gebhart/patrepeval huggingface dataset:
Atomistic mechanisms of cyclic hardening in metallic glass (2012)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Chuang Deng, Christopher A. Schuh; Atomistic mechanisms of cyclic hardening in metallic glass. Appl. Phys. Lett. 18 June 2012; 100 (25): 251909. https://doi.org/10.1063/1.4729941 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioApplied Physics Letters Search Advanced Search |Citation Search
Standardizing And Democratizing Access To Cancer Molecular Diagnostic Test Data From Patients To Drive Translational Research. (2018)

In the last 3-5 years, there has been a rapid increase in clinical use of next generation sequencing (NGS) based cancer molecular diagnostic (MolDx) testing to develop better treatment plans with targeted therapies. To truly achieve precision oncology, it is critical to catalog cancer sequence variants from MolDx testing for their clinical relevance along with treatment information and patient outcomes, and to do so in a way that supports large-scale data aggregation and new hypothesis generation. Through the NIH-funded Clinical Genome Resource (ClinGen), in collaboration with NLM's ClinVar database and >50 academic and industry based cancer research organizations, a Minimal Variant Level Data (MVLD) framework to standardize reporting and interpretation of drug associated alterations was developed. Methodological and technology development to standardize and map MolDx data to the MVLD standard are presented here. Also described is a novel community engagement effort through disease-focused taskforces to provide usecases for technology development.
Controlling the G-Quadruplex Topology: Toward the Formation of a Lipid Thrombin Binding Aptamer Prodrug (2023)

Important efforts have been devoted toward the development of modified oligonucleotides capable of controlling the secondary structures of the G-quadruplex (G4). Herein, we introduce a photocleavable, lipidated construct of the well-known Thrombin Binding Aptamer (TBA) whose conformation can be dual-controlled by light and/or the ionic strength of the aqueous solution. This novel lipid-modified TBA oligonucleotide spontaneously self-assembles and switches from the conventional antiparallel aptameric fold at low ionic strength to the parallel, inactive conformation of the TBA oligonucleotide strands under physiologically relevant conditions. The latter parallel conformation can be readily and chemoselectively switched back to the antiparallel native aptamer conformation upon light irradiation. Our lipidated construct constitutes an original prodrug of the original TBA with properties that are prone to improving the pharmacodynamic profile of the unmodified TBA.
<sup>89</sup>Zr-Nanocolloidal Albumin–Based PET/CT Lymphoscintigraphy for Sentinel Node Detection in Head and Neck Cancer: Preclinical Results (2011)

(89)Zr-nanocolloidal albumin is a promising tracer for sentinel node detection by PET.
ParaGraph: Layout Parasitics and Device Parameter Prediction using Graph Neural Networks (2020)

Layout-dependent parasitics and device parameters significantly impact integrated circuit performance and are often the cause of slow convergences between schematic and layout designs. Circuit designers typically estimate parasitics from past experience, resulting in variability between designers and the potential for inaccuracies. In this paper, we present ParaGraph: a graph neural network model to predict net parasitics and device parameters by converting circuit schematics into graphs and leveraging key modeling techniques based on GraphSage, Relation GCN and Graph Attention Networks. Furthermore, the use of ensemble modeling increases model accuracy over a large range of prediction values. Trained on a large dataset of industrial circuits, the model achieves an average prediction R <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> of 0.772 (110% better than XGBoost) and reduces average simulation errors from over 100% with designer's estimation to less than 10%.
Regulation of α Genes of Herpes Simplex Virus: The α 27 Gene Promoter-Thymidine Kinase Chimera Is Positively Regulated in Converted L Cells (1982)

