gebhart/patrepeval huggingface dataset:
Correlation between anti-S IgG and neutralizing antibody titers against three live SARS-CoV-2 variants in BNT162b2 vaccine recipients (2022)

We analyzed serially collected serum samples from healthy adults who underwent BNT162b2 vaccination to elucidate the association between spike (S)-IgG antibody titers determined by ELISA using the WHO international standard (NIBSC code 20/136) and neutralizing antibody titers against three live SARS-CoV-2 variants. This study included 53 health care workers who received two doses of the BNT162b2 vaccine. S-IgG and nucleocapsid (N)-IgG antibody titers were measured by ELISA. Neutralizing (NT) antibody responses against three variants (Wuhan D614 G: KUH003, Alpha, and Delta) were evaluated before and after the first and second vaccination. <i>N</i>-IgG were not detected in any serum samples. S-IgG antibody titers remarkably increased after two BNT162b2 vaccine doses in all participants. S-IgG antibody titers were strongly correlated with NT titers against three variants of live viruses: KUH003 (r = 0.86), Alpha (r = 0.72), and Delta (r = 0.84). Serum samples from participants after one dose of BNT162b2 neutralized Alpha efficiently (median titer, 113.0), but median NT titers against KUH003 and Delta variants were lower, 57.0 and 28.0, respectively (<i>p</i> < .01). Two doses of the BNT162b2 vaccine elicited a strong immune response in this study. The second dose was required for induction of a strong booster effect. Serum collected from BNT162b2 vaccine recipients contained significantly lower neutralizing activity against Delta than that of against KUH003 (<i>p</i> < .0001) and Alpha (<i>p</i> < .0001). If a new variant emerges, live virus-based NT titers should be examined in serum obtained from vaccine recipients to evaluate vaccine efficacy for protection against infection.
GraphConnect: A Regularization Framework for Neural Networks (2015)

Deep neural networks have proved very successful in domains where large training sets are available, but when the number of training samples is small, their performance suffers from overfitting. Prior methods of reducing overfitting such as weight decay, Dropout and DropConnect are data-independent. This paper proposes a new method, GraphConnect, that is data-dependent, and is motivated by the observation that data of interest lie close to a manifold. The new method encourages the relationships between the learned decisions to resemble a graph representing the manifold structure. Essentially GraphConnect is designed to learn attributes that are present in data samples in contrast to weight decay, Dropout and DropConnect which are simply designed to make it more difficult to fit to random error or noise. Empirical Rademacher complexity is used to connect the generalization error of the neural network to spectral properties of the graph learned from the input data. This framework is used to show that GraphConnect is superior to weight decay. Experimental results on several benchmark datasets validate the theoretical analysis, and show that when the number of training samples is small, GraphConnect is able to significantly improve performance over weight decay.
Multi-particle Auger dissociation of excitons in shallow doped carbon nanotubes (2011)

Shallow hole-doping in small diameter single-wall carbon nanotubes by H$_2$O$_2$ is shown to result in delocalized excited state quenching with no effects on the ground state absorption spectrum. To account for this process, the dissociation of excitons by shallow level electronic impurities is predicted to occur by multi-particle Auger decay. This mechanism, which relies on the chirality of the electronic states, causes the exciton to decay into electron-hole pairs with very high efficiencies.
Fractional sampling OFCDM with alternative spreading code (2008)

Orthogonal frequency and code division multiplexing (OFCDM) has received large attention as a modulation scheme to realize high data rate transmission. In this paper, the OFCDM system with fractional sampling (FS) is investigated. FS is a diversity scheme with a single antenna, which achieves path diversity through oversampling and parallel signal reception. However, the correlation among noise components may deteriorate the bit error rate (BER) performance at the receiver as the number of subcarriers and oversampling ratio increase. To overcome this problem, the alternative spreading code is used for the FS OFCDM system. Numerical results through computer simulation show that the proposed scheme can improve the performance of the receiver with the large oversampling ratio and the number of subcarriers.
Endocytic Properties of the M-type 180-kDa Receptor for Secretory Phospholipases A2 (1996)

Endocytic properties of the M-type 180-kDa receptor for secretory phospholipases A2 (sPLA2) were first investigated in rabbit myocytes that express it at high levels. Internalization of the receptor was shown to be clathrin-coated pit-mediated, rapid (ke = 0.1 min-1), and ligand-independent. The signal sequence for internalization was then identified upon transient and stable expression of various receptor constructs with mutated cytoplasmic sequences. Analysis of the internalization efficiency of the mutants suggested that the NSYY motif encodes the major endocytic signal, with the distal tyrosine residue playing the key role. Amino acid substitutions at the putative casein kinase II phosphorylation site of the receptor did not affect internalization. A chimeric protein composed of the extracellular and transmembrane domains of the rabbit sPLA2 receptor and of the cytoplasmic domain of the structurally homologous human macrophage mannose receptor retained the high affinity for sPLA2 and was internalization competent, exhibiting 50% endocytic activity of the M-type sPLA2 receptor. The results indicate the compatibility of the structural domains of the two parent proteins and provide evidence for the interchangeable character of their internalization signals.
Three-dimensional analysis of prebunched electron beams in an x-ray free-electron laser (2012)

The effect of partial prebunching of an electron beam on the saturation length, efficiency, and longitudinal coherence is studied for a nominal x-ray free-electron laser design. Results indicate that partial prebunching of as little as 1% results in substantial (1) shortening of the saturation length, (2) increases in the efficiency, and (3) improvement in longitudinal coherence.
Synovial fluid nutrient delivery in the diathrial joint: An analysis of rabbit knee ligaments (1986)

The role of synovial fluid in providing nutrition to rabbit knee ligaments and menisci was evaluated by intraarticular injection of a labeled collagen precursor, tritiated proline. Incorporation of this substrate as tritiated hydroxyproline was measured in collateral and cruciate ligaments and menisci. The injectate volume (0.35 ml) did not appreciably change the overall joint pressure as measured by a wick catheter; therefore, no alteration of synovial membrane diffusion characteristics resulted. The concentration of the injected proline (0.52 mg%) was well below that normally present in serum (2.65 mg%). Therefore, incorporation of this substrate was not driven by a concentration gradient and represented normal uptake of synovial fluid and physiological incorporation of label as measured by the presence of tritiated hydroxyproline. Autoradiography was performed on all ligaments and menisci, and demonstrated concentration of the isotope and its metabolite (tritiated proline and tritiated hydroxyproline, respectively) in and around fibroblasts. This study indicates that rabbit knee ligaments and menisci can derive nutrition from a synovial fluid source.
Genome Characterization of the Oleaginous Fungus Mortierella alpina (2011)

Mortierella alpina is an oleaginous fungus which can produce lipids accounting for up to 50% of its dry weight in the form of triacylglycerols. It is used commercially for the production of arachidonic acid. Using a combination of high throughput sequencing and lipid profiling, we have assembled the M. alpina genome, mapped its lipogenesis pathway and determined its major lipid species. The 38.38 Mb M. alpina genome shows a high degree of gene duplications. Approximately 50% of its 12,796 gene models, and 60% of genes in the predicted lipogenesis pathway, belong to multigene families. Notably, M. alpina has 18 lipase genes, of which 11 contain the class 2 lipase domain and may share a similar function. M. alpina's fatty acid synthase is a single polypeptide containing all of the catalytic domains required for fatty acid synthesis from acetyl-CoA and malonyl-CoA, whereas in many fungi this enzyme is comprised of two polypeptides. Major lipids were profiled to confirm the products predicted in the lipogenesis pathway. M. alpina produces a complex mixture of glycerolipids, glycerophospholipids and sphingolipids. In contrast, only two major sterol lipids, desmosterol and 24(28)-methylene-cholesterol, were detected. Phylogenetic analysis based on genes involved in lipid metabolism suggests that oleaginous fungi may have acquired their lipogenic capacity during evolution after the divergence of Ascomycota, Basidiomycota, Chytridiomycota and Mucoromycota. Our study provides the first draft genome and comprehensive lipid profile for M. alpina, and lays the foundation for possible genetic engineering of M. alpina to produce higher levels and diverse contents of dietary lipids.
Choosing the objective of optimal routing protocols in Delay Tolerant networks (2010)

Networks in which nodes are sparsely distributed and, therefore, are disconnected for long periods of time, are termed Delay Tolerant networks (DTN). The intermittent connection, together, with the limited resources of mobile nodes, mainly power and memory, created a challenging environment for data networking in DTN. Routing protocols developed for DTN tend to discover and select the minimum end-to-end delay paths to destinations assuming that these paths provide the highest delivery rate. To achieve this goal, they spread many copies of the same packet, ignoring the limitedness of storage space and power sources. In this paper, we study this problem by building a mathematical model for optimal routing in DTN. We compare the results of implementing three objectives for this model: minimizing the end-to-end delay, minimizing the end-to-end number of hops, and maximizing the delivered messages. We study and analyze the impact of varying the buffer space, the traffic load and the packets time-to-live (TTL) on the three objectives. Results show that minimizing the number of hops provides higher delivery ratio than minimizing the delay, which contradicts the previous assumption. In addition, minimizing the number of hops significantly reduces the number of transmissions which results in saving energy.
Passive matrix Micro-LED display driven by STM32 microcontroller using a two-wire serial transmission method (2023)

Abstract In this study, the STM32 microcontroller is used to drive a passive matrix (PM) Micro-LED through two-wire serial transmission and row-column integration. STM32 exhibits superior properties, including simple-to-operate, cost-friendly, and flexible programming. Moreover, it has a lower cost and more straightforward implementation for testing the quality of the device and realizing the graphics. In this design, the connection between the STM32 and the PM array is realized by an LED driver board and flexible printed circuit (FPC) structure. The two-wire serial protocol and row-column integration are adopted, which not only optimizes the circuit structure but also avoids coupling problems. Compared to the existing structures, it is more concise that only four connecting wires are required to transmit data in display devices of any resolution. Besides, the problem of graphics distortion is solved through two buffers to form a data handshake. Using this method, the blue PM array, which has a resolution of 48 × 48, a refresh rate of 60 Hz, a pixel size of 300 μm, and a luminous area of 50 μm, is successfully realized. In addition, p-metal fractures caused by the bulge in the p-lines are also resolved by adding the GaN as a raised substrate.
High throughput modular chambers for rapid evaluation of anesthetic sensitivity (2006)

This system enabled assessment of inhaled anesthetic responsiveness with a higher precision than that previously reported. It is broadly adaptable for delivering an inhaled therapeutic (or toxin) to a population while monitoring its vital signs, motor reflexes, and providing precise control over environmental conditions. This system is also amenable to full automation. Data presented in this manuscript prove the utility of the controlled environment chambers and should allow for subsequent phenotyping of mice with targeted mutations that are expected to alter sensitivity to induction or emergence from anesthesia.
Tecnología de fabricación de arrabio con inyección de combustibles y otros materiales por toberas en el horno alto. II parte. Inyección de carbón pulverizado (ICP) (1998)

Se describe la tecnología de fabricación de arrabio con inyección de carbón por toberas en el horno alto. Se analiza y comenta la influencia de los principales constituyentes del carbón en la operación del horno. Se ofrece información sobre los países que emplean esta tecnología.
New Syntheses of Benzobarrelenes (1994)

New syntheses of both substituted and unsubstituted benzobarrelenes are described. Treatment of&#13;\n3,5-cyclohexadiene-cis-1,2-diol with benzaldehyde dimethylacetal in the presence of a catalytic amount of p-toluenesulfonic acid gave 1,2-(benzylidenedioxy)-3,5-cyclohexadiene(2). Addition of benzynes to 2 provided 3 and 4. Treatment of 3 and 4 with excess LDA and potassium tert-butoxide afforded benzobarrelenes 1 and 5 in good yields.
Improvement of road extraction in high resolution SAR data by a context-based approach (2005)

This paper deals with the problem of road extraction in high resolution SAR data. The presented method is an improvement of previous works. The process is an almost automatic algorithm based on a Hough transform and a road tracking algorithm. The main limitations of the process are due to the road context. First investigations to exploit contextual information in the process are presented.
Mise en evidence de l'expression d'une galectine de type 8 dans des cellules de cancer bronchique humain via le clonage de son adn complementaire (1997)

Un anticorps monoclonal po66 a ete obtenu apres immunisation de souris balb/c par des cellules provenant d'un carcinome epidermoide bronchique humain. En immunohistochimie, po66 se fixe sur tous les carcinomes epidermoides bronchiques testes et 50% des adenocarcinomes. Dans le present travail, nous avons etudie, par microscopie electronique, la localisation cellulaire de l'antigene sur un modele de spheroides multicellulaires. Nous avons observe que, si dans un premier temps, po66 se fixait sur des debris cellulaires, apres 72 heures d'incubation des spheroides en presence de l'anticorps, ce dernier etait localise dans des structures vacuolaires a l'interieur de cellules morphologiquement intactes. Nos observations suggerent que l'internalisation se produit par un mecanisme de phagocytose, les vesicules formees semblant penetrer progressivement dans les cellules vivantes. Par une etude biochimique, nous avons caracterise trois proteines de 47, 50 et 69 kda immunoprecipitees par po66, supposant l'existence probable de plusieurs antigenes. Par le criblage d'une banque adnc de cancer bronchique, nous avons isole differents clones codant pour une proteine appartenant aux galectines et plus particulierement a celle de type 8. Celle-ci a ete nommee po66-cbp, pour po66-carbohydrate binding protein. Plusieurs membres de cette famille ont ete a ce jour decrits dans divers types de cancers, notamment la galectine-8 dans les carcinomes de la prostate. L'analyse des differents clones, a montre l'existence de plusieurs arnm et d'au moins trois cadres de lecture potentiels dus a la presence de sequences insertionnelles dans certains clones isoles. L'etude de l'expression de po66-cbp dans differents tissus et cellules, sains et tumoraux, a permis de constater des expressions variables des differents transcrits possibles selon le type cellulaire etudie. Plusieurs galectines ont deja ete decrites dans differentes etudes de recherche contre le cancer. Po66-cbp pourrait faire partie de ces molecules impliquees dans certains processus lies a la progression tumorale.
COMP-15. META-ANALYSIS OF CANCER CELL LINES BASED ON THEIR RESPONSE TO TUMOR TREATING FIELDS (TTFIELDS) (2018)

Tumor Treating Fields (TTFields) therapy (low intensity, intermediate frequency (100–300 kHz alternating electric fields) is an approved modality for the treatment of glioblastoma. TTFields were shown to exert an inhibitory effect on numerous cancer cell lines with some variability in the response of different cell lines. The goal of the present study is to compare characteristics of cell lines based on their response pattern to TTFields. Forty different human cancerous cell lines were treated for 72 hours with TTFields at optimal cell-specific frequency at the same nominal intensity (1.7 V/cm). Cell survival and clonogenicity were determined. Functional analysis of differentially expressed genes and mutations associated with response to TTFields was performed based on the Cancer Cell Line Encyclopedia (CCLE) database. Sensitivity to TTFields was compared with pharmacological profiling (CCLE). TTFields application demonstrated varying degree of cytotoxic effect in all cell lines tested. The inhibitory response to TTFields was found to be distributed around an average of 50% with a cytotoxic effects ranging between 14% and 86% reductions in cell counts, and a clonogenic effect ranging between no effect and 88% reduction in the number of colonies. Pharmacological profiling based on IC50 values, revealed increased sensitivity to: Lapatinib, PHA-665752 and PLX-4720 within the group of cell lines which were less sensitive to TTFields. Functional analysis of cell line gene expression and mutation data revealed enriched pathways related to DNA damage repair response, cell migration, hypoxia signaling and oxidative stress. This meta-analysis of cancerous cell line response to TTFields demonstrates the broad effectiveness of TTFields in various cell lines and define the optimal frequency to be applied for each. The data presented in this work suggest that beside their anti-mitotic properties, TTFields may have effects on other cellular pathways. Pharmacological profiling may offer a rational for combining specific agents with TTFields.
Hip Range of Motion and Association With Injury in Female Professional Tennis Players (2014)

We report an association in female professional tennis players between abdominal strains and flexion contractures of the hip with iliopsoas tightness. We did not find evidence of specific hip adaptations in rotational range of motion. If hip flexion contractures are found on clinical examination, a stretching program may be indicated. Further studies are required to assess whether such a program can reduce the risk of abdominal injury.
IDAMC: A NoC for mixed criticality systems (2013)

Increasing demand for performance and further integration promotes the use of multi- and many-core systems - also in safety-critical embedded systems. In this domain, hardware platforms obviously have to support real-time, predictability constrained applications such as an anti-lock braking system. However, the on-going trend to integrate multiple functions with different criticalities (mixed critical) on a single platform calls for a paradigm shift. Mixed-critical systems require special attention with respect to functional (access protection) and non-functional (performance) isolation. An additional layer of protection and guaranteed service on the underlying infrastructure enables the efficient adoption of such architectures in safety-critical domains. In this paper, we present the IDAMC, a many-core platform which provides mechanisms to integrate applications of different criticalities on a single platform.
IMaxer (2017)

Due to the popularity of social networks with geo-tagged activities, so-called location-based social networks (LBSN), a number of methods have been proposed for influence maximization for applications such as word-of-mouth marketing (WOMM), and out-of-home marketing (OOH). It is thus important to analyze and compare these different approaches. In this demonstration, we present a unified system IMaxer that both provides a complete pipeline of state-of-the-art and novel models and algorithms for influence maximization (IM) as well as allows to evaluate and compare IM techniques for a particular scenario. IMaxer allows to select and transform the required data from raw LBSN datasets. It further provides a unified model that utilizes interactions of nodes in an LBSN, i.e., users and locations, for capturing diverse types of information propagations. On the basis of these interactions, influential nodes can be found and their potential influence can be simulated and visualized using Google Maps and graph visualization APIs. Thus, IMaxer allows users to compare and pick the most suitable IM method in terms of effectiveness and cost.
Preoperative CT and Intra-Operative Physical Space Registration of the Spine Using an Articulated Model: a Phantom Study (2014)

Purpose: Due to the difference in spine curvature in intra-operative and preoperative situations in image guided spine surgery (IGSS), each vertebra needs to be registered separately. This can be done by collecting anatomical landmarks on the patient’s anatomy using a pointer and a tracker, and registering them with corresponding points on the 3D model of CT images. Registering each vertebra using this method can be a tedious and time consuming task. Registering the spine using an articulated model, which incorporates the inter-vertebral transformation between consecutive vertebra, introduces a simple and efficient framework. Methods: In this paper, a deformation (extension) is applied to the lumbar vertebra of a spine phantom. Local coordinate systems are defined separately for each vertebra in the 3D model reconstructed from CT images before deformation and on the phantom after deformation. The intervertebral transformations for consecutive vertebrae are calculated in the 3D models. Registration is carried out using the local coordinate systems and the intervertebral transformations. Results: This method was evaluated using point based registration with known corresponding points in both spaces. These results were also compared to those of surface based registration. As indicated by the results, an average improvement of 30% in the registration accuracy was achieved compared to the surface based registration method with acquired random points. Conclusion: The proposed method decreases the registration time by eliminating the need to acquire surface points on each individual vertebra. It is also applicable in situations with defected vertebrae where anatomical landmarks are difficult to distinguish.
6.4.4 - Zustandsüberwachung von Motoren mit „smarten Sensor-Tags“ (2016)

eine groflchige Anwendung von beispielsweise
Existence of strong solutions for Itô's stochastic equations via approximations. Revisited (2021)

Given strong uniqueness for an Itô's stochastic equation, we prove that its solution can beconstructed on "any" probability space by using, for example, Euler's polygonal approximations. Stochastic equations in $\mathbb{R}^{d}$ and in domains in $\mathbb{R}^{d}$ are considered. This is almost a copy of an old article in which we correct errors in the original proof of Lemma 4.1 found by Martin Dieckmann in 2013. We present also a new result on the convergence of "tamed Euler approximations" for SDEs with locally unbounded drifts, which we achieve by proving an estimate for appropriate exponential moments.