gebhart/patrepeval huggingface dataset:
Gaussian Process for Propagation Modeling and Proximity Reports Based Indoor Positioning (2016)

The commercial interest in proximity services is increasing. Application examples include location- based information and advertisements, logistics, social networking, file sharing, etc. In this paper, we consider network-based positioning based on times series of proximity reports from a mobile device, either only a proximity indicator, or a vector of RSS from observed nodes. Such positioning corresponds to a latent and nonlinear observation model. To address these problems, we combine two powerful tools, namely particle filtering and Gaussian process regression (GPR) for radio signal propagation modeling. The latter also provides some insights into the spatial correlation of the radio propagation in the considered area. Radio propagation modeling and positioning performance are evaluated in a typical office area with Bluetooth-Low-Energy (BLE) beacons deployed for proximity detection and reports. Results show that the positioning accuracy can be improved by using GPR.
Prophylactic heparin and risk of orotracheal intubation or death in patients with mild or moderate COVID-19 pneumonia (2021)

Abstract Prophylactic low molecular weight heparin (pLMWH) is currently recommended in COVID-19 to reduce the risk of coagulopathy. The aim of this study was to evaluate whether the antinflammatory effects of pLMWH could translate in lower rate of clinical progression in patients with COVID-19 pneumonia. Patients admitted to a COVID-hospital in Rome with SARS-CoV-2 infection and mild/moderate pneumonia were retrospectively evaluated. The primary endpoint was the time from hospital admission to orotracheal intubation/death (OTI/death). A total of 449 patients were included: 39% female, median age 63 (IQR, 50–77) years. The estimated probability of OTI/death for patients receiving pLMWH was: 9.5% (95% CI 3.2–26.4) by day 20 in those not receiving pLMWH vs. 10.4% (6.7–15.9) in those exposed to pLMWH; p-value = 0.144. This risk associated with the use of pLMWH appeared to vary by PaO 2 /FiO 2 ratio: aHR 1.40 (95% CI 0.51–3.79) for patients with an admission PaO 2 /FiO 2 ≤ 300 mmHg and 0.27 (0.03–2.18) for those with PaO 2 /FiO 2 &gt; 300 mmHg; p-value at interaction test 0.16. pLMWH does not seem to reduce the risk of OTI/death mild/moderate COVID-19 pneumonia, especially when respiratory function had already significantly deteriorated. Data from clinical trials comparing the effect of prophylactic vs. therapeutic dosage of LMWH at various stages of COVID-19 disease are needed.
<i>Gaia</i> Early Data Release 3 (2020)

Context. This work is part of the Gaia Data Processing and Analysis Consortium papers published with the Gaia Early Data Release 3 (EDR3). It is one of the demonstration papers aiming to highlight the improvements and quality of the newly published data by applying them to a scientific case. Aims. We use the Gaia EDR3 data to study the structure and kinematics of the Magellanic Clouds. The large distance to the Clouds is a challenge for the Gaia astrometry. The Clouds lie at the very limits of the usability of the Gaia data, which makes the Clouds an excellent case study for evaluating the quality and properties of the Gaia data. Methods. The basis of our work are two samples selected to provide a representation as clean as possible of the stars of the Large Magellanic Cloud (LMC) and the Small Magellanic Cloud (SMC). The selection used criteria based on position, parallax, and proper motions to remove foreground contamination from the Milky Way, and allowed the separation of the stars of both Clouds. From these two samples we defined a series of subsamples based on cuts in the colour-magnitude diagram; these subsamples were used to select stars in a common evolutionary phase and can also be used as approximate proxies of a selection by age. Results. We compared the Gaia Data Release 2 and Gaia EDR3 performances in the study of the Magellanic Clouds and show the clear improvements in precision and accuracy in the new release. We also show that the systematics still present in the data make the determination of the 3D geometry of the LMC a difficult endeavour; this is at the very limit of the usefulness of the Gaia EDR3 astrometry, but it may become feasible with the use of additional external data. We derive radial and tangential velocity maps and global profiles for the LMC for the several subsamples we defined. To our knowledge, this is the first time that the two planar components of the ordered and random motions are derived for multiple stellar evolutionary phases in a galactic disc outside the Milky Way, showing the differences between younger and older phases. We also analyse the spatial structure and motions in the central region, the bar, and the disc, providing new insightsinto features and kinematics. Finally, we show that the Gaia EDR3 data allows clearly resolving the Magellanic Bridge, and we trace the density and velocity flow of the stars from the SMC towards the LMC not only globally, but also separately for young and evolved populations. This allows us to confirm an evolved population in the Bridge that is slightly shift from the younger population. Additionally, we were able to study the outskirts of both Magellanic Clouds, in which we detected some well-known features and indications of new ones.
Integrin α3β1–dependent β-catenin phosphorylation links epithelial Smad signaling to cell contacts (2009)