In cells infected with herpes simplex virus 1, the expression of viral genes is coordinately regulated and sequentially ordered; the alpha genes are expressed first and are followed by beta and gamma genes in a cascade fashion. Earlier, this laboratory reported (Post et al., Cell 24:555-565, 1981) that a chimeric gene, constructed by the replacement of 50 base pairs of DNA coding for 5' nontranslated leader and sequences upstream of the site of transcription initiation of thymidine kinase (a beta gene) by corresponding sequences of alpha gene no. 4, was regulated as an alpha gene. Of particular interest was the observation that in cells converted to TK(+) phenotype, the chimeric gene was positively regulated by superinfecting virus. In this paper, we report two series of experiments. First, we determined that transcription of alpha gene no. 27 is initiated at or near a five-nucleotide sequence flanked by an eight-nucleotide perfect inverted repeat situated from 256 to 277 bases to the right of the left terminus of the BamHI B fragment. In the second series of experiments, we constructed a chimeric gene which consisted of the thymidine kinase sequences described above but was fused to a DNA fragment expected to contain the promoter-regulatory region of alpha gene 27 and stretching from approximately -270 to the +55 nucleotide. The chimeric gene in converted cells was amplified upon superinfection with TK(-) virus only when the promoter-regulatory region was in the correct transcriptional orientation relative to the leader and structural sequences of the thymidine kinase gene. The requirements for amplification of the expression of this chimeric thymidine kinase gene were exactly the same as those previously reported for the alpha gene no. 4-thymidine kinase chimera and different from those of the standard (beta) thymidine kinase. We conclude that the positive regulation of expression of alpha gene no. 4 deduced in previous studies may be a general property of alpha genes and that the promoter-regulatory region of alpha gene no. 27 is within a sequence contained between -270 and +55 nucleotides relative to the transcription initiation site.
A 18.6 GHz locking range, 60 GHz band varactor-tuned injection locked frequency divider in 65 nm CMOS (2017)

A 60 GHz band injection locked tunable dynamic frequency divider has been developed in 65 nm CMOS. By varying the bias voltage of varactor diodes in LC tank circuit of the dynamic divider, the fabricated CMOS RFIC performs the widest operational frequency range of 18.6 GHz (relative bandwidth of 34.5 %) at VDD = 1 V and the highest FoM at VDD = 0.5 V in 60 GHz band.
RISK FACTORS AND CHANGES IN SEXUAL BEHAVIOR IN MALE HOMOSEXUALS WHO SEROCONVERTED FOR HUMAN IMMUNODEFICIENCY VIRUS ANTIBODIES (1990)

In Amsterdam, The Netherlands, a cohort of 982 homosexual and bisexual men has been studied since 1984. Of these, 238 men had antibodies to the human immunodeficiency virus at the onset of the study, and 84 men seroconverted while under study. For each of these seroconversions, two participants who remained seronegative were chosen for comparison, taking the seroconversion date as a reference. This offered an opportunity to study any changes that may have occurred longitudinally, i.e., over time. Risk factors for seroconversion were studied along with changes in sexual behavior relative to the moment of seroconversion. The number of different partners in anogenital receptive intercourse and a history of syphilis or anogenital herpes simplex were found to be predictors for human immunodeficiency virus seroconversion. The data suggest that, prior to seroconversion, there is a peak in riskful sexual behavior and that the "decline" often observed immediately after seroconversion is, in fact, an indication of a return to "normal" sexual activity.
Microscopic Approach to Craniosynostosis (2005)

The purpose of this study is to describe a minimally invasive approach using a microscope and the subsequent helmet therapy. The authors have treated 14 patients with the microscopic technique between May 2001 and November 2003. In this group of patients, there were 3 females and 11 males with an average age of 10.5 weeks and a range of 4 to 28 weeks. The study included 8 patients with sagittal synostosis and 6 patients with other synostoses. In the latter group, there were 3 patients with metopic, one with unicoronal, one with bicoronal, and one with lambdoidal. The approach used limited incisions over the affected sutures. The craniotomy/craniectomy was completed using a 5-mm burr. Postoperative helmet therapy was begun within 2 weeks after surgery. In patients with sagittal synostosis, a mean of 1.5 helmets for a duration of 11.4 weeks was used. In the other groups of patients with craniosynostosis, a mean of 2.3 helmets for a duration of 13.5 weeks was used. A microscopic variation to the "minimally invasive" approach to craniosynostosis is presented. It provides excellent visualization, illumination, and control of the surgical field. When compared with traditional surgery, it results in shorter hospitalization and operative time and decreased blood loss. The authors note that critical to this approach is the postoperative helmet therapy. Early results are encouraging.
Roles of and Histidine 752 and Glutamate 699 in the pH Dependence of Mouse Band 3 Protein-Mediated Anion Transport (1995)

