gebhart/patrepeval huggingface dataset:
MCSE: Multimodal Contrastive Learning of Sentence Embeddings (2022)

Learning semantically meaningful sentence embeddings is an open problem in natural language processing. In this work, we propose a sentence embedding learning approach that exploits both visual and textual information via a multimodal contrastive objective. Through experiments on a variety of semantic textual similarity tasks, we demonstrate that our approach consistently improves the performance across various datasets and pre-trained encoders. In particular, combining a small amount of multimodal data with a large text-only corpus, we improve the state-of-the-art average Spearman's correlation by 1.7%. By analyzing the properties of the textual embedding space, we show that our model excels in aligning semantically similar sentences, providing an explanation for its improved performance.
Nanoscale surface electrical properties of zinc oxide films investigated by conducting atomic force microscopy (2007)

Abstract In this study, conducting atomic force microscopy was employed to investigate the nanoscale surface electrical properties of zinc oxide (ZnO) films prepared by pulsed laser deposition (PLD) at different substrate temperatures for use as anode materials in polymer light‐emitting diodes. The results show that the surface conductivity distribution of ZnO is related to its surface structure. At substrate temperatures of 150–200°C, the conducting regions may cover over 90% of the ZnO thin‐film surface, thus providing the best local conductivity. Moreover, heating at substrate temperatures of above 250°C can effectively make the conductivity on the ZnO surface uniform. In particular, at substrate temperatures of around 300°C, the conducting regions where currents are between 1 and 2 μA may cover as much as 83% of the surface, and furthermore, the transmission ratio in the visible range is higher than 80%. This is a rather ideal production temperature for the PLD for ZnO films. Microsc. Res. Tech., 2008. © 2007 Wiley‐Liss, Inc.
(2<i>Z</i>)-3-(4-Fluoroanilino)-1-(5-hydroxy-3-methyl-1-phenyl-1<i>H</i>-pyrazol-4-yl)but-2-en-1-one (2012)

The central carbonyl group in the title compound, C(20)H(18)FN(3)O(2), forms amine-hy-droxy N-H⋯O and hy-droxy-hy-droxy O-H⋯O hydrogen bonds, leading to two S(6) rings. The N-bound phenyl ring is coplanar with the five-membered ring to which it is attached [dihedral angle = 6.27 (10)°], but an overall twist in the mol-ecule is evident, the dihedral angle between the terminal phenyl and benzene rings being 27.30 (10)°. Mol-ecules aggregate into a three-dimensional architecture via C-H⋯F, C-H⋯O and C-H⋯π inter-actions.
Computer simulation of lower limb postocclusive hyperaemia. In : Advances in vascular imaging and photoplethysmography. (eds. Schultz-Ehrenburg U. and Blazek V.) (1995)

Computer simulation of lower limb postocclusive hyperaemia. In : Advances in vascular imaging and photoplethysmography. (eds. Schultz-Ehrenburg U. and Blazek V.)
Glaucoma discrimination of segmented cirrus spectral domain optical coherence tomography (SD-OCT) macular scans (2012)

SD-OCT GCIP and GCC measurements showed similar glaucoma diagnostic ability and were comparable with that of cpRNFL.
RESULTS OF A PROSPECTIVE TRIAL TO COMPARE NORMAL URINE SUPERSATURATION IN CHILDREN AND ADULTS (2005)

There are significant differences in the normal ranges of urine chemistries in children and adults. An understanding of normal supersaturation values may allow metabolic abnormalities in stone-forming children to be more precisely diagnosed and treated.
Administration time-dependent effects of valsartan on ambulatory blood pressure in nondipper patients with grade 1?2 essential hypertension (2004)

Journal Article P-211: Administration time-dependent effects of valsartan on ambulatory blood pressure in nondipper patients with grade 1–2 essential hypertension Get access Ramon C. Hermida, Ramon C. Hermida 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar Carlos Calvo, Carlos Calvo 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar Diana E. Ayala, Diana E. Ayala 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar Maria J. Dominguez, Maria J. Dominguez 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar Manuel Covelo, Manuel Covelo 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar Artemio Mojon, Artemio Mojon 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jose R. Fernandez, Jose R. Fernandez 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar Jose E. Lopez Jose E. Lopez 1Bioengineering and Chronobiology Labs., University of Vigo, Vigo, Spain; Hypertension and Vascular Risk Unit, Hospital Clinico Universitario, Santiago de Compostela, Spain. Search for other works by this author on: Oxford Academic PubMed Google Scholar American Journal of Hypertension, Volume 17, Issue S1, May 2004, Page 111A, https://doi.org/10.1016/j.amjhyper.2004.03.286 Published: 01 May 2004
Quantum Hall Ferromagnetism in the Presence of Tunable Disorder (2011)

In this Letter, we report our recent experimental results on the energy gap of the ν=1 quantum Hall state (Δ(ν=1)) in a quantum antidot array sample, where the effective disorder potential can be tuned continuously. Δ(ν=1) is nearly constant at small effective disorders, and collapses at a critical disorder. Moreover, in the weak disorder regime, Δ(ν=1) shows a B(total)(1/2) dependence in tilted magnetic field measurements, while in the strong disorder regime, Δ(ν=1) is linear in B(total), where B(total) is the total magnetic field at ν=1. We discuss our results within several models involving the quantum Hall ferromagnetic ground state and its interplay with sample disorder.
Impact of Elevated Base Stations on the Ultra-Dense Networks (2018)

In this letter, we examine the impact of the elevated base stations (BSs) on the performance of ultra-dense networks (UDNs). To this end, we first model the channel between an elevated BS and typical user equipment as a 3-D probabilistic line-of-sight channel by considering the height of BSs. Using stochastic geometry, we then derive the expression for the coverage probability of our considered UDNs. Finally, through numerical results, we show how the coverage probability can be maximized by judiciously selecting the height and the density of BSs. The results reported here provide insights into the deployment of BSs in the UDNs.
Analyzing the Cost of Autogenous Cranioplasty Versus Custom-Made Patient-Specific Alloplastic Cranioplasty (2017)

Conclusions made from this paper will hopefully serve as guidance for allocation of hospital funding and resources at the Ministry of Health level.
Abstract 132: Cardiomyocyte Specific Conditional Overexpression Of Stromal Cell Derived Factor 1 Facilitates Cardiac Regeneration After Permanent Coronary Artery Ligation In Mice. (2014)

Background: Interruption of cardiac stromal cell derived factor 1 (SDF1)-CXCR4 axis by chronic AMD3100 administration increased myocardial injury after permanent coronary artery ligation demonstrating the important role of this chemokine in cardiac regeneration. Hypothesis: Cardiomyocyte specific conditional overexpression of SDF1 prevents heart failure after permanent coronary ligation and facilitates cardiac regeneration. Methods and Results: Tetracycline-controlled, αMyHC promoter directed overexpression of cardiac SDF1, resulted in a significant increase of SDF1 expression (SDF1: 8.1 ng/mg protein) compared to littermate WT mice (0.02 ng/mg protein) four weeks after doxycycline withdraw. SDF1 overexpression increased AKT and casein kinase 1 levels in the heart. Although there was no difference in cardiac function and scar size 1 week after infarction, SDF1 overexpression improved left ventricular (LV) ejection fraction (SDF1 [n=13]: 47±5% [mean±SEM] vs. WT [n=15]: 29±4%, p&lt;0.05) decreased end-diastolic volume (78±10 vs. 158±30, p&lt;0.05) and reduced infarct size measured by trichrome staining (13±3% vs. 23±3% of LV wall, p&lt;0.05) 4 weeks after permanent ligation. Bromodeoxyuridine (BrdU) staining revealed increased regeneration indicated by a 5-fold increase in BrdU + cardiomyocyte (CM) nuclei in the borderzone of the infarct (22±3% vs. 5±1% CM nuclei, p&lt;0.01). Increased proliferation in SDF1 mice was confirmed by a higher number of KI67 + cells compared to WT mice. Cardiomyocyte cross sectional area in the border zone was significantly reduced in SDF1 mice (365±13 μm 2 vs. 434±10 μm 2 , p&lt;0.001) while capillary density was unchanged (2348±151/ mm 2 vs. 2498±153/ mm 2 ) compared to WT mice. Conclusion: This study demonstrates for the first time that cardiac specific overexpression of SDF1 increases myocardial regeneration and improves LV function 4 weeks after permanent coronary ligation.
&lt;title&gt;Varrier autostereographic display&lt;/title&gt; (2001)

The goal of this research is to develop a head-tracked, stern virtual reality system utilizing plasma or LCD panels. This paper describes a head-tracked barrier auto-stereographic method that is optimized for real-time interactive virtual reality systems. In this method, virtual barrier screen is created simulating the physical barrier screen, and placed in the virtual world in front of the projection plane. An off- axis perspective projection of this barrier screen, combined with the rest of the virtual world, is projected from at least two viewpoints corresponding to the eye positions of the head- tracked viewer. During the rendering process, the simulated barrier screen effectively casts shadows on the projection plane. Since the different projection points cast shadows at different angles, the different viewpoints are spatially separated on the projection plane. These spatially separated images are projected into the viewer's space at different angles by the physical barrier screen. The flexibility of this computational process allows more complicated barrier screens than the parallel opaque lines typically used in barrier strip auto-stereography. In addition this method supports the focusing and steering of images for a user's given viewpoint, and allows for very wide angles of view. This method can produce an effective panel-based auto-stereo virtual reality system.
Central dicyanomethylene-substituted unsymmetrical squaraines and their application in organic solar cells (2018)

Introduction of <bold>diCN</bold>-substitution can lower the HOMO and improve the miscibility between <bold>diCN-USQ</bold> and PC<sub>71</sub>BM, leading to higher PCE.
Normative quantitative relaxation atlases for characterization of cortical regions using magnetic resonance fingerprinting (2022)

Quantitative magnetic resonance (MR) has been used to study cyto- and myelo-architecture of the human brain non-invasively. However, analyzing brain cortex using high-resolution quantitative MR acquisition can be challenging to perform using 3T clinical scanners. MR fingerprinting (MRF) is a highly efficient and clinically feasible quantitative MR technique that simultaneously provides T1 and T2 relaxation maps. Using 3D MRF from 40 healthy subjects (mean age = 25.6 ± 4.3 years) scanned on 3T magnetic resonance imaging, we generated whole-brain gyral-based normative MR relaxation atlases and investigated cortical-region-based T1 and T2 variations. Gender and age dependency of T1 and T2 variations were additionally analyzed. The coefficient of variation of T1 and T2 for each cortical-region was 3.5% and 7.3%, respectively, supporting low variability of MRF measurements across subjects. Significant differences in T1 and T2 were identified among 34 brain regions (P < 0.001), lower in the precentral, postcentral, paracentral lobule, transverse temporal, lateral occipital, and cingulate areas, which contain sensorimotor, auditory, visual, and limbic functions. Significant correlations were identified between age and T1 and T2 values. This study established whole-brain MRF T1 and T2 atlases of healthy subjects using a clinical 3T scanner, which can provide a quantitative and region-specific baseline for future brain studies and pathology detection.
Application of DNA‐binding polymers for preparation of DNA for analysis by matrix‐assisted laser desorption/ionization mass spectrometry (2001)

The susceptibility of matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) to the presence of salts in a sample, especially salts of alkali metals, requires careful and often tedious desalting procedures which complicate and slow the throughput of MS-based methods. A novel approach to sample preparation was developed based on the extraction of DNA out of solution onto a solid surface with an attached DNA-binding polymer, such as polyethyleneimine or polyvinylpyrrolidone. The observed binding is strong enough to sustain washing, and, as a result, desalting and concentration can be performed in a single fast step. After DNA has been immobilized on the surface and supernatant solution removed, subsequent addition of MALDI matrix releases material from the surface, which co-crystallizes with matrix. The mass spectrometric analysis is then performed directly from this support. Analysis of oligonucleotides and three-fold multiplexed SNP typing reactions performed by this method shows improved sensitivity and excellent resolution for various DNA fragments, together with high tolerance to various buffer components, such as alkali metals and surfactants. Simplicity and speed make it attractive for high-throughput sample preparation and analysis of oligonucleotide mixtures by MALDI-MS.
Regulation of Metformin Response by Breast Cancer Associated Gene 2 (2013)

