gebhart/patrepeval huggingface dataset:
Sound Field Control With Hemi-Cylindrical Loudspeaker Arrays (2016)

An acoustical model for the sound field generated by hemi-cylindrical loudspeaker arrays is presented and a method for beamforming with said arrays is derived. The sound field model is obtained by introducing two independent boundary conditions for the sound field of a single impinging plane wave. The model for the radiation from a single loudspeaker in the array is then obtained from the reciprocity principle. Various beam patterns are presented and the theoretically predicted sound field is evaluated as a function of frequency. The results are discussed and an experimental array prototype is presented.
The design and synthesis of non-natural polyenes for the reversal of multidrug resistance (2000)

The Healthy Child Programme (HCP) focuses on the care offered to pregnant women and children in the first five years of life. It is delivered by a range of professionals, with the health visitor as lead. Effective delivery of the HCP depends on services for children and families being fully integrated, and partnership working between different agencies on a local level seems to be the key to success. This article focuses on how effective implementation of the HCP facilitates the recognition and care of women with anxiety, mild to moderate depression and other perinatal mental disorders during both the antenatal period and after the birth.
Sub-20-fs Multiterawatt Lasers (1996)

Recent advances in short pulse oscillator technology have led to the reliable generation of pulses as short as 7-fs in duration[1]. Amplification of such pulses to only modest energies (~1 J), would produce peak powers (100 TW) and peak intensities (&gt;10 21 W/cm 2 ) which are equivalent to or greater than those currently produced by the largest Nd:Glass based laser facilities. Futhermore low-energy, ultrashort-duration, high-peak-power systems could operate at repetition rates that are &gt; 4 orders of magnitude higher, thus opening wide areas of high field, ultrafast phenomena to rapid investigation. Amplification of pulses on the order of 10 fs, however, is severely limited by two concerns: 1) control of higher order phase distortion and 2) gain narrowing during amplification.. In this paper, we present results of a three stage amplification system developed at the University of California, San Diego in which we address these problems with an optimized, quintic-phase-limited expander and compressor design and with regenerative pulse shaping. This system is designed to produce nearly-diffraction-limited, &gt; 1-J pulses of ~15-fs in duration. To date the first two stages of amplification have produced, 18-fs, 4.4-TW pulses at a repetition rate of 50 Hz and an average power &gt; 10 W before compression. To our knowledge, these intermediate results represent the shortest terawatt pulses, the highest expansion ratio (&gt;100,000 times) and the highest average power yet produced by a chirped pulse amplification system.
Cardiac Angiotensin II Receptors Are Upregulated by Long-Term Inhibition of Nitric Oxide Synthesis in Rats (1998)

It has been shown that nitric oxide (NO) may regulate angiotensin II (Ang II) receptors in vitro. To determine whether the chronic inhibition of NO synthesis upregulates cardiac Ang II receptors in a rat model, we evaluated the in vivo effect of Nomega-nitro-L-arginine methyl ester (L-NAME) on several Ang II receptors and on the expression of AT1 receptor mRNA in heart tissue. The chronic administration of L-NAME to normal rats increased the arterial blood pressure. The number of AT1 and AT2 receptors was increased, with no change in affinity, during the first week of L-NAME administration but returned to control levels after 4 weeks of treatment. The AT1 receptor mRNA was changed parallel to AT1 receptor number. Inflammatory changes (monocyte infiltration and myofibroblast formation) in perivascular areas surrounding coronary vessels and myocardial interstitial spaces were observed during the first week. The immunohistochemistry revealed that myofibroblasts expressed AT1 receptor. AT1 receptor blockade or cotreatment with L-arginine, but not cotreatment with hydralazine, prevented the L-NAME-induced increase in Ang II receptors and inflammatory changes. In conclusion, rat cardiac Ang II receptors are upregulated at an early phase of chronic inhibition of NO synthesis. This may contribute to cardiovascular inflammatory changes in an early phase and to remodeling at the later phase, which occurs after inhibition of NO synthesis.
Dual-Frequency Ytterbium-Doped Fiber Laser (2006)

A dual-frequency, 2-cm silica fiber laser with two orthogonal polarizations has been demonstrated. Single-mode operation at each wavelength has been verified. The OSNR is greater than 60 dB with an output power of 43 mW
Leveraging Multi-core Computing Architectures in Avionics (2012)

Multi-core computer architectures are on the forefront in consumer electronics and adaptation in safety-critical applications such as avionics could be beneficial due to their potential increased performance. Yet, there are challenges to deploy cutting edge multi-core architectures for safety-critical applications. New computing architectures are more integrated and optimized for average cases. On the other side, safety-critical applications need to be designed for the worst case. For example, the impact of integrating critical applications is not fully understood yet, especially with respect to execution times of critical paths. This paper proposes and argues an approach to quantify the impact of integration of multiple independent applications onto multi-core platforms and evaluates the approach on a specific potential future avionics computing platform. Evaluation results focusing on execution estimates show that multi-core computers may be used for safety-critical applications, but the worst-case execution time (WCET) can be multiple times slower than the same application running on a single core without other cores running interfering applications. The actual factor is very dependent on the application's use of shared resources like memory.
Carbohydrate-Derived Amino-Alcohol Ligands for Asymmetric Alkynylation of Aldehydes (2005)

[reaction: see text] Conformationally restricted amino alcohols based on carbohydrate scaffolds provide flexible and fine-tuneable libraries that greatly expand the range of ligands available in the Zn(OTf)(2)-mediated addition of alkynes to aldehydes, in some cases with very high stereoselectivities.
Population pharmacokinetics of methylprednisolone in accident victims with spinal cord injury (2004)

This study demonstrated that CSF concentrations of MP were sufficiently high after i.v. administration and reflected the concentrations of unbound drug in plasma. Salivary levels of MP were about 32% of the plasma level and may serve as an easily accessible body fluid for drug level monitoring.
Free Radical Chemistry. Part 9.<sup>1</sup> Approaches to Fluorinated Polyethers—Model Compound Studies (1999)

Abstract Using peroxide, γ‐, and UV‐irradiation, free radical addition reactions of hexafluoropropene to diethers and to 18‐crown‐6 have been investigated and mono‐, di‐, and poly‐adducts have been obtained. Factors influencing these additions, especially polar characteristics of intermediate radicals, have been elucidated. Adducts of 18‐crown‐6 retain a capacity to complex to alkali‐metal ions.
Realistic Real-Time Simulation of RGB and Depth Sensors for Dynamic Scenarios using Augmented Image Based Rendering (2022)

Simulation remains one of the key methods for testing and validation of robotic perception systems and it also becomes increasingly important for training visuomotor policies for autonomous driving or manipulation. Further, as perception pipelines tend to leverage increasing amounts of modalities, it appears vital to simulate additional cues such as depth maps aside from RGB images. To align simulation with real-world observations, it is key to achieve realistic renderings of these maps, which includes the capability of rendering other dynamic objects in the scene. In this work, we propose an approach to real-time simulation of photo-realistic RGB images and sensor-realistic depth maps, that can contain dynamic objects at user-defined locations. Our method employs a selection of static samples of a pre-recorded database and multimodal cues from CAD models that are fused and warped to synthesize new imagery for a target camera pose. We show the efficacy of our method on newly proposed datasets recorded in a variety of different setups.
Carbon Nanotube Membranes for use in the Transdermal Treatment of Nicotine Addiction and Opioid Withdrawal Symptoms (2009)

Transdermal systems are attractive methods of drug administration specifically when treating patients for drug addiction. Current systems however are deficient in therapies that allow variable flux values of drug, such as nicotine for smoking cessation or complex dosing regimens using clonidine when treating opioid withdrawal symptoms. Through the use of functionalized carbon nanotube (CNT) membranes, drug delivery to the skin can be controlled by applying a small electrical bias to create a programmable drug delivery system. Clearly, a transdermal patch system that can be tailored to an individual's needs will increase patient compliance as well as provide much more efficient therapy. The purpose of this paper is to discuss the applicability of using carbon nanotube membranes in transdermal systems for treatment of drug abuse.
Low-pressure, low-temperature hydrogen annealing for nanoscale silicon fin rounding (2006)

In the CMOS technology, silicon rounding technique is often an essential part of fabrication. There have been some studies about hydrogen annealing process in a silicon fin. But the previous studies have been done in relatively large silicon fins (200 nm ~ 1 mum). In this study, effect of hydrogen annealing in a nanoscale fin (30 nm ~ 100 nm) is investigated. There is significant difference between large width fin and small width fin. Especially, in the smaller fin, not only silicon self-diffusion but also silicon etch phenomenon become important.
Inanga: A Song of Survival in a Daughter’s Rwanda (2017)

Book Review| October 01 2017 Inanga: A Song of Survival in a Daughter’s Rwanda Inanga: A Song of Survival in a Daughter’s Rwanda. Produced by Gregory Barz, with Patrick McGovern, associate producer. DVD. Thirty-seven minutes. 2010. CD recording. Twenty-two-page booklet. Distributed by Lime Pulp Records, Nashville, TN. Jason McCoy Jason McCoy Dallas Baptist University Search for other works by this author on: This Site Google Ethnomusicology (2017) 61 (3): 555–557. https://doi.org/10.5406/ethnomusicology.61.3.0555 Cite Icon Cite Share Icon Share Facebook Twitter LinkedIn MailTo Permissions Search Site Citation Jason McCoy; Inanga: A Song of Survival in a Daughter’s Rwanda. Ethnomusicology 1 January 2017; 61 (3): 555–557. doi: https://doi.org/10.5406/ethnomusicology.61.3.0555 Download citation file: Zotero Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All Scholarly Publishing CollectiveUniversity of Illinois PressEthnomusicology Search Advanced Search The text of this article is only available as a PDF. Copyright 2017 by the Board of Trustees of the University of Illinois2017 Article PDF first page preview Close Modal You do not currently have access to this content.
Connection criteria at the distribution network for distributed generation (2007)

The Task Force has elaborated recommendations for technical rules to be integrated in the national distribution grid codes and for the development of international standards, in order to keep a safe operation of power systems with reasonable and economically acceptable requirements for dispersed generation of various types. Emphasis has been placed on criteria that put unnecessary restrictions on DG penetration.
Clinical application of functional profiling in advanced NSCLC and colorectal cancers (2008)

13547 Background: As genomic & proteomic analyses improve the process of drug selection, laboratory techniques that assess drug response at a functional level have the potential to explore novel therapeutic strategies. To assess the predictive validity of a human tumor micro-spheroid platform, phase II trials in previously untreated, Stage IV NSCLC & Colorectal (CRC) cancers were undertaken. Methods: Following mechanical and enzymatic disaggregation, drug induced programmed cell death was assessed by cellular morphology, staining & metabolic changes to identify drug, combination and targeted agent activities. Modified Z-scores ranked drug activity. Synergy was measured by median-effect. The most active and/or synergistic agents were selected for first-line therapy. The trials, powered to improve objective response rate and progression-free-survival also examine QOL and cost of care. To date, 19 NSCLC (17 evaluable) & 11 CRC (10 evaluable) have accrued to the IRB-approved laboratory-directed protocol. Results: See Table. Conclusions: 1) Directed therapy is feasible, with laboratory results provided by the 7th day post-op. 2) Response, PFS and OS compare favorably with the most active treatments in these diseases, with median OS in NSCLC not yet reached. 3) Patients manifest highly “individual” profiles suggesting clinically relevant drug response heterogeneity. 4) The platform is applicable to targeted agents with several NSCLC patients receiving 1st line single agent Erlotinib, all of whom responded. Finally, 5) By assessing all operative mechanisms of drug response and resistance acting in concert, functional profiling may complement analyte-based platforms and provide bio-systematic insights into complex and redundant tumor response pathways. Supported by the Memorial Medical Center Foundation of Long Beach, MHS #408–06. DX N CR PR ORR SD PD Med PFS (m) Med OS (m) NSCLC 17 1 (6%) 8 (47%) 9 (53%) 7 (41%) 1 (6%) 7.2 13.2(+) CRC 10 1 (10%) 6 (60%) 7 (70%) 2 (20%) 1 (10%) 9.8 14.7 Author Disclosure Employment or Leadership Consultant or Advisory Role Stock Ownership Honoraria Research Expert Testimony Other Remuneration Todd Cancer Institute
Semantic Business Analytics in Industrial Facilities - a Case Study. (2009)

Abstract: In the following article we point out the potentials of semantic technologies for an application in the area of business analytics. Semantic Business Analytics as understood by the operators of a power plant means to provide interactive guidelines to advise the operator to take the right steps, and to provide a mechanism to learn from past incidents. Therefore a sensor-based ontology represents a predictive model for the behaviour of mechanical and electrical parts of a power plant under certain circumstances. Rules are crucial in this application, as they represent, as so called monitors, complex relationships between different elements (energy medium, parts of the plant, and environmental influence) and their behaviour in time. Acting as semantic agents, these monitors observe the power plant and create alerts in case of an incident. The alert is used by an ontology-based advisory system which guides the operator how to deal with and fix the problem. The knowledge engineer is able to improve the system by learning from past incidents by analyzing the stored incidents and derive new experience and monitors from. Monitoring systems may be classified as business analytics systems and thus this application shows the benefits of semantic technologies in business analytics respectively business intelligence. 1
Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness (2019)

Acute illness is a complex constellation of responses involving dysregulated inflammatory and immune responses, which are ultimately associated with multiple organ dysfunction. Gene association studies have associated single-nucleotide polymorphisms (SNPs) with clinical and pharmacological outcomes in a variety of disease states, including acute illness. With approximately 4 to 5 million SNPs in the human genome and recent studies suggesting that a large portion of SNP studies are not reproducible, we suggest that the ultimate clinical utility of SNPs in acute illness depends on validation and quality control measures. To investigate this issue, in December 2018 and January 2019 we searched the literature for peer-reviewed studies reporting data on associations between SNPs and clinical outcomes and between SNPs and pharmaceuticals (i.e., pharmacogenomics) published between January 2011 to February 2019. We review key methodologies and results from a variety of clinical and pharmacological gene association studies, including trauma and sepsis studies, as illustrative examples on current SNP association studies. In this review article, we have found three key points which strengthen the potential accuracy of SNP association studies in acute illness and other diseases: providing evidence of following a protocol quality control method such as the one in Nature Protocols or the OncoArray QC Guidelines; enrolling enough patients to have large cohort groups; and validating the SNPs using an independent technique such as a second study using the same SNPs with new patient cohorts. Our survey suggests the need to standardize validation methods and SNP quality control measures in medicine in general, and specifically in the context of complex disease states such as acute illness.
Transport and Dielectric Properties of Mechanosynthesized La2/3Cu3Ti4O12 Ceramics (2021)

La2/3Cu3Ti4O12 (LCTO) powder has been synthesized by the mechanochemical milling technique. The pelletized powder was conventionally sintered for 10 h at a temperature range of 975–1025 °C, which is a lower temperature process compared to the standard solid-state reaction. X-ray diffraction analysis revealed a cubic phase for the current LCTO ceramics. The grain size of the sintered ceramics was found to increase from 1.5 ± 0.5 to 2.3 ± 0.5 μm with an increase in sintering temperature from 975 to 1025 °C. The impedance results show that the grain conductivity is more than three orders of magnitude larger than the grain boundary conductivity for LCTO ceramics. All the samples showed a giant dielectric constant (1.7 × 103–3.4 × 103) and dielectric loss (0.09–0.17) at 300 K and 10 kHz. The giant dielectric constant of the current samples was attributed to the effect of internal barrier layer capacitances due to their electrically inhomogeneous structure.
Carbon nanoparticles as a multimodal thermoacoustic and photoacoustic contrast agent (2013)

We demonstrated the potential of carbon nanoparticles (CNPs) as exogenous contrast agents for both thermoacoustic (TA) tomography (TAT) and photoacoustic (PA) tomography (PAT). In comparison to deionized water, the CNPs provided a four times stronger signal in TAT at 3 GHz. In comparison to blood, The CNPs provided a much stronger signal in PAT over a broad wavelength range of 450-850 nm. Specifically, the maximum signal enhancement in PAT was 9.4 times stronger in the near-infrared window of 635-670 nm. In vivo blood-vessel PA imaging was performed non-invasively on a mouse femoral area. The images, captured after the tail vein injection of CNPs, show a gradual enhancement of the optical absorption in the vessels by up to 230%. The results indicate that CNPs can be potentially used as contrast agents for TAT and PAT to monitor the intravascular or extravascular pathways in clinical applications.
Phosphosugar Stress in Bacillus subtilis: Intracellular Accumulation of Mannose 6-Phosphate Derepressed the <i>glcR-phoC</i> Operon from Repression by GlcR (2019)

<i>Bacillus subtilis</i> phosphorylates sugars during or after their transport into the cell. Perturbation in the conversion of intracellular phosphosugars to the central carbon metabolites and accumulation of phosphosugars can impose stress on the cells. In this study, we investigated the effect of phosphosugar stress on <i>B. subtilis</i> Preliminary experiments indicated that the nonmetabolizable analogs of glucose were unable to impose stress on <i>B. subtilis</i> In contrast, deletion of <i>manA</i> encoding mannose 6-phosphate isomerase (responsible for conversion of mannose 6-phosphate to fructose 6-phosphate) resulted in growth arrest and bulged cell shape in the medium containing mannose. Besides, an operon encoding a repressor (GlcR) and a haloic acid dehalogenase (HAD)-like phosphatase (PhoC; previously YwpJ) were upregulated. Integration of the P <i><sub>glcR</sub>-lacZ</i> cassette into different mutational backgrounds indicated that P <i><sub>glcR</sub></i> is induced when (i) a <i>manA</i>-deficient strain is cultured with mannose or (ii) when <i>glcR</i> is deleted. GlcR repressed the transcription of <i>glcR-phoC</i> by binding to the σ<sup>A</sup>-type core elements of P <i><sub>glcR</sub></i> An electrophoretic mobility shift assay showed no interaction between mannose 6-phosphate (or other phosphosugars) and the GlcR-P <i><sub>glcR</sub></i> DNA complex. PhoC was an acid phosphatase mainly able to dephosphorylate glycerol 3-phosphate and ribose 5-phosphate. Mannose 6-phosphate was only weakly dephosphorylated by PhoC. Since deletion of <i>glcR</i> and <i>phoC</i> alone or in combination had no effect on the cells during phosphosugar stress, it is assumed that the derepression of <i>glcR-phoC</i> is a side effect of phosphosugar stress in <i>B. subtilis</i><b>IMPORTANCE</b><i>Bacillus subtilis</i> has different stress response systems to cope with external and internal stressors. Here, we investigated how <i>B. subtilis</i> deals with the high intracellular concentration of phosphosugars as an internal stressor. The results indicated the derepression of an operon consisting of a repressor (GlcR) and a phosphatase (PhoC). Further analysis revealed that this operon is not a phosphosugar stress response system. The substrate specificity of PhoC may indicate a connection between the <i>glcR-phoC</i> operon and pathways in which glycerol 3-phosphate and ribose 5-phosphate are utilized, such as membrane biosynthesis and teichoic acid elongation.
Single-mode polymer waveguide modulator (1991)

We report herein the first single-mode polymer waveguide modulator which can be formed on any surface regardless of its conductivity and refractive index. These include semiconductor, conductor, and insulator surfaces. The tunability of the refractive index of the polymer film allows us to shift the guiding layer from a stepped index profile to a graded index profile. The phase-matching condition for optical power transfer is achieved through current-induced index modulation. Thirty-six dB extinction ratio, which includes 3 dB absorption loss and 33 dB phase-matched cross coupling, was observed with a current injection density of ∼1.8 μA/μm2. Unlike the conventional symmetrical dual channel coupler, the disparity of the collinear waveguide pair provides us with a much larger dynamic range of waveguide dimension suitable for generating the required phase-matching condition and thus easing the requirement of waveguide fabrication.