gebhart/patrepeval huggingface dataset:
ESTUDO DO EXTRATO DE Piper hispidinervum C. DR. USANDO DIÓXIDO DE CARBONO SUPERCRÍTICO (2018)

O objetivo deste trabalho consistiu em avaliar a influência das condições operacionais no processo de extração supercrítica com dióxido de carbono (CO2) para a obtenção de compostos bioativos de Piper hispidinervum. Foram usadas as seguintes condições operacionais: 80 bar com 40°C, 100 bar com 40°C e 200 bar com 40°C. A média dos rendimentos obtidos foram: 2,158%, 2,606% e 2,989%, respectivamente. O composto obtido como majoritário para as três condições operacionais foi o safrol. A variação das condições operacionais não causou efeito seletivo na extração dos biocompostos.
supplemental figure 2 from Phase I/II Study of Metastatic Melanoma Patients Treated with Nivolumab Who Had Progressed after Ipilimumab (2023)

&lt;p&gt;Suppression of T-cell proliferation by MDSC&lt;/p&gt;
Polarization-independent phase modulation of a homeotropic liquid crystal gel (2005)

A homeotropic liquid crystal (LC) gel with submicron domain size is fabricated and its phase-only modulation property evaluated. The LC gel is highly transparent in the voltage-off state and exhibits pure phase modulation before light scattering occurs. Compared to a nanosized polymer-dispersed liquid crystal (nano-PDLC), our gel possesses a larger phase change but at a lower operating voltage because of a higher LC concentration. Similar to a nano-PDLC, our gel also exhibit submillisecond response time, hysteresis-free, and polarization-independent phase change.
APNG as a prognostic marker in patients with glioblastoma (2017)

Using two different assays combined with quantitative image analysis excluding non-tumour cells, APNG was an independent prognostic factor among patients with a methylated MGMT promoter. We expect that APNG qIHC can potentially identify GBM patients who will not benefit from treatment with temozolomide.
Altered Ability of the Liver to Produce Glucose Following a Period of Glucagon Deficiency (1981)

It is known that the effectiveness of a physiologic increment in glucagon to stimulate glucose production wanes with time even when counterregulatory insulin secretion is prevented. The aim of the present study was to establish whether the converse is true: does glucagon become a more effective stimulus of glucose production following a period of acute hypoglucagonemia? To determine this, somatostatin was infused along with basal replacement amounts of glucagon (0.65 ng/mg x min) and insulin (228 microU/kg x min) into five postabsorptive conscious dogs. After 1.5 h of basal hormone replacement, the glucagon infusion was terminated and a selective fall in the plasma glucagon level (75 +/- 6 to 30 +/- 4 pg/ml) occurred. This resulted in a drop in tracer (3H-glucose)-determined glucose production from 3.0 +/- 0.4 to 1.5 +/- 0.3 mg/kg x min. The plasma insulin level remained unchanged at 10 +/- 1 microU/ml throughout the experiment. Euglycemia (110 +/- 4 mg/dl) was maintained by exogenous glucose infusion. After 3 h of glucagon lack, restoration of the glucagon infusion returned the IRG level to control values (78 +/- 6 pg/ml) but restored glucose output only partially (42 +/- 9%), necessitating continued glucose infusion to preserve euglycemia. Repetition of the experiment in dogs whose pancreatic glucoregulatory feedback loops were broken surgically (two-stage pancreatectomy) rather than pharmacologically resulted in similar findings. It is concluded that glucagon deficiency of 3-h duration leads to a decrease, rather than an increase, in hepatic sensitivity to glucagon.
Reducing the impact of failures in Next-Generation Optical Access Networks (2012)

Reliability performance of next generation optical access (NGOA) networks offering high bandwidth and large service coverage is evaluated. A particular attention is paid to the reduction of the impact of failures in NGOA.
The Selective Oestrogen Receptor Modulator, LY362321, is Not Neuroprotective in a Rat Model of Transient Focal Ischaemia (2008)

Selective oestrogen receptor modulators (SERMs) may offer improved alternatives to oestrogen as neuroprotectants in experimental stroke. The present study investigated the role of a novel SERM, LY362321, in a rat model of transient middle cerebral artery occlusion (MCAO). Female Sprague-Dawley rats were ovariectomised and began receiving daily s.c. injections of either 1 mg/kg (n = 13), 10 mg/kg (n = 14) of LY362321, or vehicle (n = 13). The left MCA was temporarily occluded (90 min), with cortical blood flow monitoring, at 12 days post ovariectomy. Sensorimotor function was assessed using a neurological score prior to the MCAO and daily for 3 days following the MCAO. Tissue was processed for infarct volume assessment using 2,3,5-triphenyltetra-zolium chloride staining. The results indicated that there were no significant differences amongst groups in cortical blood flow during the MCAO. Furthermore, there was no significant difference in infarct size amongst vehicle, 1, and 10 mg/kg treated animals: 22.9 +/- 5.0, 16.7 +/- 4.2, and 21.1 +/- 4.1, respectively, one-way anova [F(2,32) = 0.542, P = 0.587]. The MCAO induced a significant decline in neurological score in the vehicle group (from 14 to 7 at 24 h post-MCAO) but this was not significantly affected by LY362321 at either dose. In conclusion, pretreatment with a low or high dose of the novel SERM LY362321 did not significantly influence cerebral blood flow, infarct volume, or sensorimotor function in rats exposed to transient MCAO.
Excitonic and pair-related photoluminescence in ZnSe nanowires (2008)

It has been established that deviations from stoichiometry during the growth of ZnSe crystals result in point defects, which influence its electronic properties. We report on detailed photoluminescence results and their systematic analysis for ZnSe nanowires. We studied photoluminescence from vapor-phase grown undoped ZnSe nanowires grown under excess Zn conditions, and in particular the dependence on excitation intensity. Luminescence spectra were characterized by strong near-band-edge luminescence with negligible deep-level emission. We observed excitonic emission at 2.794 eV related to the neutral donor at VSe. The binding energy of the exciton was found to be 7 meV, and that of the donor was 35 meV. Two donor-acceptor pair transitions at 2.714 and 2.686 eV were also observed, which can be related to the defect complexes of native defects with other native defects or with common unintentional shallow donors and acceptors. The ionization energies of both donors were 27 meV, whereas those of the acceptors were 102 and 139 meV, respectively.
Purinergic transmission in the retina (1998)

The retina is a complex network of cells and neurotransmitters that function as a light-detecting array and as a signal-processor system. Apart from the neurotransmitters involved in retinal neurotransmission, other substances such as adenosine and ATP, are emerging as important co-transmitters or modulators in this part of the eye. These compounds are naturally occurring purines, which exert their action by means of specific receptors. ATP acts on two main types of receptors, P2X (ionotropic) and P2Y (metabotropic), while adenosine acts on four different adenosine receptors coupled to adenylate cyclase and termed A1, A2A, A2B and A3. Adenosine A1 receptors are present in the inner nuclear and plexiform layers and in ganglion cells. A2 receptors are important in the retinal pigmented epithelium (RPE) and in photoreceptors. P2Y receptors are present in the RPE and inner plexiform layer, while P2X perform important roles in photoreceptors, the inner plexiform layer and in the ganglion cells.
Examining the relationship between face processing and social interaction behavior in children with and without autism spectrum disorder (2014)

Face memory strongly predicts relevant social engagement patterns in both children with and without ASD. Impairment in facial memory is associated with reduced 'real-world' social interaction and more self-play, whereas higher performance in face memory predicts more cooperative play. Results highlight the strong connection between face memory and reciprocal social interaction, suggesting that improvement in one may benefit the other.
Inter-AS Requirements for the Path Computation Element Communication Protocol (PCECP) (2008)

Multiprotocol Label Switching Traffic Engineered (MPLS TE) Label Switched Paths (LSPs) may be established wholly within an Autonomous System (AS) or may cross AS boundaries.The Path Computation Element (PCE) is a component that is capable of computing constrained paths for (G)MPLS TE LSPs.The PCE Communication Protocol (PCECP) is defined to allow communication between Path Computation Clients (PCCs) and PCEs, as well as between PCEs.The PCECP is used to request constrained paths and to supply computed paths in response.Generic requirements for the PCECP are set out in "Path Computation Element (PCE) Communication Protocol Generic Requirements", RFC 4657.This document extends those requirements to cover the use of PCECP in support of inter-AS MPLS TE.
Psychophysical interactions with a double-slit interference pattern: Exploratory evidence of a causal influence (2021)

An experiment we conducted from 2012 to 2013, which had not been previously reported, was designed to explore possible psychophysical effects resulting from the interaction of a human mind with a quantum system. Participants focused their attention toward or away from the slits in a double-slit optical system to see if the interference pattern would be affected. Data were collected from 25 people in individual half-hour sessions; each person repeated the test ten times for a total of 250 planned sessions. “Sham” sessions designed to mimic the experimental sessions without observers present were run immediately before and after as controls. Based on the planned analysis, no evidence for a psychophysical effect was found. Because this experiment differed in two essential ways from similar, previously reported double-slit experiments, two exploratory analyses were developed, one based on a simple spectral analysis of the interference pattern and the other based on fringe visibility. For the experimental data, the outcome supported a pattern of results predicted by a causal psychophysical effect, with the spectral metric resulting in a 3.4 sigma effect ( p = 0.0003), and the fringe visibility metric resulting in 7 of 22 fringes tested above 2.3 sigma after adjustment for type I error inflation, with one of those fringes at 4.3 sigma above chance ( p = 0.00001). The same analyses applied to the sham data showed uniformly null outcomes. Other analyses exploring the potential that these results were due to mundane artifacts, such as fluctuations in temperature or vibration, showed no evidence of such influences. Future studies using the same protocols and analytical methods will be required to determine if these exploratory results are idiosyncratic or reflect a genuine psychophysical influence.
Consumer Acceptance and Willingness to Pay for Instant Cereal Products With Food-to-Food Fortification in Eldoret, Kenya (2020)

There is a potential market for improved cereal products in Kenya, but more for <i>uji</i> than for <i>ugali</i>, especially with instant, mixed, and whole flour. Acceptable and affordable products, fortified with other foods that are locally available, however, still need to be developed, especially for <i>ugali</i>.
Testing Convex Truncation (2023)

We study the basic statistical problem of testing whether normally distributed $n$-dimensional data has been truncated, i.e. altered by only retaining points that lie in some unknown truncation set $S \subseteq \mathbb{R}^n$. As our main algorithmic results, (1) We give a computationally efficient $O(n)$-sample algorithm that can distinguish the standard normal distribution $N(0,I_n)$ from $N(0,I_n)$ conditioned on an unknown and arbitrary convex set $S$. (2) We give a different computationally efficient $O(n)$-sample algorithm that can distinguish $N(0,I_n)$ from $N(0,I_n)$ conditioned on an unknown and arbitrary mixture of symmetric convex sets. These results stand in sharp contrast with known results for learning or testing convex bodies with respect to the normal distribution or learning convex-truncated normal distributions, where state-of-the-art algorithms require essentially $n^{\sqrt{n}}$ samples. An easy argument shows that no finite number of samples suffices to distinguish $N(0,I_n)$ from an unknown and arbitrary mixture of general (not necessarily symmetric) convex sets, so no common generalization of results (1) and (2) above is possible. We also prove that any algorithm (computationally efficient or otherwise) that can distinguish $N(0,I_n)$ from $N(0,I_n)$ conditioned on an unknown symmetric convex set must use $Ω(n)$ samples. This shows that the sample complexity of each of our algorithms is optimal up to a constant factor.
Adaptive search range adjustment scheme for fast motion estimation in AVC/H.264 (2011)

AVC/H.264 supports the use of multiple reference frames (e.g., 5 frames in AVC/H.264) for motion estimation (ME), which demands a huge computational complexity in ME. We propose an adaptive search range adjustment scheme to reduce the computational complexity of ME by reducing the search range of each reference frame-from the (t-1)'th frame to the (t-5)'th frame-for each macroblock. Based on the statistical analysis that the 16×16 mode type is dominantly selected rather than the other block partition mode types, the proposed method reduces the search range of the remaining ME process in the given reference frame according to the motion vector (MV) position of the 16×16 block ME. In the case of the (t-1)'th frame, the MV position of the 8×8 block ME-in addition to that of 16×16 block ME-is also used for the search range reduction to sub-block partition mode types of the 8×8 block. The experimental results show that the proposed method reduces about 50% and 65% of the total encoding time over CIF/SIF and full HD test sequences, respectively, without any noticeable visual degradation, compared to the full search method of the AVC/H.264 encoder.
Nanoencapsulation of Cytochrome <i>c</i> and Horseradish Peroxidase at the Galleries of α-Zirconium Phosphate (1997)

