gebhart/patrepeval huggingface dataset:
Hypersensitive Response to Over‐reactive Cysteines (2011)

Finding the active cysteine in a hay stack: In the search for active proteins and active-site peptides in a proteome, techniques such as quantitative proteomics and protein profiling with activity-based probes (ABPs; see picture) are commonly used. A recently developed proteomics technique combines these approaches to globally identify reactive cysteines, and possibly other amino acids, in a complex proteome.
QoS in switched Industrial Ethernet (2009)

As Industrial Ethernet evolves it will increasingly include integration with the ¿IT network¿ in order to utilize the benefits which the use of Ethernet provides. This will result in a mixed protocol environment also in the industrial networks, which in turn will require proper usage of QoS in order to maintain the demanding requirements of latency, jitter and packet loss in the Industrial Ethernet protocols. This paper highlights the emerging need for using QoS as well as some other related technologies in Industrial Ethernet networks and outlines some guidelines to achieve well-performing networks and efficient communication both for real-time control data and other less time critical data.
New Role for Interleukin‐13 Receptor α1 in Myocardial Homeostasis and Heart Failure (2017)

The results of our studies in humans and mice indicate, for the first time, a role of interleukin-13 receptor α1 in myocardial homeostasis and heart failure and suggests a new therapeutic target to treat heart disease.
Maternal obesity and pregnancy outcome. (2000)

Obese pregnant women are at high risk for complications during delivery and therefore need careful pre-conception and prenatal counseling, as well as perinatal management.
The NLRP3 inflammasome inhibitor OLT1177 rescues cognitive impairment in a mouse model of Alzheimer’s disease (2020)

Numerous studies demonstrate that neuroinflammation is a key player in the progression of Alzheimer's disease (AD). Interleukin (IL)-1β is a main inducer of inflammation and therefore a prime target for therapeutic options. The inactive IL-1β precursor requires processing by the the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome into a mature and active form. Studies have shown that IL-1β is up-regulated in brains of patients with AD, and that genetic inactivation of the NLRP3 inflammasome improves behavioral tests and synaptic plasticity phenotypes in a murine model of the disease. In the present study, we analyzed the effect of pharmacological inhibition of the NLRP3 inflammasome using dapansutrile (OLT1177), an oral NLRP3-specific inhibitor that is safe in humans. Six-month-old WT and APP/PS1 mice were fed with standard mouse chow or OLT1177-enriched chow for 3 mo. The Morris water maze test revealed an impaired learning and memory ability of 9-mo-old APP/PS1 mice (<i>P</i> = 0.001), which was completely rescued by OLT1177 fed to mice (<i>P</i> = 0.008 to untreated APP/PS1). Furthermore, our findings revealed that 3 mo of OLT1177 diet can rescue synaptic plasticity in this mouse model of AD (<i>P</i> = 0.007 to untreated APP/PS1). In addition, microglia were less activated (<i>P</i> = 0.07) and the number of plaques was reduced in the cortex (<i>P</i> = 0.03) following NLRP3 inhibition with OLT1177 administration. We also observed an OLT1177 dose-dependent normalization of plasma metabolic markers of AD to those of WT mice. This study suggests the therapeutic potential of treating neuroinflammation with an oral inhibitor of the NLRP3 inflammasome.
An Oral DNA Vaccine Encoding Endoglin Eradicates Breast Tumors by Blocking Their Blood Supply (2006)

Abstract : In an effort to meet the urgent need for the development of novel and effective treatments for metastatic breast cancer, we developed and evaluated a novel, oral DNA vaccine targeting endoglin (CD105). This target molecule, overexpressed on proliferating endothelial cells in the breast tumor neovasculature, proved most efficacious as this vaccine specifically activated antigen-presenting dendritic cells (DCs), induced effective immune responses by CD8+ T cells against endoglin-positive target cells and markedly suppressed tumor angiogenesis. We could prove by in vivo immunodepletions that the vaccine, delivered by gavage with attenuated Salmonella typhimurium to Peyer's patches in the small intestine, specifically activated CD11c+ OCs and their costimulatory molecules CD8O and CD86 as well as CD8+ T cells. Together, these effects led to a strong suppression of pulmonary metastases of D2F2 breast carcinoma cells in a syngeneic mouse tumor model. It is anticipated that this new vaccine strategy can be translated to clinical application to evaluate its use for the treatment of breast cancer.
Metamorphosis of an Enzyme (2009)

A surprisingly large enzyme complex was isolated and purified from the cell contents of Bacillus subtilis in 1980 at the technical University of Munich (1, 26).The complex, which was initially called "heavy riboflavin synthase", was a 10 6 Dalton protein (26 S) that consisted of two types of subunits, which were designated as (M = 23500 Da) and (M = 16000 Da).It was found that the enzyme catalysed two subsequent reactions of the riboflavin biosynthesis pathway, shown in Fig. 1 (31).At this time, the second substrate 2 was still unknown, but a four carbon compound was suggested (36).The molecular structure of "heavy riboflavin synthase" showed a number of unexpected features.The subunit stoichiometry was striking with 3 subunits and 60 subunits.Electron micrographs obtained by negative staining showed approximately spherical particles with a diameter of 150 , shown in Fig. 2 (5).Binding experiments with antibodies raised against subunits showed that the immunological determinants of the subunits were inaccessible in the native enzyme complex (3).On the basis of these preliminary results, it was suggested that the quaternary structure of the bifunctional enzyme complex is characterized as a spherical capsid of 60 subunits with icosahedral symmetry, which contains a trimer of subunits in the central cavity (5).Fig. 1.Reaction catalyzed by the bifunctional lumazine synthase (A) riboflavin synthase (B) complex
Surface shape measurement for a multilayered object by synthesis of optical coherence function (2000)

An interferometric system is proposed by synthesis of the optical coherence function for measuring surface shapes of multiple planes in a multilayered transparent object. By stepwise optical frequency modulation of a laser source, the system synthesizes the optical coherence function into a delta function-like peak at an arbitrary depth, and the depth of the peak can be adjusted by changing the frequency modulation parameter. In this way, the interference of a reference with the reflection at each target surface can be selectively extracted, and the shapes of the target surfaces can then be obtained by means of fringe analysis such as the Fourier transform (FT) method. An experimental demonstration is presented and performance degradation factors are discussed.
Pre-sorted multiple-branch successive interference cancelation detection for high-dimensional MIMO systems (2012)

In multiple-input multiple-output (MIMO) systems, the maximum likelihood detection (MLD) can obtain the maximum receive diversity order while its computational complexity grows exponentially with the number of constellation points and the transmitted streams. Lattice reduction (LR)-aided detection can parallel the diversity order of MLD with low complexity; however, its performance gap to MLD becomes wider with the increase of the system dimension that is expected with very large MIMO systems. In this paper, pre-sorted multiple-branch successive interference cancelation (PS-MB-SIC) detection techniques are proposed. Simulation results show that the proposed algorithm can approach the diversity order of MLD with much lower complexity and is suited to high-dimensional MIMO systems.
Point-scanning two-photon microscopy at multi-kilohertz frame rate (2022)

Get PDF Email Share Share with Facebook Tweet This Post on reddit Share with LinkedIn Add to CiteULike Add to Mendeley Add to BibSonomy Get Citation Copy Citation Text S. Xiao and J. Mertz, "Point-scanning two-photon microscopy at multi-kilohertz frame rate," in Biophotonics Congress: Biomedical Optics 2022 (Translational, Microscopy, OCT, OTS, BRAIN), Technical Digest Series (Optica Publishing Group, 2022), paper MM4A.5. Export Citation BibTex Endnote (RIS) HTML Plain Text Citation alert Save article
Coatings with barrier layers for extreme‐short wavelengths (2021)

Summary Over the last few decades, remarkable progress has been made in the field of multilayer coatings for the EUV spectral region, mainly due to the demands of EUV lithography for the semiconductor industry. The progress is associated with a deep understanding of the multilayer film growth, application of advanced smoothing technologies for multilayer interfaces, as well as the development of modern deposition and characterization techniques. The projection optics precisely coated by Mo/Si mirrors with 70 % reflectivity is the heart of the performance of industrial EUVL steppers recently developed by ASML for high‐volume chip production. While the EUVL at 13.5 nm has just launched into the market, the first high‐performance LaN/B multilayer mirrors with reflectivity up to 61 % were developed for the next emerging lithography generation with a reduced wavelength of 6.6 nm. Recent technological progress in EUVL optics and radiation sources triggered the development of compact microscopes in the water window spectral range (2.4 – 4.4 nm). The optimization of the multilayer design and deposition process of Cr/V, Cr/Sc and Cr/C mirrors resulted in reflectivity of 14.5% at 2.42 nm, 27.0 % at 3.16 nm, and 15,6% at a wavelength of 4.42 nm, respectively. These promising and still not limiting results indicate a large potential for future application of multilayer coated optics in various application fields such as microscopy in the water window, plasma diagnostics, spectroscopy, and astrophysics.
Table S1 from Proteomic Analysis of CSF from Patients with Leptomeningeal Melanoma Metastases Identifies Signatures Associated with Disease Progression and Therapeutic Resistance (2023)

&lt;p&gt;TMT Batch Setup&lt;/p&gt;
EEG Detection of Early Alzheimer's Disease Using Psychophysical Tasks (2005)

In this study, we hypothesized that a quantitative EEG (qEEG) method for measuring EEG variability combined with specific psychophysical tasks could improve the classification accuracy of subjects with normal aging vs. mild cognitive impairment (MCI) or mild dementia due to Alzheimer's Disease and Related Disorders (ADRD). The cross-sectional sample consisted of 48 subjects (32 normal aging and 16 ADRD: n = 3 mild dementia, n = 13 MCI FAST stage 3). During EEG recording, subjects performed two visual, delayed recognition memory tasks as well as a task that tested their ability to perceive structure-from-motion (SFM). These EEG data were used to compute qEEG measures of the (normalized) variance of posterior cortical activity during the first 150 milliseconds (ms) after stimulus onset and the variance of anterior cortical activity during the second 150 ms epoch. The ratio, anterior/posterior cerebral qEEG value, was then computed for each subject, and the optimal cutoff value identified to discriminate normal from impaired subjects. An optimal qEEG cutoff value for the delayed recognition memory tasks correctly discriminated 30 of the 32 normal aging subjects (94% specificity) and 14 of 16 MCI-to-mild ADRD subjects (88% sensitivity). On the other hand, the application of this qEEG measure to EEG data recorded while subjects performed a SFM task did not distinguish between ADRD and normal aging any better than chance. In conclusion, this qEEG measure is specific to the psychophysical task being performed by the subject. When it was combined with delayed recognition memory tasks, it yielded results that are comparable to the accuracies reported by PET scan studies of normal aging vs. AD with mild cognitive impairment. These results warrant further evaluation.
In silico analysis of the cyclophilin repertoire of apicomplexan parasites (2009)

The genomes of apicomplexa harbor a cyclophilin repertoire that is at least as complex as that of most fungi. The identification of Cyp subfamilies that are specific for lower eukaryotes, apicomplexa, or even the genus Plasmodium is of particular interest since these subfamilies are not present in host cells and might therefore represent attractive drug targets.
Investigation of Hysteresis Phenomenon in Floating-Gate NAND Flash Memory Cells (2015)

The origin of hysteresis phenomenon in floating-gate (FG) NAND flash memory cells in cell strings was identified. To analyze the hysteresis phenomenon in FG NAND flash memory strings, pulsed I-V and fast transient bitline current (I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BL</sub> ) measurements were used in this study. It was found that the hysteresis phenomenon is originated by traps in the bottom oxide of the oxide/nitride/oxide interpoly dielectric. When the control-gate voltage (V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CG</sub> ) of a selected cell in the erased state is 5 V, the electrons in the FG are captured in the traps, because the trap energy level (ET) is lower than the Fermi energy level (E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">F</sub> ) of the FG (E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> - E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">F</sub> <; 0), which leads to the increase in I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BL</sub> . When the V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">CG</sub> of the selected cell is V <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">th</sub> , trapped electrons are emitted to the FG, because the E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> is higher than the E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">F</sub> of the FG (E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">T</sub> - E <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">F</sub> > 0), which leads to the decrease in I <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">BL</sub> .
Quality of life detriments through self-reported swelling associated with gynaecological cancer (2012)

Background and objectives: Lower limb lymphoedema is a serious and feared sequelae after treatment for gynaecological cancer. Given the limited prospective data on incidence of and risk factors for lymphoedema after treatment for gynaecological cancer we initiated a prospective cohort study in 2008.Methods: Overall, 378 women were assessed before treatment and at regular intervals after treatment for two years. Followup visits were grouped into time periods of 6 week - 3 months (time 1), 6 months – 12 months (time 2), and 15 months - 24 months (time 3). Preliminary data analysis was undertaken using generalised estimating equations to model the repeated measures data of Functional Assessment of Cancer Therapy-General (FACT-G) quality of life (QoL) scores and self-reported swelling at each follow-up visit period (best-fitting covariance structure).Results: The QOL of those with self-reported swelling was clinically lower at all time periods, compared with those who did not have swelling (Mean (SD) FACTG scores at time 1, 2 and 3 were 83 (15), 82 (17) and 85 (15), respectively, for those with swelling and 88 (15), 93 (13), 91 (15), respectively, for those without swelling, p<0.01). While QOL remained largely stable among those with swelling between time 1 and 2, QoL improved in women who did not self-report swelling.Conclusions: Lower-limb swelling adversely influences QOL and change in QoL overtime in patients after treatment for gynaecological cancer.
Corrigendum: Imaging Protein Misfolding in the Brain Using β-Sheet Ligands (2018)

[This corrects the article DOI: 10.3389/fnins.2018.00585.].
Iterative detection for Walsh-Hadamard transformed OFDM (2004)

In this paper, an iterative detection method is proposed to reduce the noise enhancement in Walsh-Hadamard transformed (WHT)-OFDM system. The iterative detection starts with conventional detection. The estimation of the received signal at the weakest subcarrier is calculated based on the detection of all data symbols after the hard decision or a combination of hard decision with soft decision, such as utilizing a clipping function. Then the actual received signal at the weakest subcarrier is replaced by the estimated signal and the conventional detection is applied repeatedly to replace the next weakest signal until all subcarriers are replaced. Through replacing the real subcarrier signal with the less noisy estimated signal one by one, iteratively, we can reduce the noise amplification significantly and smoothly. It is seen in the simulations, the bit error rate performance of the iterative detection is much better than that of the conventional detection for either WHT-OFDM system or OFDM system.
Ahmed and Baerveldt glaucoma drainage implants: long-term results and factors influencing outcome. (2009)

Ahmed and Baerveldt implants are a safe and effective procedure for lowering the IOP in the management of refractory glaucoma.
Using native and syntenically mapped cDNA alignments to improve <i>de novo</i> gene finding (2008)

AUGUSTUS is open source and available at http://augustus.gobics.de. The gene predictions for human can be browsed and downloaded at the UCSC Genome Browser (http://genome.ucsc.edu).
Compression of High-Charge Electron Bunches (2000)

The A0 Photoinjector at Fermilab can produce high charge (10-14 nC) electron bunches of low emittance (20 pi mm-mrad for 12 nC). We have undertaken a study of the optimal compression conditions. Off-crest acceleration in the 9-cell capture cavity induces an energy-time correlation, which is rotated by the compressor chicane (4 dipoles). The bunch length is measured using streak camera images of optical transition radiation. We present measurements under various conditions, including the effect of the laser pulse length (2 ps sigma Gaussian vs. 10 ps FWHM flat top). The best compression to date is for a 13.2 nC bunch with sigma = 0.63 mm (1.89 ps), which corresponds to a peak current of 2.8 kA.
Effluent pH correlates with electrochemical nitrogen recovery efficiency at pilot scale operation (2022)

A bipolar electrodialysis (BP-ED) pilot plant including 3.15 m2 of cation exchange membrane and bipolar membrane each was operated for ammonia recovery. The pilot treated source-separated diluted urine (1 gNH4+/L). Previously found set operation parameters for lab-scale such as current density and nitrogen load did not directly influence the stack performance. However, the effluent pH was directly related to the removal efficiency of the system. 80% nitrogen removal was achieved at a set effluent pH of 4. Operating under an effluent pH control strategy was more effective to control NH4+ removal than controlling current density or nitrogen loading, as it accounts for fluctuation in wastewater availability and composition. The pilot plant removed up to 88% of the NH4+ from urine and recovered around 700 g/day (from 1 m3 of urine). This was a significant improvement compared to the pilot plant previous performance on digestate. The energy consumption was around 13 Wh/gN. The overall current efficiency was ∼40% with most losses caused by parasitic ionic shortcut currents occurring at the hydraulic manifolds of the BP-ED stack. Therefore, the energy demand can be further decreased by preventing these ionic shortcuts in the new cell designs.
126-OR: Metformin Discontinuation and Clinical Outcomes in Patients with Diabetes and Advanced Chronic Kidney Disease—A Prospective Cohort Study (2023)

Introduction: Metformin can now be used in patients with chronic kidney disease (CKD) up to estimated glomerular filtration rate [eGFR] ≥30 ml/min/1.73m2. However, surveys suggested its continuing use in some patients with eGFR&amp;lt;30 ml/min/1.73m2 in real world practice although the risk-benefit ratios remain uncertain. Methods: This was a prospective, population-based cohort of 36,940 patients with diabetes in Hong Kong stratified by continuation of metformin within 6 months after reaching eGFR&amp;lt;30 ml/min/1.73m2 in 2002-2018, followed up until 2019. We used Cox model with time-dependent exposure and covariates to estimate the hazard ratio (HR) of death, major-adverse cardiovascular events (MACE), and end-stage kidney disease (ESKD) in a propensity-score overlap-weighted cohort of continued versus discontinued-metformin users. Results: Of 36,940 metformin users with new-onset eGFR&amp;lt;30 ml/min/1.73m2, 8400 (22.7%) discontinued metformin within 6 months whereas 28,540 (77.3%) continued with metformin. The median metformin daily dose was 1000 [interquartile range, IQR: 1000, 1000] mg in continued-metformin users. During a median follow-up of 3.5 (IQR:1.8-5.8) years, 15.3%, 16.6%, and 28.1% had incident MACE, heart failure, and ESKD respectively, and 41.5% died. Compared to continued-metformin use, discontinuation was associated with higher risk of MACE (weighted and adjusted HR=1.42, 95% CI: 1.31-1.54), heart failure (HR=1.70, 1.58-1.83), ESKD (HR=1.73, 1.63-1.83), and death (HR=1.24, 1.19-1.29). Results were consistent in patients with and without established cardiovascular diseases (CVD). Conclusions: Discontinuation of metformin was associated with increased risk of cardiovascular-renal events, regardless CVD status. Continuation of metformin below eGFR 30ml/min/1.73m2 may be associated with cardio-renal and mortality benefits that needs to be weighed against the risks of lactic acidosis. Disclosure A.Yang: None. R.C.Ma: Advisory Panel; AstraZeneca, Merck &amp; Co., Inc., Other Relationship; Bayer Inc., Boehringer-Ingelheim, Research Support; Tricida, Inc., Roche Diagnostics, Novo Nordisk. J.C.Chan: Board Member; Asia Diabetes Foundation, Consultant; Bayer Inc., Celltrion, Boehringer Ingelheim and Eli Lilly Alliance, Sanofi, Research Support; AstraZeneca, Servier Laboratories, Viatris Inc., Hua Medicine, Merck KGaA, Applied Therapeutics Inc., Lee Powder, Pfizer Inc., Speaker's Bureau; Novartis, Stock/Shareholder; GemVCare Ltd. E.Chow: Research Support; Medtronic, Merck KGaA, Speaker's Bureau; Novartis, Bayer Inc., Sanofi. M.Shi: None. H.Wu: None. E.S.H.Lau: None. J.T.K.Cheung: None. X.Zhang: None. B.Fan: None. A.P.Kong: Advisory Panel; Abbott, Kyowa Kirin Co., Ltd., Speaker's Bureau; Abbott, AstraZeneca, Lilly, Bayer Inc., Boehringer Ingelheim Inc. A.Luk: Research Support; Novo Nordisk, Boehringer-Ingelheim, Bayer Inc., Speaker's Bureau; Eli Lilly and Company. Funding Chinese University of Hong Kong
Antiinflammatory Activity of .ALPHA.-Hederin Methyl Ester from the Alkaline Hydrolysate of the Butanol Fraction of Kalopanax pictus Bark Extract. (2003)

Three antiinflammatory saponin components were isolated from the alkaline hydrolysate of a butanol-soluble portion of Kalopanax pictus bark extract through an in vivo activity-guided fractionation procedure. The hydrolysate showed inhibition of adjuvant induced arthritis in rats. After further fractionation, the ethyl acetate fraction exhibited antiarthritic activity, which resulted in the isolation of α-hederin, α-hederin methyl ester, and kalopanaxsaponin I. All compounds showed inhibition of vascular permeability in mice, but only α-hederin methyl ester showed anticarrageenan activity in rats and antiarthritic activity in rats and mice.