gebhart/patrepeval huggingface dataset:
Glucosylsphingosine (Lyso-Gb1): An Informative Biomarker in the Clinical Monitoring of Patients with Gaucher Disease (2022)

Historically, disease burden and treatment responses in patients with Gaucher disease (GD) was assessed by monitoring clinical data, laboratory, imaging, chitotriosidase (CHITO), and other biomarkers; however, these biomarkers lack specificity and CHITO is uninformative in patients heterozygous or homozygous for the <i>CHIT1</i> c.1049_1072dup24 variant. Recently, glucosylsphingosine (lyso-Gb<sub>1</sub>), a sensitive and specific GD biomarker, has been recommended for patient monitoring. Furthermore, studies measuring lyso-Gb<sub>1</sub> and CHITO in patients on long-term treatment with enzyme replacement therapy (ERT) and/or substrate reduction therapy (SRT) reported as group data show a reduction in both analytes, yet individualized patient data are generally unavailable. We describe seven patients on long-term treatment with longitudinal clinical data with monitoring based on current treatment guidelines. We present four patients who exhibit stable disease with normalized CHITO despite elevated lyso-Gb<sub>1</sub>. We present one patient who transitioned from ERT to SRT due to lack of a clinical response with life-threatening thrombocytopenia who responded with marked improvement in platelets, and normalized levels of both CHITO and lyso-Gb<sub>1</sub>. Finally, we present two ERT to SRT switch patients with stable disease on ERT who exhibited non-compliance on SRT, one with mirrored marked elevations of CHITO and lyso-Gb<sub>1</sub>; and another with normal CHITO and platelets, but increasing lyso-Gb<sub>1</sub> levels and enlarged spleen. These clinical vignettes highlight the role of lyso-Gb<sub>1</sub> as a sensitive biomarker in management of patients with GD, and its further value when CHITO is normal and thus uninformative. We highlight the personalized medicine approach needed to optimize treatment outcomes and recommendations for these patients.
Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells (2023)

In this work, we extend the concept of 5-fluorouracil/heme oxygenase 1 (5-FU/HO-1) inhibitor hybrid as an effective strategy for enhancing 5-FU-based anticancer therapies. For this purpose, we designed and synthesized new mutual prodrugs, named SI 1/20 and SI 1/22, in which the two active parent drugs (i. e., 5-FU and an imidazole-based HO-1 inhibitor) were connected through an easily cleavable succinic linker. Experimental hydrolysis rate, and in silico ADMET predictions were indicative of good drug-likeness and pharmacokinetic properties. Novel hybrids significantly reduced the viability of prostate DU145 cancer cells compared to the parent compounds 5-FU and HO-1 inhibitor administered alone or in combination. Interestingly, both compounds showed statistically significant lower toxicity, than 5-FU at the same dose, against non-tumorigenic human benign prostatic hyperplasia (BPH-1) cell line. Moreover, the newly synthesized mutual prodrugs inhibited the HO-1 activity both in a cell-free model and in vitro, as well as downregulated the HO-1 expression and increased the reactive oxygen species (ROS) levels.
Propane Dehydrogenation over Alumina-Supported Iron/Phosphorus Catalysts: Structural Evolution of Iron Species Leading to High Activity and Propylene Selectivity (2016)

A series of alumina-supported Fe-based catalysts is prepared via a dry impregnation method in the presence of a phosphorus source (phosphate salt) and then used for the catalytic dehydrogenation of propane. Specifically, supported catalysts with Fe:P molar ratios of 1:1, 2:1, and 3:1 are prepared and their chemical composition, textural properties, and redox properties are characterized with an array of techniques. In the nonoxidative dehydrogenation (PDH) of propane at 600 °C and atmospheric pressure, the most active catalyst (Fe:P ratio of 3:1) exhibits 15% propane conversion and >80% C<sub>3</sub>H<sub>6</sub> selectivity. The calculated activity is 9.9 mmol/(h g<sub>Fe</sub>) (mass basis) or 13 μmol/(h m<sup>2</sup>) (surface area basis), with a corresponding TOF of 19 h<sup>–1</sup>. During the initial stages of reaction under PDH conditions, the precatalyst is reduced and Fe(0) species are generated, eventually giving way to iron carbide species. During this induction period, significant carbon is incorporated into the catalyst and propylene selectivity is low. Only after the iron carbide phase appears do the reactivity and selectivity achieve steady-state conditions with high propylene selectivity and good activity. The addition of the phosphorus source in the precatalyst is found to be important in obtaining a catalyst with superior performance.
Use of an Outbred Rat Hepacivirus Challenge Model for Design and Evaluation of Efficacy of Different Immunization Strategies for Hepatitis C Virus (2019)

A simian adenovirus vector vaccine strategy is effective at inducing complete protective immunity in the rat RHV model. The RHV Sprague-Dawley rat challenge model enables comparative testing of vaccine platforms and antigens and identification of correlates of protection and thereby provides a small animal experimental framework to guide the development of an effective vaccine for HCV in humans.
ChemInform Abstract: Ruthenium and Osmium Complexes that Bear Functional Azolate Chelates for Dye‐Sensitized Solar Cells (2015)

Abstract Review: [preparation, molecular design, structural relationship, and performance characteristics; 85 refs.
A Hybrid Approach to Nonlinear Macromodel Generation for Time-Varying Analog Circuits (2003)

Modeling frequency-dependent nonlinear characteristics of complex analog blocks and subsystems is critical for enabling efficient verification of mixed-signal system designs. Recent progress has been made for constructing such macromodels, however, their accuracy and/or efficiency can break down for certain problems, particularly those with high-Q filtering. In this paper we explore a novel hybrid approach for generating accurate analog macromodels for time-varying weakly nonlinear circuits. The combined benefits of nonlinear Pade approximations and pruning by exploitation of the system's internal structure allows us to construct nonlinear circuit models that are accurate for wide input frequency ranges, and thereby capable of modeling systems with sharp frequency selectivity. Such components are widely encountered in analog signal processing and RF applications. The efficacy of the proposed approach is demonstrated by the modeling of large time-varying nonlinear circuits that are commonly found in these application areas.
A three-phase uninterruptible power supply with an adaptive reference waveform generator (2008)

In this paper, a new digital deadbeat controller along with a modified adaptive reference signal generator are designed, implemented and applied to a three-phase series-parallel line-interactive uninterruptible power supply (UPS). This kind of UPS system provides input power factor correction, output voltage conditioning with higher efficiency compared with other kinds of UPS. It consists of a series and a parallel converter. The series converter deals with voltage-based distortions while the parallel converter cancels the current-based disturbances. The objective of the controller is to achieve deadbeat dynamic response for the parallel and series converters. The adaptive filter provides the reference signal for the load voltage and source current without any phase shift. The proposed controller adjusts the current of the parallel converter and voltage of the series converter with two and four sampling periods, respectively. Simulation and experimental results are presented, which show the viability of the proposed controller and reference signal generator for this topology.
Integration of Density Multiplication in the Formation of Device‐Oriented Structures by Directed Assembly of Block Copolymer–Homopolymer Blends (2010)

Abstract Non‐regular, device‐oriented structures can be directed to assemble on chemically nanopatterned surfaces such that the density of features in the assembled pattern is multiplied by a factor of two or more compared to the chemical pattern. By blending the block copolymers with homopolymers and designing the chemical pattern rationally, complicated structures such as bends, jogs, junctions, terminations, and combined structures are fabricated. Previously, directed assembly of block copolymers has been shown to enhance the resolution of lithographic processes for hexagonal arrays of spots and parallel lines, corresponding to the bulk morphologies of block copolymer systems, but this is the first demonstration of enhanced resolution for more complicated, device‐oriented features. This fundamental knowledge broadens the range of technologies that can be served by the directed assembly of block copolymers.
Bowel Preparation and Subsequent Colonoscopy Is Associated with the Risk of Atrial Fibrillation: A Population-Based Case-Crossover Study (2022)

This study aimed to clarify the association of the risk of atrial fibrillation (AF) with bowel preparation and subsequent colonoscopy through population-based case-crossover analysis. Patients who developed new-onset AF after undergoing colonoscopy following bowel preparation were included. For each patient, one hazard period and four control periods were matched at specified time windows. Among 189,613 patients with AF, 84 patients (mean age: 72.4 years) finally met the inclusion criteria. Most patients used polyethylene glycol (PEG)-based solutions (2 L PEG + ascorbic acid (<i>n</i> = 56), 4 L PEG (<i>n</i> = 21)) as purgatives and had hypertension (<i>n</i> = 75). A significant association of bowel preparation and colonoscopy with AF occurrence was found in all time windows. The proportion of patients with bowel preparation and colonoscopy was higher during the hazard period than during the control periods. In the 1-, 2-, 4-, 8-, and 12-week time windows, the proportions were 11.9% vs. 4.2%, 13.1% vs. 4.8%, 16.7% vs. 6.3%, 28.6% vs. 11.9%, and 29.8% vs. 14.0%, and the odd ratios (ORs) were 3.11, 3.01, 3.00, 2.96, and 2.61, respectively. Bowel preparation and undergoing colonoscopy was associated with the risk of AF and this examination need to be performed with caution especially in elderly patients with hypertension.
Understanding Individual Defects in CdTe Solar Cells: From Atomic Structure to Electrical Activity (2014)

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Two Synthetic Approaches to Ag<sub>3.4</sub>In<sub>3.7</sub>Sb<sub>76.4</sub>Te<sub>16.5</sub> Bulk Samples and their Transport Properties (2013)

Abstract Bulk samples with the chemical composition of the AIST phase‐change material Ag 3.4 In 3.7 Sb 76.4 Te 16.5 were synthesized by melt spinning as well as under high‐pressure conditions (12 GPa), respectively. Rietveld refinements as well as selected‐area electron diffraction patterns and high‐resolution transmission electron images show that both types of samples crystallize in the gray As structure type. All atoms are disordered on one Wyckoff position. The metrics of the high‐pressure sample appear compressed along [001] compared to the ones of the melt‐spun sample. This may be attributed to strain, probably caused by twinning, which relaxes at higher temperatures (starting at ca. 130 °C). The compounds decompose at 250 °C and a structural change of the Sb‐rich Sb/Te phase was observed at 440 °C. The thermoelectric properties of an annealed sample with AgInTe 2 impurities were measured and result in a ZT value of 0.003 at room temperature, which strongly increases with temperature.
Antibody prevalence and immunoglobulin IgG subclass pattern to norwalk virus in Sweden (1995)

The antibody prevalence in Sweden to Norwalk virus (NV) was investigated using a baculovirus expressed capsid antigen. One hundred thirty-two serum samples were examined for IgA, total IgG and IgG subclass antibodies to Norwalk virus. In young children, NV IgG antibody prevalence was higher than the IgA prevalence, whereas no difference was found in individuals older than 21 years. The IgG antibody prevalence was 50% in children below 5 years of age and increased to > 80% in individuals older than 10 years of age. To examine the IgG antibody response in more detail, IgG subclass patterns were characterized. IgG 1 predominated in all age groups. IgG 4, usually detected after repeated exposure to antigen, was the second most prevalent subclass, but was only found in individuals older than 21 years of age. IgG 3 subclass antibodies were found in 13% and IgG 2 in 3% of the sera examined. IgG 3 subclass antibodies have been recognized as a marker for recent or ongoing viral infections.
Intrauterine growth of triplets as estimated from liveborn birth weight data (1995)

This study was conducted to estimate intrauterine growth of triplet pregnancies from liveborn birth weights. During the years 1975-92, 109 sets of triplets were born at our hospital. Ten sets were excluded because of either major fetal anomalies or fetal death of one or more of the fetuses. The remaining 99 sets of triplets consisted of 297 newborns that were weighted immediately after birth. The mean birth weight was plotted against gestational week. The estimated intrauterine growth of triplets, in contrast to singletons, exhibited neither an acceleration phase during the third trimester, nor a flattening of the growth curve during the last few weeks of the third trimester. The mean birth weight of triplets was slightly below the 10th centile for singletons at 38 weeks' gestation or later. We conclude that the growth of triplet fetuses as estimated from liveborn birth weights is slower than that of singletons. The diagnosis of intrauterine growth retardation in triplet pregnancies should be based on growth curves to be devised for triplet pregnancies.
Towards QoS-Inferred Internet (2009)

