gebhart/patrepeval huggingface dataset:
Power Module (MCPM) Inverter (2007)

The complete designstrategy (mechanical and electrical) ofa three-phase 100kW powerconverter utilizing silicon carbide (SiC) andsilicon-on-insulator (SOI) electronics is presented. Thedesignphilosophy focuses on sizereduction throughhightemperature operation (200+°C junction temperature). A lowpower, proof-of-concept prototype operating at4kW hasbeenbuilt andtested. Thepreliminary workrenders the100kW module75% thesize ofcomparable state-of-the art Siconverters ofthesamevoltage andpowerlevels. Thedesign approach makesuseoftheunique advantages ofSiCdevices whileincorporating thenecessary passive (capacitive and magnetic) technologies inordertocomplete a fully functional powermodule. Highpowerdensity isobtained through high density integration ofthecontrol and powerstages using multichip powermodule(MCPM)technology. Thescaling ofthe lowpowermoduletothefully fledged three-phase 100kW prototype SiCMCPM converter isanalyzed indetail.
Review of design solutions for high performance pulsed power converters (2012)

This paper presents a review of topological and control design solutions for improving the performance of pulsed power converters. High bandwidth, low ripple and high efficiency square pulse voltage generators are typical specification requirements for the new generation of power converters for physics and medical research domains. The first part of the paper presents the state of the art of relevant literature on design solutions, optimized for different industrial applications, which can be useful for the pulsed power domain. The second part discusses their pertinence and efficiency implications for pulsed power designs.
Immunosorbent AssayWhichUsesMonoclonal Antibodies forDetection ofGroupC Rotavirusest (1992)

A biotin-streptavidin-enhanced enzyme-linked immunosorbent assay (ELISA)whichuses monoclonal antibodies (MAbs) forthedetection ofgroupCrotaviruses was developed. Anassayinwhichplates were coated withthree pooled MAbsandbiotinylated polyclonal immunoglobulin G (IgG) (polyclonal antibody IPAbI) was usedasthedetector (MAbcapture-PAb detector) was found tobethemostsensitive andspecific oftheassays whenitwas compared withassaysinwhichplates were coated withpolyclonal antiserum anddetection was donewitheither biotinylated polyclonal antiserum (PAbcapture-PAb detector) orbiotinylated pooled MAbs (PAbcapture-MAb detector). TheMAb capture-PAb detector ELISAdetected 83%ofsamples confirmed to bepositive forgroup C rotaviruses, whereas thePAbcapture-PAb detector assaydetected 63%ofpositive samples andthePAbcapture-MAb detector assaydetected 65% ofpositive samples. Allthree procedures detected bothofthebovine andthetwohumangroupCrotaviruses, butnoneofthethree procedures detected fecal samples containing groupA andBrotaviruses orfecal samples negative forgroup C rotaviruses usedin this study. Thesensitivity oftheMAb capture-PAb detector ELISAwas determined byserially diluting fecal group C rotaviruses; antigens were detected inmaximal positive dilution rangesof1:1,000 to1:3,000 forthe samples tested. Onthebasis ofthecell culture immunofluorescence assayinfectivity titer ofsemipurified cell culture-passaged Cowdengroup C rotavirus, thesensitivity oftheMAb capture-PAb detection ELISAfor detection ofhomologous group C rotavirus was 53fluorescent focus units per ml. Epitope mappingbyuseof thebiotinylated MAbsina competition assaysuggested that our MAbs may bindtothreedifferent but overlapping epitopes. Theseresults suggest that theMAb capture-PAb detector ELISAcanbeusedtostudy the epidemiology ofgroup C rotaviruses inhumansandanimals. Rotaviruses areimportant etiological agents ofacute gastroenteritis inhumaninfants andneonatal animals worldwide(11,15,30,33,38).Theirgenomesconsist of11 segments ofdouble-stranded RNA.Rotaviruses belong to thefamily Reoviridae andhavebeenfurther subdivided into atleast sevenserogroups (serogroups A toG)onthebasis of their distinct antigenicities andtheelectropherotype migration patterns oftheir genomes inpolyacrylamide gels (15, 16, 25,26).Memberswithin eachserogroup sharecommon antigens that arethought toreside onthemajor inner capsid protein (2,3,8,18,28). Serogroups BtoG,ornon-group A rotaviruses, aremorefastidious intheir invitro growth requirements (30, 33). However, onegroupCporcine (Cowden)strain andonebovine(Shintoku) strain havebeen propagated inarhesus monkeykidney cell line, MA104(32, 37,39). Incontrast, groupA rotaviruses growmorereadily incell culture withtheaidofproteolytic enzymes, andthis hasfacilitated diagnosis ofinfections withthis serogroup by serological techniques (11, 15,19,38). Incomparison with thediagnosis ofgroupA rotaviruses, simple assays suchas enzyme-linked immunosorbent assays (ELISAs) forthedetection ofnon-group A rotaviruses arelacking primarily
Back Cover: Intramolecular Frustrated Lewis Pair with the Smallest Boryl Site: Reversible H<sub>2</sub> Addition and Kinetic Analysis (Angew. Chem. Int. Ed. 6/2015) (2015)

An ansa-aminoborane an intramolecular frustrated Lewis pair with the smallest Lewis acidic boryl site (BH2), predominantly exists in quenched dimeric form in solution. A monomeric species accountable for hydrogen activation is also present in equilibrium. In their Communication on page 1749 ff., I. Pápai, T. Repo et al. describe the reactivity of this frustrated Lewis pair towards H2 and the corresponding reaction mechanism.
Automatic Integration in the Design of a Microturbine Compact Recuperator (2006)

The first phase of the development of an automatic methodology for the design process of small gas turbine recuperators is presented. The different software tools are selected in order to be managed, in a successive step of the research, by means of a design-optimization platform, according to the concept of Multi Disciplinary Optimization (MDO). The methodology has been developed integrating a geometrical parametric model of the heat transfer surfaces, built inside an industrial CAD, a three dimensional meshing tool and a CFD solver. Final objectives of the research will be an optimization process designed to maximize the heat exchange rate and to minimize costs and fluid dynamics losses. The paper deals with the parameterization technique and the numerical model validation.
UH-PAM protocol v1 (2020)

The protocol outlines the fabrication process of UH-PAM, and it prompts you with the details to repeat and reproduce our works.
The effect of sulfate pre-treatment to improve the deposition of Au-nanoparticles in a gold-modified sulfated g-C<sub>3</sub>N<sub>4</sub>plasmonic photocatalyst towards visible light induced water reduction reaction (2016)

In continuation of our earlier work on Au-g-C<sub>3</sub>N<sub>4</sub> and to improve its activity further, Au incorporated sulfated carbon nitride (g-C<sub>3</sub>N<sub>4</sub>) has been designed by using a simple impregnation cum borohydrate reduction method for the visible light induced water reduction reaction for hydrogen generation. The photocatalysts were characterized using various instrumental methods such as PXRD, UV-Vis DRS, SEM, HR-TEM, XPS, PL and TRPL spectral analysis. Functionalisation by the -HSO<sub>3</sub> group and incorporation of AuNPs in the g-C<sub>3</sub>N<sub>4</sub> skeleton lead to the extension of its pi-conjugated system, modification of its semiconductor properties, such as band structure engineering with a tunable bandgap, red-shift of the optical absorption band and promotion of charge migration and separation. The sulfate pre-treated g-C<sub>3</sub>N<sub>4</sub> samples are supposed to have a defected surface due to oxygen vacancies, which increases the adsorption of AuNPs onto the vacant oxygen sites. Thus the AuNPs get adsorbed on the reduced surfaces, increasing the extent and effectiveness of the electronic communication between gold and the g-C<sub>3</sub>N<sub>4</sub> interface. The improved photocatalytic activity could be attributed to the surface plasmon resonance (SPR) effect of AuNPs, which synergistically facilitates the photocatalysis process. The photocatalytic activity of Au-sulfated g-C<sub>3</sub>N<sub>4</sub> for photocatalytic splitting of water to produce H<sub>2</sub> was increased 1.5 times compared to that of Au-g-C<sub>3</sub>N<sub>4</sub>, 2.5 times compared to that of sulphated-g-C<sub>3</sub>N<sub>4</sub> and 35 times compared to that of single-phase g-C<sub>3</sub>N<sub>4</sub>.
In vitro 2D and 3D cancer models to evaluate compounds that modulate macrophage polarization (2022)

In vitro cancer models that can identify novel immunomodulating compounds are essential. Using a 3D multicellular tumor spheroid (MCTS) model comprising cancer cells, fibroblasts, and macrophages, we tested tumor-associated macrophage (TAM)-inhibiting compounds (CCL2 Ab, CSF1R inhibitor, CSF1R Ab) and TAM-reprograming compounds (poly I:C, CD40 Ab, CD40 ligand) for their effects on monocyte infiltration and polarization in tumor spheroids. For characterization of macrophage polarization, we measured the expression of CD206, CD163, CD86, MHC II, CD40, and CD14 and measured 43 soluble factors in the 3D MCTS cultures. 2D macrophage models were evaluated for comparison. A CSF1R inhibitor prevented infiltration of monocytes into pancreatic cancer spheroids, and macrophages treated with the inhibitor showed decreased expression of M2 markers. Treatment with a CD40 ligand and poly I:C induced M1 macrophage polarization in our models. We propose that these models can be used to improve the drug screening process of anti-cancer immunotherapies targeting macrophages.
Monitoring viscosity in asphalt binders using an ultrasonic guided wave approach (2015)

A pulse-echo ultrasonic guided wave approach capable of monitoring the viscosity of asphalt binders as function of temperature is presented. The method consists of sending a torsional wave from one end of a cylindrical steel rod embedded in asphalt binder and receiving the reflected signals. Experiments were performed on several binders of different performance grades, at temperatures ranging from 25 to 180 0 C. First, the viscosity of the binders was measured using a rotational viscometer in accordance with ASTM standards. The change in signal strength of the end-of-waveguide reflection of the guided wave was also monitored for the same binders over the same range of temperatures. It was observed that the values obtained using the guided wave approach correlates well with the viscosity values obtained using the rotational viscometer. The method also appears capable of monitoring changes in viscosity due to aging of the binders. The method has the advantage of having no moving parts, which makes it attractive for the development of a system that is capable of monitoring viscosity in asphalt binders in the asphalt industry. Industrial applications examples are briefly summarized.
Activation of Signal Transducer and Activator of Transcription-5 in Prostate Cancer Predicts Early Recurrence (2005)

Stat5 activation in prostate cancer was associated with early disease recurrence (P = 0.0399). Importantly, active Stat5 also predicted shorter progression-free survival in intermediate Gleason grade prostate cancers (P = 0.0409). Stat5 activation remained an independent prognostic marker after adjusting for Gleason grade, pT stage, perineural invasion, or seminal vesicle infiltration in all patients (P = 0.0565) and in Gleason grade 3 or 4 patients (P = 0.0582). The results of this work also confirmed our previous finding of association of Stat5 activation with a high histologic grade of prostate cancer (R = 0.11, P = 0.033). In summary, our study shows that active Stat5 distinguished prostate cancer patients whose disease is likely to progress earlier; therefore, active Stat5 may be a useful marker for selection of more individualized treatment. The results of this study need to be validated in a large prospective cohort.
Specific Expression in Reproductive Tissues and Fate of a Mitochondrial Sterility-Associated Protein in Cytoplasmic Male-Sterile Bean (1995)

Andre R. Abad, Brian J. Mehrtens, Sally A. Mackenzie, Specific Expression in Reproductive Tissues and Fate of a Mitochondrial Sterility-Associated Protein in Cytoplasmic Male-Sterile Bean, The Plant Cell, Vol. 7, No. 3 (Mar., 1995), pp. 271-285
Modeling of an X-ray grating-based imaging interferometer using ray tracing (2020)

X-ray imaging by means of a grating-based Talbot-Lau interferometer has become an important tool for a wide variety of application areas such as security, medical and materials analysis. Imaging modalities include attenuation, differential phase contrast, and visibility contrast (or so-called dark field). We have developed a novel modeling approach based on ray tracing with commercially available software (Zemax OpticStudio) that yields image projections for all three modalities. The results compare favorably with experimental findings. Our polychromatic ray-based model accommodates realistic 3-D CAD objects with tailored materials properties and also allows for both surface and bulk scattering. As such, the model can simulate imaging of complicated objects as well as assist in a physical understanding of experimental projection details.
Aerostructural and Aeroacoustic Experimental Testing of Shape Memory Alloy Slat Cove Filler (2020)

A significant portion of overall noise created by aircraft during landing and approach can be attributed to the airframe. The slat, due to highly complex geometry, is a major contributor to this source of noise. The slat cove, in particular, produces flow separation and circulation, which is thought to be the mechanism behind slat noise production. A slat-cove filler (SCF) has been shown to be an effective tool in reducing slat related noise. A scaled Common Research Model (CRM) wing was used in the Texas A&M University 3 ft x 4 ft wind tunnel to demonstrate, for the first time experimentally, the acoustic noise reduction resulting from the implementation of a shape memory alloy (SMA) SCF across multiple flight conditions (flow velocity, angle of attack, and %-deployment), when compared to a slat with no SCF. Aerodynamic measures were compared between the two configurations as well, and showed minor variations in pressure distribution. Structural data was collected to further understand the displacement and strain of the SMA SCF under flow.
Preparation and characterization of cellulose monoacetates: the relationship between structure and water solubility (1991)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPreparation and characterization of cellulose monoacetates: the relationship between structure and water solubilityCharles M. Buchanan, Kevin J. Edgar, and Alan K. WilsonCite this: Macromolecules 1991, 24, 11, 3060–3064Publication Date (Print):May 1, 1991Publication History Published online1 May 2002Published inissue 1 May 1991https://pubs.acs.org/doi/10.1021/ma00011a005https://doi.org/10.1021/ma00011a005research-articleACS PublicationsRequest reuse permissionsArticle Views674Altmetric-Citations46LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
A diffuse interface method for solid-phase modeling of regression behavior in solid composite propellants (2021)

Solid composite propellants (SCPs) are ubiquitous in the field of propulsion. In order to design and control solid SCP rocket motors, it is critical to understand and accurately predict SCP regression. Regression of the burn surface is a complex process resulting from thermo-chemical-mechanical interactions, often exhibiting extreme morphological changes and topological transitions. Diffuse interface methods, such as phase field (PF), are well-suited for modeling processes of this type, and offer some distinct numerical advantages over their sharp-interface counterparts. In this work, we present a phase-field framework for modeling the regression of SCPs with varying species and geometry. We construct the model from a thermodynamic perspective, leaving the base formulation general. A diffuse-species-interface field is employed as a mechanism for capturing complex burn chemistry in a reduced-order fashion, making it possible to model regression from the solid phase only. The computational implementation, which uses block-structured adaptive mesh refinement and temporal substepping for increased performance, is briefly discussed. The model is then applied to four test cases: (i) pure AP monopropellant, (ii) AP/PBAN sandwich, (iii) AP/HTPB sandwich, and (iv) spherical AP particles packed in HTPB matrix. In all cases, reasonable quantitative agreement is observed, even when the model is applied predictively (i.e., no parameter adjustment), as in the case of (iv). The validation of the proposed PF model demonstrates its efficacy as a numerical design tool for future SCP investigation.
Experimental Demonstration and Potential Applications of a Tunable NRI Ferrite-Wire Metamaterial (2010)

The full-wave validation and experimental demonstration of a NRI metamaterial composed of an array of dielectrically insulated metal wires embedded in a ferrite substrate are reported. The simulation and experimental setup places a wedge-shaped NRI metamaterial in a parallel-plate waveguide structure and measures the refraction angles at the output of the wedge as a function of frequency and of the applied magnetic field using a circular array of tapered transmission lines, for setup size limitation and convenient matching. Moreover, two applications related to this setup are proposed: a real-time spectrum analyzer and a spatial demultiplexer.
NH tautomerization of 2,7,18,23-tetramethyl-3,8,12,13,17,22-hexaethylsapphyrin (1999)

A planar, pyrrole-in macrocyclic geometry is favored for 2,7,18,23-tetramethyl-3,8,12,13,17,22-hexaethylsapphyrin (SapH3) at all levels of protonation. This stands in marked contrast to 5,10,15,20-tetraphenylsapphyrin (TPSH3) where two structures, planar and inverted are known. The 1H NMR studies provide evidence consistent with the existence of tautomeric equilibria involving the neutral form of decaalkylsapphyrin and up to ten specific tautomeric species ({25-NH, 26-N, 27-NH, 28-N, 29-NH}, {25-NH, 26-NH, 27-N, 28-NH, 29-N}, {25-NH, 26-N, 27-NH, 28-NH, 29-N}, {25-N, 26-NH, 27-NH, 28-N, 29-NH}, {25-NH, 26-NH, 27-NH, 28-N, 29-N}, {25-N, 26-N, 27-NH, 28-NH, 29-NH}, {25-NH, 26-NH, 27-N, 28-N, 29-NH}, {25-NH, 26-N, 27-N, 28-NH, 29-NH}, {25-N, 26-NH, 27-NH, 28-NH, 29-N}, {25-N, 26-NH, 27-N, 28-NH, 29-NH}). Changes in the dynamics of these equilibria, rather than dimerization effects, are invoked to account for the splitting of 1H NMR resonances observed at low temperature. 1H NMR studies also reveal that decaalkylsapphyrin acts as a water and methanol binding receptor as evidenced by the upfield shift of water- or methanol-derived resonances. Under conditions of complexation, the water or methanol molecules are bound to the N5 center of the sapphyrin molecule via a network of hydrogen bonds.
Prevalence of the Metabolic Syndrome and Its Components (2004)

The MetS was extremely common in middle-aged subjects The high prevalence in men was mostly due to their high waist-to-hip ratio. The prevalence of the MetS increased in both sexes with deterioration in glucose regulation. Approximately 75% of the subjects with IGT had the MetS. Because the syndrome includes the major risk factors for atherosclerotic vascular diseases and is the major antecedent for type 2 diabetes, concerted preventive action should be targeted to control all the features of the MetS.
Salt-Induced Control of Supramolecular Order in Biocatalytic Hydrogelation (2012)

Biocatalytic action and specific ion effects are both known to have dramatic effects on molecular self-assembly and hydrogelation. In this paper, we demonstrate that these effects are highly cooperative. Biocatalytic hydrogelation of Fmoc peptides in the presence of salts combines kinetic (through enzymatic catalysis) and thermodynamic (specific ion and protein templating) contributions when applied in combination. Spectroscopic data (obtained by fluorescence spectroscopy and circular dichroism) revealed that hydrophobic interactions are greatly affected, giving rise to differential chiral organization and supramolecular structure formation. The kinetic effects of catalytic action could be removed from the system by applying a heat/cool cycle, giving insight into the thermodynamic influence of both protein and salt on these systems and showing that the effects of catalysis, templating, and salts are cooperative. The variable molecular interactions are expressed as variable material properties, such as thermal stability and mechanical strength of the final gel-phase material. To gain more insight into the role of the enzyme, beyond catalysis, in the underlying mechanism, static light scattering is performed, which indicates the different mode of aggregation of the enzyme molecules in the presence of different salts in aqueous solution that may play a role to direct the assembly via templating. Overall, the results show that the combination of specific salts and enzymatic hydrogelation can give rise to complex self-assembly behaviors that may be exploited to tune hydrogel properties.
EGFR associated expression profiles vary with breast tumor subtype (2019)

Abstract Background The epidermal growth factor receptor (EGFR/HER1) and its downstream signaling events are important for regulating cell growth and behavior in many epithelial tumors types. In breast cancer, the role of EGFR is complex and appears to vary relative to important clinical features including estrogen receptor (ER) status. To investigate EGFR-signaling using a genomics approach, several breast basal-like and luminal epithelial cell lines were examined for sensitivity to EGFR inhibitors. An EGFR-associated gene expression signature was identified in the basal-like SUM102 cell line and was used to classify a diverse set of sporadic breast tumors. Results In vitro, breast basal-like cell lines were more sensitive to EGFR inhibitors compared to luminal cell lines. The basal-like tumor derived lines were also the most sensitive to carboplatin, which acted synergistically with cetuximab. An EGFR-associated signature was developed in vitro, evaluated on 241 primary breast tumors; three distinct clusters of genes were evident in vivo, two of which were predictive of poor patient outcomes. These EGFR-associated poor prognostic signatures were highly expressed in almost all basal-like tumors and many of the HER2+/ER- and Luminal B tumors. Conclusion These results suggest that breast basal-like cell lines are sensitive to EGFR inhibitors and carboplatin, and this combination may also be synergistic. In vivo, the EGFR-signatures were of prognostic value, were associated with tumor subtype, and were uniquely associated with the high expression of distinct EGFR-RAS-MEK pathway genes.