gebhart/patrepeval huggingface dataset:
Increasing reflectivity of the Antarctic ocean‐atmosphere system: Analysis of Total Ozone Mapping Spectrometer (TOMS) and passive microwave data for 1979–1994 (2003)

Measurements of Lambert equivalent reflectance at 380 nm from the Total Ozone Mapping Spectrometer (TOMS) instrument have shown increases in reflectivity between 1979 and 1994 over much of the Southern Ocean, encompassing 280° in longitude. These trends represent a possible change in the state of the Antarctic ocean‐atmosphere system related to recent climate warming. To determine if these reflectivity trends are due to changes in cloud cover or sea ice, or both, the TOMS data were collocated with a contemporaneous passive microwave satellite data set from the scanning multichannel microwave radiometer and the Special Sensor Microwave Imager. The passive microwave data sets specify total sea ice concentration, retrieved by a uniform method for all years using the NASA Team algorithm. To first order the locations of TOMS reflectivity increases coincide with regions where sea ice concentration has increased over the past 2 decades, signifying that the TOMS trends are the result of trends in underlying sea ice and not cloud cover. However, when the TOMS reflectivity measurements are sorted into fixed sea ice concentration bins of 0.1 width, the TOMS data also show increasing reflectivity trends in regions where sea ice extent has been decreasing (Amundsen and Bellingshausen Seas and the Western Antarctic Peninsula). Over open water, TOMS reflectivity trends are less convincing and may be artifacts related to uncertainties in passive microwave sea ice identification. These results suggest that a significant component of the Southern Ocean TOMS reflectivity trends may be a gradual increase in the albedo of the underlying sea ice. This could be caused by a gradual lengthening of the sea ice season, with a concomitant increase in the persistence of dry snow on the sea ice cover.
A finite step adaptive implementation of the Pisarenko's harmonic retrieval method in colored noise (2005)

An adaptive spectral analysis technique is presented for estimating complex frequencies in colored noise. It is assumed that the noise covariance matrix of the colored noise is known. The method presented in this paper is similar to Thompson's technique of an on line estimation of the eigenvector of the covariance matrix corresponding to the minimum eigenvalue, without explicitly evaluating the covariance matrix. The method of conjugate gradient has been utilized to obtain the eigenvector corresponding to the minimum eigenvalue. The advantages of this technique over the method of steepest descent is that it is a finite step iterative method and secondly there is no arbitrary constants in the expression which dictates the overall rate of convergence. In the proposed method, the spread of the eigenvalues has no significant effect on the overall rate of convergence. The disadvantage of this technique is that one has to store a matrix of data instead of one row only, as is conventionally done. The proposed method however yields unbiased estimates for the frequencies in colored noise.
Unite Efforts and Conquer Mysteries of Artificial Genetics (2000)

In his News Focus article “Creation's seventh day” (14 Jul., p. 232), Robert F. Service highlights some recent work in artificial genetics, emphasizing the controversy that might surround “a new life form” and the distinctive personalities of some scientists who have taken up the challenge.
Inhibition of Cell-Cycle Progression in Human Promyelocytic Leukemia HL-60 Cells by MCS-C2, Novel Cyclin-Dependent Kinase Inhibitor (2003)

