gebhart/patrepeval huggingface dataset:
Superballistic transport in hybrid photonic lattices (2013)

Wave transport in time-independent potentials is formally divided into two major categories depending on how the second moment of the evolving excitation grows with “time”. If translational symmetry is present, the eigenmodes of the system are plane waves or Floquet-Bloch modes [1], and the variance of an initially localized excitation increases quadratically in time (ballistic spreading). On the other hand, since the pioneering work of Anderson [2], it is known that disorder (at least in one-dimension) tends to suppress propagation and leads to localization [3]. In all cases, however, it is believed that the wave packet spreading is bounded in all times by that of a ballistic growth.
A multicolor multiplex lateral flow assay for high-sensitivity analyte detection using persistent luminescent nanophosphors (2019)

Incorporating two persistent luminescent nanophosphors (PLNPs), green-emitting SrAl<sub>2</sub>O<sub>4</sub>:Eu<sup>2+</sup>,Dy<sup>3+</sup> (SAO) and blue-emitting (Sr<sub>0.625</sub>Ba<sub>0.375</sub>)<sub>2</sub>MgSi<sub>2</sub>O<sub>7</sub>:Eu<sup>2+</sup>,Dy<sup>3+</sup> (SBMSO), in a single lateral flow assay (LFA) establishes a luminescence-based, multiplex point-of-need test capable of simultaneously detecting two different analytes in a single sample. The advantages of this system are the high sensitivity and photostability of PLNPs, while only requiring access to minimal hardware and a smartphone for signal detection. The PLNPs were obtained by first wet milling bulk synthesized phosphor powders, followed by fractionation using differential centrifugal sedimentation to obtain monodisperse nanoparticles. A modified Stöber process was then employed to encapsulate the nanoparticles in a water-stable silica shell followed by attaching antibodies to the particles' surfaces using reductive amination chemistry. The resulting PLNPs were incorporated in an LFA to concurrently detect two independent model analytes, prostate-specific antigen (PSA) and human chorionic gonadotropin (hCG). The multicolor-multiplex PLNP-based assays were finally imaged using a smartphone-based imaging system with excellent detection limits (0.1 ng mL<sup>-1</sup> of PSA and 1 ng mL<sup>-1</sup> of hCG) that are competitive with commercially available LFAs.
Continuous wave laser ignition thresholds of coal dust clouds (2003)

Laser-based instruments are used in areas where coal dust ignition presents a safety hazard. The National Institute for Occupational Safety and Health, Pittsburgh Research Laboratory (NIOSH, PRL) is conducting a study to help determine when an optical beam may be considered a potential ignition source in underground coal mines or coal storage facilities. Researchers conducted experiments to determine threshold igniting powers for Pittsburgh seam bituminous coal dust clouds using an 803 nm continuous wave laser. For fine sized coal dust dispersed in air, concentrations ranging from 600 to 2000 g/m3 were the most easily ignited. A heated layer of coal dust that deposited on the fiber tip during dispersion ignited the dust clouds. Minimum observed igniting powers for laser beams delivered by 200, 400, and 800 μm core fiber optic cables and directed into coal dust clouds were 2.0, 3.0, and 5.0 W, respectively. Threshold igniting power was proportional to beam diameter, and threshold igniting power density decreased with larger fiber diameters. Ignition delay times averaged 0.6 s and did not vary significantly with laser power under initially turbulent test conditions and with flammable targets. Comparisons are made with the results of other researchers.
Abstract 6213: Extracellular vesicles <i>MDM2</i>-DNA derived from dedifferentiated liposarcoma induces MMP2 production from preadipocytes (2020)

Abstract Dedifferentiated liposarcoma (DDLPS) is molecularly characterized by wt p53 and MDM2 gene amplification causing MDM2 protein over-production, the key oncogenic process in DDLPS. Commonly located in fat-bearing retroperitoneal areas, almost 60% of DDLPS patients undergo multifocal recurrence, typically amenable to palliative treatment only, and occasionally develop distant metastasis. These factors lead to an abysmal 10% 10 year overall survival rate. Tumor cell-derived extracellular vesicles (EVs) can facilitate loco-regional malignancy dissemination by depositing molecular factors that participate in the development of pre-metastatic niches for tumor cell implantation and growth. High number of MDM2 DNA molecules was identified within EVs from DDLPS patient serum (ROC vs normal; 0.95) as well as from DDLPS cell lines. This MDM2 DNA could be transferred to preadipocytes (P-a), a major and ubiquitous cellular component of the DDLPS tumor microenvironment (TME), with subsequent P-a production of matrix metalloproteinase 2 (MMP2), a critical component in the metastatic cascade. Since multifocal loco-regional DDLPS spreading is the main cause of the remarkably high lethality of this disease, a better understanding of the underlying oncogenic processes and their regulatory mechanisms is essential to improve the outcome of this devastating disease. Citation Format: Lucia Casadei, Federica Calore, Ameya Deshmukh, Abeba Zewdu, Paolo Fadda, Danielle Braggio, Martin Wabitsch, Carlo M. Croce, Dina Lev, Raphael Pollock. Extracellular vesicles MDM2-DNA derived from dedifferentiated liposarcoma induces MMP2 production from preadipocytes [abstract]. In: Proceedings of the Annual Meeting of the American Association for Cancer Research 2020; 2020 Apr 27-28 and Jun 22-24. Philadelphia (PA): AACR; Cancer Res 2020;80(16 Suppl):Abstract nr 6213.
Event-based use conditions method for thermo-mechanical reliability risk assessment (2014)

The traditional approach of thermo-mechanical (T-M) reliability modeling is based on power cycle events. This approach is not useful for products which are rarely powered down, because power cycles alone do not capture all the reliability stress from temperature variation over these products' use life. This paper describes a methodology to determine the temperature cycle requirements for products like smartphones and tablets which accounts for the temperature variation associated with usage events, which we call “mini-cycles”. The T-M model is based on the distribution of individual users' histories as a series of events over time, which is then translated into a temperature vs. time trace for each user. These temperature traces are then used as the main inputs to T-M models, for example using the Norris-Landzberg (N-L) acceleration model to evaluate solder damage for each user. Results are summarized in a distribution of T-M damage across all users. This new methodology improves the understanding of thermo-mechanical reliability requirements due to the impact of “mini-cycles”.
Broadband group velocity anomaly in transmission through a photonic crystal slab (2006)

We have observed an anomalous group velocity effect for transmission perpendicular to a photonic crystal slab. This is a surprisingly broadband phenomenon, with Dw/w ≫ 50%. Our results are consistent with FDTD simulations.
New Analogs of Trimethoprim (1982)

Possible goals and recent developments in the field of antimicrobial 2,4-diamino-5-benzylpyrimidines are discussed. Three analogs of trimethoprim--all bearing different substituents at position 4 of the benzyl moiety and one also having the methoxy groups replaced by ethoxy substituents--are characterized in some detail. These analogs exhibit physicochemical properties different from those of trimethoprim and are potent inhibitors of several dihydrofolate reductases. Because they differ from trimethoprim in lipophilicity, their in vitro activity, spectrum of activity, and pharmacokinetic properties also differ from those of trimethoprim. These differences are judged to be the reason for enhanced in vivo efficacy against several experimental infections. Distinct pharmacokinetic differences observed in dogs include a longer elimination half-life and a larger volume of distribution. These favorable properties indicate the potential value of further studies in humans.
Studies on nonoxynol-9. IV. Biochemical and morphological effects in the liver, kidneys and lungs of rats following intravaginal and intraperitoneal administration. (1987)

The content of DNA and collagen was significantly increased in the liver of young adult rats injected intraperitoneally for five consecutive days with Nonoxynol-9 (N-9; 5 mg/100 g). No changes were observed in the lung. A single dose of N-9 increased the activity of SGOT, reaching a maximum 4 to 8 hours after injection. In transmission electron microscopy the hepatocytes showed a dramatic increase of the rough endoplasmic reticulum. Rats injected intravaginally 5 mg/100 g of N-9 daily demonstrated after 15 injections a significant increase of collagen in the liver and kidney. After 15 days, DNA was significantly increased in the kidney. SGOT increased after 5 applications of N-9. Light and electron microscopy of the liver showed signs of nonspecific inflammation. We conclude that N-9 administered to young adult rats intravaginally or intraperitoneally induces biochemical and morphological changes in organs involved in the excretion of this detergent.
Urinary collagen degradation products as early markers of progressive renal fibrosis (2017)

These data displayed urinary collagen breakdown products as sensitive early markers of interstitial fibrosis, preceding histological fibrotic changes, which might replace the invasive renal biopsy procedure to assess fibrosis. Anti-fibrotic FTY720 intervention reduced some fibrotic markers without affecting collagen type III metabolism.
Reduced Follicular Regulatory T Cells in Spleen and Pancreatic Lymph Nodes of Patients With Type 1 Diabetes (2021)

In the attempt to understand the origin of autoantibody (AAb) production in patients with and at-risk for T1D, multiple studies have analyzed and reported alterations in follicular helper T cells (Tfh) in presymptomatic AAb-positive subjects and patients with T1D. Yet, it is still not clear whether the regulatory counterpart of Tfh cells, represented by follicular regulatory T cells (Tfr), is similarly altered. To address this question, we performed analyses in peripheral blood, spleen and pancreatic lymph nodes (PLN) of organ donor subjects with T1D. Blood analyses were also performed in living AAb-negative and -positive subjects. While negligible differences in the frequency and phenotype of blood Tfr cells were observed between T1D, AAb-negative and AAb-positive adult subjects, the frequency of Tfr cells was significantly reduced in spleen and PLN of T1D as compared to non-diabetic controls. Furthermore, adoptive transfer of Tfr cells delayed disease development in a mouse model of T1D, a finding that could indicate that Tfr cells play an important role in peripheral tolerance and regulation of autoreactive Tfh cells. Together, our findings provide evidence of Tfr cell alterations within disease-relevant tissues in patients with T1D suggesting a role for Tfr cells in defective humoral tolerance and disease pathogenesis.
Complete Genome Sequence of the Feline Calicivirus 2280 Strain from the American Tissue Culture Collection (2013)

Feline calicivirus (FCV) is a highly contagious pathogen of cats that can be grown in cultured cells. FCV is used as a model to study nonculturable caliciviruses, such as noroviruses. We determined the complete genome sequence of the FCV 2280 strain from the American Tissue Culture Collection.
Chemical Toolkit for PARK7: Potent, Selective, and High-Throughput (2022)

The multifunctional human Parkinson's disease protein 7 (PARK7/DJ1) is an attractive therapeutic target due to its link with early-onset Parkinson's disease, upregulation in various cancers, and contribution to chemoresistance. However, only a few compounds have been identified to bind PARK7 due to the lack of a dedicated chemical toolbox. We report the creation of such a toolbox and showcase the application of each of its components. The selective PARK7 submicromolar inhibitor with a cyanimide reactive group covalently modifies the active site Cys106. Installment of different dyes onto the inhibitor delivered two PARK7 probes. The Rhodamine110 probe provides a high-throughput screening compatible FP assay, showcased by screening a compound library (8000 molecules). The SulfoCy5-equipped probe is a valuable tool to assess the effect of PARK7 inhibitors in a cell lysate. Our work creates new possibilities to explore PARK7 function in a physiologically relevant setting and develop new and improved PARK7 inhibitors.
Zero phase difference capacitance control (ZPDCC) for magnetically resonant wireless power transmission (2013)

In a magnetically resonant wireless power transmission system, a DC-DC power transmission efficiency (η <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TOTAL</sub> ) at an inherent resonant frequency (f <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">RES</sub> ) is degraded when the distance between a transmitter (TX) coil and a receiver (RX) coil is short, because the frequency dependence of η <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TOTAL</sub> has two peaks. In order to solve the efficiency degradation, a zero phase difference capacitance control (ZPDCC) is proposed, which is suitable for the integration to LSI's. In ZPDCC, either of the two peaks is shifted to fRES and η <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TOTAL</sub> is increased by tuning the capacitance (C) of the resonator in TX and RX to keep the zero phase difference (θ = 0) between the voltage and the current in TX at Δθ / ΔC > 0. Both TX and RX circuits are fabricated in a 3.3V, 180nm CMOS. By introducing ZPDCC, the measured η <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">TOTAL</sub> at fRES of 13.56MHz increases 1.7 times from 16% to 27% at the distance of 2.5mm between the TX and RX coils with a diameter of 40mm.
Access and Use of the GUDMAP Database of Genitourinary Development (2012)

The Genitourinary Development Molecular Atlas Project (GUDMAP) aims to document gene expression across time and space in the developing urogenital system of the mouse, and to provide access to a variety of relevant practical and educational resources. Data come from microarray gene expression profiling (from laser-dissected and FACS-sorted samples) and in situ hybridization at both low (whole-mount) and high (section) resolutions. Data are annotated to a published, high-resolution anatomical ontology and can be accessed using a variety of search interfaces. Here, we explain how to run typical queries on the database, by gene or anatomical location, how to view data, how to perform complex queries, and how to submit data.
Clustering the autisms using glutamate synapse protein interaction networks from cortical and hippocampal tissue of seven mouse models (2018)

These data highlight the great heterogeneity among models, but suggest that high-dimensional measures of a synaptic protein network may allow differentiation of subtypes of ASD with shared molecular pathology.
Chalupa, Jiří / Reichwalderová, Eva (2021): Danza de máscaras. Motivaciones políticas e ideológicas de las transformaciones de las imágenes mediáticas. Picasso, García Lorca y Ortega y Gasset en la prensa checoslovaca. Barcelona. Caligrama Editorial (2022)

Chalupa,
THE ASSOCIATION BETWEEN SYSTOLIC BLOOD PRESSURE AND HEART RATE IN EMERGENCY DEPARTMENT PATIENTS: A MULTICENTER COHORT STUDY (2023)

No association between SBP and HR existed in ED patients of any age category, nor in ED patients who were hospitalized with a suspected infection, even during and after ED treatment. Emergency physicians may be misled by traditional concepts about HR disturbances because tachycardia may be absent in hypotension.
Compatibility of Dimethyl Ether (DME) and Diesel Blends with Fuel System Polymers: A Hansen Solubility Analysis Approach (2016)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;The compatibility of notable infrastructure elastomers and plastics with DME and its blends with diesel fuel were examined using solubility analysis. The elastomer materials were fluorocarbon, acrylonitrile butadiene rubber (NBR), styrene butadiene (SBR), neoprene, polyurethane and silicone. Plastic materials included polyphenylene sulfide (PPS), polyethylene terephthalate (PET), polytetrafluoroethylene (PTFE), polyvinylidene fluoride (PVDF), polyoxymethylene (POM), polybutylene terephthalate (PBT), polypropylene (PP), high density polyethylene (HDPE), along with several nylon grades and thermosetting resins. These materials have been rigorously studied with other fuel types, and their volume change results were found to correspond well with their predicted solubility levels.&lt;/div&gt;&lt;div class="htmlview paragraph"&gt;A Hansen solubility analysis was performed for each material with DME, diesel, and blends of both fuel components. The results for the elastomers indicate that DME and its blends with diesel fuel will offer improved compatibility with NBR and SBR materials. Silicone, neoprene and polyurethane show similar solubility potential for any combination of DME and diesel, so no degradation is expected with DME. In contrast, fluorocarbon can be expected to become increasingly incompatible with increased DME concentration. In general, the solubility analysis also indicated that many of the plastic materials can be expected to have good to excellent compatibility with DME and its blends with diesel fuel. The analysis also indicated that polyester resins should exhibit high solubility (and therefore high swelling) in both diesel and DME. However, previous empirical results showed that this result was not an accurate reflection of polyester resin performance in diesel fuel.&lt;/div&gt;&lt;/div&gt;
Biological monitoring and the influence of genetic polymorphism of As3MT and GSTs on distribution of urinary arsenic species in occupational exposure workers (2014)

The findings of the study point out that the concentration of iAs or the sum of iAs + MMA in urine can be a reliable biological indicator of occupational exposure to arsenic. This study demonstrates that As3MT and/or GSTs genotype may influence As metabolism. Nevertheless, further studies investigating genetic polymorphism in occupational conditions are required.
A compact VEGF signature associated with distant metastases and poor outcomes (2019)

Abstract: Background: Tumor metastases pose the greatest threat to a patient's survival, and thus, understanding the biology of disseminated cancer cells is critical for developing effective therapies. Methods: Microarrays and immunohistochemistry were used to analyze primary breast tumors, regional (lymph node) metastases, and distant metastases in order to identify biological features associated with distant metastases. Results: When compared with each other, primary tumors and regional metastases showed statistically indistinguishable gene expression patterns. Supervised analyses comparing patients with distant metastases versus primary tumors or regional metastases showed that the distant metastases were distinct and distinguished by the lack of expression of fibroblast/mesenchymal genes, and by the high expression of a 13-gene profile (that is, the 'vascular endothelial growth factor (VEGF) profile') that included VEGF, ANGPTL4, ADM and the monocarboxylic acid transporter SLC16A3. At least 8 out of 13 of these genes contained HIF1α binding sites, many are known to be HIF1α-regulated, and expression of the VEGF profile correlated with HIF1α IHC positivity. The VEGF profile also showed prognostic significance on tests of sets of patients with breast and lung cancer and glioblastomas, and was an independent predictor of outcomes in primary breast cancers when tested in models that contained other prognostic gene expression profiles and clinical variables. Conclusion: These data identify a compact in vivo hypoxia signature that tends to be present in distant metastasis samples, and which portends a poor outcome in multiple tumor types. This signature suggests that the response to hypoxia includes the ability to promote new blood and lymphatic vessel formation, and that the dual targeting of multiple cell types and pathways will be needed to prevent metastatic spread.
Efficacy of Novel Collagen/Gelatin Scaffold With Sustained Release of Basic Fibroblast Growth Factor for Dermis-like Tissue Regeneration (2011)

We have developed collagen/gelatin sponges (CGS) with a gelatin concentration of 10 wt% to sustain the release of basic fibroblast growth factor (bFGF). The objective of this study is to elucidate the efficacy of CGS impregnated with different concentrations of bFGF, using mouse skin defects. CGSs impregnated with normal saline solution (NSS) or bFGF solution (1, 7, 14, or 50 μg/cm) were implanted into full-thickness skin defects on the backs of mice. The wound area, neoepithelium length, and total area of newly formed capillaries in CGS were evaluated. The group of CGS with 7-μg/cm bFGF was significantly superior to the NSS group in all evaluated items. CGS impregnated with the appropriate dosage of bFGF accelerates dermis-like tissue formation 2 or 3 times earlier than existing artificial dermis. The combination of CGS and bFGF could solve the problem of the existing artificial dermis and be very promising for the treatment of skin defects.
Optical Spectra of Low Flux Radio Sources (1989)

Low flux radio sources are important for a variety of reasons. In principle, a 1 mJy survey that is over 1000 times fainter than the 3CR allows us to reach objects 20 times more distant, almost literally to the edge of the universe, or to detect much less luminous sources at the same distances. We can hope to detect primeval galaxies, to check the idea that objects with redshifts z greater than 3 or 4 are optically hidden by dust, to detect new populations of radio objects, to possess pointers to distant clusters and galaxies, as well as to understand better the AGN phenomenon.
Diffusion Barriers Minimizing the Strength Degradation of Reactive Air Brazed Ba0.5Sr0.5Co0.8Fe0.2O3-δ Membranes during Aging (2023)

The separation of oxygen from air by means of inorganic ceramic membranes requires gas-tight ceramic-metal joints that enable reliable permeation operation in the oxygen partial pressure gradient at 850 °C. Reactive air brazing is a promising method to solve this challenge. However, reactive air brazed BSCF membranes suffer from a significant strength degradation that is caused by unhindered diffusion from the metal component during aging. In this study, we investigated how diffusion layers applied on the austenitic steel AISI 314 influence the bending strength of BSCF-Ag3CuO-AISI314 joints after aging. Three different approaches were compared as diffusion barriers: (1) aluminizing via pack cementation, (2) spray coating with NiCoCrAlReY, and (3) spray coating with NiCoCrAlReY and an additional 7YSZ top layer. Coated steel components were brazed to bending bars and aged for 1000 h at 850 °C in air prior to four-point bending and subsequent macroscopic as well microscopic analyses. In particular, coating with NiCoCrAlReY showed low-defect microstructures. The characteristic joint strength was raised from 17 MPa to 35 MPa after 1000 h aging at 850 °C. In addition, the dominant delamination fracture between the steel and the mixed oxide layer, observed in the reference series with uncoated steel, could be replaced by mixed and ceramic fractures of higher strength. The effect of residual joint stresses on the crack formation and path is analyzed and discussed. Chromium poisoning could no longer be detected in the BSCF, and interdiffusion through the braze was effectively reduced. Since the strength degradation of reactive air brazed joints is mainly caused by the metallic joining partner, the findings on the effect of the diffusion barriers in BSCF joints might be transferred to numerous other joining systems.