gebhart/patrepeval huggingface dataset:
B23-O-10Misfit Accommodation Mechanism of the {111} Diamond/Cubic Boron Nitride Interface (2015)

Journal Article B23-O-10 Misfit Accommodation Mechanism of the {111} Diamond/Cubic Boron Nitride Interface Get access C. L. Chen, C. L. Chen 1Advanced Institute for Materials Research, Tohoku University, Sendai, Japan chen.chunlin@wpi-aimr.tohoku.ac.jp Search for other works by this author on: Oxford Academic PubMed Google Scholar Z. C. Wang, Z. C. Wang 1Advanced Institute for Materials Research, Tohoku University, Sendai, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Kato, T. Kato 2Nanostructures Research Laboratory, Japan Fine Ceramics Center, Nagoya, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar N. Shibata, N. Shibata 3Institute of Engineering Innovation, The University of Tokyo, Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar T. Taniguchi, T. Taniguchi 4National Institute for Materials Science, Tsukuba, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Y. Ikuhara Y. Ikuhara 1Advanced Institute for Materials Research, Tohoku University, Sendai, Japan2Nanostructures Research Laboratory, Japan Fine Ceramics Center, Nagoya, Japan3Institute of Engineering Innovation, The University of Tokyo, Tokyo, Japan Search for other works by this author on: Oxford Academic PubMed Google Scholar Microscopy, Volume 64, Issue suppl_1, November 2015, Page i57, https://doi.org/10.1093/jmicro/dfv169 Published: 30 October 2015
Proceedings of the 2010 Symposium on Eye-Tracking Research & Applications (2010)

ETRA 2010 is the sixth biennial symposium in a series that has focused on all aspects of eye movement research across a wide range of disciplines. The goal of ETRA is to bring together computer scientists, engineers and behavioral scientists in support of a common vision of enhancing eye tracking research and applications. This year ETRA is being organized in conjunction with the European Communication by Gaze Interaction (http://www.cogain.org) research network that specializes in gaze-based interaction for the benefit of people with physical disabilities. To acknowledge this, the special theme of this year's symposium is Eye Tracking and Accessibility. Authors were also encouraged to submit papers including but not limited to the following areas: advances in eye tracking technology; visual attention and eye movement control; eye tracking applications; and eye tracking data analysis.

The symposium has grown to become the leading international conference in the area of research into eye tracking techniques and their applications. This year we have had more submissions than ever before from a greater number of countries. There were 58 long papers and 69 short papers submitted from 14 different countries (based on the first author only), which is the same number of countries, and almost the same list, as in 2008. We have kept the number of long papers in the conference the same as previously (18) giving an acceptance rate of 31%. This year we have rationalized the other categories of submission into just one, short papers. We have accepted 47 of these for inclusion in the conference (an acceptance rate of 68%).

The reviewing process has been improved by including 5 Area Chairs as a middle tier between the reviewers and the Program Chairs. All reviews were double-blind and all long papers were reviewed by at least 3 reviewers. All short papers which were not resubmissions of long papers were reviewed by at least 2 reviewers. Reviews of papers were prohibited from committee members where the review would present a conflict of interest. In addition the Area Chairs wrote meta-reviews of the individual reviews for each submission. 80 reviewers took part in the process and were assigned papers by the Program Chairs on the basis on their preferences and stated areas of expertise.
cdma2000 1x Rev. E Forward Link Voice Capacity (2009)

The forward link capacity of a cdma2000 lx system is power limited. Therefore, average data rate (ADR), link efficiency, and receiver signal-to-noise ratio (SNR) are the key factors for capacity improvement. In this paper, we introduce the new features of the forward fundamental channel (F-FCH) with radio configuration (RC) 11 for 1x Revision E that is being standardized at the Third Generation Partnership Project 2 (3GPP2) and advanced receivers for mobile stations (MS), targeted at these key factors. Simulations show that the new RC together with interference cancellation and a new voice codec more than doubles the forward link capacity of existing 1x systems, and more than triples the capacity with dual receive antennas. The capacity gain is achieved without any increase in voice latency or any degradation in voice quality.
Semi-empirical interconnect resistance model for advanced technology nodes: A model apt for materials selection based upon test line resistance measurements (2016)

A semi-empirical interconnect resistance model apt for fitting wire resistance data is presented. The model combines grain boundary and sidewall scattering effects with the impact of Line Edge Roughness (LER). After calibration onto experimental meander-fork structure resistance measurements, extrapolation of the model to future technology nodes reveals that for ultra-narrow line widths a better LER control will be imperative. The model is also intended for inclusion of more accurate, geometry dependent interconnect and via resistance estimators in higher abstraction level simulators, enabling a more realistic assessment of the impact of BEOL parasitics on circuit delay and power at advanced technology nodes.
<i>In vitro</i> culture and characterization of gene targeted mouse endothelium (2001)

Endothelial cells play a crucial role in maintaining cardiovascular homeostasis. Although many cardiovascular disorders involve endothelial cell dysfunction, the specific cellular and molecular mechanisms involved are not well known. We sought to establish a reproducible method of endothelial cell isolation from gene targeted mice to specifically examine endothelial pathophysiological mechanisms. Primary aortic endothelial cell cultures were established from wild type and intercellular adhesion molecule-1 (ICAM-1) deficient mice. Isolation of mouse aortic endothelial cells (MAEC) by fluorescent activated cell sorting routinely resulted in pure, homogenous, primary cultures. Wild type and ICAM-1 deficient endothelial cell morphology was similar, with both cultures showing cobblestone morphology and DiI-Ac-LDL staining. Monocyte adhesion to ICAM-1 deficient aortic endothelial cells was decreased by 86% as compared with wild type MAEC. Monocyte adhesion was also determined using YN-1, an ICAM-1 blocking antibody. YN-1 decreased monocyte adhesion to wild type aortic endothelial cells by 25%, whereas YN-1 did not further decrease monocyte adhesion to ICAM-1 deficient MAEC. These data demonstrate that gene targeted endothelial cell cultures are an effective means of identifying specific cellular and molecular mechanisms involved in endothelial cell physiology and dysfunction.
ChemInform Abstract: Zirconium‐Catalyzed Asymmetric Carbomagnesation. (1993)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Interleukin 18 gene promoter polymorphism: a link between hypertension and pre-hospital sudden cardiac death: the Helsinki Sudden Death Study (2009)

&lt;sec&gt;&lt;st&gt;Aims&lt;/st&gt; The interleukin 18 (IL-18) gene has a single nucleotide promoter region (−137) G-to-C polymorphism (rs187238) which leads to attenuated transcriptional activity of the gene and to lower production of pro-atherogenic IL-18. The C allele of this polymorphism is associated with a lower risk of sudden cardiac death (SCD). We examined the process by which this polymorphism alters the risk of SCD and coronary artery disease (CAD) by analysing the interactions between this polymorphism and environmental factors. &lt;/sec&gt; &lt;sec&gt;&lt;st&gt;Methods and results&lt;/st&gt; TaqMan 5′ nuclease assay was used to genotype the study population of the Helsinki Sudden Death Study, comprising medicolegal autopsies of 700 men. According to adjusted logistic regression analysis, there was a significant interaction between IL-18 genotype and hypertension impacting on the risk of SCD due to coronary heart disease (CHD) (&lt;it&gt;P&lt;/it&gt; = 0.011) and the severity of autopsy-verified CAD (&lt;it&gt;P&lt;/it&gt; = 0.026). Among GG homozygotes, hypertension was a major risk factor for SCD due to CHD [adjusted odds ratio (OR) 3.75 with 95% CI 1.78–7.91, &lt;it&gt;P&lt;/it&gt; &lt; 0.001] and hypertension also associated with larger coronary atherosclerotic plaque areas (&lt;it&gt;P&lt;/it&gt; = 0.002) and the occurrence of complicated plaques (adjusted OR 8.38 with 95% CI 2.39–29.33, &lt;it&gt;P&lt;/it&gt; &lt; 0.001). Among C allele carriers, hypertension was not a significant risk factor for CHD-related SCD or CAD and did not associate with the development of coronary atherosclerotic plaques. According to gene expression analysis of atherosclerotic tissue samples obtained from live patients, hypertension also interacted significantly with IL-18 genotype affecting the expression of IL-18 (&lt;it&gt;P&lt;/it&gt; = 0.030) mRNA and interferon-γ mRNA (&lt;it&gt;P&lt;/it&gt; = 0.004). &lt;/sec&gt; &lt;sec&gt;&lt;st&gt;Conclusion&lt;/st&gt; Hypertension interacts with IL-18 gene promoter −137 G/C polymorphism, affecting the risk of SCD and the development of coronary atherosclerosis. &lt;/sec&gt;
[70]PCBM and Incompletely Separated Grades of Methanofullerenes Produce Bulk Heterojunctions with Increased Robustness for Ultra-Flexible and Stretchable Electronics (2015)

An organic solar cell based on a bulk heterojunction (BHJ) of a polymer and a methanofullerene ([60]PCBM or [70]PCBM) exhibits a complex morphology that controls both its photovoltaic and mechanical compliance (robustness, flexibility, and stretchability). Methanofullerenes are excellent electron acceptors; however, they have relatively high cost and production energy (in the purest samples) compared to other small-molecule semiconductors. Moreover, [60]PCBM and [70]PCBM—typical of van der Waals solids—can be stiff and brittle. Stiffness and brittleness may lower the yield of working modules in roll-to-roll manufacturing, shorten the lifetime against mechanical failure in outdoor conditions, and jeopardize wearable and portable applications that demand stretchability or extreme flexibility. This paper tests the hypothesis that “technical grade” PCBM (incompletely separated but otherwise pure blends containing ≥ 90% [60]PCBM or [70]PCBM) could lower the cost of manufacturing organic solar cells while simultaneously increasing their mechanical stability. Measurements of the tensile modulus of five methanofullerene samples, “technical grades” and 99% grades of both [60]PCBM and [70]PCBM, and a 1:1 mixture [60]PCBM and [70]PCBM, along with their blends with regioregular poly(3-hexylthiophene) (P3HT), lead to two important conclusions: (1) films of pure [70]PCBM are approximately five times more compliant than films of pure [60]PCBM; BHJ films with [70]PCBM are also more compliant than those with [60]PCBM. (2) BHJ films comprising technical grades of [60]PCBM and [70]PCBM are approximately two to four times more compliant than are films made using 99% grades. Tensile modulus is found to be an excellent predictor of brittleness: BHJs produced with technical grade methanofullerene accommodate strains 1.4–2.2 times greater than those produced with 99% grades. The smallest range of stretchability was found for BHJs with 99% [60]PCBM (fracture at 3.5% strain), while the greatest was found for technical grade [70]PCBM (11.5% strain). Mechanical properties are correlated to the microstructures of the blended films informed from analyses of UV–vis spectra using the weakly interacting H-aggregate model. Photovoltaic measurements show that solar cells made with technical grade [70]PCBM have similar efficiencies to those made with higher-grade material but with decreased cost and increased mechanical robustness.
Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: Report of a Task Force at the 13th International Congress on Antiphospholipid Antibodies (2011)

The antiphospholipid syndrome (APS) is defined by the presence of thrombosis and/or pregnancy morbidity in combination with the persistent presence of circulating antiphospholipid antibodies: lupus anticoagulant, anticardiolipin antibodies and/or anti-β2-glycoprotein I antibodies in medium to high titers. The management of thrombosis in patients with APS is a subject of controversy. This set of recommendations is the result of an effort to produce guidelines for therapy within a group of specialist physicians in Cardiology, Neurology, Hematology, Rheumatology and Internal Medicine, with a clinical and research focus on APS.
Effects of High-Dose Microbeam Irradiation on Tumor Microvascular Function and Angiogenesis (2020)

Microbeam radiation therapy (MRT) is a form of cancer treatment in which a single large dose of radiation is spatially fractionated in-line or grid-like patterns. Preclinical studies have demonstrated that MRT is capable of eliciting high levels of tumor response while sparing normal tissue that is exposed to the same radiation field. Since a large fraction of the MRT-treated tumor is in the dose valley region that is not directly irradiated, tumor response may be driven by radiation bystander effects, which in turn elicit a microvascular response. Differential alterations in hemodynamics between the tumor and normal tissue may explain the therapeutic advantages of MRT. Direct observation of these dynamic responses presents a challenge for conventional ex vivo analysis. Furthermore, knowledge gleaned from in vitro studies of radiation bystander response has not been widely incorporated into in vivo models of tumor radiotherapy, and the biological contribution of the bystander effect within the tumor microenvironment is unknown. In this study, we employed noninvasive, serial observations of the tumor microenvironment to address the question of how tumor vasculature and HIF-1 expression are affected by microbeam radiotherapy. Tumors (approximately 4 mm in diameter) grown in a dorsal window chamber were irradiated in a single fraction using either a single, microplanar beam (300 micron wide swath) or a wide-field setup (whole-window chamber) to a total dose of 50 Gy. The tumors were optically observed daily for seven days postirradiation. Microvascular changes in the tumor and surrounding normal tissue differed greatly between the wide-field and microbeam treatments. We present evidence that these changes may be due to dissimilar spatial and temporal patterns of HIF-1 expression induced through radiation bystander effects.
Leveraging Topics and Audio Features with Multimodal Attention for Audio Visual Scene-Aware Dialog (2019)

With the recent advancements in Artificial Intelligence (AI), Intelligent Virtual Assistants (IVA) such as Alexa, Google Home, etc., have become a ubiquitous part of many homes. Currently, such IVAs are mostly audio-based, but going forward, we are witnessing a confluence of vision, speech and dialog system technologies that are enabling the IVAs to learn audio-visual groundings of utterances. This will enable agents to have conversations with users about the objects, activities and events surrounding them. In this work, we present three main architectural explorations for the Audio Visual Scene-Aware Dialog (AVSD): 1) investigating `topics' of the dialog as an important contextual feature for the conversation, 2) exploring several multimodal attention mechanisms during response generation, 3) incorporating an end-to-end audio classification ConvNet, AclNet, into our architecture. We discuss detailed analysis of the experimental results and show that our model variations outperform the baseline system presented for the AVSD task.
Enhanced muscle insulin receptor autophosphorylation with short-term aerobic exercise training (2001)

Exercise training improves insulin action in skeletal muscle, but the mechanisms of this effect are not completely understood. In particular, the role of the insulin receptor (IR) is unclear. We examined the IR and an enzyme indicative of oxidative capacity in muscle in relation to improved insulin action in 20 previously sedentary individuals before and after a 7-day program of moderate-intensity cycle ergometry. After training, insulin sensitivity increased 33% (6.20 +/- 0.91 vs. 8.22 +/- 1.12 min. microU(-1). ml(-1) mean +/- SE, pre- vs. posttraining, respectively, P < 0.05). The mitochondrial marker enzyme cytochrome c oxidase (COX) increased in vastus lateralis biopsies by 21% (P < 0.05). After training, IR autophosphorylation, determined by ELISA, was significantly increased by approximately 40% at insulin concentrations from 1 to 100 nM (P < 0.05). The training-induced improvements in IR autophosphorylation were significantly correlated with changes in muscle COX content (r = 0.65, P < 0.05). These studies indicate that, in this model of increased physical activity, improvements in IR function are an early adaptation to exercise in humans, are correlated with increases in muscle oxidative capacity, and likely contribute to the beneficial effects of exercise training on insulin action.
Editorial: Genomic Instability and Neurodegeneration (2022)

International audience
Control of Diastereoselectivity by Solvent Effects in the Addition of Grignard Reagents to Enantiopure <i>t</i>-Butylsulfinimine:  Syntheses of the Stereoisomers of the Hydroxyl Derivatives of Sibutramine (2005)

[reaction: see text] An efficient method has been developed to prepare all four isomers of the hydroxyl derivatives of sibutramine by addition of Grignard reagents (R)- or (S)-5 to a single enantiomer of sulfinyl imine (R)-1 simply by tuning the reaction solvent. The phenomenon of the reversed diastereoselectivity in CH(2)Cl(2) and THF implied that the reaction may proceed through a chelated cyclic transition state in CH(2)Cl(2) and nonchelated acyclic transition state in THF.
Prognostic significance of opioid use in the active treatment of advanced colorectal cancer (2012)

