gebhart/patrepeval huggingface dataset:
Elevated Vacuum Suspension Influence on Lower Limb Amputee's Residual Limb Volume at Different Vacuum Pressure Settings (2010)

In Brief Lower limb amputees continue to contend with residual limb volume fluctuations. The stabilization of residual limb volume has the ability to increase comfort, reduce tissue breakdown, and improve daily function. Clinical evidence on elevated vacuum suspension has demonstrated the potential to maintain residual limb volume; however, the effect of different vacuum pressure settings has not been quantified. The purpose of this research is to gain outcome knowledge regarding elevated vacuum suspension and to investigate the effects of different vacuum pressure settings on lower limb amputee's residual limb volume. This single subject study focused on a K2 transtibial amputee new to elevated vacuum suspension with a history of residual limb volume fluctuations. The patient was fitted with a 0-ply total surface bearing socket that used the LimbLogic® VS. The percent change in volume was measured using the OMEGA® Tracer® volume feature at three treatment levels: absence of elevated vacuum (suction), vacuum (negative pressure) at 10 in Hg, and vacuum (negative pressure) at 15 in Hg. The results indicated a significantly less volume fluctuation with vacuum (0.8%) compared with suction (4.9%). Vacuum settings at 10 and 15 in Hg generated similar absolute percent changes in volume; however, 15 in Hg demonstrated a decreasing rate of change potentially suggesting a physiological alteration in the residual limb. During the duration of the study (3.5 months), an improvement was seen in volume retention with the length of vacuum suspension usage. In addition, the progressive healing of a distal wound was observed. As lower limb amputees continue to contend with residual limb volume fluctuations, it is important to understand the benefits the elevated vacuum can provide. Future research is necessary to investigate any physiological changes to the residual limb because of vacuum pressure settings. Vacuum suspension significantly improved volume retention compared with suction. Volume retention improved with the length of vacuum suspension usage, along with progressive healing of a distal wound. The authors believe future research is needed to investigate any physiological changes to the residual limb because of vacuum pressure settings and to fully understand the mechanisms associated with the ability to retain residual limb volume with elevated vacuum suspension.
Supplementary Figures 1-3 from Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors (2023)

Supplementary Figures 1-3 from Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors
A Process Model for Dashboard Onboarding (2022)

Abstract Dashboards are used ubiquitously to gain and present insights into data by means of interactive visualizations. To bridge the gap between non‐expert dashboard users and potentially complex datasets and/or visualizations, a variety of onboarding strategies are employed, including videos, narration, and interactive tutorials. We propose a process model for dashboard onboarding that formalizes and unifies such diverse onboarding strategies. Our model introduces the onboarding loop alongside the dashboard usage loop. Unpacking the onboarding loop reveals how each onboarding strategy combines selected building blocks of the dashboard with an onboarding narrative. Specific means are applied to this narration sequence for onboarding, which results in onboarding artifacts that are presented to the user via an interface. We concretize these concepts by showing how our process model can be used to describe a selection of real‐world onboarding examples. Finally, we discuss how our model can serve as an actionable blueprint for developing new onboarding systems.
Mast cell regranulation requires a metabolic switch involving mTORC1 and a glucose-6-phosphate transporter (2022)

Mast cells (MCs) are granulated cells implicated in inflammatory disorders because of their capacity to degranulate, releasing prestored proinflammatory mediators. As MCs have the unique capacity to reform granules following degranulation in vitro, their potential to regranulate in vivo is linked to their pathogenesis. It is not known what factors regulate regranulation, let alone if regranulation occurs in vivo. We report that mice can undergo multiple bouts of MC regranulation following successive anaphylactic reactions. mTORC1, a nutrient sensor that activates protein and lipid synthesis, is necessary for regranulation. mTORC1 activity is regulated by a glucose-6-phosphate transporter, Slc37a2, which increases intracellular glucose-6-phosphate and ATP during regranulation, two upstream signals of mTOR. Additionally, Slc37a2 concentrates extracellular metabolites within endosomes, which are trafficked into nascent granules. Thus, the metabolic switch associated with MC regranulation is mediated by the interactions of a cellular metabolic sensor and a transporter of extracellular metabolites into MC granules.
Iron- and Cobalt-Catalyzed Arylation of Azetidines, Pyrrolidines, and Piperidines with Grignard Reagents (2014)

Iron- and cobalt-catalyzed cross-couplings between iodo-azetidines, -pyrrolidines, -piperidines, and Grignard reagents are disclosed. The reaction is efficient, cheap, chemoselective and tolerates a large variety of (hetero)aryl Grignard reagents.
Combined passive acoustic mapping and magnetic resonance thermometry for monitoring phase-shift nanoemulsion enhanced focused ultrasound therapy (2017)

Focused ultrasound (FUS) has the potential to enable precise, image-guided noninvasive surgery for the treatment of cancer in which tumors are identified and destroyed in a single integrated procedure. However, success of the method in highly vascular organs has been limited due to heat losses to perfusion, requiring development of techniques to locally enhance energy absorption and heating. In addition, FUS procedures are conventionally monitored using MRI, which provides excellent anatomical images and can map temperature, but is not capable of capturing the full gamut of available data such as the acoustic emissions generated during this inherently acoustically-driven procedure. Here, we employed phase-shift nanoemulsions (PSNE) embedded in tissue phantoms to promote cavitation and hence temperature rise induced by FUS. In addition, we incorporated passive acoustic mapping (PAM) alongside simultaneous MR thermometry in order to visualize both acoustic emissions and temperature rise, within the bore of a full scale clinical MRI scanner. Focal cavitation of PSNE could be resolved using PAM and resulted in accelerated heating and increased the maximum elevated temperature measured via MR thermometry compared to experiments without nanoemulsions. Over time, the simultaneously acquired acoustic and temperature maps show translation of the focus of activity towards the FUS transducer, and the magnitude of the increase in cavitation and focal shift both increased with nanoemulsion concentration. PAM results were well correlated with MRI thermometry and demonstrated greater sensitivity, with the ability to detect cavitation before enhanced heating was observed. The results suggest that PSNE could be beneficial for enhancement of thermal focused ultrasound therapies and that PAM could be a critical tool for monitoring this process.
Brain endothelial tricellular junctions as novel sites for T cell diapedesis across the blood–brain barrier (2021)

The migration of activated T cells across the blood-brain barrier (BBB) is a critical step in central nervous system (CNS) immune surveillance and inflammation. Whereas T cell diapedesis across the intact BBB seems to occur preferentially through the BBB cellular junctions, impaired BBB integrity during neuroinflammation is accompanied by increased transcellular T cell diapedesis. The underlying mechanisms directing T cells to paracellular versus transcellular sites of diapedesis across the BBB remain to be explored. By combining in vitro live-cell imaging of T cell migration across primary mouse brain microvascular endothelial cells (pMBMECs) under physiological flow with serial block-face scanning electron microscopy (SBF-SEM), we have identified BBB tricellular junctions as novel sites for T cell diapedesis across the BBB. Downregulated expression of tricellular junctional proteins or protein-based targeting of their interactions in pMBMEC monolayers correlated with enhanced transcellular T cell diapedesis, and abluminal presence of chemokines increased T cell diapedesis through tricellular junctions. Our observations assign an entirely novel role to BBB tricellular junctions in regulating T cell entry into the CNS. This article has an associated First Person interview with the first author of the paper.
Conception systémique et gestion énergie – eau dans les processus de pompage et dessalement (2012)

National audience
Inhibition of gastric H plus , K plus -ATPase by novel thiazolidinone derivatives (2010)

The molecular modeling results along with the enzyme inhibition data generated practical knowledge to be explored in further structure-based drug design efforts in HAT drug discovery.
&lt;title&gt;New fully automatic method for CR image composition by white-band detection and consistency rechecking&lt;/title&gt; (2001)

This paper proposes a novel, fully automatic method for composing mosaic images in Computed Radiography. The method combines the detection of white-band edges with a cross- correlation technique. The white-band edges are positions of overlap lines. Several new kinds of measurements are proposed to evaluate the likelihood of a position to be a white-band edge. Multiple checks are used to reject less likely candidates. An error measure is defined for picking up the most likely candidates. The white-band candidate positions are fed to a cross-correlation method to compute the final alignment parameters for mosaic composition.
New-onset persistent left bundle branch block following sutureless aortic valve replacement (2022)

NOP-LBBB occurred in approximately a quarter of patients without prior conduction disturbances who underwent SU-SAVR and was associated with a threefold increased risk of PPI along with a negative impact on LVEF at follow-up.
Haliclonol, a New Tetrahydropyranone from the Caribbean Sponge Haliclona hogarthi (1992)

Haliclonol (2), a unique hydroxylated tyetrahydropyranone, was isolated from the Caribbean sponge Haliclona hogarthi, and its structure, including absolute stereochemistry, was elucidated by spectroscopic (ir, nmr, ms and cd) data
Systematic Mn d-configuration change in the<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">La</mml:mi></mml:mrow><mml:mrow><mml:mn>1</mml:mn><mml:mi mathvariant="normal">−</mml:mi><mml:mi mathvariant="normal">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">Ca</mml:mi></mml:mrow><mml:mrow><mml:mi mathvariant="normal">x</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math><mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mrow><mml:msub><mml:mrow><mml:mi mathvariant="normal">MnO</mml:mi></mml:mrow><mml:mrow><mml:mn>3</mml:mn></mml:mrow></mml:msub></mml:mrow></mml:math>system: A Mn K-edge XAS study (1997)

Systematic Mn K-edge x-ray-absorption spectroscopy (XAS) measurements on samples of ${\mathrm{La}}_{1\mathrm{\ensuremath{-}}\mathrm{x}}$${\mathrm{Ca}}_{\mathrm{x}}$${\mathrm{MnO}}_{3}$ are reported. Detailed results on the chemical shift and pre-edge feature spectral strength (both indicators of the Mn d-hole count) are discussed. The overall chemical shift across the series is compared to standard materials and is consistent with the identification of the endpoint perovskites with the ${\mathrm{Mn}}^{3+}$ and ${\mathrm{Mn}}^{4+}$ states. The detailed compositional dependence of the chemical shift and the strength of the pre-edge feature both indicate a uniform Ca-induced increase in the Mn d-hole count for x&gt;0.2 and an anomalous break from this behavior for x values less than x\ensuremath{\approx}0.2. Careful x-ray-diffraction measurements of the lattice parameter variation are also found to manifest changes near x\ensuremath{\approx}0.2 and the chemical shift results are shown to scale with the lattice parameter results. Additional XAS results on air prepared and oxygen annealed samples reveal a variation in the chemical shift response to excess oxygen across this series. These XAS results are discussed in terms of the important Mn d-hole count variation across this system.
Combining Whole-Genome Sequencing and Multimodel Phenotyping To Identify Genetic Predictors of <i>Salmonella</i> Virulence (2020)

<i>Salmonella</i> comprises more than 2,600 serovars. Very few environmental and uncommon serovars have been characterized for their potential role in virulence and human infections. A complementary <i>in vitro</i> and <i>in vivo</i> systematic high-throughput analysis of virulence was used to elucidate the association between genetic and phenotypic variations across <i>Salmonella</i> isolates. The goal was to develop a strategy for the classification of isolates as a benchmark and predict virulence levels of isolates. Thirty-five phylogenetically distant strains of unknown virulence were selected from the <i>Salmonella</i> Foodborne Syst-OMICS (SalFoS) collection, representing 34 different serovars isolated from various sources. Isolates were evaluated for virulence in 4 complementary models of infection to compare virulence traits with the genomics data, including interactions with human intestinal epithelial cells, human macrophages, and amoeba. <i>In vivo</i> testing was conducted using the mouse model of <i>Salmonella</i> systemic infection. Significant correlations were identified between the different models. We identified a collection of novel hypothetical and conserved proteins associated with isolates that generate a high burden. We also showed that blind prediction of virulence of 33 additional strains based on the pan-genome was high in the mouse model of systemic infection (82% agreement) and in the human epithelial cell model (74% agreement). These complementary approaches enabled us to define virulence potential in different isolates and present a novel strategy for risk assessment of specific strains and for better monitoring and source tracking during outbreaks.<b>IMPORTANCE</b><i>Salmonella</i> species are bacteria that are a major source of foodborne disease through contamination of a diversity of foods, including meat, eggs, fruits, nuts, and vegetables. More than 2,600 different <i>Salmonella enterica</i> serovars have been identified, and only a few of them are associated with illness in humans. Despite the fact that they are genetically closely related, there is enormous variation in the virulence of different isolates of <i>Salmonella enterica</i> Identification of foodborne pathogens is a lengthy process based on microbiological, biochemical, and immunological methods. Here, we worked toward new ways of integrating whole-genome sequencing (WGS) approaches into food safety practices. We used WGS to build associations between virulence and genetic diversity within 83 <i>Salmonella</i> isolates representing 77 different <i>Salmonella</i> serovars. Our work demonstrates the potential of combining a genomics approach and virulence tests to improve the diagnostics and assess risk of human illness associated with specific <i>Salmonella</i> isolates.
Ignition Delay Correlations for Neat Ethanol and Ethanol-DF2 Blends in a D.I. Diesel Engine (1984)

&lt;div class="htmlview paragraph"&gt;A study was conducted on a direct-injection, single-cylinder, research-type diesel engine to determine the effect of adding ethanol to diesel fuel on the ignition delay period. The tests covered the whole range of ethanol-DF2 blends: from 100% ethanol to 100% DF2. The test parameters were: the ethanol content, the intake-air properties, and the equivalence ratio. The ignition delay was measured by detecting the beginning of injection and the occurrence of a detectable pressure rise. The present results show that, for ethanol-DF2 blends, the pressure-rise delay decreases by increasing both the intake-air pressure and the intake-air temperature, and increases by increasing the ethanol content in the blend. Ignition delay correlations were developed in terms of air temperature, air pressure, and ethanol volumetric fraction. The global activation energy was determined and correlated with the cetane number for each blend.&lt;/div&gt;
Optical Resonance Engineering for Infrared Colloidal Quantum Dot Photovoltaics (2016)

We report optically enhanced infrared-harvesting colloidal quantum dot solar cells based on integrated Fabry–Perot cavities. By integrating the active layer of the photovoltaic device between two reflective interfaces, we tune its sensitivity in the spectral region at 1100–1350 nm. The top and bottom electrodes also serve as mirrors, converting the device into an optical resonator. The front conductive mirror consists of a dielectric stack of SiNx and SiO2 with a terminal layer of ITO and ZnO in which current can flow, while the back mirror consists of a highly reflective gold layer. Adjusting the reflectivity and central wavelength of the front mirror as well as the thickness of the active layer allowed increases in absorption by a total of 56% in the infrared, leading to a record external quantum efficiency of 60% at 1300 nm. This work opens new avenues toward low-cost, high-efficiency rear-junction photovoltaic harvesters that add to the overall performance of silicon solar cells.
TWEAK receptor-Fc suppresses germinal center formation and pathogenic B cells in lupus mice model via inhibition of TWEAK/Fn14 pathway (THER3P.1002) (2015)

Abstract Systemic lupus erythematosus (SLE) is autoimmune mediated chronic inflammatory diseases. Half of SLE patients suffer from lupus nephritis, and lupus nephritis is major cause of death in SLE. TWEAK/Fn14 interactions have been identified as pathologic factor in SLE pathogenesis. We conducted TWEAK/Fn14 pathway blocking by TWEAK receptor-Fc in SLE mice model and searched for the probable therapeutic mechanisms. CD19+ B cells were harvested from sanroque mice and TWEAK was administered. Sanroque mice were treated with TWEAK receptor-Fc or control-Fc for 3 weeks. Immunoglobulin (Ig) G, IgG1, IgG2a were measured in the sera of each group. Spleens from each group were stained with antibodies against CD4, B220, GL-7, CD138, and PD-1. Expression levels of mRNAs were determined by real-time PCR. Kidneys were stained with H&amp;E and PAS. Administration of TWEAK promoted B cell differentiation. Treatment with TWEAK receptor-Fc suppressed the levels of IgG, IgG1, and IgG2a in sera and reduced B cell, plasma cell, follicular helper T cell (Tfh) in spleen of sanroque mice. Additionally, renal protective effects of TWEAK receptor-Fc were demonstrated. In conclusion, TWEAK receptor-Fc had beneficial effects on SLE mice model by repressing auto-reactive B cell, plasma cell, Tfh, and renal damage. In futher, TWEAK receptor-Fc would be a potential therapeutic agent in SLE patient.
DIASTEREO ISOMERIC erythro AND threo FORMS OF 2,3-EPOXY-1-PHENYLPHOSPHOLANE 1-OXIDES SYNTHESIZED BY AN ACTION OF HYDROGEN PEROXIDE WITH BASE ON 1-PHENYL-2-PHOSPHOLENE 1-OXIDE (2004)

Article DIASTEREO ISOMERIC erythro AND threo FORMS OF 2,3-EPOXY-1-PHENYLPHOSPHOLANE 1-OXIDES SYNTHESIZED BY AN ACTION OF HYDROGEN PEROXIDE WITH BASE ON 1-PHENYL-2-PHOSPHOLENE 1-OXIDE was published on October 1, 2004 in the journal Heterocyclic Communications (volume 10, issue 4-5).
Economic Impact of the Introduction of Outpatient Medical Specialist Care (ASV) of Gastrointestinal Cancer Patients from a German Hospital Management Perspective (2020)

ASV leads to significant higher revenues across different ICD-subgroups for patients suffering from severe GIT. The collaboration of hospital and office-based physicians ensures patient-centered care with accumulated expertise and avoidance of double examinations. Thus, the inclusion of additional services in the Uniform Value Scale (invoiceable for ASV) is legitimated and enables cost-covering care for the involved parties.
Robust optical polarization of nuclear spin baths using Hamiltonian engineering of nitrogen-vacancy center quantum dynamics (2018)

Dynamic nuclear polarization (DNP) is an important technique that uses polarization transfer from electron to nuclear spins to achieve nuclear hyperpolarization. Combining efficient DNP with optically polarized nitrogen-vacancy (NV) centers offers promising opportunities for novel technological applications, including nanoscale nuclear magnetic resonance spectroscopy of liquids, hyperpolarized nanodiamonds as magnetic resonance imaging contrast agents, and the initialization of nuclear spin-based diamond quantum simulators. However, none of the current realizations of polarization transfer are simultaneously robust and sufficiently efficient, making the realization of the applications extremely challenging. We introduce the concept of systematically designing polarization sequences by Hamiltonian engineering, resulting in polarization sequences that are robust and fast. We theoretically derive sequences and experimentally demonstrate that they are capable of efficient polarization transfer from optically polarized NV centers in diamond to the surrounding <sup>13</sup>C nuclear spin bath even in the presence of control errors, making the abovementioned novel applications possible.
Abstract 2811: Allogeneic cell cased vaccine development by shared antigen screening (2014)

Abstract The fundamental premise of allogeneic vaccines for cancer relies upon the presence of common antigens that are shared between established cell lines and a large proportion of patients with histologically related tumors. Recent results from The Cancer Genome Atlas have clearly demonstrated that somatic mutations in exon region DNA, while potentially immunogenic, do not result in the translation of antigenic proteins that are similar from patient to patient. Instead, these data reinforce the concept that dysregulation of common pathways contributes to the general property of de-differentiation in tumor cells and the acquisition of immature phenotypes as compared to untransformed precursor cells. This phenomenon leads to expression of mucinous and embryonal antigens, collectively known as cancer testis antigens, that are otherwise rare in mature tissues and to which central tolerance remains incomplete. We have developed allogeneic vaccines based on parallel screening of non-small cell lung, bladder, triple-negative breast, ovarian and melanoma tumor cell lines and patient tumor samples. The baseline expression of certain antigens, including SSX2, SSX4, CT10, MAGE-A1, MAGE-A10, LAGE-1 and NY-ESO-1 was found to vary widely both between tumor samples and non-transformed tissue controls. Among all antigens screened, MAGE-A3 was most commonly upregulated across transformed tissue samples, however other antigens including BAGE-1, XAGE-1b and MAGE-A10 were found to be most dramatically upregulated. This analysis provides a screening tool with which to appropriately profile and prioritize individual cell lines for vaccine development in histologically diverse tumor types. Citation Format: Vadim V. Deyev, Neal Schilling, Taylor H. Schreiber. Allogeneic cell cased vaccine development by shared antigen screening. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 2811. doi:10.1158/1538-7445.AM2014-2811