gebhart/patrepeval huggingface dataset:
Ketotifen abrogates local and systemic consequences of rat intestinal ischemia–reperfusion injury (2005)

This is the first study to demonstrate that ketotifen is a powerful inhibitor of I/R-induced leukocyte adhesion and can prevent localized and reduce remote organ damage after intestinal I/R injury. However, its effects are manifested in the absence of any influence on intestinal I/R-induced vascular leakage.
Proximity-dependent biotin labelling in yeast using the engineered ascorbate peroxidase APEX2 (2016)

The engineered ascorbate peroxidase (APEX2) has been effectively employed in mammalian cells to identify protein-protein interactions. APEX2 fused to a protein of interest covalently tags nearby proteins with biotin-phenol (BP) when H2O2 is added to the cell culture medium. Subsequent affinity purification of biotinylated proteins allows for identification by MS. BP labelling occurs in 1 min, providing temporal control of labelling. The APEX2 tool enables proteomic mapping of subcellular compartments as well as identification of dynamic protein complexes, and has emerged as a new methodology for proteomic analysis. Despite these advantages, a related APEX2 approach has not been developed for yeast. Here we report methods to enable APEX2-mediated biotin labelling in yeast. Our work demonstrated that high osmolarity and disruption of cell wall integrity permits live-cell biotin labelling in Schizosaccharomyces pombe and Saccharomyces cerevisiae respectively. Under these conditions, APEX2 permitted targeted and proximity-dependent labelling of proteins. The methods described herein set the stage for large-scale proteomic studies in yeast. With modifications, the method is also expected to be effective in other organisms with cell walls, such as bacteria and plants.
Oxazole and Thiazole Analogs of Sulindac for Cancer Prevention (2018)

In general, replacement of the amide function of SSA analogs had a negative impact on the cell lines tested. A small number of hits incorporating rigid oxazole or thiazole groups in the sulindac scaffold in place of the amide linkage show comparable activity to our lead agent SSA.
A Review of Selective Salpingography and Fallopian Tube Catheterization (2000)

Use of selective salpingography and fallopian tube recanalization has revolutionized the diagnosis and treatment of infertility. Selective salpingography, a diagnostic procedure in which the fallopian tube is directly opacified through a catheter placed in the tubal ostium, has been used since the late 1980s to differentiate spasm from true obstruction and to clarify discrepant findings from other tests. In fallopian tube recanalization, a catheter and guide wire system is used to clear proximal tubal obstructions. The recanalization procedure is simple for interventional radiologists to perform and is successfully completed in most patients (71%-92%). Pregnancy rates after the procedure have been variable, with an average rate of 30%. The combination of selective salpingography with fallopian tube recanalization has improved the overall management of infertility caused by tubal obstruction. The same catheterization technique used in fallopian tube recanalization is currently being explored for use in tubal sterilization.
Confocal theta fluorescence microscopy with annular apertures (1996)

In a confocal theta fluorescence microscope, two objective lenses with circular apertures are used, one to illuminate the sample and the other to detect the emitted light at an angle to the illumination axis. We show that annular illumination and detection apertures lead to a reduction in the extent of the point-spread function. A spatial resolution improved by more than 50% can be achieved with a central obstruction blocking the inner 80% of the diameter. For the limit of a very narrow annular aperture and a numerical aperture of 0.75, the volume at half-maximum of the point-spread function is reduced from 15to5 aL. Amixed setup with anannular illumination aperture and a circular detection aperture is also considered.
Autologous Hematopoietic Stem Cell Transplantation in Crohn's disease: result from our 14 first patients (2015)

status: Accepted
Comprehensive study of Al-induced layer-exchange growth for orientation-controlled Si crystals on SiO2 substrates (2014)

