gebhart/patrepeval huggingface dataset:
A model‐based dead‐band compensation for the dual‐active‐bridge isolated bidirectional DC–DC converter (2011)

Abstract The dual active bridge (DAB)‐based isolated bidirectional converter has been used to realize bidirectional energy flow while offering needed isolation between the primary and secondary side: for example, the battery side and grid side of one plug‐in hybrid electric vehicle (PHEV). Even though the operation of a DAB‐based DC–DC converter is straightforward, various transient processes exist, such as the dead‐band effect, which deeply affects the dynamic performance of the converter in real world applications. Compensation of this effect is not easy because of the strong nonlinearity of the entire system. This paper quantitatively analyzed the dead‐band effect at different output powers, and presented a model‐based controller to realize the nonlinear dead‐band compensation strategy, which can effectively mitigate demerits of the traditional PI‐based control strategy. The proposed control algorithm is validated through theoretical simulation and experimental results. © 2011 Institute of Electrical Engineers of Japan. Published by John Wiley &amp; Sons, Inc.
Development of an Integrated Reporting System for Verifying Hemolysis, Icterus, and Lipemia in Clinical Chemistry Results (2014)

The HIL alert index values for chemical analytes varied depending on the chemistry analyzer. This integrated HIL reporting system provides an effective screening tool for verifying specimen quality with regard to HIL and simplifies the laboratory workflow.
Genomic landscape of retinoblastoma in <i>Rb<sup>−/−</sup>p130<sup>−/−</sup></i> mice resembles human retinoblastoma (2016)

Several murine retinoblastoma models have been generated by deleting the genes encoding for retinoblastoma susceptibility protein pRb and one of its family members p107 or p130. In Rb<sup>-/-</sup> p107<sup>-/-</sup> retinoblastomas, somatic copy number alterations (SCNAs) like Mdm2 amplification or Cdkn2a deletion targeting the p53-pathway occur, which is uncommon for human retinoblastoma. In our study, we determined SCNAs in retinoblastomas developing in Rb<sup>-/-</sup> p130<sup>-/-</sup> mice and compared this to murine Rb<sup>-/-</sup> p107<sup>-/-</sup> tumors and human tumors. Chimeric mice were made by injection of 129/Ola-derived Rb<sup>-/-</sup> p130<sup>-/-</sup> embryonic stem cells into wild type C57BL/6 blastocysts. SCNAs of retinoblastoma samples were determined by low-coverage (∼0.5×) whole genome sequencing. In Rb<sup>-/-</sup> p130<sup>-/-</sup> tumors, SCNAs included gain of chromosomes 1 (3/23 tumors), 8 (1/23 tumors), 10 (1/23 tumors), 11 (2/23 tumors), and 12 (4/23 tumors), which could be mapped to frequently altered chromosomes in human retinoblastomas. While the altered chromosomes in Rb<sup>-/-</sup> p130<sup>-/-</sup> tumors were similar to those in Rb<sup>-/-</sup> p107<sup>-/-</sup> tumors, the alteration frequencies were much lower in Rb<sup>-/-</sup> p130<sup>-/-</sup> tumors. Most of the Rb<sup>-/-</sup> p130<sup>-/-</sup> tumors (16/23 tumors, 70%) were devoid of SCNAs, in strong contrast to Rb<sup>-/-</sup> p107<sup>-/-</sup> tumors, which were never (0/15 tumors) SCNA-devoid. Similarly, to human retinoblastoma, increased age at diagnosis significantly correlated with increased SCNA frequencies. Additionally, focal loss of Cdh11 was observed in one Rb<sup>-/-</sup> p130<sup>-/-</sup> tumor, which enforces studies in human retinoblastoma that identified CDH11 as a retinoblastoma suppressor. Moreover, based on a comparison of genes altered in human and murine retinoblastoma, we suggest exploring the role of HMGA1 and SRSF3 in retinoblastoma development. © 2016 Wiley Periodicals, Inc.
Consequences of ultrafiltration and ultraviolet on the quality of white birch (Betula platyphylla var. japonica) sap during storage (2013)

