gebhart/patrepeval huggingface dataset:
Novel therapeutic targets for nonalcoholic fatty liver disease (2013)

There is an urgent need to develop novel safe and effective therapies for the growing NAFLD epidemic. The data discussed in this article provide strong rational to think out of the box when considering novel therapeutic targets for patients with NAFLD.
Prospective Comparison of <sup>18</sup> F-Fluoromethylcholine Versus <sup>68</sup> Ga-PSMA PET/CT in Prostate Cancer Patients Who Have Rising PSA After Curative Treatment and Are Being Considered for Targeted Therapy (2015)

In patients with biochemical failure and a low PSA level, (68)Ga-PSMA demonstrated a significantly higher detection rate than (18)F-fluoromethylcholine and a high overall impact on management.
Extracting internal modes of top emission organic light emitting diodes by using internal random mesoscopic wrinkles (2021)

Angular electroluminescence spectra stabilized and efficiency enhanced top-emitting organic light-emitting devices (TOLEDs) were demonstrated using randomly distributed mesoscopic internal wrinkles. Compared to planar TOLEDs, wrinkled TOLEDs showed a faster exciton decay rate in the emissive layer and high rate of radiative recombination, which leads to enhanced efficiency. Our wrinkled TOLEDs showed angular spectral dependency (u′v′(θ)) of 0.0032, which is low enough to be imperceptible to the human eyes, and 38.7 % enhanced external quantum efficiency relative to the planar counterpart. The approach described here provides an effective scheme for improving TOLEDs and obviating the necessity of modifying the stack structure of the device.
High Accuracy Adaptive Microwave Ranging Using SNR-Based Perception for Coherent Distributed Antenna Arrays (2020)

We present a high accuracy, adaptive cooperative internode ranging system for coherent distributed antenna arrays. Coherent distributed antenna arrays are networks of wireless systems coordinated at the level of the wavelength of the wireless signal to support distributed beamforming. Enabling coherent operation between separate mobile nodes at microwave frequencies requires accurate and robust knowledge of the relative positions of the nodes in the array in the presence of changing conditions. We present an adaptive microwave ranging system operating at 4 GHz that is capable of maintaining a designated ranging accuracy in the presence of changing signal-to-noise ratio (SNR) conditions. The system is based on a novel perception process that evaluates the SNR of the radar returns and estimates the accuracy of the internode ranging measurement; the output of this process feeds into a controller which determines the changes necessary in the waveform to maintain the desired accuracy. Experimental results show the ability to maintain ranging accuracy of 5 mm, which enables 90% of the ideal distributed coherent gain at frequencies up to 4 GHz.
‘Design of UWB Antennas Integrating Geopolymer Material’ (2018)

International audience
AUTOMAÇÃO PREDIAL COM UTILIZAÇÃO DE CONTROLADOR (2011)

Para o controle dos circuitos de iluminação e circuitos de temperatura predial, é muito comum, encontrar em vários estabelecimentos brasileiros, o uso de diversos sistemas independentes de automação com a utilização de sensores que são totalmente controlados por seus proprietários, que além de gerar transtornos e esquecimentos quanto a seus acionamentos, podem com isto acarretar possíveis desperdícios de energia elétrica. Alguns aspectos importantes como temperatura, cor das lâmpadas, rendimento das luminárias, rendimento do reator utilizado e eficiência luminosa das lâmpadas são de extrema importância para um projeto que visa obter resultados voltados para a eficiência energética. Este artigo tem como objetivo, propor a automatização do acionamento dos circuitos de iluminação e ventiladores das salas de aula do Centro Universitário de Belo Horizonte – UniBH, visando a eficientização energética em termos de: redução do consumo de energia, custo de manutenção, maior vida útil das lâmpadas e maior eficiência luminosa. Pretende-se propor com a adoção do CLP uma redução significativa no consumo de energia, apenas evitando o desperdício.
Induction of cell cycle arrest in DU145 human prostate cancer cells by the dietary compound piceatannol (2008)

