiseizure therapeutics. The present study was designed to test antiseizure medications approved for clinical use and two recently identified repurposed drugs with antiseizure activity. Larval homozygous stxbp1b zebrafish (4 days postfertilization (dpf)) were agarose-embedded and monitored for electrographic seizure activity using a local field recording electrode placed in midbrain. Frequency of ictal-like events was evaluated at baseline and following 45 min of continuous drug exposure (1 mM, bath application). Analysis was performed on coded files by an experimenter blinded to drug treatment and genotype. Phenytoin (PHT), valproate (VPA), ethosuximide (ESX), levetiracetam (LEV), and diazepam (DZP) had no effect on the ictal-like event frequency in stxbp1b mutant zebrafish. Clemizole and trazodone decreased ictal-like event frequency in stxbp1b mutant zebrafish by 80% and 83%, respectively. These results suggest that repurposed drugs with serotonin receptor-binding affinities could be effective antiseizure treatments. Clemizole and trazodone were previously identified in a larval zebrafish model for Dravet syndrome. Based primarily on these preclinical zebrafish studies, compassionate-use and double-blind clinical trials with both drugs have progressed. The present study extends this approach to a preclinical zebrafish model representing STXBP1 (syntaxin-binding protein 1)-related disorders and suggests that future clinical studies may be warranted.
Estimating the structure of social networks from incomplete sets of observed information by using compressed sensing (2017)

For complex large scale networks, like social networks, it is typically impossible to observe complete information about their topology structure or link weight directly. A recent proposal, the network resonance method, can estimate the eigenvalues and eigenvectors of the Laplacian matrix for representing network structure, by using the resonance phenomena of oscillation dynamics on networks. However, it is generally not possible to observe all the eigenvalues and eigenvectors. In practice, the observed values must be assumed to include some non-negligible errors. This paper uses compressed sensing to create a new method of reconstructing the original Laplacian matrix from some of its eigenvalues and eigenvectors. Since almost all node pairs in social networks have no link, we can expect that compressed sensing will be effective. The estimated Laplacian matrix of a social network enables to us to know its structure and link weights.
A multicentre comparison between Child Pugh and Albumin‐Bilirubin scores in patients treated with sorafenib for Hepatocellular Carcinoma (2016)

Our findings support the use CP class A as an inclusion criterion, and ALBI as a stratification factor in trials of systemic therapy.
Nurses' Detection of Ineffective Inspiratory Efforts During Mechanical Ventilation (2012)

Specifically trained nurses can reliably detect ineffective inspiratory efforts during expiration.
Session details: Optimising multiprocessor and NoC platforms for performance, QoS, and reliability (2010)

No abstract available.
Arc plasma synthesis of carbon nanostructures: where is the frontier? (2011)

In this perspective paper, we critically analyse the state-of-the-art of arc discharge technique of carbon nanoparticle synthesis. We discuss improving controllability of the arc discharge synthesis of carbon nanotubes, synthesis of graphene as well as general understanding of the synthesis process. Fundamental issues related to relationship between plasma parameters and carbon nanostructure characteristics are considered. Effects of electrical and magnetic fields applied during single-wall carbon nanotube synthesis in arc plasma are explored. Finally our personal opinion on what future trends will be in arc discharge synthesis is offered.
Constraints on exotic spin-dependent interactions between electrons from helium fine-structure spectroscopy (2017)

Agreement between theoretical calculations of atomic structure and spectroscopic measurements is used to constrain possible contribution of exotic spin-dependent interactions between electrons to the energy differences between states in helium-4. In particular, constraints on dipole-dipole interactions associated with the exchange of pseudoscalar bosons (such as axions or axion-like particles) with masses ${10}^{\ensuremath{-}2}\ensuremath{\lesssim}m\ensuremath{\lesssim}{10}^{4}\mathrm{eV}$ are improved by a factor of $\ensuremath{\sim}100$. The first atomic-scale constraints on several exotic velocity-dependent dipole-dipole interactions are established as well.
Reduced epithelial sodium channel function might contribute to chronic diarrhea in inflammatory bowel disease (2009)