This study was conducted to evaluate the effect combined with ultrafiltration (UF) and ultraviolet (UV) pasteurization on the quality of white birch (Betula platyphylla var.japonica) sap during 40thday of storage at 4 and 25 degrees C. Some samples were treated with UF (a pore size not more than 0.03 m)or UV independently and the other sample was treated with a combination of UF and UV devices. Total microbial number of control samples was 104 CFU/ml. After treatment, they were 102 CFU/ml in UF, 103 CFU/ml in UV, and not detected in the mutually treatment of UF and UV devices. After treatment with a combination of UF and UV devices, the pH, total acidity, browning index, turbidity, and total microbial number were very stable until 40thday of storage at both 4 and 25 degrees C. Also in the UF, UV treatment independently, total acidity, browning index, turbidity, and total microbial number were increased lower than control, while the pH decreased during storage periods. Especially, in the UF, UV treatment independently, microbial number increased continuously, but in the combined consequences of UF and UV, those were not detected at all during 40th day of storage. Hence, combined consequences of UF and UV were considered as the effective method to improve the shelf-life of white birch sap.
HIV testing and counselling for women attending child health clinics: an opportunity for entry to prevent mother-to-child transmission and HIV treatment (2008)

This study assessed the potential for HIV testing at child health clinics to increase knowledge of HIV status, and entry to infant feeding counselling and HIV treatment. At a provincial hospital in Mombasa, Kenya, HIV testing and counselling were offered to women bringing their child for immunization or acute care services. Most women said HIV testing should be offered in these clinics (472/493, 95.7%), with many citing the benefits of regular testing and entry to prevent mother-to-child transmission. Of 500 women, 416 (83.4%) received test results, 97.6% on the same day. After 50 participants, point-of-care testing replaced laboratory-based rapid testing. Uptake increased 2.6 times with point-of-care testing (95% confidence interval = 1.4-5.1; P = 0.003). Of 124 women who had not accessed HIV testing during pregnancy, 98 tested in the study (79.0%). Measured by uptake and attitudes, HIV testing in child health clinics is acceptable. This could optimize entry into HIV treatment, infant feeding counselling and family planning services.
Supplementary Table 1 from SOX9 Defines Distinct Populations of Cells in SHH Medulloblastoma but Is Not Required for Math1-Driven Tumor Formation (2023)

&lt;p&gt;Sox9 immunostaining pattern in a variety of Shh-MB genetic mouse models&lt;/p&gt;
Emerging chemistry technologies for a better world (2022)

Chemistry plays a key role in tackling today’s challenges and ensuring a sustainable future. Since 2019, IUPAC has been identifying technologies with the potential to advance our society and improve our quality of life.
Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor (2012)

Latent herpes simplex virus-1 (HSV1) genomes in peripheral nerve ganglia periodically reactivate, initiating a gene expression program required for productive replication. Whether molecular cues detected by axons can be relayed to cell bodies and harnessed to regulate latent genome expression in neuronal nuclei is unknown. Using a neuron culture model, we found that inhibiting mTOR, depleting its regulatory subunit raptor, or inducing hypoxia all trigger reactivation. While persistent mTORC1 activation suppressed reactivation, a mutant 4E-BP (eIF4E-binding protein) translational repressor unresponsive to mTORC1 stimulated reactivation. Finally, inhibiting mTOR in axons induced reactivation. Thus, local changes in axonal mTOR signaling that control translation regulate latent HSV1 genomes in a spatially segregated compartment.
Acoustic characterisation of double-orifice configurations by means of a LES-SI approach (2015)

A numerical study of the aeroacoustic properties of a pair of orifices placed in a duct is here presented. Two geometric configurations with two different distances in between the orifices have been analysed to consider conditions with or without tonal noise sources. A Large Eddy Simulation has been performed and validated with respect to experimental measurements for both aerodynamic and acoustic predictions. Data series from an acoustically excited LES have been post-processed through System Identification techniques to concurrently model noise sources and acoustic scattering matrix. The model of the noise obtained has been used as validation to confirm the good prediction of the acoustic scattering.
Miniaturized FTIR-spectrometer based on optical MEMS translatory actuator (2007)

In this paper we present a MOEMS based miniaturized Fourier-transform infrared (FTIR) spectrometer capable to perform time resolved measurements from NIR to MIR. The FTIR-spectrometer is based on a MOEMS translatory actuator which replaces the macroscopic mirror drive enabling a miniaturized, robust and low cost FTIR system. The MOEMS device is manufactured in a CMOS compatible process using SOI technology. Due to the electrostatic driving principle based on in-plane electrode combs, 200 μm stroke can be achieved with comparatively low voltages (<40 V) at an ambient pressure below 500 Pa. The actuator plate, acting as mirror with an area of 1.65 mm<sup>2</sup>, operates at a resonant frequency of 5 kHz. Consequently this yields a maximum spectral resolution of 25 cm<sup>-1</sup> and an acquisition time of 200 μs per spectrum. Based on a Michelson setup the infrared optical bench of the presented FTIR system is designed to account for the mirror aperture and the desired spectral bandwidth of 2 μm to 5 μm. The integrated signal processing electronics has to cope with a bandwidth of 8 MHz as a result of the mirror motion. A digital signal processor manages system control and data processing. The high acquisition rate and integration level of the system makes it appropriate for applications like process control and surveillance of fast reactions. First results of transmission and absorbance measurements are shown. In addition we present a novel MOEMS device with increased mirror aperture and stroke which will be used for further optimization of the spectral FTIR-resolution.
A novel dioxygenation product of arachidonic acid possesses potent chemotactic activity for human polymorphonuclear leukocytes. (1983)

We have found that a novel dioxygenation product of arachidonic acid, 8(S),15(S)-dihydroxy-5,11-cis-9,13-trans-eicosatetraenoic acid (8,15-diHETE), possesses chemotactic activity for human polymorphonuclear leukocytes comparable to that of leukotriene B4. Authentic 8,15-diHETE, identified by gas chromatography-mass spectrometry, was prepared by treating arachidonic acid with soybean lipoxygenase and was purified by reverse-phase high performance liquid chromatography. Using a "leading front" assay, 8,15-diHETE exhibited significant chemotactic activity at a concentration of 5.0 ng/ml. Maximum chemotactic activity was observed at a concentration of 30 ng/ml. The 8,15-diHETE generated by mixed human leukocytes after stimulation with arachidonic acid and the calcium ionophore, A23187, exhibited quantitatively similar chemotactic activity. Two synthetic all-trans conjugated isomers of 8,15-diHETE, however, were not chemotactic at concentrations up to 500 ng/ml. In contrast to its potent chemotactic activity, 8,15-diHETE (at concentrations up to 10 micrograms/ml) was relatively inactive with respect to its ability to provoke either degranulation or generation of superoxide anion radicals by cytochalasin B-treated leukocytes. Both leukotriene B4 and 8,15-diHETE may be important mediators of inflammation.
The Inherent Processivity of the Human de Novo Methyltransferase 3A (DNMT3A) Is Enhanced by DNMT3L (2010)

Human DNMT3A is responsible for de novo DNA cytosine methylation patterning during development. Here we show that DNMT3A methylates 5-8 CpG sites on human promoters before 50% of the initially bound enzyme dissociates from the DNA. Processive methylation is enhanced 3-fold in the presence of DNMT3L, an inactive homolog of DNMT3A, therefore providing a mechanism for the previously described DNMT3L activation of DNMT3A. DNMT3A processivity on human promoters is also regulated by DNA topology, where a 2-fold decrease in processivity was observed on supercoiled DNA in comparison with linear DNA. These results are the first observation that DNMT3A utilizes this mechanism of increasing catalytic efficiency. Processive de novo DNA methylation provides a mechanism that ensures that multiple CpG sites undergo methylation for transcriptional regulation and silencing of newly integrated viral DNA.
Squeezable tunnel junctions (1985)

Squeezable tunnel junctions set the current state of the art for resistance stability of mechanically adjustable tunneling structures at Delta R/R approx 0.1%. This is sufficient for spectroscopies as subtle as phonon spectroscopy, but it is marginal and cannot be maintained to high enough bias voltage to permit molecular vibrational spectroscopy at present. Squeezable junctions have been used for characterizing bulk samples and for C-V analysis on semiconductors. Keywords include: Tunneling, microscope, IBM Zurich squeezable tunnel junctions, Rigidity, Thermal drift, Atoms, and Liquid nitrogen.
Implementing MicaZ Support for the AVRora Simulator (2005)

2005 CENS Undergraduate InternAvrora, a set of simulation and analysis tools created by the UCLA compilers group, is designed to allow for the debugging of programs meant to run on sensor-networks, as well as provide tools to aid in the analysis of how those programs affect the sensor nodes both individually as well as in a sensor network. The goal of the summer is to implement support for other platform types and thus increase AvroraâÂ¡Ãs ability to simulate other types of sensor networks. This objective requires research of different platforms which may share similar devices to those of the already implemented MicaZ and Tmote Sky. In the future, this can lead to the ability to simulate different varieties of sensor netowkrs including heterogeneous networks.
The Interaction of Protein S with the Phospholipid Surface Is Essential for the Activated Protein C-independent Activity of Protein S (1996)

Protein S is a vitamin-K dependent glycoprotein involved in the regulation of the anticoagulant activity of activated protein C (APC). Recent data showed a direct anticoagulant role of protein S independent of APC, as demonstrated by the inhibition of prothrombinase and tenase activity both in plasma and in purified systems. This anticoagulant effect of protein S can be explained either by a direct interaction of protein S with one of the components of the complexes and/or by the interference with the binding of these components to phospholipid surfaces. During our investigation we noted that protein S preparations purified in different ways and derived from different sources, expressed discrepant APC cofactor and direct anticoagulant activity. In order to elucidate these differences and to study the mechanism of the APC-independent activity of protein S, we compared the protein S preparations in phospholipid-binding properties and anticoagulant activity. The dissociation constant for the binding of protein S to immobilized phospholipids ranged from 7 to 74 nM for the different protein S preparations. APC-independent inhibition of both prothrombinase and tenase activity performed on phospholipid vesicles and in plasma showed a strong correlation with the affinity for phospholipids. The APC-independent activity could be abolished by monoclonal antibodies that were either calcium-dependent and/or directed against epitopes in the Gla-region of protein S, suggesting that the protein S-phospholipid interaction is crucial for the APC-independent anticoagulant function of protein S. Protein S preparations with a low APC-independent activity expressed a high APC-cofactor activity suggesting that the affinity of protein S for phospholipids is of less importance in the expression of APC-cofactor activity of protein S. We conclude that high affinity interactions of protein S with the membrane surface are essential for the direct anticoagulant activity of protein S and we suggest that inhibition of the prothrombinase and the tenase complex by protein S is a consequence of the occupation of the phospholipid surface by protein S molecules.
Faculty Opinions recommendation of Microscopy ambient ionization top-down mass spectrometry reveals developmental patterning. (2013)

There is immense cellular and molecular heterogeneity in biological systems. Here, we demonstrate the utility of integrating an inverted light microscope with an ambient ionization source, nanospray electrospray desorption ionization, attached to a high-resolution mass spectrometer to characterize the molecular composition of mouse spinal cords. We detected a broad range of molecules, including peptides and proteins, as well as metabolites such as lipids, sugars, and other small molecules, including S-adenosyl methionine and glutathione, through top-down MS. Top-down analysis revealed variation in the expression of Hb, including the transition from fetal to adult Hb and heterogeneity in Hb subunits consistent with the genetic diversity of the mouse models. Similarly, temporal changes to actin-sequestering proteins β-thymosins during development were observed. These results demonstrate that interfacing microscopy with ambient ionization provides the means to perform targeted in situ ambient top-down mass spectral analysis to study the pattern of proteins, lipids, and sugars in biologically heterogeneous samples. PMID: 23969833 Funding information This work was supported by: NINDS NIH HHS, United States Grant ID: R37 NS037116 NIGMS NIH HHS, United States Grant ID: GM094802 NINDS NIH HHS, United States Grant ID: R37NS037116 Howard Hughes Medical Institute, United States NIGMS NIH HHS, United States Grant ID: R01 GM094802
Interception of Quorum Sensing in Staphylococcus aureus: A New Niche for Peptidomimetics (2006)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Vulnerabilities and Security Threats in Structured Overlay Networks: A Quantitative Analysis (2005)

A number of recent applications have been built on distributed hash tables (DHTs) based overlay networks. Almost all DHT-based schemes employ a tight deterministic data placement and ID mapping schemes. This feature on one hand provides assurance on location of data if it exists, within a bounded number of hops, and on the other hand, opens doors for malicious nodes to lodge attacks that can potentially thwart the functionality of the overlay network. This paper studies several serious security threats in DHT-based systems through two targeted attacks at the overlay network's protocol layer. The first attack explores the routing anomalies that can be caused by malicious nodes returning incorrect lookup routes. The second attack targets the ID mapping scheme. We disclose that the malicious nodes can target any specific data item in the system; and corrupt/modify the data item to its favor. For each of these attacks, we provide quantitative analysis to estimate the extent of damage that can be caused by the attack; followed by experimental validation and defenses to guard the overlay networks from such attacks.
Characterization of gain- and index-guided InGaN multiple quantum well laser diodes (2002)

We will discuss fabrication and characteristics of III-nitride based multiquantum well (MQW) laser diodes grown on c-plane sapphire substrates by metal organic chemical vapor deposition (MOCVD). The device structure includes a 4 /spl mu/m GaN:Si lateral n-contact layer, 0.4 /spl mu/m AlGaN cladding layers, and a InGaN multiple quantum well active region surrounded by 0.1 /spl mu/m GaN:Si waveguide layers.
Materials solidification physics in space (2008)

The article presents a short overview on the basics solidification physics behind future experiments within the Materials Science Lab (MSL) of the International Space Station, ISS, and experimental results achieved so far in the ground based research studies as well as sounding rockets. The short paper highlights the importance of solidification research to be performed in space.&#13;\n
Clustering Approach Based On Von Neumann Topology Artificial Bee Colony Algorithm (2011)

Article Bee Colony (ABC) is one of the most recently introduced algorithms based on the intelligent foraging behavior of a honey bee swarm. This paper proposes a new variant of the ABC algorithm based on Von Neumann topology structure, namely Von Neumann Neighborhood Article Bee Colony (VABC). VABC significantly improves the original ABC in solving complex optimization problems. Clustering is a popular data analysis and data mining technique. The most popular technique for clustering is k-means algorithm. However, the k-means algorithm highly depends on the initial state and converges to local optimum olution. In this work, VABC algorithm is tested on a set of widely-used benchmark functions and is used for solve data clustering on several benchmark data sets. The performance of VABC algorithm is compared with ABC and Particle Swarm Optimization (PSO) algorithms. The simulation results show that the proposed VABC outperforms the other two algorithms in terms of accuracy, robustness, and convergence speed.
Improving power allocation to MIMO eigenbeams under imperfect channel estimation (2005)

Eigenbeamforming exploits the spatial diversity of the MIMO channel by multiplexing data substreams along orthogonal modes. Estimation errors result in self-interference, which must be taken into account in the selection of modes for transmission and the allocation of transmitter power. Using perturbation analysis to evaluate the self-interference, a technique is proposed for determining the power allocation which achieves a specified performance, based only on the information available at the receiver.
Molecular Nanomagnets (2010)

This chapter contains sections titled: Introduction A Very Brief Introduction to Magnetochemistry Techniques Single Molecule Magnets Emerging Trends References
Reactive infinite order sudden rate constants for atomic fluorine + molecular hydrogen(v = 0, j = 0) .fwdarw. atomic hydrogen + hydrogen fluoride(v') (1983)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReactive infinite order sudden rate constants for atomic fluorine + molecular hydrogen(v = 0, j = 0) .fwdarw. atomic hydrogen + hydrogen fluoride(v')J. Jellinek, M. Baer, and D. J. KouriCite this: J. Phys. Chem. 1983, 87, 18, 3370–3372Publication Date (Print):September 1, 1983Publication History Published online1 May 2002Published inissue 1 September 1983https://pubs.acs.org/doi/10.1021/j100241a004https://doi.org/10.1021/j100241a004research-articleACS PublicationsRequest reuse permissionsArticle Views24Altmetric-Citations5LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts