gebhart/patrepeval huggingface dataset:
Timeline of COVID-19 Incidence and Mortality among Residents and Staff of South Carolina Long-term Care Facilities (2021)

Abstract The COVID-19 pandemic has disproportionately impacted older adults living in long-term care facilities (LTCFs), but little research has described parallel infection rates and mortality among LTCF residents and staff in relation to state-level mitigation measures. This study used comprehensive COVID-19 tracking data from the South Carolina Department of Health and Environmental Control (SCDHEC), including case report information on demographics, symptoms, comorbidities, and employment. We included all confirmed or probable COVID-19 cases and deaths among adult SC residents reported between 3/15/2020 and 1/2/2021. Residence or employment in LTCF, including nursing homes, assisted living, or skilled nursing facilities, were confirmed by SCDHEC. Cox proportional hazards models were used to compare mortality between residents/staff and counterparts in the community. Overall, 54,514 cases of COVID-19 were identified among older adults in SC. Of these, 13.5% (n = 7,366) resided in a LTCF. LTCF residents with COVID-19 were more likely to be hospitalized compared to older adults in the community and 74% more likely to die (HR= 1.74, 95% CI: 1.59-1.90), after controlling for age, gender, race, and chronic health conditions. LTCF staff had greater infection rates but lower risk of mortality (HR=0.58; 95% CI: 0.39-0.88) compared to the general population. Differences in COVID-19 incidence and mortality between residents/staff and the community decreased after statewide mitigation policies. This study indicates that LTCF residents are at increased risk of COVID infection and mortality, even accounting for pre-existing health conditions. LTCF settings are key sites for prioritizing prevention, vaccination, and training plans to prepare for future pandemics.
Suppression of Read Disturb Fail Caused by Boosting Hot Carrier Injection Effect for 3-D Stack NAND Flash Memories (2014)

A new bias pulse method was proposed to suppress read disturbance in unselected strings of 3-D stack NAND flash memories. Using the proposed read method, we could suppress effectively a large cell Vth shift generated by boosting hot carrier injection. As a result, the cell Vth shift in unselected string is quite similar to normal read disturbance in select string. The proposed read method was verified by both measurement and simulation.
Enhanced Light-Extraction from InGaN Quantum Wells using Refractive-Index-Matched TiO2. (2020)

Abstract not provided.
Analyses of gonococcal H8 antigen. Surface location, inter- and intrastrain electrophoretic heterogeneity, and unusual two-dimensional electrophoretic characteristics. (1985)

The H8 protein is a surface-exposed antigen that is found, among members of the Neisseria genus, primarily on pathogenic species. In this study, the surface exposure of H8 was reassessed by four techniques. Results of slide agglutination, indirect fluorescent antibody binding, absorption of sera with whole gonococci, and immune electron microscopy all confirmed the presence of H8 in the outer membrane. The degree to which protein A-gold-labeled monoclonal antibodies bound to H8 was marked, and suggested that this antigen was present in abundant amounts in the outer membrane. Also in this study, the electrophoretic heterogeneity of this common surface antigen was examined. Because H8 stains poorly, electrophoretic mobility was assessed using polyclonal antibodies and a monoclonal antibody that recognizes a common H8 epitope. H8 was analyzed with respect to protein I, lipopolysaccharide (LPS), and pilus and opacity phenotypic variation; results confirmed that heterogeneity of Mr was the rule among strains (21 were examined), however, the variability in Mr was independent of protein I or LPS Mr. In one strain (FA1090), the heterogeneity of H8 was examined among 10 piliation/opacity variants; the H8 (and LPS) Mr was identical in all variants; similar data were generated in strains JS3 and JS1. The electrophoretic mobility of H8 was altered in serum-resistant and neutrophil enzyme-resistant gonococci compared to the sensitive gonococci. Some of the unusual electrophoretic migration characteristics of the antigen were also examined. H8 formed a unique mushroom-shaped band in one-dimensional gels; in a two-dimensional electrophoresis system, the antigen migrated aberrantly, very similarly to LPS. Also seen in the two-dimensional electrophoresis profile were multimers of the H8 antigen; in strain JS3 (Mr 23,500), these migrated at 43,600, 86,000, and greater than 150,000. In other strains, the Mr of the multimers differed depending upon the Mr of the monomer. The two-dimensional migration characteristics (as measured by antigenicity) were completely destroyed by proteinase K digestion. Activity of H8 polyclonal antibodies to the antigens in two-dimensional gels was completely removed by adsorption of formalin-fixed whole cells, but was not affected by adsorption with LPS. These electrophoretic characteristics may reflect the close association of some nonprotein constituent, perhaps lipid or carbohydrate or both.
Automatic extraction of the arterial tree from 3-D angiograms (2003)

A more efficient automated method is described for extracting the coronary arterial tree from a 3-D dynamic spatial reconstructor (DSR) angiogram. The method, its advantages, and the results of a 3-D arterial, tree extraction are discussed. The advantages of the method are that it requires only a few minutes of operator time to analyze a volume, the results are exactly reproducible, given the parameter values, and the algorithm works in three dimensions.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Synthesis and Pharmacological Activities of Pyrazole Derivatives: A Review (2018)

Pyrazole and its derivatives are considered a pharmacologically important active scaffold that possesses almost all types of pharmacological activities. The presence of this nucleus in pharmacological agents of diverse therapeutic categories such as celecoxib, a potent anti-inflammatory, the antipsychotic CDPPB, the anti-obesity drug rimonabant, difenamizole, an analgesic, betazole, a H2-receptor agonist and the antidepressant agent fezolamide have proved the pharmacological potential of the pyrazole moiety. Owing to this diversity in the biological field, this nucleus has attracted the attention of many researchers to study its skeleton chemically and biologically. This review highlights the different synthesis methods and the pharmacological properties of pyrazole derivatives. Studies on the synthesis and biological activity of pyrazole derivatives developed by many scientists around the globe are reported.
Effects of para-substituents on the mechanisms of solvolysis of styrene oxides (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEffects of para-substituents on the mechanisms of solvolysis of styrene oxidesJeffrey J. Blumenstein, Victoria C. Ukachukwu, Ram S. Mohan, and Dale L. WhalenCite this: J. Org. Chem. 1993, 58, 4, 924–932Publication Date (Print):February 1, 1993Publication History Published online1 May 2002Published inissue 1 February 1993https://doi.org/10.1021/jo00056a027Request reuse permissionsArticle Views474Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-Alertsclose Get e-Alerts
Soft-magnetic rotational microwings in an alternating magnetic field applicable to microflight mechanisms (2003)

This paper presents microsized soft-magnetic rotational wings in an alternating magnetic field. The wireless power supply as well as control of magnetic microwings are readily applicable to microflight mechanisms. As a magnetic material, soft magnetic material, such as nickel-iron alloy was deposited via electroplating, which is a well-developed MEMS batch process. The magnetization of the soft-magnetic device, however, changes its direction and magnitude during rotation, where the shape magnetic anisotropy of the wings plays a vital role. The principle of the wing rotation in an alternating magnetic field was elucidated theoretically and showed favorable agreement with the experimental results with large-sized models. The aerodynamic performances of soft magnetic rotational wings were evaluated, including the microrotational wings 165 μg in weight consisting of 0.9-mm-long magnetic wings made of electroplated nickel-iron alloy and an axis of wing rotation made of a sharpened glass tube. The micromagnetic rotational wings presented here were utilized for microflight mechanisms, which achieved successful flights.
Secure Node Discovery in Ad-hoc Networks and Applications (2007)

Designing secure protocols over ad-hoc networks has proved to be a very challenging task, due to various features of such networks, such as partial connectivity, node mobility, and resource constraints. Furthermore, their lack of physical infrastructures deprives their users of even basic network functions such as message routing, for which nodes are themselves responsible. In this paper we consider a very basic network function, node discovery, in ad-hoc networks, where a node with limited network information would like to establish a session with a given number of other nodes in the network (of which the node may not be aware about). We formally define correctness, security and efficiency properties of node discovery protocols, and investigate the problem of designing such protocols under appropriate network topology assumptions. Here, the security of these protocols is against Byzantine adversaries that can corrupt up to a limited number of nodes in the network and make them arbitrarily deviate from their protocol. After presenting some secure node discovery protocols, we show their application to secure service architectures in ad-hoc networks.
Fig Supp 2 from HDAC6 Plays a Noncanonical Role in the Regulation of Antitumor Immune Responses, Dissemination, and Invasiveness of Breast Cancer (2023)

&lt;p&gt;Fig Supp 2&lt;/p&gt;
SOCS3 Silencing Attenuates Eosinophil Functions in Asthma Patients (2015)

Eosinophils are one of the key inflammatory cells in asthma. Eosinophils can exert a wide variety of actions through expression and secretion of multiple molecules. Previously, we have demonstrated that eosinophils purified from peripheral blood from asthma patients express high levels of suppressor of cytokine signaling 3 (SOCS3). In this article, SOCS3 gene silencing in eosinophils from asthmatics has been carried out to achieve a better understanding of the suppressor function in eosinophils. SOCS3 siRNA treatment drastically reduced SOCS3 expression in eosinophils, leading to an inhibition of the regulatory transcription factors GATA-3 and FoxP3, also interleukin (IL)-10; in turn, an increased STAT3 phosphorilation was observed. Moreover, SOCS3 abrogation in eosinophils produced impaired migration, adhesion and degranulation. Therefore, SOCS3 might be regarded as an important regulator implicated in eosinophil mobilization from the bone marrow to the lungs during the asthmatic process.
Fusion of WLAN and GNSS observables for positioning in urban areas: The position ambiguity (2011)

This paper proposes a positioning method that combines GPS pseudoranges and WLAN ranges when less than four GPS satellites are within sight. To enhance the positioning availability, a tight hybridization approach with both technologies is considered. Although the work has been performed considering WLAN and GPS, most of the presented ideas, procedures and results are also valid for generic tight non-synchronized fusion of GNSS with terrestrial signals. Special emphasis is placed on the phenomenon of positioning ambiguity that appears due to the combination of measurements with different characteristics. To solve this ambiguity, a method is proposed and studied. The availability and accuracy of the system are tested considering different satellite and terrestrial geometries. The results show that the proposed system is able to improve the availability while maintaining the accuracy of GPS as a standalone.
Dual-pump push-pull polarization control using stimulated Brillouin scattering (2011)

Stimulated Brillouin scattering (SBS) amplification of probe signals is highly polarization dependent. Maximum and minimum gain values are associated with a pair of orthogonal states of polarization (SOP), which are related to the pump SOP. Since the maximum gain is much higher than the minimum, the SOP of the output probe is pulled towards that of the maximum amplification. Polarization pulling is restricted, however, by pump depletion. In this work, a new method is proposed, analyzed and demonstrated for enhanced SBS polarization pulling, using two orthogonal pumps. Here, one pump amplifies one polarization component of the probe wave, and at the same time the other pump attenuates the corresponding orthogonal component, resulting in a push-pull effect. In the undepleted regime and for equal total power, the same degree of pulling is achieved as in the single pump case, but at a significantly less signal gain. Thus, the dual pump technique can provide high pulling efficiency for stronger input signals, deferring the onset of depletion.
A Gene Expression Classifier of Node-Positive Colorectal Cancer (2009)

We used digital long serial analysis of gene expression to discover gene expression differences between node-negative and node-positive colorectal tumors and developed a multigene classifier able to discriminate between these two tumor types. We prepared and sequenced long serial analysis of gene expression libraries from one node-negative and one node-positive colorectal tumor, sequenced to a depth of 26,060 unique tags, and identified 262 tags significantly differentially expressed between these two tumors (P < 2 x 10(-6)). We confirmed the tag-to-gene assignments and differential expression of 31 genes by quantitative real-time polymerase chain reaction, 12 of which were elevated in the node-positive tumor. We analyzed the expression levels of these 12 upregulated genes in a validation panel of 23 additional tumors and developed an optimized seven-gene logistic regression classifier. The classifier discriminated between node-negative and node-positive tumors with 86% sensitivity and 80% specificity. Receiver operating characteristic analysis of the classifier revealed an area under the curve of 0.86. Experimental manipulation of the function of one classification gene, Fibronectin, caused profound effects on invasion and migration of colorectal cancer cells in vitro. These results suggest that the development of node-positive colorectal cancer occurs in part through elevated epithelial FN1 expression and suggest novel strategies for the diagnosis and treatment of advanced disease.
Multiresolution detection of coherent radar targets (2002)

Examines the problem of detecting a known target in clutter and shows that a multiresolution-based detector significantly outperforms a more conventional single-resolution detector. The authors then apply a sampling strategy that allows one to choose, for each fixed n, those n resolutions that maximize detection performance. This optimal multiresolution sampling strategy suggests that wavelet or wavelet packet decompositions which typically use dyadic or triadic resolution splits are not necessarily optimal bases for coherent radar signature representation.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
ChemInform Abstract: Substituent Effects on 1,3‐Dipolar Cycloadditions to Some 1,1‐Diphenyl‐ 2‐aza‐1,3‐butadiene Derivatives. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
PowerBEV: A Powerful Yet Lightweight Framework for Instance Prediction in Bird’s-Eye View (2023)

Accurately perceiving instances and predicting their future motion are key tasks for autonomous vehicles, enabling them to navigate safely in complex urban traffic. While bird’s-eye view (BEV) representations are commonplace in perception for autonomous driving, their potential in a motion prediction setting is less explored. Existing approaches for BEV instance prediction from surround cameras rely on a multi-task auto-regressive setup coupled with complex post-processing to predict future instances in a spatio-temporally consistent manner. In this paper, we depart from this paradigm and propose an efficient novel end-to-end framework named PowerBEV, which differs in several design choices aimed at reducing the inherent redundancy in previous methods. First, rather than predicting the future in an auto-regressive fashion, PowerBEV uses a parallel, multi-scale module built from lightweight 2D convolutional networks. Second, we show that segmentation and centripetal backward flow are sufficient for prediction, simplifying previous multi-task objectives by eliminating redundant output modalities. Building on this output representation, we propose a simple, flow warping-based post-processing approach which produces more stable instance associations across time. Through this lightweight yet powerful design, PowerBEV outperforms state-of-the-art baselines on the NuScenes Dataset and poses an alternative paradigm for BEV instance prediction. We made our code publicly available at: https://github.com/EdwardLeeLPZ/PowerBEV.
21 Svenska fondförvaltares prestation mot index OMX30 (2015)

The purpose of this study is to examine the performance of 21 Swedish funds in relation to the OMXS30. We use two measures of performance: the CAPM model and Jensen's ALPHA. Our results suggest tha ...
Diversity and Chemical Library Networks of Large Data Sets (2021)

The quantification of chemical diversity has many applications in drug discovery, organic chemistry, food, and natural product chemistry, to name a few. As the size of the chemical space is expanding rapidly, it is imperative to develop efficient methods to quantify the diversity of large and ultralarge chemical libraries and visualize their mutual relationships in chemical space. Herein, we show an application of our recently introduced extended similarity indices to measure the fingerprint-based diversity of 19 chemical libraries typically used in drug discovery and natural products research with over 18 million compounds. Based on this concept, we introduce the Chemical Library Networks (CLNs) as a general and efficient framework to represent visually the chemical space of large chemical libraries providing a global perspective of the relation between the libraries. For the 19 compound libraries explored in this work, it was found that the (extended) Tanimoto index offers the best description of extended similarity in combination with RDKit fingerprints. CLNs are general and can be explored with any structure representation and similarity coefficient for large chemical libraries.
TopicCheck: Interactive Alignment for Assessing Topic Model Stability (2015)

Jason Chuang, Margaret E. Roberts, Brandon M. Stewart, Rebecca Weiss, Dustin Tingley, Justin Grimmer, Jeffrey Heer. Proceedings of the 2015 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies. 2015.
Quantification of peak shaving capacity in electric vehicle charging – findings from case studies in Helsinki Region (2020)

An increasing share of electric vehicles can mean excessive peak loads in low‐voltage power distribution networks. Introducing peak shaving mechanisms to the charging systems, such overloads can be mitigated significantly. The first contribution of this study is to quantify the amount of flexibility that electric vehicles can contribute to peak load reduction so that the drivers can still fully charge the batteries of their vehicles. The second contribution is that the study presents and compares two optimisation strategies for peak load reduction. The work is based on real charging data covering about 25,000 charging sessions at various charging sites in the metropolitan area of the Finnish capital city. The main finding is that the peak loads at charging sites can be reduced by up to 55%. Another important result is that load reduction through low‐power charging is achievable only if the average parking time at the charging site is &gt;3 h, without affecting the user experience negatively. It is also found out that the average parking time is over 2 h longer than the average charging time, which indicates the enormous potential of electric vehicles in peak shaving.
Combined analysis of transcriptome and metabolite data reveals extensive differences between black and brown nearly-isogenic soybean (Glycine max) seed coats enabling the identification of pigment isogenes (2011)

Metabolite composition and gene expression differences between black (iRT) and brown (irT) seed coats are far more extensive than previously thought. Putative anthocyanin, proanthocyanidin, (iso)flavonoid, and phenylpropanoid isogenes were differentially-expressed between black (iRT) and brown (irT) seed coats, and UGT78K2 and OMT5 were validated to code UDP-glycose:flavonoid-3-O-glycosyltransferase and anthocyanin 3'-O-methyltransferase proteins in vitro, respectively. Duplicate gene copies for several enzymes were overexpressed in the black (iRT) seed coat suggesting more than one isogene may have to be silenced to engineer seed coat color using RNA interference.
Figure S1 from IL15 Infusion of Cancer Patients Expands the Subpopulation of Cytotoxic CD56&lt;sup&gt;bright&lt;/sup&gt; NK Cells and Increases NK-Cell Cytokine Release Capabilities (2023)

&lt;p&gt;Differentiation from CD56 bright to CD56 dim /CD94 high to CD56 dim /CD94 low NK cells is accompanied by increasing requirements for IL-15 to induce their proliferation. Various NK cell subsets were sorted from PBMCs of normal donors, CFSE-labeled, cultured for 7 days, and their CFSE dilu- tion as a measure of proliferation was determined by FACS.&lt;/p&gt;