gebhart/patrepeval huggingface dataset:
Should Women Be Advised Against Pregnancy After Breast-Cancer Treatment? (1998)

Kroman, Niels; Jensen, Maj-Britt; Melbye, Mads; Wohlfahrt, Jan; Mouridsen, Henning T. Author Information
A study of flow induced by laser induced breakdown-enhanced dielectric barrier discharges in air (2013)

The flow induced by an asymmetric dielectric barrier discharge (DBD) actuator in air together with laser induced breakdown (LIB) near the exposed electrode is investigated using particle image velocimetry. In this approach, the electrodes, driven by alternating current (8 kHz, 14 kVp-p) serve primarily to accelerate the ions generated by the laser pulse (532 nm, 15 mJ per pulse, and 2 Hz). The mean velocity fields suggest that this hybrid scheme leads to a significant enhancement in the wall-jet velocity and momentum flux generated by actuation.
Optimizer time estimation for SQL queries (2018)

Predicting the amount of time a SQL query takes to execute can help in prioritizing, optimizing and scheduling the query execution. This also helps inoptimal utilization of hardware resources. The total execution time of a query can be split into the time taken for parsing/optimizing a query and the time taken for the actual execution. In this work, we focus on solving the first part of the problem, that is predicting the optimization time of a query. Predicting optimization time can hint the optimizer not to spend too much time optimizing the query in case when parse time is much higher than execution time. Such query execution plans can be cached to speed-up execution in future. If optimization time is much lower than execution time, we can choose not to cache the plan and can make better utilization of execution plan cache. If optimization time is relatively low compared to execution time, optimizer can be hinted to spend more time in parsing to produce better optimized plan which can reduce the execution time. One method towards predicting the parse time is to use some heuristic information by looking at query text. In this work, we take advantage of machine learning techniques by designing a set of features from the SQL query text and use a neural network to predict the parse time. We have tried both regression as well as classification based approaches in this work. We report high accuracy while predicting the elapsed parse time for SQL queries.
Data Analysts and Their Software Practices:A Profile of the Sabermetrics Community and Beyond (2020)

Appendix for the aforementioned paper: interview and survey material, as well as aggregated survey responses.
Properties of a human insulin receptor with a COOH-terminal truncation. II. Truncated receptors have normal kinase activity but are defective in signaling metabolic effects. (1988)

We have previously shown that a mutant human insulin receptor with a COOH-terminal 43-amino acid deletion (HIR delta CT), when expressed in Rat 1 fibroblasts, binds insulin normally, autophosphorylates, and undergoes endocytosis after insulin binding in a manner comparable to the normal human insulin receptor (HIRc). In this paper we have examined the biologic activity of the truncated and normal insulin receptors. In vitro, the HIR delta CT receptors caused a 1.8-fold greater phosphorylation of a Glu4/Tyr1 polypeptide than did the HIRc receptors, but the two receptor types were nearly equivalent in their ability to phosphorylate a src-derived peptide. Furthermore, insulin preactivation of HIRc and HIR delta CT receptors in intact cells led to equivalent stimulation of tyrosine kinase activity as subsequently determined for histone in vitro. Expression of HIRc receptors in cells led to enhanced sensitivity to insulin of 2-deoxy-D-glucose uptake and glycogen synthase activation. This increased sensitivity was proportional to receptor number at low (Ro = 6400) but not at high (Ro = 1.25 X 10(6] levels of receptor expression. However, expression of HIR delta CT receptors (Ro = 2.5 X 10(5] led to little, if any, increase in insulin sensitivity of either 2-deoxy-D-glucose uptake or glycogen synthase activation. Furthermore, compared with HIRc cells, HIR delta CT cells respond poorly to an agonistic monoclonal antibody specific for the human insulin receptor. In conclusion, the HIR delta CT receptor retains intact protein kinase activity in vitro. Despite this, however, the receptor displays low activity in mediating the metabolic effects of insulin.
Adaptive SSVEP-Based BCI System With Frequency and Pulse Duty-Cycle Stimuli Tuning Design (2013)

This study aims to design a steady state visual evoked potentials (SSVEP) based brain-computer interface (BCI) system with only three electrodes. It is known that low frequency flickering induces more intensive SSVEP, but might cause users feel uncomfortable and easily tired. Therefore, this paper proposes a novel middle/high frequency flickering stimulus. However, users show different SSVEP responses when gazing at the same stimuli. It is improper to design fixed frequency flickering stimuli for all users. This study firstly proposes a strategy to adjust the stimuli frequency for each user that could cause better SSVEP. Moreover, to further enhance the SSVEP, this study incorporates flickering duty-cycle for stimuli design, which has been discussed less for SSVEP-based BCI systems. The proposed system consists of two modes, flicker frequency/duty-cycle selection mode and application mode. The flicker frequency/duty-cycle selection mode obtains two best frequencies between 24 and 36 Hz with their related optimal duty-cycle. Then the system goes into the application mode to control the devices. A new fact that has been found is that the optimal flicker frequency and duty-cycle do not vary with time. It means once the optical flicker frequency and duty-cycle is determined the first time, flicker frequency/duty-cycle selection mode does not need to operate the next time. Furthermore, the phase coding technology is used to extend the one command/one frequency to multi command/one frequency. Experimental results show the proposed system has good performance with average accuracy 95% and average command transfer interval 4.4925 s per command.
Extracellular antigen processing and presentation by immature dendritic cells (1999)

In antigen presentation to CD4(+) T cells, proteins are degraded to peptide fragments and loaded onto class II MHC molecules in a process involving the peptide exchange factors H-2M (murine) or HLA-DM (human). In many antigen-presenting cells these processes occur in intracellular endosomal compartments, where peptides are generated and loaded onto class II MHC proteins for subsequent transport to the surface and presentation to T cells. Here, we provide evidence for an additional antigen-processing pathway in immature dendritic cells (DC). Immature DC express at the cell surface empty or peptide-receptive class II MHC molecules, as well as H-2M or HLA-DM. Secreted DC proteases act extracellularly to process intact proteins into antigenic peptides. Peptides produced by such activity are efficiently loaded onto cell surface class II MHC molecules. Together these elements comprise an unusual extracellular presentation pathway in which antigen processing and peptide loading can occur entirely outside of the cell.
Outside the limit: questioning the distance restrictions for cooperative miRNA binding sites (2023)

Among the concepts in biology that are widely taken granted is a potentiated cooperative effect of multiple miRNAs on the same target. This strong hypothesis contrasts insufficient experimental evidence. The quantity as well as the quality of required side constraints of cooperative binding remain largely hidden. For miR-21-5p and miR-155-5p, two commonly investigated regulators across diseases, we selected 15 joint target genes. These were chosen to represent various neighboring 3'UTR binding site constellations, partially exceeding the distance rules that have been established for over a decade. We identified different cooperative scenarios with the binding of one miRNA enhancing the binding effects of the other miRNA and vice versa. Using both, reporter assays and whole proteome analyses, we observed these cooperative miRNA effects for genes that bear 3'UTR binding sites at distances greater than the previously defined limits. Astonishingly, the experiments provide even stronger evidence for cooperative miRNA effects than originally postulated. In the light of these findings the definition of targetomes specified for single miRNAs need to be refined by a concept that acknowledges the cooperative effects of miRNAs.
Development and Analysis of a Folded Shorted-Patch Antenna With Reduced Size (2004)

The length of a wall-shorted rectangular patch antenna can be reduced from /spl sim//spl lambda//sub 0//4 to /spl sim//spl lambda//sub 0//8 by a simple folding operation, which results in a stacked shorted-patch (S-P) structure with a resonant frequency that can be controlled by modifying the distance between the stacked (lower and upper) shorted-patches. A theoretical analysis based on a simple transmission-line model is presented and compared with numerical simulations, showing good agreement if the height of the folded patch is much smaller than the patch length. The physical insight of the variation of the resonant frequency for this reduced-size antenna can be understood by considering the antenna as a shorted patch loaded with a capacitor. An experimental verification is carried out for a 15 mm/spl times/15 mm/spl times/6 mm folded S-P antenna prototype designed for the 2.4 GHz ISM band that can achieve a 10-dB return loss bandwidth of 4% and results in a nearly omni-directional radiation pattern.
Real-Time Demonstration of Software-Defined Elastic Interface for Flexgrid Networks (2015)

