gebhart/patrepeval huggingface dataset:
Collagen-Based Photoactive Agent for Tissue Bonding (2017)

Using a combination of methacrylated collagen and the photosensitizer rose Bengal, a new light-activated biomimetic material for tissue sutureless bonding was developed. This formulation was cross-linked using green light. In vivo tests in mice demonstrate the suitability of the material for sutureless wound closure.
Identification of 2,3‐Diaryl‐pyrazolo[1,5‐b]pyridazines as Potent and Selective Cyclooxygenase‐2 Inhibitors. (2005)

Abstract For Abstract see ChemInform Abstract in Full Text.
Direct Superresolution Technique for Solving a Miniature Multi-Shift Imaging System (2015)

Regularized superresolution techniques incorporate optimizers and priors to deliver appealing restorations even though deviating from the physical reconstructions. We propose a non-regularized superresolution algorithm that directly solves a fully-characterized multi-shift imaging system to grant realistic restorations without such constraints.
The mechanism of the glycosylase reaction with hOGG1 base-excision repair enzyme: concerted effect of Lys249 and Asp268 during excision of 8-oxoguanine (2017)

The excision of 8-oxoguanine (oxoG) by the human 8-oxoguanine DNA glycosylase 1 (hOGG1) base-excision repair enzyme was studied by using the QM/MM (M06-2X/6-31G(d,p):OPLS2005) calculation method and nuclear magnetic resonance (NMR) spectroscopy. The calculated glycosylase reaction included excision of the oxoG base, formation of Lys249-ribose enzyme-substrate covalent adduct and formation of a Schiff base. The formation of a Schiff base with ΔG# = 17.7 kcal/mol was the rate-limiting step of the reaction. The excision of the oxoG base with ΔG# = 16.1 kcal/mol proceeded via substitution of the C1΄-N9 N-glycosidic bond with an H-N9 bond where the negative charge on the oxoG base and the positive charge on the ribose were compensated in a concerted manner by NH3+(Lys249) and CO2-(Asp268), respectively. The effect of Asp268 on the oxoG excision was demonstrated with 1H NMR for WT hOGG1 and the hOGG1(D268N) mutant: the excision of oxoG was notably suppressed when Asp268 was mutated to Asn. The loss of the base-excision function was rationalized with QM/MM calculations and Asp268 was confirmed as the electrostatic stabilizer of ribose oxocarbenium through the initial base-excision step of DNA repair. The NMR experiments and QM/MM calculations consistently illustrated the base-excision reaction operated by hOGG1.
Cardiac Mortality Spikes at Christmas and New Year's (2005)

Is the increase in mortality during the winter attributable to the season itself or to winter holidays specifically? To find out, researchers analyzed
Valproic acid: A viable alternative to sodium butyrate for enhancing protein expression in mammalian cell cultures (2008)

Various DNA methyl transferase inhibitors (iDNMTs) and histone deacetylase inhibitors (iHDACs) were screened for their ability to enhance transient gene expression (TGE) in Human Embryonic Kidney 293-EBNA (HEK293E) cells. The effects in HEK293E cells were compared to those in Chinese Hamster Ovary DG44 (CHO-DG44) cells. The iDNMTs and iHDACs were chosen based on their different cellular activities and mechanisms of action. For each inhibitor tested, the optimum concentration was determined for both cell lines, and these conditions were used to evaluate the effect of each compound using a recombinant monoclonal antibody as a reporter protein. All the iHDACs increased transient antibody yield at least 4-fold in HEK293E and at least 1.5-fold in CHO-DG44. By comparison, the iDNMTs increased antibody yields by a maximum of approximately 2-fold. Pairwise combinations of iDNMTs and iHDACs had a linearly additive effect on TGE in CHO-DG44 but not in HEK293E. With valproic acid (VPA), volumetric and specific productivities of 200 mg/L and 20 pg/cell/day, respectively, were achieved in HEK293E cells with a 10-day process. As VPA is both FDA-approved and 5-fold less expensive than sodium butyrate (NaBut), we recommend it as a cost-effective alternative to this widely used enhancer of recombinant protein production from mammalian cells.
Double dissociation between representational personal and extrapersonal neglect (2006)

These data suggest that the cerebral networks that process mental space representation use similar principles of space compartmentalization as those used by cerebral networks processing perceived space.
Yb3+-doped ceramic lasers (2004)

We have been succeeding in fabrication of highly transparent ceramics with vacuume sitering method and nanocrystalline technology. Femtosceond ceramic lasers and highly efficient cw ceramic lasers were developed with Yb-doped ceramics. A cw Yb3+-doped Y2O3 ceramic laser was demonstrated with the extraction efficiency of 72 %. A modelocked Yb3+-doped Y2O3 ceramic laser were demonstrated with a semiconductor saturable-absorber mirror. The modelocked laser generated 78 MHz and 615 fs pulses. The average power of 420 mW, and the pulse energy of 4.3 nJ at a 2.5 W absorbed pump power.
Nanosized microporous crystals: emerging applications (2015)

This review highlights recent developments in the synthesis and unconventional applications of nanosized microporous crystals including framework (zeolites) and layered (clays) type materials. Owing to their microporous nature nanosized zeolites and clays exhibit novel properties, different from those of bulk materials. The factors controlling the formation of nanosized microporous crystals are first revised. The most promising approaches from the viewpoint of large-scale production of nanosized zeolites and clays are discussed in depth. The preparation and advanced applications of nanosized zeolites and clays in free (suspension and powder forms) and fixed (films) forms are summarized. Further the review emphasises the non-conventional applications of new porous materials. A comprehensive analysis of the emerging applications of microporous nanosized crystals in the field of semiconductor industry, optical materials, chemical sensors, medicine, cosmetics, and food industry is presented. Finally, the future needs and perspectives of nanosized microporous materials (zeolites and clays) are addressed.
Properties of Glass Fiber Reinforced Gypsum Sheets (1977)

To improve the tensile strength and ductility of gypsum, sheets were fabricated by spraying gypsum slurry with chopped glass fibers. The influence of the volume of fibers, length of fibers, the density of the matrix, and the type of matrix on flexural properties and impact strength were studied. Fire tests were also conducted on glass reinforced gypsum sheets. Reinforcing mechanism of glass fibers was examined by optical and scanning electron microscopy.
Reduced Number of Platelets During Intra-Aortic Balloon Pumping Counterpulsation Predicts Higher Cardiovascular Mortality After Device Removal in Association with Systemic Inflammation (2020)

Thrombocytopenia is a frequent complication in patients requiring intra-aortic balloon pumping (IABP) counterpulsation. However, its prognostic impact has not been fully addressed. The objective of this study is to evaluate the impact of the change in the platelet number during IABP use on the prognosis after device removal.This is a retrospective observational study. Patients in the intensive cardiac care unit at three Juntendo University hospitals who underwent percutaneous implantation of IABP with or without veno-arterial extracorporeal membrane oxygenation (V-A ECMO), since 2012-2016, were enrolled in the study (n = 439). Patients who died during mechanical circulatory support (n = 47) were excluded. We evaluated the prognostic impact of the ratio of platelet reduction from the baseline (% PLT reduction) during IABP use on cardiovascular mortality after device removal.The median and the range of follow-up period were 298 days and 0-1,869 days, respectively. Unadjusted Kaplan-Meier analysis demonstrated that patients with a higher % PLT reduction had higher cardiovascular (CV) mortality. An adjusted Cox proportional hazard analysis demonstrated that a 10% higher % PLT reduction was associated with higher cardiovascular (CV) mortality (Hazard ratio: 1.3, 95% Confidence interval: 1.1-1.6, P < 0.001). Moreover, % PLT reduction and the maximum C-reactive protein (CRP) level during IABP use were positively correlated (r = 0.326, P < 0.001).The reduced number of platelets during IABP use was associated with an increased risk of CV mortality.
A Contingent Claims Analysis of Trade Credit (1992)

We investigate trade credit decisions using a framework which reflects capital market equilibrium via contingent claims analysis. We approach the valuation of trade credit from the perspective of straightforward evaluation of risky debt. By modeling the trade credit limit decision in this way, optimal decisions on the part of the seller and buyer are assumed. This paper has two purposes. First, to develop a theoretically plausible credit-valuation framework. Second, to illustrate the proper use of this framework for effectively setting credit limits.
Electrochemical CO<sub>2</sub> Utilization for the Synthesis of α-Hydroxy Acids (2022)

The electrocarboxylation of organic compounds provides a green alternative to the conventional use of cyanides or organometallics. Via a simple electrochemical approach, CO2 can be directly incorporated into aldehydes or ketones to form α-hydroxy acids using electrical energy as a driving force. In this study, propylene carbonate was used as a “green” solvent. Importantly, the use of sacrificial anodes was avoided; instead, cost-efficient and stable graphite anodes were applied. Voltammetric studies on benzaldehyde carboxylation revealed that the presence of CO2 significantly changes the reduction behavior of benzaldehyde at potentials more negative than the potential of the ketyl radical formation. Bulk electrolysis was performed in various solvents and supporting electrolyte systems, leading to more than 55% mandelic acid yield in propylene carbonate. Among the tested solvents (acetonitrile, N,N-dimethylformamide, dimethyl sulfoxide, and propylene carbonate), propylene carbonate resulted in the highest carboxylate yield. Numerous cathode materials were tested. High carboxylate yields were achieved using graphite, glassy carbon, and lead cathodes. The reaction was successfully carried out for various aromatic aldehydes and ketones as substrates, providing yields of up to 63%.
ChemInform Abstract: A <sup>1,3</sup>‐Strain Enabled Retention of Chirality During Bis‐Cyclization of β‐Ketoamides: Total Synthesis of (‐)‐Salinosporamide A and (‐)‐Homosalinosporamide A. (2010)

Abstract (‐)‐Salinosporamide A (IVa) and (‐)‐homosalinosporamide A (IVb) are prepared via a diastereoselective bis‐cyclization of β‐keto tertiary amide of type (II) as key step.
Resonant two-photon terahertz quantum cascade laser (2022)

Lasers that can emit two photons from a single electron relaxation between two states of the same parity have been discussed since the early days of the laser era. However, such lasers have seen only limited success, mainly due to a lack of suitable gain medium. We propose that terahertz (THz) frequency quantum cascade lasers (QCLs) are an ideal semiconductor structure to realize such two-photon emissions. In this work, we present a THz QCL heterostructure designed to emit two resonant photons from each electronic relaxation between two same-parity states in the active region. We present coupled Maxwell-Bloch equations that describe the dynamics of such a two-photon laser and find analytical solutions for the steady-state light intensity, the steady-state energy-resolved carrier densities, and the total threshold carrier density. Due to the two-photon emission from each excited state relaxation and an increased photon-driven carrier transport rate, our simulations predict a significant enhancement of light intensity in our designed resonant two-photon THz QCL when compared to an exemplar conventional THz QCL structure.
Randomized Trial to Compare Smoking Cessation Rates of Snus, With and Without Smokeless Tobacco Health-Related Information, and a Nicotine Lozenge (2018)

This randomized trial of the nicotine lozenge, snus, or snus plus information on the relative risks of smokeless tobacco versus smoking found comparable but low smoking cessation rates for all three groups at weeks 12, 26, and 52. The one-time provision of relative risk information did not lead to greater snus use among those provided the information, suggesting no effect for this brief intervention.
RTHP-28. TTFIELDS TREATMENT AFFECTS TUMOR GROWTH RATES: A POST-HOC ANALYSIS OF THE PIVOTAL PHASE 3 EF-14 TRIAL (2019)

