gebhart/patrepeval huggingface dataset:
Morphology of blends of .alpha.,.omega.-diaminopolystyrene with .alpha.,.omega.-dicarboxypoly(ethylene oxide) (1993)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMorphology of blends of .alpha.,.omega.-diaminopolystyrene with .alpha.,.omega.-dicarboxypoly(ethylene oxide)Katsuhiko Iwasaki, Akira Hirao, and Seiichi NakahamaCite this: Macromolecules 1993, 26, 8, 2126–2131Publication Date (Print):April 1, 1993Publication History Published online1 May 2002Published inissue 1 April 1993https://pubs.acs.org/doi/10.1021/ma00060a048https://doi.org/10.1021/ma00060a048research-articleACS PublicationsRequest reuse permissionsArticle Views200Altmetric-Citations33LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
Poly(oxanorbornene)-Coated CdTe Quantum Dots as Antibacterial Agents (2020)

In this study, synthetic mimics of antimicrobial peptides based on poly(oxanorbornene) molecules (or PONs) were used to coat CdTe quantum dots (QDs). These PONs-CdTe QDs were investigated for their activity against <i>Escherichia coli</i>, a bacterium with antibiotic resistant strains. At the same time, the antibacterial activity of the PONs-CdTe QDs was compared to the antibacterial activity of free PONs and free CdTe QDs. The observed antibacterial activity of the PONs-CdTe QDs was additive and concentration dependent. The conjugates had a significantly lower minimum inhibitory concentration (MIC) than the free PONs and QDs, particularly for PONs-CdTe QDs which contained PONs of high amine density. The maximum activity of PONs-CdTe QDs was not realized by conjugating PONs with the highest intrinsic antibacterial activity (i.e., the lowest MIC in solution as free PONs), indicating that the mechanism of action for free PONs and PONs-CdTe QDs is different. Equally important, conjugating PONs to CdTe QDs decreased their hemolytic activity against red blood cells compared to free PONs, lending to higher therapeutic indices against <i>E. coli</i>. This could potentially enable the use of higher, and therefore more effective, PONs-QDs concentrations when addressing bacterial contamination, without concerns of adverse impacts on mammalian cells and organisms.
Multicenter Laboratory Comparison of Iohexol Measurement (2018)

For 12 URMC calibrator lots from 11/ 2006 to 3/ 2016, the factor quantifying the underestimation of measured to true iohexol concentration was 0.89. If each concentration were divided by 0.89, the calculated GFRs would be reduced by 10-11%. GFR results for CKiD were adjusted for this shift in calibration. Regular examination of iohexol proficiency testing materials, free exchange of samples among laboratories, and standardized dilution of the stock iohexol for calibration would help to bring more universal agreement to this assay.
Stepwise Reduction of an α‐Phosphonio–Carbocation to a Crystalline Phosphorus Radical Cation and an Acridinyl–Phosphorus Ylide (2015)

We have synthesized the dicationic α-phosphonio-carbocation 1(2+) , which can be regarded as a two-electron oxidized phosphorus ylide. Carbocation 1(2+) exhibits two reversible reduction waves at -0.28 and -0.90 V (vs. Fc(+) /Fc) indicating that both the radical cation 1(.+) and the neural phosphorus ylide 1 can be generated. Indeed, reduction of 1(2+) with Zn afforded 1(.+) as a dark green solid that was characterized by XRD and EPR spectroscopy, and reduction with Mg(Ant)⋅(THF)3 gave 1, which was characterized by (1) H and (31) P NMR spectroscopy. Computational analyses reveal the stepwise population of a C-P π bonding orbital upon reduction of 1(2+) .
C-Reactive Protein in the Prediction of Localization of Gastrointestinal Perforation (2019)

Increased CRP levels predict worse clinical outcome in patients with intra-abdominal hollow organ perforations and are associated with perforations in the colorectal tract. Thus, CRP might be a useful marker for preoperative risk stratification and prediction of the localization of the perforation site.
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses (2013)

Pathogenic microorganisms and toxins have evolved a variety of mechanisms to gain access to the host-cell cytosol and thereby exert virulent effects upon the host. One common mechanism of cellular entry requires trafficking to an acidified endosome, which promotes translocation across the host membrane. To identify small-molecule inhibitors that block this process, a library of 30,000 small molecules was screened for inhibitors of anthrax lethal toxin. Here we report that 4-bromobenzaldehyde N-(2,6-dimethylphenyl)semicarbazone, the most active compound identified in the screen, inhibits intoxication by lethal toxin and blocks the entry of multiple other acid-dependent bacterial toxins and viruses into mammalian cells. This compound, which we named EGA, also delays lysosomal targeting and degradation of the EGF receptor, indicating that it targets host-membrane trafficking. In contrast, EGA does not block endosomal recycling of transferrin, retrograde trafficking of ricin, phagolysosomal trafficking, or phagosome permeabilization by Franciscella tularensis. Furthermore, EGA does not neutralize acidic organelles, demonstrating that its mechanism of action is distinct from pH-raising agents such as ammonium chloride and bafilomycin A1. EGA is a powerful tool for the study of membrane trafficking and represents a class of host-targeted compounds for therapeutic development to treat infectious disease.
Platelet Responsiveness to Aspirin Loading in Patients with ST Elevation MI Undergoing Primary Percutaneous Intervention Is Associated with Myocardial Reperfusion and Clinical Outcome. (2008)

Abstract Background: In patients with stable coronary artery disease, and patients undergoing elective percutaneous coronary intervention (PCI), laboratory resistance to aspirin is associated with a higher incidence of adverse events. Nevertheless, the responsiveness to aspirin in acute myocardial infarction (AMI) and its implications have not yet been investigated. Methods: The study comprised 76 aspirin naïve patients who underwent primary PCI (PPCI) for ST-elevation MI (STEMI). Platelet reactivity was assessed 30–60 mins after a loading dose of 300mg chewable aspirin, by conventional aggregometry and Impact R, where platelet reactivity to arachidonic acid (AA) was expressed by platelet deposition under flow conditions. Results: Patients were stratified using the median value of AA-induced platelet aggregation (PA) (49%) to good responders to aspirin (n=38), who had a median AA-induced PA of 33% (25–41), and poor responders to aspirin (n=38), who had a median AA-induced PA of 77% (70–84). Similarly, good compared with poor responders had higher surface coverage by Impact R (3.9±2.6 vs. 2.2±1.3, p=0.003). Good versus poor responders were similar regarding baseline demographic, clinical and angiographic characteristics. However, good responders were more likely to demonstrate early ST-segment resolution ≥ 70% after PPCI (84% vs 54%, p &amp;lt;0.01), suggestive of better myocardial reperfusion. Good compared to poor responders had a lower incidence of adverse cardiovascular events (re-infarction, need for re-intervention, congestive heart failure and/or death) throughout a 6-month follow-up (11% vs 24%, respectively; p&amp;lt;0.05). Conclusions: Ex vivo poor platelet responsiveness to aspirin loading in STEMI patients is associated with a worse prognosis in patients
Usability of 3D-Sound for Navigation in a Constrained Virtual Environment (2006)

This paper presents a study on a global evaluation of spatial auditory displays in a constrained virtual environment. Forty subjects had to find nine sound sources in a virtual town, navigating by using spatialized auditory cues that were delivered differently in four different conditions: by a binaural versus a stereophonic rendering (through headphones) combined by a contextualized versus decontextualized presentation of information. Behavioral data, auto-evaluation of cognitive load and subjective-impression data collected via a questionnaire were recorded. The analysis shows that the binaural-contextualized presentation of auditory cues leads to the best results in terms of usability, cognitive load and subjective evaluation. However, these advantages are only observable after a certain period of acquisition.
When Incest is Not a Taboo: Desire and the Land in Eugene O'Neill's Desire Under the Elms and Marina Carr's On Raftery's Hill (2010)

The American playwright Eugene O'Neill, who had an Irish-born father, can be studied with profit alongside Marina Carr, a contemporary Irish woman dramatist, in that both of them present not only relevant Irish heritage in their works but also a shared interest in the incestuous relationships in Greek tragedies. Although their plays are not on the grand scale of Phaedra or Oedipus, O'Neill, having been an editor for a collection of Greek dramas, and Carr, who has written over thirty adaptations of Greek tragedies, both dramatize the incestuous lust of their countrymen in Desire under the Elms (1924) and On Raftery's Hill (2000), respectively. Incestuous passion, however, is not simply, as Sigmund Freud suggests, an expression of inherent but repressed sexual love between family members, but is mixed with desire for the legitimate inheritance of land and self-recognition. Although O'Neill and Carr both apply social ethics to these tragic family affairs, they introduce an unconventional, and not necessarily celebrated, presentation of incest, so as to challenge this taboo and the patriarchal violence to which the father figures in both plays resort and impose on their families. O'Neill's and Carr's reinterpretations of incest in rural settings across the Atlantic Ocean and almost seven decades both question the stereotypical, often male-privileged depiction of resentful female victims in Greek tragedies. This paper will therefore examine how the two playwrights-with Irish connections abroad and at home-dramatize the Oedipus and Electra complexes of the characters, and the playwrights' interrogation of the social mechanisms to which their characters are subject.
A candidate gene study of the type I interferon pathway implicates IKBKE and IL8 as risk loci for SLE (2010)

Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease in which the type I interferon pathway has a crucial role. We have previously shown that three genes in this pathway, IRF5, TYK2 and STAT4, are strongly associated with risk for SLE. Here, we investigated 78 genes involved in the type I interferon pathway to identify additional SLE susceptibility loci. First, we genotyped 896 single-nucleotide polymorphisms in these 78 genes and 14 other candidate genes in 482 Swedish SLE patients and 536 controls. Genes with P<0.01 in the initial screen were then followed up in 344 additional Swedish patients and 1299 controls. SNPs in the IKBKE, TANK, STAT1, IL8 and TRAF6 genes gave nominal signals of association with SLE in this extended Swedish cohort. To replicate these findings we extracted data from a genomewide association study on SLE performed in a US cohort. Combined analysis of the Swedish and US data, comprising a total of 2136 cases and 9694 controls, implicates IKBKE and IL8 as SLE susceptibility loci (P(meta)=0.00010 and P(meta)=0.00040, respectively). STAT1 was also associated with SLE in this cohort (P(meta)=3.3 × 10⁻⁵), but this association signal appears to be dependent of that previously reported for the neighbouring STAT4 gene. Our study suggests additional genes from the type I interferon system in SLE, and highlights genes in this pathway for further functional analysis.
A truncated and dimeric format of an Affibody library on bacteria enables FACS‐mediated isolation of amyloid‐beta aggregation inhibitors with subnanomolar affinity (2015)

The amyloid hypothesis suggests that accumulation of amyloid β (Aβ) peptides in the brain is involved in development of Alzheimer's disease. We previously generated a small dimeric affinity protein that inhibited Aβ aggregation by sequestering the aggregation prone parts of the peptide. The affinity protein is originally based on the Affibody scaffold, but is evolved to a distinct interaction mechanism involving complex structural rearrangement in both the Aβ peptide and the affinity proteins upon binding. The aim of this study was to decrease the size of the dimeric affinity protein and significantly improve its affinity for the Aβ peptide to increase its potential as a future therapeutic agent. We combined a rational design approach with combinatorial protein engineering to generate two different affinity maturation libraries. The libraries were displayed on staphylococcal cells and high-affinity Aβ-binding molecules were isolated using flow-cytometric sorting. The best performing candidate binds Aβ with a KD value of around 300 pM, corresponding to a 50-fold improvement in affinity relative to the first-generation binder. The new dimeric Affibody molecule was shown to capture Aβ1-42 peptides from spiked E. coli lysate. Altogether, our results demonstrate successful engineering of this complex binder for increased affinity to the Aβ peptide.
Determinants of Successful CD8+ T-Cell Adoptive Immunotherapy for Large Established Tumors in Mice (2011)

Collectively, these findings elucidate some of the key determinants of successful ACT immunotherapy for the treatment of cancer in mice and further show that γ(c) cytokines offer a similar ability to effectively drive antitumor T-cell function in vivo.
Author Correction: ADAMTS-13 regulates neutrophil recruitment in a mouse model of invasive pulmonary aspergillosis (2018)

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Quantitative flow phantom for contrast-enhanced breast tomosynthesis (2007)

The use of contrast agents can help to overcome a lack of intrinsic radiographic contrast between malignant and benign breast tissue by taking advantage of the properties of tumour angiogenesis. Studies of contrast-enhanced mammography have demonstrated increased lesion conspicuity and have shown that this technique provides information on contrast uptake kinetics. It has been suggested that malignant and benign lesions can be differentiated in part by their uptake kinetics, so this additional data may lead to more accurate diagnoses. Tomosynthesis is a 3D x-ray imaging technique that permits lesion depth localization and increased conspicuity in comparison with 2D x-ray projection techniques. This modality, used in combination with contrast agents, promises to be a sensitive method of breast cancer detection. To develop the technique of contrast-enhanced breast tomosynthesis, a dynamic flow phantom has been constructed to provide the same types of imaging challenges anticipated in the clinical setting. These challenges include a low-contrast tumour space, relevant temporal contrast agent uptake and washout profiles, and a need for quantitative analysis of enhancement levels. The design of a flow phantom will be presented that includes a dynamic tumour space, a background that masks the tumour space in images without contrast enhancement, and flow characteristics that simulate tumour contrast agent uptake and washout kinetics. The system is calibrated to relate signal to concentration of the contrast agent using a well plate filled with iodinated water. Iodine detectability in the flow phantom is evaluated in terms of the signal-difference-to-noise ratio for various tomosynthesis image acquisition parameters including number of acquired angular views, angular extent, and reconstruction voxel size.
Effect of Degraded Additives on Under-Fill TSV (2016)

In the past few years the 3D IC integration (3DI) stacking has emerged as a potentially novel approach for extending computing performance without the high cost of CMOS scaling. The 3DI stacking technology is thought to be the essential technology of the next generation high-end semiconductors which will provides improved performance, and reduced form factor for applications such as logic-memory integration, image sensors, MEMS, and LED. The through silicon via (TSV) is one of the main components for 3DI stacking. Copper plating has been used for TSV metallization due to its low resistivity, low cost, excellent plating efficiency, easy to integrate, excellent reliability and a unique bottom up fill capability in presence of additives in the plating bath. One of the major challenges in the TSV metallization by plating is embedded voids and underfill TSV. Among the many parameters in TSV plating; bath composition especially suppressor to accelerator ratio (S/A) significantly affects TSV under-fill. It has been seen that the additives also degrades over the shelf life aging depends on their storage condition. Since the degradation of both suppressor and accelerator is not happening in the same rate, the S/A ratio vary and thus found to be caused TSV under-fill. Fig. 1(a) shows a cross-section SEM image of a TSV plated with BKM bath additives for 1600s. In contrast, Fig. 1(b) and 1(c) shows cross-section SEM images those were plated with same amount of BKM accelerator but with 10% and 25% less suppressor than the BKM respectively. It can be seen that the growth of copper inside the TSV increased~ 33% (with 25% lower suppressor) than the POR without increase of Cu film thickness on side wall, Chamfers and field area. Similarly, for a given suppressor, the copper fill rate can also varied by varying the accelerator concentration. In this paper, we will describe how additives affect the TSV under-fill and correlate the TSV under-fill with degradation of additives during their shelf life aging. Fig. 1(a) Cross-section SEM image of a TSV deposited with BKM plating additives of accelerator and suppressor and plating process for 1600s. Fig.1 (b) and (c) shows cross –section SEM images of a TSV those were plated with same amount of BKM accelerator but 10 and 25% less suppressor respectively than the BKM condition but exactly same plating process and time as Fig 1a Figure 1
Dynamic Gas Environmental System Development for in situ Real-time SEM Imaging under Atmospheric Pressure (2015)

Journal Article Dynamic Gas Environmental System Development for in situ Real-time SEM Imaging under Atmospheric Pressure Get access Takeshi Daio, Takeshi Daio International Research Center for Hydrogen EnergyNext-Generation Fuel Cell Research Center (NEXT-FC)Faculty of Engineering, Department of Hydrogen Energy Systems Search for other works by this author on: Oxford Academic Google Scholar Hai-Wen Li, Hai-Wen Li International Research Center for Hydrogen EnergyInternational Institute for Carbon-Neutral Energy Research (WPI-I2CNER) Search for other works by this author on: Oxford Academic Google Scholar Takashi Gondo, Takashi Gondo Department of Material Science and EngineeringMel-Build Corporation, 3-1-15 Shimoyamato, Nishi-ku, Fukuoka 819-0052, Japan Search for other works by this author on: Oxford Academic Google Scholar Hiroya Miyazaki, Hiroya Miyazaki Mel-Build Corporation, 3-1-15 Shimoyamato, Nishi-ku, Fukuoka 819-0052, Japan Search for other works by this author on: Oxford Academic Google Scholar Tatsuya Ikuta, Tatsuya Ikuta Department of Aeronautics and Astronautics, Kyushu University, Motooka 744, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar Takashi, Takashi Search for other works by this author on: Oxford Academic Google Scholar Nishiyama, Nishiyama Department of Aeronautics and Astronautics, Kyushu University, Motooka 744, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar Koji Takahashi, Koji Takahashi International Institute for Carbon-Neutral Energy Research (WPI-I2CNER)Department of Aeronautics and Astronautics, Kyushu University, Motooka 744, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar Yasuyuki Takata, Yasuyuki Takata International Institute for Carbon-Neutral Energy Research (WPI-I2CNER)Department of Aeronautics and Astronautics, Kyushu University, Motooka 744, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar Stephen Matthew Lyth, Stephen Matthew Lyth International Institute for Carbon-Neutral Energy Research (WPI-I2CNER) Search for other works by this author on: Oxford Academic Google Scholar ... Show more Kazunari Sasaki Kazunari Sasaki International Research Center for Hydrogen EnergyNext-Generation Fuel Cell Research Center (NEXT-FC)Faculty of Engineering, Department of Hydrogen Energy Systems Search for other works by this author on: Oxford Academic Google Scholar Microscopy and Microanalysis, Volume 21, Issue S3, 1 August 2015, Pages 1701–1702, https://doi.org/10.1017/S1431927615009289 Published: 23 September 2015
Thermodynamic functions of thermotropic polyethers based on the semiflexible mesogen 1‐(4‐hydroxyphenyl)‐2‐(2‐methyl‐4‐hydroxyphenyl)ethane (1994)

Abstract Heat capacities of a series of thermotropic polyethers consisting of a semiflexible mesogen [1‐(4‐hydroxyphenyl) ‐ 2 ‐ (2 ‐ methyl ‐ 4 ‐ hydroxyphenyl)ethane], with n methylene flexible spacers (n = 4–12) (MBPE‐n) have been measured by DSC and fitted at low temperature to an approximate frequency spectrum, as well as at high temperature to a general equation for the liquid MBPE‐n. The latter equation is: C p = n(17.33 + 0.04551T) + (280.9 + 0.3839T) where n is the number of methylenes in the polyether spacer. The calculated vibration‐only heat capacities start to show deviations from the measured heat capacities below the melting temperature, reflecting contributions from conformational disorder and motion in methylene spacers. It is suggested that part of this increase in heat capacity can be looked upon as a glass transition of the partially conformationally disordered crystals. Solid state 13 C–NMR studies showed similarly that over the range of temperature some of the CC bonds in the spacer are in a rotational state similar to that in the melt. The equilibrium heats of fusion (ΔH ) and the changes of heat capacity (ΔC p ) for the amorphous polymer at the glass transition temperature, T g , were determined by WAXD and DSC. Based on the discrepancy of ΔC p it is concluded that these phenylene containing polyethers have a certain amount of rigid amorphous polymer. Thermodynamic functions H, S and G for all of the polyethers have been established.