gebhart/patrepeval huggingface dataset:
Just Noticeable Differences in Visual Attributes (2015)

We explore the problem of predicting "just noticeable differences" in a visual attribute. While some pairs of images have a clear ordering for an attribute (e.g., A is more sporty than B), for others the difference may be indistinguishable to human observers. However, existing relative attribute models are unequipped to infer partial orders on novel data. Attempting to map relative attribute ranks to equality predictions is non-trivial, particularly since the span of indistinguishable pairs in attribute space may vary in different parts of the feature space. We develop a Bayesian local learning strategy to infer when images are indistinguishable for a given attribute. On the UT-Zap50K shoes and LFW-10 faces datasets, we outperform a variety of alternative methods. In addition, we show the practical impact on fine-grained visual search.
Direct synthesis of fused 1,2,3,4,5-pentathiepins (2005)

Treatment of nucleophilic heterocycles like pyrroles and thiophenes, and their tetrahydro derivatives, with S2Cl2 and DABCO in chloroform at room temperature provides a simple one-pot synthesis of fused mono and bispentathiepins. N-Methylpyrrole and its 2-chloro and 2,5-dichloro derivatives and N-methylpyrrolidine all give the same dichloropentathiepin 1a. N-Ethyl, isopropyl and tert-butylpyrrolidine behave similarly; the isopropylpyrrolidine also gives the bispentathiepin 6which undergoes an intriguing rearrangement to the symmetrical monopentathiepin 1c. N-Methyl and ethyl indole give either 2,3-dichloro derivatives 8 or the pentathiepinoindoles 9, depending upon the reaction conditions. Thiophene and tetrahydrothiophene give the pentathiepin 10. X-Ray crystal structures are provided for the pentathiepins 1a and 1d, and possible reaction pathways are suggested for the extensive cascade reactions reported.
Tunneling currents in electron transfer reaction in proteins. II. Calculation of electronic superexchange matrix element and tunneling currents using nonorthogonal basis sets (1996)

In this paper we further develop the concept of interatomic tunneling currents [A.A. Stuchebrukhov, J. Chem. Phys. 104, 8424 (1996)] for the description of long-range electron tunneling in proteins. Here we discuss a formulation of the theory for the case when nonorthogonality of the atomic basis set of the medium propagating electron is explicitly taken into account. This method provides an effective computational scheme for an exact, i.e., nonperturbative, evaluation (in one-electron approximation) of the superexchange electron tunneling matrix element, and allows one to determine which regions in the protein matrix are important for the tunneling process. The theory is applied for calculation of tunneling currents and the electronic matrix element in His126-Ru-modified blue copper protein azurin from a recent experimental work of Gray and co-workers. Analysis of interatomic currents reveals a nontrivial structure of the tunneling flow between donor and acceptor in the intervening protein medium in this system.
Magnesium levels after magnesium-containing cathartics (1988)

To determine the effect on serum Mg++ levels of oral Magnesium-containing cathartics (MgCC) used in the treatment of suspected drug overdose, a prospective, non-randomized study of 24 cases of suspected drug overdose was conducted. Ten cases admitted to the observation unit were assigned to the single dose MgCC group. Fourteen cases admitted to either the ICU or the observation unit were assigned to the multiple dose MgCC group. Single dose cases received 30 gm of magnesium sulfate (MgSO4) at 0 hours. Multiple dose cases received 3 30 gm doses of MgSO4 at 0, 4, and 8 hours. Mg++ levels were measured prior to each MgSO4 dose and 1 and 4 hours after the final dose in both groups. In the single dose group, there was no difference between baseline Mg++ levels and post MgSO4 levels, and only 2/10 developed slightly elevated levels (2.2, 2.3 mEq/L). In the multiple dose group, levels increased and remained significantly higher than baseline after the second MgSO4 dose, and 9/14 developed elevated levels (2.2 to 5.0 mEq/L). All patients who developed elevated Mg++ levels had normal BUN and creatinine values. When the single and multiple dose groups were compared, baseline Mg++ levels were no different (1.68 +/- 0.21 vs 1.69 +/- 0.24, p = 0.952), but peak Mg++ levels were significantly higher in the multiple dose group (1.80 +/- 0.31 vs 2.61 +/- 0.86, p = 0.004). Cases that developed hypermagnesemia had slightly higher baseline Mg++ levels (1.78 +/- 0.22 vs 1.60 +/- 0.19 mEq/L, p = 0.041). In the multiple dose group, higher peak Mg++ levels were noted in cases involving ingestions of anticholinergic or opioid drugs (2.83 vs 1.98, p = 0.025). Hypermagnesemia developed in some cases with normal renal function, blood pressure, and urine output. We conclude that significant hypermagnesemia can occur rapidly after use of multiple dose Mg++ cathartics in standard doses in patients with normal renal function.
Designing LP Turbines for Optimized Airfoil Lift (2008)

In the last 10 to 15 years substantial effort has been spent on increasing the airfoil lift especially in aero engine low pressure turbines. This has been attractive, since increased airfoil lift can be used for airfoil count decrease leading to weight and hardware cost reduction. The challenge with this effort consequently has been to keep the efficiency at high levels. Depending on the baseline level of airfoil lift, an increase of 20% to 50% has been realized and at least partly incorporated in modern turbine designs. With respect to efficiency there is actually an optimum level of airfoil lift. Airfoil rows at a lift level below this optimum suffer from an excessive number of airfoils with too much wetted surface and especially increasing trailing edge losses. Airfoils at lift levels above this optimum suffer from growing losses due to high peak Mach numbers inside the airfoil row, higher rear diffusion on the airfoil suction sides and increasing secondary flow losses. Since fuel cost have been rising significantly as has been the awareness of the environmental impact of CO2, it becomes more and more important to design LP turbines for an optimal trade between efficiency and weight to achieve the lowest engine fuel burn. This paper summarizes work done recently and in the past to address the main influences and mechanisms of the airfoil lift level with respect to losses and efficiency as a basis for determination of optimal airfoil lift selection.
Faculty Opinions recommendation of Quantitative imaging of nitrogen fixation by individual bacteria within animal cells. (2007)

Biological nitrogen fixation, the conversion of atmospheric nitrogen to ammonia for biosynthesis, is exclusively performed by a few bacteria and archaea. Despite the essential importance of biological nitrogen fixation, it has been impossible to quantify the incorporation of nitrogen by individual bacteria or to map the fate of fixed nitrogen in host cells. In this study, with multi-isotope imaging mass spectrometry we directly imaged and measured nitrogen fixation by individual bacteria within eukaryotic host cells and demonstrated that fixed nitrogen is used for host metabolism. This approach introduces a powerful way to study microbes and global nutrient cycles. PMID: 17872448 Funding information This work was supported by: NIBIB NIH HHS, United States Grant ID: P41 EB001974
Sound-space symbolism: Associating articulatory front and back positions of the tongue with the spatial concepts of forward/front and backward/back (2023)

The study investigated whether the concepts of forward/front and backward/back are associated with the vocalizations requiring the front/back position of the tongue. In Experiment 1, the participants were visually presented with a forward or backward-directed movement. They were asked to vocalize the front ([i]) or back ([o]) vowel based on whether the stimulus moved forwards or backwards. Vocal responses were produced faster when the required response was hypothetically congruent with the movement direction (e.g., [i] – forward-directed movement) in comparison to incongruent conditions. In Experiment 2, the same effect was observed when these vocal responses were performed based on whether the target object was at the front of or back of the reference object. These observations present a novel sound-space symbolism phenomenon, which associates spatial concepts of forward/front and backward/back with particular speech sounds. We propose that this finding might contribute to an understanding of cognitive mechanisms in sound–space associations and more generally in sound symbolism.
The effect of calmodulin on the phosphoprotein intermediate of Mg2+-dependent Ca2+-stimulated adenosine triphosphatase in human erythrocyte membranes (1981)

The effect of calmodulin on the formation and decomposition of the Ca2+-dependent phosphoprotein intermediate of the (Mg2+ + Ca2+)-dependent ATPase in erythrocyte membranes was investigated. In the presence of 60 microM-Ca2+ and 25 microM-MgCl2, calmodulin (0.5-1.5 microgram) did not alter the steady-state concentration of the phosphoprotein, but increased its rate of decomposition. Higher calmodulin concentrations significantly decreased the steady-state concentration of phosphoprotein. Calmodulin (0.5-1.7 microgram) increased Ca2+-transport ATPase activity by increasing the turnover rate of its phosphoprotein intermediate. Increasing the MgCl2 concentration from 25 microM to 250 microM increased the (Mg2+ + Ca2+)-dependent ATPase activity, but decreased the concentration of the phosphoprotein intermediate. Similarly to calmodulin, MgCl2 increased the turnover rate of the Ca2+-transport ATPase complex (about 3-fold). At the higher MgCl2 concentration calmodulin did not further affect the decomposition of the phosphoprotein intermediate. It was concluded that both calmodulin and MgCl2 increase the turnover of the Ca2+-pump by enhancing the decomposition of the Ca2+-dependent phosphoprotein intermediate.
The Commensal Microbe V eillonella as a Marker for Response to an FGF19 Analog in NASH (2020)

Veillonella may be a bile acid-sensitive bacteria whose enrichment is enabled by aldafermin-mediated suppression of bile acid synthesis and, in particular, decreases in toxic bile acids. This study provides an integrated analysis of gut microbiome, serum bile acid metabolome, imaging, and histological measurements in clinical trials testing aldafermin for NASH. Our results provide a better understanding of the intricacies of microbiome-host interactions (clinicaltrials.gov trial No. NCT02443116).
On the Estimation of a Univariate Gaussian Distribution: A Comparative Approach (2015)

Estimation of the unknown mean, μ and variance, σ2 of a univariate Gaussian distribution given a single study variable x is considered. We propose an approach that does not require initialization of the sufficient unknown distribution parameters. The approach is motivated by linearizing the Gaussian distribution through differential techniques, and estimating, μ and σ2 as regression coefficients using the ordinary least squares method. Two simulated datasets on hereditary traits and morphometric analysis of housefly strains are used to evaluate the proposed method (PM), the maximum likelihood estimation (MLE), and the method of moments (MM). The methods are evaluated by re-estimating the required Gaussian parameters on both large and small samples. The root mean squared error (RMSE), mean error (ME), and the standard deviation (SD) are used to assess the accuracy of the PM and MLE; confidence intervals (CIs) are also constructed for the ME estimate. The PM compares well with both the MLE and MM approaches as they all produce estimates whose errors have good asymptotic properties, also small CIs are observed for the ME using the PM and MLE. The PM can be used symbiotically with the MLE to provide initial approximations at the expectation maximization step.
Helping You Protect You (2014)

Guest editors M. Angela Sasse and Charles C. Palmer speak with security practitioners about what companies are doing to keep customers secure, and what users can do to stay safe.
Caching in HTTP Adaptive Streaming (2014)

Video streaming is a major source of Internet traffic today and usage continues to grow at a rapid rate. To cope with this new and massive source of traffic, ISPs use methods such as caching to reduce the amount of traffic traversing their networks and serve customers better. However, the presence of a standard cache server in the video transfer path may result in bitrate oscillations and sudden rate changes for Dynamic Adaptive Streaming over HTTP (DASH) clients. In this paper, we investigate the interactions between a client and a cache that result in these problems, and propose an approach to solve it. By adaptively controlling the rate at which the client downloads video segments from the cache, we can ensure that clients will get smooth video. We verify our results using simulation and show that compared to a standard cache our approach (1) can reduce bitrate oscillations (2) prevents sudden rate changes, and compared to a no-cache scenario (3) provides traffic savings, and (4) improves the quality of experience of clients.
ChemInform Abstract: THE SINTERING OF SUPPORTED METAL CATALYSTS. II. COMPARISON OF SINTERING RATES S OF SUPPORTED PLATINUM, IRIDIUM, AND RHODIUM CATALYSTS IN HYDROGEN AND OXYGEN (1978)

Abstract Die in reduzierenden (H7) und oxidierenden (O 2) Atmosphären in Abhängigkeit von der Temp. (250‐800°C) an Pt‐, Ir‐ und Rh‐Trägerkatalysatoren (A1203) auftretenden Änderungen der Dispersion werden untersucht.
Clinical potential of photodynamic diagnosis and therapy of tracheobronchial malignancies in the visible and infrared spectral ranges (2020)

