gebhart/patrepeval huggingface dataset:
The use of the radioimmunoprecipitation-PEG assay (RIPEGA) to detect anti-IgG antibodies. (1977)

&lt;p&gt;In this work we study pedestrian-pedestrian interactions from observational experimental data in diluted pedestrian crowds. While in motion, pedestrians continuously adapt their walking paths trying to preserve mutual comfort distances and to avoid collisions. Leveraging on a high-quality, high-statistics data set, composed of several few millions real-life trajectories acquired from state-of-the-art observational experiments (about 6 months of high-resolution pedestrian tracks acquired in a train station), we develop a quantitative model capable of addressing interactions in the case of binary collision avoidance. We model interactions in terms of both long-range (sight based) and short-range (hard-contact avoidance) forces, which we superimpose on our Langevin model for noninteracting pedestrian motion [Corbetta, Phys. Rev. E 95, 032316 (2017)2470-004510.1103/PhysRevE.95.032316] (here further tested and extended). The model that we propose here features a Langevin dynamics with fast random velocity fluctuations that are superimposed on the slow dynamics of a hidden model variable: the intended walking path. In the case of interactions, social forces may act both on the intended path and on the actual walked path. The model is capable of reproducing quantitatively relevant statistics of the collision avoidance motion, such as the statistics of the side displacement and of the passing speed. Rare occurrences of actual bumping events are also recovered. Furthermore, comparing with large data sets of real-life tracks involves an additional computational challenge so far neglected: identifying automatically, within a database containing very heterogeneous conditions, only the relevant events corresponding to binary avoidance interactions. In order to tackle this challenge, we propose a general approach based on a graph representation of pedestrian trajectories, which allows us to effectively operate complexity reduction for efficient data classification and selection.&lt;/p&gt;
HOLE-BLOCKING LAYERS FOR SILICON/ORGANIC HETEROJUNCTIONS: A NEW CLASS OF HIGH-EFFICIENCY LOW-COST PV (2017)

This project is the first investigation of the use of thin titanium dioxide layers on silicon as a hole-blocking / electron-transparent selective contact to silicon. The work was motivated by the goal of a high-efficiency low-cost silicon-based solar cells that could be processed entirely at low temperature (300 Degree Celsius) or less, without requiring plasma-processing.
Hematopoietic niche and bone meet (2008)

The HSC niche comprises complex interactions between multiple cell types and molecules requiring cell-cell signaling as well as local secretion. These components can be thought of as therapeutic targets not only for HSC expansion, but also to modify behavior of hematopoietic malignancies and cancer metastases to the bone.
Improved behavioral outcomes after progesterone administration in aged male rats with traumatic brain injury (2011)

Twenty-month-old male Fischer 344 rats with bilateral contusions of the frontal cortex (n=8/group) or sham operations received 16 mg/kg of progesterone or vehicle at 1 and 6 h post-injury, then once every 24 h for the next seven days, with tapering of the dose over the final two treatments. The rats' behavioral recovery was then evaluated on tests of locomotor activity and Morris water maze learning. All rats were sacrificed 21 days post-TBI and brains were perfused and cryoprotected for necrotic cavity measurements. The injury produced significant impairments in activity and spatial learning compared to sham controls. The progesterone-treated rats had better functional outcomes than vehicle-treated rats with similar cortical injuries. The neurosteroid treatment did not affect the size of the necrotic cavity.
Polymer Conductivity through Particle Connectivity (2009)

Conducting polymers, especially those template-synthesized on polymer acids, have attracted considerable attention for applications in organic and polymer electronics because of their processability and patternability, excellent mechanical properties, and robust electronic properties. The template synthesis of conductive polymers with polymer acids in aqueous media results in electrostatically stabilized submicrometer particles. With a model system of polyaniline that is template-synthesized in a presence of poly(2-acrylamido-2-methyl-1-propanesulfonic acid), or PAAMPSA, we show that the molecular characteristics of PAAMPSA influence the size and size distribution of the particles. We further demonstrate that it is the packing of these particles that governs macroscopic conduction in the solid state. Accordingly, the macroscopic conductivity of such polymers scales linearly with particle density.
Cutoff for Mixing Times on Random Abelian Cayley Graphs (2018)

