gebhart/patrepeval huggingface dataset:
A hybrid Scatter/Transform cloaking model (2015)

A new Scatter/Transform cloak is developed that combines the light bending of refraction characteristic of a Transform cloak with the scatter cancellation characteristic of a Scatter cloak. The hybrid cloak incorporates both Transform’s variable index of refraction with modified linear intrusions to maximize the Scatter cloak effect. Scatter/Transform improved the scattering cross-section of cloaking in a 2-dimensional space to 51.7% compared to only 39.6% or 45.1% respectively with either Scatter or Transform alone. Metamaterials developed with characteristics based on the new ST hybrid cloak will exhibit superior cloaking capabilities.
Transcriptome and Proteome Profiling of Neural Induced Pluripotent Stem Cells from Individuals with Down Syndrome Disclose Dynamic Dysregulations of Key Pathways and Cellular Functions (2019)

Down syndrome (DS) or trisomy 21 (T21) is a leading genetic cause of intellectual disability. To gain insights into dynamics of molecular perturbations during neurogenesis in DS, we established a model using induced pluripotent stem cells (iPSC) with transcriptome profiles comparable to that of normal fetal brain development. When applied on iPSCs with T21, transcriptome and proteome signatures at two stages of differentiation revealed strong temporal dynamics of dysregulated genes, proteins and pathways belonging to 11 major functional clusters. DNA replication, synaptic maturation and neuroactive clusters were disturbed at the early differentiation time point accompanied by a skewed transition from the neural progenitor cell stage and reduced cellular growth. With differentiation, growth factor and extracellular matrix, oxidative phosphorylation and glycolysis emerged as major perturbed clusters. Furthermore, we identified a marked dysregulation of a set of genes encoded by chromosome 21 including an early upregulation of the hub gene APP, supporting its role for disturbed neurogenesis, and the transcription factors OLIG1, OLIG2 and RUNX1, consistent with deficient myelination and neuronal differentiation. Taken together, our findings highlight novel sequential and differentiation-dependent dynamics of disturbed functions, pathways and elements in T21 neurogenesis, providing further insights into developmental abnormalities of the DS brain.
Aspects of MIMO Channel Estimation for LTE Uplink (2011)

The use of MIMO (Multiple Input Multiple Output) in current and future mobile communications relies on accurate channel estimates. In OFDM based systems such as LTE (Long Term Evolution), the channel estimation can be successfully designed with processing in a transform domain, both for uplink and downlink. One such popular transform is to use the IDFT (Inverse Discrete Fourier Transform), window the channel estimate in the time domain and then use DFT to transform back to the frequency domain again. This channel estimate is distorted in the band edges leading to a biased channel estimate. One suggested solution to this problem is to use a DCT (Discrete Cosine Transform) based channel estimator, such that this distortion is reduced. However, as discussed in the current paper, the DCT based channel estimate suffers more from cyclically shifted reference signals, as used for MIMO in LTE for uplink, than the DFT based channel estimator. In order to overcome band edge problems with the DFT based channel estimate, a method is proposed of de-biasing over-sampled DFT based channel estimate by using digital sinc functions. Simulation results indicate that the de-biased DFT based channel estimate is more robust against interference from cyclic shifted reference signals than DCT based channel estimates.
Potentiation of Acetaminophen Hepatotoxicity by Alcohol (1980)

Severe liver failure developed in three chronic alcoholics after they ingested acetaminophen for therapeutic reasons. The clinical course was characterized by SGOT levels of 5,000 to 10,000 IU. Concomitant renal failure developed in two of these patients, and one died in hepatic coma. To determine whether alcohol enhances acetaminophen hepatotoxicity, a lethal dose for 50% survival of a test group (LD50) was performed for mice fed 10% alcohol in their water supply for three weeks and for mice receiving a normal diet only. A significant reduction in the LD50 was seen in the alcohol-pretreated mice, and correlations were noted between histological findings in the liver and the LD50 data. These findings suggest that alcohol enhances acetaminophen hepatotoxicity in mice and provides supportive evidence that these three alcoholic patients probably had a similar pathophysiological basis for their liver disease.
Proteins as Surfactant Enhancers for Environmental and Industrial Applications (2015)

Data are presented on the effect of small proteins on the surface activity of synthetic surfactants and their blends as assessed by standard surface science methods. Surface tension of surfactant solutions, interfacial tension between those solutions and water insoluble substrates, and contact angle between these solutions and a solid surface were determined. It is shown that both small individual proteins, such as lysozyme and -lactoglobulin, as well as proteins in a yeast extract, significantly and predictively reduce critical micelle concentration of multiple widely used surfactants: ionic, non-ionic and amphoteric. Typically, lower minimal interfacial tension could be achieved with a protein synergist, than with the same surfactant in the absence of protein. Examples of industrially important applications of a protein synergist are described. In one of them, the protein accelerates wetting and spreading of surfactant solutions on the hydrophobic surface of green leaves, with concomitant enhancement of the solution uptake by the leaf. In another example, the activity of bacterial lipase, an important industrial enzyme, towards a segregated oil substrate is enhanced by a surfactant-protein synergist blend, as compared to the same surfactant in the absence of a protein synergist.
Normal Arp2/3 complex activation in platelets lacking WASp (2002)

Arp2/3 complex is believed to induce de novo nucleation of actin filaments at the edge of motile cells downstream of WASp family proteins. In this study, the signaling pathways leading to Arp2/3 complex activation, actin assembly, and shape change were investigated in platelets isolated from patients with Wiskott-Aldrich Syndrome (WAS), that is, who lack WASp, and in WASp-deficient mouse platelets. WASp-deficient human and mouse platelets elaborate filopodia, spread lamellae, and assemble actin, identical to control WASp-expressing platelets. Human platelets contain 2 microM Arp2/3 complex, or 8600 molecules/cell. Arp2/3 complex redistributes to the edge of the lamellae and to the Triton X-100-insoluble actin cytoskeleton of activated WASp-deficient platelets. Furthermore, the C-terminal CA domain of N-WASp, which sequesters Arp2/3 complex, inhibits by half the actin nucleation capacity of octylglucoside-permeabilized and activated WAS platelets, similar to its effect in WASp-expressing cells. Along with WASp, platelets express WAVE-2 as a physiologic activator of Arp2/3 complex and a small amount of N-WASp. Taken together, our findings show that platelets activate Arp2/3 complex, assemble actin, and change shape in the absence of WASp, indicating a more specialized role for WASp in these cells.
ChemInform Abstract: 1‐(3‐(DIARYLAMINO)PROPYL)PIPERIDINES AND RELATED COMPOUNDS, POTENTIAL ANTIPSYCHOTIC AGENTS WITH LOW CATALEPTOGENIC PROFILES (1985)

Abstract Die aus (I) zugängliche Verbindung (IV) sowie die ebenfalls synthetisierten Amine (V) werden auf antipsychotische Aktivität getestet.
Reactive polymer processing: Techniques and trends (1984)

Abstract Thermosetting materials are expanding their market penetration owing to their excellent heat resistance and performance characteristics. Energy conservation considerations have also resulted in the development of processing techniques involving the simultaneous polymerization and shaping of the part. The processability of a reactive system is dependent on the thermal and deformation history which is experienced by the material. Despite this processing sensitivity, significant new developments have occurred in recent years including improvements in machinery design, process automation and control, novel processing technology such as RIM and pultrusion, and advances in material formulations. The processing of reactive systems will be considered with emphasis given to the recent developments concerning mathematical analysis and simulation of the process dynamics and the relationship between processing history and part properties.
&lt;title&gt;Effects of water spray and repetition rate on the temperature elevation during Er:YAG laser ablation of dentine&lt;/title&gt; (1996)

The Er:YAG is currently used as an alternative instrument for the removal of dental decay. Safe laser parameters have been found, but in order to increase the preparation speed also higher pulse energies or repetition rates are under consideration. To investigate systematically the temperature effect of these parameters and of water spray, slices of dentine were perforated with the laser radiation, exactly towards a thermocouple placed in a hole at the back side. During and after preparation temperature was monitored, and maximum temperature rise reached at the moment of perforation (T<SUB>m</SUB>) was evaluated. For preparation without water irrigation T<SUB>m</SUB> was in the range of 30 to 40 K, increasing slightly with pulse repetition rate (prr). For low prr (2 Hz) the same was observed for the radiant energy, however for high prr (10 Hz) the effect was inverse. When moistening the slices during preparation by a fine water spray, T<SUB>m</SUB> decreases. The temperature reduction is very pronounced for low prr, leading to a temperature rise of only 2 K at 2 Hz (200 mJ). When prr is enhanced the spray becomes less effective, even when higher flow rates are chosen. With respect to temperature, combinations of low pulse energy and high repetition rate are least favorable. For safe preparations in dentine low pulse repetition rates are recommended.
Follicle-stimulating hormone increases guanine nucleotide-binding regulatory protein subunit alpha i-3 mRNA but decreases alpha i-1 and alpha i-2 mRNA in Sertoli cells. (1992)

FSH interacts with a guanine nucleotide-binding protein (G-protein)-coupled receptor, which in turn modulates signal transduction via the G-protein subunit alpha s. However, it is unknown whether FSH regulates alpha-subunit gene expression and whether G-protein alpha-subunit genes other than alpha s are modulated in FSH-stimulated signal transduction. Regulation of mRNA for alpha s and alpha i-2 was studied in primary cultures of rat Sertoli cells because these proteins are linked to the control of adenylyl cyclase. In addition, mRNA for alpha i-1 and alpha i-3 were quantified because these proteins are putatively linked to ion channels but have not been well characterized in the Sertoli cell. Northern blot analyses demonstrated that FSH induced a dose-dependent increase in steady state levels of alpha i-3 mRNA. In contrast, FSH caused a dose-dependent decrease in levels of alpha i-1 and alpha i-2 mRNA. No significant effect of FSH on alpha s mRNA levels was detectable. The time course of FSH effects showed a 75% decrease in alpha i-1 mRNA levels, a 50% decrease in alpha i-2 mRNA levels and a nearly 3-fold increase in levels of alpha i-3 mRNA between 4-6 h of treatment with 100 ng/ml FSH. Steady state levels of alpha i-1 and alpha i-2 mRNA returned to pretreatment levels after 10 h FSH treatment, while alpha i-3 mRNA returned to a new steady state level approximately 50% greater than the pretreatment level.(ABSTRACT TRUNCATED AT 250 WORDS)
Using Interest Points forRobust Visual Detection and Identification ofObjects inComplex Scenes (2006)

We proposenoveltools thatreducecomplexity andimprove performances ofvisual detection andidentification ofknown objects randomlylocated in complexcluttered environments. Generally, thepropose mechanisms arebasedon local shapefeatures (interest points, visual saliencies) detected in imagesandcharacterized bycompactdescriptors invariant to geometric andphotometric transformations. Inparticular, a novelinvariant forintensity changesisproposed, andthe problemofover-exposed andunder-exposed images isdiscussed. Bothmodelsofknownobjects andimagesofrealscenesare represented usinginterest points, thoughindifferent scales (reference scale formodelsandrelative scale forimages). By matching interest point detected inimages tointerest points from themodeldatabase, knownobjects present inthescenecanbe detected andidentified. Themethodology canbeusedbothfor robot-mounted navigation modulesandfordistributed visual surveillance systems since theproposed mechanisms minimize theamountofvisual datatobetransmitted, thuspreventing communicational saturation ofsuchsystems. Inthepaper, we focusontheimageprocessing aspects oftheproblems. Image acquisition issues andhigh-level identification algorithms are onlybriefly mentioned.
Figure S1 from Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma (2023)

&lt;p&gt;Circos plots for chromosomal rearrangements in adenoid cystic carcinoma.&lt;/p&gt;
The sensitivity of seismic waves to the normal and shear compliance of fractures (2009)

Schoenberg (1980) proposed a model for an imperfectly bonded interface between two elastic media in which the displacement discontinuity is taken to be linearly related to the stress traction that is continuous at the interface. For isotropic interface behavior, there are two interface compliances and , where the displacement discontinuity normal to the interface is given by times the normal stress, and the displacement discontinuity tangential to the interface is given by times the shear stress and acts in the same direction. This model has been widely used to describe the seismic response of fractured reservoirs. Simple asperity deformation models of a fracture suggest that for dry fractures in a rock with low Poisson's ratio. However, more realistic models, which take into account the deformation of the void space between the fracture faces, lead to significant departures of from unity, and the implications of this for the seismic characterization of fractured reservoirs are discussed.
Anesthesia (2019)

The anesthetic care of the left ventricular assist device (LVAD) recipient presents to the anesthesiologist a unique set of challenges which must be skillfully managed for the successful completion of this complex surgical procedure. The anesthesiologist must perform a thorough preoperative evaluation and carefully assess the patient’s cardiovascular, pulmonary, renal, and hepatic systems. Special consideration to the risk of post-implantation right ventricular (RV) dysfunction is critical. In patients with advanced heart failure, a well-formulated anesthetic management plan must be developed to provide adequate anesthesia while at the same time preventing hemodynamic deterioration. The performance of a comprehensive transesophageal echocardiogram study is essential for identifying potential issues that may need to be addressed during the surgery. The post-cardiopulmonary bypass period is fraught with several challenges which the anesthesiologist must address, such as RV dysfunction or failure, vasoplegia, and coagulopathy. The transition of care to the ICU is facilitated by the application of a standardized checklist to ensure that all critical information is conveyed to the critical care providers. The anesthesiologist also frequently provides care for the LVAD patient undergoing a non-cardiac surgery or procedure. A careful preoperative evaluation and a thorough understanding of the technology and physiology of the LVAD patient is essential to the development of a safe and sensible anesthetic management plan.
A Simplified Model for Prediction of HVOF NiCr Coating Properties through Experimental Design and Diagnostic Measurements (2012)

Abstract An empirical model was built for the prediction of HVOF sprayed NiCr in-flight particle properties based on the spraying parameters. The employment of factorial design in process parameter development, allowed determination of the contribution of the key process variables, such as flame energy (combustion pressure and O2/F ratio), spray distance and feed rate, on the resultant particle velocities and surface temperatures. The significance of each parameter was used to compose a simple model which enabled the description of the particles’ in-flight properties. Particles with velocities ranging as much as 300 m/s and temperatures ranging up to 350 °C were used to produce a range of coatings on an in situ curvature sensor enabling the determination of evolving and residual stress. These diverse particle states combined with the effect of flame impingement on the substrate, resulted in coatings of similar thickness, but significantly different stress states. Real time evolving stresses during deposition were interrelated to particle in-flight properties and, consequently, to spraying parameters.
Hardware Trojan horse benchmark via optimal creation and placement of malicious circuitry (2012)

This paper proposes Hardware Trojan (HT) placement techniques that yield challenging HT detection benchmarks. We develop three types of one-gate HT benchmarks based on switching power, leakage power, and delay measurements that are commonly used in HT detection. In particular, we employ an iterative searching algorithm to find rarely switching locations, an aging-based approach to create ultra-low power HT, and a backtracking-based reconvergence identification method to determine the non-observable delay paths. The simulation results indicate that our HT attack benchmarks provide the most challenging representative test cases for the evaluation of side-channel based HT detection techniques.
P450 gene duplication and divergence led to the evolution of dual novel functions and insecticide cross-resistance in the brown planthopper Nilaparvata lugens (2022)

The sustainable control of many highly damaging insect crop pests and disease vectors is threatened by the evolution of insecticide resistance. As a consequence, strategies have been developed that aim to prevent or delay resistance development by rotating or mixing insecticides with different modes of action (MoA). However, these approaches can be compromised by the emergence of mechanisms that confer cross-resistance to insecticides with different MoA. Despite the applied importance of cross-resistance, its evolutionary underpinnings remain poorly understood. Here we reveal how a single gene evolved the capacity to detoxify two structurally unrelated insecticides with different MoA. Using transgenic approaches we demonstrate that a specific variant of the cytochrome P450 CYP6ER1, previously shown to confer resistance to the neonicotinoid imidacloprid in the brown planthopper, N. lugens, also confers cross-resistance to the phenylpyrazole ethiprole. CYP6ER1 is duplicated in resistant strains, and we show that while the acquisition of mutations in two encoded substrate recognition sites (SRS) of one of the parologs led to resistance to imidacloprid, a different set of mutations, outside of known SRS, are primarily responsible for resistance to ethiprole. Epistatic interactions between these mutations and their genetic background suggest that the evolution of dual resistance from the same gene copy involved functional trade-offs in respect to CYP6ER1 catalytic activity for ethiprole versus imidacloprid. Surprisingly, the mutations leading to ethiprole and imidacloprid resistance do not confer the ability to detoxify the insecticide fipronil, another phenylpyrazole with close structural similarity to ethiprole. Taken together, these findings reveal how gene duplication and divergence can lead to the evolution of multiple novel functions from a single gene. From an applied perspective they also demonstrate how cross-resistance to structurally unrelated insecticides can evolve, and illustrate the difficulty in predicting cross-resistance profiles mediated by metabolic mechanisms.
Fast Mapping-Based High-Level Synthesis of Pipelined Circuits (2019)

