gebhart/patrepeval huggingface dataset:
ORTHOPAEDIC RESIDENT SELF-ASSESSMENT OF OPERATIVE EXPERIENCE IN PRIMARY HIP AND KNEE ARTHROPLASTY (2012)

Purpose Case logs have been utilized as a means of assessing residents surgical exposure and involvement in cases. It can be argued that the degree of involvement in operative cases is as important as absolute number of cases logged. A log which contains accurate information on actual participation in surgical cases in addition to self reported competency, is a powerful tool in obtaining a true reflection of surgical experience. Thus a prerequisite for a valuable log is the ability to perform an accurate self-assessment. Numerous studies have shown mixed results when examining residents ability to perform self-assessment on varying tasks. The purpose of the study was to examine the correlation between residents self-assessment and staff surgeons evaluation of surgical involvement and competence in performing primary hip and knee arthroplasty surgery.

Method Self assessment data from 65 primary hip and knee arthroplasty cases involving 17 residents and 17 staff surgeons (93% response rate) was analyzed. Interobserver agreement between residents self perception and staff surgeons assessment of involvement was evaluated using the Intraclass Correlation Coefficient (ICC). An assessment of competency was performed utilizing a categorical global scale and evaluated with the Kappa statistic (k). Furthermore, a structured surgical skills assessment form was piloted as an objective appraisal of resident involvement and comparisons were made to resident and staff perception.

Results The Intraclass Correlation Coefficient for resident involvement between Resident and Staff was 0.80 (0.69–0.88) which represents substantial agreement between the groups. The agreement between resident and staff with regard to residents competency to perform case was k = 0.67 (0.50–0.84). The ICC for Resident, Staff, and Third Party observer utilizing the piloted skills assessment form was 0.82 (0.75–0.88) which represents substantial agreement and helps to confirm the agreement between various members of the surgical team.

Conclusion This study may help to confirm the ability of orthopaedic residents to perform a self-assessment of their degree of involvement and performance competency in primary hip and knee arthroplasty surgery. Furthermore, the staff surgeons assessment of resident involvement was highly correlated with the surgical skills assessment form. The inclusion of a self-assessment is a valuable addition to the surgical case log.
Size of the urogenital hiatus in the levator ani muscles in normal women and women with pelvic organ prolapse*1 (1998)

Increasing pelvic organ prolapse is associated with increasing urogenital hiatus size; the hiatus is larger after several failed operations than after successful surgery or single failure.
Haploinsufficiency of ZNF251 causes DNA-PKcs-dependent resistance to PARP inhibitors in BRCA1-mutated cancer cells (2023)

Poly (ADP-ribose) polymerase (PARP) inhibitors represent a promising new class of agents that have demonstrated efficacy in treating various cancers, particularly those that carry <i>BRCA1/2</i> mutations. The cancer associated <i>BRCA1/2</i> mutations disrupt DNA double strand break (DSB) repair by homologous recombination (HR). PARP inhibitors (PARPis) have been applied to trigger synthetic lethality in <i>BRCA1/2</i>-mutated cancer cells by promoting the accumulation of toxic DSBs. Unfortunately, resistance to PARPis is common and can occur through multiple mechanisms, including the restoration of HR and/or the stabilization of replication forks. To gain a better understanding of the mechanisms underlying PARPi resistance, we conducted an unbiased CRISPR-pooled genome-wide library screen to identify new genes whose deficiency confers resistance to the PARPi olaparib. Our study revealed that ZNF251, a transcription factor, is a novel gene whose haploinsufficiency confers PARPi resistance in multiple breast and ovarian cancer lines harboring BRCA1 mutations. Mechanistically, we discovered that <i>ZNF251</i> haploinsufficiency leads to constitutive stimulation of DNA-PKcs-dependent non-homologous end joining (NHEJ) repair of DSBs and DNA-PKcs-mediated fork protection in <i>BRCA1</i>-mutated cancer cells (BRCA1mut + <i>ZNF251</i>KD). Moreover, we demonstrated that DNA-PKcs inhibitors can restore PARPi sensitivity in BRCA1mut + <i>ZNF251</i>KD cells <i>ex vivo</i> and <i>in vivo</i>. Our findings provide important insights into the mechanisms underlying PARPi resistance and highlight the unexpected role of DNA-PKcs in this phenomenon.
An Analysis of Stochastic Shortest Path Problems (1991)

We consider a stochastic version of the classical shortest path problem whereby for each node of a graph, we must choose a probability distribution over the set of successor nodes so as to reach a certain destination node with minimum expected cost. The costs of transition between successive nodes can be positive as well as negative. We prove natural generalizations of the standard results for the deterministic shortest path problem, and we extend the corresponding theory for undiscounted finite state Markovian decision problems by removing the usual restriction that costs are either all nonnegative or all nonpositive.
Native human adipose stromal cells: localization, morphology and phenotype (2011)

The use of complementary methodological approaches to study native human ASCs revealed their immunophenotype, their specific morphology, their location within AT and their stemness. Furthermore, our data strongly suggest that human ASCs participate in adipogenesis during AT development.
A versatile interface for avionics computers (2011)

♦ Flexible hardware ♦ Scalable ♦ Self-calibrating ♦ High Voltage Capability ♦ Reduced surface From Dedicated Interface to complete Versatile I/O Interface…
Combined anaerobic digestion and biological nitrogen removal for piggery wastewater treatment : a modelling approach (2008)

In order to deal with the environmental problems associated with animal production industrialization and at the same time considering energy costs increasing, a piggery wastewater treatment process consisting of combined anaerobic digestion and biological nitrogen removal by activated sludge was developed. This contribution presents a modelling framework in order to optimize this process. Modified versions of the well established ASM1 and ADM1 models have been used. The ADM1 was extended with biological denitrification. pH calculation and liquid gastransfer were modified to take into account the effect of associated components. Finally, two interfaces (ADMtoASM and ASMtoADM) were built in order to combine both models. These interfaces set up the COD, nitrogen, alkalinity and charge fractionation between both models. However, for the mass balances between both models, some hypotheses were considered and might be evaluated.
A Remarkably Simple Conversion of Nitriles to Thioamides (1994)

Abstract Thiolacetic acid and light smoothly convert nitriles to thioamides.
A Bayesian Method for Predicting Future Customer Need Distributions (2011)

This article presents a Bayesian method to predict future customer need distributions based on forecasts of external factors and forecast accuracies. It is critically important to accurately predict future customer needs when strategically deciding what product to develop. However, prediction is challenging because customer preference changes as external factors that influence customer preference change over time. Consequently, customer needs at the time of product design decisions and at the time of new product market introductions may be significantly different. While external factors can be forecasted, forecasts are not necessarily accurate. This paper outlines a Bayesian approach to incorporate accuracies of forecasts in predicting future customer need distributions. An illustrative example demonstrates impacts of forecast accuracies on customer need distributions and on a strategic design decision. In this example, the customer need is ‘fuel-efficient vehicle’, the external factor is the gasoline price index (defined as gasoline price divided by consumer price index), and the strategic design decision is the selection of the next vehicle from gasoline-powered, hybrid, and electric. Sensitivity analysis is performed in order to study how a strategic design decision changes with forecasts and forecast accuracies.
GreenBearings – Friction Behaviour of DLC-Coated Dry Running Deep Groove Ball Bearings (2015)

