gebhart/patrepeval huggingface dataset:
Water-Soluble Adamantane-Terminated Dendrimers Possessing a Rhenium Core (2001)

A novel type of radiometal-containing dendrimer with potential radiotherapeutical applications is described. Different generations of this adamantane-terminated, Fréchet-type dendrimer (28, 29, 30), each consisting of two dendritic wedge ligands around a rhenium core, have been synthesized in organic solvent via reaction with ReO(PPh(3))(2)Cl(3). Through complexation of their adamantane groups by beta-cyclodextrins (beta-CDs), these dendrimers were made water soluble (9.6, 0.4, and 0.2 mM, respectively). beta-CD-induced solubilization of the wedges in water allowed the complexes to be made under aqueous conditions, via reaction with rhenium gluconate. Not only does this strategy enable the facile synthesis of the radioactive analogue, the yields for these complex-formation reactions in water also turned out to be far higher than those observed for the reactions in organic solvents.
Preparation and properties as positive electrodes of PANI–LiNi0.8Co0.2O2 nanocomposites (2008)

PANI–LiNi0.8Co0.2O2 nanocomposite material with improved properties as positive electrode was prepared by a new synthesis method. In a first step, LiNi0.8Co0.2O2 mixed oxide in the form of a fine powder was dispersed in aniline and this suspension was sprayed on the surface of an aqueous solution of HCl and ammonium peroxodisulfate. The resulting PANI–LiNi0.8Co0.2O2 nanocomposite is spontaneously formed by polymerization of the aniline molecules present in the drops together with small particles of the oxide. This method induces the formation of nanocomposites showing a better distribution of the oxide particles in the polymer matrix than that observed in related PANI–LiNi0.8Co0.2O2 microcomposites prepared under ultrasound irradiation to disperse the oxide particles during PANI polymerization. Measurements of electrical conductivity and zeta potential, as well as structural characterization of PANI–LiNi0.8Co0.2O2 nanocomposites, reveal the existence of relatively strong interactions between the conducting polymer and the oxide particles. This feature determines higher values of the electrical conductivity (0.5 S cm−1) and of the average operative voltage (3.6 V), as well as of other technological parameters of the nanocomposite when it is used as the positive electrode of rechargeable lithium batteries, in comparison to those of the related microcomposite materials already reported.
Measurement of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:mi>C</mml:mi><mml:mi>P</mml:mi></mml:math>Violation Parameters with a Dalitz Plot Analysis of<mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" display="inline"><mml:msup><mml:mi>B</mml:mi><mml:mo>±</mml:mo></mml:msup><mml:mo>→</mml:mo><mml:msub><mml:mi>D</mml:mi><mml:mrow><mml:msup><mml:mi>π</mml:mi><mml:mo>+</mml:mo></mml:msup><mml:msup><mml:mi>π</mml:mi><mml:mo>−</mml:mo></mml:msup><mml:msup><mml:mi>π</mml:mi><mml:mn>0</mml:mn></mml:msup></mml:mrow></mml:msub><mml:msup><mml:mi>K</mml:mi><mml:mo>±</mml:mo></mml:msup></mml:math> (2007)

We report the results of a CP violation analysis of the decay B{+/-}-->D{pi{+}pi{-}pi;{0}}K{+/-}, where D{pi{+}pi{-}pi{0}} indicates a neutral D meson detected in the final state pi{+}pi{-}pi{0}, excluding K{S}{0}pi{0}. The analysis makes use of 324 x 10{6}e{+}e{-}-->BB[over ] events recorded by the BABAR experiment at the PEP-II e;{+}e;{-} storage ring. Analyzing the pi;{+}pi;{-}pi;{0} Dalitz plot distribution and the B{+/-}-->D{pi{+}pi{-}pi{0}}K{+/-} branching fraction and decay rate asymmetry, we find the following one-standard-deviation constraints on the amplitude ratio and on the weak and strong phases: 0.06<r{B}<0.78, -30 degrees <gamma<76 degrees , -27 degrees <delta<78 degrees . We also measure the magnitudes and phases of the components of the D{0}-->pi{+}pi{-}pi{0} decay amplitude.
Atomic Force Microscopy of an Organic Monolayer (1988)

Atomic force microscope images of polymerized monolayers of n-(2-aminoethyl)-10,12-tricosadiynamide revealed parallel rows of molecules with a side-by-side spacing of approximately equal to 0.5 nanometer. Forces used for imaging (10(-8) newton) had no observable effect on the polymer strands. These results demonstrate that atomic force microscope images can be obtained for an organic system.
Dynamic Range of Analog Optical Links: Do Optical Amplifiers Help? (2005)

Applications of analog optical links include CATV distribution, phased array antennas, antenna remoting, and as backbone for wireless communication systems (see for example [1]).
Lightweight energy prediction framework for solar-powered wireless sensor networks (2012)

This research studies lightweight energy prediction filters for solar-powered wireless sensor networks. A generalized prediction filter is developed from the empirical analysis of several solar intensity datasets. The Array of Beta Coefficients (ABC) energy prediction filter is proposed. A comparison metric is also proposed to evaluate different filters based on their accuracy, storage requirements, and calculation complexity. Simulation results show that the ABC filter has up to 8-fold accuracy improvement over other published filters.
A Triple-Band GNSS Receiver for High Accuracy Automotive Applications (2022)

Among on-board sensors, the Global Navigation Satellite System (GNSS) receiver plays a key role because of its unique capability of absolute and precise localization. Autonomous vehicles guidance and assistance, resilient timing and an increased demand for higher safety levels are motivating a rapid evolution toward multi-band GNSS receivers in the automotive (and industrial) segments. Triple-band GNSS has gained interest in the past years and found application in professional receivers and reference stations, mostly because of faster carrier-phase ambiguity resolution, stronger integrity constraints over linear combinations and higher signal availability for Real-Time Kinematic (RTK) algorithms. The deployment of new services for high-accuracy positioning, like Galileo HAS, BeiDou PPP-B2b and Quasi Zenith Satellite System (QZSS) CLAS is also taking benefit from the availability of multiple bands. In this latest applicative scenario, the third frequency plays a different role, acting as an additional downstream channel for the GNSS correction data. Signal modernization is definitely another strong enabler for the adoption of triple-band. With specific reference to system design and signal processing aspects, this article discloses a new compact GNSS chipset for automotive, capable to generate coherent triple band observables and correction data streams, including a demodulator for QZSS Code Shift Keying (CSK). The frequency plans, the supported mix of legacy and modernized signals and relevant Key Performance Indicators (KPI) are discussed for selected configurations, typically encountered in automotive precise-positioning and timing.
Higher-Order Wavefront Aberrations in Retinitis Pigmentosa (2005)

Increased higher-order wavefront aberrations were present in patients with RP with and without clinically observable PSC cataracts. The measurement of wavefront aberrations in patients with RP provides an objective and quantitative method for detecting and monitoring disease-related changes in the optics of the eye.
Fluorescence-based, multiplex allele-specific PCR (MASPCR) detection of the ΔF508 deletion in the cystic fibrosis transmembrane conductance regulator (CFTR) gene (1992)

Cystic fibrosis (CF) is a common genetic disorder in Caucasians, and in some populations 70% of cases are associated with a 3 base pair (bp) deletion (delta F508) in the CFTR gene. We have implemented a fluorescence-based, multiplex allele-specific polymerase chain reaction (MASPCR) assay for deletion of the delta F508 mutation. Different allele-specific fluorescently-tagged primers are used in the PCR reaction to distinguish between normal and delta F508 alleles. Fluorescent PCR products are then visualized in a single lane on an agarose gel following electrophoresis combined with real-time multicolour fluorescence detection. The approach simplifies diagnosis of the most common mutation in the CFTR gene, and holds promise for a multiplex allele-specific, fluorescence-tagged gene amplification strategy for detection of additional CF mutations which may result in more cost-effective testing without increasing the risk of missed or erroneous diagnoses.
Pressure-induced phase separation for microstructural formation control in supercritical polymer solution: A promising solution enhancing mechanical properties of flash-spun filament (2022)

