gebhart/patrepeval huggingface dataset:
Veliparib (ABT-888) or placebo combined with carboplatin and paclitaxel in patients with previously untreated advanced/metastatic squamous (Sq) non-small cell lung cancer (NSCLC): A randomized phase 3 trial. (2015)

TPS8107 Background: NSCLC is often diagnosed at an advanced stage, conferring a poor prognosis. The current standard of care for first-line treatment comprises platinum-based regimens. Veliparib is a potent, orally bioavailable PARP1/2 inhibitor that can delay DNA repair following damage induced by chemotherapeutic agents. In preclinical tumor models, veliparib has been shown to enhance antitumor activity of carboplatin, and phase 1 data show that it can be safely combined with carboplatin and paclitaxel. A phase 2 study indicated favorable efficacy for veliparib plus carboplatin and paclitaxel vs placebo plus carboplatin and paclitaxel in the subgroup of patients with Sq NSCLC (Ramalingam et al. Ann Oncol 2014;25(Suppl 4):1234P). Based on these results, this phase 3 pivotal trial has been initiated. Methods: This is a randomized, double blind, multicenter, phase 3 trial (NCT02106546). Patients ( ≥ 18 years) who have received no prior chemotherapy or chemoradiotherapy for advanced/metastatic Sq NSCLC are randomized 1:1 to oral veliparib (120 mg) or placebo, twice daily on Days −2 through 5 (7 consecutive days) of 21-day cycles. Randomization is stratified by tumor extent, smoking history, ECOG performance status, and geographic region. All patients receive carboplatin (AUC 6 mg/mL/min i.v.) and paclitaxel (200 mg/m2 i.v.) on Day 1 of each 21-day cycle. Treatment continues for a maximum of 6 cycles, or until radiographic progression or unacceptable toxicity. The primary study objective is to determine if the addition of veliparib to carboplatin and paclitaxel improves overall survival, compared with placebo plus carboplatin and paclitaxel. Secondary objectives are to assess progression-free survival and objective response rate. Duration of overall response, safety, tolerability, ECOG performance status, and quality of life are also evaluated. Sites from 37 countries are planned for trial participation. Recruitment began in Apr 2014 and 900 patients are planned for enrollment. Clinical trial information: NCT02106546.
Supplementary Figure SF3 from Antibody Binding and Neutralization of Live SARS-CoV-2 Variants Including BA.4/5 Following Booster Vaccination of Patients with B-cell Malignancies (2023)

&lt;p&gt;Supplemental Figure 3. Kinetics of serologic response after booster vaccination.&lt;/p&gt;
Efficient Organic-Dye-Sensitized Nanocrystalline TiO2 Solar Cells (2006)

We have developed dye-sensitized nanocrystalline TiO <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sub> solar cells (DSSCs) based on organic-dye photosensitizers. DSSCs based on the organic dyes gave good performance of incident-photon-to-current conversion efficiencies in the range of 400 to 800 nm. Solar energy-to-electricity conversion efficiencies of up to 7.6% were obtained with DSSCs based on coumarin dyes (NKX-2677 and NKX-2883) under AM 1.5 G irradiation (100 mW cm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">-2</sup> ). Our results strongly suggest that organic-dye photosensitizers can be successfully designed for use in DSSCs and demonstrate the promising performance of DSSCs based on organic dyes
Formation of Cubic Zirconia by Reactive Arc Evaporation in a Mixture of Nitrogen‐Oxygen Reactive Gas (2010)

Abstract Zr(N)O coatings being synthesized by cathodic arc evaporation (P3e™ technology) show that cubic zirconia, ZrO 2 , can be formed at low substrate temperatures of 550 °C using nitrogen‐oxygen reactive gas mixtures during deposition. The structural properties of the coatings obtained for different nitrogen‐oxygen ratios have been investigated by X‐Ray Diffraction (XRD) techniques. The composition of the layers was studied by RBS and ERDA and the layers morphology by cross sectional SEM. For low oxygen flows, the cubic ZrN and ZrO phase were formed while increased oxygen flow results in a transition starting from the orthorhombic to the cubic and to the monoclinic ZrO 2 phase. The phase stability of the cubic ZrO 2 phase has been investigated by in situ high temperatures XRD studies in air and reveals a multi step phase transformation starting at about 550 °C with a change to the tetragonal ZrO 2 phase and the further transition to the monoclinic phase at higher temperatures.
Conical emission by 2-ps excitation of potassium vapor (2001)

