gebhart/patrepeval huggingface dataset:
Diversity of cells and signals in the cardiovascular system (2023)

This white paper is the outcome of the seventh UC Davis Cardiovascular Research Symposium on Systems Approach to Understanding Cardiovascular Disease and Arrhythmia. This biannual meeting aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2022 Symposium was 'Cell Diversity in the Cardiovascular System, cell-autonomous and cell-cell signalling'. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies, and challenges in examining cell and signal diversity, co-ordination and interrelationships involved in cardiovascular function. This paper originates from the topics of formal presentations and informal discussions from the Symposium, which aimed to develop a holistic view of how the multiple cell types in the cardiovascular system integrate to influence cardiovascular function, disease progression and therapeutic strategies. The first section describes the major cell types (e.g. cardiomyocytes, vascular smooth muscle and endothelial cells, fibroblasts, neurons, immune cells, etc.) and the signals involved in cardiovascular function. The second section emphasizes the complexity at the subcellular, cellular and system levels in the context of cardiovascular development, ageing and disease. Finally, the third section surveys the technological innovations that allow the interrogation of this diversity and advancing our understanding of the integrated cardiovascular function and dysfunction.
Inhibition of Akt survival pathway by a small-molecule inhibitor in human glioblastoma (2006)

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) and Akt are important regulators of the phosphatidylinositol 3-kinase (PI3K) pathway and thus are important to the regulation of a wide spectrum of tumor-related biological processes. Akt regulates several critical cellular functions, including cell cycle progression; cell migration, invasion, and survival; and angiogenesis. Decreased expression of PTEN and overexpression of the Akt proto-oncogene, which is located downstream of PI3K, have been shown in a variety of cancers, including glioblastoma. Novel small-molecule inhibitors of receptors and signaling pathways, including inhibitors of the PI3K pathway, have shown antitumor activity, but inhibitors of Akt have not been examined. In this study, we tested our hypothesis that the pharmacologic inhibition of Akt has an antiproliferative effect on gliomas. We showed that two newly developed Akt inhibitors, KP-372-1 and KP-372-2 (herein called KP-1 and KP-2), effectively inhibited the PI3K/Akt signaling cascade. KP-1 and KP-2 blocked both the basal and epidermal growth factor-induced phosphorylation of Akt Ser473 at 125 and 250 nmol/L, which, in turn, reduced the activation of intracellular downstream targets of Akt, including GSK-3beta and p70s6k. Furthermore, the treatment of U87 and U251 glioma cells with 125 to 250 nmol/L KP-1 and KP2 for 48 hours inhibited cell growth by approximately 50%. This decrease in cell growth stemmed from the induction of apoptosis. Collectively, these results provide a strong rationale for the pharmacologic targeting of Akt for the treatment of gliomas.
Neutron scattering observations on the magnetic phases of rare-earth ternary superconductors (1979)

A number of ternary compounds become superconducting even though they contain a chemically ordered sublattice of magnetic rare-earth ions. Studies of the physical properties of these materials have revealed anomalies below Tc which have been attributed to magnetic ordering transitions. Using neutron spectrometers at the Brookhaven National Laboratory, a group of us has demonstrated that simple magnetic structures with long-range order do occur, and we have solved some of the magnetic structures of these superconductors. Specifically, we have found that in DyMo6S8 and TbMo6S8 an antiferromagnetic structure coexists with superconductivity. In two other compounds, ErRh4B4 and HoMo6S8 we have found that the development of ferromagnetism is responsible for the quenching of superconductivity. A study of the critical magnetic neutron scattering near the superconducting → ferromagnetic transitions shows the presence of fluctuations into a state with an oscillatory magnetization of wave length λ=100 Å.
A Collaborative Approach Using Neural Networks for BLE-RSS Lateration-Based Indoor Positioning (2022)

In daily life, mobile and wearable devices with high computing power, together with anchors deployed in indoor environments, form a common solution for the increasing demands for indoor location-based services. Within the technologies and methods currently in use for indoor localization, the approaches that rely on Bluetooth Low Energy (BLE) anchors, Received Signal Strength (RSS), and lateration are among the most popular, mainly because of their cheap and easy deployment and accessible infrastructure by a variety of devices. Nevertheless, such BLE- and RSS-based indoor positioning systems are prone to inaccuracies, mostly due to signal fluctuations, poor quantity of anchors deployed in the environment, and/or inappropriate anchor distributions, as well as mobile device hardware variability. In this paper, we address these issues by using a collaborative indoor positioning approach, which exploits neighboring devices as additional anchors in an extended positioning network. The collaborating devices' information (i.e., estimated positions and BLE-RSS) is processed using a multilayer perceptron (MLP) neural network by taking into account the device specificity in order to estimate the relative distances. After this, the lateration is applied to collaboratively estimate the device position. Finally, the stand-alone and collaborative position estimates are combined, providing the final position estimate for each device. The experimental results demonstrate that the proposed collaborative approach outperforms the stand-alone lateration method in terms of positioning accuracy.
The interaction of subjective experience and attitudes towards specific antipsychotic-related adverse effects in schizophrenia patients (2012)

Negative attitude towards most adverse drug effects did not correlate with personal experience. Drug-related affective flattening should be evaluated routinely, since experiencing it may predict negative attitude towards drugs, potentially leading to poor compliance and relapse.
Supplementary Figure 1 from Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype (2023)

Supplementary Figure 1 from Epithelial-Mesenchymal Transition in Breast Cancer Relates to the Basal-like Phenotype
Synthesis and crystal structure determination of model compounds for the dibenzodioxocine structure occurring in wood lignins (1996)

Model compounds for the dibenzodioxocine structure, a new structural unit recently discovered in wood lignins, have been synthesised by two different methods. In one route, the 8-membered ring is formed by ring closure of an arylglycerol β-aryl ether with a 5,5′-biphenyl structure in the aryl ether moiety. The other, which gave better yields, involves a biomimetic oxidative phenol coupling. Crystal structures have been obtained for one β-aryl ether and of two dibenzodioxocine isomers, as well as of a product of acid hydrolysis containing a 7-membered ring structure.
Increasing the composition range of a novel τ11-Al4Fe1.7Si alloy with additions of Mn (2022)

Automotive applications need low-cost, lightweight, high-temperature alloys to increase vehicle efficiency. The Al–Fe–Si system provides an opportunity to develop such a material, as it consists of three low-cost elements that are all abundant in nature. Specifically, the τ11-Al4Fe1.7Si ternary intermetallic phase is a high-temperature, lightweight phase with high strength and good corrosion resistance. However, this phase exhibits a narrow compositional range of stability, resulting in undesirable microstructures forming during solidification and processing, limiting its use in potential applications. Density functional theory (DFT) calculations and a thermodynamically-driven experimental approach utilizing diffusion couples were employed to study the effect of Mn on the stability and composition range of τ11-Al4Fe1.7Si. The DFT calculations showed a decrease in the energy of the structure when alloying with Mn. Experimental results confirmed the predictions from the DFT calculations, indicating that alloying with Mn increases the compositional range, and thus the processability of this phase. New phase diagrams and equilibria are proposed by exploring and determining phase boundaries for the τ11-Al4Fe1.7Si phase with Mn.
Low-noise, high-energy, single-mode, femtosecond fiber laser system (2005)

Truly single-mode amplification of femtosecond pulses from a fiber oscillator to /spl sim/100 nJ is demonstrated. Amplitude and phase noise characterization of the source and its robustness demonstrates its potential for many applications.
On the integral equation of the vector Preisach hysteresis model (1987)

The isotropic vector Preisach model of hysteresis is briefly described and the problem of fitting experimental data by this model is posed in terms of a specific integral equation. A closed form solution to this integral equation is found. The analytical theory is illustrated by a numerical example.
Rapid monocyte infiltration following retinal detachment is dependent on non-canonical IL6 signaling through gp130 (2017)

Together, our results demonstrate that monocytes are the primary immune cell mediating the cytokine storm following RD, and that any resulting retinal damage is unlikely to be a direct result of retinal IL6 signaling, but rather gp130-mediated signaling in the monocytes themselves. These results suggest that RD should be treated immediately, and that gp130-directed therapies may prevent PVR and promote retinal healing.
MINER - a mobile imager of neutrons for emergency responders (2014)

Our research group has been developing a fast neutron imaging platform to enhance the capabilities of emergency responders in the localization and characterization of special nuclear material. This mobile imager of neutrons for emergency responders (MINER) is a compact neutron scatter camera optimized to provide omni-directional (4-Pi) imaging with only a ~twofold decrease in sensitivity compared to our much larger neutron scatter cameras. The system performance is tuned for fission energy neutron imaging and spectroscopy, and it also can function as a Compton camera for gamma imaging. Results will be presented relating to detector response as well as several measurement campaigns at external facilities.
Mechanical measurements on lithium phosphorous oxynitride coated silicon thin film electrodes for lithium-ion batteries during lithiation and delithiation (2016)

The development of large stresses during lithiation and delithiation drives mechanical and chemical degradation processes (cracking and electrolyte decomposition) in thin film silicon anodes that complicate the study of normal electrochemical and mechanical processes. To reduce these effects, lithium phosphorous oxynitride (LiPON) coatings were applied to silicon thin film electrodes. Applying a LiPON coating has two purposes. First, the coating acts as a stable artificial solid electrolyte interphase. Second, it limits mechanical degradation by retaining the electrode's planar morphology during cycling. The development of stress in LiPON-coated electrodes was monitored using substrate curvature measurements. LiPON-coated electrodes displayed highly reproducible cycle-to-cycle behavior, unlike uncoated electrodes which had poorer coulombic efficiency and exhibited a continual loss in stress magnitude with continued cycling due to film fracture. The improved mechanical stability of the coated silicon electrodes allowed for a better investigation of rate effects and variations of mechanical properties during electrochemical cycling.
Inflammation and lymphocyte infiltration are associated with shorter survival in patients with high-grade glioma (2020)

Glioma represents a serious health burden in terms of morbidity and mortality. The prognostic significance of the lymphoid and myeloid infiltrates in glioma is not clearly determined. Moreover, the characterization of different leukocyte subsets in the tumor microenvironment relies mainly on immunohistochemistry observations, and data about their association with prognosis are contradictory. Here, we performed acomprehensive study of both the tumor-infiltrating and circulating immune compartments of patients with high-grade glioma. Nineteen tumor biopsies and 30 PBMC samples were analyzed by RNA sequencing. Validation was performed on The Cancer Genome Atlas (TCGA) RNA sequencing data from glioma and on additional 39 tumor biopsies analyzed by flow cytometry. We identified prognostic tumor and peripheral immune signatures, which associate increased inflammation, immune infiltration and activation with shorter overall survival in high-grade glioma patients. Importantly, we confirmed our observations by flow cytometry analysis and validated the tumor-signature using the TCGA dataset. In addition, both tumor genotype and grade associated with the degree of glioma immune infiltration. Unlike in the majority of cancers, lymphocyte infiltration at the tumor site is anegative prognostic factor in glioma, suggesting the ambivalent pro-tumorigenic role of immune responses in glioma.
Comparative genomics of the dairy isolate Streptococcus macedonicus ACA-DC 198 against related members of the Streptococcus bovis/Streptococcus equinus complex (2014)

Our whole genome analyses suggest traits of adaptation of S. macedonicus to the nutrient-rich dairy environment. During this process the bacterium gained genes presumably important for this new ecological niche. Finally, S. macedonicus carries a reduced number of putative SBSEC virulence factors, which suggests a diminished pathogenic potential.
Analysis of twist level and take-up speed impact on the tensile properties of PVA/PA6 hybrid nanofiber yarns (2016)

Abstract In this work, polyvinyl alcohol/nylon6 hybrid nanofiber yarns were produced to achieve good properties of each component. The influence of the twist level in the range of 3000–14,666 tpm and take-up speed in the range of 2.5–8.5 cm/min of yarns on the tensile properties was investigated. The highest strength and elongation at break of yarns were achieved in twist level and take-up speed of about 11,000 tpm (8.13±0.72 cN/tex and 72.44±7.64%) and 6.5 cm/min (6.20±0.57 cN/tex and 70.23±7.95%), respectively. Excessive values over these amounts caused a drastic decrement in tensile properties. This could be due to the loss nanofiber arrangement in the yarn structure that was confirmed by the study of orientation of the nanofibers in the yarns by the SEM images. These yarns have the potential to be used in medical applications such as a non-absorbable suture due to the drug loading ability and bio-compatibility properties of PVA nanofibers.
Concept design of a multi-band shared aperture reflectarray/reflector antenna (2016)

A scalable dual-band (Ka/W) shared-aperture antenna system design has been developed as a proposed solution to meet the needs of the planned NASA Earth Science Aerosol, Clouds, and Ecosystem (ACE) mission. The design is comprised of a compact Cassegrain reflector/reflectarray with a fixed pointing W-band feed and a cross track scanned Ka-band Active Electronically Scanned Array (AESA). Critical Sub-scale prototype testing and flight tests have validated some of the key aspects of this innovative antenna design, including the low loss reflector/reflectarray surface. More recently the science community has expressed interest in a mission that offers the ability to measure precipitation in addition to clouds and aerosols. In this paper we present summaries of multiple designs that explore options for realizing a tri-frequency (Ku/Ka/W), shared-aperture antenna system to meet these science objectives. Design considerations include meeting performance requirements while emphasizing payload size, weight, prime power, and cost. The extensive trades and lessons learned from our previous dual-band ACE system development were utilized as the foundation for this work.
Dynamics of two-dimensional soap froths (1987)

We have studied experimentally the dynamics of soap froths in two dimensions. We observe two temporal regimes: a transient in which the average bubble area increases in time faster than a power law, and long-term behavior in which the average bubble area increases (over the decade observed) as a power law with exponent \ensuremath{\alpha}${=0.59}_{\mathrm{\ensuremath{-}}0.09}^{+0.11}$. The crossover between these two regimes depends on the initial preparation. In initially disordered systems the rate of area growth increases smoothly and monotonically, whereas in initially ordered systems the rate first overshoots its long-term value and then decreases. The system does not, however, equilibrate during the lifetime of the bubble lattice. We have also verified that Von Neumann's law for the growth rates of bubbles holds statistically. Lewis's hypothesis of a linear relation between a bubble's number of sides and its area fails for few-sided bubbles. Finally we present a simple phenomenological model for the growth of the average area. This model allows us to define a parameter ?(t) quantifying the disorder as a function of time.
Supplementary Figure S5 from Phase I Study of SYNB1891, an Engineered &lt;i&gt;E. coli&lt;/i&gt; Nissle Strain Expressing STING Agonist, with and without Atezolizumab in Advanced Malignancies (2023)

&lt;p&gt;Supplemental Figure 5. Tumor biopsy gene expression changes in chemokine, cytokine and TLR related signaling pathways after SYNB1891 treatment.&lt;/p&gt;
Advanced high-Q resonators for next-generation frequency microcombs (2023)

High-Q optical resonators offer access to nonlinear physics at low pumping powers attainable using non-amplified semiconductor lasers. Recent resonator advances offer Q factors over 200 million in platforms that are fully CMOS compatible. I will review these new systems and how they are making possible a new generation of frequency microcombs.
Novel Nanoporous Coordination Polymer Sustained by Self-Assembly of T-Shaped Moieties (1999)

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTNovel Nanoporous Coordination Polymer Sustained by Self-Assembly of T-Shaped MoietiesHolly Gudbjartson, Kumar Biradha, Karen M. Poirier, and Michael J. ZaworotkoView Author Information Department of Chemistry, The University of Winnipeg Winnipeg, Manitoba, R3B 2E9, Canada Cite this: J. Am. Chem. Soc. 1999, 121, 11, 2599–2600Publication Date (Web):March 6, 1999Publication History Received20 July 1998Published online6 March 1999Published inissue 1 March 1999https://pubs.acs.org/doi/10.1021/ja982577ahttps://doi.org/10.1021/ja982577arapid-communicationACS PublicationsCopyright © 1999 American Chemical SocietyRequest reuse permissionsArticle Views816Altmetric-Citations257LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Aromatic compounds,Crystal structure,Hydrocarbons,Molecular structure,Supramolecular chemistry Get e-Alerts
Quantitative Study of the Effect of Non-Uniform Irradiance on Module Performance Combining EL and DLIT Imaging with Circuit Modeling (2018)

This paper presents a quantitative study of how the non-uniform irradiance from solar simulators and the often overlooked non-uniformities in modules (e.g. mismatched cell performance in a module, connection of cell strings, bypass diodes) affect the measurement accuracy in Si module power calibrations. By implementing spatial non-uniformity maps of solar simulators and experimental diode parameters of individual cells in a module to our circuit model, it enables a better understanding of the interaction of simulator irradiance non-uniformity with module imperfections in module power measurements. The comparison between simulation and experiment shows that with a nonuniform irradiance of 3%, the P <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">MAX</sub> deviations could be as low as ~0.5 % for good-quality Si modules, and ~2% for poor-quality Si modules, confirming the sensitivity of module power calibrations to module properties.
Downregulation of Cytokines and Chemokines by GB Virus C After Transmission Via Blood Transfusion in HIV-Positive Blood Recipients (2014)

GBV-C has a protective effect, in part through a competition mechanism leading to decreased inflammation and improved HIV disease outcome in cases. Further studies are necessary to establish whether GBV-C may have deleterious effects on the host at the cellular level, including depleting the cells that are the targets of HIV.
Compact Dual-Band Dual-Polarized Base-Station Antenna Array With a Small Frequency Ratio Using Filtering Elements (2019)

This paper presents a compact dual-band ±45° dual-polarized base-station array based on embedded filtering elements. The proposed antenna array consists of 9 dual-band antenna units, which operate at the lower band (LB) of 790-862 MHz and the higher band (HB) of 880-960 MHz with a small frequency spacing. In each unit, one antenna element is embedded into the other one, featuring a very compact size. To alleviate the serious cross-band mutual coupling between the two elements, the LB patch antenna generates a boresight radiation null at its higher band edge, and the HB element is designed with a band-stop response at its lower band edge. In this way, high cross-band isolation between the two embedded elements can be obtained. For demonstration, a compact dual-band ±45° dual-polarized filtering antenna array with 9 units is designed and fabricated to fit the specification of LB and HB bands (|S <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">11</sub> | <;-15 dB). The overall width of the array is only 280 mm, which is much narrower than that of typical industrial products using two side-by-side sub-arrays (~576 mm). The measured performance of the antenna array can meet the requirement of base stations.
Passing of gallstones via the urethra: a complication of laparoscopic cholecystectomy. (1997)

Laparoscopic cholecystectomy (LC) is the treatment of choice for uncomplicated gallstone (GS) disease. We present a rare complication in a patient with a persistent urachus who, 9 months after LC with intraperitoneal spillage, started to pass GS when urinating.