We demonstrate a real-time Elastic Interface for future flex-grid networks with a software-defined symbol rate transmission. Using PDM-QPSK modulation, live experiments show a line rate adaptation from 10.7 to 107Gbit/s with a sub-millisecond reconfiguration time.
Design of a high-performance wideband acousto-optic heterodyne channelizer (1990)

This paper reports the design and test of a high performance wideband heterodyne channelizer with low spurs due to reference-reference mixing. The measured signal to noise density ratios agree with the analytical predictions to within 1 dB in the center channels and 3 dB on the outer channels. Asymmetric optical power splitting, unequal aperture times and dual detector cancellation were utilized to achieve low spurs.
Performance Analysis of Hybrid RF-Reconfigurable Intelligent Surfaces Assisted FSO Communication (2022)

Optical reconfigurable intelligent surface (ORIS) is an emerging technology that can achieve reconfigurable optical propagation environments by precisely adjusting signal's reflection and shape through a large number of passive reflecting elements. In this article, we investigate the performance of an ORIS-assisted hybrid radio frequency (RF) and free space optics (FSO) communication system. By jointly considering the physical models of ORIS, RF channel, atmospheric turbulence, and pointing error, the closed-form solutions of the system's exact outage probability, asymptotic outage probability and BER have been derived. It is shown through numerical results that the derivation results are accurate and the RF-FSO links with ORISs show a slightly worse performance than the traditional RF-FSO links. However, the performance degradation introduced by ORIS is relatively small, and at the cost of this, the FSO link obtains a higher degree of beam adjustment freedom. We can also observe that both the increase of Rice factor in RF link and the decrease of pointing error in FSO link can effectively improve the system performance. Based on theoretical analysis and simulation results, the effect of each parameter and system design have been discussed.
Controlled Sensing with Corrupted Commands (2022)

We consider a non-adaptive controlled sensing sce-nario in which the actions of the decision maker are corrupted by an adversary. The objective of the decision maker is to either detect the presence of the corruption or make a correct decision. Accordingly, the performance of a controlled sensing strategy is measured in terms of the error probability when there is no adversary, denoted <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$P_{E,0}$</tex> , and the error probability when an adversary is present, denoted <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$P_{E,1}$</tex> . Our main result is Stein-lemma like characterization of the optimal achievable error exponent of <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$P_{E,0}$</tex> subject to a constraint on <tex xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">$P_{E,1}$</tex> . We also illustrate the result with numerical examples.
Human Alpha- and Beta-Interferon But Not Gamma- Suppress the <i>In Vitro</i> Replication of LAV, HTLV-III, and ARV-2 (1986)

The effect of human interferons (IFNs) (alpha, beta, and gamma) on the in vitro replication of AIDS viruses (LAV, HTLV-III, and ARV-2) in human peripheral blood lymphocytes was investigated. At the time of peak virus production, IFN-alpha preparations (leukocyte, Namalwa, alpha 1, and alpha 2) at 100 U/ml, suppressed LAV, HTLV-III, and ARV-2 replication as measured by reverse transcriptase (RT) activity by greater than 50%. This suppression was dose dependent and high dosages (500 U/ml) of IFN-alpha resulted in almost complete suppression of RT activities (77-99%). A low dose (100 U/ml) of IFN-beta suppressed all three AIDS viruses by 75%. In contrast, human IFN-gamma at a dose range from 100 U/ml to 500 U/ml had no significant effect on the production of infectious viruses. These results indicate that only IFN-alpha and -beta are effective against LAV, HTLV-III, and ARV-2 replication. A continuous supply of IFN appeared to be essential for the constant suppression of RT activity. In fact, upon termination of single IFN treatment, enhanced virus production resulted.
Photolysis of 3-aryl-3-(trifluoromethyl)diazirines: a caveat regarding their use in photoaffinity probes (1991)

The photolysis of 3-(4-tolyl)-3-(trifluoromethyl)diazirine in the presence of benzene, methanol, carbon tetrachloride, cyclohexane, triethylsilane, or diethylamine led to photoproducts consistent with the intermediacy of a singlet carbene. In the case of diethylamine, the photoinsertion into the N-H bond of diethylamine produced the expected adduct, 1-(diethylamino)-2,2,2-trifluoro-1-(4-tolyl)ethane. However, the base-catalyzed elimination of hydrogen fluoride from this adduct afforded an enamine, alpha-(diethylamino)-beta,beta-difluoro-4-methylstyrene, and the subsequent hydrolysis of this enamine furnished diethylamine and 2,2-difluoro-1-(4-tolyl)ethanone. This elimination and hydrolysis sequence effectively reversed the photoinsertion process. A similar photoinsertion and hydrolysis process using 3-(4-n-octylphenyl)-3-(trifluoromethyl)diazirine also produced 2,2-difluoro-1-(4-n-octylphenyl)ethanone in modest yield. These results suggest that the photoinsertion products from 3-aryl-3-(trifluoromethyl)-diazirines in biological systems may suffer similar fates limiting, in part, their utility in obtaining primary sequence data.
Abstract 1146: [18F]FPyGal: A novel ß-galactosidase specific PET tracer for <i>in vivo</i> imaging of tumor senescence (2019)

Abstract Senescence influences treatment outcome in cancer. Therefore it is of great interest to develop a diagnostic tool to detect senescent cells in cancer patients. Here we describe the evaluation of the PET tracer FPyGal for non-invasive imaging of ß-galactosidase as a surrogate marker for senescence. In vitro, we induced senescence in HCT116 cells by doxorubicin, in a liver progenitor cell line by p53-reactivation and in two liver carcinoma cell lines by a ribosomal checkpoint inhibitor (RCI). The cells were then incubated with FPyGal and tracer uptake was determined in a gamma-counter. For in vivo testing, the described cell lines were injected s.c. in mice. The tumor bearing mice were then treated appropriately to induce senescence. PET/MR scans were performed after i.v. injection of FPyGal for assessment of tracer uptake in the tumors. Ex vivo autoradiographies and X-Gal stainings were prepared to correlate intratumoral distribution of ⇓-galactosidase activity and tracer uptake. After toxicology studies, a pilot first-in-man study was performed in a cancer patient treated with Alisertib. Compared to the respective control cells, in vitro tracer uptake was significantly increased in all four cellular models tested. The strongest increase was observed in one of the liver carcinoma cell lines with a &amp;gt;3-fold increase in senescent cells. FPyGal tracer uptake increased in control HCT116 tumors from 1.1 to 1.7%ID/cc in senescent cells in in vivo PET/MRI studies and in the HRas model from 0.9 to 1.5 %ID/cc. In one of the liver tumor models we could observe a 2-fold increase in treated mice. Ex vivo ⇓-galactosidase staining and IHC of tumor tissue confirmed induction of senescence. Autoradiography and X-Gal staining showed an intratumoral correlation of ⇓-gal activity and FPyGal uptake. The compound passed the toxicology tests. A first patient study revealed high and heterogeneous tracer uptake in a liver metastasis. FPyGal shows increased in vitro and in vivo uptake in senescent cells and tumors. No toxicity of the compound could be detected and a first-in-man study showed promising results. Clinical trials including histological cross-validation are currently being prepared. Citation Format: Marcel A. Krueger, Jonathan M. Cotton, Benyuan Zhou, Katharina Wolter, Johannes Schwenck, Anna Kuehn, Kerstin Fuchs, Andreas Maurer, Christian La Fougere, Lars Zender, Bernd J. Pichler. [18F]FPyGal: A novel ß-galactosidase specific PET tracer for in vivo imaging of tumor senescence [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2019; 2019 Mar 29-Apr 3; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2019;79(13 Suppl):Abstract nr 1146.
Isolation of poliovirus 2C mutants defective in viral RNA synthesis (1988)

Two poliovirus mutants were isolated that contain an oligonucleotide linker insertion in the 2C-coding region of the viral genome. One, 2C-31, has a strongly temperature-sensitive phenotype and the other, 2C-32, forms small plaques on HeLa cell monolayers at all temperatures. Both mutants have a severe temperature-sensitive defect in viral RNA synthesis but little effect on the types of viral protein that are made. Temperature shift experiments showed that the 2C function is continuously required for viral RNA synthesis to proceed. The 2C mutants could be complemented in trans by mutants with mutations in other viral proteins. Protein 2C is also the locus of the guanidine resistance and dependence mutants, a drug whose action also affects viral RNA synthesis. Thus, protein 2C is one that is needed continually for viral RNA synthesis and, at least with these temperature-sensitive alleles, can be provided in trans.
Pemanfaatan Teknologi BREW Dengan MembangunAplikasi Kamus Bahasa (2011)

Saat ini ada banyak platform teknologi yang mendukung majunya teknologi selular dengan segala
kelebihan dan kekurangannya. Salah satu platform yang sudah lama dikenal adalah Java dengan J2ME-nya
(Java 2 Micro Edition). J2ME merupakan platform yang mendukung perangkat keras yang menjalankan
aplikasinya melalui applet Java.
Belum lama ini telah hadir teknologi BREW (Binary Runtime Environment for Wireless) sebagai
teknologi yang menyaingi J2ME dan memiliki konsep yang hampir sama dengan J2ME, dimana BREW
mendukung penuh sistem CDMA. Hadir sebagai Software Developer Kit, BREW menyediakan library-library
yang dapat dimanfaatkan untuk membangun aplikasi perangkat mobile yang tangguh.
Pada tugas akhir ini dibangun suatu aplikasi yang berguna untuk memanfaatkan teknologi BREW.
Selain itu dengan aplikasi ini dicoba untuk mengeksplorasi fitur-fitur yang disediakan oleh teknologi BREW.
Abstract 477: Correlation of PD-L1 expression and HPV status among primary and metastasized HNSCC tumors (2016)

Abstract Dysregulation of the immune checkpoints has been identified as one of the mechanisms tumor cells employ for immune escape. Human papillomavirus (HPV) plays an important role in the etiology of one subset of Head and Neck Squamous Cell Carcinomas (HNSCC). Recent studies reported that PD-1/PD-L1 pathway may be correlated with HPV-associated HNSCC. The degree of PD-L1 expression has been reported to be increased in those patients with HPV-positive disease. Also, PD-L1 expression in HNSCC was observed in the primary, recurrent, and metastatic disease setting. However, the clinicopathological implications associated with PD-L1 in HNSCC, as well as in disease metastasis, remain largely unclear. Using immunohistochemistry (IHC) and In situ hybridization (ISH) on VENTANA BenchMark ULTRA automated stainers, 40 cases of HNSCC, with matching primary and metastatic cancer stages, were evaluated for expression of PD-L1, p16, a surrogate marker of transforming HPV infections, and presence of HPV. Formalin-fixed paraffin-embedded tumor samples were subjected to PD-L1- and p16-IHC as well as HPV-ISH. A potential association between PD-L1 expression and HPV status among primary tumors and matched metastases was analyzed. Our data show that expression of PD-L1 or p16 is concordant in the majority of HNSCC primary vs metastatic tumor cases tested. Agreement rate of p16 expression among 40 case pairs of primary vs metastatic tumor was 88.2% with a 95% Confidence Interval (CI) of (73.4-95.3). PD-L1 expression was 76.9% (61.7-87.4) concordant among the 40 case pairs. Agreement rate between PD-L1 and p16 was 77.1% (61.0-87.9) in primary cases and 51.3% (35.9-66.6) in metastatic cases. No obvious association between PD-L1 and p16 expression was observed. Citation Format: Chenglu C. Quon, Xiaoling Xia, Lupe Manriquez, Crystal Schemp, Dawn Sloane, Shahad Alabagi, Mohammed G. Abdelwahab, Pengfei Gu, Lizhen Pang, Khalid Hanif, Nicole Schechter. Correlation of PD-L1 expression and HPV status among primary and metastasized HNSCC tumors. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr 477.
Faculty Opinions recommendation of Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial. (2020)

Read the full review for this Faculty Opinions recommended article: Randomized Phase II Study Evaluating Palbociclib in Addition to Letrozole as Neoadjuvant Therapy in Estrogen Receptor-Positive Early Breast Cancer: PALLET Trial.