gebhart/patrepeval huggingface dataset:
Feedback linearizing excitation control on a full-scale power system model (1994)

A type of feedback linearizing excitation control is simulated on a very large (5000-bus) model of the Northeast Power Coordinating Council System. The control is implemented on two groups of machines, one in the New York City/Long Island area and one in the Lake Ontario area of New York State. A series of system faults is simulated, the most serious involving the loss of a very large portion of the transmission capacity from Northwest New York State to the New York City area, under extreme loading conditions. The nonlinear control prevents a breakup of the system which would otherwise result in a widespread blackout, at the expense of a rise in the system voltage at the Lake Ontario end. Simulations are also run with PSS/static exciter combinations on the same groups of generators, as a rough comparison of the performance of conventional vs. feedback linearizing control.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Data Supplement from NEO212, Temozolomide Conjugated to Perillyl Alcohol, Is a Novel Drug for Effective Treatment of a Broad Range of Temozolomide-Resistant Gliomas (2023)

&lt;p&gt;Supplementary Figure 6. PARP inhibitor is not cytotoxic to U251 cells&lt;/p&gt;
Effects of combined neutral endopeptidase 24‐11 and angiotensin‐converting enzyme inhibition on femoral vascular conductance in streptozotocin‐induced diabetic rats (2000)

1. The successive effects of the angiotensin-converting enzyme inhibitor captopril (CAP, 2 mg kg(-1)+1 mg kg(-1) 30 min(-1) infusion) and the neutral endopeptidase 24-11 inhibitor retrothiorphan (RT, 25 mg kg(-1)+12.5 mg kg(-1) 30 min(-1) infusion) were studied on femoral vascular conductance (FVC) in streptozotocin-induced diabetic (STZ-SD) and control Sprague-Dawley (C-SD) rats. The role of the kinin-nitric oxide (NO) pathway was assessed by (1) using pre-treatments: a bradykinin (BK) B2 receptor antagonist (Hoe-140, 300 microg kg(-1)), a NO-synthase inhibitor (N(omega)-nitro-L-arginine methyl ester, L-NAME, 10 mg kg(-1)), a kininase I inhibitor (DL-2-mercaptomethyl-3-guanidinoethylthiopropanoic acid, MGTA, 10 mg kg(-1)+20 mg kg(-1) 20 min(-1) infusion) and (2) comparing the effects in STZ-induced diabetic (STZ-BN) and control Brown-Norway kininogen-deficient (C-BN) rats. 2. In C-SDs, CAP and CAP+RT increased FVC similarly. In STZ-SDs, FVC and FBF were decreased compared to C-SDs. CAP+RT increased them more effectively than CAP alone. 3. In both C-SDs and STZ-SDs, the femoral bed vasodilatation elicited by CAP was inhibited by Hoe-140 and L-NAME. The FVC increase elicited by CAP+RT was not significantly reduced by Hoe-140 but was inhibited by L-NAME and Hoe-140+MGTA. 4. In C-BNs, the vasodilatator responses to CAP and CAP+RT were abolished and highly reduced, respectively. In STZ-BNs, these responses were abolished. 5. These results show that in STZ-SDs, CAP+RT improve FBF and FVC more effectively than CAP alone. These effects are linked to an increased activation of the kinin-NO pathway. BK could lead to NO production by BK B2 receptor activation and another pathway in which kininase I may be involved.
Hyperglycemia Independently Increases the Risk of Perioperative Stroke, Myocardial Infarction, and Death after Carotid Endarterectomy (2006)

Independent of previous cardiac disease, diabetes, or other comorbidities, hyperglycemia at the time of CEA was associated with an increased risk of perioperative stroke or transient ischemic attack, myocardial infarction, and death. Strict glucose control should be attempted before surgery to minimize the risk of morbidity and mortality after CEA.
ADP Receptor Antagonists and Converting Enzyme Systems Reduce Platelet Deposition onto Collagen (1992)

