gebhart/patrepeval huggingface dataset:
Development of Novel Amphiphilic Pyrazole‐<i>g</i>‐PolyGlycidyl methacrylate‐Based Polymers with Potential Antimicrobial Activity (2016)

Abstract In this work, novel amphiphilic pyrazole‐g‐polyglycidyl methacrylate‐based polymers have been prepared, characterized, and evaluated for antimicrobial activity. The pyrazole derivative (4‐(4‐chlorophenyl) azo‐1 H ‐pyrazole‐3, 5‐diamine) is grafted to the epoxy rings of polyglycidyl methacrylate and poly (glycidyl methacrylate‐co‐methyl methacrylate) copolymers. The structure verification was performed using FT ‐ IR and TGA analyses. Finally, the novel pyrazole‐g‐polyacrylates copolymers were tested against different gram‐positive and gram‐negative bacteria strains. All the derivatives show antimicrobial activity against both gram‐positive and gram‐negative bacteria strains with varying degrees. Pyrazole‐g‐PolyGlycidyl methacrylate shows the most potential antibacterial activities followed by pyrazole‐g‐poly (glycidyl methacrylates‐co‐methyl methacrylate) copolymers where the polymethyl methacrylate content show a determining effect. Minimum inhibition and biocide concentrations were determined and compared with gentamicin and ketoconazole antibiotics.
O computador e o ensino da Matemática: Um processo de inovação, investigação e formação de professores (1991)

O computador, um simbolo por excelencia do progresso cientifico e tecnologico que se desenvolve a um ritmo cada vez mais acelerado, tem desde a sua origem uma relacao muito especial com a matematica, influenciando hoje muitos aspectos do seu desenvolvimento. Podera vir a ter um papel igualmente significativo no que respeita ao ensino desta disciplina? Este trabalho da conta de actividades e experiencias que a este respeito desde 1985 vem Portugal. Assim, num primeiro momento, serao discutidas as relacoes entre o computador e a matematica. Seguidamente, sera feita uma breve apresentacao do Projecto MINERVA, criado com o objetivo de introduzir nas escolas as Novas Tecnologias da Informacao. Em e trabalhos de investigacao realizados e aprensentadas as Linhas mestras do programa de formacao. Depois, a luz desta experiencia, analisam-se as principais oportunidades que o computador oferece para utilizacao educativa, discutindo-se as respectivas potencialidades e condicoes de implementacao, e finalmente, esbocam-se algumas conclusoes.
Preparation of Stereoregular Isotactic Poly(mandelic acid) through Organocatalytic Ring‐Opening Polymerization of a Cyclic <i>O</i>‐Carboxyanhydride (2014)

Poly(mandelic acid) (PMA) is an aryl analogue of poly(lactic acid) (PLA) and a biodegradable analogue of polystyrene. The preparation of stereoregular PMA was realized using a pyridine/mandelic acid adduct (Py⋅MA) as an organocatalyst for the ring-opening polymerization (ROP) of the cyclic O-carboxyanhydride (manOCA). Polymers with a narrow polydispersity index and excellent molecular-weight control were prepared at ambient temperature. These highly isotactic chiral polymers exhibit an enhancement of the glass-transition temperature (T(g)) of 15 °C compared to the racemic polymer, suggesting potential future application as high-performance commodity and biomedical materials.
Selectively Enhanced Cellular Signaling by G <sub>i</sub> Proteins in Essential Hypertension (1996)

Recent studies have shown an enhanced signaling capacity of receptors coupled to pertussis toxin (PTX)-sensitive guanine nucleotide-binding proteins (G proteins) in immortalized B lymphoblasts from patients with essential hypertension. In the present study, we analyzed (1) whether such alterations would also be expressed in nontransformed cells of these individuals and (2) whether other G protein-mediated signaling pathways were also altered. Therefore, we established primary cultures of skin fibroblasts from previously characterized normotensive and hypertensive individuals (NT and HT cells, respectively). [Ca2+]i rises induced by lyso-phosphatidic acid (LPA), thrombin, and sphingosine-1-phosphate as well as the formation of inositol 1,4,5-trisphosphate and [3H]thymidine incorporation evoked by LPA were PTX sensitive and enhanced twofold in HT fibroblasts. In contrast, cellular responses induced by bradykinin, endothelin-1, and angiotensin II (all PTX insensitive) were similar in NT and HT cells. Formation of cAMP induced by stimulation of Gs with isoproterenol was identical in NT and HT cells. Western blot analysis yielded no evidence for an overexpression of G alpha i2, G alpha i3, G beta 2, and G beta 4. Furthermore, sequencing of cDNAs encoding for the ubiquitously expressed PTX-sensitive G protein subunits G alpha i2, G alpha i3, G beta 1, and G beta 2 from NT and HT cell lines yielded no evidence for mutations in these genes. Although the molecular mechanisms remain to be defined, these data support the concept of a selective enhancement of signal transduction via PTX-sensitive G proteins in essential hypertension.
Shoulder proprioception: latent muscle reaction times (1999)

These results suggest that the rotator cuff muscles of trained throwers may be downregulated in response to sudden internal rotation perturbation. Although these adaptations would enable greater internal rotation velocities during overhead throwing, they may also contribute to glenohumeral joint pathology. The identification of changes in rotator cuff LMRT in response to sudden internal rotation perturbation suggests an area of acquired neuromuscular imbalance warranting consideration by those involved in the rehabilitation and conditioning of the overhead throwing athlete.
Type II hereditary angioneurotic edema that may result from a single nucleotide change in the codon for alanine-436 in the C1 inhibitor gene. (1990)

Identical single-base changes in the C1 inhibitor gene that may result in dysfunctional inhibitor proteins are described in two different families with type II hereditary angioneurotic edema. Initially, a restriction fragment length polymorphism was defined that resulted from loss of a Pst I site within exon VIII, which encodes the region containing the reactive center. Exon VIII from the normal and abnormal allelles was amplified by the polymerase chain reaction. Amplified DNA product was cloned into plasmid pUC18; clones representing normal and mutant allelles were distinguished by the presence and absence, respectively, of the Pst I restriction site. DNA sequence analysis revealed a G----A mutation in the codon for alanine-436, which would result in replacement with a threonine residue. This position is nine amino acid residues amino-terminal to the reactive-center arginylthreonine peptide bond. In contrast, previously defined mutations in type II hereditary angioneurotic edema result in replacement of the reactive-center arginine.
New Write Shift Compensation Method Modified for Optical Disk Systems to Which Partial Response Maximum Likelihood (PRML) Detection Is Applied (2003)

A new write shift compensation method is proposed in this paper. The method is suitable for an optical disk system which adopts partial response maximum likelihood (PRML) detection, and it can optimize adaptive controlled writing pulses even under severe inter-symbol interference (ISI) conditions to reduce detection errors. This advantage is attributable to the use of the Euclidean distance as the estimation index of the mark edge shift error. The effect is confirmed by the experimental results for blue laser systems.
Stabilizing Polymer–Lithium Interface in a Rechargeable Solid Battery (2019)

Abstract Solid polymer electrolytes (SPEs) are promising candidates for developing high‐energy‐density Li metal batteries due to their flexible processability. However, the low mechanical strength as well as the inferior interfacial regulation of ions between SPEs and Li metal anode limit the suppress ion of Li dendrites and destabilize the Li anode. To meet these challenges, interfacial engineering aiming to homogenize the distribution of Li + /electron accompanied with enhanced mechanical strength by Mg 3 N 2 layer decorating polyethylene oxide is demonstrated. The intermediary Mg 3 N 2 in situ transforms to a mixed ion/electron conducting interlayer consisting of a fast ionic conductor Li 3 N and a benign electronic conductor Mg metal, which can buffer the Li + concentration gradient and level the nonuniform electric current distribution during cycling, as demonstrated by a COMSOL Multiphysics simulation. These characteristics endow the solid full cell with a dendrite‐free Li anode and enhanced cycling stability and kinetics. The innovative interface design will accelerate the commercial application of high‐energy‐density solid batteries.
Observation of the Spin Hall Effect of Light via Weak Measurements (2008)

We have detected a spin-dependent displacement perpendicular to the refractive index gradient for photons passing through an air-glass interface. The effect is the photonic version of the spin Hall effect in electronic systems, indicating the universality of the effect for particles of different nature. Treating the effect as a weak measurement of the spin projection of the photons, we used a preselection and postselection technique on the spin state to enhance the original displacement by nearly four orders of magnitude, attaining sensitivity to displacements of approximately 1 angstrom. The spin Hall effect can be used for manipulating photonic angular momentum states, and the measurement technique holds promise for precision metrology.
« L’implantation de pharmacies saisie par le droit du marché : la lointaine proximité du droit de l’Union. À propos de l’affaire Susanne Sokoll », in Chronique Droit européen du marché intérieur / dir. Éric Carpano (2012)

International audience
Abstract TP226: Impact Of Apolipoprotein A-i In The Attenuation Of Stroke And Stroke Symptoms (2023)

Apolipoprotein AI is the major protein component of high-density lipoprotein (HDL) particles in plasma. Inflammatory cytokines such as TNF and IL-1β repress the production of ApoA-I from hepatocytes and increase the expression of serum amyloid A (SAA), which becomes the major protein component of HDL in this context. Consequently, lipid-poor ApoA-I is rapidly catabolized in the liver and the kidney. These findings could be meaningful if ApoA-I, in addition to its proimmune features, had anti-inflammatory potential. In this way, removal of ApoA-I could intensify the inflammatory response, resulting in a more robust effect. Recent studies have suggested that serum apolipoprotein A1 maybe a predictor and prognostic biomarker in acute ischemic stroke in humans. To understand the impact of ApoA-I in stroke, we have begun to analyze the role of ApoA-I in mouse models of stroke. Mice with reduced or deficient in ApoA-I and subjected to ischemia and reperfusion injury or permanent ischemia, had increased inflammatory responses, larger infarct volumes, and poorer outcomes than wildtype mice. Mice transgenic for the human ApoA-I gene showed a level of protection not seen in the wildtype mice when given an ischemic injury. Administration of AAV human ApoA-I increased HDL levels in deficient mice and provided protection against ischemic injury. Additionally, drugs to enhance ApoA-I expression showed protection against strokes in the mouse models. These studies, along with subsequent investigations will provide a better understanding and potential therapeutic approaches in the field of stroke.
Molecular Modeling:  Basic Principles and Applications. 2nd Edition By Hans-Dieter Höltje, Wolfgang Sippl, Didier Rognan, and Gerd Folkers. Wiley-VCH, Weinheim, Germany. 2003. xii + 228 pp. 17 × 24 cm. ISBN 3527305890 (Paperback). $50.00. (2004)

ADVERTISEMENT RETURN TO ISSUEPREVBook ReviewNEXTMolecular Modeling: Basic Principles and Applications. 2nd Edition By Hans-Dieter Höltje, Wolfgang Sippl, Didier Rognan, and Gerd Folkers. Wiley-VCH, Weinheim, Germany. 2003. xii + 228 pp. 17 × 24 cm. ISBN 3527305890 (Paperback). $50.00.Glen E. KelloggView Author Information School of Pharmacy Virginia Commonwealth University Richmond, Virginia 23298-0540Cite this: J. Med. Chem. 2004, 47, 18, 4631Publication Date (Web):July 24, 2004Publication History Published online24 July 2004Published inissue 1 August 2004https://pubs.acs.org/doi/10.1021/jm040111zhttps://doi.org/10.1021/jm040111zbook-reviewACS PublicationsCopyright © 2004 American Chemical SocietyRequest reuse permissionsArticle Views363Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Drug discovery,Homology,Molecular modeling,Peptides and proteins,Structural bioinformatics Get e-Alerts
Register file soft error recovery (2023)