Conical emission, redshifted from the atomic resonance, is observed when a ∼2-ps laser beam, blueshifted from resonance, propagates through potassium vapor. In contrast, no cone is visible when a 150-fs pulse is used. The 2-ps-pulse-induced cone has a unique, small, angular spread of Δθ/θ≈0.1, compared with Δθ/θ≈0.3 from other pulsed experiments, which used 25-ps–5-ns-excitation pulses. In addition, the fraction of the 2-ps-pulse power emitted in the cone reached 7.5%, far exceeding this fraction from the longer-pulse experiments. An additional, unexpected result is that the spectral width of the laser pulse is narrower, without significant intensity loss, after propagation through the vapor. The vapor densities and laser detunings that yield cones in the present experiment are similar to those from the longer-pulse experiments. Although the 2-ps-pulse spectrum partially overlaps the resonance, the cone spectrum and cone angles versus density and laser detuning are similar to those previously reported for nanosecond pulses. The fourth (blue-detuned) wave required for satisfying four-wave mixing is absent, again equivalent to what is observed in the nanosecond experiments. The physical origin of cone emission by pulsed excitation of atomic vapors is still largely unknown, and this high efficiency and narrow angular spread of a spectrally broad cone further contradicts existing models, perhaps ultimately providing a clue to a correct explanation.
Analytical model for polarization-dependent light propagation in waveguide arrays and applications (2014)

We study the polarization properties of elliptical femtosecond-laser-written waveguide arrays. An analytical model is presented to explain the asymmetry of the spatial transverse profiles of linearly polarized modes in these waveguides. This asymmetry produces a polarization-dependent coupling coefficient, between adjacent waveguides, which strongly affects the propagation of light in a lattice. Our analysis explains how this effect can be exploited to tune the final intensity distribution of light propagated through the array and links the properties of a polarizing beam splitter in integrated optical circuits to the geometry of the waveguides.
Systematic review and quality analysis of emerging diagnostic measures for calcium pyrophosphate crystal deposition disease (2016)

Though CCA and CR remain reference standards for CPPD diagnosis, U/S, DECT and Raman spectroscopy are emerging U/S sensitivity appears to be superior to CR. We identified major unmet needs, including for randomised, blinded, controlled studies of CPPD diagnostic performance and rigorous analyses of 4 T MRI and other emerging modalities.
Reviewer #2 (Public Review): E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation (2023)

The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt signaling is associated with a wide range of pathologies in humans. Tight regulation of Wnt/Wg signaling is required for the maintenance of proper cellular homeostasis. Here we report a novel role of E3 ubiquitin ligase Deltex in Wg signaling regulation. Drosophila dx genetically interacts with wg and its pathway components. Further, Dx LOF results in a reduced spreading of Wg while its over-expression expands the diffusion gradient of the morphogen. We attribute this change in Wg gradient to the endocytosis of Wg through Dx which directly affects the short and long-range Wg targets. We also demonstrate the role of Dx in the regulation of Wg effector Armadillo where Dx down-regulates Arm through proteasomal degradation. We also showed the conservation of Dx function in the mammalian system where DTX1 is shown to bind with β-catenin and facilitates its proteolytic degradation, spotlighting a novel step that potentially modulates Wnt/Wg signaling cascade.
A New Regioselective Heck Vinylation with Enamides. Synthesis and Investigation of Fluorous-Tagged Bidentate Ligands for Fast Separation (2003)