The effect of the ADP receptor antagonists ATP and adenosine 5'-(beta, gamma-methylene)triphosphate (AMP-PCP), and the ADP-utilizing enzyme systems creatine phosphokinase/creatine phosphate (CPK/CP) and pyruvate kinase/phosphoenol pyruvate (PK/PEP) on platelet deposition onto type I collagen was examined. An in vitro perfusion system was used, which allowed continuous visualization of the deposition of fluorescently labelled platelets. This system also provide well-controlled rheology, precise quantification of deposition, and allowed the use of heparinized whole human blood (3 u/ml). Heparinization at this level permits the local generation of thrombin near surface platelet aggregates. The contribution of ADP is thus studied with the combined effects of thrombin, thromboxane A2, and other aggregating agents present. Results from these studies indicate that ATP was capable of inhibiting deposition by 60% at 1 microM and 90% at 5 microM (whole blood conc.). AMP-PCP inhibited deposition in a dose dependent manner with a Ki of approximately 80 microM and a maximum inhibition of 60%. Inhibition by CPK/CP was measured at 20, 40, and 60 u/ml, with approximately 45% inhibition achieved for the latter two concentrations. PK/PEP at 60 u/ml resulted in 70% inhibition. These results support a role for ADP in mediating platelet recruitment in thrombus growth on collagen. Previous work utilizing animal bleeding times supports this conclusion; the present study demonstrates that this role is not dependent upon endothelial or vasoconstrictive effects. Intraplatelet cAMP levels were raised with respect to controls upon exposure to ATP at 8.3 microM (p less than 0.025), and 15 microM (p less than 0.005), as well as AMP-PCP at 42-500 microM (p less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
Microwave apparatus for phase transition studies of corrosive fluids to 1.7 kbar and 588 K (1985)

A microwave apparatus for phase boundary determinations of corrosive fluid mixtures to 1.7 kbar and 588 K is described. The apparatus measures shifts in a static microwave energy field caused by changes in sample dielectric properties. The measured interactions involve the entire sample cell; sample volumes are small (∼25 cm3); phase transitions are measured directly. Details of the microwave apparatus and the microwave technique are discussed. Data are presented for pure fluids and for an acid-gas/heavy oil mixture that demonstrate the performance of the apparatus.
Hybrid Materials and Periodic Mesoporous Organosilicas Containing Covalently Bonded Organic Anion and Cation Featuring MCM-41 and SBA-15 Structure (2009)

We report the synthesis of a new trialkoxysilylated ionic liquid based on disilylated guanidinium and monosilylated sulfonimide species. This compound allowed the successful preparation of new periodic mesoporous organosilicas containing covalently anchored ion-pair through both organo-cationic and organo-anionic moieties which have never been reported up to now. Two classes of hybrid materials containing guanidinium-sulfonimide ion-pairs (IPs) have been synthesized. The first type of material was prepared by grafting the silylated IP onto both MCM-41-type and SBA-15-type silicas according to a surface sol-gel polymerization. The second class was synthesized following a one-pot sol-gel procedure using silylated IP and tetraethoxysilane as framework precursors. These latter materials correspond to so-called periodic mesoporous organosilicas (PMOs) and gave "organo-ionically" modified MCM-41 and SBA-15 related solids. The materials were characterized by a series of techniques including XRD, nitrogen sorption, solid-state NMR, FTIR, transmission electronic microscopy, and elemental analysis. The highest structural regularity in terms of pore size distribution and channel size homogeneity was observed for IP-PMOs possessing SBA-15-type architecture due to an enhanced trialkoxysilylated IP precursor/surfactant interaction. Solvatochromic experiments with Reichardt's dye showed good accessibility of the silica-supported ion-pair and suggested the formation of monophasic materials.
Exponential asymptotically bounded velocity model (2004)

A new vertical velocity model, representing the effect of gradually increasing velocities with depth in compacted sediment layers, is proposed. It is an asymptotically bounded exponential model defined by three intuitive parameters per each layer (interval). The parameters are the velocity and its vertical gradient at the top interface, and the bounded velocity value. The proposed model provides a basis for describing the subsurface by a smaller number of thick layers than the classical linear velocity models. The velocity is assumed to be a continuous function. However, discontinuities are allowed at some layer interfaces, such as the sea bottom, or in transition zones mainly due to high pore pressure. We first define the instantaneous velocity function and the corresponding effective models within a single layer (interval). The effective models are the average, RMS and fourth‐order average velocities. We then derive the inversion procedure to obtain constrained and stable velocity models from the different types of effective models.
Acoustic Voice and Speech Biomarkers of Treatment Status during Hospitalization for Acute Decompensated Heart Failure (2023)

This study investigates acoustic voice and speech features as biomarkers for acute decompensated heart failure (ADHF), a serious escalation of heart failure symptoms including breathlessness and fatigue. ADHF-related systemic fluid accumulation in the lungs and laryngeal tissues is hypothesized to affect phonation and respiration for speech. A set of daily spoken recordings from 52 patients undergoing inpatient ADHF treatment was analyzed to identify voice and speech biomarkers for ADHF and to examine the trajectory of biomarkers during treatment. Results indicated that speakers produce more stable phonation, a more creaky voice, faster speech rates, and longer phrases after ADHF treatment compared to their pre-treatment voices. This project builds on work to develop a method of monitoring ADHF using speech biomarkers and presents a more detailed understanding of relevant voice and speech features.
High Efficiency R-744 Commercial Heat Pump Water Heaters (2013)

The project investigated the development and improvement process of a R744 (CO2) commercial heat pump water heater (HPWH) package of approximately 35 kW. The improvement process covered all main components of the system. More specific the heat exchangers (Internal heat exchanger, Evaporator, Gas cooler) as well as the expansion device and the compressor were investigated. In addition, a comparison to a commercially available baseline R134a unit of the same capacity and footprint was made in order to compare performance as well as package size reduction potential.
The TCGA Meta-Dataset Clinical Benchmark (2019)

Machine learning is bringing a paradigm shift to healthcare by changing the process of disease diagnosis and prognosis in clinics and hospitals. This development equips doctors and medical staff with tools to evaluate their hypotheses and hence make more precise decisions. Although most current research in the literature seeks to develop techniques and methods for predicting one particular clinical outcome, this approach is far from the reality of clinical decision making in which you have to consider several factors simultaneously. In addition, it is difficult to follow the recent progress concretely as there is a lack of consistency in benchmark datasets and task definitions in the field of Genomics. To address the aforementioned issues, we provide a clinical Meta-Dataset derived from the publicly available data hub called The Cancer Genome Atlas Program (TCGA) that contains 174 tasks. We believe those tasks could be good proxy tasks to develop methods which can work on a few samples of gene expression data. Also, learning to predict multiple clinical variables using gene-expression data is an important task due to the variety of phenotypes in clinical problems and lack of samples for some of the rare variables. The defined tasks cover a wide range of clinical problems including predicting tumor tissue site, white cell count, histological type, family history of cancer, gender, and many others which we explain later in the paper. Each task represents an independent dataset. We use regression and neural network baselines for all the tasks using only 150 samples and compare their performance.
Nano-composites reforzados con microfibrillas de celulosa aisladas de paredes celulares del raquis de banano (2007)

En este trabajo, se aislaron microfibrilllas de celulosa (MFC) del raquis de banano empleando tratamiento quimico con hidroxido de potasio al 5%. Estas fueron usadas como reforzantes del polipropileno, para elaborar nanocomposites por mezclado en via liquida y compresion en caliente. Las microfibrillas fueron caracterizadas empleando espectroscopia infrarroja por transformada de Fourier (FTIR) y analisis termogravimetrico (TGA). Empleando microscopia de fuerza atomica (AFM) se ha establecido que los diametros de las microfibrillas se encuentran entre 5 – 10 nm, los ensayos de traccion de los nanocomposites desarrollados reflejan incrementos en el desempeno mecanico debidos a la presencia de las microfibrillas aisladas.
Synthesis and characterization of monodisperse uniformly shaped respirable aerosols (2013)

The top‐down, micromolding technique, referred to as Particle Replication in Nonwetting Templates (PRINT ® ), affords a new opportunity for the generation of inhalation therapeutics. Powders were fabricated with predetermined particle size and shape; when dispersed with a collision jet nebulizer, these particles resulted in monodisperse aerosols with geometric standard deviations well below 1.2. Dynamic shape factors for this novel set of uniformly shaped particles were determined by correcting the drag of nonspherical particles in the ultra‐Stokesian flow conditions of the aerodynamic particle sizer (APS). This convenient approach for shape factor determination agreed well with current literature approaches and allowed for the correction of APS results for particles with known volumes. Determined shape factor values of PRINT geometries were used to estimate the theoretical median aerodynamic diameters of individual aerosols, which were then compared to actual inhalation powders. © 2013 American Institute of Chemical Engineers AIChE J , 59: 3184–3194, 2013
Systematic CMA of the U-slot Patch with FEKO (2020)

Since its introduction 25 years ago, the probe-fed U-slot patch antenna has remained popular. Recently, Characteristic Mode Analysis (CMA) revealed these devices are governed by Coupled Mode Theory (CMT). Although this principle is conceptually simple, achieving this understanding is only possible through a systematic analysis using CMA. This paper uses the U-slot patch to illustrate a general process for analyzing electrically small antennas using CMA with the software package FEKO.
104 Elevator System with Self-diagnosis and Auto-recovery after the Occurrence of Earthquake (2007)

A new earthquake recovery system for the elevator has been developed and started the service. This system automatically diagnoses the halted elevator by the earthquake emergency operation, and then it tries to recover the operation normally if it doesn't detect any malfunctions. When a big earthquake occurs, many elevators have to stop their services until maintenance worker's check. It causes a long waiting time for the normal operation. The developed system can check the elevator condition by itself within about 30 minutes. Therefore it improves the user's availability by the quick recovery after the occurrence of earthquake.
Revision of MOSCED Parameters and Extension to Solid Solubility Calculations (2005)

New pure component parameters are presented for the MOSCED limiting activity coefficient model for 133 solvents with an absolute average deviation of 10.6% to experimental literature data. The MOSCED model has been applied to solid−liquid equilibria correlation and compared with the experimental data available in the literature. The correlation of solubility of 26 solids in organic solvents has an average absolute deviation of 25%. This compares favorably to the prediction of the modified UNIFAC model.
Assessment of particle-migration effects in pressure-driven viscometric flows (2000)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Melquiades Allende, Dilhan M. Kalyon; Assessment of particle-migration effects in pressure-driven viscometric flows. J. Rheol. 1 January 2000; 44 (1): 79–90. https://doi.org/10.1122/1.551074 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentThe Society of RheologyJournal of Rheology Search Advanced Search |Citation Search
Total synthesis of a virotoxin and analogs for conformational studies (2012)

This dissertation describes the first total synthesis of alloviroidin in trace amounts, along with that of three analogs containing L-proline (Pro), trans-3-hydroxyproline (3-Hyp) or cis-4-hydroxyproline (4-hyp) residue substituting for 2,3-trans-3,4-trans-dihydroxyproline in the natural product. We report herein an efficient strategy that provides a dipeptide containing a (2S,4S)-4,5-dihydroxyleucine (dihyLeu) residue, including a diastereoselective dihydroxylation. Nα-Carbobenzyloxy-(2S)-4,5-dehydroleucine was coupled with valine ethyl ester to give a dipeptide that was subjected to a Sharpless asymmetric dihydroxylation to introduce the diol. The relative configuration at C4 was assigned as S by X-ray crystallography after derivatization as an α-amino-γ-lactone hydrochloride salt. The preparation of the 2-(methylsulfonyl)tryptophan residue is described followed by incorporation into a tetrapeptide, Fmoc-Ala-[2-MeSO2]-Trp-diHyLeu(OTBS)-Val-OEt. An efficient synthesis of four tripeptide fragments is also described: Fmoc-D-Thr(OTBS)-D-Ser(OTBS)-Pro*-OBn, where Pro* represents Pro, 3-Hyp, 4-hyp and DHP. These tripeptides were assembled via a [2+1] coupling between Fmoc-D-Thr(OtBu)-D-Ser(OtBu)-OH and the appropriate proline benzyl ester. The acid labile side-chain protecting groups were swapped out for fluoride-labile silyl ethers. Linear heptapeptides were prepared via [3+4] fragment condensations between the series of four tripeptide acids Fmoc-D-Thr(OTBS)-D-Ser(OTBS)-Pro*-OH and the tetrapeptide amine H-Ala-[2-MeSO2-Trp]-diHyLeu(OTBS)-Val-OEt. Deprotection of the N- and C-terminii, followed by cyclization and global side chain deprotection generated our target cyclopeptides. Removal of excess TBAF reagent and salts formed as byproducts during ethyl ester and silyl ether deprotections was achieved by treatment with DOWEX 50WX8-400 H+ resin and calcium carbonate. This procedure led to reasonable yields of the three analogs but afforded only trace amounts of the natural product after HPLC purification. We examined the conformational preferences of dipeptide fragments Ac-D-Ser-Pro*-NHMe (in both free and TBS protected side chains of D-Ser and Pro* residues) using computational studies. The computational analyses confirm that the ratio of trans:cis conformers varies with the degree, regio- and stereochemistry of proline hydroxylation. These equilibrium constant about the prolyl amide bond calculated for these dipeptides are in qualitative agreement with those determined by NMR for tripeptides Fmoc-D-Thr-D-Ser-Pro*-OBn (in both free and TBS protected side chains).
Respective role of antithrombin III and heparin cofactor II in the in vitro anticoagulant effect of heparin and of various sulphated polysaccharides (1986)

The in vitro anticoagulant effects of standard heparin (SH) and of seven other sulphated polysaccharides (SPS) were investigated by measuring activated partial thromboplastin time (APTT) prolongation of normal plasma and of plasmas selectively depleted of antithrombin III (AT III), of heparin cofactor II (HC II) and of both heparin cofactors. This allowed the determination of the relative contribution of each of the two heparin cofactors to the SPS anticoagulant effect. The SPS varied in their relative activities as catalysts of thrombin inhibition by purified AT III or HC II. The anticoagulant activities of heparin and dermatan sulphate were primarily attributable to their ability to enhance thrombin inhibition by AT III and HC II respectively. Heparin had an additional minor anticoagulant activity which was independent of both AT III and HC II. Pentosan polysulphate, high molecular weight dextran sulphate, heparin with low affinity for AT III and a sulphated heparin derivative had weaker anticoagulant activities in normal plasma than standard heparin. The anticoagulant activities of these last four SPS in plasma depleted of both AT III and HC II were similar to their respective activities in normal plasma. This suggests that these SPS act by directly preventing thrombin generation rather than by enhancing thrombin inhibition.
Agnostic Life Finder (ALF) for Large-Scale Screening of Martian Life During <i>In Situ</i> Refueling (2022)

Before the first humans depart for Mars in the next decade, hundreds of tons of martian water-ice must be harvested to produce propellant for the return vehicle, a process known as <i>in situ</i> resource utilization (ISRU). We describe here an instrument, the Agnostic Life Finder (ALF), that is an inexpensive life-detection add-on to ISRU. ALF exploits a well-supported view that informational genetic biopolymers in life in water must have two structural features: (1) Informational biopolymers must carry a repeating charge; they must be <i>polyelectrolytes.</i> (2) Their building blocks must fit into an <i>aperiodic crystal structure;</i> the building blocks must be size-shape regular. ALF exploits the first structural feature to extract polyelectrolytes from ∼10 cubic meters of mined martian water by applying a voltage gradient perpendicularly to the water's flow. This gradient diverts polyelectrolytes from the flow toward their respective electrodes (polyanions to the anode, polycations to the cathode), where they are captured in cartridges before they encounter the electrodes. There, they can later be released to analyze their building blocks, for example, by mass spectrometry or nanopore. Upstream, martian cells holding martian informational polyelectrolytes are disrupted by ultrasound. To manage the (unknown) conductivity of the water due to the presence of salts, the mined water is preconditioned by electrodialysis using porous membranes. ALF uses only resources and technology that must <i>already</i> be available for ISRU. Thus, life detection is easily and inexpensively integrated into SpaceX or NASA ISRU missions.
New non-toxic holographic photopolymer material (2011)

There is an increasing need for environmentally friendly holographic recording materials which can be produced in bulk with little risk to the health of workers in manufacturing. This is why the development of non-toxic photopolymer materials is crucial, and has attracted attention in recent years. Composition and preliminary characterization of a new non-toxic photopolymer material are presented. It operates well at a range of spatial frequencies, and achieves diffraction efficiencies and refractive index modulation comparable to the known acrylamide-based photopolymers.