gebhart/patrepeval huggingface dataset:
The role of insulin receptor substrate 2 in hypothalamic and β cell function (2005)

Insulin receptor substrate 2 (Irs2) plays complex roles in energy homeostasis. We generated mice lacking Irs2 in beta cells and a population of hypothalamic neurons (RIPCreIrs2KO), in all neurons (NesCreIrs2KO), and in proopiomelanocortin neurons (POMCCreIrs2KO) to determine the role of Irs2 in the CNS and beta cell. RIPCreIrs2KO mice displayed impaired glucose tolerance and reduced beta cell mass. Overt diabetes did not ensue, because beta cells escaping Cre-mediated recombination progressively populated islets. RIPCreIrs2KO and NesCreIrs2KO mice displayed hyperphagia, obesity, and increased body length, which suggests altered melanocortin action. POMCCreIrs2KO mice did not display this phenotype. RIPCreIrs2KO and NesCreIrs2KO mice retained leptin sensitivity, which suggests that CNS Irs2 pathways are not required for leptin action. NesCreIrs2KO and POMCCreIrs2KO mice did not display reduced beta cell mass, but NesCreIrs2KO mice displayed mild abnormalities of glucose homeostasis. RIPCre neurons did not express POMC or neuropeptide Y. Insulin and a melanocortin agonist depolarized RIPCre neurons, whereas leptin was ineffective. Insulin hyperpolarized and leptin depolarized POMC neurons. Our findings demonstrate a critical role for IRS2 in beta cell and hypothalamic function and provide insights into the role of RIPCre neurons, a distinct hypothalamic neuronal population, in growth and energy homeostasis.
Ventilation performance and indoor air pollutants diagnosis in 21 French low energy homes (2017)

An important challenge for low energy buildings lies in the need to master airflows through the building envelope. This paper describes a campaign on 21 low-energy houses. First, we carried out an aeraulic measurement campaign on every dwelling including visual survey, airflow or pressure at the air-vents, ventilation duct airleakage, and acoustics measurements. Then, we selected 10 dwellings to carry out an indoor air quality winter campaign. This campaign included outdoor and indoor measurements of temperature, relative humidity, carbon dioxide, chemical pollutants (VOC, aldehydes). Inhabitant habits and building influence were studied through a complementary questionnaire survey. With this campaign, we were able to identify ventilation dysfunctions and to compare them with the national statistics on dwelling stock. The second part of the measurement campaign allowed us also to identify links between aeraulic diagnoses and indoor pollutant measurements.
Identification of Preferred Distamycin−DNA Binding Sites by the Combinatorial Method REPSA (1997)

The combinatorial method restriction endonuclease protection, selection, and amplification (REPSA) was used to determine the preferred duplex DNA binding sites of the peptide N-methylpyrrolecarboxamide antibiotic distamycin A. After 12 rounds of REPSA, several sequences were identified that bound distamycin with an apparent affinity of 2-20 nM. Among these, the highest-affinity sites averaged 10 bp in length, suggesting that these sites may be occupied by multiple, cooperatively interacting distamycin molecules. Presently, REPSA is the only combinatorial approach that allows the identification of preferred DNA targets for small molecule ligands at physiologically relevant concentrations in solution. As such, it should prove useful in the design and screening of sequence-specific DNA-binding molecules.
Reaction of constrained bicyclic aminophosphines with cyclopentadienyltricarbonylmolybdenum(II) derivatives. Investigations into the basicity of the nitrogen site (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of constrained bicyclic aminophosphines with cyclopentadienyltricarbonylmolybdenum(II) derivatives. Investigations into the basicity of the nitrogen siteJocelyne Febvay, Francis Casabianca, and Jean G. RiessCite this: Inorg. Chem. 1985, 24, 20, 3235–3239Publication Date (Print):September 1, 1985Publication History Published online1 May 2002Published inissue 1 September 1985https://doi.org/10.1021/ic00214a029RIGHTS & PERMISSIONSArticle Views61Altmetric-Citations13LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (708 KB) Get e-Alerts Get e-Alerts
Short-Term Wind Power Prediction Method Based on Combination of Meteorological Features and CatBoost (2023)

As one of the hot topics in the field of new energy, short-term wind power prediction research should pay attention to the impact of meteorological characteristics on wind power while improving the prediction accuracy. Therefore, a short-term wind power prediction method based on the combination of meteorological features and CatBoost is presented. Firstly, morgan-stone algebras and sure independence screening(MS-SIS) method is designed to filter the meteorological features, and the influence of the meteorological features on the wind power is explored. Then, a sort enhancement algorithm is designed to increase the accuracy and calculation efficiency of the method and reduce the prediction risk of a single element. Finally, a prediction method based on CatBoost network is constructed to further realize short-term wind power prediction. The National Renewable Energy Laboratory (NREL) dataset is used for experimental analysis. The results show that the short-term wind power prediction method based on the combination of meteorological features and CatBoost not only improve the prediction accuracy of short-term wind power, but also have higher calculation efficiency.
Spectral Tuning of Localized Surface Phonon Polariton Resonators for Low-Loss Mid-IR Applications (2014)

Low-loss surface phonon polariton (SPhP) modes supported within polar dielectric crystals are a promising alternative to conventional, metal-based plasmonic systems for the realization of nanophotonic components. Here we show that monopolar excitations in 4H-silicon carbide nanopillar arrays exhibit an unprecedented stable efficiency even when the resonator filling fraction is varied by an order of magnitude. This provides a powerful mid-IR platform with excellent spectral tunability and strong field confinement. Combining IR spectroscopy measurements with full electrodynamic calculations, we elucidate the nature of the optical modes in these elongated subwavelength nanostructures by investigating their spectral behavior and local field dependence on the size and periodicity. The present study also gives a clear understanding and practical guidelines for the spectral tuning of localized SPhP and the coupling mechanisms at play. This work is integral with the development of phonon-polariton based applications for surface-enhanced infrared absorption spectroscopy (SEIRA), polychromatic detectors, and thermal imaging.
Supramolecular and Biomacromolecular Enhancement of Metal-Free Magnetic Resonance Imaging Contrast Agents (2019)

Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.
ChemInform Abstract: Catalysis by Means of Complex Ferrates (2011)

Abstract Review: 139 refs.
TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine‐directed cysteine residues (2012)

N-alpha-tosyl-L-phenylalanyl chloromethyl ketone (TPCK) has anti-tumorigenic properties, but its direct cellular targets are unknown. Previously, we showed TPCK inhibited the PDKl-dependent AGC kinases RSK, Akt and S6K1 without inhibiting PKA, ERK1/2, PI3K, and PDK1 itself. Here we show TPCK-inhibition of the RSK-related kinases MSK1 and 2, which can be activated independently of PDK1. Mass spectrometry analysis of RSK1, Aktl, S6K1 and MSK1 immunopurified from TPCK-treated cells identified TPCK adducts on cysteines located in conserved activation loop Phenylalanine-Cysteine (Phe-Cys) motifs. Mutational analysis of the Phe-Cys residues conferred partial TPCK resistance. These studies elucidate a primary mechanism by which TPCK inhibits several AGC kinases, inviting consideration of TPCK-like compounds in chemotherapy given their potential for broad control of cellular growth, proliferation and survival.
Sustained expression of the human protooncogene MYCN rescues rat embryo cells from senescence. (1988)

Amplification of the human gene MYCN may play a role in the malignant progression of human neuroblastomas. In pursuit of this possibility, previous studies have shown that the abundant expression of MYCN in cultured cells can elicit several aspects of the transformed phenotype. We now extend those findings by demonstrating that rat embryo cells transfected with MYCN can proliferate for at least 200 generations. Isolation of established cells was dependent on high expression of MYCN and on biological selection to eliminate untransfected cells. The established cells were not tumorigenic in syngeneic rats or athymic mice, failed to grow in soft agar, and required relatively high concentrations of serum for proliferation in culture. Our results show that enhanced expression of MYCN can rescue normal cells from senescence, add to the credentials of MYCN as an authentic protooncogene, and identify an additional biological activity that can be used in the characterization of MYCN.
Short-term perfluorocarbon liquid tamponade in choroidal melanoma endoresection (2022)

ST-PFCL tamponade may reduce the risk of intraoperative and postoperative complications associated with choroidal melanoma endoresection.
A 10‐item smell identification scale related to risk for Alzheimer's disease (2005)

University of Pennsylvania Smell Identification Test data from control subjects (n = 63), patients with mild cognitive impairment (n = 147), and patients with Alzheimer's disease (n = 100) were analyzed to derive an optimal subset of items related to risk for Alzheimer's disease (ie, healthy through mild cognitive impairment to early and moderate disease stages). The derived 10-item scale performed comparably with the University of Pennsylvania Smell Identification Test in classifying subjects, and it strongly predicted conversion to Alzheimer's disease on follow-up evaluation in patients with mild cognitive impairment. Independent replication is needed to validate these findings.
Orthostatic hypotension in Parkinson syndromes correlates to the degree of cardiac denervation assessed by HED PET (2005)

Background: Recently we demonstrated in a small cohort of patients that assessment of (postganglionic) sympathetic myocardial innervation using C-11-hydroxyephedrine (HED) and positron emission tomography (PET) might help to differentiate Parkinson syndromes. Our findings were in line with other reports using I-123-MIBG or F-18-Fluorodopamine as markers of adrenergic innervation.
Implanted neural electrodes cause chronic, local inflammation that is correlated with local neurodegeneration (2009)

Prosthetic devices that are controlled by intracortical electrodes recording one's 'thoughts' are a reality today, and no longer merely in the realm of science fiction. However, widespread clinical use of implanted electrodes is hampered by a lack of reliability in chronic recordings, independent of the type of electrodes used. One major hypothesis has been that astroglial scar electrically impedes the electrodes. However, there is a temporal discrepancy between stabilization of scar's electrical properties and recording failure with recording failure lagging by 1 month. In this study, we test a possible explanation for this discrepancy: the hypothesis that chronic inflammation, due to the persistent presence of the electrode, causes a local neurodegenerative state in the immediate vicinity of the electrode. Through modulation of chronic inflammation via stab wound, electrode geometry and age-matched control, we found that after 16 weeks, animals with an increased level of chronic inflammation were associated with increased neuronal and dendritic, but not axonal, loss. We observed increased neuronal and dendritic loss 16 weeks after implantation compared to 8 weeks after implantation, suggesting that the local neurodegenerative state is progressive. After 16 weeks, we observed axonal pathology in the form of hyperphosphorylation of the protein tau in the immediate vicinity of the microelectrodes (as observed in Alzheimer's disease and other tauopathies). The results of this study suggest that a local, late onset neurodegenerative disease-like state surrounds the chronic electrodes and is a potential cause for chronic recording failure. These results also inform strategies to enhance our capability to attain reliable long-term recordings from implantable electrodes in the CNS.
Energy Efficiency Cross Layer Protocol for Wireless Mesh Network (2014)

Wireless mesh network (WMN) is a novel emerging technology that will change the world more effectively and efficiently. It is regarded as a highly promising technology being increasingly important in mobile wireless networks of the future generation. In this paper, we consider energy management for wireless mesh networks from a point of view that started recently to attract the attention means the conservation of energy for operational and the environment reasons which is known as the Green Networking. This paper discusses different routing protocols to establish a protocol which considers energy efficiency. The existing protocols are compared using the basic functions of routing and the suggest protocol is designed to overcome some of their shortcomings. We are focusing on the conception of the cross-layer routing protocol that is implemented in TDMA (Time Division Multiple Access) wireless mesh networks based MAC protocol.
Human apolipoprotein B: partial amino acid sequence (1984)

A successful approach has been developed for the sequencing of apolipoprotein B based upon the procedure of Cleveland et al. [(1977) J. Biol. Chem. 252, 1102-1106] involving limited proteolysis in the presence of sodium dodecyl sulfate. Staphylococcus aureus protease was employed to produce large peptides which were isolated in relatively pure form by preparative gel electrophoresis. Two peptides were partially sequenced using spinning-cup microsequencing techniques. The sequences are: Peptide R2-5, -Ala-Leu-Val-Gly-Ile-Asn- Gly-Glu-Ala-Asn-Leu-Asp-Phe-Leu-Asn-Ile-Pro-Leu-Arg-Ile-Pro-Pro- Met-Arg-(Arg)-; Peptide R3-1, -Leu-Val-Ala-Lys-Pro-Ser-Val-Ser-Val-Glu- Phe-Val-Thr-Asn-Met-Gly-Ile-Ile-Pro-Lys-Phe-Ala-Arg-. Several stretches of residues suitable for the construction of oligonucleotide probes have been identified.
Nondestructive Mechanical Release of Ordered Polymer Microfiber Arrays from Porous Templates (2007)

The fabrication of one-dimensional (1D) nanostructures and microstructures inside the pores of porous templates is intensively investigated. The release of these structures is commonly accomplished by etching and destroying the templates. The 1D nanostructures and microstructures tend to condense because of the occurrence of capillary forces during drying of the specimens. It is shown that highly ordered arrays of polymer microfibers can be easily detached from silanized porous templates by mechanical lift-off. This procedure leaves the templates intact, thus allowing their recycling, and does not involve the use of solutions or solvents, thus circumventing condensation. Therefore, mechanical lift-off may enable the up-scaling of template-based approaches to the fabrication of highly ordered assemblies of 1D nanostructures and microstructures.
The Role of Multiscale Strain Localizations in Fatigue of Magnesium Alloys (2014)

The reliable characterization of fatigue behavior and progressive damage of advanced alloys relies on the monitoring and quantification of parameters such as strain localizations as a result of both crystallographic deformation mechanisms and bulk response. To this aim, this article attempts to directly correlate microstructural strain at specific fatigue life to global strain as well as surface roughness in Magnesium alloys. Strain at the grain scale is calculated using Digital Image Correlation (DIC), while surface topography gradients are computed using roughness data at different stages of the fatigue life. The results are further correlated to Electron Back Scatter Diffraction (EBSD) measurements which reveal the profuse and spatially inhomogeneous nature of the crystallographic deformation mechanisms related to yielding and fatigue crack initiation. Emphasis is given on using multimodal NDE data to formulate first a description of the current state of the material subjected to fatigue loading and on identifying conditions that can probabilistically drive the affected by both local and global response, governing degradation process.
Génération paramétrique spontanée dissymétrique en fréquence dans une fibre microstructurée (poster) (2013)

National audience
Phylogenetic relationships between extra-intestinal pathogenic Escherichia coli of human and avian origin (2005)

Communication orale C45*INRA C.R.Tours UR86 Base 37380 Nouzilly Diffusion du document : INRA C.R.Tours UR86 Base 37380 Nouzilly
Optimal scheduling of servers in a queueing system with constraints (packet radio networks) (2003)

The problem addressed considers random arrivals (or generation) of packets at the nodes and poses the question of (a) existence of schedules that guarantee finite queueing delays and/or (b) finding schedules that produce minimum queueing delay. As such a problem involves interacting queueing systems, it is not feasible to attempt to solve it for a PRN (packet radio network) of general topology. Instead the focus is on a simple tandem topology with elementary routing requirements. A set of N deterministic servers, the ith of which receives from exogenous sources customers at a Bernoulli rate of lambda /sub i/, is considered. The servers are ordered from 1 to N and they are constrained so that no two consecutive servers can be busy at the same time. This model represents a PRN in which there are N links connecting N+1 nodes in tandem and in which each of the first N nodes receives packets at rates lambda /sub i/ and wishes to deliver them to its neighbor on the right (the model can easily incorporate the case in which there are messages that need to be transmitted to the left neighboring node).< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Prediction of lumbar spine posture for repositioning of spinal FE model (2010)

This study presents a technique to reposition the spinal column in human body FE model's (FE HBM's) based on the trunk flexion or pelvis rotation angle. Representation of the spinal posture using natural splines is found to be an effective way of locating the position and orientation of the vertebrae when the spinal column is being flexed. Cobb and inter segmental angles obtained are in agreement to those reported in literature. It is also indicated in clinical studies that a simplified analysis of radiographs is possible by interpreting the position of only five key vertebrae.
Passivated SDD-Based Detection Unit to Improve Reliability in Scintillation Detection (2019)

The improvement of manufacturing technologies is the key aspect in nuclear science experiments. In this work we present the results of the development aimed to improve gamma detection modules based on the use of Silicon Drift Detectors (SDD). Previous attempts to build this type of detector showed issues in terms of reliability and robustess which limit the use of this solution in experiments. The introduction of a passivation layer based on deposition of optical resin on the light entrance window of the SDD allows to enhance robustness and to couple the Silicon detector to scintillators for gamma-ray spectroscopy. Experimental results show multiple times that no worsening of electronics noise is observed after resin deposition.
Neutron detection experiments with ionisation counter and /sup 6/Li converter (2003)

The detection of neutrons with thin /sup 6/Li containing films or layers within an ionisation chamber is discussed. A detection efficiency of 50% for thermal neutrons is obtainable with three 100/spl mu/m thin /sup 6/Li foils. Preliminary measurements were performed with converters which contain a 1/spl mu/m thin /sup 6/LiF layer. The detector efficiency is only 3%. Pulse height distributions were measured and analysed for the gases Ar, CF/sub 4/ and C/sub 2/F/sub 6/ at pressures between 0.5 atm and 5 atm and at voltages between 50V and 500V. Diffraction peaks from polycrystalline iron and semi-crystalline pyrolytic graphite were measured in TOF mode and are presented.
The Relative Importance of Visual, Auditory, and Haptic Information for the User's Experience of Mechanical Switches (2009)

While the use of hand tools and other everyday manually controlled devices is naturally accompanied by multisensory feedback, the deployment of fully multimodal virtual interfaces requires that haptic, acoustic, and visual cues be synthesised. The complexity and character of this synthesis will depend on a thorough understanding of the multimodal perceptual experience, including the interrelations between the individual sensory channels during manual interaction. In this study seventy participants were asked to rank the manual operation of ten electromechanical switches according to preference. The participants were randomly assigned in groups of ten to one of seven sensory presentation conditions. These conditions comprised six bimodal and unimodal sensory combinations created by selectively restricting the flow of haptic, auditory, and visual information, plus one condition in which full sensory information was available. A principal components analysis on the obtained ranking data indicated that the sensory conditions with unimpeded haptic information were clearly distinct from those in which the haptic cues were impeded. The analysis also showed that, for switch use, the unimodal haptic condition most closely approached the condition with combined haptic, auditory, and visual feedback, compared with all of the conditions where haptic feedback was restricted.