Internal ligand-controlled Heck vinylations of enamides were performed with high regioselectivity and delivered moderate to good yields of dienamides. Controlled heating by microwave irradiation accelerated the palladium-catalyzed reactions, and full conversions were achieved after reaction times of only 15-30 min. New bidentate fluorous-tagged 1,3-bis(diphenylphosphino)propane ligands (F-dppp's) were synthesized and examined. The cationic vinylations of the enamides with F-dppp ligands rendered essentially the same alpha-selectivity and catalytic activity as in those vinylations where nonfluorous ligands were employed. After reaction, the fluorous-tagged ligand material was easily removed by convenient solid fluorous phase separation. The high selectivity, simplicity, and generality of the experimental procedure should make this approach to 2-acylamino-1,3-butadienes attractive.
Feasible Action-Space Reduction as a Metric of Causal Responsibility in Multi-Agent Spatial Interactions (2023)

Modelling causal responsibility in multi-agent spatial interactions is crucial for safety and efficiency of interactions of humans with autonomous agents. However, current formal metrics and models of responsibility either lack grounding in ethical and philosophical concepts of responsibility, or cannot be applied to spatial interactions. In this work we propose a metric of causal responsibility which is tailored to multi-agent spatial interactions, for instance interactions in traffic. In such interactions, a given agent can, by reducing another agent's feasible action space, influence the latter. Therefore, we propose feasible action space reduction (FeAR) as a metric of causal responsibility among agents. Specifically, we look at ex-post causal responsibility for simultaneous actions. We propose the use of Moves de Rigueur (MdR) - a consistent set of prescribed actions for agents - to model the effect of norms on responsibility allocation. We apply the metric in a grid world simulation for spatial interactions and show how the actions, contexts, and norms affect the causal responsibility ascribed to agents. Finally, we demonstrate the application of this metric in complex multi-agent interactions. We argue that the FeAR metric is a step towards an interdisciplinary framework for quantifying responsibility that is needed to ensure safety and meaningful human control in human-AI systems.
Raman Thermometry For Sensing Of Hot Carriers In Gold Nanoparticle-Based Bimetallic Photocatalysts (2022)

Raman thermometry is a distinctive method of measuring the local temperature in nanoplasmonic systems through acquisition and analysis of the Stokes and anti-Stokes scattering amplitudes in a Raman spectrum. In this work, we present a nanoscopic temperature sensor that estimates the local temperature during hot carrier-mediated photocatalytic degradation of methylene blue (MB) dye molecules on Au-Pt core shell nanoislands on a glass substrate. The temperature was recorded at different Raman modes and the local heating of chemical bonds in the molecules to strong interaction with plasmonic hot carriers, was validated.
DNA Sequence Context and Protein Composition Modulate HMG-Domain Protein Recognition of Cisplatin-Modified DNA (1997)

ADVERTISEMENT RETURN TO ISSUEPREVAddition/CorrectionDNA Sequence Context and Protein Composition Modulate HMG-Domain Protein Recognition of Cisplatin-Modified DNAShari U. Dunham and Stephen J. LippardCite this: Biochemistry 1997, 36, 45, 13972Publication Date (Web):November 11, 1997Publication History Published online11 November 1997Published inissue 1 November 1997https://pubs.acs.org/doi/10.1021/bi9750246https://doi.org/10.1021/bi9750246correctionACS PublicationsCopyright © 1997 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views402Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (15 KB) Get e-Alertsclose Get e-Alerts
Recombinant AAV-Mediated BEST1 Transfer to the Retinal Pigment Epithelium: Analysis of Serotype-Dependent Retinal Effects (2013)

Mutations in the BEST1 gene constitute an underlying cause of juvenile macular dystrophies, a group of retinal disorders commonly referred to as bestrophinopathies and usually diagnosed in early childhood or adolescence. The disease primarily affects macular and paramacular regions of the eye leading to major declines in central vision later in life. Currently, there is no cure or surgical management for BEST1-associated disorders. The recently characterized human disease counterpart, canine multifocal retinopathy (cmr), recapitulates a full spectrum of clinical and molecular features observed in human bestrophinopathies and offers a valuable model system for development and testing of therapeutic strategies. In this study, the specificity, efficiency and safety of rAAV-mediated transgene expression driven by the human VMD2 promoter were assessed in wild-type canine retinae. While the subretinal delivery of rAAV2/1 vector serotype was associated with cone damage in the retina when BEST1 and GFP were co-expressed, the rAAV2/2 vector serotype carrying either GFP reporter or BEST1 transgene under control of human VMD2 promoter was safe, and enabled specific transduction of the RPE cell monolayer that was stable for up to 6 months post injection. These encouraging studies with the rAAV2/2 vector lay the groundwork for development of gene augmentation therapy for human bestrophinopathies.
Drivers of ESBL-producing <i>Escherichia coli</i> dynamics in calf fattening farms: a modelling study (2020)

