gebhart/patrepeval huggingface dataset:
Recent insights into cerebral cavernous malformations: animal models of CCM and the human phenotype (2010)

Cerebral cavernous malformations are common vascular lesions of the central nervous system that predispose to seizures, focal neurologic deficits and potentially fatal hemorrhagic stroke. Human genetic studies have identified three genes associated with the disease and biochemical studies of these proteins have identified interaction partners and possible signaling pathways. A variety of animal models of CCM have been described to help translate the cellular and biochemical insights into a better understanding of disease mechanism. In this minireview, we discuss the contributions of animal models to our growing understanding of the biology of cavernous malformations, including the elucidation of the cellular context of CCM protein actions and the in vivo confirmation of abnormal endothelial cell-cell interactions. Challenges and progress towards developing a faithful model of CCM biology are reviewed.
ChemInform Abstract: Photoinduced Double Addition of Acetylene to 3‐Oxocyclopent‐1‐ene‐1‐carbonitrile or 3‐Oxocyclopent‐1‐enyl Acetate Leading to 2,3‐Dihydro‐1H‐inden‐1‐one and Other Rearranged Products. (1989)

Abstract UV irradiation of the nitrile (I) produces indanone (III) as the only isolable compound besides tars whereas a variety of products (III)‐(VI), (VIII)‐(Xc) are obtained from the acetate (VII) as substrate.
5-Nitro-3-(2-(4-phenylthiazol-2-yl)hydrazineylidene)indolin-2-one derivatives inhibit HIV-1 replication by a multitarget mechanism of action (2023)

In the effort to identify and develop new HIV-1 inhibitors endowed with innovative mechanisms, we focused our attention on the possibility to target more than one viral encoded enzymatic function with a single molecule. In this respect, we have previously identified by virtual screening a new indolinone-based scaffold for dual allosteric inhibitors targeting both reverse transcriptase-associated functions: polymerase and RNase H. Pursuing with the structural optimization of these dual inhibitors, we synthesized a series of 35 new 3-[2-(4-aryl-1,3-thiazol-2-ylidene)hydrazin-1-ylidene]1-indol-2-one and 3-[3-methyl-4-arylthiazol-2-ylidene)hydrazine-1-ylidene)indolin-2-one derivatives, which maintain their dual inhibitory activity in the low micromolar range. Interestingly, compounds 1a, 3a, 10a, and 9b are able to block HIV-1 replication with EC<sub>50</sub> < 20 µM. Mechanism of action studies showed that such compounds could block HIV-1 integrase. In particular, compound 10a is the most promising for further multitarget compound development.
Assessment of Inhaled Treprostinil Palmitil, Inhaled and Intravenous Treprostinil, and Oral Selexipag in a Sugen/Hypoxia Rat Model of Pulmonary Arterial Hypertension (2022)

