gebhart/patrepeval huggingface dataset:
Mobility self-optimization in LTE networks based on adaptive control theory (2013)

Mobility self-optimization is quite important for LTE networks, which depends on Mobility Robustness Optimization (MRO) and Mobility Load Balancing (MLB). The key performances of mobility, such as handover failure ratio, handover ping-pong ratio, and call-drop ratio are controlled by configurable cell parameters (TTT, Hyst and Ocs). In this paper, a control-theory based approach for tuning the cell parameters is proposed. MRO and MLB functions are jointly optimized in terms of control channels and their negative interaction is eliminated by the introduction of cross-links. Simulation results show that the proposed scheme outperforms existing approaches.
Secondary Amine Analogs of 3.beta.-(4'-Substituted phenyl)tropane-2.beta.-carboxylic Acid Esters and N-Norcocaine Exhibit Enhanced Affinity for Serotonin and Norepinephrine Transporters (1994)

N-Norcocaine (2) and six N-nor-3 beta-(4'-substituted phenyl)tropane-2 beta-carboxylic acid esters (4a-f) were synthesized by N-demethylation of cocaine (1) and the appropriate 3 beta-(substituted phenyl)-tropane analogues (3a-f) with alpha-chloroethyl chloroformate. Radioligand binding affinities of 2 and 4a-f at the DA, 5-HT, and NE transporter were measured and compared to those of 1 and 3a-f. N-Demethylation produced relatively small effects at the DA transporter. In contrast, 4-19-fold and 2-44-fold enhanced affinity at the serotonin and norepinephrine transporter resulted from demethylation. N-Nor-3 beta-(4'-iodophenyl)tropane-2 beta-carboxylic acid methyl ester (4d) with an IC50 = 0.36 nM showed the greatest affinity for the serotonin transporter. However, N-nor-3 beta-(4'-ethylphenyl)tropane-2 beta-carboxylic acid methyl ester (4e) showed the greatest selectivity for the serotonin transporter.
FizzX: Multiplayer time manipulation in networked games (2009)

We present a first attempt at designing and implementing distributed time manipulation in multiplayer networked games.
Figure S7 from A CS1-NKG2D Bispecific Antibody Collectively Activates Cytolytic Immune Cells against Multiple Myeloma (2023)

&lt;p&gt;A MM NSG mouse model bearing the H929 cell line with the intermediate level of CS1 expression was used to evaluate the anti-MM effect of the CS1-NKG2D biAb&lt;/p&gt;
Analytic Modeling of Vehicle Fuel Consumption (2013)

An analytical method of evaluating vehicle fuel consumption under standard operating conditions is presented. In the proposed model, vehicle fuel consumption is separated into two different operating modes: cruising at constant speed and acceleration. In each of these modes fuel consumption is calculated based on the instantaneous engine efficiency, approximated using an analytical function rather than typically considered consumption map. The approximation is based on speed-power decoupling, employing two single dimension polynomials instead of a two-dimensional lookup table. The adequacy and accuracy of the model is verified using experimental calculations. Moreover, it is shown that the effect of various design parameters on vehicle fuel consumption can be studied utilizing the proposed model.
Immunological Variables Mediate Cognitive Dysfunction in Gulf War Veterans but Not Civilians with Chronic Fatigue Syndrome (2002)

We explored the relationship between a set of immunological variables and a set of cognitive and functional status measures and a diagnosis of chronic fatigue syndrome (CFS) in civilians and veterans using various regression and factor analytic methods. Our approach emphasized the extraction of a few distinct factors in order to limit statistical problems associated with doing large numbers of multiple comparisons. This approach led to our finding cytokine data grouping into type 1 and type 2 clusters. A type 2 cluster plus a T and B cell factor predicted CFS caseness for Gulf War veterans but not for civilians with CFS. When a cognitive variable, reaction time, was added into the model, both immunological factors lost statistical significance; this indicates that the cognitive variable reaction time moderated the effects of the immunological factors in predicting patient status. We did a similar analysis on the roles of the immunological and cognitive variables in functional status using SF-36 data. Higher levels of these same two immunological factors predicted poorer general health as well as poorer physical and social functioning in Gulf War veterans but not in civilians with CFS. When the reaction time factor was added, only the lymphocyte factor remained significant. This implies that lymphocytes are directly related to functional status in Gulf War veterans with CFS, but the Th2 factor produces its effect on functional status via changes in cognitive abilities.
Speeding up seismic image segmentation (2010)

Seismic images of the subsurface are often very large and tedious to interpret manually; as such, automatic segmentation algorithms can be highly useful for tasks such as locating large, irregularly shaped salt bodies within the images. However, seismic images present unique challenges for image segmentation algorithms. Here, a new graph‐based segmentation algorithm using a “pairwise region comparison” strategy is implemented and tested on seismic images. Numerous modifications to the original algorithm are necessary to make it appropriate for use with seismic data, including changes to the nature of the input data, the way in which the graph is constructed, and the formula for calculating edge weights. Initial results indicate that the new method compares very favorably with an existing implementation of the eigenvector‐based normalized cuts approach, both in terms of accuracy and efficiency. With further improvement, this method could become a useful and powerful tool for processing and interpreting seismic images.
Neurologic examination abnormalities in schizophrenia with and without a history of alcoholism. (2000)

A history of alcoholism in SZ is associated with greater overall neurologic impairment, particularly in the area of cognitive-perceptual dysfunction, an area often found to be impaired in patients with schizophrenia without alcoholism.
Achievable Rates of Underwater Acoustic OFDM Systems over Highly Dispersive Channels (2012)

Unlike the capacity of other channels, the capacity of the shallow water UAC channel has been seldomly addressed. Motivated by recent results in information theory, this paper investigates achievable rates of underwater acoustic OFDM systems. We consider channels where time and frequency dispersion is high enough that (i) neither the transmitter nor the receiver can have a priori knowledge of the channel state information, and (ii) intersymbol/intercarrier interference (ISI/ICI) cannot be neglected in the information theoretic treatment.
Human T-lymphocyte subset specificity of the regulatory effects of leukotriene B4. (1984)

Leukotriene B4, but not (12S)-leukotriene B4, coupled to fluorescein-labeled human serum albumin interacts specifically with human T lymphocytes, as assessed by fluorescence-activated flow cytometry. Approximately 11% of blood T lymphocytes bind the fluorescent conjugate of leukotriene B4. The leukotriene B4-reactive T lymphocytes are distributed between the suppressor-cytotoxic (14%) and helper-inducer (8%) subsets, which were identified concurrently by phycoerythrin-labeled monoclonal antibodies to subset-specific antigens. Leukotriene B4, but not (12S)-leukotriene B4 or leukotriene C4, enhances significantly the proliferation of mitogen-stimulated purified suppressor-cytotoxic T lymphocytes, at concentrations of 10(-12) M to 10(-6) M, and inhibits significantly the proliferation of mitogen-stimulated purified helper-inducer T lymphocytes, at concentrations of 10(-8) M to 10(-6) M, as assessed by the uptake of [3H]thymidine. The net effect of leukotriene B4 on blood T lymphocytes is immunosuppression, which may be expressed in some human hypersensitivity and inflammatory diseases.
Poor progress in labour (2014)

Abstract Poor progress in labour is associated with increased maternal morbidity and mortality. Prolonged labour can predispose to maternal dehydration, sepsis, and ketoacidosis and increase the risk of PPH, obstetric fistulae, obstruction, uterine rupture, stillbirth, and maternal death. There is also an increase in Caesarean section rates for dystocia and failure to progress, with its attendant risks for both the mother and the baby. Systematic evidence-based management of poor progress in labour can prevent adverse obstetric outcomes.
On simplifying the primal-dual method of multipliers (2016)

Recently, the primal-dual method of multipliers (PDMM) has been proposed to solve a convex optimization problem defined over a general graph. In this paper, we consider simplifying PDMM for a subclass of the convex optimization problems. This subclass includes the consensus problem as a special form. By using algebra, we show that the update expressions of PDMM can be simplified significantly. We then evaluate PDMM for training a support vector machine (SVM). The experimental results indicate that PDMM converges considerably faster than the alternating direction method of multipliers (ADMM).
Revealing the Molecular-Level Interactions between Cationic Fluorinated Polymer Sorbents and the Major PFAS Pollutant PFOA (2022)

The development of new technologies for the removal of a family of manufactured chemicals, the per- and polyfluoroalkyl substances (PFAS), from the environment is urgently needed to safeguard public and environmental health. Here we report a fundamental study of the binding mechanisms driven by fluorine–fluorine and electrostatic interactions between perfluorooctanoic acid (PFOA), an important PFAS molecule, and three types of block copolymer sorbents containing individually perfluoropolyether (PFPE) or quaternized ammonium groups, or both functional segments in combination. The results show that both the fluorine–fluorine interactions between the PFPE segment of the block copolymer and the fluorinated tail of the PFOA as well as electrostatic attraction between the quaternized ammonium group and the anionic PFOA headgroup are crucial to achieve effective PFOA sorption from aqueous solutions. The fluorine–fluorine interactions contribute to recognition of PFOA molecules via fluorophilicity, with fast exchange between bound and free PFOA being observed, while the electrostatic interactions can tightly bind PFOA, thus precluding such exchange. Both types of interaction are observed to be rapidly established within 5 min. We show that the sorbents containing both fluorinated and cationic groups have a higher PFOA removal efficiency with potentially improved sorption capacity compared with the sorbents with a single functional group and that the electrostatic attraction is stronger and dominates the fluorine–fluorine interactions when the sorbent is highly charged. Overall, these results provide important insights into designing novel sorbents for rapid and efficient PFAS removal from contaminated environments.
Metallurgical and Stress State Factors Which Affect the Creep and Fracture Behavior of 9% Cr Steels (2018)

EPRI‐supported research has identified critical material information regarding the factors affecting the performance of creep strength‐enhanced ferritic steels, in general, and Grade 91 steel, in particular. EPRI recommendations emphasize that a five‐point, integrated strategy should be used for the effective life management of components fabricated from tempered martensitic steels. This integration promotes a balanced use of resources which, when properly focused, reduces uncertainty regarding creep and fracture behavior. Tighter control of processes from steel making, steel processing, and heat treatment ensures that alloys with deficient properties never enter service. One cornerstone of this proactive approach is the definition of ‘Metallurgical Risk’ which links the presence of inclusions and trace elements to the susceptibility for creep damage. The improved confidence in the high temperature performance of CSEF steel components promotes reliability, increases efficiency, and minimizes the risk of component fracture.
Polarization-selective computer-generated holograms (1993)

We demonstrate polarization-selective computer-generated holograms with independent phase profiles for the two orthogonal linear polarizations. The holograms are made of two surface-relief-etched birefringent substrates joined face to face. We describe their design and fabrication and present experimental results for dual binary-phase computer-generated holograms fabricated in lithium niobate. The first-order diffraction efficiency varied from 6% to 25%, with as much as 40:1 contrast between polarizations. Such elements can be used in compact optoelectronic systems or combined with electro-optic polarization rotators to make electrically controlled optical elements.
Bacteroides thetaiotaomicron: a dynamic, niche‐adapted human symbiont (2003)

The coevolution of humans with their intestinal microflora has resulted in cooperative relationships that have shaped the biology and the genomes of these symbiotic partners. Bacteroides thetaiotaomicron is one such bacterial symbiont that is a dominant member of the intestinal microbiota of humans and other mammals. The recent report of the genome sequence of B. thetaiotaomicron is the first reported for an abundant Gram-negative organism of the human colonic microbiota and, as such, provides the first glimpse on a genomic scale of the genetic arsenal used by a Gram-negative symbiont to dominate in this ecosystem. The genome has revealed large expansions of many paralogous groups of genes that encode products essential to the organism's ability to successfully compete in this environment. Most noteable is the organism's abundant machinery for utilizing a large variety of complex polysaccharides as a source of carbon and energy. The proteome also reveals the organism's extensive ability to adapt and regulate expression of its genes in response to the changing ecosystem. These factors, as well as others highlighted below, suggest an incredibly flexible and adaptable organism that is exquisitely equipped to dominate in its challenging and competitive niche.
Metabolites of the Pyrimidine Amine Preladenant as Adenosine A2a Receptor Antagonists (2012)

ADVERTISEMENT RETURN TO ISSUEPREVPatent HighlightNEXTMetabolites of the Pyrimidine Amine Preladenant as Adenosine A2a Receptor AntagonistsGerard Rosse*View Author Information Structure Guided Chemistry, Dart Neuroscience LLC, 7473 Lusk Boulevard, San Diego, California 92121, United States Adjunct Associate Professor, Department of Pharmacology and Physiology, Drexel University, College of Medicine, New College Building, 245 N. 15th Street, Philadelphia, Pennsylvania 19102*E-mail: [email protected]Cite this: ACS Med. Chem. Lett. 2013, 4, 1, 5–6Publication Date (Web):November 30, 2012Publication History Received15 November 2012Published online30 November 2012Published inissue 10 January 2013https://pubs.acs.org/doi/10.1021/ml300397jhttps://doi.org/10.1021/ml300397jeditorialACS PublicationsCopyright © 2012 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1089Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (230 KB) Get e-AlertscloseSUBJECTS:Antagonists,Assays,Metabolism,Nucleic acids,Receptors Get e-Alerts
Effects of ractopamine, genotype, and growth phase on finishing performance and carcass value in swine: I. Growth performance and carcass merit (1991)

A replicated factorial experiment using 183 individually fed crossbred barrows was conducted. Pigs were fed an 18.5% CP (.95% lysine) diet with 3,594 kcal of ME/kg. The effects of five genotypes (GT): 1) Hampshire (H) x (H x Duroc [D]), 2) synthetic terminal sire line, 3) (H x D) x (Landrace [L] x [Yorkshire (Y) x D]), 4) L x (Y x D), and 5) Y x L; two levels of ractopamine (RAC) treatment: 0 and 20 ppm; and three treatment weight periods (WT): 1) 59 to 100, 2) 73 to 114, and 3) 86 to 127 kg live weight on growth performance and carcass traits were evaluated. Ractopamine increased (P less than .0001) amount (FSL) and percentage (PFSL) of carcass lean standardized to 10% fat content, loin eye area (LEA), and dressing percentage (PDRES) and reduced (P less than .01) amount (DF) and percentage (PDF) of dissected fat. Magnitudes of RAC effects were smaller than those reported by other researchers. Effects of GT and WT on all growth and carcass traits were highly significant (P less than .001) except for those of WT on ADG (P less than .05) and GT on average feed intake (AFI) and backfat thickness at the last rib (BFLR; P less than .05). Genotype 3 performed better for most economically important traits than did GT 1 and 4, suggesting that heterosis existed in GT 3, which essentially was obtained by crossing GT 1 and 4. Among the three treatment periods, WT 2 had the highest ADG. As BW increased from WT 1 to 3, AFI and AFI/ADG ratio (FCR) increased and lean percentage decreased.(ABSTRACT TRUNCATED AT 250 WORDS)
Solid Optics: The Application Of Precision Manufacturing To Small, Complex Optical Systems (1987)

A variety of approaches have been proposed in recent years for construction of Solid Optics. After a brief review of the goals and history, we describe a new, systematic approach. The new approach involves the total removal of air gaps from the system. This requires &quot;solid air&quot; for light propagation. Solid air, in turn, behaves differently from the more familiar air. In particular, it has a larger index of refraction and more dispersion. Modular, highly manufacturable systems approaches are described.
Therapeutic Targeting of MYC and HIF Networks in Cancer (2009)

The MYC oncogene is involved in many human cancers, which in general develop under limited amount of oxygen (hypoxia) requiring the activity of hypoxia inducible factors (HIFs). The interaction of MYC, which encodes a transcription factor Myc, with HIF under physiological conditions provides insights into normal cellular responses to hypoxia via cell growth arrest and anaerobic glycolysis. Many tumors contain genetic alterations, such as MYC activation, that can collaborate with HIF to confer metabolic advantages to tumor cells, which tend to exist in a hypoxic microenvironment. The collaboration of oncogenic Myc with HIF favors the conversion of glucose to lactate which could be exploited for therapeutic purposes. This article reviews the transcriptional network operative in a tumorigenic milieu and therapeutic opportunities within the Myc and HIF network of target genes.
&lt;title&gt;Multiple-Frequency Heterodyne Correlation Radiometry&lt;/title&gt; (1976)

A heterodyne correlation radiometer is proposed for the sensitive detection of radiating species whose Doppler shift is known, but whose presence we wish to affirm. Such radiation (which may be actively induced) can arise, for example, from remote molecular emitters, impurities and pollutants, trace minerals, chemical agents, or a general multiline source. A radiating sample of the species to be detected is physically made a part of the laboratory receiver, and serves as a kind of frequency-domain template with which the remote radiation is correlated, after heterodyne detection. The system is expected to be especially useful for the detection of sources whose radiated energy is distributed over a large number of lines, with frequencies that are not necessarily known. Neither a stable nor a tunable local oscillator is required. It is shown that the minimum detectable power is expressible in a form similar to that for conventional heterodyning (for both quantum-noise-limited and Johnson-noise-limited detectors). The notable distinction is that the performance of the proposed system improves with increasing number of remotely radiating signal lines and increasing locally produced radiation power. Performance degradation due to undesired impurity radiation is considered and shown not to be a problem in general. The technique should be applicable over a broad frequency range from the microwave to the optical, with its most likely use in the infrared.
Microwave microfluidic sensor for determination of glucose concentration in water (2015)

In this paper, a compact microfluidic biosensor is designed based on a complementary electric-LC resonator coupled with a microstrip line. It is shown that by flowing water-glucose solutions with different concentrations to the sensing area, the resonance property of the resonator is modified. This measurable change in the electromagnetic property is then used to quantify the glucose concentration. A prototype of the designed sensor is fabricated and tested to verify the biosensing concept.
The Auxiliary Subunits Neto1 and Neto2 Reduce Voltage-Dependent Inhibition of Recombinant Kainate Receptors (2012)

Kainate receptors can be subject to voltage-dependent block by intracellular polyamines, which causes inward rectification of the current-voltage relationship. Sensitivity to polyamine block is largely determined by the identity of a residue within the pore domain that can be altered through RNA editing. This process causes replacement of the encoded glutamine(Q) with a positively charged arginine(R), eliminating polyamine inhibition and thus inward rectification. In neurons, kainate receptors can associate with the auxiliary subunits Neto1 or Neto2. These transmembrane proteins alter the trafficking, channel kinetics, and pharmacology of the receptors in a subunit-dependent manner. We found that coexpression of Neto subunits with recombinant GluK2(Q) kainate receptors greatly reduced inward rectification without altering calcium permeability. This effect was separate from modulation of channel kinetics, as mutations within the extracellular LDLa domain of the Neto proteins completely eliminated their effects on desensitization but only reduced their effects on rectification. Conversely, deletion of the intracellular C-terminal domain of Neto1 or Neto2 or neutralization of positively charged residues within this domain prevented the reduction in rectification but did not alter effects on channel kinetics. These results demonstrate new roles for Neto1 and Neto2 in regulating kainate receptor function and identify domains within these auxiliary subunits important for mediating their effects.
Taut Internal Limiting Membrane Causing Diffuse Diabetic Macular Edema after Vitrectomy: Clinicopathological Correlation (2011)

A taut ILM can cause diffuse DME after vitrectomy, and its removal can restore the normal foveal contour and improve visual acuity. Tangential tractional forces from contractile cells propagated across the fovea via the ILM appear to be the etiology.