gebhart/patrepeval huggingface dataset:
The Aryl Hydrocarbon Receptor–Dependent TGF-α/VEGF-B Ratio Correlates With Disease Subtype and Prognosis in Multiple Sclerosis (2021)

This study provides Class III evidence that serum levels of AHR, TGF-α, and VEGF-B distinguish subtypes of MS and predict the severity and disease activity of MS.
Comparison of 2 Different Tumor Cell Labeling Techniques for in Vitro MRI Characterization with New Iron Oxide Particles (2008)

Iron oxide particles (SPIO and USPIO) are widely used for MRI-based cell labeling and tracking because they can be loaded on cells by simple protocols and provide high image contrast due to their large susceptibility effect. We compared 2 different cell labeling models (AGAR and Ficoll) in human KB cells. Both presented cell labeling methods (AGAR and Ficoll model) are feasible for in vitro MR characterization of KB tumor cells at 1.5, 2.35 and 3T. Ficoll method is easier to perform because it does not need a heating procedure for preparation without air bubbles as compared to AGAR method.
Réseau linéaire et non linéaire d'ordre deux dans des verres "polés" induit par absorption deux photons (2000)

International audience
[Head and neck cancer treatment in the elderly]. (2015)

We compared the treatment modalities as well as the oncologic outcome between young elderly (65-79 years old), elderly (>80 years old) and the reference population (<65 years old.) We reviewed 1047 patients treated between 2002 and 2012. Tumor sites, TNM stages, type of treatment, and the oncologic results are compared with survival statistics. The elderly group was associated with an increase in palliative treatment, more women and advanced T stages. For the 947 patients treated with curative intent, 5 year recurrence free survival was comparable. The overall-survival decreases with the age because of intercurrent deaths. Nevertheless, the treatment efficacy is similar. In conclusion, an advanced age is associated with worse survival, without a decrease in loco-regional control. The chronological age should not be used as a predictive factor for treatment response.
Effects of property ordering in an incremental formal modeling methodology (2004)

In this paper, we analyze the effect of ordering linear time properties while using the Extreme Formal Modeling (XFM) methodology in building "prescriptive formal models" (PFM). PFMs are formal models built incrementally by adding user stories and are used as specification golden models. In our methodology, the user stories are captured in Linear Time Temporal Logic (LTL). A more expressive logic or formalism could be used for describing the user stories as well. During incremental model building, the PFMs often blow up in size in terms of the state space, and the main tenet of XFM being regressive model checking, blown up models often make it impossible to carry out the XFM methodology. Here, we propose property ordering hueristics to circumvent this problem. We compare these hueristics with: (i) no specific ordering of user stories (standard approach), (ii) sorting of the user stories based on a weighting scheme (property based sorting), and (Hi) predicate based sorting of user stories based on an eliminative scheme (predicate based sorting). We show that the predicate based sorting scheme is the most effective way to carry-out XFM model building. We illustrate the schemes and the comparison by modeling a monitor for the ISA bus and for the arbitration phase of Pentium Pro processor's bus using the Cadence SMV. We also provide an algorithm for the predicate based sorting that yields the best control on the increments in model size.
Double Pedicle Screw Instrumentation in the Osteoporotic Spine (2007)

The double-screw construct appears feasible and safe in the thoracolumbar spine. In this study, the new technique demonstrates a mechanical advantage over the standard single-screw technique. Further in vitro cadaveric safety studies with better adapted instrumentation are needed before the technique can be widely recommended.
A chemical probe unravels the reactive proteome of health-associated catechols (2023)

Catechol-containing natural products are common constituents of foods, drinks, and drugs. Natural products carrying this motif are often associated with beneficial biological effects such as anticancer activity and neuroprotection. However, the molecular mode of action behind these properties is poorly understood. Here, we apply a mass spectrometry-based competitive chemical proteomics approach to elucidate the target scope of catechol-containing bioactive molecules from diverse foods and drugs. Inspired by the protein reactivity of catecholamine neurotransmitters, we designed and synthesised a broadly reactive minimalist catechol chemical probe based on dopamine. Initial labelling experiments in live human cells demonstrated broad protein binding by the probe, which was largely outcompeted by its parent compound dopamine. Next, we investigated the competition profile of a selection of biologically relevant catechol-containing substances. With this approach, we characterised the protein reactivity and the target scope of dopamine and ten biologically relevant catechols. Strikingly, proteins associated with the endoplasmic reticulum (ER) were among the main targets. ER stress assays in the presence of reactive catechols revealed an activation of the unfolded protein response (UPR). The UPR is highly relevant in oncology and cellular resilience, which may provide an explanation of the health-promoting effects attributed to many catechol-containing natural products.
Cross-Domain Features of Runs of Genetic Programming Used to Evolve Designs for Analog Circuits, Optical Lens Systems, Controllers, Antennas, Mechanical Systems, and Quantum Computing Circuits (2006)

Genetic programming has now been successfully used to automatically synthesize human-competitive designs in a number of fields, including analog electrical circuits, optical lens systems, antennas, controllers, mechanical systems, and quantum computing circuits. Despite considerable variation in representation and technique, the above results share a number of common features. This paper identifies five common features and suggests possible explanations and interpretations for them. Some of these cross-domain observations clearly could not have been anticipated prior to the work being done.
A data set providing synthetic and real-world fisheye video sequences (2016)

In video surveillance as well as automotive applications, so-called fisheye cameras are often employed to capture a very wide angle of view. As such cameras depend on projections quite different from the classical perspective projection, the resulting fisheye image and video data correspondingly exhibits non-rectilinear image characteristics. Typical image and video processing algorithms, however, are not designed for these fisheye characteristics. To be able to develop and evaluate algorithms specifically adapted to fisheye images and videos, a corresponding test data set is therefore introduced in this paper. The first of those sequences were generated during the authors' own work on motion estimation for fish-eye videos and further sequences have gradually been added to create a more extensive collection. The data set now comprises synthetically generated fisheye sequences, ranging from simple patterns to more complex scenes, as well as fisheye video sequences captured with an actual fisheye camera. For the synthetic sequences, exact information on the lens employed is available, thus facilitating both verification and evaluation of any adapted algorithms. For the real-world sequences, we provide calibration data as well as the settings used during acquisition. The sequences are freely available via www.lms.lnt.de/fisheyedataset/.
Consensus Control for Energy Storage Systems (2016)

In this paper, consensus integral control is applied for energy storage in microgrids to synchronize the state-of-charge (SoC) and power levels of batteries with limited information exchange. Both local information (SoC and power level) and neighbors' information (SoC and power level) will be fed into an integral control installed at every battery converter. The design is based on consensus control and takes into consideration of real-world battery coordination requirements, e.g., all batteries should work in the same charging or discharging mode. Compared with the consensus control in the existing literature for voltage consensus or battery SoC/power consensus, this paper offers a simple design. The major assumption of this paper is that each converter should possess an integral control. This assumption is valid since indeed integral controls exist if converters are equipped with secondary frequency control. The designed consensus control is validated by simulations on 14-bus microgrid and IEEE 57-bus power system. Simulation results demonstrate the effectiveness of the consensus integral control for variety modes of operation: 1) charging; 2) discharging; and 3) load variation.
Rat Strain Differences in Susceptibility to Alcohol-Induced Chronic Liver Injury and Hepatic Insulin Resistance (2010)

The finding of more severe steatohepatitis in alcohol fed Long Evans (LE) compared with Sprague Dawley (SD) and Fisher 344 (FS) rats prompted us to determine whether host factors related to alcohol metabolism, inflammation, and insulin/IGF signaling predict proneness to alcohol-mediated liver injury. Adult FS, SD, and LE rats were fed liquid diets containing 0% or 37% (calories) ethanol for 8 weeks. Among controls, LE rats had significantly higher ALT and reduced GAPDH relative to SD and FS rats. Among ethanol-fed rats, despite similar blood alcohol levels, LE rats had more pronounced steatohepatitis and fibrosis, higher levels of ALT, DNA damage, pro-inflammatory cytokines, ADH, ALDH, catalase, GFAP, desmin, and collagen expression, and reduced insulin receptor binding relative to FS rats. Ethanol-exposed SD rats had intermediate degrees of steatohepatitis, increased ALT, ADH and profibrogenesis gene expression, and suppressed insulin receptor binding and GAPDH expression, while pro-inflammatory cytokines were similarly increased as in LE rats. Ethanol feeding in FS rats only reduced IL-6, ALDH1-3, CYP2E1, and GAPDH expression in liver. In conclusion, susceptibility to chronic steatohepatitis may be driven by factors related to efficiency of ethanol metabolism and degree to which ethanol exposure causes hepatic insulin resistance and cytokine activation.
The joint <i>in vitro</i> action of polymyxin <scp>B</scp> and miconazole against pathogens associated with canine otitis externa from three <scp>E</scp>uropean countries (2013)