In the accompanying paper we have shown that four different histidine residues are involved in the maintenance of mouse band 3 in a state in which it is able to execute its anion transport function. Here we focus on the functional significance of His 752 and demonstrate that this residue, together with Glu 699, plays a key role in the control of pH dependence of Cl- transport. Mouse band 3-encoding cRNA was expressed in Xenopus oocytes, and band 3-mediated Cl- transport was measured at zero membrane potential over the pH range 6.0-9.2. Transport decreased with increasing H+ concentration and was governed by a single pK of 5.8. After correction for temperature differences, this result agrees well with measurements in erythrocyte ghosts of Cl- flux by Funder and Wieth [Funder, J., & Wieth, J. O. (1976) J. Physiol. 262, 679-698] and our own determinations by 35Cl NMR spectroscopy of Cl- exchange between the substrate binding site and the medium. After mutation of either Glu 699 to Asp or of His 752 to Ser, the maximal rate of transport is reduced and the rate of anion exchange is now governed by a single pK of about 6.8-6.9. This suggests that the formation of a hydrogen bond between His 752 and Glu 699 is essential for the decrease of band 3-mediated Cl- transport at low pH. We suggest that in the wild type band 3 both the decrease of the chloride exchange between the medium and the substrate binding site and the inhibition of chloride translocation across the membrane are dominated by a common rate-limiting step and that this step involves hydrogen bond formation between Glu 699 and His 752.
Complex band structure and the band alignment problem at the Si–high-<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>k</mml:mi></mml:math>dielectric interface (2005)

We investigate the use of the complex band structure of high-$k$ gate dielectrics to estimate their charge neutrality levels, and compute band offsets to Si. A comparison is made with the available results obtained with direct electronic structure methods and experiment. It appears that charge neutrality levels thus obtained indeed provide a consistent picture for simple interfaces. However, the uncertainty in the conduction band position inherent in the local density approximation may render the theory inadequate for engineering support. Despite this limitation, linear rescaling of the charge neutrality levels based on the experimental band gaps for six oxides (${\mathrm{SiO}}_{2}$, ${\mathrm{Al}}_{2}{\mathrm{O}}_{3}$, $c\text{\ensuremath{-}}{\mathrm{HfO}}_{2}$, $m\text{\ensuremath{-}}{\mathrm{HfO}}_{2}$, ${\mathrm{La}}_{2}{\mathrm{O}}_{3}$, and ${\mathrm{SrTiO}}_{3}$) has shown excellent agreement with experimental data.
Combined arsenic trioxide and all‐<i>trans</i> retinoic acid treatment for acute promyelocytic leukaemia recurring from previous relapses successfully treated using arsenic trioxide (2002)

The optimal treatment of acute promyelocytic leukaemia (APL) recurring from relapses successfully treated using arsenic trioxide (As2O3) is undefined. Three APL patients relapsing from As2O3-induced remission were studied. Re-treatment with As2O3 failed in one patient in third relapse, and resulted in morphological but not molecular remission in another patient. Combination therapy with As2O3 and all-trans retinoic acid (ATRA), however, resulted in morphological and molecular remission in all three cases, with a follow-up time ranging from 6 to 16 months. Our results suggest a synergistic therapeutic effect between As2O3 and ATRA in APL in advanced relapse.
Chemically Prepared Magnetic Nanoparticles (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Preparation and characterization of<i>Antheraea assama</i>silk fibroin based novel non-woven scaffold for tissue engineering applications (2009)

The quest for novel materials as scaffolds with suitable micro-architecture for supporting tissue neogenesis in tissue engineering and regenerative medicine (TERM) is continuing. In this paper we report an Antheraea assama silk-based non-woven fibroin scaffold for applications in TERM. The novel three-dimensional scaffold is highly interconnected and porous, with a pore size of 150 microm, porosity of 90% and water uptake capacity of 85%. FTIR revealed a typical beta-sheet structure of fibroin. The scaffold has thermal and mechanical properties superior to those of Bombyx mori, as revealed by DSC, TGA and tensile tests. The scaffold exhibited satisfactory blood compatibility, as determined by thrombogenicity, haemolysis, platelet/leukocyte count, platelet adhesion and protein adsorption studies. The scaffold was found to be cytocompatible with human cell lines A549, KB, HepG2 and HeLa for a period of up to 4 weeks. SEM analysis revealed excellent attachment, spreading and migration of cells in the scaffold. MTT assay was performed to estimate the viability and growth of cells in the matrix. Quantification of collagen in cell-scaffold constructs was done by picro-Sirius red assay. Ex ovo chorioallantoic membrane assay and nitric oxide estimations in spent culture medium showed the scaffold's ability to promote angiogenesis. Finally, the biodegradability of the scaffold was determined by the weight loss observed upon treatment with trypsin over a period of 4 weeks. The results reveal that the fibroin from A. assama is a promising candidate as a biocompatible, biomimetic and biodegradable biomaterial of natural origin for applications in TERM.
A Combination of Different Polymerase Chain Reaction (PCR) Assays for the Presumptive Identification of <i>Yersinia pestis</i> (2000)

A combination of four polymerase chain reaction (PCR) assays targeting the Yersinia pestis-specific plasmoidal genes of the fraction 1 capsular antigen and plasminogen activator/coagulase, the gene of the V antigen of the Yersinia virulence plasmid, and the chromosomal 16S rRNA gene was evaluated for the identification of Y. pestis isolates. All four assays were subjected to the same sample preparation technique, reagents and cycling conditions. Eighteen Y. pestis, 66 Y. pseudotuberculosis, 40 Y. enterocolitica strains, the type strains of the other Yersinia species, and 20 other pathogenic bacterial strains were investigated. By using the proposed combination of PCR assays all Y. pestis strains were identified correctly. The applicability of this combination of PCR assays was demonstrated by the detection of Y. pestis DNA in spiked tissues from Rattus norwegicus and fleas (Xenopsylla cheopis and Ctenocephalides spp.). As little as 60 genome equivalents were detected. This system is applicable for monitoring Y. pestis and its vectors in enzootic natural foci and in the diagnosis of plague in humans and animals.
Cationic polymerization of isoprene using zinc halides as co‐initiators: towards well‐defined oligo(isoprene)s under mild conditions (2012)

Abstract The activity of ZnX 2 ‐based initiating systems (X = Cl, Br, I) in the cationic polymerization of isoprene was studied. The highest activity was achieved when co‐initiator ( ZnX 2 ) was solubilized in a minimal amount of strongly coordinating solvent such as diethyl ether or acetone and when trichloroacetic acid was used as an initiator. It is shown that the polymerization rate increased in the series ZnI 2 &lt; ZnCl 2 &lt; ZnBr 2 . An increase of initiator concentration and temperature also led to an increase of the polymerization rate. The obtained polyisoprenes did not contain high‐molecular‐weight and insoluble fractions and were characterized by low number‐average molecular weight and relatively narrow molecular weight distribution. Unsaturation of polyisoprene decreased with an increase of monomer conversion and reaction temperature. The unsaturated part of the polyisoprene chain possessed predominantly 1,4‐ trans microstructure with regular and inverse addition, whereas the 1,2‐ and 3,4‐isomers were present as minor components. It is shown that the synthesized low‐molecular‐weight polyisoprenes are effective plasticizers for rubber compounds in the manufacture of tyres. © 2012 Society of Chemical Industry
Primary structure of <i>cryX</i><sup>1</sup>, the novel δ‐endotoxin‐related gene from <i>Bacillus thuringiensis</i> spp. <i>galleriae</i> (1993)

A cry-related sequence, designated cryX (EMBL X75019), was localized upstream of cryIG, the delta-endotoxin gene cloned from spp. galleriae of Bacillus thuringiensis and sequenced earlier [(1991) FEBS Lett. 293, 25-28]. Analysis of the cryX complete nucleotide sequence enabled us to explain its virtual crypticity and to reveal the chimeric structure of the genes, cryX and cryIG. The amino acid sequence of 1,151 residues encoded by the continuous reading frame of cryX is similar to the other delta-endotoxins but differs essentially from them.
Synthesewege zu polyfunktionellen Molekülen über metallierte Dimethylhydrazone (1978)

Abstract Reaktionen von metallierten Dimethylhydrazonen (DMH's) 3 mit Elektrophilen, wie gesättigten und α‐β‐ungesättigten Carbonylverbindungen und Oxiranen. werden zu regiospezifischen CC‐Verknüpfungen in α‐Stellung zur Carbonylgruppe ausgenutzt. Oxidative Hydrolyse der resultierenden Produkthydrazone 4 , 8 , 14 , 23 führt zu synthetisch wertvollen, polyfunktionellen Molekülen. Die hohe Effektivität und Selektivität der Methode wird an einer Vielzahl von Beispielen, wie regiospezifischen Aldol‐Reaktionen (→ 5 , 7 ), der Darstellung von γ‐Hydroxycarbonyl‐ 9 , 10 , 1,4‐ 11 , 12 und 1,5‐Dicarbonylverbindungen 15 – 18 (regiospezifische Robinson‐Anellierung 19 , DMH‐Cuprate 13 ), Carbonylolefinierungen zu α,β‐ungesättigten Aldehyden 20 über α‐silylierte DMH's 21 sowie der regiospezifischen γ‐Funktionalisierung von Crotonaldehyd‐DMH demonstriert (→ 25 ). Doppelt metalliertes Acetessigsäure‐methylester‐DMH ( 27 ) reagiert mit Carbonylverbindungen zu 5,6‐Dihydro‐α‐pyron‐Derivaten 28 , die zu Hydroxyketo‐carbonsäuren 29 hydrolysiert werden können.
Novel membrane technology for green ethylene production. (2008)

If hallucinations are experienced during or after a period of alcohol abuse, the diagnosis of alcohol hallucinosis should be considered. The diagnosis must be distinguished from delirium tremens and schizophrenia spectrum disorder as treatment and prognosis are essentially different.
Synthesis, characterization, and nucleophilic substitution-addition reactions of manganese-oxapentadienyl compounds. Structural characterization of [cyclic] (.eta.5-CH2CHCHCOCH3)Mn(CO)2L (L = CO, PPH3) and the first isolation of novel .eta.5-1-azapentadienyl complexes (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthesis, characterization, and nucleophilic substitution-addition reactions of manganese-oxapentadienyl compounds. Structural characterization of [cyclic] (.eta.5-CH2CHCHCOCH3)Mn(CO)2L (L = CO, PPH3) and the first isolation of novel .eta.5-1-azapentadienyl complexesMing Huei Cheng, Chih Yi Cheng, Sue Lein Wang, Shie Ming Peng, and Rai Shung LiuCite this: Organometallics 1990, 9, 6, 1853–1861Publication Date (Print):June 1, 1990Publication History Published online1 May 2002Published inissue 1 June 1990https://pubs.acs.org/doi/10.1021/om00156a026https://doi.org/10.1021/om00156a026research-articleACS PublicationsRequest reuse permissionsArticle Views116Altmetric-Citations15LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
Parametric Analysis and Optimization of Vanillin Hydrodeoxygenation Over a Sulfided Ni-Mo/δ-Al2O3 Catalyst Under Continuous-Flow Conditions (2022)

Abstract A fundamental understanding of the process parameters affecting the catalytic hydrodeoxygenation (HDO) of bio-oils is of significance for enabling further progression and improvement of industrial biofuel upgrading methods. Herein, a novel demonstration and evaluation of the effect of temperature, pressure, and weight hourly space velocity in the continuous HDO of vanillin to cresol over a Ni-Mo/δ-Al 2 O 3 catalyst are presented. Response surface methodology was used as a statistical experimental design method, and the application of central composite design enabled the generation of a statistically significant simulation model and a true optimization parametric study. The distribution of Ni and Mo on δ-Al 2 O 3 was confirmed using scanning electron microscopy with energy dispersive X-ray analysis (SEM-EDX). No gradients with EDX mapping could be identified, and the elemental analysis showed well-dispersion of the metals. The mesoporous character of the catalyst-support system was unraveled using N 2 physisorption. Experiments were conducted within the parametric range of 250–350 °C, 3–9 bar, and 15–35 h −1 . Both temperature and pressure were found to have statistically significant linear and quadratic effects on the selectivity for cresol. The parametric interaction of temperature with pressure and space velocity also had a significant effect on the resulting response. The optimal temperature range becomes more critical at lower space velocities. Optimal selectivity for cresol was established at 314 °C, 5 bar, and 35 h −1 . The fitting quality of the generated regression model was statistically confirmed and experimentally validated to describe the specified HDO process within the 95% two-sided confidence interval.