gebhart/patrepeval huggingface dataset:
Synthesis and physicochemical, DFT, thermal and DNA-binding analysis of a new pentadentate N<sub>3</sub>S<sub>2</sub> Schiff base ligand and its [CuN<sub>3</sub>S<sub>2</sub>]<sup>2+</sup> complexes (2020)

A new N<sub>3</sub>S<sub>2</sub> pentadentate Schiff base ligand derived from 5-bromothiophene-2-carbaldehyde, (<i>E</i>)-<i>N</i>1-((5-bromothiophen-2-yl)methylene)-<i>N</i>2-(2-((<i>E</i>)-((5-bromothiophen-2-yl)-methylene amino) ethyl ethane-1,2-diamine, is prepared. The ligand and its complexes are subjected to extensive physical and theoretical analyses and the results are consistent with their predicted compositions. Dicationic Cu(ii) complexes ([CuN<sub>3</sub>S<sub>2</sub>]X<sub>2</sub>) with a coordination number of 5 are proposed on the basis of the spectral data with N<sub>3</sub>S<sub>2</sub> serving as a pentadentate ligand. The prepared complexes display a square pyramidal geometry around the Cu(ii) center. TG shows different thermal behavior for the N<sub>3</sub>S<sub>2</sub> ligand and its complexes. Solvatochromism of the complexes is promoted by the polarity of the solvent used. A one-electron transfer Cu(ii)/Cu(i) reversible redox reaction is promoted by CV. SEM and EDS of the free ligand and its complexes support the morphology and composition changes observed upon the complexation of Cu(ii). As an outstanding goal to develop anticancer new metal chemotherapy, preliminary studies of the binding of the desired complexes with DNA were carried out, as it is through judging the strength of interactions that a future drug can be designed and synthesized. The viscosity and absorption results obtained for complex 1 indicated its enhanced CT-DNA binding properties as compared to those of complex 2 with <i>K</i> <sub>b</sub> values of 3.2 × 10<sup>5</sup> and 2.5 × 10<sup>5</sup> M<sup>-1</sup>, respectively.
Supplementary Figure 7 from Raf Kinase Inhibitor RKIP Inhibits MDA-9/Syntenin-Mediated Metastasis in Melanoma (2023)

&lt;p&gt;PDF file - 171K, Effect of ectopic expression of RKIP on cytoskeletal organization in melanoma cells&lt;/p&gt;
Devoid Clutter Capture and Filling (DeCCaF) to Compensate for Intra-CPI Spectral Notch Variation (2019)

Cognitive spectral notching of FM noise waveforms on transmit has been experimentally shown to be an effective means with which to avoid in-band interference. However, to contend with dynamic interference the transmit notch may be required to move during the coherent processing interval (CPI), which introduces a nonstationarity effect that results in increased residual clutter after cancellation. It was recently shown that optimal mismatched filtering (MMF) can partially mitigate this degradation while maintaining the necessary spectral notch for interference mitigation.Here a new approach to compensate for this nonstationarity is proposed that borrows the missing portion of the clutter (due to notching) from another pulsed response for which the notch is in a different location. By using this borrowed response to fill in the notched clutter, subsequent clutter cancellation largely avoids the nonstationarity effect so that the corresponding residue is reduced. It is shown using measured data that the combination of this clutter filling approach with notched MMFs realizes clutter cancellation performance on par with full-band random waveforms that do not possess spectral notching.
Fiber-mirror integrated compliant mechanical system for measuring force and displacement simultaneously (2015)

Measuring force and displacement in some environments is not a straight forward task. For example, in the presence of flammable materials or when surgery robots are dealing with human body, force and displacement sensors should be redesigned for this use. In surgical applications, the sensors have to be electrically passive and EMI compatible. Many kinds of sensors have been introduced for this application, namely, peizoresistive, strain gauges, etc. Although these sensors have many advantages in this regard, they are neither compatible with EMI environments nor electrically passive. So, a novel method of optical sensing need to be developed for these applications. The optical sensors may be fabricated in micro scales to overcome aforementioned needs. Some examples of optical force sensors work based on light transmission in optical fibers [1]. The proposed optical sensor is quite simple and it measures both force and displacement using only one moving object. In the proposed system, light from an optical fiber is reflected by an integrated mirror fabricated through micromachining. The light that gets coupled back into the fiber is dependent on the gap and angular misalignment between the fiber and mirror that varies with applied force and displacement. Finite element modeling of the sensor was carried out with COMSOL and optical loss was estimated for different applied forces. This paper presents the design, modeling and performance behavior of the proposed system in terms of optical loss for different applied loads.
Comprehensive and Practical Vision System for Self-Driving Vehicle Lane-Level Localization (2016)

Vehicle lane-level localization is a fundamental technology in autonomous driving. To achieve accurate and consistent performance, a common approach is to use the LIDAR technology. However, it is expensive and computational demanding, and thus not a practical solution in many situations. This paper proposes a stereovision system, which is of low cost, yet also able to achieve high accuracy and consistency. It integrates a new lane line detection algorithm with other lane marking detectors to effectively identify the correct lane line markings. It also fits multiple road models to improve accuracy. An effective stereo 3D reconstruction method is proposed to estimate vehicle localization. The estimation consistency is further guaranteed by a new particle filter framework, which takes vehicle dynamics into account. Experiment results based on image sequences taken under different visual conditions showed that the proposed system can identify the lane line markings with 98.6% accuracy. The maximum estimation error of the vehicle distance to lane lines is 16 cm in daytime and 26 cm at night, and the maximum estimation error of its moving direction with respect to the road tangent is 0.06 rad in daytime and 0.12 rad at night. Due to its high accuracy and consistency, the proposed system can be implemented in autonomous driving vehicles as a practical solution to vehicle lane-level localization.
A 0.8V 875 MS/s 7b low-power SAR ADC for ADC-Based Wireline Receivers in 22nm FDSOI (2020)

International audience
Crystallinity and mesoporosity of carbon produced from ligno-<i>p</i>-cresol and their improvement by pulverization and acid treatment (2007)

Abstract Crystallized mesoporous carbon was produced from ligno- p -cresol, a lignin derivative obtained by phase separation with p -cresol and sulfuric acid, onto which 3% nickel and 2% calcium were co-loaded, by carbonization at 900°C. Subsequent pulverization followed by soaking in acid improved the crystallinity of carbon with an increased volume of mesopore, attaining approximately 90% and 99% removal of nickel and calcium, respectively. These aspects implied both enhancement of electroconductivity and liquid phase adsorption capacity of the carbon with a good outlook on the recovery and reuse of the two metals. In particular, combination of wet milling using small beads and mild soaking with diluted acid was appropriate in respect of relevant properties of the carbon, including the particle size. It can thus be concluded that incorporation of such post-treatments into the manufacturing process of carbon products is greatly advantageous.
Transforming Region of 243 R E1A Contains Two Overlapping but Distinct Transactivation Domains (1997)

Conserved regions 1 and 2 as well as the amino terminus of E1A are required for the transforming activity of the E1A oncoprotein. We show here that the amino terminus of 243R E1A has transactivation activity when brought to a promoter in yeast. Recruitment to a specific promoter is essential. Mutagenesis studies correlated the transactivation function with the extreme amino terminus and the conserved region 1 of E1A. Cotransfection assays in rodent cells confirmed that two overlapping but distinguishable domains, amino acids 1-65 and 37-80, can transactivate independently when targeted to a promoter. We also observed that when recruited to the proliferating cell nuclear antigen (PCNA) promoter, the amino-terminal region was sufficient to transactivate the PCNA promoter. On the other hand, deletion of the amino terminus of E1A resulted in failure to induce PCNA expression. Fusion of VP16 with the amino-terminal-deleted E1A mutant was able to restore the ability to induce the PCNA promoter. We further show that the amino-terminal region also is required for 243R E1A to repress the transactivation mediated by a universal transactivator DBD.VP16 and DBD.E1A. This repression could be specifically relieved by overexpression of TBP but not TFIIB. In addition, we show that the amino terminus of E1A is involved in in vitro interaction with the TATA binding protein (TBP). Thus the amino-terminal transforming region of E1A may regulate cellular gene expression in species that are distant in evolution via a common mechanism, functionally targeting TBP.
Effect of Anode Side Purge Gas on the Degradation of Solid Oxide Electrolysis Cells (2021)

Solid oxide electrolysis cells (SOECs) has drawn great interest in recent years due to its high power to fuel efficiency. The technology is believed to be able to play an important role in the power-to-x (P2X) and carbon capture and utilization (CCU) applications due to its capability of CO 2 electrolysis and H 2 O + CO 2 co-electrolysis. The syngas produced from SOEC can be further catalytic converted into different higher value synthetic fuels, which is essential for the green transition of those hard-to-be-electrified sectors such as aviation and heavy transportation. Large-scale implementation of such a technology requires SOEC to be cost competitive with the current existing electrolysis technologies. High performance and long-term durability are keys to further bring down the SOEC fuel production costs. Understanding the degradation mechanisms and identifying limits for a “safe-operation-window” for which the degree of degradation is limited will help to further advance the SOEC technology to the market. In this work, the influence of operation parameters such as temperature, gas composition and reactant utilization on the SOECs’ degradation were examined with commercial solid oxide cells from Elcogen. The degradation mechanisms investigated by electrochemical impedance and post-test microstructure analysis will be presented and discussed. This work has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 838014 (C2FUEL).
Birefringence control and dimension monitoring of silica-based ridge waveguides using Bragg gratings and ultraviolet irradiation (2005)

A simple numerical method is developed to analyze how the intrinsic birefringence of silica-based ridge waveguides changes with waveguide dimensions and UV irradiation. Identical Bragg gratings were induced on waveguides with different widths which varied from 5 µm×6 µm to 9 µm×6 µm with ArF excimer irradiation and a phase mask. The variation of the waveguide effective index and birefringence as a function of the waveguide dimensions and UV processing are observed and quantified by monitoring the shifts in Bragg wavelength with UV irradiation. With UV irradiation, zero birefringence was easily realized in the waveguides, having an initial birefringence of <2.5×10–4. The mechanism for controlling the waveguide birefringence with UV irradiation is verified both in the theoretical analysis and experimentally. Additionally, the ±0.1-nm variation in Bragg wavelength for waveguides with the same nominal width corresponds to a ±0.1-µm dimensional change in the actual waveguides geometry. This result is used as a way for improving quality control over the waveguide dimensions obtained from the photolithographic and RIE processes.
ORIGINAL COMMUNICATION Structure and organisation of 47 nutrition support teams in Germany: a prospective investigation in 2000 German hospitals in 1999 (2003)

Department of Surgery, Ruhr UniversityBochum, GermanyObjective: Evaluation. Contrary to the Anglo-American region, very little is known in Germany on the structure and organisationof nutrition support teams (NST).Design: Prospective investigation of the structure and organisation of German NST, using standardised interview questionnaires.Settings: Hospitals with more than 250 beds in Germany.Subjects: German NST (n¼47).Interventions: Face-to-face interview in 1999, using a standardised questionnaire.Results: From a total of 2000 German hospitals, NST have been established at 47 hospitals (2.3%). Most NST are affiliated to alarge university hospital or an academic teaching hospital. In general, the NST are not independently operating units but areaffiliated to a special discipline, and were in operation for an average of 8y. The NST cared for a median of 65 outpatientsannually. At the university hospitals in average, 477 in-patients were treated per year, at the teaching hospitals 400 and at allother hospitals 179. The work of the NST centred on enteral nutrition. A total of 47% of the physicians, 19% of the nurses and19% of the dietitians in the NST held a nutrition-specific additional qualification. A total of 2% of the physicians, 68% of thenurses and 77% of the dietitians are exclusively responsible for the NST. More than 70% of the financing of the personnel wassecured through third-party funds.Conclusion: In Germany, neither uniform nor comprehensive patient care by NST existed in 1999. More than 50% of all NSTmembers do not hold a nutrition-specific additional qualification. Frequently, besides their tasks in the team, the NST staff alsocarries out other clinical functions. Contrary to the American NST, the German NST are not interdisciplinary operating units butare primarily financed through third-party funds of the industry.European Journal of Clinical Nutrition (2003) 57, 1311–1316. doi:10.1038/sj.ejcn.1601693
Correction to Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular Localization (2013)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Cell-Selective Biological Activity of Rhodium Metalloinsertors Correlates with Subcellular LocalizationAlexis C. Komor, Curtis J. Schneider, Alyson G. Weidmann, and Jacqueline K. Barton*Cite this: J. Am. Chem. Soc. 2013, 135, 7, 2863Publication Date (Web):February 8, 2013Publication History Published online8 February 2013Published inissue 20 February 2013https://pubs.acs.org/doi/10.1021/ja400471qhttps://doi.org/10.1021/ja400471qcorrectionACS PublicationsCopyright © 2013 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views820Altmetric-Citations1LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (130 KB) Get e-Alertsclose Get e-Alerts
Observing Collective Plasma Effects in Beam-Driven QED Cascades via Laser Frequency Upconversion (2020)

In extremely strong laser fields, highly energetic particles can induce electron-positron pair production in vacuum. With existing technology, an electron-positron pair plasma can be produced through an exponentially growing QED cascade. However, it is extremely challenging to verify experimentally that an actual plasma has been formed, i.e. that collective effects play a role. Here, we suggest frequency upconversion in the driving laser pulse as an unambiguous experimental signature of collective behavior. The pair plasma created in the QED cascade suddenly changes the optical refractive index depending on the plasma density, thereby upshifting the driving laser frequency. In particular, QED-PIC simulations demonstrate that the frequency upshift would be detectable if electron beams on the 30 GeV scale interact with 10 PW-class optical laser pulses, which is in reach of laboratory devices with moderate upgrades.
T lymphocyte subsets in primary antiphospholipid syndrome. (1994)

Blood T cells phenotypes in primary APS differ markedly from healthy controls, indicating that immunologic abnormalities in primary APS might extend beyond autoantibody production.
Increase in chitin as an essential response to defects in assembly of cell wall polymers in the ggp1delta mutant of Saccharomyces cerevisiae (1997)

The GGP1/GAS1 gene codes for a glycosylphosphatidylinositol-anchored plasma membrane glycoprotein of Saccharomyces cerevisiae. The ggp1delta mutant shows morphogenetic defects which suggest changes in the cell wall matrix. In this work, we have investigated cell wall glucan levels and the increase of chitin in ggp1delta mutant cells. In these cells, the level of alkali-insoluble 1,6-beta-D-glucan was found to be 50% of that of wild-type cells and was responsible for the observed decrease in the total alkali-insoluble glucan. Moreover, the ratio of alkali-soluble to alkali-insoluble glucan almost doubled, suggesting a change in glucan solubility. The increase of chitin in ggp1delta cells was found to be essential since the chs3delta ggp1delta mutations determined a severe reduction in the growth rate and in cell viability. Electron microscopy analysis showed the loss of the typical structure of yeast cell walls. Furthermore, in the chs3delta ggp1delta cells, the level of alkali-insoluble glucan was 57% of that of wild-type cells and the alkali-soluble/alkali-insoluble glucan ratio was doubled. We tested the effect of inhibition of chitin synthesis also by a different approach. The ggp1delta cells were treated with nikkomycin Z, a well-known inhibitor of chitin synthesis, and showed a hypersensitivity to this drug. In addition, studies of genetic interactions with genes related to the construction of the cell wall indicate a synthetic lethal effect of the ggp1delta kre6delta and the ggp1delta pkc1delta combined mutations. Our data point to an involvement of the GGP1 gene product in the cross-links between cell wall glucans (1,3-beta-D-glucans with 1,6-beta-D-glucans and with chitin). Chitin is essential to compensate for the defects due to the lack of Ggp1p. Moreover, the activities of Ggp1p and Chs3p are essential to the formation of the organized structure of the cell wall in vegetative cells.
Neutron-encoded Signatures Enable Product Ion Annotation From Tandem Mass Spectra (2013)

We report the use of neutron-encoded (NeuCode) stable isotope labeling of amino acids in cell culture for the purpose of C-terminal product ion annotation. Two NeuCode labeling isotopologues of lysine, (13)C6(15)N2 and (2)H8, which differ by 36 mDa, were metabolically embedded in a sample proteome, and the resultant labeled proteins were combined, digested, and analyzed via liquid chromatography and mass spectrometry. With MS/MS scan resolving powers of ~50,000 or higher, product ions containing the C terminus (i.e. lysine) appear as a doublet spaced by exactly 36 mDa, whereas N-terminal fragments exist as a single m/z peak. Through theory and experiment, we demonstrate that over 90% of all y-type product ions have detectable doublets. We report on an algorithm that can extract these neutron signatures with high sensitivity and specificity. In other words, of 15,503 y-type product ion peaks, the y-type ion identification algorithm correctly identified 14,552 (93.2%) based on detection of the NeuCode doublet; 6.8% were misclassified (i.e. other ion types that were assigned as y-type products). Searching NeuCode labeled yeast with PepNovo(+) resulted in a 34% increase in correct de novo identifications relative to searching through MS/MS only. We use this tool to simplify spectra prior to database searching, to sort unmatched tandem mass spectra for spectral richness, for correlation of co-fragmented ions to their parent precursor, and for de novo sequence identification.
TMEM258 Is a Component of the Oligosaccharyltransferase Complex Controlling ER Stress and Intestinal Inflammation (2016)

Significant insights into disease pathogenesis have been gleaned from population-level genetic studies; however, many loci associated with complex genetic disease contain numerous genes, and phenotypic associations cannot be assigned unequivocally. In particular, a gene-dense locus on chromosome 11 (61.5-61.65 Mb) has been associated with inflammatory bowel disease, rheumatoid arthritis, and coronary artery disease. Here, we identify TMEM258 within this locus as a central regulator of intestinal inflammation. Strikingly, Tmem258 haploinsufficient mice exhibit severe intestinal inflammation in a model of colitis. At the mechanistic level, we demonstrate that TMEM258 is a required component of the oligosaccharyltransferase complex and is essential for N-linked protein glycosylation. Consequently, homozygous deficiency of Tmem258 in colonic organoids results in unresolved endoplasmic reticulum (ER) stress culminating in apoptosis. Collectively, our results demonstrate that TMEM258 is a central mediator of ER quality control and intestinal homeostasis.
EWA volume splatting (2005)

In this paper we present a novel framework for direct volume rendering using a splatting approach based on elliptical Gaussian kernels. To avoid aliasing artifacts, we introduce the concept of a resampling filter combining a reconstruction with a low-pass kernel. Because of the similarity to Heckbert's EWA (elliptical weighted average) filter for texture mapping we call our technique EWA volume splatting. It provides high image quality without aliasing artifacts or excessive blurring even with non-spherical kernels. Hence it is suitable for regular, rectilinear, and irregular volume data sets. Moreover, our framework introduces a novel approach to compute the footprint function. It facilitates efficient perspective projection of arbitrary elliptical kernels at very little additional cost. Finally, we show that EWA volume reconstruction kernels can be reduced to surface reconstruction kernels. This makes our splat primitive universal in reconstructing surface and volume data.