gebhart/patrepeval huggingface dataset:
A review on utilization of waste heat from domestic refrigerator (2019)

Energy plays an important role in the economic development of a country. Refrigeration and air conditioning takes in enormous energy. In real time scenario of the world, energy loss is the major crisis. By the second law of thermodynamics, energy has to be rejected to the atmosphere. A lot of heat energy is wasted in domestic refrigerator during its routine cycle. As domestic refrigerator rejects heat inside the room which make uncomfortable in summer due to increase the temperature. So it is proposed to extract the waste heat from the Refrigerator which can be used for other applications. In this, a heat recovery unit setup is installed with the domestic refrigerator. It contains a condensing coil, an air flow arrangement, a temperature sensor and some accessories. A hot box is developed to absorb the refrigeration heat exhausted from the refrigerator. By this, energy can be utilized to some extent for domestic applications. This is of great significance since domestic refrigerator has vast usage in every house.
Electrospray Ionization Mechanisms for Large Polyethylene Glycol Chains Studied Through Tandem Ion Mobility Spectrometry (2014)

Ion mobility mass spectrometry (IMS-MS) is used to investigate the abundance pattern, n(z)(m) of poly-(ethyleneglycol) (PEG) electrosprayed from water/methanol as a function of mass and charge state. We examine n(z)(m) patterns from a diversity of solution cations, primarily dimethylammonium and triethylammonium. The ability of PEG chains to initially attach to various cations in the spraying chamber, and to retain them (or not) on entering the MS, provide valuable clues on the ionization mechanism. Single chains form in highly charged and extended shapes in most buffers. But the high initial charge they hold under atmospheric pressure is lost on transit to the vacuum system for large cations. In contrast, aggregates of two or more chains carry in all buffers at most the Rayleigh charge of a water drop of the same volume. This shows either that they form via Dole's charge residue mechanism, or that highly charged and extended aggregates are ripped apart by Coulombic repulsion. IMS-IMS experiments in He confirm these findings, and provide new mechanistic insights on the stability of aggregates. When collisionally activated, initially globular dimers are stable. However, slightly nonglobular dimers projecting out a linear appendix are segregated into two monomeric chains. The breakup of a charged dimer is therefore a multi-step process, similar to the Fenn-Consta polymer extrusion mechanism. The highest activation barrier is associated to the first step, where a short chain segment carrying a single charge escapes (ion-evaporates) from a charged drop, leading then to gradual field extrusion of the whole chain out of the drop.
Bioprosthetic heart valve structural degeneration associated with metabolic syndrome: Mitigation with polyoxazoline modification (2022)

Bioprosthetic heart valves (BHV), made from glutaraldehyde-fixed xenografts, are widely used for surgical and transcatheter valve interventions but suffer from limited durability due to structural valve degeneration (SVD). We focused on metabolic syndrome (MetS), a risk factor for SVD and a highly prevalent phenotype in patients affected by valvular heart disease with a well-recognized cluster of comorbidities. Multicenter patient data (N = 251) revealed that patients with MetS were at significantly higher risk of accelerated SVD and required BHV replacement sooner. Using a next-generation proteomics approach, we identified significantly differential proteomes from leaflets of explanted BHV from MetS and non-MetS patients (N = 24). Given the significance of protein infiltration in MetS-induced SVD, we then demonstrated the protective effects of polyoxazoline modification of BHV leaflets to mitigate MetS-induced BHV biomaterial degeneration (calcification, tissue cross-linking, and microstructural changes) in an ex vivo serum model and an in vivo with MetS rat subcutaneous implants.
Synergism of antihypertensives and cholinesterase inhibitors in Alzheimer's disease (2018)

aHTN and ChEI drugs showed synergistic effects. A combination of diuretics, renin-angiotensin-aldosterone system blockers, and calcium channel blockers had the slowest cognitive decline. The chemogenomics systems pharmacology-identified molecular targets provide system pharmacology interpretation of the synergism of the drugs in clinics. The results suggest that improving vascular health is essential for AD treatment and provide a novel direction for AD drug development.
Ruminal kinetics of fatty acids and biohydrogenation processes are affected by the amount of extruded linseeds ingested by dairy cows (2009)

International audience
Host Mobility with the Host Identity Protocol (2017)

This document defines a mobility extension to the Host Identity Protocol (HIP). Specifically, this document defines a "LOCATOR_SET" parameter for HIP messages that allows for a HIP host to notify peers about alternate addresses at which it may be reached. This document also defines how the parameter can be used to preserve communications across a change to the IP address used by one or both peer hosts. The same LOCATOR_SET parameter can also be used to support end-host multihoming (as specified in RFC 8047). This document obsoletes RFC 5206.
Mobility and Power Feasibility of a Microbot Team System for Extraterrestrial Cave Exploration (2007)

Planetary scientists are greatly interested in the caves present on the Moon and Mars, however these areas present major challenges to current space robots. A new space robotics concept, microbots, is presented and a possible reference mission to Mars is discussed. The feasibility of the mobility and power systems of the microbot are analyzed within the context of the reference mission. The results of this analysis are that the microbot system is a feasible concept for a development timeline of approximately 10 years.
ChemInform Abstract: Wittig Reactions under Daylight Lamp Irradiation: Maximizing the Yields of (E)‐Alkanes. (1995)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Native Mutant Huntingtin in Human Brain (2012)

Huntington disease (HD) is caused by polyglutamine expansion in the N terminus of huntingtin (htt). Analysis of human postmortem brain lysates by SDS-PAGE and Western blot reveals htt as full-length and fragmented. Here we used Blue Native PAGE (BNP) and Western blots to study native htt in human postmortem brain. Antisera against htt detected a single band broadly migrating at 575-850 kDa in control brain and at 650-885 kDa in heterozygous and Venezuelan homozygous HD brains. Anti-polyglutamine antisera detected full-length mutant htt in HD brain. There was little htt cleavage even if lysates were pretreated with trypsin, indicating a property of native htt to resist protease cleavage. A soluble mutant htt fragment of about 180 kDa was detected with anti-htt antibody Ab1 (htt-(1-17)) and increased when lysates were treated with denaturants (SDS, 8 M urea, DTT, or trypsin) before BNP. Wild-type htt was more resistant to denaturants. Based on migration of in vitro translated htt fragments, the 180-kDa segment terminated ≈htt 670-880 amino acids. If second dimension SDS-PAGE followed BNP, the 180-kDa mutant htt was absent, and 43-50 kDa htt fragments appeared. Brain lysates from two HD mouse models expressed native full-length htt; a mutant fragment formed if lysates were pretreated with 8 M urea + DTT. Native full-length mutant htt in embryonic HD(140Q/140Q) mouse primary neurons was intact during cell death and when cell lysates were exposed to denaturants before BNP. Thus, native mutant htt occurs in brain and primary neurons as a soluble full-length monomer.
Synthesis of chiral α-amino acid-derived 1H-1,2,4-triazoles and 1,2,4-triazines (2011)

Enantiopure N-(Cbz, Fmoc, Boc, or Ac)-1H-1,2,4-triazole- (8a–p, and 8f′) and previously unknown N-Cbz-1,2,4-triazine-derived α-amino acids (11a–d, 11d′, 13a,b, and 13a′) were synthesized using microwave irradiation. Reaction conditions led unexpectedly to simultaneous cyclization, deprotection and acetylation of N-Boc-aminoacylamidrazones 7m,n to afford N-acetyl-1H-1,2,4-triazoles 8o,p.
Validation of the Argentine version of the Memory Binding Test (MBT) for Early Detection of Mild Cognitive Impairment (2016)

The Argentine version of the MBT correlated significantly with the MMSE and the memory battery and is a useful tool in the detection of MCI. The operating characteristics of the MBT are well suited, surpassing other tests commonly used for detecting MCI.
Binding of <i>Candida albicans</i> to Human CEACAM1 and CEACAM6 Modulates the Inflammatory Response of Intestinal Epithelial Cells (2017)

<i>Candida albicans</i> colonizes human mucosa, including the gastrointestinal tract, as a commensal. In immunocompromised patients, <i>C. albicans</i> can breach the intestinal epithelial barrier and cause fatal invasive infections. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1; CD66a), CEACAM5 (CEA), and CEACAM6 (CD66c) are immunomodulatory receptors expressed on human mucosa and are recruited by bacterial and viral pathogens. Here we show for the first time that a fungal pathogen (i.e., <i>C. albicans</i>) also binds directly to the extracellular domain of human CEACAM1, CEACAM3, CEACAM5, and CEACAM6. Binding was specific for human CEACAMs and mediated by the N-terminal IgV-like domain. In enterocytic C2BBe1 cells, <i>C. albicans</i> caused a transient tyrosine phosphorylation of CEACAM1 and induced higher expression of membrane-bound CEACAM1 and soluble CEACAM6. Lack of the CEACAM1 receptor after short hairpin RNA (shRNA) knockdown abolished CXCL8 (interleukin-8) secretion by C2BBe1 cells in response to <i>C. albicans</i> In CEACAM1-competent cells, the addition of recombinant soluble CEACAM6 reduced the <i>C. albicans</i>-induced CXCL8 secretion.<b>IMPORTANCE</b> The present study demonstrates for the first time that fungal pathogens can be recognized by at least four members of the immunomodulatory CEACAM receptor family: CEACAM1, -3, -5, and -6. Three of the four receptors (i.e., CEACAM1, -5, and -6) are expressed in mucosal cells of the intestinal tract, where they are implicated in immunomodulation and control of tissue homeostasis. Importantly, the interaction of the major fungal pathogen in humans <i>Candida albicans</i> with CEACAM1 and CEACAM6 resulted in an altered epithelial immune response. With respect to the broad impact of CEACAM receptors on various aspects of the innate and the adaptive immune responses, in particular epithelial, neutrophil, and T cell behavior, understanding the role of CEACAMs in the host response to fungal pathogens might help to improve management of superficial and systemic fungal infections.
<i>Diels–Alder</i> Additions to 2,2’‐Biaceanthrylene (2022)

Abstract A series of Diels–Alder reactions between the diene 2,2’‐biaceanthrylene and several dienophiles is presented. The diene is a cyclopenta‐fused polycyclic aromatic hydrocarbon with anthracene units linked by two cyclopentene rings. Depending on the dienophile, the major product was the result of a single addition (dimethyl acetylenedicarboxylate) or double addition (quinone, benzyne) to the diene. Single crystal X‐ray analysis of the quinone‐derivative shows a propeller‐like structure composed of mixed enantiomers. The synthesis and photophysical properties of these compounds are presented.
On Optimal Proactive Caching with Improving Predictions over Time (2018)

This paper considers optimal proactive caching when future demand predictions improve over time as expected to happen in most prediction systems. In particular, our model captures the correlated demand pattern that is exhibited by end users as their current activity reveals progressively more information about their future demand. It is observed in previous work that, in a network where service costs grow superlinearly with the traffic load and static predictions, proactive caching can be harnessed to flatten the load over time and minimize the cost. Nevertheless, with time varying prediction quality, a tradeoff between load flattening and accurate proactive service emerges.In this work, we formulate and investigate the optimal proactive caching design under time-varying predictions. Our objective is to minimize the time average expected service cost given a finite proactive service window. We establish a lower bound on the minimal achievable cost by any proactive caching policy, then we develop a low complexity caching policy that strikes a balance between load flattening and accurate caching. We prove that our proposed policy is asymptotically optimal as the proactive service window grows. In addition, we characterize other non-asymptotic cases where the proposed policy remains optimal. We validate our analytical results with numerical simulation and highlight relevant insights.
The Characterization of the Rat Bone Sialoprotein Knockout Phenotype (2019)

Bone sialoprotein (BSP) is an extracellular phosphoprotein that has been associated with mineralizing tissues, such as the periodontium, the fibrocartilaginous enthesis, and long bone formation. In this study, we characterized the phenotype of BSP-deficient rats. Histomorphometric analysis discovered a thinning of the acellular cementum in both 20 and 50 week-old Bsp-/- rats with no related periodontal defects and an organized periodontal ligament. Analysis of the mature quadriceps tendon (QCT) enthesis determined that BSP and osteopontin are present in the calcified fibrocartilage of wild-type rats at 14 weeks. The developing QCT enthesis of Bsp-/- rats appears similar in mineral content, collagen organization, and morphology when compared to wild-type counterparts. Digital measurements of rat tibiae show that bone length does not differ between wild-type and Bsp-/- rats at day of birth. The results of this study suggest that BSP is present in the periodontal and enthesis tissues of the rat, but the rat displays less severe phenotypes than the Bsp-/-mouse.
Evaluation of Changes to the Oral Microbiome Based on 16S rRNA Sequencing among Children Treated for Cancer (2021)

