gebhart/patrepeval huggingface dataset:
Near-Infrared Absorption Features of Triplet-Pair States Assigned by Photoinduced-Absorption-Detected Magnetic Resonance (2023)

Singlet fission proceeds through a manifold of triplet-pair states that are exceedingly difficult to distinguish spectroscopically. Here, we introduce a new implementation of photoinduced-absorption-detected magnetic resonance (PADMR) and use it to understand the excited-state absorption spectrum of a tri-2-pentylsilylethynyl pentadithiophene (TSPS-PDT) film. These experiments allow us to directly correlate magnetic transitions driven by RF with electronic transitions in the visible and near-infrared spectrum with high sensitivity. We find that the new near-infrared excited-state transitions that arise in thin films of TSPS-PDT are correlated with the magnetic transitions of T<sub>1</sub>, not <sup>5</sup>TT. Thus, we assign these features to the excited-state absorption of <sup>1</sup>TT, which is depleted when T<sub>1</sub> states are driven to a spin configuration that forbids subsequent fusion. These results clarify the disputed origin of triplet-associated near-infrared absorption features in singlet-fission materials and demonstrate an incisive general purpose tool for studying the evolution of high-spin excited states.
Robotic Adversarial Coverage (ICAPS-15 Doctoral Consortium) (2015)

Coverage is a fundamental problem in robotics, where one or more robots are required to visit each point in a target area at least once. While all previous work concentrated on finding a solution that completes the coverage as quickly as possible, in this thesis I consider a new and more general version of the problem: adversarial coverage. Here, the robot operates in an environment that contains threats that might stop the robot. The objective is to cover the target area as quickly as possible, while minimizing the probability that the robot will be stopped before completing the coverage. The adversarial coverage problem has many real-world applications, from performing coverage missions in hazardous environments such as nuclear power plants or the surface of Mars, to surveillance of enemy forces in the battle field and field demining. In my thesis I intend to formally define the adversarial coverage problem, analyze its complexity, suggest different algorithms for solving it and evaluate their effectiveness both in simulation and on real robots.
Shock/Boundary-Layer Interaction Effects on Transverse Jets in Crossflow over a Flat Plate (2009)

Covers advancements in spacecraft and tactical and strategic missile systems, including subsystem design and application, mission design and analysis, materials and structures, developments in space sciences, space processing and manufacturing, space operations, and applications of space technologies to other fields.
How Patients Dispose of Unused Prescription Opioids: A Survey of over 300 Postoperative Patients (2022)

Introduction Diversion of unused prescription opioids is a common source of opioid sensitization in the community. Educating patients about safe opioid use has been shown to be effective in decreasing opioid use. However, decreasing diversion will also require educating patients on proper opioid disposal. A survey was administered to better understand patients' habits with opioid disposal for opioids prescribed after orthopedic surgery. Methods A cross-sectional survey study of 469 patients who had undergone orthopedic surgery was conducted to learn their preferences and habits regarding the disposal of unused prescription opioids received after orthopedic surgery. Results The survey respondents consisted of 48.8% female and 51.2% male patients. Ninety-four point two percent (94.2%) of those receiving opioid prescriptions reported having leftover unused opioids. In terms of voluntary disposal, 68.8% claimed to dispose of their prescription opioids while 31.2% did not. Gender, but not age, had a significant effect on plans for opioid disposal and how seriously respondents viewed issues of opioid misuse. When asked their preferred location for prescription opioid disposal, the most common preference was a local pharmacy. Discussion This survey identified that most patients do not store their prescription opioids in a locked location, claim to dispose of their unused prescription opioids, and would prefer to dispose of them at a pharmacy if possible. This information points to the need for close prescriber-to-pharmacy collaboration to promote the safe disposal of prescription opioids and mitigate drug diversion.
Bragg Gratings in Index-guiding Photonic Crystal Fibres (2002)

A numerical investigation of coupling coefficients of Bragg-gratings in index-guiding photonic crystal fibres is presented. It is shown that index-guiding photonic crystal fibres have larger coupling coefficients for fibres with small core areas than step-index fibres
Comparing contemporary revision burden among hip and knee joint replacement registries (2016)

Revision burden has gradually decreased for hip replacements and has remained relatively constant for knee replacements both for the last 4 years and compared to historic controls. Knee revision burden was lower than hip revision burden for each period examined. Revision burden is one measure that may be helpful in following the effect of changes in surgical technique and implant design over time in registry populations and may be a helpful way to compare overall results between registries.
Adalimumab sustains steroid‐free remission after 3 years of therapy for Crohn’s disease (2011)

Adalimumab therapy resulted in modest but clinically meaningful rates of steroid-free remission, sustained over 3 years of treatment, in a heavily pretreated population of patients with Crohn's disease receiving steroids at the start of therapy (http://www.clinicaltrials.gov number: NCT00077779).
Pediatric Retina Current Thinking (2006)

Associated Retinal Consultants, Royal Oak, Grand Rapids, Traverse City, MI Reprint requests: Michael T. Trese, MD, 3535 W13 Mile Rd, Suite 632, Royal Oak, MI 48072.
Development of new non-oxide inorganic membranes for high temperature hydrogen separation (2012)

International audience
Aerobic Oxidations and Related Reactions Catalyzed by <i>N</i> ‐Hydroxyphthalimide (2004)

This chapter contains sections titled: Introduction NHPI-catalyzed Aerobic Oxidation Alkane Oxidations with Dioxygen Oxidation of Alkylarenes Oxidation of Alkylbenzenes Synthesis of Terephthalic Acid Oxidation of Methylpyridines and Methylquinolines Oxidation of Hydroaromatic and Benzylic Compounds Preparation of Acetylenic Ketones by Direct Oxidation of Alkynes Oxidation of Alcohols Epoxidation of Alkenes Using Dioxygen as Terminal Oxidant Baeyer-Villiger Oxidation of KA-Oil Preparation of ε-Caprolactam Precoursor from KA-Oil Functionalization of Alkanes Catalyzed by NHPI Carboxylation of Alkanes with CO and O2 First Catalytic Nitration of Alkanes Using NO2 Sulfoxidation of Alkanes Catalyzed by Vanadium Reaction of NO with Organic Compounds Ritter-type Reaction with Cerium Ammonium Nitrate (CAN) Carbon–Carbon Bond Forming Reaction via Generation of Carbon Radicals Assisted by NHPI Oxyalkylation of Alkenes with Alkanes and Dioxygen Synthesis of α-Hydroxy-γ-lactones by Addition of α-Hydroxy Carbon Radicals to Unsaturated Esters Hydroxyacylation of Alkenes Using 1,3-Dioxolanes and Dioxygen Hydroacylation of Alkenes Using NHPI as a Polarity-reversal Catalyst Conclusions References
Constitutive transgenic α-Klotho overexpression enhances resilience to and recovery from murine acute lung injury (2021)

Normal lungs do not express α-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related effects of modest Klotho overexpression on acute lung injury (ALI) and recovery. Transgenic Klotho-overexpressing (<i>Tg-Kl</i>) and wild-type (<i>WT</i>) mice (2 and 6 mo old) were exposed to hyperoxia (95% O<sub>2</sub>; 72 h; injury; Hx) then returned to normoxia (21% O<sub>2</sub>; 24 h; recovery; Hx-R). Control mice were kept in normoxia. Renal and serum Klotho, lung histology, and bronchoalveolar lavage fluid oxidative damage markers were assessed. Effects of hyperoxia on Klotho release were tested in human embryonic kidney cells stably expressing Klotho. A549 lung epithelial cells transfected with <i>Klotho</i> cDNA or vector were exposed to cigarette smoke; lactate dehydrogenase and double-strand DNA breaks were measured. Serum Klotho decreased with age. Hyperoxia suppressed renal Klotho at both ages and serum Klotho at 2 mo of age. <i>Tg-Kl</i> mice at both ages and 2-mo-old <i>WT</i> mice survived Hx-R; 6-mo-old <i>Tg-Kl</i> mice showed lower lung damage than age-matched <i>WT</i> mice. Hyperoxia directly inhibited Klotho expression and release in vitro; <i>Klotho</i> transfection attenuated cigarette smoke-induced cytotoxicity and DNA double-strand breaks in lung epithelial cells. Young animals with chronic high baseline Klotho expression were more resistant to ALI. Chronic constitutive Klotho overexpression in older <i>Tg-Kl</i> animals attenuated hyperoxia-induced lung damage and improves survival and short-term recovery despite an acute reduction in serum Klotho during injury. We conclude that chronic enhancement of Klotho expression increases resilience to ALI.
Treating ICB-resistant glioma with anti-CD40 and mitotic spindle checkpoint controller BAL101553 (lisavanbulin) (2021)

Glioblastoma is a highly malignant brain tumor with no curative treatment options, and immune checkpoint blockade has not yet shown major impact. We hypothesized that drugs targeting mitosis might affect the tumor microenvironment and sensitize cancer cells to immunotherapy. We used 2 glioblastoma mouse models with different immunogenicity profiles, GL261 and SB28, to test the efficacy of antineoplastic and immunotherapy combinations. The spindle assembly checkpoint activator BAL101553 (lisavanbulin), agonistic anti-CD40 antibody, and double immune checkpoint blockade (anti-programmed cell death 1 and anti-cytotoxic T lymphocyte-associated protein 4; anti-PD-1 and anti-CTLA-4) were evaluated individually or in combination for treating orthotopic GL261 and SB28 tumors. Genomic and immunological analyses were used to predict and interpret therapy responsiveness. BAL101553 monotherapy increased survival in immune checkpoint blockade-resistant SB28 glioblastoma tumors and synergized with anti-CD40 antibody, in a T cell-independent manner. In contrast, the more immunogenic and highly mutated GL261 model responded best to anti-PD-1 and anti-CTLA-4 therapy and more modestly to BAL101553 and anti-CD40 combination. Our results show that BAL101553 is a promising therapeutic agent for glioblastoma and could synergize with innate immune stimulation. Overall, these data strongly support immune profiling of glioblastoma patients and preclinical testing of combination therapies with appropriate models for particular patient groups.
Silver(I) Heptafluorobutanoate (2001)

[3794-64-7] C4AgF7O2 (MW 320.91) InChI = 1S/C4HF7O2.Ag/c5-2(6,1(12)13)3(7,8)4(9,10)11;/h(H,12,13);/q;+1/p-1 InChIKey = GPNIJXACCBKBEP-UHFFFAOYSA-M (decomposition of 3-diazocamphor;2 NMR shift reagent) Physical Data: mp 292–294 °C. Solubility: no readily available data, but probably soluble in a range of solvents, e.g. CHCl3, CH2Cl2, MeCN, alcohol, THF. Form Supplied in: white powder; widely available. Handling, Storage, and Precautions: handle in a fume hood with rubber gloves and safety glasses; avoid skin contact and inhalation. Store in a tight container in a cool place. Light sensitive. Severe eye irritant with an obnoxious smell. The toxicology of this compound has not been fully evaluated.
Removing direct photocurrent artifacts in optogenetic connectivity mapping data via constrained matrix factorization (2023)

Abstract Monosynaptic connectivity mapping is crucial for building circuit-level models of neural computation. Two-photon optogenetic stimulation, when combined with whole-cell recordings, has the potential to map monosynaptic connectivity at an unprecedented scale. However, optogenetic mapping of nearby connections poses a challenge, due to stimulation artifacts. When the postsynaptic cell expresses opsin, optical excitation can directly induce current in the patched cell, confounding connectivity measurements. This problem is most severe in nearby cell pairs, where synaptic connectivity is often strongest. To overcome this problem, we developed a computational tool, Photocurrent Removal with Constraints (PhoRC). Our method is based on a constrained matrix factorization model which leverages the fact that photocurrent kinetics are consistent across repeated stimulations at similar laser power. We demonstrate on real and simulated data that PhoRC consistently removes photocurrents while preserving synaptic currents, despite variations in photocurrent kinetics across datasets. Our method allows the discovery of synaptic connections which would have been otherwise obscured by photocurrent artifacts, and may thus reveal a more complete picture of synaptic connectivity. PhoRC runs faster than real time and is available at https://github.com/bantin/PhoRC .
Palladium Catalyzed [2 + 2 + 1] Intramolecular Cycloaddition for the Preparation of Bicyclo[3.3.0]octa‐1.5‐dien‐3‐ones from 1,6‐Diynes. (2003)

Abstract For Abstract see ChemInform Abstract in Full Text.
Hydrogen in soils and dust as observed in ChemCam spectra at Gale Crater, Mars. (2013)

Upprättat; 2013; 20150702 (ninhul)
A Self-Survivable WDM-PON Architecture with Centralized Wavelength Monitoring, Protection and Restoration for both Upstream and Downstream Links (2008)

A centrally-controlled, bi-directional WDM-PON architecture has been demonstrated. The self- survivable scheme can protect all types of failures in distribution and feeder fibers, remote nodes, and transmitters in CO and ONUs.
Forecasting Framework for Mobile Networks Based on Automatic Feature Selection (2023)

Traditionally, mobile network management has been based on reactive systems, where corrective actions are taken when a failure or a suboptimal network performance is detected. However, the requirements of low latency and high throughput associated with 5G new services, make these reactive systems insufficient to manage the new needs of users. Thus, the focus of mobile network management has changed to a proactive approach, where preventive actions are taken to avoid failures and suboptimal network performance. Moreover, in 5G, management algorithms are expected to make use of large amounts of information sources. The use of this large amount of information and the need to use historical data to generate forecasting models, may cause a loss of accuracy. To address these challenges, a forecasting framework is proposed in this work. The framework is based on the use of automatic feature selection techniques in both spatial and temporal dimensions as a pre-prediction stage. In this way, the proposed framework can improve the accuracy of other prediction schemes when using large amounts of data as input. The proposed scheme has been tested using different forecasting techniques. In addition, the impact of the proposed framework on predictions of different future lags has been analyzed.
Neural Correlates of Controlled Memory Processes in Questionable Alzheimer's Disease (2011)

Alzheimer's disease (AD) is characterized by a progressive loss of controlled cognitive processes (processes requiring mental effort and attentional resources), and functional neuroimaging at early stages of AD provides an opportunity to tease out the neural correlates of controlled processes. Controlled and automatic memory performance was assessed with the Process Dissociation Procedure in 50 patients diagnosed with questionable Alzheimer's disease (QAD). The patients&amp;apos; brain glucose metabolism was measured using FDG-PET. After a follow-up period of 36 months, 27 patients had converted to AD, while 23 remained stable. Both groups showed a similar decrease in controlled memory processes but preserved automatic processes at entry into the study, suggesting that impairment of controlled memory would not be specific for AD. Patients who subsequently converted to Alzheimer type dementia showed significantly decreased brain metabolism at baseline compared to stable QAD in associative cortices known to be involved in AD (the left precuneus, the right inferior parietal lobule and bilateral middle temporal cortex).Voxel-based cognitive and metabolic correlations showed that a decrease in controlled memory processes was preferentially correlated with lower activity in the dorsomedial prefrontal and posterior cingulate cortices in very early AD patients. The dorsomedial prefrontal cortex would play a role in controlled memory processes as they relate to reflective and monitoring processes, while the posterior cingulate cortex is involved in the controlled access to previously encoded episodes. In stable QAD patients, reduced controlled performance in verbal memory correlated with impaired activity in the left anterior hippocampal structure, which would alter the reactivation of associations created at encoding.
Exertional muscle injury: evaluation of concentric versus eccentric actions with serial MR imaging. (1991)

Eccentric muscular actions involve the forced lengthening or stretching of muscles and tend to produce exertional injuries. This study used magnetic resonance (MR) imaging to serially evaluate muscles in five healthy, untrained subjects who performed exhaustive biceps exercise by doing isolated eccentric and concentric actions with a dumbbell. Symptoms were assessed, and T2-weighted images of the arms were obtained before exercise and 1, 3, 5, 10, 25, 40, 50, 60, and 80 days after exercise. Statistically significant increases in T2 relaxation times indicative of muscle injury occurred on each day of MR imaging evaluation in muscles performing eccentric actions, peaking on day 3 in two subjects; day 5, two subjects; and day 10, one subject. The pattern and extent of the abnormalities on MR images were variable. Pain, soreness, and joint stiffness were present on days 1, 3, and 5 in muscles that performed eccentric actions. MR imaging showed subclinical abnormalities that lasted as long as 75 days after the disappearance of symptoms (two subjects). Muscles that performed concentric actions had no changes in T2 relaxation times and were asymptomatic throughout the study.
Adhesive and Long-range Capillary Forces Between Hydrophobic Surfaces in Water: Effects of Surface Topography (2009)

Interactions between a hydrophobic probe particle and surfaces with nanoscopic surface features have been investigated. Such surfaces were prepared by polishing or by spin-coating of nanoparticles. The surface topography was characterized by AFM, using the methods of high-resolution imaging, low-resolution imaging using the probe particle, and by the rolling ball method. The polished surfaces display sharp nanoscopic peaks and hardly any crevices. In contrast, the spin-coated surfaces can be characterized as nanostructured, due to the high density of nanoparticles that on a short length scale provides a regular pattern of crevices and hills. On all surfaces a larger waviness is also distinguished. In all cases the dominant force at short separations was found to be a capillary attraction due to the formation of an air/vapour condensate. Our data show that the large-scale waviness of the surface does not signiﬁcantly inﬂuence the range and magnitude of the capillary attraction, but large local variations in these quantities are found. The large variation in adhesion force corresponds to a small variation in local contact angle of the capillary condensate at the surfaces. The report discusses how the nature of the surface topographical features inﬂuences the capillary attraction by inﬂuencing the local contact angle and by pinning of the three phase contact line. The effect is clearly dependent on whether the surface features exist in the form of crevices or as extending ridges.
Magnetresonanz-Elastographie (2008)

Drug Prescribing for Patients with Chronic Kidney Disease in General Practice: a Cross-Sectional Study
Assessment of exercise capacity in women with type 2 diabetes (2008)

The primary aim of this study was to compare the maximal oxygen uptake as evaluated from a submaximal exercise test (EVO2peak) to direct measurements of VO2peak during a maximal exercise test as means of monitoring the aerobic endurance capacity in women with type 2 diabetes (T2D). Twenty-seven women with T2D participated in the study. The program consisted of combined group training 1 h twice a week during 12 weeks and walks 1 h per week. EVO2 max was estimated using a submaximal exercise test on a bicycle ergometer ad modum Astrand. VO2peak and maximal work rate were measured using an incremental maximal exercise test on an electrically braked bicycle ergometer at baseline and after 6 and 12 weeks. EVO2peak was higher than VO2peak at baseline and significantly higher at 12 weeks (EVO2peak1.92+/-0.54 l min(-1), VO2peak 1.41+/-0.36, P<0.005). Maximal work rate increased significantly after 12 weeks (12+/-15, P<0.005) compared to baseline. The main finding of this study was that EVO2peak assessed using a submaximal exercise test, systematically overestimated VO2peak. The combined group training increased maximal work rate but not VO2peak. This is likely to reflect peripheral adaptation to exercise and/or improved mechanical efficiency.
ChemInform Abstract: Heterogeneous Catalytic Asymmetric Dihydroxylation: Use of a Polymer‐ Bound Alkaloid. (1991)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Pd@Fe<sub>2</sub>O<sub>3</sub> Superparticles with Enhanced Peroxidase Activity by Solution Phase Epitaxial Growth (2016)

Compared to conventional deposition techniques for the epitaxial growth of metal oxide structures on a bulk metal substrate, wet-chemical synthesis based on a dispersible template offers advantages such as low cost, high throughput, and the capability to prepare metal/metal oxide nanostructures with controllable size and morphology. However, the synthesis of such organized multicomponent architectures is difficult because the size and morphology of the components are dictated by the interplay of interfacial strain and facet-specific reactivity. Here we show that solution-processable two-dimensional Pd nanotetrahedra and nanoplates can be used to direct the epitaxial growth of γ-Fe2O3 nanorods. The interfacial strain at the Pd−γ-Fe2O3 interface is minimized by the formation of an FexPd “buffer phase” facilitating the growth of the nanorods. The γ-Fe2O3 nanorods show a (111) orientation on the Pd(111) surface. Importantly, the Pd@γ-Fe2O3 hybrid nanomaterials exhibit enhanced peroxidase activity compared to that of isolated Fe2O3 nanorods with comparable surface area because of a synergistic effect for the charge separation and electron transport. The metal-templated epitaxial growth of nanostructures via wet-chemical reactions appears to be a promising strategy for the facile and high-yield synthesis of novel functional materials.