Consider the random Cayley graph of a finite, Abelian group $G = \oplus_{j=1}^d \mathbb{Z}_{m_j}$ with respect to $k$ generators chosen uniformly at random. We prove that the simple random walk on this graph exhibits abrupt convergence to equilibrium, known as cutoff, subject to $k \gg 1$, $\log k \ll \log |G|$ and mild conditions on $d$ and $\min_j m_j$ in terms of $|G|$ and $k$. 
In accordance with spirit of a conjecture of Aldous and Diaconis, the cutoff time is shown to be independent of the algebraic structure of the group; it occurs around the time that the entropy of the simple random walk on $\mathbb{Z}^k$ is $\log|G|$, independent of $d$ and $\{m_j\}_{j=1}^d$. Moreover, we prove a Gaussian profile of convergence to equilibrium inside the cutoff window. 
We also prove that the order of the spectral gap is $|G|^{-2/k}$ with high probability (as $|G|$ and $k$ diverge); this extends a celebrated result of Alon and Roichman.
Origins of Initiation Rate Differences in Ruthenium Olefin Metathesis Catalysts Containing Chelating Benzylidenes (2015)

A series of second-generation ruthenium olefin metathesis catalysts was investigated using a combination of reaction kinetics, X-ray crystallography, NMR spectroscopy, and DFT calculations in order to determine the relationship between the structure of the chelating o-alkoxybenzylidene and the observed initiation rate. Included in this series were previously reported catalysts containing a variety of benzylidene modifications as well as four new catalysts containing cyclopropoxy, neopentyloxy, 1-adamantyloxy, and 2-adamantyloxy groups. The initiation rates of this series of catalysts were determined using a UV/vis assay. All four new catalysts were observed to be faster-initiating than the corresponding isopropoxy control, and the 2-adamantyloxy catalyst was found to be among the fastest-initiating Hoveyda-type catalysts reported to date. Analysis of the X-ray crystal structures and computed energy-minimized structures of these catalysts revealed no correlation between the Ru–O bond length and Ru–O bond strength. On the other hand, the initiation rate was found to correlate strongly with the computed Ru–O bond strength. This latter finding enables both the rationalization and prediction of catalyst initiation through the calculation of a single thermodynamic parameter in which no assumptions about the mechanism of the initiation step are made.
Eccentric Resistance Training Ameliorates Muscle Weakness in a Mouse Model of Idiopathic Inflammatory Myopathies (2020)

ECC training protected against the reduction in myofibrillar force-generating capacity in an IIM mouse model, and this occurred via inhibition of ER stress responses and small HSP-mediated myofibrillar stabilization.
The Evaluation of Temporary Degradation in Quarter Micron MOSFET by Hydrogen Passivation of Boron (1996)

This paper evaluates the outermost case of temporary MOSFET's characteristics degradation by hydrogen passivation of B (Boron) in low temperature process. A 1 μm p-MOSFET showed slight increase of drain resistance and about 40 3 reduction of sheet resistance, experimentally. The simulation of 0.25 μm MOSFET's shows the channel length increase of more than 20 3, drain resistance increase about 40 3, as the results of 90 3 passivation of dopant in lightly doped source and drain (LDD). To reduce the hydrogen passivation effects, the shortest LDD structure or heavily doped drain are required, and lower substrate impurity concentration must be chosen as far as possible to suppress the variation of threshold voltage. For the deep-submicron channel devices, however, it's difficult to make the sufficiently low resistive contact resistance.
Case Scenario (2013)

Nathan, Aruna T.*; Antzelevitch, Charles†; Montenegro, Lisa M.*; Vetter, Victoria L.‡ Author Information
Nitric Oxide–Dependent Endothelial Dysfunction and Reduced Arginine Bioavailability in Plasmodium vivax Malaria but No Greater Increase in Intravascular Hemolysis in Severe Disease (2016)

Endothelial function is impaired in nonsevere and severe vivax malaria, is associated with reduced L-arginine bioavailability, and may contribute to microvascular pathogenesis. Severe disease appears to be more associated with extravascular hemolysis than with intravascular hemolysis.
Giant Extra-Articular Synovial Chondromatosis of the Ankle Joint - A Rare Case Report. (2020)

Extra-articular involvement in SC has been mainly reported in the synovial sheath or bursae of the hand and foot, but they can involve ankle joint also. In recent times, there have been concerns about potential malignant transformation of these lesion to chondrosarcoma, diagnosing these lesions have become important.
Decision tree clustering for KL-HMM (2012)

Recent Automatic Speech Recognition (ASR) studies have shown that Kullback-Leibler diverge based hidden Markov models (KL-HMMs) are very powerful when only small amounts of training data are available.However, since the KL-HMMs use a cost function that is based on the Kullback-Leibler divergence (instead of maximum likelihood), standard ASR algorithms such as the commonly used decision tree clustering are not applicable in general.In this communication, we present an algorithm that allows us to perform decision tree clustering for KL-HMM based ASR systems.
A proposed algaculture facility at L Lake (1988)

The proposed project involves the development and establishment of an aquaculture system in L Lake, a 1000-acre cooling lake constructed at the Savannah River Plant (SRP) in 1985. Waste heat and excess nutrients would be used to produce valuable products derived from microalgae biomass. The process would simultaneously serve as an innovative mitigation scheme to help overcome the potential environmental problems associated with using L Lake to dissipate heat from the secondary cooling system for L Reactor. The project involves using the upper 300 acres of L Lake, the region most affected by thermal effluents, to cultivate (produce and harvest) microalgae, a process known commercially as ''algaculture''. Selected strains of nontoxic, thermotolerant, filamentous, nitrogen-fixing, blue-green algae would be used. These algae could be inoculated into the uppermost sections of L Lake, near the reactor outfall, and harvested at the lower boundary of the 300-acre project area with microstrainers. Part of the harvested biomass could be recycled back to the reactor outfall region to maintain a high density of the desired algal strain(s) within the project area.
From Cis-Regulatory Elements to Complex RNPs and Back (2012)

Messenger RNAs (mRNAs), the templates for translation, have evolved to harbor abundant cis-acting sequences that affect their posttranscriptional fates. These elements are frequently located in the untranslated regions and serve as binding sites for trans-acting factors, RNA-binding proteins, and/or small non-coding RNAs. This article provides a systematic synopsis of cis-acting elements, trans-acting factors, and the mechanisms by which they affect translation. It also highlights recent technical advances that have ushered in the era of transcriptome-wide studies of the ribonucleoprotein complexes formed by mRNAs and their trans-acting factors.
Abstract 3870: Telomeric non-coding RNA causes genome-wide alteration of gene expression in cancer (2015)

Abstract The end replication problem of linear chromosome DNA causes telomere shortening and eventual senescence of normal cells. Cancer cells reactivate telomerase to maintain their telomere length and exhibit an infinite replicative potential. However, telomerase activation does not necessarily increase the average telomere length in cancer cells. Actually, cancer cells often maintain shorter telomeres than the cells in the surrounding normal tissues. We previously demonstrated that forced telomere elongation in cancer cells promotes their differentiation in a xenograft tumor and represses innate immune genes that are upregulated in various human cancers. This implies that short telomeres of cancer cells contribute to their malignancy. However, it is completely unknown how such genetic repression is caused by elongated telomeres. Here, we report that telomeric repeat-containing RNA (TERRA) induces a genome-wide alteration of gene expression in telomere-elongated human cancer cells. Using three different cancer cell lines, including those from prostate, breast and stomach, we found that telomere elongation by hTERT overexpression up-regulates TERRA signals, which were detected by northern blot analysis, and down-regulates innate immune genes such as STAT1, ISG15, and OAS3 in vivo. These changes were caused by telomere elongation and not by enhanced telomerase activity or hTERT overexpression per se. Down-regulation of the innate immune genes was also observed in the telomere-elongated cells under three-dimensional (3D) culture conditions, which mimicked the tumor microenvironment in vivo. Introduction of TERRA oligonucleotides repressed the innate immune genes even in cells with short telomeres under 3D culture conditions. Intriguingly, this gene repression appeared to occur from the action of the non-canonical nucleic acid structure called G-quadruplex (G4) in TERRA, because non-telomeric (i.e., non-G4-forming) control oligonucleotides had no effect whereas another non-telomeric but G4-forming oligonucleotide phenocopied the TERRA oligonucleotides. Transcriptome analysis revealed that telomere elongation and G4-forming oligonucleotides showed similar gene expression signatures. Most of the commonly suppressed genes were involved in the innate immune system and were up-regulated in various human cancers. Taken together, these observations suggest that the telomeric non-coding RNA G4 counteracts cancer malignancy through suppression of innate immune genes, and give a new insight into our understanding of telomere shortening in human cancer. Citation Format: Kyotaro Hirashima, Hiroyuki Seimiya. Telomeric non-coding RNA causes genome-wide alteration of gene expression in cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 3870. doi:10.1158/1538-7445.AM2015-3870
Current-mode differential logic circuits for low power digital systems (2002)

A current-mode differential logic scheme is introduced. By biasing in the subthreshold regime, the transistors are operated with maximum normalized transconductance, g/sub m//I. The rapid saturation of devices operated in subthreshold allows for radical scaling of supply voltages to only 300 mV. Application of a back-bias further increases the g/sub m//I of the transistors, and hence the gain of the gates. The back bias also assists in the reduction of stray junction and gate-bulk capacitance. Operating with small voltage swings, delays of a few hundred nanoseconds can be achieved with bias currents of 50 nA. This results in operational speeds of a few megahertz at greatly reduced power consumption compared to standard CMOS digital logic. Experimental results are presented and extrapolated to a scaled version of the circuit.
Successful treatment for bronchial bleeding from invasive pulmonary metastasis of hepatocellular carcinoma: a case report. (2002)

Pulmonary metastasis is frequently seen in patients with advanced hepatocellular carcinoma. However, information is limited concerning life-threatening complications and effective treatment of pulmonary metastasis because of the poor prognosis of patients with advanced hepatocellular carcinoma. Recent remarkable progress in detection and treatment of hepatocellular carcinoma has improved prognosis, making management of pulmonary metastasis an important clinical issue. We describe a 68-year-old man with pulmonary metastasis of hepatocellular carcinoma and sudden onset of hemoptysis from bronchial invasion. Transcatheter embolization was performed successfully via the bronchial artery with disappearance of bloody sputum. Peribronchial pulmonary metastasis of hepatocellular carcinoma can cause life-threatening hemoptysis. Transcatheter arterial embolization may be one of therapeutics for hemoptysis from invasive pulmonary metastasis of hepatocellular carcinoma.
Systemic Treatment for Advanced and Metastatic Malignant Peripheral Nerve Sheath Tumors—A Sarcoma Reference Center Experience (2020)

Malignant peripheral nerve sheath tumor (MPNST) is a rare type of soft tissue sarcomas. The localized disease is usually treated with surgery along with perioperative chemo- or radiotherapy. However, up to 70% of patients can develop distant metastases. The study aimed to evaluate the modes and outcomes of systemic treatment of patients with diagnosed MPNST treated in a reference center. In total, 115 patients (56 female and 59 male) diagnosed with MPNST and treated due to unresectable or metastatic disease during 2000-2019 were included in the retrospective analysis. Schemes of systemic therapy and the outcomes-progression-free survival (PFS) and overall survival (OS)-were evaluated. The median PFS in the first line was 3.9 months (95% CI 2.5-5.4). Doxorubicin-based regimens were the most commonly used in the first line (50.4% of patients). There were no significant differences in PFS between chemotherapy regimens most commonly used in the first line (<i>p</i> = 0.111). The median OS was 15.0 months (95% CI 11.0-19.0) and the one-year OS rate was 63%. MPNST are resistant to the majority of systemic therapies, resulting in poor survival in advanced settings. Chemotherapy with doxorubicin and ifosfamide is associated with the best response and longest PFS. Future studies and the development of novel treatment options are necessary for the improvement of treatment outcomes.
Microscopic Simulation and Life Prediction of High Cr Steel Welds Subject to Type IV Creep Damage (2013)

The micro-macro combined creep damage simulation based on the grain-boundary-fracture-resistance model was applied to the evaluation of small defects distribution in fine-grained heat-affected zones of longitudinal welds in the actual size elbow of modified 9Cr-1Mo (9Cr-1MoVNb) steel subject to internal pressure at 923K. On the basis of simulation results, a prediction scheme for final rupture life of welds was discussed using the damage mechanics concept and effective stress. The applicability of nonlinear fracture mechanics was also discussed assuming the crack length from the microscopic simulation results. Obtained results are summarized as follows : As results of the simulation showed, peaks of the number density of small defects in the subsurface could be predicted, showing good correspondence with the observed results. Final failure life prediction based on the damage mechanics concept was found to be applicable, by assuming both the final failure surface connecting the weakest grain boundaries, and effective stress against this surface. Fracture mechanics approach was also found to be applicable when assuming the crack length from the high peaks of the simulated small defect in the last stage of creep life.
Modeling the optical properties of twisted bilayer photonic crystals (2021)

We demonstrate a photonic analog of twisted bilayer graphene that has ultra-flat photonic bands and exhibits extreme slow-light behavior. Our twisted bilayer photonic device, which has an operating wavelength in the C-band of the telecom window, uses two crystalline silicon photonic crystal slabs separated by a methyl methacrylate tunneling layer. We numerically determine the magic angle using a finite-element method and the corresponding photonic band structure, which exhibits a flat band over the entire Brillouin zone. This flat band causes the group velocity to approach zero and introduces light localization, which enhances the electromagnetic field at the expense of bandwidth. Using our original plane-wave continuum model, we find that the photonic system has a larger band asymmetry. The band structure can easily be engineered by adjusting the device geometry, giving significant freedom in the design of devices. Our work provides a fundamental understanding of the photonic properties of twisted bilayer photonic crystals and opens the door to the nanoscale-based enhancement of nonlinear effects.
Comparison of Streptokinase with Heparin: Late Results in the Treatment of Deep Venous Thrombosis (1979)

Nineteen cases were reinvestigated 8-14 years after treatment with SK or heparin. Judging from personal interviews, foot volumometry and phlebography, treatment with SK appears to be more preferable since it was less often followed by late severe postthrombotic changes.
Corrections to “Optical Characterization of Chalcogenide Ge–Sb–Se Waveguides at Telecom Wavelengths” (2017)

The original letter [1] contains an error in the two-photon absorption coefficient of the chalcogenide waveguides. The fitting equation (1) used in [1] was incorrect, leading to an overestimation of the two-photon absorption.
Mechanisms of Resetting Reentrant Circuits in Canine Ventricular Tachycardia (2001)

Multiple mechanisms revealed by mapping cause resetting of reentrant circuits.
Anforderungen an die ökonomischen Paradigmen Lateinamerikas (2019)

Eine vielseitige Perspektive zum ambivalenten Begriff des Fortschritts: global, historisch, politisch, ökonomisch, ökologisch und religiös.
Palladium/phosphinated polystyrene as a catalyst in the Heck arylation. A comparative study (1985)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTPalladium/phosphinated polystyrene as a catalyst in the Heck arylation. A comparative studyCarl Magnus Andersson, Kostas Karabelas, Anders Hallberg, and Carlaxel AnderssonCite this: J. Org. Chem. 1985, 50, 20, 3891–3895Publication Date (Print):October 1, 1985Publication History Published online1 May 2002Published inissue 1 October 1985https://pubs.acs.org/doi/10.1021/jo00220a041https://doi.org/10.1021/jo00220a041research-articleACS PublicationsRequest reuse permissionsArticle Views727Altmetric-Citations102LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts