gebhart/patrepeval huggingface dataset:
Fuel Efficiency Analysis of Selected Hydraulic Hybrids in a Wheel Loader Application (2018)

There is a potential for significant improvement on fuel efficiency of many mobile machines by using hybrid technology as the Diesel engines are often driven at very inefficient operating points in these applications. The load generated by the working hydraulics of a mobile machine is often rapidly changing and contains high peak powers compared to the mean power required. This paper studies three different hydraulic hybrids in a wheel loader application. The study is based on a measured sand-loading Y-cycle. In addition to the hybrid systems, a load sensing proportional valve based reference machine and a modified machine based on independent metering valves are analyzed. All five system alternatives are analyzed systematically to enable a comparison of their fuel efficiency. The study shows that the fuel consumption of the machine can be decreased up to 28 % in such load cycle by using a suitable hydraulic hybrid system.
Chimie des matériaux hybrides (2018)

Enseignement Cours – Interfaces : chimie des matériaux, biologie, médecine (III) Introduction Cette année, nous avons consacré un ensemble de leçons, d’une part, à la description et l’analyse des connaissances actuelles sur les processus de biominéralisation et, d’autre part, à la présentation des avancées réalisées en science des matériaux via l’utilisation de virus pour la construction de matériaux hybrides fonctionnels. La biominéralisation est le processus biologique et physicochimique au...
Increasing Network Resiliency by Optimally Assigning Diverse Variants to Routing Nodes (2014)

Networks with homogeneous routing nodes are constantly at risk as any vulnerability found against a node could be used to compromise all nodes. Introducing diversity among nodes can be used to address this problem. With few variants, the choice of assignment of variants to nodes is critical to the overall network resiliency. We present the Diversity Assignment Problem (DAP), the assignment of variants to nodes in a network, and we show how to compute the optimal solution in medium-size networks. We also present a greedy approximation to DAP that scales well to large networks. Our solution shows that a high level of overall network resiliency can be obtained even from variants that are weak on their own. We provide a variation of our problem that matches the specific communication requirements of applications run over the network (e.g., Paxos and BFT). Also, we analyze the loss in resiliency when optimally assigning variants based on inaccurate information about compromises.
Mimicking Herpes Simplex Virus 1 and Herpes Simplex Virus 2 Mucosal Behavior in a Well-Characterized Human Genital Organ Culture (2014)

We developed and morphologically characterized a human genital mucosa explant model (endocervix and ectocervix/vagina) to mimic genital herpes infections caused by herpes simplex virus types 1 (HSV-1) and 2 (HSV-2). Subsequent analysis of HSV entry receptor expression throughout the menstrual cycle in genital tissues was performed, and the evolution of HSV-1/-2 mucosal spread over time was assessed. Nectin-1 and -2 were expressed in all tissues during the entire menstrual cycle. Herpesvirus entry mediator expression was limited mainly to some connective tissue cells. Both HSV-1 and HSV-2 exhibited a plaque-wise mucosal spread across the basement membrane and induced prominent epithelial syncytia.
[Anemia and chemotherapy of malignant hemopathies]. (2003)

Anemia is a frequent symptom encountered in hematological malignancies at diagnosis or in the course of the disease. Allogeneic transfusions were, until recently, the only treatment available and used only for severe anemia. Erythropoietin is currently an important alternative especially for treatment and even to prevent severe anemia. It has been assessed for the treatment of chemotherapy related anemia in NHL, myeloma and CLL with a significant reduction of blood transfusions and prevention of grade 3-4 anemia in 51% of patients. In myelodysplasia, the more effective regimen is the association of G-CSF and Epo. In the setting of allogeneic bone marrow transplantation, it reduces the time to red cell engraftment and probably the number of blood cell unit per patient in contrast with autologous stem cell transplant. All these studies assessed the efficacy of Epo in hematological malignancies but needs further trials including the assessment of the quality of life and economical parameters.
A Stem Cell Potency, Quality And Release (PQR) Assay For Umbilical Cord Blood That Is Compliant With Regulatory Guidelines (2010)

New guidelines and regulations in the U.S.A. and Europe will require that the cell potency of cellular and gene therapy products are determined prior to their intended use in the patient. Umbilical cord blood (UCB) is a cellular therapeutic product whose potency and release criteria will fall under these criteria. The present parameters of total nucleated cell (TNC) count, viability, CD34 and CFU not only fall significantly short of what would be required, but are used post-processing, pre-cryopreservation rather than post-thaw prior to transplantation. Furthermore, none of these tests determine stem cell “quality” or potency, which is a measure of stem cell engraftment potential (EP). The CFU assay, as used by the UCB community, measures the differentiation (not proliferation) of GM progenitors, which have no stem cell properties and therefore can only detect engraftment outcome, i.e. time to neutrophil engraftment, but not EP. An in vitro, instrument-based, ATP bioluminescence potency, quality and release (PQR) assay that can be fully validated for the intended use has been developed and tested. 24 UCB samples were tested for proliferation status (“quality”) and potential (potency) of 2 stem cell populations, 1 primitive (HPP-SP) and the other mature (CFC-GEMM), each at 3 cell doses, and the response compared to the same cell populations from a UCB reference standard. The results showed that the assay is >90% effective in predicting EP. Testing a single stem cell population (CFC-GEMM) can lead to a false interpretation, but a duel stem cell potency assay can provide greater predictive value for short- and long-term EP. Stem cell “quality” should also be determined using duel populations, since together with potency, acceptance limits for release criteria can be defined. The PQR assay is a powerful and predictive tool that, together with other assays, can provide the transplantation decision-maker with information that has, until now, not been possible.
Applying rhythm metrics to non-native spontaneous speech (2013)

This study investigates a variety of rhythm metrics on two corpora of non-native spontaneous speech and compares the nonnative distributions to values from a corpus of native speech.Several of the metrics are shown to differentiate well between native and non-native speakers and to also have moderate correlations with English proficiency scores that were assigned to the non-native speech.The metric that had the highest correlation with English proficiency scores (apart from speaking rate) was rPVIsyl (the raw Pairwise Variability Index for syllables), with r = -0.43.
Organometallic Complexes of Graphene (2013)

We demonstrate the organometallic hexahapto complexation of chromium with graphene, graphite and carbon nanotubes. All of these extended periodic pi-electron systems exhibit some degree of reactivity toward the reagents CrCO)6 and (eta6-benzene)Cr(CO)3, and we are able to demonstrate the formation of (eta6-rene)Cr(CO)3 or (eta6-arene)2Cr, where arene = single-walled carbon nanotubes (SWNT), exfoliated graphene (XG), epitaxial graphene (EG) and highly-oriented pyrolytic graphite (HOPG). We find that the SWNTs are the least reactive presumably as a result of the effect of curvature on the formation of the hexahapto bond; in the case of HOPG, (eta6-HOPG)Cr(CO)3 was isolated while the exfoliated graphene samples were found to give both (eta6-graphene)2Cr, and (eta6-graphene)Cr(CO)3 structures. We report simple and efficient routes for the mild decomplexation of the graphene-chromium complexes which appears to restore the original pristine graphene state. This study represents the first example of the use of graphene as a ligand and is expected to expand the scope of graphene chemistry in connection with the application of this material in organometallic catalysis.
Supplementary Table 1 from Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth (2023)

Supplementary Table 1 from Loss of Cannabinoid Receptor 1 Accelerates Intestinal Tumor Growth
Self-consistent compact electrical and thermal modeling of power devices including package and heat-sink (2010)

This paper shows a hybrid approach to electro-thermal modeling of power device assemblies that aims at bridging the gap between compact models amenable to insertion into circuit simulators and physical models (such as finite-element ones) of the three-dimensional heat flow in the system. We self-consistently couple a standard analytical description of the temperature-dependent electrical behavior of a power MOSFET with a lumped-element thermal network representing the die - package - heat-sink assembly and convective boundary conditions. This lumped-element network is built by partitioning the system into elementary building blocks and assigning to the thermal resistances values determined by the geometrical dimensions and material thermal conductivities. The results of the lumped-element model are shown to be in good agreement with measurements and three-dimensional finite-element simulations.
Experimental spectrum sensor testbed for constructing indoor Radio Environmental Maps (2011)

In this paper we describe an experimental testbed to empirically study the construction of Radio Environmental Maps (REMs) in indoor environments. The testbed allows investigating the characteristics and modeling of the radio environment for indoor scenarios. The deployed system is a network of over 80 heterogeneous wireless spectrum sensors with significantly different measurement capabilities in an office building consisting of multiple rooms. As application examples we consider two scenarios, one illustrating the indoor propagation conditions and another showing temporal aspects of primary node activities as observed by sensing devices. The observed phenomena strongly indicate that development of general radio environment map solutions for indoor use are extremely challenging, unless heterogeneity of spectrum sensors and non-linearity of propagation conditions is considered. Our measurement results advocate dynamic construction of REMs instead of static solutions. We strongly believe that the deployed testbed and obtained experimental data can further facilitate research in the area of REMs.
Palatability, reactogenicity and immunogenicity of engineered live oral cholera vaccine CVD 103-HgR in Chilean infants and toddlers (1999)

Single dose oral CVD 103-HgR is well-tolerated and immunogenic in infants even when a partial dose is ingested. The buffered vaccine cocktail that is readily imbibed by older children is not appealing to young infants, and improved vaccine formulations and delivery vehicles for immunizing infants must be sought.
Friction Reducing Properties and Stability of Epoxidized Oleochemicals (2008)

Abstract The properties of epoxidized oleochemical methyl esters were studied. Epoxidized soybean oil, epoxidized methyl oleate, epoxidized methyl linoleate, and epoxidized methyl linolenate were compared with each other and with similar series of unmodified olefins. Several interesting trends were uncovered including: epoxidation of olefinic materials improves their oxidative stability, epoxidation of oleochemicals increases their adsorption to metal surfaces, and epoxidation has a deleterious effect on the pour point and viscosity index of the oleochemicals. In addition, a simple qualitative method where lubrication performance can be compared by examination of wear scars generated by ball‐on‐disk friction measurement under a simple optical microscope is reported.
NONPHOTOCHEMICAL HOLE BURNING OF THE B800‐B850 ANTENNA COMPLEX OF Rhodopseudomonas acidophila (1993)

Abstract Detailed burn wavelength‐dependent hole‐burning studies of the title complex have been performed. The zero‐phonon hole (ZPH) widths for B800 at 4.2 K are 6.0 ± 0.3 cm and are discussed in terms of B80O‐B850 and B800‐B800 energy transfer. The B800* lifetime is 1.8 ± 0.2 ps. The site inhomogeneous broadening (r,) of B800 is 240 cm −1 . The B850 (located at 864 nm at 4.2 K) hole spectra reveal that B850 suffers from significant homogeneous broadening, which is attributed to unit cell exciton level structure and ultrafast interexciton level relaxation. Novel ZPH action spectra lead to the resolution of a minor component at 885 nm, which is the analogue of B870 of Rhodobacter sphaeroides previously assigned as the lowest exciton level of the B850 exciton band. The B870 ZPH width of 2.0 ± 0.2 cm −1 for Rhodopseudomonas acidophila leads to a total dephasing time of 5.3 ps, which is attributed to exciton scattering that stems from the energetic inequivalence of neighboring B850 unit cells.
Optimization Method for Inspection Scheduling of Power Distribution Facilities (2013)

Power distribution companies must establish an optimal maintenance schedule that balances reliability and efficiency of a number of widely scattered facilities. Conventionally, Japanese power utilities divide their distribution areas into multiple inspection areas, and they maintain high reliability by periodically inspecting each area. Such a time-based maintenance scheme is generally inefficient. This paper proposes a method for optimizing inspection schedules of Japanese distribution facilities. An inspection interval model is presented that estimates the inspection interval for each facility by using past inspection data. Moreover, an algorithm to minimize the inspection cost based on an estimated interval is proposed. The algorithm can effectively determine the optimal combination of two inspection schemes, an area inspection, and an individual inspection. Evaluations of results with test data show that the algorithm reduces the inspection cost by at least 14%, retaining system reliability. The proposed method results in a more effective inspection schedule.
A Novel Technique for Generating and Observing Chemiluminescence in a Biological Setting (2017)

Intraoperative imaging techniques have the potential to make surgical interventions safer and more effective; for these reasons, such techniques are quickly moving into the operating room. Here, we present a new approach that utilizes a technique not yet explored for intraoperative imaging: chemiluminescent imaging. This method employs a ruthenium-based chemiluminescent reporter along with a custom-built nebulizing system to produce ex vivo or in vivo images with high signal-to-noise ratios. The ruthenium-based reporter produces light following exposure to an aqueous oxidizing solution and re-reduction within the surrounding tissue. This method has allowed us to detect reporter concentrations as low as 6.9 pmol/cm<sup>2</sup>. In this work, we present a visual guide to our proof-of-concept in vivo studies involving subdermal and intravenous injections in mice. The results suggest that this technology is a promising candidate for further preclinical research and might ultimately become a useful tool in the operating room.
Solution-Processed Air-Stable Mesoscopic Selenium Solar Cells (2016)

Crystalline selenium (c-Se) is a direct band gap semiconductor and has been developed for detector applications for more than 30 years. While most advances have been made using vacuum deposition processes, it remains a challenge to prepare efficient c-Se devices directly from solution. We demonstrate a simple solution process leading to uniform and high-crystallinity selenium films under ambient conditions. A combination of ethylenediamine (EDA) and hydrazine solvents was found to be effective in dissolving selenium powder and forming highly concentrated solutions. These can be used to infiltrate a mesoporous titanium dioxide layer and form a smooth and pinhole-free capping overlayer. Efficient light-induced charge injection from the crystalline selenium to TiO2 was observed using transient absorption spectroscopy. A small amount of EDA addition in the hydrazine solution was found to improve the film coverage significantly, and on the basis of the finding, we are able to achieve up to 3.52% power conversion efficiency solar cells with a fill factor of 57%. These results provide a method to control the crystalline selenium film and represent significant progress in developing low-cost selenium-based solar cells.
Apoptotic death induced by TMZ and MX is due to apoptotic signals emanating from mitochondria DNA damage (2004)

1540 The importance of the mitochondria in DNA damage agent induced apoptosis has become increasingly apparent, due to the fact that mitochondrial DNA is a critical target for damage from chemicals and oxidants and they are the central regulator of apoptosis. We have previously reported that methoxyamine potentiate cytotoxicity of temozolomide through the its ability to bind AP sites produced after removal of TMZ-induced abnormal bases, such as N7mG or N3mA, by DNA methylpurine glycosylase, leading to interruption of BER. In this study, we examined the impact of mitochondrial DNA damage on cell killing effect of TMZ and MX by measuring the formation N7mG DNA adducts and AP sites that are the DNA damages for BER. We also assayed the reduction of AP sites by MX that indicates the blockage of BER. N7mG DNA adducts were detected by HPLC in both mtDNA and nuclear DNA respectively after cells (colon cancer cell lines: HCT116 and SW480) were treated with TMZ (0-1500 μM) and with/without MX (12 mM) for 4 hr. The levels of N7mG DNA adducts were increased proportionally with the concentration of TMZ, however, the levels of N7mG were 3-5 fold higher in mtDNA than that in nuclear DNA. The combination of TMZ with MX did not affect the formation of N7mG adducts. AP site assay by ARP, which has similar reactivity to MX to bind AP sites, showed that MX reduced AP sites by 3-fold of AP sites generated by TMZ alone in either mtDNA and nuclear DNA. These data suggest that TMZ induces high levels of mtDNA damages and MX is able to blocking BER in mitochondria. Thus, mtDNA is the target for TMZ and MX. Decreased expression of Bcl-2 was observed 24 h after treatment with TMZ and MX, indicating the onset of apoptotic death mediated by Bcl-2, however, we suggest that the apoptotic signals are emanating from mitochondria DNA damages.
Clinicopathological significance of circadian rhythm‐related gene expression levels in patients with epithelial ovarian cancer (2008)

Abstract Objective. Recent studies implicate circadian genes in the regulation of cell cycle, apoptosis, and cell proliferation at a molecular level. These genesey affect cancer incidence, prognosis, and chemosensitivity. In this study, we measured the expression levels of clock genes and correlated their expression levels with clinicopathological parameters in epithelial ovarian cancer. Methods. The expression levels of core clock genes, per1, per2, per3, cry1, cry2, Bmal1, clock, and CKIɛ were quantified by real‐time quantitative Reverse transcription‐polymerase chain reaction in 83 ovarian cancer tissues and 11 normal ovarian tissues. Results. The expression levels of per1, per2, cry2, clock, CKIɛ in ovarian cancers were significantly lower than those in normal ovaries. In contrast, cry1 expression was highest among the eight examined clock genes, followed by per3 and Bmal1. Cry1 expression was much higher in cancer than that in normal ovaries. Localized circadian gene expression was determined in cancer cells by in situ hybridization analysis. Cry1 expression was significantly reduced in mucinous and grade 3 tumors. Bmal1 expression was also significantly reduced in mucinous adenocarcinomas as compared to other histologies. In a multivariate analysis, the combination of low cry1 expression and low Bmal1 expression was an independent prognostic factor, as well as stage and histological subtype. Conclusions. The antiphase expression of cry1 and Bmal1 may be preserved in ovarian cancers. The combination of cry1 and Bmal1 expression might become a possible prognostic marker in epithelial ovarian cancer.
Illuminant and Device Invariance Using Histogram Equalisation (2003)

In this paper we propose a new device and illumination invariant image representation based on an existing grey-scale image enhancement technique: histogram equalisation. Our method is based on the premise that the rank ordering of sensor responses is preserved across a change in imaging conditions (lighting or device). We set out the theoretical conditions under which this premise is true and we present empirical evidence which demonstrates that rank ordering is maintained in practice for a wide range of illuminants and imaging devices. We then show how we can exploit this rank invariance using histogram equalisation to derive an invariant image representation. Device and illuminant invariance are important in many imaging applications and in this paper we demonstrate the practical benefits of our new method in one such situation: the problem of image retrieval. We show that using the new invariant image representation to index into a database of images taken with a variety of devices under different lights provides very good indexing performance across all imaging conditions.
Damage modeling for Taylor impact simulations (2006)

G. I. Taylor showed that dynamic material properties could be deduced from the impact of a projectile against a rigid boundary. The Taylor anvil test became very useful with the advent of numerical simulations and has been used to infer and/or to validate material constitutive constants. A new experimental facility has been developed to conduct Taylor anvil impacts to support validation of constitutive constants used in simulations. Typically, numerical simulations are conducted assuming 2-D cylindrical symmetry, but such computations cannot hope to capture the damage observed in higher velocity experiments. A computational study was initiated to examine the ability to simulate damage and subsequent deformation of the Taylor specimens. Three-dimensional simulations, using the Johnson-Cook damage model, were conducted with the nonlinear Eulerian wavecode CTH. The results of the simulations are compared to experimental deformations of 6061-T6 aluminum specimens as a function of impact velocity, and conclusions regarding the ability to simulate fracture and reproduce the observed deformations are summarized.
Online Deep Neural Network for Optimization in Wireless Communications (2022)

Recently, deep neural network (DNN) has been widely adopted in the design of intelligent communication systems thanks to its strong learning ability and low testing complexity. However, most offline DNN-based methods suffer from unsatisfactory performance, limited generalization ability, and poor interpretability. In this letter, we propose an online DNN-based approach to solve general optimization problems in wireless communications, where a dedicated DNN is trained for each data sample. By treating the optimization variables and the objective function as network parameters and loss function, respectively, the optimization problem can be solved through network training. Due to the online optimization nature, the proposed approach manifests strong generalization ability and interpretability, while its superior performance is demonstrated through a practical example of joint beamforming in intelligent reflecting surface (IRS)-aided multi-user multiple-input multiple-output (MIMO) systems.