gebhart/patrepeval huggingface dataset:
Composition of Lipopolysaccharides from Various Strains of Rhodomicrobium vannielii (1986)

Abstract The compositions of lipopolysaccharides from the photoheterotrophic budding Rhodomi­crobium vannielii strains DSM 162, Rm5, E3 and 2/1 are reported. Common constituents of these lipopolysaccharides are glucose, mannose, glucosamine, glucuronic and galacturonic acids, 2-keto-3-deoxyoctonate (KDO) and the fatty acids 3-OH-C 16 :0, 3-OH-C 14 :0, C 14 :0, Δ 14 -C 22 :1, aside from strain specific differences. Two different, medium-dependent growth forms of strain DSM 162 are described. The vitamin/ yeast extract-concentration in the medium and/or the growth temperature were found as factors triggering the different growth forms. Lipopolysaccharides of the two growth forms had only quantitative differences in composition. Lipopolysaccharide from swarmer cells of strain Rm5 showed a chemical composition comparable to that of chain cells and from simple cycle cells of the same strain.
Warren Blazier and his contributions to noise rating criteria (2013)

Warren Blazier was well known for his work with sound and vibration in mechanical systems, e.g., HVAC equipment. As such, he was particularly active at ASHRAE in addition to the ASA meetings. Although I was always focused more on the “room acoustics” side of the design, I none-the-less offered to help edit the 1999 ASHRAE Handbook chapter 43 with Warren and Chuck Ebbing. This section dealt with “Indoor Sound Criteria,” and what an eye opening event this turned out to be. You might say that I jumped into the fire as there was an ongoing “tug-of-war” over which rating system should be adopted to describe background noise in buildings from mechanical systems. NC, RC, RC mark II, NCB … several of these had been used up to this point and lots of controversy existed as to what to include in the re-write. A somewhat historic special meeting of ASHRAE TC2.6 was held in Boston on the evening of Sunday 27 June 1997 from 3:30 to 6:30 pm where this was discussed to resolve the issue. Both Warren and Leo Beranek were asked to make presentations on the merits of the competing approaches. And this is what was decided!!
A viscoplastic model for metal matrix composites subjected to cyclic loading (1998)

A viscoplastic model for Metal Matrix Composites based on the micromechanical theory is outlined here. The model accounts for the strong directional dependent properties that these materials have by considering a constrained stress term. Evolution equations for the viscoplastic strain rate and a new form for the evolution of equilibrium stress is shown. An explicit forward time integration procedure is used. Numerical simulations along with experimental comparisons are done at this time for the case where both the components of the composite are treated as being the same material in order to simulate the matrix behavior. Predictions for the composite behavior are presented using this model.
Robustification against Incorrespondence Points for Scale Reconstructible SfM Using Refraction (2018)

Structure from Motion (SfM) is a three-dimensional reconstruction method which uses a moving camera. However, it cannot estimate the real-world scales of objects. To solve this problem, in our previous studies, a scale reconstructible SfM method using refraction was proposed. However, our previous method is not robust against measurement errors. In particular, a few inaccurate correspondence points cause reconstruction failure. In this paper, we improved the robustness against large measurement errors by introducing 17 points RANSAC.
Dry etching of GaSb and InSb in (1997)

Etch rates of are obtained for both GaSb and InSb in electron cyclotron resonance discharges. The GaSb surfaces remain smooth and stoichiometric over a wide range of plasma conditions (microwave power 400 - 1000 W, pressure 1.5 - 10 mTorr, to ratio 0.1 - 1.5). However, we were unable to prevent preferential loss of Sb from InSb causing rough, non-stoichiometric surfaces under all conditions investigated. It appears that low-profile electromagnet ECR sources are not good choices for -based dry etching of InSb.
ChemInform Abstract: Diethylaluminum Ethoxide Mediated Stereoselective Diels—Alder Reaction of α,β‐Unsaturated Ketones and Acetoxy‐1,3‐butadienes as Diene Components. (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Faculty Opinions recommendation of Control of root system architecture by DEEPER ROOTING 1 increases rice yield under drought conditions. (2013)

The genetic improvement of drought resistance is essential for stable and adequate crop production in drought-prone areas. Here we demonstrate that alteration of root system architecture improves drought avoidance through the cloning and characterization of DEEPER ROOTING 1 (DRO1), a rice quantitative trait locus controlling root growth angle. DRO1 is negatively regulated by auxin and is involved in cell elongation in the root tip that causes asymmetric root growth and downward bending of the root in response to gravity. Higher expression of DRO1 increases the root growth angle, whereby roots grow in a more downward direction. Introducing DRO1 into a shallow-rooting rice cultivar by backcrossing enabled the resulting line to avoid drought by increasing deep rooting, which maintained high yield performance under drought conditions relative to the recipient cultivar. Our experiments suggest that control of root system architecture will contribute to drought avoidance in crops. PMID: 23913002
Norepinephrine and histamine potentiate the increases in cyclic adenosine 3':5'-monophosphate elicited by vasoactive intestinal polypeptide in mouse cerebral cortical slices: mediation by alpha 1- adrenergic and H1-histaminergic receptors (1985)

We have examined the interactions, in eliciting cAMP accumulation, between vasoactive intestinal polypeptide (VIP) and the three monoamines norepinephrine (NE), histamine (HIS), and serotonin (5-hydroxytryptamine, 5-HT) in mouse cerebral cortical slices. We have observed that NE and HIS, but not 5-HT, act synergistically with VIP to increase cAMP levels. The rank-order of potency of several adrenergic agonists in potentiating the effect of VIP on cAMP levels is the following: epinephrine greater than NE greater than phenylephrine much greater than clonidine, with EC50 of 2.2, 5, and 10 microM, respectively (clonidine being only marginally effective). This pharmacological profile is characteristic of the activation of alpha 1-adrenergic receptors. This contention is substantiated by the observation that the potentiating effect of NE is antagonized by the selective alpha 1-adrenergic antagonist prazosin at nanomolar concentrations. The potentiating effect of HIS is mediated by H1-histaminergic receptors since it is antagonized by the selective H1-receptor antagonist mepyramine but not by cimetidine, a selective H2-receptor antagonist. The synergistic interaction between VIP and NE is also observed in the presence of the adenosine antagonist theophylline, thus discarding the possibility of a mediation of the synergism by adenosine released by VIP.(ABSTRACT TRUNCATED AT 250 WORDS)
Pharmacological inhibition of 17β-hydroxysteroid dehydrogenase impairs human endometrial cancer growth in an orthotopic xenograft mouse model (2021)

Endometrial cancer (EC) is the most common gynaecological tumor in developed countries and its incidence is increasing. Approximately 80% of newly diagnosed EC cases are estrogen-dependent. Type 1 17β-hydroxysteroid dehydrogenase (17β-HSD-1) is the enzyme that catalyzes the final step in estrogen biosynthesis by reducing the weak estrogen estrone (E1) to the potent estrogen 17β-estradiol (E2), and previous studies showed that this enzyme is implicated in the intratumoral E2 generation in EC. In the present study we employed a recently developed orthotopic and estrogen-dependent xenograft mouse model of EC to show that pharmacological inhibition of the 17β-HSD-1 enzyme inhibits disease development. Tumors were induced in one uterine horn of athymic nude mice by intrauterine injection of the well-differentiated human endometrial adenocarcinoma Ishikawa cell line, modified to express human 17β-HSD-1 in levels comparable to EC, and the luciferase and green fluorescent protein reporter genes. Controlled estrogen exposure in ovariectomized mice was achieved using subcutaneous MedRod implants that released either the low active estrone (E1) precursor or vehicle. A subgroup of E1 supplemented mice received daily oral gavage of FP4643, a well-characterized 17β-HSD-1 inhibitor. Bioluminescence imaging (BLI) was used to measure tumor growth non-invasively. At sacrifice, mice receiving E1 and treated with the FP4643 inhibitor showed a significant reduction in tumor growth by approximately 65% compared to mice receiving E1. Tumors exhibited metastatic spread to the peritoneum, to the lymphovascular space (LVI), and to the thoracic cavity. Metastatic spread and LVI invasion were both significantly reduced in the inhibitor-treated group. Transcriptional profiling of tumors indicated that FP4643 treatment reduced the oncogenic potential at the mRNA level. In conclusion, we show that 17β-HSD-1 inhibition represents a promising novel endocrine treatment for EC.
Molecular Doping Directed by a Neutral Radical (2021)

