gebhart/patrepeval huggingface dataset:
A New Member of the Mouse Prolactin (PRL)-Like Protein-C Subfamily, PRL-Like Protein-Cα: Structure and Expression**This work was supported by grants from the National Institute of Child Health and Human Development (HD-20676, HD-29797, HD-33994; to M.J.S.) and the Paul Patton Memorial Trust (to R.A.W.). (1998)

In this study, we establish the presence of a unique member of the PRL-like protein-C (PLP-C) subfamily in the mouse, PLP-C alpha, characterize its complementary DNA and gene, and map its chromosomal location and pattern of expression during pregnancy. Mouse PLP-C alpha encodes for a 239 amino acid protein and possesses from 69-71% identity with rat PLP-C, PLP-Cv, PLP-D, and PLP-H. Another feature characteristic of PLP-C subfamily members that is also present in mouse PLP-C alpha is a 6-exon/5-intron gene structure including an aromatic domain encoded by exon 3. Southern analysis with mouse and rat PLP-C subfamily probes suggested the existence of a single mouse PLP-C alpha gene. Mouse PLP-C alpha maps to chromosome 13 along with other members of the mouse PRL family. Expression of mouse PLP-C alpha increases dramatically as gestation advances and is restricted to spongiotrophoblast and trophoblast giant cells of the junctional zone. In summary, we have established the presence of a new PLP-C subfamily member in the mouse and demonstrated its similarity in structure and expression to rat PLP-C subfamily members. This level of conservation between species expands the biological significance of the PLP-C subfamily and provides additional opportunities for genetically evaluating its function.
Spatial Multiplexer and Experimental Attenuation of a Four Channel Spatial Domain Multiplexed System in Multimode Fibers Using Fiber Taper Technology (2011)

Spatial domain multiplexing (SDM) enables co-propagation of multiple spatially separated channels of same wavelength over multimode fibers. Spatial multiplexer and attenuation of four such channels over a tapered 62.5/125µm step index fiber is reported.
Creating New Electoral Public Spheres (2021)

Abstract As the dominant technology platforms have become increasingly central to political communication, they have been heavily criticized for their failure to adequately structure, monitor and moderate their public spaces. However, in many ways they conform more closely to the normative Habermasian public sphere than legacy media—notably in terms of ubiquity, accessibility, and connectivity. However, the political economy of these platforms means they cannot satisfy all the features of a democratic public sphere, and will never be sufficient. Democratic societies will therefore need to create and sustain alternative digital public spheres. One such alternative should be for elections. This chapter provides a rationale for the development of alternative public spheres and sketches out what publicly supported digital electoral public spheres might look like.
Photonic band-gap fiber gas cell fabricated using femtosecond micromachining (2007)

Femtosecond laser drilling is used to produce a variablepressure fiber gas cell. Tightly focused laser pulses are used to produce micrometer-diameter radial channels in a hollow-core photonic band-gap fiber (HC-PBGF), and through these microchannels the core of the fiber is filled with a gas. The fiber cell is formed by fusion splicing and sealing the ends of the HC-PBGF to standard step-index fiber. As a demonstration, acetylene is introduced into an evacuated fiber at multiple backing pressures and spectra are measured.
Impaired compensation to femoral artery ligation in diet-induced obese mice is primarily mediated via suppression of collateral growth by Nox2 and p47<sup>phox</sup> (2015)

