gebhart/patrepeval huggingface dataset:
Design and Formulation of Protein-Based NPDDS (2016)

INTRODUCTION Proteins are a versatile class of biopolymers whose functional properties are dictated by their amino acid composition. The biodegradation of proteins into simple amino acids makes them attractive polymers for drug delivery applications. As a result, protein polymers are being increasingly investigated for various nanoenabled drug delivery systems (1). In fact, the first protein-based nanoparticulate system is already in the market. Albumin-bound paclitaxel nanoparticles (Abraxanetm) was approved by the U.S. Food and Drug Administration (FDA) in 2005. In general, nanosystems used in drug delivery range in size from 100 to 1000 nm and are prepared using natural or synthetic polymers or lipids. The drug is encapsulated inside the nanosystem (nanocapsule or nanospheres) or is entrapped in the matrix of the nanosystem (nanoparticles). Alternatively, drugs or other agents of interest are adsorbed, complexed, or conjugated to the surface of the nanosystems. Proteins offer a number of advantages over synthetic polymers. Unlike synthetic polymers, which usually have a single type of functional groups, proteins have numerous functional groups (–NH2, –COOH, and –SH) for covalent and noncovalent modifications of the nanosystems. A distinct advantage over synthetic polymers is the proven biocompatibility of proteins. Furthermore, they are biodegradable and are broken down into nontoxic by-products. Protein polymers are derived from animals or plants and are, therefore, devoid of monomers or initiators that are found in synthetic polymers. However, the composition and purity of protein biopolymers are difficult to control. Similarly, it is important to protect the protein from premature proteolytic degradation in the body. Although most of the proteins are generally safe, nonautologus proteins can be immunogenic (2). Recombinant DNA (rDNA) technology or combination of synthetic and protein polymers is used to address these limitations of protein polymers (3,4).
Phosphine Oxide-Catalyzed γ-Umpolung Addition–Wittig Olefination (2018)

Key words dihydroquinolines - phosphine oxides - Wittig olefination - allenoates - umpolung - addition
Interaction of phase singularities on the spiral wave tail: reconsideration of capturing the excitable gap (2018)

The action mechanism of stimulation toward spiral waves (SWs) owing to the complex excitation patterns that occur just after point stimulation has not yet been experimentally clarified. This study sought to test our hypothesis that the effect of capturing excitable gap of SWs by stimulation can also be explained as the interaction of original phase singularity (PS) and PSs induced by the stimulation on the wave tail (WT) of the original SW. Phase variance analysis was used to quantitatively analyze the postshock PS trajectories. In a two-dimensional subepicardial layer of Langendorff-perfused rabbit hearts, optical mapping was used to record the excitation pattern during stimulation. After a SW was induced by S1-S2 shock, single biphasic point stimulation S3 was applied. In 70 of the S1-S2-S3 stimulation episodes applied on 6 hearts, the original PS was clearly observed just before the S3 point stimulation in 37 episodes. Pairwise PSs were newly induced by the S3 in 20 episodes. The original PS collided with the newly induced PSs in 16 episodes; otherwise, they did not interact with the original PS. SW shift occurred most efficiently when the S3 shock was applied at the relative refractory period, and PS shifted in the direction of the WT. In conclusion, quantitative tracking of PS clarified that stimulation in desirable conditions induces pairwise PSs on WT and that the collision of PSs causes SW shift along the WT. The results of this study indicate the importance of the interaction of shock-induced excitation with the WT for effective stimulation. NEW & NOTEWORTHY The quantitative analysis of spiral wave dynamics during stimulation clarified the action mechanism of capturing the excitable gap, i.e., the induction of pairwise phase singularities on the wave tail and spiral wave shift along the wave tail as a result of these interactions. The importance of the wave tail for effective stimulation was revealed.
LUCIE: a Laser Underwater Camera Image Enhancer (2002)