Molecular doping makes possible tunable electronic properties of organic semiconductors, yet a lack of control of the doping process narrows its scope for advancing organic electronics. Here, we demonstrate that the molecular doping process can be improved by introducing a neutral radical molecule, namely nitroxyl radical (2,2,6,6-teramethylpiperidin-i-yl) oxyl (TEMPO). Fullerene derivatives are used as the host and 1,3-dimethyl-2-phenyl-2,3-dihydro-1<i>H</i>-benzo[d]imidazoles (DMBI-H) as the n-type dopant. TEMPO can abstract a hydrogen atom from DMBI-H and transform the latter into a much stronger reducing agent DMBI<sup>•</sup>, which efficiently dopes the fullerene derivative to yield an electrical conductivity of 4.4 S cm<sup>-1</sup>. However, without TEMPO, the fullerene derivative is only weakly doped likely by a hydride transfer following by an inefficient electron transfer. This work unambiguously identifies the doping pathway in fullerene derivative/DMBI-H systems in the presence of TEMPO as the transfer of a hydrogen atom accompanied by electron transfer. In the absence of TEMPO, the doping process inevitably leads to the formation of less symmetrical hydrogenated fullerene derivative anions or radicals, which adversely affect the molecular packing. By adding TEMPO we can exclude the formation of such species and, thus, improve charge transport. In addition, a lower temperature is sufficient to meet an efficient doping process in the presence of TEMPO. Thereby, we provide an extra control of the doping process, enabling enhanced thermoelectric performance at a low processing temperature.
509 (2013)

Introduction: Therapeutic hypothermia is established to improve outcome for patients following pre-hospital cardiac arrest. Yet the rate of favorable neurological outcome still stands in only about the fiftieth percentile. The presence of short-latency somatosensory evoked potential (SSEP) N20 is useful as a prognostic evaluation for comatose patients after cardiac arrest and return of spontaneous circulation (ROSC). In this study we performed electrophysiological evaluations just after ROSC to investigate whether the presence of SSEP N20 components just before therapeutic hypothermia is a useful predictor of outcome. Methods: The study subjects were 27 comatose patients (18 males and 9 females; age 32 to 71 years old; average age 55.0) who manifested auditory brainstem response wave V after ROSC and were admitted to Nihon University Itabashi Hospital Emergency and Critical Center. After recognizing positive V wave of auditory brainstem response, two SSEP examinations were performed using bilateral stimulation applied to the median nerve at the level of the wrist with six electrodes (bilateral Erb C5, C3, C4, Fz by the International 10-20 System), once before therapeutic hypothermia and once at 24 hours after ROSC. Two sets of 1,000 stimuli were recorded. Favorable outcome (category 1 and category 2) was defined using the five-point Pittsburgh cerebral-performance category scale and evaluated at discharge. Results: All patients underwent SSEP recording within 90 minutes from ROSC. Ten (56%) of 18 patients in whom SSEP N20 was present both before therapeutic hypothermia and at 24 hours after ROSC had favorable outcome. Nine (100%) of 9 patients in whom SSEP N20 was absent both before therapeutic hypothermia and at 24 hours after ROSC had unfavorable outcome. Five (27%) of 18 patients in whom SSEP N20 was present before therapeutic hypothermia and absent at 24 hours after ROSC had unfavorable outcome. SSEP N20 was never absent at both time points. Conclusions: Electrophysiological examination is useful for comatose patients at the time point immediately after ROSC and before therapeutic hypothermia. The measurement of SSEP N20 before therapeutic hypothermia and at 24 hours after ROSC may be very useful for identifying the patients in whom favorable outcome can be expected after therapeutic hypothermia. The measurement of SSEP N20 at 24 hours after ROSC may allow us to identify the patients not likely to benefit from therapeutic hypothermia.
Cellular Thermal Shift Analysis for Interrogation of CRISPR-Assisted Proteomic Changes (2020)

CRISPR-Cas9 has proven to be a versatile tool for the discovery of essential genetic elements involved in various disease states. CRISPR-assisted dense mutagenesis focused on therapeutically challenging protein complexes allows us to systematically perturb protein-coding sequences <i>in situ</i> and correlate them with functional readouts. Such perturbations can mimic targeting by therapeutics and serve as a foundation for the discovery of highly specific modulators. However, translation of such genomics data has been challenging due to the missing link for proteomics under the physiological state of the cell. We present a method based on cellular thermal shift assays to easily interrogate proteomic shifts generated by CRISPR-assisted dense mutagenesis, as well as a case focused on NuRD epigenetic complex.
Unilateral Fracture of a 4th Generation Alumina Bearing-Ceramic Liner in a Modern Bilateral Total Hip Replacement: A Case Report (2012)

Introduction Alumina Ceramic liners are increasingly used in patients undergoing Total Hip Replacement (THR). The rate of fracture of ceramic liner is decreasing with improved manufacturing techniques from 1 st to 3 rd generation alumina-ceramic liners. We report the first case of a fracture of a modern, 4 th generation alumina bearing ceramic liner, which incorporates a metal sheath to help avoid fracture. Our case is a 60 years old female presenting two years and three months after a bilateral total hip replacement using Stryker Trident cup, securfit stem and alumina on alumina bearing ceramic liner. Ceramic liners are commonly used, especially in young patients because of their excellent biocompatibility, low wear rate and superior tribology. Although fracture of ceramic liner is a less common complication of modern total hip arthroplasty, it is a major concern with the use of ceramic on ceramic THR, the reason being brittleness of ceramic. Cases of 3 rd generation ceramic liner fracture have been reported which might be associated with impingement due to excessive anteversion of the socket in Asian patients who habitually squat. Habitual squatting, sitting cross legged and kneeling were not characteristic of this case. Methods The patient presented with complains of mechanical grinding in left hip. She also reported a past history of clicking sound from left hip on extension of left hip and long stride gait. There was no history of trauma or fall. On examination she had a nonantalgic gait and left hip had audible and palpable crepitations. The range of motion on left hip was intact with no subluxation. Right hip was symptom free and examination did not detect any abnormalities. Evaluation & Results Radiographs of left hip revealed eccentric positioning of the head [Fig. 1] within the socket and excessive anteversion of the socket, which likely caused edge-loading in extension, leading to catastrophic failure in form of fracture of ceramic liner on left hip. She was treated with revision surgery using polyethylene liner with metal head. Intra-operative findings confirmed the ceramic liner fracture [Fig. 2] and revealed impingement of the metal neck against the metal rim of the liner. Discussion & Conclusion Although ceramic on ceramic hips have excellent wear properties, it is subject to fracture due to its brittle nature. This can lead to catastrophic failure with edge loading. In this case, the alumina-ceramic liner fractured; despite of being surrounded by a metal rim to prevent fracture. It fractured at the anterior edge, which is where it was loaded in extension. We believe that careful attention must be paid not only to inclination, but version of the socket, so as to avoid this complication. Other factors which might lead to such complication are obesity, high activity level, improper manufacturing teachniques for ceramic liners and entrapment and impingement of a micromm sized foreign body between ceramic liner and prosthetic head which initiates wear.
The Transcriptional Regulatory Network of Proneural Glioma Determines the Genetic Alterations Selected during Tumor Progression (2014)

Proneural glioblastoma is defined by an expression pattern resembling that of oligodendrocyte progenitor cells and carries a distinctive set of genetic alterations. Whether there is a functional relationship between the proneural phenotype and the associated genetic alterations is unknown. To evaluate this possible relationship, we performed a longitudinal molecular characterization of tumor progression in a mouse model of proneural glioma. In this setting, the tumors acquired remarkably consistent genetic deletions at late stages of progression, similar to those deleted in human proneural glioblastoma. Further investigations revealed that p53 is a master regulator of the transcriptional network underlying the proneural phenotype. This p53-centric transcriptional network and its associated phenotype were observed at both the early and late stages of progression, and preceded the proneural-specific deletions. Remarkably, deletion of p53 at the time of tumor initiation obviated the acquisition of later deletions, establishing a link between the proneural transcriptional network and the subtype-specific deletions selected during glioma progression.
Effect of suppressor of cytokine signaling on hepcidin production in hepatitis C virus replicon cells (2011)

This in vitro study shows that SOCS-3 expression was enhanced but SOCS-1 expression was reduced by HCV infection. The upregulation of hepcidin induced by IL-6 was found to be negatively regulated by SOCS-1 and SOCS-3. The modulation of SOCS1 and SOCS3 in HCV-infected hepatocytes may explain, at least in part, the relative shortage of hepcidin production in CH-C.
Physics-Based Part Orientation and Sentencing: A Solution to Manufacturing Variability (2019)

Abstract Casting deviations introduce geometric variability that impacts the aerodynamic performance of turbomachinery. These effects are studied for a High Pressure Turbine (HPT) rotor blade from a modern aero-engine. 197 blades were measured using three-dimensional structured-light scanning (GOM scanning), and the performance of each blade is quantified using Reynolds-Averaged Navier-Stokes (RANS) simulations. Casting variation is typically managed by applying geometric tolerances to determine the suitability of a component for service. The analysis demonstrates that this approach may not be optimal since it does not necessarily align with performance, in particular the capacity and efficiency. Alternatively, functional acceptance based on the predicted performance of each blade removes the uncertainty associated with geometric tolerancing and gives better performance control. Building on these findings, the paper proposes a method to set the orientation of the fir-tree, which is machined after casting. By customizing the alignment of each blade, performance variability and scrap rates can be significantly reduced. The method uses predictions of performance to reorient the castings to compensate for the manufacturing-induced errors, without changing the design-intent blade geometry and with minimal changes to the manufacturing facility.
METAMATERIALS AND THE MATHEMATICAL SCIENCE OF INVISIBILITY (2013)

In this chapter, we review some recent developments in the field of\nphotonics: cloaking, whereby an object becomes invisible to an observer, and\nmirages, whereby an object looks like another one (say, of a different shape).\nSuch optical illusions are made possible thanks to the advent of metamaterials,\nwhich are new kinds of composites designed using the concept of\ntransformational optics. Theoretical concepts introduced here are illustrated\nby finite element computations.\n
Synchronised dual-wavelength mode-locking in waveguide lasers (2018)

We present a novel approach to study continuous-wave mode-locking in a waveguide laser in the presence of a gain profile with complex features. We introduce a new simulation approach where we separate the role of gain, nonlinearity, dispersion and saturable absorption elements to provide a better understanding of the interplay between these elements. In particular, we use the simulation to explain synchronised dual-wavelength mode-locking. The results show that despite the existence of dispersion which tends to form separate pulse trains in the laser cavity, the saturable absorber plays a critical role in keeping the different wavelength components synchronised. This work, for the first time, provides insight into existing experimental results. It also demonstrates new methods for studying lasers, especially mode-locking laser, with short laser cavities.
Intravascular low‐power laser irradiation after coronary stenting: Long‐term follow‐up (2001)

Intravascular red light therapy is safe, feasible, and reduces expected restenosis rate after coronary stenting.
Mobilization of peripheral blood progenitor cells for allogeneic transplantation: efficacy and toxicity of a high-dose rhG-CSF regimen. (1996)

Mobilization of PBPC was investigated in 19 healthy matched sibling donors using two different rhG-CSF regimens. Five donors (median age 39 years, range 17 to 57 years) received 10 micrograms rhG-CSF/kg bw once daily subcutaneously (s.c.), while 14 donors (median age 34 years, range 19 to 56 years) were treated with 10-12 micrograms rhG-CSF/kg bw twice daily s.c.. Leukapheresis was started on day 4 of rhG-CSF administration. Cytokine priming as well as collection of PBPCs were well tolerated. Application of twice daily rhG-CSF resulted in a higher yield of CD34+ cells in leukapheresis products than injection of once daily rhG-CSF. This high-dose twice daily rhG-CSF regimen is well tolerated and results in reliably high numbers of progenitor cells in the leukapheresis product in healthy donors, therefore collection as well as subsequent selection has been facilitated.