gebhart/patrepeval huggingface dataset:
Integration of a Raman spectroscopy system to a robotic-assisted surgical system for real-time tissue characterization during radical prostatectomy procedures (2019)

Surgical excision of the whole prostate through a radical prostatectomy procedure is part of the standard of care for prostate cancer. Positive surgical margins (cancer cells having spread into surrounding nonresected tissue) occur in as many as 1 in 5 cases and strongly correlate with disease recurrence and the requirement of adjuvant treatment. Margin assessment is currently only performed by pathologists hours to days following surgery and the integration of a real-time surgical readout would benefit current prostatectomy procedures. Raman spectroscopy is a promising technology to assess surgical margins: its in vivo use during radical prostatectomy could help insure the extent of resected prostate and cancerous tissue is maximized. We thus present the design and development of a dual excitation Raman spectroscopy system (680- and 785-nm excitations) integrated to the robotic da Vinci surgical platform for in vivo use. Following validation in phantoms, spectroscopic data from 20 whole human prostates immediately following radical prostatectomy are obtained using the system. With this dataset, we are able to distinguish prostate from extra prostatic tissue with an accuracy, sensitivity, and specificity of 91%, 90.5%, and 96%, respectively. Finally, the integrated Raman spectroscopy system is used to collect preliminary spectroscopic data at the surgical margin in vivo in four patients.
Amorphization of Pseudocapacitive T−Nb<sub>2</sub>O<sub>5</sub> Accelerates Lithium Diffusivity as Revealed Using Tunable Isomorphic Architectures (2022)

Abstract Intercalation pseudocapacitance can combine capacitor‐like power densities with battery‐like energy densities. Such surface‐limited behavior requires rapid diffusion where amorphization can increase solid‐state diffusivity. Here intercalation pseudocapacitive materials with tailored extents of amorphization in T‐Nb 2 O 5 are first reported. Amorphization was characterized with WAXS, XPS, XAFS, and EPR which suggested a peroxide‐rich (O 2 2− ) surface that was consistent with DFT predictions. A series of tunable isomorphic architectures enabled comparisons while independently varying transport parameters. Through process of elimination, solid‐state lithium diffusion was identified as the dominant diffusive‐constraint dictating the maximum voltage sweep rate for surface‐limited kinetics ( v SLT ), termed the Surface‐Limited Threshold (SLT). The v SLT increased with amorphization however stable cycling required crystalline T‐Nb 2 O 5 . A current‐response model using series‐impedances well‐matched these observations. This perspective revealed that amorphization of T‐Nb 2 O 5 enhanced solid‐state diffusion by 12.2 % and increased surface‐limitations by 17.0 % (stable samples). This approach enabled retaining 95 % lithiation capacity at ∼800 mV s −1 (1,600 C‐rate equivalent).
Front to back ratio improvement of the Veraphase® GNSS antenna (2016)

This paper presents two solutions to improve the front to back ratio (FBR) of the VeraPhase® (VP6000) antenna. A compact and light disk structure and a ground plane with absorber layer located under the antenna were designed and optimized in the 3D RF simulator WIPL-D in order to reduce the FBR without impacting the other performances of the antenna. The optimized results show great improvement of the FBR at all frequencies from 2.5 dB up to 7.3 dB without reducing the gain in the upper hemisphere of the antenna. The proposed solution are both efficient and low cost solutions to optimize the FBR of the VP6000.
Results Using Processed Acetylene Fuel Stream in Solid Oxide Fuel Cell Stack (2010)

Preliminary results indicate that acetylene and hydrogen peroxide are viable reactants for a solid oxide fuel cell (SOFC) system. Acetylene was hydrogenated and reformed to a suitable feed at the anode while hydrogen peroxide was decomposed to provide oxygen to the cathode. Roughly 45% fuel and oxidant utilization were demonstrated on a SOFC stack manufactured by Delphi Corporation (Troy, MI). These reactants offer high energy storage as well as an entirely self-contained power system with no exhaust streams. Such attributes are favorable for undersea vehicles and perhaps other applications that require a self-contained or air-independent power system.
The Elusive Search for “Best PEEP” and Whether Esophageal Pressure Monitoring Helps (2019)

Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA HomeNew OnlineCurrent IssueFor Authors Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) Podcasts Clinical Reviews Editors' Summary Medical News Author Interviews More JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA journal
Synthesis of 7-<sup>15</sup>N-Oroidin and Evaluation of Utility for Biosynthetic Studies of Pyrrole−Imidazole Alkaloids by Microscale <sup>1</sup>H−<sup>15</sup>N HSQC and FTMS (2010)

Numerous marine-derived pyrrole-imidazole alkaloids (PIAs), ostensibly derived from the simple precursor oroidin, 1a, have been reported and have garnered intense synthetic interest due to their complex structures and in some cases biological activity; however very little is known regarding their biosynthesis. We describe a concise synthesis of 7-(15)N-oroidin (1d) from urocanic acid and a direct method for measurement of (15)N incorporation by pulse labeling and analysis by 1D (1)H-(15)N HSQC NMR and FTMS. Using a mock pulse labeling experiment, we estimate the limit of detection (LOD) for incorporation of newly biosynthesized PIA by 1D (1)H-(15)N HSQC to be 0.96 microg equivalent of (15)N-oroidin (2.4 nmole) in a background of 1500 microg of unlabeled oroidin (about 1 part per 1600). 7-(15)N-Oroidin will find utility in biosynthetic feeding experiments with live sponges to provide direct information to clarify the pathways leading to more complex pyrrole-imidazole alkaloids.
Polypyrrole/Metal Oxides-Based Composites/Nanocomposites for Corrosion Protection (2020)

Corrosion is of paramount interest of researchers all around the world owning to its disastrous impact on economy and safety. New strategies based on novel materials have been employed to mitigate corrosion. Conducting polymer-based nanocomposites is a class of materials which has shown promise for corrosion protection. This paper will focus on the specific case of the Conducting polymer-based nanocomposites for corrosion protection and one important case will be discussed in detail. Corrosion protection offered by Polypyrrole (PPy)/Fe2O3 based composite coating for cold rolled substrate is characterized in this paper by Electrochemical Impedance Spectroscopy (EIS) and Open Circuit Potential (OCP) measurements. It was found that PPy/Fe2O3 based composite coating provides better corrosion performance after 40 days exposure to ASTM B117 salt fog test conditions. This improved performance was attributed to the increased surface area of PPy and passivating nature of composite resulting from the redox activity provided by PPy.
A technical feasibility report on correlative studies from the investigator-initiated phase II study of pembrolizumab (Pembro) immunological response evaluation (INSPIRE). (2017)

11607 Background: Validated biomarkers of response to immune checkpoint inhibitors are needed. Methods: INSPIRE (NCT02644369) is a biomarker-driven study to comprehensively evaluate changes in genomic and immune landscapes in tumors and blood of patients (pts) treated with pembro at 200 mg IV Q3W. It consists of 5 histological cohorts of 20 evaluable pts each: head and neck squamous cell cancer (SCCHN), triple negative breast cancer (TNBC), high grade serous ovarian cancer (HGSOC), melanoma (MM) and mixed solid tumors (MST). All pts undergo pre- and on-treatment (week 6-9) fresh tumor biopsies (bx), and at progression for responders. The first core bx is for immunohistochemistry and subsequent cores are pooled to create single cell suspension for 5 prioritized biomarker assay groups: (1) whole exome/RNA-/TCR-sequencing; (2) T/B/NK, APCs, and/or Treg phenotyping; (3) patient-derived xenografts; (4) RNA-seq on viably sorted immune populations; (5) TIL expansion and characterization. Serial blood samples for immunophenotyping, chemokines/cytokines and ctDNA are collected. Results: 53 pts were enrolled from March 21, 2016-January 16, 2017 (5 SCCHN, 8 TNBC, 17 HGSOC, 7 MM, 16 MST). 84 tumor bx (53 pre-, 30 on-treatment, 1 progression) and 244 blood-based biomarker samples have been collected. The most common sites of tumor bx were: lymph nodes (27%), liver (22%) and skin (14%) (see table). For the 5 cohorts, the % of tumor bx with sufficient cellularity for biomarker assay groups 1 and 2 are: SCCHN (33%), TNBC (9%), HGSOC (52%), MM (55%), MST (55%). Conclusions: This report provides robust technical feasibility data to plan immune and molecular characterization of tumor and blood-based biomarkers in pts receiving ICI. Clinical trial information: NCT02644369. [Table: see text]
Degradable Thermoset Polymer Composite for Intervention-Less Downhole Tools (2017)

Abstract Commercially available polymeric frac balls and other downhole tools made with polyglycolic acid (PGA), a thermoplastic, have severe application limitations owing to their low Tg of approximately 104°F as well as high cost. A thermoset polymer composite made from cyanate ester resin has been developed that exhibits hot-water degradability as well as excellent mechanical properties. This polymer composite demonstrates excellent potential for use in structural components of downhole tools for intervention-less operations. A degradable composite with cyanate ester resin with a glass transition temperature (Tg) of 536°F was prepared by adding inorganic fillers and glass fibers. A new process was developed to prepare a bulk molding compound from this composite that enabled fabrication of parts via compression molding. Molded parts were tested for their mechanical properties and for their degradability in water and brines. The composite with one quarter inch chopped glass fiber has a compressive strength of 41.88 ksi, tensile strength of 15.83 ksi, tensile modulus of 3.62 Msi and an elongation-at-break of 0.48%. Composite degradation occurs at 200°F and above, with a higher rate of degradation observed as the temperature increases.
Supercritical CO<sub>2</sub> Extraction as an Effective Pretreatment Step for Wax Extraction in a Miscanthus Biorefinery (2016)

The use of supercritical carbon dioxide (scCO2) to extract valuable lipophilic compounds from miscanthus was investigated and subsequent enzymatic saccharification was carried out to determine the impact of scCO2 extraction on downstream processing of miscanthus. Two miscanthus genotypes (Miscanthus x. giganteus and Miscanthus sinensis) were investigated and characterized. A diverse range of molecules were detected including long-chain hydrocarbons, fatty acids, n-policosanols, aldehydes, wax esters, sterols and steroid ketones. Quantification data indicates that there is a considerable difference among each species in the quantities of specific compounds. The waxes also exhibited significant differences in melting temperature, thus illustrating the opportunity for utilization in various applications. In addition to the isolation of valuable chemical compounds, the scCO2 pretreatment also had a beneficial effect on the downstream processing of the biomass. The total sugars released after saccharification was found to increase by around 20% when coupled with scCO2 extraction, as compared to untreated samples.
Bio‐inspired collaborative spectrum sensing and allocation for cognitive radios (2015)

Bio‐inspired techniques, including firefly algorithm, fish school search, and particle swarm optimisation, are utilised in this study to evaluate the optimal weighting vectors used in the data fusion centre. This evaluation is performed for more realistic signals that suffer from non‐linear distortions, caused by the power amplifiers. The obtained optimal weighting vectors are then used for collaborative spectrum sensing and spectrum allocation in cognitive radio networks. Numerical results show that bio‐inspired techniques outperform the conventional algorithms used for spectrum sensing and allocation by deriving optimal weights that ensure the highest value of probability of detection and guarantee the maximum proportional fair reward for users.
Evaluation of channel capacity of the OAM-based FSO links with a precise assessment of turbulence impact (2014)

The channel capacity of FSO links based on modulation of inconsecutive OAM-modes is evaluated by using modified Von Karman model. The results show significant reduces in crosstalk with channel capacity converging to an ideal case.
A coumarin-based reversible two-photon fluorescence probe for imaging glutathione near <i>N</i>-methyl-<scp>d</scp>-aspartate (NMDA) receptors (2022)

Glutathione (GSH) is known to play a key role in the modulation of the redox environment in <i>N</i>-methyl-d-aspartate (NMDA) receptors. Coumarin derivative 1 bearing cyanoacrylamide and ifenprodil moieties was synthesized and reported to monitor GSH near NMDA receptors. The cyanoacrylamide moiety allows probe 1 to monitor GSH reversibly at pH 7.4 and the ifenprodil group acts as a directing group for NMDA receptors. Two-photon fluorescence microscopy allows probe 1 to successfully sense endogenous GSH in neuronal cells and hippocampal tissues with excitation at 750 nm. Furthermore, the addition of H<sub>2</sub>O<sub>2</sub> and GSH induced a decrease and an increase in fluorescence emission. Probe 1 can serve as a potential practical imaging tool to get important information on GSH in the brain.
Interictal EEG, Hippocampal Atrophy, and Cell Densities in Hippocampal Sclerosis and Hippocampal Sclerosis Associated With Microscopic Cortical Dysplasia (2002)

The EEG characteristics of isolated hippocampal sclerosis (HS) and HS associated with other types of temporal lobe pathology are not well defined. The pathologic substrate may be an important variable in determining seizure-free outcome. The objective of this study was to define the distribution of epileptiform discharges in patients with HS and HS associated with microscopic dysplasia, and to examine their relationship with hippocampal atrophy and cell loss. Thirty-four patients (15 women and 19 men; mean age, 30.6 +/- 11.2 years), all with good outcomes after temporal lobectomy (Engel classes I and II), were included. The characteristics studied were frequency and distribution of spikes, MRI-based hippocampal volume ratios, and quantitative hippocampal cell density in various subregions. The isolated HS group showed a trend to a higher percentage of epileptiform discharges maximal at the anterior temporal electrodes (89.87 +/- 17.0%; 79.5 +/- 28.2% in the dual-pathology group). The isolated HS group had, on average, significantly more cell loss (P < 0.001). There was a significant negative correlation between the amount of cell loss in the CA1 area and both anterior temporal spikes and hippocampal ratios (P < 0.05). Isolated HS and dual pathology show minimal differences in interictal spike distribution and frequency. More widespread spike distributions in severe isolated HS compared with patients with less cell loss is probably the result of less organized limbic circuitry.
Intramembrane Interactions between Neurotensin Receptors and Dopamine D<sub>2</sub> Receptors as a Major Mechanism for the Neuroleptic‐like Action of Neurotensina (1992)

