gebhart/patrepeval huggingface dataset:
Mutations in the Beta Propeller WDR72 Cause Autosomal-Recessive Hypomaturation Amelogenesis Imperfecta (2009)

Healthy dental enamel is the hardest and most highly mineralized human tissue. Though acellular, nonvital, and without capacity for turnover or repair, it can nevertheless last a lifetime. Amelogenesis imperfecta (AI) is a collective term for failure of normal enamel development, covering diverse clinical phenotypes that typically show Mendelian inheritance patterns. One subset, known as hypomaturation AI, is characterised by near-normal volumes of organic enamel matrix but with weak, creamy-brown opaque enamel that fails prematurely after tooth eruption. Mutations in genes critical to enamel matrix formation have been documented, but current understanding of other key events in enamel biomineralization is limited. We investigated autosomal-recessive hypomaturation AI in a consanguineous Pakistani family. A whole-genome SNP autozygosity screen identified a locus on chromosome 15q21.3. Sequencing candidate genes revealed a point mutation in the poorly characterized WDR72 gene. Screening of WDR72 in a panel of nine additional hypomaturation AI families revealed the same mutation in a second, apparently unrelated, Pakistani family and two further nonsense mutations in Omani families. Immunohistochemistry confirmed intracellular localization in maturation-stage ameloblasts. WDR72 function is unknown, but as a putative beta propeller is expected to be a scaffold for protein-protein interactions. The nearest homolog, WDR7, is involved in vesicle mobilization and Ca2+-dependent exocytosis at synapses. Vesicle trafficking is important in maturation-stage ameloblasts with respect to secretion into immature enamel and removal of cleaved enamel matrix proteins via endocytosis. This raises the intriguing possibility that WDR72 is critical to ameloblast vesicle turnover during enamel maturation.
Interferon-Alpha Induces Transient Suppressors of Cytokine Signalling Expression in Human T Cells (2001)

The suppressors of cytokine signalling (SOCS) proteins comprise a newly identified family of negative feedback regulators of cytokine signalling. SOCS expression is differentially induced upon cytokine stimulation in different cell types. Here we show that interferon-alpha (IFNalpha) is a potent inducer of SOCS expression in human T cells, as high expression of CIS, SOCS-1, SOCS-2, and SOCS-3 was detectable after IFNalpha stimulation. After 4 h of stimulation, CIS, SOCS-1, and SOCS-3 expression had returned to baseline levels, whereas SOCS-2 expression had not declined. In contrast, after IL-2 induction neither CIS, SOCS-1, nor SOCS-2 expression levels declined after 6 h. In conclusion, we provide the first evidence that IFNalpha induces SOCS expression in human T cells. Moreover, we show that IFNalpha and IL-2 induce distinct patterns of expression kinetics, suggesting that dynamic changes in cytokine sensitivity might be mediated via induction of SOCS expression with different kinetics in T cells.
Supplementary Figure 3 from Advanced Age Increases Immunosuppression in the Brain and Decreases Immunotherapeutic Efficacy in Subjects with Glioblastoma (2023)

&lt;p&gt;Supplementary Figure 3. Advanced age is associated with decreased overall survival (OS) among both men and women with glioblastoma (GBM).&lt;/p&gt;
Cascaded phase shift and amplitude modulation in a feedback-like phase mismatch configuration (2003)

Summary form only given. In the past few years, cascaded /spl chi//sup (2)/:/spl chi//sup (2)/ processes have been extensively studied and several device designs have been proposed to optimize the nonlinear phase shift (NLPS) of the fundamental beam. Here, we present an alternative approach to these designs by introducing a phase-mismatch (PM) distribution related to the evolution of the amplitude of the second harmonic field generated with the considered PM distribution, during the propagation of the fundamental beam at a given input intensity and wavelength.
Learning Distributed Representations of Symbolic Structure Using Binding and Unbinding Operations. (2018)