Injury-initiated epithelial to mesenchymal transition (EMT) depends on contextual signals from the extracellular matrix, suggesting a role for integrin signaling. Primary epithelial cells deficient in their prominent laminin receptor, alpha3beta1, were found to have a markedly blunted EMT response to TGF-beta1. A mechanism for this defect was explored in alpha3-null cells reconstituted with wild-type (wt) alpha3 or point mutants unable to engage laminin 5 (G163A) or epithelial cadherin (E-cadherin; H245A). After TGF-beta1 stimulation, wt epithelial cells but not cells expressing the H245A mutant internalize complexes of E-cadherin and TGF-beta1 receptors, generate phospho-Smad2 (p-Smad2)-pY654-beta-catenin complexes, and up-regulate mesenchymal target genes. Although Smad2 phosphorylation is normal, p-Smad2-pY654-beta-catenin complexes do not form in the absence of alpha3 or when alpha3beta1 is mainly engaged on laminin 5 or E-cadherin in adherens junctions, leading to attenuated EMT. These findings demonstrate that alpha3beta1 coordinates cross talk between beta-catenin and Smad signaling pathways as a function of extracellular contact cues and thereby regulates responses to TGF-beta1 activation.
Simulation-based Planning of Production Capacity through Integrative Roadmapping in the Wind Turbine Industry (2015)

The development and effective implementation of a production strategy requires an interdisciplinary planning of products, manufacturing technologies and factory concepts. The integrative roadmapping allows the merging of these planning areas and takes into account the occurring interactions. This article shows the concept and software implementation of the integrative roadmapping for a systematic creation of roadmaps using the example of rotor blade production in the wind turbine industry. To reduce planning time and cost the workflow in the rotor blade production has been transferred to a material flow simulation to estimate the mutual impact on the production capacity by product, technology and factory within the planning phase.
Influence of dielectric barrier discharges on low Mach number shock waves at low to medium pressures (2005)

For shock wave propagation in nonequilibrium plasmas, it has been shown that when the electron Debye length exceeds the shock wave discontinuity dimension, strong double layers are generated, propagating with the shock wave. Strong double layer formation leads to the enhancement of the local excitation, ionization, and local neutral gas heating which increases the shock wave velocity. It is shown that dielectric barrier discharges (DBD) in pure N2 also increase the shock wave velocity and broaden the shock wave. The DBD is considerably more energy efficient in producing these effects compared to a dc glow discharge and can operate over a wide pressure range. It is shown that these effects are also operative in the pure N2 discharge afterglow, allowing a wide range of pulse repetition frequencies.
The Influence of Structure on Dissolution Inhibition for Novolac-Based Photoresists: Adaption of the Probabilistic Approach (1998)

In this paper, several theories describing the molecular-level interactions between novolac and the dissolution inhibitors are discussed. Evidence is provided that small changes in the hydrogen bonding interactions between the dissolution inhibitor and the novolac resin can create large differences in resist dissolution rates. The strength of this interaction is shown to depend on the basicity of the hydrogen bond acceptor site in the inhibitor. This correlation is based on a linear free energy relationship in a series of benzophenones with different substituents. Also, the dissolution inhibition efficiencies of a series of sulfonyl esters are shown to be better than structurally similar carbonyl esters. These experiments reveal a set of criteria for the rational design of dissolution inhibitors.
Efficacy and safety of nivolumab in Japanese patients with uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma: Multicenter, open‐label phase 2 trial (2019)