Calculation of the scattering and absorption coefficients obtained from the analysis of data taken in the waters off the coasts of Canada by NEARSCAT (a full spectrum narrow forward angle transmissometer-nephelometer) persuaded the authors that a laser assisted underwater camera system could provide better quality images over that of a conventional-system. Accordingly, the authors have designed and built a Laser Underwater Camera Image Enhancer (LUCIE). The system has been tested in a water tank facility and has been mounted on the HYSUB 5000, a remotely operated vehicle, for sea trials at a mean depth of 35 m in Patricia Bay near Victoria. In these waters the system has a range of 3 to 5 times that of a conventional camera with floodlights.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
An ultra-low-power SAR ADC with an area-efficient DAC architecture (2011)

An ultra-low-power area-efficient 8-bit successive approximation register (SAR) analog-to-digital converter (ADC) is presented. To achieve ultra-low-power performance a DAC architecture is proposed that employs two rail-to-rail low-power unity-gain buffers and only 4 minimum-size capacitors instead of the conventional binary-weighted capacitor array. Thereby, power consumption and area are drastically reduced by virtue of lower switching activity and smaller size capacitor array. The proposed 8-bit SAR ADC is designed and simulated in a 0.13μm CMOS process. Simulation results show that for a 2.4 kHz (12.4 kHz) input signal while sampling at 25 kHz, the ADC achieves an ENOB of 7.9 (7.8), consumes 290 nW (350 nW) form a 0.8 V analog supply and a 0.6 V digital supply, and achieves a FoM of 48 fj/conversion-step (62 fj/conversion-step).
New Trends in Software Methodologies, Tools and Techniques: Proceedings of the Eighth SoMeT_09, Volume 199 Frontiers in Artificial Intelligence and Applications (2009)

Software is an essential enabler for science and the new economy, but software often falls short of our expectations, remaining expensive and not yet sufficiently reliable for a constantly changing and evolving market. This publication, which forms part of the SoMeT series, consists of 41 papers, carefully reviewed and revised on the basis of technical soundness, relevance, originality, significance, and clarity. The papers explore new trends and theories which illuminate the direction of developments which may lead to a transformation of the role of software in tomorrows global information society. The book offers an opportunity for the software science community to think about where they are today and where they are going. The emphasis has been placed on human-centric software methodologies, end-user development techniques, and emotional reasoning, for an optimally harmonized performance between the design tool and the user. The handling of cognitive issues in software development and the tools and techniques related to this form part of the contribution to this book. Other comparable theories and practices in software science, including emerging technologies essential for a comprehensive overview of information systems and research projects, are also addressed. This work represents another milestone in mastering the new challenges of software and its promising technology and provides the reader with new insights, inspiration and concrete material to further the study of this new technology.IOS Press is an international science, technical and medical publisher of high-quality books for academics, scientists, and professionals in all fields. Some of the areas we publish in: -Biomedicine -Oncology -Artificial intelligence -Databases and information systems -Maritime engineering -Nanotechnology -Geoengineering -All aspects of physics -E-governance -E-commerce -The knowledge economy -Urban studies -Arms control -Understanding and responding to terrorism -Medical informatics -Computer Sciences
Thermal behavior of the ZrB<sub>2</sub> skeleton infiltrated with Cu and CuCrZr alloy (2022)

This paper presents the thermal behavior of ZrB 2 skeletal material (38% porosity) infiltrated with pure Cu or CuCrZr alloy. Gas-assisted pressure infiltration technology was used to prepare the composites. Thermal diffusivity, density and specific heat measurements were used to calculate the thermal conductivity—the room temperature values of the Cu-ZrB 2 and the CuCrZr-ZrB 2 material were 157 W m −1 K −1 and 146 W m −1 K −1 , respectively, and they decreased with increasing temperature. Analysis of the results showed significant influence of the interface on the thermal conductivity of the CuCrZr-ZrB 2 composite. The results indicate that the improved interfacial conductivity was formed due to the presence of the Zr in both the copper alloy and the ceramic skeleton. During infiltration, Zr atoms diffused from the liquid metal to the interface between the metal and the matrix. Here, they created a layer that had metal-related properties. The layer improved wettability of the interface and at the same time the thermal conductivity of the whole composite. The values were compared with the data of the Cu–graphite composite made by the powder metallurgical route where heat transfer through the interface approaches zero. Obtained experimental data were analyzed using the Differential Effective Media (DEM) technique, showing high thermal conductance of the interface between the CuCrZr metal matrix and ceramic skeleton.
Phase I Trial of Imexon in Patients With Advanced Malignancy (2007)