Abstract INTRODUCTION The pivotal EF-14 trial showed that Tumor Treating Fields (TTFields) extend Progression Free Survival (PFS) in newly Diagnosed Glioblastoma (ndGBM) patients. This leads to the hypothesis that TTFields therapy leads to local control of tumors, yielding a significant decrease in tumor growth rates. Here we present an analysis testing this hypothesis in biopsy-only patients who participated in the EF-14 trial. METHODS Biopsy patients of the EF-14 trial who exhibited radiological progression were included in this study (treatment: N=37/60, control: N=12/29). Volumes of enhancing tumor were segmented on T1c MRIs at baseline and at progression. Tumor growth rate was calculated as: growth_rate=(ln(v0)-ln(v1))/dt. (v0- tumor volume at baseline), v1- Tumor volume at progression, dt- days to progression), which models tumor volume as increasing exponentially over time. Median growth rates in the treatment and control arms were compared. RESULTS The median growth rate was lower in the treatment arm than in the control. (control: 0.14±0.12 mL/month, TTFields -0.011±0.11 mL/month, p&lt; 0.008 Wilcoxon rank-sum) DISCUSSION AND CONCLUSIONS This study shows that tumor growth rates are slower in patients treated with TTFileds+Temozolomide (TMZ) than in patients treated with TMZ alone. This analysis was restricted to biopsy-only patients since the definition of tumor volume is ambiguous in patients that underwent resection since a large portion of the tumor has been removed. The negative median growth rate for patients in the treatment arm may indicate that a significant number of TTFields-treated patients a decrease in tumor volume was observed, suggesting that TTFields enhances local tumor control. References: [1] Stupp, Roger, et al. Jama 318.23 (2017): 2306–2316.[[2 Stensjøen, Anne Line, et al. Neuro-oncology 17.10 (2015): 1402–1411.
Abstract 2634: Predictive value of 18F-FDG PET/CT scanning in combination with clinical parameters in patients with newly diagnosed multiple myeloma (2018)

Abstract Objective: To evaluate the association of 18F-2`-deoxy 2`-fluorodeoxyglucose (18F-FDG) PET/CT with clinical parameters in predicting patients with newly diagnosed multiple myeloma (MM). Methods: One hundred and twenty MM patients undergoing 18F-FDG PET/CT scanning were analyzed in a retrospective cohort study. Results: Based on multivariate analysis, β2M, LDH, number of focal lesions (FLs) and SUVmax were significantly correlated with overall survival (OS). These 4 variables were used to construct a new staging system (NSS) based on the number of risk factors. NSS provided a better discrimination of risk between stages III and II than International staging system (ISS) (p &amp;lt; 0.001 vs. p = 0.086). For OS, there was no significant difference among risk groups in Durie-Salmon (DS) stage (p &amp;gt; 0.05). Based on Spearman correlation analysis, presence of lesions in appendicular skeleton, number of FLs and SUVmax appeared to indicate advanced stage of MM. ROC curves which showed the combination of β2M with Calcium got a specificity of 96.3% for the presence of lesions in appendicular skeleton, and LDH alone had 100% specificity in predicting the number of FLs, although the sensitivity was only 50%. Conclusions: 18F-FDG PET/CT in combination with clinical parameters provided an accurate and simple method for risk stratification of patients with newly diagnosed MM. Citation Format: Honglei Tu, Fuling Zhou, Yunbao Pan, Francois X Claret. Predictive value of 18F-FDG PET/CT scanning in combination with clinical parameters in patients with newly diagnosed multiple myeloma [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 2634.
Computationally efficient estimation of frequency response and driving point impedances in wide-band analog amplifiers (1990)

An alternative to traditional dominant and lumped-pole mathematical models of a linear analog circuit is proposed for estimation and sensitivity analysis of bandwidth, phase angle, and driving point impedances in wide-band signal processors. The proposed mathematical model, which accounts for transmission zeros and dominant complex pole pairs, is accurate to errors that are usually less than 15%, regardless of the relative densities of poles and zeros in the complex frequency plane. Although practical implementation of the model requires a personal computer or workstation, the results are computationally efficient since estimates of I/O frequency and phase responses, as well as the frequency response of driving point impedance at any circuit port, derive from only one solution of the circuit equilibrium equations. These results are design-oriented in that the realistic effects on high-frequency performance of potentially large uncertainties in any circuit or model parameter are accurately revealed.< <ETX xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">&gt;</ETX>
Design and Analysis of Broadband Dual-Gate Balanced Low-Noise Amplifiers (2007)

In this paper, we present three MMIC low-noise amplifiers using dual-gate GaAs HEMT devices in a balanced amplifier configuration. The designs target three different frequency bands including 4-9 GHz, 9-20 GHz, and 20-40 GHz. These dual-gate balanced designs demonstrate the excellent qualities of balanced amplifiers in terms of stability and matched characteristics, while demonstrating higher bandwidth than designs with a single-stage common-source device. Additionally, noise performance is excellent, with the 4-9 GHz LNA demonstrating <1.75 dB noise figure (NF), the 9-20 GHz LNA <2.75 dB NF and the 20-40 GHz LNA <2.5 dB NF. Demonstrating high gain and excellent bandwidth, the dual-gate devices seem a logical choice for the balanced amplifier topology.
Extended SWIR imaging for targeting and reconnaissance (2018)

In the recent years AIM has developed IR modules for imaging applications sensitive in the extended SWIR (eSWIR) spectral range with a cut-off wavelength of 2.5μm. The modules are based on AIM’s state-of-the-art MCT FPA technology with a dedicated ROIC integrated in a low size, weight and power (SWaP) Dewar/Cooler configuration. The different modules are either designated to combine emissive and reflective imaging in one sensor by already detecting thermal radiation in the eSWIR band or to make use of laser illumination including gating capability. Further integration including a lens, image processing electronics and power supply was done resulting in sights for targeting and reconnaissance applications. For targeting under low-light conditions a low SWaP MCT eSWIR module in a 640x512 format with 10μm pitch was developed. The module was integrated to a compact clip-on weapon sight for small arms providing medium range performance up to 1000m. For reconnaissance applications a MCT based SWIR 2D APD array in a 640x512 15&mu;m pitch format was developed providing gated viewing capability. The device was optimized to provide a higher gain for improvement of the signal to noise ratio (SNR). The module was integrated in a camera demonstrator including a 1.5&mu;m laser illuminator for field trials to demonstrate long range identification. The paper will present the latest performance results including field trials of MCT based eSWIR modules and sights for imaging applications.
Simultaneous CBF and [HbO] Resting-State Functional Connectivity in Mice (2014)

The interpretation of altered functional connectivity (fc) in disease is potentially complicated by concurrent alterations in neurovascular coupling. Creating maps of fc from spontaneous blood will potentially help clarify signatures of dysfunction.
Supervised Classification of Sound Speed Profiles via Dictionary Learning (2022)

Abstract The presence of internal waves (IWs) in the ocean alters the isotropic properties of sound speed profiles (SSPs) in the water column. Changes in the SSPs affect underwater acoustics since most of the energy is dissipated into the seabed due to the downward refraction of sound waves. In consequence, variations in the SSP must be considered when modeling acoustic propagation in the ocean. Empirical orthogonal functions (EOFs) are regularly employed to model and represent SSPs using a linear combination of basis functions that capture the sound speed variability. A different approach is to use dictionary learning to obtain a learned dictionary (LD) that generates a nonorthogonal set of basis functions (atoms) that generate a better sparse representation. In this paper, the performance of EOFs and LDs are evaluated for sparse representation of SSPs affected by the passing of IWs. In addition, an LD-based supervised framework is presented for SSP classification and is compared with classical learning models. The algorithms presented in this work are trained and tested on data collected from the Shallow Water Experiment 2006. Results show that LDs yield lower reconstruction error than EOFs when using the same number of bases. In addition, overcomplete LDs are demonstrated to be a robust method to classify SSPs during low, medium, and high IW activity, reporting accuracy that is comparable to and sometimes higher than that of standard supervised classification methods.