gebhart/patrepeval huggingface dataset:
A Cross-Version Approach For Stabilizing Tempo-Based Novelty Detection. (2012)

[TODO] Add abstract here.
Generation of permanent second-order susceptibility in lead-silicate glass fibers (1990)

The creation of a permanent second-order susceptibility [ χ (2) ] for second-harmonic generation (SHG) in Ge-doped silica fibers has been reported by several authors using various techniques (exposure to IR, 1 . seeding with IR and its second harmonic, 2 dc-field poling with blue light, 3 and de field only 4 ). Although the microscopic mechanism governing this interesting phenomenon is still not fully understood, it has been suggested that the alignment of defect centers plays an essential role. 5 Defect centers, however, are known to exist or can be induced in many amorphous materials, including a variety of compound glasses that are commercially available. These commercially available compound glasses provide a wide range of options for the fiber core and cladding materials. Moreover, the effect observed to date in Ge-doped silica fibers may be present in a different and stronger form in fibers fabricated from compound glasses. It is therefore interesting to study fibers fabricated from various compound glasses. In this paper we report the first results, to our knowledge, for the dc-field poling effect in lead-silicate glass fibers.
On the Implementation and Security Analysis of Routable-GOOSE Messages Based on IEC 61850 Standard (2022)

Advanced smart grid applications such as wide-area monitoring, protection, and control (WAMPAC), considerably depend on the synchrophasor measurements gathered from different locations of the power grid. These timestamped measurements are provided by Phasor measurement units (PMUs) and phasor data concentrators (PDCs). These devices are optimally deployed at selected nodes in the grid. PMUs and substation PDCs are routable protocol-based network devices and comply with the IEEE C37.118 standard. Since the PMUs generally communicate through a public wide area network, they are vulnerable to cyberattacks. As a result, these vulnerabilities lead to compromised data integrity, confidentiality, and availability of the smart grid. To cover the cybersecurity vulnerabilities in synchrophasor communication and achieve compatibility between the data transfer based on IEEE C37.118.2 with IEC 61850 standard, IEC 61850-90-5 was released. This part of the standard includes security measures to achieve authentication, integrity, and confidentiality if required. In this work, we implemented publisher and subscriber libraries capable of routing secure GOOSE messages while respecting the time delay specifications set by the IEC61850 standard. The performance of encryption and authentication algorithms was assessed and experimentally verified. In addition, the proposed framework's robustness against cyber-attacks was evaluated.
AMINOETHYL-ISOTHIOUREA IN GRAM-POSITIVE SHOCK: AN INHIBITOR OF INDUCIBLE NITRIC OXIDE SYNTHASE OR A JACK-OF-ALL-TRADES? (2001)

Department of Experimental Medicine and Nephrology, William Harvey Research Institute, St. Bartholomew's and the Royal London School of Medicine and Dentistry, London EC1M6BQ, United Kingdom Address reprint requests to Dr. Christoph Thiemermann, Department of Experimental Medicine and Nephrology and the Royal London School of Medicine and Dentistry, Charterhouse Square, London ECIM 6BQ, United Kingdom.
Source identification by non-negative matrix factorization combined with semi-supervised clustering (2023)

Machine-learning methods and apparatus are provided to solve blind source separation problems with an unknown number of sources and having a signal propagation model with features such as wave-like propagation, medium-dependent velocity, attenuation, diffusion, and/or advection, between sources and sensors. In exemplary embodiments, multiple trials of non-negative matrix factorization are performed for a fixed number of sources, with selection criteria applied to determine successful trials. A semi-supervised clustering procedure is applied to trial results, and the clustering results are evaluated for robustness using measures for reconstruction quality and cluster separation. The number of sources is determined by comparing these measures for different trial numbers of sources. Source locations and parameters of the signal propagation model can also be determined. Disclosed methods are applicable to a wide range of spatial problems including chemical dispersal, pressure transients, and electromagnetic signals, and also to non-spatial problems such as cancer mutation.
L-band sea surface emissivity radiometric observations under high winds: Preliminary results of the Wind and Salinity Experiment WISE-2001 (2003)

