gebhart/patrepeval huggingface dataset:
Assessment of human scent volatiles for the discrimination of individuals (2010)

Human scent, or the volatile organic compounds (VOCs) produced by an individual, has been recognized as a biometric measurement because of the distinct variations in both the presence and abundance of these VOCs between individuals. In forensic science, human scent has been used as a form of associative evidence by linking a suspect to a scene/object through the use of human scent discriminating canines. The scent most often collected and used with these specially trained canines is from the hands because a majority of the evidence collected is likely to have been handled by the suspect. However, the scents from other biological specimens, especially those that are likely to be present at scenes of violent crimes, have yet to be explored. Hair, fingernails and saliva are examples of these types of specimens. ^ In this work, a headspace solid phase microextraction gas chromatography-mass spectrometry (HS-SPME-GC-MS) technique was used for the identification of VOCs from hand odor, hair, fingernails and saliva. Sixty individuals were sampled and the profiles of the extracted VOCs were evaluated to assess whether they could be used for distinguishing individuals. Preliminary analysis of the biological specimens collected from an individual (intra-subject) showed that, though these materials have some VOCs in common, their overall chemical profile is different for each specimen type. Pair-wise comparisons, using Spearman Rank correlations, were made between the chemical profiles obtained from each subject, per a specimen type. Greater than 98.8% of the collected samples were distinguished from the subjects for all of the specimen types, demonstrating that these specimens can be used for distinguishing individuals. ^ Additionally, field trials were performed to determine the utility of these specimens as scent sources for human scent discriminating canines. Three trials were conducted to evaluate hair, fingernails and saliva in comparison to hand odor, which was considered the standard source of human odor. It was revealed that canines perform similarly to these alternative human scent sources as they do to hand odor implying that, though there are differences in the chemical profiles released by these specimens, they can still be used for the discrimination of individuals by trained canines.
A 1000x utility-scale parabolic frame tracker for multidisciplinary CPV research (2017)

A dual-dish concentrating solar research system is introduced in which multiple low-cost single-axis-focusing mirrors have their foci overlapped into a single intense compound focus. A CPV receiver for such a focus is also introduced, with cooled secondary mirrors and a Dense Receiver Array (DRA) with shingled cell rows to eliminate inter-row gaps. CTE-matched micro-channel cold plates are used for low-resistance cooling and fin tube radiators provide ample heat-rejection surface. The ratio of the DRA’s cell area to focusing mirrors’ area allows reaching a concentration factor of 1000x. A cost breakdown is presented and discussed and areas that still need significant improvement to be able to compete with flat panel costs are identified, along with research works in progress in those areas.
Supplementary Data from Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates &lt;i&gt;CXCR4&lt;/i&gt; mRNA Expression Levels to Potential Clinical Targets (2023)

Supplementary Data from Multi-omic Characterization of Pancreatic Ductal Adenocarcinoma Relates &lt;i&gt;CXCR4&lt;/i&gt; mRNA Expression Levels to Potential Clinical Targets
Design for Fragility + Justice (2022)

Iredale Pedersen Hook architects is an internationally acclaimed design practice based in Perth and Melbourne, Australia. The studio practises in the fields of housing, education, health, justice, and cultural buildings with a focus on direct engagement with the Indigenous peoples of Australia.
Dose-Dependent Thermal Response of Tumor pH and Energy Metabolism Evaluated by in Vivo 31 P NMR Spectroscopy and Microelectrodes (1991)

In vivo 31P NMR spectroscopy and pH microelectrodes were employed to measure the energy metabolism and pH of a mammary carcinoma in the flank of the C3H mouse before and serially up to a week after various hyperthermia treatments. Water bath hyperthermia was used to treat the tumor at 43.5 degrees C for 30 min (TCD0/30, NMR measurement only), 1 h (TCD10/30), and 2 h (TCD60/30), respectively. The data indicate that, except at 4 h after TCD60/30 treatment, all pH values measured by NMR (pHn) were significantly higher (P less than or equal to 0.001) compared to pH values measured by microelectrodes (pHe) at all treatment levels and times. The magnitude of the difference between pHn and pHe (delta pH) was significantly decreased from the pretreatment level only at 4 h after hyperthermia treatment (0.51 pH units for TCD60/30 and 0.21 pH units for TCD10/30). The ratio of beta-nucleoside triphosphate to inorganic phosphate (beta-NTP/Pi) and pHn were more sensitive to hyperthermia treatment than pHe. The beta-NTP/Pi ratio failed to recover to the pretreatment ratio after 1 or 2 h hyperthermia treatment, while a total recovery was observed within 72 h for 30 min hyperthermia treatment. Our data suggest that the temporal profile of beta-NTP/Pi, pHn, and delta pH may be indicative of the biological outcome of hyperthermia treatment.
Obtaining Uniform Dopant Distributions in VLS-Grown Si Nanowires (2010)

Semiconducting nanowires grown by the vapor-liquid-solid method commonly develop nonuniform doping profiles both along the growth axis and radially due to unintentional surface doping and diffusion of the dopants from the nanowire surface to core during synthesis. We demonstrate two approaches to mitigate nonuniform doping in phosphorus-doped Si nanowires grown by the vapor-liquid-solid process. First, the growth conditions can be modified to suppress active surface doping. Second, thermal annealing following growth can be used to produce more uniform doping profiles. Kelvin probe force microscopy and scanning photocurrent microscopy were used to measure the radial and the longitudinal active dopant distribution, respectively. Doping concentration variations were reduced by 2 orders of magnitude in both annealed nanowires and those for which surface doping was suppressed.
Figure S2 from Targeting MET and FGFR in Relapsed or Refractory Acute Myeloid Leukemia: Preclinical and Clinical Findings, and Signal Transduction Correlates (2023)

&lt;p&gt;Merestinib and LY2874455 inhibit MET-activated signal transduction. A, AML cell lines treated with merestinib and LY2874455 in vitro for 1 hour exhibited decreased levels of pSTAT3 and pSTAT5 by phospho-flow cytometry. Standard errors are shown for KG1a (n=3) and HEL (n=2) cell lines. Representative flow cytometry histograms are shown in B. Reverse transcription-PCR showing decreased expression of CISH, a downstream target of STAT5, is displayed in C. Abbreviations: U = unstained; FGFRi = the FGFR inhibitor LY2874455.&lt;/p&gt;
Assessment of Pharmacokinetic Linearity and Relative Bioavailability of an Intranasal Diazepam Formulation Compared with Diazepam Rectal Gel in Healthy Adult Subjects (P02.214) (2013)

OBJECTIVE: To evaluate dose proportionality between 5 and 20mg DZNS formulations, and to assess the relative bioavailability of a single 20mg DZNS dose versus 20mg DRG.
P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression (2021)

Glioblastoma (GB) is a highly invasive type of brain cancer exhibiting poor prognosis. As such, its microenvironment plays a crucial role in its progression. Among the brain stromal cells, the microglia were shown to facilitate GB invasion and immunosuppression. However, the reciprocal mechanisms by which GB cells alter microglia/macrophages behavior are not fully understood. We propose that these mechanisms involve adhesion molecules such as the Selectins family. These proteins are involved in immune modulation and cancer immunity. We show that P-selectin mediates microglia-enhanced GB proliferation and invasion by altering microglia/macrophages activation state. We demonstrate these findings by pharmacological and molecular inhibition of P-selectin which leads to reduced tumor growth and increased survival in GB mouse models. Our work sheds light on tumor-associated microglia/macrophage function and the mechanisms by which GB cells suppress the immune system and invade the brain, paving the way to exploit P-selectin as a target for GB therapy.
The Role of Collagen Crosslinking in Differentiation of Human Mesenchymal Stem Cells and MC3T3-E1 Cells (2009)

Collagen is the main protein component of the extracellular matrix of bone, and it has structural and instructive properties. Collagen undergoes many post-translational modifications, including extensive crosslinking. Although defective crosslinking has been implicated in human syndromes (e.g., osteogenesis imperfecta or Ehlers-Danlos syndrome), it is not clear to what extent crosslinking is necessary for collagen's instructive properties during bone formation. Here we report that inhibition of collagen crosslinking in the mouse pre-osteoblast cell line MC3T3-E1 impairs the osteogenic program. Genome-wide expression profiling of beta-aminopropionitrile-treated and control cells revealed that matrix deposition by MC3T3-E1 cells provides a feed back signal, driving cells through the differentiation process, that is strongly impaired when crosslinking is inhibited. Inhibition of crosslinking did not affect osteogenic differentiation of human mesenchymal stem cells (hMSCs), shown by the expression of alkaline phosphatase and genome-wide gene expression analysis, although it enhances matrix mineralization. In conclusion, collagen crosslinking harbors instructive properties in MC3T3-E1 differentiation but plays a more-passive role in differentiation of bone marrow-derived hMSCs.
Hematin-catalyzed epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene by polyunsaturated fatty acid hydroperoxides. (1985)

Hematin catalyzes the epoxidation of 7,8-dihydroxy-7,8-dihydrobenzo[a]pyrene (BP-7,8-diol) by 13-hydroperoxy-9-cis,11-trans-octadecadienoic acid and other fatty acid hydroperoxides in the presence of detergent. The major oxidation product is the anti-dihydrodiolepoxide and the minor product is the syn-dihydrodiolepoxide. (+)-BP-7,8-diol is oxidized to (-)-anti-diolepoxide and (+)-syn-diolepoxide whereas (-)-BP-7,8-diol is oxidized to (+)-anti-diolepoxide and (-)-syn-diolepoxide. Oxygen labeling studies indicate that the source of the epoxide oxygen is O2. The phenolic antioxidants butylated hydroxyanisole and butylated hydroxytoluene inhibit epoxidation by 100 and 93%, respectively. These observations suggest that hematin-catalyzed epoxidation proceeds by a free radical mechanism. Incubation of hematin, BP-7,8-diol, and a series of fatty acid hydroperoxides containing two, one, or zero double bonds alpha to the carbon bearing the hydroperoxide indicates that at least one double bond is essential for generation of the epoxidizing agent. Taken with results of the study of the metabolism of 13-hydroperoxy-9-cis,11-trans-octadecadienoic acid by hematin described in the accompanying paper (Dix, T. A., and Marnett, L. J. (1985) J. Biol. Chem. 260, 5351-5357), these results indicate that the epoxidizing agent is a peroxyl radical generated by coupling of O2 to a carbon-centered radical derived from the double bonds adjacent to the hydroperoxide group. The detergents Tween 20, Triton X-100, and Triton X-405 dramatically enhance epoxidation above but not below their critical micellar concentrations. The intensity and lambda max of the ultraviolet absorption spectrum of BP-7,8-diol increase in the presence of detergent, indicating that an important role of detergent is solubilization of the hydrophobic substrate. However, detergent also stimulates the hematin-catalyzed oxidation of a water-soluble polycyclic hydrocarbon, bis-(carboxyethyl)-anthracene, suggesting that detergent has an effect on the peroxidase activity of hematin. A detailed mechanism for epoxidation of BP-7,8-diol by hematin and fatty acid hydroperoxides is presented and its relevance to other hydroperoxide-dependent epoxidizing systems is discussed.
Addendum: "On the nature of the phase transition in the itinerant helimagnet MnSi", arXiv:cond-mat/0702460v1 [cond-mat.str-el] (2007)

New high resolution data for heat capacity, heat capacity under applied magnetic fields and resistivity of high quality single crystal of MnSi are reported. Striking mirror symmetry between temperature derivative of resistivity and thermal expansion coefficient of MnSi is displayed. Close similarity between variation of the heat capacity and the temperature derivative of resistivity through the phase transition is observed. It is shown that the heat capacity and thermal expansion coefficient of the helical phase are not influenced by moderate magnetic field.
A Novel Operon Encoding Formaldehyde Fixation: the Ribulose Monophosphate Pathway in the Gram-Positive Facultative Methylotrophic Bacterium <i>Mycobacterium gastri</i> MB19 (2000)

A 4.2-kb PstI fragment harboring the gene cluster of the ribulose monophosphate (RuMP) pathway for formaldehyde fixation was identified in the chromosome of a gram-positive, facultative methylotroph, Mycobacterium gastri MB19, by using the coding region of 3-hexulose-6-phosphate synthase (HPS) as the hybridization probe. The PstI fragment contained three complete open reading frames (ORFs) which encoded from the 5' end, a DNA-binding regulatory protein (rmpR), 6-phospho-3-hexuloisomerase (PHI; rmpB), and HPS (rmpA). Sequence analysis suggested that rmpA and rmpB constitute an operon, and Northern blot analysis of RNA extracted from bacteria grown under various conditions suggested that the expression of the two genes is similarly regulated at the transcriptional level. A similarity search revealed that the proteins encoded by rmpA and rmpB in M. gastri MB19 show high similarity to the unidentified proteins of nonmethylotrophic prokaryotes, including bacteria and anaerobic archaea. The clusters in the phylogenetic tree of the HPS protein of M. gastri MB19 and those in the phylogenetic tree of the PHI protein were nearly identical, which implies that these two formaldehyde-fixing genes evolved as a pair. These findings give new insight into the acquisition of the formaldehyde fixation pathway during the evolution of diverse microorganisms.
Abstract 4327: Progranulin (GP88) is an independent prognostic factor for prostate cancer patients (2020)

