gebhart/patrepeval huggingface dataset:
Auditory localization in the near-field (1996)

Presented at 3rd International Conference on Auditory Display (ICAD), Palo Alto, California, November 4-6, 1996.
Enhancing curcumin's solubility and antibiofilm activity<i>via</i>silica surface modification (2020)

Bacterial biofilms are microbial communities in which bacterial cells in sessile state are mechanically and chemically protected against foreign agents, thus enhancing antibiotic resistance. The delivery of active compounds to the inside of biofilms is often hindered due to the existence of the biofilm extracellular polymeric substances (EPS) and to the poor solubility of drugs and antibiotics. A possible strategy to overcome the EPS barrier is the incorporation of antimicrobial agents into a nanocarrier, able to penetrate the matrix and deliver the active substance to the cells. Here, we report the synthesis of antimicrobial curcumin-conjugated silica nanoparticles (curc-NPs) as a possibility for dealing with these issues. Curcumin is a known antimicrobial agent and to overcome its low solubility in water it was grafted onto the surface of silica nanoparticles, the latter functioning as nanocarrier for curcumin into the biofilm. Curc-NPs were able to impede the formation of model <i>P. putida</i> biofilms up to 50% and disrupt mature biofilms up to 54% at 2.5 mg mL<sup>-1</sup>. Cell viability of sessile cells in both cases was also considerably affected, which is not observed for curcumin delivered as a free compound at the same concentration. Furthermore, proteomics of extracted EPS matrix of biofilms grown in the presence of free curcumin and curc-NPs revealed differences in the expression of key proteins related to cell detoxification and energy production. Therefore, curc-NPs are presented here as an alternative for curcumin delivery that can be exploited not only to other bacterial strains but also to further biological applications.
ChemInform Abstract: Cobalt(II) Bis(1,4,7‐trithiacyclononane): A Low‐Spin Octahedral Complex. (1987)

Abstract Cobalt(II) forms a cationic 1:2 complex with 1,4,7‐trithiacyclononane with an unprecedentedly large overall formation constant.
A New Frequency-Adaptive Phase-Estimation Method Based on a New PLL Structure for Single-Phase Signals (2007)

Phase, frequency, and amplitude of single-phase voltages are the most important and basic information required for single-phase grid connected applications. This paper proposes a new method for estimating instantly and adaptively phase, frequency, and amplitude of frequency-varying single-phase signals for such applications, which is a new PLL method based on a new structure. The proposed method has the following attractive features: 1) the estimation system results in a nonlinear system, but it can be stabilized; 2) all subsystems constructing the system can be easily designed; 3) two-phase signal generator can tune a single system-parameter adaptively to varying frequency of the injected signal; 4) high order PLL-controllers allowing fast tracking can be stably used; 5) even in hostile envelopments, favorable instant estimates can be obtained. This paper proposes the estimation method, and verifies its usefulness by extensive numerical experiments.
Point matching as a classification problem for fast and robust object pose estimation (2004)

We propose a novel approach to point matching under large viewpoint and illumination changes that are suitable for accurate object pose estimation at a much lower computational cost than state-of-the-art methods. Most of these methods rely either on using ad hoc local descriptors or on estimating local affine deformations. By contrast, we treat wide baseline matching of key points as a classification problem, in which each class corresponds to the set of all possible views of such a point. Given one or more images of a target object, we train the system by synthesizing a large number of views of individual key points and by using statistical classification tools to produce a compact description of this view set. At run-time, we rely on this description to decide to which class, if any, an observed feature belongs. This formulation allows us to use a classification method to reduce matching error rates, and to move some of the computational burden from matching to training, which can be performed beforehand. In the context of pose estimation, we present experimental results for both planar and non-planar objects in the presence of occlusions, illumination changes, and cluttered backgrounds. We show that the method is both reliable and suitable for initializing real-time applications.
Determining local residual strains of polydimethylsiloxane using ink dots, and stiffening polydimethylsiloxane using SU-8 particles (2002)

We have developed two methods to characterize and reduce the deformation of polydimethylsiloxane (PDMS) during its planar molding process. The first method was to determine the local residual strain of PDMS using ink dots. The information of the local residual strain was used to optimize the processing. The second method was to increase the stiffness of PDMS using SU-8 particles. The two methods were applied to a PDMS planar process. With the aid of the methods, the maximum local strain in the released PDMS has been reduced to meet the requirement of misalignment tolerance.
Oxide cathodes for electrochemical devices made with the use of a nanostructured composition material (2012)

The possibility of using the LnO x mischmetal (Ln = Ce, La, Nd, Pr, Sm) for preparation of cathodes for solid-oxide fuel cells with the supported YSZ electrolyte is studied. The electrical and electrochemical characteristics of Ln-Mn-O electrodes with the ratio of all lanthanides contained in the mischmetal except for cerium to manganese Ln: Mn = 1: 1 and also of a material comprised of Ln-Mn-O and La0.8Sr0.2MnO3 are studied. The latter electrode material that contains 35–40 wt % of Ln-Mn-O and was sintered at 1200°C has the specific ohmic resistance of 0.1 Ω cm at 800°C. The polarization conductivity is compared for electrodes made of 100% Ln-Mn-O, 40 wt % Ln-Mn-O + 60 wt % La0.8Sr0.2MnO3, and 100% La0.8Sr0.2MnO3 in the initial state and after their modification through the introduction of an electrocatalyst (PrO2 − x ). The highest polarization conductivity is typical of Ln-Mn-O + (La, Sr)MnO3 electrodes containing 40 wt % Ln-Mn-O and PrO2 − x . The polarization conductivity of these electrodes is found to be 25 S/cm2 at 800°C.
Integrating User and Usage Information in a Design Environment (2014)

We describe research exploring and demonstrating the use of large-scale data gathering and processing to inform the activities of architectural and urban designers. We apply this research to public spaces in urban housing estates. The aim is to understand the current use patterns and usability of these spaces, and to adaptively redesign them according to the insights gained from these findings. Another aim of the research is to obtain scientific knowledge regarding the production and use of user-data-based design support systems which promote and enhance the capability of (digital) design aids, such as building- and urban-scale models, to act as Âlearning devicesÂ giving designers better insights to the nature of the design situations they are asked to address, as well as insights on design space definition and exploration. We adopt a multimodal data collection strategy, consisting of participatory workshops for residents and users, person-based crowdsourcing, location-based crowd sensing, and statistical demographics data.
Adaptionsbarrieren im Technologietransfer - Begriff, Relevanz und Implikationen für das Marketing (2013)

Der Erfolg eines Technologietransfers hängt unter anderem von der Bereitschaft und Fähigkeit potenzieller Anwender zur Akzeptanz der zu transferierenden Technologie ab. Während die Literatur dem Prozess des Technologietransfers große Aufmerksamkeit widmet, gibt es vergleichsweise wenige Erkenntnisse zum Management von Akzeptanzbarrieren und Kommunikationsmaßnahmen zur Bewältigung dieser Barrieren. Ziel des vorliegenden Beitrags ist es, diese Barrieren näher zu untersuchen und Kommunikationsinhalte und -instrumente zu betrachten, die diese Barrieren wirkungsvoll überwinden helfen. Der vorliegende Beitrag diskutiert daher den Stand der Literatur zur Adaption von Innovationen und zur Förderung einer Innovationsadaption durch Kommunikationsinhalte und -instrumente. Am Beispiel einer neuartigen Fügetechnologie werden Maßnahmen für eine zielgerichtete Vermittlung von Informationen zur Förderung ihrer Adaption durch potenzielle Anwender dargestellt. Der Beitrag endet mit einer Zusammenfassung und einem Ausblick auf weitere Forschungsfragen.
The effects of liquid-CO2 cooling, MQL and cutting parameters on drilling performance (2021)

An investigation is made into the effects of liquid carbon dioxide (LCO2) cooling, minimum-quantity lubrication (MQL) and cutting speed in drilling. Experimental measurements of torque, thrust force and temperature are made over a wide range of process and operating conditions. The resulting empirical models are used to quantify the individual contributions of the controlled parameters on drilling performance, and to facilitate temperature-based process optimization. Of particular interest is the need to carefully adjust the LCO2 flow rate for any combination of MQL flow rate and cutting speed. The optimization is validated both in simulation and actual drilling tests.
Leader properties determined with triggered lightning techniques (1998)

This paper presents current and electric field measurements from two triggered lightning flashes, 9519 and 9516, initiated by the “classical” and “altitude” technique, respectively, at Camp Blanding, Florida, in 1995. The current measurement for flash 9519 shows that the upward positive leader, initiated at the top of the grounded wire unreeled by the triggering rocket, propagates in a discontinuous pattern made of successive current pulses of tens to a few hundreds of amperes and separated by intervals of 20–25 μs. The downward negative leader in flash 9516, initiated from the electrically floating conductor, has a velocity greater than 1.3×10 5 m s −1 , a stepping interval of 18 μs, and step length of about 3–5 m; the associated peak currents inferred from the electric field steps are at least 600 A.
Cell activation by Toll-like receptors: role of LBP and CD14 (2004)

Members of the Toll-like receptor (TLR) family have been shown to be important in the activation of cells by a variety of microbial ligands. TLRs are thought to mediate the 'recognition event' that follows an encounter between a mammalian cell and a microbial agent. In the case of the response to bacterial lipopolysaccharide (LPS), it is clear that the ability of these cell surface proteins to initiate the events necessary for activation of cells to produce cytokines is dependent upon 'accessory proteins' such as the pattern recognition protein CD14 and the lipopolysaccharide binding protein (LBP). While the role of these proteins in the LPS-specific response is defined, their role in other TLR responses has not been defined, but it is important in understanding these events and, potentially, in designing new therapeutic strategies. Here we report on the role of these proteins in the response to yeast zymosan. The requirements for this response (which unlike the response to LPS is a response to a particulate antigen) and the role of other serum proteins are defined.
Peptidkonformationen, 36 Konformationsuntersuchungen an vier cyclischen Heptapeptiden durch NMR‐Spektroskopie (1985)

Abstract Die Synthese und Konformationsanalyse der vier cyclischen Heptapeptide cyclo [‐Ala‐Ile‐Val‐Ser‐(Bzl)‐Xxx‐Phe‐Gly‐] ( 1 : Xxx=Pro, 2 : Xxx  Aib), cyclo [‐Gly‐Phe‐Leu‐Ala‐Lys(Z)‐Tyr(Bzl)‐Gly‐] ( 3 ) und cyclo [‐D‐Trp‐Lys(Z)‐Thr‐Val‐Pro‐Gly‐Phe‐] ( 4 ) durch 1 H‐, 13 C‐ und zum Teil 15 N‐NMR‐Untersuchungen werden beschrieben. 3 enthält die Sequenz des Leu‐Enkephalins, während 4 die aktive Sequenz des Somatostatins (Phe 6 ‐Thr 10 ) enthält. Die nach Abspaltung der Schutzgruppen von 3 und 4 getesteten Verbindungen wiesen keine biologische Aktivität auf. Die Zuordnung der Spektren erfolgte durch homo‐ und heteronuklear korrelierte 2D‐NMR‐Techniken. 2 und 3 weisen nur trans ‐Peptidbindungen auf, die Ser – Pro‐Bindung in 1 ist cis ‐konfiguriert. Aus den Temperaturabhängigkeiten der NH‐Signale, den Kopplungskonstanten und den NOE‐Effekten wird für 1 und 2 eine im Bereich von Gly‐Ala‐Ile‐Val β‐Faltblatt‐ähnliche Struktur abgeleitet. Die Glycin‐Carbonylgruppe fungiert dabei als Akzeptor für Wasserstoffbrücken von zwei NH‐Gruppen (Ile, Val). Im Bereich Ser‐Xxx‐Phe unterscheiden sich beide Konformationen erheblich, der Einbau von Aib (in 2 ) anstelle von Pro (in 1 ) führt zum Wegfall der in 1 auftretenden βVI‐Schleife Val‐C  O ← H – N‐Phe. Cyclus 3 besitzt eine ungewöhnlich scharfe Differenzierung der Amid‐NH‐Temperaturgradienten, welche auf ein hohes Maß an Rigidität des Gerüsts deutet. Nachgewiesen werden konnten eine β‐Faltblatt‐ähnliche Struktur sowie eine γ i ‐Schleife Ala‐C  O ← H – N‐Tyr. Das Cyclopeptid 4 ist konformationell nicht einheitlich.
Nanomaterials for Neural Interfaces (2009)

This review focuses on the application of nanomaterials for neural interfacing.\nThe junction between nanotechnology and neural tissues can be particularly worthy of scientific attention for several reasons: (i) Neural cells are electroactive, and the electronic properties of nanostructures can be tailored to match the charge transport requirements of electrical cellular interfacing. (ii) The unique mechanical and chemical properties of nanomaterials are critical for integration with neural tissue as long-term implants. (iii) Solutions to many critical problems in neural biology/medicine are limited by the availability of specialized materials. (iv) Neuronal stimulation is needed for a variety of common and severe health problems.
Individual-based network model for Rift Valley fever in Kabale District, Uganda (2019)

Rift Valley fever (RVF) is a zoonotic disease, that causes significant morbidity and mortality among ungulate livestock and humans in endemic regions. In East Africa, the causative agent of the disease is Rift Valley fever virus (RVFV) which is primarily transmitted by multiple mosquito species in Aedes and Mansonia genera during both epizootic and enzootic periods in a complex transmission cycle largely driven by environmental and climatic factors. However, recent RVFV activity in Uganda demonstrated the capability of the virus to spread into new regions through livestock movements, and underscored the need to develop effective mitigation strategies to reduce transmission and prevent spread among cattle populations. We simulated RVFV transmission among cows in 22 different locations of the Kabale District in Uganda using real world livestock data in a network-based model. This model considered livestock as a spatially explicit factor in different locations subjected to specific vector and environmental factors, and was configured to investigate and quantitatively evaluate the relative impacts of mosquito control, livestock movement, and diversity in cattle populations on the spread of the RVF epizootic. We concluded that cattle movement should be restricted for periods of high mosquito abundance to control epizootic spreading among locations during an RVF outbreak. Importantly, simulation results also showed that cattle populations with heterogeneous genetic diversity as crossbreeds were less susceptible to infection compared to homogenous cattle populations.
Yin-Yang Puzzles are NP-complete. (2021)

We prove NP-completeness of Yin-Yang / Shiromaru-Kuromaru pencil-and-paper puzzles. Viewed as a graph partitioning problem, we prove NP-completeness of partitioning a rectangular grid graph into two induced trees (normal Yin-Yang), or into two induced connected subgraphs (Yin-Yang without $2 \times 2$ rule), subject to some vertices being pre-assigned to a specific tree/subgraph.
Memristors as non-linear behavioral models for passive inter-modulation simulation (2014)

We propose to use memristors as memory nonlinear circuits to build behavioral models useful in the simulation of passive inter-modulation in RF and microwave devices such as filters, antennas and in general connections.
Tree structured non-linear signal modeling and prediction (2002)

We develop a non-parametric method of nonlinear prediction based on adaptive partitioning of the phase space associated with the process. The partitioning method is implemented with a recursive tree-structured vector quantization algorithm which successively refines the partition by binary splitting where the splitting threshold is determined by a penalized maximum entropy criterion. A complexity penalty is derived and applied to protect against high statistical variability of the predictor structure. We establish an important relation between our tree-structured model for the process and generalized non-linear thresholded AR model (ART). We illustrate our method for two cases where classical linear prediction is ineffective: a chaotic "double-scroll" signal measured at the output of a Chua-type electronic circuit, and a simulated second order ART model.
DNA-cellulose: an economical, fully recyclable and highly effective chiral biomaterial for asymmetric catalysis (2015)

The challenge in DNA-based asymmetric catalysis is to perform a reaction in the vicinity of the helix by incorporating a small-molecule catalyst anchored to the DNA in a covalent, dative, or non-covalent yet stable fashion in order to ensure high levels of enantio-discrimination. Here, we report the first generation of a DNA-based catalyst bound to a cellulose matrix. The chiral biomaterial is commercially available, trivial to use, fully recyclable and produces high levels of enantioselectivity in various Cu(II)-catalyzed asymmetric reactions including Friedel-Crafts alkylations and Michael additions. A single-pass, continuous-flow process is also reported affording fast conversions and high enantioselectivities at low catalyst loadings thus offering a new benchmark in the field of DNA-based asymmetric catalysis.
Entwicklung und experimentelle Testung eines Extraktionssystems für pulmonale Emboli (2004)

Ziele: Die Entwicklung eines einfach handhabbaren, schnell platzierbaren und pulmonal ausreichend steuerbaren Instruments, das eine effektive Rekanalisation bei ausgedehnter Embolisierung der arteriellen Lungenstrombahn erlaubt. Methode: Es wurde zunächst das Grundprinzip verfolgt, das Instrument aus zwei entfaltbaren koaxialen Körben zusammenzusetzen: Extraktionskorb und Fangkorb. In einem weiteren Labormuster wurde zur Vereinfachung der Handhabung der Trägerkatheter mit einem Fangkorb versehen, der über den Emboluskopf gestülpt werden kann. Der entfaltbare Korb ist kunststoffbeschichtet, so dass das Embolusmaterial angesaugt, fragmentiert und über einen Arbeitskanal extrahiert werden kann. Über einen Y-Adapter am Katheterende ist eine manuell betätigbare Knopfsonde in den Arbeitskanal eingebaut. Vergleichende Funktionstests verschiedener Versionen und Kombinationen daraus wurden im statischen pulmonalen Glasmodell durchgeführt, gefolgt von Positionierungs- und Funktionstests im dynamischen Kreislaufmodell. Ergebnis: Bereits in den in-vitro-Tests zeigte sich, dass das Zusammenspiel zweier koaxial zusammengesetzter Körbe von der Handhabung her zu komplex ist und zu viele Fehlermöglichkeiten impliziert. Die Testung der Saugkorbversion ergab, dass teilorganisiertes Embolusmaterial im Ansaugloch des Korbtrichters mittels Knopfsonde entfernt werden kann. In ersten Tierversuchen konnte das System über einen jugulären oder femoralen Zugang positioniert und ein Teil der Emboli entfernt werden. Einschränkungen ergaben sich durch die mangelnde Beweglichkeit des Korbes auf der Katheterspitze. Schlussfolgerung: Die perkutane, transkatheterale Extraktion pulmonaler Emboli durch einen entfaltbaren, beschichteten Saugkorb ist möglich. Die Effizienz des Verfahrens ist derzeit noch durch eine eingeschränkte Manövrierbarkeit des Systems limitiert. In einer Folgeversion soll dies durch weitere Material- und Designverbesserungen gelöst werden.
Pneumatica e logistica (1994)

Sono analizzati i problemi dell'uso di dispositivi pneumatici nella logistica. Comparso su: BLU SMC n. 9-10, dicembre 1994-gennaio 1995
Dietary impact of a plant-derived microRNA on the gut microbiome (2020)

A mouse diet composed of a transgenic plant expressing a mouse miR-146a may fine tune microbial communities but does not appear to have global effects on microbiome structure and composition.
Terahertz Sources and Receivers: From the past to the Future (2023)

&lt;p&gt;The paper gives an overview of Semiconductor-based THz sources and receivers.&lt;/p&gt;
ChemInform Abstract: Bimetallic Catalysts for Upgrading of Biomass to Fuels and Chemicals (2013)

Abstract Review: 236 refs.
The interaction of <i>APOE</i> genotype and amyloid‐β PET predicts PET but not CSF measures of tauopathy in regions of high <i>APOE</i> mRNA expression (2021)

Abstract Background The apolipoprotein E ( APOE ) ε4 allele is the most well‐established genetic risk factor for late‐onset Alzheimer disease (AD). The ε4 allele is strongly linked with cerebral β‐amyloidosis whereas its relationship with tauopathy is less established. Here we investigate the relationship between APOE ε4 carrier status, regional amyloid‐β‐ (Aβ) and tau‐ positron emission topography (PET), APOE mRNA expression patterns, and cerebrospinal fluid phosphorylated tau (CSF ptau). Method 350 participants from the Knight Alzheimer Disease Research Center (mean age = 69.7) underwent tau‐PET ([ 18 F]‐flortaucipir) and Aβ‐PET ([ 18 F]‐florbetapir) imaging. Tau‐ and Aβ‐ PET data were converted to standardized uptake value ratios (SUVRs). APOE ε4 carrier status was defined by the presence of at least one ε4 allele. CSF ptau data was available for 270 of the participants. Linear regression models were used to predict regional Aβ‐ and tau‐PET levels from APOE ε4 carrier status. Additional models were used to predict regional tau‐PET and CSF ptau from the interaction of APOE genotype and global Aβ‐PET. Age and sex were included as covariates in all models. Regional APOE mRNA expression was derived from the Allen Human Brain Atlas (Fig. 3G). Result Strong associations were found between elevated regional tau‐ and Aβ‐ PET levels and APOE ε4 carrier status (Fig. 1A, B). There was a significant interaction between APOE genotype and global Aβ‐PET predicting tau‐PET levels specifically in the entorhinal, amygdala, and superior temporal regions (Fig 1C), but not CSF ptau (Fig. 2). The spatial pattern of APOE mRNA expression was significantly associated to the spatial pattern of APOE ε4 genotype exerted on regional tau‐PET, but less so for regional Aβ‐PET (Fig. 3). Conclusion APOE ε4 genotype exerts influence on tauopathy above its effect on Aβ. These effects occur in regions of the brain that have high APOE mRNA expression, suggesting potential local tissue vulnerability to tauopathy. The lack of an interaction in CSF ptau may be due to different roles soluble and aggregated forms of the tau protein play in AD pathophysiology.