gebhart/patrepeval huggingface dataset:
Potassium alkoxide promoted 1,3 shifts of dithianes (1978)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPotassium alkoxide promoted 1,3 shifts of dithianesStephen R. Wilson and Raj N. MisraCite this: J. Org. Chem. 1978, 43, 25, 4903–4905Publication Date (Print):December 1, 1978Publication History Published online1 May 2002Published inissue 1 December 1978https://pubs.acs.org/doi/10.1021/jo00419a051https://doi.org/10.1021/jo00419a051research-articleACS PublicationsRequest reuse permissionsArticle Views103Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Case Report: COVID-19 Infection and Cervical Artery Dissection (2022)

A 45-year-old woman presented 3 days after symptom resolution from a COVID-19 infection with a left vertebral artery dissection with no known preceding trauma or underlying disposition. She subsequently suffered a left lateral medullary stroke 15 hours after her initial presentation. Cervical artery dissections (CeAD) can occur in the absence of trauma, and in some cases, infection may be a contributing factor. COVID-19 infection can cause an endotheliopathy and inflammatory response, which may contribute to intimal vessel disruption. Whether COVID-19 infection can contribute to CeAD and subsequent stroke is discussed, along with other considerations regarding the pathogenesis of CeAD.
Differential immunological crossreactivity of HeLa keratin antibodies with human epidermal keratins. (1983)

HeLa cells contain four keratin-like proteins having molecular weights of 50,000 (IEF 31), 48,500 (IEF 36), 44,000 (IEF 44), and 43,500 (IEF 46), respectively. Mouse polyclonal antibodies prepared against two of these keratins (IEF 31 and 46) have been used in this study to identify human epidermal keratins with common antigenic determinants. Using a sensitive immunoprecipitation procedure we show that the IEF 31 antibody crossreacts with three human acidic epidermal keratins, termed K1, K2, and K3, having molecular weights of 44,000, 47,500, and 54,000, respectively. One of these keratins (K1) comigrated with HeLa keratin IEF 44 and exhibited an identical one-dimensional peptide map. This protein is also abundant in basaliomas. In contrast to these results, the IEF 46 antibody showed no crossreactivity with any of the human acidic or basic [35S]methionine-labeled epidermal proteins. The lack of crossreactivity of this antibody was further confirmed by indirect immunofluorescence staining of cryostat sections from human split skin. These results emphasize both the similarity and diversity of antigenic determinants among HeLa and epidermal keratins.
Effect of irrigation water pH and acidifying source on silvery-thread moss (Bryum argenteum Hedw.) establishment (2016)

Many bryophytes are intolerant of osmotic stresses; nevertheless, Bryum argenteum often spreads in golf course greens irrigated with water containing a moderate amount of sodium and/or bicarbonates. The ability of B. argenteum to survive in this stressful environment could be linked to the use of acid injection systems, which are often retrofitted to irrigation systems to combat the negative effects of these harmful salts. The objective of this study was to determine if altering the pH of sodic irrigation water using either sulfuric or hydrochloric acid affects the growth of B. argenteum. Secondarily, if growth of B. argenteum was affected, we sought to understand whether that effect was due to differences in nutrient uptake or availability under the different water pHs and/or acidifying sources. Phosphate buffer solutions (0.01 M, pH = 9) were titrated with each acid to obtain pHs 5, 6, 7 and 8. Irrigation solutions were applied daily to pots containing a sand substrate and nascent B. argenteum for 28 d. Acid source had no effect on moss cover, but pH significantly affected B. argenteum cover. Generally, pots irrigated with pHs 5 and 6 had six- to seven-fold increases in B. argenteum cover compared to pHs 7 and 8. Additionally, the shoot tissue of pots treated with pH 5 contained twice as much potassium compared to pots irrigated with pH 9. These results indicate the growth of B. argenteum increases when acid injection systems are used to amend sodic irrigation water.
Kinetic Mechanism of the Rtt109−Vps75 Histone Acetyltransferase−Chaperone Complex (2010)

Rtt109 is a histone acetyltransferase (HAT) involved in promoting genomic stability, DNA repair, and transcriptional regulation. Rtt109 associates with the NAP1 family histone chaperone Vps75 and stimulates histone acetylation. Here we explore the mechanism of histone acetylation and report a detailed kinetic investigation of the Rtt109-Vps75 complex. Rtt109 and Vps75 form a stable complex with nanomolar binding affinity (K(d) = 10 +/- 2 nM). Steady-state kinetic analysis reveals evidence of a sequential kinetic mechanism whereby the Rtt109-Vps75 complex, AcCoA, and histone H3 substrates form a complex prior to chemical catalysis. Product inhibition studies demonstrate that CoA binds competitively with AcCoA, and equilibrium measurements reveal AcCoA or CoA binding is not stimulated in the presence of H3 substrate. Additionally, the Rtt109-Vps75 complex binds H3 substrates in the absence AcCoA. Pre-steady-state kinetic analysis suggests the chemical attack of substrate lysine on the bound AcCoA is the rate-limiting step of catalysis, while the pH profile of k(cat) reveals a critical ionization with a pK(a) of 8.5 that must be unprotonated for catalysis. Amino acid substitution at D287 and D288 did not substantially change the shape of the k(cat)-pH profile, suggesting these conserved residues do not function as base catalysts for histone acetylation. However, the D288N mutant revealed a dramatic 1000-fold decrease in k(cat)/K(m) for AcCoA, consistent with a role in AcCoA binding. Together, these data support a sequential mechanism in which AcCoA and H3 bind to the Rtt109-Vps75 complex without obligate order, followed by the direct attack of the unprotonated epsilon-amino group on AcCoA, transferring the acetyl group to H3 lysine residues.
Further results on fault-tolerant distributed classification using error-correcting codes (2004)

In this paper, we consider the distributed classification problem in wireless sensor networks. The DCFECC-SD approach employing the binary code matrix has recently been proposed to cope with the errors caused by both sensor faults and the effect of fading channels. The DCFECC-SD approach extends the DCFECC approach by using soft decision decoding to combat channel fading. However, the performance of the system employing the binary code matrix could be degraded if the distance between different hypotheses can not be kept large. This situation could happen when the number of sensor is small or the number of hypotheses is large. In this paper, we design the DCFECC-SD approach employing the D-ary code matrix, where D>2. Simulation results show that the performance of the DCFECC-SD approach employing the D-ary code matrix is better than that of the DCFECC-SD approach employing the binary code matrix. Performance evaluation of DCFECC-SD using different number of bits of local decision information is also provided when the total channel energy output from each sensor node is fixed.
Expansion Tube Operation with Thin Secondary Diaphragm (2006)

DOI: 10.2514/1.23846 An experimental study of expansion tube operation was conducted by highlighting the interference due to the secondary diaphragm, which separates the shock and acceleration tubes, upon the shock wave transition past the separation. The in-tube processes were diagnosed by framing shadowgraphs and on-wall pressure measurements. Among commercially available diaphragm materials examined, only when using the thinnest Mylar diaphragm (3 � m in thickness), was the shock wave transition not accompanied by serious flow disturbance due to shock wave reflection or to pressure loss through the cloud of ruptured diaphragm fragments. Although cellophane diaphragm was more brittle and suitable for fragmentation, it had the mass penalty caused by its smaller tensile stress and commercial availability, thereby resulting in much larger disturbances.
Preparation of moth-eye structures on curved surfaces by nanoimprinting using anodic porous alumina molds (2022)

Abstract Al substrates with smooth curved surfaces were fabricated by peeling off Al foil sputtered on the surface of concaved substrates. Anodic porous alumina with tapered pores on the curved surface was obtained by repeated anodization and etching of the obtained Al substrate. The moth-eye structure was formed on the curved surface by nanoimprinting using the anodic porous alumina as a mold. From the reflectance measurement, it was shown that the reflection of the incident light was suppressed on the curved surface where the moth-eye structure was formed. This process can be used to fabricate moth-eye structures on the surface of substrates of various shapes by changing the substrate used for sputtering and is expected to expand the range of applications for moth-eye structures.
Démographie, climat et alimentation mondiale (2020)

L'humanité trouvera-t-elle de quoi nourrir 9 milliards d'hommes en 2050, dans un contexte climatique probablement plus difficile ? L'inquiétude n'est pas nouvelle, mais la croissance démographique s'est emballée dans la seconde moitié du XXe siècle, et la crainte d'une crise alimentaire mondiale est réapparue. Certes, les progrès des technologies agricoles ont permis, au plan global, de maintenir le niveau nutritionnel moyen pendant les années de la "Révolution verte", mais la situation restait loin d'être satisfaisante, puisque environ 850 millions de personnes étaient sousalimentées au début du XXIe siècle. Or de nouvelles inquiétudes se font jour : les surfaces cultivables ne sont plus guère extensibles, la productivité des sols atteint des niveaux qui risquent de les endommager de façon irréversible, les prix de l'énergie et des intrants indispensables à l'agriculture moderne sont à la hausse... Et les perspectives de changements climatiques ne sont pas rassurantes. De nouveaux progrès technologiques permettront-ils de dépasser, une fois encore, les contraintes naturelles et démographiques ? Cet ouvrage rappelle d'abord ces contraintes démographiques, climatiques et environnementales qui pèseront sur la disponibilité de ressources à l'horizon 2050, et traite ensuite des facteurs d'évolution de la demande alimentaire, des moyens techniques et économiques d'y faire face, et enfin des conditions d'un équilibre possible. Une synthèse est proposée en début de volume. Des recommandations y sont faites, destinées aux pouvoirs publics français pour les éclairer sur leur politique nationale et internationale, mais aussi à la société civile, qui est concernée car les problèmes ne sont pas seulement scientifiques ou technologiques : ils mettent aussi en jeu les comportements individuels des producteurs et des consommateurs. Trois domaines où il faut agir sans tarder sont mis en valeur : la nutrition et les habitudes alimentaires, puis la démographie, et enfin l'économie mondiale et le commerce international. Les recommandations portent ensuite sur la production agricole et les questions d'environnement, puis sur la prévention, l'anticipation et la gestion des situations de crise, hélas quasi inévitables.
Slump, austerity and resistance (2012)

The Great Recession of 2008-9 represents a profound rupture in the neoliberal era, signalling the exhaustion of the accumulation regime that had emerged almost thirty years earlier. Rather than an ordinary recession, a short-lived downturn in the business cycle, it constituted a systemic crisis, a major contraction whose effects will be with us for many years to come. Among those effects are the extraordinary cuts to social programmes, and the resultant impoverishment, announced as part of the Age of Austerity inaugurated by all major states. But another effect, and for socialists ultimately the crucial one, is a new wave of mass working-class insurgency. Since the onset of the Great Recession, factory occupations, general strikes and street-based uprisings have burst forth from Greece to Guadeloupe and beyond. Whether this insurgent wave will be adequate to the task of overturning the ruling-class agenda is far from clear. What is clear is that the age of austerity has raised the bar for movements of resistance, obliging them to undertake much more militant and decisive oppositional practices or risk major defeats.

Illuminating the context of these class struggles is a strategic necessity for any meaningful Left politics. To that end, this article explores the economic dynamics of the Great Recession, the bailout, and the abnormal ‘recovery’ that followed. It argues that while the recapitalization of banks did stop the financial collapse, monetary policy (‘quantitative easing’) can no more generate sustained growth today than it has in Japan over the past 15 years. As a result, we can expect a prolonged period of austerity, of food crises in the Global South, and of attacks on public services and working classes – all of which raise key political challenges for the Left.
Managing déjà vu: Collection building for the identification of nonidentical duplicate documents (2006)

Abstract As online document collections continue to expand, both on the Web and in proprietary environments, the need for duplicate detection becomes more critical. Few users wish to retrieve search results consisting of sets of duplicate documents, whether identical duplicates or close variants. The goal of this work is to facilitate (a) investigations into the phenomenon of near duplicates and (b) algorithmic approaches to minimizing its deleterious effect on search results. Harnessing the expertise of both client‐users and professional searchers, we establish principled methods to generate a test collection for identifying and handling nonidentical duplicate documents. We subsequently examine a flexible method of characterizing and comparing documents to permit the identification of near duplicates. This method has produced promising results following an extensive evaluation using a production‐based test collection created by domain experts.
Moving table magnetic particle imaging: a stepwise approach preserving high spatio-temporal resolution (2018)

Magnetic particle imaging (MPI) is a highly sensitive imaging method that enables the visualization of magnetic tracer materials with a temporal resolution of more than 46 volumes per second. In MPI, the size of the field of view (FoV) scales with the strengths of the applied magnetic fields. In clinical applications, those strengths are limited by peripheral nerve stimulation, specific absorption rates, and the requirement to acquire images of high spatial resolution. Therefore, the size of the FoV is usually a few cubic centimeters. To bypass this limitation, additional focus fields and/or external object movements can be applied. The latter approach is investigated. An object is moved through the scanner bore one step at a time, whereas the MPI scanner continuously acquires data from its static FoV. Using a 3-D phantom and dynamic 3-D <i>in vivo</i> data, it is shown that the data from such a moving table experiment can be jointly reconstructed after reordering the data with respect to the stepwise object shifts and heart beat phases.
A novel high-throughput on-wafer electromechanical sensitivity characterization system for piezoresistive cantilevers (2012)

In this work we present the development of a new set-up that allows on-wafer sensitivity characterization of piezoresistive cantilevers. In this way we reduce considerably the testing time compared to the techniques available up to date but at the same time we maintain a high measurement precision. Moreover it can be easily used for characterization of broad types of batch fabricated micro- and nanoelectromechanical systems (MEMS and NEMS). Together with the sensitivity measurement we present also the methods to test the cantilever spring constant and the electrical noise. Using these techniques we measured the performance of multiple piezoresistive cantilevers in two wafers and from these values we extracted important fabrication materials parameters such as Young modulus, Hooge and piezoresistive factors.
A fully automatic 2D ultrasound probe calibration method using a simple phantom (2011)

Probe calibration should be performed for free-hand tracking and ultrasound (US) fusion with a position sensor-attached US probe in US guided interventions. Difficulties in locating the probe imaging plane and adjusting the alignment of the probe with the calibration phantom call for more complicated and precise phantoms. However, the manufacture of such phantoms is time-consuming and expensive. Furthermore, the segmentation of the phantom features in US images cannot be reliably automated, which requires manual intervention. This paper presents a fully automatic 2D probe calibration method using a rather simple phantom. By detecting and analyzing the temporal signal arising from the ultrasound artifacts when sweeping the 2D probe over the phantom, the imaging plane of the probe and the image features can be reliably identified. Then the features are fed to a nonlinear optimizer to estimate the calibration parameters. The whole procedure including the setup can be done within 2 minutes with the fiducial registration error (FRE) of 0.16 mm. A US-guided biopsy experiment has also been conducted which shows the target registration error (TRE) of less than 1 mm.
Significance of the first transcribed nucleoside of capped RNA for ligand-induced folding of the cap-binding complex (2005)

Many proteins, including those that bind RNA, change conformation upon binding a ligand, a phenomenon known as induced fit. CBP20, the small subunit of the nuclear cap-binding complex (CBC), recognizes specifically the 5' cap of eukaryotic mRNA and snRNA. The N- and C-terminal regions of the CBP20 subunit of the human nuclear cap-binding complex only acquire a proper fold in complex with capped RNA. The cap is composed of 7-methylguanosine linked by a 5'-to-5' triphosphate bridge to the first transcribed nucleoside of the RNA. The significance of the latter for the capped RNA-CBC association and local folding of CBC has been characterized by emission spectroscopy. Fluorescence titration of CBC has been performed for three selected, mono- and dinucleotide mRNA 5' cap analogues. The measured values of the equilibrium association constant and the corresponding Gibbs free energy depend on the type of the first transcribed nucleoside (purine or pyrimidine), and decrease ∼10-fold in the case of a mononucleotide analogue, 7-methylguanosine triphosphate. However, the total quenching of the intrinsic protein fluorescence is similar for each analogue. Changes of the solvent-accessible CBC hydrophobic surface of CBC on binding of the structurally different cap analogues have been followed using bis-ANS fluorescent probe.
Stroke participants' perceptions of robotic and electrical stimulation therapy: a new approach (2010)

This article demonstrates the value in assessing user perceptions of a rehabilitation system via a simple question set. While the results of this study have implications for a wider audience, our recommendations are for a qualitative study to develop a generic evaluation tool which could be used across the growing number of devices to provide feedback to enhance future development of any new technology for rehabilitation.
A Multiwalled‐Carbon‐Nanotube‐Based Biosensor for Monitoring Microcystin‐LR in Sources of Drinking Water Supplies (2013)

Abstract A multiwalled carbon nanotube (MWCNT)‐based electrochemical biosensor is developed for monitoring microcystin‐LR (MC‐LR), a toxic cyanobacterial toxin, in sources of drinking water supplies. The biosensor electrodes are fabricated using vertically well‐aligned, dense, millimeter‐long MWCNT arrays with a narrow size distribution, grown on patterned Si substrates by water‐assisted chemical vapor deposition. High temperature thermal treatment (2500 °C) in an Ar atmosphere is used to enhance the crystallinity of the pristine materials, followed by electrochemical functionalization in alkaline solution to produce oxygen‐containing functional groups on the MWCNT surface, thus providing the anchoring sites for linking molecules that allow the immobilization of MC‐LR onto the MWCNT array electrodes. Addition of the monoclonal antibodies specific to MC‐LR in the incubation solutions offers the required sensor specificity for toxin detection. The performance of the MWCNT array biosensor is evaluated using micro‐Raman spectroscopy, including polarized Raman measurements, X‐ray photoelectron spectroscopy, cyclic voltammetry, optical microscopy, and Faradaic electrochemical impedance spectroscopy. A linear dependence of the electron‐transfer resistance on the MC‐LR concentration is observed in the range of 0.05 to 20 μg L −1 , which enables cyanotoxin monitoring well below the World Health Organization (WHO) provisional concentration limit of 1 μg L −1 for MC‐LR in drinking water.
Vitamin E Supplements and Risk of Prostate Cancer in U.S. Men (2005)

No AccessJournal of UrologyUrological Survey: Urological Oncology: Prostate Cancer1 Jan 2005Vitamin E Supplements and Risk of Prostate Cancer in U.S. Men Patrick C. WalshM.D. Patrick C. WalshPatrick C. Walsh More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(05)60779-3AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "Vitamin E Supplements and Risk of Prostate Cancer in U.S. Men." The Journal of Urology, 173(1), pp. 87–88 © 2005 by American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 173Issue 1January 2005Page: 87-88 Advertisement Copyright & Permissions© 2005 by American Urological Association, Inc.MetricsAuthor Information Patrick C. Walsh More articles by this author Expand All Advertisement PDF DownloadLoading ...