gebhart/patrepeval huggingface dataset:
Coordination Chemistry of H<sub>2</sub> and N<sub>2</sub> in Aqueous Solution. Reactivity and Mechanistic Studies Using <i>trans</i>-Fe<sup>II</sup>(P<sub>2</sub>)<sub>2</sub>X<sub>2</sub>-Type Complexes (P<sub>2</sub> = a Chelating, Water-Solubilizing Phosphine) (2007)

The reactions of the trans-Fe(DMeOPrPE)2Cl2 complex (I; DMeOPrPE = 1,2-bis(bis(methoxypropyl)phosphino)ethane) and its derivatives were studied in aqueous and nonaqueous solvents with a particular emphasis on the binding and activation of H2 and N2. The results show there are distinct differences in the reaction pathways between aqueous and nonaqueous solvents. In water, I immediately reacts to form trans-Fe(DMeOPrPE)2(H2O)Cl+. Subsequent reaction with H2 or N2 yields trans-Fe(DMeOPrPE)2(X2)Cl+ (X2=H2 or N2). In the case of H2, further reactivity occurs to ultimately give the trans-Fe(DMeOPrPE)2(H2)H+ product (III). The pathway for the reaction I --> III was spectroscopically examined: following the initial loss of chloride and replacement with H2, heterolysis of the H2 ligand occurs to form Fe(DMeOPrPE)2(H)Cl; substitution of the remaining chloride ligand by another H2 molecule then occurs to produce trans-Fe(DMeOPrPE)2(H2)H+. In the absence of H2 or N2, trans-Fe(DMeOPrPE)2(H2O)Cl+ slowly reacts in water to form Fe(DMeOPrPE)32+, II. Experiments showed that this species forms by reaction of free DMeOPrPE ligand with trans-Fe(DMeOPrPE)2(H2O)Cl+, where the free DMeOPrPE ligand comes from dissociation from the trans-Fe(DMeOPrPE)2(H2O)Cl+ complex. In nonaqueous solvents, the chloride ligand in I is not labile, and a reaction with H2 only occurs if a chloride abstracting reagent is present. Complex III is a useful synthon for the formation of other water-soluble metal hydrides. For example, the trans-[Fe(DMeOPrPE)2H(N2)]+ complex was generated in H2O by substitution of N2 for the H2 ligand in III. The trans-Fe(DHBuPE)2HCl complex (DHBuPE = 1,2-bis(bis(hydroxybutyl)phosphino)ethane, another water-solubilizing phosphine) was shown to be a viable absorbent for the separation of N2 from CH4 in a pressure swing scheme. X-ray crystallographic analysis of II is the first crystal structure report of a homoleptic tris chelate of FeII containing bidentate phosphine ligands. The structure reveals severe steric crowding at the Fe center.
Developpement d'outils lipidiques partiellement perfluores pour la cristallisation bidimensionnelle de proteines. Application aux recepteurs de l'acide retinoique et a des proteines membranaires (1999)

Ce manuscrit presente la synthese et la conception de nouveaux outils concus pour la cristallisation bidimensionnelle de proteines sur film lipidique specifique. Nous avons developpe, pour le cas particulier de proteines solubles a ligand hydrophobe (en l'occurence les recepteurs de l'acide retinoique) deux concepts originaux afin d'eviter l'insertion dans la monocouche d'un tel ligand greffe au support lipidique. Ces deux approches font intervenir respectivement des amphiphiles dits thermoambivalents (avec une temperature de transition de phase comprise entre 4 et 20\c) capables, a faible temperature, d'expulser mecaniquement le ligand de la monocouche et des lipides partiellement perfluores possedant un caractere suffisamment lipophobe pour contraindre le ligand a s'exprimer en phase aqueuse et rester accessible a la proteine. Les deux concepts ont ete valides et nous avons mis en evidence le premier exemple d'immobilisation a l'interface air/eau d'une proteine soluble a ligand hydrophobe. Cependant, jusqu'ici, nos tentatives de cristallisation bidimensionnelle d'un heterodimere rar/rxr ont abouti uniquement a la formation d'arrangements compacts de proteines. Dans la seconde partie de ce travail, nous avons tente de tirer profit des proprietes de segregation de phases entre fluorocarbures et hydrocarbures, pour developper d'autres supports lipidiques fluores impermeables aux detergents, et ainsi, utilisables dans des protocoles de cristallisation bidimensionnelle de proteines membranaires sur film specifique. La bonne stabilite des amphiphiles prepares en presence de divers tensioactifs a pu etre determinee par ellipsometrie. Par ailleurs, cette technique a permis de montrer sans ambiguite l'adsorption rapide d'une proteine membranaire vegetale (une monooxygenase a cytochrome p450) sur un tel film d'amphiphiles partiellement fluores et nous avons recemment entrepris une serie d'experiences de cristallisation bidimensionnelle de deux enzymes a cytochrome p450 sur les supports lipidiques fluores synthetises.
Non-invasive imaging of epileptic seizures<i>in vivo</i>using photoacoustic tomography (2008)

Non-invasive laser-induced photoacoustic tomography (PAT) is an emerging imaging modality that has the potential to image the dynamic function of the brain due to its unique ability of imaging biological tissues with high optical contrast and ultrasound resolution. Here we report the first application of our finite-element-based PAT for imaging of epileptic seizures in an animal model. In vivo photoacoustic images were obtained in rats with focal seizures induced by microinjection of bicuculline, a GABA(A) antagonist, into the neocortex. The seizure focus was accurately localized by PAT as confirmed with gold-standard electroencephalogram (EEG). Compared to the existing neuroimaging modalities, PAT not only has the unprecedented advantage of high spatial and temporal resolution in a single imaging modality, but also is portable and low in cost, making it possible to bring brain imaging to the bedside.
Lithium/organosulfur redox cell having protective solid electrolyte barrier formed on anode and method of making same (2023)

A lithium/organosulfur redox cell is disclosed which comprises a solid lium anode, a liquid organosulfur cathode, and a barrier layer formed adjacent a surface of the solid lithium anode facing the liquid organosulfur cathode consisting of a reaction product of the lithium anode with the organosulfur cathode. The organosulfur cathode comprises a material having the formula (R(S).sub.y).sub.N where y=1 to 6, n=2 to 20 and R is one or more different aliphatic or aromatic organic moieties having 1 to 20 carbon atoms, which may include one or more oxygen, sulfur, nitrogen, or fluorine atoms associated with the chain when R comprises an aliphatic chain, wherein the linear chain may be linear or branched, saturated or unsaturated, and wherein either the aliphatic chain or the aromatic ring may have substituted groups thereon.
Synthesis and Pharmacological Evaluation of Aminothiazolomorphinans at the Mu and Kappa Opioid Receptors (2013)

Previous studies with aminothiazolomorphinans suggested that this class of opioid ligands may be useful as a potential pharmacotherapeutic to decrease drug abuse. Novel aminothiazole derivatives of cyclorphan were prepared to evaluate a series of aminothiazolomorphinans with varying pharmacological properties at the κ opioid receptor (KOR) and μ opioid receptor (MOR). This study was focused on exploring the regioisomeric analogs with the aminothiazole on the C-ring of the morphinan skeleton. Receptor binding and [(35)S]GTPγS binding assays were used to characterize the affinity and pharmacological properties of the aminothiazolomorphinans. Intracranial self-stimulation (ICSS) was used to compare the effects of a representative aminothiazolomorphinan with the morphinan mixed-KOR/MOR agonist butorphan (MCL-101) on brain-stimulation reward.
Visual consequences of Albinism (2015)

Purpose: The purpose of this thesis is to provide a comprehensive literature review about albinism as an inherited metabolic disorder of melanin synthesis along with those related conditions impacting the visual system. As such, it addresses eye care emphasizing the visual consequences of albinism along with diagnostic and treatment options. Methods: Background knowledge about ocular development is given as well as information about etiological biochemical and genetic processes. The current classification, clinical findings and their assessment and management options are presented based on recent results of research. In conclusion, two case reports are described as examples of visual care options. Results: Melanin plays a big role in the retinal and chiasmal development. Melanin biosynthesis can be disrupted by different genes in various ways which leads to the current classification of albinism. Clinical findings include fundus hypopigmenta-tion, nystagmus, iris transillumination, photophobia, foveal hypoplasia, excessive chiasmal decussation, reduced visual acuity, high astigmatism (with-the-rule), strabismus and decreased stereopsis. Treatment options to improve visual acuity, fixation and binocularity are (tinted) prescription lenses and contact lenses, low vision aids, surgical procedures and vision therapy. Medication and supplementa-tion for increased pigmentation are currently being tested on mice. Conclusions: Albinism is caused by genetic mutations resulting in ocular and cutaneous hypopigmentation. It establishes various phenotypes that require different therapy approaches in order to improve vision and therefore quality of life.
Silica Molecular Dynamic Force Fields- A Practical Assessment (2010)

The purpose of this paper is to compare simple and efficient pair-wise force fields for silica glass and assess their applicability for use in large scale molecular dynamic (MD) simulations of laser damage mitigation. A number of pair-wise force fields have been shown to give the random tetrahedral network of silica glass. Further, potentials obtained by fitting quantum mechanical results exhibit many of the properties of silica such as the low thermal expansion and densification. However with these potentials densification is observed at temperatures much higher than experiment. We also show that the thermodynamic melting point of β-crystobalite similarly occurs at temperatures much higher than observed experimentally. Softer empirical potentials can be constructed that do give liquid properties at experimental temperatures. However in all cases the activation energies for diffusion are lower than the experimental activation energies for viscosity.
Three-dimensional interaction of a finite-span synthetic jet in a crossflow (2016)

The formation and evolution of flow structures due to the interaction of a finite-span synthetic jet with a zero-pressure gradient laminar boundary layer were experimentally investigated using stereoscopic particle image velocimetry. A synthetic jet with three orifice aspect ratios of AR = 6, 12, and 18 was issued into a free-stream velocity of U∞ = 10 m/s (Reδ = 2000) at blowing ratios of Cb = 0.5–1.5. The interaction was found to be associated with two sets of flow structures: (1) a recirculation region downstream of the orifice due to virtual blockage, and (2) a steady streamwise vortex pair farther downstream. These two flow structures were characterized in detail. Tube-like velocity deficits in the free-stream were evident, as well as regions of increased velocity within the boundary layer. Reducing the aspect ratio of the orifice decreased the spacing of the edgewise vortices (generated due to the finite span of the orifice) as well as reducing the virtual blockage of the jet. A control volume analysis of the fluid streamwise momentum indicates that there is a momentum deficit just downstream of the jet orifice and the change in streamwise momentum is proportionally similar for all cases.
Double pulse approach of electrogenotherapy: an analysis at the single cell level (2008)

Plasmid Gene transfer and expression can be obtained by the application of electric pulses to a mixture of cells and plasmids (electrogenetherapy, EGT). By using population assay and single cell fluorescence investigations, we have some details on the process bringing the plasma membrane transfer. Plasmids were brought electrophoretically in contact with the cell surface during the pulse and formed local aggregates which were slowly transferred in the cytoplasm after the pulse. But, clearly, the transfer to and across the nuclear envelope remains a problem. A biological approach showed that EGT was more effective along mitosis as expected. The group at ODU showed that nanosecond pulses may affect the organelles (such as the nucleus). Therefore we made an approach of the alteration of the nucleus induced by a HV pulse (up to 9 kV/cm) lasting 5 microseconds a few second after EGT (0.7 kV/cm, 5 ms) needed to introduce the plasmid in the cytoplasm. This was obtained by a digitized fluorescence method at the single cell level by using probes with a high affinity to the nucleus.
Bio-activating ultrafine grain titanium: RNA sequencing reveals enhanced mechano-activation of osteoconduction on nanostructured substrates (2020)

Titanium is essentially absent from biological systems yet reliably integrates into bone. To achieve osseointegration, titanium must activate biological processes without entering cells, defining it as a bio-activating material. Nanostructuring bulk titanium reduces grain size, increases strength, and improves other quantifiable physical properties, including cytocompatibility. The biological processes activated by increasing grain boundary availability were detected with total RNA-sequencing in mouse pre-osteoblasts grown for 72 hours on nanometrically smooth substrates of either coarse grain or nanostructured ultrafine grain titanium. The average grain boundary length under cells on the conventional coarse grain substrates is 273.0 μm, compared to 70,881.5 μm for cells adhered to the nanostructured ultrafine grain substrates; a 260-fold difference. Cells on both substrates exhibit similar expression profiles for genes whose products are critical for mechanosensation and transduction of cues that trigger osteoconduction. Biological process Gene Ontology term enrichment analysis of differentially expressed genes reveals that cell cycle, chromatin modification, telomere maintenance, and RNA metabolism processes are upregulated on ultrafine grain titanium. Processes related to immune response, including apoptosis, are downregulated. Tumor-suppressor genes are upregulated while tumor-promoting genes are downregulated. Upregulation of genes involved in chromatin remodeling and downregulation of genes under the control of the peripheral circadian clock implicate both processes in the transduction of mechanosensory information. Non-coding RNAs may also play a role in the response. Merging transcriptomics with well-established mechanobiology principles generates a unified model to explain the bio-activating properties of titanium. The modulation of processes is accomplished through chromatin remodeling in which the nucleus responds like a rheostat to grain boundary concentration. This convergence of biological and materials science reveals a pathway toward understanding the biotic-abiotic interface and will inform the development of effective bio-activating and bio-inactivating materials.
Data from Blocking SHH/Patched Interaction Triggers Tumor Growth Inhibition through Patched-Induced Apoptosis (2023)

&lt;div&gt;Abstract&lt;p&gt;The Sonic Hedgehog (SHH) pathway plays a key role in cancer. Alterations of SHH canonical signaling, causally linked to tumor progression, have become rational targets for cancer therapy. However, Smoothened (SMO) inhibitors have failed to show clinical benefit in patients with cancers displaying SHH autocrine/paracrine expression. We reported earlier that the SHH receptor Patched (PTCH) is a dependence receptor that triggers apoptosis in the absence of SHH through a pathway that differs from the canonical one, thus generating a state of dependence on SHH for survival. Here, we propose a dual function for SHH: its binding to PTCH not only activates the SHH canonical pathway but also blocks PTCH-induced apoptosis. Eighty percent, 64%, and 8% of human colon, pancreatic, and lung cancer cells, respectively, overexpressed SHH at transcriptional and protein levels. In addition, SHH-overexpressing cells expressed all the effectors of the PTCH-induced apoptotic pathway. Although the canonical pathway remained unchanged, autocrine SHH interference in colon, pancreatic, and lung cell lines triggered cell death through PTCH proapoptotic signaling. &lt;i&gt;In vivo&lt;/i&gt;, SHH interference in colon cancer cell lines decreased primary tumor growth and metastasis. Therefore, the antitumor effect associated to SHH deprivation, usually thought to be a consequence of the inactivation of the canonical SHH pathway, is, at least in part, because of the engagement of PTCH proapoptotic activity. Together, these data strongly suggest that therapeutic strategies based on the disruption of SHH/PTCH interaction in SHH-overexpressing cancers should be explored.&lt;/p&gt;Significance:&lt;p&gt;Sonic Hedgehog–overexpressing tumors express PTCH-induced cell death effectors, suggesting that this death signaling could be activated as an antitumor strategy.&lt;/p&gt;&lt;/div&gt;
Performance of AHEAD Score in an Asian Cohort of Acute Heart Failure With Either Preserved or Reduced Left Ventricular Systolic Function (2017)

The AHEAD score was useful in predicting long-term mortality in the Asian acute heart failure cohort with either HFrEF or HFpEF. The new AHEAD-U score may further improve risk stratification.
Digital-based interleaving control for GaN-based MHz CRM totem-pole PFC (2016)

In this paper, the performance of different interleaving control methods for gallium-nitride (GaN) devices based MHz critical conduction mode (CRM) totem-pole power factor correction (PFC) circuit is compared. Both closed-loop interleaving and open-loop interleaving are good for low frequency CRM PFC; but for MHz very high frequency CRM PFC with microcontroller (MCU) implementation, open-loop interleaving outperforms closed-loop interleaving with small and non-amplified phase error. After software optimization, the phase error of open-loop interleaving is smaller than 3 degree at 1MHz, when the control is implemented by 60MHz low cost MCU. Significant ripple cancellation effect and differential-mode (DM) filter size reduction is achieved with good interleaving. For a 1.2kW MHz totem-pole PFC, the DM filter size is reduced to one quarter compared to the counterpart of a 100kHz PFC. Last but not least, the stability of open-loop interleaving is also analyzed indicating that the MHz CRM totem-pole PFC with voltage-mode control, open-loop interleaving, and turn-on instant synchronization can maintain critical mode operation with better stability compared to low frequency CRM PFC.
Building a Web of Things (2013)

The massive number of Internet of Things (IoT) end devices described in the preceding chapter will be producing and consuming prodigious amounts of simple data in the form of terse chirps (see Chapter 2). But if these chirps, as described, lack the traditional overhead trappings of well-known protocols such as TCP/IP, how can they be moved across the traditional Internet—or indeed, across any network at all?
ChemInform Abstract: Phenanthrenequinone Antiretroviral Agents. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Bending of DNA by the Mitomycin C-Induced, GpG Intrastrand Cross-Link (1996)

Mitomycin C (MC) forms interstrand and intrastrand cross-link adducts and monoalkylation products (monoadducts) with DNA. Each of the three types of adducts was incorporated site-specifically into both a 15-mer and a 21-mer oligodeoxyribonucleotide duplex. The adduct-containing duplexes were 32P-phosphorylated and ligated to form multimers, which were then analyzed for anomalous electrophoretic mobility by nondenaturing polyacrylamide gel electrophoresis, using the method of Koo and Crothers [(1988) Proc. Natl. Acad. Sci. U.S.A. 85, 1763-1767] in order to detect DNA curvature caused by the adducts. The intrastrand cross-link adduct was found to induce a 14.6 +/- 2.0 degrees DNA bend per lesion (minimum value) while no DNA bending was detected for either the interstrand cross-link or the monoadduct. Molecular mechanics modeling indicated that the possible origin of the bend lies in a considerable deviation from parallel of the normals to the best planes of the intrastrand cross-linked guanines, due to a shorter than normal distance between their N2 atoms forced upon them by the cross-link. The observed bending by the MC intrastrand lesion may be the cause of the increased flexibility of MC-modified DNA, localized to distinct regions, as observed in earlier work by hydrodynamic methods and electron microscopy. The MC adduct-caused DNA bend may serve as a recognition site for certain DNA-binding proteins.
Lightly-supervised utterance-level emotion identification using latent topic modeling of multimodal words (2016)

Research on multimodal emotion recognition has drawn much attention recently in diverse disciplines. With the increasing amount of multimodal data, unsupervised or semi-supervised learning has become highly desirable to automatically discover expression of emotion patterns in behavioral data. We present a novel approach for multimodal emotion learning using only a small amount of labels. Our approach is hinging on probabilistic latent semantic analysis (pLSA) that defines the latent variable as the emotion class, motivated by the conceptualization that human emotion acts as a latent control variable that regulates the external behavior manifestations, such as through speech and body gesture. In our approach, we represent the audio-visual information in an utterance as a bag of multimodal words. To exploit the interrelation between speech and gesture modalities, we propose a canonical correlation analysis (CCA) based vocabulary of multimodal words. Our approach has achieved promising experimental results. We have also demonstrated the superiority of the CCA-based multimodal words over those derived directly from the original cues.
Comparison of wavelet image coding schemes for seismic data compression (1997)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 1997Comparison of wavelet image coding schemes for seismic data compressionAuthors: Anthony VassiliouVictor WickerhauserAnthony VassiliouAmoco Production Company and Victor WickerhauserWashington University at St. Louishttps://doi.org/10.1190/1.1885651 SectionsAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Permalink: https://doi.org/10.1190/1.1885651FiguresReferencesRelatedDetailsCited by1-ADM-CNN: A Lightweight In-field Compression Method for Seismic DataIEEE Transactions on Circuits and Systems II: Express Briefs, Vol. 69, No. 12Seismic Data Compression Using Deep LearningIEEE Access, Vol. 9Multidimensional Seismic Compression by Hybrid Transform with Multiscale-Based Coding25 August 2015Multidimensional Seismic Compression by Hybrid Transform with Multiscale-Based Coding26 August 2014Multidimensional Seismic Compression by Hybrid Transform with MultiscaleBased CodingApplication of 2nd generation wavelets to seismic imagingDimitri Bevc, David L. Donoho, and Sergio E. Zarantonello3 January 2005Using standard image compression algorithms to store data from computational fluid dynamicsComputers & Geosciences, Vol. 29, No. 8Low bit-rate efficient compression for seismic dataIEEE Transactions on Image Processing, Vol. 10, No. 12 SEG Technical Program Expanded Abstracts 1997ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 1997 Pages: 2067 publication data© 1997 Copyright © 1997 Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 10 Feb 2005 CITATION INFORMATION Anthony Vassiliou and Victor Wickerhauser, (1997), "Comparison of wavelet image coding schemes for seismic data compression," SEG Technical Program Expanded Abstracts : 1334-1337. https://doi.org/10.1190/1.1885651 Plain-Language Summary PDF DownloadLoading ...