gebhart/patrepeval huggingface dataset:
The Relevance of Computer-Aided-Diagnosis Systems in Microscopy Applications to Medicine and Biology (2011)

In this article, we discuss the use of computerbased systems in microscopy, focusing on cytological images. We initially present recent results on image segmentation, and then we argue that it makes sense moving from a structural approach to a semantic interpretation of micrographs. In this respect, we focus on the relevance of using CAD tools to overcome the current limitations of microscopy, investigating several peculiar objectives of such systems. A short review of the literature demonstrates that the development of a flexible CAD applicable to various working scenarios is a future trend in microscopy healthcare systems. To support our position, we briefly describe a tool that analyzes and classifies fluorescence images.Request access from your librarian to read this chapter's full text.
In-focus Cryo-EM Images Using a Hybrid Single-Sideband/Double-Sideband Aperture (2013)

Extended abstract of a paper presented at Microscopy and Microanalysis 2013 in Indianapolis, Indiana, USA, August 4 – August 8, 2013.
Photosynthesis Assimilate Partitioning in Closely Related Lines of Rice Exhibiting Different Sink:Source Relationships (1984)

Closely related rice ( Oryza sativa L.) genotypes differing in sink to source ratios were evaluated for photosynthetic gas exchange characteristics, nonstructural carbohydrate content, leaf parameters, and yield components. Lines with a high sink to source ratio exhibited higher rates of carbon exchange per unit leaf area and accumulated lower amounts of nonstructural carbohydrates in vegetative storage tissues than did other lines. The line with the lowest sink to source ratio accumulated the most carbohydrates in storage tissues. The results suggest that the photosynthetic potential of rice was not fully realized, and that an increase in the sink to source ratio might result in higher yields. The low source lines had high specific leaf weights, however, and that factor may have been largely responsible for perceived increases in photosynthetic rates. When expressed on a unit leaf weight or unit leaf protein basis, low source lines did not necessarily exhibit high source activity. The results indicate that sink:source ratios can be altered genetically, and that such manipulations can affect plant yields.
Combustion of carbon. Effect of sulfur dioxide (1977)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCombustion of carbon. Effect of sulfur dioxideRalph T. Yang and Meyer SteinbergCite this: J. Phys. Chem. 1977, 81, 11, 1117–1118Publication Date (Print):June 1, 1977Publication History Published online1 May 2002Published inissue 1 June 1977https://pubs.acs.org/doi/10.1021/j100526a018https://doi.org/10.1021/j100526a018research-articleACS PublicationsRequest reuse permissionsArticle Views40Altmetric-Citations8LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
The impact of photodynamic therapy therapy with polarity-tunable bacteriochlorins on the antitumor immunity: local effects and systemic consequences (Conference Presentation) (2019)

The main goal of this study is to analyze photochemical and molecular mechanisms of PDT with the set of polarity-tunable bacteriochlorins. The relationship of the structure and biological activity of the tested bacteriochlorins (F2BOH, F2BMet, F2BPrc, Cl2BHep) was determined, including (i) physicochemical, spectroscopic and photophysical characterization; (ii) the analysis of in vitro activity (cytotoxicity, subcellular localization, cell death modes); and (iii) the photodynamic efficacy in vivo (vascular versus cellular targeting). A detailed analysis of PDT-induced inflammation and a full characterization of molecular mechanisms were performed. The differences in the efficacy of the chosen phototherapeutic protocols (V-PDT, E-PDT, C-PDT) with optimized PDT conditions (Ps formulation, DLI, light dose) are demonstrated. To elucidate these differences, a Luminex technology was applied to detect a number of cytokines in the tumor and in plasma of PDT-treated mice. Among a wide range of cytokines (IL-6, IL-10, IL-13, IL-15) and chemokines (KC, MIP1, MIP2) released after PDT, an important role is assigned to IL-6. Moreover, expression of recombinant cytokines such as GM-CSF and TNFα significantly enhance antitumor response, whereas blocking anti-inflammatory cytokines such as IL-10 or VEGF improves the cure rates after PDT. Bacteriochlorin-mediated PDT generates specific immune response capable of inducing immunological memory that enables mice to reject a tumor rechallenge. Moreover, we have demonstrated that PDT activates innate and adaptive immunity that result in the eradication of NIR-irradiated primary tumors and the inhibition of untreated distant tumors by generating a systemic tumor-specific cytotoxic T-cell response.
Mid‐term results for the retroluminar transobturator sling suspension for stress urinary incontinence after prostatectomy (2010)

