gebhart/patrepeval huggingface dataset:
Supplementary fig 17 from Changes in Peripheral and Local Tumor Immunity after Neoadjuvant Chemotherapy Reshape Clinical Outcomes in Patients with Breast Cancer (2023)

&lt;p&gt;Supplementary Figure 17: An 8-gene activated T cell signature derived from whole blood at surgery is associated with residual disease burden and recurrence.&lt;/p&gt;
Investigation of Network Heterogeneities in Filled, Trimodal, Highly Functional PDMS Networks by <sup>1</sup>H Multiple Quantum NMR (2007)

The segmental order and dynamics of polymer network chains in a filled, trimodal silicone foam network have been studied by static 1H multiple quantum (MQ) NMR methods to gain insight into the structure property relationships. The foam materials were synthesized with two different types of cross-links, with functionalities, φ, of 4 and near 60. The network chains were composed of distributions of high, low, and medium molecular weight chains. Cross-linking was accomplished by standard acid-catalyzed reactions. MQ NMR methods have detected domains with residual dipolar couplings (〈Ωd〉) of near 4 and 1 krad/s assigned to (a) the shorter polymer chains and chains near the multifunctional (φ = 60) cross-linking sites and to (b) the longer polymer chains far from these sites. Three structural variables were systematically varied and the mechanical properties via compression and distributions of residual dipolar couplings measured in order to gain insight into the network structural motifs that contribute significantly to the composite properties. The partitioning and average values of the residual dipolar couplings for the two domains were observed to be dependent on formulation variables and provided increased insight into the network structure of these materials which are unavailable from swelling and spin-echo methods. The results of this study suggest that the domains with high cross-link density contribute significantly to the high strain modulus, while the low cross-link density domains do not. This is in agreement with theories and experimental studies on silicone bimodal networks over the last 20 years. In situ MQ-NMR of swollen samples suggests that the networks deform heterogeneously and nonaffinely. The heterogeneity of the deformation process was observed to depend on the amount of the high functionality cross-linking site PMHS. The NMR experiments shown here provide increased ability to characterize multimodal networks of typical engineering silicone foam materials and to gain significant insight into structure−property relationships.
Low-Frequency Noise Reduction in 22FDX®: Impact of Device Geometry and Back Bias (2019)

The impact of device geometry, process integration and back bias on Low-Frequency Noise (LFN) performance of 22FDX <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">®</sup> thin oxide devices has been investigated. Calibrated TCAD simulations were used to clarify the role of carrier distribution on LFN. More than 20% (30%) gate bias power spectrum density S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">Vg</sub> reduction is demonstrated in thin (thick) oxide devices with an appropriate choice of device construction and bias.
New 7‐membered diazepanone alkoxyamines for nitroxide‐mediated radical polymerization (2004)

Abstract The synthesis of new 7‐membered diazepanone alkoxyamines [2,2,7,7‐tetramethyl‐1‐(1‐phenyl‐ethoxy)‐[1,4]diazepan‐5‐one ( 3 ) and 2,7‐diethyl‐2,3,7‐trimethyl‐1‐(1‐phenyl‐ethoxy)‐[1,4]diazepan‐5‐one ( 8 )] through the Beckmann rearrangement of piperidin‐4‐one alkoxyamines was developed. Both 3 and 8 were evaluated as initiators and regulators for the nitroxide‐mediated radical polymerization of styrene and n ‐butyl acrylate. 8 , a sterically highly hindered alkoxyamine readily available as a crystalline solid, allowed the fast and controlled polymerization and preparation of polymers with low polydispersity indices (1.2–1.4) up to a degree of polymerization of about 100. © 2004 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 42: 3332–3341, 2004
Treating IgA nephropathy: quid novi? (2014)

IgA nephropathy is a common autoimmune renal disease resulting in kidney failure for patients with significant proteinuria. The therapeutic options are limited including non-specific treatment to reduce proteinuria accomplished by renin-angiotensin blockade. Strategies to control intrarenal inflammation include the administration of fish oil and for severe disease the use of immunosuppressive agents such as cyclophosphamide, glucocorticosteroids, and mycophenolate mofetil. In light of the limited option, there is an unmet need for novel therapeutic intervention in patients with progressive disease. Herein, we review the evidence for existing treatment choices and explore new immunopharmacologic agents being investigated for IgA nephropathy.
Pancreatic Beta Cells in Very Old Mice Retain Capacity for Compensatory Proliferation (2012)

