gebhart/patrepeval huggingface dataset:
ChemInform Abstract: Synthesis and Pharmacological Screening of Novel Non‐acidic Gastroprotective Antipyretic Antiinflammatory Agents with Antiplatelet Properties. 5‐Alkyl/Cycloalkylamino Substituted 2‐Amino‐5H‐[1]benzopyrano[4,3‐d]pyrimidines. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Cost-effectiveness of dutasteride-tamsulosin combination therapy for the treatment of symptomatic benign prostatic hyperplasia: A Canadian model based on the CombAT trial (2012)

Combination therapy offers important clinical benefits for patients with symptomatic BPH, and there is a high probability that it is cost-effective in the Canadian health care system relative to either monotherapy.
A copper(I) catalyst for carbene and nitrene transfer to form cyclopropanes, cyclopropenes, and aziridines (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA copper(I) catalyst for carbene and nitrene transfer to form cyclopropanes, cyclopropenes, and aziridinesPedro J. Perez, M. Brookhart, and J. L. TempletonCite this: Organometallics 1993, 12, 2, 261–262Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://pubs.acs.org/doi/10.1021/om00026a007https://doi.org/10.1021/om00026a007research-articleACS PublicationsRequest reuse permissionsArticle Views1514Altmetric-Citations137LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A novel non-canonical Notch signaling regulates expression of synaptic vesicle proteins in excitatory neurons (2016)

Notch signaling plays crucial roles for cellular differentiation during development through γ-secretase-dependent intramembrane proteolysis followed by transcription of target genes. Although recent studies implicate that Notch regulates synaptic plasticity or cognitive performance, the molecular mechanism how Notch works in mature neurons remains uncertain. Here we demonstrate that a novel Notch signaling is involved in expression of synaptic proteins in postmitotic neurons. Levels of several synaptic vesicle proteins including synaptophysin 1 and VGLUT1 were increased when neurons were cocultured with Notch ligands-expressing NIH3T3 cells. Neuron-specific deletion of Notch genes decreased these proteins, suggesting that Notch signaling maintains the expression of synaptic vesicle proteins in a cell-autonomous manner. Unexpectedly, cGMP-dependent protein kinase (PKG) inhibitor, but not γ-secretase inhibitor, abolished the elevation of synaptic vesicle proteins, suggesting that generation of Notch intracellular domain is dispensable for this function. These data uncover a ligand-dependent, but γ-secretase-independent, non-canonical Notch signaling involved in presynaptic protein expression in postmitotic neurons.
A survey on life logging data capturing (2012)

As advocates for health, nurses are ideally situated to deliver effective health promotion in their daily interactions with people. This work evaluates the integration of healthy conversation training, making every contact count (MECC), into a health promotion module in an undergraduate nursing degree at a higher education institute (HEI). In all, 108 students completed the online questionnaire I year after receiving healthy conversation training. 67% of students reported the regular or occasional use of healthy conversation skills and identified a wide range of scenarios where they had used the skills. 65% of students used health action planning framework in their own personal self-care. Student nurses acknowledged barriers and enablers to their use of healthy conversation skills. Having knowledgeable mentors who role modelled healthy conversations skills in their consultations was the most frequently raised factor, in addition to lack of knowledge of local resources, time and confidence. All placement settings should ensure that registered nurses, especially those undertaking mentorship responsibilities have access to healthy conversation training.
Efficient Synthesis of γ-Lactams by a Tandem Reductive Amination/Lactamization Sequence (2008)

A three-component method for the synthesis of highly substituted gamma-lactams from readily available maleimides, aldehydes, and amines is described. A new reductive amination/intramolecular lactamization sequence provides a straightforward route to the lactam products in a single manipulation. The general utility of this method is demonstrated by the parallel synthesis of a gamma-lactam library.
Stripline resonator measurements of Z/sub s/ versus H/sub rf/ in YBa/sub 2/Cu/sub 3/O/sub 7-x/ thin films (1991)

