gebhart/patrepeval huggingface dataset:
Intravenous vortioxetine to accelerate onset of effect in major depressive disorder: a 7-day randomized, double-blind, placebo-controlled exploratory study (2020)

This 7-day randomized, double-blind, placebo-controlled fixed-dose study (NCT03766867) explored the potential for accelerating the onset of antidepressant efficacy of single-dose intravenous (IV) vortioxetine at oral vortioxetine treatment initiation. Patients (ages 18-65 years) hospitalized per standard-of-care with major depressive disorder, who were currently treated with a selective serotonin reuptake inhibitor or serotonin-norepinephrine reuptake inhibitor for a major depressive episode [Montgomery-Åsberg Depression Rating Scale (MADRS) total score ≥ 30], received one dose of single-blind IV placebo (1-day placebo lead-in period) before being randomly switched to either single-dose IV vortioxetine 25 mg plus daily oral vortioxetine 10 mg (n = 39), or IV placebo plus daily oral placebo (n = 41). In the placebo lead-in period, patients improved slightly by 0.6 MADRS-6 point; however, at day 1 after randomization, both treatment groups had improved by approximately 3 MADRS-6 points (mean difference = -0.8; P = 0.263), the study thus not meeting its primary endpoint. Similar results were seen for other outcomes except a numerically larger improvement in anxiety symptoms with vortioxetine vs placebo. Pharmacokinetic data confirmed that IV vortioxetine facilitated reaching steady-state plasma concentration within 24 h. IV plus oral vortioxetine was well tolerated, with low levels of nausea as the most common adverse event.
Gas chromatography utilizing SAW sensors (2002)

The performance of a high-speed (10-15-s) gas chromatography system for the detection of illicit materials is described. The system is based on an isothermal capillary column gas chromatograph (GC) and a 500-MHz surface acoustic wave (SAW) crystal decoder. The SAW sensor operates as an integrating GC detector and is able to continue operating for extended periods without replacement by using periodic in situ cleaning. Specificity to materials of interest is enhanced by controlling the sorption/desorption characteristics of the SAW crystal surface. The system is capable of operating over a wide range of vapor concentrations extending from femtograms to many nanograms without overloading.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Oestrogen-driven changes in the bovine uterus are associated with activation of the unfolded protein response (2014)

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)
Millimeter-Wave Antenna Array Diagnosis with Partial Channel State\n Information (2020)

Large antenna arrays enable directional precoding for Millimeter-Wave\n(mmWave) systems and provide sufficient link budget to combat the high\npath-loss at these frequencies. Due to atmospheric conditions and hardware\nmalfunction, outdoor mmWave antenna arrays are prone to blockages or complete\nfailures. This results in a modified array geometry, distorted far-field\nradiation pattern, and system performance degradation. Recent remote array\ndiagnostic techniques have emerged as an effective way to detect defective\nantenna elements in an array with few diagnostic measurements. These\ntechniques, however, require full and perfect channel state information (CSI),\nwhich can be challenging to acquire in the presence of antenna faults. This\npaper proposes a new remote array diagnosis technique that relaxes the need for\nfull CSI and only requires knowledge of the incident angle-of-arrivals, i.e.\npartial channel knowledge. Numerical results demonstrate the effectiveness of\nthe proposed technique and show that fault detection can be obtained with\ncomparable number of diagnostic measurements required by diagnostic techniques\nbased on full channel knowledge. In presence of channel estimation errors, the\nproposed technique is shown to out-perform recently proposed array diagnostic\ntechniques.\n
Direct Measurement of Skin Friction in Complex Fluid Flows (1997)

This paper describes methods for the direct measurement of skin friction in fluid flows under a very wide variety of conditions. The challenges involved in different flow situations are highlighted, and representative instrument designs and measurement results are presented. The test conditions considered span the range from incompressible to hypersonic speeds; ambient to very high temperature including combusting flows; smooth, rough, and porous surfaces with and without injection and test times from 10-6 to essentially continuous runs. Both 2D and 3D flows are discussed. Accuracies of +/- 3-5% are presently attainable in the simplest cases, while +/- 10-15% is more typical for complex, 3D, high-speed flows at high temperatures. The final topic discussed is simultaneous measurements of skin friction and heat flux with the possible further additions of surface pressure and temperature.
Corticosteroids Enhance the Capacity of Macrophages to Induce Th2 Cytokine Synthesis in CD4+ Lymphocytes by Inhibiting IL-12 Production (1998)

We investigated the effects of corticosteroids on IL-12 production by mouse splenic adherent cells and the subsequent capacity of these cells to induce cytokine production by CD4+ T cells. To distinguish the effects of corticosteroids on APCs from those on T cells, only the APCs and not the T cells were exposed to corticosteroids. Treatment of splenic adherent cells with dexamethasone greatly inhibited production of IL-12, a cytokine known to enhance IFN-gamma synthesis and decrease IL-4 synthesis by CD4+ T cells. The reduction in IL-12 production by corticosteroid-treated macrophages decreased their ability to induce IFN-gamma and increased their ability to induce IL-4 synthesis in Ag-primed CD4+ T cells. Splenic adherent cells from mice treated in vivo with dexamethasone also displayed a reduced capacity to produce IL-12. These results help to resolve previous conflicting observations regarding the effects of corticosteroids on cytokine production by T cells, and indicate that while corticosteroids may directly inhibit Th1 and Th2 cytokine production in T cells, corticosteroids, by reducing IL-12 production in APCs, have the potential to indirectly enhance Th2 cytokine synthesis. Therefore, treatment of diseases such as allergy with chronic corticosteroids may indirectly exacerbate the course of the disease, which is caused primarily by the overproduction of Th2 cytokines in allergen-specific CD4+ T cells.
Critical Swimming Speeds of Yellow Perch <i>Perca Flavescens</i>: Comparison of Populations from a Naturally Acidic Lake and a Circumneutral Lake in Acid and Neutral Water (1989)

ABSTRACT The objectives of this study were to determine if environmental acidity reduces swimming performance in the acid-tolerant yellow perch (Perca flavescens) and to use swimming performance as an indicator of fitness in testing whether fish from naturally acidic environments perform better in acidic water. Perch from a naturally acidic lake (pH 4·4) or a nearby circumneutral lake were swum after either 5–7 months of laboratory acclimation to simulated soft, natural waters or after more than 2 years of acclimation to hard, circumneutral water. The performance test was a critical swimming speed (Ucrit) determination, with 5cms-1 velocity increments at 30 min intervals. Low environmental pH (4·0) produced significant decreases in average swimming performance in each of three experimental series. Acid decreased performance in most but not all fish. The two perch populations had similar mean Ucrit values when swimming in acid water. Pre-acclimation to hard water significantly increased swimming performance. Gravid females acclimated to acid water had very low critical swimming speeds in acid water, whereas Ucrit changed little in acid water when oogenesis occurred in neutral water.
Residual internal stress optimization for EPON 828/DEA thermoset resin using fiber Bragg grating sensors. (2016)

Abstract not provided.
Novel Electrochemical Reductive Amination of 4‘‘-Oxo-5-<i>O</i>-(<i>tert</i>-butyl- dimethylsilyl)avermectin B<sub>1</sub> (1997)

ADVERTISEMENT RETURN TO ISSUEPREVNoteNovel Electrochemical Reductive Amination of 4''-Oxo-5-O-(tert-butyl- dimethylsilyl)avermectin B1Raymond J. Cvetovich, Joseph S. Amato, Lisa DiMichele, Leonard Weinstock, and George HazenView Author Information Department of Process Research, Merck Research Laboratories, Division of Merck & Company, Inc., P.O. Box 2000, Rahway, New Jersey 07065 Cite this: J. Org. Chem. 1997, 62, 19, 6697–6698Publication Date (Web):September 19, 1997Publication History Received15 April 1997Published online19 September 1997Published inissue 1 September 1997https://pubs.acs.org/doi/10.1021/jo970676lhttps://doi.org/10.1021/jo970676lbrief-reportACS PublicationsCopyright © 1997 American Chemical SocietyRequest reuse permissionsArticle Views527Altmetric-Citations2LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information SUBJECTS:Amines,Electrochemical reduction,Electrodes,Ketones,Organic reactions Get e-Alerts
Dynamics of Mismatch Correction in the Hippocampal Ensemble Code for Space: Interaction between Path Integration and Environmental Cues (1996)

Populations of hippocampal neurons were recorded simultaneously in rats shuttling on a track between a fixed reward site at one end and a movable reward site, mounted in a sliding box, at the opposite end. While the rat ran toward the fixed site, the box was moved. The rat returned to the box in its new position. On the initial part of all journeys, cells fired at fixed distances from the origin, whereas on the final part, cells fired at fixed distances from the destination. Thus, on outward journeys from the box, with the box behind the rat, the position representation must have been updated by path integration. Farther along the journey, the place field map became aligned on the basis of external stimuli. The spatial representation was quantified in terms of population vectors. During shortened journeys, the vector shifted from an alignment with the origin to an alignment with the destination. The dynamics depended on the degree of mismatch with respect to the full-length journey. For small mismatches, the vector moved smoothly through intervening coordinates until the mismatch was corrected. For large mismatches, it jumped abruptly to the new coordinate. Thus, when mismatches occur, path integration and external cues interact competitively to control place-cell firing. When the same box was used in a different environment, it controlled the alignment of a different set of place cells. These data suggest that although map alignment can be controlled by landmarks, hippocampal neurons do not explicitly represent objects or events.
Drought Avoidance Assessment for Summer Annual Crops Using Long‐Term Weather Data (2003)

Seasonal rainfall is a key factor determining yield of nonirrigated, summer crops. In temperate regions, however, systematic analyses of long‐term weather data have not been used for directing breeding programs or for crop management options. We evaluated long‐term weather data (36–98 yr) for 16 sites in four geographical regions in the USA to assess the potential for drought avoidance. For each day of year when the probability ( P ) of having a minimum temperature &lt;0°C was less than 0.05, water deficit was estimated as the difference between the 7‐d running sums of rainfall and potential evaporation. For comparative purposes across locations, a 7‐d water deficit &gt;50 mm was defined as a drought. For the Midsouth, there were approximately 62 d at both the beginning and end of the growing season with P ≤ 0.20 of drought. In the Southeast, there were approximately 48 d and 121 d at the beginning and end of the growing season, respectively, with P ≤ 0.20 of drought. For the Midwest, P of drought was ≤0.20 throughout the growing season for three of the four sites, and it was concluded that a 50‐mm water deficit was not likely to be a production constraint on the deep soils of the Midwest. For the Northern Great Plains, P of drought was &gt;0.20 for more than half of the region's growing season. This meteorological approach for assessing drought may provide insights for drought avoidance in breeding and crop management.
FinFET RF receiver building blocks operating above 10 GHz (2009)

A FinFET VCO and a differential LNA operating at 17 GHz are presented. The LNA contains on-chip input and output baluns, the input balun for the conversion of the single-ended antenna signal, and it achieves a gain of 9.4 dB and a noise figure of 6.6 dB when the output balun is deembedded; the power consumption is 26 mW from a 1 V supply. The VCO oscillates between 15.3 - 17.1 GHz and reaches a phase noise of -94 dBc/Hz at 1 MHz frequency offset with a power consumption of 7.5 mW. Device characterization data for circuit assessment and performance extrapolation is additionally presented.
Appetite of an epiphyte: Quantitative monitoring of bacterial sugar consumption in the phyllosphere (2001)

We report here the construction, characterization, and application of a bacterial bioreporter for fructose and sucrose that was designed to monitor the availability of these sugars to microbial colonizers of the phyllosphere. Plasmid pP(fruB)-gfp[AAV] carries the Escherichia coli fruB promoter upstream from the gfp[AAV] allele that codes for an unstable variant of green fluorescent protein (GFP). In Erwinia herbicola, this plasmid brings about the accumulation of GFP fluorescence in response to both fructose and sucrose. Cells of E. herbicola (pP(fruB)-gfp[AAV]) were sprayed onto bean plants, recovered from leaves at various time intervals after inoculation, and analyzed individually for GFP content by quantitative analysis of digital microscope images. We observed a positive correlation between single-cell GFP accumulation and ribosomal content as determined by fluorescence in situ hybridization, indicating that foliar growth of E. herbicola occurred at the expense of fructose and/or sucrose. One hour after inoculation, nearly all bioreporter cells appeared to be actively engaged in fructose consumption. This fraction dropped to approximately 11% after 7 h and to approximately 1% a day after inoculation. This pattern suggests a highly heterogeneous availability of fructose to individual E. herbicola cells as they colonize the phyllosphere. We estimated that individual cells were exposed to local initial fructose abundances ranging from less than 0.15 pg fructose to more than 4.6 pg.
New autoinjector technology for the delivery of subcutaneous methotrexate in the treatment of rheumatoid arthritis (2014)

Methotrexate (MTX) is the cornerstone of treatment for rheumatoid arthritis (RA), and is widely used both as first-line therapy and as an important component of long-term therapy. Although subcutaneous MTX is typically delivered orally, parenteral administration offers benefits with respect to tolerability and systemic exposure, and may be an underutilized treatment option. The RA patient population presents specific challenges for safe and accurate administration of parenteral therapies, because of common symptoms of joint pain and limited manual dexterity. These challenges may contribute to the low incidence of parenteral MTX administration. A novel MTX autoinjector (MTXAI) was recently introduced, which is designed to facilitate subcutaneous MTX self-administration among patients with RA. Here we review the development and utility of the MTXAI in the treatment of RA, and discuss how this technology may facilitate the use of subcutaneous MTX.
The syntheses, structures, and electronic and resonance-Raman spectroscopy of halogen-bridged platinum(II,IV) chain complexes involving equatorially co-ordinated terdentate amines: X- ray crystal structure of [Pt II (Me-dien)I][Pt IV (Me-dien)I3]I2, and spectroscopy of [Pt II (dien)(NO2)][Pt IV (dien)(NO2)Br2]Br2 (1986)

Three chain platinum(II,IV) complexes of the type [PtL3X][PtL3XY2]Z2(L3= terdentate ligand, X = halogen or NO2–, Y = halogen, Z = monoanion) have been synthesised. Two of these have been studied in detail, one by X-ray and the other by spectroscopic methods. The first, [Pt(Me-dien)I]-[Pt(Me-dien)I3]I2(Me-dien =N-methyldiethylenetriamine), has been found to crystallize in the monoclinic space group P21/n, with a= 19.830(8), b= 12.220(5), c= 11.079(6)Å, β= 96.49(4)°, and Z= 4. Refinement on 1 543 independent reflections led to a final R value of 0.043. The Pt–I chain distances are 2.679(3) and 2.691(3)Å(PtIV) and 3.443(3) and 3.560(3)Å(PtII) the chain deviating substantially at iodine and platinum(II) from linearity [PtIV–I–PtII= 150.5(1) and 149.1(1)°; I–PtII-I = 162.8(1)°], but not at platinum(IV)[I–PtIV–I = 179.4(1)°]. The second complex studied in detail, [Pt(dien)(NO2)][Pt(dien)(NO2) Br2] Br2(dien = diethylenetriamine), was found to yield a very intense resonance-Raman spectrum, the principal observed progression being v1ν1, where ν1(181.5 cm–1) is the symmetric stretching mode of the chain, νsym(Br–PtIV–Br). Analysis of these data yields ω1 and x11 values of 181.9 and –0.2 cm–1, respectively. Further, much weaker, progressions of the sorts v1ν1+νsym(NO2)(to v1= 5) and v1ν1+δsym(NO2)(to v1= 4) were also detected. The results add substantially to the few previously known data on halogenbridged mixed-valence chain complexes of platinum in which each unit carries a single positive charge.
Synthesis of [(tmeda)LiCH<sub>2</sub>PMe<sub>2</sub>Li(tmeda)CH<sub>2</sub>PMe<sub>2</sub>](tmeda = tetramethyl-ethylenediamine) and of a binuclear zirconocene phosphine functionalized ketene complex, [(η-C<sub>5</sub>H<sub>5</sub>)<sub>2</sub>ClZr(PMe<sub>2</sub>CHCO)ZrCl(η-C<sub>5</sub>H<sub>5</sub>)<sub>2</sub>](both structurally characterized), the latter via carbonylation of ‘[(η-C<sub>5</sub>H<sub>5</sub>)<sub>2</sub>ZrCl(CH<sub>2</sub>PMe<sub>2</sub>)]’ (1984)

Reaction of [(tmeda)L[graphic omitted]Me2], (1), or (tmeda tetramethylethylenediamine) with [(η-C5H5)2ZrCl2] in tetrahydrofuran at –78 °C yields [(η-C5H5)2Zr(CH2PMe2)n, Cl2 –n]n= 1, (2), n= 2, (3); carbonylation of (2) affords exclusively a novel binuclear ketene complex, [(η-C5H5)2ClZ[graphic omitted]Cl(η-C5H5)2], (4), which in the crystal form possesses a Zr–P linkage [2.724(5)Å].
2-[(Phenylthio)methyl]pyridine derivatives: new antiinflammatory agents (1983)

2-[(Phenylthio)methyl]pyridine derivatives inhibited the dermal reverse passive Arthus reaction (RPAR) in the rat. In the same model, indomethacin was inactive, and hydrocortisone was active. Compounds Ia-d also significantly reduced exudate volume and white blood cell accumulation in the pleural RPAR. This pattern of activity was similar to that of hydrocortisone and different from that of indomethacin.
Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop (2020)

The heat shock protein (Hsp) Hsp90 is one of the most abundant proteins in the cell. It controls the functional turnover of proteins being involved in protein folding, refolding, transport as well as protein degradation. Co-chaperones influence Hsp90's activity in different ways, among which the Hsp organizing protein (Hop) was found to inhibit its ATP hydrolysis upon binding. Despite the availability of a number of studies investigating the Hsp90:Hop complex, several aspects of the Hsp90:Hop interaction have remained unresolved. Here, we employed a combinatory approach comprising native polyacrylamide gel electrophoresis, isothermal titration calorimetry, multiangle light scattering, isothermal titration calorimetry, small-angle X-ray scattering, dynamic light scattering, and nuclear magnetic resonance, spectroscopy to obtain a comprehensive picture about the human Hsp90β:Hop association in solution. Our data show that only one Hop molecule binds the Hsp90β dimer, Hop can interact with the open and closed state of Hsp90β, and Hop's TPR2A-2B domains determine the affinity for Hsp90's C-terminal and middle domain, whereby the interaction with the C-terminal domain of Hsp90β is sufficient to induce an allosteric conformational change between the two Hsp90β monomers in the Hsp90<sub>2</sub> :Hop<sub>1</sub> complex. Together, this study highlights the important role of the co-chaperone Hop in reorganizing Hsp90 for efficient client loading.
Experimental Study on the Influence of Urban Water Body on Thermal Environment at Outdoor Scale Model (2016)

Urban Heat Island (UHI) has become a common urban problem that may lead to human health issues and increase in air-conditioning energy demand due to increase of air temperature. In order to reduce the UHI effect and improve the outdoor thermal environment is necessary to assess the effect of various measures. Water bodies' ability to regulate the microclimate arguably has the potential to mitigate the effect. Water bodies commonly found in urban area are usually described as a permanent or temporary collection of water in form of small stationary water or pond. These water bodies contribute to altering the surrounding thermal environment due to its cooling effect, either by evaporation or transfer of heat between air and the water. In real urban condition, however, the heterogeneity makes it difficult to assess the cooling benefits and to isolate the effects of individual parameter (such as shape, surface area, wind condition or solar radiation) under the complex physic process involved in the urban meteorology. As an alternative method, an outdoor measurement on a physically reduced scale model was conducted in summer. The outdoor-scaled model consists of an array of 1.5m concrete cubes and able to recreate thermal pattern similar to the actual urban condition. A typical of commonly found water bodies in urban areas, pond, was installed in the scale model to have a better understanding on potential benefits of water bodies in urban area. In this paper, the author present initial findings on the characteristic of surrounding microclimate and its influential factors, particularly ambient air temperature near urban water body derived from the proposed approach. The experiment result shows interesting patterns, which generally shows cooling effect during the day and even though is limited it also happen during the night. Moreover, the present of more solar radiation and low wind conditions are found further enhance the cooling effect.
Cardiovascular Molecular Imaging (2007)

The goal of this review is to highlight how molecular imaging will impact the management and improved understanding of the major cardiovascular diseases that have substantial clinical impact and research interest. These topics include atherosclerosis, myocardial ischemia, myocardial viability, heart failure, gene therapy, and stem cell transplantation. Traditional methods of evaluation for these diseases will be presented first, followed by methods that incorporate conventional and molecular imaging approaches.