gebhart/patrepeval huggingface dataset:
Adherence to Guidelines for Breast Surveillance in Breast Cancer Survivors (2018)

<b>Background:</b> Guidelines recommend annual mammography after curative-intent treatment for breast cancer. The goal of this study was to assess contemporary patterns of breast imaging after breast cancer treatment. <b>Methods:</b> Administrative claims data were used to identify privately insured and Medicare Advantage beneficiaries with nonmetastatic breast cancer who had residual breast tissue (not bilateral mastectomy) after breast surgery between January 2005 and May 2015. We calculated the proportion of patients who had a mammogram, MRI, both, or neither during each of 5 subsequent 13-month periods. Multinomial logistic regression was used to assess associations between patient characteristics, healthcare use, and breast imaging in the first and fifth years after surgery. <b>Results:</b> A total of 27,212 patients were followed for a median of 2.9 years (interquartile range, 1.8-4.6) after definitive breast cancer surgery. In year 1, 78% were screened using mammography alone, 1% using MRI alone, and 8% using both tests; 13% did not undergo either. By year 5, the proportion of the remaining cohort (n=4,790) who had no breast imaging was 19%. Older age was associated with an increased likelihood of mammography and a decreased likelihood of MRI during the first and fifth years. Black race, mastectomy, chemotherapy, and no MRI at baseline were all associated with a decreased likelihood of both types of imaging. <b>Conclusions:</b> Even in an insured cohort, a substantial proportion of breast cancer survivors do not undergo annual surveillance breast imaging, particularly as time passes. Understanding factors associated with imaging in cancer survivors may help improve adherence to survivorship care guidelines.
Velocity constrained mobile-hapto by coordinate transformation (2011)

In this study, we propose velocity constrained mobile-hapto by coordinate transformation. Mobile-hapto is a remote control system that enables two requirements: velocity of a mobile robot is controlled by a handle robot and the reaction force of the mobile robot is fed back to the handle robot. In practice, designers have to assure safety of mobile robots because mobile robots are located in a remote place, which operators cannot perfectly recognize. Therefore, a constraint that enables velocity limitation is proposed in this study. Because coordinate transformation does not destabilize systems, stable and precise velocity constrained mobile-hapto is obtained. The validity of the proposed method is verified by simulations and experiments.
Supramolecular Catalysis in the Organic Solid State through Dry Grinding (2010)

Chemische Mechanik: Eine H-Brücken-vermittelte Selbstorganisation und mechanochemische Effekte wurden genutzt, um eine supramolekulare Katalyse im Festkörper zu bewirken. Das Zermörsern eines physikalischen Gemenges eines Olefins mit katalytischen Mengen eines ditopen Templats erwies sich als effiziente Methode für eine Cokristall-Bildung als Startpunkt des Katalysekreislaufs (siehe Schema).
Oligozoospermia with normal fertility in male mice lacking the androgen receptor in testis peritubular myoid cells (2006)

Androgens and the androgen receptor (AR) play important roles in the testes. Previously we have shown that male total AR knockout (T-AR-/y) mice revealed incomplete germ cell development and lowered serum testosterone levels, which resulted in azoospermia and infertility. However, the consequences of AR loss in particular types of testicular cells remain unclear. Using a Cre-loxP conditional knockout strategy, we generated a tissue-selective knockout mouse with the AR gene deleted in testis peritubular myoid cells (PM-AR-/y). Phenotype analyses showed that PM-AR-/y mice were indistinguishable from WT AR (AR+/y) mice with the exception of smaller testes size. PM-AR-/y mice have serum testosterone concentrations comparable with AR+/y mice. PM-AR-/y mice have oligozoospermia in the epididymis; however, fertility was normal. Although normal germ cell distribution ratio was found, total germ cell number decreased in PM-AR-/y mice. Further mechanistic studies demonstrated that PM-AR-/y mice have defects in the expression of Sertoli cells' functional marker genes such as tranferrin, epidermal fatty acid-binding protein, androgen-binding protein, and other junction genes including occludin, testin, nectin, zyxin, vinculin, laminingamma3, gelsolin, connection43, and N-cadherin. Furthermore, there were defects in peritubular myoid cell contractility-related genes such as endothelin-1, endothelin receptor A and B, adrenomedullin, adrenomedullin receptor, and vasopressin receptor 1a. Together, our PM-AR-/y mice provide in vivo evidence for the requirement of functional AR in peritubular myoid cells to maintain normal Sertoli cells function and peritubular myoid cell contractility, thus ensuring normal spermatogenesis and sperm output.
Separable roles of the <i>Pseudomonas syringae</i> pv. <i>phaseolicola</i> accessory protein HrpZ1 in ion‐conducting pore formation and activation of plant immunity (2008)