The phase II recommended dose of imexon is 875 mg/m2/d for 5 days every other week. A decrease in plasma thiols did correlate with imexon exposure.
Reducing write amplification in flash by death-time prediction of logical block addresses (2021)

Flash-based solid state drives lack support for in-place updates, and hence deploy a flash translation layer to absorb the writes. For this purpose, SSDs implement a log-structured storage system introducing garbage collection and write-amplification overheads. In this paper, we present a machine learning based approach for reducing write amplification in log structured file systems via death-time prediction of logical block addresses. We define death-time of a data element as the number of I/O writes before which the data element is overwritten. We leverage the sequential nature of I/O accesses to train lightweight, yet powerful, temporal convolutional network (TCN) based models to predict death-times of logical blocks in SSDs. We leverage the predicted death-times in designing ML-DT, a near-optimal data placement technique that minimizes write amplification (WA) in log structured storage systems. We compare our approach with three state-of-the-art data placement schemes and show that ML-DT achieves the lowest WA by utilizing the learnt I/O death-time patterns from real-world storage workloads. Our proposed approach results in up to 14% reduction in write amplification compared to the best baseline technique. Additionally, we present a mapping learning technique to test the applicability of our approach to new or unseen workloads and present a hyper-parameter sensitive study.
Human Stress-inducible Hsp70 Has a High Propensity to Form ATP-dependent Antiparallel Dimers That Are Differentially Regulated by Cochaperone Binding* (2018)

Eukaryotic protein homeostasis (proteostasis) is largely dependent on the action of highly conserved Hsp70 molecular chaperones. Recent evidence indicates that, apart from conserved molecular allostery, Hsp70 proteins have retained and adapted the ability to assemble as functionally relevant ATP-bound dimers throughout evolution. Here, we have compared the ATP-dependent dimerization of DnaK, human stress-inducible Hsp70, Hsc70 and BiP Hsp70 proteins, showing that their dimerization propensities differ, with stress-inducible Hsp70 being predominantly dimeric in the presence of ATP. Structural analyses using hydrogen/deuterium exchange mass spectrometry, native electrospray ionization mass spectrometry and small-angle X-ray scattering revealed that stress-inducible Hsp70 assembles in solution as an antiparallel dimer with the intermolecular interface closely resembling the ATP-bound dimer interfaces captured in DnaK and BiP crystal structures. ATP-dependent dimerization of stress-inducible Hsp70 is necessary for its efficient interaction with Hsp40, as shown by experiments with dimerization-deficient mutants. Moreover, dimerization of ATP-bound Hsp70 is required for its participation in high molecular weight protein complexes detected <i>ex vivo</i>, supporting its functional role <i>in vivo</i> As human cytosolic Hsp70 can interact with tetratricopeptide repeat (TPR) domain containing cochaperones, we tested the interaction of Hsp70 ATP-dependent dimers with Chip and Tomm34 cochaperones. Although Chip associates with intact Hsp70 dimers to form a larger complex, binding of Tomm34 disrupts the Hsp70 dimer and this event plays an important role in Hsp70 activity regulation. In summary, this study provides structural evidence of robust ATP-dependent antiparallel dimerization of human inducible Hsp70 protein and suggests a novel role of TPR domain cochaperones in multichaperone complexes involving Hsp70 ATP-bound dimers.
Recent advances in genomic and genetic studies in the Archaea (2013)

The accumulation of archaeal genomes has lagged significantly behind the Bacteria; however, in the last several years the coverage of the major phyla of Archaea has been significantly improved. There are now multiple genomes in several important genera such as Pyrobaculum, Sulfolobus, Thermococcus/Pyrococcus, Halobacterium, Methanosarcina, Methanopyrus and Methanocaldococcus. Comparative genomic studies are now under way, and in many cases there are several consortial multilaboratory groups, such as the SulfoSys community, which have started to break into new systems biology initiatives. At the same time, access to streamlined genetic approaches in the genera Sulfolobus, Thermococcus, Methanosarcina, and Halobacterium/Haloferax has improved significantly and is leveraging the genomic information in the Archaea. The result has been that genome-driven studies of metabolism, DNA replication and repair, transcription and translation, and posttranslational processing have become more detailed and that basic research findings are burgeoning. The areas of global gene regulation, the roles of small RNAs and mechanisms of transcription and DNA replication will be focus areas in the guidelines of this Research Topic. Recently, insights into the unique characteristics of archaeal transcription and the ability to study the effects of mutation in vivo following knock-in gene replacement have resulted in incisive findings.
The New Normal: Delayed Peak SARS-CoV-2 Viral Loads Relative to Symptom Onset and Implications for COVID-19 Testing Programs (2023)

In a highly immune adult population, median SARS-CoV-2 viral loads by cycle threshold and antigen measurements peaked on the fourth day of symptoms, with implications for testing practice. In contrast, viral loads for influenza A peaked soon after symptom onset.
Enzymes Lose Binding Affinity (Increased K <sub>m</sub> ) for Coenzymes and Substrates with Age: A Strategy for Remediation (2006)

This chapter contains sections titled: Introduction Remediation by High B Vitamin Intake of Variant Enzymes with Poor Binding Affinity (Km) for Coenzymes Deformation of Proteins in Mitochondria with Aging Nonmitochondrial Enzymes that are Deformed with Age Conclusion Acknowledgments References
Color Doppler ultrasound twinkling in pathological biomineralizations (2019)

The color Doppler ultrasound twinkling artifact has been observed on some kidney stones as well as various sites in the body where pathological biomineralization can occur. On kidney stones, twinkling was recently attributed to stabilized crevice microbubbles, which suggests that microbubbles may also be present on other minerals. However, it is unknown how crystal structure, composition, and the surrounding environment influences the presence and location of microbubbles and twinkling. Here, crystals found in pathological biomineralization (i.e., uric acid, cholesterol, calcium phosphate, and calcium oxalate), were grown in vitro, embedded in a tissue-mimicking phantom, and imaged with a research ultrasound system at 5 and 18.5 MHz. Doppler power was quantified and compared between crystal composition (n = 5 per type). We found twinkling was strongest in cholesterol crystals and weakest in calcium phosphate crystals. Micro-computed tomography (µCT) of an ex vivo calcium oxalate kidney stone (i.e., a heterogeneous crystal) submerged in water revealed the presence of gas within internal microcracks, which was confirmed by reducing the hydrostatic pressure in a subsequent µCT scan. Future work includes exposing pure in vitro crystals to µCT and ultrasound with changes in hydrostatic pressure to evaluate for internal gas pockets that may contribute to twinkling.
Need for Robust RF MEMS for Space Applications (2004)

INTRODUCTION Generally speaking, space has not been considered so far as a key player in new technologies. It is more a fast follower, the reason being the long and costly qualification programs which are directly linked to the combination of long life time (15 years for GEO satellites) and operation in harsh environment. Nevertheless the satellite industry could experience in the coming years, its biggest evolution since it joined the ranks of commerce. Thanks to increasing constraints on performance, cost and development cycles, it is possible that space industry could be at the cutting edge of the major technical evolution which is taking place in electronic industry. In some cases this evolution is going jointly with another low volume high added value industry : the military industry. In this paper, we will present and discuss Alcatel Space view in RF MEMS emerging technologies that may impact future telecom payload.
Photoproduct distribution spectrum of the sensitized photoreaction of 1,4-p-benzenonaphthalene (1986)

A correlation between the type of the photoproducts of 1,4,9,10,11,12-hexahydro-1,4-p-benzeno-naphthalene (1) and triplet carbonyl and non-carbonyl sensitizers has been investigated. Electron transfer from the alkene moiety of (1) to excited sensitizers may cause the formation of naphthalene. The cage compound (2) was formed via energy transfer from excited sensitizers (Et≥ 71 kcal/mol) to the triplet state (T1) of (1). The irradiation of benzaldehyde and (1) gave the cage compound (2) and (2RS, 2aRS, 3SR, 9RS)-2a,3,8,8a,9,10,11,12-octahydro-3,8-p-benzeno-2H-naphth[2,3-b]oxete (3).
The Inclusion of Gamification Solutions to Enhance User Enjoyment on Crowdsourcing Platforms (2018)

Games with a purpose offer the opportunity to motivate volunteers to participate in citizen science projects in a fun and engaging manner. In this regard, this paper introduces the gamification concepts present in our browser-based crowd-sourcing platform. The aim of these elements is to encourage users to voluntarily use their leisure time on regular basis to record and annotate data in a fun and playful environment. To ensure our platform appeals to a wide range of players, a variety of gamification elements aimed at different player groups are integrated including gamerscore, leaderboards, badges and bonus items to name but a few examples. To evaluate the effectiveness of these inclusions we conducted user surveys of 33 new players. This analysis indicates that the gamification additions increase user engagement and gratification when performing elementary crowdsourcing tasks.
Numerical Simulation of Compacting Process of Green Sand Molding Based on Sand Filling (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.
Facelift Patients Receiving Intraoperative Administration of a Self-assembling Hemostat Agent Experienced Minimal Bruising and No Acute Hematomas: A Pilot Study (2022)

Abstract Background Hematomas are consistently cited as the most common complication of facelift surgery, with reported incidence rates ranging from 1% to 9% despite preventative measures. A self-assembling RADA16 peptide solution (PuraSinus, 3-D Matrix, Newton, MA) designed to aid in wound healing, adhesion prevention, and bleeding control has demonstrated hemostatic control of intra- and postoperative bleeding associated with various surgical procedures, including nasal and sinus surgery. Objectives To report surgical experience using novel application of RADA16 hemostatic agent in facelift procedures. Methods Through exploring incorporation of RADA16 hemostatic agent into standard of care, 15 higher-risk facelift patients were treated intraoperatively between December 2020 and July 2021. Postoperative follow-up was on post-procedure day 1 and 3 and at approximately one week. During follow-up, potential complications were assessed subjectively, including hematoma, swelling, and bruising; postoperative observations recorded; and photographs taken. Results Among facelift patients receiving intraoperative RADA16 hemostatic agent there were no hematomas or protracted ecchymosis events. The only significant complication was one patient admitted for intravenous hydration due to post-operative nausea and vomiting. All patients had minimal bruising or a dramatic absence of bruising and experienced no hemorrhage or hematoma. Through surgical experience, technique for RADA16 hemostatic agent placement was optimized and procedural details are provided. Conclusions Intraoperative administration of topical RADA16 hemostatic agent appears to deter acute hematoma and hemorrhage formation and early experience suggests that RADA16 hemostatic agent may also attenuate post-operative bruising in facelift patients. These observations warrant further investigation in a larger randomized controlled study. Level of Evidence: 4
Desing of fully biodegradable impact resistant polylactide-based materials mediated with nanofillers : from toughness to supertoughness (2013)

International audience
Identification à l'aide de capteurs optiques à réseaux de Bragg des coefficients de dilatation hygroscopiques d'un composite à matrice organique (2012)

Cette étude porte sur l'identification des coefficients de dilatation hygroscopique de matériaux composites au moyen d'une nouvelle technique de mesure. Celle-ci repose sur l'insertion de capteurs optiques à réseaux de Bragg au coeur de la structure composite. Cette méthode est dédiée à la mesure de la déformation hygroscopique induite par la diffusion d'humidité dans un composite. L'évolution de la déformation, due à l'absorption d'humidité, a été représentée en fonction de la teneur en eau, afin de caractériser le coefficient de dilatation hygroscopique.