gebhart/patrepeval huggingface dataset:
Abstract 16: Temporal Changes in Hemodynamics in Patients With Vertebrobasilar Disease: Results From the Prospective Multicenter VERiTAS Study (2016)

Introduction: The role of regional hypoperfusion as an important contributor to stroke risk in atherosclerotic vertebrobasilar (VB) disease has recently been confirmed by the observational Vertebrobasilar Flow Evaluation and Risk of Transient Ischemic Attack and Stroke (VERiTAS) Study. We examined the stability of hemodynamic status over time and relationship to stroke risk in patients followed in this prospective cohort. Methods: VERiTAS enrolled patients with recent VB TIA or stroke and ≥50% atherosclerotic stenosis or occlusion of vertebral and/or basilar arteries. Large vessel flow in the vertebrobasilar territory was assessed using quantitative MRA, and patients were designated as low flow or normal flow based on distal territory regional flow, incorporating collateral capacity. Patients underwent standard medical management and follow-up for primary outcome event of VB territory stroke. QMRA imaging was repeated at 6, 12 and 24 months. Flow status over time was examined relative to baseline, and relative to subsequent stroke risk using survival analysis. Results: Of 72 enrolled subjects, 50, 45 and 28 had follow-up QMRA at 6, 12 and 24 months respectively. 18 (25%) were characterized as low flow at baseline, 10% at 6 m, 20 % at 12m and 11% at 24m. Over 18±7months of follow-up, 7 of the 12 low flow patients (58%) with follow-up imaging had improved their flow status (low to normal) while only 3 of 44 normal flow patients (7%) had worsened. Baseline flow status has previously been demonstrated to be an independent stroke risk predictor; flow status at latest follow-up and prior to event remained a strong predictor of subsequent stroke (HR 4.9, CI 1.4 to16.9, p=0.01). Conclusions: There is potential both for improvement and worsening of hemodynamics in patients with atherosclerotic VB disease; improvement, likely attributable to development of collateral supply, was evident more frequently than worsening, presumably due to progression of disease. Flow status, both at baseline and over time, remains a robust risk factor for subsequent stroke, thus serving as an important prognostic marker.
Radiation dose in diagnostic radiology: Monte Carlo simulation studies (1984)

We applied Monte Carlo calculations to determine the radiation dose absorbed in water phantoms. Monoenergetic incident x-ray beams with energies from 15 to 100 keV and phantom thicknesses from 5 to 20 cm were considered in this study. We calculated the spatial distributions of energy absorption in the phantom, the rad/R conversion factors, the average rad/R conversion factors, and the scatter-to-primary ratios of absorbed dose. We also compared the relative absorbed doses under various imaging conditions when the transmitted radiation produced a given optical density on radiographic film. The information provided will be useful for the estimation of radiation doses in various radiographic procedures.
Imaging of α7 nicotinic acetylcholine receptors in brain and cerebral vasculature of juvenile pigs with [18F]NS14490 (2014)

[(18)F]NS14490 is not only comparable to other preclinically investigated PET radiotracers for imaging of α7 nAChR in brain but also could be a potential PET radiotracer for imaging of α7 nAChR in vulnerable plaques of diseased vessels.
SCAN — Automatizing libraries in African villages (2017)

Mobile devices have been helping to empower underserved communities around the world. From bringing information on health and farming to substituting expensive devices, cellular phones and apps have proved to be powerful tools in poverty alleviation and disaster relief. The Mobile Lab at Santa Clara University focuses on developing mobile solutions for social benefit and, in this paper, we describe the use of cellular phones and cloud services for automatizing libraries in African villages.
High power fiber-based chirped-pulse amplification system at 1550 nm with two amplifiers (2006)

We report on the experimental demonstration of a fiber-based chirped-pulse amplification system using a dispersion shifted fiber as stretcher, an electro-optic modulator for frequency division, two erbium-doped fiber amplifiers (a single mode and a large mode area) and a grating pair pulse compressor. We obtained 500-nJ pulses at a repetition rate of 1 MHz. Pulse duration was under 500 fs, which is in part due to the fine control of the beam polarization maintained throughout the system.
Nearly Optimal Semi-Supervised Learning on Subgraphs (2013)

The harmonic solution (HS) on a graph is one of the most popular approaches to semi-supervised learning. This is the first paper that studies how to identify highly confident HS predictions on a graph based on the HS on its subgraph. The premise of our method is that the subgraph is much smaller than the graph and therefore the most confident predictions can be identified much faster than computing the HS on the graph. We introduce a class of subgraphs that allow for good approximations, prove bounds on the difference in the HS on the graph and its subgraph, and propose an efficient approach to building the subgraphs. Our solution is evaluated in the domains of handwritten digit recognition, and topic discovery in restaurant and hotel reviews. In all cases, we show that only a small portion of the graph is sufficient to identify highly confident predictions.
Electrochemistry of organic conducting salt electrodes: a unified mechanistic description (1992)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemistry of organic conducting salt electrodes: a unified mechanistic descriptionShishan Zhao, Ulrich Korell, Louis Cuccia, and R. Bruce LennoxCite this: J. Phys. Chem. 1992, 96, 13, 5641–5652Publication Date (Print):June 1, 1992Publication History Published online1 May 2002Published inissue 1 June 1992https://pubs.acs.org/doi/10.1021/j100192a081https://doi.org/10.1021/j100192a081research-articleACS PublicationsRequest reuse permissionsArticle Views181Altmetric-Citations22LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Possible roles of LFA-1 and Fcγ receptors on the functional immaturities of cord blood polymorphonuclear leukocytes (1993)

The functional immaturity of PMNs is one of the major causes of overwhelming sepsis in newborns. In this study, we observed functions and surface markers of PMNs to investigate what causes the functional immaturity of PMNs in newborns. As results, the percentage of EA rosette forming PMNs (58.5 +/- 15.5%) and the chemotactic movement (0.14 +/- 0.09 mm) of cord blood PMNs were significantly lower than those of adult peripheral blood PMNs (70.8 +/- 9.9%, 0.60 +/- 0.34 mm). Cord blood PMNs showed decreased glass adherence and ADCC activity. The expression of Fc gamma RII or Fc gamma RIII was a little lower than those of adult peripheral blood PMNs, but the expression of Fc gamma RI (43.1 +/- 26.8%) was significantly higher than that of adult peripheral blood PMNs (3.2 +/- 1.8%). There was a significant difference in LFA-1 expression between EA rosette forming PMNs (92.9 +/- 9.1%) and EA rosette non-forming PMNs (25.6 +/- 22.6%). From these results, it is assumed that neonatal PMNs may consist of heterogeneous populations. And the relatively high percentage of EA rosette non-forming PMNs which express a low level of LFA-1 may be responsible for the functional immaturity of cord blood PMNs.
A knowledge and analytical-based intelligent system for customising logistics management (2007)

In recent years, logistics service companies have been seeking numerous technologies and logistics information systems to support daily logistics operations. However, the planning and decision making of logistics activities is still done manually, where subjective judgment is made by Logistics Service Providers (LSP) through analysing multiple knowledge/information sources and various quantitative and qualitative criteria. In this paper, the use of an intelligent Decision Support System (DSS), namely, Knowledge and Analytical-based Intelligent System (KAIS), to embed the information communication and decision support technology in aiding such decision-making process is explained. KAIS is developed by integrating Analytic Hierarchy Process (AHP), Case-Based Reasoning (CBR) and portal technologies seamlessly, which is suitable for application in various dynamic logistics operations environment. By using KAIS in Eastern Logistics Limited (ELL), the overall logistics service quality and customer satisfaction level is significantly enhanced through making accurate decision and systematic planning of logistics operations.
Racial and Ethnic Disparities in Pediatric Appendicitis Rupture Rate (2003)

The authors found evidence of significant racial/ethnic disparities in rate of appendiceal rupture, an important and preventable outcome, in two large but dissimilar states. Immigrant groups may be most at risk for delayed emergency care. Future research should focus on immigration and acculturation as risk factors for appendicitis rupture in children.
A Structure-Exploiting Algorithm for Nonlinear Minimax Problems (1992)

In this paper, some basic concepts are generalised which characterise the best linear Chebyshev approximation in one variable to general nonlinear minimax problems. A new method for solving a nonlinear minimax problem is presented, which exploits the structure and characterisation of the solution whenever possible. The algorithm is globally convergent with a superlinear convergence rate. Numerical results indicate the efficacy of the new method.
Build systems à la carte (2018)

Build systems are awesome, terrifying -- and unloved. They are used by every developer around the world, but are rarely the object of study. In this paper we offer a systematic, and executable, framework for developing and comparing build systems, viewing them as related points in landscape rather than as isolated phenomena. By teasing apart existing build systems, we can recombine their components, allowing us to prototype new build systems with desired properties.
Seedless, Surfactantless Room Temperature Synthesis of Single Crystalline Fluorescent Gold Nanoflowers with Pronounced SERS and Electrocatalytic Activity (2008)

A simple approach for the aqueous room temperature synthesis of marigold shape single crystalline fluorescent gold nanoflowers without using seeds or structure-regulating reagent and their SERS and electrocatalytic activity is described.
Postsilicon Voltage Guard-Band Reduction in a 22 nm Graphics Execution Core Using Adaptive Voltage Scaling and Dynamic Power Gating (2016)

In high volume manufacturing, conventional approach to deal with inverse-temperature dependence (ITD) and aging is to add a post silicon flat voltage guard band to all dies based on testing a small random sample of dies. Although this scheme guarantees error-free operation, it significantly degrades energy efficiency, as it penalize all dies for the maximum delay degradation due to ITD and aging as seen by the worst case die, while also assuming maximum aging condition. In this paper, a graphics execution core implemented in 22 nm trigate process uses per-die tunable replica circuit (TRC) to monitor delay degradation due to ITD and actual aging conditions. TRC triggers adaptive voltage scaling to dynamically adjust VCC as needed during run time to maintain correct operation at minimum additional voltage. Measured data show up to 33% (14%) energy savings at 0.4 V (0.8 V) compared with baseline scheme. The TRC is also utilized in a dynamic power gating (DPG) scheme to lower energy overhead due to fast droop guard band. DPG introduces a load line effect during normal operation, thus saving energy, while deactivating this load line upon droop detection by the TRC to maintain ISO performance as baseline. Silicon data show that DPG can improve energy efficiency by 14.5% (7%) at 0.8 V (0.6 V).
Neural Precursor Cells as Carriers for a Gene Therapeutical Approach in Tumor Therapy (2003)

Conventional therapeutical approaches such as surgery, radiotherapy, or chemotherapy have been shown to be rather unsuccessful in the treatment of infiltrative growing tumors such as the malignant glioblastoma multiforme. Thus, new therapeutical strategies have to be developed that are suitable for inducing cell death also in migrating tumor cells. These new therapeutical stategies include cell and/or gene therapeutical approaches. We demonstrate that glial-restricted progenitor cells as well as embryonic stem cell-derived neural stem cells belong to cell populations applicable to such therapeutical concepts. Both cell types can be efficiently transduced using a third-generation high-capacity "gutless" adenoviral vector, and show a tropism for the F98 glioma cells by migrating towards a spheroid of F98 glioma cells with a tendency to form a barrier around the tumor spheroid in an in vitro tumor confrontation model. Moreover, in a migration assay, secretion products of glial-restricted precursor cells have shown a potency to inhibit the migratory activity of glioma cells in vitro. In vivo, F98 glioma cell-derived tumor formation in the right striatum resulted in migration of glial as well as neural precursor cells towards the tumor area when cotransplanted in the corpus callosum of the contralateral hemisphere. After arrival, both cell types surround the tumor mass and even invade the experimentally induced tumor. These data indicate that glial-restricted as well as embryonic stem cell-derived neural precursor cells are good candidates as carriers for an ex vivo gene therapeutical approach in tumor therapy.
Integrating wireless sensor networks and cyber-physical systems: challenges and opportunities (2016)