A report is presented on measurements of the surface impedance, Z/sub S/, of YBa/sub 2/Cu/sub 3/O/sub 7-x/ thin films using a stripline resonator. The films were deposited on LaAlO/sub 3/ substrates by off-axis magnetron sputtering. The authors obtained Z/sub S/ as a function of frequency from 1.5 to 20 GHz, as a function of temperature from 4 K to the transition temperature ( approximately 90 K), and as a function of the RF magnetic field from zero to 300 Oe. At low temperatures the surface resistance, R/sub S/, of the films shows a very weak dependence on the magnetic field up to 225 to 250 Oe. At 77 K, R/sub S/ is proportional to the square of the field. The penetration depth shows a much weaker dependence on the field than does R/sub S/. The origins of the magnetic field dependence of Z/sub S/ are also discussed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Molecular mechanics (MM2) calculations on peptides and on the protein Crambin using the CYBER 205 (1989)

Abstract The MM2 potential functions for amides and peptides have been further extended by examining the experimental crystal structures for cyclo‐(‐Ala‐Ala‐Gly‐Gly‐Ala‐Gly‐), I, and cyclo‐(‐Ala‐Ala‐Gly‐Ala‐Gly‐Gly‐), II. The force field obtained was then applied to a study of the structure of the hydrophobic protein Crambin, for which a high resolution crystal structure is available. The energy minimization was carried out using a version of MM2 adapted to the CYBER 205.
Analysis of aerosol-cloud interactions and their implications for precipitation formation using aircraft observations over the United Arab Emirates (2021)

Abstract. Aerosol and cloud microphysical measurements were collected by a research aircraft during August 2019 over the United Arab Emirates (UAE). The majority of science flights targeted summertime convection along the eastern Hajar mountains bordering Oman, while one flight sampled non-orographic clouds over the western UAE near the Saudi Arabian border. In this work, we study the evolution of growing cloud turrets from cloud base (9 °C) up to the capping inversion level (−12 °C) using coincident cloud particle imagery and particle size distributions from cloud cores under different forcing. Results demonstrate the active role of background dust and pollution as cloud condensation nuclei (CCN) with the onset of their deliquescence in the sub-cloud region. Sub-cloud aerosol sizes are shown to extend from submicron to 100 µm sizes, with higher concentrations of ultra-giant CCN (d &gt;10 µm) from local sources closer to the Saudi border, compared to the eastern orographic region where smaller size CCN are observed. Despite the presence of ultra-giant CCN from dust and pollution in both regions, an active collision-coalescence (C-C) process is not observed within the limited depths of warm cloud (&lt; 1000 m). The state-of-the-art observations presented in this paper can be used to initialize modelling case studies to study the influence of aerosols on cloud and precipitation processes in the region and to better understand the impacts of hygroscopic cloud-seeding on these clouds.
Streaming Algorithms for Submodular Function Maximization (2015)

We consider the problem of maximizing a nonnegative submodular set function $f:2^{\mathcal{N}} \rightarrow \mathbb{R}^+$ subject to a $p$-matchoid constraint in the single-pass streaming setting. Previous work in this context has considered streaming algorithms for modular functions and monotone submodular functions. The main result is for submodular functions that are {\em non-monotone}. We describe deterministic and randomized algorithms that obtain a $Ω(\frac{1}{p})$-approximation using $O(k \log k)$-space, where $k$ is an upper bound on the cardinality of the desired set. The model assumes value oracle access to $f$ and membership oracles for the matroids defining the $p$-matchoid constraint.
Molecular Mechanisms Regulating LPS-Induced Inflammation in the Brain (2016)