Nivolumab is a human monoclonal antibody against the immune checkpoint receptor programmed death-1, inhibiting binding to programmed death-ligand 1 or 2 (PD-L1 or PD-L2). This phase 2 study evaluated the efficacy and safety of nivolumab in patients with advanced/recurrent uterine cervical cancer, uterine corpus cancer, or soft tissue sarcoma (STS). Patients received nivolumab 240 mg at 2-week intervals. Primary endpoint was objective response rate; secondary endpoints included overall survival, progression-free survival, and safety. PD-L1 expression and microsatellite-instability (MSI) status were analyzed as potential efficacy biomarkers. Objective response rate was 25%, 23%, and 0% in patients with cervical cancer (n = 20), corpus cancer (n = 22), and STS (n = 21), respectively. The lower 80% confidence intervals of objective response rates in patients with cervical or corpus cancer exceeded the threshold rate (5%); the primary endpoint was met in cervical and corpus cancer, but not in STS. Median progression-free survival was 5.6, 3.4, and 1.4 months, and 6-month overall survival was 84%, 73%, and 86% in cervical cancer, corpus cancer, and STS, respectively. The objective response rate was higher in patients with cervical cancer with PD-L1-positive (n = 5/15; 33%) versus PD-L1-negative (n = 0/5; 0%) tumors. The two patients with corpus cancer classified as MSI-high responded; the six patients classified as microsatellite stable did not respond. Overall, nivolumab showed acceptable toxicity in all cohorts, with evidence of clinical activity in uterine cervical or corpus cancer, but not in STS. PD-L1 expression in cervical cancer and MSI-high in corpus cancer may predict clinical activity of nivolumab in these cancers.
The alignment distance on Spaces of Linear Dynamical Systems (2013)

We introduce a family of group action induced distances on spaces of Linear Dynamical Systems (LDSs) of fixed size and order. The distance between two LDSs is computed by finding the change of basis that best aligns the state-space realizations of the two LDSs, hence the name alignment distance. This distance can be computed efficiently, hence it is particularly suitable for applications in modern dynamic data analysis (e.g., video sequence classification and clustering), where a large number of high-dimensional LDSs may need to be compared. Based on the alignment distance, we also define a notion of average between LDSs of the same size and order with the property that the order and in some cases stability are naturally preserved. Various extensions to the basic notion of alignment distance are also proposed.
Vibrational Properties and Specific Heat of Ultrananocrystalline Diamond: Molecular Dynamics Simulations (2011)

Ultrananocrystalline diamond (UNCD) has become a widely studied material with many potential applications in nanotechnology due to its attractive thermal, mechanical, and chemical properties. While several experimental techniques including Raman spectroscopy have been used to characterize the structural and dynamical properties of UNCD, a detailed understanding of the vibrational dynamics at the atomic level is still lacking. Here, using molecular dynamics simulations, we investigate the structure and dynamics of UNCD to elucidate the role of the grain boundary and interior atoms in detail. Our study considers a UNCD model of 4 nm average grain size, constructed using the Voronoi method. We analyzed the local structure and vibrational properties of the grain boundary and interior atoms. Further, we computed the specific heat of UNCD as a function of temperature from the vibrational spectra. We find that the specific heat of UNCD shows enhancements of approximately 20% over that of single-crystal diamond at 300 K. The excess specific heat in UNCD in comparison to single-crystal diamond is found to be maximum at approximately 350 K. The resolution of the specific heat according to the local structure shows that the excess specific heat arises predominantly from the grain boundaries.
Exaggerated IL-8 and IL-6 responses to TNF-α by parainfluenza virus type 4-infected NCI-H292 cells (2004)

Respiratory viruses induce and potentiate airway inflammation, which is related to the induction of proinflammatory mediators such as interleukin (IL)-8 and IL-6. Here we report on mechanisms implicated in IL-8 and IL-6 production by airway epithelium-like NCI-H292 cells exposed to parainfluenza virus type 4a (PIV-4). PIV-4 readily infected NCI-H292 cells as reflected by intracellular PIV-4 antigen expression. PIV-4 infection triggered a biphasic IL-8 and IL-6 mRNA response. Transient transfection with truncated and mutated promoter constructs identified NF-kappaB and activator protein (AP)-1, and CCAAT-enhancer binding protein (C/EBP) as the relevant transcription factors for PIV-4-induced IL-8 and IL-6 gene transcription, respectively. An increase of DNA-binding activities for NF-kappaB and C/EBP paralleled the induction of the first and second IL-8 and IL-6 mRNA peaks, whereas the onset of AP-1 paralleled the first IL-8 mRNA peak only. The second mRNA peak, apparently dependent on viral replication, coincided also with a marked reduction of IL-8 and IL-6 mRNA degradation. Importantly, cells at the time of the reduced mRNA degradation displayed an exaggerated IL-8 and IL-6 protein production to a secondary stimulus, as exemplified by steeper dose-response curves to TNF-alpha. Thus PIV-4 infection enhances epithelial IL-8 and IL-6 production by transcriptional and posttranscriptional mechanisms. The previously unrecognized phase of reduced IL-8 and IL-6 mRNA degradation and the concurrent amplified epithelial IL-8 and IL-6 responses may play an important role in virus-induced potentiation of airway inflammation.
Impact of prospective motion correction, distortion correction methods and large vein bias on the spatial accuracy of cortical laminar fMRI at 9.4 Tesla (2019)

Functional imaging with sub-millimeter spatial resolution is a basic requirement for assessing functional MRI (fMRI) responses across different cortical depths and is used extensively in the emerging field of laminar fMRI. Such studies seek to investigate the detailed functional organization of the brain and may develop to a new powerful tool for human neuroscience. However, several studies have shown that measurement of laminar fMRI responses can be biased by the image acquisition and data processing strategies. In this work, measurements with three different gradient-echo EPI BOLD fMRI protocols with a voxel size down to 650 ​μm isotropic were performed at 9.4 ​T. We estimated how prospective motion correction can help to improve spatial accuracy by reducing the number of spatial resampling steps in postprocessing. In addition, we demonstrate key requirements for accurate geometric distortion correction to ensure that distortion correction maps are properly aligned to the functional data and that strong variations of distortions near large veins can lead to signal overlays which cannot be corrected for during postprocessing. Furthermore, this study illustrates the spatial extent of bias induced by pial and other larger veins in laminar BOLD experiments. Since these issues under investigation affect studies performed with more conventional spatial resolutions, the methods applied in this work may also help to improve the understanding of the BOLD signal more broadly.
Evaluation of Biomechanical Stability of Newly Developed Revision Total Knee Arthroplasty through Strain and Stress Distribution Analysis within the Tibia: Finite Element Analysis (2013)

In this study, biomechanical stability of the newly developed revision total knee arthroplasty (rTKA) was evaluated through strain and stress distribution analysis within the implanted proximal tibia using a three-dimensional finite element (FE) analysis. 2000N of compressive load (about 3 times body weight) was applied to the condyle surface on spacer, sharing by the medial (60%) and lateral (40%) condyles simulating a stance phase before toe-off. The results showed that PVMS within the revision total knee arthroplasty and the proximal tibia were less than yield strength considering safe factor 4.0 (rTKA: less than 10%, Cortical bone: less than 70%, Cancellous bone: less than 70%). The materials composed of them and the strain and stress distributions within the proximal tibia were generally well matched with those of a traditional revision total knee arthoplasty (Scorpio TS revision system, Stryker Corp., Michigan, USA) without the critical damage strain and stress, which may reduce the capacity for bone remodeling, leading to bone degeneration. This study may be useful to design parameter improvement of the revision total knee arthoplasty in biomechanical stability point of view beyond structural stability of revision total knee arthoplasty itself.
An Asymptotic Study of Hierarchical Diversity Receptions Over Rician Channels With Arbitrary Correlation (2015)

Hybrid-selection maximal-ratio combining (HS/MRC) is a useful diversity reception technique to reduce the number of radio frequency chains, and this diversity scheme has been well studied. However, past studies on HS/MRC have often ignored the significant insertion loss associated with hardware implementation of HS/MRC. Therefore, we consider a special class of two-stage diversity receptions known as hierarchical diversity with low insertion loss. The asymptotic error rate performances of hierarchical selection-combining MRC (SC-MRC) and hierarchical selection-combining equal-gain combining are studied for Rician fading channels with arbitrary correlation. Based on our asymptotic analysis, it is shown that, for a practical number of antenna branches, SC-MRC will suffer, at most, 0.6-dB performance losses with respect to HS/MRC; however, SC-MRC will incur significantly less insertion loss. Based on closed-form asymptotic error expressions, we also study unique transmission properties of two-stage diversity receptions over Rician channels with arbitrary branch correlation.
Vibroacoustical preventive method for non-destructive testing and evaluation of rotative bladed systems (1999)

Method uses spectral component parameters of vibroacoustical noise of systems as features. Estimation of mentioned parameters allows evaluation of the levels of mechanical and aerodynamic loadings of rotative bladed systems. Experimental results with aircraft gas turbine engine are presented.
Abstract 2108: Chromatin state as a mechanism of anthracycline response in breast cancer (2019)

The aim of this study is to determine the effect of chromatin regulators on anthracycline response in breast cancer. Anthracyclines are a highly effective component of curative breast cancer chemotherapy, but can be associated with substantial side effects. Because anthracyclines work in part via inhibition of topoisomerase II (TOP2) on accessible DNA, we hypothesized that expression levels of chromatin regulatory proteins that mediate DNA accessibility might predict anthracycline response. We used RNA-sequencing data from the TCGA breast cancer cohort to infer a breast cancer chromatin regulatory network using the ARACNE algorithm. A panel of 45 breast cancer cell lines with accompanying gene expression and growth inhibitory (GI50) data was used to build a genome-wide signature of anthracycline response. Based on the GI50, cell lines were classified as sensitive or resistant. The VIPER algorithm was then used to identify chromatin regulatory genes (CRGs) from the ARACNE network whose targets were significantly enriched in the anthracycline resistance signature. We further compiled a metacohort of 1006 clinically annotated early-stage breast cancer patients with gene expression data, allowing us to identify CRGs whose expression levels were associated with outcome after adjuvant treatment with anthracyclines. 24 CRGs associated (P Citation Format: Jose A. Seoane, Jacob G. Kirkland, Jennifer L. Caswell-Jin, Gerald R. Crabtree, Christina Curtis. Chromatin state as a mechanism of anthracycline response in breast cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 2108.
Hybrid III–V/Silicon Technology for Laser Integration on a 200-mm Fully CMOS-Compatible Silicon Photonics Platform (2019)

In this paper, we present the hybrid III-V/Si photonic platform developed in CEA-LETI. The overall integration is done in a fully CMOS compatible 200-mm technology, scalable to 300-mm wafers, leveraging the large-scale integration capabilities of silicon photonics. III-V material is integrated on top of a mature silicon photonic front-end wafer through direct molecular bonding enabling the monolithic integration of light sources. DFB and distributed Bragg reflector (DBR) laser reference designs are used as test vehicles for the process validation. A modular approach is used in order to minimize the impact on the already qualified silicon-based devices. Collective III-V die bonding is proposed in this platform. CMOS compatible metallizations are used to form ohmic contact on n-InP and P-InGaAs leading to contact resistivity in the range of 10 <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-6</sup> Ω·cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> . A planarized two-metal-level BEOL is used to connect the device, leading to a drastic reduction of series resistance. Finally, the functionality of both types of lasers is demonstrated with SMSR up to 50 dB and maximum output power of 5 mW.
Topology and Polarization of Optical Vortex Fields from Atomic Phased Arrays (2022)

We developed theoretical formalism for generation of optical vortices by phased arrays of atoms. Using Jacobi-Anger expansion, we demonstrate the resulting field topology and determine the least number of array elements necessary for generation of vortices with a given topological charge. Vector vortices were considered, taking into account both spin and orbital angular momenta of electromagnetic fields. It was found that for the vortex field near the phase singularity, the transverse-position dependence of 3D polarization parameters is independent of the distance to the radiation source.