The WISE 2000 and WISE 2001 field campaigns were sponsored by ESA to gather experimental data to improve the knowledge of the L-band brightness temperature dependence with wind speed at different incidence angles and azimuth angles. The goal is to help the development of sea surface salinity retrieval algorithms for SMOS Earth Explorer Mission of the European Space Agency. The L-band AUtomatic RAdiometer (LAURA) plus other sensors to characterize the sea surface state were installed at the Casablanca oil rig, 40 km south east off the coast of Tarragona in Spain. During WISE 2000 wind conditions were low-to-moderate, but during WISE 2001 two strong storms beat the Catalonian coast with sustained winds higher than 100 km/h at the platform meteorological station (69 m height). The first results of the radiometric measurements (azimuth and elevation scans) acquired with LAURA during the WInd and Salinity Experiment (WISE-2001) are presented.
Surgically targeted radiation therapy (STaRT) for recurrent glioblastoma: Initial outcomes from a prospective multicenter registry. (2023)

2038 Background: Surgically targeted radiation therapy (STaRT), using a novel bioresorbable collagen brachytherapy device containing 4 Cesium-131 sources, is FDA-cleared for use as adjuvant radiation therapy (RT) post-resection in both newly diagnosed and recurrent intracranial neoplasms. Intraoperative initiation of brachytherapy potentially minimizes post-resection tumor regrowth with a favorable dosimetric profile compared to external beam radiation. This work sought to determine early patterns of care and the safety of this approach in recurrent GBM. Methods: This prospective multi-institutional observational study (NCT04427384) included recurrent GBM patients who underwent maximum safe resection (MSR) and permanent implantation of the device(s) (GammaTile, GT Medical Technologies, Tempe, AZ, US). Descriptive and comparative analyses regarding patient characteristics and early clinical outcomes were performed. Toxicities were categorized using the CTCAE v5.0 adverse event (AE) criteria. Results: During 10/2020–01/2023, 14 participating sites enrolled 45 patients with recurrent GBM for STaRT; 2 patients had two sites treated for a total of 47 implants. 67% of patients were treated at the first recurrence, 24% at the second, and 13% at the third, respectively. The median age was 61 (range 28-75), 36% were female, and 23% were &gt; 65 years. 85% of patients received prior same-site RT with the median time from last RT to implantation of 14.6 months (range 3.5-57). The median maximum preoperative size was 4.2 cm (range 1.6-7.0) and the median volume was 20.8 cm 3 (range 0.8-130). 68% of resections were gross-total, 17% near-total, and 15% sub-total; the median time needed for device implantation was 5 minutes (range 1.0-13). Median follow-up was 5.2 months (range 0.6-23.2). Median Karnofsky performance status (KPS) at screening, at initial postoperative assessment, and 3 months were all 80 (range 40-100). 7 attributed AEs occurred in 13% (6/45) of patients, all grade 3 AEs: 2 CSF leaks, 2 seizures, 1 cerebral edema, 1 pseudomeningocele, and 1 left hemiparesis. All except one were coded as related to both radiation and surgery; the patient with pseudomeningocele experienced a seizure at 47 days that was considered related to radiation alone. Conclusions: Early data from this prospective registry demonstrate the feasibility and safety of STaRT in recurrent GBM. Data on 6-month progression-free survival will be presented at the conference. A prospective randomized trial of adjuvant systemic therapy (AST) +MSR+STaRT versus MSR+AST is planned for initiation in 2023.
Identification of novel mutations causing familial primary congenital glaucoma in Indian pedigrees. (2002)

The molecular mechanism leading to the development of PCG is unknown. Because CYP1B1 knockout mice did not show a glaucoma phenotype, the functional knockout identified in this study has important implications in elucidating the pathogenesis of PCG. Further understanding of how this molecular defect leads to PCG could influence the development of specific therapies. This is the first study to describe the molecular basis of PCG from the Indian subcontinent and has profound and multiple clinical implications in diagnosis, genetic counseling, genotype-phenotype correlations and prognosis. Hence, it is a step forward in preventing this devastating childhood blindness.
Randomized Addition of Sensitive Attributes for l-diversity (2014)

When a data holder wants to share databases that contain personal attributes, individual privacy needs to be considered. Existing anonymization techniques, such as l-diversity, remove identifiers and generalize quasi-identifiers (QIDs) from the database to ensure that adversaries cannot specify each individual's sensitive attributes. Usually, the database is anonymized based on one-size-fits-all measures. Therefore, it is possible that several QIDs that a data user focuses on are all generalized, and the anonymized database has no value for the user. Moreover, if a database does not satisfy the eligibility requirement, we cannot anonymize it by existing methods. In this paper, we propose a new technique for l-diversity, which keeps QIDs unchanged and randomizes sensitive attributes of each individual so that data users can analyze it based on QIDs they focus on and does not require the eligibility requirement. Through mathematical analysis and simulations, we will prove that our proposed method for l-diversity can result in a better tradeoff between privacy and utility of the anonymized database.
Marching of the microlithography horses: electron, ion, and photon: past, present, and future (2007)

Microlithography patterning employs one of three media; electron, ion, and photon. They are in a way like horses, racing towards the mainstream. Some horses such as electrons run fast but repel each other. Ion beams behave like electron beams but are less developed. The photon beam is the undisputed workhorse, taking microlithography from the 5-&mgr;m minimum feature size to 32-nm half pitch. This paper examines the history of microlithography in pattern generation, proximity printing, and projection printing, then identifies the strong and weak points of each technology. In addition to ion-beam and e-beam lithography, the coverage of optical lithography spans the wavelength from 436 to 13.5 nm. Our learning from history helps us prevent mistakes in the future. In almost all cases, making or using the mask presents one of the limiting problems, no matter the type of beams or the replication method. Only the maskless method relieves us from mask-related problems. A way to overcome the low throughput handicap of maskless systems is to use multiple e-beam direct writing, whose imaging lens can be economically and compactly fabricated using MEMS techniques. In a way, the history of microlithography parallels that of aviation. Proximity printing is like the Wright-Brothers’ plane; 1X projection printing, single-engine propeller plane with unitized body; reduction step-and-repeat projection printing, multi-engine commercial airliner; scanners, jet airliners. Optical lithography has improved in many ways than just increasing NA and reducing wavelength just as the commercial airliners improving in many other areas than just the speed. The SST increased the speed of airliners by more than a factor of two just as optical resolution doubled with double exposures. EUV lithography with the wavelength reduced by an order of magnitude is similar to the space shuttle increasing its speed to more than 10 times that of the SST. Multiple-beam direct write systems are like helicopters. They do not need airports(masks) but we need a lot of beams to carry the same payload.
Human, mouse scRNA-seq and flow cytometry data in ischemic heart failure models predict immune cell activation signatures with altered endothelial cell cross talk (2022)

Abstract Chronic ischemic Heart Failure (HF) with reduced ejection fraction is marked by adverse remodelling and sustained inflammation. The effects of monocytes and T cells in early state immune responses after myocardial infarction are known, to date their role in progression and maintenance of chronic HF remains elusive. Single cell RNA sequencing of peripheral immune cells from healthy and HF donors revealed a significant increase of the antigen presentation (i.e. HLA-DRB5) and co-stimulatory molecules (i.e. ICAM-1) on monocytes, while the elevation of the T effector memory population in HF patients shows enhanced T cell activation. Subsequent flow cytometry validation in 55 healthy and 110 HF patients confirmed that HF derived monocytes have elevated levels of HLA-DRB5 predicts increased ICAM-1 and TREM-1 (p&amp;lt;0.0001 for both), indicating enhanced T cell activation capacity. In addition, the activated fraction of both CD4+ and CD8+ T cells, including central memory, effector memory and TEMRA cells, is significantly enriched in the HF patients (p&amp;lt;0.0001 for both) with reduction of the naïve T cells. T cell receptor (TCR) sequencing of age matched healthy and HF donors showed an increase in the relative TCR clonality in HF patients, indicating an expansion of the circulating T cells. ScRNA-seq murine myocardial infarction (MI) time course data (day (d) 0/1/3/7/14/28/48 post-MI), found a progressive increase in Th17 cells and activated CD8+ T cells in the cardiac tissue at d48 (2.8x-, and 2.7x-fold, respectively) relative to d0. The T cell imbalance was marked by loss of immunosuppressive markers such as Lef1 (p=2e-30) in T cell clusters primarily populated by d48 relative to d0. Mechanistically the downstream effects of the immune cell activation were analysed in the serum of HF patients, where increased levels of sICAM-1, IL-6 and TNFRI levels (1.75x-, 5.30x-, 2.63x-fold, respectively) could be detected. Furthermore, treatment of endothelial cells with the conditioning media from HF-immune cells induced capability to adhere with monocytes in a co-culture system but also decreased the checkpoint inhibitor molecule PD-L1, a known blocker of autoreactive T cells. These data link HF with enhanced monocyte and T cell activation as well as T cell clonal expansion, along with increased T cell numbers in mouse hearts post-MI. These data suggest HF is may drive impaired resolution of inflammation in cardiac tissue and facilitate adverse remodelling and cardiac damage. Further studies will assess the specific role of chronic monocyte and T cell activation in the progression of heart failure. Funding Acknowledgement Type of funding sources: Public grant(s) – National budget only. Main funding source(s): DFG -Deutsche ForschungsgemeinschaftDZHK -Deutsches Zentrum für Herzkreislauferkrankungen
ChemInform Abstract: The Influence of Oxide on the Electrodeposition of Niobium from Alkali Fluoride Melts. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Aberration corrected STEM of iron rhodium nanoislands (2014)

Iron-rhodium (FeRh) nanoislands of equiatomic composition have been analysed using scanning transmission electron microscopy (STEM) electron energy loss spec-troscopy(EELS) and high angle annular dark field (HAADF) techniques. Previous magne-tometry results have lead to a hypothesis that at room temperature the core of the islands are antiferromagnetic while the shell has a small ferromagnetic signal. The causes of this effect are most likely to be a difference in composition at the edges or a strain on the island that stretches the lattice and forces the ferromagnetic transition. The results find, at the film-substrate interface, an iron-rich layer ~ 5 Å thick that could play a key role in affecting the magnetostructural transition around the interfacial region and account for the room temperature ferromagnetism.
Effects of feed restriction and dry or soaked feed on growth of coho salmon &lt;i&gt;Oncorhynchus kisutch&lt;/i&gt; (2020)

ギンザケ養殖の給餌の省コスト・効率化を検討するために，従来の加水飽食給餌に対して，加水制限給餌および無加水飽食給餌で水槽飼育したギンザケの成長と増肉係数を比較した。乾燥重量ベースで飽食区の8-9割程度を与えた加水制限給餌では，終了時の平均体重が加水飽食給餌の0.95倍であったが統計学的な有意差はなかった。無加水飽食給餌区は加水飽食区と比べて摂餌量が少なく，終了時の平均体重は加水飽食給餌より有意に小さかった。
A review of bioanalytical quantitative methods for selected sphingosine 1‐phosphate receptor modulators (2017)

Sphingosine 1-phosphate (S1P<sub>1</sub> ) modulators provide an emerging therapeutic approach for various autoimmune disorders such as multiple sclerosis and psoriasis. Fingolimod is the first approved orally active, selective and potent drug of this class. Other drugs belonging to this class include siponimod, ponesimod, ceralifimod, amiselimod, CS-0777 and GSK2018682. However, owing to the high protein binding, polarity and zwitter-ionic nature of the phosphate metabolite of parent drugs, it becomes challenging to optimize the extraction method for this class of compounds. Although, there are individual published bioanalytical methods for the analysis of selected S1P<sub>1</sub> modulators to support preclinical and clinical drug development, no extensive review compiling all the bioanalytical methods for the important drugs in the class is available. Thus, we attempted to prepare a comprehensive review on various bioanalytical methods for selected S1P<sub>1</sub> modulators which will provide all the relevant bioanalytical information as required by bioanalytical researchers. This review focuses on the various liquid chromatography with tandem mass spectrometry methods that have been used to quantify S1P<sub>1</sub> modulators in various biological matrices. Extraction methods included liquid-liquid extraction, solid-phase extraction and one-step protein precipitation for extracting the analytes. This review captures key information regarding sample processing options and chromatographic/detection conditions.
Identification of a receptor binding site in the carboxyl terminus of human interleukin-6. (1992)

To identify a receptor binding site of human interleukin-6 (IL-6), we created a library of IL-6 variants with single amino acid substitutions in the last 15 residues (171-186) in the COOH terminus of IL-6.Twenty-seven IL-6 variants were tested for biological activity on a human hepatoma and a mouse hybridoma cell line.Most variants were additionally tested in a receptor binding assay using a human myeloma cell line.Several single amino acid substitutions in the COOH terminus of IL-6 were found to decrease biological activity significantly.This is especially seen in variants with amino acid substitutions that alter the postulated amphipathical a-helix structure between residues 178 and 183.The two highly conserved Arg residues at positions 180 and 183 seem to play a very important role in biological activity.The loss of biological activity in all inactive variants is completely par- alleled by a decrease of IL-6 receptor binding, as determined by competition binding experiments.One mutant (Leu171) displayed a higher activity on human cells and a higher binding affinity to the receptor and can be considered an IL-6 agonist.It is concluded that the amphipathical a-helix structure in the COOH terminus of IL-6 is critical for ligand receptor interaction.Furthermore, the region between residues Serl" and ArglS3 (Ser-Leu-Arg-Ala-X-Arg) is identified as a receptor binding site in the COOH terminus of human IL-6.Interleukin-6 (IL-6)' is a multifunctional cytokine that is produced by a variety of cells such as B-cells, T-cells, monocytes, fibroblasts, and endothelial cells (f6r review see Refs. 1, 2, and 3).IL-6 exerts several activities including terminal differentiation of B-cells (4), proliferation and differentiation of T-cells (5), regulation of the acute phase response (6), and growth regulation of epithelial cells (7).It also stimulates the
Tunicamycin induces ubiquitination and degradation of apolipoprotein B in HepG2 cells (2001)

Apolipoprotein (apo) B-100 is an essential component of atherogenic plasma lipoproteins. Previous studies have demonstrated that the production of apoB-100 is regulated largely by intracellular degradation at both the co-translational and post-translational levels and that proteasome-mediated and non-proteasome-mediated pathways are involved in this process. ApoB-100 is a glycoprotein. The present study was undertaken to address the question of whether the inhibition of N-linked glycosylation with tunicamycin would interfere with apoB-100 production. We demonstrated that the treatment of HepG2 cells with tunicamycin decreased the net production of apoB-100 by enhancing co-translational degradation of the protein. This effect of tunicamycin was partly prevented by lactacystin, a specific proteasome inhibitor. Because lactacystin only partly reversed the effects of tunicamycin on apoB biogenesis, tunicamycin seemed also to induce apoB co-translational degradation in HepG2 cells by one or more non-proteasomal pathways. Furthermore, tunicamycin increased apoB ubiquitination approx. 4-fold. The proportion of the newly synthesized apoB-100 that was secreted and incorporated into the nascent lipoprotein particles was unaffected by tunicamycin. Thus the tunicamycin-mediated inhibition of N-linked glycosylation interferes with the production of apoB-100 that is mediated by both proteasomal and non-proteasomal pathways.
Development of Chitosan Dermal Scaffold and its Characterization (2007)

This DOI is not currently attached to any metadata records. DOIs can’t actually ever be deleted (they’re persistent), but sometimes our members create DOIs in error. We do have a process to approximate deletion which we follow only in rare cases where the DOI has been genuinely created in error, and most crucially, if the DOI has never been published anywhere online or in print and never otherwise distributed to or communicated with anyone (authors, readers, reviewers, etc.