Evidence has been presented that behavioral actions of NT, inducing its neuroleptic-like action, can be explained on the basis of NT-D2 intramembrane receptor-receptor interactions in the basal ganglia, unrelated to the coexistence phenomenon, leading to reduced affinity and transduction of the D2 agonist binding site. By reducing selectively D2 receptor transduction at the pre- and postsynaptic level, the NT receptor appears capable of switching the DA synapses towards a D1 receptor-mediated transduction, illustrating how receptor-receptor interactions can increase the functional plasticity of central synapses (FIG. 12).
Molybdenum cofactor deficiency: Identification of a patient with homozygote mutation in the <i>MOCS3</i> gene (2017)

We describe the clinical presentation and 17 years follow up of a boy, born to consanguineous parents and presenting with intellectual disability (ID), autism, "marfanoid" dysmorphic features, and moderate abnormalities of sulfite metabolism compatible with molybdenum cofactor deficiency, but normal sulfite oxidase activity in cultured skin fibroblasts. Genomic exome analysis revealed a homozygous MOCS3 missense mutation, leading to a p.Ala257Thr substitution in the highly conserved ubiquitin-like-domain of the protein. MOCS3 is the third protein, besides MOCS1 and MOCS2, involved in the biosynthesis of the molybdenum cofactor and has a dual ubiquitin-like function in tRNA thiolation. It is plausible that the phenotype results from deficiency of this dual function, not only from defective synthesis of molybdenum cofactor, which would explain similarities and differences from the MOCS1 and MOCS2-related disorders. This observation should encourage testing of additional ID patients with mild abnormalities of sulfite metabolism for MOCS3 mutations.
Monolithic Integrated OLED–OPD Unit for Point-of-Need Nitrite Sensing (2022)

In this study, we present a highly integrated design of organic optoelectronic devices for Point-of-Need (PON) nitrite (NO2-) measurement. The spectrophotometric investigation of nitrite concentration was performed utilizing the popular Griess reagent and a reflection-based photometric unit with an organic light emitting diode (OLED) and an organic photodetector (OPD). In this approach a nitrite concentration dependent amount of azo dye is formed, which absorbs light around ~540 nm. The organic devices are designed for sensitive detection of absorption changes caused by the presence of this azo dye without the need of a spectrometer. Using a green emitting TCTA:Ir(mppy)<sub>3</sub> OLED (peaking at ~512 nm) and a DMQA:DCV3T OPD with a maximum sensitivity around 530 nm, we successfully demonstrated the operation of the OLED-OPD pair for nitrite sensing with a low limit of detection 46 µg/L (1.0 µM) and a linearity of 99%. The hybrid integration of an OLED and an OPD with 0.5 mm × 0.5 mm device sizes and a gap of 0.9 mm is a first step towards a highly compact, low cost and highly commercially viable PON analytic platform. To our knowledge, this is the first demonstration of a fully organic-semiconductor-based monolithic integrated platform for real-time PON photometric nitrite analysis.
Prognostic value of Dicer expression in human breast cancers and association with the mesenchymal phenotype (2009)

Assessment of Dicer expression may facilitate prediction of distant metastases for patients suffering from breast cancer.
Proceedings of the 2nd International Workshop on Multimedia Forensics and Security (2017)

It is our great pleasure to welcome you to the Second International Workshop on Multimedia Forensics and Security -- MFSec 2017, organized in conjunction with the 2017 ACM Conference on Multimedia Retrieval -- ICMR2017, held in Bucharest, Romania. The goal of MFSec 2017 is three-fold: First, the workshop aims at presenting cutting-edge forensic and security methods aimed at Web and social media applications. Second, it aspires to bring together key individuals from the research and professional communities, from the fields of security, forensics, and multimedia analysis and retrieval, to exchange ideas and experiences and shape the directions of the field for the future. Third, the workshop intends to evaluate the level maturity of the field, identify the current strengths and weaknesses, and encourage progress towards novel solutions. This year's focus was placed on Web and social media environments, and the particular challenges that these environments pose to the field. The Workshop received 9 submissions, of which 5 were accepted by the Program Committee, leading to a 56% acceptance rate. Accepted submissions cover a wide range of challenges, from multimedia forensics using content and context, to the tracking of terrorism- and weaponrelated sources in the Web.
S1601-1-2 Development of a solid polymer electrolyte sensor (2009)

This paper describes a development of a polymer sensor using solid polymer electrolyte (SPE) film. The sensor has a basic structure that a SPE film is sandwiched between thin carbon films and conductive tape is attached on each carbon film. SPE film has a good flexibility, and can be used in air. First, output response to deformation is confirmed by applying the displacement to the sensor. Then a curvature sensor using the material is proposed. In experiments, it is found that the proposed sensor is available to measure the curvature directly.