Due to the use of rolling bearings instead of plain bearings friction and wear are drastically reduced in all kind of machines. However, despite the high technical standard of modern rolling bearings there is still a significant potential for optimization. Preliminary Studies show a reduction of the friction torque of up to 44 % compared to conventional rolling bearings because of the use of tribological coatings in certain applications. Based on the millionfold usage of rolling bearings in all industrial fields the reduced lost energy adds up to a remarkable potential for energy savings. If friction and wear are lowered sufficiently, the use of conventional lubricants based on mineral oil can be successively decreased or even completely avoided. In the latter case, the socalled dry running of the rolling bearing, the energy consumption of machines and systems can additionally be reduced significantly. For example, pumping stations or compressed air units, which would be necessary for transporting or spraying the lubricants, can then be saved.This paper presents first results of DLC-coated deep groove ball bearings, which are tested in a four-bearing-test-rig under purely radial load with respect to their friction and wear behaviour.
Motion-supervised Co-Part Segmentation (2021)

Recent co-part segmentation methods mostly operate in a supervised learning setting, which requires a large amount of annotated data for training. To overcome this limitation, we propose a self-supervised deep learning method for co-part segmentation. Differently from previous works, our approach develops the idea that motion information inferred from videos can be leveraged to discover meaningful object parts. To this end, our method relies on pairs of frames sampled from the same video. The network learns to predict part segments together with a representation of the motion between two frames, which permits reconstruction of the target image. Through extensive experimental evaluation on publicly available video sequences we demonstrate that our approach can produce improved segmentation maps with respect to previous self-supervised co-part segmentation approaches.
Signaling events connecting mycotoxin biosynthesis and sporulation in Aspergillus and Fusarium spp. (2003)

Secondary metabolite production and sporulation are tightly co-regulated in the Aspergilli and Fusaria. Here we discuss two conserved pathways, including a G-protein/cAMP/Protein kinase A cascade and an oxylipin-mediated signalling process, that genetically link sporulation and secondary metabolism in these genera. The G-protein alpha subunit FadA negatively regulates aflatoxin and cyclopiazonic acid production in Aspergillus, and positively regulates penicillin production in A. nidulans and tricothecene production in Fusarium sporotrichiodes. Inactivation of FadA eliminates or decreases asexual spore production in both genera. The G-protein cascade is conserved throughout eukaryotes, and regulation of sporulation and secondary metabolism by this signal transduction pathway appears to be conserved within filamentous fungi. On the other hand, the oxylipin-mediated signalling pathway appears to be restricted to filamentous fungi. We have identified novel genes encoding putative dioxygenases likely to be responsible for secreted oxylipins which act as sporulation factors. Deletion of these genes affects asexual sporulation and secondary metabolite production in A. nidulans and F. sporotrichiodes.
Analysis of Older Users’ Perceived Requests and Opportunities with Technologies (2011)

The HERMES Cognitive Care and Guidance for Active Aging project proposes an integrated approach to cognitive assistance, promoting the autonomy of elderly users through pervasive technology. This work aims to describe elderly people’s opinions when they are presented scenarios developed in this project. Two focus groups were organized in Austria and Spain with a view to collecting their impressions about the way in which the technological device can cover their needs; complementarily, a second session was conducted including a quantitative questionnaire. Although some participants were reluctant to use the technology, they welcomed some functionalities of the HERMES system and they considered that using them can help them to become familiar with them. Usefulness, usability, and use of real-life information for functionalities such as cognitive games are considered to be key areas of the project. This evaluation has provided the developers of the system with meaningful information to improve it and it guarantees that the system addresses elderly people’s needs.
Quantitative Analysis of Diffusion Weighted Imaging May Improve Risk Stratification of Prostatic Transition Zone Lesions (2022)

Quantitative analysis of diffusion weighted images may help avoid unnecessary biopsies of transition zone PI-RADS 3 lesions.
Synthesis and Characterization of Thrombin Conjugated γ‐Fe<sub>2</sub>O<sub>3</sub> Magnetic Nanoparticles for Hemostasis (2009)