Orientation-controlled crystalline Si films on insulating substrates are strongly required to achieve high-performance thin-film devices for next-generation electronics. We have comprehensively investigated the layer-exchange kinetics of Al-induced crystallization (AIC) in stacked structures, i.e., amorphous-Si/Al-oxide/Al/SiO2-substrates, as a function of the air-exposure time of Al surfaces (tair: 0–24 h) to form Al-oxide interface-layers, the thickness of Al and Si layers (dAl, dSi: 50–200 nm), the annealing temperature (450–500 °C), and the annealing time (0–50 h). It has been clarified that longer tair (&amp;gt;60 min) and/or thinner dAl and dSi (&amp;lt;50 nm) lead to the (111) oriented growth; in contrast, shorter tair (&amp;lt;60 min) and/or thicker dAl and dSi (&amp;gt;100 nm) lead to the (100) oriented growth. No correlation between the annealing temperature and the crystal orientation is observed. Detailed analysis reveals that the layer-exchange kinetics are dominated by “supply-limited” processing, i.e., diffusion of Si atoms into Al layers through Al-oxide layer. Based on the growth rate dependent Si concentration profiles in Al layers, and the free-energy of Si at Al-oxide/Al or Al/SiO2 interfaces, a comprehensive model for layer-exchange growth is proposed. This well explains the experimental results of not only Si-AIC but also another material system such as gold-induced crystallization of Ge. In this way, a growth technique achieving the orientation-controlled Si crystals on insulating substrates is established from both technological and scientific points of view.
Increased heat dissipation with the X-divertor geometry facilitating detachment onset at lower density in DIII-D (2017)

The X-Divertor geometry on DIII-D has demonstrated reduced particle and heat fluxes to the target, facilitating detachment onset at ~20% lower upstream density and higher H-mode pedestal pressure than a standard divertor. SOLPS modeling suggests that this effect cannot be explained by an increase in total connection length alone, but rather by the addition of connection length specifically in the power-dissipating volume near the target, via poloidal flux expansion and flaring. But, poloidal flaring must work synergistically with divertor closure to most effectively reduce the detachment density threshold. Furthermore, the model also points to carbon radiation as the primary driver of power dissipation in divertors on the DIII-D floor, which is consistent with experimental observations. Sustainable divertor detachment at lower density has beneficial consequences for energy confinement and current drive efficiency in the core for advanced tokamak (AT) operation, while simultaneously satisfying the exhaust requirements of the plasma-facing components.
Plasma-assisted laser deposition of YBa2Cu3O7−δ (1991)

The change in superconducting properties due to the presence of a bias electrode in in situ laser deposition was explored. It was found that the bias ring allowed a 50–70 °C reduction in the deposition temperature. This reduction is correlated to an increase in ion current impinging on the substrate.
Implementing the United Nations Sustainable Development Goals for the Systems Engineering of Multinational Corporations (2018)

Abstract The United Nations Sustainable Development Goals (SDGs) were adopted in 2015 by 193 countries. They can be characterised as sustainability ‘requirements’ for the global system. This paper provides a vision of how Multinational Companies (MNCs) are likely to experience the SDGs and their implications for Systems Engineering (SE) of the Enterprise. The SDGs do not have the status of international law and may be implemented differently in different countries over the period to 2030. MNCs will face choices about how they wish to comply today in anticipation of future requirements. Thereby, they also have the opportunity to avoid systems sustainability failures later on. This paper presents an initial approach to implementing the SDGs in the form of business requirements. The research will pave the ground for the development of a systematic framework for the adoption, monitoring and assessment of the SDGs in an SE context.
Acquired Dependence of Acute Myeloid Leukemia on the DEAD-Box RNA Helicase DDX5 (2014)

Acute myeloid leukemia (AML) therapy involves compounds that are cytotoxic to both normal and cancer cells, and relapsed AML is resistant to subsequent chemotherapy. Thus, agents are needed that selectively kill AML cells with minimal toxicity. Here, we report that AML is dependent on DDX5 and that inhibiting DDX5 expression slows AML cell proliferation in vitro and AML progression in vivo but is not toxic to cells from normal bone marrow. Inhibition of DDX5 expression in AML cells induces apoptosis via induction of reactive oxygen species (ROS). This apoptotic response can be blocked either by BCL2 overexpression or treatment with the ROS scavenger N-acetyl-L-cysteine. Combining DDX5 knockdown with a BCL2 family inhibitor cooperates to induce cell death in AML cells. By inhibiting DDX5 expression in vivo, we show that DDX5 is dispensable for normal hematopoiesis and tissue homeostasis. These results validate DDX5 as a potential target for blocking AML.
pNTQS: Easily Accessible High-Capacity Redox-Active Polymer for Organic Battery Electrodes (2018)