High level synthesis (HLS) is often employed as a frequently called kernel in design space exploration (DSE). Therefore, its nontrivial runtime becomes a bottleneck that prevents extensive solution search in DSE. In this work, we develop a mapping-based HLS technique that is fast and friendly to local incremental changes. It exploits the static-single assignment (SSA)-form intermediate representation (IR), starts with direct mapping from the IR to a fully pipelined circuit and performs incremental resource sharing in an iterative manner, which then alters the fully pipelined circuit to a partially pipelined or nonpipelined circuit. An algorithm is also proposed for automatic synthesis of pipeline interlocks to avoid structural hazards incurred by resource conflicts. Experimental results show that the proposed method is fast without loss of circuit performance in terms of throughput.
Generation and Rearrangements of Ylides from Tertiary Amines and α-Diazo Ketones − Very High Catalytic Activity of [RuCl(η5-C5H5)(PPh3)2] (2000)

The reaction of N,N-dimethyl-2-propen-1-amine, N,N-dimethylbenzylamine and N,N-dimethyl-2-propyn-1-amine with the α-diazo ketones N2CHCOR [R = Me (2a), Et (2b), nPr (2c), iPr (2d), (CH2)10Me (2e), (CH2)14Me (2f) or Ph (2g)] in a 1:1 molar ratio, catalysed by the complex [RuCl(η5-C5H5)(PPh3)2] (1) (1% mol), have been investigated. Noticeably, the corresponding α-amino ketones 3a−g, 4a−g and 5a−g are readily and quantitatively formed by rearrangement of transient nitrogen ylides. Compounds 3−5, most of which have not yet been reported, have been isolated and fully characterised by IR, 1H and 13C NMR spectroscopy and GC-MS. It has been proved that complex 1 is an excellent and specific catalyst for the generation of nitrogen ylides from diazo carbonyls.
Efficacy and safety of tisagenlecleucel in Japanese adult patients with relapsed/refractory diffuse large B-cell lymphoma (2020)

Tisagenlecleucel showed a high best ORR with a manageable safety profile, thus offering a new treatment option in selected Japanese patients with r/r DLBCL.
Quantitative Analysis of <sup>18</sup>F-(<i>E</i>)-<i>N</i>-(3-Iodoprop-2-Enyl)-2β-Carbofluoroethoxy-3β-(4′-Methyl-Phenyl) Nortropane Binding to the Dopamine Transporter in Parkinson Disease (2015)

(18)F-FE-PE2I is clearly a suitable radioligand for DAT quantification and imaging of the nigrostriatal pathway in PD. Similar metabolism in controls and PD patients, suitability of the cerebellum as a reference region, and accuracy of quantification using approximately 66 min of PET data are advantages for noninvasive and simplified imaging protocols for PD studies. Finally, DAT loss in PD can be measured in both the striatum and the SN, supporting the utility of (18)F-FE-PE2I as an imaging tool of the nigrostriatal pathway.
Redeeming IPC as a performance metric for multithreaded programs (2004)

Recent work has shown that multithreaded workloads running in execution-driven, full-system simulation environments cannot use instructions per cycle (IPC) as a valid performance metric due to nondeterministic program behavior. Unfortunately, invalidating IPC as a performance metric introduces its own host of difficulties: special workload setup, consideration of cold-start and end-effects, statistical methodologies leading to increased simulation bandwidth, and workload-specific, higher-level metrics to measure performance. We explore the nondeterminism problem in multithreaded programs, describe a method to eliminate nondeterminism across simulations of different experimental machine models, and demonstrates the suitability of this methodology for performing architectural performance analysis, thus redeeming IPC as a performance metric for multithreaded programs.