gebhart/patrepeval huggingface dataset:
Synthesis, Characterisation, and Molecular Structures of New Ferrocenyl Schiff Bases and their Aluminium and Zinc Complexes (2001)

The aldimines FcCH=NCH(Me)CH2OMe (1), FcCH=NCH2H6H4-2-OMe (2) and FcCH=N(CH2)3NHMe (3) were obtained by reacting ferrocene aldehyde with the corresponding primary amines. Compounds 1–3 react with Me2Zn and Me3Al in a molar ratio 1 : 1 to the corresponding adducts 4–8. Reactions of 1 and 2 with t-butyllithium lead to an addition of the lithium reagent yielding the corresponding amides 9 and 10. Compounds 1–10 were characterised by 1H- and 13C-NMR spectroscopy. The molecular structures of 1, 2, 4, 5, 9 and 10 were determined by X-ray diffraction. 4 consists of monomeric molecules, containing a four-coordinated Zn atom as a result of Zn–O and Zn–N interactions. In contrast to 4 the Al atom in 5 is coordinated by the N atom of the ligand only. 9 and 10 form dimeric molecules with four-coordinated Li atoms as the general structural feature. Synthese, Charakterisierung und Molekülstrukturen neuer Ferrocenyl Schiff Basen und deren Aluminium- und Zinkkomplexe Die Aldimine FcCH=NCH(Me)CH2OMe (1), FcCH=NCH2H6H4-2-OMe (2) und FcCH=N(CH2)3NHMe (3) wurden durch Reaktion von Ferrocenaldehyd mit den entsprechenden primären Aminen erhalten. 1–3 reagieren mit Me2Zn und Me3Al im Molverhältnis 1 : 1 zu den Addukten 4–8. Reaktionen von 1 und 2 mit t-Butyllithium führen unter Addition der Lithiumverbindung an die C=N-Doppelbindung zu den Amiden 9 und 10. Die Komplexe 1–10 wurden durch 1H- und 13C-NMR-Spektroskopie charakterisiert. Die Molekülstrukturen von 1, 2, 4, 5, 9 und 10 wurden bestimmt. 4 bildet monomere Moleküle mit 4-fach koordinierten Zn-Atomen, als Ergebnis von Zn–O und Zn–N-Wechselwirkungen. Im Gegensatz dazu wird das Al-Atom in 5 nur durch das N-Atom des Liganden koordiniert. 9 und 10 liegen im festen Zustand als dimere Moleküle, mit 4-fach koordinierten Li-Atomen, vor.
Capture and Expansion of Bone Marrow-Derived Mesenchymal Progenitor Cells with a Transforming Growth Factor- <i>β</i> 1–von Willebrand's Factor Fusion Protein for Retrovirus-Mediated Delivery of Coagulation Factor IX (1997)

Mesenchymal stem cells give rise to the progenitors of many differentiated phenotypes, including osteocytes, chrondocytes, myocytes, adipocytes, fibroblasts, and marrow stromal cells, which are capable of self-renewal and undergo expansion in the presence of transforming growth factor-beta1 (TGF-beta1). The present study was designed to test the concept that mesenchymal progenitor cells could be selected and expanded by virtue of their intrinsic physiologic responses to TGF-beta1. Human bone marrow aspirates were initially cultured, under low serum conditions, in collagen pads or gels impregnated with a genetically engineered TGF-beta1 fusion protein bearing an auxiliary von Willebrand's factor-derived collagen-binding domain (TGF-beta1-vWF). Histologic examination of TGF-beta1-vWF-supplemented collagen pads from 8-day cultures revealed the selective survival of a population of mononuclear blastoid cells. The TGF-beta-responsive cells were expanded to form stromal/fibroblastic colonies by serum reconstitution, and further to form osteogenic colonies upon supplementation with osteoinductive factors. In comparative studies, both marrow-derived progenitor cells and mature stromal cells were transduced with a retroviral vector bearing a human factor IX construct. Both the transduced progenitor cells and mature stromal cells expressed the factor IX transgene at levels comparable to those reported for human fibroblasts. Transplantation of murine progenitor cells bearing the human factor IX vector into syngeneic B6CBA mice resulted in detectable circulating levels of the human factor IX antigen. Taken together, these data demonstrate a novel physiologic approach for the selection of mesenchymal precursor cells followed by mitotic expansion, transduction, and transplantation of these progenitor cells with retroviral vectors bearing therapeutic genes.
Supplementary Table S1 from IGF2 Preserves Osteosarcoma Cell Survival by Creating an Autophagic State of Dormancy That Protects Cells against Chemotherapeutic Stress (2023)

&lt;p&gt;Supplementary Table S1. Sequences of primers and predicted product sizes for real-time RT-PCR analysis&lt;/p&gt;
Etude polarographique de l'antimoine(III) et (V) dans le fluorure d'hydrogène anhydre et dans ses mélanges avec l'eau (1978)

The electrochemical behaviour of Sb(III) and Sb(V) in water–HF mixtures (2.5 to 50% HF) and in anhydrous HF is described. A Teflon capillary dropping mercury electrode is proposed for polarographie investigations in these fluorinated media. It is shown, by classical or puise polarography, that Sb(III) can be reduced to Sb(0), as in acidic non-fluorinated media. The electrochemical reaction becomes reversible by addition of Cl − , Br − or I − . Sb(V) is not electroactive in the various HF-media, except when it is introduced as the SbCl 5 . In this case, the two polarographie waves of Sb(V) disappear with time because of SbF 6 − formation. Analytical applications to the determination of Sb(III) in water–HF and in anhydrous HF are discussed.
Metasurface Integrated Monolayer Exciton Polariton (2020)

Monolayer transition-metal dichalcogenides (TMDs) are the first truly two-dimensional (2D) semiconductor, providing an excellent platform to investigate light-matter interaction in the 2D limit. The inherently strong excitonic response in monolayer TMDs can be further enhanced by exploiting the temporal confinement of light in nanophotonic structures. Here, we demonstrate a 2D exciton-polariton system by strongly coupling atomically thin tungsten diselenide (WSe<sub>2</sub>) monolayer to a silicon nitride (SiN) metasurface. Via energy-momentum spectroscopy of the WSe<sub>2</sub>-metasurface system, we observed the characteristic anticrossing of the polariton dispersion both in the reflection and photoluminescence spectrum. A Rabi splitting of 18 meV was observed which matched well with our numerical simulation. Moreover, we showed that the Rabi splitting, the polariton dispersion, and the far-field emission pattern could be tailored with subwavelength-scale engineering of the optical meta-atoms. Our platform thus opens the door for the future development of novel, exotic exciton-polariton devices by advanced meta-optical engineering.
Traversing Steep and Granular Martian Analog Slopes with a Dynamic Quadrupedal Robot (2022)

Celestial bodies, such as the Moon and Mars are mainly covered by loose, granular soil, which is a notoriously challenging terrain to traverse with wheeled robots. Here, we present experimental work on traversing steep, granular slopes with the dynamically-walking quadrupedal robot SpaceBok. To adapt to the challenging environment, we developed passive-adaptive, planar feet and optimized studs to reduce sinkage and increase traction. Single-foot experiments revealed that a surface area of 110 cm 2 per foot reduces sinkage to an acceptable level for the 22 kg robot, even on highly collapsible soil. Implementing several 12 mm studs increases traction by 22% to 66% on granular media compared to stud-less designs. Together with a terrain-adapting walking controller, we validate -for the first time -static and dynamic locomotion on Mars analog slopes of up to 25(the maximum of the testbed). We evaluated the performance between point-and planar feet and static and dynamic gaits for safety, velocity, and energy consumption. We show that dynamic gaits are energetically more efficient than static ones, but are riskier on steep slopes. Our tests also revealed that energy consumption with planar feet increases drastically as slope inclination approaches the soil's angle of repose. Point feet are less affected by slippage due to their excessive sinkage but, in turn, are prone to instabilities and tripping. Based on our findings, we present safe and energy-efficient, global, path-planning strategies for negotiating steep Martian topography.
Anti-HBc-Ig-M: Ein früher Parameter der HBV-Infektion (1980)

Die Kinetik des Anti-HBc wurde erstmals von Hoofnagle et al. 1974 untersucht: Das Anti-HBc wird 2 Wochen nach dem Auftreten des HBs-Antigens positiv. Hoofnagle verwandte zum Nachweis des Anti-HBc die KBR.
Responses of polar organic compounds to different ionic environments in aqueous media are interrelated (2014)

Solubilities of 17 polar organic compounds in aqueous solutions of Na2SO4, NaCl, NaClO4, and NaSCN at the salt concentrations of up to 1.0-2.0 M were determined and the Setschenow constant, ksalt, values were estimated. It was found that NaClO4 may display both salting-in and salting-out effects depending on the particular compound structure. The Setschenow constant values for all the polar compounds examined in different salt solutions are found to be interrelated. Similar relationships were observed for partition coefficients of nonionic organic compounds in aqueous polyethylene glycol-sodium sulfate two-phase systems in the presence of different salt additives reported previously [Ferreira et al., J. Chromatogr. A, 2011, 1218, 5031], and for the effects of different salts on optical rotation of amino acids reported by Rossi et al. [J. Phys. Chem. B, 2007, 111, 10510]. In order to explain the observed relationships it is suggested that all the effects observed originate as responses of the compounds to the presence of a given ionic environment and its interaction with the compounds by forming direct or solvent-separated ionic pairs. The response is compound-specific and its strength is determined by the compound structure and the type (and concentration) of ions inducing the response.
Phase II open label, multi‐center clinical trial of modulation of intermediate endpoint biomarkers by 1α‐hydroxyvitamin D2 in patients with clinically localized prostate cancer and high grade pin (2013)

While further investigation of vitamin D may be warranted based on preclinical studies, results of the present trial do not appear to justify evaluation of 1α-OH-D2 in larger clinical prostate cancer prevention studies.
HALO 109-301: A randomized, double-blind, placebo-controlled, phase 3 study of pegvorhyaluronidase alfa (PEGPH20) + nab-paclitaxel/gemcitabine (AG) in patients (pts) with previously untreated hyaluronan (HA)-high metastatic pancreatic ductal adenocarcinoma (mPDA). (2020)

638 Background: HA is a major component of the tumor microenvironment (TME) in PDA. PEGPH20 degrades tumor HA, remodeling the TME. In PDA models, PEGPH20 has shown antitumor activity and increased TME delivery of anticancer agents to improve efficacy. A randomized phase 2 study showed promising results for PEGPH20+AG (PAG) in mPDA and identified HA accumulation as a biomarker. We present results from a phase 3 study (NCT02715804) of PAG for pts with HA-high mPDA. Methods: Pts ≥18 years with untreated HA-high mPDA were randomized (stratified by geographic region) 2:1 to PAG or placebo+AG (AG). HA status was prospectively determined with VENTANA HA RxDx Assay, with HA-high defined as ≥50% staining of a tumor sample. Treatment was administered IV in 4-wk cycles (3 wks on, 1 wk off) until progression or intolerable adverse events (AEs): PEGPH20 3.0 µg/kg twice wkly for Cycle 1 and once wkly (QW) thereafter, A 125 mg/m 2 QW and G 1000 mg/m 2 QW. Prophylactic enoxaparin 1 mg/kg was given daily for thromboembolism (TE) risk. The primary endpoint was overall survival (OS); secondary endpoints included progression-free survival (PFS), objective response rate (ORR) and safety. Response was independently assessed per RECIST v1.1. The estimated sample size was ~500 pts to detect a hazard ratio (HR) for OS of 0.67 (93% power, 2-sided α = 0.05) after 330 deaths. Results: As of 20 May 2019, 494 pts were randomized with 492 (327 for PAG and 165 for AG) included in ITT analyses (2 pts excluded due to site violations). Baseline characteristics were balanced for PAG vs AG. After 330 deaths, median OS for PAG vs AG was 11.2 vs 11.5 mo (HR 1.00, 95% CI 0.80–1.27; P = 0.97); median PFS was 7.1 vs 7.1 mo (HR 0.97, 95% CI 0.75–1.26); confirmed ORR was 34% vs 27%. Grade (G) 3+ AEs (PAG vs AG) included neutropenia (44% vs 47%), thrombocytopenia (21% vs 16%) and fatigue (16% vs 10%); G3+ rates were 6% vs 7% for TE events, 5% vs 2% for bleeding events and 13% vs 5% for musculoskeletal events. Conclusions: PAG did not improve clinical outcomes vs AG. The PAG safety profile was consistent with that of previous studies. Clinical trial information: NCT02715804.
&lt;title&gt;Architectural impact of patterned-overlay multichip module technologies&lt;/title&gt; (1993)

The advent of highly advanced multi-chip module (MCM) technologies makes it feasible to consider higher performance computer architectures optimized for a particular packaging approach. In particular, the High Density Interconnect (HDI) technology and related patterned overlay technologies allow for high bandwidth topologies to be constructed which are beyond the reach of many other packaging technologies. Through the use of the recently developed three-dimensional extensions of the HDI process, even more aggressive computer designs can be undertaken. Variations of the physical topologies that can be constructed with the two- and three-dimensional HDI processes provoke new paradigms in future high-performance computer construction.
Promising Accurate Prefix Boosting for sequence-to-sequence ASR (2018)

In this paper, we present promising accurate prefix boosting (PAPB), a discriminative training technique for attention based sequence-to-sequence (seq2seq) ASR. PAPB is devised to unify the training and testing scheme in an effective manner. The training procedure involves maximizing the score of each partial correct sequence obtained during beam search compared to other hypotheses. The training objective also includes minimization of token (character) error rate. PAPB shows its efficacy by achieving 10.8\% and 3.8\% WER with and without RNNLM respectively on Wall Street Journal dataset.
Creating connections – the development of a mobile-health monitoring system for heart failure: Qualitative findings from a usability cohort study (2016)

Users' patterns of engagement with health technology changes over time and varies according to their need and capacity to use the technology. Incorporating diverse user experiences in the development and maintenance of mobile-health systems is likely to increase the extent of successful uptake and impacts on outcomes for patients and providers.
Buck and Boost Converters [Circuit Intuitions] (2021)

Welcome to the 30th article in the “Circuit Intuitions” column series. As the title suggests, each installment provides insights and intuitions into circuit design and analysis. These articles are aimed at undergraduate students but may serve the interests of other readers, as well. If you read this article, I would appreciate your comments and feedback as well as your requests and suggestions for future installments in this series. Please email me your comments: ali@ece.utoronto.ca.
Factors influencing cell fatty acid composition and A40926 antibiotic complex production in Nonomuraea sp. ATCC 39727 (2008)

A40926 is a glycopeptide antibiotic complex consisting of several structurally related factors. It is produced by fermentation of Nonomuraea sp. ATCC 39727 and the complex components differ in the structure of the fatty acid moiety linked to the aminoglucuronic acid unit. In previous work, we observed that the production of single factors in glycopeptide antibiotic complexes could be selectively enhanced by the addition of suitable precursors to the culture medium. In this contribution, we examine the effects of branched amino acid addition to fermentation of Nonomuraea sp. in a chemically defined minimal medium. The changes in the composition of cell fatty acids correlate to the fatty acid distribution within the A40926 complex in diverse cultivation conditions. Nonomuraea sp. prefers isobutyric, butyric and propionic acids as initiators of fatty acid biosynthesis. The relative amount of the produced fatty acids is significantly influenced by the availability of intermediates or final products from the amino acid catabolic pathways. Antibiotic complex composition closely reflects the cell fatty acid pattern, in agreement with the assumption that the antibiotic fatty acid moieties are synthesized by shortening the chain of cell fatty acids.
La Tordeuse, Dichelia cedricola Diakonoff, un ravageur d'Asie mineure potentiellement important pour le Cèdre en France. (2001)

La tordeuse, Dichelia cedricola, est un défoliateur de Cedrus libani en Asie Mineure. Dans cet article, nous faisons le point sur sa répartition géographique, sa biologie et l'importance de ses dégâts. Elle est potentiellement dangereuse pour le Cèdre en France. Des différences biologiques permettent de distinguer les tordeuses consommatrices d'aiguilles recensées à ce jour sur le genre Cedrus dans le bassin méditerranéen.
High Quality Factor Photonic Crystal Nanobeam Cavities and Their Applications (2009)

Wavelength-scale and high-Q photonic crystal resonators made in various materials (Si, Si3N4, III-Vs), as well as their application in novel single-photon sources and nonlinear wavelength conversion at single-photon level, will be discussed.
Elaboración de Membranas Poliméricas Porosas a partir de Cristales Coloidales (2010)

Se elaboraron membranas poliméricas porosas con elevado control de la morfología y de los tamaños de poros a partir de cristales coloidales constituidos por partículas de sílice. El método empleado permite obtener diferentes morfologías dependiendo del tamaño de las partículas y del número de capas involucradas en los depósitos. Para la síntesis de las partículas se emplearon dos métodos, originándose distintos tamaños. Los cristales coloidales se obtuvieron por deposición vertical de las partículas sobre un sustrato de vidrio y por la técnica de Langmuir-Blodgett. Se fabricaron membranas de poliestireno (PS) y de copolímero de estireno (St)-vinil bencil timina (VBT). El procedimiento involucró la infiltración de los monómeros seguida por la polimerización por irradiación con luz UV. El método propuesto provee una alternativa relativamente simple, muy versátil y a la vez económica para la elaboración de polímeros macroporosos.
The Atypical Stimulant and Nootropic Modafinil Interacts with the Dopamine Transporter in a Different Manner than Classical Cocaine-Like Inhibitors (2011)

Modafinil is a mild psychostimulant with pro-cognitive and antidepressant effects. Unlike many conventional stimulants, modafinil has little appreciable potential for abuse, making it a promising therapeutic agent for cocaine addiction. The chief molecular target of modafinil is the dopamine transporter (DAT); however, the mechanistic details underlying modafinil's unique effects remain unknown. Recent studies suggest that the conformational effects of a given DAT ligand influence the magnitude of the ligand's reinforcing properties. For example, the atypical DAT inhibitors benztropine and GBR12909 do not share cocaine's notorious addictive liability, despite having greater binding affinity. Here, we show that the binding mechanism of modafinil is different than cocaine and similar to other atypical inhibitors. We previously established two mutations (W84L and D313N) that increase the likelihood that the DAT will adopt an outward-facing conformational state--these mutations increase the affinity of cocaine-like inhibitors considerably, but have little or opposite effect on atypical inhibitor binding. Thus, a compound's WT/mutant affinity ratio can indicate whether the compound preferentially interacts with a more outward- or inward-facing conformational state. Modafinil displayed affinity ratios similar to those of benztropine, GBR12909 and bupropion (which lack cocaine-like effects in humans), but far different than those of cocaine, β-CFT or methylphenidate. Whereas treatment with zinc (known to stabilize an outward-facing transporter state) increased the affinity of cocaine and methylphenidate two-fold, it had little or no effect on the binding of modafinil, benztropine, bupropion or GBR12909. Additionally, computational modeling of inhibitor binding indicated that while β-CFT and methylphenidate stabilize an "open-to-out" conformation, binding of either modafinil or bupropion gives rise to a more closed conformation. Our findings highlight a mechanistic difference between modafinil and cocaine-like stimulants and further demonstrate that the conformational effects of a given DAT inhibitor influence its phenomenological effects.
Human Induced Pluripotent Stem Cell–Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation (2015)

Glomerular podocytes express proteins, such as nephrin, that constitute the slit diaphragm, thereby contributing to the filtration process in the kidney. Glomerular development has been analyzed mainly in mice, whereas analysis of human kidney development has been minimal because of limited access to embryonic kidneys. We previously reported the induction of three-dimensional primordial glomeruli from human induced pluripotent stem (iPS) cells. Here, using transcription activator-like effector nuclease-mediated homologous recombination, we generated human iPS cell lines that express green fluorescent protein (GFP) in the NPHS1 locus, which encodes nephrin, and we show that GFP expression facilitated accurate visualization of nephrin-positive podocyte formation in vitro These induced human podocytes exhibited apicobasal polarity, with nephrin proteins accumulated close to the basal domain, and possessed primary processes that were connected with slit diaphragm-like structures. Microarray analysis of sorted iPS cell-derived podocytes identified well conserved marker gene expression previously shown in mouse and human podocytes in vivo Furthermore, we developed a novel transplantation method using spacers that release the tension of host kidney capsules, thereby allowing the effective formation of glomeruli from human iPS cell-derived nephron progenitors. The human glomeruli were vascularized with the host mouse endothelial cells, and iPS cell-derived podocytes with numerous cell processes accumulated around the fenestrated endothelial cells. Therefore, the podocytes generated from iPS cells retain the podocyte-specific molecular and structural features, which will be useful for dissecting human glomerular development and diseases.
Fatty acid profile remodelling of epiploic and parametrial fat in long-chain polyunsaturated omega 3 fatty acid deficiency (2007)

info:eu-repo/semantics/published
Status of the atomic fountain clock at the National Research Council of Canada (2016)

Despite the rapid advances in optical frequency standards, caesium fountain clocks retain a critical role as the most accurate primary frequency standards available. At the National Research Council Canada, we are working to develop a second generation caesium fountain clock. Work is currently underway to improve several systems of FCs1, such as the laser system and microwave local oscillator, which will be incorporated into its refurbished version, FCs2. In addition, we have added an optical pumping stage which has increased the detected atom number by over a factor of six. In collaboration with the National Physical Laboratory (NPL), we are planning on replacing the physics package of FCs1. We will report on several recent improvements to FCs1, along with our progress in the development of FCs2.