gebhart/patrepeval huggingface dataset:
Reliable Energy Consumption Modeling for an Electric Vehicle Fleet (2022)

Accurately predicting the energy consumption of an electric vehicle (EV) under real-world circumstances (such as varying road, traffic, weather conditions, etc.) is critical for a number of decisions like range estimation and route planning. A major concern for electric vehicle owners is the uncertain nature of the battery consumption. This results in the “range anxiety” and reluctance from users for mass adoption of EVs, since they are concerned about untimely drainage of battery. Even at the organizational level, a company running a fleet of electric vehicles must understand the battery consumption profiles accurately for tasks such as route and driver planning, battery sizing, maintenance planning, etc.
The discovery and development of oncolytic viruses: are they the future of cancer immunotherapy? (2020)

<b>Introduction</b>: Despite diverse treatment modalities and novel therapies, many cancers and patients are not effectively treated. Cancer immunotherapy has recently achieved breakthrough status yet is not effective in all cancer types or patients and can generate serious adverse effects. Oncolytic viruses (OVs) are a promising new therapeutic modality that harnesses virus biology and host interactions to treat cancer. OVs, genetically engineered or natural, preferentially replicate in and kill cancer cells, sparing normal cells/tissues, and mediating anti-tumor immunity.<b>Areas covered</b>: This review focuses on OVs as cancer therapeutic agents from a historical perspective, especially strategies to boost their immunotherapeutic activities. OVs offer a multifaceted platform, whose activities are modulated based on the parental virus and genetic alterations. In addition to direct viral effects, many OVs can be armed with therapeutic transgenes to also act as gene therapy vectors, and/or combined with other drugs or therapies.<b>Expert opinion</b>: OVs are an amazingly versatile and malleable class of cancer therapies. They tend to target cellular and host physiology as opposed to specific genetic alterations, which potentially enables broad responsiveness. The biological complexity of OVs have hindered their translation; however, the recent approval of talimogene laherparepvec (T-Vec) has invigorated the field.
An extension of the Multipeak speech processing strategy for the MSP/MINI 22 cochlear implant system (1992)

The speech perception of three post-linguistically deaf adults using the Nucleus MSP/Mini System 22 cochlear implant system programmed with a new speech processing strategy, MPEAK+AO. was evaluated. The MPEAK+AO strategy retains all the information of the standard Multipeak speech processing strategy and additionally presents acoustic components below 400Hz to the most-apical electrode. This extra spectral Information may help implantees understand speech, particularly in noise. Since the estimated fundamental frequency is presented as the rate of stimulation at a fixed intracochlear site and is thereby potentially perceived more easily. and the amplitude of the stimulation on the apical electrode, associated with the voice fundamental, Is directly determined from the estimated energy in the relevant spectral region. these coding factors may provide a better representation ot the prosodic information in speech and a more complete auditory feedback signal. The comparison between Multipeak and MPEAK+AO included tests of vowel, consonant and CNC word recognition. Speech materials were presented with both a male and female speaker. Sentence material. presented with background masking noise (four-speaker babble) was also used. The results showed that the new strategy significantly improved the ability of these MSP users to recognise words in open-set sentences in noisy conditions.
RF-IDraw (2014)

In this extended abstract, we discuss high-level design principles and future applications that can be enabled by RF-IDraw, an RF-based trajectory tracing system originally proposed in [16]. RF-IDraw achieves trajectory tracing accuracy of a few centimeters and hence, enables novel applications in gaming, gesture based interfaces, indoor navigation and the like, using RF-signals which could not be possible with existing RF positioning systems.
GA201: A Novel Humanized and Glycoengineered Anti-EGFR Antibody—Response (2014)

We are pleased that Dr. Modjtahedi found our work on GA201 interesting. The origin of the CDR sequences of GA201 based on the published sequences of the ICR62 antibody is clearly mentioned in our publication ([1][1]). Likewise, previous publications describing the properties of ICR62 were also cited
Regression of the epithelium in late previtellogenic follicles of Podarcis sicula: A case of apoptosis (1996)

We investigated the reorganization of the follicular epithelium at the end of previtellogenesis in the lizard Podarcis sicula. In particular, we determined the mechanism of intermediate and pyriform cell regression and the fate of their different subcellular constituents. Morphological and biochemical analyses revealed the presence of hallmarks of apoptosis such as nuclear changes, chromatin condensation, protein scaffolds, RNA synthesis, and DNA fragmentation. It was therefore concluded that the remodelling of the follicular epithelium is associated with programmed cell death. Evidence was also obtained that during regression, the cytoplasmic constituents of intermediate and pyriform cells are transferred into the oocyte while the remnants of the nuclei are recycled by the small cells. The functional significance of these events is discussed. © 1996 Wiley-Liss, Inc.
Joint ray launching method for indoor to outdoor propagation prediction based on Ray Aggregation (2015)

A joint indoor to outdoor ray launching algorithm is proposed in this paper. Different resolutions are considered for indoor and outdoor simulations. Instead of using conventional sampling technique to extract rays from a finer resolution, a novel method, named Ray Aggregation, is applied to minimise the loss of accuracy while benefiting from the computational cost of a coarse resolution. Furthermore, this model will be demonstrated with two simulations based on the general 2.4 GHz 802.11n wireless local area network. Finally, the corresponding measurements will be presented to verify the accuracy of the proposed model.
MINFLUX nanoscopy delivers multicolor nanometer 3D-resolution in (living) cells (2019)

The ultimate goal of biological superresolution fluorescence microscopy is to provide three-dimensional resolution at the size scale of a fluorescent marker. Here, we show that, by localizing individual switchable fluorophores with a probing doughnut-shaped excitation beam, MINFLUX nanoscopy provides 1–3 nanometer resolution in fixed and living cells. This progress has been facilitated by approaching each fluorophore iteratively with the probing doughnut minimum, making the resolution essentially uniform and isotropic over scalable fields of view. MINFLUX imaging of nuclear pore complexes of a mammalian cell shows that this true nanometer scale resolution is obtained in three dimensions and in two color channels. Relying on fewer detected photons than popular camera-based localization, MINFLUX nanoscopy is poised to open a new chapter in the imaging of protein complexes and distributions in fixed and living cells.
Dietary myo-inositol therapy in hyperglycemia-induced embryopathy (1998)

Dysmorphogenesis in diabetic mothers occurs more frequently than in the general population. This phenomenon is believed to be caused by the teratogenic effects of metabolic fuel mixtures with associated membrane injury and aberrations in the biochemical constituents. The present experiment was designed to determine: 1) if hyperglycemia-induced membrane injury is associated with intracellular and/or extracellular lipid disturbances; 2) if supplemental myo-inositol therapy prevents hyperglycemia-induced embryopathy; 3) if a correlation exists between dietary myo-inositol, serum and tissue levels of myo-inositol, and conceptus development; and 4) the cellular content of arachidonic acid following myo-inositol supplementation. Sixty-five female Sprague-Dawley rats were mated, and divided into three groups. One group was nondiabetic normal controls, and two groups had diabetes experimentally induced with streptozotocin. Of the diabetic groups, one received a normal diet, while the other received a myo-inositol-supplemented diet during the period of organogenesis. Blood samples were collected on days 0 and 12 of pregnancy. Embryos and yolk sacs were analyzed for myo-inositol and arachidonic acid levels, using mass spectrochromatography. Dietary myo-inositol supplementation of diabetic mothers resulted in a significant decrease in the incidence of neural tube defects when compared with diabetics not receiving supplements (9.5 vs. 20.4%; P < 0.05). This protective effect was incomplete, based on the incidence observed in the nondiabetic controls (9.5 vs. 3.8%; P < 0.05). The myo-inositol embryonic tissue levels in the diabetic group which had been fed a regular diet without supplementation were significantly lower than in the nondiabetic group. Dietary therapy successfully restored myo-inositol levels in the yolk sacs, as suggested by similar tissue levels in diabetics receiving myo-inositol supplementation and normal controls (18.7 +/- 1.3 vs. 19.1 +/- 2.0 ng/mg; P = ns). Dietary therapy, however, failed to restore myo-inositol levels in the embryos, suggesting hyperglycemia-induced faulty transport of nutrients from the yolk sac to the embryo. No correlation was noted between maternal blood levels of myo-inositol, with or without supplementation, and the clinical outcome. Tissue arachidonic acid levels were markedly reduced in the conceptuses of diabetic mothers with (0.4 +/- 0.1 micrograms/mg) or without (0.25 +/- 0.08 micrograms/mg) myo-inositol supplementation when compared to the nondiabetic controls (3.33 +/- 0.24 micrograms/mg). These data demonstrate that diabetes-induced embryopathy is associated with a deficiency state in both myo-inositol and arachidonic acid. The myo-inositol deficiency is not demonstrated at the serum level, but rather at the tissue level, suggesting a paracrine action. Dietary supplementation of myo-inositol is associated with an increase in tissue myo-inositol levels and a decrease in malformations. This therapy holds promise for use as a dietary prophylaxis against diabetic embryopathy.
Plasma lipid and blood glucose levels in patients with destructive periodontal disease (2000)

Hyperlipidaemia and hyperglycaemia are major risk factors for cardiovascular disease. In recent years, some evidence has been presented that periodontal disease is associated with an increased risk of cardiovascular disease. To further elucidate this association, we have studied standard blood chemistry variables known as risk markers for cardiovascular disease in periodontally diseased and healthy subjects. We have measured levels of plasma lipids and fasting blood glucose in 39 subjects with moderate periodontal disease (age 50-60 years) and compared the results with those obtained in 40 age- and sex-matched controls. Both groups were systemically healthy according to their medical history. Total cholesterol, low density lipoprotein cholesterol and triglycerides were significantly higher in periodontally diseased subjects by about 8% (p<0.03), 13% (p<0.003) and 39% (p<0.001), respectively, when compared to controls. Although subjects with diabetes were excluded from the study, we found significantly higher blood glucose levels in the patient than in the control group (85 +/- 25 versus 73 +/- 17 mg/dl; p<0.02). There was also a significantly higher frequency of pathological plasma lipid profiles in the patient than in the control group. The results indicate that hyperlipaemia and pre-diabetes may be associated with periodontal disease in systemically healthy subjects. These data do not allow us to decide, whether periodontal disease causes an increase in hyperlipaemia and in a prediabetic state or whether periodontal disease and cardiovascular disease share hyperlipidaemia and the prediabetic state as common risk factors.
Subpixel rendering method for color error minimization on subpixel structured display (2006)

This study investigates the color error problems posed by large flat panel displays and proposes a subpixel-rendering algorithm to mitigate the problem. The color error problems are caused by Mach band effect and the convergence error of a pixel on large subpixel structured displays and named a color band error. The proposed method includes three processes; a finding process of areas or pixels generating the error, an estimating process of the error, and a correction process of the error. To correct the color band error, we take an error erosion approach, an error concealment approach, and a hybrid approach of the error erosion and the error concealment. In this paper, we experimented to know the threshold where human vision can detect by a psychophysical method. In addition, we applied our proposed method to a commercial 42" plasma display to confirm the effect. The results show that all observers see the color band error at a sharp edge having above 64-gray difference and the converted test images by our algorithm are preferred to the original test images. Finally, this paper reports that the Mach band effect and the convergence error on large subpixel structured display produce color band errors on images having sharp edge and the proposed method effectively corrects the color band errors.
Recombinant human macrophage colony-stimulating factor in nonhuman primates: selective expansion of a CD16+ monocyte subset with phenotypic similarity to primate natural killer cells (1996)