Treprostinil palmitil (TP), a long-acting inhaled pulmonary vasodilator prodrug of treprostinil (TRE), has beneficial effects in a Sugen5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension (PAH) that compare favorably to the oral phosphodiesterase 5 inhibitor (PDE<sub>5</sub>) sildenafil. In this study in male Sprague-Dawley rats, a dry powder formulation of TP (TPIP) was compared with inhaled and intravenous TRE and oral selexipag to evaluate inhibition of hemodynamic and pathologic changes in the lungs and heart induced by Su/Hx challenge. Su (20 mg/kg) was injected subcutaneously followed by 3 weeks of Hx (10% O<sub>2</sub>/balance N<sub>2</sub>) and then initiation of test article administration over 5 weeks with room air breathing. Hemodynamics and histopathology were measured at the end of the study. Su/Hx challenge approximately doubled the mean pulmonary arterial blood pressure (mPAP) and the Fulton index, decreased cardiac output (CO), doubled the wall thickness and muscularization of the small (10-50 <i>μ</i>m) and medium (51-100 <i>μ</i>m) sized pulmonary arteries, and increased the percentage of obliterated pulmonary blood vessels. Even though inhaled TRE (65 <i>μ</i>g/kg, 4× daily), intravenous TRE (810 ng/kg/min), and oral selexipag (30 mg/kg, twice daily) provided some beneficial effects against the Su/Hx challenge, the overall benefit was generally greater with TPIP at high dose (117 <i>μ</i>g/kg, once daily). These results demonstrate that TPIP compares favorably to inhaled and intravenous TRE and oral selexipag with respect to inhibition of the pathophysiological changes induced by Su/Hx challenge in rats. SIGNIFICANCE STATEMENT: Treprostinil palmitil (TP) is a long-acting pulmonary vasodilator prodrug of treprostinil (TRE) formulated for inhaled administration by dry powder [treprostinil palmitil inhalation powder (TPIP)]. Comparison of the activity of TPIP, inhaled and intravenous TRE, and oral selexipag in a Sugen5416/hypoxia (Su/Hx) rat model of pulmonary arterial hypertension demonstrated that each of these drugs exert protection against the hemodynamic and histopathological changes induced by the Su/Hx challenge, with the greatest effect on these changes produced by TPIP.
Neutrophils scan for activated platelets to initiate inflammation (2014)

Immune and inflammatory responses require leukocytes to migrate within and through the vasculature, a process that is facilitated by their capacity to switch to a polarized morphology with an asymmetric distribution of receptors. We report that neutrophil polarization within activated venules served to organize a protruding domain that engaged activated platelets present in the bloodstream. The selectin ligand PSGL-1 transduced signals emanating from these interactions, resulting in the redistribution of receptors that drive neutrophil migration. Consequently, neutrophils unable to polarize or to transduce signals through PSGL-1 displayed aberrant crawling, and blockade of this domain protected mice against thromboinflammatory injury. These results reveal that recruited neutrophils scan for activated platelets, and they suggest that the neutrophils' bipolarity allows the integration of signals present at both the endothelium and the circulation before inflammation proceeds.
Novel Polymer Nanocomposites from Templated Mesostructured Inorganic Materials (2003)

ADVERTISEMENT RETURN TO ISSUEPREVCommunication to the...Communication to the EditorNEXTNovel Polymer Nanocomposites from Templated Mesostructured Inorganic MaterialsChristophe Danumah, Mosto Bousmina, and Serge KaliaguineView Author Information Department of Chemical Engineering, Laval University, Ste-Foy, Québec G1K 7P4, Canada; Canada Research Chair on Polymer Physics and Nanomaterials (CRASP), Laval University, Ste-Foy, Québec G1K 7P4, Canada; and NSERC Research Chair on Industrial Nanomaterials, Laval University, Ste-Foy, Québec G1K 7P4, Canada Cite this: Macromolecules 2003, 36, 22, 8208–8209Publication Date (Web):October 8, 2003Publication History Received14 April 2003Published online8 October 2003Published inissue 1 November 2003https://pubs.acs.org/doi/10.1021/ma030217ohttps://doi.org/10.1021/ma030217orapid-communicationACS PublicationsCopyright © 2003 American Chemical SocietyRequest reuse permissionsArticle Views238Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Chemical structure,Layers,Nanocomposites,Nanoparticles,Surfactants Get e-Alerts
LTE modem power consumption, SAR and RF signal strength emulation (2012)

This paper presents a new methodology for emulating the LTE modem power consumption, emitted SAR and RF signal strength when transmitting an LTE signal. The inputs of the methodology are: modem logical/protocol commands, time advance, near-field specifier, and antenna characteristics. The power emulation model(s) are computed by a two layer 4×5×1 neural network based on physical power measurements. SAR is emulated by polynomial interpolation models based on FDTD simulations. The accuracies of the mathematical function approximations for the emulation models of power and SAR are 5.19% and 3.6% respectively. The RF signal strength is emulated by an analytical model.
Engineering Perfect Light Absorption Band Using Multiplexed Metal Structures (2012)

Perfect light absorptions can be achieved with metal-dielectric-metal structures. The perfect absorption wavelength is determined by the surface plasmon resonance in the structure. By incorporating multiple surface plasmon resonances, wide spectral band perfect light absorption can be achieved. In this talk, we will discuss how multiplexed metal nanostructures control the absorption spectral bands.
Attitude control for a combine harvester: a cascade scheme approach (2022)

Modern agricultural vehicles are complex machines that require many automatic controls. Combine harvesters are particularly challenging from a control perspective. A critical control problem in combines is chassis leveling. Keeping the chassis level with respect to the gravity enhances both the crop processing efficiency and the vehicle safety. This paper presents a leveling control algorithm based on switching hydraulic actuators. A gray-box system identification is first performed, and the regulator is designed as a two-layer cascade scheme. Closed-loop experimental tests on the real vehicle prove the effectiveness of the designed controller, showing a reduction of ≈ 40% in terms of root mean square error of the roll angle, with respect to an uncontrolled case.
Stereoselective Total Synthesis of (+)-Streptazolin by Using a Temporary Silicon-Tethered RCM Strategy (2006)

A stereoselective total synthesis of (+)-streptazolin 1 was accomplished starting from readily available aminocyclopentenol (-)-7. The synthetic sequence highlights an intramolecular aldol condensation strategy to construct the piperidine core and a silicon-tethered ring-closing metathesis strategy to install the Z exocyclic ethylidene side chain of streptazolin. Separate protodesilylation and Tamao oxidation of a common intermediate 32 afforded streptazolin and the precursor for 13-hydroxystreptazolin. The overall yield for (+)-streptazolin 1 from aminocyclopentenol (-)-7 was 4.8% for a total of 16 steps.
Development of an analytical method of organochlorine pesticides in human bloods using head space solid phase microextraction coupled with gas chromatography mass spectrometry (2008)

The analytical method of extracting compounds from human blood to examine accumulated organochlorine pesticides (OCPs) has been widely used the traditional liquid-liquid extraction (LLE) method and solid-phase extraction (SPE) method, yet these methods have certain limitations in purification and usafe of a large amount of sample. In order to overcome the se problems reside in these, solid-phase microextraction (SPME), known as a highly efficient extration method with less samples and relatively simple, was employed to collect 18 different kinds of OCPs in blood as extraction method in this study. To optimize extraction method, we examine various experimental SPME-parameters such as adsorption (fiber type, adsorption time, adsorption temperature, salting out effect), and desorption (desorption time, desorption temperature etc.). From the experimental results, the optimal conditions are as follows: fiber was polyacrylate with , adsorption time was for 5 min, adsorption optimum temperature was at , and salting out effect was NaCl with 0.1 g. MDL, precision and accuracy was in the ranges of 0.05~0.20 ng/mL, 5.59~13.39%, respedively, and accuracy was -0.5% ~24.5% for all OCPs.
Synthesis of Modified Oligonucleotides and Conjugates (2004)

Peer Reviewed
Concomitant hyperthermia and radiation therapy for treating locally advanced rectal cancer (2009)

Further studies are needed to compare chemoradiation versus thermoradiation versus chemoradiation plus hyperthermia in well selected/conducted and quality controlled randomised trials.
Amorphe Kunststoffe – auf dem Sprung zu holographischen Massenanwendungen (1997)

High‐density‐Speicherung und Echtzeitholographie als Massenanwendungen der Holographie scheinen erstmals mit nichtkristallinen organischen photorefraktiven Materialien möglich. Die physikalischen Kenndaten dieser immer stärker in den Blickpunkt des Interesses rückenden Materialien kommen denen ihrer anorganischen Analoga sehr nahe, übertreffen sie sogar in mancher Hinsicht.
Multiview mm-Wave Imaging With Augmented Depth Camera Information (2018)

