gebhart/patrepeval huggingface dataset:
Mycophenolate mofetil, with cyclosporine and prednisone, reduces early rejection while allowing the use of less antilymphocytic agent induction and cyclosporine in renal recipients with delayed graft function (2000)

Antilymphocytic agent induction (ALAI), with antithymocyte globulin or monoclonal antibody, is generally used in renal transplantation (TX) to spare renal allografts with poor initial function from the toxic effects of cyclosporine (CsA) and/or to augment immunosuppression (IS) in the patient at a high risk for early rejection. ALAI, unfortunately, increases the cost of TX and the risk to the patient, having been associated with many adverse side effects. An IS protocol, which results in a low incidence of early rejection while using less CsA and ALAI, is a worthwhile goal. We compare our experience with mycophenolate mofetil (MMF), CsA, and prednisone (MMFCP; n = 62) to our azathioprine (AZA), CsA, and prednisone (AZACP; n = 50) triple-drug IS, with and without ALAI. The patient characteristics for age, race, first TX, cadaveric donor, pediatric recipient, and dialysis in the first post-op week (DGF) were not different for the MMFCP versus AZACP groups. There were more females in the MMFCP group (51.6% versus 30.0%, p = 0.022). We report that rejection-free survival at 6 months (RF6) was better in the MMFCP versus AZACP group (83.9% versus 60.0%, p = 0.005). Less ALAI and CsA were used in the MMFCP patients. At 1 year, actuarial graft survival was 91.9% in the MMFCP group and 81.9% in the AZACP group (p = 0.116). Actuarial 1-year patient survivals were not different in the two patient groups. In the sub-population of patients with DGF, the RF6 in the MMFCP (n = 13) group was 92.3% versus 57.1% in the AZACP (n = 14) group (p = 0.041). The reduction in early rejection episodes in the patients on MMFCP with DGF was accomplished while using half as much ALAI and lower CsA doses and levels. The African-American recipient sub-population on MMFCP also demonstrated an improvement in RF6 while using less ALAI and CsA (78.6% versus 48.0%, p = 0.022). We conclude that the use of MMF-based triple-drug IS results in fewer rejection episodes while allowing for lower CsA levels and less ALAI, even in patients with delayed graft function.
Integrated aquaculture contributes to the transfer of mcr-1 between animals and humans via the aquaculture supply chain (2019)

MCRPEC were highly prevalent in the aquaculture supply chain, with the isolates showing resistance to most antibiotics. The data suggested mcr-1 could be transferred to humans via the aquatic food chain. Taking the "One Health" perspective, aquaculture should be incorporated into systematic surveillance programs with animal, human, and environmental monitoring.
Improved critical current density in DI-BSCCO (2010)

High Ic in DI-BSCCO has been demonstrated even in high temperature up to 90K and parallel magnetic field up to 200 mT. This performance is advantageous especially to power cables cooled with pressurized liquid nitrogen, where current and temperature fluctuates in real operation. Recent development has updated the highest Jc at 77K, self-field to 630 A/mm2 in a R&D tape. The evaluation by a scanning magnetic microscope has demonstrated the highest Jc of 900 A/mm2 at the midst of a tape which has Ic of 200 A. This property promises innovative Ic more than 300 A in future DI-BSCCO.
Dural Graft-Induced Fibrotic Mass Twelve Years after Successful Treatment of Skull Base Non-Hodgkin Lymphoma Mimicking Recurrence: Case Report and Literature Review (2013)

Non-Hodgkin lymphoma involving the skull base is a very rare tumour. The role of surgery for these patients remains controversial, as is the use of dural graft for CSF leak repair. With an increasing incidence of CNS lymphoma, more atypical presentations are reported. It is, therefore, important to include lymphoma in the differential diagnosis of skull base lesions as long-term remission is achievable for such patients, as shown in our case. Dural graft used for CSF leak repair could present with delayed complication mimicking tumour recurrence. Relevant published literature is reviewed.
Supplementary Figure Legends from Targeting of PYK2 Synergizes with EGFR Antagonists in Basal-like TNBC and Circumvents HER3-Associated Resistance via the NEDD4–NDRG1 Axis (2023)

&lt;p&gt;Legends for supplementary figures&lt;/p&gt;
(Invited) Guided Nanowire Optoelectronics (2017)

The large-scale assembly of NWs with controlled orientation on surfaces remains one challenge toward their integration into practical devices. During the last few years we reported the growth of perfectly aligned, millimeter-long, horizontal NWs of GaN [1], ZnO [2], ZnSe [3], ZnTe [4], CdSe [5] and other materials, with controlled crystallographic orientations on different planes of sapphire [1-5], SiC [6], quartz [7], and spinel [8]. The growth directions and crystallographic orientation of the NWs are controlled by their epitaxial relationship with the substrate, as well as by a graphoepitaxial effect that guides their growth along surface steps and grooves. As a proof of concept for future applications, we demonstrated the massively parallel “self-integration” of NWs into circuits via guided growth [9]. Here we will show how guided nanowires with complex morphologies and heterostructures can be used for the bottom-up fabrication of nano-optoelectronic devices, including photodetectors, photodiodes and photovoltaic cells [10]
Accelerated Porcine Wound Healing after Treatment with α-Gal Nanoparticles (2012)

α-Gal nanoparticle treatment of wounds accelerates macrophage recruitment, angiogenesis, and wound healing in pigs producing the anti-Gal antibody. As humans produce high titers of anti-Gal antibodies, this treatment may exhibit a similar beneficial effect in the clinical setting.
Complexity in electro-optic delay dynamics: modelling, design and applications (2013)

Nonlinear delay dynamics have found during the last 30 years a particularly prolific exploration area in the field of photonic systems. Besides the popular external cavity laser diode set-ups, we focus in this article on another experimental realization involving electro-optic (EO) feedback loops, with delay. This approach has strongly evolved with the important technological progress made on broadband photonic and optoelectronic devices dedicated to high-speed optical telecommunications. The complex dynamical systems performed by nonlinear delayed EO feedback loop architectures were designed and explored within a huge range of operating parameters. Thanks to the availability of high-performance photonic devices, these EO delay dynamics led also to many successful, efficient and diverse applications, beyond the many fundamental questions raised from the observation of experimental behaviours. Their chaotic motion allowed for a physical layer encryption method to secure optical data, with a demonstrated capability to operate at the typical speed of modern optical telecommunications. Microwave limit cycles generated in similar EO delay oscillators showed significantly improved spectral purity thanks to the use of a very long fibre delay line. Last but not least, a novel brain inspired computational principle has been recently implemented physically in photonics for the first time, again on the basis of an EO delay dynamical system. In this latter emerging application, the computed result is obtained by a proper 'read-out' of the complex nonlinear transients emerging from a fixed point, the transient being issued by the injection of the information signal to be processed.
Novel Non‐Covalent Azaphenylalanine Thrombin Inhibitors with an Aminomethyl or Amino Group at the P1 Position (2004)

Abstract For Abstract see ChemInform Abstract in Full Text.
Metabolism of peptide reporters in cell lysates and single cells (2020)

The stability of an Abl kinase substrate peptide in a cytosolic lysate and in single cells was characterized. In the cytosolic lysate, the starting peptide was metabolized at an average initial rate of 1.7 ± 0.3 zmol pg−;1 s−;1 with a t1/2 of 1.3 min. Five different fragments formed over time; however, a dominant cleavage site was identified. Multiple rational design cycles were utilized to develop a lead peptide with a phenylalanine and alanine replaced by an (N-methyl)phenylalanine and isoleucine, respectively, to attain cytosolic peptidase resistance while maintaining Abl substrate efficacy. This lead peptide possessed a 15-fold greater lifetime in the cytosolic lysate while attaining a 7-fold improvement in kcat as an Abl kinase substrate compared to the starting peptide. However, when loaded into single cells, the starting peptide and lead peptide possessed nearly identical degradation rates and an altered pattern of fragmentation relative to that in cell lysates. Preferential accumulation of a fragment with cleavage at an Ala-Ala bond in single cells suggested that dissimilar peptidases act on the peptides in the lysate versus single cells. A design strategy for peptide stabilization, analogous to that demonstrated for the lysate, should be effective for stabilization in single cells.
Supplementary Figure 4 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells (2023)

&lt;p&gt;S4. Targeting Polθ + PARP and Polθ + RAD52 induced dual synthetic lethality against HR -deficient MPN cells.&lt;/p&gt;
(Invited) High-K Dielectrics: A Perspective on Applications from Silicon to 2D Materials (2017)

This article, from the author's perspective, will review some of the historical developments in high-k dielectrics for field effect transistor technology, many presented at the ECS high-k gate dielectric symposia led by Prof. Kar over the years. It is quite impossible to properly account for the extensive research in the field over the last 2 decades in this forum. Therefore, the author seeks to provide some context on the resilience of the electronics materials research in the past, as well as the challenges and opportunities that lie ahead.
Digitized Trust in Human-in-the-Loop Health Research (2018)

In this paper, we propose an architecture that utilizes blockchain technology for enabling verifiable trust in collaborative health research environments. The architecture supports the human-in-the-loop paradigm for health research by establishing trust between participants, including human researchers and AI systems, by making all data transformations transparent and verifiable by all participants. We define the trustworthiness of the system and provide an analysis of the architecture in terms of trust requirements. We then evaluate our architecture by analyzing its resiliency to common security threats and through an experimental realization.
FDIO: a feedback driven controller for minimizing energy in I/O-intensive applications (2013)

The relatively low utilization of servers in data-center environments when running I/O-intensive applications is a key concern for efficiency. Energy optimization, by throttling power consumption, is an essential operational goal. Since processors are the most demanding of the components constituting a server, energy optimization has focused on regulating processor consumption. However, more recently memory and storage are increasingly becoming more demanding, collectively accounting for more than 40% of the overall energy consumption in typical system configurations. We argue that this trend necessitates tracking overall energy consumption rather than focusing on any single component. Although currently only processors expose energy-related controls at a fine granularity, we demonstrate that with a more holistic approach we can obtain significant efficiency benefits. Specifically, our feedback-based controller for Linux detects I/O-intensive phases in workloads, and adjusts processor operating frequencies accordingly, in a more effective manner than the standard CPU governors.
&lt;title&gt;Spectroscopic investigations of dithienyl polyenes&lt;/title&gt; (1999)

To understand the photophysics of nonlinear absorbers, we have investigated the photophysics of a series of di(2- thienyl-3,3',4,4'-butyl)polyenes. Spectroscopic measurements, including UV/Vis, fluorescence, fluorescence lifetimes, fluorescence quantum yields, triplet state lifetime, solvent effects and two-photon absorption coefficient were obtained as a function of the number of double bonds (n equals 1 - 5). Trends in the data reflected the ordering, energy gap between and mixing of <SUP>1</SUP>B<SUB>u</SUB>* and <SUP>1</SUP>A<SUB>g</SUB>* excited state configurations. We investigated the solvatochromism of a series of (alpha) ,(omega) -di(2- dithienyl 3,3',4,4'-butyl) polyenes. Absorption (n equals 1 - 5 double bonds) were collected in a series of aprotic solvents. The absorption energy dispersion effect sensitivity increased smoothly with n, reaching asymptotic behavior as n approached 5. The emission energy had less solvent sensitivity, giving evidence for a polar <SUP>1</SUP>B<SUB>u</SUB>* absorbing state and a nonpolar <SUP>1</SUP>A<SUB>g</SUB>* emitting state. We observed sensitivity of the absorbing and emitting states to solute-solvent dipole-dipole interactions, suggesting the dithienyl polyenes had a polar syn ground state conformation.
Determination of the endothelin-1 recognition sites of endothelin receptor type A by the directed-degeneration method (2017)

G-protein coupled receptors (GPCRs) play indispensable physiological roles in cell proliferation, differentiation, and migration; therefore, identifying the mechanisms by which ligands bind to GPCRs is crucial for developing GPCR-targeting pharmaceutics and for understanding critical biological functions. Although some structural information is available regarding the interactions between GPCRs and their small molecule ligands, knowledge of how GPCRs interact with their corresponding macromolecule ligands, such as peptides and proteins, remains elusive. In this study, we have developed a novel strategy to investigate the precise ligand recognition mechanisms involved in the interaction of endothelin receptor type A (ET<sub>A</sub>) with its ligand, endothelin-1 (ET-1); we call this method "directed degeneration" method. Through flow cytometric screening of a randomized ET<sub>A</sub> library, statistical analysis of the identified sequences, and biochemical studies, the ligand interaction map was successfully obtained.
Should Gynecologists Test for Pain Sensitization? (2017)

Journal of Gynecology and Women’s Health is a peer-reviewed, multidisciplinary, international journal of Juniper group that publishes scientific works within the field of obstetrics, gynecology and women’s health.
Integration of porous silicon with CVD diamond (1995)

An experimental scheme is devised and demonstrated to realize integration of porous silicon with free standing CVD diamond. Laser Raman spectroscopy, atomic force microscopy, photoluminescence spectroscopy and scanning electron microscopy are used to bring out the nature and quality of the integration achieved.
Electronic structure of polycrystalline AMoO3 (A=Sr or Ba) (1999)

Two strong peaks were observed in the electron energy loss spectra of polycrystalline AMoO3 (A=Sr and Ba) perovskites with metallic conductivities. One, observed at 1.7 eV, was attributed to plasmon loss originating from conduction electrons. This explains the reddish color observed. The other, located at ∼5 eV, was attributed to the charge transfer transition from the Mo4d–O2p bonding band to an unoccupied t2g band through photoemission, ultraviolet inverse photoemission, and x-ray absorption near edge structure spectra. No intense peaks were detected in the energy region between the two absorption bands (2.5&amp;lt;hν&amp;lt;3.5 ev), indicating the possibility of application in transparent conductors for the ultraviolet region.
Aqueous extract of walnut (Juglans regia L.) protects mice against cyclophosphamideinduced biochemical toxicity (2003)

Walnut (Juglans regia L.) is extensively used in traditional systems of medicine for treatment of various ailments. It is described as an anticancer, tonic, blood purifier and detoxifier agent. The present study was undertaken to investigate modulatory effects of walnut extract on the toxicity of an anticancer drug, cyclophosphamide (CP) with special reference to protection against disruption of drug metabolizing and antioxidant enzymes. Plant extract+CP group animals showed restoration in the level of cytochrome P450 (CYP) content and in the activities of glutathione S-transferase (GST), glutathione peroxidase (GP) and catalase (CAT) in both liver and kidneys. But plant extract restored the activity of superoxide dismutase (SOD) and the level of reduced glutathione (GSH) in the kidneys only when compared with CP-treated animals. Plant extract treatment alone caused significant reduction in the content of CYP in the kidneys mainly. The extract showed a significant increase in the level of GSH and in the activities of GP in both the tissues and CAT in liver only, whereas no significant change was observed in the activities of GST and SOD. CP treatment resulted in a significant (P < 0.01) increase in the lipid peroxidation (LPO) in the liver and kidneys compared with controls, while the extract+CP treated group showed a significant decrease in the LPO in liver and kidneys when compared with the CP-treated group. The study shows that the use of J. regia extract might be helpful in abrogation of CP toxicity during the chemotherapy.
Geometric Freedom for Constructing Curvilinear and Variable Size Photonic Bandgap Structures (2006)

Summary form only given: In this study two new sub-classes of photonic bandgap materials, a) curvilinear-lattice photonic crystals, whose distinctive feature is that their individual scatterers are arranged in a curvilinear lattice and b) variable size photonic bandgap structures are introduced. We show that adhering to some restrictions in the acceptable lattice transformations; one can achieve omnidirectional photonic bandgaps for the whole area of such structures. We demonstrate, designing an efficient waveguide bend, that curvilinear-lattice photonic crystals can be employed for creation of original types of nano-photonic devices. For variable size photonic bandgap structures the effects of geometrical parameter variation on the properties of photonic crystals is studied. We show that long-range periodicity is not necessary for the formation of bandgaps, which leads to new flexible photonic crystal designs. Using the fact that in systems with large gaps the evanescent waves penetrate into the bulk only distances comparable to one lattice constant and also converting the bandgap maps into width and period set for a given frequency, we are able to use this new freedom for designing new (non periodic) scattering structures exhibiting a stop band
<i>Bacillus anthracis</i>IsdG, a Heme-Degrading Monooxygenase (2006)

Bacillus anthracis, the causative agent of anthrax, utilizes hemin and hemoglobin for growth in culture, suggesting that these host molecules serve as sources for the nutrient iron during bacterial infection. Bioinformatic analyses of the B. anthracis genome revealed genes with similarity to the iron-regulated surface determinant (isd) system responsible for heme uptake in Staphylococcus aureus. We show that the protein product of one of these genes, isdG, binds hemin in a manner resembling the heme binding of known heme oxygenases. Formation of IsdG:hemin complexes in the presence of a suitable electron donor, e.g., ascorbate or cytochrome P450 reductase, promotes catalytic degradation of hemin to biliverdin with concomitant release of iron. IsdG is required for B. anthracis utilization of hemin as a sole iron source, and it is also necessary for bacterial protection against heme-mediated toxicity. These data suggest that IsdG functions as a heme-degrading monooxygenase in B. anthracis.
Real-Time Vision-Based Stiffness Mapping † (2018)

This paper presents new findings concerning a hand-held stiffness probe for the medical diagnosis of abnormalities during palpation of soft-tissue. Palpation is recognized by the medical community as an essential and low-cost method to detect and diagnose disease in soft-tissue. However, differences are often subtle and clinicians need to train for many years before they can conduct a reliable diagnosis. The probe presented here fills this gap providing a means to easily obtain stiffness values of soft tissue during a palpation procedure. Our stiffness sensor is equipped with a multi degree of freedom (DoF) Aurora magnetic tracker, allowing us to track and record the 3D position of the probe whilst examining a tissue area, and generate a 3D stiffness map in real-time. The stiffness probe was integrated in a robotic arm and tested in an artificial environment representing a good model of soft tissue organs; the results show that the sensor can accurately measure and map the stiffness of a silicon phantom embedded with areas of varying stiffness.
ChemInform Abstract: Synthesis of Ethylene‐Bridged (N<sup>δ</sup> to N<sup>ω</sup>) Analogues of Arginine. (2000)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
A generation of CMOS readout ASICs for CZT detectors (2000)

As a result of a cooperation between Brookhaven National Laboratory and eV Products a generation of high performance readout ASICs was developed. The ASICs, realized in CMOS 0.5 /spl mu/m technology, are available in several different versions, single or multi-channel and with unipolar or bipolar shaper, in view of their use in research, spectroscopy, medical, safeguard and industrial applications. Four innovative circuit solutions are implemented in the ASICs: (i) a high linearity compensated continuous reset system which self-adapts to a wide range of detector leakage currents with minimum noise contribution; (ii) a high order shaper realized by using the follow-the-leader feedback (FLF) approach; (iii) a class AB rail-to-rail output stage with high driving capability; (iv) a baseline holder (BLH) for the baseline stabilization. The basic structure of the ASICs, a description of the circuit solutions and the preliminary experimental results are reported.
Regulation of Cell Wall Synthesis and Growth (2007)

The replication and growth of Mycobacterium tuberculosis are fundamentally linked to the synthesis and extension of its complex cell wall. Incorporation of new wall material must be tightly regulated so that its deposition does not compromise the extant structure. M. tuberculosis also produces an impressive array of complex bioactive lipids that are intimately involved in pathogenesis and protective immunity. The profiles of these lipids are regulated appropriately to allow the bacterium to respond to the prevailing conditions it faces in vivo. A number of regulatory strategies employed by M. tuberculosis to control cell wall biosynthesis and cell division have now been elucidated. The review highlights the role of alternative sigma factors with extracytoplasmic function in the activation of genes for biosynthesis of complex lipids involved in pathogenicity. Rel(Mtb) and CRP(Mt) play roles in cell wall responses to general nutrient deprivation by synthesis and sensing of starvation second messengers, respectively. Recently, the importance of protein phosphorylation networks in cell wall biosynthesis has attracted considerable interest. A plethora of two-component and eukaryotic-like serine/threonine protein kinases systems have been discovered and several are implicated in cell-division, morphogenesis and regulation of the profile of complex bioactive lipids elaborated by the pathogen.