gebhart/patrepeval huggingface dataset:
Measure of controllability for actuator placement (1991)

A new measure of controllability for linear time invariant dynamical systems is introduced. The controllability measure is designed especially to guide the placement of actuators to control vibrating structures. An example is presented, and the design of optimal feedback control laws for each of several actuator configurations supports the practical value of the new controllability measure.
Lysosomal isoenzyme profiles used to classify a case of acute undifferentiated leukaemia (1985)

Lysosomal enzyme activities and isoenzyme profiles were measured in lymphoid and non-lymphoid leukaemic cells from childhood patients. High activities, especially of beta-hexosaminidase and alpha-mannosidase, were associated with leukaemic cells of myeloid or monocytic origin. Leukaemic cells from two children with acute myeloid leukaemia had a relative reduction in the B isoenzyme of beta-hexosaminidase activity, whereas in patients with non T, non B cell acute lymphoblastic leukaemia, intermediate beta-hexosaminidase isoenzymes were expressed. A patient is described on whom conventional marker studies were either negative or equivocal, but lysosomal enzyme markers were consistent with a myeloid leukaemia. This observation was supported by the clinical course of this patient.
Matching pursuits based multiple description video coding for lossy environments (2004)

Multiple description coding (MDC) is an error resilient source coding scheme that creates multiple descriptions of the source with the aim of providing an acceptable reconstruction quality when only one description is received, and improved quality as more descriptions become available. Recently, we developed a matching pursuit multiple description video coder (MP-MDVC) based on a three loop structure originally proposed by Reibman and her colleagues (MTDC). While the MP-MDVC outperforms the discrete cosine transform based MTDC. it is not optimized for lossy environments. In this paper, we extend MP-MDVC by considering the network loss characteristics when coding multiple descriptions. In particular, we propose a fast steepest descent algorithm for creating multiple descriptions that results in minimum expected distortion, given network outage probability, bandwidth constraints, and maximum allowable distortion for each description. Analytical and experimental results show that by taking network loss characteristics into account, our approach outperforms existing MP-MDVC techniques.
Toward integrated design tools: analysis of wave-semiconductor device interactions (2002)

Discusses the interactions between semiconductor devices and electromagnetic waves and the possible ways to interface modern devices and circuits in the mm-wave range. The electromagnetic wave propagation through semiconductor devices is modeled by coupling a physical electron-transport model with Maxwell's equations. The solution is developed in the time-domain using the finite-difference time-domain (FDTD) technique. The signal propagation through the passive part of the circuit is analyzed by solving Maxwell's equations using the FDTD technique. The models are implemented and used for studying circuits with operating frequencies from the microwaves up to the optical range. Several examples of device and circuit simulations will be presented.
High-pressure studies of pharmaceutical compounds (2008)

Browser selection panel for 7 crystal families, crystal classes (point groups), individual space groups; Symmetry selection menu by type, angle, translation, orientation, location, generator; Change cell type; Mouse control to rotate/translate visualization and interactively animate, select, and remove single symmetries; General position (mouse) interaction: rotation/motion of general position symbols; Vary number of cells in view, vary cell angles and lengths; Orthographic projection, stereo colors (cinema type stereo view); Save visualization as image file. We will present the unique mathematical and algorithmic structure underlying the visualization software using a coordinate free approach to symmetry with Geometric Algebra. We demonstrate the powerful set of interactive visualization tools made available by the SGV. Free demo at www.spacegroup.
Study of Internal and External Leaks in Tests of Anode‐Supported SOFCs (2008)

Abstract A planar anode‐supported solid oxide fuel cell (SOFC) has been tested to investigate gas tightness of the electrolyte and the applied seals. Gas leaks reduce the efficiency of the SOFC and it is thus important to determine and minimise them. Probe gases (He and Ar) and a Quadrupole Mass Spectrometer were used to detect both internal (through electrolyte) and external (through seals) gas leaks. The internal gas leak through the electrolyte was quantified under different conditions, as was the external leak from the surroundings to the anode. The internal gas leak did not depend on the pressure difference between the anode and the cathode gas compartment, and can thus be described as diffusion driven. External leaks between the surroundings and the anode, but not the cathode gas compartment was observed. They were influenced by the pressure difference and are thus driven by both concentration and pressure gradients. The measured gas leaks deduced from the probe gas experiments and the total leak calculated from the deviation between the Emf defined by the gases and the cell OCV (which contains all gas leaks as well as effects of electronic leaks) were compared. Good agreement between the two measures was observed.
A Reusable Surface-Enhanced Raman Scattering (SERS) Substrate Prepared by Atomic Layer Deposition of Alumina on a Multi-Layer Gold and Silver Film (2011)

A thermally stable, reusable surface-enhanced Raman scattering (SERS) substrate consisting of a gold/silver bi-layer film with a protective alumina coating is reported. The film is synthesized by thermally evaporating sequential layers of gold and silver followed by coating an ultra-thin alumina layer using atomic layer deposition. The use of gold as the foundational layer improves the thermal stability of the metal bi-layer film while providing the additional ability to tune the SERS response. Deposition of the thin alumina overlayer on the bi-layer film creates a SERS substrate capable of enduring multiple high-temperature exposures to 400 °C with minimal loss of enhancement capabilities. We demonstrate the multi-use capability of the substrate by measuring the SERS spectrum of rhodamine 6G followed by a thermal treatment at 400 °C to remove the analyte. A representative substrate was used to acquire SERS spectra of rhodamine 6G up to five repeat measurements, thus establishing the reusability of this relatively simple, inexpensive, and stable substrate.
Simultaneous Determination of Donepezil and Its Three Metabolites in Human Plasma Using LC–MS-MS (2016)

A simple and selective assay for the determination of donepezil (Aricept(®)) and its three metabolites including 6-O-desmethyl (M1), 5-O-desmethyl (M2) and N-oxide (M6) metabolites in human plasma was developed and validated using liquid chromatography with tandem mass spectrometry. An analog of donepezil was used as an internal standard (IS) for all the analytes. The analytes and the IS were extracted from plasma by solid-phase extraction. The analytes were chromatographically separated on Cadenza CD-C18 column with gradient elution, then detected with electrospray positive ionization in multiple reaction monitoring mode. The established method showed linearity ranging 0.5-100 ng/mL for donepezil and 0.2-40 ng/mL for all three metabolites and was fully validated in accordance with bioanalytical guidelines. Selectivity, clear peak separation and no carryover were ensured for all the analytes. The intra- and inter-batch reproducibility assessments demonstrated that accuracy and precision were within the acceptance criteria. Minimal matrix effects and consistent extraction recovery were noted. Stability assessment demonstrated that all the analytes were stable for at least 184 days at -20°C. Assay of post-dose samples also showed clear peak separation of the analytes, indicating successful clinical application.
Global survey of military HIV / AIDS policies and programs. (1997)

This position paper on Civil-Military Collaboration for HIV/AIDS Prevention and Mitigation in Africa is in three parts. The first to establish the current reality in military AIDS prevention is a report on a world-wide survey of policies in place today in military prevention programs. Part II addresses policy issues in current military medical practices and is presented as a series of questions key facts and specific military issues. These include testing foreign military training peacekeeping and issues of AIDS care in militaries. Part III discusses emerging HIV/AIDS policy trends in African militaries particularly around such issues as the spread of the HIV virus AIDS illness and death survivors long-term care and the overall security impact. (authors)
Evaluation of Prima Light Falling-Weight Deflectometer as Quality Control Tool for Compaction of Fine Grained Soils (2007)

Compaction of embankment soils is a key factor influencing premature pavement distresses. The current specifications of the Kansas Department of Transportation (KDOT) address embankment compaction in terms of density and moisture content. However, the implementation of performance based specifications would require measuring in situ stiffness, in addition to density, because soil stiffness is the parameter employes when pavement structures designed. The investigated the use of the Prima 100 Light Falling Weight Deflectometer (L-FWD) to measure in-situ soil stiffness and the feasibility of developing a stiffness based specification for embankment soil compaction quality control that uses the L-FWD measured stiffness. To achieve the objectives, soil stiffness values were measured at multiple locations along eight KDOT embankment projects using the Prima L-FWD. Concurrent density and moisture measurements were also taken at select locations. Laboratory resilient moduli tests were performed on remolded soil samples at several density and moisture contents. For each soil, regression models were derived from the laboratory resilient modulus data to predict the in-situ modulus. It was found that the predicted in-situ resilient moduli did not correlate with the in-situ measured moduli. Therefore, it was not possible to develop a quality control scheme for embankment soil stiffness that employs stiffness requirements established based on the results of laboratory resilient modulus tests. In addition, the testing proved that the in-situ modulus of fine grained soils has a high degree of spatial variability. This prevented the development of a quality control procedure based on stiffness measured on a control test strip.
Management of personal information scraps (2007)

We introduce research on information scraps. short, self-contained personal notes that fall outside of traditional filing schemes. We report on a preliminary study of information scraps. nature and outline plans for the next phase of our user study. Based on ongoing study results, we describe our designs and prototypes for information scrap capture and access tools.
Fibroblast Growth Factor 18 Influences Proximal Programming during Lung Morphogenesis (2002)

The structure and functions of the airways of the lung change dramatically along their lengths. Large-diameter conducting airways are supported by cartilaginous rings and smooth muscle tissue and are lined by ciliated and secretory epithelial cells that are involved in mucociliary clearance. Smaller peripheral airways formed during branching morphogenesis are lined by cuboidal and squamous cells that facilitate gas exchange to a network of fine capillaries. The factors that mediate formation of these changing cell types and structures along the length of the airways are unknown. We report here that conditional expression of fibroblast growth factor (FGF)-18 in epithelial cells of the developing lung caused the airway to adopt structural features of proximal airways. Peripheral lung tubules were markedly diminished in numbers, whereas the size and extent of conducting airways were increased. Abnormal smooth muscle and cartilage were found in the walls of expanded distal airways, which were accompanied by atypically large pulmonary blood vessels. Expression of proteins normally expressed in peripheral lung tubules, including SP-B and pro-SP-C, was inhibited. FGF-18 mRNA was detected in normal mouse lung in stromal cells surrounding proximal airway cartilage and in peripheral lung mesenchyme. Effects were unique to FGF-18 because expression of other members of the FGF family had different consequences. These data show that FGF-18 is capable of enhancing proximal and inhibiting peripheral programs during lung morphogenesis.
High-Quality Wavelet Splatting for Volume Rendering (1998)

We extended Gross&amp;apos;s et al. [1,3] method of volume wavelet rendering by computing splats via least squares approximation. The method decomposes the volume data into a wavelet pyramid representation in the B-spline domain. The splats of the basis functions are projected onto a multiresolution grid. The approximation error on the grid is derived, applying [2], as a function of the sampling step h. Choosing at each step the appropriate wavelet space and spatial resolution produces the smallest possible filters and reduces computation. Our approach ensures a maximal image quality when rendering at low resolution. keywords: volume rendering, wavelet splat, approximation theory, multiresolution Motivation Volume rendering is a useful technique for biomedical and geological data visualisation. It is computationally expensive and consumes a lot of memory and bandwidth. Fast implementations rely on hardware rendering and rather coarse approximations. A user would like to browse interactively around and through a volume to get a better imagination of its three-dimensionality. One might accept the compromise of lower image resolution or quality for the sake of fast feedback. Then once a view point of the volume has been chosen, the quality improves. Especially physicians need a high visualisation quality to get reliable diagnosis.
In vitro assessment of the pharmacodynamic properties and the partitioning of OZ277/RBx-11160 in cultures of Plasmodium falciparum (2006)

The present study indicates similar stage-specific profiles for OZ277 and for the more well-established antimalarial agents artemether and chloroquine. Secondly, the study describes a significant accumulation of radiolabelled OZ277 in P. falciparum-infected RBCs.
Electric Dyadic Green's Functions for Modeling Resonance and Coupling Effects in Waveguide-Based Aperture-Coupled Patch Arrays (2002)

An efficient technique for the rapid devel- opment of electric Green's dyadics of a transversely layered, terminated rectangular waveguide is presented with application to waveguide-based aperture-coupled patch arrays. This technique uses a partial eigenfunc- tion expansion resulting in a Sturm-Liouville problem for one-dimensional characteristic Green's functions in the waveguiding direction. In this representation, the one-dimensional characteristic Green's functions pro- vide physical insight into resonance and surface wave effects occurring in overmoded layered waveguide tran- sitions. Particularly, this is related to the correlation between transverse resonances in the waveguide cross- section and surface waves associated with a grounded dielectric slab waveguide. This is demonstrated for the examples of aperture-coupled patch arrays in the N- port waveguide transition, although the analysis is ap- plicable to other waveguide-based antenna structures, which allow for the propagation of surface waves.
Tensile strength of aluminium nitride films (2004)

Two-layered aluminium nitride (AlN)/silicon nitride microbridges were fabricated for microbridge tests to evaluate the elastic modulus, residual stress and tensile strength of the AlN films. The silicon nitride layer was added to increase the robustness of the structure. In a microbridge test, load was applied to the centre of a microbridge and was gradually increased by a nano-indenter equipped with a wedge tip until the sample was broken, while displacement was recorded coherently. Measurements were performed on single-layered silicon nitride microbridges and two-layered AlN/silicon nitride microbridges respectively. The data were fitted to a theory to derive the elastic modulus, residual stress and tensile strength of the silicon nitride films and AlN films. For the AlN films, the three parameters were determined to be 200, 0.06 and 0.3 GPa, respectively. The values of elastic modulus obtained were consistent with those measured by conventional nano-indentation method. The tensile strength value can be used as a reference to reflect the maximum tolerable tensile stress of AlN films when they are used in micro-electromechanical devices.
Comments on "Determination of Si-SiO/sub 2/ interface trap density by 1/f noise measurements" [with reply] (1990)

For the original article see ibid., vol.35, p.1651-5 (1988). The author comments on the interface state density determined by means of measurements of the 1/f noise at cryogenic temperatures. A suspiciously high density (10/sup 23/ cm/sup -3/ eV/sup -1/) was recently determined by Z. Celik-Butler and T.Y. Hsiang in the above-mentioned paper. It is argued that this value is contradictory to a determination by other techniques such as deep-level transient spectroscopy (DLTS) that are more specifically devoted to the study of defects in devices. A detailed reply by Celik-Butler and Hsiang is included.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Supplementary Data from Increased Levels of Urinary PGE-M, a Biomarker of Inflammation, Occur in Association with Obesity, Aging, and Lung Metastases in Patients with Breast Cancer (2023)

Supplementary Data from Increased Levels of Urinary PGE-M, a Biomarker of Inflammation, Occur in Association with Obesity, Aging, and Lung Metastases in Patients with Breast Cancer
Evaluation of the Tetrakis(3-Hydroxy-4-Pyridinone) Ligand THPN with Zirconium(IV): Thermodynamic Solution Studies, Bifunctionalization, and in Vivo Assessment of Macromolecular <sup>89</sup>Zr-THPN-Conjugates (2019)

Zirconium-89 (<sup>89</sup>Zr) is a suitable radionuclide for positron-emission tomography (PET) of long-circulating targeting vectors such as monoclonal antibodies (mAbs). Due to stability concerns for the most widely used <sup>89</sup>Zr-chelating agent desferrioxamine B (DFO) in preclinical studies, alternative <sup>89</sup>Zr-chelators are currently being developed. We recently reported on the first tetrakis(3-hydroxy-4-pyridinone) (3,4-HOPO) ligand THPN, which was identified as a promising <sup>89</sup>Zr-chelator. In this study, we aimed to further explore this octadentate chelate in vitro and in vivo. The [Zr<sup>IV</sup>(THPN)] thermodynamic stability was quantified in solution titration studies, which revealed one of the highest formation constants reported for a zirconium chelate (log β<sub>ML</sub> 50.3(1), pM = 42.8). Solution stabilities with iron(III) were also exceptionally high and can compete with some of the strongest Fe<sup>III</sup>-chelates. A first bifunctional derivative of the octadentate ligand, <i>p</i>-SCN-Bn-THPN, was then produced in a multistep synthesis. To assess and compare the long-term <sup>89</sup>Zr complex stability, bifunctional THPN, as well as the literature chelators <i>p</i>-SCN-Phe-DFO and <i>p</i>-SCN-Phe-DFO*, were conjugated to the high-molecular weight (800 kDa) polymeric carrier hyperbranched polyglycerol (HPG). The functionalized HPGs were radiolabeled with <sup>89</sup>Zr<sup>IV</sup>, and the integrity of the radioconjugates was assessed over several days in vitro and in vivo. While all three radioconjugates remained >95% intact over 5 days in human plasma, the in vivo study in healthy mice revealed higher physiologic stability of the DFO and DFO* radiochelates over bifunctional THPN conjugates. This was evidenced by increased bone uptake of osteophilic <sup>89</sup>Zr<sup>IV</sup> for THPN. This finding contrasts with the exceptionally high thermodynamic stability of the chelate and suggests either a kinetic or metabolic lability, or may stem from coordinative changes due to the covalent conjugation of the <sup>89</sup>Zr-THPN radiochelate as suggested by density functional theory (DFT) calculations. These important findings inform the design of next generation 3,4-HOPO chelates with the aim of improving the physiologic stability. This study furthermore demonstrates how HPG can be used as a robust carrier tool to assess and compare the long-term in vivo stability of radiochelates.
Synthesis of N-methyl- and 5-HO-[18F]fluorotryptophans (2019)

Tryptophan (Trp) metabolism is altered in numerous pathological processes. 7-[F-18]FTrp developed in our group is a promising PET-tracer for imaging of Trp metabolism but is unable to distinguish between the two pathways of Trp metabolization. The aim of this project was the development of procedures for the preparation of NinMe-6- and 5-HO-7-[F-18]FTrp as PET-probes suitable for selective visualization of the kynurenine or serotonin pathway.
Identification of Mengo Virus T Helper Cell Epitopes (1994)

To identify Mengo virus-specific T cell epitopes in mice (the natural host for the virus), lymph node cells were obtained from BALB/c (H-2d) mice, previously immunized with u.v.-inactivated virus, and stimulated in vitro with each of 116 overlapping peptides (10 to 18 residues long) covering the entire capsid coding region (834 amino acids). T cell epitopes were defined on the basis of specific peptide-induced lymphocyte proliferation. Where proliferation occurred, immunological characterization showed that it was the CD4+ T helper (Th) cell subpopulation that was responsible for the Mengo virus-specific response. Surprisingly, no Mengo virus Th cell epitopes were found in capsid protein VP1 or VP4. Six peptides in VP2 (residues 1 to 15, 99 to 108, 118 to 132, 133 to 147, 227 to 236 and 247 to 256) identified the positions of separate Th cell epitopes, and two overlapping peptides (residues 173 to 182 and 178 to 192) defined an additional Th cell immunogenic sequence. Three individual peptides in VP3 (residues 46 to 58, 136 to 150 and 198 to 212) and two overlapping peptides (residues 1 to 15 and 11 to 20) also represent Th cell epitopes. Similar assays with C57BL/6 (H-2b) and SJL/J (H-2s) mice showed that the pattern of recognition of these peptides was H-2 restricted. Each of the previously identified sites of B cell antigenicity in VP2 and VP3 are associated with one Th epitope. Comparison of the experimentally determined Th epitopes with potential T cell epitopes identified by several predictive strategies revealed only a low correlation between authentic and predicted epitopes.
ChemInform Abstract: Studies on Pyrrolidinones: Some Attempts to Improve the Synthesis of Methyl N‐(3,4,4′,5‐Tetramethoxybenzhydryl)pyroglutamate (HEI 81) by Using N‐Acyl Iminium Salts Methodologies. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.