Abstract Prostate cancer, is still a major cause of morbidity and mortality among men worldwide. The expression of the survival and proliferation factor progranulin (GP88) has not yet been comprehensively studied in PCa tumors. The aim of this study was to characterize GP88 protein expression in PCa by immunohistochemistry and to correlate the findings to the clinico-pathological data and prognosis. Immunohistochemical staining for GP88 was performed by TMA with samples from 442 PCa patients using an immunoreactive score (IRS). Altogether, 233 cases (52.7%) with negative GP88 staining (IRS&amp;lt;2) and 209 cases (47.3%) with positive GP88 staining (IRS≥2) were analyzed. A significant positive correlation was found for the GP88 IRS with the PSA value at prostatectomy and the cytoplasmic cytokeratin 20 IRS, whereas it was negatively associated with follow-up times. The association of GP88 staining with prognosis was further studied by survival analysis (Kaplan-Meier, univariate and multivariate Cox's regression analysis). Increased GP88 protein expression appeared as independent prognostic factor for overall, disease-specific and relapse-free survival in all PCa patients. Interestingly, in the subgroup of younger PCa patients (≤65 years), GP88 positivity was associated with a 3.8-fold (P=0.004), a 6.0-fold (P=0.008) and a 3.7-fold (P=0.003) increased risk for death, disease-specific death and occurrence of a relapse, respectively. This finding gains impact against the background of increasing numbers of PCa cases among younger men below 65 years of age. Summarizing, GP88 protein positivity appears to be an independent prognostic factor for PCa patients. Citation Format: Helge W. Taubert, Amer Abdulrahman, Markus Eckstein, Rudolf Jung, Juan Guzman, Katrin Weigelt, Ginette Serrero, Binbin Yue, Carol Geppert, Robert Stöhr, Arndt Hartmann, Bernd Wullich, Sven Wach. Progranulin (GP88) is an independent prognostic factor for prostate cancer patients [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 4327.
Synthesis of the Carbocyclic Core of Zoanthenol: Implementation of an Unusual Acid-Catalyzed Cyclization (2007)

A smokin' hot cyclization! When the racemic cyclization precursor is heated in neat trifluoroacetic acid, an unusual Friedel–Crafts-type cyclization forms the carbocyclic core of the marine alkaloid zoanthenol containing two all-carbon-substituted quaternary centers. Catalytic asymmetric alkylation allows entry into an enantioselective route. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700430_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Heart rate variability and QT interval in diabetes mellitus and their association with cardiac death. (1994)

糖尿病患者の心拍変動およびQT間隔と, 自律神経障害および心臓死との関連を検討した.対象は健常人13例 (C群) , 糖尿病群は自律神経障害を合併しない生存群9例 (AN (-) 群) , 自律神経障害を合併する生存群21例 (AN (+) 群) および心臓死群10例 (CD群) である.ホルター心電図より低周波数成分 (LF) , 高周波数成分 (HF) , LF/HFおよびRR間隔標準偏差の平均 (SD) を, 標準12誘導心電図よりQTc間隔およびQTc dispersion (最大QTcと最小QTcの差) を求めた.AN (+) 群とCD群は, C群に比しLF, HF, LF/HFおよびSDの24時間平均値と, その日内変動は著明に低下していた.最大QTc間隔はC群に比し糖尿病群では有意に延長していたが, 糖尿病の3群間には有意差を認めなかった.QTc dispersionはC群に比しCD群のみ有意に大であった.CD群は時間経過とともにHFの低下とQTc dispersionの増加が認められた.以上の成績から, 糖尿病患者の心臓死と自律神経障害およびQTc dispersionによって示される心室筋再分極の不均一性との関連が示唆された.
Toeplitz Inverse Covariance-Based Clustering of Multivariate Time Series\n Data (2017)

Subsequence clustering of multivariate time series is a useful tool for\ndiscovering repeated patterns in temporal data. Once these patterns have been\ndiscovered, seemingly complicated datasets can be interpreted as a temporal\nsequence of only a small number of states, or clusters. For example, raw sensor\ndata from a fitness-tracking application can be expressed as a timeline of a\nselect few actions (i.e., walking, sitting, running). However, discovering\nthese patterns is challenging because it requires simultaneous segmentation and\nclustering of the time series. Furthermore, interpreting the resulting clusters\nis difficult, especially when the data is high-dimensional. Here we propose a\nnew method of model-based clustering, which we call Toeplitz Inverse\nCovariance-based Clustering (TICC). Each cluster in the TICC method is defined\nby a correlation network, or Markov random field (MRF), characterizing the\ninterdependencies between different observations in a typical subsequence of\nthat cluster. Based on this graphical representation, TICC simultaneously\nsegments and clusters the time series data. We solve the TICC problem through\nalternating minimization, using a variation of the expectation maximization\n(EM) algorithm. We derive closed-form solutions to efficiently solve the two\nresulting subproblems in a scalable way, through dynamic programming and the\nalternating direction method of multipliers (ADMM), respectively. We validate\nour approach by comparing TICC to several state-of-the-art baselines in a\nseries of synthetic experiments, and we then demonstrate on an automobile\nsensor dataset how TICC can be used to learn interpretable clusters in\nreal-world scenarios.\n
Patients with B cell chronic lymphocytic leukaemia have an expanded population of CD4<sup>+</sup> perforin expressing T cells enriched for human cytomegalovirus specificity and an effector‐memory phenotype (2009)

We have previously shown an expansion of cytotoxic antigen-experienced CD4(+)T cells (CTLs) that express perforin (PF) in the peripheral blood of patients with B cell chronic lymphocytic leukaemia (B-CLL). Increased frequencies of CD4(+)CTLs have since been attributed to chronic viral infections, particularly, human cytomegalovirus (HCMV). The present study examined the involvement of CD4(+)CTLs in responses to HCMV in B-CLL, and characterized their differentiation. We studied 36 HCMV seropositive (SP) and seronegative B-CLL patients and 20 healthy age-matched individuals. The HCMV reactivity of CD4(+)PF(+) and CD4(+)PF(-) cells was determined by interferon-gamma expression, and expression of CD45RA and CCR7 was assessed by flow cytometry. Fluorescence in-situ hybridization was used to measure relative telomere lengths. CD4(+)PF(+)T cell expansion in B-CLL patients and controls was strongly associated with HCMV seropositivity. CD4(+)PF(+) compared to CD4(+)PF(-) cells from SP B-CLL patients elicited major histocompatibility complex (MHC) class II-restricted responses to HCMV. CD4(+)PF(+)T cells from patients and controls were enriched with highly differentiated T-effector/memory (CCR7(-)) and revertant (CCR7(-)CD45RA(+)) phenotype. CD4(+)PF(+)T cells from B-CLL patients had shorter telomeres than CD4(+)PF(-)T cells, indicating an extensive replicative history. We conclude that persistent exposure to HCMV antigens in SP B-CLL patients leads to an expansion of the circulating MHC class II-restricted CD4(+)PF(+)T cell population with effector/memory phenotype.
Um Compilador para a Linguagem Híbrida de Programação Paralela C_Actus (1993)

Neste trabalho é proposta uma nova versão da linguagem de programação paralela Actus, na qual é introduzido o conceito de modularização e modificações orientadas para uma maior simplicidade tanto no processo de compilação como na depuração de programas paralelos além de assegurar uma maior transportabilidade da linguagem para máquinas vetoriais e máquinas MIMD. A implementação do compilador da linguagem híbrida resultante, denominada C_Actus é discutida.
Adverse effects of very high-frequency sound and ultrasound on humans (2018)

For many years, workers have reported adverse symptoms resulting from exposure to very high-frequency sound (VHFS) and ultrasound (US), including annoyance, dizziness and difficulty concentrating. Recent work showing the presence of a new generation of VHFS/US sources in public places has reopened the debate about whether adverse effects can be caused by exposure to VHFS/US. Our field measurements of VHF/US sources in public places have identified devices producing up to 100 dB SPL at 20 kHz. Nearly all of the sources measured, including those in places occupied by tens of millions of people each year, are likely to be clearly audible to many young people. We have conducted two studies. The first looked at adverse symptoms resulting from exposure to audible VHFS/US, and the second was a double-blind study of adverse symptoms resulting from exposure to inaudible VHFS/US. In each study, both symptomatic participants, who reported previously experiencing symptoms, and asymptomatics participants, who did not, were tested. We found evidence that symptoms were produced by exposure to audible VHFS/US but not by inaudible sound. It is possible that the substantial effects reported for inaudible VHFS/US exposure were not reproduced because of ethical restrictions on stimulus level and duration.