gebhart/patrepeval huggingface dataset:
Decentralized Control of Print Registration in Roll-to-Roll Printing Presses (2013)

Roll-to-roll (R2R) manufacturing is a type of continuous manufacturing process extensively used to produce a wide variety of consumer products, such as plastics, paper, films, non-wovens, textile, etc. Recent advances in nanotechnology and material science have enabled the possibility of manufacturing electronics on a flexible substrate using R2R printing techniques. Even though the feasibility of printing electronics on flexible substrates has been extensively studied, continuous printing on a moving substrate using R2R techniques has not been adequately investigated. To facilitate progress towards high precision R2R printing, a systematic investigation of the various aspects that affect print quality and ways in which those can be influenced by different control configurations facilitated by choice and location of various components of the print section is necessary. In this paper we investigate two common control configurations for R2R printing based on the structure of the R2R print section and various components available for control. For these two configurations we develop a state-space model that contains both state and input delays. We propose a decentralized, memoryless, state feedback control law for both control configurations and show the stability of the closed loop systems using frequency domain delay-dependent stability conditions. These control configurations are evaluated and compared using model simulations and discussions on the effectiveness of each strategy are provided.
Supplementary Material from &lt;i&gt;HSP70&lt;/i&gt; Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer (2023)

&lt;p&gt;Supplementary protocol, figure legends and tables. Supplementary Table S1. Cumulative Equivalent Minutes; Supplementary Table S.2 The top 20 genes upregulated by MFH at 43ËšC and 30 min; Supplementary Table S.3 The top 10 genes downregulated by MFH at 43ËšC and 30 min; Supplementary Tables S.4 IC50 values of PES in ovarian cancer cell lines; Supplementary Table S.5 Combination index parameters from CompSyn; Supplementary Table S.6 Combination index values for HeyA8 cells treated in combination with various concentrations of PES and various exposure times of MFH at 43ËšC; Supplementary Table S.7 HSPA6 RNA interference and MFH decreased subcutaneous HeyA8 P values from relative tumor volume. The P values were calculated using the nonparametric test Mann-Whithey.&lt;/p&gt;
SLUG transcription factor: a pro-survival and prognostic factor in gastrointestinal stromal tumour (2017)

GIST patients with high tumour SLUG expression have unfavourable RFS. SLUG may mediate pro-survival signalling in GISTs.
Per Sub-Block Equalization of Very Long OFDM Blocks in Mobile Communications (2010)

In orthogonal frequency division multiplexing (OFDM) communication systems mobility results in time-variations of the channel, which yield intercarrier interference (ICI), especially when large OFDM blocks are employed in order to achieve a high spectral efficiency. In this letter we focus on systems with very long OFDM blocks, where many of the existing ICI mitigation techniques can not be applied due to complexity constraints. To mitigate ICI we propose a pre-equalizer, operating on sub-blocks of the received OFDM block, whose aim is to force all sub-blocks to have almost the same equivalent channel. In other words, the pre-equalizer combats only time variations of the channel. Next, after OFDM demodulation, the classical equalizer compensates frequency selectivity of the target channel. Performance of the proposed scheme, together with a suitable channel estimate implemented on a per sub-block basis, is evaluated for a digital video broadcasting scenario, according to the DVB-T2 standard, where the OFDM block size may be 32k, and its possible extension to hand-held devices in a next-generation DVB-H.
A Protocol for the Optimization of Lateral Flow Immunoassay Strip Development (2023)

Background: Lateral flow immunoassay (LFIA) is a well-known method because of its extensive application in many fields, such as medical, food safety, and environmental analysis. LFIA is also under development for pathogen or protein detection, where rapid detection is essential. However, there are few studies on the optimal process for LFIA production. Methods: This study aimed to evaluate the roles of the different materials that make up the LFIA strip, consisting of the sample pad, conjugate pad, nitrocellulose membrane, and absorbent pad. Different membranes and pads were evaluate regarding membrane permeability, generation of the test line, capillary flow time, and result visibility. Results: The results indicated that the optimized LFIA strip is composed of four membranes and pads, including the CF3 sample pad, FF170HP nitrocellulose membrane immobilized with 1 mg of antibody, Standard 17 conjugate pad, and CF6 absorbent pad. The result was visually detectable within 15 minutes. Conclusion: This optimization protocol could be a reference for the development of new test strips.
Oxygen Permeability Measurements on Elastomers at Temperatures up to 225 °C (2005)

Oxygen permeability data, vital parameters for understanding and modeling the thermooxidative degradation of polymers, have been determined for various elastomers. Using a novel experimental setup, oxygen permeability through sheet materials was measured for elevated temperatures up to 225 °C. Under these conditions oxygen can react with the polymer reducing the effective O2 flux. Knowing the relevant oxidation rates makes it possible to correct the permeability measurements for thermal oxidation occurring during permeation. A theoretical model using iterative data processing to determine true permeability data was developed to compensate for the oxidative loss of oxygen. The applicability to data collection and mathematical treatment for a range of materials is demonstrated. All permeability measurements exhibit curvature for an Arrhenius plot with activation energies being highly dependent on temperature.
Immunoelectron microscopy of the connective tissue matrix following cryotechnical processing (1995)

Our understanding of the microarchitecture of connective tissues is based primarily on micrographs taken of tissues stabilized by immersion fixation. Considerable extraction of tissue components, particularly small matrix molecules, occurs even during fixation in glutaraldehyde. An alternative to immersion fixation is the technique of cryostabilization whereby tissue components are instantaneously immobilized and surrounded by non-crystaline (amorphous) or microcrystaline ice. The ice is replaced at low temperature (-100 to -85°C) by acetone containing fixative, and the tissue finally embedded in epoxy. A comparison of micrographs taken from tissue embedded following immersion fixation and those taken following cryotechnical processing reveals striking differences in the structure of cells, basement membranes, and matrix (Fig. 1a and 2a). Our recent objective has been to utilize sections from samples which have been stabilized by high pressure freezing for immunocytochemical labeling experiments with the expectation that such studies would result in a more precise localization of matrix components. The results to date suggest that many of the difficulties normally experienced in section surface labeling technique are still a problem: Antigens may be affected by the chemistry of freeze-substitution and choice of embedding media.
Advanced Development of Space Photovoltaic Concentrators Using Robust Lenses, Multi-Junction Cells, &amp; Graphene Radiators (2018)

At the past three PVSCs [1]–[3], our team has presented recent advances in our space photovoltaic concentrator technology. In the past year, under multiple NASA-funded research and technology development programs, our team has made much additional progress in the advanced development of space photovoltaic concentrators. New robust Fresnel lenses, new high-efficiency multi-junction cells, and new graphene radiators have been developed. The paper will present the latest advances in this technology.
Probabilistic Load Flow Method for Correlated Multimodally Distributed Input Variables (2018)

Due to growing uncertainties in the electricity grid, probabilistic load flow methods have achieved more attention. The Point Estimate Method (PEM) was introduced in 1975 and was enhanced since then. Within this method, statistical moments of the output variables are calculated. Afterwards, the probability density functions (PDF) and cumulative density functions (CDF) are determined using expansion methods. Nowadays, Cornish-Fisher-, Edgeworth-and Gram-Charlier-Expansion- (GCE) Methods are mainly used. Due to the combination of different renewable energy sources (RES) at the same grid node, correlated multimodally distributed input variables may result. The existing approaches of PEM and their expansion methods can only deal with normally or close to normally distributed input variables. This paper shows an enhancement to the two-PEM (2m-PEM) and GCE method in order to consider correlated multimodally distributed input variables. The proposed algorithm is demonstrated in a test grid and verified through the comparison of the results using Monte Carlo Simulation (MCS) as reference method.
Performance of GNSS Beamforming Algorithms using Distributed Sub-arrays in Automotive Applications (2018)

Antenna array systems have been proven suitable to counteract radio frequency interference. The large size of uniform rectangular arrays with half-wave antenna spacing for the GNSS frequency bands impedes an installation in the consumer automotive area, where aesthetic design is a unique selling point and hence desired by the industry and its customers. This paper emphasizes a new approach, where a conventional uniform rectangular array is split into distributed sub-arrays. Care must be taken by the geometrical arrangement of the sub-arrays, as the array manifold and hence the DOA-estimation may become ambiguous, possibly leading to an accidential mitigation of incident satellite signals. Design rules for the distributed sub-arrays are therefore derived and the impact of the proposed array on beamforming algorithms on the example of RFI mitigation is discussed. The theoretical models of the respective antenna patterns are verified by measurements.
A review of the atypical manifestations of gastroesophageal reflux disease (2004)

Manifestations of atypical gastroesophageal reflux disease (GORD) are varied, and the presentation of atypical symptoms may occur in the absence of typical symptoms. The most sensitive and specific investigation for GORD is pH monitoring, and its application in atypical disease is utilized throughout this paper as a basis for correlating disease and pathogenesis. The less well-known areas of laryngeal manifestations, particularly chronic hoarseness and globus, are discussed in addition to recent work on orodental manifestations. Well-known areas of cardiac and respiratory manifestations, which include chronic cough and asthma, are also reviewed. Evidence from clinical trials indicates that aggressive anti-reflux therapy in patients with atypical symptoms can be effective. Where appropriate, medical therapy may involve long-term proton pump inhibitor, although further research outlining the roles of other therapies such as surgery is awaited.
The <i>In Vitro</i> and <i>In Vivo</i> Effects of a Low-Molecular-Weight Fucoidan on the Osteogenic Capacity of Human Adipose-Derived Stromal Cells (2013)

Human adipose-derived stromal cells (hASCs) may hold potential for bone tissue engineering. Osteogenic differentiation of these cells is crucial to bone formation. Low-molecular-weight fucoidan (LMWF) is a sulfated polysaccharide that potentiates several growth factors, including pro-angiogenic growth factors. To investigate whether hASC preconditioning with LMWF promoted bone repair, we compared the effects of LMWF and low-molecular-weight heparin on hASC phenotype and osteogenic differentiation. LMWF did not modify the stem-cell phenotype of hASCs but enhanced their osteogenic differentiation (formation of calcium deposits, increased activity and expression of alkaline phosphatase, and increased expression of osteopontin and runt-related transcription factor 2). However, when hASCs were exposed to LMWF before their adhesion to biphasic calcium phosphate particles and implantation in a bone-growth mouse model, no bone formation was apparent after 5 or 8 weeks, probably due to cell death. In conclusion, LMWF may hold promise for enhancing the osteogenic differentiation of hASCs before their implantation. However, concomitant vascularization would be required to enhance bone formation.
Yihx-encoded haloacid dehalogenase-like phosphatase HAD4 from Escherichia coli is a specific α-d-glucose 1-phosphate hydrolase useful for substrate-selective sugar phosphate transformations (2014)

Phosphomonoester hydrolases (phosphatases; EC 3.1.3.) often exhibit extremely relaxed substrate specificity which limits their application to substrate-selective biotransformations. In search of a phosphatase catalyst specific for hydrolyzing α-d-glucose 1-phosphate (αGlc 1-<i>P</i>), we selected haloacid dehalogenase-like phosphatase 4 (HAD4) from <i>Escherichia coli</i> and obtained highly active recombinant enzyme through a fusion protein (Z<sub>basic2</sub>_HAD4) that contained Z<sub>basic2</sub>, a strongly positively charged three α-helical bundle module, at its N-terminus. Highly pure Z<sub>basic2</sub>_HAD4 was prepared directly from <i>E. coli</i> cell extract using capture and polishing combined in a single step of cation exchange chromatography. Kinetic studies showed Z<sub>basic2</sub>_HAD4 to exhibit 565-fold preference for hydrolyzing αGlc 1-<i>P</i> (<i>k</i><sub>cat</sub>/<i>K</i><sub>M</sub> = 1.87 ± 0.03 mM<sup>-1</sup> s<sup>-1</sup>; 37 °C, pH 7.0) as compared to d-glucose 6-phosphate (Glc 6-<i>P</i>). Also among other sugar phosphates, αGlc 1-<i>P</i> was clearly preferred. Using different mixtures of αGlc 1-<i>P</i> and Glc 6-<i>P</i> (e.g. 180 mM each) as the substrate, Z<sub>basic2</sub>_HAD4 could be used to selectively convert the αGlc 1-<i>P</i> present, leaving back all of the Glc 6-<i>P</i> for recovery. Z<sub>basic2</sub>_HAD4 was immobilized conveniently using direct loading of <i>E. coli</i> cell extract on sulfonic acid group-containing porous carriers, yielding a recyclable heterogeneous biocatalyst that was nearly as effective as the soluble enzyme, probably because protein attachment to the anionic surface occurred in a preferred orientation via the cationic Z<sub>basic2</sub> module. Selective removal of αGlc 1-<i>P</i> from sugar phosphate preparations could be an interesting application of Z<sub>basic2</sub>_HAD4 for which readily available broad-spectrum phosphatases are unsuitable.
Relationship of Serum Apolipoprotein A-V Levels, Oxidative Stress and Inflammatory Biomarkers with Hypertriglyceridemia in Type 2 Diabetes Mellitus (2017)

In patients of T2DM, low levels of Apo A-V are associated with HTG, indicating that Apo A-V is linked with TG metabolism. Burden of oxidative stress is greater in HTG of T2DM as is evident from MDA levels and its correlation with TG levels. Since oxidative stress is an important patho-physiological basis which increases the risk of CVD in patients of T2DM with HTG. Further studies are required in order to explore the possible role of Apo A-V in TG metabolism in diabetes.
Analysis of Unknown-Location Signal Detectability for Regularized Tomographic Image Reconstruction (2006)

Our goal is to optimize regularized image reconstruction methods for emission tomography with respect to the task of detecting small lesions of unknown location in the reconstructed images. We consider model observers whose decisions are based on finding the maximum value of a local test statistic over all possible lesion locations. We use tail probability approximations by Adler (AAP 2000) and Siegmund and Worsley (AS 1995) to evaluate the probabilities of false alarm and detection respectively for the observers of interest. We illustrate how these analytical tools can be used to optimize regularization with respect to the performance (at low probability of false alarm operating points) of a maximum channelized non-prewhitening observer
Data from RAF265 Inhibits the Growth of Advanced Human Melanoma Tumors (2023)

&lt;div&gt;Abstract&lt;p&gt;&lt;b&gt;Purpose:&lt;/b&gt; The purpose of this preclinical study was to determine the effectiveness of RAF265, a multikinase inhibitor, for treatment of human metastatic melanoma and to characterize traits associated with drug response.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Experimental Design:&lt;/b&gt; Advanced metastatic melanoma tumors from 34 patients were orthotopically implanted to nude mice. Tumors that grew in mice (17 of 34) were evaluated for response to RAF265 (40 mg/kg, every day) over 30 days. The relation between patient characteristics, gene mutation profile, global gene expression profile, and RAF265 effects on tumor growth, mitogen-activated protein/extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) phosphorylation, proliferation, and apoptosis markers was evaluated.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Results:&lt;/b&gt; Nine of the 17 tumors that successfully implanted (53%) were mutant BRAF (&lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;V600E/K&lt;/sup&gt;), whereas eight of 17 (47%) tumors were BRAF wild type (&lt;i&gt;BRAF&lt;sup&gt;WT&lt;/sup&gt;&lt;/i&gt;). Tumor implants from 7 of 17 patients (41%) responded to RAF265 treatment with more than 50% reduction in tumor growth. Five of the 7 (71%) responders were &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;WT&lt;/sup&gt;, of which 1 carried &lt;i&gt;c-KIT&lt;sup&gt;L576P&lt;/sup&gt;&lt;/i&gt; and another &lt;i&gt;N-RAS&lt;sup&gt;Q61R&lt;/sup&gt;&lt;/i&gt; mutation, while only 2 (29%) of the responding tumors were &lt;i&gt;BRAF&lt;/i&gt;&lt;sup&gt;V600E/K&lt;/sup&gt;. Gene expression microarray data from nonimplanted tumors revealed that responders exhibited enriched expression of genes involved in cell growth, proliferation, development, cell signaling, gene expression, and cancer pathways. Although response to RAF265 did not correlate with pERK1/2 reduction, RAF265 responders did exhibit reduced pMEK1, reduced proliferation based upon reduced Ki-67, cyclin D1 and polo-like kinase1 levels, and induction of the apoptosis mediator BCL2-like 11.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Conclusions:&lt;/b&gt; Orthotopic implants of patient tumors in mice may predict prognosis and treatment response for melanoma patients. A subpopulation of human melanoma tumors responds to RAF265 and can be characterized by gene mutation and gene expression profiles. &lt;i&gt;Clin Cancer Res; 18(8); 2184–98. ©2012 AACR&lt;/i&gt;.&lt;/p&gt;&lt;/div&gt;
Active flow control on an Ahmed body - An experimental study (2015)

25 Ahmed model for the purpose of controlling aerodynamics. The application of steady microjet actuators in multiple congurations are investigated through a series of experimental studies. Each arrays’ location is selected to target key ow features, e.g. the slant separation bubble, the trailing wake vortices, and the c-pillar vortices. These are independently targeted in an eort to understand their response to control as well as their impact on overall aerodynamics. The ow’s response is characterized by aerodynamic force measurements, mean surface pressures, and velocity eld measurements. Actuation of a control array just downstream of the slant edge was shown to be one of the most eective control congurations achieving a reduction in drag of up to 13%. A tandem control method, where two arrays are actuated simultaneously was able to further reduce the maximum drag reduction for a single array by up to an additional 2%.
Development of a New Approach to Determine the Potency of Bacille Calmette–Guérin Vaccines Using Flow Cytometry (2017)

This study contributes to the evaluation of new potency test method for FACS-based determination of viable cells in BCG vaccines. Accordingly, quality control of BCG vaccines can be significantly improved.
Caracterisation des molecules d'adherence et des lymphocytes intra-epitheliaux au cours des maladies inflammatoires du tube digestif (1997)

La physiopathogenie des maladies inflammatoires intestinales est mal connue. On distingue les maladies inflammatoires chroniques intestinales (mici), caracterisees par un infiltrat de cellules inflammatoires dans le chorion et la sous-muqueuse ou le recrutement des leucocytes circulants fait probablement intervenir certaines molecules d'adherence vasculaire, et la maladie cliaque caracterisee par un infiltrat intra-epithelial de lymphocytes t qui suggere un role pathogene de ces derniers. Nous avons mis en evidence au cours de la rectocolite hemorragique (rch), par des techniques immuno-histochimiques sur coupes congelees, qu'il existait une correlation statistiquement significative entre les parametres cliniques, endoscopiques et histologiques ainsi qu'avec l'evolutivite de la maladie et l'expression vasculaire de e-selectine, mais non d'icam-1 et -3 ou de vcam-1. Au cours de la maladie de crohn colique (mc) et de la rch nous avons montre de plus qu'il existait une expression differentes entre ces deux entites proches. Cd44s et cd44v6 etaient exprimes par les cellules epitheliales coliques frequemment au cours de la rch et rarement au cours de la mc ou il existait une expression de cd44v9 par les cellules glandulaires. Au cours de la maladie cliaque resistante au regime sans gluten, nous avons mis en evidence sur coupes congelees et sur biopsies fraiches, la presence d'une population intestinale de lymphocytes intra-epitheliaux (lie) anormale avec expression intracytoplasmique du cd3, absence des recepteurs de surface habituels cd4, cd8 et tcr, associee a une configuration restreinte du rearrangement du tcr qui pourrait suggerer un potentiel lymphomateux. Sur coupes fixees, cette population de lie a pu etre mise en evidence par une etude immunohisto-chimique simplifiee avec expression du cd3 et absence de detection du cd8 et permettra des etudes retrospectives sur une plus grande echelle.
Systematic Study on the Sensitivity Enhancement in Graphene Plasmonic Sensors Based on Layer-by-Layer Self-Assembled Graphene Oxide Multilayers and Their Reduced Analogues (2015)

The use of graphene in conventional plasmonic devices was suggested by several theoretic research studies. However, the existing theoretic studies are not consistent with one another and the experimental studies are still at the initial stage. To reveal the role of graphenes on the plasmonic sensors, we deposited graphene oxide (GO) and reduced graphene oxide (rGO) thin films on Au films and their refractive index (RI) sensitivity was compared for the first time in SPR-based sensors. The deposition of GO bilayers with number of deposition L from 1 to 5 was carried out by alternative dipping of Au substrate in positively- and negatively charged GO solutions. The fabrication of layer-by-layer self-assembly of the graphene films was monitored in terms of the SPR angle shift. GO-deposited Au film was treated with hydrazine to reduce the GO. For the rGO-Au sample, 1 bilayer sample showed a higher RI sensitivity than bare Au film, whereas increasing the rGO film from 2 to 5 layers reduced the RI sensitivity. In the case of GO-deposited Au film, the 3 bilayer sample showed the highest sensitivity. The biomolecular sensing was also performed for the graphene multilayer systems using BSA and anti-BSA antibody.