The CD16 receptor (Fc gamma R-III) is found on many tissue macrophages (M phi s), but its expression on circulating monocytes is restricted to a small, phenotypically distinct subset. The number of these CD16+ monocytes may be markedly increased in response to sepsis, human immunodeficiency virus infection, or metastatic malignancy. We have recently shown that the CD16+ monocyte population is selectively expanded by administration of recombinant human macrophage colony-stimulating factor (rhM-CSF). In the current study, we used the highly rhM-CSF-responsive cynomolgus primate model to further characterize this novel monocyte population. Animals treated with rhM-CSF underwent a progressive and essentially complete conversion to the CD16+ monocyte phenotype, with up to a 50-fold increase in the number of CD16+ cells. This increase was paralleled by the emergence of a population of circulating cells that morphologically resembled large granular lymphocytes (LGLs). However, quantitatively, this population corresponded closely to the number of CD16+ monocytes, and fluorescence-activated cell sorting (FACS) confirmed that they were the same. In addition to their LGL-like morphology, many rhM-CSF-induced CD16+ monocytes showed a pattern of size, granularity, and quantitative cell surface marker expression that closely resembled the pretreatment LGL/natural killer (NK) cell population but that did not resemble the pretreatment monocyte population. However, rhM-CSF-induced CD16+ monocytes could be distinguished from LGL/ NK cells by fact that they all expressed cell surface receptors for rhM-CSF, and many of them showed reduced but detectable phagocytic and respiratory burst activity. Studies of human subjects treated with rhM-CSF also showed an analogous population of "LGL-appearing" CD16+ mononuclear cells. Thus, our studies reveal a previously unsuspected ability of cells in the monocyte lineage to adopt a phenotype similar to that of LGL/NK cells. The extent of this phenotypic convergence suggests that the two lineages retain access to elements of a similar developmental pathway.
Reservation Based QoS Provision for Mobile Environments (2001)

With the fast adoption of IP-based communications for mobile computing, users are expecting a similar service in wireless and wired networks. This raises the need for setting guarantees to the quality of the offered service (QoS), despite the technology of the access network or the mobility of the terminal. This generates a new challenge for QoS provision, as it will have to deal with terminals changing their point of attachment to the network. In this paper an optimisation for the operation of reservation based QoS is given for mobile environments: the coupling of the reservation protocol RSVP with different perhost micro-mobility protocols. The micro-mobility and QoS signalling mechanism are coupled either loosely via a triggering mechanism, or more tightly so the QoS and mobility information is carried by the same protocol. Qualitative and quantitative results of this coupling are presented. The procedure includes the comparison of performance parameters such as delay, loss and throughput when protocols are coupled and de-coupled KEY WORDS: QoS, micro-mobility, mobile networks, coupling, RSVP,HAWAII.
Generation of sub-half-cycle 10 µm pulses using four-wave mixing through two-color filamentation (2021)

Carrier-envelope phase (CEP)-stable sub-cycle mid-infrared (MIR) pulses play an important role to investigate field-sensitive nonlinear processes. In this contribution, we report the generation of sub-half-cycle phase-stable pulses with the carrier wavelength of( ω 1 ) and second harmonic (SH, ω 2 ) of sub-milli joule 35 fs pulses at 800 nm were focused into nitrogen gas at∼10 µm through two-color filamentation in nitrogen [1] . The fundamental atmospheric pressure. Broadband MIR pulses ( ω 0 ) were generated through the four-wave mixing (FWM) process, ω 1 + ω 1 − ω 2 → ω 0 . Typical MIR spectra at four different phase delay lengths between the fundamental and SH.2µm. The input pulses are shown in Fig. 1(a) . The center of mass of the spectrum at zero phase delay lengths is 10 spectrum is spread from 4.90 to 43.1µm (from 2040 to 232cm− 1 ), which corresponds to more than three octaves with full width at tenth maximum. The pulse energy was 0.42µJ, which would be high enough for high harmonic generation in solids.
Influence of surgical technique in the peritoneal carcinomatosis surgical wound implant: experimental model in mice (2015)

Tumor infiltration into the wound was more intense in the group in which the protection of the surgical site was not performed, and in females when compared to males of the same group.
Forced chromatin looping raises fetal hemoglobin in adult sickle cells to higher levels than pharmacologic inducers (2016)

Overcoming the silencing of the fetal γ-globin gene has been a long-standing goal in the treatment of sickle cell disease (SCD). The major transcriptional enhancer of the β-globin locus, called the locus control region (LCR), dynamically interacts with the developmental stage-appropriate β-type globin genes via chromatin looping, a process requiring the protein Ldb1. In adult erythroid cells, the LCR can be redirected from the adult β- to the fetal γ-globin promoter by tethering Ldb1 to the human γ-globin promoter with custom-designed zinc finger (ZF) proteins (ZF-Ldb1), leading to reactivation of γ-globin gene expression. To compare this approach to pharmacologic reactivation of fetal hemoglobin (HbF), hematopoietic cells from patients with SCD were treated with a lentivirus expressing the ZF-Ldb1 or with chemical HbF inducers. The HbF increase in cells treated with ZF-Ldb1 was more than double that observed with decitabine and pomalidomide; butyrate had an intermediate effect whereas tranylcypromine and hydroxyurea showed relatively low HbF reactivation. ZF-Ldb1 showed comparatively little toxicity, and reduced sickle hemoglobin (HbS) synthesis as well as sickling of SCD erythroid cells under hypoxic conditions. The efficacy and low cytotoxicity of lentiviral-mediated ZF-Ldb1 gene transfer compared with the drug regimens support its therapeutic potential for the treatment of SCD.
A comprehensive global review of building integrated photovoltaic systems (2021)

Saudi Arabia has embarked on diversification of its existing energy portfolio through rene wables, mainly solar photovoltaic and thermal, and wind power. This study presents an overview of how different areas around the world utilized building-integrated solar photovoltaic applications to recommend appropriate and suitable options for implementation in Saudi Arabia and the Middle East region. With this objective, the power utility will have three-fold benefits (i) clean and economic power arability for off-grid remotely located dwellings, (ii) cutting down the emissions of greenhouse gases, and (iii) conserving the fixed reserves of fossil fuels, which are being used mainly for power production around the world. The study shows that building-integrated applications are most common in Asian and European countries. Moreover, it is observed that monocrystalline and polycrystalline photovoltaic materials are both technologically and economically suitable for such applications.
Structural characterization of unsaturated glycerophospholipids by multiple-stage linear ion-trap mass spectrometry with electrospray ionization (2008)

Structural elucidation of glycerophospholipids (GPLs), including the polar head group, the position of double-bond(s) along the fatty acyl substituents, and the positions of acyl groups on the glycerol backbone, using multiple-stage liner ion-trap (LIT) mass spectrometric approach is described in this paper. While the product-ion spectra from MSn (n=2, 3) on the [M+Li]+ or [M-H+2Li]+ ions of GPL are readily applicable for discerning the phospholipid classes and for identifying and locating the fatty acid substituents on the glycerol backbone, the structural information from further dissociation of the dilithiated fatty acid cations produced from MSn (n=3, 4) on the [M-H+2Li]+ ion of GPLs, as well as from further dissociation of the monolithiated fragment ion that bears the unsaturated fatty acid moiety produced from subsequent MSn (n=3,4) on the [M+Li]+ ions of GPLs, affords assignment of the position of double-bond(s) along the fatty acyl groups. The application of the present method in the structural characterization of GPL molecules from the lipid extracts of biological origin, including mixtures of phosphatidylglycerol and of phosphatidylserine without prior chromatographic separation, is also demonstrated. Since lithiated molecular species of GPL are readily formed by ESI, this multiple-stage LIT mass spectrometric approach provides a direct means for the near-complete structural characterization of all the GPLs, including the molecules in the lysophospholipid and plasmalogen subclasses.
Silicon Photonics R&amp;D and Manufacturing on 300-mm Wafer Platform (2015)

Industrial implementation of a silicon photonics platform using 300-mm SOI wafers and aiming at 100 Gb/s aggregate data-rate application is demonstrated. The integration strategy of electronic and photonic ICs, 300-mm process flow, and process variability are discussed, and performances of the passive and active optical devices are shown. An example of a low-cost LGA-based package together with a fiber assembly is given. RX and TX circuits operating at 25 Gb/s are demonstrated. Finally, the process evolution toward the integration of the backside reflector and multiple silicon etching level is demonstrated.
Preface (2014)

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Contribution of Articular Surface Geometry to Ankle Stabilization (2006)

The documented changes in contact stress illustrate the major role of articular geometry in passive ankle stabilization. The levels of contribution by the articular surface that we calculated are consistent with those reported in the literature. These findings support the conceptual mechanism of ankle stabilization by redistribution of articular contact stress.