gebhart/patrepeval huggingface dataset:
Outside-in signaling in the chondrocyte. Nitric oxide disrupts fibronectin-induced assembly of a subplasmalemmal actin/rho A/focal adhesion kinase signaling complex. (1997)

Elevated levels of fibronectin (Fn) in articular cartilage have been linked to the progression of both rheumatoid and osteoarthritis. In this study, we examined intracellular events which follow ligation of Fn to its receptor, the integrin alpha5beta1. In addition, we examined the regulatory influence of nitric oxide on these events, since this free radical has been implicated in cartilage degradation. Exposure of chondrocytes to Fn-coated beads resulted in the circumferential clustering of the alpha5beta1 integrin receptor, which was accompanied by the subplasmalemmal assembly of a focal activation complex comprised of F-actin, the tyrosine kinase, focal adhesion kinase (FAK), the ras related G protein rho A, as well as tyrosine-phosphorylated proteins. Treatment with exogenous nitric oxide (NO) or catabolic cytokines which induce nitric oxide synthase blocked the assembly of F-actin, FAK, rho A and tyrosine-phosphorylated proteins while not affecting the total number of beads bound per cell nor the clustering of alpha5beta1 integrin. Use of a cGMP antagonist (Rp-8-Br cGMPS) or cGMP agonist (Sp-cGMPS) either abolished or mimicked the NO effect, respectively. Adherence of chondrocytes to fibronectin enhanced proteoglycan synthesis by twofold (vs. albumin). In addition, basic fibroblast growth factor (FGF) and insulin growth factor (IGF-1) induced proteoglycan synthesis in chondrocytes adherent to Fn but not albumin suggesting a costimulatory signal transduced by alpha5betal and the FGF receptor. Both constitutive and FGF stimulated proteoglycan synthesis were completely inhibited by nitric oxide. These data indicate that the ligation of alpha5beta1 in the chondrocyte induced the intracellular assembly of an activation complex comprised of the cytoplasmic tail of alpha5beta1 integrin, actin, and the signaling molecules rho A and FAK. We show that NO inhibits the assembly of the intracellular activation complex and the synthesis of proteoglycans, but has no effect on the extracellular aggregation of alpha5beta1 integrin. These observations provide a basis by which nitric oxide can interfere with chondrocyte functions by affecting chondrocyte-matrix interactions.
Dielectrophoresis-assisted plasmonic trapping of dielectric nanoparticles (2017)

A method for efficiently trapping nanoparticles using a dielectrophoresis (DEP)-assisted plasmonic trap is presented. The proposed method overcomes the range limitations of a conventional plasmonic trap by employing a long-range DEP force to draw a nanoparticle closer to the plasmonic trap. To create the plasmonic trap, a $\mathsf{C}$-shaped engraving is used as it can trap a nanoparticle in a very small volume near the surface. A nanopillar is selected as the electrode to generated the DEP force as its height allows the force to extend further away from the surface. Extensive numerical simulations are performed to evaluate the performance improvement of the proposed scheme over conventional plasmonic trapping methods. The simulations show that the proposed scheme increases the probability of a successful trapping event by a factor of approximately three.
Drag reduction by microbubble injection in a channel flow (2008)

La inyeccion de microburbujas en la capa limite turbulenta en el flujo dentro de un canal es investigada para entender el fenomeno de reduccion del arrastre. Resultados experimentales en un flujo totalmente desarrollado dentro de un canal cerrado fueron obtenidos utilizando la tecnica de Velocimetria por Imagenes de Particulas (PIV) para una sola fase y dos fases. Ambos casos son comparados para analizar los efectos de la presencia de las microburbujas dentro de la capa limite. Especificamente las modificaciones en la vorticidad, vortices y tasa de deformacion. Esta ultima directamente relacionada con la disipacion de energia en flujo turbulento. Estos resultados son significativos y pueden ayudar a entender de manera mas precisa el mecanismo fisico de la reduccion del arrastre por inyeccion de microburbujas.
Insights into docking and scoring neuronal α4β2 nicotinic receptor agonists using molecular dynamics simulations and QM/MM calculations (2009)

Abstract A combined quantum mechanical (QM)‐polarized docking and molecular dynamics approach to study the binding mode and to predict the binding affinity of ligands acting at the α4β2‐nAChR is presented. The results obtained in this study indicate that the quantum mechanical/molecular mechanics docking protocol well describes the charge‐driven interactions occurring in the binding of nicotinic agonists, and it is able to represent the polarization effects on the ligand exerted by the surrounding atoms of the receptor at the binding site. This makes it possible to properly score agonists of α4β2‐nAChR and to reproduce the experimental binding affinity data with good accuracy, within a mean error of 2.2 kcal/mol. Moreover, applying the QM‐polarized docking to an ensemble of nAChR conformations obtained from MD simulations enabled us to accurately capture nAChR‐ligand induced‐fit effects. © 2009 Wiley Periodicals, Inc. J Comput Chem, 2009
Arguments Supporting the Use of Calcium Antagonists in Idiopathic Dilated Cardiomyopathy (1990)

There is increasing evidence that sarcolemmal disorders in idiopathic dilated cardiomyopathy (IDC), due either to viral infection, catecholamine excess, ethanol intoxication, microcirculatory disorders, or autoimmune responses, induce enhanced Ca2+ inflow. This may lead to mitochondrial Ca2+ accumulation and activation of phospholipase and proteases, resulting in left ventricular dysfunction. The acute beneficial hemodynamic response to diltiazem in IDC patients, in comparison to other calcium blockers, enabled us to perform an open trial investigating the effects of chronic diltiazem (60-90 mg t.i.d.) in patients with IDC. The results of this trial suggested that adjunctive diltiazem in IDC had beneficial effects on mortality, hemodynamics, and symptoms. Thus a multicenter, double-blind, placebo-controlled trial was initiated.
Comprehensive experimental performance study on a small-capacity transcritical R744 vapour-compression refrigeration unit equipped with an innovative ejector (2023)

Ejector-equipped transcritical R744 condensing units are believed to lead to a low-to-zero commercial refrigeration sector. In order to overcome the persisting barrier to their wider adoption represented by the lack of an affordable ejector control technique, the novel pulse-width modulation (PWM) ejector, being low cost, simple and invulnerable to clogging was recently implemented. However, additional experimental evaluations are needed. Therefore, in this experimental work the performance of two PWM ejector-equipped transcritical R744 condensing units, i.e. with and without overfed evaporator, was carried out. The experimental assessment was implemented at the medium temperature (MT) of about -5°C, heat sink temperatures from 30°C to 40°C and compressor speeds from 40 Hz to 60 Hz. The outcomes obtained revealed that the PWM ejector can effectively control the high pressure in transcritical operating conditions, regardless of the selected heat sink temperature and compressor speed. In addition, at the same cooling capacity, the PWM ejector-equipped R744 system was found to permit energy savings between 7.0 % and 11.1 % without overfed evaporator and between 11.5 % and 16.3 % with overfed evaporator compared to the standard R744 unit (i.e. with vapour by-pass valve and without ejector), respectively. Finally, higher values of coefficient of performance (COP) were found to be offered by the PWM ejector compared with its today's available competitors.
Chemical tracers in archaeological and natural gold: Aliseda Tartessos treasure and new discovered nuggets (SW Spain) (2005)

The gold outcrops employed by the ancient kingdom of Tartessos, settled in the SW of the Iberian Peninsula from ca. 10th to the 6th century BC, for the Aliseda treasure manufacture, has been discovered. This paper reports on the finding of collected gold nuggets, more than 80 units up to 218 g, in an ancient mining area located in Casas de Pedro (Extremadura, SW of Spain). The comparative physical-chemical analyses between these gold nuggets picked at present and the archaeological gold collected in 1920, have been performed by microscopy, X-ray diffraction (XRD), thermoluminescence (TL), X-ray photoelectron spectrometry (XPS) and electron microprobe analyses (EMPA). Pieces of Aliseda treasure and the picked gold nuggets show a highly homogeneous chemical composition of trace elements namely: As 0.01%, S 0.02%, Bi 0.35%, Fe 0.016%, Ag 0.8%, Sb 0.05% and Te 0.04%. The small difference between both gold samples is only of 0.2% extra copper in Aliseda due to an anthropogenic addition of a silver-copper mixture during a second firing of the jewel to weld ornamental spheres.
Versatile Fabrication of Distorted Cubic Mesoporous Silica Film Using CTAB Together with a Hydrophobic Organic Additive (2006)

We have succeeded in the fabrication of distorted cubic R-3m mesoporous silica film with 3D open mesostructure providing high pore accessibility from the surface-air interface of the film. The film fabrication involves a unique approach of adding 1,3,5- triisopropylbenzene (TIPB) to the silica/cetyltrimethylammoniumbromide (CTAB) coating sol during its preparation. The addition of TIPB induces the formation of spheroid micelles, promoting R-3m mesostructure in the film. This phase does not exist in the corresponding binary phase diagram of CTAB surfactant.
Hydrogen Storage in Pristine and d10-Block Metal-Anchored Activated Carbon Made from Local Wastes (2015)

Activated carbon has been synthesized from local palm shell, cardboard and plastics municipal waste in the Kingdom of Saudi Arabia. It exhibits a surface area of 930 m2/g and total pore volume of 0.42 cm3/g. This pristine activated carbon has been further anchored with nickel, palladium and platinum metal particles by ultrasound-assisted impregnation. Deposition of nanosized Pt particles as small as 3 nm has been achieved, while for Ni and Pd their size reaches 100 nm. The solid-gas hydrogenation properties of the pristine and metal-anchored activated carbon have been determined. The pristine material exhibits a reversible hydrogen storage capacity of 2.3 wt% at 77 K and 3 MPa which is higher than for the doped ones. In these materials, the spillover effect due to metal doping is of minor importance in enhancing the hydrogen uptake compared with the counter-effect of the additional mass of the metal particles and pore blocking on the carbon surface.
Satellite Antennas (2016)

Abstract Satellite antenna systems for both the space and user segments are described in terms of their system requirements, technology, development issues, and test methodologies. Today's antenna systems have greatly contributed to satellite system capabilities and significant opportunities continue to provide further challenges to creatively evolve even more capable and affordable system capabilities. These antenna technology and development issues for different satellite system capabilities and their associated evaluation issues are described to foster till further evolution of satellite antennas.
MAP4K4 regulates forces at cell–cell and cell–matrix adhesions to promote collective cell migration (2023)

Collective cell migration is not only important for development and tissue homeostasis but can also promote cancer metastasis. To migrate collectively, cells need to coordinate cellular extensions and retractions, adhesion sites dynamics, and forces generation and transmission. Nevertheless, the regulatory mechanisms coordinating these processes remain elusive. Using A431 carcinoma cells, we identify the kinase MAP4K4 as a central regulator of collective migration. We show that MAP4K4 inactivation blocks the migration of clusters, whereas its overexpression decreases cluster cohesion. MAP4K4 regulates protrusion and retraction dynamics, remodels the actomyosin cytoskeleton, and controls the stability of both cell-cell and cell-substrate adhesion. MAP4K4 promotes focal adhesion disassembly through the phosphorylation of the actin and plasma membrane crosslinker moesin but disassembles adherens junctions through a moesin-independent mechanism. By analyzing traction and intercellular forces, we found that MAP4K4 loss of function leads to a tensional disequilibrium throughout the cell cluster, increasing the traction forces and the tension loading at the cell-cell adhesions. Together, our results indicate that MAP4K4 activity is a key regulator of biomechanical forces at adhesion sites, promoting collective migration.
Corrigendum: Aryl(triethyl)silanes for Biaryl and Teraryl Synthesis by Copper(II)‐Catalyzed Cross‐Coupling Reaction (2017)

In this Communication, Table (
From α‐1,2‐Anhydrosugars to C‐Glycosides: The Influence of Lewis Acids and Nucleophiles on the Stereochemistry. (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Isolation of antimalarial active compound derived from Indonesian soil actinomycete Streptomyces sp. BioMCC-a.T.3335 (2023)

An Indonesia soil actinomycete, Streptomyces sp. BioMCC-a.T.3335 was cultured to find compounds that showing inhibitory activity against Plasmodium falciparum cell proliferation. The properties of active compounds in the extract were examined by conducting a preliminary extraction test (PET). Extraction and purification method of active compounds was developed based on PET result. We identified two active compounds, cosmomycin A (1) and B (2), from the extract as active compounds. Cosmomycin A inhibited the proliferation of P. falciparum 3D7 cell in vitro (IC50=2.8 nM). To our best knowledge, 1 and 2 have never been reported as anti-malarial agents before.
Diastereo- and Enantioselective Synthesis of trans-2-Amino-Cycloalkane-1-Carboxylic Acids via Intramolecular Tandem Michael-Addition/α-Alkylation Using TMS-SAMP as Chiral Equivalent of Ammonia (1995)

trans-2-amino cyclopentane-, cyclohexane- and cycloheptane-1-carboxylic acids of high diastereo- and enantiomeric purity (de ≥ 96-98%, ee ≥ 98%) are prepared utilizing the stereoselective conjugate addition of lithiated (S)-(-)-2-methoxymethyl-1-trimethylsilylamino-pyrrolidine (TMS-SAMP) to ω-halide substituted α,β-unsaturated enoates followed by subsequent ring closure of the intermediate ester enolate (MIRC-reaction). The auxiliary is removed by reductive N-N bond cleavage.
VENUS: A System for Novelty Detection in Video Streams with Learning. (2004)

Novelty detection in video is a rapidly developing application domain within computer vision. The motivation behind this paper is a learning based framework for detecting novelty within video. Since, humans have a general understanding about their environment and possess a sense of distinction between what is normal and abnormal about the environment based on our prior experience; any aspect of the scene that does not fit into this definition of normalcy tends to be labeled as a novel event. In this paper, we propose a computational learning based framework for novelty detection and provide the experimental evidence to describe the results obtained by this framework. To begin with the framework extracts low-level features from scenes, based on the focus of attention theory and then combines unsupervised learning techniques such as clustering with habituation theory to emulate the cognitive aspect of learning.
Mineralized Tissues in Oral and Craniofacial Science (2012)

Mineralized tissues in oral and craniofacial science : , Mineralized tissues in oral and craniofacial science : , کتابخانه دیجیتال جندی شاپور اهواز
[Dislocation fractures of the Chopart and Lisfranc joint]. (1989)

Dislocation fractures of Chopart's and Lisfranc's (mediotarsal) articulation result from the effects of impact and, because there are many possible complications, require a high level of experience on the part of the treating traumatologist. To avoid residual joint incongruities and intra-articular osteochondral fragments with subsequent early arthrosis and the corresponding complaints, the indications for open reduction and functionally stable osteosynthesis should be broad. The osteosynthesis can be achieved by transfixation with adjustable screws and 3.5 or 2.7 mm screws suitable for small fragments. This permits postoperative treatment to be carried out with a walking cast rather than a full plaster cast. In emergency patients with multiple injuries, dislocation fractures in the tarsal region require immediate and definitive treatment in order to avoid grave consequences and pain severe enough to influence the quality of life.
가스 크로마토그래피를 부착한 표면탄성파 가스 센서 (2007)

This paper presents characteristics of surface acoustic wave (SAW) gas sensor for detecting volatile gases such as acetone, methanol, and ethanol by measuring phase shift of output signal. A delay-line by combining with a center frequency of 200 MHz was fabricated on S-T Quartz substrates. Using gas...
An open-label phase II study of sorafenib and dacarbazine as first-line therapy in patients with advanced melanoma (2007)

8529 Background: Sorafenib (SOR) exerts anti-tumor and anti-angiogenic effects via inhibition of VEGFR-1,-2,-3, PDGFR-a, -β and Raf. In a phase I, study SOR + dacarbazine (DTIC) as first-line therapy for advanced melanoma patients (pts) was well-tolerated and had activity. Methods: In this multicenter, phase II, open-label, uncontrolled, 2-stage study, eligibility criteria included: measurable disease by RECIST, ECOG performance status 0 or 1, no prior chemotherapy. Prior immunotherapy was allowed. Planned sample size was 82 pts based on a Simon 2-stage optimal design. Pts were treated with oral SOR 400 mg bid daily combined with repeated 21-day cycles of iv DTIC 1,000 mg/m 2 given on day 1 of each cycle until occurrence of progressive disease or intolerable toxicity. The primary endpoint was overall tumor response rate using RECIST. Secondary endpoints included progression-free survival (PFS), overall survival (OS), safety and toxicity. Results: 30 and 53 pts were treated in Stages I and II, respectively. Baseline characteristics were as follows: median age 56 yrs; 60% male, 34% ECOG 1, 80% AJCC Stage IV M1c; 31% elevated LDH. Eight (10%) pts had partial responses, 34 (41%) had stable disease, 32 (39%) had progressive disease and 9 (11%) were not evaluable. The median PFS was 14 wks (95% CI 12, 19; 28% censored). PFS rates at 3 &amp; 6 mos were 56% (45%, 67%; 13% censored) and 33% (22%, 45%; 24% censored), respectively. Median OS was 41 wks (28, 59, 63% censored). Grade 3/4 drug-related adverse events included: neutrophils 33%, platelets 22%, hand-foot skin reaction 8%, fatigue 7% and abdominal pain 6%. 1 patient had febrile neutropenia. To correlate treatment response with mutational status, melanoma samples from 20 pts were analyzed for mutations in B-RAF (exon 15) and PI3Kinase (exons 9 &amp; 20). 3 of 20 samples had V600E mutations in B- RAF; no PI3Kinase alterations were detected. Conclusions: Addition of SOR to DTIC was well-tolerated and resulted in encouraging PFS and OS rates in this poor prognostic cohort of patients. The data are promising as compared with published results of DTIC alone in metastatic melanoma (RR 7.5%, PFS 6 wks; Bedikian et al. 2006). A recently completed randomized Phase II trial will provide additional information on the efficacy of this combination regimen. [Table: see text]
Head-Worn Markerless Augmented Reality Inside A Moving Vehicle (2022)

This paper describes a system that provides general head-worn outdoor augmented reality (AR) capability for the user inside a moving vehicle. Our system follows the concept of combining pose estimation from both vehicle navigation system and wearable sensors to address the failure of commercial AR devices inside a moving vehicle. We continuously match natural visual features from the camera against a prebuilt database of interior vehicle scenes. To improve the robustness in a moving vehicle with other passengers, a human detection module is adapted to filter out people from the camera scene. Experiments demonstrate the effectiveness of the proposed solution.
Development of Fault Point Locating System for Underground Transmission Lines using Optical Fiber Current Sensors (2008)

Fault point locating systems based on surge current detection have recently been used for fast recovery of underground transmission line from the fault. Electromagnetic induction type sensors have mainly been used for detection of the surge current. However they are susceptible to electromagnetic noise which causes unstable system operation. To solve this problem, Tokyo Electric Power Co., Toko Electric Corporation and Fujikura Ltd., by a joint research, have developed a new system that applies optical fiber current sensors.
Carbon monoxide-releasing molecules reverse leptin resistance induced by endoplasmic reticulum stress (2013)

Leptin, a circulating hormone, regulates food intake and body weight. While leptin resistance represents a major cause of obesity, the underlying mechanisms remain unclear. Endoplasmic reticulum (ER) stress can contribute to leptin resistance. Carbon monoxide (CO), a gaseous molecule, exerts antiapoptotic and anti-inflammatory effects in animal models of tissue injury. We hypothesized that CO could inhibit leptin resistance during ER stress. Thapsigargin or tunicamycin was used to induce ER stress in human cells expressing the leptin receptor. These agents markedly inhibited leptin-induced STAT3 phosphorylation, confirming that ER stress induces leptin resistance. The CO-releasing molecule CORM-2 blocked the ER stress-dependent inhibition of leptin-induced STAT3 phosphorylation. CORM-2 treatment induced the phosphorylation of protein kinase R-like endoplasmic reticulum kinase (PERK), and eukaryotic translation initiation factor-2α and enhanced PERK phosphorylation during ER stress. Furthermore, CORM-2 inhibited X-box binding protein-1 expression, activating transcription factor-6 cleavage, and inositol-requiring enzyme (IRE)1α phosphorylation induced by ER stress. IRE1α knockdown rescued leptin resistance, whereas PERK knockdown blocked CO-dependent regulation of IRE1α. In vivo, CO inhalation normalized body weight in animals fed high-fat diets. Furthermore, CO modulated ER stress pathways and rescued leptin resistance in vivo. In conclusion, the pathological mechanism of leptin resistance may be ameliorated by the pharmacological application of CO.
Robotic Emulation of Candidate Prosthetic Foot Designs May Enable Efficient, Evidence-Based, and Individualized Prescriptions (2021)

Today, emulator technology is being used to accelerate research and development of novel prosthetic and orthotic devices. In the future, after further refinement and validation, this technology could benefit clinical practice by providing a means for rapid test-driving and optimal selection of clinically available prosthetic feet.
Recent Clinical Advances in Lung Cancer Management (2014)

Progress in lung cancer therapy has been slow but steady and has accelerated due to improvements in scientific basis for the disease and to technologic advances in diagnosis and therapy. The elusive goal of reduced mortality rates can be achieved in the next 50 years through continued interdisciplinary research efforts.
Author response: Prolonged T-cell activation and long COVID symptoms independently associate with severe COVID-19 at 3 months (2023)

Prolonged CD4+ and CD8+ T-cell activation and long COVID symptoms at 3 months post hospitlization independently associate with severe COVID-19, and ongoing T-cell activation does not affect the generation and maintenance of memory T-cell and antibody responses to SARS-CoV-2.
Silicon carbidonitride based phosphors and lighting devices using the same (2023)

Disclosed herein are novel families of silicon carbidonitride phosphor compositions. In certain embodiments, optimal ranges of carbon content have been identified which provide excellent luminescence and thermal stability characteristics.