Abstract This article describes a video endoscopy system intended for fluorescence‐based imaging of the tracheobronchial tree in the visible (VIS) and near‐infrared (NIR) regions of the spectrum. This system helps acquire both fluorescence images (VIS/NIR) and a white‐light image of the same area and has been developed on the basis of a standard bronchofiberscope with several diode lasers used as the light sources to excite Vis and NIR, the white‐light source, and photodynamic irradiation. A multimodal video system forms images and gives the possibility to perform targeted photodynamic therapy and control the dose of light irradiation through assessing the degree of photobleaching.The system capability is illustrated through clinical examples. The paper describes the procedure for photodynamic theranostics with chlorin e6 in patients with central lung cancer. The possibility of additional accurate localization of tumor lesions and their borders with NIR imaging is shown; to acquire a NIR image, a common dose of indocyanine green (ICG) used in angiography was administered to patients during the examination. It is also demonstrated that the same lesions can be identified using a combination of two dyes: chlorin e6 + ICG.
Complexity analysis in holographic 3D video generation (2012)

Realizing the very natural video by using holography technology is thought as the ultimate goal of 3D display, and it is still remained as the Holy Grail to be explored. Difficulties lie on two challenging issues: development of the Giga-pixel holographic video display which is feasible and meaningful for commercialization and fast calculation algorithms for the real-time holographic video generation. This presentation reviews the current status in holographic video generation methods in the aspect of the latter issue. The recent algorithms can be categorized into two main concepts of the point source hologram and the Fourier transform hologram. By analyzing the complexity of the algorithms, we realized that there is a common limitation regardless of the type of algorithms. I will address this issue and discuss the research directions to move one step forward for the commercial holographic video displays.
Mechanisms of Veno‐Occlusion within and outside the Canine Corpus Cavernosum Penis Using a Pressure‐Flow Technique and Cavernoso‐Venography (1996)

Both intrinsic and extrinsic venous occlusion mechanisms exist and that the former is activated primarily by unilateral stimulation of the pelvic nerve and the latter by bilateral stimulation of the pudendal nerve. The occlusion site for the extrinsic mechanism was localized to where the dorsal vein penetrates the muscles at the base of the pelvis, whereas the precise site for the intrinsic mechanism could not be determined.
Targeting of Ubiquitin E3 Ligase RNF5 as a Novel Therapeutic Strategy in Neuroectodermal Tumors (2022)

RNF5, an endoplasmic reticulum (ER) E3 ubiquitin ligase, participates to the ER-associated protein degradation guaranteeing the protein homeostasis. Depending on tumor model tested, RNF5 exerts pro- or anti-tumor activity. The aim of this study was to elucidate the controversial role of RNF5 in neuroblastoma and melanoma, two neuroectodermal tumors of infancy and adulthood, respectively. RNF5 gene levels are evaluated in publicly available datasets reporting the gene expression profile of melanoma and neuroblastoma primary tumors at diagnosis. The therapeutic effect of Analog-1, an RNF5 pharmacological activator, was investigated on in vitro and in vivo neuroblastoma and melanoma models. In both neuroblastoma and melanoma patients the high expression of RNF5 correlated with a better prognostic outcome. Treatment of neuroblastoma and melanoma cell lines with Analog-1 reduced cell viability by impairing the glutamine availability and energy metabolism through inhibition of F<sub>1</sub>F<sub>o</sub> ATP-synthase activity. This latter event led to a marked increase in oxidative stress, which, in turn, caused cell death. Similarly, neuroblastoma- and melanoma-bearing mice treated with Analog-1 showed a significant delay of tumor growth in comparison to those treated with vehicle only. These findings validate RNF5 as an innovative drug target and support the development of Analog-1 in early phase clinical trials for neuroblastoma and melanoma patients.
Surface-active ionic liquids for palladium-catalysed cross coupling in water: effect of ionic liquid concentration on the catalytically active species (2017)

We report the design and synthesis of surface-active ionic liquids for application in palladium-catalyzed cross coupling reactions. A series of dodecylimidazolium-based ionic liquids were applied as additives in the Heck reaction of ethyl acrylate and iodobenzene, and high yields of >90% could be obtained in water without the addition of further ligands. Our results indicate that the ionic liquid concentration in water is the key factor affecting the formation of the catalytically active species and hence the yield. Moreover, imidazolium-based ionic liquids that are able to form a carbene species differ significantly from conventional cationic surfactants, as a concentration dependent formation of the N-heterocyclic carbene complex was observed.
Wirklich grüne Synthese von Artemisinin aus Pflanzenextrakt (2018)

Abstract Durch den Einsatz von Pflanzenextrakten als Reaktionsmedium für chemische Synthesen können hocheffiziente und nachhaltige Prozesse erzielt werden. Dieses Prinzip wird auf die Partialsynthese von Artemisinin angewendet, ein sekundärer Metabolit der Pflanze Artemisia annua und eine wichtige Vorstufe von hochwirksamen Malariamedikamenten. Extrakte von A. annua enthalten außer Artemisinin auch als Abfallprodukte angesehene Komponenten, wie Dihydroartemisininsäure, die letzte Vorstufe von Artemisinin in der Biosynthese, und Chlorophyll, das als Photosensibilisator wirkt. Durch intensive Beleuchtung des unaufgearbeiteten Extrakts mit sichtbarem Licht wird Artemisinin in einem kontinuierlichen Durchflussreaktor in hoher Ausbeute aus dem Extrakt erzeugt. Dieser an der Biosynthese angelehnte Prozess ist dabei hocheffizient und nachhaltiger als etablierte Prozesse auf der Basis reiner Substanzen.
ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish (2010)

Arterial morphogenesis is an important and poorly understood process. In particular, the signaling events controlling arterial formation have not been established. We evaluated whether alterations in the balance between ERK1/2 and PI3K signaling pathways could stimulate arterial formation in the setting of defective arterial morphogenesis in mice and zebrafish. Increased ERK1/2 activity in mouse ECs with reduced VEGF responsiveness was achieved in vitro and in vivo by downregulating PI3K activity, suppressing Akt1 but not Akt2 expression, or introducing a constitutively active ERK1/2 construct. Such restoration of ERK1/2 activation was sufficient to restore impaired arterial development and branching morphogenesis in synectin-deficient mice and synectin-knockdown zebrafish. The same approach effectively stimulated arterial growth in adult mice, restoring arteriogenesis in mice lacking synectin and in atherosclerotic mice lacking both LDL-R and ApoB48. We therefore conclude that PI3K-ERK1/2 crosstalk plays a key role in the regulation of arterial growth and that the augmentation of ERK signaling via suppression of the PI3K signaling pathway can effectively stimulate arteriogenesis.
Radiation-induced gastrointestinal (GI) syndrome as a function of age (2023)

Previous studies show increased sensitivity of older mice (28-29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality was associated with higher levels of apoptotic stem cells in small intestinal crypts that correlated with sphingomyelinase activity, a source of pro-apoptotic ceramide. The objective of this study is to determine whether the cycling crypt base columnar cells (CBCs) in aging animals are specifically more sensitive to radiation effects than the CBCs in young adult mice, and to identify factors that contribute to increased radiosensitivity. Mortality induced by subtotal body radiation was assessed at different doses (13 Gy, 14 Gy, and 15 Gy) in young adult mice versus older mice. Each dose was evaluated for the occurrence of lethal GI syndrome. A higher death rate due to radiation-induced GI syndrome was observed in older mice as compared with young adult mice: 30 vs. 0% at 13 Gy, 90 vs. 40% at 14 Gy, and 100 vs. 60% at 15 Gy. Radiation-induced damage to crypts was determined by measuring crypt regeneration (H&E staining, Ki67 expression), CBC biomarkers (lgr5 and ascl2), premature senescence (SA-β-gal activity), and apoptosis of CBCs. At all three doses, crypt microcolony survival assays showed that the older mice had fewer regenerating crypts at 3.5 days post-radiation treatment. Furthermore, in the older animals, baseline CBCs numbers per circumference were significantly decreased, correlating with an elevated apoptotic index. Analysis of tissue damage showed an increased number of senescent CBCs per crypt circumference in older mice relative to younger mice, where the latter was not significantly affected by radiation treatment. It is concluded that enhanced sensitivity to radiation-induced GI syndrome and higher mortality in older mice can be attributed to a decreased capacity to regenerate crypts, presumably due to increased apoptosis and senescence of CBCs.