Adenosine monophosphate-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis, has emerged as a promising molecular target in the prevention of breast cancer. Clinical trials using the United States Food and Drug Administration (FDA)-approved, AMPK-activating, antidiabetic drug metformin are promising in this regard, but the question of why metformin is protective for some women but not others still remains. Breast cancer associated gene 2 (BCA2/Rabring7/RNF115), a novel Really Interesting New Gene (RING) finger ubiquitin E3 ligase, is overexpressed in >50% of breast tumors. Herein, we report that BCA2 is an endogenous inhibitor of AMPK activation in breast cancer cells and that BCA2 inhibition increases the efficacy of metformin. BCA2 overexpression inhibited both basal and inducible Thr172 phosphorylation/activation of AMPKα1, while BCA2-specific small interfering RNA (siRNA) enhanced phosphorylated AMPKα1 (pAMPKα1). The AMPK-suppressive function of BCA2 requires its E3 ligase-specific RING domain, suggesting that BCA2 targets some protein controlling (de)phosphorylation of AMPKα1 for degradation. Activation of AMPK by metformin triggered a growth inhibitory signal but also increased BCA2 protein levels, which correlated with AKT activation and could be curbed by an AMPK inhibitor, suggesting a potential feedback mechanism from pAMPKα1 to pAkt to BCA2. Finally, BCA2 siRNA, or inhibition of its upstream stabilizing kinase AKT, increased the growth inhibitory effect of metformin in multiple breast cancer cell lines, supporting the conclusion that BCA2 weakens metformin's efficacy. Our data suggest that metformin in combination with a BCA2 inhibitor may be a more effective breast cancer treatment strategy than metformin alone.
16-Hydroxylation of Iridal (Triterpenoid from<i>Iris</i>Species) Mediated by Cytochrome P-450 (1995)

Abstract Incubation of a monocyclic iridal (a triterpenoid from Iris species) with rat liver microsomes in the presence of NADPH led to the degradation of this substrate and to the generation of 16-hydroxy-iridal (isoiridogermanal). This reaction which is inhibited by carbon monoxide seems to be mediated by cytochrome P-450. This observation strongly suggests that this monoxygenase, which is also present in intracellular Iris membranes, could be involved in plant iridal biosynthesis pathways.
NF-κB determines between apoptosis and proliferation in hepatocytes during liver regeneration (2000)

Tumor necrosis factor (TNF)-alpha is a potent inducer of apoptotic cell death in various tissues, whereas the transcription factor nuclear factor (NF)-kappaB is essential to protect against TNF-alpha-induced apoptosis. Human hepatoma cell lines were used to investigate the effectiveness and specificity of the fungal metabolite gliotoxin in inhibiting TNF-alpha-induced NF-kappaB activation in transformed cells. Gliotoxin-TNF-alpha cotreatment induced massive apoptosis in these otherwise TNF-alpha-resistant cell lines. With the use of the mouse partial hepatectomy model, we were also able to demonstrate in vivo the capacity of gliotoxin to act as inhibitor of NF-kappaB activation. Bromodeoxyuridine staining of liver sections showed that the lack of NF-kappaB activation correlated with 80% reduction of DNA synthesis 48 h after hepatectomy compared with untreated controls. Additionally, animals treated with gliotoxin showed nuclear condensation and DNA laddering of hepatocytes indicative of apoptosis 24 h after hepatectomy. In summary, our results demonstrate that NF-kappaB is essential in defining the fate of liver cells in response to TNF-alpha in vivo and furthermore implicate gliotoxin as a potential new response modifier for TNF-alpha-based therapy.
Loratadine and Analogues: Discovery and Preliminary Structure–Activity Relationship of Inhibitors of the Amino Acid Transporter B<sup>0</sup>AT2 (2014)