Register file soft error recovery including a system that includes a first register file and a second register file that mirrors the first register file. The system also includes an arithmetic pipeline for receiving data read from the first register file, and error detection circuitry to detect whether the data read from the first register file includes corrupted data. The system further includes error recovery circuitry to insert an error recovery instruction into the arithmetic pipeline in response to detecting the corrupted data. The inserted error recovery instruction replaces the corrupted data in the first register file with a copy of the data from the second register file.
Enhancement of spontaneous and stimulated emission of a rhodamine 6G dye by an Ag aggregate (2006)

We have demonstrated that by adding the solution of aggregated silver nanoparticles to the solution of rhodamine $6\mathrm{G}\phantom{\rule{0.3em}{0ex}}\mathrm{dye}$, one can enhance the efficiency of spontaneous and stimulated emission. We attribute an increase of the spontaneous emission intensity of dye to the increase of the absorption efficiency caused by the field enhancements in metallic nanostructures associated with surface plasmons. The enhancement of the stimulated emission of dye, which has the same nature as the enhancement of absorption, was observed in the pump-probe and laser experiments.
Analytical validation and quality control/quality assurance practices for improved rigor and reproducibility of biochemical assays in orthopaedic research (2022)

Orthopaedic research, and biomedical research in general, has made enormous strides to develop treatments for conditions long thought to be inevitable or untreatable; however, there is growing concern about the quality of published research. Considerable efforts have been made to improve overall research quality, integrity, and rigor, including meaningful proposals focused on transparency of reporting, appropriate use of statistics, and reporting of negative results. However, we believe that there is another key component to rigor and reproducibility that is not discussed sufficiently-analytical validation and quality control (QC). In this commentary, we discuss QC and method validation principles and practices that are systematically applied in the clinical laboratory setting to verify and monitor the analytical performance of quantitative assays, and the utility of applying similar practices to biochemical assays in the orthopaedic research setting. This commentary includes (1) recommendations for validation and QC practices, including examples of assay performance limitations uncovered by validation experiments performed in our laboratory, and (2) a description of an ongoing QC program developed to monitor the ongoing performance of commonly used assays in our lab. We hope that this commentary and the examples presented here will be thought-provoking and inspire further discussion and adaptation of analytical validation and QC procedures to advance our shared pursuit of high-quality, rigorous, and reproducible orthopaedic research.
Photolithographic Structuring of Ordered Silicon Micropillar Electrodes for Lithium-Ion Batteries and Electrochemical Performance (2023)

Ordered and vertically oriented silicon (Si) micropillar structures, when optimally designed, can accommodate the lithiation-induced volumetric expansion that is limiting the implementation of Si as negative electrodes in Li-ion batteries. As there is not much work in this area, this study is focused on evaluating systematically the potential of Si micropillar electrodes prepared by photolithographic structuring of Si. The specific objective is to determine the effect of micropillar length and the free space around the pillars on the electrochemical performance of the electrode. The Si micropillar electrode with the pillar length of 14 μm showed a high specific capacity (2600 mAh/g) and a high areal capacity (3 mAh/cm2), which were stable for over 100 cycles. However, there was significant capacity degradation in 32 and 48 μm-long Si pillar electrodes due to cracking and electrode damage during cycling. In the 32 μm Si micropillar electrode, a small change in porosity from 69 to 86% caused a substantial increase in specific capacity from 1400 to 2000 mAh/g over 100 cycles, with the areal capacity decreasing from 3 to 2 mAh/cm2. The findings also show the directions for further work for the optimization of Si micropillar electrodes.
T7 RNA polymerase does not interact with the 5'-phosphate of the initiating nucleotide (1989)

The study of transcription kinetics by T7 RNA polymerase is facilitated by the small size of its promoter, allowing the use of synthetic oligonucleotide templates with carefully defined sequences. We have previously used this approach to measure Michaelis-Menten steady-state kinetics for production of the five-base runoff transcript GGACU. In particular, Km for the interaction between enzyme and template under saturating levels of all four nucleotide triphosphates was shown to be approximately 0.02 microM. We now show that the corresponding Km and Vmax for initiation on a similar template coding for the runoff transcript GACU are the same as for the earlier study (Km = 0.02 microM; kcat = 40-50 min-1). This new template allows the measurement Km for association of the initial nucleotide GTP with enzyme or with the enzyme-DNA complex. The results show that KGTPm (0.60 mM) is somewhat higher than earlier approximations of Km for addition of elongating GTP during the later phase of processive elongation. As expected, the (initiating) Km for the GTP analogue ITP (KITPm) is increased (by about 2-fold), presumably as a result of weakened Watson-Crick base pairing. However, comparison of Km values for the GTP analogues GMP and guanosine shows little effect on substitution of the 5'-triphosphate by monophosphate or by a hydroxyl, respectively. This result suggests that a single active site has been evolutionarily adapted to accept from the 5' end of a waiting nucleotide both a 5'-triphosphate at initiation and a 5'-monophosphate ester (RNA) during elongation.(ABSTRACT TRUNCATED AT 250 WORDS)
DyLink2Vec: Effective Feature Representation for Link Prediction in Dynamic Networks (2018)

The temporal dynamics of a complex system such as a social network or a communication network can be studied by understanding the patterns of link appearance and disappearance over time. A critical task along this understanding is to predict the link state of the network at a future time given a collection of link states at earlier time points. In existing literature, this task is known as link prediction in dynamic networks. Solving this task is more difficult than its counterpart in static networks because an effective feature representation of node-pair instances for the case of dynamic network is hard to obtain. To overcome this problem, we propose a novel method for metric embedding of node-pair instances of a dynamic network. The proposed method models the metric embedding task as an optimal coding problem where the objective is to minimize the reconstruction error, and it solves this optimization task using a gradient descent method. We validate the effectiveness of the learned feature representation by utilizing it for link prediction in various real-life dynamic networks. Specifically, we show that our proposed link prediction model, which uses the extracted feature representation for the training instances, outperforms several existing methods that use well-known link prediction features.
Mechanism of the interaction of n,.pi.* excited alkanones with electron-rich ethylenes (1975)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMechanism of the interaction of n,.pi.* excited alkanones with electron-rich ethylenesNeil E. Schore and Nicholas J. TurroCite this: J. Am. Chem. Soc. 1975, 97, 9, 2482–2488Publication Date (Print):April 1, 1975Publication History Published online1 May 2002Published inissue 1 April 1975https://pubs.acs.org/doi/10.1021/ja00842a027https://doi.org/10.1021/ja00842a027research-articleACS PublicationsRequest reuse permissionsArticle Views179Altmetric-Citations49LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The Application of Genetic Algorithm to CSAMT Inversion for Minimum Structure (2008)

Abstract We apply genetic algorithm to invert CSAMT data. Here, we invert both apparent resistivity and phase data which contain the near‐field, transition zone field and the far‐field without any correction. The genetic algorithm is one kind of global optimization methods with less dependence on the initial model and better ability to find most available resolutions. But in the case of many unknowns the multi‐solution is still a problem. When we use a multi‐layer model in inversion, CSAMT does not yield a unique solution. In order to reduce the temptation to over interpret the data and to eliminate arbitrary discontinuities in simple layered models, we employ the minimum structure to constrain the invert result. We have defined minimum structure function for the CSAMT inversion, which is based on the genetic algorithm, and have found the optimal value of the Lagrange multiplier µ = 0.5. The designed models are H, A, K, Q and HKH, KHA. When the data have no noise or have 10% noise, the invert resistivity models fit the true models well. When the data contain 20% noise, the invert result is also good. The method has been used for field data processing, the result was good. Both synthetic and field data examples indicate that the method is effective.