The present study was undertaken to establish the role of NADPH oxidase (Nox) in impaired vascular compensation to arterial occlusion that occurs in the presence of risk factors associated with oxidative stress. Diet-induced obese (DIO) mice characterized by multiple comorbidities including diabetes and hyperlipidemia were used as a preclinical model. Arterial occlusion was induced by distal femoral artery ligation in lean and DIO mice. Proximal collateral arteries were identified as the site of major (∼70%) vascular resistance to calf perfusion by distal arterial pressures, which decreased from ∼80 to ∼30 mmHg with ligation in both lean and DIO mice. Two weeks after ligation, significant vascular compensation occurred in lean but not DIO mice as evidenced by increased perfusion (147 ± 48% vs. 49 ± 29%) and collateral diameter (151 ± 30% vs. 44 ± 17%). Vascular mRNA expression of p22(phox), Nox2, Nox4, and p47(phox) were all increased in DIO mice. Treatment of DIO mice with either apocynin or Nox2ds-tat or with whole body ablation of either Nox2 or p47(phox) ameliorated the impairment in both collateral growth and hindlimb perfusion. Multiparametric flow cytometry analysis demonstrated elevated levels of circulating monocytes in DIO mice without impaired mobilization and demargination after femoral artery ligation. These results establish collateral resistance as the major limitation to calf perfusion in this preclinical model, demonstrate than monocyte mobilization and demarginatin is not suppressed, implicate Nox2-p47(phox) interactions in the impairment of vascular compensation to arterial occlusion in DIO mice, and suggest that selective Nox component suppression/inhibition may be effective as either primary or adjuvant therapy for claudicants.
Titanium Superoxide Catalyzed Aminobromination of Olefins (2009)

A heterogeneous titanium catalyst (titanium superoxide) is prepared by treating Ti(Oi-Pr)4 with hydrogen peroxide in methanol and utilized in olefin aminobromination. The reaction follows anti-Markovnikov selectivity.
First proof-of-concept evaluation of the FUSION-X-US-II prototype for the performance of automated breast ultrasound in healthy volunteers (2020)

Purpose The FUSION-X-US-II prototype was developed to put a combination of 3D-automated breast ultrasound (ABUS) and digital breast tomosynthesis in a single device into practice. In this study, we evaluated the technical function, feasibility of the examination workflow, image quality, coverage and patient comfort of the ABUS device of the new prototype.
The miRNA Expression Profile of Experimental Autoimmune Encephalomyelitis Reveals Novel Potential Disease Biomarkers (2018)

Multiple sclerosis (MS) is a debilitating autoimmune disease affecting over 2.3 million people worldwide, and it is characterized by inflammation and demyelination of nerve cells. The currently available biomarkers for the diagnosis and management of MS have inherent limitations, therefore, additional new biomarkers are needed. We studied the microRNA (miRNA) profile of splenocytes of mice having experimental autoimmune encephalomyelitis (EAE), a model of human MS. A miRNA-microarray analysis revealed increased expression of nine miRNAs (let-7e, miR-23b, miR-31, miR-99b, miR-125a, miR-146b, miR-155, miR-193b, and miR-221) following EAE development. Interestingly, serum levels of miR-99b, miR-125a, and miR-146b were significantly higher in EAE mice compared to normal mice. Bioinformatics analysis revealed the experimentally validated as well as predicted gene targets of specific miRNAs that are important for disease progression in MS. Specifically, we observed inverse correlation in the levels of miR-99b versus <i>LIF</i>, and between miR-125a versus <i>BDNF</i> and <i>LIF</i>. Our results suggest that above-mentioned miRNAs may play a crucial role in the pathogenesis of MS, and that miR-99b, miR-125a, and miR-146b in particular may serve as useful biomarkers for disease activity.
The Development of New Microsensor Coatings and a Short Survey of Microsensor Technology (1989)

This review covers various aspects of microsensor technology with which we have been associated in our research program. Current work deals with the development of new coatings for use on surface acoustic wave (SAW) devices for both resistance and frequency-based measurements. The microsensor area is currently a small but rapidly expanding field that involves diverse disciplines, including synthetic and polymer chemistry, analytical chemistry, surface science, computer science, and electronic engineering. We have attempted to assist the reader by describing various other facets while highlighting the development of new microsensor coatings. These facets include the way in which the synthetic chemistry is guided by requirements of coating technology and surface science and notes on the use of sophisticated electronic devices and data manipulation techniques to evaluate the compounds synthesized.
Design study for transmission improvement of resonant surface plasmons using dielectric diffraction gratings (2009)

A transmission-type surface plasmon resonance configuration with dielectric gratings regularly patterned on a silver film was investigated with the aim of enhancing the diffraction efficiency of radiative surface plasmons. The theoretical work was conducted using rigorous coupled-wave analysis in terms of first order diffraction efficiency and conversion efficiency (CE). The results show that pyramid gratings can produce a higher transmittance compared with other grating profiles. Design optimization of the pyramid grating at a wide range of grating thicknesses and periods resulted in a maximum transmittance that was larger than 77% and a peak CE of about 85%. This study demonstrates the potential of using transmitted surface plasmon waves in various optical devices, such as optical biosensors, optical imaging systems, and polarization filters.
Post-characteristics of Formed Zn-22 mass%Al Alloy to Seismic Damper for General Residence (2009)

It has been reported that superplastic Zn-22 mass%Al alloy has some excellent properties needed for seismic damping devices. In addition, seismic damping devices using this alloy has already been put into practical use for a high-rise building. In the present investigation, we tried to apply this alloy to seismic damping devices for a general residence and examined the formability and the characteristics after the formation. No cracks were observed in the sample formed even at room temperature. The surface roughness, R a , was improved from 0.602μm before the formation to 0.418 μm after the formation. As the results of FVM analysis, it was predicted that the formed sample could exhibit the higher stress and strain at both sides of the inferior part of the gauge section. However, the average grain size, the ratio of the major axis length to minor axis one in a grain, and the hardness in the region exhibiting high stress and strain were almost the same characteristics as those in the initial sample.
Cadmium and High-Fat Diet Disrupt Renal, Cardiac and Hepatic Essential Metals (2019)

Exposure to the environmental toxicant cadmium (Cd) contributes to the development of obesity-associated diseases. Obesity is a risk factor for a spectrum of unhealthy conditions including systemic metabolic dyshomeostasis. In the present study, the effects of whole-life exposure to environmentally-relevant concentrations of Cd on systemic essential metal distribution in adult mice fed a high-fat diet (HFD) were examined. For these studies, male and female mice were exposed to Cd-containing drinking water for >2 weeks before breeding. Pregnant mice and dams with offspring were exposed to Cd-containing drinking water. After weaning, offspring were continuously exposed to the same Cd concentration as their parents, and divided into HFD and normal (low) fat diet (LFD) groups. At 10 and 24 weeks, mice were sacrificed and blood, liver, kidney and heart harvested for metal analyses. There were significant concentration dependent increases in Cd levels in offspring with kidney > liver > heart. Sex significantly affected Cd levels in kidney and liver, with female animals accumulating more metal than males. Mice fed the HFD showed > 2-fold increase in Cd levels in the three organs compared to similarly treated LFD mice. Cadmium significantly affected essential metals levels in blood, kidney and liver. Additionally, HFD affected essential metal levels in these three organs. These findings suggest that Cd interacts with HFD to affect essential metal homeostasis, a phenomenon that may contribute to the underlying mechanism responsible for the development of obesity-associated pathologies.
Surface Degradation Mechanism During the Fluorine-Based Plasma Etching of a Low-&lt;I&gt;k&lt;/I&gt; Material for Nanoscale Semiconductors (2014)

The degradation of a low-k material surface during the exposure to plasma etching is one of the most serious problems to be solved for the realization of high speed semiconductor devices. In this study, the factors causing the degradation of a low-k material surface during the etching using fluorine-based plasma etching have been investigated by using XPS. As the plasma factors, active radicals, bombardment energy, and charge of the ions were considered and, as the low-k material, methyl silsesquioxane (MSQ) has been used. The XPS results showed that the ion bombardment during the plasma etching of MSQ affects the breaking of MSQ bone structure by changing the Si-O bonds and Si-C bonds to Si-F mostly, while fluorine-based radicals in the plasma mostly affect the change of Si-CH3 bonds to Si-CH(x)F(y). By removing the charge of the ions during the bombardment, the MSQ properties were further improved. When F intensity which is related to the damage of the MSQ surface is estimated, the bombardment energy, reactive radical density, and charge of the ions were responsible for -18%, -53%, -19% of the F intensity in the MSQ. Therefore, by using the neutral beam etching instead of a conventional ICP etching, the degradation on the MSQ surface estimated by the F intensity remaining on the MSQ surface could be decreased to 10%.
Preparative‐scale, recirculating, pH‐biased binary isoelectric trapping separations (2004)

In order to improve the production rates and lower the specific electrophoretic energy consumption values in preparative-scale, recirculating, binary isoelectric trapping separations, we propose to add an auxiliary isoelectric agent to the solution in the anodic separation compartment and another to the solution in the cathodic separation compartment to implement pH-biased isoelectric trapping. The auxiliary isoelectric agents are selected such that they are trapped in the respective anodic and cathodic separation compartments and also, have isoelectric point (pI) values that are different from the pI values of the analytes of interest. By proper selection of the auxiliary isoelectric agents and their concentrations, the analytes of interest can be kept in nonisoelectric, charged state during the entire course of the preparative-scale, recirculating, binary isoelectric trapping separation. This results in higher electrophoretic mobilities and solubilities for the analytes than in their isoelectric or near-isoelectric states, and leads to faster binary isoelectric trapping separations.
Production of A Single Chain Anti-CEA Antibody From the Hybridoma Cell Line T84.66 Using a Modified Colony-Lift Selection Procedure to Detect Antigen-Positive ScFv Bacterial Clones (1998)

Recombinant single chain Fv (scFv) antibodies offer many advantages over mouse monoclonal antibodies (MAbs) such as faster clearance from blood, improved tumor localization, reduced human anti-mouse antibody (HAMA) response, and the availability to manipulate the scFv through genetic approaches. The scFv antibody (designated RK10.2) was generated using anti-CEA T84.66 hybridoma cells as a source of genetic starting material and the Pharmacia Recombinant Phage Antibody System (RPAS). Escherichia coli clones expressing antigen-positive soluble scFv were identified using a modified colony-life selection procedure and antigen-coated filters. The resultant anti-CEA scFv (designated RK10.2) had a molecular weight of approximately 33.6 kDa and an isoelectric point of 5.2 at 15 degrees C. The RK10.2 scFv interacted with LS174 T cells bearing the CEA antigen and inhibited the anti-CEA MAb/CEA antigen interaction in ELISA and the anti-CEA MAb/LS174 T cell interaction in a RIA. The modified colony-lift approach circumvented the more time-consuming phage-display approach that is normally taken to affinity select for antigen-positive scFv clones.
Picosecond Fiber MOPA Pumped Supercontinuum Source With 39 W Output Power (2010)

We report picosecond fiber MOPA pumped supercontinuum source with 39W output, spanning at least 0.4-1.75µm with high and relatively uniform spectral power density of ~31.7mW/nm corresponding to peak power density of ~12.5W/nm in 20ps pulse.
The rabbit as an orthologous small animal model for APOBEC3A oncogenesis (2018)

APOBEC3 are cytidine deaminases that convert cytidine to uridine residues. APOBEC3A and APOBEC3B enzymes able to target genomic DNA are involved in oncogenesis of a sizeable proportion of human cancers. While the <i>APOBEC3</i> locus is conserved in mammals, it encodes from 1-7 genes. <i>APOBEC3A</i> is conserved in most mammals, although absent in pigs, cats and throughout <i>Rodentia</i> whereas <i>APOBEC3B</i> is restricted to the <i>Primate</i> order. Here we show that the rabbit <i>APOBEC3</i> locus encodes two genes of which <i>APOBEC3A</i> enzyme is strictly orthologous to human APOBEC3A. The rabbit enzyme is expressed in the nucleus and the cytoplasm, it can deaminate cytidine, 5-methcytidine residues, nuclear DNA and induce double-strand DNA breaks. The rabbit APOBEC3A enzyme is negatively regulated by the rabbit TRIB3 pseudokinase protein which is guardian of genome integrity, just like its human counterpart. This indicates that the APOBEC3A/TRIB3 pair is conserved over approximately 100 million years. The rabbit <i>APOBEC3A</i> gene is widely expressed in rabbit tissues, unlike human <i>APOBEC3A</i>. These data demonstrate that rabbit could be used as a small animal model for studying APOBEC3 driven oncogenesis.
Cost-effective streaming server implementation using Hi-tactix (2002)

High performance and high quality for continuous media stream delivery needed by streaming server systems cannot be achieved efficiently using general-purpose operating systems, due to the overhead of the I/O mechanism implementation generally used. Special OS combined with powerful hardware can deliver better performance and quality but increases development complexity and deployment costs. The External I/O Engine Architecture adopts a hybrid approach, implementing streaming engines using the streaming-oriented Hi-Tactix operating system on inexpensive hardware, in combination with existing stream servers. The evaluation results of a QuickTime video server implemented with the existing Darwin Streaming Server using the External I/O Engine Architecture shows that Hi-Tactix can deliver 5 times the performance of a conventional OS and better stream quality, while keeping the amount of code necessary low.
Soluble vascular cell adhesion molecule 1 mediation of monocyte chemotaxis in rheumatoid arthritis (2000)

These results demonstrate a novel function for sVCAM-1 as a monocyte chemotactic agent in RA and suggest a new potential target for modulating monocyte ingress into inflamed RA ST.
The EMC AVIATORS Club meets in Dresden (2015)

During the 2015 IEEE EMC Symposium in Dresden, Germany, the EMC AVIATORS Club met again. Thanks to the planning efforts of Andy Marvin (from the University of York, United Kingdom) and Peter Muller (from Technische Universitat Dresden, Germany) they were able to meet along with Antonio Orlandi (from the University of L'Aquila, Italy) at the Dresden International Conference Center on Tuesday, August 18, and organize a flight event the day after at the airfield of Mohorn.
K‐<i>ras</i> point mutations in human colorectal carcinomas: Relation to aneuploidy and metastasis (1992)

Material from paraffin sections of 109 human colorectal carcinomas, mostly obtained at autopsy, was analyzed for the presence of K-ras point mutations at codon 12, position 2. Mutations at this position were found in 23 cases (21.1%). Aneuploid colorectal carcinomas showed a significantly higher prevalence of K-ras point mutations than diploid tumors, suggesting an involvement of ras mutations in the development of aneuploidy. No differences in the prevalence of K-ras mutations were observed with respect to the patients' age, sex and tumor type. In metastases, the type of ras gene mutation was always identical to that of the respective primary tumor. Mutations were not found in metastases from primary tumors devoid of ras mutations. This renders a clonal selection of K-ras mutated cells from a wild-type primary tumor during the metastatic process unlikely. However, nearly twice as many ras gene mutations were seen in metastatic than in non-metastatic primary tumors.
Field Screening for Onion White Rot Resistance (1998)

Onion white rot disease ( Sclerotium cepivorum ) is a serious production problem throughout the world. Very low pathogen level in the soil can cause significant loss. Generic integrated pest management programs include clean seed, site selection, sanitation, crop rotation, biological and chemical controls, crop resistance to the pest, and other components. Onion white rot disease management currently does not have crop resistance as a component. The lack of resistant germplasm and/or the inability to identify and screen potentially resistant germplasm are primary reasons. Research was conducted to determine if field screening for resistance is feasible, to define field screening methodology, and to identify and/or quantify resistance. Disease incidence was inconsistent from year to year. In some years, disease expression was high; in others, disease was low. Uniform pathogen level and disease expression throughout the experimental field were required for successful screening. Results provide evidence that “resistant” or “tolerant” germplasm does exist, and that disease “resistance”, “tolerance”, or “susceptibility” can vary from slight to strong, suggesting multigenic involvement. “Resistance”/”tolerance” was identified in long-day yellow hybrids and inbreds. `Southport White Globe' selections and derivatives had much higher disease susceptibility than yellow or brown skin lines screened.
Synchronization of Diffusively Coupled Electronic Hindmarsh-Rose Oscillators (2010)

In this chapter we present results on synchronization of diffusively coupled Hindmarsh-Rose (HR) electronic oscillators. These electronic oscillators are analog electrical circuits which integrate the differential equations of the Hindmarsh-Rose model. An experimental setup consisting of four chaotic Hindmarsh-Rose oscillators, is used to evaluate the existence and stability of partially or fully synchronized states.
Tuning the optical performance of surface quantum dots in InGaAs/GaAs hybrid structures (2007)

GaAs spacer thicknesses are varied to tune the coupling between InGaAs surface quantum dots (QDs) and multilayers of buried QDs. Temperature and excitation intensity dependence of the photoluminescence together with time resolved photoluminescence reveal that coupling between layers of QDs and consequently the optical properties of both the surface and the buried QDs significantly depend on the GaAs spacer. This work provides an experimental method to tune and control the optical performance of surface QDs.