gebhart/patrepeval huggingface dataset:
Polynucleotide analogs. 3. Synthesis, characterization, and physicochemical properties of poly(thymidylic acid) analogs (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPolynucleotide analogs. 3. Synthesis, characterization, and physicochemical properties of poly(thymidylic acid) analogsMan Jung Han, Sung Min Park, Jung Yang Park, and Sung Hwa YoonCite this: Macromolecules 1992, 25, 13, 3534–3539Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/ma00039a035https://doi.org/10.1021/ma00039a035research-articleACS PublicationsRequest reuse permissionsArticle Views58Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
BROADBAND MILLIMETERWAVE METAMATERIAL ABSORBER BASED ON EMBEDDING OF DUAL RESONATORS (2013)

Metamaterial based electromagnetic wave absorbers provide perfect absorption only over a narrow bandwidth. In this paper, broadband response is achieved through embedding of one resonator inside another in each unit cell of the metamaterial absorber lattice. These two resonators are oriented in the same direction to achieve reduced coupling between them realizing two absorption frequencies close to each other in order to broaden the effective bandwidth. The paper presents such an absorber at 77 GHz with a bandwidth of 8 GHz and peak absorption of greater than 98%. The absorber is fabricated on 125 m thin and flexible polyimide substrate by patterning gold thin film in the shape of two split ring resonators as the metamaterial unit cell. The bandwidth is enhanced by more than a factor of two compared to what could be achieved from a metamaterial with single resonator structure.
Increased Serum Copper in Primary Pulmonary Hypertension: A Possible Pathogenic Link? (1985)

In conscious sheep, we showed that intravenous infusion of copper sulfate produced a marked increase in pulmonary vascular resistance which was prevented by alpha-adrenergic blockade or catecholamine depletion. Because of these observations, we measured serum copper in 7 patients with primary pulmonary hypertension, and in 6 normal women. The 5 female patients had taken contraceptive and appetite-suppressant medication in the past. The mean serum copper level was significantly higher in patients with pulmonary hypertension, indicating that increased serum copper may be a cause or a marker of this entity.
Cager: From 3d performance capture to cage-based representation (2012)

Figure 1: CAGER Processing Pipeline. From left to right: given a raw 3D+time sequence and an initial cage, we first extract an optimal subset of positional constraints for the cage coordinate inversion. Then, the cage coordinates are inverted for each frame of the input sequence. A selective enforcement of regularization terms is defined to affect the cage vertices where the inversion is the most unstable. The resulting smoothly varying cage sequence faithfully reconstructs the input sequence when applied to a single mesh frame.
Dynamic spectrum sharing techniques for next generation networks (2013)

Summary form only given. Explosion of different types of wireless communications specifically those associated with emerging 5G networks, machine to machine (M2M) systems, personal communications and body area networks has resulted in an impending “spectrum famine”. Research is underway around the way to find solutions to this problem so that future communications needs of the world can be met. Novel approaches are being proposed to achieve this goal, ranging from techniques exploiting massive MIMO signal processing, use of small cells for high spatial reuse of the spectrum, use of highly heterogeneous networks and Dynamic Spectrum Sharing techniques where spectrum can be shared between incumbent license holders and secondary users.
Modeling the throughput of TCP Vegas (2003)

Previous analytic models of TCP Vegas throughput have been developed for loss-free (all-Vegas) networks. This work develops a simple and accurate analytic model for the throughput of a TCP Vegas bulk transfer in the presence of packet loss, as a function of average round trip time, minimum round trip time, and loss rate for the transfer. Similar models have previously been developed for TCP Reno. However, several aspects of TCP Vegas need to be treated differently than their counterparts in Reno. The proposed model captures the key innovative mechanisms that Vegas employs during slow start, congestion avoidance, and congestion recovery. The results include (1) a simple, validated model of TCP Vegas throughput that can be used for equation-based rate control of other flows such as UDP streams, (2) a simple formula to determine, from the measured packet loss rate, whether the network buffers are overcommitted and thus the TCP Vegas flow cannot reach the specified target lower threshold on throughput, (3) new insights into the design and performance of TCP Vegas, and (4) comparisons between TCP Vegas and TCP Reno including new insights regarding incremental deployment of TCP Vegas.
Figure S1. In Vivo Effects Of Oxaliplatin And Niclosamide On Mouse Motor Excitability from Niclosamide Inhibits Oxaliplatin Neurotoxicity while Improving Colorectal Cancer Therapeutic Response (2023)

&lt;p&gt;Excitability waveforms (means {plus minus} SD) were recorded at the plantar muscle in response to motor sciatic nerve stimulation of mice treated for 5 weeks with vehicle (black circles, n = 6), oxaliplatin (white circles, n = 7), oxaliplatin plus niclosamide (white squares, n = 9) or niclosamide alone (black squares, n = 7). (A) Strength-duration relationship. (B) Current-threshold relationship. (C) Threshold electrotonus in response to constant depolarizing (up) and hyperpolarizing (down) long-duration currents applied at sub-threshold intensity ({plus minus} 40%). (D) Recovery cycle. The oxaliplatin-induced effects are highlighted in grey with the corresponding parameter number beside. Note the absence of effect of oxaliplatin plus niclosamide and niclosamide alone on excitability waveforms, versus vehicle.&lt;/p&gt;
Adsorption Studies of a Microporous Phthalocyanine Network Polymer (2006)

The adsorption/desorption of N2 at 77 K and the adsorption from aqueous solution at 298 K of four organic probe molecules of different sizes (phenol, 4-nitrophenol, orange II, naphthol green B) were studied for a phthalocyanine network polymer of intrinsic microporosity (PIM) and for an activated carbon (Darco 20-40 mesh). N2 sorption analysis gave similar surface areas for the PIM and the carbon (610 and 545 m2 g(-1), respectively) but showed differences in pore size distribution, the PIM being essentially microporous (pore size < 2 nm), with a high proportion of ultramicropores (<0.7 nm), while the carbon had a broader pore size distribution, extending into the mesopore region. The carbon acted as an adsorbent for all the organic probe molecules studied, while the PIM was more selective, adsorbing the smaller molecules but rejecting the large dye naphthol green B. The PIM offers selectivity combined with a well-defined chemical structure incorporating catalytic sites.
The Influence of Warm Ischemic Time on the Viability of Deceased Organ Donor Derived Bone Marrow (2018)

It was recognized 60 years ago that deceased donor bone marrow (BM) could be a useful source of viable hematopoietic stem cells (HSCs) for transplantation. Validated procedures have since been published for the recovery of viable deceased donor HSCs and their safe use in immune tolerance clinical trials. It is the goal of Ossium Health to streamline the process of obtaining deceased donor derived BM on an industrial scale. It has been shown by previous studies that BM is tolerant to a wide range of cold and warm ischemic times during collection. CD34+ HSCs prefer a hypoxic environment and remain quiescent in vivo. This observation indicates that BM procured during routine organ and tissue recovery may remain viable for extended periods following cardiac arrest and, thus, will be suitable for transplantation. Ossium is evaluating the range of ischemia times to determine if organ and tissue donor bone marrow recovered using a standardized approach is suitable for transplantation. Vertebral bodies (VBs) and ilia of 34 deceased organ donors were recovered by Ossium's network of organ procurement organizations (OPOs) over warm ischemia times ranging from 1:03–22:03 (hr:min). Recovered VBs were then cooled and shipped overnight on wet ice to Ossium Health, Indianapolis, IN, for BM recovery using grinding and elution methods. The CD34+ HSC population was enumerated using flow cytometric ISHAGE protocols and a mean viability over the entire ischemia range was determined to be 79.3 ± 3.7% (mean ± SEM) as determined by 7‐Aminoactinomycin D (7‐AAD). While gross membrane viability is a useful measure, engraftment potential correlates strongly with functional viability as measured through colony forming unit (CFU) assay, and engraftment of transplanted units requires the presence of Granulocyte/Macrophage (GM) colonies specifically. To confirm that the deceased donor marrow would be suitable for engraftment, the CFU assay was performed and CFU‐GM were scored. Over the entire range of ischemic times, an average of 37.05 ±11.16 CFU‐GM (mean ± SEM) per 10 5 nucleated cells plated was observed. Rapid neutrophil and platelet engraftment in living donor allogeneic grafts has previously been correlated with a dose containing CFU‐GM of 5.6 per 10 5 TNC in for an average patient of 70kg. The results of this preliminary study indicate deceased donor marrow can easily meet this requirement. These data demonstrate the potential to recover viable and functional HSCs after extended periods of warm ischemia; thus, establishing the feasibility and utility of banking cells from deceased organ and tissue donors. Support or Funding Information This work was funded by a Grant from the NIH‐NIAID (1R43AI129444‐01A1, PI: Woods, EJ), and Ossium Health, Inc. This abstract is from the Experimental Biology 2018 Meeting. There is no full text article associated with this abstract published in The FASEB Journal .
Specific Blocking of CREB/DNA Binding by Cyclometalated Platinum(II) Complexes (2011)

