gebhart/patrepeval huggingface dataset:
Data from The &lt;i&gt;MCT4&lt;/i&gt; Gene: A Novel, Potential Target for Therapy of Advanced Prostate Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The management of castration-resistant prostate cancer (CRPC) is a major challenge in the clinic. Androgen receptor signaling–directed strategies are not curative in CRPC therapy, and new strategies targeting alternative, key cancer properties are needed. Using reprogrammed glucose metabolism (aerobic glycolysis), cancer cells typically secrete excessive amounts of lactic acid into their microenvironment, promoting cancer development, survival, and progression. Cellular lactic acid secretion is thought to be predominantly mediated by MCT4, a plasma membrane transporter protein. As such, the &lt;i&gt;MCT4&lt;/i&gt; gene provides a unique, potential therapeutic target for cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; A tissue microarray of various Gleason grade human prostate cancers was stained for MCT4 protein. Specific, &lt;i&gt;MCT4&lt;/i&gt;-targeting antisense oligonucleotides (MCT4 ASO) were designed and candidate MCT4 ASOs checked for effects on (i) MCT4 expression, lactic acid secretion/content, glucose consumption, glycolytic gene expression, and proliferation of human CRPC cells and (ii) growth of PC-3 tumors in nude mice.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Elevated MCT4 expression was associated with human CRPC and an earlier time to relapse. The treatment of PC-3, DU145, and C4-2 CRPC cultures with candidate MCT4 ASOs led to marked inhibition of MCT4 expression, lactic acid secretion, to increased intracellular lactic acid levels, and markedly reduced aerobic glycolysis and cell proliferation. Treatment of PC-3 tumor-bearing nude mice with the MCT4 ASOs markedly inhibited tumor growth without inducing major host toxicity.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; &lt;i&gt;MCT4&lt;/i&gt;-targeting ASOs that inhibit lactic acid secretion may be useful for therapy of CRPC and other cancers, as they can interfere with reprogrammed energy metabolism of cancers, an emerging hallmark of cancer. &lt;i&gt;Clin Cancer Res; 22(11); 2721–33. ©2016 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Chirurgie des fractures vertébrales (2013)

Les taux élevés de morbidité et de mortalité associés aux fractures vertébrales ostéoporotiques résultent d’une cyphose progressive, s’accompagnant d’une altération de l’équilibre sagittal et spino-pelvien. Toute intervention chirurgicale doit viser à prévenir la progression de la cyphose et à rétablir l’équilibre sagittal et spino-pelvien.
Molecular Docking and ADME Studies of Natural Compounds of Agarwood Oil for Topical Anti-Inflammatory Activity (2013)

Aquilaria agallocha Roxb. family, Thymelaeaceae, is an evergreen plant of South-East Asia, commonly described as aloe wood or agarwood. Traditionally, the bark, root and heartwood are used for their medicinal properties as a folk medicine for hundreds of years. Chemical analyses revealed that the bulk of the oil is constituted by agarospirol (12.5%), jinkoh-eremol (11.8%) and hinesol (8.9%) as major contributor. In the present work, a QSAR model for antiinflammatory activity of 10-epi-γ-Eudesmol, jinkoh-eremol, agarospirol and other compounds has been developed by multiple linear regression method. The r(2) and rCV(2) of a model were 0.89 and 0.81 respectively. In silico molecular docking study suggests that compound 10-epi-γ-Eudesmol, jinkoh-eremol and agarospirol are preferentially more active than other identified compounds with strong binding affinity to major anti-inflammatory and immunomodulatory receptors. The oil displayed a significant and dose dependent reduction of 12-O-tetradecanoylphorobol-13 acetate (TPA)- induced ear edema and MDA activity when compared with vehicle treated mice. Pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α) were also reduced significantly in a dose dependent manner in all the TPA treated groups as compared to control. The present study indicates that agarwood oil significantly reduced the skin thickness, ear weight, oxidative stress and pro-inflammatory cytokines production in TPA-induced mouse ear inflammation model and contributed towards validation of its traditional use to treat inflammation related ailments.
A case of hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome with a novel frameshift variant in <i>GATA3</i>, p.W10Cfs40, lacks kidney malformation (2020)

Autosomal dominant hypoparathyroidism, deafness, and renal dysplasia (HDR) syndrome are typically diagnosed by manifestations of the three features with a positive family history. Our case carried a de novo variant in causative gene, <i>GATA3,</i> but presenting no renal dysplasia or family history. The phenotypic heterogeneity raises a caution for diagnosis.
Adsorption Inhibitors: A New Route to Mitigate Adsorption in Chemical Enhanced Oil Recovery (2015)

Abstract In this paper, we present a new route to mitigate surfactant retention in chemical EOR projects. Surfactants retention, either through adsorption on reservoir rocks or phase trapping, is one of the main constraints to achieve high performance and economical chemical EOR. Specific injection strategies thus need to be developed to mitigate surfactants retention. The use of alkaline and/or salinity gradient approaches present the disadvantage of being restricted to very specific conditions. For example, in hard brine environments, alkalis cannot be used because they can cause scaling. In an offshore environment, as sea water is the only injection water available, water treatment is required in order to use alkali or to perform a salinity gradient. The new route to mitigate adsorption proposed in this paper is based on the use of specific, cost effective, chemical additives which allow mimicking the effect of salinity gradient. The resulting processes, when properly optimized, can achieve very high performances in terms of oil recovery with a limited amount of injected chemicals. Final performance, at lab scale, is comparable to the highly performing ASP/ SP processes in soft brines with salinity gradient.
Waveforms for xG Non-stationary Channels (2023)

Waveform design for interference cancellation in next-generation wireless systems, which includes precoding and modulation, aims to achieve orthogonality among data signals/symbols across all Degrees of Freedom (DoF). Conventional methods struggle with non-stationary channel states due to high mobility, density, and time-varying multipath propagation. In this article, we review the HOGMT-Precoding and MEM modulations for non-stationary channels. We also discuss practical challenges and future directions.
Regulation of the human ether-a-gogo related gene (HERG) K<sup>+</sup>channels by reactive oxygen species (1997)

Human ether-a-gogo related gene (HERG) K+ channels are key elements in the control of cell excitability in both the cardiovascular and the central nervous systems. For this reason, the possible modulation by reactive oxygen species (ROS) of HERG and other cloned K+ channels expressed in Xenopus oocytes has been explored in the present study. Exposure of Xenopus oocytes to an extracellular solution containing FeSO4 (25-100 microM) and ascorbic acid (50-200 microM) (Fe/Asc) increased both malondialdehyde content and 2',7'-dichlorofluorescin fluorescence, two indexes of ROS production. Oocyte perfusion with Fe/Asc caused a 50% increase of the outward K+ currents carried by HERG channels, whereas inward currents were not modified. This ROS-induced increase in HERG outward K+ currents was due to a depolarizing shift of the voltage-dependence of channel inactivation, with no change in channel activation. No effect of Fe/Asc was observed on the expressed K+ currents carried by other K+ channels such as bEAG, rDRK1, and mIRK1. Fe/Asc-induced stimulation of HERG outward currents was completely prevented by perfusion of the oocytes with a ROS scavenger mixture (containing 1,000 units/ml catalase, 200 ng/ml superoxide dismutase, and 2 mM mannitol). Furthermore, the scavenger mixture also was able to reduce HERG outward currents in resting conditions by 30%, an effect mimicked by catalase alone. In conclusion, the present results seem to suggest that changes in ROS production can specifically influence K+ currents carried by the HERG channels.
Characteristics of a slot‐couped microstrip antenna using high‐permittivity feed substrate (1995)