The HrpZ1 gene product from phytopathogenic Pseudomonas syringae is secreted in a type-III secretion system-dependent manner during plant infection. The ability of HrpZ1 to form ion-conducting pores is proposed to contribute to bacterial effector delivery into host cells, or may facilitate the nutrition of bacteria in the apoplast. Furthermore, HrpZ1 is reminiscent of a pathogen-associated molecular pattern (PAMP) that triggers immunity-associated responses in a variety of plants. Here, we provide evidence that the ion pore formation and immune activation activities of HrpZ1 have different structure requirements. All HrpZ1 orthologous proteins tested possess pore formation activities, but some of these proteins fail to trigger plant defense-associated responses. In addition, a C-terminal fragment of HrpZ1 retains the ability to activate plant immunity, whereas ion pore formation requires intact HrpZ1. Random insertion mutagenesis of HrpZ1 further revealed the C terminus to be important for the PAMP activity of the protein. HrpZ1 binds to plant membranes with high affinity and specificity, suggesting that the activation of plant immunity-associated responses by HrpZ1 is receptor-mediated. Our data are consistent with dual roles of HrpZ1 as a virulence factor affecting host membrane integrity, and as a microbial pattern governing the activation of plant immunity during infection.
Evaluation of the Need for Scale Inhibitor Injection During Formation Water Production in a Subsea Gas Field Using Partly PH Stabilised Mono Ethylene Glycol (2020)

Abstract A subsea gas field uses MEG with pH stabiliser and film forming corrosion inhibitor for hydrate and corrosion control. Formation water production from some of the wells is expected and when mixed with partly pH stabilised MEG, there is an increased risk for carbonate scaling in the mixing point at the wellhead and in the production pipeline. Scale calculations gives calcium carbonate saturation ratios at a level where scale formation is expected in produced water systems which indicate a need for scale inhibitor. It is assumed that precipitation of salts in MEG systems is slower than in water-based systems and a work was started to investigate if higher saturation ratios could be tolerated in a system containing MEG than in a water system without MEG. Scale testing were performed with and without MEG at relevant field conditions to evaluate if formation water can be produced without use of scale inhibitor at a low risk for scaling. Glass equipment with a mixing cell connected to short steel pipes mounted upstream and downstream of a glass coil were used in the scale testing. Calcium carbonate scale was identified by SEM/EDS on the steel pipes and the amounts of deposited calcium carbonate were found by weighing. Amounts of deposition in the tests were compared with the theoretically amounts that could precipitate. These results were further combined with deposition considerations in the piping in the field as a function of time to evaluate the risk for blocking the piping downstream the MEG injection point with calcium carbonate scale. Based on the scale testing and deposition evaluations it was concluded that use of scale inhibitor was not necessary since the risk for build-up of scale in the piping was very low.
Murine CD1d‐restricted gamma‐delta T cells respond to cardiolipin (2008)