The integration of wireless sensor networks (WSNs) with cyber-physical systems (CPSs) has led to the emergence of a new framework which aims to respond to the need for `smart everything&apos; and to bring important benefits for the nation and indeed for society as a whole. The starting point in achieving this goal is represented by the thorough analysis of the research challenges posed by CPSs, whose inputs are provided by large numbers of wireless sensors grouped in sensor networks. The deployment of CPSs spanning multiple WSNs generates tremendous opportunities that justify research in this domain. Following this approach, this chapter presents the main characteristics, application areas and design issues of WSNs, and the definitions, main characteristics, application domains and two types of architecture for CPSs. Scientific and technical barriers, and social and institutional problems are identified and enumerated. Further, the chapter gives an overview of the following research challenges posed by WSNs and CPSs and by their symbiosis: power consumption, communication, dependability, security, quality of services and Big Data analytics, among others. The chapter concludes with a discussion of the research, development, financial and market opportunities brought by the response to the synergy between these two domains.
Synthese von Bryophyten-Inhaltsstoffen 2. Synthesen von prenylierten Bibenzyl-Derivaten (1991)

Synthesis of Bryophyte Components 2. Syntheses of Prenylated Bibenzyl Derivatives Efficient and expeditious syntheses of the biologically active prenylated bibenzyl derivatives 1a-d are developed giving rise to their access on a preparative scale.
A novel protection scheme for DC electrical railway systems using high-frequency signal injection (2017)

A new protection scheme for DC electrical traction supply systems is introduced in this paper. The method is based on continuous measurement of the high-frequency impedance of the electric supply system. The high-frequency impedance of traction supplies is shown to be correlated to the physical integrity of the system. The measurement is synthesized by injecting the high frequency signal in the line and blocking the measurement signal from low-impedance paths, such as the train and substations. Using this injection and blocking technique, a new high-frequency system, which is sensitive to leakage currents, is created. The proposed method can be used for both protection and monitoring of the physical condition of the system. The method is non-intrusive, non-destructive, and can be used for both DC and AC systems without making major changes to the existing system, or incurring large costs. The proposed high-frequency based electrical railway monitoring system is analyzed, simulated, built, and experimentally verified.
Synthesis and analysis of novel polymers with potential for providing both high permselectivity and permeability in gas separation applications: Progress report, December 1987--December 1988. [Polycarbonates and polysulfones] (1988)

We have achieved the following significant objectives: obtained all of the polycarbonate and polysulfone materials proposed for our study except the hexafluorotetramethyl polysulfone material, and plans are in place to synthesize this material; completed permeation and sorption characterization with a spectrum of gases in most of the originally proposed polycarbonate and polysulfone materials. These data allow separating the structure-property effects of thermodynamic factors (sorption) from kinetic factors (diffusivity); completed high pressure mixed gas permeation studies with CO/sub 2/ and CH/sub 4/ to help define the conditions where plasticization-induced loss in permselectivity are expected to be significant; obtained and tested additional polymers in these two classes of materials to further test general rules that have evolved to guide material selection for high performance gas separation membranes. 3 figs., 3 tabs.
A highly efficient Li<sub>2</sub>O<sub>2</sub> oxidation system in Li–O<sub>2</sub> batteries (2016)

A novel indirect charging system that uses a redox mediator was demonstrated for Li-O<sub>2</sub> batteries. 4-Methoxy-2,2,6,6-tetramethylpiperidinyl-1-oxyl (MeO-TEMPO) was applied as a mediator to enable the oxidation of Li<sub>2</sub>O<sub>2</sub>, even though Li<sub>2</sub>O<sub>2</sub> is electrochemically isolated. This system promotes the oxidation of Li<sub>2</sub>O<sub>2</sub> without parasitic reactions attributed to electrochemical charging and reduces the charging time.
215.10: Tolerant Kidney Transplant Recipients Display a Unique CTLA-4 Dominant Urinary Cell mRNA Signature (2022)

Introduction: Urinary cell mRNA profiling provides an unparalleled window into the intra-graft events in kidney transplant recipients. Utilizing this powerful molecular tool, we aimed to characterize mRNA signatures associated with human kidney allograft tolerance induced with tolerogenic CD8+/TCR- facilitating cells (FCR001) and a nonmyeloablative conditioning regimen. Methods: We developed a custom panel of mRNAs encoding immunoregulatory proteins implicated in allograft tolerance and rejection and measured absolute levels of urinary cell mRNAs using preamplification enhanced real time quantitative PCR assays. We quantified urinary cell mRNA levels in 28 biopsy-matched urines from 14 FCR001-tolerant patients with durable chimerism and off immunosuppression (FCR Durable Cohort); 43 biopsy-matched urines from 34 kidney allograft recipients prospectively enrolled in the Clinical Trials in Organ Transplantation-04 (CTOT-04) and with biopsies with acute cellular rejection (TCMR Cohort); and 161 biopsy-matched urines from 124 kidney transplant recipients prospectively enrolled in CTOT-04 and with biopsies without rejection features (No Rejection Cohort). Results: Urinary cell mRNA profile of the FCR Durable Cohort was unique and discriminated the tolerant patients from the patients with TCMR biopsies and the patients with No Rejection biopsies. Absolute levels of urinary cell mRNAs, summarized in Table 1, show that the median level of CTLA-4 mRNA is significantly higher in the FCR Durable Cohort (median 439 copies per microgram of RNA) than in the TCMR cohort (135 copies) or the No Rejection Cohort (13 copies) (Kruskal Wallis [KW] P= 8x10-21). In contrast, urinary cell level of mRNA encoding cytotoxic attack molecule granzyme B was significantly lower in the FCR Durable Cohort (median 106 copies) than in the TCMR cohort (3304 copies) or the No Rejection Cohort (337 copies) (KW P= 1x10-11). The differential gene expression pattern resulted in the ratio of CTLA-4 mRNA to granzyme B mRNA to be significantly higher in the FCR Durable Cohort (5.62) than in the TCMR Cohort (0.03) or the No Rejection Cohort (0.04) (KW P= 1x10-14). Urinary cell levels of mRNA for CD3E, perforin, IP-10, FoxP3, and TGFB1 in the FCR Durable Cohort were significantly lower in the TCMR Cohort and mostly like the profile in the No Rejection Cohort. Comparison to an FCR Transient Cohort (11 biopsy-matched urines from 3 patients conditioned with the FCR001 regimen but with transient chimerism and on immunosuppression) revealed a higher ratio of CTLA-4 mRNA to granzyme B mRNA in the FCR Durable Cohort compared to the FCR Transient Cohort (5.62 vs. 1.99,P=0.21). Conclusion: Kidney allograft tolerance induced with CD8+/TCR- facilitating cells and a nonmyeloablative conditioning regimen is associated with a tolerogenic signature of enhanced expression of CTLA-4 mRNA and decreased expression of mRNA for granzyme B and perforin. The research was supported, in part, by NIH grants U01AI63589 and R37AI051652.
Effect of Fiber Reinforcement on the Hydraulic Conductivity Behavior of Lime-Treated Expansive Soil—Reliability-Based Optimization Perspective (2016)

Expansive soils which create heave and shrinkage related distresses are considered to be extremely problematic globally. When these soils are used alone or in conjunction with fiber-reinforcement as hydraulic barriers in waste containment systems, their prime purpose is to impede flow. Polypropylene fiber materials are durable and sustain improvement in soil properties in the long run. In order to have intact bonding between the randomly mixed fiber and clay, an additive in the form of lime is considered. In this study, the combined effect of lime and randomly oriented polypropylene fiber inclusion on the hydraulic conductivity behavior of an expansive soil is evaluated. The dosage of lime was fixed at 6% resorting to soil–pH response. The effect of fiber type (fibercast and fibermesh), fiber dosage (0.2, 0.4, and 0.6% by weight of soil) and fiber length (6 mm and 12 mm) on the hydraulic conductivity behavior was studied. Statistical analysis was performed to correlate the hydraulic conductivity of treated expansive soil with dosage and length of randomly oriented polypropylene fibers. Two exponential best fit equations are proposed for estimating the hydraulic conductivity of treated expansive soils in terms of dosage and length of two types of polypropylene fibers. Further, reliability analysis was performed to examine the suitability of treated expansive soils for waste containment in municipal solid waste (MSW) landfills.
Response to Drs Abrams and Kellner (2007)

Department of Psychiatry, College of Physicians Surgeons of Columbia University, New York, NY [email protected]