Abstract The contribution of bacteria in livestock to the global burden of antimicrobial resistance raises concerns worldwide. However, the dynamics of selection and diffusion of antimicrobial resistance in farm animals are not fully understood. Here, we used veal calf fattening farms as a model system, as they are a known reservoir of Extended Spectrum β-Lactamase-producing Escherichia coli (ESBL-EC). Longitudinal data of ESBL-EC carriage and antimicrobial use (AMU) were collected from three veal calf farms during the entire fattening process. We developed 18 agent-based mechanistic models to assess different hypotheses regarding the main drivers of ESBL-EC dynamics in calves. The models were independently fitted to the longitudinal data using Markov Chain Monte Carlo and the best model was selected. Within-farm transmission between individuals and sporadic events of contamination were found to drive ESBL-EC dynamics on farms. In the absence of AMU, the median carriage duration of ESBL-EC was estimated to be 19.6 days (95% credible interval: [12.7; 33.3]). In the best model, AMU was found to influence ESBL-EC dynamics, by affecting ESBL-EC clearance rather than acquisition. This effect of AMU was estimated to decrease gradually after the end of exposure and to disappear after 62.5 days [50.0; 76.9]. Moreover, using a simulation study, we quantified the efficacy of ESBL-EC mitigation strategies. Decreasing ESBL-EC prevalence by 50% on arrival at the fattening farm reduced prevalence at slaughter age by 33.3%. Completely eliminating the use of selective antibiotics had a strong effect on average ESBL-EC prevalence (relative reduction of 79.6%), but the effect was mild if this use was only decreased by 50% compared to baseline (relative reduction of 3.7%).
Design and Optimization of 2×211-kW SiC-Based Aircraft Propulsion Inverter System with High Power Density and High Efficiency (2023)

The power rating of the motor drive system in more electric aircrafts is continuously increasing and the Silicon Carbide (SiC) device enables the higher power density and higher efficiency. This paper introduces the design and optimization of a 2×211-kW SiC-based aircraft motor drive system, including the topology selection, parameter optimization, busbar design, device current sampling, phase current reconstruction, short-circuit protection, EMI filter design, insulation and thermal design at high altitudes, and control schemes. Three-level (3-L) T -Type is selected due to the smaller EMI filter compared to the conventional two-level (2-L) inverter. To achieve a high density, the conventional laminated busbar, bulky hall sensors, shunt resistor, and de-sat short-circuit protection are eliminated in this design, and these functions are integrated into a gate driver board, which includes the decoupling path, PCB-based Rogowski coil current sensor, and gate driver circuits. Planar EMI filters on DC and AC sides are designed to suppress the bearing current and meet the standard DO-160. The insulation and thermal design should be paid special attention for the high-altitude operation and the design rules are discussed in this paper. A neutral point (NP) potential balance scheme is designed to mitigate the NP ripple for high-speed operation, and a loss-balance scheme is proposed to solve the overheating issue of clamping switches caused by the breakaway torque. All the performances of the 2×211-kW SiC-based motor drive system are verified with experiments. The power density and efficiency of the motor drive system are up to 19.5 kW/kg and 99 % respectively.
Spectroscopic and molecular docking studies reveal binding characteristics of nazartinib (EGF816) to human serum albumin (2020)

