gebhart/patrepeval huggingface dataset:
Effect of Nb Addition on the Growth and Coarsening of Cu-particles in Ferritic Stainless Steel (2014)

The growth and coarsening of Cu-particles in 18%Cr–1.5%Cu ferritic stainless steels as a function of Nb content was investigated quantitatively. The samples were solution-treated at 1250°C and then isothermally aged at 700°C for up to 86400 s. Fine, spherical Cu-particles nucleated and grew during aging. The radius of the Cu particles increased in proportion to the one-third power of the aging time in all the stainless steels. The radius of the Cu particles in the Nb-added stainless steels was always smaller than that in the Nb-free stainless steel. The normalized standard deviation of the size distribution of the Cu particles increased and reached saturation at a certain value during aging. The increase in the standard deviation during aging was delayed by the addition of Nb. The volume fraction of Cu particles increased and reached saturation at a certain value during aging. The addition of niobium delayed the saturation of the volume fraction of the Cu particles. The slow growth of Cu particles in Nb-added stainless steels is thought to be owing to the slow diffusion of Nb atoms from the Cu particles.
[Sn<sub>6</sub>(PR)<sub>6</sub>], [Sn<sub>3</sub>(PR)<sub>2</sub>Cl<sub>2</sub>] und [Cu<sub>24</sub>(PR)<sub>12</sub>] R = Triorganosilyl): neue Zinn‐ und Kupfer‐Phosphandiyl‐Cluster (1997)

Neue Strukturmotive bei Haupt‐ und Nebengruppenmetall‐Phosphandiyl‐Clustern konnten mit dor Synthese der Titelverbindungen 1, 2 und 3 realisiert werden. Sie entstehen durch komplexe Brønsted‐Säure‐Base‐Reaktionen aus den entsprechenden primären Silylphosphanen und inerten Stannandiylderivaten bzw. [{CuO t Bu} 4 ]. Alle drei Verbindungen kommen ohne terminale Donorliganden an den Metallzentren aus. R = Triorganosilyl. magnified image
Bidirectional Recurrent Neural Networks as Generative Models - Reconstructing Gaps in Time Series (2015)

Bidirectional recurrent neural networks (RNN) are trained to predict both in the positive and negative time directions simultaneously. They have not been used commonly in unsupervised tasks, because a probabilistic interpretation of the model has been difficult. Recently, two different frameworks, GSN and NADE, provide a connection between reconstruction and probabilistic modeling, which makes the interpretation possible. As far as we know, neither GSN or NADE have been studied in the context of time series before. As an example of an unsupervised task, we study the problem of filling in gaps in high-dimensional time series with complex dynamics. Although unidirectional RNNs have recently been trained successfully to model such time series, inference in the negative time direction is non-trivial. We propose two probabilistic interpretations of bidirectional RNNs that can be used to reconstruct missing gaps efficiently. Our experiments on text data show that both proposed methods are much more accurate than unidirectional reconstructions, although a bit less accurate than a computationally complex bidirectional Bayesian inference on the unidirectional RNN. We also provide results on music data for which the Bayesian inference is computationally infeasible, demonstrating the scalability of the proposed methods.
Involvement of neuropeptide Y and its Y1 and Y5 receptors in maintaining self‐renewal and proliferation of human embryonic stem cells (2009)

Neuropeptide Y (NPY) and NPY receptors are widely expressed in various organs and cell types and have been shown to have pleiotropic functions. However, their presence or role in human embryonic stem cells (hESCs) remains unknown. We now show that undifferentiated hESCs primarily express NPY and its Y1 and Y5 receptors. Inhibition of NPY signalling using either the selective NPY Y1 or Y5 receptor antagonist reduces the maintenance of self-renewal and proliferation of undifferentiated hESCs. We also provide compelling evidence that exogenous NPY supports the long-term growth of undifferentiated hESCs in the absence of feeder cell factors using only knockout serum replacement media. Further, NPY facilitates the use of chemically defined medium made up of N2/B27 supplement and basic fibroblast growth factor (bFGF) for hESC feeder-free culture. Our results indicate that both Y1 and Y5 receptors appear to be involved in the NPY-mediated activation of AKT/protein kinase B and extracellular signal-regulated kinase 1/2 (ERK1/2) in hESCs. Notably, only Y1 receptor, but not Y5 receptor, is responsible for the NPY-induced activation of cAMP-response element binding (CREB) in hESCs. These results provide the first evidence that NPY and its Y1 and Y5 receptors have potential role in maintaining hESC self-renewal and pluripotency. We demonstrate the underlying importance of NPY signalling and its usefulness in the development of a defined and xeno-free culture condition for the large-scale propagation of undifferentiated hESCs.
An Experimental Study on Network-Listening Based Synchronization with Loop-Back Self-Interference Canceller (2016)

The overlaid cell structure, in which a large number of small cells are deployed in a macro-cell coverage area, is considered to be a promising approach in order to accommodate rapidly increasing mobile data traffic. In the overlaid cell structure, eICIC (enhanced Inter-Cell Interference Coordination) is an essential technique to avoid the interference between the macro cells and the small cells when co-channel deployment is used. Because eICIC conducts interference coordination in the time domain, accurate timing synchronization is required between the macro cells and the small cells. We have proposed a network-listening based synchronization method, which enables accurate synchronization even indoors without receiving GPS signal. In the proposed method, a small-cell eNB receives a macro-cell downlink synchronization signal and establishes synchronization with the macro-cell eNB. However, we need to update synchronization periodically and receive a macro-cell signal even while there is a loop-back interference signal from the small-cell eNB itself. In order to solve the problem, we have proposed a method to mute the transmission and avoid loop-back self-interference. Although this works well, it is an issue that the spectral efficiency is deteriorated by the signal stopping. In this paper, we propose a synchronization method that cancels loop-back self-interference without stopping the transmission of small-cell eNB and clarify the effect of the proposed method by computer simulations and laboratory experiments using the first-ever prototype system.
A deconvolution inverse-scattering imaging condition for RTM separated wavefield imaging (2018)

PreviousNext No AccessSEG Technical Program Expanded Abstracts 2018A deconvolution inverse-scattering imaging condition for RTM separated wavefield imagingAuthors: Sean CrawleyElena KlochikhinaDan WhitmoreSean CrawleyPGS, Elena KlochikhinaPGS, and Dan WhitmorePGShttps://doi.org/10.1190/segam2018-2996390.1 SectionsSupplemental MaterialAboutPDF/ePub ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InRedditEmail Abstract We describe a new imaging condition for reverse-time migration (RTM). Specifically, we extend the inverse scattering imaging condition (ISIC) to deconvolution in the temporal frequency domain, and apply it in an RTM version of Separated Wavefield Imaging (SWIM). Tests on both synthetic and field data show this method successfully removes low-wavenumber artifacts associated with backscattered energy and has similar strengths and challenges to deconvolution-based SWIM with one-way wave equation migration. Presentation Date: Wednesday, October 17, 2018 Start Time: 1:50:00 PM Location: 207A (Anaheim Convention Center) Presentation Type: Oral Keywords: deconvolution, reverse time migration, imagingPermalink: https://doi.org/10.1190/segam2018-2996390.1FiguresReferencesRelatedDetailsCited byBuilding adjoint operators for least-squares migration using the acoustic wave equationShaoping Lu, Han Wu, Xintong Dong, Tie Zhong, Lingyun Qiu, Xiang Li, Xiaofan Deng, and Rui Gao13 March 2023 | GEOPHYSICS, Vol. 88, No. 2Low-rank representation of omnidirectional subsurface extended image volumesMengmeng Yang, Marie Graff, Rajiv Kumar, and Felix J. Herrmann11 March 2021 | GEOPHYSICS, Vol. 86, No. 3Amplitude enhancement of RTM angle gathers with deconvolutionSean Crawley, Faqi Liu, Elena Klochikhina, Nizar Chemingui, and Dan Whitmore10 August 2019 SEG Technical Program Expanded Abstracts 2018ISSN (print):1052-3812 ISSN (online):1949-4645Copyright: 2018 Pages: 5520 publication data© 2018 Published in electronic format with permission by the Society of Exploration GeophysicistsPublisher:Society of Exploration Geophysicists HistoryPublished Online: 27 Aug 2018 CITATION INFORMATION Sean Crawley, Elena Klochikhina, and Dan Whitmore, (2018), "A deconvolution inverse-scattering imaging condition for RTM separated wavefield imaging," SEG Technical Program Expanded Abstracts : 4372-4376. https://doi.org/10.1190/segam2018-2996390.1 Plain-Language Summary Keywordsdeconvolutionreverse time migrationimagingPDF DownloadLoading ...
Non-Gaussian elliptic-flow fluctuations in PbPb collisions at <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" altimg="si1.gif" overflow="scroll"><mml:msqrt><mml:mrow><mml:msub><mml:mrow><mml:mi>s</mml:mi></mml:mrow><mml:mrow><mml:mtext>NN</mml:mtext></mml:mrow></mml:msub></mml:mrow></mml:msqrt><mml:mo>=</mml:mo><mml:mn>5.02</mml:mn><mml:mspace width="0.2em"/><mml:mtext>TeV</mml:mtext></mml:math> (2019)

Event-by-event fluctuations in the elliptic-flow coefficient v 2 are studied in PbPb collisions at
Mizoribine Suppresses the Progression of Experimental Peritoneal Fibrosis in a Rat Model (2009)

The administration of mizoribine prevented the progression of peritoneal fibrosis in this rat model. Mizoribine may represent a novel therapy for peritoneal sclerosis in patients undergoing long-term PD.
PlexProbes enhance qPCR multiplexing by discriminating multiple targets in each fluorescent channel (2022)

The probe technology described in this paper facilitates detection and discrimination of multiple targets in a single fluorescent channel during PCR. This provides a strategy for doubling the number of targets that can be analysed simultaneously on existing PCR instruments. These probes are referred to as PlexProbes and produce fluorescence that can be switched 'on' or 'off' in the presence of target by manipulating the temperature. During PCR, fluorescence can be measured at multiple temperatures allowing discrimination of specific targets at defined temperatures. In a single fluorescent channel, a model duplex assay allowed either real-time or endpoint detection of Chlamydia trachomatis (CT) at 52°C and end-point detection of Neisseria gonorrhoeae (GC) at 74°C. Using this model system, as few as 40 copies of each specific target could be detected as single infection or co-infection, regardless of the presence or absence of the other target. A PlexProbe prototype assay for sexually transmitted infections (PP-STI) which simultaneously enables detection and differentiation of six targets using only three fluorescent channels was then constructed and evaluated. The PP-STI assay detects GC (2 gene targets), CT, Mycoplasma genitalium (MG), Trichomonas vaginalis (TV) and an internal control (IC). To evaluate assay performance, a panel of archived clinical samples (n = 337) were analysed using PP-STI and results compared to those obtained with a commercially available diagnostic assay. The overall agreement between results obtained with the PP-STI assay and the reference test was greater than 99.5%. PlexProbes offer a method of detecting more targets from a single diagnostic test, empowering physicians to make evidence-based treatment decisions while conserving time, labour, sample volume and reagent costs.
In vitro CFD, MRI, STB Series (2019)

&lt;p&gt;&lt;strong&gt;These datasets were originally published as one large dataset, which is still available below. The same data are also available in sections (CFD, MRI, and STB) for easier downloading.&amp;nbsp;&lt;/strong&gt;&lt;/p&gt; &lt;div class="pub-content"&gt; &lt;p&gt;The data provided in this publication was used to evaluate parameters including wall shear stress (WSS), oscillatory shear index (OSI), and relative residence times (RRT) across multiple modalities and two patient-specific aneurysm geometries. Specifically, the assumptions and limitations of each modality coupled with the varying and often low spatial resolution and their subsequent effect on the hemodynamic metrics was explored. The results of this study demonstrated that non-dimensional parameters, such as OSI, were more robust to varying modalities and spatial resolutions and thus may provide more robust risk or growth and rupture assessments. These results demonstrate a need for further investigation and development of non-dimensional parameters and correlation of such parameters to risk of aneurysm.&lt;/p&gt; &lt;p&gt;Additionally, the pulsatile particle velocimetry results provided here can be used as robust validation test cases for computational fluid dynamics (CFD) solvers.&lt;/p&gt; &lt;p&gt;These data files were created using Matlab 2016.&lt;/p&gt; &lt;/div&gt; &lt;p&gt;&amp;nbsp;&lt;/p&gt;
Data from A Novel, Fully Human Anti–fucosyl-GM1 Antibody Demonstrates Potent &lt;i&gt;In Vitro&lt;/i&gt; and &lt;i&gt;In Vivo&lt;/i&gt; Antitumor Activity in Preclinical Models of Small Cell Lung Cancer (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The ganglioside fucosyl-GM1 (FucGM1) is a tumor-associated antigen expressed in a large percentage of human small cell lung cancer (SCLC) tumors, but absent in most normal adult tissues, making it a promising target in immuno-oncology. This study was undertaken to evaluate the preclinical efficacy of BMS-986012, a novel, nonfucosylated, fully human IgG1 antibody that binds specifically to FucGM1.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; The antitumor activity of BMS-986012 was evaluated in &lt;i&gt;in vitro&lt;/i&gt; assays using SCLC cells and in mouse xenograft and syngeneic tumor models, with and without chemotherapeutic agents and checkpoint inhibitors.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; BMS-986012 showed a high binding affinity for FcγRIIIa (CD16), which resulted in enhanced antibody-dependent cellular cytotoxicity (ADCC) against FucGM1-expressing tumor cell lines. BMS-986012–mediated tumor cell killing was also observed in complement-dependent cytotoxicity (CDC) and antibody-dependent cellular phagocytosis (ADCP) assays. In several mouse SCLC models, BMS-986012 demonstrated efficacy and was well tolerated. In the DMS79 xenograft model, tumor regression was achieved with BMS-986012 doses of 0.3 mg/kg and greater; antitumor activity was enhanced when BMS-986012 was combined with standard-of-care cisplatin or etoposide. In a syngeneic model, tumors derived from a genetically engineered model of SCLC were treated with BMS-986012 or anti-FucGM1 with a mouse IgG2a Fc and their responses evaluated; when BMS-986012 was combined with anti–PD-1 or anti-CD137 antibody, therapeutic responses significantly improved.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Single-agent BMS-986012 demonstrated robust antitumor activity, with the addition of chemotherapeutic or immunomodulatory agents further inhibiting SCLC growth in the same models. These preclinical data supported evaluation of BMS-986012 in a phase I clinical trial of patients with relapsed, refractory SCLC. &lt;i&gt;Clin Cancer Res; 24(20); 5178–89. ©2018 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Cisco Secure Intrusion Detection Systems (2001)

From the Publisher:
Implement network surveillance system for 24-hour security with the official CSIDS Coursebook.

Cisco Secure Intrusion Detection Systems provides a clear explanation of why network security is crucial in today's converged networking environment, how the Cisco Secure Intrusion Detection System (CSIDS) improves the security on a network, and how to install and configure CSIDS. The Cisco Secure Intrusion Detection System is a real-time, network-based IDS designed to detect, report, and terminate unauthorized activity throughout a network. The industry's first and now the market-leading IDS, CSIDS is the dynamic security component of Cisco's end-to-end security product line.

The only book that concentrates solely on implementation of Cisco Secure Intrusion Detection Systems.Full of configuration techniques and security management details.Based on officially developed course materials from Cisco Systems.Recommended training materials for the Cisco security specialization certification
&lt;I&gt;In-Vitro&lt;/I&gt; and &lt;I&gt;In-Vivo&lt;/I&gt; Studies on Novel Chitosan-g-Pluronic F-127 Copolymer Based Nanocarrier of Amphotericin B for Improved Antifungal Activity (2014)

The present communication is focusing on development of safe nanotemplates for sustained delivery of amphotericin B (AmB). We synthesized a block copolymer based on chitosan and Pluronic F-127 (PEO–b–PPO–b–PEO). Selection of Pluronic F-127 was based upon the criteria’s that it has smaller size, higher aqueous solubility and stability whereas; chitosan is a natural, non toxic, biodegradable polysaccharide. AmB loaded micelles were prepared by direct dissolution and pH dependent method. Various formulations were prepared using different drug polymer ratio to optimize the size, size distribution, zeta potential and drug loading efficiency. Optimized formulation was characterized for drug release pattern, haemolytic potential, in-vitro anti fungal activity and, in-vivo toxicity and compared with the marketed formulation (fungizone). The particle size and zeta potential of the micelles were found in the range between 90.2±10.21 to 148.7±21.03 and -16.3±4.24 to +31.1±6.10, respectively. The drug loading was found between 16.7±4.76% to 33.3±2.67% for all the developed formulations. Developed formulations showed negligible hemolytic toxicity with comparison to marketed formulation. In vitro antifungal studies demonstrated that micelles were more active than fungizone against C. albicans and A. fumigatus. Furthermore, AmB showed less nephrotoxicity when encapsulated in micelles in comparison to marketed formulation. These results together revealed that the developed formulation would be a safe and efficacious alternative to current marketed formulation to ameliorate the treatment of fungal infection.
Novel Pliable Electrodes for Flexible Electrochemical Energy Storage Devices: Recent Progress and Challenges (2016)

With wearable electronics rapidly coming into fashion, research into flexible energy storage devices and in particular, pliable electrodes, is attracting a lot of attention. Pliable electrodes are usually fabricated by intercalating an active material in a flexible matrix with superior mechano‐electrical properties, and can be grouped either as substrate‐supported or free‐standing. Depending on their mode of deformation the electrodes can be labeled as bendable, compressible or stretchable. Recent progress and challenges in the design and fabrication of pliable electrodes for constructing flexible lithium ion batteries and flexible supercapacitors are highlighted. 2 pliable core‐shell structure electrodes fabricated from: a) carbon nanotube sponge embedded with MoS 2 nanoparticles and b) electrospun polyethylene terephthalate fibers impregnated with graphene nanoplatelets are also presented.
Collaboration and Interventions on Urban Environment Mapping with Graph-based SLAM Algorithm (2020)

The article describes the implementation of a collaborative approach for localization and mapping of large urban environments. This approach foresees the presence of multiple human operators, endowed with wearable sensors, whose outputs are processed in real-time in order to estimate human odometry. A Graph-based CLAM approach, generating a global map, is then applied: in order to improve the optimization phase of the algorithm, deterministic and probabilistic intervention approaches are proposed. More in detail, the loop closure procedure has been improved according to human sensing and the observations of external sensors. Experimental tests have been carried out in the historical center of Genova, proving that the proposed method overcomes classical multi-operator SLAM approaches.
Early Metabolic Programming of Puberty Onset: Impact of Changes in Postnatal Feeding and Rearing Conditions on the Timing of Puberty and Development of the Hypothalamic Kisspeptin System (2011)

Kiss1 neurons have recently emerged as a putative conduit for the metabolic gating of reproduction, with leptin being a regulator of hypothalamic Kiss1 expression. Early perturbations of the nutritional status are known to predispose to different metabolic disorders later in life and to alter the timing of puberty; however, the potential underlying mechanisms remain poorly defined. Here we report how changes in the pattern of postnatal feeding affect the onset of puberty and evaluate key hormonal and neuropeptide [Kiss1/kisspeptin (Kp)] alterations linked to these early nutritional manipulations. Female rats were raised in litters of different sizes: small (four pups per dam: overfeeding), normal (12 pups per dam), and large litters (20 pups per litter: underfeeding). Postnatal overfeeding resulted in persistently increased body weight and earlier age of vaginal opening, as an external sign of puberty, together with higher levels of leptin and hypothalamic Kiss1 mRNA. Conversely, postnatal underfeeding caused a persistent reduction in body weight, lower ovarian and uterus weights, and delayed vaginal opening, changes that were paralleled by a decrease in leptin and Kiss1 mRNA levels. Kisspeptin-52 immunoreactivity (Kp-IR) in the hypothalamus displayed similar patterns, with lower numbers of Kp-IR neurons in the arcuate nucleus of postnatally underfed animals, and a trend for increased Kp-positive fibers in the periventricular area of early overfed rats. Yet, gonadotropin responses to Kp at puberty were similar in all groups, except for enhanced responsiveness to low doses of Kp-10 in postnatally underfed rats. In conclusion, our data document that the timing of puberty is sensitive to both overfeeding and subnutrition during early (postnatal) periods and suggest that alterations in hypothalamic expression of Kiss1/kisspeptin may underlie at least part of such programming phenomenon.
Mouse–human co-clinical trials demonstrate superior anti-tumour effects of buparlisib (BKM120) and cetuximab combination in squamous cell carcinoma of head and neck (2020)

NCT01527877.
Change in the Redox State of Glutathione Regulates Differentiation of Tracheary Elements in Zinnia Cells and Arabidopsis Roots (2005)

Exogenously applied GSH and GSSG can control the in vitro differentiation of mesophyll cells to tracheary elements (TEs) in Zinnia elegans, and de novo GSH synthesis is essential for the early differentiation. The purpose of the present study is to address how GSH and GSSG control TE differentiation. GSSG transiently accumulated during the in vitro TE differentiation and exogenously applied GSSG down-regulated transcript levels of GSSG reductase (GR), an enzyme maintaining glutathione in a reduced redox state, while there were no significant changes in transcript levels of enzymes involved in GSH synthesis. Transgenic Arabidopsis overexpressing the GR gene showed delayed TE formation in the root, which was attributed to the suppression of cell division. Exogenously applied GSH had an effect similar to overexpression of the GR gene. These findings suggest that reduced states of glutathione suppress TE differentiation. In wild-type Arabidopsis, TE formation was promoted by application of GSSG at an appropriate concentration, but was suppressed at higher concentrations. A T-DNA-inserted knockout mutant of cytosolic GR exhibited delayed TE formation; this phenotype was little affected by GSSG application. Taken together, the process of the redox changes in glutathione is considered to be controlled via GR activity for TE differentiation.