gebhart/patrepeval huggingface dataset:
Feedback steganalysis decision making system (2007)

In this article, we present a new sensitive data detection feedback system. The basic components of this system are: a) localization of hidden data techniques and b) common and the new decision making techniques. The decision making statistical tests include: chi-square, parametric chi, Kolmogorov-Smirnov and F-test. Computer simulations will show that the proposed method provides a good localization for both randomly and sequentially embedded sensitive data. Finally, the presented system may work for both: compressed and non-compressed cases. Comparison with common existing steganalysis methods will also be presented.
Streamlining cardiovascular clinical trials to improve efficiency and generalisability (2017)

Controlled trials provide the most valid determination of the efficacy and safety of an intervention, but large cardiovascular clinical trials have become extremely costly and complex, making it difficult to study many important clinical questions. A critical question, and the main objective of this review, is how trials might be simplified while maintaining randomisation to preserve scientific integrity and unbiased efficacy assessments. Experience with alternative approaches is accumulating, specifically with registry-based randomised controlled trials that make use of data already collected. This approach addresses bias concerns while still capitalising on the benefits and efficiencies of a registry. Several completed or ongoing trials illustrate the feasibility of using registry-based controlled trials to answer important questions relevant to daily clinical practice. Randomised trials within healthcare organisation databases may also represent streamlined solutions for some types of investigations, although data quality (endpoint assessment) is likely to be a greater concern in those settings. These approaches are not without challenges, and issues pertaining to informed consent, blinding, data quality and regulatory standards remain to be fully explored. Collaboration among stakeholders is necessary to achieve standards for data management and analysis, to validate large data sources for use in randomised trials, and to re-evaluate ethical standards to encourage research while also ensuring that patients are protected. The rapidly evolving efforts to streamline cardiovascular clinical trials have the potential to lead to major advances in promoting better care and outcomes for patients with cardiovascular disease.
Development of Sharp Flanging Technology for Aluminum Panels (2005)

Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Sergey F. Golovashchenko, Nicholas M. Bessonov; Development of Sharp Flanging Technology for Aluminum Panels. AIP Conf. Proc. 5 August 2005; 778 (1): 687–690. https://doi.org/10.1063/1.2011302 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
Prospected randomized study of two Y devices in continuous ambulatory peritoneal dialysis (CAPD). (1989)

To evaluate acceptability, safety, and efficacy of a Y set with two short branches (TAS) filled with electrolytic chloroxidizer solution during the dwell time, 60 patients were randomly allocated to be treated with the traditional Y set (TCS) or with the TAS. Twenty-three were new patients whereas the remaining 37 were patients already on continuous ambulatory peritoneal dialysis (CAPD) with the TCS. The follow-up was 416.5 months in the control group and 387.4 months in the test group. During the study period there were 6 peritonitis episodes in each group with an incidence of 1 episode every 69.4 patient-months in the control group and 1 episode every 64.6 patient-months in the test group. Twenty-four patients (80%) in the control group and 27 (90%) in the test group were free from peritonitis. The probability to remain free from peritonitis was respectively 87% and 83% in the test group and in control group after 12 months, 70% and 78% after 21 months. Seventy-nine percent of the patients who used both systems preferred the TAS for better handling, lower encumbrance, and major safety. One patient preferred the TCS, three patients did not find any differences between the two devices.
Neutron spectroscopy with N<sub>2</sub>-filled high-pressure large-volume spherical proportional counters (2022)

Precise in-situ measurements of the neutron flux in underground laboratories is crucial for direct dark matter searches, as neutron induced backgrounds can mimic the typical dark matter signal. The development of a novel neutron spectroscopy technique using Spherical Proportional Counters is investigated. The detector is operated with nitrogen and is sensitive to both fast and thermal neutrons through the 14 N(n, α ) 11 B and 14 N(n, p) 14 C reactions. This method holds potential to be a safe, inexpensive, effective, and reliable alternative to 3 He-based detectors. Measurements of fast and thermal neutrons from an Am-Be source with a Spherical Proportional Counter operated at pressures up to 2 bar at Birmingham are discussed.
Epidermal growth factor (EGF) and EGF receptor in hypospadias (1997)

The mean EGF value was deficient in skin adjacent to hypospadias defects compared to normal phallic skin, suggesting that the inadequate expression of EGF may be related to the aetiology of hypospadias and to possible wound complications following surgery for hypospadias.
Syntheses of a Triad of Flt3 Kinase Inhibitors: From Bench to Pilot Plant (2008)

We have designed and developed an alternative synthesis for the manufacturing of a triad of Flt3 kinase inhibitors (AST487, ATH686, and AUZ454) to support clinical assessments of patients with Flt3-dependent tumor diseases. The new synthesis is convergent, environmentally friendly, practical, and safe and requires no chromatographic purification.
Data from Combination IFNβ and Membrane-Stable CD40L Maximize Tumor Dendritic Cell Activation and Lymph Node Trafficking to Elicit Systemic T-cell Immunity (2023)

&lt;div&gt;Abstract&lt;p&gt;Oncolytic virus therapies induce the direct killing of tumor cells and activation of conventional dendritic cells (cDC); however, cDC activation has not been optimized with current therapies. We evaluated the adenoviral delivery of engineered membrane-stable CD40L (MEM40) and IFNβ to locally activate cDCs in mouse tumor models. Combined tumor MEM40 and IFNβ expression induced the highest cDC activation coupled with increased lymph node migration, increased systemic antitumor CD8&lt;sup&gt;+&lt;/sup&gt; T-cell responses, and regression of established tumors in a cDC1-dependent manner. MEM40 + IFNβ combined with checkpoint inhibitors led to effective control of distant tumors and lung metastases. An oncolytic adenovirus (MEM-288) expressing MEM40 + IFNβ in phase I clinical testing induced cancer cell loss concomitant with enhanced T-cell infiltration and increased systemic presence of tumor T-cell clonotypes in non–small cell lung cancer (NSCLC) patients. This approach to simultaneously target two major DC-activating pathways has the potential to significantly affect the solid tumor immunotherapy landscape.&lt;/p&gt;&lt;/div&gt;
Optimizing SIP application layer mobility over IPv6 using layer 2 triggers (2005)

The paper describes a solution for the optimization of session initiation protocol (SIP) based mobility over IPv6 in an 802.11b network as well as its theoretical evaluation and actual performance. The time necessary for a complete handoff depends on multiple factors. We focus on the delay accumulated during movement detection and try to bring it to a minimum using upward propagation of events generated by a Layer 2 entity. This allows us to speed up handoffs and get closer to a mobility solution applicable in "real-world" communications. We are using SIP both as a communications signalling protocol and as a means of handling application layer terminal mobility.
Clearance of Particles and Lipophilic Solutes from Central Airways (1994)

Mucociliary clearance affects not only inhaled particles, but most likely dissolved lipophilic solutes. A mathematical model predicts that the lipids in the mucous lining layer retard the penetration of highly lipophilic carcinogens, such as polycyclic aromatic hydrocarbons, to the airway epithelium. The penetration should be slow enough to allow a substantial mucociliary clearance of such substances. Methods have been developed to study the mucociliary clearance of lipophilic solutes deposited in known, localized airway regions. Validation of the model provides important information on the clearance of inhaled lipophilic carcinogens in the conducting airways and on the likely exposure of airway epithelial cells to such materials.
Order–disorder character of PbTiO<sub>3</sub> (2007)

We report the displacive and order-disorder characters of PbTiO3 analyzed using a classical atomic model which was developed under the inverse relation between the bond length and the bond valence. The ferroelectric phase changes to the paraelectric phase around 700 K, and the histograms of Ti-O and Pb-O bond lengths have three peaks which become a single peak above the phase transition temperature. The order-disorder character of this material was clearly shown by analyzing the ion displacement magnitudes.
Conductive sol–gel films (2014)

We report that silver nanowires (AgNW) entrapped in a series of sol–gel thin films – zirconia, alumina, titania and silica – provide conductive, highly flexible, highly adhesive, transparent thin films with excellent thermal and electrical stability. These films were subjected to intensive study and characterization including resistance, percolation analysis, critical bending angle analysis, critical thermal stability, transparency, and more. Remarkably, when resistance is kept constant, all of the studied parameters follow the same order – either increasing or decreasing – of ZrO2, SiO2, Al2O3, and TiO2. A detailed interpretation, based on the particle-sizes of the elementary sol–gel building blocks, is provided. In particular we found that the AgNWs re-enforce the ceramic matrices, thus providing excellent electroconductive stability with low silver concentration and high degree of homogeneity of the dopant distribution. Having in mind that current materials for films with these properties are often accompanied by disadvantages (such as brittleness, scarcity and poor adhesion) we offer the new conductive films as an interesting alternative to be considered.
Microarray analysis of gene expression patterns during healing of rat corneas after excimer laser photorefractive keratectomy. (2002)

Microarray analysis of 1176 identified 588 genes with reproducible patterns of expression in rat corneas on days 3 and 7 after PRK and 73 genes with a threefold change in expression compared with untreated corneas. Hierarchical clustering of these 588 genes identified 10 clusters of genes with very similar patterns of expression. Clustering of genes with similar patterns of expression implies a common regulatory pathway for the genes within a cluster, and identifies potential new targets for regulating corneal wound healing.
Polarization-multiplexed 1 Gsymbol/s, 128 QAM (14 Gbit/s) coherent optical transmission over 160 km using a 1.4 GHz Nyquist filter (2008)

We have transmitted a polarization-multiplexed 1-Gsymbol/s, 128 QAM (14-Gbit/s) coherent optical signal over 160 km using a 1.4-GHz Nyquist filter. A heterodyne technique was used between a frequency-stabilized C <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> H <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> laser and high-speed local oscillator.
Synthesen mit einem chiralen Baustein aus dem Citratzyklus: (2<i>R</i>,3<i>S</i>)‐Isocitronensäure aus einer Fermentation mit Sonnenblumenöl (2008)

Viel hilft viel: Bisher war (2R,3S)-Isocitronensäure (1), ein Bestandteil des Citratzyklus, nicht in genügender Menge für präparative Synthesen herstellbar. Ein neuer Zugang zu dieser Säure im kg-Maßstab kombiniert eine biotechnologische Herstellung durch Fermentation von Sonnenblumenöl mit einem chemischen Trennverfahren. In einer Vielzahl von Umwandlungen in weitere chirale Bausteine konnte 1 als neues Mitglied des chiralen Pools eingeführt werden (siehe Schema). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2008/z705000_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
The Bactericidal Effect of Nd:YAG, Ho:YAG, and Er:YAG Laser Irradiation in the Root Canal: An <i>in Vitro</i> Comparison (1999)

Our findings indicate that all three lasers act as strongly effective microbicides without causing unfavorable temperature rises at the settings used. They can thus be considered a valuable tool for root canal treatment.
Uklanjanje arsena primenom prirodnog i solvotermalno sintetisanog kalcita modifikovanog oksidima metala (2014)

Predmet istraživanja ove doktorske teze bio je pronalazak novih materijala, optimalnih adsorpcionih svojstava, sa mogućnošću praktične primene za efikasno uklanjanje As(V)-jona iz vodenog rastvora. U okviru rada razmatran je uticaj sinteze i metoda modifikacije na svojstva krajnjeg proizvoda, tj. adsorbenta, u zavisnosti od njegovih adsorptivnih svojstava i primene. Postupak sinteze adsorpcionih materijala bio je dvostepen. U prvom stupnju sinteze izvršena je priprema visokoporoznih osnova, tj. solvotermalno sintetisanog kalcita i kalcinisane ljuske kokošjeg jajeta, koje su dalje, u drugom stupnju, modifikovane gvožđe(III)-oksihidroksidom u obliku goetita, mangan(IV)-oksidom u formi α-MnO2 i hibridnim sistemom goetit/α-MnO2. Dobijeni materijali su skraćeno nazvani: solvotermalno sintetisan kalcit‒materijal A, kalcinisana ljuska jajeta‒materijal B, solvotermalno sintetisan kalcit/goetit‒materijal C, kalcinisana ljuska jajeta/goetit‒materijal D, solvotermalno sintetisan kalcit/α-MnO2‒materijal E, kalcinisana ljuska jajeta/α-MnO2‒materijal F, solvotermalno sintetisan kalcit/goetit/α-MnO2‒materijal G, kalcinisana ljuska jajeta/goetit/α-MnO2‒materijal H. Karakterizacija dobijenih materijala je izvršena primenom rendgenske difrakcione analize, skenirajuće elektronske mikroskopije, infracrvene spektrometrije sa Furijeovom transformacijom i metodom adsorpciono-desorpcione izoterme. Ispitivan je uticaj ultrazvučnog procesa i magnetnog mešanja na adsorpcionu efikasnost procesa. Rezultati su pokazali značajno unapređenje adsorpcionog procesa u slučaju primene ultrazvuka u odnosu na konvencionalno magnetno mešanje. Adsorpciona efikasnost ovako dobijenih materijala je ispitivana u zavisnosti od metoda funkcionalizacije, pH vrednosti rastvora, vremenskog intervala procesa, temperature, koncentracije adsorbata i uticaja...
TALEN-Mediated Gene Editing of slc24a5 (Solute Carrier Family 24, Member 5) in Kawakawa, Euthynnus affinis (2021)

Transcription activator-like effector (TALE) nucleases (TALENs) mediated gene editing methods are becoming popular and have revealed the staggering complexity of genome control during development. Here, we present a simple and efficient gene knockout using TALENs in kawakawa, Euthynnus affinis, using slc24a5. We examined slc24a5 gene expression and functional differences between two TALENs that hold the TALE scaffolds, +153/+47 and +136/+63 and target slc24a5. Developmental changes in slc24a5 transcripts were seen in early-stage embryos by real-time PCR; slc24a5 expression was first detected 48 h post fertilization (hpf), which increased dramatically at 72 hpf. Four TALENs, 47- and 63-type of two different target loci (A and B), respectively, were constructed using Platinum TALEN and evaluated in vitro by a single-strand annealing (SSA) assay. TALEN activities were further evaluated in vivo by injecting TALEN mRNAs in the two-cell stage of the zygote. Most of the TALEN-induced mutants showed mosaic patterns in the retinal pigment epithelium (RPE) and fewer melanin pigments on the body at 72 hpf and later when compared to the control, implying the gene’s association with melanin pigment formation. A heteroduplex mobility assay (HMA) and the genome sequence further confirmed the TALEN-induced mutations of substitution, insertion, and deletion at an endogenous locus.
Fourier Finite-difference Migration for 3D TTI Media (2009)

We introduce a Fourier finite-difference (FFD) method for migration by wavefield continuation in media with tilted transverse isotropy (TTI). Our TTI approximation, as its isotropic counterpart, consists of three terms: a phase-shift, a thin-lens, and fin
ChemInform Abstract: SYNTHESIS OF 2,2‐DISUBSTITUTED N‐NITROSOOXAZOLIDINES WITH NITROSYL CHLORIDE (1985)

Abstract Die im Titel genannten Verbindungen ( V) werden durch Kondensation der Alkanolamine (I) mit Aceton und nachfolgende Nitrosierung der mit den Azomethinen (IV) im Gleichgewicht stehenden Oxazolidine (III) hergestellt.
ChemInform Abstract: Theopalauamide, a Bicyclic Glycopeptide from Filamentous Bacterial Symbionts of the Lithistid Sponge Theonella swinhoei from Palau and Mozambique (1998)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Metabolic Profiling in Formalin-Fixed and Paraffin-Embedded Prostate Cancer Tissues (2017)

Metabolite profiling has significantly contributed to a deeper understanding of the biochemical metabolic networks and pathways in cancer cells. Metabolomics-based biomarker discovery would greatly benefit from the ability to interrogate retrospective annotated clinical specimens archived as formalin-fixed, paraffin-embedded (FFPE) material. Mass spectrometry-based metabolomic analysis was performed in matched frozen and FFPE human prostate cancers as well as isogenic prostate cancer cell lines. A total of 352 and 460 metabolites were profiled in human tissues and cell lines, respectively. Classes and physical-chemical characteristics of the metabolites preserved in FFPE material were characterized and related to their preservation or loss following fixation and embedding. Metabolite classes were differentially preserved in archival FFPE tissues, regardless of the age of the block, compared with matched frozen specimen, ranging from maximal preservation of fatty acids (78%) to loss of the majority of peptides and steroids. Generally, FFPE samples showed a decrease of metabolites with functional groups, such as carboxamide. As an adjunct technique, metabolic profiles were also obtained <i>in situ</i> from FFPE tissue sections where metabolites were extracted in a manner that preserves tissue architecture. Despite the fact that selected metabolites were not retained after processing, global metabolic profiles obtained from FFPE can be used to predict biologic states and study biologic pathways. These results pave the way for metabolomics-based biomarker discovery/validation utilizing retrospective and clinically annotated FFPE collections.<b>Implications:</b> Metabolic profiles can be performed in archival tissue and may be used to complement other profiling methods such as gene expression for biomarker discovery or pathway analysis in the assessment of biologic states. <i>Mol Cancer Res; 15(4); 439-47. ©2017 AACR</i>.
Tracking the emergence of antigenic variants in influenza A virus epidemics in Brazil (2023)

Influenza A virus (IAV) circulation patterns differ in North America and South America, with influenza seasons often characterized by different subtypes and strains. However, South America is relatively undersampled considering the size of its population. To address this gap, we sequenced the complete genomes of 220 IAVs collected between 2009 and 2016 from hospitalized patients in southern Brazil. New genetic drift variants were introduced into southern Brazil each season from a global gene pool, including four H3N2 clades (3c, 3c2, 3c3, and 3c2a) and five H1N1pdm clades (clades 6, 7, 6b, 6c, and 6b1). In 2016, H1N1pdm viruses belonging to a new 6b1 clade caused a severe influenza epidemic in southern Brazil that arrived early and spread rapidly, peaking mid-autumn. Inhibition assays showed that the A/California/07/2009(H1N1) vaccine strain did not protect well against 6b1 viruses. Phylogenetically, most 6b1 sequences that circulated in southern Brazil belong to a single transmission cluster that rapidly diffused across susceptible populations, leading to the highest levels of influenza hospitalization and mortality seen since the 2009 pandemic. Continuous genomic surveillance is needed to monitor rapidly evolving IAVs for vaccine strain selection and understand their epidemiological impact in understudied regions.
Polymorphisms in <i>CYP17</i> and <i>CYP3A4</i> and prostate cancer in men of African descent (2012)

Our findings suggest that genetic factors involved in the androgen pathway play a role in PCa risk among men of African ancestry.
Full-Wave Electromagnetic Scattering From Rough Surfaces With Buried Inhomogeneities (2017)

We develop a methodology for modeling coherent electromagnetic scattering from rough surfaces with buried inhomogeneities in three dimensions. The inhomogeneities considered in this paper include random spherical media, random cylindrical media, and root-like cylindrical clusters. They are used to simulate rocks, ice particles, and vegetation roots buried beneath the ground surface that can be seen by the low-frequency radars in Earth remote sensing applications. The approach we develop first calculates volumetric scattering from the media using coherent approaches, including both the conventional recursive transition matrix (T-matrix) method as well as a new generalized iterative extended boundary condition method we developed for tilted finite cylinders, and then transforms the T-matrix to the scattering matrix, which is then used to form the full scattered field of layered structures with rough surface and subsurfaces. We validate the methodology by comparing with other numerical solutions for special cases, and show sensitivity results for scattering from rough surface with buried random spherical media and random cylindrical media of different densities. We also construct a basic root model and calculate the scattering cross sections from single and multiple root clusters with or without a subsurface interface underneath. With the approach developed in this paper, we are able to study the sensitivity of radar signals to subsurface scatterers. For example, our simulations show that, depending on their density and water content, buried roots could enhance the backscatter from a single rough surface by as much as 5 dB in co-pol components, and substantially more in cross-pol components. The results of this model are expected to enable more accurate geophysical retrievals of soil moisture as well as soil organic content.