gebhart/patrepeval huggingface dataset:
Non-neuronal cardiac cholinergic system influences CNS via the vagus nerve to acquire a stress-refractory propensity (2016)

We previously developed cardiac ventricle-specific choline acetyltransferase (ChAT) gene-overexpressing transgenic mice (ChAT tgm), i.e. an in vivo model of the cardiac non-neuronal acetylcholine (NNA) system or non-neuronal cardiac cholinergic system (NNCCS). By using this murine model, we determined that this system was responsible for characteristics of resistance to ischaemia, or hypoxia, via the modulation of cellular energy metabolism and angiogenesis. In line with our previous study, neuronal ChAT-immunoreactivity in the ChAT tgm brains was not altered from that in the wild-type (WT) mice brains; in contrast, the ChAT tgm hearts were the organs with the highest expression of the ChAT transgene. ChAT tgm showed specific traits in a central nervous system (CNS) phenotype, including decreased response to restraint stress, less depressive-like and anxiety-like behaviours and anti-convulsive effects, all of which may benefit the heart. These phenotypes, induced by the activation of cardiac NNCCS, were dependent on the vagus nerve, because vagus nerve stimulation (VS) in WT mice also evoked phenotypes similar to those of ChAT tgm, which display higher vagus nerve discharge frequency; in contrast, lateral vagotomy attenuated these traits in ChAT tgm to levels observed in WT mice. Furthermore, ChAT tgm induced several biomarkers of VS responsible for anti-convulsive and anti-depressive-like effects. These results suggest that the augmentation of the NNCCS transduces an effective and beneficial signal to the afferent pathway, which mimics VS. Therefore, the present study supports our hypothesis that activation of the NNCCS modifies CNS to a more stress-resistant state through vagus nerve activity.
Novel Photosensitizer and Methoxy Styryl Pyridines for Photoradical Initiator System (2009)

Distyryl pyridine (DSP) photosensitizer for HABI photoinitiator systems was newly designed and eleven methoxy DSP(distyrylpyridines)s were synthesized and evaluated. The results showed that 2, 4-dimethoxy DSP (24DMOP-DSP) was the most efficient among studied methoxy DSPs. Compared with coumarin 1 as reference, the photosensitivity for 24DMOP-DSP as photosensitizer was increased by 150%. Potential of DSP as photosensitizer was supported by the mechanism study, such like photobleaching property of 24DMOP-DSP, derived from configuration change of E to Z, and efficient fluorescence quenching of excited singlet DSP by BCIM.
Characterizing incidental mass lesions in abdominal dual-energy CT compared to conventional contrast-enhanced CT (2022)

DECT has the potential to improve the immediate characterization of incidental findings when compared to conventional CT for abdominal imaging.
Aperture Distribution of RLSA for 5.8-GHz band Wireless Power Transmission (2019)

Wireless power transmission system using two radial line slot arrays (RLSA) is proposed in this paper. The RLSAs are placed against each other in near-field region of the antenna. Two different array excitation types, uniform and rotation, are compared in terms of transmission distance and off-axis transmission loss.
Abstract 3309: Identifying glycoproteins in ER+ and ER- human breast cancer tissue samples (2010)

