PD17-03 COMPARATIVE ANALYSES OF MICRO-ULTRASOUND VERSUS MRI-TARGETED BIOPSY FOR THE DIAGNOSIS OF CLINICALLY SIGNIFICANT PROSTATE CANCER. PRELIMINARY RESULTS FROM THE PROSPECTIVE US-MIRROR TRIAL (2022)

You have accessJournal of UrologyCME1 May 2022PD17-03 COMPARATIVE ANALYSES OF MICRO-ULTRASOUND VERSUS MRI-TARGETED BIOPSY FOR THE DIAGNOSIS OF CLINICALLY SIGNIFICANT PROSTATE CANCER. PRELIMINARY RESULTS FROM THE PROSPECTIVE US-MIRROR TRIAL Simone Scuderi, Armando Stabile, Gabriele Sorce, Mario De Angelis, Luigi Nocera, Francesco Pellegrino, Francesco Barletta, Andrea Salonia, Giuseppe Cirulli, Lucia D’Ambrosio, Giorgio Gandaglia, Vito Cucchiara, Elio Mazzone, Giuseppe Rosiello, Riccardo Leni, Donato Cannoletta, Antony Pellegrino, Nicola Fossati, Shahrokh Shariat, Francesco Montorsi, and Alberto Briganti Simone ScuderiSimone Scuderi More articles by this author , Armando StabileArmando Stabile More articles by this author , Gabriele SorceGabriele Sorce More articles by this author , Mario De AngelisMario De Angelis More articles by this author , Luigi NoceraLuigi Nocera More articles by this author , Francesco PellegrinoFrancesco Pellegrino More articles by this author , Francesco BarlettaFrancesco Barletta More articles by this author , Andrea SaloniaAndrea Salonia More articles by this author , Giuseppe CirulliGiuseppe Cirulli More articles by this author , Lucia D’AmbrosioLucia D’Ambrosio More articles by this author , Giorgio GandagliaGiorgio Gandaglia More articles by this author , Vito CucchiaraVito Cucchiara More articles by this author , Elio MazzoneElio Mazzone More articles by this author , Giuseppe RosielloGiuseppe Rosiello More articles by this author , Riccardo LeniRiccardo Leni More articles by this author , Donato CannolettaDonato Cannoletta More articles by this author , Antony PellegrinoAntony Pellegrino More articles by this author , Nicola FossatiNicola Fossati More articles by this author , Shahrokh ShariatShahrokh Shariat More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Alberto BrigantiAlberto Briganti More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000002555.03AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: There is currently increasing interest on the use of micro-ultrasound (micro-US) as new imaging modality approach in the diagnosis of prostate cancer (PCa). However, current evidence is limited by the fact that most studies testing this novel technique have been performed only men with lesion already visible at multi-parametric (mp-MRI). In this prospective paired-cohort trial, we aimed at performing a head-to-head comparison between micro-US and mpMRI for the diagnosis of clinically significant PCa (csPCa) in a population of men with clinical suspicion of PCa. METHODS: This is a prospective, single center paired-cohort trial (NCT04832997). After Ethical approval, each patient received both mpMRI and micro-US in a randomized sequence followed by systematic prostate biopsy plus mpMRI and/or micro-US targeted biopsy. Each mpMRI was centrally performed by an experienced radiologist that was blinded for micro-US result. We compared the diagnostic accuracy of micro-US versus mpMRI in detecting csPCa (defined as PCa with Gleason score ≥ 7) in terms of sensitivity, specificity, negative (NPV) and positive (PPV) predictive values. RESULTS: Since October 2020, 85 men were enrolled in the study. Overall, 64 men with clinical suspicion of PCa received both micro-US and mpMRI. The two tests were either both negative or positive in 28/64 patients (43%) of men while discordance between the two tests was reported in the remaining 36/64 patients (57%). Overall, 73% and 48% of men had a positive micro-US and a positive mpMRI, respectively. Among those 32 men who completed the study receiving prostate biopsy, 47% and 28% of men were diagnosed with PCa and csPCa, respectively. Sensitivity, specificity, PPV and negative NPV of micro-US vs mpMRI for csPCa were 67% vs 100%, 57% vs 57%, 38% vs 47% and 81% vs 100%, respectively. Micro-US increased the detection of clinically insignificant PCa by 6% while mpMRI allowed to increase the detection of csPCa by 9%. CONCLUSIONS: Our preliminary results showed that the accuracy of micro-US for the detection of csPCa detection was lower as compared to mpMRI. Further evidence is needed to support these preliminary results. Source of Funding: None © 2022 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 207Issue Supplement 5May 2022Page: e336 Advertisement Copyright & Permissions© 2022 by American Urological Association Education and Research, Inc.MetricsAuthor Information Simone Scuderi More articles by this author Armando Stabile More articles by this author Gabriele Sorce More articles by this author Mario De Angelis More articles by this author Luigi Nocera More articles by this author Francesco Pellegrino More articles by this author Francesco Barletta More articles by this author Andrea Salonia More articles by this author Giuseppe Cirulli More articles by this author Lucia D’Ambrosio More articles by this author Giorgio Gandaglia More articles by this author Vito Cucchiara More articles by this author Elio Mazzone More articles by this author Giuseppe Rosiello More articles by this author Riccardo Leni More articles by this author Donato Cannoletta More articles by this author Antony Pellegrino More articles by this author Nicola Fossati More articles by this author Shahrokh Shariat More articles by this author Francesco Montorsi More articles by this author Alberto Briganti More articles by this author Expand All Advertisement PDF DownloadLoading ...