gebhart/patrepeval huggingface dataset:
Reaction of the vinyl methyl ether cation radical and 1,3-butadiene: a two-step cycloaddition (1984)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTReaction of the vinyl methyl ether cation radical and 1,3-butadiene: a two-step cycloadditionG. S. Groenewold and Michael L. GrossCite this: J. Am. Chem. Soc. 1984, 106, 22, 6575–6579Publication Date (Print):October 1, 1984Publication History Published online1 May 2002Published inissue 1 October 1984https://pubs.acs.org/doi/10.1021/ja00334a020https://doi.org/10.1021/ja00334a020research-articleACS PublicationsRequest reuse permissionsArticle Views127Altmetric-Citations29LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
MiTAP for Bio-Security: A Case Study (2002)

Abstract : MiTAP (MITRE Text and Audio Processing) is a prototype system available for monitoring infectious disease outbreaks and other global events. MiTAP focuses on providing timely, multi-lingual, global information access to medical experts and individuals involved in humanitarian assistance and relief work. Multiple information sources in multiple languages are automatically captured, filtered, translated, summarized, and categorized by disease, region, information source, person, and organization. Critical information is automatically extracted and tagged to facilitate browsing, searching, and sorting. The system supports shared situational awareness through collaboration, allowing users to submit other articles for processing, annotate existing documents, post directly to the system, and flag messages for others to see. MiTAP currently stores over one million articles and processes an additional 2000 to 10,000 daily, delivering up-to-date information to dozens of regular users.
Atividade Antibacteriana e Propriedades Físico-Químicas de um Cimento Resinoso Contendo Compostos à Base de Óleo de Copaíba (2018)

O objetivo deste estudo foi avaliar as propriedades físico-químicas e antimicrobianas de um cimento endodontico resinoso contendo óleo de copaíba. Os cimentos foram formulados em três concentrações do óleo (0,5%, 1% e 2%). O grupo de controle negativo foi um cimento sem óleo e o comercial Real Seal® (Sybronendo, Orange, EUA). O controle positivo foi o inóculo bacteriano. A atividade antimicrobiana foi avaliada através da determinação da concentração inibitória mínima (MIC) e frente aos testes de contato direto (TCD). Para avaliar as propriedades físico-químicas foram realizados os ensaios de escoamento, alteração dimensional, tempo de presa e radiopacidade, estabelecidos de acordo com a norma ISO 6876. O grau de conversão foi medido por espectroscopia no infravermelho médio por transformada de Fourier (FTIR). Para o MIC, os resultados contra S. aureus foram de 19,53 µg/ml e os demais foram de 4,88 µg/ml. No TCD, o cimento contendo 0,5% de óleo de copaíba apresentou o maior efeito antimicrobiano em 24h contra E. faecalis, no teste contra S. aureus os cimentos contendo o oleo são superiores ao comercial em 24h. O escoamento e a alteração dimensional foram semelhantes ao cimento comercial, o tempo de presa e grau de conversão foram maior do que o comercial, somente a radiopacidade obteve resultado inferior. Logo, os cimentos contendo óleo de copaíba revelaram atividade antimicrobiana em 24h em todas as concentrações testadas. Em especial, o cimento contendo 0,5% de copaíba. No entanto, é necessário o ajuste da radiopacidade, porque não estava de acordo com a norma ISO 6876.Palavras-chave: Obturação do Canal Radicular. Cimentos de Resina. Atividade Antimicrobiana.
IL-33 promotes type 1 cytokine expression via p38 MAPK in human NK cells (2020)

This study tests the hypothesis that activation of MAPK by physiologically relevant concentrations of IL-33 contributes to enhanced cytokine expression by IL-12 stimulated human NK cells. While IL-33 canonically triggers type 2 cytokine responses, this cytokine can also synergize with type 1 cytokines like IL-12 to provoke IFN-γ. We show that picogram concentrations of IL-12 and IL-33 are sufficient to promote robust secretion of IFN-γ by human NK cells that greatly exceeds resposes to either cytokine alone. Nanogram doses of IL-33, potentially consistent with levels in tissue microenvironments, synergize with IL-12 to induce secretion of additional cytokines, including TNF and GM-CSF. IL-33-induced activation of the p38 MAPK pathway in human NK cells is crucial for enhanced release of IFN-γ and TNF in response to IL-12. Mechanistically, IL-33-induced p38 MAPK signaling enhances stability of IFNG transcripts and triggers A disintegrin and metalloproteinase domain 17 (ADAM17) mediated cleavage of TNF from the cell surface. These data support our hypothesis and suggest that altered sensitivity of NK cells to IL-12 in the presence of IL-33 may have important consequences in diseases associated with mixed cytokine milieus, like asthma and chronic obstructive pulmonary disease.
A population genetic framework for the study of invasive diseases caused by serotype b strains of Haemophilus influenzae. (1985)

One hundred seventy-seven isolates of serotype b Haemophilus influenzae recovered largely from children with invasive disease in the United States were characterized by the electrophoretic mobilities of 16 metabolic enzymes, the NaDodSO4/PAGE pattern of outer-membrane proteins (OMP), and biotype. Thirty-two distinctive multilocus genotypes (electrophoretic types, ETs) were distinguished on the basis of allele profiles at the enzyme loci. Twenty-eight OMP types and five biotypes were identified, but only 55 distinctive combinations of ET, OMP type, and biotype were represented. The strong nonrandom associations of characters and the recovery of isolates with identical properties in widely separated geographic regions and over a 40-year period suggest that the population structure of H. influenzae is basically clonal. Examination of nonserotype b isolates indicated that clones of serotype b are a restricted subset of the genotypes in the species as a whole. Currently, most of the invasive H. influenzae disease in the United States is caused by serotype b strains of two related ETs, and, more specifically, much of it is attributable to two subclones marked by OMP type. There is evidence that the frequency of the ET-1/OMP 1H/biotype I subclone has increased dramatically in the United States since the 1939-1954 period. The hypothesis that populations of H. influenzae are subject to marked temporal variation in clonal composition is supported by evidence of major differences in the genetic structure of populations in the United States and the Netherlands.
Structured-Glass Waveguide Technology for High-Performance Millimetre-Wave Components and Systems (2022)

This work presents a novel waveguide medium based on laser-induced structured-glass for the design of high-end millimetre-wave components and systems. The material properties, fabrication process and functional attributes of the structured-glass technology are first described and then applied in order to demonstrate a fourth-order bandpass filter prototype operating within the W-band frequency range, centered around 88 GHz with a narrow fractional bandwidth of 2.3&#x0025;. The basic filter design, dimensional considerations, and assembly process are discussed in order to outline the fabrication process. The prototype filter, along with its associated feed-line transitions and split-block interface are measured and characterized in the laboratory in order to validate the design approach. The measured response is shown to be exceptionally accurate; the insertion loss is found to be approximately 1.43 dB - 1.97 dB throughout the measured passband with a return loss of better than 22 dB and center-frequency offset of approximately 0.117&#x0025;. A comparison to existing technologies is discussed in order to highlight the advantages of the proposed medium and to contrast the differences in both manufacture and achievable results for high-end components.
ChemInform Abstract: FUNCTIONAL PHOSPHINES: A NEW SYNTHESIS OF DIPHENYLPHOSPHINOACETONITRILE AND ETHYL DIPHENYLPHOSPHINOACETATE; SOME OF THEIR COMPLEXES WITH IRON(0), GOLD(I), NICKEL(II), PALLADIUM(II), PLATINUM(II), RHODIUM(III), AND IRIDIUM(III). STEREODYNAMIC BEHAVIOR (1978)

Abstract Um zu untersuchen, ob die Koordinationseigenschaften von Phosphor durch funktionelle Substituenten sich ändern würd 126 unter welchen Bedingungen es möglich wäre, Bindungs‐Wechselwirkungen zwischen der funktionellen Gruppe und dem Übergangsmetall zu erhalten und ob Aktivierung der benachbarten Methylengruppe zu beobachten wäre, wurden die Titelverbindungen (III) dargestellt.
Phase I study of tirabrutinib (<scp>ONO</scp>‐4059/<scp>GS</scp>‐4059) in patients with relapsed or refractory B‐cell malignancies in Japan (2019)

We evaluated the safety, efficacy, pharmacokinetics, pharmacodynamics and predictive biomarkers of tirabrutinib, a second-generation, enhanced-selectivity Bruton's tyrosine kinase inhibitor in Japanese patients with relapsed/refractory B-cell non-Hodgkin lymphoma (B-cell NHL) and chronic lymphocytic leukemia (CLL). This was an open-label, multicenter, phase I study. Seventeen patients (male N = 8) with a median age of 70 years were enrolled in 4 dose cohorts (160 mg once daily [N = 3], 320 mg once daily [N = 3], 480 mg once daily [N = 4] and 300 mg twice daily [N = 7]); 4 patients had continued tirabrutinib administration as of 4 January 2018. The maximum tolerated dose was not reached. Pneumonitis (N = 1) was the dose-limiting toxicity for 300 mg twice daily. Common adverse events (AEs) were rash (35.3%) and vomiting (29.4%). Eight patients (47.1%) developed grade ≥3 AEs: neutropenia (23.5%), anemia (11.8%) and leukopenia (11.8%) were frequent. The overall response rate (≥PR) was 76.5% (13/17 patients), including 4 DLBCL patients with no CD79A/B or MYD88 mutations, and 1 CLL patient with a TP53 mutation, providing promising data for future developments. Of 16 patients with measurable lesions during the screening period, 12 showed ≥50% reductions in tumor diameter. In many patients, the tumor size decreased soon after beginning treatment. The maximum serum concentration for tirabrutinib was 611, 1220, 1280 and 886 ng/mL on Day 1 and 484, 971 1940, and 961 ng/mL on Day 28 for Cohorts 1-4, respectively. Tirabrutinib pharmacokinetics were linear, with little accumulation following multiple doses. Tirabrutinib was well tolerated and showed promising efficacy for B-cell NHL/CLL.
Low overhead correction scheme for unreliable LDPC buffering (2013)

Aggressive voltage overscaling (VOS) has been recently adopted to reduce the power consumption of embedded memories. While this affects reliability, several techniques have been developed to achieve reliable operation under aggressive VOS. In this paper, we present a comprehensive power-performance study of LDPC decoders enabling aggressive VOS to internal memories. We propose a correction scheme based on defect map insertion that maintains reliable LDPC decoder under aggressive VOS. The proposed scheme maintains the LDPC decoder performance while achieving a power saving of up to 21%.
Proceedings of the 7th symposium on Operating systems design and implementation (2006)

We are very happy to welcome you to Seattle for the 7th USENIX OSDI conference. Nearly twelve years ago, OSDI was conceived as the off-year SOSP. OSDI has always tried to attract and publish papers of the same depth and quality as those found in SOSP, but with somewhat more emphasis on implementation. We would like to think that OSDI is no longer a fill-in between SOSPs, but a true peer. You (and time) will tell whether OSDI has achieved that, but here we will say a little about how we ran the OSDI '06 process in support of this goal.

OSDI '06 received 155 submissions. The Call for Papers gave specific instructions for paper length and format. We asked six authors to withdraw their papers due to substantial non-compliance with these requirements, out of fairness to those authors who did follow the rules.

The remaining papers were reviewed in two rounds. In the first round, each paper received full reviews by three PC members, and many were also reviewed by an external reviewer. Based on the first-round reviews, the PC promoted 87 papers to the second round. Second-round papers received at least two additional full reviews by PC members, and many received additional PC or external reviews. This meant that every paper discussed at the PC meeting had been reviewed by at least five PC members. In all, we generated 697 reviews, most of them quite detailed.

We accepted 27 of the 149 submissions, about 18%; this is in line with the historical average for OSDI, and consistent with the top conferences in the field. As traditional for OSDI, we assigned a PC member to shepherd each accepted paper.

We allowed PC members to submit papers, but we judged these very carefully. Of the five papers submitted by PC members, we accepted just one.

As program chairs, we were sensitive to the accusation that systems conferences often default to accepting papers that are clearly correct, yet boring; this leads to conferences short in novelty, and controversy. Consequently, we nudged the OSDI reviewers to favor but flawed submissions over but correct ones, as long as the flaws were minor and likely fixable. Reviewers assigned scores on a scale of 1--5 for quality, excitement, and quality.

After the program was set, we created scatter plots showing the relationship between these metrics and the final outcomes. Figure 1 shows that boring papers tended to not make it past the first round, but that exciting papers, even imperfect ones, tended to end up in the conference. Nevertheless, we ultimately rejected some highexcitement papers because we were not satisfied with their technical quality.

Presentation quality also turned out (not surprisingly) to be an excellent predictor of acceptance. Most of the papers that were highly ranked in terms of presentation were ultimately accepted as shown in Figure 2. Good writing improves the reviewers' understanding of the technical content, and makes it easier to appreciate the authors' own excitement.
Application of Microalloyed Steels to Achieve High Toughness in Hot Forged Components without Further Heat Treatments (1986)

&lt;div class="htmlview paragraph"&gt;Automotive parts produced by cold or hot forging steel bars are often heat treated after forging to reduce their grain size and obtain improvements in mechanical properties such as tensile, impact and fatigue properties. If heat treatments after forging can be eliminated, savings in energy and handling costs could be realised.&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;Although rolling and cold drawing without additional heat treatments have been already used, hot forged components have not except a few applications because of low toughness properties when heat treating after forging is omitted. Tests in our laboratory have shown that the toughness and other mechanical properties of hot forged parts can be significantly improved without the use of post heat treatments. Results were as follows: &lt;ol class="list nostyle"&gt; &lt;li class="list-item"&gt;&lt;span class="li-label"&gt;1.&lt;/span&gt; &lt;div class="htmlview paragraph"&gt;High strength and high toughness are obtained by decreasing carbon contents, increasing manganese, adding both of microalloying elements (V, Ti).&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;span class="li-label"&gt;2.&lt;/span&gt; &lt;div class="htmlview paragraph"&gt;Nitrogen (N) addition may be required but the amount depends on V and Ti contents present. The fatigue properties are affected by the presence of nitride precipitates.&lt;/div&gt;&lt;/li&gt; &lt;li class="list-item"&gt;&lt;span class="li-label"&gt;3.&lt;/span&gt; &lt;div class="htmlview paragraph"&gt;Forging temperature and cooling rates after forging must be controlled to insure uniform properties throughout the finished component.&lt;/div&gt;&lt;/li&gt; &lt;/ol&gt;&lt;/div&gt; &lt;div class="htmlview paragraph"&gt;By using the compositional and forging controls, automotive parts that were hot forged and air cooled had properties equivalent to those of the previous parts that were hot forged and subsequently heat treated.&lt;/div&gt;
Facile dimethylarsenic exchange and pyramidal inversion in its cysteine and glutathione adducts (2013)

Rapid thiolate exchange of dimethylarsonium, Me2As(+), is observed between two different thiolate species in solution. NMR is used to characterize the equilibrium constants for interthiol transfer as well the rapid intra molecular conformational dynamics which leads to the coalescence of diastereotopic methyl resonances. These rapid exchange kinetics have important consequences of arsenic's toxicity and pharmacology.
Using Steel Slag for Dissolved Phosphorus Removal: Insights from a Designed Flow-Through Laboratory Experimental Structure (2020)

Steel slag, a byproduct of the steel making process, has been adopted as a material to reduce non-point phosphorus (P) losses from agricultural land. Although substantial studies have been conducted on characterizing P removed by steel slag, few data are available on the removal of P under different conditions of P input, slag mass, and retention time (RT). The objective of this study was to investigate P removal efficiency as impacted by slag mass and RT at different physical locations through a horizontal steel slag column. Downstream slag segments were more efficient at removing P than upstream segments because they were exposed to more favorable conditions for calcium phosphate precipitation, specifically higher Ca2+ concentrations and pH. These results showed that P is removed in a moving front as Ca2+ and slag pH buffer capacity are consumed. In agreement with the calcium phosphate precipitation mechanism shown in previous studies, an increase in RT increased P removal, resulting in an estimated removal capacity of 61 mg kg−1 at a RT of 30 min. Results emphasized the importance of designing field scale structures with sufficient RT to accommodate the formation of calcium phosphate.
Langlois Reagent: An Efficient Trifluoromethylation Reagent (2023)

Abstract
Modeling and Optimization of a Linear Actuator for a Two-Stage Valve Tappet in an Automotive Engine (2014)

This paper focuses on external volume and power consumption optimization of an electromagnetic actuator used to move pins in a two-stage variable valve lift component within an automotive engine. This system is designed to change the valve lift at each engine cycle. To achieve this optimization, three models were developed: a magnetic, an electric, and a dynamic model. They evaluate the performances of a given actuator, check if it fulfills its role, and define the springs needed for the displacement of the pins. The optimization is made using a particle swarm method and can reduce the volume up to 20% with the same electric consumption.
Optimisation d'un code de phase robuste aux phénomènes d'éclipse (2019)

International audience
Supplementary Table S1 from Genomic Instability and Protumoral Inflammation Are Associated with Primary Resistance to Anti–PD-1 + Antiangiogenesis in Malignant Pleural Mesothelioma (2023)

&lt;p&gt;Baseline characteristics of the patients treated.&lt;/p&gt;
ChemInform Abstract: Characterization of a Novel μ4‐Peroxide Tetrairon Unit of Possible Relevance to Intermediates in Metal‐Catalyzed Oxidations of Water to Dioxygen. (1989)

Abstract The complex (II) is prepared by ligand substitution from (I) and can also be obtained from a MeCN solution of (NEt 4 ) 2 ‐(Fe2OCl6) and Zn benzoate and H 2 O 2 with 84% yield.
Changes in Lactate-Producing and Lactate-Utilizing Bacteria in Relation to pH in the Rumen of Sheep During Stepwise Adaptation to a High-Concentrate Diet (1979)

Changes in the numbers and types of lactate-producing and lactate-utilizing bacteria in the rumen of sheep were followed during stepwise adaptation from a low- to a high-concentrate diet. The mean numbers of bacteria increased after each change in diet when increasing amounts of maize grain were substituted for maize stover. A surge in number of amylolytic bacteria always preceded an increase in lactate-utilizing bacteria, and with the final diet containing 71% grain and molasses the two groups tended to balance each other, which resulted in low lactic acid accumulation. The lactate utilizers thus played a key role in controlling the fermentation. Orderly shifts occurred among the predominating amylolytic and lactate-utilizing bacteria in response to the gradual decrease in ruminal pH as the amount of maize meal in the diet increased. Among the lactate utilizers, the succession began with acid-sensitive Veillonella and Selenomonas, which were superseded by more acid-tolerant Anaerovibrio and Propionibacterium. Among the amylolytic bacteria, Bacteroides was superseded by more acid-tolerant Lactobacillus and Eubacterium. The ecological succession of predominating genera was shown to be correlated significantly with ruminal pH and, more specifically, with the length of time as well as the extent to which the pH remained below a certain critical undefined value in the rumen, arbitrarily set at pH 6.00.
High-performance GaInNAsSb/GaAs lasers at 1.5 um (2005)

We achieved 1.5-um CW SQW GaInNAsSb lasers with GaNAs barriers grown by MBE on GaAs substrates with typical room temperature threshold densities below 600A/cm<sup>2</sup>, external quantum efficiencies above 50%, and output powers exceeding 200mW from both facets for 20x1222um devices tested epitaxial-side up. In pulsed mode, 450A/cm<sup>2</sup>, 50%, and 1100mW were realized. Longer devices yielded over 425mW of total CW power and thresholds below 450A/cm<sup>2</sup>. These results are comparable to high quality GaInNAs/GaAs lasers at 1.3um. Z-parameter measurements revealed that these improvements in the performance metrics of approximately 40-60% over previous results are primarily due to reduced monomolecular recombination. The large differential gain of GaInNAsSb/GaNAs/GaAs lasers at 1.5um of approximately 1.2x10-15cm<sup>2</sup> was mostly squandered in previous devices due to large quantities of monomolecular recombination. The characteristic temperatures for threshold current, T0, and for efficiency, T1, were 66K and 132K, respectively. These reduced values, compared to prior measurements of 106K and 208K, respectively, indicate carrier leakage. Since monomolecular recombination is temperature insensitive, the temperature stability of device operation was adversely affected.
Capture of Periodate in a {W<sub>18</sub>O<sub>54</sub>} Cluster Cage Yielding a Catalytically Active Polyoxometalate [H<sub>3</sub>W<sub>18</sub>O<sub>56</sub>(IO<sub>6</sub>)]<sup>6−</sup> Embedded with High‐Valent Iodine (2008)

Periodat im Zentrum: Ein Wolframperiodatcluster der Form β*-[H3W18O56(IO6)]6−, in dem Periodat in einen {W18O54}-Käfig eingeschlossen ist, konnte als erstes [HnW18O56(XO6)]m−-Heteropolyoxowolframat kristallographisch charakterisiert werden. Massenspektrometrische, elektrochemische und Katalysestudien sowie DFT-Rechnungen offenbaren die ungewöhnlichen physikalischen Eigenschaften der Clusterstruktur, die auch in Lösung intakt bleibt.