gebhart/patrepeval huggingface dataset:
Effects of Translational and Gripping Force Feedback are Decoupled in a 4-Degree-of-Freedom Telemanipulator (2007)

Many high-degree-of-freedom haptic devices and teleoperator systems either do not have grippers or do not provide force feedback in the gripper degree of freedom (DOF). The purpose of this work is to determine the effect of gripper force feedback in relation to Cartesian (translational) force feedback on the execution of telemanipulation tasks. We developed a system for adding an additional DOF of grip force feedback on a 3-DOF Phantom haptic device master, as well as 6-DOF force/torque sensing on each "finger" of a coupled gripper on a Phantom haptic device slave. The internal (grip) and external (translational) forces were measured as users performed a soft peg-in-hole task with various DOFs of force feedback: (1) full force feedback, (2) translational force feedback only, (3) grip force feedback only, and (4) no force feedback. Results show that the level of force applied in the translational and gripping DOFs are decoupled for a 3-DOF telemanipulator with added grip force feedback. This is likely due to the decoupled dynamics of internal and external hand forces
An optimized method for the isolation and identification of membrane proteins (2003)

The purpose of this study was to develop a protocol suitable for membrane protein extraction from limited starting material and to identify appropriate conditions for two-dimensional (2-D) gel electrophoresis. We used A549 cells, a human alveolar type II cell line, and evaluated three protein extraction methods based on different separation principles, namely protein solubility, detergent-based and density-based organelle separation. Detergent-based extraction achieved the highest yield with 14.64% +/- 2.35 membrane proteins but sequential extraction with 7.35% +/- 0.78 yield and centrifugal extraction with 4.1% +/- 0.54 yield produced the purest fractionation of membrane proteins. Only the sequential and the detergent-based extraction proved suitable for small volumes of starting material. We identified annexin I + II, electron transfer flavoprotein beta-chain, H(+)-transporting ATP synthase, mitofilin and protein disulfide isomerase A3 as membrane and cytokeratin 8 + 18, actin and others as soluble proteins using matrix assisted laser desorption/ionization-time of flight (MALDI-TOF) analysis and started to map the A549 cell proteome. Our data suggest that membrane proteins can be extracted efficiently from small samples using a simple sequential protein extraction method. They can be separated and identified successfully using optimized conditions in 2-D gel electrophoresis. The presented methods will be useful for further investigations of membrane proteins of alveolar and bronchial carcinomas.
On and off state hot carrier reliability in junctionless high-K MG gate-all-around nanowires (2015)

Hot carrier (HC) reliability is investigated at `on' and `off' state stress conditions in junctionless (JL) gate-all-around HK/MG nanowires. We discuss the reason of improved HC reliability in JL nanowire compared to the inversion-mode (IM) nanowire at `on' state stress condition. Then we present the impact of `off' state stress in the JL nanowire, considering that a high gate oxide field is applied at the `off' state. Additionally, the improved sub-threshold swing (SS) after HC stress in some JL nanowires is discussed.
Rapid Reduction of HbA1c and Early Worsening of Diabetic Retinopathy: A Real-world Population-Based Study in Subjects With Type 2 Diabetes (2023)

Our results suggest that the rapid reduction of HbA1c is not associated with progression of mild or moderate NPDR.
Prostaglandins Reduce the Contractile Responses to Noradrenaline and Angiotensin II in Canine Femoral Arteries After But Not Before Chronic Inhibition of Nitric Oxide Synthesis (1997)

This study was designed to compare the contractile responses to graded concentrations of noradrenaline (1 nM-100 microM) and angiotensin II (0.1-100 nM) of femoral arteries isolated from normal control dogs and from dogs after long-term inhibition of nitric oxide (NO) by N(omega)-nitro-L-arginine (L-NNA; 20 mg/kg/day for 7 days). Maximal contraction to noradrenaline was similar in rings obtained from control and L-NNA-treated dogs. In the latter, however, sensitivity to noradrenaline was reduced compared with control rings, whether the endothelium was present [50% effective concentration (EC50) = 6.04 +/- 0.06 vs. 6.37 +/- 0.08; p < 0.01] or absent (EC50 = 6.00 +/- 0.11 vs. 6.45 +/- 0.05; p < 0.01). Indomethacin reversed this hyporesponsiveness to noradrenaline in arteries obtained from L-NNA-treated dogs but had no effect in rings isolated from control dogs. An almost complete inhibition of the contractile response to angiotensin II, also reversed by indomethacin, was observed in arteries taken from L-NNA-treated dogs both in the presence and in the absence of endothelium. These results suggest that the cyclooxygenase pathway might be upregulated in the smooth muscle cells of canine femoral arteries after long-term inhibition of NO synthesis and that relaxing prostanoids mediate the hypocontractile response of these arteries to both noradrenaline and angiotensin II.
The nucleotide sequence surrounding the replication terminus of R6K. (1981)

The replication terminus of the plasmid R6K has been cloned into the single-stranded DNA phage vector M13mp5 and also into the plasmid vectors pBR313 and PBR322. By using single-stranded DNA templates prepared from the recombinant DNA clones, the sequence of 215 base pairs of DNA containing the replication terminus has been determined. The DNA sequence of the region of the terminus does not contain any 2-fold rotational symmetry. Therefore, folding of the DNA at the region of the terminus is unlikely to be a cause for replication termination. Interaction of a host-specified protein(s) with the sequence of the replication terminus is probably the basis of the mechanism of replicaion termination.
Screening and Evaluation of Different Wet Cleaning Solutions for Post Etch Residue Removal in BEOL Applications (2009)

Two types of wet cleaning solutions were screened for post etch residue removal in back end of line applications: aqueous acid chemistries and organic solvents. Their compatibility with plasma damaged low-k materials and their polymer removal efficiency were checked on blanket low-k layers and single damascene layers, respectively. Aqueous acid chemistries under study showed either to be compatible with plasma damaged low k material but had poor polymer removal efficiency, or showed good polymer removal but also removal of the plasma damaged low-k. A correlation between the damaged low-k and the amount of etching additive in aqueous acid chemistry could be established. Initial tests with organic solvents demonstrated that they were compatible with the damage low-k layer. Concerning polymer removal, some partial dissolution of polymers was observed for the first time. Furthermore, the cleaning performance of organic solvents, and hence the electrical performance, can be improved by applying megasonic power during the clean process.
How Crystallite Size Controls the Reaction Path in Nonaqueous Metal Ion Batteries: The Example of Sodium Bismuth Alloying (2016)

Crystallite size effects can influence the performance of battery materials by making the structural chemistry deviate from what is predicted by the equilibrium phase diagram. The implications of this are profound: the properties of many battery materials should be reassessed. Sodium ion battery anodes made from nanocrystalline bismuth form different phases during electrochemical cycling compared to anodes with larger crystallites. This is due to the formation of a metastable cubic polymorph of Na3Bi on the crystallite surfaces. The structural differences (weaker Na–Bi bonds, different coordination of Na to Bi) between the metastable cubic Na3Bi phase found in the nanocrystals and the hexagonal equilibrium polymorph which dominates the larger crystallites offer an explanation for the improvements in cycling behavior observed for the nanostructured anode.
Thermal Analysis Safety Margins Using ABAQUS for the MP-2 Experiment in the Advanced Test Reactor (2018)

The Mini-Plate 2 (MP-2) irradiation test is a fueled experiment designed for irradiation in multiple test locations in the Advanced Test Reactor (ATR). MP-2 is considered a non-instrumented drop-in test where small aluminum-clad fuel plate samples are cooled directly by the ATR Primary Coolant System (PCS) water. The MP-2 fuel plate experiment will be irradiated in several different irradiation locations of the ATR. This fueled experiment contains aluminum-clad fuel mini plates consisting of monolithic U-Mo. Four different types of fuel plates were analyzed. A thermal analysis has been performed on the MP-2 experiment to be irradiated in the ATR at Idaho National Laboratory (INL). A new technique for calculating Departure from Nucleate Boiling Ratio (DNBR) and Flow Instability Ratio (FIR) using the commercial finite element and heat transfer code ABAQUS is demonstrated. This new technique calculates DNBR for the fuel plate surfaces and FIR for all water components for each finite element surface and node. Pressure drop data is fed into the calculations in order to geometrically calculate the water saturation temperature. Results from the DNBR and FIR calculations are displayed with the ABAQUS post processor named Viewer. By calculating these parameters at each location in the finite element model, conservatism is replaced with accuracy. This allows for a greater margin for the thermal hydraulic safety parameters.
Preparation of [ 18 F]-NHC-BF 3 conjugates and their applications in PET imaging (2020)

[ 18 F]-NHC-BF 3 functionalized bioactive molecules can be successfully synthesized by 18 F– 19 F isotopic exchange in one labelling step affording highly stable PET probes which can visualize targeted tumours in mice.
Superconducting NbN for Strong Magnetic Field Applications: Impact of the Thin Films Intrinsic Disorder (2022)

The research on superconducting circuits for quantum information technologies progressively extends from the academic world towards the industry. Material sciences therefore become an essential lever for the development of technologies based on such circuits as they allow finding industry-compatible routes of improvements. In this context, we propose a study on the behavior of the niobium nitride (NbN), one of the most commonly used material for these devices, when exposed to strong magnetic fields. To this aim, the properties of NbN layers with the same composition but different microstructures, tuned by changing the deposition method, are compared. This study aims to establish interdependencies between the microstructure of the material and its behavior once exposed to a magnetic field. X-ray diffraction and Hall-effect characterizations are used to assess that the microstructure is significantly modified by the choice of the deposition technique. Pushing further these investigations also allowed to quantify and compare the level of disorder in both cases by extracting the Ioffe-regel and the Ginzburg-Landau parameters from characterizations of the superconducting transition temperature for several magnetic field amplitudes. This was used to conclude that in highly disordered NbN layers, the microstructure heterogeneities are responsible for a strong electron localization allowing to significantly enhance the resilience of their superconducting state under strong magnetic fields.
Frequency dependent magnetization of superconductor strip (2011)

The frequency dependence of magnetic ac loss of thin superconductor strip subjected to an ac magnetic field perpendicular to the surface of the strip is investigated by incorporating a flux creep model into the critical state model of Brandt and Indenbom. It is found that the reduced ac loss exhibits a maximum value at a frequency f m , which is a rapidly varying function of the applied ac magnetic field. At low magnetic field, f m becomes zero, and ac loss decreases with frequency as a power law (∼ f − 2/ n ). Whereas at high magnetic field f m becomes infinite and ac loss increases with frequency, still following the power law (∼ f 1/ n ). The analytical results are substantiated with experimental data and the results of a 2D finite element simulation.
Dynamic Figure Eight Loop Structure of <i>meso</i>-Tetraaryl[32]octaphyrins(1.0.1.0.1.0.1.0) (2009)

3,3'-Diethyl substituents of the 2,2'-bipyrrole components in meso-tetraaryl[32]octaphyrins(1.0.1.0.1.0.1.0) affect the cavity shape through CH/pi interactions and remarkably accelerate syn-anti conformational change of the 2,2'-bipyrrole components leading to helicity change in the figure eight loop of [32]octaphyrins.
The effects on hematopoiesis of recombinant stem cell factor (ligand for c-kit) administered in vivo to mice either alone or in combination with granulocyte colony-stimulating factor (1991)

Stem cell factor (SCF) is the ligand for the receptor encoded by the c- kit proto-oncogene. Mutations of either c-kit or the SCF gene are responsible for the defects of W and SI mutant mice, which both suffer a macrocytic anemia, the former associated with defective stem cells and the latter with a defective hematopoietic microenvironment. PEGylated recombinant rat SCF was administered to normal or splenectomized mice for up to 21 days. SCF was found to be a modest stimulator of peripheral blood neutrophil numbers in both groups of animals. The peak in neutrophil numbers was higher and occurred earlier in splenectomized mice. Bone marrow and spleen cellularity changed little during treatment but the content of interleukin-3-responsive progenitor cells and spleen colony-forming cells (CFU-S) reached very high levels, particularly in the spleen. Using recombinant human granulocyte colony-stimulating factor (rhG-CSF), we have shown that SCF induces a greater than additive increase in both blood neutrophils and blood-borne CFU-S. This synergy was seen throughout the dose range and may indicate a clinical role for SCF either alone or in augmenting the activity of G-CSF upon blood neutrophils and transplantable stem cells.
PharML.Bind: Pharmacologic Machine Learning for Protein-Ligand\n Interactions (2019)

Is it feasible to create an analysis paradigm that can analyze and then\naccurately and quickly predict known drugs from experimental data? PharML.Bind\nis a machine learning toolkit which is able to accomplish this feat. Utilizing\ndeep neural networks and big data, PharML.Bind correlates\nexperimentally-derived drug affinities and protein-ligand X-ray structures to\ncreate novel predictions. The utility of PharML.Bind is in its application as a\nrapid, accurate, and robust prediction platform for discovery and personalized\nmedicine. This paper demonstrates that graph neural networks (GNNs) can be\ntrained to screen hundreds of thousands of compounds against thousands of\ntargets in minutes, a vastly shorter time than previous approaches. This\nmanuscript presents results from training and testing using the entirety of\nBindingDB after cleaning; this includes a test set with 19,708 X-ray structures\nand 247,633 drugs, leading to 2,708,151 unique protein-ligand pairings.\nPharML.Bind achieves a prodigious 98.3% accuracy on this test set in under 25\nminutes. PharML.Bind is premised on the following key principles: 1) speed and\na high enrichment factor per unit compute time, provided by high-quality\ntraining data combined with a novel GNN architecture and use of\nhigh-performance computing resources, 2) the ability to generalize to proteins\nand drugs outside of the training set, including those with unknown active\nsites, through the use of an active-site-agnostic GNN mapping, and 3) the\nability to be easily integrated as a component of increasingly-complex\nprediction and analysis pipelines. PharML.Bind represents a timely and\npractical approach to leverage the power of machine learning to efficiently\nanalyze and predict drug action on any practical scale and will provide utility\nin a variety of discovery and medical applications.\n
A simplified integrated framework for predicting the economic impacts of feedstock variations in a catalytic fast pyrolysis conversion process (2021)

Abstract Feedstock attributes of lignocellulosic biomass, such as particle size, compositional makeup, and moisture content, can vary substantially even within pre‐processed materials and have a significant effect on conversion in fast pyrolysis‐based processes. However, the economic impacts of these attributes are not well understood. To address this, biomass deconstruction phenomena captured with a versatile particle‐scale simulation were linked to techno‐economic impacts via reduced‐order models. Parametric analysis of the particle‐scale model, which was validated using literature data, was used in combination with multiple linear regression models to develop correlations between feedstock attributes and yields of pyrolysis oil, gas, and char. Yields were then correlated with the minimum fuel selling price (MFSP) using a techno‐economic model, bridging the gap between physics‐based biomass conversion simulations and predictions of MFSP for a catalytic fast‐pyrolysis process. Empirical correlations derived from the literature regarding the impact of mineral matter (ash) on oil yield were also considered. The model correlations deployed in the integrated framework capture the impacts of variation in feedstock attributes on the MFSP. Variations in ash were shown to have the biggest impact, varying MFSP by −13%/+22% due to catalytic effects and lower relative amounts of convertible lignocellulosic material. It was also found that, if ash can be controlled to low levels, the increased extractives in forest residues can help compensate for some yield losses associated with increased ash. Other inputs considered (particle size, moisture content, and reactor temperature) had relatively negligible effects on process economics within the ranges analyzed considering particle‐scale effects alone. © 2021 Society of Chemical Industry and John Wiley &amp; Sons, Ltd
A wideband low noise SiGe medium power amplifier for X-Band Phased Array applications (2016)

This paper presents a Medium Power Amplifier (MPA) for X-Band Phased Array RADAR applications in 0.25μm SiGe technology. The MPA is designed such that it achieves high output power and low noise simultaneously that enables its use in Transmitter/Receiver (T/R) core module as a Low Noise Amplifier (LNA). The MPA achieves 23.6dB peak gain and 17.3dB maximum output power at 10GHz with a power consumption of 190mW. Its input and output is matched in a 7 GHz of bandwidth, while its mean Noise Figure (NF) is about 3dB throughout the defined bandwidth. According to authors' knowledge, this work presents state-of-the-art wideband MPA performances in literature, with 7GHz of operational bandwidth and 17.3dBm output power.
Hand Grenade on a Hot Day (2011)

I<br> Graffiti <br>Crown of Thorns<br> Evening on the Diamond <br>Form of My Father<br> Blood on the Chopping Block<br> Going Downstream II<br> Hand Grenade on a Hot Day<br> Up in Smoke <br>The Smell of Shit<br> Do You Think I'm Easy?<br> A Moment of Recognition<br> If Only<br> Die Trying III<br> The Barber<br> Childhood Forté<br> The Physics of Violence<br> Eyes Wide Open<br> What's It Worth?<br> Someone Else's House<br> It's Not Alright<br> Addicted to Your Memory <br>Misery<br> The Bones Beneath the Skin
<i>SCARB2</i> mutations in progressive myoclonus epilepsy (PME) without renal failure (2009)

Mutations in SCARB2 are an important cause of hitherto unsolved cases of PME resembling ULD at onset. SCARB2 should be evaluated even in the absence of renal involvement. Onset is in teenage or young adult life. Molecular diagnosis is important for counseling the patient and family, particularly as the prognosis is worse than classical ULD.
Heart Regeneration: Opportunities and Challenges for Drug Discovery with Novel Chemical and Therapeutic Methods or Agents (2014)

Following a heart attack, more than a billion cardiac muscle cells (cardiomyocytes) can be killed, leading to heart failure and sudden death. Much research in this area is now focused on the regeneration of heart tissue through differentiation of stem cells, proliferation of existing cardiomyocytes and cardiac progenitor cells, and reprogramming of fibroblasts into cardiomyocytes. Different chemical modalities (i.e. methods or agents), ranging from small molecules and RNA approaches (including both microRNA and anti-microRNA) to modified peptides and proteins, are showing potential to meet this medical need. In this Review, we outline the recent advances in these areas and describe both the modality and progress, including novel screening strategies to identify hits, and the upcoming challenges and opportunities to develop these hits into pharmaceuticals, at which chemistry plays a key role.
ChemInform Abstract: Radiation Chemistry of Organic Liquids: Saturated Hydrocarbons. (2002)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Use of x-ray optical systems in a small diffractometer (1998)

The use of Kumakhov halflenses in a small diffractometers with position-sensitive detector for the investigation of stress-deformation state is considered. The possibility of obtaining the system of parallel beam with a small angular divergence allows to estimate the state of stress- deformation in a various sections of object under investigation, owing to drawing near or moving away x-ray tube connected with the halflens. It is shown, that the new method should be very interesting for determination of the reliability of a real articles.
Supplementary Fig. S4 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells (2023)

Supplementary Fig. S4 from Stromal-mediated protection of tyrosine kinase inhibitor-treated BCR-ABL-expressing leukemia cells
301 Morphometric Analysis of Pancreatic Islet Cells: Two Cases of Nesidioblastosis Following Sleeve Gastrectomy (2018)

Nesidioblastosis is a rare cause of non-insulinoma pancreatogenous hypoglycemia most commonly found in children. Idiopathic adult-onset cases have been described in the literature, but most recently adult onset nesidioblastosis has been described following gastric bypass surgery. At our institution, we have two such cases. Morphometric analysis of these two cases and two age- and gender-matched controls was performed. H&E sections were scanned using a whole slide scanner, and the outlines of the islets were traced using manual inspection. Refinement to the islet surface areas was performed using image-processing techniques. Analysis of islet area and ratio of endocrine to exocrine surface area was performed. The mean islet area of the first nesidioblastosis case was 2.0777 x 104, while the normal control had a mean area of 8.6457 x 103. The second case had a mean islet area of 1.7323 x 104, and the normal control had a mean islet area of 8.7521 x 103. Thus, on average, the ratio of endocrine to exocrine area was observed to be larger by 3- to 15-fold in nesidioblastosis. A trend towards alteration in nuclear size and density was also observed which would require further study in a larger cohort. In summary, using morphometric analysis, hyperplasia of the islet cells is observed to occur in a subset of adult individuals after sleeve gastrectomy. This suggests possible alterations in growth hormone production, as reported in pediatric nesidioblastosis, requiring further study in adults post gastric bypass surgery subjects.