Recent studies suggested that in old mice, beta cells lose their regenerative potential and cannot respond to mitogenic triggers. These studies examined beta cell replication in aged mice under basal conditions and in response to specific stimuli including treatment with the glucagon-like peptide-1 analog exenatide, streptozotocin injection, partial pancreatectomy, and high fat diet. However, it remains possible that the ability to mount a compensatory response of beta cells is retained in old age, but depends on the specific stimulus. Here, we asked whether partial ablation of beta cells in transgenic mice, using doxycycline-inducible expression of diphtheria toxin, triggers a significant compensatory proliferative response in 1-2-year-old animals. Consistent with previous reports, the basal rate of beta cell replication declines dramatically with age, averaging 0.1% in 2-year-old mice. Transient expression of diphtheria toxin in beta cells of old mice resulted in impaired glucose homeostasis and disruption of islet architecture (ratio of beta to alpha cells). Strikingly, the replication rate of surviving beta cells increased 3-fold over basal rate, similarly to the -fold increase in replication rate of beta cells in young transgenic mice. Islet architecture and glucose tolerance slowly normalized, indicating functional significance of compensatory beta cell replication in this setting. Finally, administration of a small molecule glucokinase activator to old mice doubled the frequency of beta cell replication, further showing that old beta cells can respond to the mitogenic trigger of enhanced glycolysis. We conclude that the potential for functionally significant compensatory proliferation of beta cells is retained in old mice, despite a decline in basal replication rate.
Antihepatotoxic actions of Allium sativum bulbs. (1986)

Garlic constituents, the volatile oil, alliin, S-allylmercaptocysteine (ASSC) and S-methylmercapto-cysteine (MSSC) were subjected to assay for their antihepatotoxic activity using the IN VITRO and IN VIVO liver damage models. Marked inhibitory activity was found with the volatile oil, ASSC and MSSC in carbon tetrachloride (CCl 4 )- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes as model systems. ASSC exhibited a remarkable inhibitory action and the volatile oil, alliin and MSSC showed tendencies to elicit protective actions in GalN-produced liver lesion in rats. The volatile oil inhibited CCl 4 -induced free radical formation and lipid peroxidation, indicating that anti-oxidative activity participates in the inhibitory effect of the volatile oil in CCl 4 -evoked liver damage.
An optimization approach for extracting and encoding consistent maps in a shape collection (2012)

We introduce a novel approach for computing high quality point-to-point maps among a collection of related shapes. The proposed approach takes as input a sparse set of imperfect initial maps between pairs of shapes and builds a compact data structure which implicitly encodes an improved set of maps between all pairs of shapes. These maps align well with point correspondences selected from initial maps; they map neighboring points to neighboring points; and they provide cycle-consistency, so that map compositions along cycles approximate the identity map. The proposed approach is motivated by the fact that a complete set of maps between all pairs of shapes that admits nearly perfect cycle-consistency are highly redundant and can be represented by compositions of maps through a single base shape. In general, multiple base shapes are needed to adequately cover a diverse collection. Our algorithm sequentially extracts such a small collection of base shapes and creates correspondences from each of these base shapes to all other shapes. These correspondences are found by global optimization on candidate correspondences obtained by diffusing initial maps. These are then used to create a compact graphical data structure from which globally optimal cycle-consistent maps can be extracted using simple graph algorithms. Experimental results on benchmark datasets show that the proposed approach yields significantly better results than state-of-the-art data-driven shape matching methods.
Microwave-assisted switching of a single perpendicular magnetic tunnel junction nanodot (2015)

We used a magnetic tunnel junction (MTJ) to study the microwave-assisted switching (MAS) of a perpendicular magnetic nanodot. Because the sample structure enables the direct observation of fast magnetization dynamics through MTJ signals, the switching behavior is examined in relation with the induced magnetization excitation. By utilizing the MTJ signals, we observe several ferromagnetic resonance (FMR) modes and identify the lowest FMR mode as the cause of switching field reduction. The switching field decreases as the microwave frequency increases, and this frequency–magnetic field relationship coincides with that of the lowest FMR mode near a critical frequency. We also investigate the size dependence of MAS.
Targeting Bile Acid Receptors: Discovery of a Potent and Selective Farnesoid X Receptor Agonist as a New Lead in the Pharmacological Approach to Liver Diseases (2017)

Bile acid (BA) receptors represent well-defined targets for the development of novel therapeutic approaches to metabolic and inflammatory diseases. In the present study, we report the generation of novel C-3 modified 6-ethylcholane derivatives. The pharmacological characterization and molecular docking studies for the structure-activity rationalization, allowed the identification of 3β-azido-6α-ethyl-7α-hydroxy-5β-cholan-24-oic acid (compound <b>2</b>), a potent and selective FXR agonist with a nanomolar potency in transactivation assay and high efficacy in the recruitment of SRC-1 co-activator peptide in Alfa Screen assay. <i>In vitro</i>, compound <b>2</b> was completely inactive towards common off-targets such as the nuclear receptors PPARα, PPARγ, LXRα, and LXRβ and the membrane G-coupled BA receptor, GPBAR1. This compound when administered <i>in vivo</i> exerts a robust FXR agonistic activity increasing the liver expression of FXR-target genes including <i>SHP, BSEP, OSTα</i>, and <i>FGF21</i>, while represses the expression of CYP7A1 gene that is negatively regulated by FXR. Collectively these effects result in a significant reshaping of BA pool in mouse. In summary, compound <b>2</b> represents a promising candidate for drug development in liver and metabolic disorders.
Suppl. Table 1 from HSP70 Inhibition Limits FAK-Dependent Invasion and Enhances the Response to Melanoma Treatment with BRAF Inhibitors (2023)

&lt;p&gt;Coefficient of interaction (CI) values for PET-16 and targeted therapeutic agent PLX4032 in BRAF V600E melanoma cell lines.&lt;/p&gt;
Designing Minimally Invasive Preocular Contact Tips for Potential Application in Tear Collection (2018)

The PCT proposed in this study can be a promising tool for minimally invasive collection of basal tears from the inferior palpebral conjunctiva.
Efficient embedding to solve the quantum linear systems problem in near-term quantum processors (2022)

Recent advances in quantum machine learning and quantum state embedding are integrated, providing a resource efficient framework for solutions of linear systems on Noisy Intermediate Scale Quantum (NISQ) machines. A divide and conquer algorithm is used to embed the indexing vector after which the Coherent Variational Quantum Linear Solver (CVQLS) algorithm is used to invert the problem matrix. This integrated procedure has an improved complexity scaling in the quantum resources needed to execute and produces solutions which agree with what is found classically.
Trustworthy Wireless Networks: Issues and Applications (Invited Paper) (2010)

Wireless networks are susceptible to various attacks due to their open nature of operations. Existing security mechanisms and systems are rarely robust under attacks, misoperation and internal faults. Most of the solutions are targeted to specific attacks and also works after detecting considerable damage and provides little protection if one or more components are compromised. These approaches are not sufficient for holistic and systemic security. In this paper we analyse a more systematic security approach by exploiting the fundamental relationships among the network components. We explore a concept called trust worthy network where nodes establishes relationships among themselves based on the mutual observations and interactions. These relationships will help to derive the level of security and trust to be possessed on the nodes and the message received from the nodes. We analyse in detail the various issues in constructing the trustworthy networks, impact of various network dynamics on the trust relationships and the applications of trust worthiness in assessing the information quality, to evict the misbehaving nodes and to provide other related security services.
Dual stereoselectivity in the nucleophilic attack on (.pi.-allyl)palladium complexes (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTDual stereoselectivity in the nucleophilic attack on (.pi.-allyl)palladium complexesJan E. Baeckvall, Ruth E. Nordberg, and Didier WilhelmCite this: J. Am. Chem. Soc. 1985, 107, 24, 6892–6898Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/ja00310a025https://doi.org/10.1021/ja00310a025research-articleACS PublicationsRequest reuse permissionsArticle Views609Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Evaluation of Sn<sub>0.9</sub>Fe<sub>0.1</sub>O<sub>2‐<i>δ</i></sub> as Potential Anode Material for Sodium‐Ion Batteries (2023)

Abstract The introduction of transition metals such as iron in oxides of alloying elements as, for instance, SnO 2 has been proven to enable higher capacities and superior charge storage performance when used as lithium‐ion electrode materials. Herein, we report the evaluation of such electrode materials, precisely (carbon‐coated) Sn 0.9 Fe 0.1 O 2− δ (−C), for sodium‐ion battery applications. The comparison with SnO 2 as reference material reveals the beneficial impact of the presence of iron in the tin oxide lattice, enabling higher specific capacities and a greater reversibility of the de‐/sodiation process – just like for lithium‐ion battery applications. The overall achievable capacity, however, remains relatively low with about 300 mAh g −1 and up to more than 400 mAh g −1 for Sn 0.9 Fe 0.1 O 2‐δ and Sn 0.9 Fe 0.1 O 2− δ ‐C, respectively, compared to the theoretical specific capacity of more than 1,300 mAh g −1 when assuming a completely reversible alloying and conversion reaction. The subsequently performed ex situ/operando XRD and ex situ TEM/EDX analysis unveils that this limited capacity results from an incomplete de‐/sodiation reaction, thus, providing valuable insights towards an enhanced understanding of alternative reaction mechanisms for sodium‐ion anode material candidates.
Design optimization of vibration isolation system through minimization of vibration power flow (2008)

A vibration power minimization model is developed, based on the mobility matrix method, for a vibration isolation system consisting of a vibrating source placed on an elastic support structure through multiple resilient mounts. This model is applied to investigate the design optimization of an X-Y motion stage-based vibration isolation system used in semiconductor wire-bonding equipment. By varying the stiffness coefficients of the resilient mounts while constraining the dynamic displacement amplitudes of the X-Y motion stage, the total power flow from the X-Y motion stage (the vibrating source) to the equipment table (the elastic support structure) is minimized at each frequency interval in the concerned frequency range for different stiffnesses of the equipment table. The results show that when the equipment table is relatively flexible, the optimal design based on the proposed vibration power inimization model gives significantly little power flow than that obtained using a conventional vibration force minimization model at some critical frequencies. When the equipment table is rigid enough, both models provide almost the same predictions on the total power flow.
Alternative Educational Futures for a Knowledge Society (2010)

This article offers a critical analysis of recent trends in educational policy with particular reference to their assumptions about the knowledge society. It examines the implications of the analysis for the issue of elitism and the promotion of greater educational equality. The article concludes by offering an alternative approach to educational policy based on a social realist theory of knowledge.
ChemInform Abstract: Asymmetric Synthesis of S‐(+)‐Argentilactone (I) and S‐(‐)‐Goniothalamin (II). (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
The Human Specific CCR1 Antagonist CP-481,715 Inhibits Cell Infiltration and Inflammatory Responses in Human CCR1 Transgenic Mice (2006)

We previously described the in vitro characteristics of the potent and selective CCR1 antagonist, CP-481,715. In addition to being selective for CCR1 vs other chemokine receptors, CP-481,715 is also specific for human CCR1 (hCCR1), preventing its evaluation in classical animal models. To address this, we generated mice whereby murine CCR1 was replaced by hCCR1 (knockin) and used these animals to assess the anti-inflammatory properties of CP-481,715. Cells isolated from hCCR1 knockin mice were shown to express hCCR1 and migrate in response to both murine CCR1 and hCCR1 ligands. Furthermore, this migration is inhibited by CP-481,715 at dose levels comparable to those obtained with human cells. In animal models of cell infiltration, CP-481,715 inhibited CCL3-induced neutrophil infiltration into skin or into an air pouch with an ED50 of 0.2 mg/kg. CP-481,715 did not inhibit cell infiltration in wild-type animals expressing murine CCR1. In a more generalized model of inflammation, delayed-type hypersensitivity, CP-481,715 significantly inhibited footpad swelling and decreased the amount of IFN-gamma and IL-2 produced by isolated spleen cells from sensitized animals. It did not, however, induce tolerance to a subsequent challenge. These studies illustrate the utility of hCCR1 knockin animals to assess the activity of human specific CCR1 antagonists; demonstrate the ability of the CCR1 antagonist CP-481,715 to inhibit cell infiltration, inflammation, and Th1 cytokine responses in these animals; and suggest that CP-481,715 may be useful to modulate inflammatory responses in human disease.
Effect of Pressure on Discharge Initiation and Chemical Reaction in a Liquid-Phase Electrical Discharge Reactor (2009)

The effect of pressure on liquid-phase electrical discharges was investigated by using a stainless steel high-pressure reactor combined with a high-voltage pulse forming network. The initiation breakdown voltage was obtained under various pressures up to 1380 kPa (200 lb/in <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ). The discharge characteristics including current and voltage waveforms as well as power per pulse were determined. The effect of pressure on streamer chemical reactions was also investigated by measuring the formation rate of hydrogen peroxide (H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> O <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> ) in the solution. Experimental results showed that the initiation voltage is linearly dependent on pressure. The initiation voltage and power were correlated to the increase of heat requirement to vaporize liquid water with increasing pressure. On the other hand, when the input voltage exceeds the initiation voltage such that a stable discharge can be formed, the discharge characteristics are not affected by pressure. Hydrogen peroxide generation was also not affected by external pressure for conditions with stable discharge. To explain the aforementioned results, the bubble theory of liquid-phase breakdown initiation is discussed.