Widely used recurrent units, including Long-short Term Memory (LSTM) and Gated Recurrent Unit (GRU), perform well on natural language tasks, but their ability to learn structured representations is still questionable. Exploiting Tensor Product Representations (TPRs) --- distributed representations of symbolic structure in which vector-embedded symbols are bound to vector-embedded structural positions --- we propose the TPRU, a recurrent unit that, at each time step, explicitly executes structural-role binding and unbinding operations to incorporate structural information into learning. Experiments are conducted on both the Logical Entailment task and the Multi-genre Natural Language Inference (MNLI) task, and our TPR-derived recurrent unit provides strong performance with significantly fewer parameters than LSTM and GRU baselines. Furthermore, our learnt TPRU trained on MNLI demonstrates solid generalisation ability on downstream tasks.
Coefficients of dynamic friction as a function of temperature, pressure, and velocity for several polyethylene resins (1995)

Abstract The coefficient of dynamic friction is often the controlling factor for solids conveying, pressure generation, and thermal decomposition of a resin in the feed section of a single‐screw plasticating extruder. The coefficients of friction are, however, very poorly understood, and the interpretation of the measurements are complicated by the dissipation of frictional energy at the sliding interface. A new instrument was recently built to help understand dynamic friction, and a numerical technique was developed to estimate the interface temperture. Coefficients of dynamic friction for several polyethylene resins are presented in this paper as a function of the surface temperature, pressure, and velocity. The relationship of the data with respect to the extrusion process is discussed.
High current, thin silicon-on-ceramic solar cell (1999)

Thin-film polycrystalline silicon solar cells offer the potential to achieve 19% efficient photovoltaic power conversion. Well-designed, 20-100 micron thick, thin-film silicon solar cells can achieve high efficiency by employing light trapping and back surface passivation. Low cost is achieved by minimizing the amount of feedstock silicon required per watt of power output. Electrically insulating supporting substrates enable monolithic, series-connected submodules. A solar cell device comprised of a 20 micron thick layer of silicon grown on an insulating ceramic substrate, designed to effect light-trapping and back surface passivation, has resulted in an independently verified short circuit current of 25.8 mA/cm/sup 2/. Analysis of the spectral response of the solar cell indicates the presence of both light-trapping and back surface passivation with an effective diffusion length in excess of twice the device thickness.
An approach to novel fused triazole or tetrazole derivatives starting from benzimidazo[1,2‐<i>a</i>]quinazoline‐5(7<i>H</i>)‐one and 5,7‐dihydro‐5‐oxopyrido[3′,2′:5,6]pyrimido[1,2‐<i>a</i>]benzimidazole (2002)

Abstract The synthetic potential of the title compounds benzimidazo[1,2‐ a ]quinazoline‐5(7 H )‐one 2a and 5,7‐dihydro‐5‐oxopyrido[3′,2′:5,6]pyrimido[1,2‐ a ]benzimidazole 2b for the construction of novel polyhetero‐cyclic frameworks is reported. Compounds 2a,b , by conversion into their thio analogues 3a,b , were used for the synthesis of tetrazole ( 5a,b ) and triazole ( 7a,b ) derivatives, as well as for an unexpected synthesis of tri‐azoles 8a,b , isomers of 7a,b , resulting from the occurrence of a Dimroth rearrangement.
Supplementary Figures 1-6 from The Decline in U.S. Cancer Mortality in People Born since 1925 (2023)

Supplementary Figures 1-6 from The Decline in U.S. Cancer Mortality in People Born since 1925
Effects of replacing thiophene with 5,5-dimethylcyclopentadiene in alternating poly(phenylene), poly(3-hexylthiophene), and poly(fluorene) copolymer derivatives (2015)

Replacing alternating thiophene repeat units with 5,5-dimethylcyclopentadiene alternatives influences the physicochemical properties of π-conjugated copolymers.
No association between the COMT Val158Met polymorphism and the long‐term clinical response in obsessive–compulsive disorder in the Japanese population (2015)

The present case-control/pharmacogenetic study did not provide clear evidence that the COMT Val158Met polymorphism is a predictor of OCD or of OCD patients' clinical responses.
Identification of a novel K-channel gene (KC22) that is highly expressed in distal tubule of rabbit kidney (1993)