CD1d recognizes both microbial and self‐antigens, but the nature of the endogenous lipids bound by CD1d remains poorly elucidated. Cardiolipin (CL) is a major phospholipid component of bacteria that have been shown to trigger strong CD1d‐restricted responses. CL is also present in mammalian cells, but normally hidden from the immune system because of its location in the mitochondrial inner membrane. Based on growing evidence that CD1‐restricted T cells recognize phospholipids, we hypothesized that T cells in the normal immune repertoire respond to CL. Splenocytes, or liver‐derived lymphocytes, from C57BL/6 mice were incubated with bovine heart CL or control phospholipids. Proliferation occurred exclusively with CL, in a dose‐dependent manner, and was greatest in liver‐derived cells. CL‐dependent T cell stimulation was abrogated by monoclonal anti‐CD1 antibody, but was unaffected by antibody against MHC I or II. Furthermore, CL‐dependent T cell stimulation was undetectable in cells isolated from CD1d‐deficient mice. Using flow cytometry, CL‐responsive cells were shown to express gamma‐delta T cell receptor (TCR) and to produce interferon‐gamma. These findings demonstrate that a subset of CD1d‐restricted gamma‐delta T cells responsive to CL exists in the liver of healthy mice, and suggest that these cells could play a role in T cell responses to bacteria and, potentially, to self‐CL. Supported by CIHR (JR).
Data Selection for Maximum Coverage in Sensor Networks with Cost Constraints (2014)

In many deployments of wireless sensor networks (WSNs), the primary goal is to collect and deliver data from many nodes to a data sink. This goal must be met while considering limited resources, such as battery life, in the wireless nodes. In this work, we propose considering the content of generated data to make intelligent data and node selection decisions. We formally present the problem of maximizing coverage of this collected data while restricting individual node costs to remain within a given budget and provide an algorithm that provides the optimal solution. Next we consider the related problem of finding the optimal long-term average coverage subject to average cost constraints and give its solution, which uses Lyapunov Optimization techniques. For real world implementations, we also provide computationally feasible approximation algorithms of both problems along with proven bounds on their performance, including a novel technique that uses virtual queues for the average maximum coverage problem. Finally, we provide simulation results of all proposed algorithms. These results not only demonstrate the benefits of considering data content in scheduling, but also show the advantages from using the long-term average solution and the near-optimal performance of our greedy virtual queue approximation algorithm.
Induction heat treatment and technique of bioceramic coatings production on medical titanium alloys (2015)

Prospective composite bioceramic titania coatings were obtained on intraosseous implants fabricated from medical titanium alloy VT16 (Ti-2.5Al-5Mo-5V). Consistency changes of morphological characteristics, physico-mechanical properties and biocompatibility of experimental titanium implant coatings obtained by oxidation during induction heat treatment are defined. Technological recommendations for obtaining bioceramic coatings with extremely high strength on titanium items surface are given.
Figure S3 from Medium-throughput Drug Screening of Patient-derived Organoids from Colorectal Peritoneal Metastases to Direct Personalized Therapy (2023)

&lt;p&gt;Extended data peritonoid drug testing platform, patient specific responses&lt;/p&gt;
Capturing Term Dependencies using a Sentence Tree based Language Model (2002)

We describe a new probabilistic Sentence Tree Language Modeling approach that captures term dependency patterns in Topic Detection and Tracking&amp;apos;s (TDT) Story Link Detection task. New features of the approach include modeling the syntactic structure of sentences in documents by a sentence-bin approach and a computationally efficient algorithm for capturing the most significant sentence level term dependencies using a Maximum Spanning Tree approach, similar to Van Rijsbergen&amp;apos;s modeling of document-level term dependencies.
Biased Signaling: Distinct Ligand-directed Plasma Membrane Signalosomes Using a Common RGS/G protein Core (2019)

Biased signaling occurs when different ligands that are directed at the same receptor launch different cellular outcomes. Because of their pharmacological importance, we know the most about biased ligands and little is known about other mechanisms to achieve signaling bias. In the canonical animal G protein system, endocytosis of a 7-transmembrane GPCR is mediated by arrestins to propagate or arrest cytoplasmic signaling depending on the bias. In Arabidopsis, GPCRs are not required for G protein coupled signaling because the heterotrimeric G protein complex spontaneously exchanges nucleotide. Instead, the prototype 7-transmembrane Regulator of G Signaling 1 protein AtRGS1 modulates G signaling and through ligand-dependent endocytosis, de-repression of signaling is initiated but canonical arrestins are not involved. Endocytosis initiates from two separate pools of plasma membrane: sterol-dependent domains, possibly lipid rafts, and a clathrin-accessible neighborhood, each with a select set of discriminators, activators, and newly-discovered arrestin-like adaptors. Different trafficking origins and trajectories lead to different cellular outcomes. Thus, compartmentation with its attendant signalosome architecture is a previously unknown mechanism to drive biased signaling.
Morphological and metabolic changes in transgenic wheat with altered glycerol-3-phosphate acyltransferase or acyl-acyl carrier protein (ACP) thioesterase activities (2000)

We have transformed varieties of wheat with a Pisum sativum glycerol-3-phosphate acyltransferase gene, and also with an Arabidopsis thaliana acyl-ACP thioesterase gene. Morphological (growth, organelle development) and metabolic changes (fatty acid labelling of chloroplast and non-chloroplast lipids) have been observed in transgenics with altered gene expression for either enzyme.
ChemInform Abstract: Total Synthesis of (±)‐Antheridium‐Inducing Factor (A M) of the Fern Anemia phyllitidis. (1986)

Abstract Aus dem Kupplungsprodukt (IV) ist über das Keton (VI) (Boranat‐Reduktion zu einem 8:l=Carbinol‐Epimeren‐ Gemisch) der Diazoester (X) zugänglich, dessen intramolekulare Carbenaddition das Lacton (XI) ergibt.
The systemic effect of PEG-nGO-induced oxidative stress in vivo in a rodent model (2019)

Oxidative stress (OS) plays an important role in the pathology of certain human diseases. Scientists have developed great interest regarding the determination of oxidative stress caused after the administration of nano-graphene composites (PEG-nGO). Graphene oxide sheets (GOS) were synthesized via a modified Hummer's method and were characterized by X-ray diffraction (XRD), ultraviolet-visible spectroscopy (UV), and transmission electron microscopy (TEM). The method of Zhang was adopted for cracking of GOS. Then nano-graphene oxide was PEGylated with polyethylene glycol (PEG). PEGylation of nGO was confirmed by Fourier-transform infrared spectroscopy (FTIR), UV spectroscopy and TEM. The average size distribution of nGO and PEG-nGO was determined by using dynamic light scattering (DLS). Subsequently, an in vivo study measuring a marker for oxidative stress, namely lipid peroxides, as well as antioxidant agents, including catalase, superoxide dismutase, glutathione, and glutathione S-transferase was conducted. A comparison at different intervals of time after the administration of a dose (5 mg/kg) of PEG-nGO was carried out. An increase in free radicals and a decrease in free radical scavenging enzymes in organs were observed. Our results indicated that the treatment with PEG-nGO caused an increased OS to the organs in the first few hours of treatment. However, the liver completely recovered from the OS after 4 h. Brain, heart and kidneys showed an increased OS even after 4 h. In conclusion increased OS induced by PEG-nGO could be detrimental to brain, heart and kidneys.
SU‐E‐T‐257: Risk of Radiogenic Second Cancer after Photon and Proton Craniospinal Irradiation (2012)

Proton therapy confers lower predicted risk of second cancer for the pediatric medulloblastoma patient compared with photon therapy.
Preface (1998)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceBUDDY D. RATNERBUDDY D. RATNERDepartment of Chemical Engineering and Center for Bioengineering University of Washington Seattle, WA 98195More by BUDDY D. RATNER and VLADIMIR V. TSUKRUKVLADIMIR V. TSUKRUKDepartment of Materials Science Western Michigan University Kalamazoo, MI 49008More by VLADIMIR V. TSUKRUKDOI: 10.1021/bk-1998-0694.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):July 7, 1998Publication History Published online23 July 2009Published inprint 7 July 1998Request reuse permissions Copyright © 1998 American Chemical Society. This publication is available under these Terms of Use. Scanning Probe Microscopy of Polymerspp xi-xiiACS Symposium SeriesVol. 694ISBN13: 9780841235625eISBN: 9780841216662Chapter Views148Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (249 KB) Get e-Alerts
ChemInform Abstract: HETEROATOM ACTIVATED β‐LACTAM ANTIBIOTICS: SYNTHESIS OF BIOLOGICALLY ACTIVE SUBSTITUTED N‐OXY‐3‐AMINO‐2‐AZETIDINONES (OXAMAZINS) (1984)

Abstract Aus den Aminosäure‐Derivaten (I) werden die N‐Oxy‐azetidinone (III) und (IV) hergestellt.
ChemInform Abstract: 2,4‐DINITROBENZENESULFENYLNITRENE AS A REACTIVE INTERMEDIATE (1980)

Abstract Das Sulfenamid (I) addiert sich in Gegenwart von Bleitetraacetat an trans‐Propenylbenzol (II) unter Bildung des Aziiidins (III).
Semantic Similarity and Relatedness between Clinical Terms: An Experimental Study. (2010)

Automated approaches to measuring semantic similarity and relatedness can provide necessary semantic context information for information retrieval applications and a number of fundamental natural language processing tasks including word sense disambiguation. Challenges for the development of these approaches include the limited availability of validated reference standards and the need for better understanding of the notions of semantic relatedness and similarity in medical vocabulary. We present results of a study in which eight medical residents were asked to judge 724 pairs of medical terms for semantic similarity and relatedness. The results of the study confirm the existence of a measurable mental representation of semantic relatedness between medical terms that is distinct from similarity and independent of the context in which the terms occur. This study produced a validated publicly available dataset for developing automated approaches to measuring semantic relatedness and similarity.
Handover Selection Scheme for Fixed to Mobile Handover in BcN (2006)

In this paper, we propose that mobility agent based handover selection algorithm for handover from fixed network to mobile network. We showed that the proposed handover selection algorithm has lower blocking probability.
An Automatic Equalizer Based on Forward–Flyback Converter for Series-Connected Battery Strings (2017)

This paper proposes an automatic any-cells-to-any-cells battery equalizer, which merges the forward and flyback converters through a common multiwinding transformer. The windings of the transformer are divided into two groups, which have opposite polarities. The principles of the proposed equalizer are that the equalization in one group is achieved based on forward conversion and the balancing between the two different groups is based on flyback conversion, by which the magnetic energy stored in the transformer can be automatically reset without using additional demagnetizing circuits. Moreover, only one MOSFET and one primary winding are required for each cell, resulting in smaller size and lower cost. One pair of complementary control signals is employed for all MOSFETs, and energy can be automatically and directly delivered from any high-voltage cells to any low-voltage cells without the requirement of cell monitoring circuits, thereby leading to a high balancing efficiency and speed. The proposed topology can achieve the global equalization for a long battery string through connecting the secondary sides of transformers without the need of additional components for the equalization among modules, which also overcomes the mismatching problem of multiple windings. The validity of the proposed equalizer is verified through experiments, and the balancing efficiency can reach up to 89.4% over a wide range of conditions.
Harnessing host innate immunity may combat acquired resistance to BRAFi (2014)

BackgroundNatural Killer (NK) cells are innate immunity lympho-cytes that spontaneously recognise and kill melanomacells [1]. Dacarbazine synergises with host immunity byinducing stress signals (NKG2D-L) that alert NK cells[2]. This provides an example of how cancer therapiesand host innate immunity may be combined to improvemanagement of melanoma patients. BRAF inhibitors(BRAFi) are radically changing clinical practice in mela-noma treatment because they offer unprecedented survi-val gains. However, melanoma patients nearly alwaysrelapse with drug-resistant disease after 6-12 monthsinto the treatment. While evidence is emerging thatBRAFi may modulate host immunity, the effect ofBRAFi on the cross talk between NK cells and mela-noma cells is unknown.Material and methodsBRAF-mutant melanoma cell lines 1520, SK-MEL-37 andColo38 were cultured for 4 weeks in the presence of 5μMvemurafenib. BRAFi-resistant variants were sequenced toconfirm the presence of the BRAF