gebhart/patrepeval huggingface dataset:
Spatial sound rendering in Max/MSP with ViMiC (2014)

Originally conceptualized [2] for the software Pure Data, ViMiC was recently refined and extended for release to the Max/MSP community. ViMiC (Virtual Microphone Control) is a tool for real-time spatialization synthesis, particularly for concert situations and site-specific im-mersive installations, and especially for larger or non-centralized audiences. Based on the concept of virtual microphones positioned within a virtual 3D room, ViMiC supports loudspeaker reproduction up to 24 discrete chan-nels for which the loudspeakers do not necessarily have to be placed uniformly and equidistant around the audience. Also, through the integrated Open Sound Control protocol (OSC), ViMiC is easily accessed and manipulated. 1.
S100A8/A9 deficiency in nonhealing venous leg ulcers uncovered by multiplexed antibody microarray profiling (2011)

The molecular anomalies in chronic wounds are more subtle than the current paradigm and neither excessive proteinase activity nor deficiencies of examined extracellular matrix proteins, growth factors or angiogenic/angiostatic factors appear to contribute significantly to the nonhealing state of venous leg ulcers.
Thio-urethanes Improve Properties of Dual-cured Composite Cements (2014)

This study aims at modifying dual-cure composite cements by adding thio-urethane oligomers to improve mechanical properties, especially fracture toughness, and reduce polymerization stress. Thiol-functionalized oligomers were synthesized by combining 1,3-bis(1-isocyanato-1-methylethyl)benzene with trimethylol-tris-3-mercaptopropionate, at 1:2 isocyanate:thiol. Oligomer was added at 0, 10 or 20 wt% to BisGMA-UDMA-TEGDMA (5:3:2, with 25 wt% silanated inorganic fillers) or to one commercial composite cement (Relyx Ultimate, 3M Espe). Near-IR was used to measure methacrylate conversion after photoactivation (700 mW/cm(2) × 60s) and after 72 h. Flexural strength and modulus, toughness, and fracture toughness were evaluated in three-point bending. Polymerization stress was measured with the Bioman. The microtensile bond strength of an indirect composite and a glass ceramic to dentin was also evaluated. Results were analyzed with analysis of variance and Tukey's test (α = 0.05). For BisGMA-UDMA-TEGDMA cements, conversion values were not affected by the addition of thio-urethanes. Flexural strength/modulus increased significantly for both oligomer concentrations, with a 3-fold increase in toughness at 20 wt%. Fracture toughness increased over 2-fold for the thio-urethane modified groups. Contraction stress was reduced by 40% to 50% with the addition of thio-urethanes. The addition of thio-urethane to the commercial cement led to similar flexural strength, toughness, and conversion at 72h compared to the control. Flexural modulus decreased for the 20 wt% group, due to the dilution of the overall filler volume, which also led to decreased stress. However, fracture toughness increased by up to 50%. The microtensile bond strength increased for the experimental composite cement with 20 wt% thio-urethane bonding for both an indirect composite and a glass ceramic. Novel dual-cured composite cements containing thio-urethanes showed increased toughness, fracture toughness and bond strength to dentin while demonstrating reduced contraction stress. All of these benefits are derived without compromising the methacrylate conversion of the resin component. The modification does not require changing the operatory technique.
Analyzing the Off-Grid Performance of the Hybrid Photovoltaic/Diesel Energy System for a Peripheral Village (2020)

Grid extension from the distribution network is being used to meet the demand for rural electricity all over the world. Due to the extra cost of extending electric lines to rural villages, it is not feasible as the installing and commissioning costs are directly related to several constraints such as distance from the main grid, the land location, utilities to be used, and the size of the approximate load. Consequently, it becomes a challenge to apply technoeconomic strategies for rural electrification. Therefore, considering the above issues of rural electrification through grid power, the renewable energy system can be an attractive solution. This research analyzes different types of loads considering domestic, industrial, and agricultural requirements for a remote village in a developing country like Bangladesh. In this paper, four types of demand scenarios are developed considering the income level of inhabitants of the village. The investigation identifies the optimal scope for renewable energy-based electrification and provides a suitable technoeconomic analysis with the help of HOMER software. The obtained results show that a combined architecture containing solar panel, diesel generator, and battery power is a viable solution and economically beneficial. The optimal configuration suggested for the primary scenario consists of 25 kW diesel generators to fulfill the basic demand. The hybrid PV-diesel-battery system becomes the optimal solution while the demand restriction is removed for secondary, tertiary, and full-option scenarios. Commercial and productive loads are considered in the load profile for these three scenarios of supply. For the primary scenario of supply, the electricity cost remains high as $0.449/kWh. On the other hand, the lowest electricity cost ($0.30/kWh) is obtained for the secondary scenario. Although the suggested optimal PV-diesel-battery might not reduce the cost of electricity (COE) and NPC significantly, it is capable to reduce dependency on diesel utilization. Hence, the emission of carbon is reduced due to less utilization of diesel that helps to minimize the greenhouse effect on the environment.
Cell and platelet adhesions on plasma glow discharge-treated poly(lactide-co-glycolide). (1997)

Surface treatment, such as plasma glow discharge treatment, onto poly(lactide-co-glycolide) (PLGA) has been investigated to improve the cell-, tissue- and blood-compatibility. Surface-treated samples were characterized by measurement with a contact angle goniometer and electron spectroscopy for chemical analysis (ESCA). The contact angles on the plasma-treated PLGA surfaces decreased with increasing plasma exposure time from 92 degrees to about 30 degrees, i.e., increased hydrophilicity. From the results of ESCA analysis of plasma-treated films, the incorporation of oxygen molecules into plasma onto the PLGA surface was observed. Cell adhesion and growth on plasma-treated PLGA surfaces were more active than on the control. Furthermore, the maximum adhesion and growth of cells in moderate hydrophilicity were investigated. Morphology of the adhered platelets on the plasma-treated PLGA surface showed less activity than on the control, and the number of adhered platelets on the plasma-exposed PLGA sample decreased with decreasing water contact angle. It seems that surface wettability of PLGA plays an important role in cell adhesion, spreading and growth, and platelet adhesion.
Genome-wide gene expression profiling to predict resistance to anthracyclines in breast cancer patients (2013)

Validated biomarkers predictive of response/resistance to anthracyclines in breast cancer are currently lacking. The neoadjuvant Trial of Principle (TOP) study, in which patients with estrogen receptor (ER)-negative tumors were treated with anthracycline (epirubicin) monotherapy, was specifically designed to evaluate the predictive value of topoisomerase II-alpha (TOP2A) and develop a gene expression signature to identify those patients who do not benefit from anthracyclines. Here we describe in details the contents and quality controls for the gene expression and clinical data associated with the study published by Desmedt and colleagues in the Journal of Clinical Oncology in 2011 (Desmedt et al., 2011). We also provide R code to easily access the data and perform the quality controls and basic analyses relevant to this dataset.
Damage and Micropattem Formation in Ge-Sb-Te Phase Change Materials Induced by Intense Terahertz Pulse Train (2018)

Intense terahertz radiation is promising for material control and understanding of the THz-matter interactions is important research topic. We irradiated Ge-Sb- Te phase change material thin films with a train of THz pulses from a free electron laser and found that the surface changes that are damage as a precursor to ablation and the undulations were induced without amorphization. The undulation pattern is thought to be a sort of laser induced periodic structure (LIPSS) that is one of important phenomena in the field of laser material processing. Absence of amorphization implies that photo- or electrical-excitation plays an important role for fast phase change operation.
O04.4 <i>Mycoplasma genitalium parC and gyrA</i>mutations associated with moxifloxacin and sitafloxacin treatment failure (2019)

<h3>Background</h3> There has been a rapid increase in the resistance of <i>Mycoplasma genitalium</i> to first line (azithromycin) and second line (fluoroquinolone) therapy, particularly in the Asia-Pacific region. While mutations conferring resistance to azithromycin are well established, this is not the case for fluoroquinolones. We aimed to define mutations associated with fluoroquinolone failure to inform next generation resistance assays. <h3>Methods</h3> Samples from patients undergoing resistance-guided therapy with either moxifloxacin (Apr-2017–Jun-2018, 202 cases: 21 moxifloxacin failures) or sitafloxacin (Jun-2016–May-2017, 125 cases:12 sitafloxacin failures) were sequenced for key regions of <i>parC</i> and <i>gyrA</i> genes. Chi-square or Fisher’s exact tests were used to examine prevalence of each mutation and treatment outcome. <h3>Results</h3> In an interim analysis the most common <i>parC</i> mutations were G248T (amino acid change S83I; 16%), G259A (D87N; 4%), G248A (S83N; 1%) and mutations effecting S83R (1%). G248T (S83I) mutation was more common among patients that failed moxifloxacin [15/21 failures (71%) vs 11/181 cures (6%), p&lt;0.001] and sitafloxacin [6/12 failures (50%) vs 19/113 cures (17%), p=0.0063]. Notably, sitafloxacin cured a higher proportion of infections carrying the S83I mutation than moxifloxacin (76% vs 42%; p=0.015). ParC D87N was not associated with failure of moxifloxacin [1/21 failures (5%) vs 11/181 cures (6%)]. The most common <i>gyrA</i> mutations were G285A (M95I; 5%) and G295T (D99Y; 1%). An infection with an S83I mutation was more likely to fail treatment when combined with a <i>gyrA</i> mutation (M95I or D99N) (4/6 sitafloxacin failures with <i>parC</i> S83I also had <i>gyrA</i> mutation, compared to 1/16 cures; p=0.0093), suggesting an additive effect. <h3>Conclusion</h3> This study provides compelling evidence that <i>parC</i> G248T (S83I) mutations contribute to failure of moxifloxacin and sitafloxacin used for macrolide-resistant <i>M. genitalium</i>. These data will inform the development of quinolone resistance assays needed to ensure optimal selection of antimicrobials in <i>M. genitalium</i>. <h3>Disclosure</h3> No significant relationships.
Behavior of flexible poly(vinyl chloride)/poly(hydroxybutyrate valerate) blends (2008)

Abstract Blends of flexible poly(vinyl chloride) (PVC) and a poly(hydroxybutyrate valerate) (PHBV) copolymer were prepared and characterized with different techniques. The tensile strength of PVC did not show a marked reduction at PHBV concentrations up to 50 phr, despite a lack of miscibility between the two polymers. The crystallization of the PHBV copolymer was markedly hindered by the presence of PVC, as calorimetric results revealed. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008
Hydrogen‐Bonded CdS Nanoparticle Assemblies on Electrodes for Photoelectrochemical Applications (2005)

Effizienzsteigerung: Die Photostromausbeute wird durch H-Brücken-gebundene Anordnungen aus Goldnanopartikeln und CdS-Nanopartikeln auf einer Goldelektrodenoberfläche erhöht (siehe Schema). Ursache sind eine Ladungstrennung und ein kontrollierter Elektronentransfer an der Elektrodengrenzfläche.
Unexpected diversity in populations of the many‐celled magnetotactic prokaryote (2006)

The many-celled magnetotactic prokaryote (MMP) is an uncultivated, highly motile aggregate of 10-30 cells containing numerous chains of greigite (Fe(3)S(4)) magnetosomes. It is unique to marine environments and is abundant in slightly sulfidic sediments of the Little Sippewissett salt marsh (Falmouth, MA). We sequenced 16s rDNA genes from a natural population of MMP and found five lineages separated by at least 5% sequence divergence. Fluorescent in situ hybridization probes for three of these lineages showed significant variation in their relative abundances across a seasonal cycle in marsh productivity. The MMP should therefore be considered a separate genus in the delta-proteobacteria rather than a single species as previously thought. All cells in each aggregate express identical SSU rRNAs, suggesting that the aggregates are composed of a single MMP phylotype. This observation supports a model of the MMP as comprised of clonal cells which reproduce by binary fission of the aggregate.
High transmittance pixel structure for the multidomain vertical alignment mode (2012)

We propose a new pixel structure to improve the transmittance at the pixel boundaries. By forming additional electrodes at the pixel boundaries, LCs at the pixel boundaries can be aligned to 45° against the transmission axes (TA) of the polarizers for high transmittance.
Plan de negocios para la creación de una empresa dedicada a la producción y exportación de alcohol etílico orgánico (2010)

The organic alcohol ethyl is a product that is obtained from the sugar cane which is cultivated in an organic way by small Ecuadorian communities. It is a product that generates added organic value towards the directed industry. Ecuador has favorable conditions to grow sugar cane, which is the most efficient raw material to obtain alcohol ethyl. According to a marketing research, the United States is the principal buyer in the world of alcohol ethyl with a growth rate of 53 percent in the last 5 years. This raw material is used in the Cosmetic, Pharmaceutical, Chemical and Fuel Industries as well as for culinary ends. Since 2007, the Central Bank of Ecuador has qualified the Ecuadorian alcohol ethyl among the ten products with the most potential in The United States market. Based on these characteristics, the idea of ALORGANIX started. ALORGANIX is a company that produces and exports organic alcohol ethyl. The aim is to compete in the United States market with a high quality product at competitive prices. As a result, it is expected to obtain a growth in the sales of 50 percent in the first five years. Through a financial analysis, we have reached to the conclusion that company will present high profitability, with a NPV of 43,515.33 and an IRR of 44, 29 percent in the normal scenario. In this way, ALORGANIX will generate work and wealth for the partners and personnel that will be involved in the concept which at the same time will create sustainability in future.
Multi-Terminal HVDC System With Offshore Wind Farms Under Anomalous Conditions: Stability Assessment (2021)

Droop control is widely adopted to control Multi-Terminal high-voltage Direct Current (MTDC) systems with offshore wind farms. During permanent faults, the faulty line should be isolated promptly to preserve a high reliability of the MTDC system. This paper examines the MTDC system performance following a faulty line outage. This study aims to identify the outage types that may lead to a complete loss of system voltage stability and the outages that may have a secondary effect on the system. Moreover, strategies for dealing with outages that may lead to a complete shutdown of the system are also presented. Furthermore, the ranges of droop gains’ values that can be employed following fault occurrence to preserve system transient stability are studied. Different scenarios are explored during faulty conditions such as surplus and sparsity of wind power, line overcurrent, outage of lines connected to wind farms, and outage of lines connected to AC grids to validate this study. MATLAB/Simulink platform has been employed to elucidate the presented concept.
Breadth and function of antibody response to acute SARS-CoV-2 infection in humans (2021)

Serological and plasmablast responses and plasmablast-derived IgG monoclonal antibodies (MAbs) have been analysed in three COVID-19 patients with different clinical severities. Potent humoral responses were detected within 3 weeks of onset of illness in all patients and the serological titre was elicited soon after or concomitantly with peripheral plasmablast response. An average of 13.7% and 3.5% of plasmablast-derived MAbs were reactive with virus spike glycoprotein or nucleocapsid, respectively. A subset of anti-spike (10 of 32) antibodies cross-reacted with other betacoronaviruses tested and harboured extensive somatic mutations, indicative of an expansion of memory B cells upon SARS-CoV-2 infection. Fourteen of 32 anti-spike MAbs, including five anti-receptor-binding domain (RBD), three anti-non-RBD S1 and six anti-S2, neutralised wild-type SARS-CoV-2 in independent assays. Anti-RBD MAbs were further grouped into four cross-inhibiting clusters, of which six antibodies from three separate clusters blocked the binding of RBD to ACE2 and five were neutralising. All ACE2-blocking anti-RBD antibodies were isolated from two recovered patients with prolonged fever, which is compatible with substantial ACE2-blocking response in their sera. Finally, the identification of non-competing pairs of neutralising antibodies would offer potential templates for the development of prophylactic and therapeutic agents against SARS-CoV-2.
SLCs contribute to endocrine resistance in breast cancer: role of SLC7A5 (LAT1) (2019)

Abstract Resistance to endocrine therapies remains a major challenge for the successful management of patients with estrogen receptor-positive (ER+) breast cancers. Central to the development of resistance is the adaptive reprogramming of cellular metabolism in response to treatment. Solute carriers (SLCs) play a key role in metabolic reprogramming by transporting sugars, amino acids, and other nutrients and regulating their abundance within the cell and its subcellular organelles. We found 109 SLC mRNAs to be differentially expressed between endocrine sensitive and resistant breast cancer cells. In univariate analyses, 55 of these SLCs were associated with poor outcome in ER+ breast cancer patients. Data from TMT and SILAC studies then led us to focus on SLC7A5 (LAT1). In complex with SLC3A2 (CD98), LAT1 is the primary transporter of large, neutral amino acids including leucine and tyrosine. LAT1 expression is estrogen-regulated in endocrine sensitive cells but this regulation is lost in resistant cells. Pharmacologic inhibition or genetic depletion of LAT1 each suppressed growth in two models of endocrine resistant breast cancer. Autophagy was activated with LAT1 inhibition, but cells failed to degrade p62 showing that flux was blocked. Overexpression of the LAT1 cDNA increased protein synthesis and high LAT1 expression correlated with poor disease-free survival in ER+ breast cancer patients. This study uncovers a novel LAT1 mediated adaptive response that contributes to the development of endocrine resistance. Blocking LAT1 function may offer a new avenue for effective therapeutic intervention against endocrine resistant ER+ breast cancers.
The Next Breakthrough for Organic Photovoltaics? (2014)

While the intense focus on energy level tuning in organic photovoltaic materials has afforded large gains in device performance, we argue here that strategies based on microstructural/morphological control are at least as promising in any rational design strategy. In this work, a meta-analysis of ∼150 bulk heterojunction devices fabricated with different materials combinations is performed and reveals strong correlations between power conversion efficiency and morphology-dominated properties (short-circuit current, fill factor) and surprisingly weak correlations between efficiency and energy level positioning (open-circuit voltage, enthalpic offset at the interface, optical gap). While energy level positioning should in principle provide the theoretical maximum efficiency, the optimization landscape that must be navigated to reach this maximum is unforgiving. Thus, research aimed at developing understanding-based strategies for more efficient optimization of an active layer microstructure and morphology are likely to be at least as fruitful.
Development of indicators for a comprehensive assessment of the intellectualization of machine production of vegetable crops (2020)

Vegetable growing is an important branch of agricultural production. Among the many vegetable plants, more and more importance is given to crops whose products contain physiologically active substances. These crops include nightshade vegetables - tomatoes, bell peppers, eggplants and onions. For the production of vegetable crops, complexes of special and universal machines are used. Universal vehicles include general-purpose vehicles, energy vehicles of various traction classes, special vehicles - planting equipment, cultivators, irrigation machines, chemical protection. The intensity of agriculture in modern production conditions is impossible without a high level of saturation of machine-technological complexes with intellectualization. Obtaining high-quality competitive products is possible only with the use of modern high-performance machines that ensure the combination of technological operations, the design of which includes automated process control systems, soil fertility accounting, and ensuring ecological cleanliness of agricultural landscapes. The use of intelligent technologies is becoming a global trend in modern agricultural production, when during performing technological operations, large amounts of information is collected and processed. Technical means and machines for the implementation of such technologies should also have a certain degree of intelligence, should be equipped with devices for collecting, processing and transmitting information, making decisions on certain algorithms and implementing management decisions. The article presents the results of studies determining indicators of a comprehensive assessment of the intellectualization of machine production of vegetable crops.
GPR183 mediates the capacity of the novel CD47-CD19 bispecific antibody TG-1801 to heighten ublituximab-umbralisib (U2) anti-lymphoma activity (2022)

Abstract Targeted therapies have considerably improved the survival rate of B-cell non-Hodgkin lymphoma (B-NHL) patients in the last decade; however, most subtypes remain incurable. TG-1801, a bispecific antibody that targets CD47 selectively on CD19+ B-cells, is under clinical evaluation in relapsed/refractory B-NHL patients either as a single-agent or in combination with ublituximab, a CD20 antibody, which is also being combined with the PI3Kδ/CK1e inhibitor, umbralisib (“U2”-regimen). In this study, we demonstrated that TG-1801 potentiates ublituximab-mediated antibody-dependent cell death (ADCC) and antibody-dependent cell phagocytosis (ADCP), leading to an additive anti-tumour effect of the TG-1801/U2 combination in B-NHL co-cultures. Accordingly, in a B-NHL xenotransplant model, the triplet achieved a 93% tumour growth inhibition, with 40% of the animals remaining tumour-free 35 days after the last dosing. Transcriptomic analysis further uncovered the upregulation of the G protein-coupled receptor, GPR183, as a crucial event associated with TG-1801/U2 synergism, while pharmacological blockade or genetic depletion of this factor impaired ADCP initiation, as well as cytoskeleton remodelling and cell migration, in B-NHL cultures exposed to the drug combination. Thus, our results set the preclinical rationale and support a combination strategy of TG-1801 with PI3Kδ- and CD20-targeting agents in patients with B-NHL.