Piceatannol (3,4,3′,5′‐tetrahydroxystilbene) is a naturally occurring polyphenol and analog of the cancer chemopreventive agent resveratrol (3,5,4′‐trihydroxystilbene). Piceatannol is present in the skins of grapes, rhubarb, and sugar cane and is known to have anti‐inflammatory and anti‐carcinogenic activity. In the present study, we examined piceatannol‐mediated regulation of cell cycle progression in androgen‐insensitive DU145 human prostate cancer cells. Cells were treated with 0–10 μM piceatannol. The percentage of cells in G1 phase was increased in cells treated with piceatannol for 24 h. Piceatannol decreased incorporation of [ 3 H]thymidine into DNA. Piceatannol decreased the protein levels of cyclin A, and cyclin D1. In addition, cyclin‐dependent kinase (CDK)2 and CDK4 protein levels decreased in cell treated with piceatannol. But piceatannol did not affect the expression of the CDK inhibitor p21 or p27. The activity of CDK2 and CDK4 decreased following piceatannol treatment in a concentration‐dependent manner. The present results indicate that piceatannol inhibits the growth of DU145 cell growth by delaying G1 cell cycle progression, which may be mediated via inhibition of CDK activities.
Potential of Using Night-Time Light to Proxy Social Indicators for Sustainable Development (2023)

Satellite-observed night-time light (NTL) data provide a measure of the lighting brightness seen from space at different times and spatial and temporal resolutions, thus offering opportunities to explore them in many applications at different spatial locations (global, regional, local). However, most applications to date have been at relatively large spatial scales, despite the need to measure indicators at a local level. This paper sets out an analysis of the potential of NTL data for populating indicators at more local (neighbourhood, street) scales. We first reviewed the overall potential of NTL data for social indicators at different spatial scales by using a systematic search of the literature and applying the Maturity Matrix Framework (MMF). We also explored a case study (Durango State, Mexico) using Visible Infrared Imaging Radiometer Suite (VIIRS) imageries, other geospatial data, and the social gap index (SGI) to identify social gaps at the local scale. The literature review showed that NTL can play a role in supporting 49 out of 192 sustainable development goal (SDG) indicators having a focus on social issues, but most of these have been explored at the global or country scales. In the case study, we found that low radiance is indeed associated with higher SGI levels (i.e., more social deprivation) and vice versa. However, more research is needed from other contexts to support a link between NTL radiance levels and social indicators at local scales.
Oxygen and Oxidation Promote the Release of Nitric Oxide from Sydnonimines (1989)

Journal of Cardiovascular Pharmacology™ is a peer reviewed, multidisciplinary journal that publishes original articles and pertinent review articles on basic and clinical aspects of cardiovascular pharmacology. Appropriate subjects include new drug development and evaluation, physiological and pharmacological bases of drug action, metabolism, drug interactions and side effects, clinical results with new and established agents and novel methods. The focus is on pharmacology in its broadest applications, incorporating not only traditional approaches, but new approaches to the development of pharmacological agents and the prevention and treatment of cardiovascular diseases.
Safety and immunogenicity of Salmonella typhi Ty21a vaccine in young Thai children (1993)

Salmonella typhi Ty21a vaccine in a liquid formulation was evaluated in 634 Thai children 2 to 6 years of age. The seroconversion rate was 69% for those who received vaccine versus 14% for those who received placebo (P < 0.005). The immune responses among vaccine recipients ranged from 60% in 3-year-olds to 81% for 6-year-olds.
Heat shock proteins are methylated in avian and mammalian cells. (1981)

Exposure of chicken cells grown in tissue culture to heat shock or sodium arsenite results in a dramatic increase in the synthesis of three major polypeptides with molecular weights of 83,000 (HSP 83), 68,000 (HSP 68; referred to here as "thermin"), and 25,000 (HSP 25). Incubation of BHK-21 or HeLa cells under the same conditions results in induction of HSP 68 and a 66,000-dalton polypeptide (HSP 66). Chicken thermin is resolved by isoelectric focusing into a major acidic and a more-basic component; mammalian thermin is resolved only into one major acidic component. HSP 83 and the acidic form of thermin are highly conserved in all avian and mammalian cells examined as judged by their electrophoretic mobilities, isoelectric points, and one-dimensional peptide maps. In addition, the acidic form of thermin is indistinguishable from a protein that copurifies with brain microtubules and that remains associated with the intermediate filament-enriched Triton/KCl cytoskeletons of cells grown in tissue culture. Thermin is also a component of skeletal myofibrils. HSP 83 and thermin are methylated in cells cultured under normal growth conditions. Induction of heat shock proteins by incubation of cells in the presence of sodium arsenite results in a marked methylation of the newly synthesized thermin. Under the same experimental conditions, no significant increase in methylation of the HSP 83 is observed. HSP 25 is not methylated in untreated cells or in cells treated with sodium arsenite. These results suggest that methylation of heat shock proteins may have an important role in regulating their function.
Venoarterial Extracorporeal Membrane Oxygenation Support for Ventricular Tachycardia Ablation: A Systematic Review (2020)

Refractory ventricular tachycardia (VT) and electrical storm are frequently associated with hemodynamic compromise requiring mechanical support. This study sought to review the current literature on the use of venoarterial extracorporeal membrane oxygenation (VA-ECMO) for hemodynamic support during VT ablation. This was a systematic review of all published literature from 2000 to 2019 evaluating patients with VT undergoing ablation with VA-ECMO support. Studies that reported mortality, safety, and efficacy outcomes in adult (>18 years) patients were included. The primary outcome was short-term mortality (intensive care unit stay, hospital stay, or ≤30 days). The literature search identified 4,802 citations during the study period, of which seven studies comprising 867 patients met the inclusion criteria. Periprocedural VA-ECMO was used in 129 (15%) patients and all were placed peripherally. Average inducible VTs were 2-3 per procedure and ablation time varied between 34 mins and 4.7 hours. Median ages were between 61 and 68 years with 93% males. Median duration of VA-ECMO varied between 140 minutes and 6 days. Short-term mortality was 15% (19 patients), with the most frequent causes being refractory VT, cardiac arrest, and acute heart failure. All-cause mortality at the longest follow-up was 25%. Major bleeding, vascular/access complications, limb ischemia, stroke, and acute kidney injury were reported with varying frequency of 1-6%. In conclusion, VA-ECMO is used infrequently for hemodynamic support for VT ablation. Further data on patient selection, procedural optimization, and clinical outcomes are needed to evaluate the efficacy of this strategy.
Gate-geometry dependence of electrical characteristics of p-GaN gate HEMTs (2022)

In this Letter, we experimentally investigate the impact of gate geometry on forward operation of Schottky-gate p-GaN high electron mobility transistors (HEMTs). In particular, we analyze devices with changing gate-metal/p-GaN junction area and p-GaN/AlGaN/GaN heterostructure area in the linear regime. These devices exhibit unique threshold voltage and subthreshold swing scaling dependence with gate geometry that is in contrast with classic field-effect transistors. On the other hand, peak transconductance and ON resistance are found to scale classically. We find that these results arise from the fact that with a Schottky contact to the p-GaN layer, under steady-state conditions, the p-GaN layer voltage is set by current continuity across the gate stack. Furthermore, a detailed scaling study of the gate current reveals that current flow across the p-GaN/AlGaN/GaN heterostructure is not uniform—instead, it preferentially flows through the ungated portion of the p-GaN layer. Our study concludes that in Schottky-type p-GaN gate HEMTs, the respective areas of two junctions constitute an additional design degree of freedom to fine-tune device performance.
Localisation d'un robot mobile par coopération entre vision monoculaire et télémétrie laser (1999)

Les travaux presentes dans ce memoire portent sur l'etude et la mise au point d'une methode de localisation absolue pour robot mobile autonome evoluant dans un environnement de type interieur dynamique. Cette methode est basee sur l'exploitation de la complementarite des informations delivrees par un systeme de perception mixte forme d'un telemetre laser 2D et d'un capteur de vision monoculaire. Notre contribution se situe essentiellement sur le plan methodologique avec notamment : la mise au point d'une strategie de perception active, la preposition d'une technique robuste de segmentation, la recherche de techniques decisionnelles utilisant une approche de type fusion de primitives, l'etude d'une technique d'identification d'amers environnementaux (de type arete verticale) et enfin la mise au point d'une procedure de localisation. La phase d'identification des amers, necessaire a la localisation du robot, necessite le recours a une procedure d'appariements entre aretes segmentees et amers de reference. Une transformation invariante en translation et en rotation, appliquee sur l'ensemble des primitives, conduit a une simplification notable de cette procedure. L'identification consiste alors a realiser une mise en correspondance entre triplets d'amers et triplets d'aretes sur la base de 12 descripteurs invariants, puis entre amers et aretes observees a partir des hypotheses formees. La localisation absolue du mobile est obtenue en definissant l'ensemble des positions compatibles avec les amers observes et delimitee par un polygone d'incertitude.
Dynamic lot sizing models with bounded inventory and backlogging (2005)

This paper addresses a real life single item dynamic lot sizing problem arising in a refinery for crude oil procurement. It can be considered as a lot-sizing problem with bounded inventory and backlogging. The production capacity can be considered to be unlimited and the production cost functions are assumed to be linear but time-varying. The results can be easily extended to concave piecewise linear production cost functions. The goal is to minimize the total costs of production, inventory holding and backlogging. We show that the problem can be solved in O(T2) time with general concave inventory holding and backlogging cost functions where T is the number of periods in the planning horizon. We show that the complexity is reduced to O(T) when the inventory holding cost functions are linear and have some required properties.
Exact travelling wave solutions of non-linear reaction-convection-diffusion equations—An Abel equation based approach (2015)

We consider quasi-stationary (travelling wave type) solutions to a general nonlinear reaction-convection-diffusion equation with arbitrary, autonomous coefficients. The second order nonlinear equation describing one dimensional travelling waves can be reduced to a first kind first order Abel equation. By using two integrability conditions for the Abel equation (the Chiellini lemma and the Lemke transformation), several classes of exact travelling wave solutions of the general reaction–convection-diffusion equation are obtained, corresponding to different functional relations imposed between the diffusion, convection and reaction functions. In particular, we obtain travelling wave solutions for two non-linear second order partial differential equations, representing generalizations of the standard diffusion equation and of the classical Fisher–Kolmogorov equation, to which they reduce for some limiting values of the model parameters. The models correspond to some specific, power law type choices of the reaction and convection functions, respectively. The travelling wave solutions of these two classes of differential equation are investigated in detail by using both numerical and semi-analytical methods.
CO-tolerant operation of platinum-loaded PEM fuel cells (2007)

Biomass is a green energy source, which can be converted to hydrogen rich gas. If this gas is used as feedstock for a PEM fuel cell, it is possible to convert biomass to electricity in an environmental friendly way. A disadvantage of a PEM fuel cell is that platinum, which is used as catalyst to speed up the anode reaction, is a good adsorbent for CO. Carbon monoxide will adhere to the platinum surface blocking the catalyst for hydrogen oxidation. In order to clean the catalyst, oxygen can be added to the fuel stream. By applying negative voltage pulses to the cell terminals, existing water can get electrolyzed. This results in trace amounts of oxygen in the anode channel. Measurements performed on a poisoned fuel cell stack have been conducted. The results of the measurements show that the poisoned cells regenerate after a negative pulse. By optimizing the pulse amplitude, repetition time and duty cycle, the fuel cell used is CO-tolerant for gasses containing 50 ppm CO. Furthermore, cell oscillations, probably related to self-oxidation of carbon monoxide, are observed, which is remarkable for PEM fuel cells with pure platinum loaded catalysts.
Asymmetry of CNOT gate operation in superconducting transmon quantum processors using cross-resonance entangling (2020)

Controlled-NOT (CNOT) gates are commonly included in the standard gate set of quantum processors and provide an important way to entangle qubits. For fixed-frequency qubits using the cross-resonance entangling technique, using the higher-frequency qubit to control the lower-frequency qubit enables much shorter entangling times than using the lower-frequency qubit as the control. Consequently, when implementing a CNOT gate where logical control by the lower-frequency qubit is needed, compilers may implement this functionality by using an equivalent circuit such as placing Hadamard gates on both qubits before and after a CNOT gate controlled by the higher-frequency qubit. However, since the implementation is different depending on which qubit is the control, a natural question arises regarding the relative performance of the implementations. We have explored this using quantum processors on the IBM Q network. The basic circuit used consisted of operations to create a Bell State, followed by the inverse operations so as to return the qubits to their initial state in the absence of errors (Hadamard + CNOT + barrier + CNOT + Hadamard). The circuit depth was varied using multiples of this basic circuit. An asymmetry in the error of the final state was observed that increased with the circuit depth. The strength and direction of the asymmetry was unique but repeatable for each pair of coupled qubits tested. This observation suggests that the asymmetry in CNOT implementation should be characterized for the qubits of interest and incorporated into circuit transpilation to obtain the best accuracy for a particular computation.
ZnO coated nanospring-based chemiresistors (2012)

Chemiresistors were constructed using 3-D silica nanospring mats coated with a contiguous film of ZnO nanocrystals. Chemiresistors with an average ZnO nanocrystal radius &amp;lt;3 nm, or &amp;gt;20 nm, were found to exhibit a relative change in conductance of a factor of 50 upon exposure to a gas flow of 20% O2 and 80% N2 with ∼500 ppm of toluene and an operational temperature of 400 °C. Samples with an average ZnO nanocrystal radius of 15 nm were found to be the most responsive with a relative conductance change of a factor of 1000. The addition of metal nanoparticles (average radius equal to 2.4 nm) onto the surface of the ZnO nanocrystals (average radius equal to 15 nm) produced a relative change in conductance of a factor of 1500. For the optimum conditions (T = 400 °C, grain size ∼15 nm) well-defined spikes in conductance to explosive vapors (TNT, TATP) were obtained for 0.1 ms exposure time at ppb levels.
Model-Based Design of Runtime Adaptation Strategies (2008)

Designing and implementing embedded computing systems is more challenging than non-embedded systems because of the need to interact closely with a changeable physical universe that operates in real time, and because of the extra constraints imposed by the packaging and environmental concerns for many embedded systems. In addition, the challenges posed by distributed systems architectures and composite implementations of stand-alone components (which are already prevalent in non-embedded environments) have begun to become commonplace consequences of the requirements for new embedded solutions. There are especially challenging issues surrounding the design and implementation of distributed embedded systems with managed quality of service (QoS) properties when those systems must adapt to the changes in both the computational and physical universes within which these systems must operate. To date, research has concentrated on constructing runtime system abstractions and mechanisms that can adaptively meet the design requirements. However, using these abstractions and mechanisms requires highly skilled individuals with strong intuitions about both the needs of the domain and the ways to manipulate the various dimensions contributing to the managed QoS behavior. There are few design paradigms to guide the design or construction of this sort of dynamic, adaptive, managed runtime behavior. There is a compelling need for applying design-time methodologies to develop and control these runtime adaptations
Magnetic resonance imaging of the brain with gadopentetate dimeglumine‐DTPA: Comparison of T1‐weighted spin‐echo and 3D gradient‐echo sequences (1996)

Short TR, short TE, high resolution, 3D gradient-recalled echo (GRE) imaging was evaluated for lesion detection in the brain. High resolution 3D GRE data acquisition was used to reduce partial volume effects and flow artifacts, to better visualize smaller structures, to minimize signal losses caused by field inhomogeneities, and to allow better image reformatting. Spin-echo (SE) and 3D GRE approaches were compared for lesion detection after the administration of an MR contrast agent, gadopentetate dimeglumine. Preliminary clinical studies demonstrated that the signal-to-noise ratio (SNR) in each slice of the GRE scan was worse than that of the SE scan because of the much thicker slices acquired with the SE technique. However, by averaging two adjacent 3D slices, the SNR of the two methods was essentially equivalent. In the averaged GRE slices, large lesions were seen just as well as in the SE images. More importantly, small lesions were better visualized in the thin 3D GRE images than in the thick SE images for the lesions studied in this work and the protocols used. These observations were confirmed by theoretical simulations.