This paper introduces a hybrid method that combines two 3-D imaging methods of very different nature but complementary. On the one hand, a depth camera, also known as RGB-D camera, is used in order to obtain a 3-D scan of the target under test. On the other hand, a synthetic aperture radar at millimeter-wave frequency band is used to exploit the penetration capabilities of these waves, allowing electromagnetic imaging. As a result, the system can provide two complementary and aligned 3-D models. In contrast to the previous work, in which the position estimation and the external 3-D model relied on conventional optical cameras, this setup can construct the model even in the case of flat textures as it does not resort to color information at any stage. Several examples, in which the millimeter-wave scanner is validated by raster scan, are presented for people screening revealing the validity of the approach.
Impact of strain-temperature stress on ultrathin oxide (2006)

The effects of strain-temperature stress on the interfacial characteristics of ultrathin SiO/sub 2/ films on Si substrates were investigated in this brief. Both tensile and compressive strains were respectively applied on films at evaporated temperature. Quality improvement could be observed in the tensile one but degradation in another.
Briarellins J−P and Polyanthellin A:  New Eunicellin-Based Diterpenes from the Gorgonian Coral <i>Briareum polyanthes</i> and Their Antimalarial Activity (2003)

A new chemical study of the hexane extract of the gorgonian Briareum polyanthes collected in Puerto Rico afforded 10 new diterpenes of the eunicellin class, briarellins 1−9 and polyanthellin A (10), along with the known diterpene briarellin D (11). The structures and relative stereochemistry of metabolites 1−10 were assigned on the basis of NMR studies, chemical methods, and comparisons to the spectral properties of 11. A reassessment of prior structural assignment for briarellin A and two known sclerophytin-type diterpenes, 13 and 14, is proposed. Antimalarial tests on 1−6 and 8−12 indicated that they were active against Plasmodium falciparum.
Correlation of estrogen and serum bilirubin on postmenopausal women with coronary heart disease (2013)

Objective To study the correlation of estrogen and serum bilirubin with occurrence of coronary heart disease among the postmenopausal women.Methods One hundred and six suspicious postmenopausal female patients with coronary heart disease were selected.They were divided into CHD group (51 cases) and non-CHD group (55 cases)according to the result of coronary angiography.Compare the levels of Estradiol (E2),total bilirubin (TBIL),direct bilirubin (DBIL),indirect bilirubin (IBIL) in the two groups.Results The levels of E2,TBIL were lower in CHD group than those of non-CHD group (P ＜ 0.05).The difference of DBIL and TBIL had no statistically significant difference between the two groups (P ＞ 0.05).Conclusions The low level of estrogen and bilirubin may involve in the occurrence of coronary heart disease among postmenopausal women.Estrogen plays an important role in the bilirubin metabolism of women.

Key words: 
Estrogen ;  Serum bilirubin ;  Postmenopausal women ;  Coronary heart disease
Sparse cliques trump scale-free networks in coordination and competition (2016)

Cooperative behavior, a natural, pervasive and yet puzzling phenomenon, can be significantly enhanced by networks. Many studies have shown how global network characteristics affect cooperation; however, it is difficult to understand how this occurs based on global factors alone, low-level network building blocks, or motifs are necessary. In this work, we systematically alter the structure of scale-free and clique networks and show, through a stochastic evolutionary game theory model, that cooperation on cliques increases linearly with community motif count. We further show that, for reactive stochastic strategies, network modularity improves cooperation in the anti-coordination Snowdrift game and the Prisoner's Dilemma game but not in the Stag Hunt coordination game. We also confirm the negative effect of the scale-free graph on cooperation when effective payoffs are used. On the flip side, clique graphs are highly cooperative across social environments. Adding cycles to the acyclic scale-free graph increases cooperation when multiple games are considered; however, cycles have the opposite effect on how forgiving agents are when playing the Prisoner's Dilemma game.
POLYMERIC-METALLIC COMPOSITE MEMBRANES FOR HIGH-TEMPERATURE APPLICATIONS (2001)