B(0)AT2, encoded by the SLC6A15 gene, is a transporter for neutral amino acids that has recently been implicated in mood and metabolic disorders. It is predominantly expressed in the brain, but little is otherwise known about its function. To identify inhibitors for this transporter, we screened a library of 3133 different bioactive compounds. Loratadine, a clinically used histamine H1 receptor antagonist, was identified as a selective inhibitor of B(0)AT2 with an IC50 of 4 μM while being less active or inactive against several other members of the SLC6 family. Reversible inhibition of B(0)AT2 was confirmed by electrophysiology. A series of loratadine analogues were synthesized to gain insight into the structure-activity relationships. Our studies provide the first chemical tool for B(0)AT2.
Energy levels of lanthanide ions in a<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mi mathvariant="normal">Lu</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">Si</mml:mi><mml:mn>2</mml:mn></mml:msub><mml:msub><mml:mi mathvariant="normal">O</mml:mi><mml:mn>7</mml:mn></mml:msub></mml:mrow></mml:math>host (2005)

Emission and excitation spectra of single crystals of ${\mathrm{Lu}}_{2}{\mathrm{Si}}_{2}{\mathrm{O}}_{7}$ doped with ${\mathrm{Ce}}^{3+}$, ${\mathrm{Pr}}^{3+}$, ${\mathrm{Nd}}^{3+}$, ${\mathrm{Sm}}^{3+}$, ${\mathrm{Eu}}^{3+}$, ${\mathrm{Tb}}^{3+}$, and ${\mathrm{Yb}}^{3+}$ were measured in the VUV and UV ranges in order to locate the lanthanide energy levels relative to the valence and conduction bands of the matrix. Predictive energy level diagrams for divalent and trivalent lanthanides in ${\mathrm{Lu}}_{2}{\mathrm{Si}}_{2}{\mathrm{O}}_{7}$ were also constructed thanks to the knowledge of only three parameters. The observed energies of $4f\text{\penalty1000-\hskip0pt}5d$ transitions and charge transfer bands are in good agreement with predictions of the level schemes. Finally, as ${\mathrm{Lu}}_{2}{\mathrm{Si}}_{2}{\mathrm{O}}_{7}$: ${\mathrm{Ce}}^{3+}$ is an efficient scintillator material, these energy diagrams can also be used to go further in the scintillation mechanisms by identifying different traps observed in this scintillator.
Leakage and Cavity Pressures in an Interlocking Labyrinth Gas Seal: Measurements Versus Predictions (2019)

Gas labyrinth seals (LS) restrict secondary flows (leakage) in turbomachinery and their impact on the efficiency and rotordynamic stability of high-pressure compressors and steam turbines can hardly be overstated. Among seal types, the interlocking labyrinth seal (ILS), having teeth on both the rotor and the stator, is able to reduce leakage up to 30% compared to other LSs with either all teeth on the rotor (TOR) or all teeth on the stator. This paper introduces a revamped facility to test gas seals for their rotordynamic performance and presents measurements of the leakage and cavity pressures in a five teeth ILS. The seal with overall length/diameter L/D = 0.3 and small tip clearance Cr/D = 0.00133 is supplied with air at T = 298 K and increasing inlet pressure Pin = 0.3–1.3 MPa, while the exit pressure/inlet pressure ratio PR = Pout/Pin is set to range from 0.3 to 0.8. The rotor speed varies from null to 10 krpm (79 m/s max. surface speed). During the tests, instrumentation records the seal mass flow (m˙) and static pressure in each cavity. In parallel, a bulk-flow model (BFM) and a computational fluid dynamics (CFD) analysis predict the flow field and deliver the same performance characteristics, namely leakage and cavity pressures. Both measurements and predictions agree closely (within 5%) and demonstrate that the seal mass flow rate is independent of rotor speed. A modified flow factor Φ¯=m˙T/(PinD1−PR2) characterizes best the seal mass flow with a unique magnitude for all pressure conditions, Pin and PR.
Active Contours Propagation In A Medical Images Sequence With A Local Estimation (2002)

Publication in the conference proceedings of EUSIPCO, Toulouse, France, 2002