Cytochrome c (Cyt c) and horseradish peroxidase (HRP) are encapsulated in the galleries of α-zirconium phosphate (Zr[HPO4]2·nH2O, α-ZrP) and α-zirconium phosphonate Zr(PO3CH2COOH)2·nH2O (α-ZrPAA), under mild conditions (pH 7.2, room temperature). Thermal stability, peroxidase activity, and the spectral features of the bound proteins are largely preserved. The binding constants for α-ZrP are in the range 1−100 μM-1. Cyt c shows a much higher affinity for α-ZrP (42/μM) than HRP (1.5/μM) and α-ZrP has a much higher affinity for Cyt c than α-ZrPAA. The binding interactions are, thus, sensitive to the surface functional groups of the protein as well as the ZrP matrix. The α, β, and the soret absorption bands of heme protein−α-ZrP composites were essentially superimposable with those of the native protein. The FTIR spectra of the protein−phosphate composites are superimposable with those of the native proteins indicating no major changes in the secondary structures of the bound proteins. Powder diffraction data of protein/α-ZrP indicate increases in the interlayer spacings from 7.6 Å for α-ZrP to ∼33 Å for protein/α-ZrP samples, providing strong evidence for the intercalation of proteins in the galleries. Dithionite or ascorbate reduces ferric Cyt c/α-ZrP to the ferrous form, while hydrogen peroxide rapidly reacts with HRP/α-ZrP to form the green intermediate. Ferricyanide readily oxidizes the ferrous Cyt c/α-ZrP to ferric Cyt c/α-ZrP, and α-ZrP bound Cyt c retains its peroxidase activity. The thermal stability of the bound Cyt c is similar to that of free protein.
The pilus and porin of Neisseria gonorrhoeae cooperatively induce Ca2+ transients in infected epithelial cells (2005)

Purified pili and porin from Neisseria quickly mobilize calcium (Ca(2+)) stores in monocytes and epithelial cells, ultimately influencing host cell viability as well as bacterial intracellular survival. Here, we examined the Ca(2+) transients induced in human epithelial cells during infection by live, piliated N. gonorrhoeae. Porin induced an influx of Ca(2+) from the extracellular medium less than 60 s post infection. The porin-induced transient is followed by a pilus-induced release of Ca(2+) from intracellular stores. The timing of these events is similar to that observed using purified proteins. Interestingly, the porin-induced Ca(2+) flux is required for the pilus-induced transient, indicating that the pilus-induced Ca(2+) release is, itself, Ca(2+) dependent. Several lines of evidence indicate that porin is present on pili. Moreover, pilus retraction strongly influences the porin- and pilus-induced Ca(2+) fluxes. These and other results strongly suggest that the pilus and porin cooperate to modulate calcium signalling in epithelial cells, and propose a model to explain how N. gonorrhoeae triggers Ca(2+) transients in the initial stages of pilus-mediated attachment.
Abscheidung, Charakterisierung und Anwendung von Plasma‐Polymerschichten auf HMDSO‐Basis (2006)

Abstract Hochwertige siliziumorganische Schichten lassen sich mittels plasmachemischer Gasphasenabscheidung unter Verwendung des Monomers Hexamethyldisiloxan (HMDSO) herstellen. Im vorliegenden Artikel werden abscheidungstechnische, analytische und anwendungsrelevante Aspekte der HMDSO/O 2 ‐Plasmabeschichtung vorgestellt. Anhand von XPS‐Untersuchungen wird aufgezeigt, dass sich durch geeignete Wahl von Plasmaleistung und Gasmischungsverhältnis der organische bzw. anorganische Charakter der Schichten einstellen lässt. Somit können insbesondere anwendungstechnisch interessante Gradienten‐ und Wechselschichtsysteme hergestellt werden. Mit der Sekundärneutralteilchen‐Massenspektrometrie kann die Zusammensetzung dieser Schichten tiefenabhängig gemessen werden. Rasterkraftmikroskopische Untersuchungen zeigen, dass die Oberflächenrauheiten der Schichten durch das Auftreten halbkugelförmiger Agglomerate bestimmt werden. Diese treten umso deutlicher in Erscheinung, je glasartiger die Schichten sind. Als Applikationsbeispiel wird eine HMDSO‐Plasmabehandlung von Elastomeren vorgestellt. Durch eine geeignete Prozessführung kann das tribologische Verhalten von Elastomerbauteilen deutlich verbessert werden. Die vorgestellten Arbeiten sind im Rahmen des BMBF‐Verbundprojektes “Nano‐Funktionalisierung von Grenzflächen für Daten‐, Textil‐, Gebäude‐, Medizin‐, Bio‐, und Raumfahrttechnik” durchgeführt worden.
Semiconductor and fiber laser development at Air Force Research Laboratory Directed Energy Directorate (1998)

This paper will review Air Force Research Laboratory Directed Energy Directorate development programs which provide high-efficiency electric semiconductor diode lasers and diode pumped fiber lasers for a host of applications including free space communications, laser radar, illuminators, trackers and designators.
Placement for Reliability and Producibility (2020)

Placement techniques were initially developed to minimize the total weighted wire length necessary for complete interconnection. But with the increased demand for high quality and reliable performance over time, techniques to address placement for reliability and producibility also became necessary. The reliability of an electronic assembly is based in part on the failure mechanisms of its individual parts and interconnections. Failure mechanisms can be accelerated by temperature extremes, temperature changes and gradients, thermal-mechanical stresses, vibration, corrosion and electrical stresses. Placement for producibility involves addressing the manufacturing and assembly processes, including testing and rework, by taking into account the equipment used, the process flow and human factors. Placement for reliability requires an understanding of the actual operating conditions, under which the assembly will be used and the physical mechanisms involved in potential failures.
A novel whole-cell lysate kinase assay identifies substrates of the p38 MAPK in differentiating myoblasts (2012)

Our results suggest p38α has a novel cytoplasmic role during myogenesis and that its unique cellular localisation may be why p38β and other isoforms cannot compensate for its absence. The substrate-finding approach presented here also provides a necessary tool for studying the hundreds of protein kinases that exist and for uncovering the deeper mechanisms of phosphorylation-dependent cell signalling.
Three-dimensional interactions of a free jet with a perpendicular synthetic jet (2007)

Three-dimensional interaction of an axisymmetric free jet with a single synthetic jet that is oriented perpendicular to the free jet was investigated experimentally using PIV. The main objective was to investigate the effect of the upstream location of the synthetic jet, inside the nozzle of the main jet ( Re U e = 6600). The interaction location of the synthetic jet (for a range of momentum coefficients) was varied from 0.4 to 1.4 orifice diameters upstream of the main jet exit plane. The synthetic jet was driven at a frequency of 1000 Hz, which corresponds to a Strouhal number of 0.16 (within the range of unstable modes of the free jet). To better explore the complex flow field resulting from the interaction, a reduction technique was used where 3D flow renderings were calculated from multiple 2D measurement planes. The interaction is affected by two mechanisms: (1) direct impact of the synthetic jet into the main jet, and (2) amplification of unstable modes of the main jet. When the momentum coefficient is increased, the synthetic jet penetrates deeper into the main jet flow creating larger streamwise vortical structures and increasing the main jet width. Increasing the distance between the synthetic jet exit and the main jet nozzle exit the effectiveness of the synthetic jet's impulse decreases, resulting in smaller jet vectoring, weaker streamwise vortical structures, and decreased turbulence levels. When compared to a continuous control jet of the same momentum coefficient and upstream location, the effects are significantly different.
Correction to Total Synthesis of Lysergic Acid (2014)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionNEXTORIGINAL ARTICLEThis notice is a correctionCorrection to Total Synthesis of Lysergic AcidSatoshi Umezaki, Satoshi Yokoshima, and Tohru Fukuyama*Cite this: Org. Lett. 2014, 16, 17, 4692Publication Date (Web):August 12, 2014Publication History Received4 August 2014Published online12 August 2014Published inissue 5 September 2014https://pubs.acs.org/doi/10.1021/ol502316xhttps://doi.org/10.1021/ol502316xcorrectionACS PublicationsCopyright © 2014 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views2237Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (113 KB) Get e-AlertscloseSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts