gebhart/patrepeval huggingface dataset:
Innovative Heavy Landing System for Ultradeep Offshore: Extended Slip Crush Resistant Tube, Enhanced Slip Design and Heavy Weight Carrier (2014)

Abstract The offshore industry's current trend is driving towards ultra deepwater wells, combined with deeper total depths. In order to be able to set and run larger and heavier casing strings with hook loads approaching or exceeding 2.5 million lbs, an innovative heavy duty landing system has been developed and put on the market. Such systems must be capable of landing heavy loads while ensuring slip crush resistance. It includes an extended slip with enhanced design (coupled with a new greasing system), a 2.5 million lbs landing carrier and a pipe with a thick walled high strength material section, a light weight tube, and a rotary shouldered connection. One of the current operational challenges with existing heavy duty landing strings is linked to the positioning of the slips, in particular when using extended slip designs. The limited length of the slips area requires additional time for proper positioning and set up. To address these issues, a new slip proof section design has been developed: the combination of an extended crush proof section and the absence of a heat affected zone in that particular area decreases running time while completely eliminating the risk of setting the slips on a weak point. The "Spiri-Reinhold pipe crushing" formula has been used to design this system. However, considering the approximation of this model's results, crushing performance has been assessed using the Finite Element Analysis, as well as physical tests performed with a specifically designed pulling unit. These full scale test results have been compared to the ones obtained with both the Finite Element Analysis and the standard "Spiri-Reinhold pipe crushing" formula.
Isolation of highly purified mouse CD4+CD25+FoxP3+ T regulatory cells in less than 45 minutes (IRC4P.476) (2014)

Abstract Regulatory T cells (Tregs), a subset of lymphocytes, play a key role in maintaining peripheral tolerance, preventing autoimmune diseases and limiting chronic inflammatory diseases. They can be broadly classified into natural or adaptive (induced) Tregs. Natural Tregs (CD4+CD25+FoxP3+), develop in the thymus and emigrate to the periphery to help maintain immune homeostasis. Adaptive Tregs can be induced from CD25-negative naïve CD4+ T cells in the thymus and acquire CD25 (IL-2R alpha) and FoxP3 expression in the periphery after adequate antigenic stimulation. They are typically induced by chronic allergic inflammation and disease processes, such as autoimmunity. The isolation of highly purified Tregs is essential for advancing research in this field. To date this has been achieved by lengthy protocols or flow-based cell sorting. We have developed a rapid column-free one-step immunomagnetic cell separation method (EasySep™) to isolate Tregs (natural and induced) from mouse splenocytes in less than 45 minutes. CD25-PE-labelled cells are bound to magnetic particles using antibody complexes and separated using an EasySep™ magnet. The procedure can be automated using RoboSep™. Starting from 2.2±0.4% Tregs, purities of 84±3% (mean±SD, n=20) CD4+CD25+FoxP3+ cells can be achieved. This kit provides a new tool to study the mechanisms by which Tregs exert their influence, which has broad implications for the development of cell-based therapies for autoimmune disease and cancer.
Repression of Platelet-derived Growth Factor A-chain Gene Transcription by an Upstream Silencer Element (1996)

Platelet-derived growth factor A-chain is a potent mitogen expressed in a restricted number of normal and transformed cells. Transient transfection and deletion analysis in BSC-1 (African green monkey, renal epithelial) cells revealed that the -1680 to -1374 region of the A-chain gene repressed homologous and heterologous promoter activities by 60-80%. An S1 nuclease-hypersensitive region (5'SHS) was identified within this region (-1418 to -1388) that exhibited transcriptional silencer activity in BSC-1 and a variety of human tumor cell lines (U87, HepG2, and HeLa). Electrophoretic mobility shift assays conducted with 5'SHS oligodeoxynucleotide probes revealed several binding protein complexes that displayed unique preferences for binding to sense, antisense, and double-stranded forms of the element. Southwestern blot analysis revealed that the antisense strand of 5'SHS binds to nuclear proteins of molecular mass 97, 87, 44, and 17 kDa, whereas the double-stranded form of 5'SHS is recognized by a 70-kDa factor. Mutations within 5'SHS element indicated the necessity of a central 5'-GGGGAGGGGG-3' motif for protein binding and silencer function, while nucleotides flanking both sides of the motif were also critical for repression. These results support a model in which silencer function of 5'SHS is mediated by antisense strand binding proteins, possibly by stabilizing single-stranded DNA conformations required for interaction with enhancer sequences in the proximal promoter region of the A-chain gene.
HTS, Chemical Hybridization, and Drug Design Identify a Chemically Unique Antituberculosis Agent–Coupling Serendipity and Rational Approaches to Drug Discovery (2007)

The high throughput screening of two chemical libraries against Mycobacterium tuberculosis led to the design of hybrid compounds by using nitrile oxide cycloaddition chemistry. One of the hybrids shows an excellent MIC against M. tuberculosis H37Rv. As this molecule shows no CYP3A4 inhibition and a maximum tolerated dose of ≥200 mg kg−1 po in mice, it represents a potential drug candidate for TB therapy. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2452/2007/z700048_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Large multiconfigurational Hartree-Fock calculations on the hyperfine-structure constants of the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow><mml:mi mathvariant="normal">Li</mml:mi></mml:mrow><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>7</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math>2<i>s</i><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow/><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math><i>S</i>and 2<i>p</i><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:mmultiscripts><mml:mrow/><mml:mprescripts/><mml:mrow/><mml:mrow><mml:mn>2</mml:mn></mml:mrow><mml:mrow/><mml:mrow/></mml:mmultiscripts></mml:mrow></mml:math><i>P</i>states (1992)

Accurate hyperfine-structure parameters for the ground and first excited states of lithium are reported. Hyperfine parameters are calculated from multiconfiguration Hartree-Fock (MCHF) wave functions using a recently written hyperfine-structure program, being a part of the MCHF Atomic Structure Package. Convergence of the hyperfine-strucure parameters is studied as the active set of orbitals is increased. The relativistic, finite-nuclear-size, and finite-nuclear-mass-corrected values of the magnetic hyperfine-structure constants of the 2s $^{2}$${\mathit{S}}_{1/2}$ and 2p $^{2}$${\mathit{P}}_{1/2,3/2}$ states of $^{7}\mathrm{Li}$ were determiend to be ${\mathit{A}}_{1/2}$=401.70 MHz and ${\mathit{A}}_{1/2}$=45.94 MHz, ${\mathit{A}}_{3/2}$=3.098 MHz, respectively. The final values are compared with experiments and with the most reliable theoretical values obtained with other methods.
The synthesis of triphenylene-based discotic mesogens New and improved routes (1993)

Abstract The synthesis of discotic liquid crystal materials based on the triphenylene core normally involves the preparation of hexahydroxytriphenylene. This has traditionally been accomplished by a chloranil promoted trimerization of 1,2-dimethoxy-benzene followed by demethylation of the hexamethoxytriphenylene produced. Hexahydroxytriphenylene is subsequently alkylated to give the required derivative. The overall yield of this three step procedure is low and it is difficult to perform on a large scale. It is herein shown that a modified procedure using iron III chloride instead of chloranil yields hexa-alkoxytriphenylenes in a single step. The reaction is high yielding and can be performed on a large scale. This also provides a better route than those currently available for making the unsymmetrically substituted tri-phenylenes required in the synthesis of polymeric discotic liquid crystals. Some related elaborations of the triphenylene nucleus are also discussed.
Dual RNA-seq reveals viral infections in asthmatic children without respiratory illness which are associated with changes in the airway transcriptome (2017)

In our recent article [1], it has come to our attention that the sample labels are not consistent between Table 1, the data labels deposited in the Sequence Read Archive, and Additional file 1: Table S2. We are therefore providing an updated Additional file 1: Table S2 so identical samples now have the same label.
Preface (2004)

ADVERTISEMENT RETURN TO BOOKPREVPrefaceNEXTPrefaceBadal C. SahaBadal C. SahaFermentation Biotechnology Research Unit National Center for Agricultural Utilization Research Agricultural Research Service U.S. Department of Agriculture 1815 North University Street Peoria, IL 61604 (309) 681-6276 (telephone) (309) 681-6427 (fax) [email protected] (email)More by Badal C. Saha and Kiyoshi HayashiKiyoshi HayashiPlanning Section National Food Research Institute 2-1-12, Kannondai Tsukuba, Ibaraki 305-8642 Japan +81-298-38-7991 (telephone) +81-298-38-8005 (fax) [email protected] (email)More by Kiyoshi HayashiDOI: 10.1021/bk-2004-0889.pr001 This publication is free to access through this site. Learn MorePublication Date (Print):July 29, 2004Publication History Published online23 July 2009Published inprint 29 July 2004Request reuse permissions Copyright © 2004 American Chemical Society. This publication is available under these Terms of Use. Lignocellulose Biodegradationpp xi-xiiiACS Symposium SeriesVol. 889ISBN13: 9780841238763eISBN: 9780841220027Chapter Views183Citations-LEARN ABOUT THESE METRICSChapter Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (212 KB) Get e-Alerts
Cyclopentadien-Komplexe als Synthesebausteine: Ring- und regiospezifische nucleophile Addition an Cobaltocenium-Salze - Synthese substituierter Cyclopentadiene und Cyclopentenone (2006)

Das vollständige Manuskript dieser Zuschrift erscheint in: Angew. Chem. Suppl. 1982, 1360. DOI: 10.1002/ange.198213600
Torque ripple reduction of permanent magnet synchronous motors based on predictive sequence control (2017)

To reduce the torque ripples of permanent magnet synchronous motor, this paper proposes a predictive sequence control (PSC) algorithm. Comparing with conventional predictive torque control, PSC takes different switching sequences applied to synthesize voltage vectors into account, and the switching sequence that produces minimum torque ripples will be selected by corresponding predictive algorithm. Therefore, the proposed PSC will achieve excellent torque performance.
A General Design Procedure for Multi-Parallel Modular Grid-Tied Inverters System to Prevent Common and Interactive Instability (2019)

Based on the equivalent circuit model, the interactions of multi-parallel modular grid-tied inverters and their coupling effect with grid impedance are analyzed in this letter. The analysis shows that interactive instability could happen in the inverter system even when identical inverters have been used. However, if the control and circuit parameters are designed systematically, the system can be exempted from both common and interactive instability. The outcome of this research provides a practical general design paradigm for modular grid-tied inverters with inductor-capacitor-inductor (LCL) filters which can be used in the parallel operation with unknown number of modules. Experimental results are provided for verification.
The Relationship Between Obstructive Sleep Apnea and Self-Reported Stroke or Coronary Heart Disease in Overweight and Obese Adults with Type 2 Diabetes Mellitus (2012)

We found suggestive evidence of a greater prevalence of stroke at greater values of the AHI. OSA was not associated with prevalent coronary heart disease in the Sleep AHEAD trial. Future studies should confirm the link between OSA and stroke and examine mechanisms that link OSA to stroke in adults with T2DM.
Trapping of Stable [4<i>n</i>+1] π‐Electron Species from Peripherally Substituted, Conformationally Rigid, Antiaromatic Hexaphyrins (2019)

Peripherally substituted antiaromatic naphthorosarins have been synthesized for the first time. The synthesis was accomplished by acid-catalyzed condensation of naphthobipyrrole building blocks with aromatic aldehydes. The naphthobipyrrole building blocks were synthesized by simple oxidative coupling of the corresponding pyrrole substituted aromatics. Solid-state structural analyses of the synthesized naphthorosarins revealed that the presence of meso-2,6-dichlorophenyl- and 5,6-difluoro-substitution substantially alter the geometry and properties of the naphthorosarins. The substituents affect the redox potentials as well and, in turn, the proton-coupled electron-transfer processes leading to the formation of one- and two-electron reduced forms of the corresponding naphthorosarins. One particular naphthorosarin that bears both peripheral fluorine and meso-2,6-dichlorophenyl substituents forms a stable 25 π-electron species upon treating with TFA that was characterized by single-crystal X-ray diffraction analysis. The current study underscores how structural modifications can be used to fine-tune the electronic features of naphthorosarins, including stabilization of odd electron species.
Identification and Mutational Analysis of Amino Acid Residues Involved in Dipyridamole Interactions with Human and Caenorhabditis elegans Equilibrative Nucleoside Transporters (2005)

The equilibrative nucleoside transporters, hENT1 and CeENT1 from humans and Caenorhabditis elegans, respectively, are inhibited by nanomolar concentrations of dipyridamole and share a common 11-transmembrane helix (TM) topology. Random mutagenesis and screening by functional complementation in yeast for clones with reduced sensitivities to dipyridamole yielded mutations at Ile429 in TM 11 of CeENT1 and Met33 in TM 1 of hENT1. Mutational analysis of the corresponding residues of both proteins suggested important roles for these residues in competitive inhibition of hENT1 and CeENT1 by dipyridamole. To verify the roles of these residues in dipyridamole interactions, hENT2, which naturally exhibits low dipyridamole sensitivity, was mutated to contain side chains favorable for high affinity dipyridamole binding (i.e. a Met at the TM 1 and/or an Ile at the TM 11 positions). The single mutants exhibited increased hENT2 sensitivity to inhibition by dipyridamole, and the double mutant was the most sensitive, with an IC50 value that was only 2% of that of wild type. Functional analysis of the TM 1 and 11 mutants of hENT1 and CeENT1 revealed that Ala and Thr in the TM 1 and 11 positions, respectively, impaired uridine and adenosine transport and that Leu442 of hENT1 was involved in permeant selectivity. Mechanistic and structural models of dipyridamole interactions with the TM 1 and 11 residues are proposed. This study demonstrated that the corresponding residues in TMs 1 and 11 of hENT1, hENT2, and CeENT1 are important for dipyridamole interactions and nucleoside transport.
The Role of Therapeutic Modalities in Surgical and Nonsurgical Management of Orthopaedic Injuries (2017)

Rehabilitation professionals often use therapeutic modalities as a component of the surgical and nonsurgical management of orthopaedic injuries. Myriad therapeutic modalities, including cryotherapy, thermotherapy, ultrasonography, electrical stimulation, iontophoresis, and laser therapy, are available. Knowledge of the scientific basis of each modality and the principles of implementation for specific injuries enables musculoskeletal treatment providers to prescribe these modalities effectively. The selection of specific therapeutic modalities is based on their efficacy during a particular phase of rehabilitation. Therapeutic modalities are an adjunct to standard exercise and manual therapy techniques and should not be used in isolation.
Association of Body Mass Index With Disability in Activities of Daily Living Among Chinese Adults 80 Years of Age or Older (2018)

Higher BMI was associated with a lower risk of disability in ADL among Chinese adults age 80 years or older, which suggests that current recommendations for BMI may need to be revisited. More attention should be paid on underweight, rather than overweight or obesity, for the prevention of disability in ADL after age 80 years.
Response to Comment on “Factors Associated With the Early Outcome in Living Donor Liver Transplantation in Reply to Sonbare” (2018)

Akamatsu, Nobuhisa PhD; Hasegawa, Kiyoshi MD, PhD; Kokudo, Norihiro MD, PhD Author Information
Understanding Color Memory: A Study of Skin Tone Perception in Hue, Intensity, and Chroma (2023)

Perceptually, one of the strongest memory colors is skin tone. Get it wrong and it is hard to miss. Image adjustments are commonly applied for preference-based image enhancement. Because these adjustments are performed across a variety of color spaces, it is important to understand their effects on skin tone appearance. In this article, results of a psychovisual experiment that explores the perception of skin tone under changes in hue, chroma, and intensity are presented. By combining the effects each axis has on the perception of different skin tones, viewer expectations of color appearance can be evaluated. The experimental results convey a low tolerance for changes in hue when altering intensity and chroma and a high tolerance for changes in intensity across all adjustments. When altering intensity, the results present changes in chroma that follow the shape of the ITU-R BT.2124 (ITP) gamut hull. There was some variability between skin tones. This speaks to how individual skin tone classification may be helpful to preserve appearance following adjustment.
Experimental results of 40-kA Nb/sub 3/Al cable-in-conduit conductor for fusion machines (1994)

A 40-kA Nb/sub 3/Al cable-in-conduit conductor has been developed for the toroidal field coils of fusion reactors, because Nb/sub 3/Al has excellent mechanical performance. This conductor consists of 405 copper-stabilized multifilamentary strands inserted into a CuNi circular conduit. The Nb/sub 3/Al strands are fabricated by the Jelly-roll process with a diameter of 1.22 mm. This conductor could be operated up to a current of 46 kA at an external field of 11.2 T. Accordingly, Nb/sub 3/Al promises to soon become a useful superconductor for large-scale high-field applications, such as fusion machines.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Epigenetic Modifier Supplementation Improves Mitochondrial Respiration and Growth Rates and Alters DNA Methylation of Bovine Embryonic Fibroblast Cells Cultured in Divergent Energy Supply (2022)

Epigenetic modifiers (EM; methionine, choline, folate, and vitamin B<sub>12</sub>) are important for early embryonic development due to their roles as methyl donors or cofactors in methylation reactions. Additionally, they are essential for the synthesis of nucleotides, polyamines, redox equivalents, and energy metabolites. Despite their importance, investigation into the supplementation of EM in ruminants has been limited to one or two epigenetic modifiers. Like all biochemical pathways, one-carbon metabolism needs to be stoichiometrically balanced. Thus, we investigated the effects of supplementing four EM encompassing the methionine-folate cycle on bovine embryonic fibroblast growth, mitochondrial function, and DNA methylation. We hypothesized that EM supplemented to embryonic fibroblasts cultured in divergent glucose media would increase mitochondrial respiration and cell growth rate and alter DNA methylation as reflected by changes in the gene expression of enzymes involved in methylation reactions, thereby improving the growth parameters beyond Control treated cells. Bovine embryonic fibroblast cells were cultured in Eagle's minimum essential medium with 1 g/L glucose (Low) or 4.5 g/L glucose (High). The control medium contained no additional OCM, whereas the treated media contained supplemented EM at 2.5, 5, and 10 times (×2.5, ×5, and ×10, respectively) the control media, except for methionine (limited to ×2). Therefore, the experimental design was a 2 (levels of glucose) × 4 (levels of EM) factorial arrangement of treatments. Cells were passaged three times in their respective treatment media before analysis for growth rate, cell proliferation, mitochondrial respiration, transcript abundance of methionine-folate cycle enzymes, and DNA methylation by reduced-representation bisulfite sequencing. Total cell growth was greatest in High ×10 and mitochondrial maximal respiration, and reserve capacity was greatest (<i>p</i> < 0.01) for High ×2.5 and ×10 compared with all other treatments. In Low cells, the total growth rate, mitochondrial maximal respiration, and reserve capacity increased quadratically to 2.5 and ×5 and decreased to control levels at ×10. The biological processes identified due to differential methylation included the positive regulation of GTPase activity, molecular function, protein modification processes, phosphorylation, and metabolic processes. These data are interpreted to imply that EM increased the growth rate and mitochondrial function beyond Control treated cells in both Low and High cells, which may be due to changes in the methylation of genes involved with growth and energy metabolism.
The COR1 Inner Coronagraph for STEREO-SECCHI (2004)

The Solar Terrestrial Relations Observatory (STEREO) is a pair of identical satellites that will orbit the Sun so as to drift ahead of and behind Earth respectively, to give a stereo view of the Sun. STEREO is currently scheduled for launch in November 2005. One of the instrument packages that will be own on each of the STEREO spacecrafts is the Sun Earth Connection Coronal and Heliospheric Investigation (SECCHI), which consists of an extreme ultraviolet imager, two coronagraphs, and two side-viewing heliospheric imagers to observe solar coronal mass ejections all the way from the Sun to Earth. We report here on the inner coronagraph, labeled COR1. COR1 is a classic Lyot internally occulting refractive coronagraph, adapted for the first time to be used in space. The field of view is from 1.3 to 4 solar radii. A linear polarizer is used to suppress scattered light, and to extract the polarized brightness signal from the solar corona. The optical scattering performance of the coronagraph was first modeled using both the ASAP and APART numerical modeling codes, and then tested at the Vacuum Tunnel Facility at the National Center for Atmospheric Research in Boulder, Colorado. In this report, we will focus on the COR1 optical design, the predicted optical performance, and the observed performance in the lab. We will also discuss the mechanical and thermal design, and the cleanliness requirements needed to achieve the optical performance.