Abstract Thrombin is the final protease produced in the clotting pathways. Thrombin has been used in the clinic more than six decades for topical hemostasis and wound management. In human plasma the half‐life of thrombin is shorter than 15 seconds due to close control by inhibitors. In order to stabilize thrombin, this enzyme was conjugated covalently and physically to γ‐Fe 2 O 3 magnetic nanoparticles. The physical conjugation was accomplished through adsorption of thrombin to BSA coating on the nanoparticles. The coagulant activity of the covalently bound thrombin was significantly lower than that of the physically adsorbed thrombin. Leakage of the physically bound thrombin into PBS containing 4% HSA was negligible. The physical conjugation of thrombin onto the nanoparticles stabilized the thrombin against its major inhibitor antithrombin III and improved its storage stability. At optimal CaCl 2 concentration, the clotting time by the bound thrombin is shorter than that of the free enzyme. This novel conjugated thrombin may be an efficient candidate for topical hemostasis and wound healing.
Two-stage sinusoidal generator with calibration and pulse train amplitude feedback for ultrasonic applications (2017)

Ultrasonic applications require precise knowledge of the dispatched wave in order to process the returning signal. In this work, a cost effective two stage resonant sinusoidal source is presented, capable to adjust on demand both frequency and amplitude of the sinusoidal output. The source tunes automatically to the load parameters using pre-calibration, and is able to drive a range of different piezoelectric sensors. A unique feature is an additional feedback loop that adjusts the amplitude during pulsing and compensates for temperature related parameter drift of the load over long pulsing periods. Design considerations and control implementation are discussed. Experimental validation is carried out on a 20 W laboratory prototype.
Repeated Intrastromal Injections of Voriconazole in Combination with Corneal Debridement for Recalcitrant Fungal Keratitis – a Case Series (2016)

Repeated intrastromal injection of voriconazole in combination with corneal debridement appears to be an effective and safe way to treat recalcitrant fungal keratitis, even in Fusarium keratitis.
18.2: <i>Invited Paper:</i> Semipolar Micro‐LED for Full‐color Display and Visible Light Communication (2021)

Micro‐LEDs (μ‐LEDs) are well known to have a thriving future in the next‐generation display field. However, conventional μ‐LEDs grown on c‐plane GaN have a severe wavelength shift due to the quantum confined Stark effect (QCSE), which seriously affects the color quality of μ‐LEDs display. In order to fundamentally solve this problem, we grown blue μ‐LED with a 30 µm diameter on the (20–21) semipolar GaN combined with perovskite quantum dots (PQDs) color conversion layer, to achieve high‐quality full‐color μ‐LED, realizing a wide color gamut with 99.2% National Television Standards Committee (NTSC) space and 93.0% Rec 2020 in the CIE 1931, and the peak wavelength hardly shifts, indicating an excellent inhibitory on QCSE. Meanwhile, the semipolar blue μ‐LED excitation light can achieve a wide 3‐dB bandwidth of 652 MHz due to the faster carrier recombination rate, making semipolar LEDs more attractive in the high‐speed visible light communication (VLC).
Muscle hypertrophy in hypoxia with inflammation is controlled by bromodomain and extra-terminal domain proteins (2017)

Some of the Chronic Obstructive Pulmonary Disease (COPD) patients engaged in exercise-based muscle rehabilitation programs are unresponsive. To unravel the respective role of chronic hypoxia and pulmonary inflammation on soleus muscle hypertrophic capacities, we challenged male Wistar rats to repeated lipopolysaccharide instillations, associated or not with a chronic hypoxia exposure. Muscle hypertrophy was initiated by bilateral ablation of soleus agonists 1 week before sacrifice. To understand the role played by the histone acetylation, we also treated our animals with an inhibitor of bromodomains and extra terminal proteins (I-BET) during the week after surgery. Pulmonary inflammation totally inhibited this hypertrophy response under both normoxic and hypoxic conditions (26% lower than control surgery, p < 0.05), consistent with the S6K1 and myogenin measurements. Changes in histone acetylation and class IIa histone deacetylases expression, following pulmonary inflammation, suggested a putative role for histone acetylation signaling in the altered hypertrophy response. The I-BET drug restored the hypertrophy response suggesting that the non-response of muscle to a hypertrophic stimulus could be modulated by epigenetic mechanisms, including histone-acetylation dependant pathways. Drugs targeting such epigenetic mechanisms may open therapeutic perspectives for COPD patients with systemic inflammation who are unresponsive to rehabilitation.
Distributed Load Balancing in Heterogeneous Peer-to-Peer Networks for Web Computing Libraries (2006)

In this work we present a novel architecture for distributed computing in a peer-to-peer network. In particular, we realize the Paderborn University BSP-based Web Computing Library (PUBWCL), which was formerly used as a centralized client-server architecture for scheduling and load balancing, as a pure peer-to-peer system. By using distributed heterogeneous hash tables (DHHT), our architecture features scheduling and load balancing of tightly coupled, massively parallel algorithms in the bulk-synchronous (BSP) style with a minimal number of migrations. Furthermore, our architecture is capable of heterogeneous BSP programs whereas the former version of PUBWCL could only handle homogeneous BSP programs
ChemInform Abstract: An Efficient Synthesis of Stereodefined Enynes and Dienes via Pd‐ Catalyzed Reaction of Chloroenynes and Chlorodienes with Grignard Reagents. (1997)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Processing of Fine-Scale Piezoelectric Ceramic/Polymer Composites for Sensors and Actuators (1996)

The objective of the research effort at Rutgers is the development of lead zirconate titanate (PZT) ceramic/polymer composites with different designs for transducer applications including hydrophones, biomedical imaging, non-destructive testing, and air imaging. In this review, methods for processing both large area and multifunctional ceramic/polymer composites for acoustic transducers were discussed.
Effects of Dietary Arachidonic Acid Supplementation on Age-Related Changes in Endothelium-Dependent Vascular Responses (2007)

The purpose of the present study was to examine the effects of dietary supplementation of arachidonic acid (ARA) on age-related changes in endothelium-dependent vascular responses. Young male Fisher-344 rats (2-mo-old) and aged rats of the same strain (22-mo-old) were randomly separated into a control diet group (young control, YC; old control, OC) and an ARA-containing diet group (young ARA, YA; old ARA, OA). After a 2-mo feeding period, vascular responses were evaluated using both endothelium-intact and -denuded aortic rings. Phenylephrine (alpha1-adrenoceptor agonist)-induced vasoconstrictor responses in endothelium-intact rings from group OC tended to be augmented compared with those of rings from groups YC and YA, although this augmentation was significantly suppressed by dietary supplementation of ARA. There were no significant differences in vascular responses to phenylephrine in endothelium-denuded rings among groups YC, YA, OC, and OA. Acetylcholine (Ach)-induced, endothelium-dependent vasorelaxation was attenuated in groups OC and OA compared with that in groups YC and YA. ARA supplementation induced slight enhancement of Ach-induced vasorelaxation in aged rats. Ach-induced vasorelaxation correlated very well with aortic ARA concentration in aged rats, but not in young rats. There were no significant differences in endothelium-independent vasodilator responses to sodium nitroprusside in endothelium-denuded rings among groups YC, YA, OC, and OA. These findings suggest that dietary ARA supplementation improves the age-related endothelial dysfunction that leads to various cardiovascular diseases.
Hydroxyl radical induced decarboxylation of amino acids. Decarboxylation vs bond formation in radical intermediates (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTHydroxyl radical induced decarboxylation of amino acids. Decarboxylation vs bond formation in radical intermediatesL. Kraig Steffen, Richard S. Glass, Mahmood Sabahi, George S. Wilson, Christian Schoeneich, Sabine Mahling, and Klaus Dieter AsmusCite this: J. Am. Chem. Soc. 1991, 113, 6, 2141–2145Publication Date (Print):March 1, 1991Publication History Published online1 May 2002Published inissue 1 March 1991https://pubs.acs.org/doi/10.1021/ja00006a035https://doi.org/10.1021/ja00006a035research-articleACS PublicationsRequest reuse permissionsArticle Views611Altmetric-Citations69LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts