gebhart/patrepeval huggingface dataset:
Abstract 4909: Novel radiation mitigators and cancer chemoprevention drugs (2014)

Abstract The possibility of a radiation disaster from a nuclear detonation or accident has existed for over 50 years and spawned much of the basic research in radiobiology in the 1950-60s. The recent Fukushima accident was yet another reminder that there remains a dire need to develop novel therapies against radiation-induced toxicities. Here we report on the development of two novel radiation countermeasure therapies: Yel001 and Yel002. These small, biologically active, drug-like molecules were uncovered in the DEL high throughput assay reducing radiation-induced cyto- and geno-toxicity in yeast. Radiation-modulating activity was further confirmed in yeast plate-based DEL Assay: addition of either Yel001 or Yel002 to irradiated cultures reduced cell death and genomic instability. Further, Yel compounds increases survival to 75% in vivo following an LD100/30 dose of ionizing radiation (IR) with the first therapeutic injection administered 24 hours post exposure followed by injections at 48,72,96, and 120 hours. Additionally, treatment with Yel001 and Yel002 compounds reduces radiation-induced leukemia from 90% to to 50% and 40% respectively. Of note, treatment with either Yel001 or Yel002 reduced spontaneous leukemia rate from 10% to 0%. Furthermore, Yel002 significantly prolonged the life of Atm deficient mice. Treatment with Yel002 following IR accelerates the recovery of the hematopoietic cells and protects stem cells after sub-lethal exposures. In addition, treatment with Yel002 reduces I131, EMS, MMS, UV, cigarette smoke extract as well as nitrogen mustard induced toxicity as well as genotoxicity showing a broad application spectrum. Proteomics shows that Yel002 induces DNA repair mediated by Atm signaling, homologous recombination, nonhomologous end joining, base excision repair, DNA damage binding proteins and chromosome segregation functions. Toxicity has not been observed in neither in vitro or in vivo administrations, even in a two generation teratogenicity assay. Overall, Yel compounds have much potential as stockpile therapies for radiation-induced lethality and cancer as well as spontaneous cancer: they are highly effective when administered up to 24hours post exposure, they reduce radiation-induced sequelae such as leukemia, and appear to have an acceptable toxicity profile. Citation Format: Robert H. Schiestl, Yelena Rivina, Michael Davoren. Novel radiation mitigators and cancer chemoprevention drugs. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4909. doi:10.1158/1538-7445.AM2014-4909
AIR POLLUTION AND BLADDER CANCER RISK IN SPAIN (2004)

ISEE-171 Introduction: Several air-pollutants, including polycyclic aromatic hydrocarbons (PAHs), have been shown to be carcinogenic. Exposure to PAHs occurs mainly through smoking (active and passive), diet, inhalation of polluted air and dermal contact in certain occupations. In a meta-analysis, we recently showed a correlation between environmental exposure to PAHs and PAH-DNA adducts (Castaño-Vinyals et al. 2004). Here, we examined whether lifetime residential air-pollution is associated with bladder cancer risk. Methods: 1226 cases and 1271 hospital controls were recruited in Spain between 1998–2001 (87% males). Information about lifetime residential history and environmental exposures, smoking, occupational history, and socio-demographic data was collected. Several residential air-pollution indices were used: proximity to industries, windows facing traffic, type and quantity of traffic and size of the city of residence. Odds ratios (OR) and 95% confidence intervals (CI) were calculated using logistic regression for all residences, combining years spent in each residence, and for the longest residence. Results were adjusted for age, gender, hospital, and pack-years. Additional adjustment for consumption of fruits and vegetables, high-risk occupation and for exposure to disinfection by-products in water did not modify results. Results: Living more than 40 years in a city with more than 100,000 population was associated with an increased risk for bladder cancer overall (OR=1.45 (1.01–2.09)) and among never-smokers (OR=1.36 (0.65–2.86)). Lower or non-significant excess risks were observed for residential proximity to an industry (OR for >25 years = 1.19 (0.87–1.64); non-smokers 1.18 (0.60–2.35)), and for number of lanes (OR= 1.49 (0.76–2.94); non-smokers 2.19 (0.70–6.90)). A small excess risk for windows facing heavy traffic streets was seen only among never-smokers (1.29, 0.70–2.40). Combinations of exposure indices did not substantially modify most results, although some were associated with higher OR. Similar results were observed for the longest residence, with an OR of 1.32 (1.03–1.68) for living close to an industry and 1.33 (1.05–1.68) for living in a big city. Discussion: City size correlates well with air-pollution measurements, and is frequently used as an indicator of air pollution. Nonetheless, subjects living in different size cities may also differ in life style, and residual confounding may occur even after adjusting for major risk factors for bladder cancer. The findings will be complemented with information on commuting-based air pollution exposures, and potential exposures from specific industries. In conclusion, moderate positive associations were found for several indices of air-pollution and bladder cancer.
ChemInform Abstract: Synthesis of Functionalized Piperidines Through a [3 + 3] Cycloaddition Strategy. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Visual adaptation of opsin genes to the aquatic environment in sea snakes (2020)

Blue shifted LWS pigments may have adapted to deep water or open water environments dominated by blue light. The evolution of opsins differs between marine mammals (cetaceans and pinnipeds) and sea snakes in two fundamental ways: (1) pseudogenization of opsins in marine mammals; and (2) large blue shifts of LWS pigments in sea snakes. It may be possible to explain these two differences at the level of photoreceptor cell composition given that cone and rod cells both exist in mammals whereas only cone cells exist in fully-aquatic sea snakes. We hypothesize that the differences in photoreceptor cell compositions may have differentially affected the evolution of opsins in divergent amniote lineages.
Redetermination and H-atom refinement of (<i>S</i>)-(+)-ibuprofen (2003)

The crystal structure of (S)-(+)-ibuprofen, C13H18O2, has been redetermined. It crystallizes in the monoclinic space group P21 with two mol­ecules in the asymmetric unit, giving a cyclic hydrogen-bonded dimer. All the H atoms were located from difference maps and refined isotropically.
High resolution Shack-Hartmann sensor based on array of nanostructured GRIN lenses (2017)

We present a novel method for the development of a micro lenslets hexagonal array. We use gradient index (GRIN) micro lenses where the variation of the refraction index is achieved with a structure of nanorods made of 2 types of glasses. To develop the GRIN micro lens array, we used a modified stack-and-draw technology which was originally applied for the fabrication of photonic crystal fibers. This approach results in a completely flat element that is easy to integrate with other optical components and can be effectively used in high refractive index medium as liquids. As a proof-of-concept of the method we present a hexagonal array of 469 GRIN micro lenses with a diameter of 20 µm each and 100% fill factor. The GRIN lens array is further used to build a Shack-Hartmann detector for measuring wavefront distortion. A 50 lens/mm sampling density is achieved.
Laparoscopic repeat liver resection after open liver resection: A comparative study from a single-centre (2018)

The findings suggest that minor LRLR after OLR is safe and comparable with minor LPLR in the present study.
Conductive polymer films for microbolometer applications (1996)

In order to maximize the responsivity of a thermal detector, the detector is often fabricated on a thin membrane which is suspended over a substrate. Maximizing responsivity requires minimizing the thermal conductance and heat capacity while keeping the thermal time constant below the bandwidth of the system; maximizing the temperature coefficient of resistance (TCR) of the sensor materials, and reducing system noise. Uniformity of the detector elements greatly impacts the performance of a focal plane array. We report here a new material for IR bolometer applications. The material is a polymer film which has been made conductive by ion implantation. Implanted films which have a thickness of 1500 angstrom may be patterned by conventional photoresist processes to form small geometry elements with dimensions of 10 to 50 micrometers. Suspended conducting polymer bridges are then formed from the implanted films by etching of a sacrificial layer of silicon dioxide. High quality films with resistivities from 400 ohms/square to 10 megaohms/square can be produced by the ion implantation technique. Temperature coefficient of resistance (TCR) as a function of implantation energy and film resistivity are presented.
Analysis of a Simple Solid Oxide Fuel Cell System with Gas Dynamic in Afterburner and Connecting Pipes (2004)

Abstract A simple solid oxide fuel cell plant is analysed based on the first law of thermodynamics approach. This system consists of a solid oxide fuel cell stack, a steam reformer, a mixer, a vaporiser, an afterburner, and two pre‐heaters. To simplify the study, the enthalpy at each node of the system is normalized with the lower heating value of the inlet fuel. A gas dynamic model for calculating the flow in the pipes connecting the system components is considered and can be used to estimate the flow velocity and friction‐induced pressure drop in the piping. Though the effect of a friction‐induced pressure drop can be significant in a sizeable integrated solid oxide fuel cell‐gas turbine power plant, it does not significantly affect the plant efficiency in this study, due to rather short piping used in this simple power system. A steady flow energy equation and the Rayleigh line flow assumption are applied to the afterburner to calculate the exit flow temperature, velocity and pressure.
Expression of Adrenomedullin (ADM) and Its Binding Sites in the Rat Uterus: Increased Number of Binding Sites and ADM Messenger Ribonucleic Acid in 20-Day Pregnant Rats Compared with Nonpregnant Rats* (1997)

RIA of nonpregnant rat uterus extracts showed 0.68 +/- 0.08 pmol/g adrenomedullin (ADM) and 3.23 +/- 0.08 pmol/g calcitonin gene-related peptide (CGRP). In the pregnant (20 days gestation) uterus, the ADM content was 0.90 +/- 0.17 pmol/g, and CGRP could not be detected. ADM messenger RNA was detected at high levels in the uterus, with a 1.8-fold increase in expression in pregnancy. Pharmacologically distinct binding sites for ADM (Bmax = 21 +/- 2 fmol/mg protein, dissociation constant = 80 +/- 6 pM), and CGRP (Bmax = 101 +/- 18 fmol/mg protein, dissociation constant = 140 +/- 20 pM) were identified in nonpregnant uterus. Competition for 125I[Tyr0]alphaCGRP binding was shown by both ADM and CGRP (8-37), whereas CGRP and CGRP (8-37) did not compete for 125I-ADM-binding sites. The density of the ADM-binding sites was 10 times greater in pregnant uterus (Bmax = 211 +/- 39 fmol/mg protein, P < 0.01) than nonpregnant uterus. CGRP receptor messenger RNA was identified in both nonpregnant and pregnant uteri. In isolated nonpregnant rat uteri, CGRP and ADM attenuated the contractile response to galanin by 77 +/- 10% and 57 +/- 10%, respectively. The responses to both CGRP and ADM were abolished by CGRP (8-37). These results demonstrate, for the first time, the presence of ADM and specific binding sites for both ADM and CGRP in the rat uterus.
Electrochemistry and spectroelectrochemistry of bismanganese biscorroles dyads (2011)

Three manganese biscorrole dyads were synthesized, physicochemically characterized and investigated as to their electrochemistry and spectroelectrochemistry in nonaqueous media. Each dyad contained the same two corroles linked in a face-to-face arrangement via one of the three different linking groups, 9,9-dimethylxanthene, anthracene or diphenylether, the exact nature of which determined the distance and possible interaction between the two metallomacrocycles. The initial compounds contained Mn ( III ) in their air stable form and were shown to exhibit two major redox processes, one being a Mn (III)/ Mn (IV) conversion and the other being either Mn ( III )/ Mn ( II ) or reduction at the conjugated macrocycle to give a Mn ( III ) corrole π-anion radical when the solvent was pyridine. The potentials and reversibility of each electron transfer reaction were shown to depend upon the solvent (pyridine, CH 2 Cl 2 , or PhCN ), type of spacer separating the two macrocycles and/or the presence or absence of axial ligation. The site of each electron transfer was assigned on the basis of spectroscopic and electrochemical data and by comparison with reactions and properties of the monocorrole ( Mes 2 PhCor)Mn which was characterized in a previous publication and also examined in the current study under the same solution conditions as the newly investigated dyads. Some electrode reactions of the dyads were followed by coupled chemical reactions and these were also elucidated in the present study.
Surgical Orthodontic Correction of a Skeletal Class Ⅲ Case Treated by Dental Decompensation Using Anchor Screws (2019)

We report a case of skeletal mandibular protrusion with dwarfed teeth treated by dental decompensation using anchor screws. The patient was a female aged 18 years and 5 months at the first visit with the chief complaint of mandibular protrusion and space between maxillary anterior teeth. She had a concave facial profile with slight midfacial concavity. ∠ANB was −6.0°, ∠SNA was 78.5° and ∠SNB was 84.5°. The intraoral view showed anterior and posterior crossbite. The molar relationship was Angle ClassⅢ. Lower incisors showed lingual inclination because of dental compensation. In the conventional treatment, labial tipping of the lower incisors was likely to generate interdental spaces in the mandibular arch with mild crowding. Subsequently, in the process of closing spaces, retroclination of the incisors was frequently seen. In the present case, we used orthodontic anchor screws to maintain the lower incisor angle during presurgical orthodontic treatment. After 14 months of preoperative orthodontic treatment, Le FortⅠ osteotomy and intraoral vertical osteotomy（IVRO）were performed. As a result, the mandibular incisors were inclined labially by 7.0°. The posterior part of the maxilla was moved superiorly by 4.5mm and the mandible was set back by 11.5mm at the menton. The crossbite and concave facial profile were improved by the appropriate amount of mandibular set-back. Additionally, condylar movement and incisal paths（opening and closing, lateral excursive movements）were also improved at 25 months after the initiation of retention.
Project Status and Research Plans of 500 TPD CO2 Capture and Sequestration Demonstration at Alabama Power's Plant Barry (2013)

Southern Company and Mitsubishi Heavy Industries Ltd. (MHI) successfully started the world's largest (500 metric TPD) carbon capture plant MHI's KM-CDR® on a coal-fired power plant in June 2011 at Alabama Power's Plant Barry. The captured CO2 is transported via pipeline approximately 12 miles to Citronelle oil field where it is injected into the Paluxy formation, a saline reservoir, for storage. This part of the CCS demonstration project is the DOE funded Southeast Regional Carbon Sequestration Partnership (SECARB) phase III Anthropogenic Test. This paper will include the status and results to date of this demonstration project along with research plans associated with the 500 TPD CO2 capture facility.
Characterization of a chemostable serine alkaline protease from Periplaneta americana (2013)

Several important properties of a serine protease from P. Americana were revealed. Moreover, insects can serve as excellent and alternative source of industrially important proteases with unique properties, which can be utilized as additives in detergents, stain removers and other bio-formulations. Properties of the P. americana protease accounted in the present investigation can be exploited further in various industrial processes. As an industrial prospective, identification of enzymes with varying essential properties from different insect species might be good approach and bioresource.
pH-Switchable Phase-Transfer Agents for Host Cell Protein Rejection in the Cascaded Biocatalytic Synthesis of an Active Pharmaceutical Ingredient (2022)

Given the increased reliance on multienzymatic cascades to synthesize biologically inspired small molecule drug candidates, the pharmaceutical industry requires efficient strategies to control immunogenic protein impurities in active pharmaceutical ingredients. Despite advances in directed enzyme evolution and biocatalysis, it is still economical to use unpurified enzymes overexpressed in host cell lysates in manufacturing processes. Due to similar solubility profiles between protein impurities and the pharmaceutical, separation strategies relying on solubility differences (direct crystallization from water or extraction) often fail. Leveraging the rapid generation of modular acid–base pairs, we describe a pH-responsive extraction strategy using tertiary ammonium phase-transfer agents for efficient purification and isolation of hydrophilic immuno-oncology drug candidate MK-1454 from an aqueous biocatalytic cascade containing crude E. coli cell lysates. We demonstrate this technique to isolate several hundred grams of MK-1454 with undetectable protein impurities for human administration in clinical trials. We further show that this extraction technique is driven by reverse micellization, and may be generally applied to the purification of other hydrophilic small molecules.
Object‐oriented analysis and design of the Message Passing Interface (2001)

Abstract The major contribution of this paper is the application of modern analysis techniques to the important Message Passing Interface standard, work done in order to obtain information useful in designing both application programmer interfaces for object‐oriented languages, and message passing systems. Recognition of ‘Design Patterns’ within MPI is an important discernment of this work. A further contribution is a comparative discussion of the design and evolution of three actual object‐oriented designs for the Message Passing Interface ( MPI‐1SF ) application programmer interface (API), two of which have influenced the standardization of C++ explicit parallel programming with MPI‐2, and which strongly indicate the value of a priori object‐oriented design and analysis of such APIs. Knowledge of design patterns is assumed herein. Discussion provided here includes systems developed at Mississippi State University (MPI++), the University of Notre Dame (OOMPI), and the merger of these systems that results in a standard binding within the MPI‐2 standard. Commentary concerning additional opportunities for further object‐oriented analysis and design of message passing systems and APIs, such as MPI‐2 and MPI/RT, are mentioned in conclusion. Connection of modern software design and engineering principles to high performance computing programming approaches is a new and important further contribution of this work. Copyright © 2001 John Wiley &amp; Sons, Ltd.
Antimonide-based approaches for long-wavelength VCSELs (2002)

We demonstrate an optically-pumped all-epitaxial 1.56 /spl mu/m VCSEL on an InP substrate which combined a simple InGaAs active region with AlAsSb-AlGaAsSb mirror stacks. The AlGaAsSb material system is well-suited for fabrication of high-reflectivity DBRs due to a significantly higher refractive index contrast than achievable using InAlGaAsP, particularly at 1.55 /spl mu/m.
An experimental slow frequency-hopped personal communication system for the proposed U.S. 1850-1990 MHz band (2002)

An operational, prototype 1.8 GHz personal communication system employing the access technique of slow frequency-hopped CDMA is described. This system was designed to permit true vehicular/portable mobility with larger cells than conventional PCS proposals would allow while providing for the existence of a lower-cost PCS which would be operable in truly pedestrian-only environments. In the paper, the modem architecture, algorithms, and performance are discussed. The system has been found to yield excellent performance on a variety of channels characteristic of expanded PCS environment at a reasonable level of hardware complexity.
Photodecomposition of a commercial polybrominated biphenyl (PBB) fire retardant: high-resolution gas chromatographic analysis (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPhotodecomposition of a commercial polybrominated biphenyl (PBB) fire retardant: high-resolution gas chromatographic analysisLarry W. Robertson, Brock Chittim, Stephen H. Safe, Michael D. Mullin, and Cynthia M. PochiniCite this: J. Agric. Food Chem. 1983, 31, 2, 454–457Publication Date (Print):March 1, 1983Publication History Published online1 May 2002Published inissue 1 March 1983https://pubs.acs.org/doi/10.1021/jf00116a071https://doi.org/10.1021/jf00116a071research-articleACS PublicationsRequest reuse permissionsArticle Views70Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts