gebhart/patrepeval huggingface dataset:
Prevalence of Venous Thromboembolism In Patients with Secondary Polycythemia (2010)

Abstract Abstract 3164 Background: Polycythemia vera is associated with an increased risk for venous thromboembolism (VTE). Although phlebotomy is employed as an adjunct to treatment with hydroxyurea and/or aspirin for VTE risk reduction, emerging data suggest that hematocrit is less of a determinant of VTE risk than leukocyte count and JAK2 V617F gene mutation allele burden. The role of secondary polycythemia as a risk factor for VTE is unknown, but phlebotomy for thrombosis risk reduction is frequently practiced. Based on the polycythemia vera model, however, we hypothesize that secondary polycythemia does not increase VTE risk. The purpose of this study was to determine the prevalence of VTE in patients with secondary polycythemia and to investigate the factors associated with VTE in this population. Methods: We performed a case control study that included patients admitted to Dartmouth-Hitchcock Medical Center with a diagnosis of chronic obstructive pulmonary disease (COPD) and a hematocrit greater than or equal to 50% from August 2004 to July 2009. The controls were matched for age and sex and carried a diagnosis of chronic obstructive pulmonary disease (COPD) without evidence of secondary polycythemia. Data were collected on body mass index (BMI), VTE history, comorbid conditions, thrombophilia and smoking history. Clinical characteristics of patients with and without secondary polycythemia were analyzed using chi square and t-test to evaluate for significant differences in the two populations. Results: Eighty-six patients with secondary polycythemia and 86 controls were included in the study. The mean hematocrit was 53.5% in the case group and 43.7% in the control group (p=&lt;0.005). Among cases, a history of VTE was documented in 17/86 (19.8%), 10 of which (58.8%) were judged to be idiopathic. In the control group, VTE was documented in 12/86 (14%), 4 of which (33.3%) were judged to be idiopathic. There was no statistically significant difference in the number of total (OR=1.52, p=0.42) or idiopathic (OR=2.7; p=0.16) VTE between cases and controls, respectively. There were no statistically significant differences noted in age, sex, body mass index, presence of diabetes mellitus, smoking history or the presence of malignancy in the two groups. Patients with VTE in both groups had higher BMI, however, compared to patients without VTE. Conclusions: We did not observe an increased prevalence of VTE in patients with secondary polycythemia compared to age- and sex-matched controls. Our findings suggest that the high prevalence of VTE observed in patients with secondary polycythemia is more likely related to known risk factors such as obesity rather than hyperviscosity due to increased cell mass. The role of phlebotomy for VTE risk reduction in patients with secondary polycythemia is therefore questionable. Disclosures: No relevant conflicts of interest to declare.
Silica Shells/Adhesive Composite Film for Color Doppler Ultrasound Guided Needle Placement (2017)

Ultrasound (US) guided medical devices placement is a widely used clinical technology, yet many factors affect the visualization of these devices in the human body. In this research, an ultrasound-activated film was developed that can be coated on the surface of medical devices. The film contains 2 μm silica microshells and poly(methyl 2-cyanoacrylate) (PMCA) adhesive. The air sealed in the hollow space of the microshells acted as the US contrast agent. Ozone and perfluorooctyltriethoxysilane (PFO) were used to treat the surface of the film to enhance the US signals and provide durable antifouling properties for multiple passes through tissue, consistent with the dual oleophobic and hydrophobic nature of PFO. In vitro and in vivo tests showed that hypodermic needles and tumor marking wires coated with US activated film gave strong and persistent color Doppler signals. This technology can significantly improve the visibility of medical devices and the accuracy of US guided medical device placement.
Pain perception is altered by a nucleotide polymorphism in <i>SCN9A</i> (2010)

The gene SCN9A is responsible for three human pain disorders. Nonsense mutations cause a complete absence of pain, whereas activating mutations cause severe episodic pain in paroxysmal extreme pain disorder and primary erythermalgia. This led us to investigate whether single nucleotide polymorphisms (SNPs) in SCN9A were associated with differing pain perception in the general population. We first genotyped 27 SCN9A SNPs in 578 individuals with a radiographic diagnosis of osteoarthritis and a pain score assessment. A significant association was found between pain score and SNP rs6746030; the rarer A allele was associated with increased pain scores compared to the commoner G allele (P = 0.016). This SNP was then further genotyped in 195 pain-assessed people with sciatica, 100 amputees with phantom pain, 179 individuals after lumbar discectomy, and 205 individuals with pancreatitis. The combined P value for increased A allele pain was 0.0001 in the five cohorts tested (1277 people in total). The two alleles of the SNP rs6746030 alter the coding sequence of the sodium channel Nav1.7. Each was separately transfected into HEK293 cells and electrophysiologically assessed by patch-clamping. The two alleles showed a difference in the voltage-dependent slow inactivation (P = 0.042) where the A allele would be predicted to increase Nav1.7 activity. Finally, we genotyped 186 healthy females characterized by their responses to a diverse set of noxious stimuli. The A allele of rs6746030 was associated with an altered pain threshold and the effect mediated through C-fiber activation. We conclude that individuals experience differing amounts of pain, per nociceptive stimulus, on the basis of their SCN9A rs6746030 genotype.
Performance limits of guided-wave devices for space applications (1997)

In this paper some significant developments of guided-wave devices and recent technological advances in optoelectronics for space are described. The performance limits of these devices are highlight in terms of technological problems, power consumption, operating frequency, sizes and weight.
Results of infertility investigations and follow-up among 312 infertile women and their partners in Kigali, Rwanda (2011)

The objectives of this study were to assess the outcome of infertility investigations and an 18-month follow-up of 312 infertile women and their partners in Rwanda. Between November 2007 and May 2009, an infertility research clinic was opened. Infertile couples received basic infertility investigations, the available treatment was provided and couples were followed up over an 18-month period. The infertility remained unexplained in 3%, was due to a female factor in 31%, due to a male factor in 16% or due to a combination of male and female causes in 50% of fully investigated couples (n = 224). A tubal factor was found in 69% of women, a male factor in 64% of men. Predictors for tubal infertility in women included a history of high-risk sexual behaviour, HIV infection and a history of sexually transmitted infection (STI) symptoms in the male partner. After 12-18 months of follow-up, 40 pregnancies (16%) had occurred in 244 women. Our study shows high rates of tubal and male factor infertility in Rwanda. Pregnancy rates were low after conventional therapy. In order to provide effective and affordable treatment for infertility in resource-poor countries the development of low-cost assisted reproductive technologies are needed.
Improved Performance of Gas-diffusion Biocathode for Oxygen Reduction (2012)

The current density of gas-diffusion biocathodes for the oxygen reduction in biofuel cells was successfully increased by adjusting the hydrophobicity of porous carbon electrodes and by adding small amount of non-ionic surfactant to enzyme solution to be used in the enzyme adsorption process. Optimization of the hydrophobicity was performed with non-glycoprotein cupper efflux oxidase as an electrocatalyst. Carbon slurry was prepared by mixing Ketjen black and polytetrafluoroethylene in 2-propanol at a weight ratio of 3:2. Carbon paper was modified with the slurry and dried at 60°C to remove the solvent. Addition of small amount of non-ionic surfactant such as Triton X-100 (about 0.01%) into the enzyme solution was very effective to adsorb the enzyme on the hydrophobic porous carbon surface. The proposed method is also effective for glycoprotein multi-copper oxidase to fabricate high performance gas-diffusion biocathode.
Semantic Learning Modifies Perceptual Face Processing (2008)

Face processing changes when a face is learned with personally relevant information. In a five-day learning paradigm, faces were presented with rich semantic stories that conveyed personal information about the faces. Event-related potentials were recorded before and after learning during a passive viewing task. When faces were novel, we observed the expected N170 repetition effect-a reduction in amplitude following face repetition. However, when faces were learned with personal information, the N170 repetition effect was eliminated, suggesting that semantic information modulates the N170 repetition effect. To control for the possibility that a simple perceptual effect contributed to the change in the N170 repetition effect, another experiment was conducted using stories that were not related to the person (i.e., stories about rocks and volcanoes). Although viewers were exposed to the faces an equal amount of time, the typical N170 repetition effect was observed, indicating that personal semantic information associated with a face, and not simply perceptual exposure, produced the observed reduction in the N170 repetition effect. These results are the first to reveal a critical perceptual change in face processing as a result of learning person-related information. The results have important implications for researchers studying face processing, as well as learning and memory in general, as they demonstrate that perceptual information alone is not enough to establish familiarity akin to real-world person learning.
Zur Reaktion von (CO)<sub>4</sub>FeP(R)Cl<sub>2</sub> mit Na<sub>2</sub>Cr<sub>2</sub>(CO)<sub>10</sub> / Reactions of (CO)<sub>4</sub>FeP(R)Cl<sub>2</sub> with Na<sub>2</sub>Cr<sub>2</sub>(CO)<sub>10</sub> (1986)

(CO) 4 FeP(R)Cl 2 reacts with Na 2 Cr 2 (CO) 10 to give the μ 3 RP capped trigonal heterom etallic closed cluster Fe(CO) 3 Cr(CO) 4 Cr(CO) 5 (μ 3 -PR)(1) as a major product. ACr(CO) 5 -derivative of a metal substituted phosphane [(μ 2 ( t BuPCl)Fe 2 (CO) 7 )( t BuPH)]Cr(CO) 5 (2) is obtained as a minor component. The analogous reaction with (CO) 4 FeP(Ph)Cl 2 only gives the known cluster Fe 3 (CO) 9 (μ 3 -PR) 2 (3), while (CO) 4 FeP(c-hexyl)Cl 2 results in 4, a pentacarbonylchromiumderivative of the diiron species Fe 2 (CO) 6 μ-(PR) 3 . Species o f this type, containing an Fe 2 (CO) 6 entity doubly bridged by μ 2 -PR entities, which are them selves linked by another PR-group, are obtained in a systematic high yield process by reacting Fe 2 (CO) 6 (μ 2 -RPH)2 with n-BuLi/TMEDA , RPCl 2 . For com pound identification, analytical and spectroscopic data as well as four X-ray analyses are presented.
Antigenicity of recombinant maltose binding protein-Mycobacterium avium subsp. paratuberculosis fusion proteins with and without factor Xa cleaving (2013)

Mycobacterium avium subsp. paratuberculosis causes Johne’s disease (JD) in ruminants. Proteomic studies have shown that M. avium subsp. paratuberculosis expresses certain proteins when exposed to in vitro physiological stress conditions similar to the conditions experienced within a host during natural infection. Such proteins are hypothesized to be ex- pressed in vivo, are recognized by the host immune system, and may be of potential use in the diagnosis of JD. In this study, 50 recombinant maltose binding protein (MBP)-M. avium subsp. paratuberculosis fusion proteins were evaluated using serum samples from sheep infected with M. avium subsp. paratuberculosis, and 29 (58%) were found to be antigenic. Among 50 fusion proteins, 10 were evaluated in MBP fusion and factor Xa-cleaved forms. A total of 31 proteins (62%) were found to be antigenic in either MBP fusion or factor Xa-cleaved forms. Antigenicity after cleavage and removal of the MBP tag was marginally enhanced.
Resolving Precursor Deligation, Surface Species Evolution, and Nanoparticle Nucleation during Palladium Atomic Layer Deposition (2013)

The synthesis of highly dispersed palladium nanoparticles on TiO2 surfaces from palladium hexafluoroacetylacetonate (Pd(hfac)2) was investigated using in situ infrared (IR) spectroscopy, in situ X-ray absorption spectroscopy (XAS), and in situ pair distribution function (PDF) measurements under practical atomic layer deposition conditions. Residual surface chlorine was found to directly participate in the transformation of organometallic compounds to nanoparticles. Deligation of the Pd(hfac)2, evolution of the surface species, and nucleation of the Pd nanoparticles were precisely resolved. This knowledge can help direct the future design of advanced heterogeneous catalysts from organometallic compounds.
Novel anticancer alkene lactone from<i>Persea americana</i> (2013)

The compound caused a stimulatory effect on non-tumorigenic MCF-12A cells with respect to cell adhesion while tumorigenic MCF-7 cells detached continuously. This is the first report on the anticancer effects of this class of compound.
Recent Improvements in Road Noise Control (2007)

&lt;div class="htmlview paragraph"&gt;In the recent years, reduction of engine noise as well as aerodynamic noise makes vehicle road noise predominant in numerous operating conditions. Fortunately, experimental and numerical improvements now allow a better understanding of road noise generation and propagation. This paper will focus on two specifics improvements related to this matter.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;First, excitations are now extracted from the wheel blocking forces. As road noise is a random phenomenon, a component analysis is performed to extract a limited number of uncorrelated excitation patterns (magnitude and phase) at the five fixed Degrees of Freedom at the wheel center. The relevance of such excitations is proved when comparing computed blocking forces at the body-suspension interface to measurements. Implicitly, this comparison also validates the numerical model (Finite Elements) of the suspension.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Second, one introduces a road noise indicator at the body-suspension interface in order to synthesize multiple degrees of freedom interactions. The indicator is based upon the power injected by the suspension in the car body. The vibroacoustic coupling with the acoustic cavity is then no longer needed to assess the suspension design. This approach has been tested experimentally on a front axle of a mid-size passenger car. Interaction forces have been computed using an inverse method while velocities were measured on the body side. Both are combined to calculate the vibratory power. This power is compared to the noise measured directly at the front and rear passengers' ears. It appears that the indicator and the averaged quadratic sound pressure are very similar. Several elastic mounts with different stiffness have been used to check the sensitivity of the indicator versus interior noise. These results suggest that even at low frequencies, rather simple energetic views of vehicle vibroacoustic problems may be of great interest.&lt;/div&gt;
On Satisfaction of the Fifth Necessary Condition of Proper Part Surface Generation in Design of Plunge Shaving Cutter for Finishing of Precision Involute Gears (2006)

In this paper, a novel modified scheme and effective computer representation for design of a plunge shaving cutter is presented. The paper aims to develop a novel design of shaving cutter for plunge shaving of precision involute gears. The study is carried out on the premise of satisfaction of the fifth necessary condition of proper part surface generation (PSG) when designing the plunge shaving cutter. In the current study, the author’s earlier developed DG/K method of surface generation is used together with the principal elements of analytical mechanics of gears. (The DG/K method is based on fundamental results obtained in differential geometry of surfaces, and on kinematics of multi-parametric motion of a rigid body in the E3 space. The interested reader may wish to go for details to the monograph: Radzevich, S.P., Fundamentals of Surface Generation, Monograph, Kiev, Rastan, 2001, 592 pp., and to: Radzevich, S.P., Sculptured Surface Machining on Multi-Axis NC Machine, Monograph, Kiev, Vishcha Schola, 1991, 192 pp.) In the particular case under consideration, the method employs (a) an analytical description of the gear tooth surface to be machined, (b) configuration of the plunge shaving cutter relative to the involute gear, (c) analytical representation of the coordinate systems transformations, and (d) the fifth condition of proper PSG that is adapted to finishing of precision involute gears. The fifth condition of proper PSG is investigated in the paper. On the premise of the obtained results of the investigation, a novel design of plunge shaving cutter for finishing of precision involute gears is proposed. The developed novel design of plunge shaving cutter can be used on shaving machines available on the market, e.g. on Gleason’s new Genesis™ 130SV computer numerical control (CNC) shaving machine.
A Partial Power Converter Interface for Battery Energy Storage Integration with a DC Microgrid (2019)

A battery energy storage system (BESS) interface for a DC microgrid, featuring a partial rated power electronic converter, is proposed in this work. Universal schemes for implementing a partial rated BESS interface are discussed and a soft-switched, dual active bridge (DAB) converter-based solution is presented. The proposed scheme is analyzed and compared with a conventional full rated BESS interface converter to showcase its benefits. A control strategy that can enable multiple operating modes for the the partial rated power electronic BESS interface is discussed. Hardware prototypes of partial rated and full rated BESS interface converter solutions that are rated to transfer 3.3 kW to the BESS are developed and tested in the laboratory. Experimental evidence suggests that the partial rated BESS interface can improve the system efficiency by up to 3% while simultaneously reducing the converter rating by about 70% as compared to that of a full rated converter. Elimination of redundant power processing by the partial rated BESS interface offers tremendous potential to improve the efficiency and power density while drastically reducing the cooling overhead.
ChemInform Abstract: Ruthenium‐Containing Phosphinesulfonate Chelate for the Hydrogenation of Aryl Ketones. (2013)

Abstract Ruthenium phosphate complexes are described as catalyst for the hydrogenation of aryl alkyl ketones.
Cyclodextrin-Based Peptide Self-Assemblies (Spds) That Enhance Peptide-Based Fluorescence Imaging and Antimicrobial Efficacy (2019)

As a result of their high specificity for their corresponding biological targets, peptides have shown significant potential in a range of diagnostic and therapeutic applications. However, their widespread use has been limited by their minimal cell permeability and stability in biological milieus. We describe here a hepta-dicyanomethylene-4<i>H</i>-pyran appended β-cyclodextrin (<b>DCM</b><sub><b>7</b></sub><b>-β-CD</b>) that acts as a delivery enhancing "host" for 1-bromonaphthalene-modified peptides, as demonstrated with peptide probes <b>P1-P4</b>. Interaction between the fluorescent peptides <b>P1-P3</b> and <b>DCM</b><sub><b>7</b></sub><b>-β-CD</b> results in the hierarchical formation of unique supramolecular architectures, which we term supramolecular-peptide-dots (<b>Spds</b>). Each <b>Spd</b> (<b>Spd-1</b>, <b>Spd-2</b>, and <b>Spd-3</b>) was found to facilitate the intracellular delivery of the constituent fluorescent probes (<b>P1-P3</b>), thus allowing spatiotemporal imaging of an apoptosis biomarker (caspase-3) and mitosis. <b>Spd-4</b>, incorporating the antimicrobial peptide <b>P4</b>, was found to provide an enhanced therapeutic benefit against both Gram-positive and Gram-negative bacteria relative to <b>P4</b> alone. In addition, a fluorescent <b>Spd-4</b> was prepared, which revealed greater bacterial cellular uptake compared to the peptide alone (<b>P4-FITC</b>) in <i>E. coli</i>. (ATCC 25922) and <i>S. aureus</i> (ATCC 25923). This latter observation supports the suggestion that the <b>Spd</b> platform reported here has the ability to facilitate the delivery of a therapeutic peptide and provides an easy-to-implement strategy for enhancing the antimicrobial efficacy of known therapeutic peptides. The present findings thus serve to highlight a new and effective supramolecular delivery approach that is potentially generalizable to overcome limitations associated with functional peptides.
Engineered Artificial Membranes (2018)

Biological membranes are ubiquitous, ranging from the cell membrane which encompasses a cell, to membranes for organelles within the cell such as the nucleus and mitochondria. This book focuses exclusively on the construction and modeling of engineered artificial membranes. We use the term “engineered membranes” to emphasize the fact that we will precisely engineer various components of the artificial membrane to achieve specific structural properties. Additionally, we model the dynamics of these engineered membranes from atoms to device. The results from artificial membranes elucidate the structural and dynamic properties of biological membranes. The interaction of biological membranes with macromolecules is key to the fight against human disease (rational drug design and construction of therapeutic protocols). As such, engineered artificial membranes in combination with accurate mathematical models provide an important tool for innovation in the pharmaceutical industry.
Design of a temporal geosocial semantic web for military stabilization and reconstruction operations (2009)

The United States and its Allied Forces have had tremendous success in combat operations. This includes combat in Germany, Japan and more recently in Iraq and Afghanistan. However not all of our stabilization and reconstruction operations (SARO) have been as successful. Recently several studies have been carried out on SARO by National Defense University as well as for the Army Science and Technology. One of the major conclusions is that we need to plan for SARO while we are planning for combat. That is, we cannot start planning for SARO after the enemy regime has fallen. In addition, the studies have shown that security, power and jobs are key ingredients for success during SARO. It is important to give positions to some of the power players from the fallen regime provided they are trustworthy. It is critical that investments are made to stimulate the local economies. The studies have also analyzed the various technologies that are needed for successfully carrying out SARO which includes sensors, robotics and information management. In this project we will focus on the information management component for SARO. As stated in the work by the Naval Postgraduate School, we need to determine the social, political and economic relationships between the local communities as well as determine who the important people are. This work has also identified the 5Ws (Who, When, What, Where and Why) and the (H).
Aripiprazole once-monthly 400 mg for long-term maintenance treatment of schizophrenia: a 52-week open-label study (2015)

The long-term safety and tolerability profile of AOM 400 was comparable to the RCTs, and the long-term therapeutic effect was maintained.