Neuro-inflammation, one of the pathogenic causes of neurodegenerative diseases, is regulated through the cholinergic anti-inflammatory pathway via the α7 nicotinic acetylcholine receptor (α7 nAChR). We previously showed that either bacterial lipopolysaccharide (LPS) or immunization with the α7(1-208) nAChR fragment decrease α7 nAChRs density in the mouse brain, exacerbating chronic inflammation, beta-amyloid accumulation and episodic memory decline, which mimic the early stages of Alzheimer's disease (AD). To study the molecular mechanisms underlying the LPS and antibody effects in the brain, we employed an in vivo model of acute LPS-induced inflammation and an in vitro model of cultured glioblastoma U373 cells. Here, we report that LPS challenge decreased the levels of α7 nAChR RNA and protein and of acetylcholinesterase (AChE) RNA and activity in distinct mouse brain regions, sensitized brain mitochondria to the apoptogenic effect of Ca(2+) and modified brain microRNA profiles, including the cholinergic-regulatory CholinomiRs-132/212, in favor of anti-inflammatory and pro-apoptotic ones. Adding α7(1-208)-specific antibodies to the LPS challenge prevented elevation of both the anti-inflammatory and pro-apoptotic miRNAs while supporting the resistance of brain mitochondria to Ca(2+) and maintaining α7 nAChR/AChE decreases. In U373 cells, α7-specific antibodies and LPS both stimulated interleukin-6 production through the p38/Src-dependent pathway. Our findings demonstrate that acute LPS-induced inflammation induces the cholinergic anti-inflammatory pathway in the brain, that α7 nAChR down-regulation limits this pathway, and that α7-specific antibodies aggravate neuroinflammation by inducing the pro-inflammatory interleukin-6 and dampening anti-inflammatory miRNAs; however, these antibodies may protect brain mitochondria and decrease the levels of pro-apoptotic miRNAs, preventing LPS-induced neurodegeneration.
Halogen‐induced chemical copolymerization of pyrrole with <i>N</i>‐methylpyrrole (1989)

Abstract Simultaneous chemical copolymerization and oxidation of pyrrole and N ‐methylpyrrole by bromine an iodine has been carried out. The composition of the copolymes can be effectvely controlled by varying the monomer feed ratio. From elemental analysis the copolymer composition and the monomer reactivity ratios have been determined. As the copolymer composition changes, the IR absorption spectra show changes in the intensity of certain bands. In bromineinduced polymerization, the electrical conductivity, the electrical conductivity, thermal stability, and bromine content of the copolymer complex decrease with increase in N ‐mthylpyrrole fraction. X‐ray photoelectron spectroscopy data suggest that a fixed fraction of bromine is incroporated as covalent bromide in the copolymer complex. When iodine is used the halogen content do not show substantial differences among the copolymers but the electricdal conductivity and thermal stability of the copolymers also decrease with increase in N ‐methylpyrrole fraction.
ChemInform Abstract: Toward the Synthesis of Novel Fluorinated Building Blocks: 3,4‐Difluorothiophene‐1,1‐dioxide. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ONE-TOUCH FINANCIAL TRANSACTION AUTHENTICATION (2009)

We present a design for a Wi-Fi user-authentication token that tunnels data through the SSID field, packet timing, and packet length. Previous attempts to build an online-banking transaction-signing token have been only moderately successful, due in large part to usability problems. Average consumers, especially in the United States, are simply unwilling to transcribe strings of digits from PC to token and back again. In a departure from previous work, our token communicates using point-to-point side-channels in Wi-Fi that allow two devices to directly exchange messages – even if one is also connected to an access point. The result is a token that can authenticate transactions using only one touch by the user. The increased usability means more transactions can be authenticated, reducing fraud and driving more banking business online.
Understanding the Mechanism of Polymerization of ε-Caprolactone Catalyzed by Aluminum Salen Complexes (2013)

Studies of the kinetics of polymerization of ε-caprolactone (CL) by salen-aluminum catalysts comprising ligands with similar steric profiles but different electron donating characteristics (R = OMe, Br, or NO2) were performed using high initial monomer concentrations (2 M < [CL]0 < 2.6 M) in toluene-d8 at temperatures ranging from 20 to 90 °C. Saturation behavior was observed, enabling determination of monomer equilibrium constants (Keq) and catalytic rate constants (k2) as a function of R and temperature. While Keq varied only slightly with the electron donating properties of R (Hammett ρ = +0.16(8)), k2 showed a more significant dependence reflected by ρ = +1.4(1). Thermodynamic parameters ΔG° (associated with Keq) and ΔG(‡) (associated with k2) were determined, with the former being ∼0 kcal/mol for all catalysts and the latter exhibiting the trend R = OMe > Br > NO2. Density functional theory (DFT) calculations were performed to characterize mechanistic pathways at a microscopic level of detail. Lowest energy transition-state structures feature incipient bonding of the nucleophile to the lactone carbonyl that is approaching the metal ion, but a distinct CL adduct is not an energy minimum on the reaction pathway, arguing against Keq being associated with coordination of monomer according to the typical coordination-insertion mechanism. An alternative hypothesis is presented associating Keq with "nonproductive" coordination of substrate in a manner that inhibits the polymerization reaction at high substrate concentrations.
[Diagnosis and therapy of bradycardial arrhythmias]. (1983)

Diagnostic and therapeutic procedures in bradyarrhythmias are discussed. Special attention is paid to cases with suspected but still undocumented bradycardias and to some aspects of differential therapy.
Aqueous Biphasic Dye‐Sensitized Photosynthesis Cells for TEMPO‐Based Oxidation of Glycerol (2022)

Abstract This work reports an aqueous dye‐sensitized photoelectrochemical cell (DSPEC) capable of oxidizing glycerol (an archetypical biobased compound) coupled with H 2 production. We employed a mesoporous TiO 2 photoanode sensitized with the high potential thienopyrroledione‐based dye AP11 , encased in an acetonitrile‐based redox‐gel that protects the photoanode from degradation by aqueous electrolytes. The use of the gel creates a biphasic system with an interface at the organic (gel) electrode and aqueous anolyte. Embedded in the acetonitrile gel is 2,2,6,6‐tetramethylpiperidine‐1‐oxyl ( TEMPO ), acting as both a redox‐mediator and a catalyst for oxidative transformations. Upon oxidation of TEMPO by the photoexcited dye, the in situ generated TEMPO + shuttles through the gel to the acetonitrile – aqueous interface, where it acts as an oxidant for the selective conversion of glycerol to glyceraldehyde. The introduction of the redox‐gel layer affords a 10‐fold increase in the conversion of glycerol compared to the purely aqueous system. Our redox‐gel protected photoanode yielded a stable photocurrent over 48 hours of continuous operation, demonstrating that this DSPEC is compatible with alkaline aqueous reactions.
A New Sparse Representation Framework for Reconstruction of an Isotropic High Spatial Resolution MR Volume From Orthogonal Anisotropic Resolution Scans (2017)

In magnetic resonance (MR), hardware limitations, scan time constraints, and patient movement often result in the acquisition of anisotropic 3-D MR images with limited spatial resolution in the out-of-plane views. Our goal is to construct an isotropic high-resolution (HR) 3-D MR image through upsampling and fusion of orthogonal anisotropic input scans. We propose a multiframe super-resolution (SR) reconstruction technique based on sparse representation of MR images. Our proposed algorithm exploits the correspondence between the HR slices and the low-resolution (LR) sections of the orthogonal input scans as well as the self-similarity of each input scan to train pairs of overcomplete dictionaries that are used in a sparse-land local model to upsample the input scans. The upsampled images are then combined using wavelet fusion and error backprojection to reconstruct an image. Features are learned from the data and no extra training set is needed. Qualitative and quantitative analyses were conducted to evaluate the proposed algorithm using simulated and clinical MR scans. Experimental results show that the proposed algorithm achieves promising results in terms of peak signal-to-noise ratio, structural similarity image index, intensity profiles, and visualization of small structures obscured in the LR imaging process due to partial volume effects. Our novel SR algorithm outperforms the nonlocal means (NLM) method using self-similarity, NLM method using self-similarity and image prior, self-training dictionary learning-based SR method, averaging of upsampled scans, and the wavelet fusion method. Our SR algorithm can reduce through-plane partial volume artifact by combining multiple orthogonal MR scans, and thus can potentially improve medical image analysis, research, and clinical diagnosis.
Analysis of Instantaneous Linear, Nonlinear and Complex Cardiovascular Dynamics from Videophotoplethysmography (2018)

Although significant differences exist between cardiovascular estimates from vPPG and ECG, it is very promising that instantaneous sympathovagal changes, as well as time-varying complex dynamics, were correctly identified, especially during resting state. In addition to a further improvement of the video signal quality, more research is advocated towards a more precise estimation of cardiovascular dynamics by a comprehensive nonlinear/complex paradigm specifically tailored to the non-contact quantification.
Monte Carlo iodine brachytherapy dosimetry: study for a clinical application (2008)

At present, all clinical algorithms used in brachytherapy are based on the TG-43 algorithm, which has the advantage to offer very fast calculation time. However, this formalism has many simplifications, assuming for example the patient tissue composition equivalent to water. For low energy brachytherapy seeds such as iodine seeds, it is of interest to evaluate the dosimetric differences between calculations based on Monte Carlo simulations (considered the gold standard) and the TG-43 formalism. For a 6711 model 125I seed calculated photon spectra were compared to spectra measured with a CdTe spectrometer. Good agreement was found except for the lowest energy peak which seems to be over-estimated by the experiment due to the contribution of the spectrometer CdTe diode to the measurement. Dose distributions in water are measured with EBT Gafchromic film and compared to the Monte Carlo calculation. A very good agreement is found. Finally, the method to create a MCNPX input file from computed tomography (CT) scanner images is explained and some preliminary isodose distributions are presented.
Hemoglobin Signal Network Mapping Reveals Novel Indicators for Precision Medicine (2023)

Abstract We introduce methodology, applied to a representative physiological time series measure (fNIRS) and disease type (breast cancer), that provides access to features more typical of molecular-cellular processes but here are observed from intact tissue. The methodology adopts a novel approach to generating a multivariate ordinal partition transition network to enable quantitative descriptions of short-term dynamics (&lt;1sec). Accessed are several classes of adjacency matrices whose exploration and associated co-dependent behaviors unexpectedly reveals features of structured dynamics, some of which are shown to exhibit enzyme-like behaviors and sensitivity to recognized molecular markers of disease. Constituting class measures that are often easily applied and widely accessible, such sensitivities may afford novel extensions to on-demand phenotypic measures that have thus far had limited utility for complementing precision medicine strategies. Discussed are exemplary uses in support of this aim, and extension to other forms of physiological time series measures.
Long‐Term Safety and Tolerability of Apremilast Versus Placebo in Psoriatic Arthritis: A Pooled Safety Analysis of Three Phase III, Randomized, Controlled Trials (2020)

Apremilast demonstrated a favorable safety profile and was well tolerated up to 156 weeks.
Development and field experiences of stabilization system using 34MW NAS batteries for a 51MW wind farm (2010)

Wind turbines (WTs) are considered to be one of effective approach to solve global warming and energy issues. However, the output of WTs depends on the weather conditions and the natural environment, which cause large fluctuations in the output power, leading to insufficient of frequency adjustment capacity of the power grid. Several methods have been examined to compensate for such large fluctuations using batteries. In this paper, we describe the development of the world's largest constant output stabilization system using 34 MW sodium sulfur (NAS) batteries for a 51 MW wind farm at Futamata in the Tohoku district of Japan, as well as our field experiences indicating excellent operating performance.