The interactions of novel anti-cancer therapeutic agents with the different plasma and tissue components, specifically serum albumins, have lately gained considerable attention due to the significant influence of such interactions on the pharmacokinetics and/or -dynamics of this important class of therapeutics. Nazartinib (EGF 816; NAZ) is a new anti-cancer candidate proposed as a third-generation epidermal growth factor receptor tyrosine kinase inhibitor that is being developed and clinically tested for the management of non-small cell lung cancer. The current study aimed to characterize the interaction between NAZ and human serum albumin (HSA) using experimental and theoretical approaches. Experimental results of fluorescence quenching of HSA induced by NAZ revealed the development of a statically formed complex between NAZ and HSA. Interpretation of the observed fluorescence data using Stern-Volmer, Lineweaver-Burk and double-log formulae resulted in binding constants for HSA-NAZ complex in the range of (2.34-2.81) × 10<sup>4</sup> M<sup>-1</sup> over the studied temperatures. These computed values were further used to elucidate thermodynamic attributes of the interaction, which showed that NAZ spontaneously binds to HSA with a postulated electrostatic force-driven interaction. This was further verified by theoretical examination of the NAZ docking on the HSA surface that revealed an HSA-NAZ complex where NAZ is bound to HSA Sudlow site I driven by hydrogen bonding in addition to electrostatic forces in the form of pi-H bond. The HSA binding pocket for NAZ was shown to encompass ARG 257, ARG 222, LYS 199 and GLU 292 with a total binding energy of -25.59 kJ mol<sup>-1</sup>.
Corannulene vs. C60-fullerene in metal binding reactions: A direct DFT and X-ray structural comparison (2007)

DFT calculations and X-ray crystallography were used to directly compare the reactivity of the convex carbon surfaces of C20H10-corannulene and the C60-fullerene toward the diruthenium(I,I) metal cluster.
On a real-time 12.1 Gb/s OFDM transmitter architecture (2010)

A real-time OFDM transmitter architecture for 12.1 Gb/s bitrate has been optimized for optimum performance at lowest DSP complexity. We achieved 22.3 dB in Q-factor for 7 bit IFFTs twiddle factors and 6 bit resolution of DAC.
Preparation and Evaluation of Hydrogel-Composites from Methacrylated Hyaluronic Acid, Alginate, and Gelatin for Tissue Engineering (2011)

Hydrogels are three-dimensional water-insoluble hydrophilic natural or synthetic polymer networks made up of crosslinked water-soluble polymers. The purpose of this study was to develop and directly compare photo crosslinked hydrogels on the basis of pure gelatin, alginate and hyaluronic acid as well as their blends. The functionalization of starting materials with methacrylate moieties was evaluated by 1H-NMR spectroscopy. Hydrogels were prepared from methacrylates by photo cross-linking using UV light. The effect of changing the hydrogel composition was quantified through examination of hydrogel swelling behavior and rheological properties. In addition, the viability and adhesion of neonatal rat cardiomyocytes (NRCM) seeded onto the hydrogels was examined by in vivo imaging of NRCM-mediated scaffold contraction as well as by histological evaluation after immunostaining. Biological testing showed good biocompatibility and cell survival in the presence of all materials discussed. Adhesion of cells could only be observed in the presence of gelatin. Blends of gelatin, alginate and hyaluronic acid are promising candidates for the generation of non-toxic, biocompatible hydrogel scaffolds for tissue engineering. Variation of individual compound ratios in the blends can be used for a precise control of mechanical properties and may allow wide-ranging uses in various tissue engineering applications with different mechanical requirements.
Visible-Light-Promoted Biomimetic Reductive Functionalization of Quaternary Benzophenanthridine Alkaloids (2021)

Reduction of an iminium C═N double bond is the most important phase I metabolism process associated with the cytotoxic property of quaternary benzophenanthridine alkaloids (QBAs). Inspired by the light-mediated reduction of QBAs with nicotinamide adenine dinucleotide, a visible-light-promoted reductive functionalization reaction of QBAs is reported in this study. C4-Alkyl-1,4-dihydropyridines (DHPs) enable the direct reductive alkylation of QBA independently, serving as both single-electron-transfer reductant reagents under irradiation with 455 nm blue light in the absence of photocatalysts and additional additives. Our protocol can be further applied to the semisynthesis of natural 6-substituted dihydrobenzophenanthridine derivatives such as <i>O</i>-acetyl maclekarpine E.