• With a mid-term follow-up, the retroluminar transobturator male sling is an effective, safe and attractive treatment option for SUI after radical prostatectomy. Results are stable over time.
A multi-channel microreactor dedicated to the electro-organic synthesis (2010)

International audience
Image electrocardiography based on a cardiac vector projection circle (2012)

Cardiac vector projection forms the basis of 12-lead electrocardiography (ECG). However, the spatial relationship between the leads is not obvious in 12-lead ECG. In addition, the lead strengths of the three augmented leads are insufficiently represented. In this paper, we propose a new image ECG, which represents the cardiac vector projection over a 360 degree spatial angle on an observation plane (frontal, horizontal, or sagittal plane) in 3D space. We also present a novel “cardiac vector circle” and mathematically demonstrate that the diameter of the circle equals the magnitude of the cardiac vector. The intersections between the “cardiac vector circle” and ECG leads determine the projected ECG lead strengths. We further demonstrate that the lead strengths of the three augmented leads of 12-lead ECG are only V3/2 that of the projected lead strengths; this finding shows that the lead strengths between the standard bipolar limb leads and the augmented limb leads are not on the same scale. Finally, we also illustrate that there exists an evolutional relationship between 12-ECG, vectorcardiography (VCG), and image ECG.
Ultrathin Coatings by Multiple Polyelectrolyte Adsorption/Surface Activation (CoMPAS) (1998)

A new versatile method for the preparation of thin polymer coatings is presented. It is based on the adsorption of reactive polyelectrolytes by electrostatic interactions. In a following activation step, the adsorbed polymers are modified by reacting with low molar mass reagents carrying the complementary charge, in order to induce charge reversal on the surface. This process allows regular layer-by-layer growth. Using coupling reactions that destroy or create dyes, in particular with donor−acceptor substitution, the multilayer growth can be easily followed. Coupling of azo dyes, aldol condensations of cyanine dyes and analogues, or Michael addition of reactive dyes was found to be particularly useful. The resulting multilayers inherently have a noncentrosymmetric structure.
Wettability Characterization in Textiles – Use and Abuse of Measuring Procedures (2017)

This chapter contains sections titled: Introduction Peculiarities of Textile Substrates Wettability Measurements on Fabrics Contact Angle Measurements on Fibers Summary and Concluding Remarks Acknowledgements
A Review of Alternative Electrical Power Distribution Methods for Future Unmanned Aerial Vehicles (2008)

&lt;div class="htmlview paragraph"&gt;Increasingly complex and challenging mission requirements for Unmanned Aerial Vehicles (UAVs) may in the future place demands on the vehicle electrical system. Direct current and high-frequency alternating current have been proposed as alternatives to conventional AC approaches in manned aircraft which may contribute to meeting these requirements. The paper reviews the advantages and disadvantages a number of power distribution options across a range of metrics likely to be of interest to UAV designers and operators including factors such as weight, fault management and electrical losses. Important technical challenges in the application of these technologies are identified.&lt;/div&gt;
Autoradiography and Fluorography of Acrylamide Gels (2003)

Autoradiography detects the distribution of radioactivity on gels or filters by producing permanent images on photographic film. It is frequently used in a variety of experimental techniques ranging from Southern and Northern blot analysis (), to visualization of radioactive proteins separated in a sodium dodecyl sulfate (SDS)-Poly-acrylamide gels (), to detection of nuclear factors bound to a labeled DNA probe in gel shift analysis (), and to localization of DNA bands in sequencing gels ().
How Strong are Passwords Used to Protect Personal Health Information in Clinical Trials? (2011)

If files containing sensitive patient information must be transferred by email, mechanisms to encrypt them and to ensure that password strength is high are necessary. More sophisticated collaboration tools are required to allow file sharing without password sharing. We provide recommendations to implement these practices.
Molecular dynamics simulations using the drude polarizable force field on GPUs with OpenMM: Implementation, validation, and benchmarks (2018)

Presented is the implementation of the Drude force field in the open-source OpenMM simulation package allowing for access to graphical processing unit (GPU) hardware. In the Drude model, electronic degrees of freedom are represented by negatively charged particles attached to their parent atoms via harmonic springs, such that extra computational overhead comes from these additional particles and virtual sites representing lone pairs on electronegative atoms, as well as the associated thermostat and integration algorithms. This leads to an approximately fourfold increase in computational demand over additive force fields. However, by making the Drude model accessible to consumer-grade desktop GPU hardware it will be possible to perform simulations of one microsecond or more in less than a month, indicating that the barrier to employ polarizable models has largely been removed such that polarizable simulations with the classical Drude model are readily accessible and practical.
Construction of a Diverse Range of Boron Heterocycles via Ring Expansion of a Carboranyl‐Substituted 9‐Borafluorene (2023)

Direct insertion of unsaturated substrates into a five-membered borole ring is a useful method to obtain valuable heterocycles containing one or more three-coordinate boron atoms. A highly Lewis acidic 9-o-carboranyl-9-borafluorene, in which the o-carboranyl substituent is connected via one of the cluster carbon atoms to the boron atom of the 9-borafluorene unit, was found to react with a vast array of unsaturated molecules, such as alkynes, aldehydes and various organic azides, to form larger boraheterocyclic products. The ring expansion reactions of the central borole ring proceed rapidly at room temperature, cementing the role of the o-carboranyl substituent in enhancing the insertion reactivity of 9-borafluorenes.
Natural Products Extracted from Fungal Species as New Potential Anti-Cancer Drugs: A Structure-Based Drug Repurposing Approach Targeting HDAC7 (2020)

Mushrooms can be considered a valuable source of natural bioactive compounds with potential polypharmacological effects due to their proven antimicrobial, antiviral, antitumor, and antioxidant activities. In order to identify new potential anticancer compounds, an <i>in-house</i> chemical database of molecules extracted from both edible and non-edible fungal species was employed in a virtual screening against the isoform 7 of the Histone deacetylase (HDAC). This target is known to be implicated in different cancer processes, and in particular in both breast and ovarian tumors. In this work, we proposed the ibotenic acid as lead compound for the development of novel HDAC7 inhibitors, due to its antiproliferative activity in human breast cancer cells (MCF-7). These promising results represent the starting point for the discovery and the optimization of new HDAC7 inhibitors and highlight the interesting opportunity to apply the "drug repositioning" paradigm also to natural compounds deriving from mushrooms.
Supplementary Table S1 from Effect of Altering Dietary ω-6/ω-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2, and Prostaglandin E&lt;sub&gt;2&lt;/sub&gt; (2023)

Supplementary Table S1 from Effect of Altering Dietary ω-6/ω-3 Fatty Acid Ratios on Prostate Cancer Membrane Composition, Cyclooxygenase-2, and Prostaglandin E&lt;sub&gt;2&lt;/sub&gt;
Transition from Transesophageal Echocardiography to Cardiac Computed Tomography for the Evaluation of Left Atrial Appendage Thrombus Prior to Atrial Fibrillation Ablation and Incidence of Cerebrovascular Events During the COVID-19 Pandemic (2021)

Background Transesophageal echocardiography (TEE) is variably performed before atrial fibrillation (AF) ablation to evaluate left atrial appendage (LAA) thrombus. We describe our experience with transitioning to the pre-ablation cardiac computed tomography (CT) approach for the assessment of LAA thrombus during the COVID-19 pandemic. Methods We studied consecutive patients undergoing AF ablation at our center. The study cohort was divided into pre- vs. post-COVID groups. The pre-COVID cohort included ablations performed during 1 year before the COVID-19 pandemic; pre-ablation TEE was used routinely to evaluate LAA thrombus in high-risk patients. Post-COVID cohort included ablations performed during the 1 year after the COVID-19 pandemic; pre-ablation CT was performed in all patients, with TEE performed only in patients with LAA thrombus by CT imaging. The demographics, clinical history, imaging, and ablation characteristics, and peri-procedural cerebrovascular events (CVE) were recorded. Results A total of 637 patients (pre-COVID n=424, post-COVID n=213) were studied. The mean age was 65.6  10.1 years in the total cohort, and the majority were men. There was a significant increase in pre-ablation CT imaging from pre to post-COVID cohort (74.8 vs. 93.9%, p=&lt;0.01), with a significant reduction in TEEs (34.6 vs. 3.7%, p=&lt;0.01). One patient in the post-COVID cohort developed CVE following negative pre-ablation CT. However, the incidence of peri-procedural CVE between both cohorts remained statistically unchanged (0 vs. 0.4%, p=0.33). Conclusion Implementation of pre ablation CT-only imaging strategy with selective use of TEE for LAA thrombus evaluation is not associated with increased CVE risk during the COVID- 19 pandemic.
Suspension bead array branch migration displacement assay for rapid STR analysis (2008)

STR analysis is commonly used in forensic and genetic studies. STRs are currently discriminated based on size, primarily by gel- and column-based approaches. Hybridization-based approaches have the potential to allow high-throughput analysis of STRs; however, development of such approaches has been limited by the difficulty in discriminating between STRs of similar length. We have recently described several innovations to enable STR analysis using an array-based hybridization approach for high- throughput STR analysis. Here we extend that approach by incorporating the array into microspheres and adding a discriminatory branch migration displacement step. This microsphere-based platform uses Luminex xMAP technology and improves the sensitivity, selectivity, and speed of the assay. We demonstrate the feasibility, speed, and reliability of the assay for STR detection by correctly analyzing two STR loci in 20 forensic DNA samples of known STR type. The multiplex, bead-based approach provides a high-throughput and more portable STR analysis.
Rhenium(V) Complexes as Cysteine-Targeting Coordinate Covalent Warheads (2023)

Interest in covalent enzyme inhibitors as therapeutic agents has seen a recent resurgence. Covalent enzyme inhibitors typically possess an organic functional group that reacts with a key feature of the target enzyme, often a nucleophilic cysteine residue. Herein, the application of small, modular Re<sup>V</sup> complexes as inorganic cysteine-targeting warheads is described. These metal complexes were found to react with cysteine residues rapidly and selectively. To demonstrate the utility of these Re<sup>V</sup> complexes, their reactivity with SARS-CoV-2-associated cysteine proteases is presented, including the SARS-CoV-2 main protease and papain-like protease and human enzymes cathepsin B and L. As all of these proteins are cysteine proteases, these enzymes were found to be inhibited by the Re<sup>V</sup> complexes through the formation of adducts. These findings suggest that these Re<sup>V</sup> complexes could be used as a new class of warheads for targeting surface accessible cysteine residues in disease-relevant target proteins.
Impact of hypothermia on implementation of CPAP for neonatal respiratory distress syndrome in a low-resource setting (2018)

The results of our study suggest that successful implementation of CPAP to treat RDS in low-resource settings will require aggressive action to prevent persistent hypothermia. However, our results show that even babies who are initially cold can do well on CPAP with proper management of hypothermia.
STUDY ON THE GREEN-SHADE SELECTION BEHAVIOR OF PARK USERS UNDER HIGH SUMMER TEMPERATURES (2018)

大阪市営長居公園において，夏季の暑熱環境下における利用者の緑陰の選択行動と，温熱環境との関連性を調査した．その結果，WBGTが27.5℃を超える暑熱環境下では，WBGTが1.0℃上昇すると緑陰の茂みを選択する歩行者の割合が2.2～2.4％増加した．走行者に関しては，WBGTが1.0℃上昇すると，歩道日陰を選択する割合は4.5～5.5％増加し，車道日陰を選択する割合が減少した．また，普段，あまり公園を利用しない人は，日常的に公園を利用している人よりも多く日陰を選択する傾向が認められた．WBGTが30.0℃を超えた状態では9割以上の人が，目的地に対して遠回りになるにも関わらず日陰空間を選択しており，このような人に対して屋外サービスを提供する場合は，より多くの日陰空間を確保する必要がある．
FINANCING RISK MANAGEMENT AND CONTROL FOR HIGH-TECHNOLOGICAL SMALL AND MEDIUM ENTERPRISES — UNDER NONLINEAR DIFFERENTIAL EQUATION (2021)

In this paper, a financing decision-making method is proposed based on the nonlinear differential equations (NDEs) to promote the healthy development of high-technological (high-tech) small and medium enterprises (SMEs). An assessment index system for financing risks is established, and the financing decision-making method is proposed based on the backward stochastic differential equation (BSDE). Then, the financing risk is evaluated with analytic hierarchy process (AHP) combined with fuzzy evaluation based on the financing status of Peilin Company. Finally, the corresponding financing decision is proposed based on the BSDE. It is found that the comprehensive score of financing risk of Peilin Company is 63.6124, indicating that the risk is high. The financing decision obtained shows that the current equity fund financing should be 396.24[Formula: see text]million to achieve the future goal. It is proved that the proposed financing risk evaluation method can assess the financing risks accurately, and the financing decision-making method based on NDE can obtain more appropriate financing decisions through calculation. This study can provide a crucial reference for management and control of financing risk for enterprises.
Supplementary Figure Legends 1-7 from The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt; (2023)

Supplementary Figure Legends 1-7 from The Neurofibromatosis Type 1 Tumor Suppressor Controls Cell Growth by Regulating Signal Transducer and Activator of Transcription-3 Activity &lt;i&gt;In vitro&lt;/i&gt; and &lt;i&gt;In vivo&lt;/i&gt;
In-Situ Synthesis of Silicon/Polyaniline Core/Shell and Its Electrochemical Performance for Lithium-Ion Batteries (2013)

Si/PANI core/shell composite is simply synthesized by an in-situ chemical polymerization method. The images of the obtained Si/PANI composites show that an amorphous PANI layer is adsorbed evenly on the nano-Si surface with a thickness of about 6 nm, forming the Si/PANI core/shell structure. It is observed that the Si/PANI anodes display the well cycling stability at a high rate of 1 C with the cutoff potential window of 0.01 V and 1.5 V. The initial charge capacity is 2083.8 mAh g−1, 1015.9 mAh g−1 and 583.6 mAh g−1 for the Si/PANI anodes containing 70 wt%, 50 wt% and 30 wt% PANI, respectively. Over 100 cycles, the capacity is kept at 889.6 mAh g−1, 672.5 mAh g−1 and 545.3 mAh g−1, respectively. Furthermore, the reversible capacity of the Si/PANI anode containing 70 wt% PANI still maintains at 1087.8 mAh g−1 even at the rates of 1 C, 0.5 C and 0.2 C after each 100 cycles. The results indicate that the PANI shell accommodates the large volume expansion and shrinkage of Si core during the lithium intercalation and extraction process, which facilitates the contact of electrode materials, thus ensures the higher discharge and charge capacity and better cycling stability.
Functionalization of commercial pigment Hostasol Red GG for incorporation into organic thin-film transistors (2019)

We explored the functionalization of the inexpensive commercial dye Red GG through a simple one-pot Grignard reaction leading to novel substituted derivatives that were incorporated into organic thin film transistors.