To elucidate the action mechanism of MCS-C2, a novel analogue of toyocamycin and sangivamycin, its effect on the expression of cell cycle-related proteins in the human myelocytic leukemia cell line HL-60 was examined using Western blotting and a flow cytometric analysis. MCS-C2, a selective inhibitor of cyclin-dependent kinases, was found to inhibit cell growth in a time- and dose-dependent manner, and inhibits cell cycle progression by inducing the arrest at Gl and G2/M phases, in HL-60 cells. The flow cytometric analysis revealed an appreciable arrest of cells in the G2/M phase of the cell cycle after treatment with MCS-C2. The HL-60 cell population increased gradually from 13% at 0 h, to 28% at 12 h in the G2/M phase, after exposure to 2 μM MCS-C2. Furthermore, Western blot analysis demonstrated that MCS-C2 induced the cell cycle arrest at G 1 phase through the inhibition of pRb phosphorylation. Hypophosphorylated pRb accumulated after treatment with 5 μM MCS-C2 for 12 h, whereas, the level of hyperphosphorylated pRb was reduced. Thus, treatment of the cell with MCS-C2 suppressed the hyperphosphorylated form of pRb with a commensurate increase in the hypophosphorylated form.
Data from Molecular Characterization of Choroid Plexus Tumors Reveals Novel Clinically Relevant Subgroups (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; To investigate molecular alterations in choroid plexus tumors (CPT) using a genome-wide high-throughput approach to identify diagnostic and prognostic signatures that will refine tumor stratification and guide therapeutic options.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; One hundred CPTs were obtained from a multi-institutional tissue and clinical database. Copy-number (CN), DNA methylation, and gene expression signatures were assessed for 74, 36, and 40 samples, respectively. Molecular subgroups were correlated with clinical parameters and outcomes.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Unique molecular signatures distinguished choroid plexus carcinomas (CPC) from choroid plexus papillomas (CPP) and atypical choroid plexus papillomas (aCPP); however, no significantly distinct molecular alterations between CPPs and aCPPs were observed. Allele-specific CN analysis of CPCs revealed two novel subgroups according to DNA content: hypodiploid and hyperdiploid CPCs. Hyperdiploid CPCs exhibited recurrent acquired uniparental disomy events. Somatic mutations in &lt;i&gt;TP53&lt;/i&gt; were observed in 60% of CPCs. Investigating the number of mutated copies of p53 per sample revealed a high-risk group of patients with CPC carrying two copies of mutant p53, who exhibited poor 5-year event-free (EFS) and overall survival (OS) compared with patients with CPC carrying one copy of mutant p53 (OS: 14.3%, 95% confidence interval, 0.71%–46.5% vs. 66.7%, 28.2%–87.8%, respectively, &lt;i&gt;P&lt;/i&gt; = 0.04; EFS: 0% vs. 44.4%, 13.6%–71.9%, respectively, &lt;i&gt;P&lt;/i&gt; = 0.03). CPPs and aCPPs exhibited favorable survival.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Discussion:&lt;/b&gt; Our data demonstrate that differences in CN, gene expression, and DNA methylation signatures distinguish CPCs from CPPs and aCPPs; however, molecular similarities among the papillomas suggest that these two histologic subgroups are indeed a single molecular entity. A greater number of copies of mutated &lt;i&gt;TP53&lt;/i&gt; were significantly associated to increased tumor aggressiveness and a worse survival outcome in CPCs. Collectively, these findings will facilitate stratified approaches to the clinical management of CPTs. &lt;i&gt;Clin Cancer Res; 21(1); 184–92. ©2014 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
A Periodic Density Functional Theory and Hartree−Fock Study of Alkali Halides with Gaussian Orbitals (1998)

Periodic-density functional theory (DFT) and Hartree−Fock calculations have been performed on the alkali halides for the alkali metals Li, Na, K, and Rb and the halogens F, Cl, Br and I. Calculations were done with HF-optimized basis sets and DFT-optimized basis sets, at the HF, local DFT (LDFT), and nonlocal DFT (NLDFT) with the Becke exchange potential and the Perdew−Wang correlation potential. The HF and NLDFT results are similar for the lattice parameters, in general, by overestimating them. The LDFT method always underestimates the lattice parameters. As a consequence, the HF and NLDFT methods predict bulk moduli that are too small and the LDFT method predicts bulk moduli that are too large. The absolute error in the bulk moduli are larger at the LDFT level than at the other levels. Charge distribution maps have been calculated and analyzed. The maps clearly show that the main difference between the HF and DFT densities is in the treatment of exchange and that the nonlocal (gradient) corrections moderate this difference.
A wearable system assessing relevant characteristics of the take-off in ski jumping (2012)

Keywords: Ski Jumping, inertial sensors, performance analysis, relevant features, take-off Reference EPFL-CHAPTER-174982 Record created on 2012-02-17, modified on 2017-05-10
An Improved Procedure for the Large Scale Preparation of 2-Chloro-4,6-dimethoxy-1,3,5-triazine (1996)

Abstract A robust process for the preparation of multikilogram quantities of 2-chloro-4,6-dimethoxy-1,3,5-triazine (1) is described.
ChemInform Abstract: REDUCTION OF IRIDOID AGLYCONS. II. REACTIVITY OF LAMIIGENIN TOWARDS SODIUM BOROHYDRIDE (1980)

Abstract In Fortführung an Untersuchungen über die Reaktivität von Iridoid‐ glycosiden gegenüber NaBH 4 wird die Reduktion von Lamiigenin (II) mit NaBH 4 durchgeführt.
Determination of v-Mos-Catalyzed Phosphorylation Sites and Autophosphorylation Sites on MAP Kinase Kinase by ESI/MS (1995)

MAP kinase kinase (MAPKK), a key component of the MAP kinase cascade, is activated through phosphorylation by several protein kinases, including the oncogene v-Mos and its cellular counterpart, c-Mos. The v-Mos-catalyzed phosphorylation sites on recombinant MAPKK1 were identified by electrospray ionization mass spectrometry as S218 and S222, located within a sequence that aligns with the T loop structure of cAMP-dependent protein kinase; these are the same as the Raf-1 phosphorylation site identified previously [Alessi, D. R., et al. (1994) EMBO J. 13, 1610-1619]. Phosphorylation of these sites was kinetically ordered, with S222 preferred over S218. Intramolecular autophosphorylation of these sites was kinetically ordered, with S222 preferred over S218. Intramolecular autophosphorylation of MAPKK occurred at several residues and was increased upon the stimulation of MAPKK activity by v-Mos. Major autophosphorylation sites were residues S298 and Y300. Minor autophosphorylation sites included T23, S299, S218, and either S24 or S25. Sequence similarities were noted between MAPKK autophosphorylation sites and exogenous phosphorylation sites on MAP kinase. Phosphorylation of either S218 or S222 was sufficient for partial MAPKK activation by Mos, and phosphorylation of S222 alone was sufficient for autophosphorylation at S298 and Y300. Mass spectral analysis was also performed on MAPKK1 purified from rabbit skeletal muscle. The peptide containing S218 and S222 was observed in only a singly phosphorylated form, and the peptide containing S298, S299, and Y300 was observed in multiply phosphorylated forms, suggesting that MAPKK is only partially phosphorylated within the T loop but significantly modified in the autophosphorylation loop under physiological conditions.
Pectin-GPTMS-Based Biomaterial: toward a Sustainable Bioprinting of 3D scaffolds for Tissue Engineering Application (2019)

Developing green and nontoxic biomaterials, derived from renewable sources and processable through 3D bioprinting technologies, is an emerging challenge of sustainable tissue engineering. Here, pectin from citrus peels was cross-linked for the first time with (3-glycidyloxypropyl)trimethoxysilane (GPTMS) through a one-pot procedure. Freeze-dried porous pectin sponges, with tunable properties in terms of porosity, water uptake, and compressive modulus, were obtained by controlling GPTMS content. Cell experiments showed that GPTMS did not affect the cytocompatibility of pectin. The addition of GPTMS improved the printability of pectin due to an increase of viscosity and yield stress. Three-dimensional woodpile and complex anatomical-shaped scaffolds with interconnected micro- and macropores were, therefore, bioprinted without the use of any additional support material. These results show the great potential of using pectin cross-linked with GPTMS as biomaterial ink to fabricate patient-specific scaffolds, which could be used to promote tissue regeneration in vivo.
Interleukin 12B (IL12B) Genetic Variation and Pulmonary Tuberculosis: A Study of Cohorts from The Gambia, Guinea-Bissau, United States and Argentina (2011)

We examined whether polymorphisms in interleukin-12B (IL12B) associate with susceptibility to pulmonary tuberculosis (PTB) in two West African populations (from The Gambia and Guinea-Bissau) and in two independent populations from North and South America. Nine polymorphisms (seven SNPs, one insertion/deletion, one microsatellite) were analyzed in 321 PTB cases and 346 controls from Guinea-Bissau and 280 PTB cases and 286 controls from The Gambia. For replication we studied 281 case and 179 control African-American samples and 221 cases and 144 controls of European ancestry from the US and Argentina. First-stage single locus analyses revealed signals of association at IL12B 3' UTR SNP rs3212227 (unadjusted allelic p = 0.04; additive genotypic p = 0.05, OR = 0.78, 95% CI [0.61-0.99]) in Guinea-Bissau and rs11574790 (unadjusted allelic p = 0.05; additive genotypic p = 0.05, OR = 0.76, 95% CI [0.58-1.00]) in The Gambia. Association of rs3212227 was then replicated in African-Americans (rs3212227 allelic p = 0.002; additive genotypic p = 0.05, OR = 0.78, 95% CI [0.61-1.00]); most importantly, in the African-American cohort, multiple significant signals of association (seven of the nine polymorphisms tested) were detected throughout the gene. These data suggest that genetic variation in IL12B, a highly relevant candidate gene, is a risk factor for PTB in populations of African ancestry, although further studies will be required to confirm this association and identify the precise mechanism underlying it.
TGF-β receptor 3 (betaglycan) regulates Th1 differentiation and T dependent B cell responses. (2016)

Abstract TGFβR3, also known as betaglycan, is a co-receptor for the TGFβ receptor and is predicted to have an important function in promoting high affinity binding of TGF-β to TGFβR1 or TGFβR2. TGFβR3 also binds inhibins with high affinity and antagonizes activin dependent activation of SMADs a function independent of TGFβR1/TGFβR2 signaling. Contrary to TGFβR1 and TGFβR2, our knowledge on the role of TGFβR3 in the immune system is very sparse. Its biology has been elusive because the knock-out of Tgfbr3 exhibit embryonic lethality. We developed the first Tgfbr3 f/f mouse in which Cre mediated deletion of Tgfbr3 is very efficient. We found that deletion of TGFβR3 in thymic T cells (Tgfbr3 f/f .CD4Cre) had no effect on CD4 or CD8 double positive (DP) or single positive (SP) T cell populations or peripheral T cell populations. Treg numbers in the thymus and periphery were unaltered and the mice did not develop spontaneous autoimmunity as observed when Tgfbr2 is deleted during thymic development. These observations indicated to us that TGFβR3 likely had a function independent of “classical” TGF-β signaling through TGFβR1/2 receptors. To test for this possibility we generated Tgfbr3 f/f .dLckCre) mice in which is Tgfbr3 is selectively deleted in mature CD4 and CD8 T cells. We found that T dependent Ab responses, particularly of the IgG2c subclass, was greatly enhanced in mice with T-cell restricted loss of TGFβR3. We further determined that the differentiation of naïve CD4 T cells to IFN-γ expressing Th1 cells under polarizing and non-polarizing conditions was enhanced when TGFβR3 was deficient. These and other data indicate that regulation of Th1 differentiation by TGFβR3 is novel and independent of TGF-β signaling.
Reevaluation of steroid tapering after steroid pulse therapy for heart rejection. (1992)

A retrospective analysis was conducted to determine the efficacy and complications resulting from steroid pulse therapy, with or without a steroid taper, in 93 episodes of heart transplant rejection that occurred in 72 patients (58 men, 14 women; mean age, 47.6 years). Each rejection episode was classified according to severity (Texas Heart Institute endomyocardial biopsy scale) and the treatment. Group 1 included 25 episodes of grade 7, 8, 9, or 10 rejection (International Society for Heart Transplantation [ISHT] grade IIIB or IV) that were treated with high-dose methylprednisolone (2.5 to 3.0 gm) and a steroid taper of 1.75 gm over 30 days. Group 2 included 16 episodes of rejection, with the severity of rejection and methylprednisolone pulse therapy being similar to that in group 1, but without a steroid taper. The results of treatment in group 1 were compared with those in group 2. Group 3 included 12 episodes of grade 5, 6, or 7 rejection (ISHT grade IIIA or IIIB) that were treated with moderate-dose methylprednisolone (1.0 to 2.0 gm) and a steroid taper, as described. Group 4 included 40 episodes of rejection, with the severity of rejection and methylprednisolone therapy being similar to that of group 3, but without a steroid taper. The results of treatment in group 3 were compared with those in group 4. No statistically significant differences were found among the groups regarding subsequent episodes of rejection or infection within 3 months of treatment. No statistically significant difference was noted among the groups in the number of rejection episodes requiring additional therapy to control the rejection.(ABSTRACT TRUNCATED AT 250 WORDS)
Competitive Resource Allocation in HetNets: the Impact of Small-cell Spectrum Constraints and Investment Costs (2017)

Heterogeneous wireless networks with small-cell deployments in licensed and unlicensed spectrum bands are a promising approach for expanding wireless connectivity and service. As a result, wireless service providers (SPs) are adding small-cells to augment their existing macro-cell deployments. This added flexibility complicates network management, in particular, service pricing and spectrum allocations across macro- and small-cells. Further, these decisions depend on the degree of competition among SPs. Restrictions on shared spectrum access imposed by regulators, such as low power constraints that lead to small-cell deployments, along with the investment cost needed to add small cells to an existing network, also impact strategic decisions and market efficiency. If the revenue generated by small-cells does not cover the investment cost, then there will be no deployment even if it increases social welfare. We study the implications of such spectrum constraints and investment costs on resource allocation and pricing decisions by competitive SPs, along with the associated social welfare. Our results show that while the optimal resource allocation taking constraints and investment into account can be uniquely determined, adding those features with strategic SPs can have a substantial effect on the equilibrium market structure.
Novel approaches and challenges to treatment of central nervous system viral infections (2013)

Existing and emerging viral central nervous system (CNS) infections are major sources of human morbidity and mortality. Treatments of proven efficacy are currently limited predominantly to herpesviruses and human immunodeficiency virus (HIV). Development of new therapies has been hampered by the lack of appropriate animal model systems for some important viruses and by the difficulty in conducting human clinical trials for diseases that may be rare, or in the case of arboviral infections, often have variable seasonal and geographic incidence. Nonetheless, many novel approaches to antiviral therapy are available, including candidate thiazolide and pyrazinecarboxamide derivatives with potential broad-spectrum antiviral efficacy. New herpesvirus drugs include viral helicase-primase and terminase inhibitors. The use of antisense oligonucleotides and other strategies to interfere with viral RNA translation has shown efficacy in experimental models of CNS viral disease. Identifying specific molecular targets within viral replication cycles has led to many existing antiviral agents and will undoubtedly continue to be the basis of future drug design. A promising new area of research involves therapies based on enhanced understanding of host antiviral immune responses. Toll-like receptor agonists and drugs that inhibit specific cytokines as well as interferon preparations have all shown potential therapeutic efficacy. Passive transfer of virus-specific cytotoxic T lymphocytes has been used in humans and may provide an effective therapy for some herpesvirus infections and potentially for progressive multifocal leukoencephalopathy. Humanized monoclonal antibodies directed against specific viral proteins have been developed and in several cases evaluated in humans in settings including West Nile virus and HIV infection and in pre-exposure prophylaxis for rabies.
Sound transmission in mass timber floor-ceiling assemblies (2020)

As mass timber structures become more commonly used in the United States, laboratory acoustical data is needed to guide the design of these buildings. In the fall of 2019, a laboratory test program of airborne isolation per ASTM E90 and impact isolation per ASTM E492 of mass timber floor-ceiling assemblies was undertaken. Cross Laminated Timber (CLT), Dowel Laminated Timber (DLT) and Mass Plywood Panel (MPP) panel types were tested with ceiling conditions selected based on 2021 IBC fire code requirements. Comparisons will be made between panel types and other contemporary building types using broadband, low, and high frequency metrics.
Computation Offloading and Resource Allocation in F-RANs: A Federated Deep Reinforcement Learning Approach (2022)

The fog radio access network (F-RAN) is a promising technology in which the user mobile devices (MDs) can offload computation tasks to the nearby fog access points (F-APs). Due to the limited resource of F-APs, it is important to design an efficient task offloading scheme. In this paper, by considering time-varying network environment, a dynamic computation offloading and resource allocation problem in F-RANs is formulated to minimize the task execution delay and energy consumption of MDs. To solve the problem, a federated deep reinforcement learning (DRL) based algorithm is proposed, where the deep deterministic policy gradient (DDPG) algorithm performs computation offloading and resource allocation in each F-AP. Federated learning is exploited to train the DDPG agents in order to decrease the computing complexity of training process and protect the user privacy. Simulation results show that the proposed federated DDPG algorithm can achieve lower task execution delay and energy consumption of MDs more quickly compared with the other existing strategies.
Group A Streptococcal Necrotizing Fasciitis Following Varicella in Children: Case Reports and Review (1995)

We report four cases of necrotizing fasciitis that occurred following varicella in children ranging in age from 2 to 8 years. The only organism isolated from each of these patients was Streptococcus pyogenes or group A beta-hemolytic Streptococcus (GABHS). Each child recovered; however, three required repeated surgical debridements in addition to therapy with antibiotics. An interesting finding in these patients was the development of hyponatremia and/or hypocalcemia. M-typing and T-typing of the isolates demonstrated that the GABHS strain in two children who attended the same school was M5; M1 and M3 strains were identified in the other two children. In addition to the children described in this series, eleven other cases of children with necrotizing fasciitis following varicella have been reported in the English-language literature since 1970. We believe that these cases provide further evidence that varicella is an important risk factor for necrotizing fasciitis that is caused by more-virulent strains of GABHS.
Supplementary Figure 6 from Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma (2023)

&lt;p&gt;PDF file - 820K, Full length images of all Western blots presented&lt;/p&gt;