Abstract Breast cancer is the second leading cause of death from cancer in women. New biomarkers for cancer detection and treatment are needed to increase the life expectancy of breast cancer patients. Protein glycosylation is a post translational modification that gives a protein a new function. A change in the glycosylation on a glycoprotein often causes a change in function of that glycoprotein and such phenomenon has been correlated with cancerous transformation. Thus, glycoproteins in human breast cancer estrogen receptor positive (ER+) tissue and those in estrogen receptor negative (ER-) tissue, the more aggressive stage in breast cancer, are compared and a list of glycoproteins possibly showing a difference in their glycosylation were identified using double staining (glyco- and total protein staining) of the 2-DE gels followed by ESI-FTICR analysis and gel spot count was done using ImageQuant TL. Results show that 30% of the total lysate proteins are glycoproteins, where the total proteins in ER+ are slightly higher than that of the ER-, yet the difference between the glycoprotein in the ER+ and ER- is not significant. Alpha-1-acid glycoprotein, Alpha-1-antitrypsin glycoprotein, Annexin A1, Malate dehydrogenase mitochondrial precursor, Myosin-reactive immunoglobulin kappa chain variable region, IGKV1-5, Peroxiredoxin-1, and Superoxide dismutase mitochondrial precursor are the identified glycoproteins in both ER+ and ER- human breast tissue samples. Alpha-1-acid glycoprotein and Alpha-1-antitrypsin glycoprotein are mostly N-glycosylated proteins. Annexin A1, Malate dehydrogenase mitochondrial precursor, and Superoxide dismutase mitochondrial precursor are possibly N- or O-glycoslated proteins, while Myosin-reactive immunoglobulin kappa chain variable region, IGKV1-5, and Peroxiredoxin-1 are possibly mostly O-glycosylated proteins. Among those glycoproteins Alpha-1-acid glycoprotein, Alpha-1-antitrypsin glycoprotein, Annexin A1, Peroxiredoxin-1, Immunoglobulin gamma-1C region, and Superoxide dismutase mitochondrial precursor are important glycoproteins in breast cancer and possible biomarkers during the progression of human breast cancer. (This work was supported in part by grant BCTR0504465 from the Susan G. Komen for the Cure Breast Cancer Foundation, grants from the Florida Breast Cancer Coalition Research Foundation, the Elsa U. Pardee Foundation, and the Florida State University to Prof. Q.-X. Sang) Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3309.
Infinite dilution diffusion coefficients of several alcohols in water (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTInfinite dilution diffusion coefficients of several alcohols in waterSam. F. Y. Li and Hui. M. OngCite this: J. Chem. Eng. Data 1990, 35, 2, 136–137Publication Date (Print):April 1, 1990Publication History Published online1 May 2002Published inissue 1 April 1990https://pubs.acs.org/doi/10.1021/je00060a011https://doi.org/10.1021/je00060a011research-articleACS PublicationsRequest reuse permissionsArticle Views358Altmetric-Citations23LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Metabolites from the Fungal Endophyte <i>Aspergillus austroafricanus</i> in Axenic Culture and in Fungal–Bacterial Mixed Cultures (2016)

The endophytic fungus Aspergillus austroafricanus isolated from leaves of the aquatic plant Eichhornia crassipes was fermented axenically on solid rice medium as well as in mixed cultures with Bacillus subtilis or with Streptomyces lividans. Chromatographic analysis of EtOAc extract of axenic cultures afforded two new metabolites, namely, the xanthone dimer austradixanthone (1) and the sesquiterpene (+)-austrosene (2), along with five known compounds (3-7). Austradixanthone (1) represents the first highly oxygenated heterodimeric xanthone derivative. When A. austroafricanus was grown in mixed cultures with B. subtilis or with S. lividans, several diphenyl ethers (8-11) including the new austramide (8) were induced up to 29-fold. The structures of new compounds were unambiguously elucidated using 1D- and 2D-NMR spectroscopy, HRESIMS, and chemical derivatization. Compound 7 exhibited weak cytotoxicity against the murine lymphoma L5178Y cell line (EC50 is 12.6 μM). In addition, compounds 9 and 10, which were enhanced in mixed fungal/bacterial cultures, proved to be active against Staphylococcus aureus (ATCC 700699) with minimal inhibitory concentrations (MICs) of 25 μM each (6.6 μg/mL), whereas compound 11 revealed moderate antibacterial activity against B. subtilis 168 trpC2 with an MIC value of 34.8 μM (8 μg/mL).
Studies on the radical species of 9-decarboxymethoxatin (1987)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on the radical species of 9-decarboxymethoxatinEvelyn J. Rodriguez, Thomas C. Bruice, and Dale E. EdmondsonCite this: J. Am. Chem. Soc. 1987, 109, 2, 532–537Publication Date (Print):January 1, 1987Publication History Published online1 May 2002Published inissue 1 January 1987https://pubs.acs.org/doi/10.1021/ja00236a035https://doi.org/10.1021/ja00236a035research-articleACS PublicationsRequest reuse permissionsArticle Views65Altmetric-Citations19LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Hybrid Heavy-Ball Systems: Reset Methods for Optimization with\n Uncertainty (2020)

Momentum methods for convex optimization often rely on precise choices of\nalgorithmic parameters, based on knowledge of problem parameters, in order to\nachieve fast convergence, as well as to prevent oscillations that could\nseverely restrict applications of these algorithms to cyber-physical systems.\nTo address these issues, we propose two dynamical systems, named the Hybrid\nHeavy-Ball System and Hybrid-inspired Heavy-Ball System, which employ a\nfeedback mechanism for driving the momentum state toward zero whenever it\npoints in undesired directions. We describe the relationship between the\nproposed systems and their discrete-time counterparts, deriving conditions\nbased on linear matrix inequalities for ensuring exponential rates in both\ncontinuous time and discrete time. We provide numerical LMI results to\nillustrate the effects of our reset mechanisms on convergence rates in a\nsetting that simulates uncertainty of problem parameters. Finally, we\nnumerically demonstrate the efficiency and avoidance of oscillations of the\nproposed systems when solving both strongly convex and non-strongly convex\nproblems.\n
Kallikrein‐related peptidase 5 contributes to the remodeling and repair of bronchial epithelium (2021)

Inflammation, oxidative stress, and protease/protease inhibitor imbalance with excessive production of proteases are factors associated with pathogenesis of the chronic obstructive pulmonary disease (COPD). In this study, we report that kallikrein-related peptidase 5 (KLK5) is a crucial protease involved in extracellular matrix (ECM) remodeling and bronchial epithelial repair after injury. First, we showed that KLK5 degrades the basal layer formed by culture of primary bronchial epithelial cells from COPD or non-COPD patients. Also, exogenous KLK5 acted differently on BEAS-2B cells already engaged in epithelial-to-mesenchymal transition (EMT) or on 16HBE 14o- cells harboring epithelial characteristics. Indeed, by inducing EMT, KLK5 reduced BEAS-2B cell adherence to the ECM. This effect, neutralized by tissue factor pathway inhibitor 2, a kunitz-type serine protease inhibitor, was due to a direct proteolytic activity of KLK5 on E-cadherin, β-catenin, fibronectin, and α5β1 integrin. Thus, KLK5 may strengthen EMT mechanisms and promote the migration of cells by activating the mitogen-activated protein kinase signaling pathway required for this function. In contrast, knockdown of endogenous KLK5 in 16HBE14o- cells, accelerated wound healing repair after injury, and exogenous KLK5 addition delayed the closure repair. These data suggest that among proteases, KLK5 could play a critical role in airway remodeling events associated with COPD during exposure of the pulmonary epithelium to inhaled irritants or smoking and the inflammation process.
Address Mapping System (2019)

This document describes the Address Mapping System that is a generic,
extensible, and scalable system for mapping network addresses to other
network addresses. The Address Mapping System is intended to be used
in conjunction with overlay techniques which facilitate transmission
of packets across overlay networks. Information returned by the
Address Mapping System can include the particular network overlay
method to use, as well as instructions related to using the method.
The Address Mapping System has a number of potential use cases
including identifier-locator protocols, network virtualization, and
promotion of privacy.
Identification of methyl coenzyme M as an intermediate in methanogenesis from acetate in Methanosarcina spp (1984)

The transfer of the methyl group of acetate to coenzyme M (2-mercaptoethanesulfonic acid; HS-CoM) during the metabolism of acetate to methane was investigated in cultures of Methanosarcina strain TM-1. The organism metabolized CD3COO- to 83% CD3H and 17% CD2H2 and produced no CDH3 or CH4. The isotopic composition of coenzyme M in cells grown on CD3COO- was analyzed with a novel gas chromatography-mass spectrometry technique. The cells contained CD3-D-CoM and CD2H-S-CoM) in a proportion similar to that of CD3H to CD2H2. These results, in conjunction with a report (J.K. Nelson and J.G. Ferry, J. Bacteriol. 160:526-532, 1984) that extracts of acetate-grown strain TM-1 contain high levels of CH3-S-CoM methylreductase, indicate that CH3-S-CoM is an intermediate in the metabolism of acetate to methane in this organism.
Evaluation of the novel F-18-labeled PET tracer SMBT-1 for imaging astrogliosis in Alzheimer's disease (2020)

457 Background: Neuroinflammatory changes, characterized by reactive astrocytes and activated microglia, contribute greatly to neurodegeneration throughout the course of Alzheimer’s diseases (AD). Reactive astrocytes overexpress monoamine oxidase-B (MAO-B) in the outer mitochondrial membrane. For imaging astrogliosis in the human brain, we developed the novel MAO-B PET tracer named 18F-SMBT-1. We aimed to investigate the binding properties of 18F-SMBT-1 in healthy elderly controls and AD patients.
 Methods: In vitro binding assays and autoradiography using postmortem brain tissues were performed for the assessment of binding affinity and selectivity of 18F-SMBT-1. Nine participants, 5 healthy elderly controls (3F/2M, 78.5±6.0 yrs) and 4 AD patients (3F/1M, 76.8±1.4 yrs), underwent 18F-SMBT-1 PET, amyloid PET with 18F-NAV4694, tau PET with either 18F-MK6240 or 18F-PI2620. 18F-SMBT-1 studies were expressed as SUV or as tissue ratios using the cerebellar white matter as reference region. To ascertain 18F-SMBT-1 selective binding to MAO-B, participants underwent a second 18F-SMBT-1 scan after receiving 5mg selegiline twice daily for 5 days.
 Results: SMBT-1 showed strong and reversible binding to MAO-B (Kd = 3.7 nM), and low binding affinity to other enzymes, receptors and misfolded proteins such as amyloid-β and tau. Greater amount of 18F-SMBT-1 binding was observed in AD brain tissues than in control brains and these bindings were completely displaced with MAO-B inhibitor lazabemide. In clinical studies, 18F-SMBT-1 yielded high contrast images at 60-90 min post injection. In AD patients, 18F-SMBT-1 retention was significantly higher in parahippocampus, fusiform and inferior temporal gyrus. More than 85% of 18F-SMBT-1 signal was blocked and no residual cortical activity was observed after the selegiline regimen, indicating high selectivity for MAO-B.
 Conclusions: 18F-SMBT-1 is the highly selective MAO-B tracer, which will enable the assessment of astrogliosis in the human brain. The confirmation of these preliminary findings with 18F-SMBT-1 will require examination of a much larger series, including participants with MCI and prodromal AD.
Gastric neurology: evolving concepts and techniques. (1998)

Gastric function is finely modulated by a series of neurological mechanisms, so that gastric digestion is normally not perceived. Alteration of these control mechanisms may lead to different situations, which are frequently associated with symptoms. An impaired tonic contraction of the proximal stomach, that is, an impaired gastric tone, results in gastroparesis. Patients with functional dyspepsia, and also patients with achalasia, have impaired meal accommodation of the stomach. Interestingly, patients with functional dyspepsia may also have a sensory dysfunction, and both dysfunctions could play a synergistic role. However, the sensory dysfunction in dyspepsia, particularly the types of afferent fibres affected, and the mechanisms of impaired accommodation, still remain to be characterized. Evaluation of gastric function has been approached using the barostat. However, the barostat has limitations and potential technical pitfalls that require proper attention. Meal ingestion induces a variety of reflexes and the net result is a relaxation of the stomach. However, gastric reflexes can be best evaluated with the stomach empty, when the stimuli are applied at a different site. Nevertheless, altered reflex responses may be difficult to interpret. For instance, absent or decreased relaxatory responses may equally correspond to a gastroparetic stomach without tone or to a dyspeptic stomach unable to relax. In this context, it may be important to measure basal tone. Distension of the stomach by means of the barostat has been also used to test gastric sensitivity. However, recent studies have shown that perception of gastric distension relays on stimulation of tension receptors; since wall tension depends on both pressure and volume, distension with the barostat may be difficult to standardize. Hopefully, a battery of tests may become available in the near future for a complete neuromuscular evaluation of the gut.
20905 Formulation of human model for elbow joint Dynamic Simulation (2010)

Made a Simulation model of forearm including elbow joint, proximal and distal radio-ulnar joint, was produced on virtual space from CT and MRI data in this study. This model consisted of bone, ligament, and muscle component. Simulation model changed setting of a ligament, and compared each generated model movement, and MRI data, and inspected the method for construction of simulation model with clinical application, and a function of each ligament. As a result, the simu- lation model was able to generate flexural movement on virtual space. And, from comparison of each model movement, a restriction state of an Medial collateral ligament influenced in stability of elbow movement. In addition, Lateral ligament complex, errors of model movement was increased by annular ligament rupture or rupture of a ligament supporting it.
Multi-View Learning and Link Farm Discovery (2006)

The first part of this abstract focuses on estimation of mixture models for problems in which multiple views of the instances are available. Examples of this setting include clustering web pages or research papers that have intrinsic (text) and extrinsic (references) attributes. Mixture model estimation is a key problem for both semi-supervised and unsupervised learning. An appropriate optimization criterion quantifies the likelihood and the consensus among models in the individual views; maximizing this consensus minimizes a bound on the risk of assigning an instance to an incorrect mixture component. An EM algorithm maximizes this criterion. The second part of this abstract focuses on the problem of identifying link spam. Search engine optimizers inflate the page rank of a target site by spinning an artificial web for the sole purpose of providing inbound links to the target. Discriminating natural from artificial web sites is a difficult multi-view problem.
Abstract 10677: A Systems Biology Approach Demonstrating the Association Between Mir 122-5p and Glutamine Metabolism With Cardiovascular Health in Black Adults: Results From the Morehouse-Emory Cardiovascular (meca) Center for Health Equity (2022)

Intro: Integrative analysis of extracellular microRNA (miRNA) and metabolomics is a novel approach to identifying molecular pathways underlying cardiovascular health (CVH). Levels of miRNAs are linked to cardiovascular disease (CVD), while cardiometabolic risk factors are known to alter activity of select metabolic pathways. We identified miRNAs and metabolites underlying CVH in a cohort of Black adults through an integrative analysis of extracellular miRNA levels, metabolite concentrations and clinical factors associated with CVH. Methods: The MECA cohort consisted of 371 Black adults (age 53+10, 38.5% male) without known CVD. CVH was determined by Life’s Simple 7 (LS7) score, calculated from blood pressure, fasting glucose, cholesterol, BMI, exercise, diet, and smoking. Metabolite concentrations in plasma was assessed by high-resolution metabolomics profiling, and expression of miRs-122-5p, -150-5p, and -30c-5p was assessed by RT-qPCR. Metabolome wide association study (MWAS) identified metabolites associated with LS7. Association of miRNA levels with CVH clinical domains was assessed using Spearman correlation. Integrative analysis of select miRNAs, metabolites, and CVH clinical domains was performed using the program xMWAS. Results: Expression of 30 metabolites was associated with improved CVH (FDR&lt;0.2) where glutamine was higher (p=0.005), and glutamate was lower (p&lt;0.001). Integrative analysis showed association between miR-122-5p, glutamine and fasting glucose. miR-122-5p expression independently correlated with fasting glucose (p=0.03) and glutamine/glutamate is known to be associated with glucose metabolism. In silico and in vitro analyses revealed glutamine synthetase as a potential target of miR-122-5p (Fig). Conclusions: We demonstrate novel associations between glutamine, miR-122-5p and fasting glucose in CVH, suggesting that select metabolites and miRNAs are markers of CVH and maybe potential therapeutic targets.
1 Gb/s operation and bit-error rate studies of FET-SEED diode-clamped smart-pixel optical receivers (1995)

Experimental studies of the bit-error rate (BER) of diode-clamped optical receivers based on FET-SEED technology are described. 1 Gb/s operation of a receiver with optical input and electrical output is obtained. A strong dependence of the BER on clamping voltage is reported, confirming the digital nature of the receiver. The best receiver sensitivity measured at 1 Gb/s and an error rate of 1/spl times/10/sup -9/ is roughly -11 dBm. At 622 Mb/s, it is -22 dBm.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>