Despite a continuous effort to develop novel materials for organic polymer-based batteries, their commercial success is still hampered by the demanding synthesis and the high costs of these materials. To overcome these issues, we developed poly(naphthotriazolequinonestyrene) (pNTQS), the first redox-active polymer bearing naphthotriazolediones, and have demonstrated its promising characteristics for an application in organic batteries. The polymer is effectively synthesized using a straightforward cycloaddition reaction followed by a free-radical polymerization. The electrochemical investigations of this new material reveal a two-electron storage capability, and an electrolyte system optimized for use in Li–organic batteries was established. Coin cells comprising pNTQS as active electrode material reveal an excellent capacity of 135 mAh g–1, which exceeds most of the commonly applied polymer-based materials, while a capacity loss of only 30% over 1000 cycles was observed.
Advanced Manufacturing of Patient‐Specific Occluders for the Left Atrial Appendage with Minimally Invasive Delivery (2020)

A novel method for the rapid prototyping of personalized inflatable left atrial appendage occluders, suitable for minimally invasive delivery, is demonstrated. The method allows for the design, fabrication, and quantitative testing of implants based on an individual's computed tomography (CT) scan. The performance of a left atrial appendage occluder by characterizing its ability to anchor, prevent leaks, and not obstruct the left atrium is reported on. The design of the occluder by varying features such as size, inflation fluids, and surface patterns is optimized. The implant, and its delivery via a minimally invasive catheter, is demonstrated in a 3D‐printed left atrial model. Herein, the way for leveraging advanced manufacturing and imaging technologies for the development of personalized intracardiac implants for transcatheter delivery is described.
The Self-Assembly of a [2]Catenane (1991)

The template-directed synthesis of a [2]catenane, in which the interlocking rings are bisparaphenylene-34-crown-10 (BPP34C10) and a cyclobis (paraquat-p-phenylene) tetracationic macrocycle, is reported to occur when 4,4′ -bipyridine and 1,4-bis(bromomethyl)benzene are added to a solution of BPP34C10 in dimethylformamide. This remarkable act of self-assembly, which requires the coming together of five molecular components, is rationalised in terms of the mutual recognition properties displayed by the individual parts of a compound undergoing construction in a modular manner.
Effect of electrolytes on the slow aggregation of TiO2 nanocrystals (2009)

We studied the slow aggregation of dilute TiO2 hydrosols containing narrow fractions of nanocrystals separated from polydisperse sol by the stepwise coagulation with portions of HCl. It is shown that the kinetics of this process and the structure of formed aggregates greatly depend on the ionic strength and the pH of a medium. It is suggested that, in the presence of various electrolytes, the aggregation proceeds by an identical mechanism. In this case, highly ordered aggregates are formed in which there are thin layers of medium between TiO2 nanocrystals.
Development Of E Team To Commercialize Engineering Research (2020)

An E-Team of biosystems engineering graduate students was formed at Michigan State University for the purpose of exploring the commercialization potential of a biosensor that can be used for rapid detection of foodborne pathogens. The paper presents the benefits and challenges the students encountered throughout the process of implementing the E-Team's objectives. Developing and maintaining a business plan, performing a market analysis, partnering with government and industry, dealing with conflicts of interest in an educational environment, managing product development, searching for funding sources and securing intellectual property were all challenges encountered in the process. The E-Team was successful in putting together a business plan, developing a prototype and securing a small amount of start up funds through competitive grants and competitions. However, the E-Team was unable to secure the intellectual property rights. Overall, the process of commercialization was an excellent educational experience for all members of the E-Team. Although commercialization did not materialize, the learning benefits were tremendous and invaluable.
High Power Metasurface Reflectarray Antennas Using Switched Shorted Circular Elements (2017)

A metamaterial design that can rapidly reconfigure its reflection phase angle and safely operate under high incident field strengths is presented for use in a high power microwave (HPM) reflectarray system. The design offers switching between reflection phase angles to allow for beam control with a stationary reflector and feed horn. Two variations of the design are presented which offer (a) fixed (but selectable) reflection phases with high-power operation and (b) on-the-fly reconfigurable reflection phases with low-power operation. For design (b), reconfiguration is easily and quickly accomplished though simple relay-style switching operation. The designs are developmental steps towards a fully on-the-fly reconfigurable reflectarray which can operate with several megawatts of peak input power. Fabrication and testing of the prototype antennas and metasurfaces were carried out and presented.
Supplementary Data Legends 1-3 from &lt;i&gt;Podoplanin&lt;/i&gt; Is a Novel Fos Target Gene in Skin Carcinogenesis (2023)

Supplementary Data Legends 1-3 from &lt;i&gt;Podoplanin&lt;/i&gt; Is a Novel Fos Target Gene in Skin Carcinogenesis
Improved efficacy/safety profile of factor XIa inhibitor BMS‐724296 versus factor Xa inhibitor apixaban and thrombin inhibitor dabigatran in cynomolgus monkeys (2021)

BMS-724296 produced similar antithrombotic efficacy as apixaban and dabigatran but with no increase in KBT in NHPs. These findings suggest that FXIa inhibitors may provide safe and effective antithrombotic therapy.
Word segmentation through cross-lingual word-to-phoneme alignment (2012)

We present our new alignment model Model 3P for cross-lingual word-to-phoneme alignment, and show that unsupervised learning of word segmentation is more accurate when information of another language is used. Word segmentation with cross-lingual information is highly relevant to bootstrap pronunciation dictionaries from audio data for Automatic Speech Recognition, bypass the written form in Speech-to-Speech Translation or build the vocabulary of an unseen language, particularly in the context of under-resourced languages. Using Model 3P for the alignment between English words and Spanish phonemes outperforms a state-of-the-art monolingual word segmentation approach [1] on the BTEC corpus [2] by up to 42% absolute in F-Score on the phoneme level and a GIZA++ alignment based on IBM Model 3 by up to 17%.
Modification of vibrational damping times in thin gold films by self-assembled molecular layers (2011)

The mechanical contact between a thin gold film and a silicon substrate is investigated by ultrafast pump-probe spectroscopy providing quantitative values on the damping time of coherent longitudinal vibrations of the gold film. A distinct increase in damping times is observed when a self-assembled molecular layer is introduced between the gold film and the substrate. We deduce the frequency dependence of the damping times by varying the thickness of the gold films. Experimental results are compared to numerical simulations based on a visco-elastic model and the acoustic mismatch model.
Human amniotic membrane extracellular matrix scaffold for dental pulp regeneration <i>in vitro</i> and <i>in vivo</i> (2021)

The 30 mg/ml HAM ECM scaffold had optimal physical properties and better supported hDPSC migration. The HAM ECM scaffold did not interfere with formation of pulp-like tissue and revascularization within the root canal when employed as both cell-free and cell-loaded scaffold. These results highlight the potential of HAM ECM membrane for further investigations in regenerative endodontics.
Distribution of Heavy Metals in the Liver of Foetuses andFemale Mice after Oral Administration during Pregnancy, aHistochemical Study (2010)

The aim of this work was to study the distribution of heavy
metals and of subsequently developed morphological changes in
the liver of female mice and their foetuses after oral
administration of high doses of lead, mercury, and cadmium
(0.03 mg of metal per mouse and day). Heavy metals were
administered to pregnant female mice on days 9 to 20 of
pregnancy. The animals were euthanised by cervical dislocation.
Samples of mother and foetal liver were subsequently collected
and processed by means of the common technique for light and
electron microscopy. Histochemical reaction based on metal
conversion into appropriate sulphide that conjugates with
silver was used for detection of heavy metals. Deposits of
heavy metals were found at the periphery of lobules of the
central vein in the liver of female mice. On the contrary, in
the liver of foetuses no predilection site for localisation of
the reaction product could be identified. At the electron
microscopy level, accumulation of heavy metals was connected as
a rule with the occurrence of a certain damage to some
organelles. Deposits of the reaction product were located above
all in hepatocytes and Kupffer cells. Heavy metals were bound
to the heterochromatin of cell nuclei, as well as to some
cytoplasmic organelles, such as rough endoplasmic reticulum,
mitochondria, ribosomes, and lysosomes. The presence of heavy
metals was associated with obliteration of cisternae of the
rough endoplasmic reticulum, separation of ribosomes, and
destruction of lysosomes. Vacuolation of cell cytoplasm was
also a frequent phenomenon. An interesting finding was the
contrasting of structures containing nucleic acids.
Accumulation of metals in the liver of pregnant mice and their
foetuses observed in our study indicated that placental barrier
does not protect the foetal organism against penetration of
metals. Their higher accumulation in foetal compared to
maternal liver can be explained by intense metabolism of
differentiating hepatocytes.
Asymmetrical hysteresis in exchange-biased multilayers with out-of-plane applied fields (2005)

The angular dependence of exchange bias with the applied field parallel to the film plane has been well established. Here we report on the characteristics of exchange bias with the field rotated out of the film plane at angle $\ensuremath{\theta}$ from the film plane. The hysteresis loop shifts from the origin not only along the field axis but also along the magnetization axis. Both ${H}_{E}$ and ${H}_{C}$ increase with a $1∕\mathrm{cos}\phantom{\rule{0.2em}{0ex}}\ensuremath{\theta}$, which can be accounted by considering the angular dependence of anisotropy introduced during the field cooling.
Energy scaling of ultrafast fiber systems using chirped and divided pulse amplification (2013)

The technique known as chirped pulse amplification (CPA) is the most popularly used technique to scale the energy of ultrashort amplification systems. This technique consists in stretching and compressing the pulse upstream and downstream the amplifier to mitigate various deleterious effects and still recover ultrashort pulse duration. However, its implementation is increasingly difficult and costly when the desired stretched pulse duration is greater than 1 ns, due to the increasing size of the gratings and overall optical setup. Such long stretched pulse duration is therefore not used for compact tabletop or industrial systems. The divided-pulse amplification (DPA) idea was proposed more recently [1], and is similar to CPA in the sense that it also consists in redistributing the pulse energy over a time interval larger than the initial pulsewidth to reduce the peak power. In this scheme, a train of several orthogonally polarized delayed pulse replicas is generated and amplified, before final recombination. In this contribution, we propose and demonstrate for the first time to our knowledge a femtosecond fiber amplifier that uses both concepts simultaneously to scale the output energy of a compact (1.2 m × 0.4 m <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</sup> ) femtosecond fiber system. The experimental arrangement is depicted in Fig. 1. The DPA setup is included inside a moderately nonlinear fiber CPA in which the impact of nonlinearities can be partially compensated by the dispersion mismatch of the stretcher and compressor units [2]. Temporal pulse divisions are implemented using two free-space Mach-Zehnder interferometers in which the splitting and recombining elements are thin-film polarizers. Depending on the orientation of the input linear polarization, the power fraction sent in each arm can be adjusted. In particular, one arm can be completely bypassed, reducing the number of replicas generated. The arm length differences in both interferometers are 1.32 m and 0.66 m respectively. On the way to the amplifier, this arrangement therefore generates a train of up to 4 orthogonally polarized chirped pulse replicas separated by a delay of 2.2 ns and be equivalent to a stretching ration > 2 ns.
Species Classification by the Support Vector Machine Using the Broadband Split-Beam (2014)

Species classification using an acoustic sounder is important for fisheries. With schools of mixed species, it is necessary to be able to classify individual fish species from echoes, and to isolate individual fish echoes. A broadband signal, which offered the advantage of high-range resolution, was applied for this purpose, and the positions of fish were estimated using the split-beam system. The target strength (TS) spectrum of individual fish echoes was computed from isolated echoes and estimated positions. In this paper, these TS spectra were used as features of fish classification for machine learning. Also, it is well known that the TS spectra are dependent on not only fish species but on fish size. Therefore, it is necessary to classify both fish species and size using these features. We attempted to classify two species and two fish sizes using the Support Vector Machine (SVM) and Nearest Neighbor Algorithm (NNA) as machine learning. Subject species were chub mackerel (Scomber japonicas) and Japanese jack mackerel (Trachurus japonicus). The classification rates using the SVM were superior to those using the NNA. These rates were dependent on the frequency bandwidth and tilt angle. The classification rate was 71.6% with limitation of the tilt angles.