gebhart/patrepeval huggingface dataset:
Predict Flexural Rigidity of Sandwich Structures Using Mechanical Properties of the Constituents (2009)

Abstract Recently, an advanced technique was developed to fabricate sandwich structures for high temperature applications by depositing alloy 625 skins on Ni alloy foam core by thermal spraying. This study tries to utilize an analytical model to estimate the mechanical performance of these structures based on the mechanical properties of the constituents. The mechanical behavior of the Ni alloy foam is assessed via compression testing, while tensile tests are used in the case of the alloy coating. The flexural rigidity of the sandwich structure is calculated using analytical models and experimentally obtained elastic moduli of the alloy 625 coating and Ni alloy foam. The model is also used to calculate the flexural rigidity of sandwich samples with different skin thicknesses to check the accuracy of the model and to understand the effect of skin thickness on the predicted mechanical performance of sandwich structures. The effect of heat treatment on the mechanical behavior of sandwich structures is investigated as well.
Influence of processing and material variables on resin‐fiber interface in liquid composite molding (1993)

Abstract In this study, systematic investigation of influence of processing variables on the tensile strength and resin‐fiber interface of composites prepared by liquid composite molding process was carried out. The variables studied included injection pressure and mold/fiber mat temperature. Fibers were better wetted and bonded at lower injection pressure and higher molding temperature, which resulted in a higher tensile strength of molded composites. Single filament composite tests were also used in conjunction with birefringence studies to characterize interface bonding. Improved interfacial behavior was observed in the case of compatible systems.
Proceedings of the Emerging M&S Applications in Industry & Academia / Modeling and Humanities Symposium (2013)

Welcome to the Spring Simulation Multi-Conference 2013 (SpringSim'13) in San Diego, CA. As the General Chair of this year's SpringSim, it is an honor and privilege to be your host for these exciting four days of activities driven and organized by the various members of our society. Despite challenges in the worldwide economy and the overall decrease of funding for travel and conferences, the interest in Modeling and Simulation (M&S) and its applications is still high enough to ensure a challenging and interesting program. From the opening tutorial day where international experts are providing their knowledge to our community to the presentation of peer-reviewed papers, invited special topic presentations, and expert panel discussions the chairs of our symposia did their best to provide an outstanding choice. Without the work of these volunteers, SpringSim would not have been possible.
Developmental processes and the induction of cardiovascular function: conceptual aspects (2005)

The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider biological nature of the phenomenon, with particular reference to 'maternal effects', the processes observed in many species by which the mother can induce phenotypic effects in her offspring. Animal models permit investigation of the induction of cardiovascular phenotypic attributes which resemble pathological effects in humans. We discuss the importance of transitions in aspects of the pre- versus the postnatal environment, with emphasis on nutrition and energy expenditure, and the critical role which the timing of environmental cues plays in inducing effects on the offspring. Coupled with the effects of specific maternal dietary components, the effects on the offspring are argued to involve epigenetic mechanisms. In this review we provide a conceptual framework for synthesising experimental and clinical data, important for considering the impact of the developmental origins concept in a life-course approach to the prevention of cardiovascular disease.
Supplementary Table S2 from High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers (2023)

&lt;p&gt;TNBC and non-TNBC cell line subtype, cell cycle and SAC characteristics and BOS172722 potency.&lt;/p&gt;
On Capacity and Bounds for the Gaussian CZIC and CBZIC with Linear Coded Approximation (2013)

In this paper, we study the Gaussian Cognitive Zinterference channel (GCZIC) and its multiuser extension the Gaussian Cognitive Z-broadcast interference channel (GBZIC). We review some known capacity results and bounds for the GCZIC for various levels of interference. We derive a new improved inner bound for the CZIC under conditions which intersect with those for which the capacity is not known. Then we derive the capacity results and bounds for the CBZIC when the broadcast component of the channel is a degraded broadcast&#13;\nchannel.
Debris measurement at the intermediate focus of a laser-assisted discharge-produced plasma light source (2010)

For extreme ultraviolet light lithography to be a viable process for the future development of computer chips, it is necessary that clean photons are produced at the intermediate focus (IF). To measure the flux at the IF, the Center for Plasma-Material Interactiosn (CPMI) at the University of Illinois at Urbana-Champaign has developed a Sn IF flux emission detector (SNIFFED) apparatus that is capable of measuring charged and neutral particle flux at the IF. Results will be presented that diagnose debris produced at the IF, as well as methods by which this debris can be mitigated. Advanced Materials Research Center, AMRC, International SEMATECH Manufacturing Initiative, and ISMI are servicemarks of SEMATECH, Inc. SEMATECH, and the SEMATECH logo are registered servicemarks of SEMATECH, Inc. All other servicemarks and trademarks are the property of their respective owners.
Supplementary Figures 6-10 from Ploidy and Large-Scale Genomic Instability Consistently Identify Basal-like Breast Carcinomas with &lt;i&gt;BRCA1/2&lt;/i&gt; Inactivation (2023)

&lt;p&gt;PDF file - 511K, Figure S6. Persistence and robustness of the discriminating �window� independently of the method of LSTs evalutation (supplementary to Figure 2B). Figure S7. Two tumors with similar total numbers of breakpoints. Figure S8. Distribution of LSTs along the genome, GC content and common fragile site for the chromosome bands with LSTs detected in more than 6 tumors. Figure S9. Somatic mutation in BRCA1 detected in two BLCs. Figure S10. LSTs in xenograft passages from GSE32530.&lt;/p&gt;
Bringing upconversion down to the molecular scale (2018)

After solid state and nanoparticles, discrete molecular and supramolecular systems displaying upconversion (UC) in solution have recently emerged in the literature. This frontier article intends to recall the roots of molecular UC and will try to draw perspectives to improve the actual state of the art.
Microchemical enantioseparation of betaxolol and orciprenaline by reversed phase HPLC (2020)

Abstract Enantioseparation of ( RS )‐orciprenaline and ( RS )‐betaxolol was achieved by synthesizing their diastereomeric derivatives with chiral derivatizing reagents prepared on a cyanuric chloride platform. There were three dichloro‐triazine derivatives with amino acid amides as chiral auxiliaries and three monochloro‐triazine derivatives with methoxy as achiral moiety and amino acid amides as chiral auxiliaries in cyanuric chloride. A total of 12 pairs of diastereomeric derivatives were synthesized under microwave irradiation and were separated using reversed phase high‐performance liquid chromatography by applying different mobile phases on a C 18 column in gradient eluting mode with ultraviolet detection at 230 nm. Resolutions were compared and interpreted on the basis of structure of chiral auxiliaries. Besides, diastereomeric derivatives were separated by open column chromatography and the samples so obtained were used for confirmation of their elution order and configuration by 1 H‐NMR spectroscopy. In addition, lowest energy optimized structures of diastereomeric derivatives were developed using the density functional theory based Gaussian software that were interpreted to supplement the absolute configurations. The method validation was carried out for detection limit, linearity, accuracy, and precision. Limits of detection were 0.005 and 0.007 µg/mL.
Cellular and humoral immune responses induced in cattle by vaccination with Babesia divergens culture-derived exoantigens correlate with protection (1993)

Previous results with the Babesia divergens gerbil vaccination model were extended in studies with cattle. Two calves were vaccinated with culture-derived B. divergens exoantigens, and two others were treated with control supernatant; both preparations were adjuvanted with Quil-A saponin. A parasite-specific humoral response was observed after the first vaccine injection and was boosted by two succeeding vaccine injections. Sera from the two vaccinated calves immunoprecipitated eight major parasitic proteins (with molecular masses ranging between 17 and 110 kDa) whose patterns were close to those observed in gerbil vaccine assays. The cellular immune response, monitored by lymphoproliferation assays, was slightly delayed in comparison with the humoral response; a significant proliferation occurred only after the second vaccine injection. Mononuclear cell proliferation was dose dependent in the presence of (i) lysates of B. divergens-parasitized erythrocytes, (ii) exoantigens of the whole supernatant, or (iii) protective exoantigens of two low-molecular-mass fractions obtained after supernatant gel filtration chromatography. An infectious challenge was administered 3 weeks after the third vaccine injection, with 3.6 x 10(10) B. divergens-parasitized erythrocytes. Erythrocyte count, rectal temperature, and parasitemia of the animals were monitored daily until they returned to initial values. All parameters indicated that the exoantigens induced protection from B. divergens infection for the two vaccinated calves.
ChemInform Abstract: CHEMISTRY OF GEM‐DIHALOCYCLOPROPANES. XVII. CYCLOPROPYLIDENE INSERTION. FORMATION AND RING OPENING OF BICYCLO(1.1.0)BUTAN‐2‐OLATE (1983)

Abstract Reaktion der gem‐Dibromcyclopropane (Ia)‐(Ic) bzw. (Ie) mit Methyl‐Li führt zu allenischen Alkoholen (II) und im Falle von (Ia)‐(Ic) zu den Carbinolen (III) bzw. im Falle von (Ie) zu den Aldehyden (IVb) + (IVc); ein analoger Aldehyd (IVa) entsteht auch aus (Ic) [die Prozentangaben in Klammern bezeichnen den Produktanteil (Ausb.‐Angaben in g)].
CD4+ T cell restoration and control of hepatitis C virus replication after childbirth (2020)

Chronic hepatitis C virus (HCV) infection is characterized by persistent high-level viremia and defective cellular immunity, including a lack of functional HCV-specific CD4+ T cells. We previously described an exceptional period of viral control that occurs in some chronically infected women after childbirth. Here, we investigated whether reduced HCV replication after pregnancy is associated with recovery of CD4+ T cell immunity. Class II tetramer analysis revealed significantly greater frequencies of circulating HCV-specific CD4+ T cells at 3 months postpartum in women with concurrent declines in viremia compared with those with stable viremia. These HCV-specific CD4+ T cells had an effector-memory phenotype. Inhibitory coreceptor expression on these cells corresponded to the degree of viral control. Circulating CD4+ T cells produced IL-2 and IFN-γ after HCV antigen stimulation, demonstrating Th1 functionality. These data provide direct evidence that the profound loss of HCV-specific CD4+ T cell help that results in chronic infection is reversible following pregnancy, and this recovery of CD4+ T cells is associated with at least transient control of persistent viral replication.
Population attributable risk for colorectal and breast cancer in England, Wales, Scotland, Northern Ireland, and the United Kingdom (2022)

Up to 67% for CRC and 27% of BC were attributable to modifiable dietary and lifestyle factors in the UK. Moderate differences in PAR are observed between countries due to different prevalence of exposure to risk factors.
Comprehensive Genomic Profiling of Recurrent Classic Glioblastoma in a Patient Surviving Eleven Years Following Antineoplaston Therapy (2015)

Most patients with recurrent glioblastoma (RGBM) die within 6 months regardless of treatment. In phase II studies of Antineoplaston A10 and AS2-1 injections (ANP), our investigators have reported objective responses and long-term survival in RGBM. Using a next-generation sequencing (NGS) based assay of 343 cancer-related genes and introns, comprehensive genomic profiling of tumor tissue obtained from a RGBM patient (who remains alive and well) was performed 11 years after diagnosis and permitted assignment of the patient’s RGBM to the classical subgroup. The most important genomic alterations included amplification of epidermal growth factor receptor (EGFR), cyclin-dependent kinase inhibitor 2A and 2B (CDKN2A/B), loss of phosphatase and tensin homolog (PTEN) and telomerase reverse transcriptase (TERT) mutation. An analysis of the signaling networks and other targets of ANP therapy was recently performed and presented in this publication. Based on our findings, patients with classical RGBM have a reasonable possibility of responding to ANP therapy and experiencing long-term survival. It is proposed that this subgroup of RGBM patients be enrolled in a genomics-driven clinical trial of ANP therapy.
Physical Fitness Components And Cortical And Subcortical Brain Volume In Overweight/obese Children (2017)

PURPOSE: To examine the association between the key components of physical fitness (i.e. cardiorespiratory fitness, speed-agility and muscular fitness) and brain structural volume in overweight/obese children. METHODS: A total of 101 overweight/obese children aged 8-11 years were recruited from Granada, Spain. The physical fitness components were assessed following the ALPHA health-related fitness test battery. T1-weighted images were acquired with a 3.0 Tesla Siemens Magnetom Tim Trio system. Gray matter tissue was calculated using Diffeomorphic Anatomical Registration Through Exponentiated Lie algebra (DARTEL). All analyses were controlled for sex, peak high velocity offset, parent education, body mass index and total brain volume. The statistical threshold was calculated with AlphaSim and further Hayasaka adjusted to account for the non-isotropic smoothness of structural images. RESULTS: Cardiorespiratory fitness was related to greater gray matter volumes (P< 0.001, k=58) in 9 out of all regions with β ranging from 0.493 to 0.584; specifically in frontal regions (i.e. premotor cortex and medial primary motor cortex), superior parietal cortex, subcortical regions (i.e. hippocampus and caudate), temporal regions (i.e. middle and inferior temporal gyri and parahippocampal gyrus) and calcarine cortex. Speed-agility was associated with greater gray matter volumes (P< 0.001, k=54) in 2 regions (i.e. the inferior frontal gyrus and the superior temporal gyrus) with β ranging from 0.564 to 0.611. Muscular fitness was not independently associated with greater gray matter volume in any brain regions. No brain regions showed statistically significant negative associations between components of physical fitness and gray matter volume. CONCLUSIONS: Cardiorespiratory fitness and speed-agility, but not muscular fitness, might independently be associated with greater volume of numerous cortical and subcortical brain structures. Importantly, those associated brain structures are different for each fitness component. These findings suggest that the development of cardiorespiratory fitness and speed-agility might positively affect development of distinctive brain regions and contribute to counteract the harmful effect of overweight and obesity on brain structure during childhood.
Model predictive control for wind turbine load reduction under wake meandering of upstream wind turbines (2012)

In wind farm operation, the performance and loads of downstream turbines are heavily influenced by the wake of the upstream turbines. Furthermore, the actual wake is more challenging due to the dynamic phenomenon of wake meandering, i.e. the turbine wake often demonstrates dynamic shift over time. To deal with the time-varying characteristics of wake meandering, the dual-mode linear quadratic model predictive control (LQMPC) scheme is applied to the individual pitch control (IPC) based load reduction. The coherence function along the lateral direction in the spectral method is used to generate the stochastic wind profile including wake meandering at upstream turbine, and a simplified wake meandering model is developed to emulate the trajectory of the wake center at downstream turbine. The Larsen wake model and Gaussian distribution of wake deficit are applied for composing wind profiles across the rotor of downstream turbines. State-space models are derived via the Blade Element Momentum (BEM) theory. A set of MPC controllers are designed based on different linearized state-space models, and are applied in a switching manner. Simulation results show the reduction in the blade-root flapwise moment and the rotor speed variation.
High sensitivity imaging of resin-rich regions in graphite/epoxy laminates using joint entropy (2014)

The continuing difficulty of detecting critical flaws in advanced materials requires novel approaches that enhance sensitivity to defects that might impact performance. This study compares different approaches for imaging a near-surface resin-rich defect in a thin graphite/epoxy plate using backscattered ultrasound. The specimen, having a resin-rich void immediately below the top surface ply, was scanned with a 1 in. dia., 5 MHz center frequency, and 4 in. focal length transducer. A computer controlled apparatus comprised of an x-y-z motion controller, a digitizer (LeCroy 9400A), and an ultrasonic pulser/receiver (Panametrics 5800) was used to acquire data on a 100 ×100 grid of points covering a 3 × 3 in. square. At each grid point 256 512-word, 8-bit backscattered waveforms, were digitized, signal averaged, and then stored on computer for off-line analysis. The same backscattered waveforms were used to produce peak-to-peak, signal energy, as well as entropy images. All of the entropy images exhibit better border delineation and defect contrast than the either peak-to-peak or signal energy. The best results are obtained using the joint entropy of the backscattered waveforms with a reference function. Two different references are examined: a reflection from a stainless steel reflector, and an approximate optimum obtained from an iterative parametric search. The joint entropy images produced using the optimum reference exhibit ~3 times the contrast obtained in previous studies.
Single Step Purification of a Small Non-mAb Biologic by Peptide-ELP based Affinity Precipitation (2020)

Affinity precipitation using stimulus-responsive biopolymers such as Elastin-like Polypeptides (ELPs) have been successfully employed for the purification of monoclonal antibodies. In the current work, we extend these studies to the development of an ELP-peptide fusion for the affinity precipitation of the therapeutically relevant small non-mAb biologic, AdP. A 12-mer affinity peptide ligand (P10) was identified by a primary phage biopanning followed by a secondary in-solution fluorescence polarization screen. Peptide P10 and AdP interacted with a KD of 19.5 µM. A fusion of P10 with ELP was then shown to be successful in selectively capturing the biologic from a crude mixture. While pH shifts alone were not sufficient for product elution, the use of pH in concert with fluid phase modifiers such as NaCl, arginine or ethylene glycol was successful. In particular, the use of pH 8.5 and an arginine concentration of 500 mM enabled > 80% product recovery. The overall process performance evaluated by SDS-PAGE and reversed-phase UPLC analyses, indicated the successful single-step purification of the biologic from an E. coli lysate resulting in ~90% purity and >80% recovery. These results demonstrate that phage display can be readily employed to identify a peptide ligand capable of successfully carrying out the purification of a non-antibody biological product using ELP-based affinity precipitation.
Editorial Comment (2016)

No AccessJournal of UrologyAdult Urology1 Apr 2016Editorial Comment Mathew D. Sorensen Mathew D. SorensenMathew D. Sorensen More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2015.10.191AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Editorial Comment." The Journal of Urology, 195(4 Part 1), p. 970 © 2016 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 195Issue 4 Part 1April 2016Page: 970 Advertisement Copyright & Permissions© 2016 by American Urological Association Education and Research, Inc.MetricsAuthor Information Mathew D. Sorensen More articles by this author Expand All Advertisement PDF downloadLoading ...
Synthesis of an Iridoid-Inspired Compound Collection and Discovery of Autophagy Inhibitors (2016)

Iridoids comprise a large group of monoterpenoid natural products displaying a diverse array of biological activities ranging from neurotrophic to anti-inflammatory and anti-tumorigenic properties. Therefore, the development of concise synthesis routes to compound collections inspired by the structural features of these natural products is of particular relevance for chemical biology and medicinal chemistry. Herein we describe a samarium diiodide-mediated synthesis of a small, focused iridoid-inspired compound collection. Characterization of these iridoid analogues in biological assays revealed novel small-molecule inhibitors of autophagy.
Genome-Wide Expression Profiling and Mutagenesis Studies Reveal that Lipopolysaccharide Responsiveness Appears To Be Absolutely Dependent on TLR4 and MD-2 Expression and Is Dependent upon Intermolecular Ionic Interactions (2011)

Lipid A (a hexaacylated 1,4' bisphosphate) is a potent immune stimulant for TLR4/MD-2. Upon lipid A ligation, the TLR4/MD-2 complex dimerizes and initiates signal transduction. Historically, studies also suggested the existence of TLR4/MD-2-independent LPS signaling. In this article, we define the role of TLR4 and MD-2 in LPS signaling by using genome-wide expression profiling in TLR4- and MD-2-deficient macrophages after stimulation with peptidoglycan-free LPS and synthetic Escherichia coli lipid A. Of the 1396 genes significantly induced or repressed by any one of the treatments in the wild-type macrophages, none was present in the TLR4- or MD-2-deficient macrophages, confirming that the TLR4/MD-2 complex is the only receptor for endotoxin and that both are required for responses to LPS. Using a molecular genetics approach, we investigated the mechanism of TLR4/MD-2 activation by combining the known crystal structure of TLR4/MD-2 with computer modeling. According to our murine TLR4/MD-2-activation model, the two phosphates on lipid A were predicted to interact extensively with the two positively charged patches on mouse TLR4. When either positive patch was abolished by mutagenesis into Ala, the responses to LPS and lipid A were nearly abrogated. However, the MyD88-dependent and -independent pathways were impaired to the same extent, indicating that the adjuvant activity of monophosphorylated lipid A most likely arises from its decreased potential to induce an active receptor complex and not more downstream signaling events. Hence, we concluded that ionic interactions between lipid A and TLR4 are essential for optimal LPS receptor activation.