gebhart/patrepeval huggingface dataset:
Evidence and Characterization of a New Decamolybdocobaltate Cobalt Salt:  An Efficient Precursor for Hydrotreatment Catalyst Preparation (2005)

Heteropolyanions (HPAs) based on molybdenum and cobalt could be used as an alternative to the conventional ammonium heptamolybdate and cobalt nitrate precursors for the preparation of Co−Mo/Al2O3 hydrotreating catalysts. With this objective in mind, a cobalt salt of decamolybdocobaltate anion has been synthesized. This salt allows us to prepare catalyst with a Co/Mo atomic ratio of 0.5 corresponding to the optimum value encountered with classical catalyst preparation. The crystal structure refinement has been performed and reveals the formation of a new heteropolyoxomolybdate related to the well-known Anderson structure. Its structural, spectroscopic, and thermal properties have been investigated by physical techniques such as thermogravimetric analysis mass spectroscopy, X-ray diffraction, X-ray absorption spectroscopy, and vibrational spectroscopy. With the use of this new HPA precursor, initial catalytic results show a significant improvement of hydrodesulfurization catalytic performance.
ChemInform Abstract: New Cyanoglycosides, Hydracyanosides D, E, and F, from the Leaves of Hydrangea macrophylla. (2010)

Abstract Together with 17 known compounds, three new cyanoglycosides named hydracyanosides D (I), E (II), and F (III) are isolated from the leaves of Hydrangea macrophylla cultivated in China.
Negative induction effect of graphite N on graphene quantum dots: tunable band gap photoluminescence (2015)

We synthesized nitrogen-doped graphene quantum dots (N-GQDs) under a high temperature range of 800–1200 °C and high pressure of 4.0 GPa through a solid-to-solid process.
10-Gb/s All-Optical Half-Adder With Interferometric SOA Gates (2004)

In this letter, we report an all-optical module that generates simultaneously four Boolean operations at 10 Gb/s. The circuit employs two cascaded ultrafast nonlinear interferometers and requires only two signals as inputs. The first gate is configured as a 2 /spl times/ 2 exchange-bypass switch and provides OR and AND logical operations. The second gate generates XOR (SUM bit) and AND (CARRY bit) Boolean operations and constitutes a binary half-adder. Successful operation of the system is demonstrated with 10-Gb/s return-to-zero pseudorandom data patterns.
Achieving robust average consensus over wireless networks (2016)

This work addresses the average consensus problem over wireless networks that suffer from transmitter-based random communication losses. Two novel methods are proposed to compensate for the information that is lost during communication as a result of packet collisions. The speeds of convergence of the two methods are analytically estimated and compared with another compensation method from the literature: simulations illustrate and validate our results. Furthermore, we describe a time-slotted communication algorithm to implement the compensation methods.
BLADE (2010)

Web-based surreptitious malware infections (i.e., drive-by downloads) have become the primary method used to deliver malicious software onto computers across the Internet. To address this threat, we present a browser independent operating system kernel extension designed to eliminate driveby malware installations. The BLADE (Block All Drive-by download Exploits) system asserts that all executable files delivered through browser downloads must result from explicit user consent and transparently redirects every unconsented browser download into a nonexecutable secure zone of disk. BLADE thwarts the ability of browser-based exploits to surreptitiously download and execute malicious content by remapping to the file system only those browser downloads to which a programmatically inferred user-consent is correlated, BLADE provides its protection without explicit knowledge of any exploits and is thus resilient against code obfuscation and zero-day threats that directly contribute to the pervasiveness of today's drive-by malware. We present the design of our BLADE prototype implementation for the Microsoft Windows platform, and report results from as extensive empirical evaluation of its effectiveness on popular browsers. Our evaluation includes multiple versions of IE and Firefox, against 1,934 active malicious URLs, representing a broad spectrum of web-based exploits not plaguing the Internet. BLADE successfully blocked all drive-by malware install attempts with zero false positives and a 3% worst-case performance cost.
Accurate real-time sensing tip for aqueous NO with optical fibers embedded in active hydrogel waveguide (2018)

A NO sensing tip is made by inserting two parallel optical fibers inside a poly 2-hydroxyethyl methacrylate (PolyHEMA) hydrogel waveguide mixed with the probe molecule 1, 2-Diaminoanthraquinone (DAQ). There is a length difference of 1 mm between the two fibers, and the light has to propagate through the difference from the short fiber to the long fiber. The total cross section area of the active hydrogel waveguide embedded with the fibers is only 3mm x 1.2 mm. For practical use the tip is housed in a needle for mechanical protection and the sensing tip is able to detect aqueous NO concentration around 1 μM with time resolution about 5 minutes. Such a sensing tip can be used to monitor the medical conditions inside the brain after a stroke or a brain injury.
Thermoelastic properties of ReB2 at high pressures and temperatures and comparison with Pt, Os, and Re (2011)

We have measured the phase stability and thermoelastic equation of state of ultrahard rhenium diboride at pressures up to 30 GPa and temperatures up to 2500 K using a laser heated diamond anvil cell in conjunction with synchrotron X-ray diffraction. ReB2 is shown to be stable throughout this pressure and temperature region. The ratio of the c-axis to the a-axis provides a monitor of the annealing of plastic stresses during compression. We show that ReB2 has a small thermal anisotropy but a large mechanical anisotropy. Combining this new data set with previously existing results from a large volume press yields a thermoelastic equation of state with a Grüneisen parameter of 2.4 (0.08) and a q of 2.7. A comparison of ReB2 with other high electron density incompressible metals—Os, Re, and Pt—shows that ReB2 has the lowest thermal pressure and the highest bulk modulus.
Increasing Polycrystalline Zinc Oxide Grain Size by Control of Film Preferential Orientation (2015)

We investigate the structural evolution of polycrystalline zinc oxide films grown by low pressure metal–organic chemical vapor deposition. The goal is to achieve larger grains—leading to higher charge carrier mobility from lower grain boundary density—by controlling the grain orientation during growth. The results are 2-fold. First we describe how the combination of deposition temperature and gas flow influences the nucleation and film thickening stages: low temperature and high gas flow favor a high nucleation density and the development of c-textured films, whereas high temperature and low gas flow lead to a lower nucleation density and a-textured films. Second we demonstrate how a fine control of the film preferential orientation at the different growth stages allows the fabrication of films with grains that are 25% larger, hence improving the carrier mobility with respect to the reference film.
Real-Time Monitoring of a Protein Biomarker (2020)

The ability to monitor protein biomarkers continuously and in real-time would significantly advance the precision of medicine. Current protein-detection techniques, however, including ELISA and lateral flow assays, provide only time-delayed, single-time-point measurements, limiting their ability to guide prompt responses to rapidly evolving, life-threatening conditions. In response, here we present an electrochemical aptamer-based sensor (EAB) that supports high-frequency, real-time biomarker measurements. Specifically, we have developed an electrochemical, aptamer-based (EAB) sensor against Neutrophil Gelatinase-Associated Lipocalin (NGAL), a protein that, if present in urine at levels above a threshold value, is indicative of acute renal/kidney injury (AKI). When deployed inside a urinary catheter, the resulting reagentless, wash-free sensor supports real-time, high-frequency monitoring of clinically relevant NGAL concentrations over the course of hours. By providing an "early warning system", the ability to measure levels of diagnostically relevant proteins such as NGAL in real-time could fundamentally change how we detect, monitor, and treat many important diseases.
A Network of Genetic Events Sufficient to Convert Normal Human Cells to a Tumorigenic State (2005)

Although great progress has been made at identifying and characterizing individual genes involved in cancer, less is known about how the combination of such genes collaborate to form tumors in humans. To this end, we sought to genetically recreate tumorigenesis in normal human cells using genes altered in human cancer. We now show that expression of mammalian proteins that inactivate the tumor suppressors Rb and p53 in conjunction with the oncoproteins Ras and Myc and the telomerase subunit hTERT is sufficient to drive a number of normal human somatic cells to a tumorigenic fate. This provides a blueprint of the events that lead to human cancer, allowing different cancers to be genetically modeled from normal human cells.
Materials Screening for the Discovery of New Half-Heuslers: Machine Learning versus Ab Initio Methods (2017)

Machine learning (ML) is increasingly becoming a helpful tool in the search for novel functional compounds. Here we use classification via random forests to predict the stability of half-Heusler (HH) compounds, using only experimentally reported compounds as a training set. Cross-validation yields an excellent agreement between the fraction of compounds classified as stable and the actual fraction of truly stable compounds in the ICSD. The ML model is then employed to screen 71,178 different 1:1:1 compositions, yielding 481 likely stable candidates. The predicted stability of HH compounds from three previous high throughput ab initio studies is critically analyzed from the perspective of the alternative ML approach. The incomplete consistency among the three separate ab initio studies and between them and the ML predictions suggests that additional factors beyond those considered by ab initio phase stability calculations might be determinant to the stability of the compounds. Such factors can include configurational entropies and quasiharmonic contributions.
Quantum information sharing between topologically distinct platforms (2016)

Can topological quantum entanglement between anyons in one topological medium ``stray'' into a different, topologically distinct medium? In other words, can quantum information encoded nonlocally in the combined state of non-Abelian anyons be shared between two distinct topological media? For one-dimensional topological superconductors with Majorana bound states at the end of system, the quantum information store in those Majorana bound states can be transfered by directly coupling nearby Majorana bound states. However, coupling of two one-dimensional Majorana states will produce a gap, indicating that distinct topological regions of one-dimensional wires unite into a single topological region through the information transfer process. In this paper, we consider a setup with two two-dimensional $p$-wave superconductors of opposite chirality adjacent to each other. Even two comoving chiral modes at the domain wall between them cannot be gapped through interactions; we demonstrate that information encoded in the fermionic parity of two Majorana zero modes, originally within the same superconducting domain, can be shared between the domains or moved entirely from one domain to another provided that vortices can tunnel between them in a controlled fashion.
Slow and steadywins the race? energy consumption analysis of an EV competition (2014)

Electric vehicle competitions have been organized in order to test the limits of technology. In this paper, we describe a competition for students and the public. The competition was held in Lappeenranta in 2013. We also analyze what kinds of vehicles were used and what the winning strategy was.
Supplementary Figure 4 from Baseline Biomarkers for Outcome of Melanoma Patients Treated with Pembrolizumab (2023)

&lt;p&gt;Alternative combination models according for the relative impact of LDH, REC, RLC and the pattern of visceral metastasis. A nomogram was developed using the nomogram function of R (A). For each patient a linear predictor score (risk score) considering the relative impact of four single factors was calculated as follows: LDH-ratio &gt;2.5 - 100 points; presence of visceral metastasis other than lung - 96 points; REC &lt;1.5% - 69 points; RLC &lt;17.5% - 68 points. Thus, the resulting risk score (RS) ranges between 0 and 333 points. Kaplan-Meier analysis of overall survival is presented for 5 different combination models according to different risk score category definitions (B - E). Censoring is indicated by vertical lines. The discriminatory abilities (c-indices) for the respective models were 0.780 (B), 0.779 (C), 0.782 (D), 0.785 (E), and 0.781 (F).&lt;/p&gt;
Deficiency Of JAGN1 Causes Severe Congenital Neutropenia Associated With Defective Secretory Pathway and Aberrant Myeloid Cell Homeostasis (2013)

Abstract Analysis of patients with severe congenital neutropenia (SCN) may shed light on the delicate balance of factors controlling differentiation, maintenance, and decay of neutrophil granulocytes. Mutations in ELANE, GFI1, HAX1, G6PC3, WAS, and VPS45 are known to cause SCN. We here describe a new monogenetic SCN variant with biallelic mutations in the gene encoding Jagunal homolog 1 (JAGN1). We studied an index family from Northern Africa with a total of 5 children suffering from SCN. An Affymetrix SNP array-based genetic linkage analysis was performed and identified a single interval of perfect segregation with highly significant multi-marker LOD scores of at least 4.5spanning approximately 1.5Mbp from 9.52Mb to 11.04Mb on chromosome 3 of NCBI’s human genome build 36.3. This interval contained a total of 30 genes, including JAGN1 which encodes an ER-resident protein. Sanger sequencing revealed a homozygous mutation c.3G&gt;A in exon 1 of the JAGN1 gene; this mutation leads to disruption of the defined start of translation. Systematic analysis of a cohort of 90 SCN patients identified 9 distinct homozygous mutations in the gene encoding Jagunal homolog 1 (JAGN1) in 14 SCN patients, thus accounting for approximately 10% of SCN patients. The clinical phenotype was variable and included failure to thrive, developmental delay and bone skeletal abnormalities. The only consistent finding in all JAGN1-deficient patients was SCN and partial or complete refractoriness to therapy with rh-GCSF. JAGN1 is the human ortholog of a gene originally identified in Drosophila melanogaster. Jagunal-deficient oocytes are characterized by defective ER reorganization and aberrant membrane trafficking during vitellogenesis. We found that JAGN1-mutant human granulocytes showed aberrantly enlarged ER structures and paucity of secretory vesicles. We hypothesized that that ER aberrations may be associated with defective N-glycosylation of multiple proteins in neutrophil granulocytes and found that JAGN1-mutant neutrophil granulocytes exhibited anomalous N-glycomic profiles characterized by a marked reduction in fucosylation of all their multi-antennary glycans. JAGN1-deficient neutrophil granulocytes showed increased apoptosis in response to TNFa and staurosporine, likely accounting for the lack of mature neutrophils in these patients. Additional studies in JAGN1-knockdown cells indicate that JAGN1 participates in the secretory pathway and is required for granulocyte-colony stimulating factor receptor-mediated signaling. Global proteomic analysis of the JAGN1-interactome identified a limited number of interaction partners including members of the Coat Protein I (COPI) complex (COPA, COPB2, and COPG2) which suggest a role for JAGN1 in vesicular trafficking from Golgi to ER. Taken together, JAGN1 emerges as a hitherto unrecognized factor necessary in differentiation and survival of neutrophil granulocytes and a novel gene implicated in SCN. Disclosures: No relevant conflicts of interest to declare.
Inflatable antenna for cubesat: fabrication, deployment and results of experimental tests (2014)

CubeSats and small satellites have potential to provide means to explore space and to perform science in a more affordable way. As the goals for these spacecraft become more ambitious in space exploration, moving from Low Earth Orbit (LEO) to Geostationary Earth Orbit (GEO) or further, the communication systems currently implemented will not be able to support those missions. One of the bottlenecks is the antennas' size, due to the close relation between antenna gain and dimensions. Current antennas for CubeSats are mostly dipole or patch antennas with limited gain. Deployable (not inflatable) antennas for CubeSats are currently being investigated, but these solutions are affected by the challenge of packaging the whole deployable structure in a small spacecraft. The work that we propose represents the first attempt to develop an inflatable antenna for CubeSats. Inflatable structures and antennas can be packaged efficiently, occupying a small amount of space, and they can provide, once deployed, large dish dimension and correspondent gain. Inflatable antennas have been previously tested in space (Inflatable Antenna Experiment, STS-77). However they have never been developed for small spacecraft such as CubeSats, where the packaging efficiency, the deployment, and the inflation represent a challenge. Previous works developed by the authors described trade-off analysis, preliminary design and radiation model for the antenna. The research presented in this paper is focused specifically on implementation and testing. Details of the antenna's fabrication and related issues are illustrated as well as the mechanism to fold and deploy the antenna in space. Finally, results of the experimental tests (vacuum chamber and anechoic chamber) are described. Future work in the development of the antenna will include the improvement of the fabrication process and the design of a 3U CubeSat mission to be proposed as a technical demonstration.
Characterization of anthocyanins in wild Lycium ruthenicum Murray by HPLC-DAD/QTOF-MS/MS (2015)

<italic>L. ruthenicum</italic>, which grows mainly in the salinized desert of the Qinghai-Tibet plateau, contains abundant anthocyanins.
Improving Visual Accessibility for Color Vision Deficiency Based on MPEG-21 (2004)

In this paper, we propose a visual accessibility technique in an MPEG-21 framework. In particular, MPEG-21 visual accessibility for the colored-visual resource of a digital item is proposed to give better accessibility of color information to people with color vision deficiency (CVD). We propose an adaptation system for CVD as well as a description of CVD in MPEG-21. To verify the usefulness of the proposed method, computer simulations with CVD and color adaptation were performed. Furthermore, a statistical experiment was performed using volunteers with CVD in order to verify the effectiveness of the proposed visual accessibility technique in MPEG-21. Both the experimental and simulation results show that the proposed adaptations technique can provide better color information, particularly to people with CVD.
Kinetics of γH2AX and phospho-histone H3 following pulse treatment of TK6 cells provides insights into clastogenic activity (2021)

The desire for in vitro genotoxicity assays to provide higher information content, especially regarding chemicals' predominant genotoxic mode of action, has led to the development of a novel multiplexed assay available under the trade name MultiFlow®. We report here on an experimental design variation that provides further insight into clastogens' genotoxic activity. First, the standard MultiFlow DNA Damage Assay-p53, γ H2AX, phospho-histone H3 was used with human TK6 lymphoblastoid cells that were exposed for 24 continuous hours to each of 50 reference clastogens. This initial analysis correctly identified 48/50 compounds as clastogenic. These 48 compounds were then evaluated using a short-term, 'pulse' treatment protocol whereby cells were exposed to test chemical for 4 h, a centrifugation/washout step was performed, and cells were allowed to recover for 20 h. MultiFlow analyses were accomplished at 4 and 24 h. The γ H2AX and phospho-histone H3 biomarkers were found to exhibit distinct differences in terms of their persistence across chemical classes. Unsupervised hierarchical clustering analysis identified three groups. Examination of the compounds within these groups showed one cluster primarily consisting of alkylators that directly target DNA. The other two groups were dominated by non-DNA alkylators and included anti-metabolites, oxidative stress inducers and chemicals that inhibit DNA-processing enzymes. These results are encouraging, as they suggest that a simple follow-up test for in vitro clastogens provides mechanistic insights into their genotoxic activity. This type of information will contribute to improve decision-making and help guide further testing.
Electron Affinity (2016)

This document contains recommendations for terminology in mass spectrometry. Development of standard terms dates back to 1974 when the IUPAC Commission on Analytical Nomenclature issued recommendations on mass spectrometry terms and definitions. In 1978, the IUPAC Commission on Molecular Structure and Spectroscopy updated and extended the recommendations and made further recommendations regarding symbols, acronyms, and abbreviations. The IUPAC Physical Chemistry Division Commission on Molecular Structure and Spectroscopy’s Subcommittee on Mass Spectroscopy revised the recommended terms in 1991 and appended terms relating to vacuum technology. Some additional terms related to tandem mass spectrometry were added in 1993 and accelerator mass spectrometry in 1994. Owing to the rapid expansion of the field in the intervening years, particularly in mass spectrometry of biomolecules, a further revision of the recommendations has become necessary. This document contains a comprehensive revision of mass spectrometry terminology that represents the current consensus of the mass spectrometry community.
Heat-related changes to the hydrophobicity of cheese whey correlate with levels of native β-lactoglobulin and α-lactalbumin (1992)

Correlations were identified between levels of the native whey proteins, beta-lactoglobulin and alpha-lactalbumin and the surface and total hydrophobicities of cheese whey in response to different heat treatments. Heat-induced changes in the native beta-lactoglobulin content and surface hydrophobicity of whey exhibited the most significant linear relationship while correlations between total hydrophobicity and the native proteins were less significant because of an atypical rise in the n-heptane-binding capacity of whey after high-temperature treatment. The content of native beta-lactoglobulin in whey was more sensitive to heating than the content of native alpha-lactalbumin, while heat-related changes in the total hydrophobicity of whey were generally greater than similar changes in surface hydrophobicity.