In the groove: The unique major-groove-binding properties of a PtII complex can be used to block the interaction between the transcription factor CREB and DNA (see picture). Variation of the ligands around the PtII center changes the DNA binding mode and results in specific gene regulators with superior potency and selectivity. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
BS1 Reprogramming human macrophages with drug X: potential mechanisms for stabilisation of atherosclerotic plaques (2021)

<h3>Introduction</h3> Ischemic stroke is commonly caused by large artery atherosclerosis. Patients with a high atherosclerotic burden (stenosis) and inflamed or ulcerated plaque are at increased risk of early recurrent ischaemic events. Treatment with anti-inflammatory agents may therefore reduce stroke incidence and recurrence in patients with this condition, but in vitro human studies of the possible mechanisms are lacking. We hypothesised that an anti-inflammatory compound (denoted drug X*) alters the expression of macrophage specific genes, including scavenger receptors in in vitro models of human carotid plaque macrophages. <h3>Methods</h3> CD14+ monocytes were collected from whole blood donations (volunteers) and differentiated to monocyte derived macrophages (MDMs). Macrophage polarisation with M1 (100 ng/ml LPS + 20 ng/ml INF-γ) and M2a (20 ng/ml IL-4) markers was performed in complete media supplemented with 3 different clinically relevant concentrations of drug X. Gene expression (RT-qPCR) analysis (n=10) was carried out in the differentiated hMDMs to test for macrophage specific genes and scavenger receptors. Western Blot analysis (n=7) and immunofluorescence stain (IF) (n=5) was performed on drug X- treated MDMs to validate changes in the expression of Oxidized Low Density Lipoprotein Receptor 1 (OLR1). The physiological effect of drug X was also tested on oxLDL (25 μg/ml) uptake by macrophages (n=5). <h3>Results</h3> Our data suggest that drug X may re-program macrophages to a less inflammatory state (an M2 state) by significantly altering Mannose Receptor C-type 1 (MRC1) gene expression (p:0.0183). Drug X also alters the expression level of Macrophage Scavenger Receptor 1 (MSR1) gene, provoking the pacification of the M1 state and resulting in a beneficial effect on LDL uptake (p: 0.0845). Using OLR1 gene expression as a readout, in both M1 and M2a macrophages, the average OLR1 expression was reduced by treatment with drug X (p: 0.0003). This implies that M1 macrophages can bind less oxLDL which could reduce the formation of atherosclerotic plaque in the vessel wall. OLR1 protein expression was also reduced (p:0.0003) following 24-hour exposure of the macrophages to drug X. In functional tests, oxLDL uptake by drug X treated hMDMs was reduced by 44% (p:0.003). <h3>Conclusions</h3> The gene expression of macrophage specific genes and scavenger receptors in human M1 and M2a macrophages was significantly altered following 24-hour exposure to clinically relevant concentrations of drug X in vitro. Drug X reduced ‘active’ and pathogenic cell behaviours e.g., lipid uptake and promoted the polarisation to the M2 state. These data demonstrate that human macrophages can be reprogrammed to a less pathogenic state in vitro and they provide a potential mechanism for the effectiveness of drug X in the stabilisation of carotid atherosclerotic plaques in humans. * Drug X is used for ongoing IP/patent assessment <h3>Conflict of Interest</h3> No
Synthesis, Structures, and Reactions of Manganese Complexes Containing Diphosphine Ligands with Pendant Amines (2010)

Addition of the pendant amine ligand PNRP (PNRP = Ph2PCH2NRCH2PPh2; R = Me, Ph, n-Bu) to Mn(CO)5Br gives fac-Mn(PNRP)(CO)3Br. Photolysis of fac-Mn(PNRP)(CO)3Br with dppm [dppm = 1,2-bis(diphenylphosphino)methane] provides mixed bis(diphosphine) complexes, trans-Mn(PNRP)(dppm)(CO)(Br). Reaction of trans-Mn(PNRP)(dppm)(CO)(Br) with LiAlH4 leads to trans-Mn(PNRP)(dppm)(CO)(H), which has been characterized by crystallography. Mn(P2PhN2Bn)(dppm)(CO)(H) [P2PhN2Bn = 1,5-diphenyl-3,7-dibenzyl-1,5-diaza-3,7-diphosphacyclooctane] can be prepared in a similar manner; its structure has one chelate ring in a chair conformation and the second in a boat conformation. The boat-conformer ring directs the nitrogen of the ring toward the carbonyl ligand, and the N···C distance between one N of the P2PhN2Bn ligand and CO is 3.171(4) Å, indicating a weak interaction between the N of the pendant amine and the CO ligand. Reaction of NaBArF4 (ArF = 3,5-bis(trifluoromethyl)phenyl) with Mn(P−P)(dppm)(CO)(Br) produces the cations [Mn(P−P)(dppm)(CO)]+. The crystal structure of [Mn(PNMeP)(dppm)(CO)][BArF4] shows two very weak agostic interactions between C−H bonds on the phenyl ring and the Mn. The cationic complexes [Mn(P−P)(dppm)(CO)]+ react with H2 to form dihydrogen complexes [Mn(H2)(P−P)(dppm)(CO)]+ (Keq = 1−90 atm−1 in fluorobenzene, for a series of different P−P ligands). Similar equilibria with N2 produce [Mn(N2)(P−P)(dppm)(CO)]+ (Keq generally 1−3.5 atm−1 in fluorobenzene).
Hybrid Materials for Multiphoton Polymerization (2016)

Organic–inorganic hybrid materials are a relatively new but promising class of photopolymers used in multiphoton polymerization. Here, we present the basic principles of synthesis of hybrid materials via the sol–gel route, and describe some of the most commonly used photosensitive hybrids in multiphoton polymerization as well as some of their applications.
Novel mefloquine-based fumardiamides: synthesis and antiplasmodial evaluation (2019)

Here we report synthesis and antiplasmodial evaluation of novel mefloquine-based fumardiamides.
Heart Valve Prostheses in Pregnancy: Outcomes for Women and Their Infants (2014)

Pregnancies in women with a prosthetic heart valve demonstrate an increased risk of an adverse outcome, for both mothers and infants, compared with pregnancies in the absence of heart valve prostheses. In this contemporary population, the risk was lower than previously reported.
The space groups of axial crystals and quasicrystals (1991)

We compute all the three-dimensional quasicrystallographic space groups with $n$-fold axial point groups and standard lattices by a method that treats crystals and quasicrystals on an equal footing. We do not rely on projecting higher-dimensional crystallographic space groups, our results are valid for arbitrary $n$, and our analysis is elementary. We regard space groups as a scheme for classifying diffraction patterns to be carried out in three-dimensional reciprocal space. The familiar three-dimensional crystallographic space groups with axial point groups emerge simply and directly as special cases of the general $n$-fold three-dimensional quasicrystallographic treatment with $n=3,4,\mathrm{and} 6$. We give a general discussion of extinctions in quasicrystals and give a simple (three-dimensional) geometrical specification of the extinctions for each axial space group. The paper is intended both for people trying to systematize quasicrystal diffraction patterns and for people interested in a simple alternative approach to the computation of crystallographic or quasicrystallographic space groups.
Comparison of Aero-Elastic Simulations and Measurements Performed on NENUPHAR’s 600kW Vertical Axis Wind Turbine: Impact of the Aerodynamic Modelling Methods (2018)

International audience
Retrofitting LINAC Vaults for Compact Proton Systems—Experiences Learned (2021)

We describe the installation of the Gordon Browne Proton Therapy Center within the Lunder Building at Massachusetts General Hospital. Advances in compact proton units with modular design brought to life the vision of allocating a space in a tight corner of a fully functioning high-rise building and installing equipment via pathways typical in a hospital setting. While the assembled equipment is larger than a conventional photon therapy linear accelerator, LINAC, the proton therapy equipment was designed to be modular to make installation easier. This allowed the largest components to be lowered down an elevator shaft and transported past areas used for patient care. Issues that complicated the installation process include the sharing of the loading dock with other activities in the hospital, elevator inspections, after-hours deliveries, infection control, lay-down space, and shielding requirements. This work is important in the identification of future sites for proton therapy.
Halo Properties and Their Influence on Companion Searches at the Starfire Optical Range (1996)

One of the questions which has endured for as long as man has looked at the heavens is ”Are we alone?”. Are there beings on other planets who are also looking into the heavens? The first requirement for alien life similar to our own is that there be planets orbiting other stars. The early stages of planet formation as dictated by theory appear to be robust and several large planets have recently been detected by indirect means[1][2]. Direct imaging is currently being used to search for less ambitious, yet still scientifically interesting faint objects called Brown Dwarfs. The most convincing evidence of a Brown Dwarf, a cross between a star and a planet, was discovered by direct imaging with the aid of a 7.7 arcsecond separation from a companion star[3].
Room for interpretation (2014)

This work explores the role of communication technologies during romantic couple conflict, and the impact that self-esteem has on behavior, preferences for communication channels, and attitudes about mediated communication during conflict. Results revealed that lower levels of self-esteem and communicating via text messaging (vs. face-to-face) were associated with increased distancing and perceived partner distancing behaviors. Lower levels of self-esteem and using mediated communication were also associated with a greater likelihood of thinking that a conflict had a negative impact on the relationship. Yet, there was no evidence to suggest that individuals with lower levels of self-esteem exhibited more negative behaviors and perceptions in text-based communication than in FtF communication. In addition, lower levels of self-esteem were associated with increased use of and preferences for text-based mediated communication over FtF communication during conflict. Overall, this study suggests that both self-esteem and communication channel impact the nature of romantic couple conflict.
Nanotechnology Solutions for Global Water Challenges (2015)

The lack of clean and safe drinking water is responsible for more deaths than war, terrorism and weapons of mass destruction combined. This suggests contaminated water poses a significant threat to human health and welfare. In addition, standard water disinfection approaches such as sedimentation, filtration, and chemical or biological degradation are not fully capable of destroying emerging contaminants (e.g. pesticides, pharmaceutical waste products) or certain types of bacteria (e.g. Cryptosporidium parvum). Nanomaterials and nanotechnology based devices can potentially be employed to solve the challenges posed by various contaminants and microorganisms. Nanomaterials of different shapes, namely nanoparticles, nanotubes, nanowires and fibers have the ability to function as adsorbents and catalysts. These possess an expansive array of physicochemical characteristics deeming them highly attractive for the production of reactive media for water membrane filtration, a vital step in the production of potable water. As a result of their exceptional adsorptive capacity for water contaminants, graphene based nanomaterials have emerged as an area of significant importance in the area of membrane filtration and water treatment. In addition, Advanced Oxidation Processes (AOPs) together with or without sources of light irradiation or ultrasound, have been found to be promising alternatives for water treatment at near ambient temperature and pressure. Furthermore, the uses of visible light active titanium dioxide photocatalysts and photo-Fenton processes have shown significant potential for water purification. A wide variety of nanomaterial based sensors, for the monitoring of water quality, have also been reviewed in detail. In conclusion, the rapid and continued growth in the area of nanomaterial based devices offers significant hope for addressing future water quality challenges.