Introduction: The incidence of inflammatory bowel diseases (IBD) has increased significantly in the last decades. Recent data indicate that abnormal Na+ transport contributes to diarrhea, a leading symptom in patients with IBD. The aim of this study was to compare epithelial sodium channel (ENaC)-mediated ion transport in enterocytes isolated from individuals with and without IBD. Materials and methods: Crypts of Lieberkühn were isolated from biopsies taken from patients with Crohn-disease (CD) and ulcerative colitis (UC), as well as from control subjects. Cells were seeded on glass coverslips covered by Matrigel and cultured in standard medium. Cells were used for experiments 2–5 days after isolation. We used whole cell configuration of the patch clamp technique and measured ion currents in voltage clamp mode. Sodium currents were detected by blocking K+ currents with TEA and applying low Cl- concentrations in both pipette and bath solutions. Statistical analysis were performed using Student t-test (p&lt;0.05). Results: Amiloride insensitive basal current density was low in cells isolated from control subjects. Similar data were obtained in cells from CD and UC patients exhibiting even smaller inward currents then in control cells. However, these differences did not reach the level of significance. In control but not in CD and UC cells, administration of the serine protease trypsin significantly stimulated the inward currents. Trypsin shifted the reversal potential of the current towards the equilibrium potential of Na+ suggesting opening of ENaCs. In addition, the trypsin-induced Na+ current were blocked by amiloride. Discussion: Our results show that diarrhea in CD and UC could be due to impaired ENaC-mediated Na+ transport. Nevertheless, we think that alteration of other ion transport mechanisms and accumulation of local inflammatory mediators also contribute to development of symptoms in IBD.
Supplementary Figure 1 from Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth (2023)

&lt;p&gt;Radioprotection in Egr1 knockout mice was also observed at an earlier time point.&lt;/p&gt;
A Stereoselective Approach to Nucleosides and 4′-Thioanalogues from Acyclic Precursors (2009)

D- and L-nucleosides and analogues thereof, including the 4'-thionucleoside series, are one of the most important biological and pharmaceutically active classes of compounds. A novel approach to their synthesis from chiral acyclic thioaminal, bearing the nucleobase, is described.
ChemInform Abstract: Reactivity Control by Calixarenes (2011)

Abstract Review: 54 refs.
Wind direction azimuthal signature in the Stokes emission vector from the ocean surface at microwave frequencies (2001)

Abstract An ocean polarimetric emission model is presented. It is found that skewness and upwind/cross‐wind rms slopes are responsible for the first and second azimuthal harmonic, respectively. Atmospheric effects contribute significantly at low wind speeds, and at horizontal polarization at certain observation angles. Simulation results compare favorably with reported JPL–WINDRAD measurements. © 2001 John Wiley &amp; Sons, Inc. Microwave Opt Technol Lett 29: 426–432, 2001.
Optimizing DDR-SDRAM communications at C-level for automatically-generated hardware accelerators an experience with the Altera C2H HLS tool (2010)

Thanks to efficient scheduling, resource sharing, and finite-state machines generation, high-level synthesis (HLS) tools are now more mature for generating hardware accelerators with an optimized internal structure. But interfacing them within the complete design, with optimized communications, to achieve the best throughput remains hard. Expert designers still need to program all the necessary glue (in VHDL/Verilog) to get an efficient design. Taking the example of C2H, the Altera HLS tool, and of accelerators communicating to an external DDR memory, we show it is possible to restructure the application code, to generate adequate communication processes, in C, and to compile them all with C2H, so that the resulting application is highly-optimized, with full usage of the memory bandwidth. In other words, our study demonstrates that HLS tools can be used as back-end optimizers for front-end optimizations, as it is the case for standard compilation with high-level transformations developed on top of assembly-code optimizers. We believe this is the way to go for making HLS tools viable.
Landmark-based automated pronunciation error detection (2010)

We present a pronunciation error detection method for second language learners of English (L2 learners). The method is a combination of confidence scoring at the phone level and landmark-based Support Vector Machines (SVMs). Landmarkbased SVMs were implemented to focus the method on targeting specific phonemes in which L2 learners make frequent errors. The method was trained on the phonemes that are difficult for Korean learners and tested on intermediate Korean learners. In the data where non-phonemic errors occurred in a high proportion, the SVM method achieved a significantly higher F-score (0.67) than confidence scoring (0.60). However, the combination of the two methods without the appropriate training data did not lead to improvement. Even for intermediate learners, a high proportion of errors (40%) was related to these difficult phonemes. Therefore, a method that is specialized for these phonemes would be beneficial for both beginners and intermediate learners. Index Terms: automated pronunciation error detection, computer-aided pronunciation training systems, phone-level confidence scores, landmark-based SVMs
A pre-structured helix in the intrinsically disordered 4EBP1 (2014)

The eIF4E-binding protein 1 (4EBP1) has long been known to be completely unstructured without any secondary structures, which contributed significantly to the proposal of the induced fit mechanism for target binding of intrinsically disordered proteins. We show here that 4EBP1 is not completely unstructured, but contains a pre-structured helix.
Successful and unsuccessful bioaugmentation experiments monitored by fluorescent in situ hybridization (2000)

Two nitrifying reactors were operated under the same conditions except that one was twice inoculated with the aerobic denitrifying bacteria Microvirgula aerodenitrificans. The first bioaugmentation induced a transient nitrogen loss. Fluorescent in situ hybridization revealed that the bioaugmented bacteria had been rapidly eaten by protozoa. The second massive inoculation unbalanced the ecosystem and resulted in an overgrowth of protozoa and perturbations of nitrification, whereas both parameters remained stable in the non bioaugmented reactor. To enhance the incorporation of the added bacteria to indigenous flocs, two strategies were then tested. First, coagulating and flocculating substances were added to the reactor just after bioaugmentation and second, the bacteria were embedded in alginate beads before inoculation. The latter strategy gave the best results. After break-up of the beads, alginate fragments, containing microcolonies of M. aerodenitrificans, were found to be incorporated into the existing flocs. Alginate beads offer a temporary protection against grazing and favor the adhesion of the exogenous bacterial microcolonies to the existing flocs. These beads therefore constitute a suitable bioaugmentation vector to incorporate a bacterial strain into activated sludge flocs.
Efficacy of volumetric quantification methods in 11C-PiB PET for diagnosing cardiac amyloidosis (2015)

77 Objectives 11C-Pittsburgh compound B (PiB) PET has been attempted in the diagnosis of cardiac amyloidosis. However, no standard quantification method currently exists for this imaging. In this study, we evaluated diagnostic efficacy of quantification indices including volumetric indices in PiB PET for cardiac amyloidosis. Methods A total of 29 patients who were suspected as cardiac amyloidosis and 6 normal volunteers were prospectively enrolled in this study. PiB PET/CT was obtained in all subjects and myocardial biopsy was performed in the patients. On PET images, maximal SUV (Bmax) and standard deviation (SD) of blood pool was measured in the aorta as the reference tissue. Maximal myocardial uptake was measured and expressed as myocardium-to-blood ratio (MBR). For volumetry of myocardial uptake, volumes-of-interest (VOIs) of isocontour were drawn with setting three margin thresholds; Bmax, Bmax+SD, Bmax+2SD. From these VOIs, volumes were measured and metabolic volume index (MVI) was calculated as involved volume divided by body surface area. Diagnostic efficacy of quantitative values was tested regarding pathologic confirmation, by using area under curve (AUC) in ROC analysis. Results All tested volumetric parameters including MVI by Bmax (mean 2.14 ± 1.55), Bmax+SD (mean 2.28 ± 1.28), and Bmax+2SD (mean 2.09 ± 1.52) exhibited statistical significances (P Conclusions PiB PET is an effective imaging method for diagnosing cardiac amyloidosis by using quantification indices. Among those indices, volumetric index is more effective than simple uptake measurement, probably because it can reflect involved extent of the myocardium.
Search for excited leptons in proton-proton collisions at √s=7 TeV with the ATLAS detector (2012)

Artículo escrito por un elevado número de autores, solo se referencian el que aparece en primer lugar, el nombre del grupo de colaboración, si le hubiere, y los autores pertenecientes a la UAM
Drive current enhancement in p-type metal–oxide–semiconductor field-effect transistors under shear uniaxial stress (2004)

Recent attention has been given to metal–oxide–semiconductor field-effect transistor (MOSFET) device designs that utilize stress to achieve performance gain in both n-type MOSFETs (NMOS) and p-type MOSFETs (PMOS). The physics behind NMOS gain is better understood than that of PMOS gain, which has received less attention. In this letter, we describe the warping phenomena which is responsible for the gain seen in [110] uniaxially stressed PMOS devices on [100] orientated wafers. We also demonstrate that shear uniaxial stress in PMOS is better suited to MOSFET applications than biaxial stress as it is able to maintain gain at high vertical and lateral fields.
Resonant coupling of collective intra- and intersubband excitations in a parabolically confined electron system (1992)

A wide electron system as realized in modulation-doped parabolic quantum wells is used to investigate the resonant interaction between intra- and intersubband plasmonic excitations. In contrast to a conventional quasi-two-dimensional electron system, both excitations have about the same resonance energy at finite wave vector due to a relatively low subband spacing. We use a perpendicular magnetic field to tune the intrasubband plasmon such that it energetically degenerates with the intersubband mode. In the electrical quantum limit no mode coupling is observed, whereas for the case of two occupied subbands a strong resonant interaction of both modes is reflected in anticrossing behavior.
PTV Experiments of Subcooled Boiling Flow Through a Rectangular Channel (2008)

Experiments were carried out to investigate turbulent sub-cooled boiling flow of Novec-2000 [1] refrigerant through a vertical square channel with one heated wall. Channel dimensions were selected to be similar to those encountered on a Boiling Water Reactor (BWR) channel flow, with an hydraulic diameter of Dh = 8.2mm. Flow visualization techniques such as Particle Tracking Velocimetry (PTV) and Shadowgraphy were used to measure time-average axial and normal velocities, axial and normal turbulence intensities, and Reynolds Stresses. Results are reported for hydraulic Reynolds numbers at channel inlet of 4638, 14513 and 24188 for up to thirteen wall heat fluxes (q″) ranging from 0.0 to 64.0 kW/m2. This work is an attempt to enrich the database already collected on turbulent subcooled boiling flow, with the hope that it will be useful in turbulence modeling efforts.
Visual Framing of Science Conspiracy Videos: Integrating Machine Learning with Communication Theories to Study the Use of Color and Brightness (2021)

Recent years have witnessed an explosion of science conspiracy videos on the Internet, challenging science epistemology and public understanding of science. Scholars have started to examine the persuasion techniques used in conspiracy messages such as uncertainty and fear yet, little is understood about the visual narratives, especially how visual narratives differ in videos that debunk conspiracies versus those that propagate conspiracies. This paper addresses this gap in understanding visual framing in conspiracy videos through analyzing millions of frames from conspiracy and counter-conspiracy YouTube videos using computational methods. We found that conspiracy videos tended to use lower color variance and brightness, especially in thumbnails and earlier parts of the videos. This paper also demonstrates how researchers can integrate textual and visual features in machine learning models to study conspiracies on social media and discusses the implications of computational modeling for scholars interested in studying visual manipulation in the digital era. The analysis of visual and textual features presented in this paper could be useful for future studies focused on designing systems to identify conspiracy content on the Internet.
Embedded code generation using the OSQP solver (2017)

We introduce a code generation software package that accepts a parametric description of a quadratic program (QP) as input and generates tailored C code that compiles into a fast and reliable optimization solver for the QP that can run on embedded platforms. The generated code is based on OSQP, a novel open-source operator splitting solver for quadratic programming. Our software supports matrix factorization caching and warm starting, and allows updates of the problem parameters during runtime. The generated C code is library-free and has a very small compiled footprint. Examples arising in real-world applications show that the generated code outperforms state-of-the-art embedded and desktop QP solvers.
Dynamic inflow effects in measurements and high fidelity computations (2018)

Abstract. A wind turbine experiences an overshoot in loading after for example a collective step change in pitch angle. This overshoot occurs because the wind turbine wake does not immediately reach its new equilibrium, an effect usually referred to as dynamic inflow. Analycal vortex models and actuator disc simulations predict that the time constants of this dynamic inflow effect should decrease significantly towards the blade tip. As part of the NASA Ames Phase VI experiment pitch steps have been performed on a turbine in controlled conditions in the wind tunnel. The measured aerodynamic forces from these experiments seemed to show much less radial dependency of the dynamic inflow time constants than expected when pitching towards low loading. Moreover the dynamic inflow effect seemed fundamentally different when pitching from low to high loading, and the reason for this behavior remained unclear in previous analyses of the experiment. High fidelity computational fluid dynamics and free wake vortex code computations yielded the same behavior as the experiments. In the present work these observations from the experiments and high fidelity computations are explained based on a simple vortex cylinder wake model.
Surface processes in the catalytic oxidative coupling of methane to ethane (1994)

Abstract Recent results on surface reaction steps in the oxidative coupling of methane (OCM) obtained from (1) transient experiments and (2) a microkinetic analysis are summarized. The interaction of methane and oxygen with MgO and Sm 2 O 3 surfaces was investigated by applying H/D‐ and oxygen‐isotope‐exchange reactions. The role of short‐lived adsorbed oxygen species in methane activation and product formation over MgO and Sm 2 O 3 catalysts is discussed. Furthermore, elementary reaction steps and their rate constants are derived for the oxidative conversion of methane to CO x and ethane from kinetic data for different (CaO) x (CeO 2 ) 1− x catalysts; the rate constants are related to the solid's properties, i.e. , electron and O 2− conductivity.