gebhart/patrepeval huggingface dataset:
Efficient nonlinear skin simulation for multi-finger tactile rendering (2016)

Recent advances in tactile rendering span, among others, wearable cutaneous interfaces, tactile rendering algorithms, or nonlinear soft skin models. However, the adoption of these advances for multi-finger tactile rendering of dexterous grasping and manipulation is hampered by the computational cost incurred with nonlinear skin models when applied to the full hand. We have observed that classic constrained dynamics solvers, typically designed for contact mechanics, fail to perform efficiently on deformation constraints of nonlinear skin models. In this paper, we propose a novel constrained dynamics solver designed to perform well with highly nonlinear deformation constraints. In practice, we achieve more than 10× speed-up over previous approaches, and as a result we enable multi-finger tactile rendering of manipulation actions that capture the nonlinearity of skin.
In Situ Raman Characterization of SOFC Materials in Operational Conditions: A Doped Ceria Study (2020)

The particular operational conditions of electrochemical cells make the simultaneous characterization of both structural and transport properties challenging. The rapidity and flexibility of the acquisition of Raman spectra places this technique as a good candidate to measure operating properties and changes. Raman spectroscopy has been applied to well-known lanthanide ceria materials and the structural dependence on the dopant has been extracted. The evolution of Pr-doped ceria with temperature has been recorded by means of a commercial cell showing a clear increment in oxygen vacancies concentration. To elucidate the changes undergone by the electrolyte or membrane material in cell operation, the detailed construction of a homemade Raman cell is reported. The cell can be electrified, sealed and different gases can be fed into the cell chambers, so that the material behavior in the reaction surface and species evolved can be tracked. The results show that the Raman technique is a feasible and rather simple experimental option for operating characterization of solid-state electrochemical cell materials, although the treatment of the extracted data is not straightforward.
Interstitial Lung Disease in Japanese Patients with Lung Cancer (2008)

ILD was relatively common in these Japanese patients with NSCLC during therapy with gefitinib or chemotherapy, being higher in the older, smoking patient with preexisting ILD or poor performance status. The risk of developing ILD was higher with gefitinib than chemotherapy, mainly in the first 4 weeks.
A heuristic approach for solving decentralized-POMDP (2002)

Defining the behaviour of a set of situated agents, such that a collaborative problem can be solved is a key issue in multi-agent systems. In this paper, we formulate this problem from the decision theoretic perspective using the framework of Decentralized Partially Observable Markov Decision Processes (DEC-POMDP). Formulating the coordination problem in this way provides a formal foundation for study of cooperation activities. But, as it has been recently shown solving DEC-POMDP is NEXP-complete and thus it is not a realistic approach for the design of agent cooperation policies. However, we demonstrate in this paper that it is not completely desperate. Indeed, we propose an heuristic approach for solving DEC-POMDP when agents are memory-less and when the global reward function can be broken up into a sum of local reward functions. We demonstrate experimentally on an example (the so-called pursuit problem) that this heuristic is efficient within a few iteration steps.
Mechanosensitive ACKR4 scavenges CCR7 chemokines to facilitate T cell de-adhesion and passive transport by flow in inflamed afferent lymphatics (2022)

T cell migration via afferent lymphatics to draining lymph nodes (dLNs) depends on expression of CCR7 in T cells and CCL21 in the lymphatic vasculature. Once T cells have entered lymphatic capillaries, they slowly migrate into contracting collecting vessels. Here, lymph flow picks up, inducing T cell detachment and rapid transport to the dLNs. We find that the atypical chemokine receptor 4 (ACKR4), which binds and internalizes CCL19 and CCL21, is induced by lymph flow in endothelial cells lining lymphatic collectors, enabling them to scavenge these chemokines. In the absence of ACKR4, migration of T cells to dLNs in TPA-induced inflammation is significantly reduced. While entry into capillaries is not impaired, T cells accumulate in the ACKR4-deficient dermal collecting vessel segments. Overall, our findings identify an ACKR4-mediated mechanism by which lymphatic collectors facilitate the detachment of lymph-borne T cells in inflammation and their transition from crawling to free-flow toward the dLNs.
Colorimetric iodide detection in water: a new photo-activated indicator system (2011)

AbstractThe photo-induced conversion of iodide to triiodide is an iodide-specific reaction that has now been optimised to produce a reaction-based indicator system for the iodide anion that functions in water. The observed signal (based on the triiodide anions produced upon photo-irradiation) was further amplified with starch (amylase) to produce a signal that can be detected easily by the naked eye. This approach not only allows for the yes/no discrimination of I− over other anions, it also permits detection of the iodide anion at concentrations of ≥ 30 μM by simple visual means, as well as in iodised table salt.Keywords: iodide indicatorsensorchemosensor AcknowledgementThis work was supported by Inha University Research Grant (Inha-39246-1).
Safety and efficacy of the selective progesterone receptor modulator asoprisnil for heavy menstrual bleeding with uterine fibroids: pooled analysis of two 12-month, placebo-controlled, randomized trials (2019)

12 September 2002; 6 September 2002.
Open-Source High-Fidelity Aggregate Composite Load Models of Emerging Load Behaviors for Large-Sale Analysis (2020)

The goal of this project is to accurately model the dynamic loads for power system planning and operation and to address the challenges inherent in such modeling. Existing load models are inadequate to handle the increasing proliferation of residential air conditioner loads and distributed energy resources, the emerging trends of price-responsive demand, and the growing importance of protective devices in equipment and buildings. A need has emerged to develop a fundamentally new class of load models and next-generation data tools. This work proposes to develop a set of regional–level, scalable open source load models and tools, including large-scale aggregate load protection, concept of price responsive demand, advanced load composition data, next-generation load model data tools, and advanced composite load model calibration and validation frameworks to address new challenges in the representation of next-generation load models.
Intramammary Application of Non-Methylated-CpG Oligodeoxynucleotides (CpG) Inhibits both Local and Systemic Mammary Carcinogenesis in Female BALB/c Her-2/neu Transgenic Mice (2008)

CpG are powerful drugs activating the innate immune system. In this study, the ability of their intramammary administration in impeding the devastating progression of carcinogenesis in all the mammary glands of female BALB/c mice transgenic for the rat neu transforming oncogene was assessed. Starting when in situ carcinomas were scattered over all their mammary glands (week 10), mice received CpG injections in the stroma of the fourth left gland. Local neoplastic progression was inhibited by six monthly administrations. CpG not only delayed the onset of carcinomas in the injected gland, but also hampered their progression. Extended latency was observed for tumors in glands both close to and far from the injection site. When the experiment ended (week 45), no tumors were palpable in 67% of the injected glands and a markedly impaired tumor growth was evident in the others. An impressive local infiltrate of CD11b(+) cells with the morphologic features of macrophages, plasma cells, B220(+) B cells, and CD4(+) and CD8(+) T cells was quickly recruited to the CpG-treated glands. High quantities of IFN-gamma producing cells were only present in the ipsilateral axillary draining lymph nodes of the treated glands. Enhanced natural killer (NK) lytic activity was also detected in the spleens. Inhibition of progression was weaker when only four injections were given, and abolished by in vivo depletion of NK cells. CpG monotherapy is thus effective in an aggressive model of autochthonous cancer. The results strongly support the administration of CpG as a local monotherapy of multiple invasive microscopic lesions.
Detection of dynamic substrate binding using MRI (2017)

Magnetic Resonance Imaging (MRI) is rarely used for molecular binding studies and never without synthetic metallic labels. We designed an MRI approach that can specifically detect the binding of natural substrates (i.e. no chemical labels). To accomplish such detection of substrate-target interaction only, we exploit (i) the narrow resonance of aliphatic protons in free substrate for selective radio-frequency (RF) labeling and, (ii) the process of immobilisation upon binding to a solid-like target for fast magnetic transfer of this label over protons in the target backbone. This cascade of events is ultimately detected with MRI using magnetic interaction between target and water protons. We prove this principle using caffeine as a substrate in vitro and then apply it in vivo in the mouse brain. The combined effects of continuous labeling (label pumping), dynamic reversible binding, and water detection was found to enhance the detection sensitivity by about two to three orders of magnitude.
Effect of proximal gastric vagotomy on human gastric blood flow evaluated by endoscopic laser doppler flowmetry (1988)

Abstract The effect of proximal gastric vagotomy (PGV) on gastric blood flow has been evaluated endoscopically by laser Doppler flowmetry (LDF) in 12 patients with duodenal ulcer. The gastric wall circulation was examined at 7 defined positions in all subjects prior to surgery, 1 week postoperatively, and after 3 months. For comparison, 21 healthy volunteers were also examined by LDF . In all the investigated areas of the stomach, the blood flow values were lower in the unoperated duodenal ulcer patients than in the controls. In both groups, the blood circulation was significantly lower at the lesser curvature than at the greater curvature . Seven days after PGV, the blood flow was reduced 30% in the devascularized part of the lesser curvature. After 3 months, the flow values were similar to the preoperative ones. The gastric acid secretion was significantly reduced at 3 months . Postoperatively, one patient developed a gastric ulcer in the dissected area of the lesser curvature. This patient had lower flow values along the lesser curvature than the other patients after 7 days . The results of this study show that PGV leads to a temporary reduction of blood flow at the lesser curvature. This regional decrease in blood flow is probably not an important factor for the reduced acid secretion measured after PGV .
Allelic variation of the <i>Tas1r3</i> taste receptor gene selectively affects taste responses to sweeteners: evidence from 129.B6-<i>Tas1r3</i> congenic mice (2007)

The Tas1r3 gene encodes the T1R3 receptor protein, which is involved in sweet taste transduction. To characterize ligand specificity of the T1R3 receptor and the genetic architecture of sweet taste responsiveness, we analyzed taste responses of 129.B6-Tas1r3 congenic mice to a variety of chemically diverse sweeteners and glucose polymers with three different measures: consumption in 48-h two-bottle preference tests, initial licking responses, and responses of the chorda tympani nerve. The results were generally consistent across the three measures. Allelic variation of the Tas1r3 gene influenced taste responsiveness to nonnutritive sweeteners (saccharin, acesulfame-K, sucralose, SC-45647), sugars (sucrose, maltose, glucose, fructose), sugar alcohols (erythritol, sorbitol), and some amino acids (D-tryptophan, D-phenylalanine, L-proline). Tas1r3 genotype did not affect taste responses to several sweet-tasting amino acids (L-glutamine, L-threonine, L-alanine, glycine), glucose polymers (Polycose, maltooligosaccharide), and nonsweet NaCl, HCl, quinine, monosodium glutamate, and inosine 5'-monophosphate. Thus Tas1r3 polymorphisms affect taste responses to many nutritive and nonnutritive sweeteners (all of which must interact with a taste receptor involving T1R3), but not to all carbohydrates and amino acids. In addition, we found that the genetic architecture of sweet taste responsiveness changes depending on the measure of taste response and the intensity of the sweet taste stimulus. Variation in the T1R3 receptor influenced peripheral taste responsiveness over a wide range of sweetener concentrations, but behavioral responses to higher concentrations of some sweeteners increasingly depended on mechanisms that could override input from the peripheral taste system.
Ion Selective Permeation Through Cellulose Acetate Membranes in Forward Osmosis (2013)

Solute–solute interactions can have a dramatic impact on the permeation of solutes through dense polymeric membranes. In particular, understanding how solute–solute interactions can affect the design of osmotically driven membrane processes (ODMPs) is critical to the successful development of these emerging water treatment and energy generation processes. In this work, we investigate the influence that solute–solute interactions have on nitrate permeation through an asymmetric cellulose acetate forward osmosis membrane. A series of experiments that included systematic modifications to the cation paired with nitrate, the identity of the draw solute, and the solution pH were conducted. These experiments reveal that in the unique operating geometry of ODMPs, where solute containing solutions are present on both sides of the membrane, nitrate fluxes are significantly higher (>15 times in some cases) than predicted by existing models for solute permeation in ODMPs. The identity of the cation paired with nitrate influences the flux of nitrate; the identity of the cation in the draw solution does not affect the flux of nitrate; however, the identity of the anion in the draw solution has the most significant impact on the flux of nitrate. These results suggest that an ion exchange mechanism, which allows nitrate to switch rapidly with anions from the draw solution, is present when cellulose acetate based membranes are used in ODMPs.
Figure S8 from Theranostic Targeting of CUB Domain–Containing Protein 1 (CDCP1) in Multiple Subtypes of Bladder Cancer (2023)

&lt;p&gt;CDCP1 mRNA is not correlated NECTIN4 or TROP2 mRNA, related to Figure 2C. Spearman correlation analyses were performed between CDCP1 and NECTIN4 or TROP2 for the Seiler, Sjodahl 2017, and Sjodahl 2012 datasets, with p values and correlation coefficients shown. Points are colored by consensus subtype as in Figure 1.&lt;/p&gt;
Near-unity broadband infrared absorption in a graphene-black phosphorus bimodal triple-layer structure (2023)

It is well known that both graphene and monolayer black phosphorus (BP) can excite and generate surface plasmonic resonances in the infrared spectrum, providing suitable conditions for strong light-matter interactions. To take full advantage of this benefit, a three-layered infrared absorbing structure with broadband absorption effect based on a hybrid graphene-BP metamaterial was developed. Using numerical research methods, the absorption effect of the structure could be well modulated by adjusting the geometrical parameters of the structure and the doping levels of graphene and BP. In addition, the sensitivity of the structure to the angle of incidence is also investigated. By optimizing the previous parameters, the structure achieves an absorption of more than 87.5% in the wavelength range from 10.1 to 24.5 um and a maximum absorption of 99.97%. The proposed broadband infrared structure could have many potential applications in infrared sensing, bio-imaging and environmental monitoring.
X-ray Reflectivity as a Metrology to Characterize Pores in Low-k Dielectric Films (2004)

A form of porosimetry is described whereby X-ray reflectivity is a highly sensitive metrology to quantify the capillary condensation of toluene vapor inside porous low-K dielectric films on a silicon substrate. As the partial pressure of the toluene environment over the film increases, capillary condensation occurs in progressively larger pores. This results in an appreciable increase in the electron density of the film. By monitoring the changes in the critical angle for total X-ray reflectance, one can directly calculate the average electron density, and therefore the toluene uptake. By invoking traditional porosimetry absorption/desorption procedures, characterstics such as porosity and the distribution of pore sizes can be extracted. To illustrate, the porosity in a number of low-K films are characterized using this methodology.
The Georgia Memory Net: Implementation of a statewide program to diagnose and treat Alzheimer's disease and related dementias (2022)

GMN is an innovative care model to improve access to accurate and timely diagnosis in patients with memory loss. GMN may help improve the quality of life for patients and families through preventive and early care.
ChemInform Abstract: A Pharmacological Review of Competitive Inhibitors and Substrates of High‐Affinity, Sodium‐Dependent Glutamate Transport in the Central Nervous System (1999)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Detection of 4-point Bend Induced Micro-cracks in CFRP Laminates via Coda Wave NDE (2016)

Although coda wave NDE has been shown to have some sensitivity to realistic damage in concrete structures, the technique’s capability for detecting micro-cracks in fibrous composite materials has yet to be evaluated. This paper reports on the first investigation of realistic damage, specifically micro-cracks, in fibrous composite materials using coda wave differential signal features. Micro-cracks were generated in CFRP samples using the 4-point bending configuration shown in Fig. 1. The damage was monitored during loading with Acoustic Emission, and the loading was stopped after each significant damage event. The damage was then examined with coda wave NDE, immersion UT, and micrographs. This work demonstrates the capability of coda waves to detect and monitor micro-cracks in CFRP laminates. Coda wave sensitivity, repeatability, and reproducibility is presented and discussed.\nThis material is based on work supported by the NSF Industry/University Cooperative Research Program of the Center for Nondestructive Evaluation at Iowa State University.
ORCHESTRA: Optimizable RF Converged Hardware Expression of a Scalable Transmit/Receive Architecture (2018)

The need for disruptive advances in warfighter capability, upgradability, and utilization drives sensor systems toward convergent RF functionality with shared resources. The reliance of modern federated RF systems on redundant hardware leads to underutilization and inefficient use of SWaP-C. In pursuit of affordable solutions to this shortfall, converged RF and heterogeneous digital signal processing combine with existing open standard system-of-systems platform concepts to enable the next generation of platform and mission capability, through a true digital array interface to the RF environment.
Climate change and multitrophic interactions in soil: the primacy of plants and functional domains (2012)

Abstract Soil multitrophic interactions transfer energy from plants as the predominant primary producer to communities of organisms that occupy different positions in the food chain and are linked by multiple ecological networks, which is the soil food web. Soil food web sequesters carbon, cycles nutrients, maintains soil health to suppress pathogens, helps plants tolerate abiotic and biotic stress, and maintains ecosystem resilience and sustainability. Understanding the influence of climate change on soil multitrophic interactions is necessary to maintain these essential ecosystem services. But summarising this influence is a daunting task due to a paucity of knowledge and a lack of clarity on the ecological networks that constitute these interactions. The scant literature is fragmented along disciplinary lines, often reporting inconsistent findings that are context and scale‐dependent. We argue for the differentiation of soil multitrophic interactions along functional and spatial domains to capture cross‐disciplinary knowledge and mechanistically link all ecological networks to reproduce full functionalities of the soil food web. Distinct from litter mediated interactions in detritosphere or elsewhere in the soil, the proposed ‘pathogen suppression’ and ‘stress tolerance’ interactions operate in the rhizosphere. A review of the literature suggests that climate change will influence the relative importance, frequency and composition of functional groups, their trophic interactions and processes controlling these interactions. Specific climate change factors generally have a beneficial influence on pathogen suppression and stress tolerance, but findings on the overall soil food web are inconsistent due to a high level of uncertainty. In addition to an overall improvement in the understanding of soil multitrophic interactions using empirical and modelling approaches, we recommend linking biodiversity to function, understanding influence of combinations of climatic factors on multitrophic interactions and the evolutionary ecology of multitrophic interactions in a changing climate as areas that deserve most attention.
Levels and Determinants of Inflammatory Biomarkers in a Swiss Population-Based Sample (CoLaus Study) (2011)

Population-based levels of several cytokines were established. Increased age and BMI, and to a lesser degree sex and smoking, significantly and differentially impact cytokine levels, while leisure-time physical activity has little effect.
Affinity Labeling of Membrane Receptors Using Tissue-Penetrating Radiations (2013)

Photoaffinity labeling, a useful in vivo biochemical tool, is limited when applied in vivo because of the poor tissue penetration by ultraviolet (UV) photons. This study investigates affinity labeling using tissue-penetrating radiation to overcome the tissue attenuation and irreversibly label membrane receptor proteins. Using X-ray (115 kVp) at low doses (<50 cGy or Rad), specific and irreversible binding was found on striatal dopamine transporters with 3 photoaffinity ligands for dopamine transporters, to different extents. Upon X-ray exposure (115 kVp), RTI-38 and RTI-78 ligands showed irreversible and specific binding to the dopamine transporter similar to those seen with UV exposure under other conditions. Similarly, gamma rays at higher energy (662 keV) also affect irreversible binding of photoreactive ligands to peripheral benzodiazepine receptors (by PK14105) and to the dopamine (D2) membrane receptors (by azidoclebopride), respectively. This study reports that X-ray and gamma rays induced affinity labeling of membrane receptors in a manner similar to UV with photoreactive ligands of the dopamine transporter, D2 dopamine receptor (D2R), and peripheral benzodiazepine receptor (PBDZR). It may provide specific noninvasive irreversible block or stimulation of a receptor using tissue-penetrating radiation targeting selected anatomic sites.
Warfarin Use and Risk for Osteoporosis in Elderly Women (1998)

In this population, warfarin use did not decrease bone mineral density or increase fracture rates.
Hydrogen and Fuel Cells. Fundamentals, Technologies and Applications. Edited by Detlev Stolten. (2011)

Wiley-VCH, Weinheim 2010. 878 pp., hardcover, € 249.00.—ISBN 978-3527327119