Abstract The slot‐coupled microstrip antenna can be used for constructing a thin and lightweight active antenna without a feed loss by electromagnetic coupling of such active circuits as MIC and MMIC on the back side directly with the radiating element via the slot. Hence, this structure is promising as a highly functional mobile communication antenna. In this case, the feed substrate has a high dielectric constant as MIC and MMIC and are used while the antenna substrate has a low dielectric constant so that a large bandwidth and a high radiation efficiency can be obtained. It is important for the design of active devices to understand various characteristics of the present antenna constructed from substrates with different dielectric constants. In this paper, the effect of the dielectric constant of the feed substrate on various antenna characteristics is derived both by measurement and by computation using the spatial network method. It is found that the resonant frequency changes if a high dielectric consant material is used, although the amount of change is less than the relative bandwidth and that the relative bandwidth of the antenna does not depend on the dielectric constant of the feed substsrate. When an MIC or an MMIC is attached to the back side, the radiation from the feed line including the slot to the back side is coupled directly with the active device and causes intermodulation. the effect of the dielectric constant of the feed substrate on the back‐side radiation is an indispensable item of investigation for development of active antennas. This investigation also is carried out in this paper which deals with the effect of the dielectric constant on the backside radiation.
Revision Anterior Cruciate Ligament Reconstruction with Hamstring Tendon Autograft (2006)

Revision anterior cruciate ligament reconstruction with hamstring tendon graft and interference screw fixation affords acceptable results at a minimum of 5 years' follow-up. Good objective results can be obtained, but subjectively, the results appear inferior to those of primary anterior cruciate ligament reconstruction in the literature, which may be related to the high incidence of articular surface damage in this patient population. We recommend that, when available, hamstring tendon autografts should be considered for revision anterior cruciate ligament reconstruction.
Phosphate Starvation Triggers Distinct Alterations of Genome Expression in Arabidopsis Roots and Leaves (2003)

Arabidopsis genome expression pattern changes in response to phosphate (Pi) starvation were examined during a 3-d period after removal of Pi from the growth medium. Available Pi concentration was decreased after the first 24 h of Pi starvation in roots by about 22%, followed by a slow recovery during the 2nd and 3rd d after Pi starvation, but no significant change was observed in leaves within the 3 d of Pi starvation. Microarray analysis revealed that more than 1,800 of the 6,172 genes present in the array were regulated by 2-fold or more within 72 h from the onset of Pi starvation. Analysis of these Pi starvation-responsive genes shows that they belong to wide range of functional categories. Many genes for photosynthesis and nitrogen assimilation were down-regulated. A complex set of metabolic adaptations appears to occur during Pi starvation. More than 100 genes each for transcription factors and cell-signaling proteins were regulated in response to Pi starvation, implying major regulatory changes in cellular growth and development. A significant fraction of those regulatory genes exhibited distinct or even contrasting expression in leaves and roots in response to Pi starvation, supporting the idea that distinct Pi starvation response strategies are used for different plant organs in response to a shortage of Pi in the growth medium.
ChemInform Abstract: Synthetic Carbohydrate Derivatives as Low Sulfated Heparin Mimetics. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The effect of immaturity of the calf on immunological responses to strain 19 and killed 45/20 adjuvant vaccines (1977)

Thirty brucellosis free calves with zero titres to the serum agglutination test (SAT), complement fixation test (CFT) and antiglobulin test (ABGT) were vaccinated with strain 19 at ages from seven hours to 198 days. Calves 75 days of age and older responded with normal serological patterns, developing high titres to all three tests. At 45 days and younger most calves responded with much reduced titres, some were negative to the SAT and CFT but all develped titres to the ABGT. Two of the younger group were subjected to an anamnestic test at about a year old and gave a positive response, indicating that the calf may be effectively primed with S19 as early as the first day of life. Three of the group were colostrumdeprived yet the patterns of their responses were similar to those of the colostrum-fed calves. Seventy-four zero titres calves were vaccinated with killed 45/20 adjuvant vaccine at ages from 60 to 320 days. Up to 200 days of age only seven of 33 calves gave positive response. From 200 to 280 days 18 of 29 responded and from 280 days of age all calves a positive response. The late development of competence to respond to this adjuvant vaccine is somewhat unusual and is discussed. It is suggested that the rough strain 45/20 may be a very weak antigen in cattle.
Intravenous Antibiotics in Preterm Infants have a Long-Term Negative Effect upon Microbiome Development Throughout Preterm Life – an observational study (2022)

Abstract Intestinal dysbiosis is implicated in the origins of necrotising enterocolitis and late-onset sepsis in preterm babies. However, the effect of modulators of bacterial growth ( e . g . antibiotics) upon the developing microbiome is not well-characterised. Using high-throughput 16S rRNA gene sequencing combined with contemporaneous clinical data collection, the within-subject relationship between antibiotic administration and microbiome development was assessed, in comparison to preterm infants with minimal antibiotic exposure. During courses of antibiotics, diversity progression fell in comparison to that seen outside periods of antibiotic use (−0.71units/week vs . +0.63units/week, p&lt;0.01); Enterobacteriaceae relative abundance progression conversely rose (+10.6%/week vs . -8.9%/week, p&lt;0.01). After antibiotic cessation, diversity progression remained suppressed (+0.2units/week, p=0.02). Antibiotic use has an acute and longer-lasting impact on the developing preterm intestinal microbiome. This has clinical implications with regard to the contribution of antibiotic use to evolving dysbiosis, and affects the interpretation of existing microbiome studies where this effect modulator is rarely accounted for.
Enhancement of Xen's scheduler for MapReduce workloads (2011)

As the trends move towards data outsourcing and cloud computing, the efficiency of distributed data centers increases in importance. Cloud-based services such as Amazon's EC2 rely on virtual machines (VMs) to host MapReduce clusters for large data processing. However, current VM scheduling does not provide adequate support for MapReduce workloads, resulting in degraded overall performance. For example, when multiple MapReduce clusters run on a single physical machine, the existing VMMscheduler does not guarantee fairness across clusters.
Human neural crest cells contribute to coat pigmentation in interspecies chimeras after in utero injection into mouse embryos (2016)

The neural crest (NC) represents multipotent cells that arise at the interphase between ectoderm and prospective epidermis of the neurulating embryo. The NC has major clinical relevance because it is involved in both inherited and acquired developmental abnormalities. The aim of this study was to establish an experimental platform that would allow for the integration of human NC cells (hNCCs) into the gastrulating mouse embryo. NCCs were derived from pluripotent mouse, rat, and human cells and microinjected into embryonic-day-8.5 embryos. To facilitate integration of the NCCs, we used recipient embryos that carried a c-Kit mutation (W(sh)/W(sh)), which leads to a loss of melanoblasts and thus eliminates competition from the endogenous host cells. The donor NCCs migrated along the dorsolateral migration routes in the recipient embryos. Postnatal mice derived from injected embryos displayed pigmented hair, demonstrating differentiation of the NCCs into functional melanocytes. Although the contribution of human cells to pigmentation in the host was lower than that of mouse or rat donor cells, our results indicate that hNCCs, injected in utero, can integrate into the embryo and form mature functional cells in the animal. This mouse-human chimeric platform allows for a new approach to study NC development and diseases.
Comparative analysis of state-level concussion legislation and review of current practices in concussion (2012)

Injury prevention legislation holds historical precedent, and given the increasing attention to long-term sequelae of repeated head trauma and concussion, concussion legislation has been rapidly passed in 43 states and the District of Columbia. Although the exact stipulations of these laws vary among states, the overall theme is to increase recognition of concussion in young athletes and ensure that they are appropriately cleared for return to play after concussion.
The unusual mechanism of action of the microtubule targeted drug curacin A (2004)

5412 Curacin A, isolated from the blue green alga Lyngbya majescula, has potent anti-proliferative activity. Curacin A binds with high affinity to the colchicine binding site as well as to at least two other low affinity binding sites on tubulin. Additionally, curacin A potently inhibits polymerization of microtubules in vitro and inhibits proliferation of L1210 leukemia and CA46 Burkitt cells. We found that low concentrations of curacin A (10 nM) inhibited HeLa cell proliferation by 50 % (IC50) without inducing mitotic block. By flow cytometry of cellular DNA content, low concentrations of curacin A appear to slow the cell cycle. At high concentrations (≥50 nM) cell proliferation was inhibited by 100% with approximately 80% of the cells blocked in mitosis. At the IC50 for proliferation, interphase microtubules were significantly depolymerized and the cells progressed through the cell cycle more slowly than control cells. Using the FAM FLICA caspase activation assay, we examined the ability of curacin A (10-100 nM) to activate caspases and induce apoptosis. With 100 nM curacin A, the percentage of cells with activated caspases increased by 14 -100 % after incubation with curacin A for 20-72 h, respectively. Thus at low concentrations, curacin A appears to slow the cell cycle and inhibit cell proliferation by a unique depolymerizing effect on interphase microtubules. This effect is in contrast to the effects of many chemotherapeutic microtubule-active drugs that act primarily to inhibit cell proliferation by blocking mitosis. Given its microtubule-depolymerizing effects at low concentrations and its similarity to other vascular-targeting agents that bind to the colchicine site, curacin A may have potential as an anti-vascular agent. Supported by NIH CA57291 and NS13560.
Multiparameter Sensor Based on Single High-Order Fiber Bragg Grating Made With IR-Femtosecond Radiation in Single-Mode Fibers (2008)

Narrowband multiple high-order Bragg resonances from a single Bragg grating structure inscribed using a femtosecond IR laser and a 4.28 mum pitched phase mask are used to demonstrate a multiparameter sensor in standard low cutoff wavelength optical fiber. Six high reflectivity resonances that are observed in the wavelength range from 1 to 2 mum can be used to monitor up to six sensing parameters. Temperature and strain coefficients of the grating at each of the high-order Bragg resonances are evaluated.
A new method for strictness analysis on non-flat domains (2003)

The authors address the problem of strictness analysis, particularly in the case of non-flat domains, i.e., lazily evaluated lists. Their approach to this problem is novel in that it is based on an abstract domain of very general necessity patterns which allow the requirements that a function has for the components of the data structures which form its arguments, to be modeled in great detail. The necessity patterns also allow the generation of finite abstract domains in a systematic way that can be easily customized for the application. The authors refer to the analysis using necessity patterns as a necessity analysis. This is essentially a form of backwards analysis but carried out in a different framework.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
[From farm to fork--Mycobacterium avium ssp. paratuberculosis (MAP) as zoonotic agent?]. (2005)

Mycobacterium avium ssp. paratuberculosis (MAP) is the causative agent of the paratuberculosis (Para Tb) in ruminants. In addition, this pathogen has been suspected to be implicated in the pathogenesis of Morbus Crohn disease (MC), causing chronic inflammatory intestine changes of humans. The participation of MAP in this illness is discussed intensively and has very contradictory opinions. On the one hand several times succeeded in proving MAP DNA in changed human tissues as well as, in recent time, the bacteria has been isolated from patient's blood. On the other hand there are many publications which support the opposite opinion. In critical evaluation of already available data, therefore the hypothesis can be formulated that MAP could possibly take part in the MC of humans. The reliable verification of this hypothesis will only be possible, if the diagnostic procedures can be refined upon the substantial deficit concerning the sensitivity and/or specificity of the diagnostic methods. In addition, till now there is lack of optimized statistically case control studies. The conceivable transmission of the bacteria to humans by the direct animal contact has been considered as possible vector, furthermore, MAP has been detected in pasteurised milk and other food of animal origin. The prevalence data, usually estimated by ELISA for milk cattle stock show over 80% prevalence in many counties of the Federal Republic of Germany with an individual case prevalence ranging between 1% and 17% in different stocks. Comparable data are present also from other countries as well as for small ruminants. MAP has been concerned as a global problem, moreover the high spreading rate of MAP in wild animal populations as well as the considerable ability of the bacteria to survive in different stages of the infectious- and contamination-cycle, which might hardly be broken through. Thus it requires intensive research efforts for the development of the methodical diagnostic process as basis for valid epidemiological investigations of animals, humans and food.