gebhart/patrepeval huggingface dataset:
Concideration of impedance matching on power conversion circuit for magnetic energy harvesting (2015)

In recent years, energy harvesting is an attractive research for worldwide engineers. An environmental magnetic field around power lines and electric appliances could be regarded as a reusable energy source. This paper considers the impedance matching on power conversion circuit for magnetic energy circuit. The Cockcroft-Walton circuit consisting of ideal diodes are used for this considerations. Based on the maximum power transfer theorem, the optimum load is expressed by the two parameters: input resistance and number of steps in the Cockcroft-Walton circuit. From both the analysis and experimental results, the estimated output voltage and power are confirmed.
Pseudomyotonia in Romagnola cattle caused by novel ATP2A1mutations (2012)

Clinical, biochemical and DNA analyses confirmed the initial hypothesis. We provide functional and genetic evidence that one novel and one previously described ATP2A1 mutation lead to a reduced SERCA1 activity in skeletal muscles and pseudomyotonia in affected Romagnola cattle. Selection against these mutations can now be used to eliminate the mutant alleles from the Romagnola breed.
Human Metapneumovirus Glycoprotein G Disrupts Mitochondrial Signaling in Airway Epithelial Cells (2013)

Human metapneumovirus (hMPV) is a recently identified RNA virus belonging to the Paramyxoviridae family. It is a common cause of respiratory tract infections in children, adults, and immunocompromised patients, for which no specific treatment or vaccine is available. Recent investigations in our lab identified hMPV glycoprotein G as an important virulence factor, as a recombinant virus lacking the G protein (rhMPV-ΔG) exhibited enhanced production of important immune and antiviral mediators, such as cytokines, chemokines and type I interferon (IFN) in airway epithelial cells, and expression of G protein alone inhibits cellular signaling dependent on retinoic induced gene (RIG)-I, a RNA helicase with a fundamental role in initiating hMPV-induced cellular responses. In this study, we have further investigated the mechanism underlying the inhibitory role of hMPV G protein on RIG-I-dependent signaling. We found that the interaction of hMPV G with RIG-I occurs primarily through the CARD domains of RIG-I N-terminus, preventing RIG-I association with the adaptor protein MAVS (mitochondrial antiviral signaling protein), recruitment of RIG-I to mitochondria, as well as the interaction between mitochondria and mitochondria-associated membrane (MAM) component of the endoplasmic reticulum (ER), which contains STINGS, an important part of the viral-induced RIG-I/MAVS signaling pathway, leading in the end to the inhibition of cytokine, chemokine and type I IFN expression. Mutagenesis analysis showed that hMPV G protein cytoplasmic domain played a major role in the observed inhibitory activity, and recombinant viruses expressing a G protein with amino acid substitution in position 2 and 3 recapitulated most of the phenotype observed with rhMPV-ΔG mutant upon infection of airway epithelial cells.
BT-Nurse: computer generation of natural language shift summaries from complex heterogeneous medical data (2011)

The BT-Nurse system uses data-to-text technology to automatically generate a natural language nursing shift summary in a neonatal intensive care unit (NICU). The summary is solely based on data held in an electronic patient record system, no additional data-entry is required. BT-Nurse was tested for two months in the Royal Infirmary of Edinburgh NICU. Nurses were asked to rate the understandability, accuracy, and helpfulness of the computer-generated summaries; they were also asked for free-text comments about the summaries. The nurses found the majority of the summaries to be understandable, accurate, and helpful (p<0.001 for all measures). However, nurses also pointed out many deficiencies, especially with regard to extra content they wanted to see in the computer-generated summaries. In conclusion, natural language NICU shift summaries can be automatically generated from an electronic patient record, but our proof-of-concept software needs considerable additional development work before it can be deployed.
Relationship between Body Composition and Reproduction in Heifers (2002)

Carcass and reproductive data including scan weight, ribeye area, rump fat, 12-13th rib fat and percentage intramuscular fat and reproductive tract scores (RTS) at 344 days were collected on 180 1998-born and 70 1999-born Angus heifers to determine the relationship between these traits. 1998-born heifers with higher RTS tended to be heavier and have more rump fat at 405 days (P &lt; .05). Heavier heifers and heifers with more rump fat had higher RTS when adjusted to 395 days (P &lt; .05). 1999-born heifers showed a similar pattern, with heavier heifers having higher RTS (P &lt; .05). Rump fat was not as significant for 1999-born heifers compared with 1998-born heifers. Heavier heifers with more rump fat are more likely to have more mature reproductive tracts at breeding.
General Framework for Binary Classification on Top Samples (2020)

Many binary classification problems minimize misclassification above (or below) a threshold. We show that instances of ranking problems, accuracy at the top or hypothesis testing may be written in this form. We propose a general framework to handle these classes of problems and show which known methods (both known and newly proposed) fall into this framework. We provide a theoretical analysis of this framework and mention selected possible pitfalls the methods may encounter. We suggest several numerical improvements including the implicit derivative and stochastic gradient descent. We provide an extensive numerical study. Based both on the theoretical properties and numerical experiments, we conclude the paper by suggesting which method should be used in which situation.
On optimal structure and geometry of high-speed integrated photodiodes in a standard cmos technology (2004)

Analyses of the influence of different geometries (layouts) and structures of high-speed CMOS photodiodes on their intrinsic (physical) and electrical bandwidths are presented. Three photodiode structures are studied: nwell/p-substrate, p+/nwell/p-substrate and p+/nwell. According to the author's knowledge, this is a first time that the influence of various structures and geometries (layouts) of CMOS photodiodes on their bandwidth is analytically analysed.
Oxygen barrier properties of polypropylene/polyamide 6 blends (1995)

Abstract Effects of composition, compatibilization, and blending procedure on oxygen barrier properties of injection‐molded polypropylene/polyamide 6 blends were investigated. The main attention was paid to the relationships between oxygen permeability, mechanical properties, and blend morphology. The effect of the polypropylene/polyamide 6 ratio was evident in blends with a homogeneous dispersion type of morphology. After the phase inversion, when polyamide became the continuous phase, the barrier properties of the blends were significantly improved and approached those of polyamide 6. Increasing the amount of the compatibilizer, maleic anhydride grafted polypropylene, was found to increase the permeability of the blend. The blending procedure had a significant effect on the permeability of the blends. The injection‐molded blend exhibited a laminar type of morphology when polyamide 6 and the compatibilizer were preblended in a twin‐screw extruder, and polypropylene was added later as a dry‐blend before injection molding. The dispersed polyamide phase formed thin elongated platelets in the polypropylene matrix. This laminar morphology resulted in significant improvement of oxygen barrier properties approaching the level of the theoretical values calculated for corresponding coextruded structures. Moreover, both the tensile and impact properties of this particular blend were exceptionally good. © 1995 John Wiley &amp; Sons, Inc.
Images of the Cone Mosaic in the Living Human Eye (1995)

Land and Snyder 1 and Jagger 2 resolved single photoreceptors through the natural optics of the American garter snake and cane toad, respectively, capitalizing on their large photoreceptors and good optics. It is widely thought that the optical quality of the human eye is too poor relative to the grain of the cone mosaic to resolve photoreceptors in the living human eye. Nonetheless, we show here that when the pupil is large and aberrations are carefully corrected, the cone mosaic can occasionally be seen through the eye's natural optics. In eyes for which the cone mosaic cannot be imaged directly, information about cone spacing can often be obtained from the power spectra of retinal images.
Confocal endomicroscopy for the diagnosis of gastric cancer in vivo (2006)

Confocal endomicroscopy is useful in the diagnosis of gastric cancer but good quality images cannot always be obtained. In the future, it may allow virtual biopsy and help reduce unnecessary biopsies.
ChemInform Abstract: Asymmetric Activation (2001)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abstract 318: Multi-omics to edge into precision medicine for DIPG (2021)

Abstract Effective targeted cancer therapies are limited due to lack of our understanding of disease pathogenesis at the molecular level. Diffuse intrinsic pontine glioma (DIPG) is an incurable pediatric brain tumor with 80% of DIPGs harboring H3F3A (H3.3) mutation that lead to a substitution of methionine for lysine at position 27 (K27M). The tumors bearing H3.3K27M mutation arise throughout the midline structures with global depletion of H3.3K27 me3 (trimethylation). These histone mutations modify the epigenome and alter oncogenic transcription, causing oncogenic insults to progenitor cells in early neurodevelopment (PMID: 30453529). To determine the reprogramming pathways in the cell context of H3.3K27M tumors, we conducted liquid chromatography-mass spectrometry-based proteomic and phosphoproteomic analysis on seven patient-derived DIPG cell lines that can be stably passaged in serum-free neural stem cell media and displayed distinct morphologies, growth rates and chromosome abnormalities (PMID: 21368213). Three normal neuronal stem cell lines were included as non-tumor brain cells for comparison. Pathway analysis identified 29 pathways that are significantly altered in DIPG compared to normal brain cells at both the protein abundance and phosphosite level. Notably, AKT and MAPK associated PI3K signaling, VEGF signaling, mTOR signaling, and HIF1a signaling were differentially active in H3.3K27M tumors compared to healthy control cell lines. We saw significantly higher activity of multiple kinases involved in axon guidance and cytoskeletal remodeling in DIPG, such as PTK2B, DYRK2, TTBK2 and MARK2. This is the first time to report an increased abundance and kinase activity of Pyk2 protein (coded by PTK2B), a close homologue of FAK and its associated signaling in DIPG. Overexpression and autophosphorylation of Pyk2 are required to stimulate glioma cell migration (PMIDs: 15967096, 18648907). Pyk2 has also been proposed to act in concert with Src to link Gi- or Gq-coupled receptors with the mitogen-activated protein (MAP) kinase signaling pathway (PMID:12960403). Because of the shared signaling across kinase pathways, targeting activated Pyk2 in DIPG may complement inhibitors of other dysregulated signaling networks in DIPG such as MAPK2, VEGFR, PI3K and Src. Our data also found that IL13RA2 was upregulated in DIPG; others have shown that increased expression of IL13RA2 is associated with poor prognosis in GBM (PMIDs: 32913543, 30366424). We conclude that for H3 K27M DIPG tumors, campaigns to target Pyk2, MAPK2, VEGFR, PI3K, Src and IL13Ra2 using small molecules that traverse the blood brain barrier loom as promising opportunities for drug development. Citation Format: Nanyun Tang, Kristin Leskoske, Krystine Garcia-Mansfield, Ritin Sharma, Hannah Tolson, Patrick Pirrotte, Michael E. Berens. Multi-omics to edge into precision medicine for DIPG [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2021; 2021 Apr 10-15 and May 17-21. Philadelphia (PA): AACR; Cancer Res 2021;81(13_Suppl):Abstract nr 318.
Prognostic value of cancer stem cell expression and growth in glioblastoma (2008)

2004 Background: Cancer stem cells (CSCs) expressing the CD133 marker are a small fraction of tumorigenic cells responsible for glioblastoma development and spreading, and are relatively resistant to conventional radiotherapy and chemotherapy. To evaluate the prognostic value of CSC expression and growth. Methods: We investigated the relationship between patient death or disease progression and the in vitro growth potential of glioblastoma CSCs, CD133 and CD133/Ki67 expression by immunohistochemistry and immunofluorescence, in tumors of 44 glioblastoma patients treated with complete or partial tumorectomy, followed by radiotherapy combined with temozolomide treatment. Results: CSC cultures were obtained from 14 of the 44 tumors (32 percent). CSC generation was significantly associated with overall survival (OS) (p<0.001) and progression-free survival (PFS) (p<0.001). The time required for CSC expansion strongly correlated with OS (r=0.74; p=0.002) and PFS (r=0.85; p<0.001). The presence of ≥ 2% CD133+ cells in tumor lesions were significantly associated with OS p=0.02) and PFS (p=0.01). A very poor OS (p=0.007) and PFS (p=0.001) was observed among the 10 of the 44 patients whose tumors contained CD133+ cells expressing Ki67. A higher CD133 expression significantly associated with tumors generating CSCs (p=0.006), and correlated with a higher risk of death in patients with tumors generating CSCs in vitro (p=0.028). CD133/ki67 co-expression segregated patients with the worst outcome among those with tumor generating CSCs (p=0.036). The generation of CSCs and CD133/Ki67 co-expression emerged as significant independent prognostic factors, with an adjusted hazard ratio of 4.03 (95 percent confidence interval, 1.82 to 8.93; p<0.001) and 4.87 (95 percent confidence interval, 1.94 to 12.22; p<0.001), respectively. Conclusions: In vitro CSC growth and the presence of CD133+/Ki67+ cells may predict the survival of glioblastoma patients and are two considerable prognostic factors of disease progression and poor clinical outcome. No significant financial relationships to disclose.
AAV-Mediated Gene Therapy for Research and Therapeutic Purposes (2014)

Adeno-associated virus (AAV) is a small, nonenveloped virus that was adapted 30 years ago for use as a gene transfer vehicle. It is capable of transducing a wide range of species and tissues in vivo with no evidence of toxicity, and it generates relatively mild innate and adaptive immune responses. We review the basic biology of AAV, the history of progress in AAV vector technology, and some of the clinical and research applications where AAV has shown success.
Collective algorithms for sub-communicators (2012)

Collective communication over a group of processors is an integral and time consuming component in many high performance computing applications. Many modern day super- computers are based on torus interconnects and near optimal algorithms have been developed for collective communication over regular communicators on these systems. However, for an irregular communicator comprising of a subset of processors, the algorithms developed so far are not contention free in general and hence non-optimal. In this paper, we present a novel contention-free algorithm to perform collective operations over a subset of processors in a torus network. We also extend previous work on regular communicators to handle special cases of irregular communicators that occur frequently in parallel scientific applications. For the generic case where multiple node disjoint sub-communicators communicate simultaneously in a loosely synchronous fashion, we propose a novel cooperative approach to route the data for individual sub- communicators without contention. Empirical results demon- strate that our algorithms outperform the optimized MPI collective implementation on IBM's Blue Gene/P supercomputer for large data sizes and random node distributions.
Correction: Phevalin (aureusimine B)Production by Staphylococcus aureus Biofilm and Impacts on Human Keratinocyte Gene Expression (2012)

Staphylococcus aureus biofilms are associated with chronic skin infections and are orders of magnitude more resistant to antimicrobials and host responses. S. aureus contains conserved nonribosomal peptide synthetases that produce the cyclic dipeptides tyrvalin and phevalin (aureusimine A and B, respectively). The biological function of these compounds has been speculated to be involved in virulence factor gene expression in S. aureus, protease inhibition in eukaryotic cells, and interspecies bacterial communication. However, the exact biological role of these compounds is unknown. Here, we report that S. aureus biofilms produce greater amounts of phevalin than their planktonic counterparts. Phevalin had no obvious impact on the extracellular metabolome of S. aureus as measured by high-performance liquid chromatography-mass spectrometry and nuclear magnetic resonance. When administered to human keratinocytes, phevalin had a modest effect on gene expression. However, conditioned medium from S. aureus spiked with phevalin amplified differences in keratinocyte gene expression compared to conditioned medium alone. Phevalin may be exploited as potential biomarker and/or therapeutic target for chronic, S. aureus biofilm-based infections.
Glucose homeostasis and p75<sup>NTR</sup> (2012)

Comment on: Baeza-Raja B, et al. Proc Natl Acad Sci USA 2012; 109:5838-43.
Corrigendum: Bioassay-Guided Interpretation of Antimicrobial Compounds in Kumu, a TCM Preparation From Picrasma quassioides’ Stem via UHPLC-Orbitrap-Ion Trap Mass Spectrometer Combined With Fragmentation and Retention Time Calculation (2022)

[This corrects the article DOI: 10.3389/fphar.2021.761751.].
Rapid detection of JMH antibodies with recombinant Sema7A (CD108) protein and the particle gel immunoassay (2008)

Recombinant blood group proteins have the potential to replace RBCs as antigen carriers for identification of certain RBC alloantibodies.
Electromagnetic modeling and synthesis of supershaped dielectric lens antennas (2019)

A novel class of dielectric lens antennas is presented and detailed in this work. The geometry of the considered radiating elements is described by the Gielis formula which provides an effective means for describing a very broad variety of shapes by acting on a reduced number of parameters. This translates into the possibility of automatically reshaping the lens profile. Since the antenna radiation properties strongly depend on the geometry of lens, an automated optimization procedure could be devised, in order to identify the Gielis parameters, yielding the optimum antenna performance. To this end, a hybrid semi-analytical electromagnetic modelling approach, based on geometrical and physical optics, is used in combination with an enhanced quantum particle swarm optimization procedure to synthesize the optimal lens shape, and select the relevant dielectric material characteristics and feeding structure useful for matching an assigned radiation pattern mask. To assess the effectiveness and versatility of the proposed lens antenna synthesis approach, a dedicated investigation is conducted using rigorous full-wave electromagnetic analysis tools.
The association between daily blood pressure and catecholamine variability in normotensive working women. (1993)

Using ambulatory blood pressure monitors and timed urine collection techniques, blood pressure and the rates of urinary catecholamine excretion were compared across the work, home, and sleep environments of 45 women who perceived their work environment as most stressful (work stressed) and 35 women who perceived their home environment as equally or more stressful (home stressed) on the day of monitoring. The work-stressed women had higher systolic pressure at work (121 vs. 115; p < 0.05). There were no significant differences in diastolic pressure or the absolute levels of the catecholamines between the groups. However, the percent changes in blood pressure and catecholamines from work or home to sleep were significantly correlated in the work-stressed but not the home-stressed women (r values from 0.25 to 0.45, p < 0.05). The work-stressed and home-stressed women differed in their proportional make-up of several demographic characteristics, including having children (percentage of home-stressed women with children > work-stressed) (p < 0.05), ethnicity (percent of black home-stressed > work-stressed) (p < 0.01), and family history of hypertension (percentage of work-stressed > home-stressed) (0.05 < p < 0.10). These differences, in part, may have determined the daily patterns of perceived stress in the two groups of women. Overall, these findings suggest that work stress and/or the sociodemographic characteristics that may influence the perception of work stress may drive a daylong sympathetic response that increases blood pressure in working women.
Evaluation of EFL Incidence and Impacts of Novel NIV Home Therapy (2020)

<b>Rationale:</b> The Forced Oscillation Technique (FOT) using the Dellaca et al (2004) method has been shown to detect Expiratory Flow Lmitation (EFL). The current study evaluates a novel, non-invasive ventilation (NIV) therapy, using FOT and an auto titrating expiratory positive airway pressure (EPAP), for its ability to abolish EFL. <b>Methods:</b> Seven participants received NIV during two weeks of home use. An unreleased ventilator (BiPAP A40, Philips Respironics, USA) applied FOT and calculated ∆Xrs, where ∆Xrs &gt; 2.8 cmH20*s/L indicates EFL, and EPAP is increased to abolish EFL. The ventilator was set in S/T mode, EPAP range 4-20 cmH20, fixed pressure support of 6 cmH2O. <b>Results:</b> Fig. 1 shows the frequency of samples with EFL (above dotted line) and without, for a typical participant. ∆Xrs tends to cluster around 2.8 when EFL is abolished. Fig. 2 shows the distribution of ∆Xrs for all participants (77.3% ≤ 2.8). Also, ∆Xrs values &gt; 2.8 were quickly remedied; mean time to return ∆Xrs ≤ 2.8 was 6.03 min. <b>Conclusions:</b> These preliminary results suggest auto titration of EPAP to achieve ∆Xrs values ≤ 2.8 successfully abolishes EFL. This may provide an alternative to the standard of care for EFL.
New room temperature nematogens by cyano tail termination of alkoxy and alkylcyanobiphenyls and their anchoring behavior on metal salt-decorated surface (2019)

A series of cyano tail-terminated alkoxy and alkyl cyanobiphenyl compounds and some cyano-p-terphenyl derivatives were synthesized and mesogenic properties described. Comparison with the K series and M series indicates that the terminal cyano group generally enhances the supercooling of the molecules. Furthermore, several binary LC mixtures formed by the cyano tail-terminated compounds were found exhibiting promising room temperature nematic phases ranges comparable to the commercial quaternary mixture E7. The equimolar binary mixture of CN5OCB and CN7OCB shows homeotropic ordering at the metal salts-decorated surfaces and planar ordering at the free surface, which is consistent with GBE values we calculated. As such, these materials are promising candidates for sensor devices which display a rapid response to a variety of analytes.