gebhart/patrepeval huggingface dataset:
Übertragung und Gegenübertragung in der Behandlung von Dependenten Persönlichkeitsstörungen (2014)

Ein zentrales Merkmal aller Personlichkeitsstorungen sind Abweichungen von kulturellen Normen im interpersonalen Bereich. Die Dependente Personlichkeitsstorung wurde jedoch bisher kaum im Hinblick auf die Struktur und Qualitat enger Beziehungen untersucht. In dieser Arbeit wird die Entstehung dieser Storung auf der Grundlage des Modells Zyklisch-maladaptiver Muster (Cyclic Maladaptive Pattern, CMP) beschrieben. Die Folgen abhangigen Verhaltens fur zwischenmenschliche Beziehungen einschlieslich der therapeutischen Beziehung werden dargestellt. Die Ubertragung des Patienten ist meist durch einen starken Wunsch nach Fursorge und Unterstutzung durch den Therapeuten gekennzeichnet. Im Prozess der Gegenubertragung fuhlt sich der Therapeut durch die hohe Compliance des Patienten oft aufgewertet. Das CMP-Modell bietet eine Leitlinie zur Aufdeckung dieser Prozesse und zu ihrer Nutzung als therapeutische Strategien. Durch die schrittweise Reduktion der therapeutischen Hilfe wird der Patient darin unterstutzt, die abhangigen Muster in autonomeres Verhalten umzuwandeln. Zur Veranschaulichung der psychodynamischen Behandlung wird ein Fallbeispiel dargestellt.
Inhibition of Periodontitis Induction Using a Stimuli‐Responsive Hydrogel Carrying Naringin (2016)

Naringin-carrying CHC-β-GP-glycerol colloidal hydrogel can be used to inhibit induction of experimental periodontitis with favorable handling and inflammation-responsive characteristics.
Integration analysis of pSK41 in the chromosome of a methicillin-resistant Staphylococcus aureus K-1 (2002)

An integrate of pUB110 carrying aadD and blmS genes conferring resistance to 4'-OH containing aminoglycosides and bleomycin, respectively, is found in the Staphylococcal conjugative plasmid pSK41 and in the mec chromosomal region. In this study, we found an integrated copy of pSK41 in the chromosome of an arbekacin-resistant MRSA strain, K-1, clinically isolated in Japan. This is the first report of the chromosomal integration of this large plasmid in MRSA. Analysis of the nucleotide sequence and restriction map revealed a complete homology of the blmS-containing region of the integrate to wild type pSK41, except for the deletion of aadD and a part of the repU gene. In addition, we have discovered an insertion of IS1182 within the pSK41 integrate. Pulse-field gel electrophoresis-Southern analysis showed that the integration occurred outside the mec region. We also found that deletion of aadD resulted in an aberration of blmS transcription.
Reduced Serum Sphingolipids Constitute a Molecular Signature of Malnutrition in Hospitalized Patients With Decompensated Cirrhosis (2019)

Malnutrition in hospitalized cirrhotic patients is characterized by reductions in multiple sphingolipid species. Dysregulated sphingolipid metabolism may be involved in the pathophysiology of malnutrition in cirrhosis and potentially serve as a biomarker of nutritional status in this population.
Global Manhunt Pushes the Limits of Social Mobilization (2012)

Using social media and only the targets' mug shots, a team competing in the US State Department-sponsored Tag Challenge located three of five targeted people in five cities in the US and Europe in less than 12 hours.
Druggability (2016)

The evolution that has taken place in medicinal chemistry practice as a result of major advances in genomics and molecular biology arising from the Human Genome Project has carried with it an extensive additional working vocabulary that has become both integrated and essential terminology for the medicinal chemist. Some of this augmented terminology has been adopted from the many related and interlocked scientific disciplines with which the modern medicinal chemist must be conversant, but many other terms have been introduced to define new concepts and ideas as they have arisen. In this supplementary Glossary, we have attempted to collate and define many of the additional terms that are now considered to be essential components of the medicinal chemist’s expanded repertoire.
A COMPARTMENTAL MODEL OF URANIUM IN HUMAN HAIR FOR PROTRACTED INGESTION OF NATURAL URANIUM IN DRINKING WATER (2009)

To predict uranium in human hair due to chronic exposure through drinking water, a compartment representing human hair was added into the uranium biokinetic model developed by the International Commission on Radiological Protection (ICRP). The hair compartmental model was used to predict uranium excretion in human hair as a bioassay indicator due to elevated uranium intakes. Two excretion pathways, one starting from the compartment of plasma and the other from the compartment of intermediate turnover soft tissue, are assumed to transfer uranium to the compartment of hair. The transfer rate was determined from reported uranium contents in urine and in hair, taking into account the hair growth rate of 0.1 g d(-1). The fractional absorption in the gastrointestinal tract of 0.6% was found to fit best to describe the measured uranium levels among the users of drilled wells in Finland. The ingestion dose coefficient for (238)U, which includes its progeny of (234)Th, (234m)Pa, and (234)Pa, was calculated equal to 1.3 x 10(-8) Sv Bq(-1) according to the hair compartmental model. This estimate is smaller than the value of 4.5 x 10(-8) Sv Bq(-1) published by ICRP for the members of the public. In this new model, excretion of uranium through urine is better represented when excretion to the hair compartment is accounted for and hair analysis can provide a means for assessing the internal body burden of uranium. The model is applicable for chronic exposure as well as for an acute exposure incident. In the latter case, the hair sample can be collected and analyzed even several days after the incident, whereas urinalysis requires sample collection shortly after the exposure. The model developed in this study applies to ingestion intakes of uranium.
Real time monitoring of gases emitted from soils using a multi-turn time-of-flight mass spectrometer “MULTUM-S II” (2014)

Many miniaturized mass spectrometers used for on-site analysis have been designed and developed recently utilizing a broad range of analyzer platforms. These instruments are expected to have widespread applications covering many fields of interest. In our laboratory, a miniaturized multi-turn time-of-flight (TOF) mass spectrometer "MULTUM-S II" was designed and constructed. The size and weight of the developed "MULTUM-S II" are 45 cm × 23 cm × 64 cm and 36 kg. Irrespective of this small platform, it still boasts a high mass resolution capability of more than 30,000. In this study, we attempted to carry out real-time monitoring of gaseous compounds such as N2, O2, CO2, N2O and CH4. Using conventional miniaturized mass spectrometers, CO2 and N2O cannot be detected simultaneously due to the low mass resolution inherent to these established analyzer designs. Using a new method, "GC/high resolution mass spectrometry" described in this paper, real time monitoring of gases emitted from soils can be achieved. In a soil incubation experiment, CO2 and N2O started to increase just after water supplement and these gases varied similarly during the experiment, thus showing that this improved gas analyzing system could monitor the short time response of gaseous production in soil.
Abstract 258: Azilsartan Ameliorates Hypertension and Kidney Damage in Zucker Diabetic Fatty (ZDF) Rat (2013)

Azilsartan, an angiotensin II receptor blocker, demonstrated anti-hypertensive and organ protective effects in hypertension. We investigated if azilsartan can be utilized in ameliorating kidney damage associated with cardiometabolic syndrome using Zucker Diabetic Fatty (ZDF) rats. Two groups of 6-8 week-old male ZDF rats were treated with vehicle or azilsartan (10 mg/kg/d, p.o.) for 8 weeks. A set of male Zucker Diabetic Lean (ZDL) rats were used as the control group. At the end of the treatment period, urine and plasma samples were collected for biochemical analysis while kidney tissues were collected for histopathological examination (n=6/group). ZDF rats were diabetic with fasting blood glucose levels averaging 287±45 mg/dL compared to 107±6 mg/dL in ZDL rats. Azilsartan treatment ameliorated hyperglycemia in ZDF rats (167±46 mg/dL). ZDF rats were also hypertensive compared to ZDL rats (181±4 vs 126±4 mmHg), and azilsartan treatment attenuated blood pressure in ZDF rats (109±4 mmHg). ZDF rats demonstrated marked renal damage compared to ZDL with elevated urinary excretion of albumin (ZDF vs ZDL, 92±47 vs 4±2 mg/d) and nephrin (842±364 vs 16±4 μg/d). ZDF rats also had 2-4-fold higher tubular cast formation and glomerular injury compared to ZDL rats. In ZDF rats, azilsartan treatment markedly reduced renal injury by attenuating elevated urinary albumin (7±2 mg/d) and nephrin (73±28 ug/d) along with a reduction in renal tubular cast formation and glomerular injury index. ZDF rats demonstrated increased inflammation and oxidative stress with elevated urinary monocyte chemoattaractant protein-1 (MCP-1) excretion (ZDF vs ZDL, 645±373 vs 319±76 ng/d) and kidney malondialdehyde (MDA) content (5±1 vs 10±1 μmol/mg). Azilsartan treatment reduced inflammation and oxidative stress in ZDF rats by reducing MCP-1 (335±80 ng/d) and kidney MDA content (6±1 ug/d). In summary, we demonstrate marked kidney protective, anti-inflammatory, and anti-oxidative effects of azilsartan in cardiometabolic syndrome ZDF rats. Support provided by Takeda Pharmaceuticals Inc., USA
Subtelomeric 6p deletion: Clinical and array‐CGH characterization in two patients (2008)

We report on two patients with de novo subtelomeric terminal deletion of chromosome 6p. Patient 1 is an 8-month-old female born with normal growth parameters, typical facial features of 6pter deletion, bilateral corectopia, and protruding tongue. She has severe developmental delay, profound bilateral neurosensory deafness, poor visual contact, and hypsarrhythmia since the age of 6 months. Patient 2 is a 5-year-old male born with normal growth parameters and unilateral hip dysplasia; he has a characteristic facial phenotype, bilateral embryotoxon, and moderate mental retardation. Further characterization of the deletion, using high-resolution array comparative genomic hybridization (array-CGH; Agilent Human Genome kit 244 K), revealed that Patient 1 has a 8.1 Mb 6pter-6p24.3 deletion associated with a contiguous 5.8 Mb 6p24.3-6p24.1 duplication and Patient 2 a 5.7 Mb 6pter-6p25.1 deletion partially overlapping with that of Patient 1. Complementary FISH and array analysis showed that the inv del dup(6) in Patient 1 originated de novo. Our results demonstrate that simple rearrangements are often more complex than defined by standard techniques. We also discuss genotype-phenotype correlations including previously reported cases of deletion 6p.
Role of cytokines in termination of the B cell lymphoma dormant state in AKR mice. (1995)

The high incidence of spontaneous T cell lymphomas in AKR mice (affected by sustained viremia) can be greatly reduced by experimental manipulations including thymus removal at young age or by genetic manipulation changing the Fv-1 allele that controls replication and spread of viruses (establishing the congenic AKR.Fv-1b mice). Although T cell lymphomagenesis is prevented, all these mice were shown to carry endogenous ecotropic provirus-induced potential lymphoma cells (PLCs) in a dormant state. The termination of the dormant state, leading to a high incidence of CD5+ IgM+ B cell lymphomas, was triggered by interference with T cell functions (optimal effect observed following in vivo administration of anti-CD8 moAb), administration of T cell growth factors or by injecting the MCF-247 recombinant virus isolate (from AKR origin) that affects T cell functions. The assumption that the PLC dormant state is maintained through specific immunological mechanisms (involving T cells or antibodies recognizing PLCs) could not be substantiated experimentally. The results of the present studies suggest that T cells provide immunoregulatory signals or factors that contribute to the maintenance of the B cell lymphoma arrest and/or proliferation. Analysis of cytokine levels produced by splenocytes taken from mice during PLC dormancy or its breakdown indicated reduced levels of IL-2 and IL-4 and marked elevation of IL-1 and IL-6 associated with the termination of the dormant state. The effect of IL-1 and IL-6 on terminating the dormant state was demonstrated by injecting these cytokines into PLC carriers, thymectomized 12-month-old AKR mice, yielding 80-85% CD5+ IgM+ B cell lymphomas. The role of IL-6 on B cell lymphoma proliferation was also indicated in MCF-247 mediated termination of dormancy, by inhibiting significantly its effect via in vivo administration of anti IL-6 moAbs.
Pathways of Infusate Loss during Convection-Enhanced Delivery into the Putamen Nucleus (2013)

Our analysis demonstrates that after controlling for targeting, catheter type, infusion rate and infusate, the main issues during surgical planning are the identification of appropriate infusate volume that matches the target area, as well as mapping the regional vasculature as it may become a pathway for infusate loss. Most importantly, these results underscore the significance of presurgical planning for catheter placement and infusion, and the value of imaging guidance to ensure targeting accuracy.
Stochastic resonance can induce oscillation in a recurrent Hodgkin-Huxley neuron model with added Gaussian noise (2008)

Stochastic resonance (SR) has been shown to enhance the signal to noise ratio or detection of signals in neurons. It has not been clear yet if SR can play an important role in information processing in neural networks. In this paper, we test the hypothesis through computer simulations that SR can induce an oscillation phenomenon in a recurrent neural network with added Gaussian noise in which the recurrent model is constructed by four Hodgkin-Huxley (HH) neuron models. Each HH neuron model is driven by Gaussian noise and sub-threshold excitatory synaptic currents with an alpha function from another HH neuron model, and the action potentials (spike firings) of each HH neuron model are transferred to the other HH neuron model via sub-threshold synaptic currents. From spike firing times recorded, the inter spike interval (ISI) histogram was generated, and the periodicity of spike firings was detected from the ISI histogram at each HH neuron model. The results show that the probability of spike firings in the oscillation period (about 50 ms or 20 Hz) increases as the standard deviation (S.D.) of the Gaussian white noise increases, and reach a maximum value at a specific S.D. of the Gaussian white noise, implying that SR can improve sub-threshold synaptic transmission in the recurrent HH neuron model. It is concluded that an oscillation (20 Hz) can be induced by adding Gaussian white noise at lower amplitudes with intrinsic characteristics in the recurrent HH neuron model, while another oscillation (100 Hz) can be generated by the noise at greater amplitudes with extrinsic characteristics.
Estimation of Regionally Specific Z-R Relationships for Radar-Based Hydrologic Prediction (2010)

Radar-based hydrologic prediction relies on available rain gauges to correct for bias in rainfall estimates. Standard Z-R relationships have been developed, which are characteristic of storm types, e.g. convective or tropical storms. However, the evolution of storm drop size distribution and radar-specific factors can affect the accuracy of these standard relationships. Deriving Z-R relationships from rain gauge observations for specific radars offers the potential for improved rainfall estimation. The derived Z-R relationship would be more representative of local climatology and radar characteristics, and can be used when rain gauges are not available in real-time for bias correction. The purpose of this study is to derive and evaluate regionally and seasonally specific Z-R relationships for use in rainfall estimation for the South Florida Water Management District (SFWMD). These regionally specific relationships are expected to reduce bias in rainfall estimates found when using standard Z-R relationships, and lead to improved rainfall estimation for operational decisions.
Surface chemistry of hydroxyapatite (2020)

Hydroxyapatite (HA) or Ca<sub>10</sub>(PO)<sub>6</sub>(OH)<sub>2 </sub> is one of several phosphate minerals present on the surface of the early Earth during the Hadean and Archean eons. Phosphorus is one of six essential elements for life, with minerals as a primary source for this element because it does not have a stable volatile phase. Despite the low solubility and
Aveiro Joint Exercise Dataset (2019)

The current datasets comprise of air quality data collected during an AQ monitoring campaign in Aveiro, Portugal, for two weeks in October 2014 (from October 13 until October 27) in order to present the results of an intercomparison of AQ microsensors with reference methods. The two-week experimental campaign was conducted in an urban traffic location in Aveiro city centre. A total of 15 teams originating from various research centres, universities and companies from 12 different countries participated in the campaign. During the intercomparison campaign, the IDAD mobile laboratory was equipped with standard and reference analysers for continuous measurement of atmospheric pollutant concentrations and specific sensors for the measurement of meteorological parameters. Participating teams installed microsensors boxes on it for a co-location deployment experiment using different measuring principles. The dataset is composed by: Reference data (ground truth) - IDAD reference data (@1min rate) including CO, NO, NO2, NOx, O3, SO2, H2S concentrations (21183 data samples); - IDAD reference data (@15min rate) including NO, NO2, NOx, O3 concentrations (15 min averaged data) + CO2, Benzene, Toluene, Ethylbenzene, M&amp;P-Xylene, o-Xylene concentrations (1412 data samples); - IDAD reference data (@1h rate) including all the above mentioned pollutants concentrations plus PM2.5, PM10 concentrations and T, RH, Prec., WV, WD, Press., Rad. data (353 data samples); Microsensors data - 1minute sampled concentrations data provided by University of Cambridge "CAM10" and "CAM11" boxes, ECN "ECN10" and "ECN38" boxes, UCL/CCMOSS, VITO/EveryAware SB boxes; - 1 minute sampled raw uncalibrated data from Siemens microsensor box. - 5 minute sampled concentrations data provided by AUTh-ISAG, NanoEnvi box; - 15 minute sampled data provided by ENEA, AQMesh, VITO/EveryAware SB boxes; - 1 hour data provided by ENEA, NanoEnvi, VITO/EveryAware SB boxes.
Implementation issues for fast initial position and magnet polarity identification of PM synchronous machines with near zero saliency (2005)

This paper presents a significant discussion of implementation details of an enhanced fast initial position and magnet polarity estimation method for low saliency PM synchronous machines. The carrier frequency operating-point model of the machine has been extended to include the effect of cross-saturation as part of the non-linear interactions of the machine inductance to an applied rotating voltage vector. The resulting carrier signal current components are isolated using synchronous reference frame filtering and the initial position and magnet polarity is estimated using a dual-vector tracking state filter. The paper also provides an extended discussion of design tradeoffs in tuning of the synchronous reference frame filters in conjunction with the dual-vector tracking state filter bandwidth. Experimental results demonstrate fast, reliable initial position and magnet polarity estimation with improved accuracy and speed of convergence
Quantification of Volume Fraction of Precipitates in an Aged Al-1.0 mass%Mg&lt;SUB&gt;2&lt;/SUB&gt;Si Alloy (2000)

An Al-1.0 mass%Mg2Si alloy was aged at 473 K for 36 ks. Using the same sample, resistivity (ρ) measurements, tensile tests and TEM observations were carried out. The volume fraction (Vfρ) of precipitates was estimated from the decrement in resistivity due to aging. Length (λ), diameter (d) and number density (NP) per unit volume of the needle-shaped precipitates were measured on TEM micrographs. Perhaps because of initiation of overaging in the present aging condition, λ and NP showed a wide scatter and differed significantly in two equivalent samples, independently heat treated and tested. However, proof stress and Vfρ in the two runs well coincided with each other and the volume fraction estimated from TEM micrographs (Vf TEM) matched within a factor of 2 for the two runs.
CpG‐containing immunostimulatory sequences (ISS) exhibit potent inhibition of HCV replication in HCV replicon line (2008)

Only 50% of HCV‐infected patients respond to current treatment and many subjects experience adverse effects stemming from systemic IFN‐a administration, underlining the need for safer and more efficacious therapies. Exposure of Huh‐7 replicon cells, an in vitro HCV replication system, to supernatants from human PDCs stimulated with IFN‐a‐inducing CpG‐C ISS also displayed a potent ability to inhibit HCV replication that correlated with the quantity of IFN‐a present in the supernatants. To more closely mimic the in vivo situation, co‐cultures of replicon cells and human PDCs were established. In this case, HCV replication was also inhibited by direct ISS treatment, and optimal inhibition was achieved using lower doses of ISS than were necessary via PDC‐supernatant transfer. Type I IFN blockade during the co‐culture was insufficient to completely inhibit HCV replication, suggesting that other ISS‐induced factors contribute to controlling HCV replication. Furthermore, the dose of efficacious ISS could be further reduced when administered together with the antiviral drug ribavirin, suggesting that effective combination therapy might be achieved with low doses of ISS. These results suggest that a novel combination therapy of ISS and ribavirin could exhibit potent HCV suppressive activity while avoiding adverse events associated with high levels of systemic IFN‐a.
Multimodal Clustering with Role Induced Constraints for Speaker Diarization (2022)

Speaker clustering is an essential step in conventional speaker diarization systems and is typically addressed as an audio-only speech processing task.The language used by the participants in a conversation, however, carries additional information that can help improve the clustering performance.This is especially true in conversational interactions, such as business meetings, interviews, and lectures, where specific roles assumed by interlocutors (manager, client, teacher, etc.) are often associated with distinguishable linguistic patterns.In this paper we propose to employ a supervised text-based model to extract speaker roles and then use this information to guide an audio-based spectral clustering step by imposing must-link and cannot-link constraints between segments.The proposed method is applied on two different domains, namely on medical interactions and on podcast episodes, and is shown to yield improved results when compared to the audio-only approach.
Enhanced Near-Field Force Probing for In Vitro Biomechanical Characterization (2006)

This paper presents a fully automated micro-robotic system based on force/vision referenced control designed for mechanical cell characterization. The design of the prototype combines scanning probe microscopy (SPM) techniques with advanced robotics approaches. As a result, accurate and non-destructive mechanical characterization based on soft contact mechanisms are achieved. The in vitro working conditions are supported by the experimental setup so that mechanical characterization can be performed in biological environmental requirements as well as in cyclical operating mode during several hours. The design of the different modules which compose the experimental setup is detailed. Mechanical cell characterization experiments under in vitro conditions on human cervix epithelial Hela adherent cells are presented to demonstrate the viability and effectiveness of the proposed setup