A child's mouth is the gateway to many species of bacteria. Changes in the oral microbiome may affect the health of the entire body. The aim of the study was to evaluate the changes in the oral microbiome of childhood cancer survivors. Saliva samples before and after anti-cancer treatment were collected from 20 patients aged 6-18 years, diagnosed de novo with cancer in 2018-2019 (7 girls and 13 boys, 7.5-19 years old at the second time point). Bacterial DNA was extracted, and the microbial community profiles were assessed by 16S rRNA sequencing. The relative abundances of <i>Cellulosilyticum</i> and <i>Tannerella</i> genera were found to significantly change throughout therapy (<i>p</i> = 0.043 and <i>p</i> = 0.036, respectively). However, no differences in the alpha-diversity were observed (<i>p</i> = 0.817). The unsupervised classification revealed two clusters of patients: the first with significant changes in <i>Campylobacter</i> and <i>Fusobacterium</i> abundance, and the other with change in <i>Neisseria</i>. These two groups of patients differed in median age (10.25 vs. 16.16 years; <i>p</i> = 0.004) and the length of anti-cancer therapy (19 vs. 4 months; <i>p</i> = 0.003), but not cancer type or antibiotic treatment.
Supplementary Data from An Autologous Dendritic Cell Vaccine Promotes Anticancer Immunity in Patients with Ovarian Cancer with Low Mutational Burden and Cold Tumors (2023)

Supplementary Data from An Autologous Dendritic Cell Vaccine Promotes Anticancer Immunity in Patients with Ovarian Cancer with Low Mutational Burden and Cold Tumors
Video Streaming and Cloud Gaming services over 4G and 5G: a complete network and service metrics dataset (2022)

&lt;p&gt;The enhancement reached in the telecommunication field, especially in cellular communications, has led to the emergence of multiple multimedia services. The easy supported by the mobile networks together with their novelty has triggered their popularization among society, being considered already essential in the daily life. Likewise, the increasingly connectivity dependence of these services leads to have a huge impact of the network on the user’s perception, being their adequate provision one of the biggest concerns among telcos. Moreover, data encryption used for the security and integration of network information exchanged, together with the limited access to the application data, difficulties the assessment of the service’s end-to-end (E2E) performance. In this scope, this work presents a dataset based on multiple metrics namely KQIs, which provide the E2E conditions of different services. Particularly, the dataset considers video streaming and cloud gaming (CG) services. Furthermore, a detailed description of the testbed where the dataset has been generated is given, discussing the reasoning behind the choices made for its development.&lt;/p&gt;
DNA with <i>γ</i>‐Aminopropyltriethoxysilane Switches between B‐ and C‐Form Structures under Thermal Control (2003)

A DNA thermostat: Double-stranded DNA complexed with γ-aminopropyltriethoxysilane (APTES) possesses the B-form structure at 35 °C and the C-form structure at 4 °C (see figure). Tris-(1,10-phenanthroline)ruthenium(II) specifically binds to the DNA–APTES complex at 4 °C, which suggests that the DNA structures of the DNA–APTES complex can be switched by thermal control. The DNA–APTES complex could potentially be useful for study of DNA structure as well as in novel materials for optical resolution with thermal control, thermal separation of mutagenic molecules, or thermal sensors.
Ultrafast Photochemistry of Light-Adapted and Dark-Adapted Bacteriorhodopsin: Effects of the Initial Retinal Configuration (2012)

Femtosecond spectroscopy is used to compare photochemical dynamics in light-adapted and dark-adapted bacteriorhodopsin (BR). The retinal prosthetic group is initially all-trans in the former, while it is nearly a 1:1 mixture with 13-cis in the latter. Comparing photochemistry in both serves to assess how the initial retinal configuration influences internal conversion and photoisomerization dynamics. Contrary to an earlier study, our results show that after excitation of the 13-cis form it crosses back to the ground state much more rapidly than the biologically active all-trans reactant. A similar result was recently obtained for another microbial retinal protein, Anabaena Sensory Rhodospin (ASR), which can be toggled by light between two analogous ground state configurations. Together, these studies suggest that this disparity in rates may be a general trend in the photochemistry of microbial retinal proteins. This may bear as well on the well-known enhancement in photoisomerization rates going from microbial retinal proteins to the visual pigments, as the latter also start the course of photoreception in a cis retinal configuration, in that case 11-cis. In lieu of indications for pretwisting or straining of the 13-cis retinal forms of BR and ASR, akin to those reported for rhodopsin, current results challenge many of the mechanisms held responsible for the ballistic photochemical dynamics observed in visual pigment.
A comparison of time-optimal interception trajectories for the F-8 and F-15 (1990)

The simulation results of a real time control algorithm for onboard computation of time-optimal intercept trajectories for the F-8 and F-15 aircraft are given. Due to the inherent aerodynamic and propulsion differences in the aircraft, there are major differences in their optimal trajectories. The significant difference in the two aircrafts are their flight envelopes. The F-8's optimal cruise velocity is thrust limited, while the F-15's optimal cruise velocity is at the intersection of the Mach and dynamic pressure constraint boundaries. This inherent difference necessitated the development of a proportional thrust controller for use as the F-15 approaches it's optimal cruise energy. Documented here is the application of singular perturbation theory to the trajectory optimization problem, along with a summary of the control algorithms. Numerical results for the two aircraft are compared to illustrate the performance of the minimum time algorithm, and to compute the resulting flight paths.
Efficient Earley Parsing with Regular Right-hand Sides (2010)

We present a new variant of the Earley parsing algorithm capable of efficiently supporting context-free grammars with regular right hand-sides. We present the core state-machine driven algorithm, the translation of grammars into state machines, and the reconstruction algorithm. We also include a theoretical framework for presenting the algorithm and for evaluating optimizations. Finally, we evaluate the algorithm by testing its implementation.
Predicting survival of NSCLC patients treated with immune checkpoint inhibitors: Impact and timing of immune-related adverse events and prior tyrosine kinase inhibitor therapy (2023)

Introduction Immune checkpoint inhibitors (ICIs) produce a broad spectrum of immune-related adverse events (irAEs) affecting various organ systems. While ICIs are established as a therapeutic option in non-small cell lung cancer (NSCLC) treatment, most patients receiving ICI relapse. Additionally, the role of ICIs on survival in patients receiving prior targeted tyrosine kinase inhibitor (TKI) therapy has not been well-defined. Objective To investigate the impact of irAEs, the relative time of occurrence, and prior TKI therapy to predict clinical outcomes in NSCLC patients treated with ICIs. Methods A single center retrospective cohort study identified 354 adult patients with NSCLC receiving ICI therapy between 2014 and 2018. Survival analysis utilized overall survival (OS) and real-world progression free survival (rwPFS) outcomes. Model performance matrices for predicting 1-year OS and 6-month rwPFS using linear regression baseline, optimal, and machine learning modeling approaches. Results Patients experiencing an irAE were found to have a significantly longer OS and rwPFS compared to patients who did not (median OS 25.1 vs. 11.1 months; hazard ratio [HR] 0.51, confidence interval [CI] 0.39- 0.68, P-value &amp;lt;0.001, median rwPFS 5.7 months vs. 2.3; HR 0.52, CI 0.41- 0.66, P-value &amp;lt;0.001, respectively). Patients who received TKI therapy before initiation of ICI experienced significantly shorter OS than patients without prior TKI therapy (median OS 7.6 months vs. 18.5 months; P-value &amp;lt; 0.01). After adjusting for other variables, irAEs and prior TKI therapy significantly impacted OS and rwPFS. Lastly, the performances of models implementing logistic regression and machine learning approaches were comparable in predicting 1-year OS and 6-month rwPFS. Conclusion The occurrence of irAEs, the timing of the events, and prior TKI therapy were significant predictors of survival in NSCLC patients on ICI therapy. Therefore, our study supports future prospective studies to investigate the impact of irAEs, and sequence of therapy on the survival of NSCLC patients taking ICIs.
Near-field second-harmonic imaging of thin ferroelectric films (2005)

Near-field second-harmonic generation has been investigated from unpoled polycrystalline ferroelectric thin films. Images of the second-harmonic response obtained with both $p$ and $s$ polarizations of the fundamental light display ferroelectric domain contrast due to spontaneous macroscopic electric polarization. An approach towards an absolute determination of the direction of ferroelectric polarization using analysis of the images obtained with different polarizations of the fundamental light and contrast mechanisms available for various fundamental light polarizations are discussed on a basis of a simple theoretical model.