Develop a polymeric based membrane that can withstand greater temperatures and pressures than current materials
Delay, cost and infrastructure tradeoff of epidemic routing in mobile sensor networks (2010)

This paper studies the delay, cost and infrastructure tradeoff of epidemic routing in mobile sensor networks. We consider a mobile sensor network with M mobiles and B static base stations. The mobile sensors collect information when moving around and need to report the information to the base stations. Three different epidemic routing schemes --- target epidemic routing, uncontrolled epidemic routing and controlled epidemic routing --- are analyzed in this paper. For each of the three schemes, we characterize the scaling behaviors of the delay, which is defined to be the average number of time slots required to deliver a message, and the cost, which is defined to be the average number of transmissions required to deliver a message, in terms of the number of mobiles (M) and the number of base stations (B). These scaling results reveal the fundamental tradeoff among delay, cost and infrastructure in mobile sensor networks.
Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry: New Technology for Vascular Pathology (2014)

The use of matrix-assisted laser desorption/ionization imaging mass spectrometry (MALDI-IMS) for the assessment of vascular pathology is attracting attention as a new valuable tool for diagnosing disease and finding new markers. MALDI-IMS is a molecular imaging technique whereby the simultaneous measurement of multiple samples directly from clinical tissue sections is possible. The versatility of MALDI-IMS has opened a new frontier in vascular pathology. In this review, we describe the principle and applications of MALDI-IMS.
Understanding tumor-stroma interplays for targeted therapies by armed mesenchymal stromal progenitors: the Mesenkillers. (2011)

A tumor represents a complex structure containing malignant cells strictly coupled with a large variety of surrounding cells constituting the tumor stroma (TS). In recent years, the importance of TS for cancer initiation, development, local invasion and metastases has become increasingly clear allowing the identification of TS as one of the possible ways to indirectly target tumors. Inside the heterogeneous stromal cell population, tumor associated fibroblasts (TAF) play a crucial role providing both functional and supportive environments. During both tumor and stroma development, several findings suggest that TAF could be recruited from different sources such as locally derived host fibroblasts, via epithelial/endothelial mesenchymal transitions or from circulating pools of fibroblasts deriving form mesenchymal progenitors, namely mesenchymal stem/stromal cells (MSC). These insights prompted scientists to identify multimodal approaches to target TS by biomolecules, monoclonal antibodies, and more recently via cell based strategies. These latter strategies appear extremely promising, although still associated with debated and unclear findings. This review discusses crosstalk between cancers and their stroma, dissecting specific tumor types, such as sarcoma, pancreatic and breast carcinoma, where stroma plays distinct paradigmatic roles. The recognition of these distinct stromal functions may help in planning effective and safer approaches aimed either to eradicate or to substitute TS by novel compounds and/or MSC having specific killing activities.
Integrated Camera-Based Navigation (2000)

This paper presents an integrated INS (Inertial Navigation System) and camera-based navigation system. The camera-based navigation system provides position measurement aiding to the INS. This is an alternative to the more conventional GPS (Global Positioning System) aided INS. The system is intended for UAVs (Unmanned Aerial Vehicles) and long-range missiles. The basic principles of camera-based navigation are presented. The Kalman filter based integration of INS and camera-based navigation is discussed. Total system simulation results are shown together with INS simulations for comparison. Finally, a brief overview of factors that improve the navigation accuracy is presented.
Spatial Dimensions of Dengue Virus Transmission across Interepidemic and Epidemic Periods in Iquitos, Peru (1999–2003) (2012)

Seroprevalence of previously circulating DENV serotypes can be a predictor of transmission risk for a different invading serotype and, thus, identify targets for strategically placed surveillance and intervention. Seroprevalence of a specific serotype is also important, but does not preclude other contributing factors, such as mosquito density, in determining where transmission of that virus will occur. Regardless of the epidemiological context or virus serotype, human movement appears to be an important factor in defining the spatial dimensions of DENV transmission and, thus, should be considered in the design and evaluation of surveillance and intervention strategies.