gebhart/patrepeval huggingface dataset:
Chemical Characterization and Wound Healing Property of <i>Jacaranda decurrens</i> Cham. (Bignoniaceae): An Experimental Study Based on Molecular Mechanisms (2020)

Ten compounds were identified in the extract, distributed among the classes of flavonoids and triterpenes. Treatment with FtEHJ increased the wound contraction in 24 hours, such as reduction of TNF-<i>α</i>, IL-1<i>β</i>, and IL-6 (pg/mL) cytokines in the lesion. The TGF-<i>β</i> and collagen gene expression was increased and the wound closure accelerated to nine days, with discrete inflammation, collagenization, and accented reepithelialization. Conclusions. The results obtained suggest chemical compounds present in the FtEHJ accelerates wound healing by being a gene expression modulator, and protein content of different molecules are involved in tissue repair.
Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity (2020)

Abstract Background Multiple sclerosis (MS) disease risk is associated with reduced sun exposure. This study assessed the relationship between measures of sun-exposure (vitamin D (vitD), latitude) and MS disease severity, the mechanisms of action, and effect-modification by medication and sun-sensitivity associated MC1R variants. Methods Two multi-center cohort studies (n NationMS =946, n BIONAT =991). Outcomes were the multiple sclerosis severity score (MSSS) and the number of Gd-enhancing lesion (GELs). RNAseq of four immune cell populations before and after UV-phototherapy of five MS patients. Results High serum vitD was associated with reduced MSSS ( P NationMS =0.021; P BIONAT =0.007) and reduced risk for disease aggravation ( P NationMS =0.032). Low latitude was associated with higher vitD, lower MSSS ( P NationMS =0.018), fewer GELs ( P NationMS =0.030) and reduced risk for aggravation ( P NationMS =0.044). The influence of latitude on disability seemed to be lacking in the subgroup of interferon-β treated patients (interaction- P BIONAT =0.042, interaction- P NationMS =0.053). In genetic analyses, for carriers of MC1R :rs1805008(T), who reported increased sensitivity towards sunlight ( P NationMS =0.038), the relationship between latitude und the number of GELs was inversed ( P NationMS =0.001). Phototherapy induced a vitD and type I interferon signature that was most apparent in the transcriptome of monocytes ( P =1×10 −6 ). Conclusion VitD is associated with reduced MS severity and disease aggravation. This is likely driven by sun-exposure, as latitude also correlated with disability and serum vitD. However, sun-exposure might be detrimental for sun-sensitive patients. A direct induction of type I interferons through sun-exposure could explain a reduced effect of latitude in interferon-β treated patients. This could also explain opposite effects of sun-exposure in MS and the type I interferon and sun-sensitivity-associated disease Lupus.
Beyond the Monofilament for the Insensate Diabetic Foot (2011)

Foot ulcers in patients with diabetes lead to infections, amputations, and high costs, and their prevention is a stated goal of the American Diabetes Association. To assess the benefits of various interventions on the prevention of future diabetic foot ulcers, we searched for and reviewed all randomized clinical trials (RCTs) on the prevention of diabetic foot ulcers and evaluated their efficacy and scientific validity on the basis of an established systemic grading system. Only 13 RCTs were identified. All involved secondary prevention or a mixture of primary and secondary prevention. Most were small and of poor quality, with negative studies generally being of better quality than positive studies. Of all methods proposed to prevent diabetic foot ulcers, only foot temperature-guided avoidance therapy was found beneficial in RCTs, although this needs to be validated in other populations. These observations only apply to high-risk populations, and the benefits to the general population with diabetes are unclear.

### Introduction

Diabetic foot ulcers are the cause of immense suffering and health system costs (1). The lifetime risk of a person with diabetes developing a foot ulcer may be as high as 25%, whereas the annual incidence of foot ulcers is as high as 2% (2–6). Multiple component causes, including peripheral neuropathy, peripheral vascular disease (PVD), foot deformity, and smoking, interact in the causal pathway to foot ulceration. In several cross-sectional and retrospective studies, the prevalence of PVD and peripheral neuropathy in patients was found to be as high as 40%. However, no prospective study clearly documented their relative contribution. This review is concerned primarily with clinical trials on the prevention of foot ulcers in the neuropathic, or insensate, foot.

Several physiologic measurements of the presence and degree of peripheral neuropathy have been shown to be predictive of the risk of future foot ulcer in …
Ruthenium Pincer‐Catalyzed Acylation of Alcohols Using Esters with Liberation of Hydrogen under Neutral Conditions (2010)

Abstract Acylation of secondary alcohols using non‐activated esters, in particular symmetrical esters (such as ethyl acetate), is achieved under neutral conditions with the liberation of molecular hydrogen. This unprecedented, environmentally benign reaction is homogenously catalyzed by a dearomatized ruthenium pincer PNN complex.
Enhanced blind decoding of Tardos codes with new map-based functions (2013)

This paper presents a new decoder for probabilistic binary traitor tracing codes under the marking assumption. It is based on a binary hypothesis testing rule which integrates a collusion channel relaxation so as to obtain numerical and simple accusation functions. This decoder is blind as no estimation of the collusion channel prior to the accusation is required. Experimentations show that using the proposed decoder gives better performance than the well-known symmetric version of the Tardos decoder for common attack channels.
Preface (2013)

which is one of four new journals published by the Japan Society of Mechanical Engineers (JSME).This journal is devoted to comprehensive mechanical engineering issues from fundamental aspects to practical studies including studies on applicability based on original data and important data referred from articles.The first issue of Mechanical Engineering Reviews consists of invited reviews written by the world's top-ranking researchers in each field.In these reviews, the latest original research topics are presented with reference to important results from many articles.These reviews are expected to be very attractive and informative for engineers and researchers.Mechanical Engineering Reviews aims to become the leading journal for engineers and researchers, providing a forum to share common issues, to solve practical problems through fundamental research, and to shape future directions of research.
Amplification of Coronary Arteriogenic Capacity of Multipotent Stromal Cells by Epidermal Growth Factor (2009)

These results reveal the importance of EGF in MSCs adhesion to endothelium and suggest that MSCs may be effective therapies for the stimulation of coronary collateral growth when interventions are used to increase their adhesion and homing (in vitro EGF treatment) to the jeopardized myocardium.
ARM2GC (2019)

We present ARM2GC, a novel secure computation framework based on Yao's Garbled Circuit (GC) protocol and the ARM processor. It allows users to develop privacy-preserving applications using standard high-level programming languages (e.g., C) and compile them using off-the-shelf ARM compilers, e.g., gcc-arm. The main enabler of this framework is the introduction of SkipGate, an algorithm that dynamically omits the communication and encryption cost of a gate when its output is independent of the private data. SkipGate greatly enhances the performance of ARM2GC by omitting costs of the gates associated with the instructions of the compiled binary, which is known by both parties involved in the computation. Our evaluation on benchmark functions demonstrates that ARM2GC outperforms the prior best solution by 156×.
Multifunctional Small Molecules as Potential Anti-Alzheimer’s Disease Agents (2021)

Alzheimer's disease (AD) is a severe multifactorial neurodegenerative disorder characterized by a progressive loss of neurons in the brain. Despite research efforts, the pathogenesis and mechanism of AD progression are not yet completely understood. There are only a few symptomatic drugs approved for the treatment of AD. The multifactorial character of AD suggests that it is important to develop molecules able to target the numerous pathological mechanisms associated with the disease. Thus, in the context of the worldwide recognized interest of multifunctional ligand therapy, we report herein the synthesis, characterization, physicochemical and biological evaluation of a set of five (<b>1a</b>-<b>e</b>) new ferulic acid-based hybrid compounds, namely feroyl-benzyloxyamidic derivatives enclosing different substituent groups, as potential anti-Alzheimer's disease agents. These hybrids can keep both the radical scavenging activity and metal chelation capacity of the naturally occurring ferulic acid scaffold, presenting also good/mild capacity for inhibition of self-Aβ aggregation and fairly good inhibition of Cu-induced Aβ aggregation. The predicted pharmacokinetic properties point towards good absorption, comparable to known oral drugs.
Through bit logging : A new method to acquire log data (2005)

Through Bit Logging (TBL) has been developed over the last few years by Shell and Reeves Oilfield Services (together with industry partners) as a cost-effective and operationally efficient alternative to standard wireline conveyance and LWD. In the new system, the logging tools are conveyed via the drillstring and pass into open hole through a specially designed bit, with formation evaluation data being acquired with wireline tools for surface readout or with memory tools while tripping drill pipe out of the well. The Reeves logging tools are latest technology, small diameter (2.25-inch OD) oilfield tools with low power consumption suitable for both wireline and battery-memory operations. They have completed 17,000 non-TBL operations, providing mainly quad-combo data. Reeves also have a 2.4-inch OD formation pressure tester which is run through the bit on wireline for real-time pressure evaluation. The TBL method has been tested in a number of semi-vertical wells drilled by Shell, and it is ready for commercial use. It saves tripping time, reduces open hole exposure, and it is particularly well suited as a low-cost solution for difficult well environments.
Human-Centric Autonomous Driving Based on a Two-Stage Machine Learning Algorithm (2022)

This paper presents a human-centric autonomous driving system, which is based on a two-stage machine learning algorithm. In particular, driving perception and human features are integrated to develop human-centric autonomous vehicles. Hence, we propose two-stage machine learning algorithms to identify the driver features such as age, location, sense, etc. We consider both online and offline learning to construct a two-stage distribution model and determine the relationship between the driver features and its cluster. The simulation results show the performance of the proposed two-stage learning algorithms in terms of a driver’s feature training performance.
QA with Attitude: Exploiting Opinion Type Analysis for Improving Question Answering in On-line Discussions and the News (2007)

In this paper, we explore the utility of attitude types for improving question answering (QA) on both web-based discussions and news data. We present a set of attitude types developed with an eye toward QA and show that they can be reliably annotated. Using the attitude annotations, we develop automatic classifiers for recognizing two main types of attitudes: sentiment and arguing. Finally, we exploit information about the attitude types of questions and answers for improving opinion QA with promising results. 1.
Discovery and application of check constraints in DB2 (2002)

The traditional role of integrity constraints is to protect the integrity of data, but integrity constraints can and do play other roles in databases; for example, they can be used for query optimization. In this role, they do not need to model the domain; it is sufficient that they describe regularities that are true about the data currently stored in a database. In this paper, we describe two algorithms for finding such regularities (in the syntactic form of check constraints) and discuss some of their applications in DB2. In particular, we show their use in query optimization.
Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA (2015)

Amyloid-like protein aggregation is associated with neurodegeneration and other pathologies. The nature of the toxic aggregate species and their mechanism of action remain elusive. Here, we analyzed the compartment specificity of aggregate toxicity using artificial β-sheet proteins, as well as fragments of mutant huntingtin and TAR DNA binding protein-43 (TDP-43). Aggregation in the cytoplasm interfered with nucleocytoplasmic protein and RNA transport. In contrast, the same proteins did not inhibit transport when forming inclusions in the nucleus at or around the nucleolus. Protein aggregation in the cytoplasm, but not the nucleus, caused the sequestration and mislocalization of proteins containing disordered and low-complexity sequences, including multiple factors of the nuclear import and export machinery. Thus, impairment of nucleocytoplasmic transport may contribute to the cellular pathology of various aggregate deposition diseases.
6‐Sulphatoxymelatonin Production in Breast Cancer Patients (1990)

The daily pattern of the major urinary metabolite of melatonin, 6-sulphatoxymelatonin (aMT6s), was determined in women prior to having a breast biopsy. Women with malignant tumors appeared to have significantly lower 24 h concentrations of aMT6s with a decrease in the amplitude of the rhythm compared to women with benign tumors. The amount of urinary aMT6s was dependent upon the age of the subject but was not affected by either menopausal status or body mass index. However, when the women with malignant tumors were compared with a large group of normal women of the same age their aMT6s levels were not outside the normal range. The results show that a large control group and very accurate age matching are essential when investigating melatonin production in different groups of subjects.
Adenoviral vectors for gene transfer and therapy (2004)

Due to the very efficient nuclear entry mechanism of adenovirus and its low pathogenicity for humans, adenovirus-based vectors have become gene delivery vehicles that are widely used for transduction of different cell types, especially for quiescent, differentiated cells, in basic research, in gene therapy applications, and in vaccine development. As an important basis for their use as gene medicine, adenoviral vectors can be produced in high titers, they can transduce cells in vivo with transgenes of more than 30 kb, and they do not integrate into the host cell genome. Recent advances in the development of adenoviral vectors have brought considerable progress on issues like target cell specificity and tropism modification, long-term expression of the transgene, as well as immunogenicity and toxicity in vivo, and have suggested that the different generations of non-replicative and replicative vectors available today will each suit best for certain applications.
Crystal Orientation Dependence of Macropore Formation in p-Type Silicon Using Organic Electrolytes (2000)

The crystal orientation dependence of pore formation in Si provides important information on pore formation mechanisms. In addition, the anisotropy of macropores is an important parameter for applications, especially for the microstructuring of silicon. The dependence of the macropore morphology on the orientation of p-type silicon samples was studied for various electrolytes (mostly organic) containing HF. A comparison between organic and aqueous electrolytes is given and discussed in terms of the “current-burst-model”, Carstensen et al., Mater. Sci. Engn. B 69/70, 23 (2000).
Effects of flunixin and flunixin plus prednisone on the gastrointestinal tract of dogs (1990)

Flunixin meglumine has been reported to induce gastrointestinal lesions in dogs when administered at therapeutic dosages. We administered flunixin meglumine to dogs daily for 10 days to assess the effect of this drug on the gastrointestinal tract. We also evaluated the possibility of corticosteroid potentiation of gastrointestinal toxicosis by concurrent administration of prednisone to 1 group of dogs. Dogs were monitored for gastrointestinal toxicosis by means of serial endoscopic evaluation, measurement of fecal occult blood, PCV, and total solid concentration, and by physical examination. There were 3 treatment groups of 5 dogs each. Group-1 dogs were given 2.2 mg of flunixin meglumine/kg daily, in 2 divided doses IM; group-2 dogs were given 4.4 mg of flunixin meglumine/kg daily, in 2 divided doses IM; and group-3 dogs were given 2.2 mg of flunixin meglumine/kg daily, in 2 divided doses IM plus 1.1 mg of prednisone/kg/d orally, in 2 divided doses. A fourth group of 5 dogs served as a control group. Endoscopically visible gastric mucosal lesions developed in all treated dogs within 4 days of initiating treatment. Lesions first developed in the gastric pylorus and antrum and lesions at these sites were more severe than those observed elsewhere. Dogs treated with flunixin meglumine plus prednisone developed the earliest and most severe lesions; lesion scores in group-2 dogs were higher than those in group-1 dogs. All dogs treated had occult blood in their feces by day 5 and its presence appeared to correlate more closely with endoscopic findings than did physical examination findings or changes in values for PCV or total solids.(ABSTRACT TRUNCATED AT 250 WORDS)
INTERLEUKIN-18 PLASMA LEVELS ARE INCREASED IN PATIENTS WITH SEPSIS COMPARED TO SEVERELY INJURED PATIENTS (2001)

Interleukin-18 (IL-18) appears to play a critical role in cytokine-induced organ failure during endotoxemia in animal models. Therefore, plasma samples from patients with severe trauma and sepsis were examined for the presence of IL-18. Significantly elevated plasma IL-18 concentrations were found in patients with sepsis compared to severely injured patients and healthy humans. Septic patients who died and patients with septic shock exhibited higher levels of IL-18 than survivors and septic patients without shock. In addition, septic patients with gram-positive infections had significantly higher IL-18 plasma levels than patients with gram-negative infection. These findings were confirmed by whole blood assay from healthy humans where Staphylococcus aureus markedly (P < 0.05) increased the release of IL-18 in whole blood ex vivo, while endotoxin was ineffective. Although obtained from a small patient group, these results suggest that IL-18 production may discriminate between gram-positive and gram-negative sepsis, and that increased IL-18 appearance may be associated with an adverse outcome in septic patients.
Frequency stability of wafer-scale encapsulated MEMS resonators (2005)

This paper presents an investigation of the long-term frequency stability of wafer-scale encapsulated silicon MEMS resonators. Two aspects of stability were examined: long-term stability over time and temperature-related hysteresis. Encapsulated resonators were tested over a period of 8,000 hours in constant environmental temperature of 25/spl deg/C /spl plusmn/ 0.1/spl deg/C. No measurable drift, burn-in time, or other changes in resonant frequencies were detected. Another experiment was performed to investigate the stability of the resonators with temperature cycling. The resonant frequency was measured between each cycle for more than 450 temperature cycles from -50/spl deg/C to +80/spl deg/C. Additional data is presented for short-term hysteresis measurements -10/spl deg/C to +80/spl deg/C temperature cycle. No detectable hysteresis was observed in either of the temperature cycle experiments. These series of experiments demonstrate resonant frequency stability of wafer-scale silicon based MEMS resonators.
A Human Platelet Calcium Calculator Trained by Pairwise Agonist Scanning (2015)

Since platelet intracellular calcium mobilization [Ca(t)]i controls granule release, cyclooxygenase-1 and integrin activation, and phosphatidylserine exposure, blood clotting simulations require prediction of platelet [Ca(t)]i in response to combinatorial agonists. Pairwise Agonist Scanning (PAS) deployed all single and pairwise combinations of six agonists (ADP, convulxin, thrombin, U46619, iloprost and GSNO used at 0.1, 1, and 10xEC50; 154 conditions including a null condition) to stimulate platelet P2Y1/P2Y12 GPVI, PAR1/PAR4, TP, IP receptors, and guanylate cyclase, respectively, in Factor Xa-inhibited (250 nM apixaban), diluted platelet rich plasma that had been loaded with the calcium dye Fluo-4 NW. PAS of 10 healthy donors provided [Ca(t)]i data for training 10 neural networks (NN, 2-layer/12-nodes) per donor. Trinary stimulations were then conducted at all 0.1x and 1xEC50 doses (160 conditions) as was a sampling of 45 higher ordered combinations (four to six agonists). The NN-ensemble average was a calcium calculator that accurately predicted [Ca (t)]i beyond the single and binary training set for trinary stimulations (R = 0.924). The 160 trinary synergy scores, a normalized metric of signaling crosstalk, were also well predicted (R = 0.850) as were the calcium dynamics (R = 0.871) and high-dimensional synergy scores (R = 0.695) for the 45 higher ordered conditions. The calculator even predicted sequential addition experiments (n = 54 conditions, R = 0.921). NN-ensemble is a fast calcium calculator, ideal for multiscale clotting simulations that include spatiotemporal concentrations of ADP, collagen, thrombin, thromboxane, prostacyclin, and nitric oxide.
Positron Emission Tomography and Brain Monoamine Neurotransmission - Entries for Study of Drug Interactions (2002)

Monoamine neurotransmission is a complicated process with interactions between individual neurotransmitter pathways, multiple receptors with different responses and a variety of feedback loops regulating neurotransmitter synthesis, release, reuptake and effect on receptors. The system is further affected by a range of enzymes with co-factors controlling synthesis and degradation of monoamines. Positron emission tomography (PET) has evolved to a very versatile tool for the in vivo imaging and characterisation of physiology and biochemistry. The basis for its expansion during the last years has been a rapid development of labelling methods, allowing a range of tracer molecules to be generated and used in human and research animal studies. The most important PET radionuclide is (11)C with a short half-life of approximately 20 minutes. This radionuclide is ideal for the labelling of organic molecules and for multi-tracer applications in research and drug development studies. PET has been used for a range of explorative studies on the monoamine neurotransmission, as exemplified by studies on the expression of dopamine and serotonin receptors as well as the rate of dopamine and serotonin synthesis. The present article gives examples of studies where PET has been used for the characterization of monoamine transmitter systems in experimental animals and in humans, both in healthy individuals and in patients with diseases affecting neurotransmission.