IP networks are the federative transport networks for a large set of emerging services. These services demand hard guarantees in term of the service availability, experienced Quality of Service (QoS) and robustness. Moreover, to be able to reach customers on a large scale, most of these services should be deployed with an Inter-domain scope. In order to meet QoS requirements of these services in an interdomain context, several issues should be solved. This chapter focuses on two issues: provider-to-provider agreements and enhancements to inter-domain routing protocol to convey QoS-related information. A concept called Meta-QoS-Class is introduced together with an enriched version of Border Gateway Protocol. This chapter provides a framework suitable for the promotion of QoS-enabled services with an inter-domain scope: the Parallel Internet. This concept is a viable way for the management of IP resources so as to deliver end-to-end QoS-enabled services.
Supplementary Table 3 from Salivary Proteomics for Oral Cancer Biomarker Discovery (2023)

Supplementary Table 3 from Salivary Proteomics for Oral Cancer Biomarker Discovery
Computationally efficient cardiac views projection using 3D Convolutional Neural Networks (2017)

4D Flow is an MRI sequence which allows acquisition of 3D images of the heart. The data is typically acquired volumetrically, so it must be reformatted to generate cardiac long axis and short axis views for diagnostic interpretation. These views may be generated by placing 6 landmarks: the left and right ventricle apex, and the aortic, mitral, pulmonary, and tricuspid valves. In this paper, we propose an automatic method to localize landmarks in order to compute the cardiac views. Our approach consists of first calculating a bounding box that tightly crops the heart, followed by a landmark localization step within this bounded region. Both steps are based on a 3D extension of the recently introduced ENet. We demonstrate that the long and short axis projections computed with our automated method are of equivalent quality to projections created with landmarks placed by an experienced cardiac radiologist, based on a blinded test administered to a different cardiac radiologist.
Spectrum and Clinical Course of Visual Field Abnormalities in Ethambutol Toxicity (2016)

Visual toxicities from ethambutol are rare but represent one of the few causes of non-glaucomatous and non-compressive bitemporal hemianopsia. The authors present a six-patient case series illustrating variable clinical presentation and reversibility of visual loss in patients treated with ethambutol for <i>Mycobacterium avium</i> complex, including four patients who presented with visual field defects suggestive of bitemporal hemianopsia. Two additional patients were being followed for glaucoma, developed visual field defects with ethambutol treatment, and subsequently recovered with cessation of drug. In patients being treated with ethambutol, reversible bitemporal hemianopsia was the most commonly noted presentation of ethambutol toxicity.
Deposition of Ureido and Methacrylate Functionalities Onto Silica Nanoparticles and its Effect on the Properties of Polypropylene-Based Nanodielectrics (2021)

Surface modification of nanoparticles is often utilized to tailor the interfacial properties in dielectric nanocomposites. Introducing different functional groups to the nanoparticles’ surface may induce localized states (traps) that can enhance the dielectric performance of the material depending on their density and energy levels. Furthermore, surface modification of the filler can affect the dispersion quality and crystallization of the nanocomposites which can ultimately alter the dielectric response of the material. In this study, functionalization of silica nanoparticles is demonstrated using 3-(trimethoxysilyl)propyl methacrylate (TMPM) and 1-[3-(trimethoxysilyl)propyl]urea (TMPU) as modifying agents. The effect of such modifications on the crystallization behavior, dispersion quality of the nanoparticles, as well as charge trapping and transport under a medium DC field is studied in nanocomposites based on polypropylene (PP)/ethylene-octene-copolymer (EOC) blends at 1% and 5% of filler concentrations. The results show that both ureido and methacrylate functional groups introduce localized states, but with different energy levels. Nitrogen containing ureido groups in TMPU tend to introduce deeper traps to the filler-polymer interfaces, compared to the methacrylate silane modification. Comparing the two types of surface functionalization, the ureido-functionalized silica resulted in a suppression of space charge formation at the interfaces under a medium DC electric field, despite the relatively larger mean cluster size of nanoparticles.
Chronic type B aortic dissection in a pregnant patient managed by simultaneous thoracic endovascular aortic repair and cesarean section in the hybrid operating room (2016)

We present the case of a 50-year-old gravida with a chronic Stanford type B aortic dissection with false lumen aneurysm and discuss a literature-based treatment strategy. She underwent oocyte donation in the United States and was seen in week 15 of gestation. We chose a strategy of "watchful waiting" at a constant aortic diameter of 52 mm on magnetic resonance imaging. In week 32 + 6 days, cesarean delivery was induced in a hybrid operating room with subsequent thoracic endovascular aortic repair to reduce the risk of early dilation and rupture during the nursing period. One year later, she cared for her healthy baby with stable aortic diameters.
High Shunt Impedance Accelerating Structure with Distributed Microwave Coupling (2018)

Conventional traveling wave or pi-phase advance standing wave structures use coupling of the microwave power through the beam pipe. This feature constrains the cavity shunt impedance (efficiency) to relatively small values. As microwave power flows through the accelerating cells in such structures, the probability of breakdown in high gradient operation is greatly increased. In this paper we present results from an accelerating structure prototype with distributed microwave coupling, an approach invented at SLAC. These structures include one or more parallel waveguides which are loaded by accelerating cavities. In this configuration accelerating cavities are fed independently and completely isolated at the beam pipe. Thus there is no microwave power flow through the accelerating cavity, making this geometry favorable for high gradient operation and maximizing the shunt impedance.
Hydrodynamic flow control in marine mammals (2008)

The ability to control the flow of water around the body dictates the performance of marine mammals in the aquatic environment. Morphological specializations of marine mammals afford mechanisms for passive flow control. Aside from the design of the body, which minimizes drag, the morphology of the appendages provides hydrodynamic advantages with respect to drag, lift, thrust, and stall. The flukes of cetaceans and sirenians and flippers of pinnipeds possess geometries with flexibility, which enhance thrust production for high efficiency swimming. The pectoral flippers provide hydrodynamic lift for maneuvering. The design of the flippers is constrained by performance associated with stall. Delay of stall can be accomplished passively by modification of the flipper leading edge. Such a design is exhibited by the leading edge tubercles on the flippers of humpback whales (Megaptera novaeangliae). These novel morphological structures induce a spanwise flow field of separated vortices alternating with regions of accelerated flow. The coupled flow regions maintain areas of attached flow and delay stall to high angles of attack. The delay of stall permits enhanced turning performance with respect to both agility and maneuverability. The morphological features of marine mammals for flow control can be utilized in the biomimetic design of engineered structures for increased power production and increased efficiency.
<i>DE NOVO</i> CELL‐FREE SYNTHESIS OF HUMAN INTERFERON * (1977)

Biologically active human interferon was synthesized de novo in a cell-free mouse extract stimulated with messenger RNA from induced human fibroblasts. The identity of the antiviral activity as human interferon was demonstrated by its antigenic and species specificity. Some characteristics of the cell-free synthesis were described.
Virtual Inertia Control Methods in Islanded Microgrids (2021)

Although the deployment and integration of isolated microgrids is gaining widespread support, regulation of microgrid frequency under high penetration levels of renewable sources is still being researched. Among the numerous studies on frequency stability, one key approach is based on integrating an additional loop with virtual inertia control, designed to mimic the behavior of traditional synchronous machines. In this survey, recent works related to virtual inertia control methods in islanded microgrids are reviewed. Based on a contextual analysis of recent papers from the last decade, we attempt to better understand why certain control methods are suitable for different scenarios, the currently open theoretical and numerical challenges, and which control strategies will predominate in the following years. Some of the reviewed methods are the coefficient diagram method, H-infinity-based methods, reinforcement-learning-based methods, practical-swarm-based methods, fuzzy-logic-based methods, and model-predictive controllers.