In vitro synergy of polymyxin B and miconazole against E. coli and P. aeruginosa isolates indicates a rationale for applying both agents in combination to treat otitis externa when infected with these types of bacteria.
Overview of lung surfactant and respiratory distress syndrome (2019)

Pulmonary surfactant (PS) is a phospholipid-protein complex that lines the airways as a monomolecular layer of only a few nanometers. PS aides in gas exchange and reduce surface tension in the alveoli to prevent airway collapse. Alveolar stability depends on lung surfactant surface tension variability and its ability to reach low surface tension. Pulmonary surfactant replacement therapy has offered animal-derived surfactants as well as synthetic surfactants. Lung surfactant replacement therapeutics has included synthetic phospholipid colloidal dispersions, animal lung surfactant extracts, and recombinant human surfactant peptides. Lung surfactant replacement therapeutics can also be aerosolized provided the appropriate interactions between the formulation and specific inhaler device are optimized. There is much research interest in using lung surfactant replacement-mimic formulations as inhaled carriers of drugs given the unique spreading and aerosol properties of these advanced formulations. Since many drugs are surface-active and/or hydrophobic, lung surfactant carriers can efficiently encapsulate them as carrier systems.
DECOMPOSITION OF MULTIMODAL DATA FOR AFFORDANCE-BASED IDENTIFICATION OF POTENTIAL GRASPS (2012)

In this paper, we apply standard decomposition approaches to the problem of finding local correlations in multi-modal and high-dimensional grasping data, particularly to correlate the local shape of cup-like objects to their associated local grasp configurations. We compare the capability of several decomposition methods to establish these task-relevant, inter-modal correlations and indicate how they can be exploited to find potential contact points and hand postures for novel, though similar, objects. 1
CW, High Power, Single-Longitudinal-Mode Operation of an Optically Pumped Mid-IR DFB Laser (2007)

A CW, single-longitudinal-mode, optically pumped mid-IR distributed-feedback antimonide-based type-II quantum-well laser at 3.62 μm is demonstrated. Record high output powers, > 300 mW per side, and tunability of 5.5 nm are obtained at 77 K.
Dynamic HPLC: A Method for Determining Rate Constants, Energy Barriers, and Equilibrium Constants of Molecular Dynamic Processes (1991)

Abstract For corrigendum see DOI: 10.1002/anie.199102161
Ultrashort Pulsed Laser Surface Patterning of Titanium to Improve Osseointegration of Dental Implants (2019)

Ultrashort pulsed direct laser interference patterning (DLIP) is used to generate hierarchical line‐like patterns on titanium surfaces to control cell adhesion and spreading on dental implants, thereby improving osseointegration. The DLIP structures have spatial periods of 3, 5, 10, and 17 μm. They are produced using a laser source with a pulse duration of 10 ps and cumulated energy densities between 0.1 and 78.9 J cm −2 . Laser‐induced periodic surface structures (LIPSS) and submicron features are obtained on the treated samples. The DLIP treatment leads to the development of a thick titanium oxide layer, which is imaged and quantified using time‐of‐flight secondary ion mass spectrometry (ToF‐SIMS). Several days (30–56) after the laser treatment, specimens with larger spatial periods are hydrophilic, whereas samples with spatial periods of 3 μm are hydrophobic. Seeded human osteoblasts on the laser‐structured samples show 2.5 times higher cell numbers after 7 days in vitro culture compared with osteoblasts on a grit‐blasted and etched reference sample. Finally, cell adhesion to a structured 3D dental implant is demonstrated.
Data from Gene Expression Profiles in Pancreatic Intraepithelial Neoplasia Reflect the Effects of Hedgehog Signaling on Pancreatic Ductal Epithelial Cells (2023)

&lt;div&gt;Abstract&lt;p&gt;Invasive pancreatic cancer is thought to develop through a series of noninvasive duct lesions known as pancreatic intraepithelial neoplasia (PanIN). We used cDNA microarrays interrogating 15,000 transcripts to identify 49 genes that were differentially expressed in microdissected early PanIN lesions (PanIN-1B/2) compared with microdissected normal duct epithelium. In this analysis, a cluster of extrapancreatic foregut markers, including &lt;i&gt;pepsinogen C&lt;/i&gt;, &lt;i&gt;MUC6&lt;/i&gt;, &lt;i&gt;KLF4&lt;/i&gt;, and &lt;i&gt;TFF1&lt;/i&gt;, was found to be up-regulated in PanIN. Up-regulation of these genes was further validated using combinations of real-time reverse transcription-PCR, &lt;i&gt;in situ&lt;/i&gt; hybridization, and immunohistochemistry in a total of 150 early PanIN lesions from 81 patients. Identification of these gastrointestinal transcripts in human PanIN prompted assessment of other foregut markers by both semiquantitative and real-time reverse transcription-PCR, revealing similar up-regulation of Sox-2, Gastrin, HoxA5, GATA4/5/6, Villin and Forkhead 6 (Foxl1). In contrast to frequent expression of multiple gastric epithelial markers, the intestinal markers intestinal fatty acid binding protein, CDX1 and CDX2 were rarely expressed either in PanIN lesions or in invasive pancreatic cancer. Hedgehog pathway activation induced by transfection of immortalized human pancreatic ductal epithelial cells with Gli1 resulted in up-regulation of the majority of foregut markers seen in early PanIN lesions. These data show frequent up-regulation of foregut markers in early PanIN lesions and suggest that PanIN development may involve Hedgehog-mediated conversion to a gastric epithelial differentiation program.&lt;/p&gt;&lt;/div&gt;
INCORPORATING FEATURE RANKING AND EVOLUTIONARY METHODS FOR THE CLASSIFICATION OF HIGH-DIMENSIONAL DNA MICROARRAY GENE EXPRESSION DATA (2013)

DNA microarray gene expression classification poses a challenging task to the machine learning domain. Typically, the dimensionality of gene expression data sets could go from several thousands to over 10,000 genes. A potential solution to this issue is using feature selection to reduce the dimensionality.
Broadband Emission in Quantum-Dash Semiconductor Laser (2010)

The first mid-infrared broadband semiconductor laser was demonstrated in an intersubband structure by adopting a quantum cascade configuration Laser action with a Fabry-Perot spectrum covering all wavelengths from 6 to 8 m simultaneously is demonstrated with a number of dissimilar intersubband optical transitions. Recently, similar unique spectral properties in the form of quasi-supercontinuum lasing characteristics have been demonstrated on semiconductor quantum-dot (Qdot) and Qdash platforms in different near-infrared wavelength regime without the need of ultrashort pulse laser excitation or the engineering of the intersubband transition level. ( a Djie et al., 2007; Kovsh et al., 2007 ; b Djie et al., 2007; Tan et al., 2008). Most important, this unique feature of quasi-supercontinuum emission occurs at high temperature, i.e. room temperature in addition to identical operating conditions of a conventional semiconductor lasers. Owing to its broad and continuous spectrum emitted via only a single semiconductor laser diode, such device is called broadband laser. The broadband laser technology utilizes largely inhomogeneous quantum nanostructures active medium such as quantum-dot (Qdot) structures for wavelength emission in ~1200 nm ( a Djie et al., 2007 Bandgap tuning with emission width widening is possible and can be realized in Qdash materials via postgrowth lattice interdiffusion technique Furthermore, interband optical transition in quantum confined heterostructures will contribute to a highly efficient broadband laser action as compared to other emitter technologies.
Designing neutral coordination networks with the aid of hydrogen bond mimicry using silver(<scp>i</scp>) carboxylates (2002)

Parallels can be drawn between the structural chemistry of carboxylic acids and that of silver(I) carboxylates in which ‘Ag+ ions’ in the latter replace ‘H+ ions’ in the former. Both form ring and tape arrangements, which can be used effectively in crystal engineering to construct neutral networks. Silver(I) carboxylates, however, have the additional capacity to coordinate further ligands. Here we describe a series of network structures developed using a secondary building unit (SBU) based upon the carboxylate-bridged Ag2 dimer, ‘Ag2(CF3CO2)2L4’, where L is a neutral ditopic ligand. Use of L = 1,4-diazabicyclooctane, piperazine, or each of five different pyrazine derivatives leads to closely related lamellar structures of composition Ag2(CF3CO2)2L2, which have been characterized by single crystal X-ray diffraction and whose bulk composition has been examined by elemental analysis and powder diffraction. The versatility and reliability of the silver(I) carboxylate linkage is also examined and compared with that of supramolecular synthons known for carboxylic acid building blocks.
Resonances of Discrete Systems Close to NNMs (1996)

This chapter contains sections titled: Exact Steady State Motions Admissible Forcing Functions for Steady State Motions Effects of NNM Bifurcations on the Resonances
Haptics, Instrumentation, and Simulation: Technologies for Enhanced Hand Drilling Training (1999)

&lt;div class="section abstract"&gt;&lt;div class="htmlview paragraph"&gt;A fundamental part of airplane manufacturing involves hand drilling of holes for fasteners (bolts and rivets). The integrity of a fastener depends on the quality of its hole, which must be properly positioned, have a circular diameter of correct dimension, and be free of surface flaws and contaminants. A common method of drilling training is for a student to drill holes under the supervision of an instructor who inspects or measures the holes and makes suggestions for improving technique. This training method has proven to be effective, but it is time-consuming and requires considerable personal attention. We have devised instrumentation to monitor critical parameters (drill orientation and forces) so that a student can receive instantaneous visual feedback. This real-time feedback provides the student a better understanding of the drilling process and allows him or her to quickly make improvements. We have also developed a simulation of the drilling process that includes three-dimensional (3D) visualization and haptics force feedback. We propose to couple the instrumented drill training aid and the haptics simulation with traditional training methods to achieve faster learning, more complete understanding, and a higher skill level.&lt;/div&gt;&lt;/div&gt;
Direct focal spot adaptive optics for achieving high power diffraction limited performance in the interaction chamber (2013)

In order to reach the highest intensity of the focal spot, short focal length focusing optics are used in most of today’s laser facilities. These optics usually degrade significantly the wavefront quality of the laser and so the focal spot quality. We present focal spots corrected from the focusing optics aberration thanks to direct focal spot adaptive optics. Diffraction limited performance of the laser system is achieved for the final focal spot at high power in the interaction chamber.
UWB material characterisation and object recognition with applications in fire and security (2008)

By means of UWB radar sensors the tasks of material characterisation and object recognition are performed on the basis of a previous imaging of the whole environment. A UWB version of the microwave ellipsometry method is applied for estimating the permittivity of homogenous objects. The object recognition task is performed using bistatic sensor nodes on the basis of Radar measurements. The simulation-based performance evaluations show a very robust behavior due to suitable pre-processing of Radar data. The applications comprise the detection of fire sources, the detection of metallic object hidden under clothing and the recognition of building structures.
A Stereo and Color-based Method for Face Pose Estimation and Facial Feature Extraction (2006)

This paper describes a method to perform face pose estimation and high resolution facial feature extraction on the basis of stereoscopic color images. Unlike other approaches no light projection is required at running time. In our method face detection is based on color driven clustering of 3D points derived from stereo. A mesh model is registered with the post-processed face cluster using a variant of the iterative closest point algorithm (ICP). Pose is derived from correspondence. Then, pose and model information is used for face normalization and facial feature localization. Results show, stereo and color are powerful cues for finding the face and its pose under a wide range of poses, illuminations and expressions (PIE). Head orientation may vary in out of plane rotations up to plusmn45deg