gebhart/patrepeval huggingface dataset:
Adaptive Selection of Cache Indexing Bits for Removing Conflict Misses (2014)

The design of cache memories is a crucial part of the design cycle of a modern processor, since they are able to bridge the performance gap between the processor and the memory. Unfortunately, caches with low degrees of associativity suffer a large amount of conflict misses. Although by increasing their associativity a significant fraction of these misses can be removed, this comes at a high cost in both power, area, and access time. In this work, we address the problem of high number of conflict misses in low-associative caches, by proposing an indexing policy that adaptively selects the bits from the block address used to index the cache. The basic premise of this work is that the non-uniformity in the set usage is caused by a poor selection of the indexing bits. Instead, by selecting at run time those bits that disperse the working set more evenly across the available sets, a large fraction of the conflict misses (85 percent, on average) can be removed. This leads to IPC improvements of 10.9 percent for the SPEC CPU2006 benchmark suite. By having less accesses in the L2 cache, our proposal also reduces the energy consumption of the cache hierarchy by 13.2 percent. These benefits come with a negligible area overhead.
Supplementary Data from Concordance of Genomic Alterations by Next-Generation Sequencing in Tumor Tissue versus Circulating Tumor DNA in Breast Cancer (2023)

&lt;p&gt;Supplemental Table 1. Genes and rearrangements studied; Supplemental Table 2: Genes added over time to Guardant360 assay; Supplemental Table 3. Defining concordance and partial concordance for a particular gene; Supplemental Table 4. Concordance and partial concordance among only genes with genomic alterations in either assay; Supplemental Table 5. Sensitivity, specificity, and diagnostic accuracy across 5 genes, including variants of unknown significance (VUS)&lt;/p&gt;
Current-mode rectifier with improved precision (1995)

A modified bridge bias arrangement is described for a precision current-mode rectifier that avoids the adjustment sensitivity of a previously reported scheme by directly defining diode bias current. In addition, an analysis of current-mode bridge rectification is presented, along with performance enhancements due to the introduction of a current summing output stage.
Emission-aware energy trading by coordinating thermal &amp;amp; wind power generation (2013)

In this work, combined trading of energy and emissions for coordinated wind and thermal units is considered. The objective is (a) to maximize the expected profits of the owner using coordination as risk mitigation and (b) to minimize emission. A two level mixed integer stochastic programming (SP) is used to handle various uncertainties. Simulation results show the benefits of using a combined bidding strategy for wind and thermal units along with emission reduction.
Processing of Nd—Fe—B Alloys by Inert Gas Atomization (1998)

Through a metallurgical approach to alloy design, advanced Nd-Fe-B alloys were developed which formed nanocrystalline composite microstructures after devitrification. Atomisation processing of these new alloys resulted in significant improvements in hard magnetic properties over previous alloys, allowing the possibility of high volume, low cost production by atomization methods.
Ambipolar Charge Transport in Isoindigo-Based Donor–Acceptor Polymers (2016)

A series of donor-acceptor isoindigo (iI)-based copolymers synthesized with increasing numbers of thiophene rings in the repeat unit (from zero to three thiophene rings, including silole and germole-bridged fused bithiophene units) is applied toward solution-processed OFET devices. Differential pulse voltammetry on thin films of the polymers recorded LUMO energy levels confined within a 0.1 eV range around 3.9 eV, while their bandgaps are estimated at 1.5 to 1.7 eV. The interchain π-stacking distance of each sample was evaluated from the 2D-WAXS diffraction patterns of annealed extruded filaments and the GIWAXS patterns of thin films, and were found to be all in the same range, between 3.65 and 3.75 Å for the thin films. Both p-type and n-type charge transport in thin film bottom gate, bottom contact transistor devices were recorded. In particular, the copolymer P(T-iI) containing one thiophene ring afforded well-balanced ambipolar p-type and n-type mobilities of 0.04 cm <sup>2</sup>/(V s) and 0.1 cm <sup>2</sup>/(V s), respectively. Under our processing conditions, the charge transport properties evolved from exclusively n-type to solely p-type as the number of thiophene rings within the repeat unit is increased to three rings in the case of P(T3-iI). This was observed despite all polymers displaying similar LUMO energy levels, interchain π-stacking distances, and microscopic thin film morphology (all face-on arrangement on the dielectric surface). This prompted a molecular-scale morphological analysis of P(T-iI) and P(T3-iI) in particular, using solid-state NMR spectroscopy in order to further investigate the stark difference in n-type mobilities between these two polymers. Using the complete assignment of solution 2D-NMR spectra of a thiophene-iI-thiophene model compound as guideline, the analysis of proton-carbon correlations in the solid-state 2D <sup>13</sup>C{ <sup>1</sup>H} FSLG-HETCOR NMR spectra of P(T-iI) and P(T3-iI) revealed differences in the molecular environment surrounding each iI unit. The latter suggests a stronger correlation of neighboring iI units in P(T-iI), whereas a stronger intermixing of iI and thiophenes prevails in P(T3-iI). We conclude that, in this study, the choice of the donor unit length within the primary structure of the D-A polymer can be responsible for hindering its n-type character.
Stem cell injection-induced glioneuronal lesion of the cauda equina (2018)

Commercial stem cell therapy and “stem cell tourism” refer to the for-profit industry that has recently experienced a rise in popularity due to the regenerative potential of pluripotent stem cells. Without regulatory oversight, there is a growing concern for the future of legitimate research into stem cell therapy due to exaggerated claims of potential benefit, which in turn can contribute to research misconduct and loss of scientific credibility.1 Associated morbidities such as stem cell-induced lesions are often not given adequate consideration. We present a case illustrating the development of a proliferative lesion after stem cell therapy with a unique morphologic pathology, illustrating this medical conundrum.
ChemInform Abstract: Inhibitors of Cholesterol Biosynthesis. Part 2. 3,5‐Dihydroxy‐7‐(N‐ pyrrolyl)‐6‐heptenoates, a Novel Series of HMG‐CoA Reductase Inhibitors. (1994)

Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Determination of the Extent of Protein Biotinylation by Fluorescence Binding Assay (1997)

A method was developed to determine the total amount of biotin present in biotinylated protein conjugates. Conjugates of bovine serum albumin, alkaline phosphatase, and horseradish peroxidase were used in this case study. The extent of biotinylation was determined by complete acid hydrolysis or by enzymatic digestion using proteinase K to release biotin from the biotinylated proteins, followed by sensitive detection of biotin using a coupled HPLC-binding assay system. This detection system is based on the enhancement of the fluorescence of streptavidin-FITC by biotin. The extent of biotinylation determined by this method was compared with the values obtained by a conventional colorimetric method that is based on the displacement of the dye 4-hydroxyazobenzene-2-carboxylic acid (HABA) from the binding sites of avidin. It was found that, because the described method determines the amount of liberated biotin after hydrolysis, it does not suffer from steric hindrance problems associated with the ability of biotin on a protein surface to displace HABA from avidin. Therefore, this method can provide a more accurate determination of the extent of biotinylation. It was also determined that the acid hydrolysis of the biotinylated protein was more effective in releasing the conjugated biotin compared to enzymatic digestion by proteinase K.
Vuvuzela (2013)

When scanning an actor's face in multiple static facial expressions, it is often desirable for the resulting scans to all have the same topology and for the textures to all be in the same UV space. Such "corresponded" scans would enable the straightforward creation of blendshape-based facial rigs. We present Vuvuzela, a semi-automated facial scan correspondence tool. Vuvuzela is currently being used in our facial rigging pipeline, and was one of the key tools in the Digital Ira project.
WE‐E‐105‐01: Managing and Leading Others: Practical Advice for Medical Physicists (2013)

Medical physicists often find themselves in management and leadership positions, whether they are direct supervisors of other physicists, students, and residents or indirect managers of tasks performed by professionals such as therapists, technologists or dosimitrists who report to someone else. Yet, many medical physicists have had no formal management training to be managers. Educational opportunities for developing this skill set may be limited to hospital‐wide human resources, informal training through mentorship, or on the job training without support. To address the unique needs of medical physicists, this session includes talks from a panel of physicists who are successful in managing others well. Each panelist will present tips and methods that they have learned or developed over their careers that have helped them succeed in managing others effectively. Each panelist will emphasize a different type of management: supervision of interdisciplinary groups (such as therapists and dosimetrists), direct reports for supervised physicists, (such as residents, junior physicists), and direct reports for academic activities (students, post‐doctoral associates). They may also share lessons they have learned from situations that were not handled well. Advice will include tips about managing students, residents, physicists and therapists. There will be a moderated question and answer session. Learning Objectives: 1. Learn about tools for improving your management skills for directly supervised physicists 2. Learn management skills for interdisciplinary groups 3. Learn management skills for supervision of students and/or post‐doctoral associates 4. Learn how to access other tools to become an effective manager
The Geldanamycin Derivative DMAG Demonstrates Improved Cytotoxicity and Down-Modulation of Hsp90 Client Proteins Relative to 17-AAG in Chronic Lymphocytic Leukemia (CLL) Cells: Justification for Clinical Trials in CLL. (2006)

Abstract The heat shock protein Hsp90 functions to stabilize important cell survival- and proliferation-related kinases such as AKT, IKK, c-Src, Raf-1, and cdk9. Cancer cells have activated Hsp90 as compared to normal cells, making this a relevant therapeutic target to eliminate these kinases. The semi-synthetic geldanamycin derivative 17-allylamino-17-demethoxygeldanamycin (17-AAG) binds to and inhibits the activity of Hsp90, and previous work demonstrated the ability of 17-AAG to deplete AKT in several cancer types in vitro. A newer geldanamycin derivative, 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (DMAG) has improved pharmacological properties including solubility and oral bioavailability, and was shown to be more effective than 17-AAG in melanoma and pancreatic carcinoma mouse xenograft mouse models. We therefore examined the effects of 17-AAG and DMAG against CD19-positive tumor cells from CLL patients. Cell viability was examined by the MTT assay, and AKT and IKK protein expression was examined by immunoblot analysis. In samples from seven CLL patients, 1.0uM DMAG resulted in 31.5% viability (95% CI: 13.1–50.0%), compared to 61.5% viability (95% CI: 45.0–78.0%) using the same concentration of 17-AAG. In four CLL patient samples treated with 1.0uM DMAG for 24 hours, AKT was decreased an average of 72.5% (95% CI: 57.7–87.3%) relative to the untreated controls. This is in comparison to 1.0uM 17-AAG, which caused a 52.7% decrease in AKT (95%CI: 39.7–65.6%). IKK protein was also decreased at similar levels in all patient samples examined. This data indicates that in CLL cells, DMAG has superior activity both in cytotoxicity and in reduction of relevant Hsp90 client proteins. 17-AAG is currently undergoing Phase I clinical testing in CLL, and DMAG is completing phase I clinical development in solid tumor malignancies. Overall, our data and that of others support clinical development of DMAG in CLL, based on the improved pharmacologic properties, enhanced efficacy relative to 17-AAG, and expected down-regulation of target proteins. In addition, our in vitro observations support using measurement of protein down-regulation of AKT and IKK as pharmacodynamic biomarkers of activity in patients undergoing therapy with these agents.
Hosting Virtual Machines on Distributed Datacenters (2016)

Almost of cloud services nowadays are built at top geographically distributed infrastructure for better reliability and performance. These cloud providers need an efficient method to control and direct user workload to suitable datacenter, depending on many factors such as: network traffic cost, operation cost budget, energy consumption, etc. In the virtual machine placement problem, current works mainly focus on the efficiency of packing virtual machines into servers and ignore the distributed scenario of datacenters. In this paper, we consider the problem of placing virtual machines to host applications on a shared resource pool based on distributed cloud platforms. We formulate the problem of hosting virtual machines on distributed datacenters as an optimization problem, and propose a distributed framework DHC that can dynamically direct workload between datacenters to maximize total utility of entire datacenters. We also conduct many case studies to validate our method, and evaluate its effectiveness and practicality, using real-workload traffic traces. The simulation results show that our algorithm can dynamically optimize the total utility, depending on various workload of users.
Relationship between tissue factor expression and deposition of fibrin, platelets, and leukocytes on cultured endothelial cells under venous blood flow conditions (1993)

Endothelial cell-mediated coagulation and leukocyte adhesion are processes that might be connected by the generation of thrombin. To examine the interaction of procoagulant and proadhesive activity, cultures of endothelial cells were stimulated with tumor necrosis factor-alpha, which resulted in the surface expression of tissue factor. Subsequent exposure to human nonanticoagulated blood at a shear rate of 100 s-1 in a parallel plate perfusion device led to the deposition of polymerized fibrin, which covered 63% of the endothelial surface. In addition, numerous platelet aggregates (71 per 10 mm cross- section) and leukocytes (53 +/- 6/mm2) were deposited on stimulated endothelial cells, whereas no fibrin and only a few platelet aggregates (4 +/- 1 per 10 mm cross-section) and leukocytes (6 +/- 1/mm2) were detected on control cells. A significant portion of the adherent leukocytes bound to fibrin and platelets. However, when the deposition of fibrin and platelet aggregates was inhibited with the anti-tissue factor antibody HTFI-7B8 by 100% and 86%, respectively, leukocyte adherence remained unchanged (68 +/- 6/mm2). This indicated that leukocytes could efficiently adhere to endothelial cells through direct cell-cell contact independent of both thrombin and deposited fibrin. Moreover, this direct adhesion of leukocytes to the endothelial surface was reduced twofold to threefold when fibrin deposition occurred. These data suggest a relationship between endothelial procoagulant and proadhesive properties in that tissue factor-initiated coagulation may contribute to leukocyte adhesion through the formation of an adhesive fibrin/platelet meshwork but concurrently prevents the adhesive endothelial surface to bind leukocytes at its full capacity.
Can Sustainable Packaging Help to Reduce Food Waste? A Status Quo Focusing Plant-derived Polymers and Additives (2021)

Abstract: The promotion of sustainable packaging is part of the European Green Deal and plays a key role in the EU&amp;rsquo;s social and political strategy. One option is the use of renewable resources and biomass waste as raw materials for polymer production. Lignocellulose biomass from annual and perennial industrial crops and agricultural residues are a major source of polysaccharides, proteins, and lignin, and can also be used to obtain plant-based extracts and essential oils. Therefore, these biomasses are considered as potential substitute for fossil-based resources. Here, the status quo of bio-based polymers is discussed and evaluated in terms of properties related to packaging applications such as gas and water vapor permeability as well as mechanical properties. So far, their practical use is still restricted due to lower performance in fundamental packaging functions that directly influence food quality and safety, the length of shelf life and thus the amount of food waste. Besides bio-based polymers, this review focuses on plant extracts as active packaging agents. Incorporating extracts of herbs, flowers, trees, and their fruits is inevitable to achieve desired material properties that are capable to prolong the food shelf life. Finally, the adoption potential of packaging based on polymers from renewable resources is discussed from a bioeconomy perspective.
Immunosuppression and risk of cervical cancer (2012)

A markedly increased risk of cervical cancer is known in women immunosuppressed due to AIDS or therapy following organ transplantation. The aim of this review is to determine the association between other conditions affecting the immune system and the risk of cervical cancer. Patients with end-stage renal disease seem to be at an increased risk of cervical cancer. A higher risk of cervical precancerous lesions was found in patients with some autoimmune diseases; particularly if treated with immunosuppressants. Among behavioral factors weakening the immune system, smoking appeared to strongly increase the risk of cervical cancer, while poor diet only moderately increased the risk. It is difficult to determine whether sexually transmitted infections other than human papillomavirus infection are independent risk factors. Identifying those groups of women likely to fail in clearing persistent human papillomavirus infections would help individualize screening guidelines and target immune-associated factors in the cervical cancer etiology.
Low cost tactile gripper using silicone rubber sensor array (1988)

SUMMARY A low cost tactile sensor using commercially available conductive silicone rubber has been developed. It comprises a two dimensional array arranged in 3 mm centre-to-centre distance. Each sensor element has a zero-force resistance of about 0.3 kohm and it has a logarithmic characteristic curve of resistance versus force. An 8 × 8 prototype tactile sensor array over an area of 3 cm × 3 cm has been fabricated and mounted on the gripper of a robot for testing and evaluation. The associated software has also been developed. The limitations of the sensor are also discussed.
A Dual-Linear Polarization VHF Probe for Spherical Near-Field Measurement Based on a Wideband Superdirective Antenna Array (2023)

This paper presents the analysis and design of a dual-linear polarized VHF antenna based on a superdirective parasitic array of three magneto-electric antennas. The proposed antenna has been designed to work as a compact VHF near-field probe in CNES measurement facilities. The optimization process is detailed with a focus on maximizing the operating bandwidth. The proposed antenna exhibits superdirective properties over a 9% fractional bandwidth.
Estimation of the deprotonation degree of phenolic groups on kraft lignin (2015)

Lignin is an abundant biomaterial, with potential as raw material feed stock for production of solid- and liquid fuels as well as phenolic components and carbon fibres. Lignin may be separated from various process streams in an integrated pulp production and wood-based biorefinery. Separation of Kraft lignin from black liquor can be made by the LignoBoost technology; it starts with precipitation of lignin by acidification of the black liquor and consequently protonation of the phenolic groups on lignin, in equilibrium with the surrounding liquid. The protonation degree of phenolic groups on kraft lignin has been identified as a key-property in controlling the precipitation yield. It has been investigated if the protonation degree of lignin in a black liquor system can be modelled using a modified Poisson-Boltzmann cell model which has been combined with the Pitzer method. It was found that the model gave reasonable results. Furthermore, the model indicated that the protonation degree is strongly dependent on the pH and temperature of the black liquor, however, the molecular weight of lignin has a minor influence and at the high ionic strength in black liquor a small change in ionic strength has only a very small influence on the protonation. Additionally, the predicted deprotonation degrees were compared with previously measured precipitation degrees at industrially relevant conditions.
iHelp: Techniques for early risk identification, predictions and assessment I (2021)

This report summarizes the actions performed under Task 5.1 - “Techniques for early risk identification, predictions and assessment I” and more specifically provides details of the Artificial Intelligence (AI) / Machine Learning (ML) algorithms and implementation techniques that will be used to perform early identification as well as predictions of Pancreatic Cancer (PC) risks in individuals. The deliverable brings together several AI/ML techniques that are expected to be able to identify hidden patterns and trends in given data. When the data become available in the next phase of the project, these techniques will be used for performing assessment of identified risks and subsequently for making predictions. Since this is the first version of a series of deliverables, the follow-up report (i.e. D5.2) will specify the techniques to be used and linked with the datasets collected from the project pilots.
Access and mobility of wireless PDA users (2005)

In this paper, we analyze the mobility patterns of users of wireless hand-held PDAs in a campus wireless network using an eleven week trace of wireless network activity. Our study has two goals. First, we characterize the high-level mobility and access patterns of hand-held PDA users and compare these characteristics to previous workload mobility studies focused on laptop users. Second, we develop two wireless network topology models for use in wireless mobility studies: an evolutionary topology model based on user proximity and a campus waypoint model that serves as a trace-based complement to the random waypoint model. We use our evolutionary topology model as a case study for preliminary evaluation of three ad hoc routing algorithms on the network topologies created by the access and mobility patterns of users of modern wireless PDAs. Based upon the mobility characteristics of our trace-based campus waypoint model, we find that commonly parameterized synthetic mobility models have overly aggressive mobility characteristics for scenarios where user movement is limited to walking. Mobility characteristics based on realistic models can have significant implications for evaluating systems designed for mobility. When evaluated using our evolutionary topology model, for example, popular ad hoc routing protocols were very successful at adapting to user mobility, and user mobility was not a key factor in their performance.