This study aimed to evaluate the oncologic significance of opioid use during active treatment for advanced colorectal cancer (CRC). The patients included in this study underwent therapeutic chemotherapy for metastatic and/or recurrent CRC. The primary outcomes measured were the characteristics of CRC patients who were administered opioid to maintain compliance with cancer treatments as well as the impact of opioid use on cancer-specific survival. Of the 245 patients, 117 (48%) were administered opioid during chemotherapy. No significant associations were detected between opioid use and clinicopathological factors, with the exception of age (<65 or ≥65 years; P= 0.0281), pathology (differentiated or undifferentiated; P= 0.0007) and response rate to chemotherapy (P= 0.0056). Patients administered opioid had significantly poorer cancer-specific survival compared to patients who did not receive opioid. The mean cancer-specific survival periods were 606±57 days (chemotherapy with opioid), <636±46 days (chemotherapy without opioid), <1140±95 days (multimodal therapy with opioid) and <1556±160 days (multimodal therapy without opioid). Additionally, oncologic emergencies due to cancer progression were significantly correlated with opioid use (P=0.0002), although no statistically significant differences were detected between the cancer-specific survival period and oncologic emergencies. The use of opioid to maintain compliance with active cancer therapy is advised in modern CRC management. However, CRC patients that were administered opioid may have potential progressive disease, thus clinicians need to be aware of the oncologic emergencies possibly arising during an active CRC therapy.
<i>Chlamydomonas</i> POLQ is necessary for CRISPR/Cas9-mediated gene targeting (2021)

The use of CRISPR/Cas endonucleases has revolutionized gene editing techniques for research on Chlamydomonas reinhardtii. To better utilize the CRISPR/Cas system, it is essential to develop a more comprehensive understanding of the DNA repair pathways involved in genome editing. In this study, we have analyzed contributions from canonical KU80/KU70-dependent nonhomologous end-joining (cNHEJ) and DNA polymerase theta (POLQ)-mediated end joining on SpCas9-mediated untemplated mutagenesis and homology-directed repair (HDR)/gene inactivation in Chlamydomonas. Using CRISPR/SpCas9 technology, we generated DNA repair-defective mutants ku80, ku70, polQ for gene targeting experiments. Our results show that untemplated repair of SpCas9-induced double strand breaks results in mutation spectra consistent with an involvement of both KU80/KU70 and POLQ. In addition, the inactivation of POLQ was found to negatively affect HDR of the inactivated paromomycin-resistant mut-aphVIII gene when donor single-stranded oligos were used. Nevertheless, mut-aphVIII was still repaired by homologous recombination in these mutants. POLQ inactivation suppressed random integration of transgenes co-transformed with the donor ssDNA. KU80 deficiency did not affect these events but instead was surprisingly found to stimulate HDR/gene inactivation. Our data suggest that in Chlamydomonas, POLQ is the main contributor to CRISPR/Cas-induced HDR and random integration of transgenes, whereas KU80/KU70 potentially plays a secondary role. We expect our results will lead to improvement of genome editing in C. reinhardtii and can be used for future development of algal biotechnology.
ChemInform Abstract: Fabrication of Mesostructured Silica Materials Through Co‐Structure‐Directing Route (2015)

Abstract Review: 104 refs.
Upright, prone, and supine spinal morphology and alignment in adolescent idiopathic scoliosis (2017)

Although there is a generalized underestimation of morphological parameters of the scoliotic deformity in the supine and prone positions as compared to the upright position, a significant correlation of these parameters is still evident among different body positions by different imaging modalities. Findings of this study suggest that severity of scoliotic deformity in AIS patients can be largely represented by different imaging modalities despite the difference in body positioning.
The STING of inflammation (INM2P.356) (2015)

Abstract Stimulator of Interferon Genes (STING, a.k.a. MPYS, TMEM173) is a critical intracellular transducer of innate immune signals induced by cytosolic DNA. Activation of STING drives both apoptosis and production of type 1 interferon (IFN1). Thus STING is a vital defensive player on the front line of innate immunity to infectious agents. Recent studies have suggested that STING may also be activated by host-derived DNA, particularly in the context of reduced nuclease activity, and could play a role in autoimmune processes. We hypothesize that during inflammation STING can be activated by host-derived DNA acting as a damage-associated molecular pattern (DAMP). To begin to address this role of STING, we utilized multiple models of in vivo sterile inflammation. Our studies demonstrate that STING-deficient animals have reduced inflammatory responses and more rapid resolution of sterile acute lung injury (ALI) and peritonitis. Further, using in vitro and in vivo models we found that STING plays a role in responses to infiltrating neutrophils and neutrophil-derived debris. Studies to be presented support a model wherein STING is activated by host-derived cellular components, such as DNA, and drives production of type 1 interferon and cell death. Ultimately this exacerbates tissue damage, driving a vicious cycle serving to amplify and perpetuate inflammation.