Abstract Flash-spun nonwoven (FS-NW) is gaining attention in the PPE field due to its excellent barrier and mechanical properties resulting from its non-uniform diameter distribution and unique filament morphology. The unique network structure of flash-spun filaments (FSF) comprising the FS-NW can be controlled by phase separation behavior in the supercritical fluid (SCF) process. This study proposes a simple method to control the microstructure of FSFs by controlling the pressure-induced phase separation (PIPS) process in polymer/SCF solution. This phase separation behavior of an HDPE/SCF solution was confirmed by using a high-pressure view cell. A multistage nozzle allowing for phase-separated pressure to form different phases was also designed. HDPE-FSFs were synthesized by flash-spinning, and their morphology, crystallinity, and mechanical properties were investigated. The results demonstrated that the filaments obtained by PSP control at 220°C and with an HDPE concentration of 8 wt% showed a network structure composed of strands, wherein the diameters ranged from 1.39 to 40.9 µm. Optimal FSF was obtained at 76 bar, with a crystallinity of 65.6% and a tenacity of 2.88 g/d. The PIPS method can thus effectively control the microstructure more feasibly than temperature- or solvent-induced techniques and can allow the effective synthesis of various products.
Spectral Analysis for DIAL and Lidar Detection of TATP (2008)

Abstract : The preliminary development and use of a tunable 10.6 micron C02 laser DIAL system for the remote sensing of TATP explosive gases was experimentally studied. TATP has a large vapor pressure with strong absorption features near 3.3 micron. 8.4 micron, and 10.6 micron. Toward this end, a tunable C02 DIAL system was constructed using a tunable l-W CW C02 laser, diagnostic spectrometers. 16 diameter telescope and cooled HqCdTe detectors. The backscatter lidar return from a remote retro-reflector target at a range of about 100m was used for the lidar/DIAL signal. The DIAL beam was also transmitted through a laboratory absorption cell containing an injected small sample of TATP. Detection and measurements of the TATP gas concentration in the cell were made at levels of 1 ng/micro liter. However, the concentration of TATP was found to be unstable over long periods of time due possibly to re-absorption and crystallization of the TATP vapors on the absorption cell windows. Our results also indicate that a more optimized pulsed C02 laser DIAL system could be used for greater detection ranges, and that pulsed DIAL systems near 3.3 micron and 8.4 micron could also be used for TATP detection.
Spectroscopic studies of the photochromic molecule N-(2-hydroxybenzylidene)aniline and its photoproduct (1990)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSpectroscopic studies of the photochromic molecule N-(2-hydroxybenzylidene)aniline and its photoproductWayne. Turbeville and Prabir K. DuttaCite this: J. Phys. Chem. 1990, 94, 10, 4060–4066Publication Date (Print):May 1, 1990Publication History Published online1 May 2002Published inissue 1 May 1990https://pubs.acs.org/doi/10.1021/j100373a033https://doi.org/10.1021/j100373a033research-articleACS PublicationsRequest reuse permissionsArticle Views251Altmetric-Citations95LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts
Stress resilience during the coronavirus pandemic (2020)

The epidemic of the 2019 novel coronavirus SARS-CoV-2, causing the coronavirus disease 2019 (COVID-19) is a global public health emergency with multifaceted severe consequences for people's lives and their mental health. In this article, as members of the European College of Neuropsychopharmacology (ECNP) Resilience, we will discuss the urgent need for a focus on resilience during the current coronavirus pandemic. Resilience is pivotal to cope with stress and vital to stay in balance. We will discuss the importance of resilience at the individual and societal level, but also the implication for patients with a psychiatric condition and health care workers. We not only advocate for an increased focus on mental health during the coronavirus pandemic but also highlight the urgent need of augmenting our focus on resilience and on strategies to enhance it.
A Myc-regulated transcriptional network controls B-cell fate in response to BCR triggering (2009)

Abstract Background The B cell antigen receptor (BCR) is a signaling complex that mediates the differentiation of stage-specific cell fate decisions in B lymphocytes. While several studies have shown differences in signal transduction components as being key to contrasting phenotypic outcomes, little is known about the differential BCR-triggered gene transcription downstream of the signaling cascades. Results Here we define the transcriptional changes that underlie BCR-induced apoptosis and proliferation of immature and mature B cells, respectively. Comparative genome-wide expression profiling identified 24 genes that discriminated between the early responses of the two cell types to BCR stimulation. Using mice with a conditional Myc -deletion, we validated the microarray data by demonstrating that Myc is critical to promoting BCR-triggered B-cell proliferation. We further investigated the Myc- dependent molecular mechanisms and found that Myc promotes a BCR-dependent clonal expansion of mature B cells by inducing proliferation and inhibiting differentiation. Conclusion This work provides the first comprehensive analysis of the early transcriptional events that lead to either deletion or clonal expansion of B cells upon antigen recognition, and demonstrates that Myc functions as the hub of a transcriptional network that control B-cell fate in the periphery.
ChemInform Abstract: SYNTHESIS AND BIOLOGICAL EVALUATION OF 10‐OXA‐11‐DEOXYPROSTAGLANDIN E1 AND 10‐NOR‐9,11‐SECOPROSTAGLANDIN F1 AND THEIR DERIVATIVES (1978)

Abstract Die Reduktion des Cyclooctenylmalonesters (Ia) liefert das Dio1(Ib), das nach Ozonolyse in das Lacton (IIa) übergeführt wird.
Self-Assembling Nanoparticles: A Unique Method for Downhole Sand Consolidation (2017)

Abstract When the formation is unconsolidated, sand particles can be produced into the wellbore. Such production of sand particles is undesirable as it lowers the permeability of the producing zone, erodes surface and downhole equipment. Costly intervention may be required to mitigate the damage to the well integrity and the reservoir deliverability. The most common methods of controlling this unwanted sand production involve: 1. Filter produced fluids through a gravel pack retained by a screen or 2. Use of consolidating fluids such as resin, a curing agent, along with other chemicals to create a conducive environment for the resin curing reaction to occur. The gravel packing completion requires special tools and equipment therefore higher cost. In the case of sand control by chemical consolidation, the resinous material tends to have relatively uncontrollable setting times, strength, placement, and regained permeability leading to unsuccessful treatment. With both cost and treatment effectiveness in mind, it is desirable to develop an improved material and method to mitigate sand production by consolidating the formation sand without impairing well productivity or injectivity. The present paper describes the development of a unique chemistry for sand control in unconsolidated formations. This chemistry involves using positive charge modified nanoparticles that can self-assemble over the unconsolidated formation sand particles to form a layer of consolidating material thus preventing any unwanted sand production. The new consolidation treatment material consists of colloidal nanoparticles modified using a cationic modifier and ionic strength modifier that can be placed downhole as a single pill. The pill has high affinity to the solid surface therefore less prone to build up in the pore space. Once cured at reservoir temperature it forms a thin layer of hard gel around the surface of the sand particles, thus cementing the sand grains together at the same time maintaining open porosity to ensure easy flow of produced hydrocarbons or injected water. The newly developed sand consolidation formulation was studied for their ability to consolidate loose sand and at the same time maintain good permeability. The effect of various ionic modifiers on consolidation properties was studied. The ability of the cationic modified nanoparticles to self-assemble around unconsolidated sand and eventually cure to form a consolidated sand pack was investigated. Regain permeability studies showed good regain permeability of the consolidated sand pack. Furthermore, this paper describes the concentration effect of the cationic modifier on the regain permeability. Finally, it shows that the new product provides a controllable curing time, thus avoiding any premature setting of the nanoparticles in the wellbore.
Network analysis reveals a major role for 14q32 cluster miRNAs in determining transcriptional differences between IGHV-mutated and unmutated CLL (2022)

Abstract Tumour cells from patients with chronic lymphocytic leukaemia (CLL) can express unmutated (U-CLL) or mutated (M-CLL) immunoglobulin heavy chain (IGHV) genes with differing clinical behaviours, variable B cell receptor (BCR) signalling capacity and distinct transcriptional profiles. As it remains unclear to what extent these differences reflect the tumour cells’ innate pre/post germinal centre origin or their BCR signalling competence, we applied RNA sequencing, small RNA sequencing and DNA methylation array analysis to 38 CLL cases categorised into three groups by IGHV mutational status and BCR signalling capacity. We identified 492 mRNAs and 38 miRNAs differentially expressed between U-CLL and M-CLL, but only 9 mRNAs and 0 miRNAs associated with BCR competence within M-CLL. A significant proportion of the IGHV-associated miRNAs derived from chr14q32 clusters (14/38 (37%)), where all miRNAs were co-expressed with the MEG3 lncRNA, as part of the DLK1-DIO3 genomic imprinted region, a locus of known importance in the pathogenesis of other human tumours. Integrative in silico analysis of miRNA/mRNA data revealed pronounced regulatory potential for the 14q32 miRNAs, potentially accounting for up to 25% of the IGHV-related transcriptome signature. GAB1, a positive regulator of BCR signalling, was predicted to be regulated by five 14q32 miRNAs and we confirmed that two of these (miR-409-3p and miR-411-3p) significantly repressed activity of the GAB1 3’UTR. Our analysis demonstrates a potential key role of the 14q32 miRNA locus in the regulation of CLL-related gene regulation.
Molecular distinctions between variant and classic hairy cell leukemia (2008)

18002 Background: 10–20% of patients with hairy cell leukemia (HCL) have a variant (HCLv) that presents with high tumor burden in spleen and peripheral blood, and is less responsive to purine analogs. HCLv cells lack CD25 and sometimes CD103. Differentiating HCLv from classic HCL (HCLc) is often difficult and it is unclear whether HCLv and HCLc are different disorders. Detailed molecular distinctions between HCLv and HCLc have not been reported. Methods: Patients with HCL were studied by flow cytometry and PCR to sequence the monoclonal immunoglobulin heavy chain rearrangements. Differences were analyzed by Fisher's exact and Wilcoxon non-parametric tests. Results: 50 and 21 VH-D-JH rearrangements were obtained from 49 HCLc and 19 HCLv patients, respectively. All rearrangements except 2 each for HCLc and HCLv were productive with no premature termination codons. The incidence of VH4 usage was higher in HCLv than in HCLc (57% vs 20%, p=0.0041). VH4–34 was the most common VH gene in HCLv and was more common in HCLv than in HCLc (33% vs 8%, p=0.012). The percentage of rearrangements which were unmutated (defined as < 2% somatic mutations) was higher in HCLv than in HCLc (43% vs 18%, p=0.038), but % homology was similar in both groups by rank order (median 94.9 vs 94.3% p=0.22). However, in comparing 11 VH4–34 with 60 other rearrangements, homology was higher with VH4–34 (median 99.2 vs 95.2%, p < 0.0001). In fact, the higher frequency of unmutated rearrangements in HCLv vs HCLc was due to VH4–34 cases alone, since the 7 HCLv VH4–34 rearrangements were all unmated and had higher homology than the other 14 HCLv rearrangements (median 99.6 vs 94.2%, p=0.006). Moreover, unmutated rearrangement incidence was similar between HCLv and HCLc for non-VH4–34 cases (14 vs 13%, p=1.0, median homology 94.2% vs 95.3%, p=0.5). Of the 4 VH4–34+ HCLc (CD25+) patients, 3 (75%) had unmutated rearrangements, and these 3 all had clinical features of HCLv, including presenting with lymphocytosis, large splenomegaly, absent cytopenias, and primary failure of purine analog treatment. Conclusions: No molecular distinctions between HCLv and HCLc were observed in VH4–34-negative patients. Our data suggest VH4–34-positive HCL is itself a variant of HCL affecting ∼15% of our patients. Such patients have features of HCLv, but their HCL cells can be CD25+. No significant financial relationships to disclose.
Optimal Placement of Unified Power Flow Controller by Dynamic Implementation of System-Variable-Based Voltage-Stability Indices to Enhance Voltage Stability (2015)

Abstract A new approach of unified power flow controller (UPFC) optimal placement in the power system network based on dynamic analysis of voltage stability is presented in this paper. Voltage stability indices (VSIs), called line stability index LQP, voltage collapse point indicators (VCPIs), and line stability factor Lmn have been employed to explore the most suitable location for UPFC. The locations of UPFC are identified by dynamically varying loads across all the PQ buses by different percentages to satisfy the real power system conditions. The simulations are conducted in a power system computer-aided design (PSCAD) environment where IEEE-39 bus system has been chosen as case study. The effectiveness of the proposed method has been ensured from the simulation results because UPFC's placement in the obtained locations resulted in an improved voltage stability condition. Furthermore, to verify the suitability of the explored locations, a comparative study has been conducted after placing UPFC in the present locations and other locations obtained using optimization techniques like particle swarm optimization (PSO), differential evolution (DE), genetic algorithm (GA), and bacteria foraging algorithm (BFA). In all the cases, UPFC's placement in the identified locations using the proposed approach has resulted in better voltage stability condition improvement compared to heuristics approaches.