gebhart/patrepeval huggingface dataset:
Technical Note—A Note on Relaxations of the Choice Network Revenue Management Dynamic Program (2016)

In recent years, several approximation methods have been proposed for the choice network revenue management problem. These approximation methods are proposed because the dynamic programming formulation of the choice network revenue management problem is intractable even for moderately sized instances. In this paper, we consider three approximation methods that obtain upper bounds on the value function, namely, the choice deterministic linear program (CDLP), the affine approximation (AF), and the piecewise-linear approximation (PL). It is known that the piecewise-linear approximation bound is tighter than the affine bound, which in turn is tighter than CDLP. In this paper, we prove bounds on how much the affine and piecewise-linear approximations can tighten CDLP. We show (i) the gap between the AF and CDLP bounds is at most a factor of [Formula: see text], where [Formula: see text] are the resource capacities, and (ii) the gap between the piecewise-linear and CDLP bounds is within a factor of 2. Moreover, we show that these gaps are essentially tight. Our results hold for any discrete-choice model and do not involve any asymptotic scaling. Our results are surprising because calculating the AF bound is NP-hard and CDLP is tractable for a single-segment multinomial logit model; our result implies that if a firm has all resource capacities of 100, the gap between the two bounds, however, is at most 1.01.
Petroleum Data Analytics (2018)

The realization that much value can be extracted from the data routinely collected during drilling, completion, stimulation, workover, injection, and production operations in the upstream exploration and production industry has resulted in a growing interest in the application of data-driven analytics in the industry. Petroleum data analytics is the application of data-driven analytics and big data analytics in the upstream oil and gas industry. Data mining and machine learning techniques must be used in order to deduce information and knowledge from the raw data that resides in the databases. Data mining has been able to attract the attention of many in the fields of scientific research, business, the banking sector, intelligence agencies, and many others from the early days of its inception. Data mining is used in the banking sector for credit card fraud detection by identifying the patterns involved in fraudulent transactions. It is also used to reduce credit risk by classifying a potential client and predicting bad loans.
Product Element Sensitivity Measurement Under Multiple Exogenous Uncertainties Considering Change Propagation Behavior (2016)

In the flexible design for a complex product, it's necessary to identify the product element's sensitivity to multiple exogenous uncertainties at initial design stage. In the traditional method, relation transitivity is a basic assumption in the change propagation network. This assumption is not always a realistic situation in the product system design. In order to make the sensitivity parameter better reflect the change propagation behavior, this paper provides a sensitivity identification method based on the Multi-Domain Matrix (MDM). A change attenuation parameter is introduced, and the combined influence matrix of the MDM is obtained using the powers of the MDM. Based on the combined influence matrix, the sensitivity value of a product element to all exogenous factors is obtained. A case study on the design of a High Speed Rail (HSR) system is used to illustrate the application of this approach. Results show that the proposed approach can identify the sensitivity of a product element more reasonably.
Methane absorption spectroscopy on a silicon photonic chip (2017)

Infrared tunable diode-laser absorption spectroscopy (IR-TDLAS) is an enabling technology for trace-gas detection, with applications ranging from air-quality monitoring to medical diagnostics. However, such sensors typically utilize discrete optical components that pose practical cost limits for large-scale network deployments. Here, we leverage silicon photonics technology to demonstrate IR-TDLAS on an integrated CMOS-compatible platform for methane (CH4) spectroscopy. Using near-IR (1650 nm) light from a distributed-feedback laser and an uncooled InGaAs detector, the evanescent optical field of a high-index contrast nanoscale silicon waveguide is used to probe ambient CH4, yielding Gaussian-noise-limited sub-100 parts-per-million by volume detection limits. Our results demonstrate the feasibility of chip-scale photonic integration for realizing compact, cost-effective, and versatile gas sensors capable of tackling diverse energy and environmental challenges, such as natural-gas leak quantification and localization for fugitive-emissions monitoring.
Three-dimensional Nuclear Telomere Architecture Is Associated with Differential Time to Progression and Overall Survival in Glioblastoma Patients (2010)

The absence of biological markers allowing for the assessment of the evolution and prognosis of glioblastoma (GBM) is a major impediment to the clinical management of GBM patients. The observed variability in patients' treatment responses and in outcomes implies biological heterogeneity and the existence of unidentified patient categories. Here, we define for the first time three GBM patient categories with distinct and clinically predictive three-dimensional nuclear-telomeric architecture defined by telomere number, size, and frequency of telomeric aggregates. GBM patient samples were examined by three-dimensional fluorescent in situ hybridization of telomeres using two independent three-dimensional telomere-measurement tools (TeloView program [P(1)] and SpotScan system [P(2)]). These measurements identified three patients categories (categories 1-3), displaying significant differences in telomere numbers/nucleus (P(1) = .0275; P(2) <or= .0001), telomere length (P(1) and P(2) = .0275), and number of telomeric aggregates (P(1) = .0464; P(2) <or= .0001). These categories corresponded to patients with long-term, intermediate, and short-term survival, respectively (P = .0393). The time to progression analyses showed significant differences between the three categories (P = .0167). There was a correlation between time to progression, median survival, and nuclear telomere architecture. Our study suggests a link between patient outcome and three-dimensional nuclear-telomere organization and highlights the potential clinical power of telomere signatures as a new prognostic, predictive, and potentially pharmacodynamic biomarker in GBM. Furthermore, novel automated three-dimensional high-throughput scanning as developed here permits to obtain data from 300 nuclei in 20 minutes. This method is applicable to any cell type and scanning application.
Heterogeneity of amplification of HER2, EGFR, CCND1 and MYC in gastric cancer (2015)

The data of our study demonstrate that heterogeneity is common for biomarkers in gastric cancer. Given that both TMA tissue cores and clinical tumor biopsies analyze only a small fraction of the tumor bulk, it can be concluded that such heterogeneity may potentially limit treatment decisions based on the analysis of a single clinical cancer biopsy.
Phase Change Material Selection for Thermal Energy Storage at High Temperature Range between 210 °C and 270 °C (2018)

The improvement of thermal energy storage systems implemented in solar technologies increases not only their performance but also their dispatchability and competitiveness in the energy market. Latent heat thermal energy storage systems are one of those storing methods. Therefore, the need of finding the best materials for each application becomes an appealing research subject. The main goal of this paper is to find suitable and economically viable materials able to work as phase change material (PCM) within the temperature range of 210–270 °C and endure daily loading and unloading processes in a system with Fresnel collector and an organic Rankine cycle (ORC). Twenty-six materials have been tested and characterized in terms of their thermophysical conditions, thermal and cycling stability, and health hazard. Two materials out of the 26 candidates achieved the last stage of the selection process. However, one of the two finalists would require an inert working atmosphere, which would highly increase the cost for the real scale application. This leads to a unique suitable material, solar salt (40 wt % KNO3/60 wt % NaNO3).
Deciphering the consequence of deep intronic variants: a progeroid syndrome caused by a <i>TAPT1</i> mutation is revealed by combined RNA/SI-NET sequencing (2022)

ABSTRACT Exome sequencing has introduced a paradigm shift for the identification of germline variations responsible for Mendelian diseases. However, non-coding regions, which make up 98% of the genome, cannot be captured. The lack of functional annotation for intronic and intergenic variants makes RNA-seq a powerful companion diagnostic. Here, we illustrate this point by identifying six patients with a recessive Osteogenesis Imperfecta (OI) and neonatal progeria syndrome. By integrating homozygosity mapping and RNA-seq, we delineated a deep intronic TAPT1 mutation (c.1237-52G&gt;A) that segregated with the disease. Using patients’ fibroblasts, we document that TAPT1’s nascent transcription was not affected, indicating instead that this variant leads to an alteration of pre-mRNA processing. Predicted to serve as an alternative splicing branchpoint, this mutation causes TAPT1 exon 12 skipping, creating a protein-null allele. Additionally, our study reveals dysregulation of pathways involved in collagen and extracellular matrix biology in disease-relevant cells. Overall, our work highlights the power of transcriptomic approaches in deciphering the repercussion of non-coding variants as well as in illuminating the molecular mechanisms and underlying pathways of human diseases.
337 Compensation of Gravity-induced Errors on Hexapod-type Parallel Mechanism Machine Tools (2003)

This paper proposes a motion error compensation methodology for a Hexapod-type parallel mechanism machine tool. First, the contouring error attributable to the elastic deformation of struts caused by the gravity is predicted for an arbitrary position and orientation of spindle head. By compensating the predicted error on a reference trajectory, the machine's motion accuracy can be improved. It is experimentally verified that predicted and measured motion trajectories coincide well, even when the spindle is tilted by more than 23 degrees, where the gravity significantly deteriorates the machine's motion accuracy. By applying the proposed compensation method, the motion accuracy is significantly improved particularly near an edge of the machine's workspace.
Sinkhole detection with 3D full seismic waveform tomography (2020)

Sinkhole collapse may result in significant property damage and even loss of life. Early detection of sinkhole attributes (buried voids, raveling zones) is critical to limit the cost of remediation. One of the most promising ways to obtain subsurface imaging is 3D seismic full-waveform inversion. For demonstration, a recently developed 3D Gauss-Newton full-waveform inversion (3D GN-FWI) method is used to detect buried voids, raveling soils, and characterize variable subsurface soil/rock layering. It is based on a finite-difference solution of 3D elastic wave equations and Gauss-Newton optimization. The method is tested first on a data set constructed from the numerical simulation of a challenging synthetic model and subsequently on field data collected from two separate test sites in Florida. For the field tests, receivers and sources are placed in uniform 2D surface grids to acquire the seismic wavefields, which then are inverted to extract the 3D subsurface velocity structures. The inverted synthetic results suggest that the approach is viable for detecting voids and characterizing layering. The field seismic results reveal that the 3D waveform analysis identified a known manmade void (plastic culvert), unknown natural voids, raveling, as well as laterally variable soil/rock layering including rock pinnacles. The results are confirmed later by standard penetration tests, including depth to bedrock, two buried voids, and a raveling soil zone. Our study provides insight into the application of the 3D seismic FWI technique as a powerful tool in detecting shallow voids and other localized subsurface features.
Tiltless and centration adjustable scleral-sutured posterior chamber intraocular lens (2014)

Dr. Snyder is a consultant to Alcon Laboratories, Inc., Microsurgical Technology, Haag-Streit AG, and Humanoptics AG. Dr. Perez has no financial or proprietary interest in any material or method mentioned
Supplementary Figure 5 from 3D Growth of Cancer Cells Elicits Sensitivity to Kinase Inhibitors but Not Lipid Metabolism Modifiers (2023)

&lt;p&gt;Clustered heat map analysis of lipids in MDA-MB-468 and PC3 spheroids treated for 4 days with A. FASN and B. DGAT inhibitor at different concentrations. All Lipids were compared against DMSO control. Side covariates indicate lipid families, and lipids within each family are sorted by name.&lt;/p&gt;
International rotations (2016)

The majority of PDs for ACS, trauma, and SCC programs perceive a need for increased quality and quantity of operative cases. The majority recognize international fellow rotations as a valuable tool to supplement fellows' education.
Det passar inte alla : Arbetstillfredställelse, produktivitet och stress i kontorslandskap (2016)

Kontorslandskapen på Stora kontoret i Boliden har renoverats. Efter renoveringen ville företaget ha en utvärdering av vad personalen tyckte om den fysiska arbetsmiljön. Företaget ville även få fram förbättringsförslag för brister kopplat till den fysiska arbetsmiljön. Syftet med den här studien var att identifiera positiva och negativa aspekter för de fysiska arbetsmiljöfaktorerna, samt att identifiera eventuella samband mellan de faktorer som personalen var mest missnöjd över och arbetstillfredsställelse, produktivitet och stress. Ett andra syfte var att ta fram några åtgärdsförslag. En del i frågeställningen var om det fanns könsskillnader i hur personalen skattade de fysiska arbetsmiljöfaktorerna. Studien genomfördes med enkät samt systemgruppsseminarium som metod. Personalen var generellt nöjd med ventilation, möblernas funktion och kontorets estetiska utformning. Audiell avskildhet var den faktor som personalen var mest missnöjd med. Även missnöjdhet över bländning, utblicksmöjlighet och temperatur uppmärksammades i resultatet. Den här studien fann inga signifikanta könsskillnader för hur personalen skattat de fysiska arbetsmiljöfaktorerna. Tidigare studier har visat att det finns samband mellan fysiska arbetsmiljöfaktorer och arbetstillfredsställelse samt produktivitet, men inte ett entydigt resultat för stress. Den här studien stärkte sambandet för hur nöjd personalen var med audiell avskildhet och dess samverkan med arbetstillfredsställelse och produktivitet, men inte med stress. De förbättringsförslag som togs fram av systemgruppsseminariet var att införa riktlinjer för hur personalen skulle kunna minska störningen från ljud i kontorslandskapen, samt att avskilja avdelningarna mer. Rekommendation till Boliden blir att de bör förbättra den audiella avskildheten genom en kombination av åtgärder. De kan omplacera personal i kontorslandskapet baserat på arbetsuppgifter och känslighet för störning, förbättra avskiljningen mellan arbetsgrupper samt införa riktlinjer för hur personalen åstadkommer en god ljudmiljö.
Fatal Human Meningoencephalitis due to Halicephalobus Nematodes, Germany (2015)

Infections with Halicephalobus nematodes, causative agents of severe meningoencephalitis in horses, have rarely been reported in humans. In this study, the clinical, serological, cytokine, and histopathological findings of a rapidly progressive and eventually fatal meningoencephalitis in a previously healthy human are described. The helminth was finally diagnosed by specific polymerase chain reactions from post mortem tissue.
ChemInform Abstract: Bicyclopropylidene: A Unique Tetrasubstituted Alkene and Versatile C<sub>6</sub> Building Block for Organic Synthesis (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
CD56 Is a Sensitive and Diagnostically Useful Immunohistochemical Marker of Ovarian Sex Cord-Stromal Tumors (2007)

Ovarian sex cord-stromal tumors comprise a heterogeneous group of neoplasms with wide morphological diversity, and they can be mistaken for a variety of other tumors. Some types, including granulosa and Sertoli cell tumor, may be confused with a neuroendocrine neoplasm. CD56 is a widely used neuroendocrine marker with a high sensitivity for neuroendocrine tumors and is commonly used as part of a panel to distinguish between a neuroendocrine neoplasm and other tumors in the differential diagnosis. In this study, we investigate CD56 staining in ovarian sex cord-stromal tumors. CD56 staining has not previously been studied in this group of neoplasms. We stained a large series of ovarian sex cord-stromal neoplasms (n = 85) with CD56. Neoplasms studied were adult granulosa cell tumor (n = 40), juvenile granulosa cell tumor (n = 8), Sertoli cell tumor (n = 1), Sertoli-Leydig cell tumor (n = 14), Leydig cell tumor (n = 2), steroid cell tumor, not otherwise specified (n = 2), sclerosing stromal tumor (n = 1), sex cord tumor with annular tubules (n = 2), and fibroma (n = 15). Three uterine tumors resembling ovarian sex cord tumor were also studied. Nonneoplastic ovaries, including 3 cases of pregnancy-related granulosa or Sertoli cell proliferation, were also included. In nontumorous ovaries, granulosa cells of follicular and corpus luteum cysts were consistently negative. The normal ovarian stroma was diffusely positive, as were the 3 pregnancy-related proliferations. All sex cord-stromal tumors except one were positive with CD56; staining ranged from focal to diffuse but was usually diffuse involving more than 50% of tumor cells. Staining was usually membranous with weaker cytoplasmic positivity. CD56 immunoreactivity is almost universal in ovarian sex cord-stromal tumors of all the major morphological types and is of no value in distinguishing a sex cord-stromal and a neuroendocrine neoplasm. Since CD56 is an extremely sensitive marker of ovarian sex cord-stromal tumors, it may be useful in the diagnosis of this group of neoplasms, especially in cases which are alpha inhibin or calretinin negative, and in distinguishing these from mimics which are CD56 negative.
Electrode Characteristics of Individual, MnO<sub>2</sub> Coated Carbon Nanotubes (2012)

We investigate interfacial charge transfer between a manganese oxide (MnO 2 ) pseudocapacitor material and graphitic carbon supports in the limit where the graphitic carbon is defect free. We achieve this limit experimentally by fabricating model electrodes comprising MnO 2 deposited on single, pristine, isolated single-walled carbon nanotubes. Li ion cyclic voltammetry of the composites gives a specific capacitance in accord with MnO 2 storage capacities, but with kinetics limited by the poor electron transfer properties of defect free carbon. By fitting the data to an equivalent circuit model, we determine the charge transfer resistivity of MnO 2 -carbon interfaces to be 9 x 107 Ohm-cm when defects are absent, a limiting value for high power cathodes.
How to Handle Excessively Anonymized Datasets (2018)

Many companies and organizations have been collecting personal data with the aim of sharing it with partners. To prevent re-identification, the data should be anonymized before being shared. Although many anonymization methods have been proposed thus far, choosing one from them is not trivial since there is no widely accepted criteria. To overcome this situation, we have been conducting a data anonymization and re-identification competition, called PWS CUP, in Japan. In this paper, we introduce a problem appeared at the competition, named an excessive anonymization, and show how to formally handle it.
Performance analysis of bandlimited DS-CDMA systems in Nakagami fading (2004)

Accurate performance analysis of asynchronous bandlimited binary DS-CDMA systems in Nakagami-m fading is considered. The fading is assumed to be flat and slow. The spectrum raised-cosine and Beaulieu-Tan-Damen pulse shapes are employed. A new accurate approximation for computing the bit error rate of bandlimited DS-CDMA systems employing random spreading sequences is proposed. A substantial computational complexity reduction is achieved. The well-known standard Gaussian approximation, Holtzman's simplified improved Gaussian approximation, and the improved Holtzman's Gaussian approximation are also considered. The accuracies of the approximations are assessed using Monte-Carlo simulation. For a system employing a deterministic sequence for the desired user and random sequences for the active interfering users, a characteristic function method is employed to derive exact BER results. The new Beaulieu-Tan-Damen pulse outperforms the spectrum raised-cosine pulse in all situations examined.
Microwave‐Assisted Solution‐Phase Synthesis of 1,4,5‐Trisubstituted Pyrazoles. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Restoration of Microtubule Interaction and Cytotoxicity in D-<i>seco</i> Taxanes upon Incorporation of 20-Hydroxymethyl-4-allyloxy Groups (2015)

To probe the exact role of the oxetane D ring in both tubulin binding and cytotoxicity of taxanes, novel D-seco taxanes bearing a C4 ether substituent have been prepared from paclitaxel 1a. Among them, 20-hydroxymethyl-4-allyloxy D-seco taxane 5e is the most active in both tubulin and cytotoxicity assays. It is only slightly less potent than 1a on tubulin polymerization promotion in vitro and the most cytotoxic among all D-seco taxanes known to date. The reason for the loss and restoration of bioactivity for these D-seco taxanes is also discussed with the assistance of NMR and molecular modeling studies. From these results, we draw a conclusion that the intact D ring of taxanes is not strictly necessary for their binding to tubulin and cytotoxic effects.
Mapping data in peer-to-peer systems (2003)

We consider the problem of mapping data in peer-to-peer data-sharing systems. Such systems often rely on the use of mapping tables listing pairs of corresponding values to search for data residing in different peers. In this paper, we address semantic and algorithmic issues related to the use of mapping tables. We begin by arguing why mapping tables are appropriate for data mapping in a peer-to-peer environment. We discuss alternative semantics for these tables and we present a language that allows the user to specify mapping tables under different semantics. Then, we show that by treating mapping tables as constraints (called mapping constraints) on the exchange of information between peers it is possible to reason about them. We motivate why reasoning capabilities are needed to manage mapping tables and show the importance of inferring new mapping tables from existing ones. We study the complexity of this problem and we propose an efficient algorithm for its solution. Finally, we present an implementation along with experimental results that show that mapping tables may be managed efficiently in practice.