The Shaker gene family encodes voltage-gated K channels. Five partial-length Shaker-like cDNAs (KC2, 4, 10, 19, and 22) were previously isolated from rabbit kidney using polymerase chain reaction (PCR) [G. V. Desir, E. Hamlin, A.H. Puente, R.F. Reilly, F. Hiledebrandt, and P. Igarashi. Am. J. Physiol. 262 (Renal Fluid Electrolyte Physiol. 31): F151-F157, 1992]. We now report the cloning of another Shaker-like cDNA (KC6) from rabbit kidney and the identification of one isoform that is highly expressed in rabbit distal tubule cells grown in culture. A partial-length cDNA (859 bp) for KC6 was isolated by PCR amplification of rabbit kidney cDNA using Shaker-specific degenerate primers. KC6 was most similar to the rat brain clone RBK2 (77% amino acid identity) and to the rabbit clone KC19 (78% amino acid identity). Transcript levels for KC2, 4, 6, 10, 19, and 22 were quantified using the ribonuclease protection assay. Transcripts for all six isoforms were detected in renal tissues. KC22 was the most abundant isoform in kidney cortex and medulla (20- to 40-fold greater than the other isoforms). Furthermore, KC22 expression levels were fivefold higher in primary cultures of rabbit distal convoluted tubules and connecting tubules than in whole kidney cortex. Although the partial-length sequence for KC22 represents the most conserved regions in the Shaker gene family it only has 35-88% amino acid identity with other Shaker channels, suggesting that KC22 represents a novel isoform. In contrast, KC4 and KC19 (less abundant in kidney than KC22) are highly homologous to the rat brain clones RBK1 and RBK2, respectively (97% amino acid identity).(ABSTRACT TRUNCATED AT 250 WORDS)
Hydrophobic peptide mapping of clinically relevant heptathelical membrane proteins by capillary electrophoresis (1997)

The structural investigation of G protein-coupled receptors has been hindered by the lack of techniques to effectively resolve the hydrophobic peptides obtained by chemical or proteolytic cleavage, as well as the minute amounts of protein typically isolated. We have developed a capillary electrophoresis method for efficient separation of hydrophobic peptides using a cyanogen bromide digest of bacteriorhodopsin as a model for these clinically important membrane proteins. This procedure includes (i) solubilization of the protein digest in acetic acid; and (ii) electrophoresis using an acetic acid-based buffer system augmented by acetonitrile and hexane sulfonic acid, in a Polybrene-coated fused silica capillary. The potential for detection sensitivity to be increased at least 100-fold by use of on-line solid-phase extraction on C18-silica is shown. This approach is potentially useful for peptide fingerprinting of sparse and extremely hydrophobic membrane receptors.
Network Duality for Multiuser MIMO Beamforming Networks and Applications (2007)

For any multiple-input multiple-output (MIMO) network with linear beamformers, it is shown that there exists a dual network that attains the same signal-to-interference-plus-noise ratio (SINR) performance. This network duality concept is a generalization of the virtual uplink concept investigated by Rashid-Farrokhi . We first develop the dual relation using a generic duality theory in linear programming. This approach naturally leads to the construction of a dual network, and provides machinery for handling a generalized cost function. We then consider the joint MIMO beamforming and power control problem with individual SINR constraints. We apply the network duality to this problem and propose a high-performance iterative algorithm which, compared with past centralized approaches, has improved convergence behavior. Finally, we propose a simpler distributed version of the algorithm tailored for a cellular downlink. This algorithm can be readily implemented in a distributed fashion, since it does not require information exchange between base stations. The algorithm achieves performance close to that of centralized ones, and outperforms other decentralized approaches available in the literature
KOLKO, Gabriel, Un siècle de guerres. Québec/Paris, Les Presses de l'Université Laval/L'Harmattan, 2000, 471 p. (2001)

KOLKO, Gabriel, Un siècle de guerres. Québec/Paris, Les Presses de l'Université Laval/L'Harmattan, 2000, 471 p.. An article from journal Études internationales (Les relations Civilo-Militaires : transfert de normes et coopération démocratique), on Érudit.
Integrated tungsten nanofiber field emission cathodes selectively grown by nanoscale electron beam-induced deposition (2005)

We report on the fabrication and operation of integrated field emission cathodes containing single tungsten (W) nanofibers selectively grown by nanoscale electron beam induced deposition (EBID). A nonorganometallic precursor, WF6, was used to deposit metallic W fibers. Vacuum electrical testing reveals electrons were successfully extracted from the W nanofiber tip and were collected by a phosphor anode. Direct current versus voltage (I–V) curves exhibited Fowler–Nordheim behavior, indicating the occurrence of cold field emission. Electrical testing of these devices indicated that EBID direct-write is a promising technique for direct production or repair of field emission cathodes.
Functional Plasticity of Language Confirmed with Intraoperative Electrical Stimulations and Updated Neuronavigation: Case Report of Low-Grade Glioma of the Left Inferior Frontal Gyrus (2014)

Removal of glioma from the dominant side of the inferior frontal gyrus (IFG) is associated with a risk of permanent language dysfunction. While intraoperative cortical and subcortical electrical stimulations can be used for functional language mapping in an effort to reduce the risk of postoperative neurological impairment, the extent of resection is limited by the functional boundaries. Recent reports proposed that a two-stage surgical approach for low-grade glioma in eloquent areas could avoid permanent deficits via the functional plasticity that occurs between the two operations. The report describes a patient with World Health Organization (WHO) grade II oligoastrocytoma in the left IFG, in functional plasticity of language occurred in the interval between two consecutive surgeries. Intraoperative electrical stimulations suggested that a language area and related subcortical fiber crossed the pre-central sulcus during tumor progression owing to functional plasticity. In the present case, we integrated neurophysiological data into the intraoperative neuronavigation system. We also confirmed the peri-lesional shift of language area and related subcortical fiber on image findings. Consequently, the tumor was sub-totally removed with two separate resections. Permanent language disturbance did not occur, and this favorable outcome was attributed to functional plasticity. The present experience sustains the multistage approach for low-grade gliomas in the language area. A combination of intraoperative electrical stimulations and updated neuronavigation may facilitate the characterization of brain functional plasticity.
Synthesis of porphyrins for metal deposition studies in molecular information storage applications (2007)

Porphyrins may serve as the active charge-storage medium in memory chips. A series of 14 porphyrins (trans-A 2 B 2 , trans-AB 2 C, or A 4 type; free base, copper or zinc chelate) has been synthesized for investigation of metal deposition on porphyrin monolayers. Each trans-AB 2 C porphyrin is equipped with a surface attachment group and a distal functional group (or flanking functional groups). The surface attachment groups include S-acetylthiomethyl, hydroxymethyl, TMS-ethynyl, allyl, and triallylmethyl; the functional groups include amino, cyano, dipyrrin-5-yl, formyl, and nitro; all of which are attached to the p-position of a porphyrin meso-phenyl group. Two non-redox-active triallylmethyl-substituted arenes were also prepared for use as control compounds.
Competitive Reductive Elimination of C-H and Si-H Bonds from IrH(SiHPh2)(CO)(mes)(dppe). Comparison of the Kinetic Activation Parameters for Reductive Eliminations in IrIII(dppe) Complexes (1995)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCompetitive Reductive Elimination of C-H and Si-H Bonds from IrH(SiHPh2)(CO)(mes)(dppe). Comparison of the Kinetic Activation Parameters for Reductive Eliminations in IrIII(dppe) ComplexesBrian P. Cleary, Rajeev Mehta, and Richard EisenbergCite this: Organometallics 1995, 14, 5, 2297–2305Publication Date (Print):May 1, 1995Publication History Published online1 May 2002Published inissue 1 May 1995https://pubs.acs.org/doi/10.1021/om00005a031https://doi.org/10.1021/om00005a031research-articleACS PublicationsRequest reuse permissionsArticle Views139Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Terahertz-induced optical birefringence in liquid water (2017)

We have observed optical birefringence in neat water induced by single-cycle intense terahertz pulses. The refractive index changes are explained by the electronic polarizability modulated by molecular orientation driven by the strong terahertz electric field.
An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma (2019)

Megakaryoblastic leukemia 1 (MKL1) is a coactivator of serum response factor and together they regulate transcription of actin cytoskeleton genes. MKL1 is associated with hematologic malignancies and immunodeficiency, but its role in B cells is unexplored. Here we examined B cells from monozygotic triplets with an intronic deletion in <i>MKL1</i>, two of whom had been previously treated for Hodgkin lymphoma (HL). To investigate MKL1 and B-cell responses in the pathogenesis of HL, we generated Epstein-Barr virus-transformed lymphoblastoid cell lines from the triplets and two controls. While cells from the patients with treated HL had a phenotype close to that of the healthy controls, cells from the undiagnosed triplet had increased <i>MKL1</i> mRNA, increased MKL1 protein, and elevated expression of MKL1-dependent genes. This profile was associated with elevated actin content, increased cell spreading, decreased expression of CD11a integrin molecules, and delayed aggregation. Moreover, cells from the undiagnosed triplet proliferated faster, displayed a higher proportion of cells with hyperploidy, and formed large tumors <i>in vivo</i> This phenotype was reversible by inhibiting MKL1 activity. Interestingly, cells from the triplet treated for HL in 1985 contained two subpopulations: one with high expression of CD11a that behaved like control cells and the other with low expression of CD11a that formed large tumors <i>in vivo</i> similar to cells from the undiagnosed triplet. This implies that pre-malignant cells had re-emerged a long time after treatment. Together, these data suggest that dysregulated MKL1 activity participates in B-cell transformation and the pathogenesis of HL.
Abstract CT206: EVT801, a novel selective VEGFR-3 inhibitor targeting tumor angiogenesis, started enrollment for its phase I first-in-human study (2022)

Abstract Introduction: EVT801 is a highly selective, orally available VEGFR3 inhibitor that strongly inhibits angiogenesis without inducing hypoxia, considered one of the main causes of cancer-associated immunosuppression. EVT801 has shown compelling single agent efficacy in multiple in vivo models. In addition, combination of EVT801 and Immune Checkpoint Therapy (ICT) agents shows additive effects, and thus holds promise for combination treatment without induction of hypoxia-induced-immunosuppression. A phase I clinical trial is underway. Methods: The phase I trial will consist of two sequential stages. During the first stage, EVT801 will be administered to patients with advanced solid tumors in a multiple ascending dose study using an accelerated 3+3 design (1 patient per dose until grade 2 toxicities are observed) in up to 48 patients in 8 dose levels. The primary objective is to determine the maximum tolerated dose (MTD) and recommended phase 2 dose (RP2D). Stage 2 will focus on validation of this RP2D in two 6-patient cohorts diagnosed with soft tissue sarcoma or renal cell carcinoma. These patients will participate in intensive analyses involving several biomarkers to better understand the pharmacological activity of the drug. A potential third stage, consisting of a multiple ascending dose evaluation of the combination of EVT801 with immuno-oncology drugs, may be added to the ongoing trial, pending further technical discussions with physicians and regulators. In addition to conventional measures of safety, tolerability, efficacy, and pharmacokinetics, the phase I study will employ a rich suite of histological, immunological, and radiological biomarkers to provide early insights into the activity of EVT801. Citation Format: Carlos Gomez roca, Philippe Cassier, Marie Mandron, Myriam Estrabaut, Nathalie Delesque-Touchard, Adam C. Smith, Amy Klawitter, Leesa Gentry, Pierre Fons, Michael R. Paillasse, Lise Davenne, Michael Fitzgerald, James Garner, Jean-Pierre Delord. EVT801, a novel selective VEGFR-3 inhibitor targeting tumor angiogenesis, started enrollment for its phase I first-in-human study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr CT206.